title: Does edaravone (MCI- 186) act as an antioxidant and a neuroprotector in experimental traumatic brain injury?
abstract: Edaravone (MCI-186) is a novel synthetic free radical scavenger intended to have neuroprotective effect against ischemic insult. It is currently used on patients with cerebral infarction. Here, we note beneficial pharmaceutical effects of edaravone in rat experimental traumatic brain injury. Under specific experimental conditions, edaravone minimized traumatic brain injury by functioning as a synthetic antioxidant. Clinical trials testing the efficacy of edaravone are warranted.
authors.affiliation: Showa University, Department of Emergency and Critical Care Medicine, Tokyo, Japan. kdop@med.showa-u.ac.jp
authors.forename: Kenji
authors.initials: K
authors.lastname: Dohi
authors.forename: Kazue
authors.initials: K
authors.lastname: Satoh
authors.forename: Tomoya
authors.initials: T
authors.lastname: Nakamachi
authors.forename: Sachiko
authors.initials: S
authors.lastname: Yofu
authors.forename: Keisuke
authors.initials: K
authors.lastname: Hiratsuka
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Nakamura
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Ohtaki
authors.forename: Toshikazu
authors.initials: T
authors.lastname: Yoshikawa
authors.forename: Seiji
authors.initials: S
authors.lastname: Shioda
authors.forename: Tohru
authors.initials: T
authors.lastname: Aruga
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D000983:Antipyrine / Q000031:analogs & derivatives* / Q000494:pharmacology; D001769:Blood / Q000378:metabolism; D001930:Brain Injuries / Q000188:drug therapy*; D000077553:Edaravone; D016166:Free Radical Scavengers / Q000494:pharmacology; D006801:Humans; D015227:Lipid Peroxidation; D009474:Neurons / Q000473:pathology; D018696:Neuroprotective Agents / Q000494:pharmacology; D009569:Nitric Oxide / Q000737:chemistry; D051381:Rats; D017382:Reactive Oxygen Species; D013997:Time Factors; D024502:alpha-Tocopherol / Q000737:chemistry
chemical_list: D000975:Antioxidants; D016166:Free Radical Scavengers; D018696:Neuroprotective Agents; D017382:Reactive Oxygen Species; D009569:Nitric Oxide; D024502:alpha-Tocopherol; D000077553:Edaravone; D000983:Antipyrine