title: Experimental approaches to assess metallotoxicity and ageing in models of Alzheimer's disease.
abstract: This review highlights advantages and disadvantages of experimental procedures (chemical, cellular, physiological, histochemical and epidemiological) that have been used to identify Alzheimer- and dementia-related targets for exogenous toxins, and discusses how neuronal function can be assessed experimentally, based on the evidence obtained for the neurotoxin aluminium.
authors.affiliation: School of Medical Sciences, University of Aberdeen, Scotland, UK. b.platt@abdn.ac.uk
authors.forename: Bettina
authors.initials: B
authors.lastname: Platt
mesh_terms: D000375:Aging / Q000502:physiology*; D000535:Aluminum / Q000378:metabolism* / Q000633:toxicity*; D000544:Alzheimer Disease / Q000378:metabolism* / Q000473:pathology*; D000818:Animals; D002118:Calcium / Q000378:metabolism; D016923:Cell Death / Q000502:physiology; D003072:Cognition Disorders / Q000175:diagnosis; D004781:Environmental Exposure / Q000009:adverse effects; D006624:Hippocampus / Q000378:metabolism* / Q000473:pathology*; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D007150:Immunohistochemistry; D015398:Signal Transduction / Q000502:physiology; D014867:Water / Q000378:metabolism
chemical_list: D014867:Water; D000535:Aluminum; D002118:Calcium