title: Protection of gruntlings against classical swine fever virus-infection after oral vaccination of sows with C-strain vaccine.
abstract: The objective of this study was to investigate the maternal protection of gruntlings derived from wild sows vaccinated orally against classical swine fever (CSF) using C-strain vaccine. Three vaccinated sows and one unvaccinated control sow were included. Challenge infection of the progeny was carried out either intranasally or by contact at the beginning of the third month of life (61-65 days post-natum). Whereas, two of three litters had maternal antibodies, the progeny of one vaccinated sow was seronegative at challenge. The progeny of the control sow, which was challenged by contact infection, developed moderate clinical signs except for one animal which became ill and died. Two gruntlings derived from the vaccinated sows also died of CSF, although one of them had a relatively high maternal antibody titre (128 ND(50)). The transient infection and partial virus shedding observed in a small number of gruntlings with maternal antibodies and the fact that one animal with maternal antibodies became ill and died confirm the incomplete maternal protection at this age. The reason for this incomplete protection is discussed. As none of the surviving gruntlings could be shown to carry CSFV or viral RNA at the end of the experiment (36 or 70 d.p.i.), it may be concluded that these animals do not represent a potential CSFV reservoir.
authors.affiliation: Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Institute of Infectology, Boddenblick 5a, 17493 Greifswald-Insel Riems, Germany. volker.kaden@fli.bund.de
authors.forename: V
authors.initials: V
authors.lastname: Kaden
authors.forename: E
authors.initials: E
authors.lastname: Lange
authors.forename: T
authors.initials: T
authors.lastname: Müller
authors.forename: J
authors.initials: J
authors.lastname: Teuffert
authors.forename: J P
authors.initials: JP
authors.lastname: Teifke
authors.forename: R
authors.initials: R
authors.lastname: Riebe
mesh_terms: D000818:Animals; D000831:Animals, Newborn / Q000097:blood; D000914:Antibodies, Viral / Q000097:blood*; D006691:Classical Swine Fever / Q000097:blood / Q000635:transmission*; D006692:Classical Swine Fever Virus / Q000276:immunology*; D005260:Female; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control / Q000662:veterinary; D011247:Pregnancy; D011897:Random Allocation; D013552:Swine; D014611:Vaccination / Q000662:veterinary*; D014765:Viral Vaccines / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral; D014765:Viral Vaccines