[Preparation of cytarabine nanoparticle and study on the drug releasing mechanism].
Cytarabine nanoparticle was prepared through emulsion polymerization method, and its releasing properties were studied. The results showed that releasing principle complied with biexponential equation and had characteristics of sustained releasing. The pharmacokinetics in rabbits complied with two-department model. Compared with cytarabine injection, cytarabine nanoparticle had prolonged t 1/2beta and MRT and reduced CL, which showed nanoparticle could significantly prolong the retention time of Ara-C and possess significant sustained releasing character.
Zhou
Jing
J
School of Pharmacy, Sichuan University, Chengdu 610041, China.
Lin
Shu
S
Jiang
Xuehua
X
Yang
Junyi
J
D000818:Animals; D003561:Cytarabine / Q000493:pharmacokinetics*; D003692:Delayed-Action Preparations; D004339:Drug Compounding / Q000379:methods*; D053758:Nanoparticles; D011817:Rabbits
D003692:Delayed-Action Preparations; D003561:Cytarabine