title: Periodontal disease and perinatal outcomes: a case-control study.
abstract: OBJECTIVE
  Our aim was to measure the association of maternal periodontitis with low birth weight (LBW), pre-term LBW, and intra-uterine growth restriction.
  
  
  METHODS
  An inclusive case-control design including subjects examined for periodontitis through attachment loss, information on perinatal outcomes and general health. Data were analysed through conditional logistic regression.
  
  
  RESULTS
  Cases (n=304) and controls (n=611) had similar prevalence and severity of periodontitis, defined as at least three sites, in different teeth, with loss of three or more millimetres of clinical attachment level. Several factors were associated with the outcome, but the crude odds ratio for periodontitis was not significant. Odds ratio were 0.93 [95% confidence interval (CI): 0.63-1.41] for LBW and 0.92 (95% CI:0.54-1.57) for pre-term LBW in the presence of periodontitis, after adjustment for maternal age, previous pregnancies, pre-natal care, smoking, previous low birth or premature birth and other medical conditions, on a hierarchical model.
  
  
  CONCLUSIONS
  Results do not support the hypothesis of association observed in previous studies after appropriate controlling for confounding variables. Negative peri-natal outcomes are better explained by determinants other than periodontal health. This study adds to the growing body of literature on the relationship between periodontal diseases and systemic health.
authors.affiliation: Centro de Pesquisas Epidemiológicas, Universidade Federal de Pelotas, Pelotas, Brazil. diego.bassani@gmail.com
authors.forename: D G
authors.initials: DG
authors.lastname: Bassani
authors.forename: M T A
authors.initials: MT
authors.lastname: Olinto
authors.forename: N
authors.initials: N
authors.lastname: Kreiger
mesh_terms: D001724:Birth Weight; D016022:Case-Control Studies; D004522:Educational Status; D005260:Female; D005317:Fetal Growth Retardation / Q000209:etiology; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007234:Infant, Premature; D008423:Maternal Age; D010298:Parity; D017622:Periodontal Attachment Loss / Q000150:complications; D010518:Periodontitis / Q000150:complications*; D011247:Pregnancy; D011248:Pregnancy Complications; D011256:Pregnancy Outcome; D047928:Premature Birth; D011295:Prenatal Care; D012907:Smoking; D012923:Social Class