4-Hydroxyproline metabolism and glyoxylate production: A target for substrate depletion in primary hyperoxaluria?
The primary hyperoxalurias are diseases of overproduction of oxalate. The immediate precursor of oxalate is glyoxylate. Metabolism of hydroxyproline, derived from collagen turnover or the diet, appears to be a major source of glyoxylate, and a potential target for a therapeutic strategy of substrate depletion.
Coulter-Mackie
M B
MB
Department of Pediatrics, University of British Columbia, Vancouver, Canada. marioncm@interchange.ubc.ca
D000328:Adult; D005260:Female; D006038:Glyoxylates / Q000378:metabolism*; D006801:Humans; D006909:Hydroxyproline / Q000378:metabolism*; D006960:Hyperoxaluria, Primary / Q000378:metabolism / Q000628:therapy*; D008297:Male; D010070:Oxalates / Q000378:metabolism
D006038:Glyoxylates; D010070:Oxalates; C031150:glyoxylic acid; D006909:Hydroxyproline