title: TSLP: an epithelial cell cytokine that regulates T cell differentiation by conditioning dendritic cell maturation.
abstract: Dendritic cells (DCs) are professional antigen-presenting cells that have the ability to sense infection and tissue stress, sample and present antigen to T lymphocytes, and induce different forms of immunity and tolerance. The functional versatility of DCs depends on their remarkable ability to translate collectively the information from both the invading microbes and their resident tissue microenvironments and then make an appropriate immune response. Recent progress in understanding TLR biology has illuminated the mechanisms by which DCs link innate and adaptive antimicrobial immune responses. However, how tissue microenvironments shape the function of DCs has remained elusive. Recent studies of TSLP (thymic stromal lymphopoietin), an epithelial cell-derived cytokine that strongly activates DCs, provide evidence at a molecular level that epithelial cells/tissue microenvironments directly communicate with DCs. We review recent progress on how TSLP expressed within thymus and peripheral lymphoid and nonlymphoid tissues regulates DC-mediated central tolerance, peripheral T cell homeostasis, and inflammatory Th2 responses.
authors.affiliation: Department of Immunology, Center of Cancer Immunology Research, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA. yjliu@mdanderson.org
authors.forename: Yong-Jun
authors.initials: YJ
authors.lastname: Liu
authors.forename: Vasilli
authors.initials: V
authors.lastname: Soumelis
authors.forename: Norihiko
authors.initials: N
authors.lastname: Watanabe
authors.forename: Tomoki
authors.initials: T
authors.lastname: Ito
authors.forename: Yui-Hsi
authors.initials: YH
authors.lastname: Wang
authors.forename: Rene de Waal
authors.initials: Rde W
authors.lastname: Malefyt
authors.forename: Miyuki
authors.initials: M
authors.lastname: Omori
authors.forename: Baohua
authors.initials: B
authors.lastname: Zhou
authors.forename: Steven F
authors.initials: SF
authors.lastname: Ziegler
mesh_terms: D000818:Animals; D017951:Antigen Presentation / Q000276:immunology*; D002454:Cell Differentiation / Q000276:immunology*; D016207:Cytokines / Q000276:immunology*; D003713:Dendritic Cells / Q000276:immunology*; D004847:Epithelial Cells / Q000276:immunology*; D006706:Homeostasis / Q000276:immunology; D006801:Humans; D007108:Immune Tolerance; D007113:Immunity, Innate; D007239:Infections / Q000276:immunology; D007249:Inflammation / Q000276:immunology; D008221:Lymphoid Tissue / Q000276:immunology; D018418:Th2 Cells / Q000276:immunology*; D051193:Toll-Like Receptors / Q000276:immunology; D000094632:Thymic Stromal Lymphopoietin
chemical_list: D016207:Cytokines; D051193:Toll-Like Receptors; D000094632:Thymic Stromal Lymphopoietin