title: Intrasaccular combination of metallic coils and onyx liquid embolic agent for the endovascular treatment of cerebral aneurysms.
abstract: OBJECTIVE
  The aim of this study was to report on a novel technique in which metallic embolization coils were combined with the Onyx liquid embolic agent in the aneurysm sac to achieve a more durable result after endovascular treatment. This therapeutic procedure was performed in selected cases in which, based on the authors' experiences, either coil embolization or Onyx alone would likely have failed. The authors report long-term clinical and angiographic follow-up results in 20 consecutive intracranial aneurysms treated using this combination for defined indications.
  
  
  METHODS
  Twenty aneurysms in 20 patients were treated with a combination of embolic coils and Onyx. Four aneurysms were giant; 13, large; and three, small. This new technique was used when standard Onyx or coil treatment with balloon assistance was determined to involve a higher possibility of recanalization, because either an adjunctive stent insertion could not be performed or the Onyx technique could not be used due to an unsuccessful seal test or intraaneurysm balloon prolapse. In one case, an adjunctive stent was placed before coil placement and Onyx deposition to control the material in the sac of the aneurysm, which had a fusiform neck. All aneurysms were completely occluded after using this technique. No clinical or technical adverse events occurred in any of the cases. Follow-up angiography was performed in all patients: 3-year studies in six patients, 2-year studies in five, and 1-year studies in nine. None of these studies demonstrated aneurysm regrowth or parent artery occlusion.
  
  
  CONCLUSIONS
  The combination of the embolic coils and the Onyx liquid embolic agent provides very durable aneurysm occlusion for defined indications.
authors.affiliation: Department of Radiology, Hacettepe University Hospital, Ankara, Turkey. cekirgesaatci@superonline.com
authors.forename: H Saruhan
authors.initials: HS
authors.lastname: Cekirge
authors.forename: Isil
authors.initials: I
authors.lastname: Saatci
authors.forename: Serdar
authors.initials: S
authors.lastname: Geyik
authors.forename: Kivilcim
authors.initials: K
authors.lastname: Yavuz
authors.forename: Halil
authors.initials: H
authors.lastname: Oztürk
authors.forename: Gülsün
authors.initials: G
authors.lastname: Pamuk
mesh_terms: D000293:Adolescent; D000328:Adult; D021721:Balloon Occlusion; D004121:Dimethyl Sulfoxide / Q000008:administration & dosage*; D004621:Embolization, Therapeutic / Q000295:instrumentation / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D002532:Intracranial Aneurysm / Q000000981:diagnostic imaging / Q000628:therapy*; D008297:Male; D008670:Metals; D008875:Middle Aged; D011145:Polyvinyls / Q000008:administration & dosage*; D011859:Radiography; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D008670:Metals; C450660:Onyx copolymer; D011145:Polyvinyls; D004121:Dimethyl Sulfoxide