Glycine conjugated and free bile acids, aided by acid suppression, can easily enter the esophageal epithelium where they can activate oncogenes and eventually carcinogenesis.
Stamp
Dennis
D
D001471:Barrett Esophagus / Q000235:genetics / Q000378:metabolism; D001647:Bile Acids and Salts / Q000737:chemistry / Q000378:metabolism / Q000633:toxicity*; D002471:Cell Transformation, Neoplastic / Q000187:drug effects*; D004847:Epithelial Cells / Q000378:metabolism*; D004938:Esophageal Neoplasms / Q000139:chemically induced / Q000453:epidemiology / Q000209:etiology*; D004947:Esophagus / Q000166:cytology*; D005998:Glycine / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D015994:Incidence; D008954:Models, Biological; D009857:Oncogenes / Q000235:genetics*; D012995:Solubility
D001647:Bile Acids and Salts; D005998:Glycine