title: [An analysis of 276 cases of drug-induced liver damage].
abstract: OBJECTIVE
  Drug-induced liver damage is a potential complication from using many drugs. The aim of our study was to analyze the etiology and clinical features of drug-induced liver damage, in order to draw more attention to this problem.
  
  
  METHODS
  Two hundred and seventy-six cases over a 5-year period in Jiangsu Province Hospital were retrospectively analyzed.
  
  
  RESULTS
  A variety of drugs, including traditional Chinese medicines (26.1% of our total cases) and anticancer drugs (17%) caused liver damage. The main clinical manifestations of it were fatigue, nausea, vomiting and jaundice. In 88% of our cases the symptoms were relieved or completely disappeared, but there was still a 5.1% mortality rate.
  
  
  CONCLUSIONS
  The clinical features of drug-induced liver damage are of no specificity, and the mortality of it is not low. Liver function should be monitored when suspected drugs are prescribed.
authors.affiliation: Department of Infectious Diseases, First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China.
authors.forename: Wei-ting
authors.initials: WT
authors.lastname: Lu
authors.forename: Jun
authors.initials: J
authors.lastname: Li
authors.forename: Ning
authors.initials: N
authors.lastname: Ou
authors.forename: Nian
authors.initials: N
authors.lastname: Chen
authors.forename: Yuan
authors.initials: Y
authors.lastname: Liu
authors.forename: Xue-jiang
authors.initials: XJ
authors.lastname: Guo
authors.forename: Rui-yun
authors.initials: RY
authors.lastname: Wang
authors.forename: Xiang
authors.initials: X
authors.lastname: Lu
authors.forename: Jun
authors.initials: J
authors.lastname: Huang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D056487:Chemical and Drug Induced Liver Injury, Chronic / Q000145:classification* / Q000175:diagnosis / Q000209:etiology; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D055815:Young Adult