Alleviation of pre-exposure of mouse brain with low-dose 12C6+ ion or 60Co gamma-ray on male reproductive endocrine damages induced by subsequent high-dose irradiation.
Irradiation has been widely reported to damage organisms by attacking on proteins, nucleic acid and lipids in cells. However, radiation hormesis after low-dose irradiation has become the focus of research in radiobiology in recent years. To investigate the effects of pre-exposure of mouse brain with low-dose (12)C6+ ion or 60Co gamma (gamma)-ray on male reproductive endocrine capacity induced by subsequent high-dose irradiation, the brains of the B6C3F1 hybrid strain male mice were irradiated with 0.05 Gy of (12)C6+ ion or 60Co gamma-ray as the pre-exposure dose, and were then irradiated with 2 Gy as challenging irradiation dose at 4 h after pre-exposure. Serum pituitary gonadotropin hormones, follicle-stimulating hormone (FSH) and luteinizing hormone (LH), testosterone, testis weight, sperm count and shape were measured on the 35th day after irradiation. The results showed that there was a significant reduction in the levels of serum FSH, LH, testosterone, testis weight and sperm count, and a significant increase in sperm abnormalities by irradiation of the mouse brain with 2 Gy of (12)C6+ ion or 60Co gamma-ray. Moreover, the effects were more obvious in the group irradiated by (12)C6+ ion than in that irradiated by 60Co gamma-ray. Pre-exposure with low-dose (12)C6+ ion or 60Co gamma-ray significantly alleviated the harmful effects induced by a subsequent high-dose irradiation.
Zhang
Hong
H
Department of Medical Physics, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, China. zhangh@impcas.ac.cn
Liu
Bing
B
Zhou
Qingming
Q
Zhou
Guangming
G
Yuan
Zhigang
Z
Li
Wenjian
W
Duan
Xin
X
Min
Fengling
F
Xie
Yi
Y
Li
Xiaoda
X
D000818:Animals; D001921:Brain / Q000528:radiation effects*; D003037:Cobalt Radioisotopes / Q000009:adverse effects*; D004307:Dose-Response Relationship, Radiation; D005640:Follicle Stimulating Hormone / Q000097:blood; D005720:Gamma Rays / Q000009:adverse effects*; D020450:Heavy Ions / Q000009:adverse effects*; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009929:Organ Size / Q000528:radiation effects; D013076:Sperm Count; D013094:Spermatozoa / Q000473:pathology / Q000528:radiation effects*; D013737:Testis / Q000473:pathology / Q000528:radiation effects*; D013739:Testosterone / Q000097:blood
D003037:Cobalt Radioisotopes; D013739:Testosterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone