Association of APOE with Parkinson disease age-at-onset in women.
APOE polymorphism has received extensive attention as a risk factor for Parkinson's disease (PD), but findings have been equivocal. Analysis of APOE variants in an Australian PD case-control sample revealed a robust association between genotype and age-at-onset (AAO) of PD in women (P=0.0008). These data not only further implicate APOE in PD, but also provide a stark example of the effects that gender may play in complex disorders.
Buchanan
Daniel D
DD
University of Queensland, School of Medicine, Department of Neurology, Princess Alexandra Hospital, Brisbane, Australia.
Silburn
Peter A
PA
Prince
Jonathan A
JA
Mellick
George D
GD
D017668:Age of Onset; D000368:Aged; D000704:Analysis of Variance; D001057:Apolipoproteins E / Q000235:genetics*; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000235:genetics*; D011110:Polymorphism, Genetic; D012727:Sex Characteristics
D001057:Apolipoproteins E