title: Future of antibody purification.
abstract: Antibody purification seems to be safely ensconced in a platform, now well-established by way of multiple commercialized antibody processes. However, natural evolution compels us to peer into the future. This is driven not only by a large, projected increase in the number of antibody therapies, but also by dramatic improvements in upstream productivity, and process economics. Although disruptive technologies have yet escaped downstream processes, evolution of the so-called platform is already evident in antibody processes in late-stage development. Here we perform a wide survey of technologies that are competing to be part of that platform, and provide our [inherently dangerous] assessment of those that have the most promise.
authors.affiliation: Amgen, Thousand Oaks, CA, USA.
authors.forename: Duncan
authors.initials: D
authors.lastname: Low
authors.forename: Rhona
authors.initials: R
authors.lastname: O'Leary
authors.forename: Narahari S
authors.initials: NS
authors.lastname: Pujar
mesh_terms: D000906:Antibodies / Q000737:chemistry / Q000302:isolation & purification*; D002498:Centrifugation / Q000379:methods / Q000639:trends; D002846:Chromatography, Affinity / Q000379:methods / Q000639:trends; D005544:Forecasting; D008024:Ligands; D015202:Protein Engineering / Q000379:methods* / Q000639:trends
chemical_list: D000906:Antibodies; D008024:Ligands