Increase in visfatin after weight loss induced by gastroplastic surgery.
OBJECTIVE
The recently described adipokine visfatin is produced in visceral fat and has been suggested to influence insulin resistance. To investigate whether visfatin concentrations are related to changes in body weight, this adipokine was measured in insulin-resistant severely obese patients before and after gastroplastic surgery.


METHODS
Visfatin, interleukin-6, high-sensitivity C-reactive protein, homeostasis model assessment of insulin resistance (HOMA-IR), and other clinical parameters were assessed in 36 severely obese subjects (28 female; mean age, 43 years) with a median BMI of 44.3 kg/m(2) (95% confidence interval, 43.3 to 48.1 kg/m(2)).


RESULTS
After surgery, BMI decreased to a median of 31.9 kg/m(2) (30.1 to 35.1 kg/m(2)) (p < 0.0001). Median visfatin concentrations increased significantly after weight loss [70.9 ng/mL (61.4 to 75.6 ng/mL) vs. 86.4 ng/mL (79.4 to 89.8 ng/mL); p < 0.0005]. This increase correlated with the decrease of insulin and HOMA-IR and was associated with a reduction in plasma interleukin-6 and high-sensitivity C-reactive protein concentrations.


CONCLUSIONS
Massive weight loss after gastroplastic surgery is accompanied by an increase in circulating concentrations of the novel adipokine visfatin. This increase correlates with the decrease in plasma insulin concentrations and HOMA-IR.
Krzyzanowska
Katarzyna
K
Department of Internal Medicine I, Rudolfstiftung Hospital, Juchgasse 25, 1030 Vienna, Austria. katarzyna.krzyzanowska@wienkav.at
Mittermayer
Friedrich
F
Krugluger
Walter
W
Kopp
Hans Peter
HP
Schernthaner
Guntram
G
D000328:Adult; D015992:Body Mass Index; D002097:C-Reactive Protein; D015331:Cohort Studies; D016207:Cytokines / Q000097:blood*; D005260:Female; D015391:Gastroplasty / Q000379:methods*; D006801:Humans; D007328:Insulin / Q000097:blood*; D007333:Insulin Resistance; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D054409:Nicotinamide Phosphoribosyltransferase; D009767:Obesity, Morbid / Q000097:blood / Q000601:surgery*; D011446:Prospective Studies; D016896:Treatment Outcome; D015431:Weight Loss / Q000502:physiology*
D016207:Cytokines; D007328:Insulin; D015850:Interleukin-6; D002097:C-Reactive Protein; D054409:Nicotinamide Phosphoribosyltransferase; C085455:nicotinamide phosphoribosyltransferase, human