T-lymphocyte production, function, and death in children who recovered from opsoclonus-myoclonus syndrome.
Reduced CD4+ lymphocytes have been recently found in peripheral blood of children with active opsoclonus-myoclonus syndrome. The authors identified 2 children who recovered from this syndrome, one of whom showed reduced CD4+ lymphocytes 2 years after the disease onset. Except for a decrease of "naive" CD45RA+ CD4+ population and a mild restriction of T-cell heterogeneity in this patient, probably related to the immune response to viral infections, no alterations of T-cell homeostasis and function were found in either child. Therefore, the decrease of CD4+ cells may persist after clinical recovery, but the causes of this abnormality cannot be ascribed to intrinsic T-cell defects.
Sottini
Alessandra
A
Laboratorio di Biotecnologie, Spedali Civili of Brescia, Brescia, Italy.
Micheli
Roberto
R
Ghidini
Claudia
C
Valotti
Monica
M
Airò
Paolo
P
Caimi
Luigi
L
Imberti
Luisa
L
D000324:Adrenocorticotropic Hormone / Q000627:therapeutic use; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D016923:Cell Death; D049109:Cell Proliferation; D002675:Child, Preschool; D005260:Female; D006728:Hormones / Q000627:therapeutic use; D006801:Humans; D053578:Opsoclonus-Myoclonus Syndrome / Q000188:drug therapy / Q000276:immunology*
D006728:Hormones; D000324:Adrenocorticotropic Hormone