Multicentric reticulohistiocytosis.
Multicentric reticulohistiocytosis is a rare granulomatous disease of unknown etiology, characterized by cutaneous nodules and destructive arthritis. Skin lesions can cause significant deformity, and approximately half of affected patients develop a severe disabling arthritis. The disease is often associated with malignancy; however, the paraneoplastic nature of multicentric reticulohistiocytosis is not established. The diagnosis is confirmed by the presence of oncocytic ("ground-glass") histiocytes and multinucleated giant cells on histopathology of the cutaneous nodules and the synovial membrane.
Tajirian
Ani L
AL
Department of Dermatology, Brown Medical School, Rhode Island Hospital, Providence, RI 02903, USA. ani_tajirian@brown.edu
Malik
Mohsin K
MK
Robinson-Bostom
Leslie
L
Lally
Edward V
EV
D000970:Antineoplastic Agents / Q000627:therapeutic use; D001168:Arthritis / Q000150:complications / Q000000981:diagnostic imaging / Q000276:immunology*; D006644:Histiocytes / Q000473:pathology*; D015616:Histiocytosis, Non-Langerhans-Cell / Q000150:complications / Q000276:immunology / Q000473:pathology*; D006801:Humans; D006949:Hyperlipidemias / Q000150:complications; D007150:Immunohistochemistry; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D011859:Radiography; D012871:Skin Diseases / Q000000981:diagnostic imaging / Q000276:immunology / Q000473:pathology*; D014374:Tuberculin Test
D000970:Antineoplastic Agents; D007166:Immunosuppressive Agents