title: Acylphloroglucinol derivatives from Hypericum prolificum.
abstract: Three new acylphloroglucinol derivatives have been isolated from the hexane extract of the aerial parts of Hypericum prolificum L.: prolificin A (1), prolifenone A (2), and prolifenone B (3). The structures were elucidated on the basis of extensive 2D NMR and MS data. All three compounds were evaluated for in vitro cell proliferation inhibitory activity against human breast (MCF-7), lung (NCI-H460), CNS (SF-268), stomach (AGS), and colon (HCT-116) tumor cell lines. Prolificin A showed growth inhibition of all cell lines with IC50 values ranging from 23 to 36 microM. Prolifenones A and B were inactive at the concentrations tested.
authors.affiliation: Department of Chemistry, Susquehanna University, 514 University Avenue, Selinsgrove, Pennsylvania 17870, USA. henry@susqu.edu
authors.forename: Geneive E
authors.initials: GE
authors.lastname: Henry
authors.forename: Smita
authors.initials: S
authors.lastname: Raithore
authors.forename: Yanjun
authors.initials: Y
authors.lastname: Zhang
authors.forename: Bolleddula
authors.initials: B
authors.lastname: Jayaprakasam
authors.forename: Muraleedharan G
authors.initials: MG
authors.lastname: Nair
authors.forename: David
authors.initials: D
authors.lastname: Heber
authors.forename: Navindra P
authors.initials: NP
authors.lastname: Seeram
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020902:Hypericum / Q000737:chemistry*; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D010414:Pennsylvania; D010696:Phloroglucinol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; C516760:prolifenone A; C516761:prolifenone B; C516759:prolificin A; D010696:Phloroglucinol