title: Multistep resistance selection and postantibiotic-effect studies of the antipneumococcal activity of LBM415 compared to other agents.
abstract: LBM415 is a peptide deformylase inhibitor active against gram-positive bacterial species and some gram-negative species. In multiselection studies, LBM415 had low MICs against all Streptococcus pneumoniae strains tested, regardless of their genotype, and selected resistant clones after 14 to 50 days. MIC increases correlated with changes mostly in the 70GXGXAAXQ77 motif in peptide deformylase. The postantibiotic effect of LBM415 ranged from 0.3 to 1.4 h.
authors.affiliation: Department of Pathology, Hershey Medical Center, P.O. Box 850, Hershey, PA 17033, USA.
authors.forename: Klaudia
authors.initials: K
authors.lastname: Kosowska-Shick
authors.forename: Kim L
authors.initials: KL
authors.lastname: Credito
authors.forename: Glenn A
authors.initials: GA
authors.lastname: Pankuch
authors.forename: Bonifacio
authors.initials: B
authors.lastname: DeWasse
authors.forename: Pamela
authors.initials: P
authors.lastname: McGhee
authors.forename: Peter C
authors.initials: PC
authors.lastname: Appelbaum
mesh_terms: D000581:Amidohydrolases / Q000235:genetics; D024881:Drug Resistance, Bacterial / Q000235:genetics; D008826:Microbial Sensitivity Tests; D010455:Peptides / Q000235:genetics / Q000494:pharmacology*; D011008:Pneumococcal Infections / Q000188:drug therapy; D013045:Species Specificity; D013296:Streptococcus pneumoniae / Q000187:drug effects* / Q000235:genetics; D013997:Time Factors
chemical_list: C487638:NVP PDF 713; D010455:Peptides; D000581:Amidohydrolases; C084507:peptide deformylase