title: [Combined assay of serum prostate specific antigen and chromogranin A helps diagnosis of prostate cancer].
abstract: OBJECTIVE
  To evaluate the significance of the combined assay of chromogranin A (CgA) and prostate specific antigen (PSA) in the diagnosis of prostate cancer.
  
  
  METHODS
  Serum CgA and PSA were detected by ELISA technique in 55 cases of prostate cancer (PCa), 25 cases of benign prostate hyperplasia (BPH), and 50 cases of normal subjects (control).
  
  
  RESULTS
  The serum CgA level in the PCa group was significantly higher than those in the control and BPH groups (P < 0.05), and increased with clinical stages. The parallel and serial tests associated with serum PSA and CgA raised the rate of detection of prostate cancer.
  
  
  CONCLUSIONS
  The combined assay of serum PSA and CgA is of significant clinical value in raising the rate of diagnosis of prostate cancer, as well as in staging and prognosing the disease.
authors.affiliation: Department of Urology, First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, China. suncc379@163.com
authors.forename: Chang-Cheng
authors.initials: CC
authors.lastname: Sun
authors.forename: Wei
authors.initials: W
authors.lastname: Zheng
authors.forename: Chui-Ze
authors.initials: CZ
authors.lastname: Kong
authors.forename: Xia
authors.initials: X
authors.lastname: Wang
authors.forename: Chun-Ming
authors.initials: CM
authors.lastname: Yang
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000097:blood*; D016022:Case-Control Studies; D053379:Chromogranin A / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D017430:Prostate-Specific Antigen / Q000097:blood*; D011471:Prostatic Neoplasms / Q000175:diagnosis*; D012680:Sensitivity and Specificity
chemical_list: D014408:Biomarkers, Tumor; D053379:Chromogranin A; D017430:Prostate-Specific Antigen