title: Oxidation studies on Andrographolide.
abstract: Jones oxidation of Andrographolide (1), gave mixture of three products (3-dehydroandrographolide (5), 3,19-bis dehydroandrographolide (6) and 19-dehydroandrographolide (7). Tritylation of andrographolide at C19-OH resulted to products 8 and diene 9, which can be converted to its acetate 10 and oxidation product 11.
authors.affiliation: Medicinal & Process Chemistry Division, Central Drug Research Institute, Lucknow-226001, India. kanwalraj12@rediffmail.com
authors.forename: Vijayavitthal T
authors.initials: VT
authors.lastname: Mathad
authors.forename: Satish
authors.initials: S
authors.lastname: Kumar
authors.forename: Kanwal
authors.initials: K
authors.lastname: Raj
mesh_terms: D000089:Acetic Anhydrides; D035685:Andrographis / Q000737:chemistry*; D004224:Diterpenes / Q000737:chemistry*; D015394:Molecular Structure; D010084:Oxidation-Reduction; D014320:Triphenylmethyl Compounds
chemical_list: D000089:Acetic Anhydrides; D004224:Diterpenes; D014320:Triphenylmethyl Compounds; C031800:acetic anhydride; C030419:andrographolide; C003723:trityl chloride