Telomere dysfunction: a new player in radiation sensitivity.
Human individuals often exhibit important differences in their sensitivity to ionising radiation. Extensive literature links radiation sensitivity with impaired DNA repair which is due to a lack of correct functioning in many proteins involved in DNA-repair pathways and/or in DNA-damage checkpoint responses. Given that ionising radiation is an important and widespread diagnostic and therapeutic tool, it is important to investigate further those factors and mechanisms that underlie individual radiosensitivity. Recently, evidence is accumulating that telomere function may well be involved in cellular and organism responses to ionising radiation, broadening still further the currently complex and challenging scenario.
Genescà
Anna
A
Department of Cell Biology, Physiology and Immunology, Universitat Autònoma de Barcelona, Spain. anna.genesca@uab.es
Martín
Marta
M
Latre
Laura
L
Soler
David
D
Pampalona
Judit
J
Tusell
Laura
L
D006801:Humans; D009690:Nucleic Acid Conformation; D011835:Radiation Protection; D011836:Radiation Tolerance; D016615:Telomere / Q000737:chemistry / Q000378:metabolism* / Q000528:radiation effects*; D034501:Telomere-Binding Proteins / Q000378:metabolism
D034501:Telomere-Binding Proteins