Synthesis and DNA-binding ability of C2R-fluoro substituted DC-81 and its dimers.
C2R-Fluoro substituted DC-81 and its dimers have been synthesized that exhibit significant DNA-binding ability, particularly the five carbon alkane spacer compound (6c) showed the helix melting temperature (DeltaTm) of 18.8 degrees C after incubation of 36 h at 37 degrees C.
Kamal
Ahmed
A
Biotransformation Laboratory, Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500007, India. ahmedkamal@iict.res.in
Rajasekhar Reddy
D
D
Murali Mohan Reddy
P S
PS
D001569:Benzodiazepines / Q000138:chemical synthesis* / Q000494:pharmacology*; D004247:DNA / Q000378:metabolism*; D006358:Hot Temperature; D007202:Indicators and Reagents; D011489:Protein Denaturation; D011758:Pyrroles / Q000138:chemical synthesis* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D007202:Indicators and Reagents; D011758:Pyrroles; C438462:pyrrolo(2,1-c)(1,4)benzodiazepine; D001569:Benzodiazepines; D004247:DNA