Obesity and asthma: implications for treatment.
OBJECTIVE
Epidemiological data as well as data from mouse models of asthma indicate a relationship between obesity and asthma. The purpose of this review is to evaluate recent data addressing this relationship and its biological basis, and to evaluate the implications of these data for treatment.


RESULTS
Obesity increases the prevalence, incidence, and possibly severity of asthma, while weight loss in the obese improves asthma outcomes. Obesity also influences asthma control and the response to standard asthma therapeutics. Moreover, obese mice exhibit innate airway hyperresponsiveness and increased responses to common asthma triggers. The biological basis for the relationship between obesity and asthma may be the result of common etiologies, comorbidities, effects of obesity on lung volume, or adipokines such as tumor necrosis factor alpha, leptin, and adiponectin.


CONCLUSIONS
Understanding the mechanistic basis for the relationship between obesity and asthma may lead to new therapeutic strategies for treatment of this susceptible population.
Shore
Stephanie A
SA
Molecular and Integrative Physiological Sciences Program, Harvard School of Public Health, Boston, Massachusetts 02115, USA. sshore@hsph.harvard.edu
D000818:Animals; D018927:Anti-Asthmatic Agents / Q000627:therapeutic use; D001249:Asthma / Q000453:epidemiology / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy*; D016535:Bronchial Hyperreactivity / Q000188:drug therapy / Q000503:physiopathology; D004195:Disease Models, Animal; D006801:Humans; D051379:Mice; D008820:Mice, Obese; D009765:Obesity / Q000150:complications* / Q000453:epidemiology / Q000503:physiopathology; D015995:Prevalence; D012307:Risk Factors; D015431:Weight Loss / Q000502:physiology
D018927:Anti-Asthmatic Agents