title: Multiple malignant melanomas in association with neurofibromatosis type 1.
abstract: We present a case of multiple primary malignant melanomata occurring over a six year period in a 63-year-old Caucasian man with neurofibromatosis type 1. There is doubt regarding a definite association between these two diseases despite a number of case reports and clear, potential pathological mechanisms. This case not only strengthens support for an association but also highlights the great difficulties that arise in the management of cutaneous melanomata in patients with neurofibromatosis.
authors.affiliation: Sixways Surgery, London Road, Charlton Kings, Cheltenham, GL52 6HS, UK. drcbbarringer@hotmail.com
authors.forename: C B
authors.initials: CB
authors.lastname: Barringer
authors.forename: S J
authors.initials: SJ
authors.lastname: Gorse
authors.forename: H S
authors.initials: HS
authors.lastname: Rigby
authors.forename: C D
authors.initials: CD
authors.lastname: Reid
mesh_terms: D006801:Humans; D008297:Male; D008545:Melanoma / Q000473:pathology* / Q000601:surgery; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000473:pathology* / Q000601:surgery; D009456:Neurofibromatosis 1 / Q000473:pathology*; D012878:Skin Neoplasms / Q000473:pathology* / Q000601:surgery