title: [Advances in radio-oncology. From precision radiotherapy with photons to ion therapy with protons and carbon ions].
abstract: Modern techniques in radiation oncology, such as fractionated stereotactic radiotherapy (FSRT), stereotactic radiosurgery (SRS) or intensity modulated radiotherapy (IMRT) allow the application of high local doses to defined treatment volumes, while normal structures in close vicinity can be spared; high local control rates can be achieved, while treatment-related toxicity can be minimized. Innovative Hi-Art tomotherapy systems offer an alternative, combining a 6 MV photon accelerator with a CT scanner. Ion beams, such as protons and carbon ions, have been shown to be beneficial for distinct tumor entities. Both offer a characteristic physical dose distribution with an inverse dose profile contributing to beneficial dose conformality. Carbon ions also offer the advantage of increased relative biological effectiveness. For certain tumor types, a significant increase in local control and survival rates could be obtained with carbon ions.
authors.affiliation: Klinik für Radioonkologie und Strahlentherapie, Universitätsklinikum Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Deutschland. Stephanie.Combs@med.uni-heidelberg.de
authors.forename: S E
authors.initials: SE
authors.lastname: Combs
authors.forename: D
authors.initials: D
authors.lastname: Schulz-Ertner
authors.forename: K K
authors.initials: KK
authors.lastname: Herfarth
authors.forename: R
authors.initials: R
authors.lastname: Krempien
authors.forename: J
authors.initials: J
authors.lastname: Debus
mesh_terms: D002244:Carbon / Q000627:therapeutic use; D006801:Humans; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional; D007477:Ions; D008279:Magnetic Resonance Imaging; D009369:Neoplasms / Q000000981:diagnostic imaging / Q000601:surgery*; D017785:Photons / Q000627:therapeutic use; D061766:Proton Therapy; D016634:Radiosurgery / Q000379:methods*; D025321:Surgery, Computer-Assisted / Q000379:methods*; D014057:Tomography, X-Ray Computed
chemical_list: D007477:Ions; D002244:Carbon