Oncogenic inflammation and autoimmune disease.
Many models exist to explain the induction and perpetuation of autoimmune diseases. Despite their validation in a variety of animal models, the basis for autoimmune disease in humans remains unknown. Here, we propose that an important aspect of autoimmune disease is the active participation of the target organ due to endogenously produced co-stimulatory factors that cause prolonged antigen presentation and lymphocyte activation. Evidence suggests that a major source of such endogenous signaling comes from newly transformed cells within the target organ that produce pro-inflammatory factors.
Eisenlohr
Laurence C
LC
Departments of Microbiology/Immunology and Otolaryngology-HNS, Kimmel Cancer Center, Thomas Jefferson University, 233 South 10th Street, Philadelphia, PA 19107, USA.
Rothstein
Jay L
JL
D000818:Animals; D017951:Antigen Presentation / Q000276:immunology; D001327:Autoimmune Diseases / Q000209:etiology*; D002471:Cell Transformation, Neoplastic / Q000276:immunology*; D006801:Humans; D007249:Inflammation / Q000150:complications*; D008213:Lymphocyte Activation / Q000276:immunology; D018448:Models, Immunological; D009369:Neoplasms / Q000276:immunology*