Efficacy of DNA immunization with F and G protein genes of Nipah virus.
We investigated the antibody response of DNA immunization with two mammalian codon optimized envelope glycoprotein genes, F and G, of Nipah virus in a mouse model. The results indicated that G gene immunization elicited more significant specific serum IgG response and neutralization antibody response than F gene did, suggesting that the G gene DNA immunization is a potential vaccine strategy against Nipah virus.
Wang
Xijun
X
National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Science, Harbin 150001, P.R. China.
Ge
Jinying
J
Hu
Sen
S
Wang
Qinghua
Q
Wen
Zhiyun
Z
Chen
Hualan
H
Bu
Zhigao
Z
D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis; D045464:Henipavirus Infections / Q000517:prevention & control / Q000635:transmission / Q000662:veterinary*; D006801:Humans; D007114:Immunization / Q000662:veterinary; D007074:Immunoglobulin G / Q000096:biosynthesis; D051379:Mice; D045405:Nipah Virus / Q000276:immunology*; D019444:Vaccines, DNA / Q000276:immunology*; D014759:Viral Envelope Proteins / Q000276:immunology; D014760:Viral Fusion Proteins / Q000276:immunology; D014764:Viral Proteins / Q000276:immunology*; D014765:Viral Vaccines / Q000276:immunology*
D000914:Antibodies, Viral; D007074:Immunoglobulin G; D019444:Vaccines, DNA; D014759:Viral Envelope Proteins; D014760:Viral Fusion Proteins; D014764:Viral Proteins; D014765:Viral Vaccines; C116204:attachment protein G