In vivo plaque characterization using intravascular ultrasound-virtual histology in a porcine model of complex coronary lesions.
OBJECTIVE
To determine the accuracy of detection of different tissue types of intravascular ultrasound-virtual histology (IVUS-VH) in a porcine model of complex coronary lesions.


RESULTS
Coronary lesions were induced by injecting liposomes containing human oxidized low-density lipoprotein into the adventitia of the arteries. IVUS-VH imaging was performed in vivo at 8.2+/-1.6 weeks after injection. A total of 60 vascular lesions were analyzed and compared with their correspondent IVUS-VH images. Correlation analysis was performed using linear regression models. Compared with histology, IVUS-VH correctly identified the presence of fibrous, fibro-fatty, and necrotic tissue in 58.33%, 38.33%, and 38.33% of lesions, respectively. The sensitivity of IVUS-VH for the detection of fibrous, fibro-fatty, and necrotic core tissue was 76.1%, 46%, and 41.1% respectively. A linear regression analysis performed for each individual plaque component did not show strong correlation that would allow significant prediction of individual values.


CONCLUSIONS
In a porcine model of complex coronary lesions, IVUS-VH was not accurate in detecting the relative amount of specific plaque components within each individual corresponding histological specimen.
Granada
Juan F
JF
The Methodist Hospital Research Institute, The Methodist DeBakey Heart Center, Houston, TX 77584, USA. jgranada@tmh.tmc.edu
Wallace-Bradley
David
D
Win
Htut K
HK
Alviar
Carlos L
CL
Builes
Angela
A
Lev
Eli I
EI
Barrios
Roberto
R
Schulz
Daryl G
DG
Raizner
Albert E
AE
Kaluza
Greg L
GL
D000818:Animals; D016893:Carotid Stenosis / Q000000981:diagnostic imaging* / Q000209:etiology / Q000473:pathology*; D003331:Coronary Vessels / Q000000981:diagnostic imaging / Q000473:pathology; D004195:Disease Models, Animal; D006652:Histological Techniques / Q000379:methods; D007150:Immunohistochemistry; D016014:Linear Models; D008081:Liposomes; D015588:Observer Variation; D012680:Sensitivity and Specificity; D013552:Swine; D018084:Ultrasonography, Interventional / Q000379:methods*; D014584:User-Computer Interface
D008081:Liposomes