title: Leukocyte profile of cattle persistently infected with bovine viral diarrhea virus.
abstract: Animals acutely infected with bovine viral diarrhea virus (BVDV) exhibit transient immunosuppression as a result of the virus' predilection for cells that play critical roles in the host immune system. Acute BVDV infections have major effects on thymic and follicular T-lymphocytes, as well as follicular B-lymphocytes, often resulting in severe reduction in circulating numbers of lymphocytes and suppression of functional activities of these cells. Granulocytes and monocytes are equally susceptible to BVDV infections with reduction in numbers and suppression functions. However, there is limited information on the leukocyte profile of cattle persistently infected (PI) with BVDV. This study reports on phagocytic activities of granulocytes and monocytes as well as immunophenotyping by flow cytometric analysis of leukocytes isolated from healthy non-PI (NPI) and PI animals. No significant differences were found between the leukocyte profiles and the phagocytic activities of PI animals when compared to a group of healthy NPI animals.
authors.affiliation: University of Wisconsin-Madison, School of Veterinary Medicine, Department of Pathobiological Sciences, 2015 Linden Dr Madison, WI 53706, USA. brewooj@svm.vetmed.wisc.edu
authors.forename: Joseph N
authors.initials: JN
authors.lastname: Brewoo
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Haase
authors.forename: Patricia
authors.initials: P
authors.lastname: Sharp
authors.forename: Ronald D
authors.initials: RD
authors.lastname: Schultz
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D000956:Antigens, Viral / Q000097:blood; D001912:Bovine Virus Diarrhea-Mucosal Disease / Q000276:immunology* / Q000821:virology; D002417:Cattle; D001908:Diarrhea Viruses, Bovine Viral / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay / Q000662:veterinary; D005260:Female; D005434:Flow Cytometry / Q000662:veterinary; D006098:Granulocytes / Q000276:immunology; D007958:Leukocyte Count / Q000662:veterinary; D007962:Leukocytes / Q000276:immunology* / Q000821:virology; D016131:Lymphocyte Subsets / Q000276:immunology* / Q000821:virology; D009000:Monocytes / Q000276:immunology; D009500:Neutralization Tests / Q000662:veterinary; D010587:Phagocytosis / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral; D000956:Antigens, Viral