Immunological aspects of circulating DNA.
Nude mice were injected with DNA released by T lymphocytes previously exposed to inactivated herpes symplex type 1 or polio viruses. The serum of these mice was tested for its neutralizing activity. Injected nude mice synthesized antiherpetic or antipolio antibodies, depending on the antigen used to sensitize the T lymphocytes. Mice injected with DNA released by human T cells produced antibodies carrying human allotypes as they could be neutralized by antiallotype sera. However, mice that were injected with DNA released by antigen-stimulated murine T lymphocytes produced antiviral antibodies, which were not neutralized by anti-human allotype sera.
Anker
Philippe
P
OncoXL, 14 chemin de Aulx, 1228 Plan les Ouates/Geneva, Switzerland. panker@worldcom.ch
Stroun
Maurice
M
D000818:Animals; D000906:Antibodies / Q000276:immunology; D002478:Cells, Cultured; D004247:DNA / Q000097:blood / Q000276:immunology; D006801:Humans; D016131:Lymphocyte Subsets / Q000166:cytology / Q000276:immunology; D051379:Mice; D008819:Mice, Nude; D017955:Poliovirus / Q000276:immunology; D018139:Simplexvirus / Q000276:immunology; D013601:T-Lymphocytes / Q000166:cytology / Q000502:physiology*
D000906:Antibodies; D004247:DNA