title: [Graves-Basedow disease after allogeneic bone marrow transplantation].
abstract: One severe aplastic anaemia case who presented autoimmune thyroid disease after allogeneic bone marrow transplantation (alloBMT) is described. A 19 year old Polish girl developed Graves' hyperthyroidisms 19 months after allogeneic BMT for severe aplastic anaemia (SAA) donated from her brother. Her serum was positive for thyroid stimulating antibody (TSAb) and anti-thyroid peroxidase autoantibodies (aTPO) while her brother remained euthyroid, seronegative for TSAb, and showed no clinical signs of thyroid pathology. The genetic studies of lymphocytes FISH (fluorescence in situ hybridization) and analysis of STR (short tandem repeated) fragments suggested, that lymphocytes responsible for hyperthyroidisms were of donor origin.
authors.affiliation: Department and Clinic of Hematology Collegium Medicum, Jagiellonian University, Cracov, Poland. gils@poczta.onet.pl
authors.forename: Beata
authors.initials: B
authors.lastname: Jakubas
authors.forename: Marta
authors.initials: M
authors.lastname: Kostecka-Matyja
authors.forename: Andrzej
authors.initials: A
authors.lastname: Darczuk
authors.forename: Justyna
authors.initials: J
authors.lastname: Gil
mesh_terms: D000328:Adult; D000741:Anemia, Aplastic; D001323:Autoantibodies / Q000097:blood; D016026:Bone Marrow Transplantation / Q000009:adverse effects* / Q000276:immunology*; D005260:Female; D006086:Graft vs Host Disease / Q000276:immunology; D006111:Graves Disease / Q000276:immunology*; D006801:Humans; D018828:Immunoglobulins, Thyroid-Stimulating / Q000097:blood*; D013967:Thyroiditis, Autoimmune / Q000276:immunology; D014184:Transplantation, Homologous / Q000009:adverse effects* / Q000276:immunology*; D016896:Treatment Outcome
chemical_list: D001323:Autoantibodies; D018828:Immunoglobulins, Thyroid-Stimulating