title: Efficacy of a skin-protection powder for use as a dressing for intractable ulcers.
abstract: OBJECTIVE
  Stomahesive skin-protection powder has been reported to be useful as a skin-care and skin-barrier product for the management of stomas. This study aimed to evaluate its efficacy, in terms of wound healing, moisture retention and pain management, as an alternative to conventional dressing materials. Both clinical and animal studies were undertaken.
  
  
  METHODS
  The efficacy of the Stomahesive powder was tested by measuring the thickness of granulation tissue formed in a total skin defect in a db/db mouse model. We then compared the healing process using either the skin-protection powder or a conventional film dressing material. In the clinical study 17 patients with various intractable ulcers were treated with Stomahesive powder, and healing was evaluated.
  
  
  RESULTS
  In the mouse model, granulation tissue in the wounds treated with the powder was 2.86 times thicker than that of the wounds treated with the film dressing. In the clinical study, 16 out of 17 wounds healed completely.
  
  
  CONCLUSIONS
  The Stomahesive powder could be an effective treatment modality for contact ulceration, superficial ulcers with complex contours and morphology, and superficial ulcers contaminated by liquid faeces or vaginal discharge that have not responded to conventional dressings.
  
  
  BACKGROUND
  None.
authors.affiliation: Department of Plastic, Reconstructive and Aesthetic Surgery, Burn Care Unit, Kyorin University School of Medicine,Tokyo, Japan. nohura-tky@umin.ac.jp
authors.forename: N
authors.initials: N
authors.lastname: Ohura
authors.forename: T
authors.initials: T
authors.lastname: Kurita
authors.forename: A
authors.initials: A
authors.lastname: Takushima
authors.forename: M
authors.initials: M
authors.lastname: Shibata
authors.forename: K
authors.initials: K
authors.lastname: Harii
mesh_terms: D000279:Administration, Cutaneous; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D002266:Carboxymethylcellulose Sodium / Q000494:pharmacology / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004338:Drug Combinations; D004341:Drug Evaluation; D005260:Female; D005780:Gelatin / Q000494:pharmacology / Q000627:therapeutic use*; D006097:Granulation Tissue / Q000187:drug effects; D006801:Humans; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D008875:Middle Aged; D009779:Occlusive Dressings / Q000592:standards*; D010368:Pectins / Q000494:pharmacology / Q000627:therapeutic use*; D011090:Polyenes / Q000494:pharmacology / Q000627:therapeutic use*; D011208:Powders; D017592:Skin Care; D012883:Skin Ulcer / Q000209:etiology / Q000473:pathology / Q000628:therapy*; D018709:Statistics, Nonparametric; D014945:Wound Healing
chemical_list: D004338:Drug Combinations; D011090:Polyenes; D011208:Powders; C012044:stomadhesive; D010368:Pectins; D005780:Gelatin; D002266:Carboxymethylcellulose Sodium