Quantitative EEG analysis in post-traumatic anosmia.
Many objective and quantitative methods have been developed to create a procedure or a device to prove, describe and quantify olfactory deficit and anosmia, especially after a head trauma. Electrophysiological testing throughout olfactoelectroencephalography (olfactoEEG) is based on brain activity desynchronisation, and on the subsequent disappearance of alpha activity on the posterior regions after an olfactory stimulus. Yet traditional evaluation of EEG can be difficult, because of little or hardly detectable alpha activity on the posterior regions ('alpha rare'). The aim of this study was to evaluate the Olfactory Stop Reaction (OSR) by means of frequency band power calculation and subsequent topographical mapping in patients with post-traumatic anosmia, who presented 'alpha rare' EEG. Twenty-five consecutive patients, affected by anosmia caused by head trauma, were submitted to an EEG recording with olfactory stimulation. After signal processing and analysis, an Olfactory Stop Reaction was detected in 17 out of 25 patients; moreover, in these patients we detected a significant decrease in alpha band power in the occipital regions and an increase in theta band power on midline frontal and central regions after olfactory stimulation. In the remaining eight patients, no significant variation in band power was observed. In conclusion, an objective evaluation of the olfactory function with this method of automatic EEG signal analysis allows the limits given by psychophysical methods and traditional EEG to be overcome and attempts to fulfil the requirements for standardization of olfactory function evalution.
Bonanni
E
E
Department of Neurosciences, Section of Neurology, University of Pisa, Via Roma 67, 56124 Pisa, Italy. e.bonanni@neuro.med.unipi.it
Borghetti
D
D
Fabbrini
M
M
Maestri
M
M
Cignoni
F
F
Sartucci
F
F
Murri
L
L
D000328:Adult; D000368:Aged; D001930:Brain Injuries / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology; D001931:Brain Mapping / Q000379:methods; D002540:Cerebral Cortex / Q000033:anatomy & histology / Q000503:physiopathology*; D004569:Electroencephalography / Q000379:methods*; D005071:Evoked Potentials / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D000857:Olfaction Disorders / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology; D009833:Olfactory Pathways / Q000293:injuries / Q000503:physiopathology*; D011237:Predictive Value of Tests; D012815:Signal Processing, Computer-Assisted; D012903:Smell / Q000502:physiology