Antioxidant activity of Pepticare, a herbomineral formulation, in experimentally induced renal and cardiac damage.
Pepticare, a herbomineral formulation, was administered orally to rats at the dose levels of 125, 250, 500 and 1000 mg/kg to investigate its effect on isoproterenol-induced myocardial infarction and cisplatin-induced renal damage. The drug reduced the levels of serum creatine kinase (CK), glutamic oxaloacetate transaminase (GOT), lactate dehydrogenase (LDH) and uric acid in isoproterenol-induced cardiac damage. In cisplatin-induced renal damage, Pepticare reduced the serum levels of creatinine, urea, blood urea nitrogen (BUN) and uric acid. It was further found that administration of Pepticare increased the levels of superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH), membrane bound enzymes like Ca2+ ATPase, Mg2+ ATPase and Na+ K+ ATPase and decreased lipid peroxidation (MDA) in heart and kidney, respectively. Thus it can be concluded that Pepticare possesses antioxidant activity and protects the heart and kidney from damage caused by isoproterenol and cisplatin, respectively.
Bafna
Pallavi Anand
PA
Indukaka Ipcowala College of Pharmacy, New Vallabh Vidyanagar, PO Vitthal Udyognagar, District Anand, Guja, India. pallavi2475@rediffmail.com
Balaraman
R
R
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002374:Catalase / Q000378:metabolism; D002945:Cisplatin; D052279:Creatine Kinase, MB Form / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D005978:Glutathione / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D007545:Isoproterenol; D015227:Lipid Peroxidation; D009203:Myocardial Infarction / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D008517:Phytotherapy / Q000379:methods*; D010946:Plants, Medicinal; D020011:Protective Agents / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D051437:Renal Insufficiency / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism; D013482:Superoxide Dismutase / Q000378:metabolism; D005723:gamma-Glutamyltransferase / Q000378:metabolism
D000975:Antioxidants; D020011:Protective Agents; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005723:gamma-Glutamyltransferase; D052279:Creatine Kinase, MB Form; D005978:Glutathione; D007545:Isoproterenol; D002945:Cisplatin