title: A methodology for using SPECT to reduce intensity-modulated radiation therapy (IMRT) dose to functioning lung.
abstract: OBJECTIVE
  Single photon emission computed tomography (SPECT) provides a map of the spatial distribution of lung perfusion. Thus, SPECT guidance can be used to divert dose away from higher-functioning lung, potentially reducing lung toxicity. We present a methodology for achieving this aim and test it in intensity-modulated radiotherapy (IMRT) treatment-planning.
  
  
  METHODS
  IMRT treatment plans were generated with and without SPECT guidance and compared for 5 patients. Healthy lung was segmented into four regions on the basis of SPECT intensity in the SPECT plan. Dose was sequentially allowed to the target via regions of increasing SPECT intensity. This process results in reduction of dose to functional lung, reflected in the dose-function histogram (DFH). The plans were compared using DFHs and F(20)/F(30) values (F(x) is the functional lung receiving dose above x Gy).
  
  
  RESULTS
  In all cases, the SPECT-guided plan produced a more favorable DFH compared with the non-SPECT-guided plan. Additionally, the F(20) and F(30) values were reduced for all patients by an average of 13.6% +/- 5.2% and 10.5% +/- 5.8%, respectively. In all patients, DFHs of the two highest-functioning SPECT regions were reduced, whereas DFHs of the two lower-functioning regions were increased, illustrating the dose "give-take" between SPECT regions during redistribution.
  
  
  CONCLUSIONS
  SPECT-guided IMRT shows potential for reducing the dose delivered to highly functional lung regions. This dose reduction could reduce the number of high-grade pneumonitis cases that develop after radiation treatment and improve patient quality of life.
authors.affiliation: Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA. mcgui026@mc.duke.edu
authors.forename: Sarah M
authors.initials: SM
authors.lastname: McGuire
authors.forename: Sumin
authors.initials: S
authors.lastname: Zhou
authors.forename: Lawrence B
authors.initials: LB
authors.lastname: Marks
authors.forename: Mark
authors.initials: M
authors.lastname: Dewhirst
authors.forename: Fang-Fang
authors.initials: FF
authors.lastname: Yin
authors.forename: Shiva K
authors.initials: SK
authors.lastname: Das
mesh_terms: D000465:Algorithms; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging* / Q000502:physiology / Q000528:radiation effects; D008175:Lung Neoplasms / Q000000981:diagnostic imaging* / Q000532:radiotherapy*; D011832:Radiation Injuries / Q000517:prevention & control*; D011879:Radiotherapy Dosage; D050397:Radiotherapy, Intensity-Modulated / Q000379:methods*; D013679:Technology, Radiologic / Q000379:methods; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*