[Determination of haloperidol in fingernail/toenails by LC-ESI-Ms].
The report presents the possibility of using fingernails/ toenails to determine haloperidol levels. The described determinations were performed using the method of liquid chromatography coupled with electrospray-ionization mass spectrophotometry (LC-ESI-MS). In the course of the investigation, the authors developed a method for isolating haloperidol from nails and its identification. Determinations were performed in fingernail/toenail samples originating from individuals who had been administered haloperidol at least 6 months prior to sample collection. The materials demonstrated the presence of haloperidol in the following amount: fingernails - 67.3 +/- 6.49 pg/mg, toenails- 98.9 +/- 9.14 pg/mg.
Pufal
Ewa
E
Katedry i Zakładu Medycyny Sadowej CM UMK w Bydgoszczy.
Piotrowski
Przemysław
P
D014150:Antipsychotic Agents / Q000302:isolation & purification*; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D005260:Female; D006220:Haloperidol / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D009262:Nails / Q000737:chemistry*; D015203:Reproducibility of Results
D014150:Antipsychotic Agents; D006220:Haloperidol