"Click to chelate": synthesis and installation of metal chelates into biomolecules in a single step.
Click chemistry has been employed for the assembly of novel and efficient triazole-based multidentate chelating systems while simultaneously attaching them to molecules of biological interest. The "click-to-chelate" approach offers a powerful new tool for the modification of (bio)molecules with metal chelators for potential diagnostic and therapeutic applications.
Mindt
Thomas L
TL
Department of Chemistry and Applied Biosciences, ETH Zurich, 8093 Zurich, Switzerland.
Struthers
Harriet
H
Brans
Luc
L
Anguelov
Todor
T
Schweinsberg
Christian
C
Maes
Veronique
V
Tourwé
Dirk
D
Schibli
Roger
R
D000409:Alanine / Q000031:analogs & derivatives; D000480:Alkynes / Q000737:chemistry; D001386:Azides / Q000737:chemistry; D002614:Chelating Agents / Q000737:chemistry*; D007553:Isotope Labeling / Q000379:methods*; D008670:Metals / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry; D014230:Triazoles / Q000138:chemical synthesis / Q000737:chemistry*
D000480:Alkynes; D001386:Azides; D002614:Chelating Agents; D008670:Metals; D010455:Peptides; D014230:Triazoles; D000409:Alanine