title: Distribution of genotypes of Porphyromonas gingivalis in type 2 diabetic patients with periodontitis in Mexico.
abstract: OBJECTIVE
  To determine and compare the distribution of Porphyromonas gingivalis fimA genotypes in type 2 diabetes mellitus (T2DM) patients affected by periodontitis, using non-diabetic subjects with and without periodontitis as control groups.
  
  
  METHODS
  This study involved 75 subjects divided into three groups of 25 subjects each: Group 1 (non-T2DM without periodontitis), Group 2 (non-T2DM with periodontitis) and Group 3 (T2DM with periodontitis). The outcome variable was periodontitis, and explanatory variables were age, sex, T2DM and specific P. gingivalis fimA genotypes.
  
  
  RESULTS
  In non-T2DM subjects with healthy periodontal tissues, type I fimA was the most frequently detected individually (40%) or in combinations (40%). In non-T2DM subjects with periodontitis, the most frequently detected type was Ib individually (20%) or in combinations (36%). In T2DM patients with periodontitis, the most frequently detected types were types I (20%) and III (20%), but there was no statistical difference (p>0.05) with non-T2DM periodontitis subjects.
  
  
  CONCLUSIONS
  Type I genotype was more frequently detected in periodontally healthy sites from non-T2DM subjects than in periodontitis sites from either subjects with or without T2DM. However, in sites affected by periodontitis from T2DM subjects the predominating types were I and III, which are less virulent strains of P. gingivalis.
authors.affiliation: The Master's Degree in Dental Science with Specialization in Advanced General Dentistry Program at San Luis Potosi University, Mexico.
authors.forename: Claudia
authors.initials: C
authors.lastname: Davila-Perez
authors.forename: Atsuo
authors.initials: A
authors.lastname: Amano
authors.forename: Angel Gabriel
authors.initials: AG
authors.lastname: Alpuche-Solis
authors.forename: Nuria
authors.initials: N
authors.lastname: Patiño-Marin
authors.forename: America Patricia
authors.initials: AP
authors.lastname: Pontigo-Loyola
authors.forename: Shigeyuki
authors.initials: S
authors.lastname: Hamada
authors.forename: Juan Pablo
authors.initials: JP
authors.lastname: Loyola-Rodriguez
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D002908:Chronic Disease; D003924:Diabetes Mellitus, Type 2 / Q000382:microbiology*; D005260:Female; D036781:Fimbriae Proteins / Q000145:classification / Q000235:genetics; D005838:Genotype; D006801:Humans; D008297:Male; D008800:Mexico; D008875:Middle Aged; D017622:Periodontal Attachment Loss / Q000382:microbiology; D010514:Periodontal Pocket / Q000382:microbiology; D010518:Periodontitis / Q000382:microbiology*; D018933:Pili, Sex / Q000145:classification / Q000235:genetics; D016966:Porphyromonas gingivalis / Q000235:genetics* / Q000472:pathogenicity; D012737:Sex Factors; D014774:Virulence
chemical_list: C063055:fimbrillin; D036781:Fimbriae Proteins