Proposal of a new and simple staging system of colorectal liver metastasis.
OBJECTIVE
To create a new, simple and useful staging system for colorectal liver metastasis analogous to the Tumor Node Metastasis classification system of International Union Against Cancer.


METHODS
A retrospective review was undertaken of 81 consecutive patients who underwent partial hepatectomy for colorectal liver metastases (group 1). Clinical and pathological features of both primary and metastatic liver cancers were entered into a multivariate analysis to determine independent variables helpful in accurately predicting long-term prognosis after hepatectomy. Using selected variables, we created a new staging system like TNM classification. The usefulness of the new staging system was examined in a series of 92 patients from another hospital (group 2).


RESULTS
Multivariate analysis showed that 81 patients in group 1 had significant multiple hepatic tumors with the largest tumor being more than 5 cm in diameter, resectable extrahepatic distant metastases, and independent prognostic factors for poor survival after hepatectomy. Using these three variables, we created a new staging system to classify patients with colorectal liver metastases. Finally, our new staging system classified the patients both in group 1 and in group 2.


CONCLUSIONS
Our new staging system of colorectal liver metastasis is simple and useful for staging patients.
Nagashima
Ikuo
I
Department of Surgery, Teikyo University, School of Medicine, Tokyo 173-8605, Japan. inaga@med.teikyo-u.ac.jp
Takada
Tadahiro
T
Nagawa
Hirokazu
H
Muto
Tetsuichiro
T
Okinaga
Kota
K
D000328:Adult; D015179:Colorectal Neoplasms / Q000473:pathology*; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000145:classification* / Q000175:diagnosis / Q000401:mortality / Q000556:secondary*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009362:Neoplasm Metastasis / Q000175:diagnosis / Q000473:pathology; D009367:Neoplasm Staging / Q000145:classification / Q000379:methods* / Q000639:trends*; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate