[Content of myosin-activating protein kinases in myocardium of patients with dilated cardiomyopathy and in the animal heart].
The skeletal myosin light chain kinase (skMLCK) was identified in human and chicken embryo myocardium but not in embryo and adult rat heart using western blotting. The content of skMLCK and myosin-activating protein kinases: RhaA-activated protein kinase (ROCK), integrin-linked protein kinase (ILK), and zipper-interacting protein kinase (ZIPK) was compared in normal human myocardium and the hearts of patients with dilated cardiomyopathy (DCM). It was demonstrated that the content of skMLCK, ROCK and ILK increases in DCM whereas the content of ZIPK decreases. The results obtained may reflect compensatory processes in cardiomyocytes in DMC, which are aimed at increasing their viability and contractility.
Chadin
A V
AV
Belokurova
M V
MV
Stepanova
O V
OV
Ivanova
M V
MV
Shirinskiĭ
V P
VP
D000367:Age Factors; D000818:Animals; D002311:Cardiomyopathy, Dilated / Q000201:enzymology*; D002642:Chick Embryo; D006321:Heart / Q000196:embryology; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000378:metabolism; D018482:Muscle, Skeletal / Q000201:enzymology; D009206:Myocardium / Q000201:enzymology*; D009219:Myosin-Light-Chain Kinase / Q000378:metabolism; D009218:Myosins / Q000378:metabolism*; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D051381:Rats; D013045:Species Specificity; D054460:rho-Associated Kinases; D000099200:Scaffold Protein ILK
D047908:Intracellular Signaling Peptides and Proteins; D009219:Myosin-Light-Chain Kinase; D009218:Myosins; D017346:Protein Serine-Threonine Kinases; D054460:rho-Associated Kinases; D000099200:Scaffold Protein ILK