[Effect of low-level irradiation on incidence rate and development of malignant neoplasms].
Low-level irradiation (1.2-2.4 cGy, dose-rate 0.6 cGy/day) leads to a significant acceleration of the development of spontaneous leukosis in AKR mice: decrease in the average and the maximum life-span of animals leukosis-carriers (by 20 and 120 days, respectively) and an increase in the leukosis incidence rate (%). The introduction of antioxidant phenozan (beta-(4-hydroxy-3,5-ditertbutylphenyl) propionic acid) results in a considerable antileukosis effect: the average life-span increases by more than 40 days and the leukosis incidence rate decreases by 6%.
Burlakova
E B
EB
Erokhin
V N
VN
Semenov
V A
VA
D000818:Animals; D017849:Animals, Inbred Strains; D000975:Antioxidants / Q000008:administration & dosage; D004307:Dose-Response Relationship, Radiation; D005720:Gamma Rays / Q000009:adverse effects*; D007953:Leukemia, Radiation-Induced / Q000401:mortality / Q000517:prevention & control; D008136:Longevity / Q000187:drug effects / Q000528:radiation effects; D051379:Mice; D010640:Phenothiazines / Q000008:administration & dosage; D015996:Survival Rate
D000975:Antioxidants; D010640:Phenothiazines; C031637:phenothiazine