title: Overt diabetes mellitus in a patient with combined primary aldosteronism and Cushing's syndrome.
abstract: Although there are some case reports of combined aldosterone and cortisol producing adrenal tumor, overt diabetes mellitus has been rarely described. A 55-year-old hypertensive woman had hypokalemia and overt hyperglycemia without Cushingoid clinical features. The body mass index was 18.2 kg/m2, fasting blood glucose was 302 mg/dl and hemoglobin A1c was 11.6%. Endogenous insulin secretion was well preserved, whereas insulin sensitivity measured by short insulin tolerance test was markedly impaired. A solitary left aldosterone- and cortisol-producing adrenal tumor was diagnosed. We described a rare case of overt diabetes mellitus in a patient with combined primary aldosteronism and Cushing's syndrome.
authors.affiliation: Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka.
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Sasaki
authors.forename: Masanori
authors.initials: M
authors.lastname: Iwase
authors.forename: Hisatomi
authors.initials: H
authors.lastname: Arima
authors.forename: Sakae
authors.initials: S
authors.lastname: Nohara
authors.forename: Sachiko
authors.initials: S
authors.lastname: Bandai
authors.forename: Takashi
authors.initials: T
authors.lastname: Yao
authors.forename: Koji
authors.initials: K
authors.lastname: Fujii
authors.forename: Mitsuo
authors.initials: M
authors.lastname: Iida
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000150:complications / Q000175:diagnosis / Q000601:surgery; D003480:Cushing Syndrome / Q000150:complications / Q000175:diagnosis* / Q000601:surgery; D048909:Diabetes Complications / Q000150:complications / Q000175:diagnosis / Q000601:surgery; D003920:Diabetes Mellitus / Q000175:diagnosis* / Q000601:surgery; D005260:Female; D006801:Humans; D006929:Hyperaldosteronism / Q000150:complications / Q000175:diagnosis* / Q000601:surgery; D008875:Middle Aged