Superporous hydrogels containing poly(acrylic acid-co-acrylamide)/O-carboxymethyl chitosan interpenetrating polymer networks.
Superporous hydrogels containing poly(acrylic acid-co-acrylamide)/O-carboxymethyl chitosan interpenetrating polymer networks (SPH-IPNs) were prepared by cross-linking O-carboxymethyl chitosan (O-CMC) with glutaraldehyde (GA) after superporous hydrogel (SPH) was synthesized. The structures of the SPH-IPNs were characterized with FT-IR, 13C-NMR and DSC. SEM, CLSM and light images revealed that the SPH-IPNs possessed both the IPN network and large numbers of pores and the cross-linked O-CMC molecules were located on the peripheries of these pores. The swelling behavior of SPH-IPNs was dependent on the O-CMC content, GA amount and cross-linking time. Due to the cross-linked O-CMC network, in vitro muco-adhesive force and mechanical properties, including compression and tensile modulus, of the SPH-IPN were greatly improved when compared with the CSPH. An enhanced loading capacity for insulin could be obtained by the SPH-IPNs as compared to non-porous hydrogel and CSPH, and more than 90% of the insulin was released within 1 h. With the improved mechanical properties, in vitro muco-adhesive force and loading capacities, the SPH-IPN may be used as a potential muco-adhesive system for peroral delivery of peptide and protein drugs.
Yin
Lichen
L
State Key Laboratory of Genetic Engineering, Department of Pharmaceutical Sciences, School of Life Sciences, Fudan University, 220 Handan Road, Shanghai 200433, China. chyin@fudan.edu.cn
Fei
Likun
L
Cui
Fuying
F
Tang
Cui
C
Yin
Chunhua
C
D000178:Acrylamides / Q000737:chemistry*; D000268:Adhesiveness; D000818:Animals; D002448:Cell Adhesion; D048271:Chitosan / Q000737:chemistry*; D019245:Compressive Strength; D004337:Drug Carriers / Q000737:chemistry*; D006244:Hardness; D020100:Hydrogels / Q000737:chemistry*; D007583:Jejunum / Q000502:physiology*; D008297:Male; D008422:Materials Testing; D009092:Mucous Membrane / Q000502:physiology*; D016062:Porosity; D051381:Rats; D017207:Rats, Sprague-Dawley
D000178:Acrylamides; D004337:Drug Carriers; D020100:Hydrogels; C431184:poly(acrylamide-co-acrylic acid); D048271:Chitosan