title: A patient with progressive multiple myeloma treated successfully with arsenic trioxide after allogeneic bone marrow transplantation.
abstract: Multiple myeloma (MM) is an incurable progressive disease. Many therapeutic options are available to delay progression, including autologous and allogeneic bone marrow transplantation. At advanced stages, MM is often refractory to treatment. We report a heavily pretreated patient with graft-versus-host disease after bone marrow transplantations, treated at a terminal stage with a modified protocol for arsenic trioxide (ATO). This patient with poor clinical status tolerated the treatment very well. He had a remarkable clinical response and achieved complete remission. The mechanisms of ATO are presented and the potential role of ATO for MM is discussed.
authors.affiliation: Department of Bone Marrow Transplantation, Hadassah Hebrew University Medical Center, Jerusalem, Israel. gesund@hadassah.org.il
authors.forename: B
authors.initials: B
authors.lastname: Gesundheit
authors.forename: M Y
authors.initials: MY
authors.lastname: Shapira
authors.forename: A
authors.initials: A
authors.lastname: Ackerstein
authors.forename: I B
authors.initials: IB
authors.lastname: Resnik
authors.forename: M
authors.initials: M
authors.lastname: Bitan
authors.forename: R
authors.initials: R
authors.lastname: Or
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D000077237:Arsenic Trioxide; D001152:Arsenicals / Q000627:therapeutic use*; D016026:Bone Marrow Transplantation; D003131:Combined Modality Therapy; D006086:Graft vs Host Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000628:therapy*; D010087:Oxides / Q000627:therapeutic use*
chemical_list: D000970:Antineoplastic Agents; D001152:Arsenicals; D010087:Oxides; D000077237:Arsenic Trioxide