Effects of composition, solvent, and salt particles on the physicochemical properties of polyglycolide/poly(lactide-co-glycolide) scaffolds.
Polyglycolide (PGA)/poly(lactide-co-glycolide) (PLGA) scaffolds were fabricated by a solvent casting/particulate leaching method using hexafluoroisopropanol (HFIP) or acetone for material dissolution and NaCl particles as porogen. The results revealed that the mechanical strength increased as the PGA percentage in a HFIP-processed scaffold increased. Chemical ingredients did not substantially affect the mechanical strength of acetone-processed scaffolds. Large NaCl particles led to weak mechanical strength, low porosity, and small specific surface area. For a fixed composition, PGA crystals in a HFIP-processed scaffold were smaller than those in an acetone-processed scaffold. High PGA fractions yielded partly fused PGA/PLGA scaffolds. A faster degradation rate of a scaffold could result from a higher PGA percentage, smaller NaCl particles, or the existence of chondrocytes. The combination of PGA and PLGA, which compensated each other for bioactivity, would be beneficial to cartilage regeneration.
Kuo
Yung-Chih
YC
Department of Chemical Engineering, National Chung Cheng University, Chia-Yi, Taiwan 62102, Republic of China. chmyck@ccu.edu.tw
Leou
Sho-Noen
SN
D001672:Biocompatible Materials / Q000737:chemistry; D040761:Biomimetic Materials / Q000737:chemistry*; D018929:Cell Culture Techniques / Q000295:instrumentation / Q000379:methods*; D003470:Culture Media / Q000737:chemistry*; D004548:Elasticity; D005109:Extracellular Matrix / Q000737:chemistry*; D006244:Hardness; D019344:Lactic Acid / Q000737:chemistry*; D008422:Materials Testing; D011100:Polyglycolic Acid / Q000737:chemistry*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011108:Polymers / Q000737:chemistry*; D012492:Salts / Q000737:chemistry*; D012997:Solvents / Q000737:chemistry*; D013718:Tensile Strength; D023822:Tissue Engineering / Q000295:instrumentation / Q000379:methods*
D001672:Biocompatible Materials; D003470:Culture Media; D011108:Polymers; D012492:Salts; D012997:Solvents; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid