title: Coffee consumption and risk of myocardial infarction among older Swedish women.
abstract: Numerous studies have examined the association between coffee consumption and risk of myocardial infarction (MI), but results have been inconsistent. Case-control studies generally suggest a harmful effect of coffee drinking, whereas cohort studies have mostly shown no association. Recent studies found that coffee may lower the risk of diabetes, a major coronary risk factor. The authors prospectively examined the effect of coffee consumption on MI risk in 32,650 older Swedish women, aged 40-74 years, participating in the Swedish Mammography Cohort; 459 cases of MI developed during 165,896 person-years of follow-up from 1997 to 2002. After adjustment for age, coronary heart disease risk factors, and dietary variables, the relative risk of MI associated with drinking >/=5 cups/week versus 0-4 cups/week was 0.68 (95% confidence interval (CI): 0.43, 1.07). The authors observed a nonsignificant trend toward lower risk with higher consumption levels. Compared with that for 0-4 cups/week, the relative risks of MI were 0.84 (95% CI: 0.51, 1.38) for 5-7 cups/week, 0.65 (95% CI: 0.41, 1.03) for 2-3 cups/day, 0.64 (95% CI: 0.39, 1.04) for 4-5 cups/day, and 0.65 (95% CI: 0.37, 1.12) for >/=6 cups/day (p-trend = 0.07). Contrary to previous case-control studies, the authors concluded that coffee consumption does not increase MI risk. Coffee consumption of >/=5 cups/week was nonsignificantly inversely associated with MI risk among older Swedish women.
authors.affiliation: Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA. srosner@hsph.harvard.edu
authors.forename: Sarah A
authors.initials: SA
authors.lastname: Rosner
authors.forename: Agneta
authors.initials: A
authors.lastname: Akesson
authors.forename: Meir J
authors.initials: MJ
authors.lastname: Stampfer
authors.forename: Alicja
authors.initials: A
authors.lastname: Wolk
mesh_terms: D000328:Adult; D000368:Aged; D015992:Body Mass Index; D003069:Coffee; D015897:Comorbidity; D004032:Diet; D005260:Female; D006801:Humans; D008875:Middle Aged; D015999:Multivariate Analysis; D009203:Myocardial Infarction / Q000453:epidemiology*; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012306:Risk; D012959:Socioeconomic Factors; D013548:Sweden / Q000453:epidemiology
chemical_list: D003069:Coffee