title: Re-evaluating cell-cycle regulation by E2Fs.
abstract: Activation of E2F transcription factors is thought to drive the expression of genes essential for the transition of cells from G1 to S phase and for the initiation of DNA replication. However, this textbook view of E2Fs is increasingly under challenge. Here we discuss an alternative model for how E2Fs may work.
authors.affiliation: Division of Molecular Carcinogenesis and Center of Biomedical Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.
authors.forename: Benjamin D
authors.initials: BD
authors.lastname: Rowland
authors.forename: René
authors.initials: R
authors.lastname: Bernards
mesh_terms: D000818:Animals; D002453:Cell Cycle; D050684:E2F Transcription Factors / Q000737:chemistry / Q000378:metabolism*; D008957:Models, Genetic; D017434:Protein Structure, Tertiary; D012097:Repressor Proteins / Q000378:metabolism; D015533:Transcriptional Activation
chemical_list: D050684:E2F Transcription Factors; D012097:Repressor Proteins