title: Serum anti-Fcgamma receptor autoantibodies in patients with alopecia areata.
abstract: Although anti-Fcgamma receptor antibodies (Abs) are detected in various autoimmune diseases, there have been no studies about the anti-Fcgamma receptor Abs in alopecia areata (AA). To detect the anti-Fcgamma receptor Abs in patients with AA and their clinical correlations, Serum samples from 72 patients with AA and 23 normal controls were examined by enzyme-linked immunosorbent assay assessing anti-Fcgamma receptor Ab levels. Anti-Fcgamma receptor I Abs were significantly frequently detected in patients with AA compared with normal controls. Furthermore, the detection of anti-Fcgamma receptor I Abs significantly inversely correlated with the disease duration. These results suggest that anti-Fcgamma receptor I Ab and Fcgamma receptor I play an important role in the regulation of AA, are useful for a marker of the disease prognosis and are worth intense research for the reasonable and specific therapy of AA.
authors.affiliation: Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan.
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Kuwano
authors.forename: Manabu
authors.initials: M
authors.lastname: Fujimoto
authors.forename: Rei
authors.initials: R
authors.lastname: Watanabe
authors.forename: Nobuko
authors.initials: N
authors.lastname: Asashima
authors.forename: Hiroko
authors.initials: H
authors.lastname: Nakashima
authors.forename: Hiroki
authors.initials: H
authors.lastname: Ohno
authors.forename: Shoichiro
authors.initials: S
authors.lastname: Yano
authors.forename: Norihito
authors.initials: N
authors.lastname: Yazawa
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Okochi
authors.forename: Kunihiko
authors.initials: K
authors.lastname: Tamaki
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000506:Alopecia Areata / Q000097:blood* / Q000473:pathology; D015703:Antigens, CD / Q000276:immunology; D001323:Autoantibodies / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D018450:Disease Progression; D005260:Female; D058851:GPI-Linked Proteins; D006801:Humans; D008297:Male; D008875:Middle Aged; D017452:Receptors, IgG / Q000276:immunology*
chemical_list: D015703:Antigens, CD; D001323:Autoantibodies; D015415:Biomarkers; C489017:FCGR1A protein, human; C428200:FCGR3B protein, human; C080568:Fc gamma receptor IIA; C080572:Fc gamma receptor IIC; D058851:GPI-Linked Proteins; D017452:Receptors, IgG