Cadmium, zinc and iron interactions in the tissues of bank vole Clethrionomys glareolus after exposure to low and high doses of cadmium chloride.
In present study, bank voles Clethrionomys glareolus were peritioneally injected with different doses of cadmium, 0, 1.5, 3.0 mg Cd/kg body mass. Animals were sacrificed on the 21st day after cadmium exposure and the liver and kidney were obtained for cadmium, zinc and iron analysis using atomic absorption spectrometry. Results showed that cadmium had accumulated in the tissues according to dosage and sex. Cadmium affected the survival and body masses of dosed females. Cadmium decreased the iron concentrations in the liver of voles, whereas zinc concentrations increased in both the kidney and liver.
Swiergosz-Kowalewska
Renata
R
Department of Ecotoxicology, Institute of Environmental Sciences, Jagiellonian University, Gronostajowa 7, 30-387, Kraków, Poland. uxswierg@cyf-kr.edu.pl
Holewa
Izabela
I
D000818:Animals; D003411:Arvicolinae; D001667:Binding, Competitive / Q000187:drug effects; D002104:Cadmium / Q000378:metabolism*; D019256:Cadmium Chloride / Q000494:pharmacology* / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D005260:Female; D007501:Iron / Q000378:metabolism*; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D009928:Organ Specificity / Q000187:drug effects; D014018:Tissue Distribution / Q000187:drug effects; D015032:Zinc / Q000378:metabolism*
D002104:Cadmium; D007501:Iron; D015032:Zinc; D019256:Cadmium Chloride