title: Sperm chromosome analysis in two cases of paracentric inversion.
abstract: OBJECTIVE
  To examine sperm meiotic segregation in men with paracentric inversions.
  
  
  METHODS
  Cases reports, literature review.
  
  
  METHODS
  Departments of reproductive biology, cytogenetics, gynaecology, and obstetrics.
  
  
  METHODS
  Two patients referred for infertility, heterozygous for a paracentric inversion.
  
  
  METHODS
  Fluorescence in situ hybridization (FISH) with specific probes and X/Y/18 centromeric probes on 1,000 spermatozoa for the 2 patients and 10 controls.
  
  
  METHODS
  Sperm aneuploidy frequency.
  
  
  RESULTS
  The FISH analysis using the specific probes for the paracentric inversion indicated low disequilibrium (0.4% and 0.5%). The FISH analysis using X/Y/18 centromeric probes indicated aneuploidy frequencies (0.3% and 1.1%), identical to those of control patients with the same sperm parameters.
  
  
  CONCLUSIONS
  Paracentric inversion seems to be associated with a very low risk of aneuploidy. A larger study is necessary to explore all chromosome inversions.
authors.affiliation: Departments of reproductive biology, cytogenetics, gynaecology and obstetrics, CHIPS, Poissy, France; INSERM U407, Oullins, France. fvialard@hotmail.com <fvialard@hotmail.com>
authors.forename: François
authors.initials: F
authors.lastname: Vialard
authors.forename: Audoin
authors.initials: A
authors.lastname: Delanete
authors.forename: Patrice
authors.initials: P
authors.lastname: Clement
authors.forename: Brigitte
authors.initials: B
authors.lastname: Simon-Bouy
authors.forename: François Xavier
authors.initials: FX
authors.lastname: Aubriot
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Selva
mesh_terms: D000328:Adult; D007446:Chromosome Inversion / Q000235:genetics*; D041321:Chromosomes, Human, X / Q000235:genetics*; D041322:Chromosomes, Human, Y / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D007248:Infertility, Male / Q000235:genetics*; D008297:Male; D012729:Sex Chromosome Aberrations; D013094:Spermatozoa / Q000002:abnormalities* / Q000648:ultrastructure*