title: Enantioselective synthesis and selective monofunctionalization of (4R,6R)-4,6- dihydroxy-2,8-dioxabicyclo[3.3.0]octane.
abstract: An efficient, enantioselective synthesis of a disubstituted bis-THF scaffold 5 is described, as well as an efficient differentiation of the 1,3-diol unit. [reaction: see text]
authors.affiliation: University of Southampton, School of Chemistry, Highfield, Southampton SO17 1BJ, U.K. bruno.linclau@soton.ac.uk
authors.forename: Bruno
authors.initials: B
authors.lastname: Linclau
authors.forename: Martin J
authors.initials: MJ
authors.lastname: Jeffery
authors.forename: Solen
authors.initials: S
authors.lastname: Josse
authors.forename: Cyrille
authors.initials: C
authors.lastname: Tomassi
mesh_terms: D019380:Anti-HIV Agents / Q000138:chemical synthesis / Q000737:chemistry; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000138:chemical synthesis*; D000069454:Darunavir; D005663:Furans / Q000737:chemistry; D007202:Indicators and Reagents; D007783:Lactones / Q000138:chemical synthesis*; D010084:Oxidation-Reduction; D013237:Stereoisomerism; D013449:Sulfonamides / Q000138:chemical synthesis / Q000737:chemistry
chemical_list: C522316:4,6-dihydroxy-2,8-dioxabicyclo(3.3.0)octane; D019380:Anti-HIV Agents; D019086:Bridged Bicyclo Compounds, Heterocyclic; D005663:Furans; D007202:Indicators and Reagents; D007783:Lactones; D013449:Sulfonamides; D000069454:Darunavir