CaMKII, an emerging molecular driver for calcium homeostasis, arrhythmias, and cardiac dysfunction.
Maintenance of cytoplasmic calcium homeostasis is critical for all cells. An exciting field has emerged in elucidating the multiple roles that Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) plays in regulating Ca(2+) cycling in normal cardiac myocytes and in pathophysiological states. Moreover, CaMKII was recently identified as a potential drug target in cardiac disease. This work has given us a closer view of the complexity and therapeutic possibilities of CaMKII regulation of Ca(2+) signaling in cardiac myocytes.
Grueter
Chad E
CE
Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, TN, USA.
Colbran
Roger J
RJ
Anderson
Mark E
ME
D000818:Animals; D001145:Arrhythmias, Cardiac / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism*; D054732:Calcium-Calmodulin-Dependent Protein Kinase Type 2; D017871:Calcium-Calmodulin-Dependent Protein Kinases / Q000502:physiology*; D009202:Cardiomyopathies / Q000378:metabolism*; D006706:Homeostasis; D006801:Humans; D015398:Signal Transduction
D054732:Calcium-Calmodulin-Dependent Protein Kinase Type 2; D017871:Calcium-Calmodulin-Dependent Protein Kinases; D002118:Calcium