Low-frequency subthalamic oscillations increase after deep brain stimulation in Parkinson's disease.
This work is the second of a series of papers in which we investigated the neurophysiological basis of deep brain stimulation (DBS) clinical efficacy using post-operative local field potential (LFP) recordings from DBS electrodes implanted in the subthalamic nucleus (STN) in patients with Parkinson's disease. We found that low-frequency (1-1.5Hz) oscillations in LFP recordings from the STN of patients with Parkinson's disease dramatically increase after DBS of the STN itself (log power change=0.93+/-0.62; Wilcoxon: p=0.0002, n=13), slowly decaying to baseline levels after turning DBS off. The DBS-induced increase of low-frequency LFP oscillations is highly reproducible and appears only after the delivery of DBS for a time long enough to induce clinical improvement. This increase of low-frequency LFP oscillations could reflect stimulation-induced modulation of network activity or could represent changes of the electrochemical properties at the brain-electrode interface.
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Dipartimento di Scienze Neurologiche, Università di Milano, Fondazione IRCCS Ospedale Policlinico, Milano, Italy. alberto.priori@unimi.it
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Foffani
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D000200:Action Potentials / Q000502:physiology; D000328:Adult; D000368:Aged; D016477:Artifacts; D001479:Basal Ganglia / Q000033:anatomy & histology / Q000503:physiopathology; D001683:Biological Clocks / Q000502:physiology*; D046690:Deep Brain Stimulation / Q000379:methods*; D004566:Electrodes / Q000592:standards; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009415:Nerve Net / Q000033:anatomy & histology / Q000503:physiopathology; D009434:Neural Pathways / Q000033:anatomy & histology / Q000503:physiopathology; D010300:Parkinson Disease / Q000503:physiopathology / Q000628:therapy*; D020531:Subthalamic Nucleus / Q000033:anatomy & histology / Q000502:physiology*; D016896:Treatment Outcome