Glucose-transport regulation in leukemic cells: how can H2O2 mimic stem cell factor effects?
In leukemic cells, glucose transport is activated by SCF and H2O2 through a common signal cascade involving Akt, PLCgamma, Syk, and the Src family, in this order. An explanation can be provided by the phosphorylation of c-kit, the SCF receptor, elicited by either SCF or H2O2. Moreover, antioxidants prevent the SCF effect on glucose transport, confirming the involvement of H2O2 in the pathway leading to glucose-transport activation and suggesting a potential role for reactive oxygen species in leukemia proliferation.
Maraldi
Tullia
T
Department of Biochemistry "G. Moruzzi," University of Bologna, Italy. tullia.maraldi@unibo.it
Fiorentini
Diana
D
Prata
Cecilia
C
Landi
Laura
L
Hakim
Gabriele
G
D000620:Aminoimidazole Carboxamide / Q000031:analogs & derivatives / Q000378:metabolism; D000975:Antioxidants / Q000378:metabolism; D001692:Biological Transport; D049109:Cell Proliferation; D016207:Cytokines / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000494:pharmacology; D015973:Gene Expression Regulation, Leukemic; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D006861:Hydrogen Peroxide / Q000494:pharmacology*; D007938:Leukemia / Q000378:metabolism*; D010766:Phosphorylation; D012265:Ribonucleotides / Q000378:metabolism; D015398:Signal Transduction; D019089:Stem Cell Factor / Q000378:metabolism*; D014443:Tyrosine / Q000737:chemistry
D000975:Antioxidants; D016207:Cytokines; D004791:Enzyme Inhibitors; D012265:Ribonucleotides; D019089:Stem Cell Factor; D000620:Aminoimidazole Carboxamide; D014443:Tyrosine; D006861:Hydrogen Peroxide; C031143:AICA ribonucleotide; D005947:Glucose