title: Alpha(2)-blocker helps to avoid systemic to pulmonary shunt in a prostaglandin dependent infant with critical pulmonary valve stenosis.
abstract: A 27 days old newborn with critical pulmonary valve stenosis remained prostaglandin (PGE(1)) dependent for 2 weeks after successful balloon valvuloplasty. Only the introduction of Phentolamine in his medication regimen, allowed PGE(1) to be weaned off within days of this therapy. The medication was continued for 4 days and replaced by angiotensin converting enzyme inhibitor (Captopril). Few weeks after the discharge, the patient remained clinically stable with acceptable saturation.
authors.affiliation: Department of Cardiovascular Diseases, Section of Pediatric Cardiology, King Faisal Specialist Hospital and RC, Jeddah, Saudi Arabia.
authors.forename: Mohammad Omar
authors.initials: MO
authors.lastname: Galal
authors.forename: Amin Muhammad
authors.initials: AM
authors.lastname: Arfi
authors.forename: Jameel Al
authors.initials: JA
authors.lastname: Ata
authors.forename: Arif
authors.initials: A
authors.lastname: Hussain
authors.forename: Amjad
authors.initials: A
authors.lastname: Kouatli
mesh_terms: D000317:Adrenergic alpha-Antagonists / Q000627:therapeutic use*; D000527:Alprostadil / Q000627:therapeutic use; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D010646:Phentolamine / Q000627:therapeutic use*; D011652:Pulmonary Circulation; D011666:Pulmonary Valve Stenosis / Q000151:congenital* / Q000188:drug therapy* / Q000503:physiopathology; D014665:Vasodilator Agents / Q000627:therapeutic use
chemical_list: D000317:Adrenergic alpha-Antagonists; D014665:Vasodilator Agents; D000527:Alprostadil; D010646:Phentolamine