Spatial and temporal expression of POF1B, a gene expressed in epithelia.
Mammalian epithelia possess specialized cellular components that provide an impermeable barrier between two different environments. In particular, in the skin, mitotically dividing cells undergo a programmed set of morphological and biochemical changes leading to the establishment of the epidermal permeability barrier (EPB) to prevent escape of moisture and entrance of toxic molecules. Many different skin proteins are involved in the process but not all have been identified. We report here the results of the expression studies of a novel gene, highly and specifically expressed in the granular layer of the epidermis and in the epithelia of the oro-pharyngeal and gastro-intestinal tracts. Our data show that during mouse development Pof1b expression is activated in the external layers of the epidermis just prior to formation of the EPB.
Rizzolio
Flavio
F
DIBIT, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milano, Italy.
Bione
Silvia
S
Villa
Antonello
A
Berti
Emilio
E
Cassetti
Arianna
A
Bulfone
Alessandro
A
Tribioli
Carla
C
Toniolo
Daniela
D
D000818:Animals; D015152:Blotting, Northern; D004622:Embryo, Mammalian / Q000378:metabolism; D004817:Epidermis / Q000196:embryology* / Q000378:metabolism; D004848:Epithelium / Q000378:metabolism; D015870:Gene Expression; D006801:Humans; D051379:Mice; D008840:Microfilament Proteins / Q000235:genetics*; D011506:Proteins / Q000235:genetics* / Q000502:physiology
D008840:Microfilament Proteins; C500687:POF1B protein, human; C519668:POF1B protein, mouse; D011506:Proteins