A case of isolated Nocardia asteroides brain abscess in a kidney transplant recipient.
Because of the immunosuppressive drugs used after organ transplantation, there is an increased rate of certain infections and malignancies. Nocardia brain abscess is a rare condition, seen most commonly among immunocompromised patients. It may be confused with intracranial tumors and requires long-term combined antibiotic therapy after drainage.


METHODS
A patient who underwent renal transplantation because of end-stage renal disease of unknown origin was shown to have a nocardial brain abscess while she was taking immunosuppressive drugs. The patient was given combined antibiotics and the abscess drained surgically. After 2 months, antibiotic therapy was continued with one drug. Neither a complication nor clinical or radiological sequelae occurred in this patient.


CONCLUSIONS
When central nervous system findings are observed in renal transplant recipients, nocardial brain abscess must be considered in the differential diagnosis. Recommended treatment duration is 6 to 12 months with frequent imaging.
Oztürk
S
S
Division of Nephrology, Istanbul, Faculty of Medicine, Istanbul University, Istanbul, Turkey. savasozturkdr@yahoo.com
Tufan
F
F
Alişir
S
S
Görçin
S
S
Güven
D
D
Cağatay
A
A
Türkmen
A
A
D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use; D001922:Brain Abscess / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007676:Kidney Failure, Chronic / Q000601:surgery / Q000628:therapy; D016030:Kidney Transplantation / Q000009:adverse effects / Q000276:immunology; D008279:Magnetic Resonance Imaging; D008795:Metronidazole / Q000627:therapeutic use; D009617:Nocardia Infections / Q000188:drug therapy*; D009616:Nocardia asteroides; D011183:Postoperative Complications / Q000382:microbiology; D006435:Renal Dialysis; D016896:Treatment Outcome
D000935:Antifungal Agents; D007166:Immunosuppressive Agents; D008795:Metronidazole