title: Evolution of pyrrolidine-type asymmetric organocatalysts by "click" chemistry.
abstract: Click chemistry has been employed to construct a library of the pyrrolidine-type asymmetric organocatalysts. The clicked organocatalysts were evaluated in asymmetric Michael addition of ketones to nitroolefins, showing good catalytic activity and stereoselectivity (up to 100% yield, syn:anti = 99:1, 96% ee).
authors.affiliation: Beijing National Laboratory for Molecular Sciences, Center for Chemical Biology, Institute of Chemistry, Chinese Academy of Science, Beijing, 100080 China. luosz@iccas.ac.cn
authors.forename: Sanzhong
authors.initials: S
authors.lastname: Luo
authors.forename: Hui
authors.initials: H
authors.lastname: Xu
authors.forename: Xueling
authors.initials: X
authors.lastname: Mi
authors.forename: Jiuyuan
authors.initials: J
authors.lastname: Li
authors.forename: Xiaoxi
authors.initials: X
authors.lastname: Zheng
authors.forename: Jin-Pei
authors.initials: JP
authors.lastname: Cheng
mesh_terms: D002384:Catalysis; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D009930:Organic Chemicals / Q000737:chemistry*; D011759:Pyrrolidines / Q000737:chemistry*
chemical_list: D009930:Organic Chemicals; D011759:Pyrrolidines; C032519:pyrrolidine