title: Spinal cord compression in a patient with multiple hereditary exostoses caused by breast adenocarcinoma metastatic to osteochondromas of the spine: case report.
abstract: METHODS
  Case report.
  
  
  OBJECTIVE
  To report on thoracic spinal cord compression caused by a mass in a 66-year-old female with new onset of myelopathic symptoms and a history of multiple hereditary exostoses.
  
  
  BACKGROUND
  To our knowledge, there have been no previous reports of spinal cord compression in a patient with multiple hereditary exostoses caused by breast adenocarcinoma metastatic to osteochondromas of the spine. METHODS.: Chart, pathologic, and radiographic documentation of the preoperative and postoperative clinical course of the patient was used.
  
  
  RESULTS
  The patient had resolution of her neurologic symptoms following wide surgical excision, decompression, and stabilization from T2 to T10. The patient's mass was found to be breast adenocarcinoma metastatic to osteochondromas of the spine.
  
  
  CONCLUSIONS
  When faced with a patient with a history of multiple hereditary exostoses with new onset of myelopathic symptoms and a mass compressing the spinal cord, the clinician's differential should be broad and always initially include a metastatic lesion, osteochondroma, or chondrosarcoma.
authors.affiliation: Spine Surgery and Orthopaedic Oncology Services, Department of Orthopaedics, University of Pennsylvania Medical School, Philadelphia, PA 19104, USA.
authors.forename: Nirav K
authors.initials: NK
authors.lastname: Pandya
authors.forename: Joshua D
authors.initials: JD
authors.lastname: Auerbach
authors.forename: Keith
authors.initials: K
authors.lastname: Baldwin
authors.forename: Richard D
authors.initials: RD
authors.lastname: Lackman
authors.forename: Kingsley R
authors.initials: KR
authors.lastname: Chin
mesh_terms: D000230:Adenocarcinoma / Q000150:complications / Q000000981:diagnostic imaging / Q000556:secondary* / Q000601:surgery; D000368:Aged; D000911:Antibodies, Monoclonal / Q000008:administration & dosage; D061067:Antibodies, Monoclonal, Humanized; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000188:drug therapy; D016190:Carboplatin / Q000008:administration & dosage; D002813:Chondrosarcoma / Q000175:diagnosis; D003131:Combined Modality Therapy; D019299:Decompression, Surgical; D003937:Diagnosis, Differential; D005097:Exostoses, Multiple Hereditary / Q000150:complications* / Q000601:surgery; D005260:Female; D006801:Humans; D007796:Laminectomy; D008113:Liver Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000556:secondary; D008175:Lung Neoplasms / Q000556:secondary / Q000601:surgery; D009382:Neoplasms, Unknown Primary / Q000175:diagnosis* / Q000188:drug therapy; D017239:Paclitaxel / Q000008:administration & dosage; D013117:Spinal Cord Compression / Q000209:etiology* / Q000601:surgery; D013123:Spinal Fusion; D013125:Spinal Neoplasms / Q000150:complications / Q000000981:diagnostic imaging / Q000556:secondary* / Q000601:surgery; D013904:Thoracic Vertebrae / Q000473:pathology / Q000601:surgery*; D014057:Tomography, X-Ray Computed; D000068878:Trastuzumab
chemical_list: D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D016190:Carboplatin; D000068878:Trastuzumab; D017239:Paclitaxel