title: Asymptomatic primary hyperparathyroidism.
abstract: Primary hyperparathyroidism is a common disorder of mineral metabolism characterized by incompletely regulated, excessive secretion of parathyroid hormone from one or more of the parathyroid glands. In adults with the disease, a single, benign adenoma is seen approximately 80 percent of the time, with multiple gland involvement comprising most of the remaining patients. Very rarely, a parathyroid cancer is responsible but it is seen in less than 0.5 percent of patients with primary hyperparathyroidism. In this article, we will review important clinical and diagnostic features of asymptomatic primary hyperparathyroidism as well as considerations for surgical or medical management of the disease.
authors.affiliation: Division of Endocrinology, Department of Medicine, College of Physicians & Surgeons, Columbia University, New York, NY 10032, USA. jpb2@columbia.edu
authors.forename: John P
authors.initials: JP
authors.lastname: Bilezikian
authors.forename: Mishaela
authors.initials: M
authors.lastname: Rubin
authors.forename: Shonni J
authors.initials: SJ
authors.lastname: Silverberg
mesh_terms: D015415:Biomarkers / Q000097:blood; D015519:Bone Density; D006801:Humans; D049950:Hyperparathyroidism, Primary / Q000097:blood / Q000175:diagnosis* / Q000601:surgery; D010281:Parathyroid Hormone / Q000097:blood; D014807:Vitamin D / Q000097:blood; D014808:Vitamin D Deficiency / Q000097:blood
chemical_list: D015415:Biomarkers; D010281:Parathyroid Hormone; D014807:Vitamin D