Gadolinium deposition in nephrogenic fibrosing dermopathy.
There is growing recognition of the association between the use of gadolinium-containing radiocontrast agents for magnetic resonance imaging and the serious dermal and systemic disease nephrogenic fibrosing dermopathy/nephrogenic systemic fibrosis (NFD/NSF). The pathogenesis of this entity remains unclear; however, our recent observations suggest a likely mechanism for the initial dermal manifestations of this gadolinium toxicity.
Boyd
Alan S
AS
Department of Medicine (Dermatology), Vanderbilt University, Nashville, TN 37232, USA. alan.boyd@vanderbilt.edu
Zic
John A
JA
Abraham
Jerrold L
JL
D000138:Acidosis / Q000150:complications; D000368:Aged; D001808:Blood Vessels / Q000737:chemistry; D001854:Bone Marrow Cells / Q000473:pathology; D002130:Calcium Phosphates / Q000032:analysis; D003287:Contrast Media / Q000009:adverse effects / Q000032:analysis* / Q000493:pharmacokinetics; D016572:Cyclosporine / Q000009:adverse effects; D004577:Electron Probe Microanalysis; D005260:Female; D005355:Fibrosis; D005682:Gadolinium / Q000009:adverse effects / Q000032:analysis* / Q000493:pharmacokinetics; D019698:Hepatitis C, Chronic / Q000150:complications / Q000601:surgery; D006801:Humans; D006996:Hypocalcemia / Q000150:complications; D007676:Kidney Failure, Chronic / Q000139:chemically induced / Q000150:complications / Q000628:therapy; D017093:Liver Failure / Q000150:complications / Q000601:surgery; D008279:Magnetic Resonance Imaging; D008855:Microscopy, Electron, Scanning; D008954:Models, Biological; D010710:Phosphates / Q000097:blood; D011183:Postoperative Complications / Q000209:etiology / Q000378:metabolism / Q000473:pathology; D006435:Renal Dialysis; D012867:Skin / Q000098:blood supply / Q000737:chemistry* / Q000473:pathology; D012871:Skin Diseases / Q000209:etiology / Q000378:metabolism* / Q000473:pathology
D002130:Calcium Phosphates; D003287:Contrast Media; D010710:Phosphates; D016572:Cyclosporine; C020243:calcium phosphate; D005682:Gadolinium