title: Analgesic activity of Calotropis gigantea flower.
abstract: The alcoholic extract of the flowers of Calotropis gigantea was administered orally and explored for its analgesic activity in chemical and thermal models in mice. In acetic acid induced writhing test, an inhibition of 20.97% and 43.0% in the number of writhes was observed at the doses of 250 and 500 mg/kg, respectively. In the hot plate method the paw licking time was delayed. The analgesic effect was observed after 30 min of dose administration which reached its maximum after 90 min.
authors.affiliation: Department of Pharmacy, Barkatullah University, Bhopal, MP 462026, India. anupampathak@yahoo.com
authors.forename: A K
authors.initials: AK
authors.lastname: Pathak
authors.forename: A
authors.initials: A
authors.lastname: Argal
mesh_terms: D019342:Acetic Acid; D000284:Administration, Oral; D000700:Analgesics / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D031107:Calotropis; D004305:Dose-Response Relationship, Drug; D005260:Female; D035264:Flowers; D006358:Hot Temperature; D008297:Male; D051379:Mice; D010146:Pain / Q000139:chemically induced / Q000517:prevention & control*; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D000700:Analgesics; D010936:Plant Extracts; D019342:Acetic Acid