title: Synthesis and biological evaluation of azido- and aziridino-hydroxyl-beta-lactams through stereo- and regioselective epoxide ring opening.
abstract: Two new classes of azido- and aziridino-hydroxyl-beta-lactam containing structures have been prepared by means of a stereo- and regioselective epoxide ring opening. The straightforwardness of the procedure makes this strategy useful for the synthesis of potentially bioactive compounds. Some selected examples showed promising activity in acyl CoA-cholesterol acyltransferase inhibition assays.
authors.affiliation: Department of Chemistry "G. Ciamician", University of Bologna, Via Selmi 2, 40126 Bologna, Italy.
authors.forename: Fides
authors.initials: F
authors.lastname: Benfatti
authors.forename: Giuliana
authors.initials: G
authors.lastname: Cardillo
authors.forename: Luca
authors.initials: L
authors.lastname: Gentilucci
authors.forename: Rossana
authors.initials: R
authors.lastname: Perciaccante
authors.forename: Alessandra
authors.initials: A
authors.lastname: Tolomelli
authors.forename: Alberico
authors.initials: A
authors.lastname: Catapano
mesh_terms: D001386:Azides / Q000737:chemistry*; D001388:Aziridines / Q000737:chemistry*; D004852:Epoxy Compounds / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D047090:beta-Lactams / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D001386:Azides; D001388:Aziridines; D004852:Epoxy Compounds; D047090:beta-Lactams