title: The effect of propofol as an antioxidant agent in intravenous regional anesthesia.
abstract: Intravenous regional anesthesia (IVRA) is a technique whereby a tourniquet is used to restrict blood flow to an exsanguinated limb. Propofol was shown to attenuate ischemia-reperfusion damage. We aimed to investigate the effect of low-dose propofol as an antioxidant in this process. Twenty-six unpremedicated adult patients (ASA I-II) were studied. The patients in the control group (Group C, n = 12) were administered 40 ml of 0.5% lidocaine, while the patients in the propofol group (Group P, n = 14) were administered 40 ml of 0.5% lidocaine plus 20 mg propofol for IVRA. Serum levels of malondialdehyde (MDA) and paraoxonase activity were measured at 1 min before, immediately upon, and 30 min after the release of the tourniquet. Serum paraoxonase activity was observed to have a significant decreasing course in both groups (p < 0.01). In contrast, we observed a progressive increase in the serum levels of MDA in Group C (p < 0.05). However, in Group P, serum levels of MDA after the release of the tourniquet periods were significantly lower than that before the release of the tourniquet (p < 0.05). The addition of propofol (20 mg) to lidocaine for IVRA inhibits MDA levels. We conclude that the addition of propofol to lidocaine can be considered as a useful antioxidant in this type of anesthesia.
authors.affiliation: Department of Anesthesiology and Reanimation, Firat University School of Medicine, Elazig, Turkey.
authors.forename: O L
authors.initials: OL
authors.lastname: Erhan
authors.forename: A
authors.initials: A
authors.lastname: Bestas
authors.forename: F
authors.initials: F
authors.lastname: Gursu
authors.forename: N
authors.initials: N
authors.lastname: Alpay
authors.forename: A B
authors.initials: AB
authors.lastname: Ozer
authors.forename: F
authors.initials: F
authors.lastname: Gulcu
mesh_terms: D000328:Adult; D000765:Anesthesia, Conduction / Q000379:methods*; D018686:Anesthetics, Intravenous / Q000008:administration & dosage / Q000627:therapeutic use; D000975:Antioxidants / Q000008:administration & dosage / Q000627:therapeutic use*; D043303:Aryldialkylphosphatase / Q000097:blood; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008012:Lidocaine / Q000008:administration & dosage / Q000627:therapeutic use; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D015742:Propofol / Q000008:administration & dosage / Q000627:therapeutic use*; D013997:Time Factors
chemical_list: D018686:Anesthetics, Intravenous; D000975:Antioxidants; D008315:Malondialdehyde; D008012:Lidocaine; D043303:Aryldialkylphosphatase; D015742:Propofol