Cardiac beta-adrenergic signaling: from subcellular microdomains to heart failure.
beta-adrenergic signaling plays a central role in the neurohumoral regulation of the heart and the progression of heart failure. Initially thought to be a simple linear cascade, this complex network is now recognized to utilize cross-talk with numerous other pathways, spatial compartmentation, and feedback control to coordinate cardiac electrophysiology, contractility, and adaptive remodeling. Here, we review recent basic insights and novel quantitative approaches that are leading to a more comprehensive understanding of beta-adrenergic signaling and thus motivate new therapeutic strategies for cardiac disease.
Saucerman
Jeffrey J
JJ
Department of Bioengineering, University of California-San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0412, USA.
McCulloch
Andrew D
AD
D000255:Adenosine Triphosphate / Q000378:metabolism; D002303:Cardiac Output, Low / Q000503:physiopathology*; D017868:Cyclic AMP-Dependent Protein Kinases / Q000378:metabolism; D006321:Heart / Q000503:physiopathology*; D006801:Humans; D009206:Myocardium / Q000378:metabolism; D011943:Receptors, Adrenergic, beta / Q000502:physiology*; D015398:Signal Transduction
D011943:Receptors, Adrenergic, beta; D000255:Adenosine Triphosphate; D017868:Cyclic AMP-Dependent Protein Kinases