title: Uteroplacental circulation in early pregnancy complicated by threatened abortion supplemented with vaginal micronized progesterone or oral dydrogesterone.
abstract: OBJECTIVE
  To compare the influence of vaginal micronized progesterone and oral dydrogesterone supplementation on uteroplacental circulation in early pregnancy that is complicated by threatened abortion.
  
  
  METHODS
  Randomized, parallel group, double-blind, double dummy-controlled study.
  
  
  METHODS
  Tertiary care university hospital.
  
  
  METHODS
  Fifty-three patients with threatened abortion and a living embryo.
  
  
  METHODS
  Three hundred milligrams of micronized vaginal progesterone or 30 mg of oral dydrogesterone daily supplementation for 6 weeks, serial transvaginal Doppler ultrasound measurement of pulsatility index, resistance index, and systolic/diastolic ratio of the spiral arteries, the uterine arteries, and the intrachorionic area.
  
  
  METHODS
  Uteroplacental blood flow.
  
  
  RESULTS
  The study demonstrated that vaginal progesterone administration, but not oral dydrogesterone treatment, results in the decrease in the spiral artery pulsatility and resistance index and systolic/diastolic ratio. Insignificant decrease in pulsatility index and resistance index of the uterine artery was observed at >9 weeks and was not associated with treatment regimen. Dydrogesterone treatment was only accompanied by the decrease in the uterine artery systolic/diastolic ratio.
  
  
  CONCLUSIONS
  Vaginal progesterone and oral dydrogesterone supplementation have a different influence on the uteroplacental circulation in early pregnancy that is complicated by threatened abortion.
authors.affiliation: Second Department of Obstetrics and Gynecology, Medical University of Warsaw, Warsaw, Poland.
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Czajkowski
authors.forename: Jacek
authors.initials: J
authors.lastname: Sienko
authors.forename: Mariusz
authors.initials: M
authors.lastname: Mogilinski
authors.forename: Magdalena
authors.initials: M
authors.lastname: Bros
authors.forename: Roman
authors.initials: R
authors.lastname: Szczecina
authors.forename: Anna
authors.initials: A
authors.lastname: Czajkowska
mesh_terms: D000033:Abortion, Threatened / Q000000981:diagnostic imaging / Q000188:drug therapy*; D000282:Administration, Intravaginal; D000284:Administration, Oral; D000328:Adult; D001158:Arteries; D001783:Blood Flow Velocity; D004311:Double-Blind Method; D004394:Dydrogesterone / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D021041:Placental Circulation / Q000187:drug effects*; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011374:Progesterone / Q000008:administration & dosage*; D018617:Ultrasonography, Doppler, Pulsed
chemical_list: D011374:Progesterone; D004394:Dydrogesterone