Efficient one-pot, two-step, microwave-assisted procedure for the synthesis of polysubstituted 2-aminoimidazoles.
A microwave-assisted, one-pot, two-step protocol was developed for the construction of polysubstituted 2-aminoimidazoles. This process involves the sequential formation of imidazo[1,2-a]pyrimidinium salts from readily available 2-aminopyrimidines and alpha-bromocarbonyl compounds, followed by opening of the pyrimidine ring with hydrazine. [reaction: see text]
Ermolat'ev
Denis S
DS
Laboratory for Organic & Microwave-Assisted Chemistry (LOMAC), Department of Chemistry, University of Leuven, Celestijnenlaan 200F, B-3001 Leuven, Belgium.
Babaev
Eugene V
EV
Van der Eycken
Erik V
EV
D006834:Hydrazines / Q000737:chemistry; D007093:Imidazoles / Q000138:chemical synthesis*; D007202:Indicators and Reagents; D008872:Microwaves; D011743:Pyrimidines / Q000737:chemistry
D006834:Hydrazines; D007093:Imidazoles; D007202:Indicators and Reagents; D011743:Pyrimidines; C014973:2-aminoimidazole