title: A causal role for the human tumor antigen preferentially expressed antigen of melanoma in cancer.
abstract: Tumor antigens are of interest as diagnostic and prognostic markers and potential therapeutic targets. The tumor antigen preferentially expressed antigen of melanoma (PRAME) is frequently overexpressed in a wide variety of cancers and is a prognostic marker for clinical outcome. It has been shown recently that PRAME functions as a repressor of retinoic acid signaling. Here, we discuss this novel insight in the context of the increasing interest in tumor antigens as targets for therapy.
authors.affiliation: Division of Molecular Carcinogenesis and Center for Biomedical Genetics, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
authors.forename: Mirjam T
authors.initials: MT
authors.lastname: Epping
authors.forename: René
authors.initials: R
authors.lastname: Bernards
mesh_terms: D000951:Antigens, Neoplasm / Q000096:biosynthesis / Q000502:physiology*; D014408:Biomarkers, Tumor / Q000096:biosynthesis; D006801:Humans; D009369:Neoplasms / Q000276:immunology*
chemical_list: D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; C404944:PRAME protein, human