A simple asymmetric organocatalytic approach to optically active cyclohexenones.
Optically active 2,5-disubstituted-cyclohexen-2-one derivatives have been prepared in a one-pot process consisting of five reaction steps: an organocatalytic asymmetric conjugated addition of beta-ketoesters to alpha,beta-unsaturated aldehydes that proceeds in aqueous solutions or under solvent-free conditions has been implemented in a multi-step process.
Carlone
Armando
A
Danish National Research Foundation: Center for Catalysis, Department of Chemistry, Aarhus University, DK 8000, Aarhus C, Denmark.
Marigo
Mauro
M
North
Chris
C
Landa
Aitor
A
Jørgensen
Karl Anker
KA
D000447:Aldehydes / Q000737:chemistry*; D002384:Catalysis; D003512:Cyclohexanones / Q000138:chemical synthesis* / Q000737:chemistry; D004952:Esters / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D015394:Molecular Structure; D009904:Optical Rotation; D013237:Stereoisomerism; D014867:Water / Q000737:chemistry
D000447:Aldehydes; D003512:Cyclohexanones; D004952:Esters; D007659:Ketones; D014867:Water