New-onset diabetes after kidney transplantation: risk factors.
New-onset diabetes after transplantation (NODAT) contributes to the risk for cardiovascular disease and infection, reducing graft and patient survival. For improvement of the outcome of kidney transplant recipients, it is of great interest to know precisely the risk factors that contribute to NODAT development. Nonmodifiable risk factors for development of NODAT are age, race, genetic background, family history of diabetes, and previous glucose intolerance. Modifiable risk factors are obesity and overweight, hepatitis C virus and cytomegalovirus infections, and immunosuppressive drugs. Both steroids and calcineurin inhibitors influence the appearance of NODAT, whereas the role of sirolimus in glucose metabolism currently is controversial.
Rodrigo
Emilio
E
Nephrology service, University of Cantabria, Avda. Valdecilla s/n 39008, Santander, Spain.
Fernández-Fresnedo
Gema
G
Valero
Rosalía
R
Ruiz
Juan Carlos
JC
Piñera
Celestino
C
Palomar
Rosa
R
González-Cotorruelo
Julio
J
Gómez-Alamillo
Carlos
C
Arias
Manuel
M
D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology* / Q000209:etiology / Q000235:genetics; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects; D016030:Kidney Transplantation / Q000009:adverse effects*; D009765:Obesity / Q000150:complications; D012307:Risk Factors; D014777:Virus Diseases / Q000150:complications
D007166:Immunosuppressive Agents