title: Inversion (11)(p15q22) with NUP98-DDX10 fusion gene in pediatric acute myeloid leukemia.
abstract: The inv(11)(p15q22), a rare but recurrent chromosome abnormality that creates a NUP98-DDX10 fusion gene, is associated with de novo or secondary myeloid malignancies. We report a case of acute monocytic leukemia presenting this rearrangement, studied using fluorescence in situ hybridization (FISH) and reverse transcriptase-PCR (RT-PCR). We also review the cases of inv(11) associated with NUP98-DDX10 reported in the literature.
authors.affiliation: Dipartimento di Ematologia ed Oncologia Pediatrica, IRCCS Istituto Giannina Gaslini, Largo G Gaslini 5, Genoa, Italy.
authors.forename: Cristina
authors.initials: C
authors.lastname: Morerio
authors.forename: Maura
authors.initials: M
authors.lastname: Acquila
authors.forename: Annamaria
authors.initials: A
authors.lastname: Rapella
authors.forename: Elisa
authors.initials: E
authors.lastname: Tassano
authors.forename: Cristina
authors.initials: C
authors.lastname: Rosanda
authors.forename: Claudio
authors.initials: C
authors.lastname: Panarello
mesh_terms: D002648:Child; D007446:Chromosome Inversion; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics*; D053487:DEAD-box RNA Helicases / Q000235:genetics*; D050939:Gene Fusion; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy / Q000201:enzymology / Q000235:genetics*; D008297:Male; D008969:Molecular Sequence Data; D028861:Nuclear Pore Complex Proteins / Q000235:genetics*
chemical_list: D028861:Nuclear Pore Complex Proteins; C465451:Nup98 protein, human; C499217:DDX10 protein, human; D053487:DEAD-box RNA Helicases