A built-in co-carcinogenic effect due to viruses involved in latent or persistent infections.
A new hypothesis for some cancers, which combines the chromosomal instability theories with a co-carcinogenic effect of viruses causing latent or persistent infection, is presented. The hypothesis incorporates the multi-step model of cancer and that pre-cancerous cells reach a state of chromosomal instability. Because of chromosomal instability, the genome of these cell lines will lead to changes from generation to generation and will face a remarkable selection pressure both from lost traits, apoptosis, and from the immune system. Viruses causing latent or persistent infections have evolved many different genes capable to evade the immune system. If these viruses are harboured in the genome of pre-cancerous cells they could provide them with "superpowers" and with genes that may assist the cells to elude the immune system. The theory explains why cancer predominantly is a disease of old age. Upon aging, the immune system becomes reduced including the ability to control and suppress the viruses that cause latent or persistent infections. The risk of cancer could thereby increase as the immune functions decrease. The theory provides new insights to the genesis of cancers.
Hersoug
Lars-Georg
LG
Research Centre for Prevention and Health, Glostrup University Hospital, 57 Nrd Ringvej, Building 84/85, DK-2600 Glostrup, Denmark. Hersoug@vip.cybersity.dk
Arnau
José
J
D000818:Animals; D002908:Chronic Disease; D003141:Communicable Diseases / Q000821:virology*; D006801:Humans; D008954:Models, Biological; D009369:Neoplasms / Q000209:etiology* / Q000821:virology; D017735:Virus Latency; D018406:Virus Physiological Phenomena; D014780:Viruses / Q000472:pathogenicity*