title: Therapeutic potential of interfering with apelin signalling.
abstract: The apelin receptor is a G protein-coupled receptor activated by several apelin fragments. Its tissue distribution suggests that apelin signalling is involved in a broad range of physiological functions. Endothelial cells, which express high levels of apelin receptors, respond to apelin through the phosphorylation of key intracellular effectors associated with cell proliferation and migration. In addition, apelin is a mitogen for endothelial cells and exhibits angiogenic properties in matrigel experiments. This review focuses on the therapeutic potential of apelin signalling, which is associated with pathologies that result from decreased vascularisation (ischemias) or neovascularisation (retinopathies and solid tumors).
authors.affiliation: IFR31, Unité INSERM U-589, CHU Rangueil, Bât. L3, BP84225, 1 avenue Jean-Poulhès, 31432-Toulouse Cédex 4, France.
authors.forename: S Caroline
authors.initials: SC
authors.lastname: Sorli
authors.forename: Loïc
authors.initials: L
authors.lastname: van den Berghe
authors.forename: Bernard
authors.initials: B
authors.lastname: Masri
authors.forename: Bernard
authors.initials: B
authors.lastname: Knibiehler
authors.forename: Yves
authors.initials: Y
authors.lastname: Audigier
mesh_terms: D000075244:Apelin Receptors; D015195:Drug Design; D004730:Endothelium, Vascular / Q000187:drug effects / Q000503:physiopathology; D006801:Humans; D009389:Neovascularization, Pathologic / Q000503:physiopathology / Q000517:prevention & control; D043562:Receptors, G-Protein-Coupled / Q000037:antagonists & inhibitors / Q000502:physiology*; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology*
chemical_list: C104575:APLNR protein, human; D000075244:Apelin Receptors; D043562:Receptors, G-Protein-Coupled