title: Chlorination byproducts, their toxicodynamics and removal from drinking water.
abstract: No doubt that chlorination has been successfully used for the control of water borne infections diseases for more than a century. However identification of chlorination byproducts (CBPs) and incidences of potential health hazards created a major issue on the balancing of the toxicodynamics of the chemical species and risk from pathogenic microbes in the supply of drinking water. There have been epidemiological evidences of close relationship between its exposure and adverse outcomes particularly the cancers of vital organs in human beings. Halogenated trihalomethanes (THMs) and haloacetic acids (HAAs) are two major classes of disinfection byproducts (DBPs) commonly found in waters disinfected with chlorine. The total concentration of trihalomethanes and the formation of individual THM species in chlorinated water strongly depend on the composition of the raw water, on operational parameters and on the occurrence of residual chlorine in the distribution system. Attempts have been made to develop predictive models to establish the production and kinetics of THM formations. These models may be useful for operational purposes during water treatment and water quality management. It is also suggested to explore some biomarkers for determination of DBP production. Various methods have been suggested which include adsorption on activated carbons, coagulation with polymer, alum, lime or iron, sulfates, ion exchange and membrane process for the removal of DBPs. Thus in order to reduce the public health risk from these toxic compounds regulation must be inforced for the implementation of guideline values to lower the allowable concentrations or exposure.
authors.affiliation: Aquatic Toxicology Division, Industrial Toxicology Research Centre, Post Box-80, M.G. Marg, Lucknow-226001, India. krishnagopaldubey@gmail.com
authors.forename: Krishna
authors.initials: K
authors.lastname: Gopal
authors.forename: Sushree Swarupa
authors.initials: SS
authors.lastname: Tripathy
authors.forename: Jean Luc
authors.initials: JL
authors.lastname: Bersillon
authors.forename: Shashi Prabha
authors.initials: SP
authors.lastname: Dubey
mesh_terms: D000085:Acetates / Q000009:adverse effects / Q000302:isolation & purification / Q000493:pharmacokinetics; D002713:Chlorine / Q000009:adverse effects* / Q000493:pharmacokinetics; D004203:Disinfection; D006801:Humans; D018570:Risk Assessment; D022882:Trihalomethanes / Q000009:adverse effects / Q000302:isolation & purification / Q000493:pharmacokinetics; D014874:Water Pollutants, Chemical / Q000302:isolation & purification* / Q000493:pharmacokinetics; D014881:Water Supply / Q000592:standards*
chemical_list: D000085:Acetates; D022882:Trihalomethanes; D014874:Water Pollutants, Chemical; D002713:Chlorine