Current concepts and controversies in the treatment of alcoholic hepatitis.
The treatment of alcoholic hepatitis remains one of the most debated topics in medicine and a field of continued research. In this review, we discuss the evolution of scoring systems, including the recent development of the Glasgow alcoholic hepatitis score, role of liver biopsy and current treatment interventions. Studies of treatment interventions with glucocorticoids, pentoxifylline, infliximab, s-adenosyl-methionine, and colchicine are reviewed with discussion on quality. Glucocorticoids currently remain the mainstay of treatment for severe alcoholic hepatitis.
Rongey
Catherine
C
Robert Wood Johnson Clinical Scholars Program, University of California at Los Angeles, 911 Broxton Avenue, Los Angeles, CA 90024, USA. crongey@mednet.ucla.edu
Kaplowitz
Neil
N
D001706:Biopsy; D005938:Glucocorticoids / Q000627:therapeutic use; D006519:Hepatitis, Alcoholic / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology*; D006801:Humans; D008099:Liver / Q000473:pathology / Q000503:physiopathology; D012720:Severity of Illness Index
D005938:Glucocorticoids