Uncatalyzed and solvent-free multicomponent process for the synthesis of biphenyl-2-carbonitrile derivatives.
An innovative route to prepare a number of variously substituted new biphenyl derivatives is presented here. The protocol avoids the use of a catalyst, an organic solvent, and dry conditions. [reaction: see text]
Fringuelli
Francesco
F
CEMIN--Dipartimento di Chimica, Università di Perugia, Via Elce di Sotto 8, I-06123 Perugia, Italy.
Girotti
Rugiada
R
Piermatti
Oriana
O
Pizzo
Ferdinando
F
Vaccaro
Luigi
L
D000447:Aldehydes / Q000138:chemical synthesis; D001713:Biphenyl Compounds / Q000138:chemical synthesis*; D002625:Chemistry, Organic / Q000295:instrumentation; D007202:Indicators and Reagents; D008670:Metals / Q000737:chemistry; D008968:Molecular Conformation; D009570:Nitriles / Q000138:chemical synthesis*; D013696:Temperature; D014867:Water
D000447:Aldehydes; D001713:Biphenyl Compounds; D007202:Indicators and Reagents; D008670:Metals; D009570:Nitriles; D014867:Water