title: Clinical significance of a blood eosinophilia in adult T-cell leukemia/lymphoma: a blood eosinophilia is a significant unfavorable prognostic factor.
abstract: We investigated the clinical significance of a blood eosinophilia in a cohort of 158 consecutive patients with adult T-cell leukemia/lymphoma (ATLL), and multivariate analysis revealed that a blood eosinophilia was an independent and a significant unfavorable prognostic factor. Interestingly, a blood eosinophilia was independent of serum LDH level, which might reflect the tumor burden. The present study shows that measurement of the blood eosinophil count is useful for predicting the prognosis and for determining a suitable treatment strategy for ATLL patients.
authors.affiliation: Department of Hematology, Imamura Bun-in Hospital, 11-23 Kamoikeshin-machi, Kagoshima-shi, Kagoshima 890-0064, Japan.
authors.forename: Atae
authors.initials: A
authors.lastname: Utsunomiya
authors.forename: Takashi
authors.initials: T
authors.lastname: Ishida
authors.forename: Atsushi
authors.initials: A
authors.lastname: Inagaki
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Ishii
authors.forename: Hiroki
authors.initials: H
authors.lastname: Yano
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Komatsu
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Iida
authors.forename: Kentaro
authors.initials: K
authors.lastname: Yonekura
authors.forename: Shogo
authors.initials: S
authors.lastname: Takeuchi
authors.forename: Yoshifusa
authors.initials: Y
authors.lastname: Takatsuka
authors.forename: Ryuzo
authors.initials: R
authors.lastname: Ueda
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D015331:Cohort Studies; D004802:Eosinophilia / Q000175:diagnosis*; D004804:Eosinophils / Q000473:pathology; D005260:Female; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000097:blood; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000175:diagnosis*; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D007770:L-Lactate Dehydrogenase