title: Inositol phosphates and phosphoinositides in health and disease.
abstract: In the past two decades, considerable progress has been made toward understanding inositol phosphates and PI metabolism. However, there is still much to learn. The present challenge is to understand how inositol phosphates and PIs are compartmentalized, identify new targets of inositol phosphates and PIs, and elucidate the mechanisms underlying spatial and temporal regulation of the enzymes that metabolize inositol phosphates and PIs. Answers to these questions will help clarify the mechanisms of the diseases associated with these molecules and identify new possibilities for drug design.
authors.affiliation: Department of Biological Sciences, Wayne State University, Detroit, MI 48202, USA.
authors.forename: Yihui
authors.initials: Y
authors.lastname: Shi
authors.forename: Abed N
authors.initials: AN
authors.lastname: Azab
authors.forename: Morgan N
authors.initials: MN
authors.lastname: Thompson
authors.forename: Miriam L
authors.initials: ML
authors.lastname: Greenberg
mesh_terms: D000818:Animals; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology*; D006801:Humans; D007295:Inositol Phosphates / Q000502:physiology*; D009369:Neoplasms / Q000503:physiopathology*; D009422:Nervous System Diseases / Q000503:physiopathology*; D010716:Phosphatidylinositols / Q000502:physiology*
chemical_list: D007295:Inositol Phosphates; D010716:Phosphatidylinositols