title: The GCK II and III subfamilies of the STE20 group kinases.
abstract: The Ste20 (sterile 20) proteins are a large family of serine/threonine kinases. Since their discovery a growing body of evidence has implicated them in the regulation of signaling pathways governing cell growth, cell differentiation cell death and cell volume. Approximately 30 human members have been identified based on the high degree of homology of their catalytic domain to that of the Ste20p from Saccharomyces cerevisiae. In addition to the conserved regions, there are also regions of sequence that make each of them unique. In this review we will focus on two subfamilies of the group, GCK-II and GCK-III, families that are closely related but, again, unique in their structural features and biological functions. Herein, we will present what we hope will be the current state of knowledge about these kinases, and discuss what remains to be done in order to better understand their activity and regulation.
authors.affiliation: Department of Physiology,Scholl of Medicine, University of Santiago de Compostela, A Coruña, Spain. fspombo@usc.es
authors.forename: Celia María
authors.initials: CM
authors.lastname: Pombo
authors.forename: Thomas
authors.initials: T
authors.lastname: Force
authors.forename: John
authors.initials: J
authors.lastname: Kyriakis
authors.forename: Emilio
authors.initials: E
authors.lastname: Nogueira
authors.forename: Miguel
authors.initials: M
authors.lastname: Fidalgo
authors.forename: Juan
authors.initials: J
authors.lastname: Zalvide
mesh_terms: D000818:Animals; D020134:Catalytic Domain; D004789:Enzyme Activation; D006801:Humans; D023421:Models, Animal; D017346:Protein Serine-Threonine Kinases / Q000737:chemistry / Q000145:classification / Q000502:physiology*; D015398:Signal Transduction
chemical_list: D017346:Protein Serine-Threonine Kinases