title: High times for memory: cannabis disrupts temporal coordination among hippocampal neurons.
abstract: Exogenous cannabinoid receptor agonists impair hippocampus-dependent learning and decrease the power of hippocampal electroencephalographic activity. A new paper shows that cannabinoids desynchronize neuronal assemblies without affecting average firing rates, and that this effect correlates with memory deficits in individuals.
authors.affiliation: Department of Anatomy & Neurobiology, University of California, Irvine, California 92697, USA.
authors.forename: Ivan
authors.initials: I
authors.lastname: Soltesz
authors.forename: Kevin
authors.initials: K
authors.lastname: Staley
mesh_terms: D000818:Animals; D063385:Cannabinoid Receptor Modulators / Q000494:pharmacology; D002186:Cannabinoids / Q000494:pharmacology*; D003344:Cortical Synchronization / Q000187:drug effects*; D006624:Hippocampus / Q000166:cytology / Q000187:drug effects*; D006801:Humans; D008568:Memory / Q000187:drug effects; D009474:Neurons / Q000187:drug effects*; D043882:Receptors, Cannabinoid / Q000145:classification / Q000187:drug effects / Q000502:physiology; D009435:Synaptic Transmission / Q000187:drug effects*; D013997:Time Factors
chemical_list: D063385:Cannabinoid Receptor Modulators; D002186:Cannabinoids; D043882:Receptors, Cannabinoid