Adjusting and censoring electronic monitoring device data. Implications for study outcomes.
Electronic monitoring device (EMD) data are widely used to measure adherence in HIV medication adherence research. EMD data represent an objective measure of adherence and arguably provide more valid data than other methods such as self-reported measures, pill counts, and drug level concentration. Moreover, EMD data are longitudinal, include many measurements, and yield a rich data set. This article illustrates potential pitfalls associated with this measurement technique, including lack of clarity associated with EMD data, and the extent to which adherence outcomes are affected by data management decisions. Recommendations are given regarding what information should be included in publications that report results based on EMD data so as to facilitate comparisons between studies.
Fennie
Kristopher P
KP
Yale University School of Nursing New Haven, Connecticut 06536, USA. kristopher.fennie@yale.edu
Bova
Carol A
CA
Williams
Ann B
AB
D019380:Anti-HIV Agents / Q000008:administration & dosage* / Q000627:therapeutic use*; D003625:Data Collection / Q000379:methods*; D016903:Drug Monitoring; D004349:Drug Packaging / Q000295:instrumentation*; D015658:HIV Infections / Q000188:drug therapy*; D006801:Humans; D008499:Medical Records; D010349:Patient Compliance / Q000706:statistics & numerical data*; D012107:Research Design
D019380:Anti-HIV Agents