Designer genes: Filling the gap in transplantation.
Accelerated evolution of the field of functional genomics has been greatly facilitated by high-throughput microarray-based gene function studies, relating to the parallel and serial expression measurements of genomes. Microarray experimentation is being applied for the study of basic research questions, drug target discovery, pharmacology, toxicogenomics, target selectivity, disease biomarker determination, development of prognostic tests, and disease subclass determination. This article will review the current applications of microarray technology in the field of organ transplantation and discuss the potential impact of this technology on transplantation medicine.
Sarwal
Minnie M
MM
Department of Pediatrics, Stanford University School of Medicine, Palo Alto, CA 94305, USA. msarwal@stanford.edu
Li
Li
L
D005818:Genetic Engineering / Q000639:trends*; D006084:Graft Rejection / Q000235:genetics; D006085:Graft Survival / Q000235:genetics; D006801:Humans; D016030:Kidney Transplantation / Q000276:immunology / Q000473:pathology; D005810:Multigene Family; D020411:Oligonucleotide Array Sequence Analysis; D014180:Transplantation; D014181:Transplantation Immunology; D014184:Transplantation, Homologous / Q000473:pathology