Paralytic ileus associated with combined atypical antipsychotic therapy.
First- and second-generation antipsychotics commonly cause mild and sometimes severe gastrointestinal motility depression. We discuss a case of a patient who developed paralytic ileus during his treatment with a combination of second-generation antipsychotics. The patient did not receive other medication that could cause depression of intestinal motility than the above-mentioned combination of antipsychotics and no other etiology could be found for the ileus. Furthermore we discuss the theoretical background of antipsychotics induced gastrointestinal motility depression and we provide the literature review of case reports of this topic.
Dome
Peter
P
National Institute for Psychiatry and Neurology, Budapest, 27 POB 1, 1281, Huvosvolgyi u 116, Hungary. dome_peter@yahoo.co.uk
Teleki
Zsofia
Z
Kotanyi
Reka
R
D014150:Antipsychotic Agents / Q000009:adverse effects*; D004359:Drug Therapy, Combination; D006801:Humans; D007418:Intestinal Pseudo-Obstruction / Q000139:chemically induced*; D008297:Male; D008875:Middle Aged; D012559:Schizophrenia / Q000188:drug therapy
D014150:Antipsychotic Agents