Association of SUMO4, as a candidate gene for IDDM5, with susceptibility to type 1 diabetes in Asian populations.
Recent study demonstrated that M55V variant in SUMO4 at IDDM5 was associated with susceptibility to type 1 diabetes. Subsequent studies, however, showed inconsistency in the association. To clarify the population-wide effect on the association of SUMO4 with type 1 diabetes, we have performed meta-analysis including our own data in Asian populations, which confirmed a highly significant association in Asian populations (summary odds ratio [OR]: 1.29, P = 7.0 x 10(-6)), but indicated significant heterogeneity in the genetic effect of the SUMO4 gene on type 1 diabetes among diverse ethnic groups. These observations indicated the association of SUMO4 with type 1 diabetes in Asian populations.
Noso
Shinsuke
S
Department of Endocrinology, Diabetes and Metabolism, Kinki University School of Medicine, 377-2 Ohno-higashi, Sayama-shi, Osaka 589-8511, Japan.
Ikegami
Hiroshi
H
Fujisawa
Tomomi
T
Kawabata
Yumiko
Y
Asano
Katsuaki
K
Hiromine
Yoshihisa
Y
Sugihara
Shigetaka
S
Lee
Inkyu
I
Kawasaki
Eiji
E
Awata
Takuya
T
Ogihara
Toshio
T
D000483:Alleles; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D002896:Chromosomes, Human, Pair 6; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics*; D005787:Gene Frequency; D018740:Genetic Heterogeneity; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D006801:Humans; D007564:Japan / Q000453:epidemiology; D011110:Polymorphism, Genetic; D025841:Small Ubiquitin-Related Modifier Proteins / Q000235:genetics*; D044465:White People / Q000235:genetics
C489647:SUMO4 protein, human; D025841:Small Ubiquitin-Related Modifier Proteins