title: Platelet-derived growth factor receptor-beta in Gorham's disease.
abstract: BACKGROUND
  A 17-year-old male presented with pain in his lower-left chest. He had no significant medical history and was previously in good health. He had a fractured ninth left anterior rib and the tenth, eleventh and twelfth ribs were absent, which was thought to be a congenital anomaly. Several months later, he presented again with back pain, an enlarging mass in the lower-left chest wall, erosion of the lateral pedicles of the lower thoracic vertebrae and pleural effusion.
  
  
  METHODS
  Physical examination, chest X-ray, MRI of the spine, incisional biopsy, serial CT imaging of the hemithorax, immunohistochemistry, flow cytometry, and enzyme-linked immunosorbent assays.
  
  
  METHODS
  Gorham's lymphangiomatosis with expression of platelet-derived growth factor receptor-beta and elevated circulating platelet-derived growth factor-BB.
  
  
  RESULTS
  Spine stabilization, thalidomide, celecoxib, interferon-alpha2b, pamidronate, zoledronate, thoracotomy, pleurectomy, talc pleurodesis, and imatinib mesylate.
authors.affiliation: University Medical Center Utrecht, The Netherlands.
authors.forename: Jeroen
authors.initials: J
authors.lastname: Hagendoorn
authors.forename: Timothy P
authors.initials: TP
authors.lastname: Padera
authors.forename: Torunn I
authors.initials: TI
authors.lastname: Yock
authors.forename: G Petur
authors.initials: GP
authors.lastname: Nielsen
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: di Tomaso
authors.forename: Dan G
authors.initials: DG
authors.lastname: Duda
authors.forename: Thomas F
authors.initials: TF
authors.lastname: Delaney
authors.forename: Henning A
authors.initials: HA
authors.lastname: Gaissert
authors.forename: Jennifer
authors.initials: J
authors.lastname: Pearce
authors.forename: Andrew E
authors.initials: AE
authors.lastname: Rosenberg
authors.forename: Rakesh K
authors.initials: RK
authors.lastname: Jain
authors.forename: David H
authors.initials: DH
authors.lastname: Ebb
mesh_terms: D000293:Adolescent; D002916:Chylothorax / Q000209:etiology; D017809:Fatal Outcome; D006801:Humans; D008204:Lymphangiosarcoma / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D008297:Male; D010015:Osteolysis, Essential / Q000150:complications* / Q000175:diagnosis; D020574:Proto-Oncogene Proteins c-sis / Q000378:metabolism*
chemical_list: D020574:Proto-Oncogene Proteins c-sis