title: Impaired platelet mitochondrial activity in Alzheimer's disease and mild cognitive impairment.
abstract: Mitochondrial abnormalities are found in Alzheimer's disease (AD), but previous reports have not examined at-risk groups. In subjects with AD, mild cognitive impairment (MCI), and non-demented aged controls, platelet and lymphocyte mitochondria were isolated and analyzed for Complexes I, III, and IV of the electron transport chain. Western blots were used to control for differential enrichment of samples. Results demonstrated significant declines in Complexes III and IV in AD, and a significant decline in Complex IV in MCI. This report confirms mitochondrial deficiencies in AD, extends them to MCI, and suggests they are present at the earliest symptomatic stages of disease.
authors.affiliation: Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Arizona Alzheimer's Disease Consortium, 350 W. Thomas Road, Phoenix, AZ 85013, USA. jvalla@chw.edu
authors.forename: Jon
authors.initials: J
authors.lastname: Valla
authors.forename: Lonnie
authors.initials: L
authors.lastname: Schneider
authors.forename: Tracy
authors.initials: T
authors.lastname: Niedzielko
authors.forename: Keith D
authors.initials: KD
authors.lastname: Coon
authors.forename: Richard
authors.initials: R
authors.lastname: Caselli
authors.forename: Marwan N
authors.initials: MN
authors.lastname: Sabbagh
authors.forename: Geoffrey L
authors.initials: GL
authors.lastname: Ahern
authors.forename: Leslie
authors.initials: L
authors.lastname: Baxter
authors.forename: Gene
authors.initials: G
authors.lastname: Alexander
authors.forename: Douglas G
authors.initials: DG
authors.lastname: Walker
authors.forename: Eric M
authors.initials: EM
authors.lastname: Reiman
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000378:metabolism* / Q000473:pathology*; D001792:Blood Platelets / Q000166:cytology* / Q000378:metabolism*; D003072:Cognition Disorders / Q000378:metabolism* / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008928:Mitochondria / Q000378:metabolism* / Q000473:pathology