title: Liver X receptor gene polymorphisms and adipose tissue expression levels in obesity.
abstract: OBJECTIVE
  LXRA and LXRB genes regulate adiposity, energy dissipation, as well as glucose and lipid homeostasis in mice. We investigated the LXR genes in human obesity.
  
  
  METHODS
  LXRA and LXRB mRNAs were quantified in abdominal subcutaneous adipose tissue of obese and nonobese women. The LXRA and LXRB genes were screened for polymorphisms and common single nucleotide polymorphisms genotyped in obese and nonobese women.
  
  
  RESULTS
  Relative LXRA mRNA expression levels were higher in obese women (P=0.03). One LXRA single nucleotide polymorphism, rs2279238, and one common haplotype, CAAGCC, as well as two LXRB single nucleotide polymorphisms, LB44732G>A and rs2695121, were associated with obesity phenotypes (nominal P values of 0.0075, 0.0014, 0.008 and 0.02, respectively). Furthermore, there was evidence of interaction between LXRA and LXRB alleles in determining body mass index.
  
  
  CONCLUSIONS
  Our results support a role for LXRA in human adipose tissue. The nominal associations of LXRA and LXRB alleles with obesity are interesting and should be further investigated in independent data sets.
authors.affiliation: Department of Medicine, Karolinska Institute, Huddinge, Stockholm, Sweden. Ingrid.Dahlman@medhs.ki.se
authors.forename: Ingrid
authors.initials: I
authors.lastname: Dahlman
authors.forename: Maria
authors.initials: M
authors.lastname: Nilsson
authors.forename: Hong
authors.initials: H
authors.lastname: Jiao
authors.forename: Johan
authors.initials: J
authors.lastname: Hoffstedt
authors.forename: Cecilia M
authors.initials: CM
authors.lastname: Lindgren
authors.forename: Keith
authors.initials: K
authors.lastname: Humphreys
authors.forename: Juha
authors.initials: J
authors.lastname: Kere
authors.forename: Jan-Ake
authors.initials: JA
authors.lastname: Gustafsson
authors.forename: Peter
authors.initials: P
authors.lastname: Arner
authors.forename: Karin
authors.initials: K
authors.lastname: Dahlman-Wright
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism*; D000328:Adult; D000483:Alleles; D001483:Base Sequence; D016022:Case-Control Studies; D017931:DNA Primers / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics*; D005260:Female; D015870:Gene Expression; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D000071518:Liver X Receptors; D008875:Middle Aged; D009765:Obesity / Q000235:genetics* / Q000378:metabolism; D057093:Orphan Nuclear Receptors; D020641:Polymorphism, Single Nucleotide; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D018160:Receptors, Cytoplasmic and Nuclear / Q000235:genetics*
chemical_list: D017931:DNA Primers; D004268:DNA-Binding Proteins; D000071518:Liver X Receptors; C000605213:NR1H3 protein, human; C000605214:Nr1h3 protein, mouse; D057093:Orphan Nuclear Receptors; D012333:RNA, Messenger; D018160:Receptors, Cytoplasmic and Nuclear