title: Multicentric reticulohistiocytosis.
abstract: Multicentric reticulohistiocytosis is a rare granulomatous disease of unknown etiology, characterized by cutaneous nodules and destructive arthritis. Skin lesions can cause significant deformity, and approximately half of affected patients develop a severe disabling arthritis. The disease is often associated with malignancy; however, the paraneoplastic nature of multicentric reticulohistiocytosis is not established. The diagnosis is confirmed by the presence of oncocytic ("ground-glass") histiocytes and multinucleated giant cells on histopathology of the cutaneous nodules and the synovial membrane.
authors.affiliation: Department of Dermatology, Brown Medical School, Rhode Island Hospital, Providence, RI 02903, USA. ani_tajirian@brown.edu
authors.forename: Ani L
authors.initials: AL
authors.lastname: Tajirian
authors.forename: Mohsin K
authors.initials: MK
authors.lastname: Malik
authors.forename: Leslie
authors.initials: L
authors.lastname: Robinson-Bostom
authors.forename: Edward V
authors.initials: EV
authors.lastname: Lally
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D001168:Arthritis / Q000150:complications / Q000000981:diagnostic imaging / Q000276:immunology*; D006644:Histiocytes / Q000473:pathology*; D015616:Histiocytosis, Non-Langerhans-Cell / Q000150:complications / Q000276:immunology / Q000473:pathology*; D006801:Humans; D006949:Hyperlipidemias / Q000150:complications; D007150:Immunohistochemistry; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D011859:Radiography; D012871:Skin Diseases / Q000000981:diagnostic imaging / Q000276:immunology / Q000473:pathology*; D014374:Tuberculin Test
chemical_list: D000970:Antineoplastic Agents; D007166:Immunosuppressive Agents