title: The innate signaling of dangers and the dangers of innate signaling.
abstract: The innate immune system of mammals has been forged by coevolution with microbes in response to the double constraint of preserving a symbiotic interaction with commensal flora and eliminating intrusion of those commensals or invasion by pathogens. Thus, a 'sensing' network, accompanied by or lacking inflammatory responses, is controlled by elaborate mechanisms of regulation that maintain balance in the basal state. A growing number of non-Toll-like innate immune receptors is recognized as part of this surveillance network.
authors.affiliation: Unité de Pathogénie Microbienne Moléculaire, Unité INSERM 786, and the Howard Hughes Medical Institute International Program, Institut Pasteur, 75724 Paris, France. psanson@pasteur.fr
authors.forename: Philippe J
authors.initials: PJ
authors.lastname: Sansonetti
mesh_terms: D000818:Animals; D006801:Humans; D007113:Immunity, Innate; D007239:Infections / Q000276:immunology*; D018448:Models, Immunological; D015398:Signal Transduction / Q000276:immunology*; D051193:Toll-Like Receptors / Q000276:immunology*
chemical_list: D051193:Toll-Like Receptors