title: Association of APOE with Parkinson disease age-at-onset in women.
abstract: APOE polymorphism has received extensive attention as a risk factor for Parkinson's disease (PD), but findings have been equivocal. Analysis of APOE variants in an Australian PD case-control sample revealed a robust association between genotype and age-at-onset (AAO) of PD in women (P=0.0008). These data not only further implicate APOE in PD, but also provide a stark example of the effects that gender may play in complex disorders.
authors.affiliation: University of Queensland, School of Medicine, Department of Neurology, Princess Alexandra Hospital, Brisbane, Australia.
authors.forename: Daniel D
authors.initials: DD
authors.lastname: Buchanan
authors.forename: Peter A
authors.initials: PA
authors.lastname: Silburn
authors.forename: Jonathan A
authors.initials: JA
authors.lastname: Prince
authors.forename: George D
authors.initials: GD
authors.lastname: Mellick
mesh_terms: D017668:Age of Onset; D000368:Aged; D000704:Analysis of Variance; D001057:Apolipoproteins E / Q000235:genetics*; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000235:genetics*; D011110:Polymorphism, Genetic; D012727:Sex Characteristics
chemical_list: D001057:Apolipoproteins E