title: CA125 expression pattern, prognosis and correlation with serum CA125 in ovarian tumor patients. From The Danish "MALOVA" Ovarian Cancer Study.
abstract: OBJECTIVE
  To determine the CA125 tissue expression levels in borderline and invasive epithelial ovarian tumor tissues. Secondly, to evaluate whether CA125 tissue expression levels correlate with clinico-pathological parameters and serum CA125 levels and finally to investigate the prognostic value of tissue CA125 expression levels in ovarian cancer (OC) patients.
  
  
  METHODS
  We designed tissue arrays (TA) and analyzed the CA125 expression in tissues from 778 Danish women with an ovarian tumor. Furthermore, corresponding preoperative blood samples obtained before surgery were collected from 382 women with OC.
  
  
  RESULTS
  Significantly more CA125 expression positive tumors (no expression vs. expression) were found in the serous subtype compared to the percentage of positive tumors in mucinous, endometroid and other subtypes for patients both with borderline ovarian tumors and with OC (p<0.00001, p<0.00001). Similarly, a positive significant correlation was found between elevated serum CA125 levels and elevated levels of CA125 tissue expression (N=382 stage I-IV OC, Spearman rho=0.31, p<0.0001) (N=206 stage III OC, Spearman rho=0.30, p<0.0001). We found a significantly shorter survival for stage III/IV OC patients with no CA125 tissue expression compared to stage III/IV OC patients with positive CA125 tissue expression (p=0.0003).
  
  
  CONCLUSIONS
  Our finding that tissue CA125 expression was lacking in late stage primary OC tumor of Danish women with poor survival may be of value in selecting patients as eligible candidates for individually based treatments.
authors.affiliation: Department of Virus, Hormones and Cancer, Institute of Cancer Epidemiology, Danish Cancer Society, Strandboulevarden 49, DK-2100 Copenhagen, Denmark. Hogdall@dadlnet.dk
authors.forename: Estrid V S
authors.initials: EV
authors.lastname: Høgdall
authors.forename: Lise
authors.initials: L
authors.lastname: Christensen
authors.forename: Susanne K
authors.initials: SK
authors.lastname: Kjaer
authors.forename: Jan
authors.initials: J
authors.lastname: Blaakaer
authors.forename: Anette
authors.initials: A
authors.lastname: Kjaerbye-Thygesen
authors.forename: Simon
authors.initials: S
authors.lastname: Gayther
authors.forename: Ian J
authors.initials: IJ
authors.lastname: Jacobs
authors.forename: Claus K
authors.initials: CK
authors.lastname: Høgdall
mesh_terms: D000328:Adult; D000368:Aged; D018394:CA-125 Antigen / Q000096:biosynthesis* / Q000097:blood; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000097:blood / Q000378:metabolism* / Q000473:pathology; D011379:Prognosis
chemical_list: D018394:CA-125 Antigen