ER targeting signals: more than meets the eye?
The signal sequences that target newly synthesized proteins to the endoplasmic reticulum are highly variable; however, the functional significance of this diversity has remained obscure. In this issue, Kang et al. (2006) report that variability in signal sequences allows the cell to selectively regulate the translocation of proteins into the endoplasmic reticulum in a substrate-specific manner.
Swanton
Eileithyia
E
Faculty of Life Sciences, University of Manchester, Manchester, M13 9PT, UK. lisa.swanton@manchester.ac.uk
High
Stephen
S
D000818:Animals; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D006801:Humans; D018832:Molecular Chaperones / Q000378:metabolism; D011328:Prions / Q000737:chemistry / Q000378:metabolism; D017510:Protein Folding; D021382:Protein Sorting Signals; D021381:Protein Transport
D018832:Molecular Chaperones; D011328:Prions; D021382:Protein Sorting Signals