Synthesis of OSW saponin analogs with modified sugar residues and their antiproliferative activities.
Eight monosaccharide analogs of the potent antitumor OSW saponins (2-9) were synthesized. One analog, 2-O-acetyl-alpha-l-arabinopyranoside 3, showed antiproliferative activity against the Jurkat cells (IC(50)=0.078microM) comparable to that of the disaccharide derivative (1).
Tang
Pingping
P
State Key Laboratory of Bio-organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China.
Mamdani
Fatemah
F
Hu
Xiaoyi
X
Liu
Jun O
JO
Yu
Biao
B
D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis* / Q000494:pharmacology*; D002241:Carbohydrates / Q000737:chemistry*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002783:Cholestenones / Q000138:chemical synthesis* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D006801:Humans; D007202:Indicators and Reagents; D019169:Jurkat Cells; D031442:Ornithogalum / Q000737:chemistry*; D012503:Saponins / Q000138:chemical synthesis* / Q000494:pharmacology*; D013936:Thymidine / Q000378:metabolism
D000972:Antineoplastic Agents, Phytogenic; D002241:Carbohydrates; D002783:Cholestenones; D007202:Indicators and Reagents; D012503:Saponins; C106408:OSW 1; D013936:Thymidine