Peptides targeting protein kinases: strategies and implications.
Protein kinases are important key regulators in most, if not all, biological processes and are linked with many human diseases. Protein kinases thus became attractive targets for drug design. Intracellularly active peptides that selectively interfere with kinase function and or kinase-mediated signaling pathways are potential drug compounds with therapeutic implications.
Kaidanovich-Beilin
Oksana
O
Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Ramat Aviv, Israel.
Eldar-Finkelman
Hagit
H
D000595:Amino Acid Sequence; D000818:Animals; D001667:Binding, Competitive; D015195:Drug Design; D006801:Humans; D008969:Molecular Sequence Data; D010455:Peptides / Q000235:genetics* / Q000378:metabolism* / Q000494:pharmacology; D047428:Protein Kinase Inhibitors / Q000378:metabolism* / Q000494:pharmacology; D011494:Protein Kinases / Q000378:metabolism*
D010455:Peptides; D047428:Protein Kinase Inhibitors; D011494:Protein Kinases