Bayesian dynamic models for survival data with a cure fraction.
In this paper, we propose a new class of semi-parametric cure rate models. Specifically, we construct dynamic models for piecewise hazard functions over a finite partition of the time axis. Allowing the size of partition and the levels of baseline hazard to be random, our proposed models provide a great flexibility in controlling the degree of parametricity in the right tail of the survival distribution and the amount of correlations among the log-baseline hazard levels. Several properties of the proposed models are derived, and propriety of the implied posteriors with improper noninformative priors for regression coefficients based on the proposed models is established for the fixed partition of the time axis. In addition, an efficient reversible jump computational algorithm is developed for carrying out posterior computation. A real data set from a melanoma clinical trial is analyzed in detail to further demonstrate the proposed methodology.
Kim
Sungduk
S
Department of Statistics, University of Connecticut, Storrs, CT 06269, USA. sdkim@stat.uconn.edu
Chen
Ming-Hui
MH
Dey
Dipak K
DK
Gamerman
Dani
D
D001499:Bayes Theorem; D001699:Biometry / Q000379:methods; D002986:Clinical Trials as Topic; D006801:Humans; D008545:Melanoma / Q000453:epidemiology / Q000401:mortality; D016016:Proportional Hazards Models; D012074:Remission Induction; D016019:Survival Analysis; D016896:Treatment Outcome