title: Immunohistochemical analysis of survivin expression in thyroid follicular adenoma and carcinoma.
abstract: Survivin is one of the 8 members of human inhibitor of apoptosis , which is differentially expressed in cancerous/transformed cells versus normal differentiated tissues. This retrospective study of thyroid histologic samples aimed to assess the clinical usefulness of survivin immunostaining for discrimination between follicular adenoma and carcinoma of thyroid. Immunohistochemical staining for survivin was performed on 41 lesions from patients who had undergone surgery for either follicular adenoma or carcinoma of thyroid. Survivin expression was significantly (P < 0.005) higher in the cases that received a diagnosis of carcinoma in comparison with follicular adenomas cases. Odds ratio of follicular carcinoma for survivin expression was 21.375 (95% CI: 3.283 to 139.177). Our results showed potential value of survivin in discrimination between follicular thyroid adenoma and follicular thyroid carcinoma. We conclude that survivin is a potential candidate for further investigation in the proper histologic diagnosis of thyroid cancers.
authors.affiliation: Endocrinology and Metabolism Research Center (EMRC), Shariati Hospital, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
authors.forename: Vahid
authors.initials: V
authors.lastname: Haghpanah
authors.forename: Peiman
authors.initials: P
authors.lastname: Shooshtarizadeh
authors.forename: Ramin
authors.initials: R
authors.lastname: Heshmat
authors.forename: Bagher
authors.initials: B
authors.lastname: Larijani
authors.forename: Seyed Mohamad
authors.initials: SM
authors.lastname: Tavangar
mesh_terms: D018263:Adenocarcinoma, Follicular / Q000175:diagnosis / Q000378:metabolism* / Q000473:pathology; D000236:Adenoma / Q000175:diagnosis / Q000378:metabolism* / Q000473:pathology; D000328:Adult; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D051034:Inhibitor of Apoptosis Proteins; D008297:Male; D008869:Microtubule-Associated Proteins / Q000378:metabolism*; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000378:metabolism*; D011446:Prospective Studies; D000077022:Survivin; D013964:Thyroid Neoplasms / Q000175:diagnosis / Q000378:metabolism* / Q000473:pathology
chemical_list: C107489:BIRC5 protein, human; D051034:Inhibitor of Apoptosis Proteins; D008869:Microtubule-Associated Proteins; D009363:Neoplasm Proteins; D000077022:Survivin