Rhinocerebral mucormycosis with orbital and intracranial extension: a case report and review of optimum management.
Rhinocerebral mucormycosis is a devastating, rapidly progressive and often fatal opportunistic fungal infection predominantly affecting individuals with underlying metabolic and/or immunological compromise. Intracranial extension of the disease has invariably been associated with mortality.We present a review of optimum management of rhinocerebral mucormycosis and a case report of sinonasal mucormycosis with intracranial and orbital extension which was treated successfully with a combination of systemic liposomal amphotericin B therapy and wide surgical debridement.
Munir
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N
Department of Otorhinolaryngology and Head & Neck Surgery, Queen's Medical Centre, Nottingham, UK. munirnazia@hotmail.com
Jones
N S
NS
D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D001927:Brain Diseases / Q000382:microbiology* / Q000601:surgery; D015821:Eye Infections, Fungal / Q000382:microbiology* / Q000628:therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D009091:Mucormycosis / Q000150:complications / Q000628:therapy*; D009668:Nose Diseases / Q000382:microbiology* / Q000601:surgery / Q000628:therapy; D009916:Orbital Diseases / Q000382:microbiology* / Q000601:surgery / Q000628:therapy; D013517:Otorhinolaryngologic Surgical Procedures / Q000379:methods; D016896:Treatment Outcome
D000935:Antifungal Agents; C068538:liposomal amphotericin B; D000666:Amphotericin B