Identification of a novel G245R polymorphism in the IL-2 receptor beta membrane proximal domain associated with human visceral leishmaniasis.
Binding of the interleukin-2 (IL-2) to the IL-2 receptor (IL-2R) triggers a series of intracellular events culminating in lymphocyte proliferation and differentiation. We report here the identification of a novel G245R polymorphism in the membrane proximal domain of the IL-2 receptor beta chain (IL-2Rbeta). Present at a frequency of 7.2%, the IL-2-Rbeta G245R was identified in a population of Eastern Sudan exposed to a severe outbreak of visceral leishmaniasis (VL), a disease associated with a marked depression of T-cell antigen-specific responses. The location of the G245R polymorphism next to the box1/box2 proximal cytokine receptor homology segment and suggestive genetic association with the development of disease (P=0.043), suggest that it may affect Janus kinase (JAK) association and impair growth signal transduction. However, additional genetic association with a synonymous single nucleotide polymorphism (IL2RB+8777T) suggests that other variations of IL2RB or nearby genes participate in the highly significant linkage with VL at 22q12 previously reported for this population.
Bucheton
B
B
1INSERM U399 Immunologie et Génétique des Maladies Parasitaires, Faculté de Médecine La Timone, Marseille, France. bucheton@mpl.ird.fr
Argiro
L
L
Chevillard
C
C
Marquet
S
S
Kheir
M M
MM
Mergani
A
A
El-Safi
S H
SH
Dessein
A J
AJ
D019943:Amino Acid Substitution; D020022:Genetic Predisposition to Disease; D006801:Humans; D053646:Interleukin-2 Receptor beta Subunit / Q000737:chemistry / Q000235:genetics*; D053612:Janus Kinases / Q000378:metabolism; D007898:Leishmaniasis, Visceral / Q000235:genetics* / Q000276:immunology*; D020641:Polymorphism, Single Nucleotide; D017434:Protein Structure, Tertiary; D015398:Signal Transduction; D013397:Sudan
D053646:Interleukin-2 Receptor beta Subunit; D053612:Janus Kinases