title: Age-related increases in circulating inflammatory markers in men are independent of BMI, blood pressure and blood lipid concentrations.
abstract: OBJECTIVE
  To examine whether age-related increase in concentrations of circulating inflammatory mediators is due to concurrent increases in cardiovascular risk factors or is independent of these.
  
  
  RESULTS
  Cytokines (IL-6, IL-18), chemokines (6Ckine, MCP-1, IP-10), soluble adhesion molecules (sICAM-1, sVCAM-1, sE-selectin) and adipokines (adiponectin) were measured in the plasma of healthy male subjects aged 18-84 years (n=162). These were related to known cardiovascular risk factors (age, BMI, systolic and diastolic blood pressure, plasma total cholesterol, LDL cholesterol, HDL cholesterol and triacylglycerol concentrations) in order to identify significant associations. Plasma concentrations of sVCAM-1, sE-selectin, IL-6, IL-18, MCP-1, 6Ckine, IP-10 and adiponectin, but not sICAM-1, were significantly positively correlated with age, as well as with several other cardiovascular risk factors. The correlations with other risk factors disappeared when age was controlled for. In contrast, the correlations with age remained significant for sVCAM-1, IL-6, MCP-1, 6Ckine and IP-10 when other cardiovascular risk factors were controlled for.
  
  
  CONCLUSIONS
  Plasma concentrations of some inflammatory markers (sVCAM-1, IL-6, MCP-1, 6Ckine, IP-10) are positively correlated with age, independent of other cardiovascular risk factors. This suggests that age-related inflammation may not be driven by recognised risk factors.
authors.affiliation: Institute of Human Nutrition, School of Medicine, University of Southampton, Bassett Crescent East, Southampton, Hampshire SO16 7PX, United Kingdom. Electronic address: eam@soton.ac.uk.
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Miles
authors.affiliation: The Robert Gordon University and Rowett Research Institute, Aberdeen, United Kingdom.
authors.forename: Dinka
authors.initials: D
authors.lastname: Rees
authors.affiliation: Institute of Human Nutrition, School of Medicine, University of Southampton, Bassett Crescent East, Southampton, Hampshire SO16 7PX, United Kingdom.
authors.forename: Tapati
authors.initials: T
authors.lastname: Banerjee
authors.affiliation: Department of Preclinical Sciences "LITA Vialba", University of Milan, Milan, Italy.
authors.forename: Roberta
authors.initials: R
authors.lastname: Cazzola
authors.affiliation: School of Food Biosciences, The University of Reading, Reading, United Kingdom.
authors.forename: Sian
authors.initials: S
authors.lastname: Lewis
authors.affiliation: School of Food Biosciences, The University of Reading, Reading, United Kingdom.
authors.forename: Richard
authors.initials: R
authors.lastname: Wood
authors.affiliation: Institute of Human Nutrition, School of Medicine, University of Southampton, Bassett Crescent East, Southampton, Hampshire SO16 7PX, United Kingdom.
authors.forename: Rachael
authors.initials: R
authors.lastname: Oates
authors.affiliation: Institute of Human Nutrition, School of Medicine, University of Southampton, Bassett Crescent East, Southampton, Hampshire SO16 7PX, United Kingdom.
authors.forename: Anna
authors.initials: A
authors.lastname: Tallant
authors.affiliation: Department of Preclinical Sciences "LITA Vialba", University of Milan, Milan, Italy.
authors.forename: Benvenuto
authors.initials: B
authors.lastname: Cestaro
authors.affiliation: School of Food Biosciences, The University of Reading, Reading, United Kingdom.
authors.forename: Parveen
authors.initials: P
authors.lastname: Yaqoob
authors.affiliation: The Robert Gordon University and Rowett Research Institute, Aberdeen, United Kingdom.
authors.forename: Klaus W J
authors.initials: KWJ
authors.lastname: Wahle
authors.affiliation: Institute of Human Nutrition, School of Medicine, University of Southampton, Bassett Crescent East, Southampton, Hampshire SO16 7PX, United Kingdom.
authors.forename: Philip C
authors.initials: PC
authors.lastname: Calder
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000097:blood / Q000276:immunology*; D001794:Blood Pressure; D015992:Body Mass Index; D015815:Cell Adhesion Molecules / Q000097:blood*; D002784:Cholesterol / Q000097:blood; D003430:Cross-Sectional Studies; D016207:Cytokines / Q000097:blood*; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged
chemical_list: D052242:Adiponectin; D015815:Cell Adhesion Molecules; D016207:Cytokines; D002784:Cholesterol