Placenta growth factor not vascular endothelial growth factor A or C can predict the early recurrence after radical resection of hepatocellular carcinoma.
The purpose of this study was to evaluate the relationship between the expression of PlGF in tumor tissue and clinical outcomes in HCC patients. Tumor PlGF and vascular endothelial growth factor (VEGF)-A and VEGF-C mRNA were analyzed. Results demonstrated that patients with PlGF expression levels higher than median tended to have early recurrence compared to patients with PlGF expression lower than median (P=.031). In patients with AJCC stage II-III disease, this difference was even more significant (P=.002). In contrast, VEGF-A and VEGF-C could not predict early recurrence-free survival. Since PlGF expression correlated with early recurrence of HCC, PlGF may be an important prognostic indicator in HCC.
Ho
Ming-Chih
MC
Department of Surgery, National Taiwan University Hospital, No. 7, Chung-Shan South Road, Taipei 100, Taiwan, ROC.
Chen
Chiung-Nien
CN
Lee
Hsinyu
H
Hsieh
Fon-Jou
FJ
Shun
Chia-Tung
CT
Chang
Chi-Lun
CL
Lai
Yeun-Tyng
YT
Lee
Po-Huang
PH
D001483:Base Sequence; D006528:Carcinoma, Hepatocellular / Q000473:pathology* / Q000601:surgery; D017931:DNA Primers; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology* / Q000601:surgery; D000072483:Placenta Growth Factor; D011257:Pregnancy Proteins / Q000378:metabolism*; D011379:Prognosis; D012008:Recurrence; D020133:Reverse Transcriptase Polymerase Chain Reaction; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism*; D042582:Vascular Endothelial Growth Factor C / Q000378:metabolism*
D017931:DNA Primers; C000608036:PGF protein, human; D011257:Pregnancy Proteins; D042461:Vascular Endothelial Growth Factor A; D042582:Vascular Endothelial Growth Factor C; D000072483:Placenta Growth Factor