High times for memory: cannabis disrupts temporal coordination among hippocampal neurons.
Exogenous cannabinoid receptor agonists impair hippocampus-dependent learning and decrease the power of hippocampal electroencephalographic activity. A new paper shows that cannabinoids desynchronize neuronal assemblies without affecting average firing rates, and that this effect correlates with memory deficits in individuals.
Soltesz
Ivan
I
Department of Anatomy & Neurobiology, University of California, Irvine, California 92697, USA.
Staley
Kevin
K
D000818:Animals; D063385:Cannabinoid Receptor Modulators / Q000494:pharmacology; D002186:Cannabinoids / Q000494:pharmacology*; D003344:Cortical Synchronization / Q000187:drug effects*; D006624:Hippocampus / Q000166:cytology / Q000187:drug effects*; D006801:Humans; D008568:Memory / Q000187:drug effects; D009474:Neurons / Q000187:drug effects*; D043882:Receptors, Cannabinoid / Q000145:classification / Q000187:drug effects / Q000502:physiology; D009435:Synaptic Transmission / Q000187:drug effects*; D013997:Time Factors
D063385:Cannabinoid Receptor Modulators; D002186:Cannabinoids; D043882:Receptors, Cannabinoid