title: [Fulminant liver failure associated with T-cell non-Hodgkin's lymphoma and hepatitis C virus: a case report].
abstract: Hematological malignancies can affect the liver, without producing severe hepatic involvement. We report the case of a 57-year-old man with hepatitis C virus infection and mild chronic hepatitis without antiviral treatment, who developed an aggressive T-cell non-Hodgkin's lymphoma confirmed by histological studies including liver, lymph nodes and bone marrow. The patient developed massive hepatic infiltration and acute liver failure. Rescue chemotherapy was administered but the patient died soon after with severe lactic acidosis. The immunopathological features of this association and the few reports of cases presenting with acute liver failure are reviewed.
authors.affiliation: Sección de Gastroenterología. Hospital Clínico Universidad de Chile. Santiago de Chile. Chile.
authors.forename: Pamela
authors.initials: P
authors.lastname: Cofré
authors.forename: José Miguel
authors.initials: JM
authors.lastname: Valera
authors.forename: Gladys
authors.initials: G
authors.lastname: Smok
authors.forename: Carlos
authors.initials: C
authors.lastname: Regonessi
authors.forename: Javier
authors.initials: J
authors.lastname: Brahm
mesh_terms: D017809:Fatal Outcome; D006526:Hepatitis C / Q000150:complications* / Q000473:pathology; D006801:Humans; D017114:Liver Failure, Acute / Q000209:etiology* / Q000473:pathology; D016399:Lymphoma, T-Cell / Q000150:complications* / Q000473:pathology; D008297:Male; D008875:Middle Aged