Efficacy of celecoxib in the treatment of CNS lymphomas: an in vivo model.
OBJECTIVE
The incidence of primary central nervous system lymphomas (PCNSLs) has increased over the past several decades. Unfortunately, even with the most effective therapeutic regimen (that is, methotrexate with wholebrain radiation therapy), PCNSL recurs within a few years in more than half of the treated patients and is eventually fatal. Because PCNSL usually occurs in older patients and in those with acquired immunodeficiency syndrome, combination treatments in which both chemo- and radiation therapy are used is often poorly tolerated and results in a significant reduction in the quality of life. Recently, it has been demonstrated that the selective cyclooxygenase- 2 inhibitor celecoxib (Celebrex), can block the growth of lymphoma cells in vitro.


METHODS
To create an experimental animal model in vivo for the PCNSL study, the authors intracranially injected a human B-cell lymphoma cell line into nude mice. Their data demonstrate that this experimental model is an excellent one for human PCNSL with brain and leptomeningeal involvement. They also evaluated the feasibility of using celecoxib as a therapeutic agent in the treatment of PCNSL. Nude mice with intracranial lymphomas were treated with celecoxib contained in the animal chow. The treated animals demonstrated significantly prolonged survival times compared with the untreated animals.


CONCLUSIONS
Based on the authors' data, celecoxib may be a promising therapeutic agent for the treatment of PCNSL.
Wang
Weijun
W
Department of Neurosurgery, University of Southern California, Los Angeles, California 90033, USA.
Kardosh
Adel
A
Su
Yuzhuang S
YS
Schonthal
Axel H
AH
Chen
Thomas C
TC
D000821:Animal Feed; D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D002051:Burkitt Lymphoma / Q000188:drug therapy*; D000068579:Celecoxib; D045744:Cell Line, Tumor; D016543:Central Nervous System Neoplasms / Q000188:drug therapy*; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology*; D004195:Disease Models, Animal; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy*; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D011720:Pyrazoles / Q000494:pharmacology*; D015203:Reproducibility of Results; D013449:Sulfonamides / Q000494:pharmacology*; D015996:Survival Rate
D016861:Cyclooxygenase Inhibitors; D011720:Pyrazoles; D013449:Sulfonamides; D000068579:Celecoxib