Studies on 66,67Ga- and 199Tl-poly(N-vinylpyrrolidone) complexes.
Gallium and thallium radionuclides have both diagnostic and therapeutic applications in the field of nuclear medicine. Poly(N-vinylpyrrolidone) (PVP) is routinely used as a drug base because of its excellent biocompatibility. In this paper, complex formation abilities between no-carrier-added (66,)(67)Ga/(199)Tl radionuclides and PVP have been studied. It has been found that aqueous 5% PVP solution can almost quantitatively back extract (66,)(67)Ga/(199)Tl radionuclides from an organic phase, which proves the complexing ability of PVP with (66,)(67)Ga/(199)Tl. Tl(3+) is more efficient to form Tl-PVP complexes than Tl(+). However, Tl(3+)-PVP complexes are less stable than Ga(3+)-PVP complexes.
Lahiri
Susanta
S
Chemical Sciences Division, Saha Institute of Nuclear Physics, 1/AF, Bidhannagar, Kolkata 700064, India. susanta.lahiri@saha.ac.in <susanta.lahiri@saha.ac.in>
Sarkar
Soumi
S
D005710:Gallium Radioisotopes / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry*; D011205:Povidone / Q000737:chemistry*; D019275:Radiopharmaceuticals / Q000138:chemical synthesis*; D013794:Thallium Radioisotopes / Q000737:chemistry*
D005710:Gallium Radioisotopes; D009942:Organometallic Compounds; D019275:Radiopharmaceuticals; D013794:Thallium Radioisotopes; D011205:Povidone