title: Isolation of tetraprenyltoluquinols from the brown alga Sargassum thunbergii.
abstract: Thunbergols A (4) and B (5), tetraprenyltoluquinols, along with three known compounds (1-3) have been isolated from the brown alga Sargassum thunbergii. The structures of these two new compounds were determined to be 9-(3,4-dihydro-2,8-dimethyl-6-hydroxy-2H-1-benzopyran-2-yl)-6-methyl-2-(4-methyl-3-pentenyl)-(2E,6E)-nonadienoic acid (4) and 10-(2,3-dihydro-5-hydroxy-7-methyl-1-benzofuran-2-yl)-10-hydroxy-6-methyl-2-(4-methyl-3-pentenyl)-(2E,6E)-undecadienoic acid (5), respectively, by combined spectroscopic methods. Both of them exhibited significant scavenging activities on radical and potently inhibited generation of ONOO(-) from morpholinosydnonimine (SIN-1).
authors.affiliation: Division of Marine Environment and Bioscience, Korea Maritime University, Busan 606-791, Korea. ywseo@hhu.ac.kr
authors.forename: Youngwan
authors.initials: Y
authors.lastname: Seo
authors.forename: Ki Eui
authors.initials: KE
authors.lastname: Park
authors.forename: You Ah
authors.initials: YA
authors.lastname: Kim
authors.forename: Hee-Jung
authors.initials: HJ
authors.lastname: Lee
authors.forename: Jong-Su
authors.initials: JS
authors.lastname: Yoo
authors.forename: Jong-Woong
authors.initials: JW
authors.lastname: Ahn
authors.forename: Burm-Jong
authors.initials: BJ
authors.lastname: Lee
mesh_terms: D001572:Benzofurans / Q000737:chemistry*; D001578:Benzopyrans / Q000737:chemistry*; D016166:Free Radical Scavengers / Q000737:chemistry; D006873:Hydroquinones / Q000737:chemistry*; D008967:Molecular Biology; D017382:Reactive Oxygen Species / Q000737:chemistry; D044647:Sargassum / Q000737:chemistry*
chemical_list: C516821:10-(2,3-dihydro-5-hydroxy-7-methyl-1-benzofuran-2-yl)-10-hydroxy-6-methyl-2-(4-methyl-3-pentenyl)-2,6-undecadienoic acid; C516820:9-(3,4-dihydro-2,8-dimethyl-6-hydroxy-2H-1-benzopyran-2-yl)-6-methyl-2-(4-methyl-3-pentenyl)-2,6-nonadienoic acid; D001572:Benzofurans; D001578:Benzopyrans; D016166:Free Radical Scavengers; D006873:Hydroquinones; D017382:Reactive Oxygen Species