Controlling regiochemistry in Negishi carboaluminations. Fine tuning the ligand on zirconium.
The species on the zirconocene catalyst is changed from two Cp's to the Brintzinger ligand and catalytic amounts of MAO are used to usually effect a >99% regiocontrol of Negishi carboaluminations of 1-alkynes in toluene.
Lipshutz
Bruce H
BH
Department of Chemistry & Biochemistry, University of California, Santa Barbara, California 93106, USA. lipshutz@chem.ucsb.edu
Butler
Tom
T
Lower
Asher
A