title: Clinical evaluation of endometriosis and differential response to surgical therapy with and without application of Oxiplex/AP* adhesion barrier gel.
abstract: OBJECTIVE
  To correlate parameters of endometriosis obtained during routine clinical evaluation with the subsequent formation of adhesions following surgical treatment by laparoscopy.
  
  
  METHODS
  Randomized, controlled, double-blind, clinical trial.
  
  
  METHODS
  Tertiary referral centers for the treatment of endometriosis.
  
  
  METHODS
  Thirty-seven patients (65 with adnexa) with stage I-III endometriosis; endometrioma-only patients were excluded.
  
  
  METHODS
  Laparoscopic surgical treatment of endometriosis, followed by randomization to Oxiplex/AP (FzioMed, Inc., San Luis Obispo, California) gel treatment (treated group) of adnexa, or surgery alone (control group); follow-up laparoscopy 6-10 weeks later.
  
  
  METHODS
  Adnexal Americn Fertility Society score, correlated with color and location of endometriosis, as well as stage of disease determined by masked review of videotapes.
  
  
  RESULTS
  Control patients with at least 50% red lesions had a greater increase in ipsilateral adnexal adhesion scores than patients with mostly black or white and/or clear lesions. Treated patients with red lesions had a greater decrease in adnexal adhesion scores than control patients. There was a correlation between baseline endometriosis stage and postoperative adhesion formation in control patients, but not treated patients.
  
  
  CONCLUSIONS
  Patients with red endometriotic lesions had greater increases in their adhesion scores than patients with only black, white, and/or clear lesions. Oxiplex/AP gel was effective in reducing adhesions, compared to surgery alone, in all groups.
authors.affiliation: Livingston Reproductive Biology Laboratories, Department of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA. dizerega@usc.edu
authors.forename: Gere S
authors.initials: GS
authors.lastname: diZerega
authors.forename: James
authors.initials: J
authors.lastname: Coad
authors.forename: Jacques
authors.initials: J
authors.lastname: Donnez
mesh_terms: D002482:Cellulose / Q000031:analogs & derivatives* / Q000627:therapeutic use; D003116:Color; D004311:Double-Blind Method; D004715:Endometriosis / Q000601:surgery*; D005260:Female; D005782:Gels / Q000627:therapeutic use; D013509:Gynecologic Surgical Procedures / Q000009:adverse effects; D006801:Humans; D010535:Laparoscopy / Q000009:adverse effects*; D011092:Polyethylene Glycols / Q000627:therapeutic use*; D000267:Tissue Adhesions / Q000517:prevention & control
chemical_list: D005782:Gels; C406630:Oxiplex; D011092:Polyethylene Glycols; D002482:Cellulose