Primary intraspinal primitive neuroectodermal tumor treated with autologous stem cell transplantation: case report and review of the literature.
The authors describe the case of a 19-year-old female patient with a primary primitive neuroectodermal tumor (PNET) of the thoraco-lumbar spinal cord, who presented with acute urinary retention and back pain for 2 months. Magnetic resonance imaging revealed an intradural extramedullary tumor, 6.5 cm long, in the region of the conus medullaris. Histological examination disclosed a small round cell tumor with immunohistochemical characteristics of a peripheral PNET. Metastatic workup showed no evidence of an intracranial tumor or metastases outside the neuroaxis. The patient received multidisciplinary treatment, including surgical excision, irradiation of the entire cranio-spinal axis, and high-dose chemotherapy with autologous stem cell rescue. Presently, 24 months after diagnosis, the patient remains in complete remission.
Nutman
Amir
A
Israel Defense Forces, Medical Corps, Haifa, Israel.
Postovsky
Sergey
S
Zaidman
Irina
I
Elhasid
Ronit
R
Vlodavsky
Euvgeni
E
Kreiss
Yitshak
Y
Ben Arush
Myriam Weyl
MW
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007796:Laminectomy; D018242:Neuroectodermal Tumors, Primitive / Q000628:therapy*; D013125:Spinal Neoplasms / Q000628:therapy*; D033581:Stem Cell Transplantation; D014182:Transplantation, Autologous