title: Complete response of highly advanced colon cancer with multiple lymph node metastases to irinotecan combined with UFT: report of a case.
abstract: Massive lymph node metastasis of the para-aortic region and supraclavicular lymph nodes, Virchow's lymph node metastasis due to colon cancer, is extremely rare. We herein report a case of such systemic lymph node metastasis that was successfully treated with a combination of irinotecan (CPT-11) and UFT, a combination drug of tegafur and uracil. The patient was a 57-year-old woman who had a tumor in the ascending colon, and massively swollen para-aortic and supraclavicular lymph node metastasis. She was treated with combination chemotherapy of CPT-11 and UFT. The main tumor was detected as a decompressed scar, and the supraclavicular and para-aortic lymph nodes had completely disappeared after the second cycle of treatment. A histopathological examination and immunohistochemistry with cytokeratin showed complete remission of adenocarcinoma in the tumor and para-aortic lymph nodes. She remains alive without recurrence 52 months after chemotherapy. Combination chemotherapy of CPT-11 and UFT may be of potential value in the treatment of advanced colorectal carcinoma, and both histopathological and immunohistochemical confirmation of a complete remission may indicate prolonged disease-free survival.
authors.affiliation: Department of Surgery, Graduate School of Medicine, Osaka University, Suita 565-0871, Japan.
authors.forename: Yujiro
authors.initials: Y
authors.lastname: Fujie
authors.forename: Masataka
authors.initials: M
authors.lastname: Ikeda
authors.forename: Iwao
authors.initials: I
authors.lastname: Seshimo
authors.forename: Koji
authors.initials: K
authors.lastname: Ezumi
authors.forename: Taishi
authors.initials: T
authors.lastname: Hata
authors.forename: Tatsushi
authors.initials: T
authors.lastname: Shingai
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Yasui
authors.forename: Osamu
authors.initials: O
authors.lastname: Takayama
authors.forename: Hiroki
authors.initials: H
authors.lastname: Fukunaga
authors.forename: Masakazu
authors.initials: M
authors.lastname: Ikenaga
authors.forename: Ichiro
authors.initials: I
authors.lastname: Takemasa
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Yamamoto
authors.forename: Masayuki
authors.initials: M
authors.lastname: Ohue
authors.forename: Mitsugu
authors.initials: M
authors.lastname: Sekimoto
authors.forename: Seiichi
authors.initials: S
authors.lastname: Hirota
authors.forename: Morito
authors.initials: M
authors.lastname: Monden
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis / Q000188:drug therapy* / Q000556:secondary; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002166:Camptothecin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D003110:Colonic Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D003113:Colonoscopy; D004791:Enzyme Inhibitors / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D000077146:Irinotecan; D008207:Lymphatic Metastasis; D008875:Middle Aged; D011355:Prodrugs; D005641:Tegafur / Q000008:administration & dosage / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed; D014498:Uracil / Q000008:administration & dosage / Q000627:therapeutic use
chemical_list: D004791:Enzyme Inhibitors; D011355:Prodrugs; D005641:Tegafur; D014498:Uracil; D000077146:Irinotecan; D002166:Camptothecin