title: Evidence for a link between parasite genotype and outcome of infection with Entamoeba histolytica.
abstract: The factors determining whether a person infected with Entamoeba histolytica develops disease remain obscure. To investigate whether the parasite genome contributes to the outcome, we have investigated the distribution of parasite genotypes among E. histolytica-infected individuals in Bangladesh. Samples were obtained from individuals who either were asymptomatic, had diarrhea/dysentery, or had developed a liver abscess. Genotypes were determined by using six tRNA-linked polymorphic markers, and their distributions among the three sample groups were evaluated. A significant population differentiation in the genotype distribution was found for four of the six individual markers as well as for the combined genotypes, suggesting that the parasite genome does contribute in some way to the outcome of infection with E. histolytica. The markers themselves do not indicate the nature of the underlying genetic differences, but they may be linked to loci that do have an impact on the outcome of infection.
authors.affiliation: Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, Great Britain.
authors.forename: Ibne Karim M
authors.initials: IK
authors.lastname: Ali
authors.forename: Utpal
authors.initials: U
authors.lastname: Mondal
authors.forename: Shantanu
authors.initials: S
authors.lastname: Roy
authors.forename: Rashidul
authors.initials: R
authors.lastname: Haque
authors.forename: William A
authors.initials: WA
authors.lastname: Petri
authors.forename: C Graham
authors.initials: CG
authors.lastname: Clark
mesh_terms: D000818:Animals; D002675:Child, Preschool; D004404:Dysentery, Amebic / Q000469:parasitology / Q000503:physiopathology*; D004748:Entamoeba histolytica / Q000145:classification* / Q000235:genetics* / Q000472:pathogenicity; D004749:Entamoebiasis / Q000469:parasitology / Q000503:physiopathology*; D005838:Genotype; D006801:Humans; D008101:Liver Abscess, Amebic / Q000469:parasitology / Q000503:physiopathology*; D012720:Severity of Illness Index