Analysis of the hierarchy of quorum-sensing regulation in Pseudomonas aeruginosa.
Quorum-sensing in Pseudomonas aeruginosa is known to regulate several aspects of pathogenesis, including virulence factor production, biofilm development, and antimicrobial resistance. Recent high-throughput analysis has revealed the existence of several layers of regulation within the QS-circuit. To address this complexity, mutations in genes encoding known or putative transcriptional regulators that were also identified as being regulated by the las and/or rhl QS systems were screened for their contribution in mediating several phenotypes, for example motility, secreted virulence products, and pathogenic capacity in a lettuce leaf model. These studies have further elucidated the potential contribution to virulence of these genes within the QS regulon.
Wagner
Victoria E
VE
Department of Microbiology and Immunology, School of Medicine and Dentistry, University of Rochester, Box 672, Rochester, NY 14642, USA.
Li
Luen-Luen
LL
Isabella
Vincent M
VM
Iglewski
Barbara H
BH
D018407:Bacterial Physiological Phenomena; D015964:Gene Expression Regulation, Bacterial / Q000235:genetics; D009154:Mutation; D020411:Oligonucleotide Array Sequence Analysis; D011550:Pseudomonas aeruginosa / Q000235:genetics* / Q000472:pathogenicity* / Q000502:physiology; D053038:Quorum Sensing; D014157:Transcription Factors / Q000235:genetics; D014158:Transcription, Genetic; D014774:Virulence / Q000235:genetics
D014157:Transcription Factors