Study of peptide dendrimers having a ferrocene core supported on mercaptoundecanoic acid.
Hydrogen-bonding interactions between the carboxylic acid groups of mercaptoundecanoic acid (MUA) coated gold substrates and the ester surface of peptide dendrimers allows the formation of glutamic acid dendrimers films. Dendrimer films were prepared for generations 1-6 (G1-G6) and analyzed by spectroscopic and electrochemical techniques. Electrochemical studies using cyclic voltammetry and differential pulse voltammetry show that all films except those of G6 were electrochemically active. Lack of activity of G6 films is rationalized by the total encapsulation of the ferrocene redox probe by the dendritic sheath and lack of ion pairing, which prevents its oxidation.
Appoh
Francis E
FE
Department of Chemistry, University of Saskatchewan, 110 Science Place, Saskatoon, Saskatchewan, Canada S7N 5C9.
Long
Yi-Tao
YT
Kraatz
Heinz-Bernhard
HB
D050091:Dendrimers / Q000737:chemistry*; D005227:Fatty Acids / Q000737:chemistry*; D005296:Ferrous Compounds / Q000737:chemistry*; D006046:Gold / Q000737:chemistry; D000075163:Metallocenes; D015394:Molecular Structure; D010455:Peptides / Q000138:chemical synthesis / Q000737:chemistry*; D013438:Sulfhydryl Compounds / Q000737:chemistry*; D013499:Surface Properties
C505222:11-mercaptoundecanoic acid; D050091:Dendrimers; D005227:Fatty Acids; D005296:Ferrous Compounds; D000075163:Metallocenes; D010455:Peptides; D013438:Sulfhydryl Compounds; D006046:Gold; C004998:ferrocene