title: Best-evidence interventions: findings from a systematic review of HIV behavioral interventions for US populations at high risk, 2000-2004.
abstract: OBJECTIVE
  The Centers for Disease Control and Prevention's HIV/AIDS Prevention Research Synthesis Team conducted a systematic review of US-based HIV behavioral intervention research literature from 2000 through 2004 to identify interventions demonstrating best evidence of efficacy for reducing HIV risk.
  
  
  METHODS
  Standard systematic review methods were used. Each eligible study was reviewed on the basis of Prevention Research Synthesis Team efficacy criteria that focused on 3 domains: study design, implementation and analysis, and strength of evidence.
  
  
  RESULTS
  Eighteen interventions met the criteria for best evidence. Four targeted HIV-positive individuals. Of those targeting populations at risk for HIV, 4 targeted drug users, 6 targeted adults at risk because of heterosexual behaviors only, 2 targeted men who have sex with men, and 2 targeted youths at high risk. Eight interventions focused on women, and 13 had study samples with more than 50% minority participants. Significant intervention effects included increased condom use and reductions in unprotected sexual intercourse, number of sexual partners, injection drug use or needle sharing, and newly acquired sexually transmitted infections.
  
  
  CONCLUSIONS
  Most of the best-evidence interventions are directly applicable for populations in greatest need of effective prevention programs; however, important gaps still exist.
authors.affiliation: Prevention Research Branch, Division of HIV/AIDS Prevention, National Center for HIV, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Ga 30333, USA. clyles@cdc.gov
authors.forename: Cynthia M
authors.initials: CM
authors.lastname: Lyles
authors.forename: Linda S
authors.initials: LS
authors.lastname: Kay
authors.forename: Nicole
authors.initials: N
authors.lastname: Crepaz
authors.forename: Jeffrey H
authors.initials: JH
authors.lastname: Herbst
authors.forename: Warren F
authors.initials: WF
authors.lastname: Passin
authors.forename: Angela S
authors.initials: AS
authors.lastname: Kim
authors.forename: Sima M
authors.initials: SM
authors.lastname: Rama
authors.forename: Sekhar
authors.initials: S
authors.lastname: Thadiparthi
authors.forename: Julia B
authors.initials: JB
authors.lastname: DeLuca
authors.forename: Mary M
authors.initials: MM
authors.lastname: Mullins
mesh_terms: D019317:Evidence-Based Medicine; D015658:HIV Infections / Q000517:prevention & control* / Q000523:psychology; D006293:Health Promotion / Q000379:methods*; D006801:Humans; D040242:Risk Reduction Behavior; D012725:Sexual Behavior; D012749:Sexually Transmitted Diseases / Q000517:prevention & control* / Q000523:psychology; D016896:Treatment Outcome; D014481:United States