Preparation of prolonged release clarithromycin microparticles for oral use and their in vitro evaluation.
Prolonged release microparticles of clarithromycin (CL) were prepared using Eudragit RL 100 and RS 100 by spray-drying and casting-drying techniques. For the characterization of those microparticles, preparation yield, particle size distribution, X-ray diffraction, thermal behavior, active agent content and in vitro dissolution from the microparticles were performed. HPLC was used for the assay of clarithromycin and the assay method was validated. All the formulations obtained showed prolonged release when compared to pure clarithromycin. Microparticles prepared by spray-drying method had a slower release compared to those of casting-drying method. Spray-drying method seems to be a more suitable method to prepare microparticles for prolongation in release.
Genç
Lüffi
L
Department of Pharmaceutical Technology, Anadolu University, Faculty of Pharmacy, 26470, Eskisehir Turkiye. lgenc@anadolu.edu.tr
Demirel
Müzeyyen
M
Yazan
Yasemin
Y
D000180:Acrylic Resins / Q000032:analysis / Q000493:pharmacokinetics; D000284:Administration, Oral; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics; D001682:Biological Availability; D002626:Chemistry, Pharmaceutical / Q000379:methods; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D017291:Clarithromycin / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D003460:Crystallization; D003692:Delayed-Action Preparations / Q000008:administration & dosage / Q000138:chemical synthesis / Q000493:pharmacokinetics*; D004355:Drug Stability; D005079:Excipients; D005612:Freeze Drying / Q000191:economics / Q000379:methods; D010316:Particle Size; D015203:Reproducibility of Results; D012995:Solubility; D013055:Spectrophotometry, Infrared / Q000379:methods; D013678:Technology, Pharmaceutical / Q000379:methods*; D013997:Time Factors; D014961:X-Ray Diffraction / Q000379:methods
D000180:Acrylic Resins; D000900:Anti-Bacterial Agents; D003692:Delayed-Action Preparations; D005079:Excipients; C050528:Eudragit RS; D017291:Clarithromycin