Dioxygenase-catalysed dihydroxylation of arene cis-dihydrodiols and acetonide derivatives: a new approach to the synthesis of enantiopure tetraoxygenated bioproducts from arenes.
cis-Dihydrodiols of anthracene and benz[a]anthracene, and acetonide derivatives of the cis-dihydrodiols of benzene, fluorobenzene, biphenyl and phenanthrene have been identified as substrates for dioxygenase enzymes, yielding the corresponding enantiopure arene bioproducts, bis(cis-dihydrodiol)s and cis-diol acetonides respectively.
Boyd
Derek R
DR
School of Chemistry and Chemical Engineering, Belfast, UKBT9 5AG. dr.boyd@qub.ac.uk
Sharma
Narain D
ND
Belhocine
Tayeb
T
Malone
John F
JF
McGregor
Stuart
S
Allen
Christopher C R
CC
D001555:Benzene Derivatives / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D018360:Crystallography, X-Ray; D049308:Dioxygenases / Q000737:chemistry*; D006900:Hydroxylation; D008958:Models, Molecular; D008968:Molecular Conformation; D009284:Naphthols / Q000737:chemistry*; D011084:Polycyclic Aromatic Hydrocarbons / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
D001555:Benzene Derivatives; D009284:Naphthols; D011084:Polycyclic Aromatic Hydrocarbons; D049308:Dioxygenases