title: Basic ventilator management: lung protective strategies.
abstract: Acute respiratory failure is manifested clinically as a patient with variable degrees of respiratory distress, but characteristically an abnormal arterial blood partial pressure of oxygen or carbon dioxide. The application of mechanical ventilation in this setting can be life-saving. An emerging body of clinical and basic research, however, has highlighted the potential adverse effects of positive pressure ventilation. Clinicians involved with the care of critically ill patients must recognize and seek to prevent these complications using lung-protective ventilation strategies. This article discusses the basic concepts of mechanical ventilation, reviews the categories of ventilator-associated lung injury, and discusses current strategies for the recognition and prevention of these adverse effects in the application of mechanical ventilation.
authors.affiliation: Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh School of Medicine, 3459 Fifth Avenue, 628 NW, Pittsburgh, PA 15213, USA. donahoem@upmc.edu
authors.forename: Michael
authors.initials: M
authors.lastname: Donahoe
mesh_terms: D001469:Barotrauma / Q000503:physiopathology / Q000517:prevention & control; D006801:Humans; D008173:Lung Diseases, Obstructive / Q000628:therapy; D011175:Positive-Pressure Respiration; D011650:Pulmonary Alveoli / Q000502:physiology / Q000503:physiopathology; D012119:Respiration; D012121:Respiration, Artificial / Q000009:adverse effects / Q000379:methods; D012128:Respiratory Distress Syndrome / Q000503:physiopathology; D013314:Stress, Mechanical; D013990:Tidal Volume