Lower urinary tract symptoms and bladder control in advanced Parkinson's disease: effects of deep brain stimulation in the subthalamic nucleus.
Deep brain stimulation in the subthalamic nucleus (STN) leads to significant improvement in motor function in patients with advanced Parkinson's disease (PD). In this prospective study including 16 patients with PD, we investigated (1) lower urinary tract symptoms (LUTS) by questionnaires International Prostate Symptom Score (IPSS, symptoms only) and Danish Prostate Symptom Score (DanPSS, symptoms and bother of symptoms) and (2) bladder control (assessed by urodynamics) before and after implantation of electrodes in the STN. PD symptoms (Unified Parkinson's Disease Rating Scale score) improved significantly (P < 0.0001), and symptoms of overactive bladder (IPSS) decreased along with the troublesome symptoms of overactive bladder (DanPSS; P < 0.01 for both). Urodynamic parameters before and after implantation of electrodes in the STN, evaluated with and without the stimulation on, did not change significantly.
Winge
Kristian
K
Copenhagen Movement Disorders Centre, H:S Bispebjerg Hospital, Copenhagen NV, Denmark. k.winge@dadlnet.dk
Nielsen
Kurt Krøyer
KK
Stimpel
Hans
H
Lokkegaard
Annemette
A
Jensen
Steen Rusborg
SR
Werdelin
Lene
L
D000328:Adult; D000368:Aged; D046690:Deep Brain Stimulation / Q000379:methods*; D004567:Electrodes, Implanted; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000150:complications* / Q000503:physiopathology / Q000628:therapy*; D011446:Prospective Studies; D012720:Severity of Illness Index; D020531:Subthalamic Nucleus / Q000502:physiology*; D011795:Surveys and Questionnaires; D001748:Urinary Bladder Neck Obstruction / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D053201:Urinary Bladder, Overactive / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D014563:Urodynamics / Q000502:physiology; D014570:Urologic Diseases / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology