title: The biological significance of mtNOS modulation.
abstract: In the last years, nitric oxide synthases (NOS) have been localized in mitochondria. At this site, NO yield directly regulates the activity of cytochrome oxidase, O(2) uptake and the production of reactive oxygen species. Recent studies showed that translocated neuronal nitric oxide synthase (nNOS) is posttranslationally modified including phosphorylation at Ser 1412 (in mice) and myristoylation in an internal residue. Different studies confirm that modified nNOS alpha is the main modulable isoform in mitochondria. Modulation of mtNOS was observed in different situations, like adaptation to reduced O(2) availability and hypoxia, adaptation to low environmental temperature, and processes linked to life and death by effects on kinases and transcription factors. We present here evidence about the role of mtNOS in the analyzed conditions.
authors.affiliation: Laboratory of Oxygen Metabolism, University Hospital, University of Buenos Aires, Buenos Aires, Argentina. ccarreras@hospitaldeclinicas.uba.ar
authors.forename: María C
authors.initials: MC
authors.lastname: Carreras
authors.forename: María C
authors.initials: MC
authors.lastname: Franco
authors.forename: Paola V
authors.initials: PV
authors.lastname: Finocchietto
authors.forename: Daniela P
authors.initials: DP
authors.lastname: Converso
authors.forename: Valeria G
authors.initials: VG
authors.lastname: Antico Arciuch
authors.forename: Silvia
authors.initials: S
authors.lastname: Holod
authors.forename: Jorge G
authors.initials: JG
authors.lastname: Peralta
authors.forename: Juan J
authors.initials: JJ
authors.lastname: Poderoso
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D001921:Brain / Q000196:embryology / Q000201:enzymology / Q000254:growth & development; D008099:Liver / Q000196:embryology / Q000201:enzymology / Q000254:growth & development; D051379:Mice; D008928:Mitochondria / Q000201:enzymology*; D009473:Neuronal Plasticity; D052248:Nitric Oxide Synthase Type I / Q000502:physiology*; D010100:Oxygen / Q000378:metabolism; D014284:Triiodothyronine / Q000502:physiology
chemical_list: D014284:Triiodothyronine; D052248:Nitric Oxide Synthase Type I; D010100:Oxygen