title: Efficacy of DNA immunization with F and G protein genes of Nipah virus.
abstract: We investigated the antibody response of DNA immunization with two mammalian codon optimized envelope glycoprotein genes, F and G, of Nipah virus in a mouse model. The results indicated that G gene immunization elicited more significant specific serum IgG response and neutralization antibody response than F gene did, suggesting that the G gene DNA immunization is a potential vaccine strategy against Nipah virus.
authors.affiliation: National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Science, Harbin 150001, P.R. China.
authors.forename: Xijun
authors.initials: X
authors.lastname: Wang
authors.forename: Jinying
authors.initials: J
authors.lastname: Ge
authors.forename: Sen
authors.initials: S
authors.lastname: Hu
authors.forename: Qinghua
authors.initials: Q
authors.lastname: Wang
authors.forename: Zhiyun
authors.initials: Z
authors.lastname: Wen
authors.forename: Hualan
authors.initials: H
authors.lastname: Chen
authors.forename: Zhigao
authors.initials: Z
authors.lastname: Bu
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis; D045464:Henipavirus Infections / Q000517:prevention & control / Q000635:transmission / Q000662:veterinary*; D006801:Humans; D007114:Immunization / Q000662:veterinary; D007074:Immunoglobulin G / Q000096:biosynthesis; D051379:Mice; D045405:Nipah Virus / Q000276:immunology*; D019444:Vaccines, DNA / Q000276:immunology*; D014759:Viral Envelope Proteins / Q000276:immunology; D014760:Viral Fusion Proteins / Q000276:immunology; D014764:Viral Proteins / Q000276:immunology*; D014765:Viral Vaccines / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral; D007074:Immunoglobulin G; D019444:Vaccines, DNA; D014759:Viral Envelope Proteins; D014760:Viral Fusion Proteins; D014764:Viral Proteins; D014765:Viral Vaccines; C116204:attachment protein G