An update on autonomic neuropathy affecting the gastrointestinal tract.
Gastrointestinal symptoms and disordered gut motility occur frequently in the diabetic population and are generally regarded as manifestations of gastrointestinal "autonomic dysfunction," although the relationships between both symptoms and dysmotility with abnormal cardiovascular autonomic function are weak. It is now recognized that the blood glucose concentration is both a determinant of and determined by gastrointestinal function. An improved definition of the underlying pathophysiology should facilitate the development of therapies that are targeted more effectively.
Phillips
Liza K
LK
Rayner
Christopher K
CK
Jones
Karen L
KL
Horowitz
Michael
M
D000818:Animals; D001342:Autonomic Nervous System Diseases / Q000503:physiopathology*; D001786:Blood Glucose / Q000378:metabolism; D003929:Diabetic Neuropathies / Q000453:epidemiology / Q000503:physiopathology*; D004195:Disease Models, Animal; D005746:Gastric Emptying; D041981:Gastrointestinal Tract / Q000294:innervation*; D006801:Humans
D001786:Blood Glucose