title: Tuberculin skin testing is useful in the screening for nontuberculous mycobacterial cervicofacial lymphadenitis in children.
abstract: BACKGROUND
  We evaluated the diagnostic usefulness of tuberculin skin testing in the screening for nontuberculous mycobacterial (NTM) infection in children.
  
  
  METHODS
  We enrolled 180 children who had chronic cervicofacial lymphadenitis in our study. Skin testing was done using antigens of Mycobacterium tuberculosis, Mycobacterium avium, Mycobacterium kansasii, and Mycobacterium scrophulaceum. The reference standard for NTM infection was a positive culture result, identification by PCR, or both. Receiver operating characteristic analysis was used to identify the optimal cutoff point in skin induration for the detection of NTM infection. Accuracy of the mycobacterial skin tests was quantified using sensitivity and specificity rates and positive and negative predictive values at the optimal skin induration cutoff.
  
  
  RESULTS
  A total of 112 NTM infections were identified, of which 83 were caused by M. avium, 21 by Mycobacterium haemophilum, and 8 by other NTM species. At the optimal cutoff for a positive test (5 mm), tuberculin skin testing had a sensitivity and specificity of 70% and 98%, respectively, and a positive predictive value and a negative predictive value of 98% and 64%, respectively, compared with a sensitivity and a specificity of 93% and 97%, respectively; M. avium sensitin, the best-performing skin test, had positive and negative predictive values of 98% and 90%, respectively.
  
  
  CONCLUSIONS
  Tuberculin skin testing could be valuable as a first step in the diagnostic analysis of cervicofacial lymphadenitis in children without a history of TB exposure or bacille Calmette-Guérin vaccination.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Academic Medical Center, University of Amsterdam, Amsterdam, 1105 AZ, The Netherlands. j.a.lindeboom@amc.uva.nl
authors.forename: Jerome A
authors.initials: JA
authors.lastname: Lindeboom
authors.forename: Ed J
authors.initials: EJ
authors.lastname: Kuijper
authors.forename: Jan M
authors.initials: JM
authors.lastname: Prins
authors.forename: Elisabeth S
authors.initials: ES
authors.lastname: Bruijnesteijn van Coppenraet
authors.forename: Robert
authors.initials: R
authors.lastname: Lindeboom
mesh_terms: D002648:Child; D006801:Humans; D008199:Lymphadenitis / Q000175:diagnosis*; D008403:Mass Screening; D009164:Mycobacterium Infections / Q000175:diagnosis; D009162:Mycobacterium avium; D018393:Mycobacterium haemophilum; D012680:Sensitivity and Specificity; D012882:Skin Tests; D014374:Tuberculin Test