title: A molecular epidemiological study targeting the glycoprotein gene of rabies virus isolates from China.
abstract: A group of 31 rabies viruses (RABVs), recovered primarily from dogs, one deer and one human case, were collected from various areas in China between 1989 and 2006. Complete G gene sequences determined for these isolates indicated identities of nucleotide and amino acid sequences of >or=87% and 93.8%, respectively. Phylogenetic analysis of these and some additional Chinese isolates clearly supported the placement of all Chinese viruses in Lyssavirus genotype 1 and divided all Chinese isolates between four distinct groups (I-IV). Several variants identified within the most commonly encountered group I were distributed according to their geographical origins. A comparison of representative Chinese viruses with other isolates retrieved world-wide indicated a close evolutionary relationship between China group I and II viruses and those of Indonesia while China group III viruses formed an outlying branch to variants from Malaysia and Thailand. China group IV viruses were closely related to several vaccine strains. The predicted glycoprotein sequences of these RABVs variants are presented and discussed with respect to the utility of the anti-rabies biologicals currently employed in China.
authors.affiliation: Wuhan Institute of Biological Products, Wuhan 430060, China.
authors.forename: Sheng-Li
authors.initials: SL
authors.lastname: Meng
authors.forename: Jia-Xin
authors.initials: JX
authors.lastname: Yan
authors.forename: Ge-Lin
authors.initials: GL
authors.lastname: Xu
authors.forename: Susan A
authors.initials: SA
authors.lastname: Nadin-Davis
authors.forename: Ping-Gang
authors.initials: PG
authors.lastname: Ming
authors.forename: Sheng-Ya
authors.initials: SY
authors.lastname: Liu
authors.forename: Jie
authors.initials: J
authors.lastname: Wu
authors.forename: He-Tian
authors.initials: HT
authors.lastname: Ming
authors.forename: Feng-Cai
authors.initials: FC
authors.lastname: Zhu
authors.forename: Dun-Jin
authors.initials: DJ
authors.lastname: Zhou
authors.forename: Qi-You
authors.initials: QY
authors.lastname: Xiao
authors.forename: Guan-Mu
authors.initials: GM
authors.lastname: Dong
authors.forename: Xiao-Ming
authors.initials: XM
authors.lastname: Yang
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000956:Antigens, Viral / Q000737:chemistry / Q000235:genetics*; D001483:Base Sequence; D002681:China; D003670:Deer; D004285:Dogs; D019143:Evolution, Molecular; D005260:Female; D005838:Genotype; D006023:Glycoproteins / Q000737:chemistry / Q000235:genetics*; D006031:Glycosylation; D006801:Humans; D008969:Molecular Sequence Data; D010802:Phylogeny; D011818:Rabies / Q000662:veterinary / Q000821:virology*; D011820:Rabies virus / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D016415:Sequence Alignment; D017422:Sequence Analysis, DNA; D017386:Sequence Homology, Amino Acid; D012689:Sequence Homology, Nucleic Acid; D014759:Viral Envelope Proteins / Q000737:chemistry / Q000235:genetics*
chemical_list: D000956:Antigens, Viral; D006023:Glycoproteins; D014759:Viral Envelope Proteins; C064951:glycoprotein G, Rabies virus