Evolution of pyrrolidine-type asymmetric organocatalysts by "click" chemistry.
Click chemistry has been employed to construct a library of the pyrrolidine-type asymmetric organocatalysts. The clicked organocatalysts were evaluated in asymmetric Michael addition of ketones to nitroolefins, showing good catalytic activity and stereoselectivity (up to 100% yield, syn:anti = 99:1, 96% ee).
Luo
Sanzhong
S
Beijing National Laboratory for Molecular Sciences, Center for Chemical Biology, Institute of Chemistry, Chinese Academy of Science, Beijing, 100080 China. luosz@iccas.ac.cn
Xu
Hui
H
Mi
Xueling
X
Li
Jiuyuan
J
Zheng
Xiaoxi
X
Cheng
Jin-Pei
JP
D002384:Catalysis; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D009930:Organic Chemicals / Q000737:chemistry*; D011759:Pyrrolidines / Q000737:chemistry*
D009930:Organic Chemicals; D011759:Pyrrolidines; C032519:pyrrolidine