title: Changes of plasma asymmetric dimethylarginine levels after coronary artery bypass grafting.
abstract: OBJECTIVE
  We investigated whether coronary artery bypass grafting affects plasma asymmetric dimethylarginine (ADMA) concentrations and whether precardioplegic hyperoxia influences ADMA release from the heart.
  
  
  METHODS
  Twenty two patients were randomized into control (n = 11) and hyperoxia (n = 11, ventilated with >96% oxygen before cardiopulmonary bypass) groups. Arterial and coronary sinus blood was sampled before cardioplegia and during early reperfusion. Arterial samples were drawn 60 min after declamping of the aorta, and on the first postoperative day.
  
  
  RESULTS
  Baseline arterial values of ADMA were not different between groups (0.59+/-0.18 micro mol/l control, 0.63+/-0.13 micro mol/l hyperoxia group). Negligible release of ADMA into coronary sinus was detected 20 min after cardioplegia. A significant decrease of arterial ADMA was observed by the first postoperative morning (0.42+/-0.16 micro mol/l in control, and 0.38+/-0.07 in hyperoxia group, p < 0.01 compared to baseline).
  
  
  CONCLUSIONS
  CABG with cardioplegia is associated with decrease of ADMA by the first postoperative morning. Reperfusion of cardioplegic heart did not result in significant release of ADMA. Pretreatment with hyperoxia had no influence on myocardial release and arterial levels of ADMA.
authors.affiliation: Institute of Biochemistry, University of Tartu, Estonia. inga@mini.li.ttu.ee
authors.forename: Inga
authors.initials: I
authors.lastname: Karu
authors.forename: Kersti
authors.initials: K
authors.lastname: Zilmer
authors.forename: Joel
authors.initials: J
authors.lastname: Starkopf
authors.forename: Mihkel
authors.initials: M
authors.lastname: Zilmer
mesh_terms: D001120:Arginine / Q000031:analogs & derivatives* / Q000097:blood / Q000378:metabolism; D002315:Cardiopulmonary Bypass; D001026:Coronary Artery Bypass / Q000379:methods; D003327:Coronary Disease / Q000097:blood* / Q000378:metabolism / Q000601:surgery*; D005260:Female; D006324:Heart Arrest, Induced; D006801:Humans; D018496:Hyperoxia / Q000097:blood; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism; D011184:Postoperative Period; D013997:Time Factors
chemical_list: C018524:N,N-dimethylarginine; D001120:Arginine