title: Increased prolactin in acute coronary syndromes as putative Co-activator of ADP-stimulated P-selectin expression.
abstract: Prolactin and leptin are newly recognized platelet co-stimulators due to enhancement of ADP-induced platelet aggregation. The aim of our study was to assess whether both hormones prolactin and leptin play a role as co-activators of platelet activation in patients with acute coronary syndromes. Twenty-one patients with acute coronary syndromes, 10 with stable angina pectoris and 10 controls were studied. Patients with acute coronary syndromes showed significantly higher prolactin and leptin values and a significant increased P-selectin expression on platelets compared to patients with stable angina pectoris or controls. However, patients with acute myocardial infarction as a subgroup of acute coronary syndromes showed the highest prolactin levels as well as ADP stimulated P-selectin expression. In the myocardial infarction subgroup prolactin values showed a significant correlation to ADP stimulated P-selectin expression on platelets (r (2)=0.41; p=0.025), whereas leptin was not correlated. Our data indicate an association between increased prolactin values and enhanced P-selectin expression on platelets in patients with acute coronary syndromes. Therefore, the stress hormone prolactin could be a co-stimulator of platelet activation in these patients. In contrast, the putative platelet activator leptin does not seem to play a major role in acute coronary syndromes.
authors.affiliation: Medical Clinic 2, University Hospital Erlangen, Germany. dorette.raaz@med2.imed.uni-erlangen.de
authors.forename: D
authors.initials: D
authors.lastname: Raaz
authors.forename: H
authors.initials: H
authors.lastname: Wallaschofski
authors.forename: C
authors.initials: C
authors.lastname: Stumpf
authors.forename: A
authors.initials: A
authors.lastname: Yilmaz
authors.forename: I
authors.initials: I
authors.lastname: Cicha
authors.forename: L
authors.initials: L
authors.lastname: Klinghammer
authors.forename: W G
authors.initials: WG
authors.lastname: Daniel
authors.forename: T
authors.initials: T
authors.lastname: Lohmann
authors.forename: C D
authors.initials: CD
authors.lastname: Garlichs
mesh_terms: D000244:Adenosine Diphosphate / Q000502:physiology*; D000368:Aged; D000789:Angina, Unstable / Q000097:blood; D001792:Blood Platelets / Q000378:metabolism; D003327:Coronary Disease / Q000378:metabolism*; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D020738:Leptin / Q000097:blood; D008297:Male; D009203:Myocardial Infarction / Q000097:blood; D019007:P-Selectin / Q000097:blood*; D011388:Prolactin / Q000097:blood*
chemical_list: D020738:Leptin; D019007:P-Selectin; D000244:Adenosine Diphosphate; D011388:Prolactin