Crystallographic protein model-building on the web.
X-ray crystallography is the most widely used method to determine the 3D structure of protein molecules. One of the most difficult steps in protein crystallography is model-building, which consists of constructing a backbone and then amino acid side chains into an electron density map. Interpretation of electron density maps represents a major bottleneck in protein structure determination pipelines, and thus, automated techniques to interpret maps can greatly improve the throughput. We have developed WebTex, a simple and yet powerful web interface to TEXTAL, a program that automates this process of fitting atoms into electron density maps. TEXTAL can also be downloaded for local installation.


BACKGROUND
Web interface, downloadable binaries and documentation at http://textal.tamu.edu
Gopal
Kreshna
K
Department of Computer Science, Texas A&M University, 301 H.R. Bright Building, College Station, TX 77843-3112, USA. textal@tamu.edu
McKee
Erik
E
Romo
Tod
T
Pai
Reetal
R
Smith
Jacob
J
Sacchettini
James
J
Ioerger
Thomas
T
D000465:Algorithms; D003198:Computer Simulation; D003461:Crystallography / Q000379:methods*; D020407:Internet; D008956:Models, Chemical; D008958:Models, Molecular; D011487:Protein Conformation; D011506:Proteins / Q000737:chemistry* / Q000648:ultrastructure*; D020539:Sequence Analysis, Protein / Q000379:methods; D012984:Software
D011506:Proteins