[Paracoccidioidomycosis in cerebral hemisphere and brainstem: case report].
We report on a 36 years-old man that had been at the Amazon forest four years before. Six months before the admission he had developed a progressive quadriparesis, gait ataxia, dysphagia, dysarthria, difficulty in breathing and hiccup. The gadolinium-enhanced T1-weighted MRI showed a lesion into the right parietoccipital area and another into the medulla, that was the largest. There was any evidence of tuberculosis or AIDS. The patient was submitted to microsurgical approach to the medulla. Pathological examination revealed paracoccidioidomycosis. Treatment with anphotericin B till 2100 mg was administered followed by sulfamethoxazole-trimetoprim for three months plus physical therapy. The patient went back to his activities six months after the end of the treatment. Comments are presented about the participation of the immunological system and of the cytokines (interleukines).
Leal Filho
Manoel Baldoino
MB
Universidade Estadual de Campinas SP, Brazil. manoelbaldoino@uol.com.br
Borges
Guilherme
G
da Silva
Raimundo Gerônimo
RG
de Almeida Xavier Aguiar
Aline
A
de Almeida
Bruno Ribeiro
BR
da Cunha E Silva Vieira
Marcelo Adriano
MA
Pinheiro
Luciana Maria Ribeiro
LM
D000328:Adult; D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D001927:Brain Diseases / Q000175:diagnosis / Q000382:microbiology* / Q000628:therapy; D003131:Combined Modality Therapy / Q000379:methods; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D010229:Paracoccidioidomycosis / Q000175:diagnosis* / Q000628:therapy; D016896:Treatment Outcome; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000627:therapeutic use
D000935:Antifungal Agents; D000666:Amphotericin B; D015662:Trimethoprim, Sulfamethoxazole Drug Combination