SEPPIC vaccine adjuvants for poultry.
Two inactivated antigens (Newcastle and Pasteurella Multocida) were formulated with different adjuvants and tested in two separate experiments in poultry. Oil formulations constituting water in oil (W/O) or water in oil in water (W/O/W) emulsions were assessed for antibody response, protection, local reactions, and vaccine physicochemical parameters. Robust, efficacious, and safe formulations were obtained with W/O formulations whereas W/O/W was especially safe with maintained efficacy. Results show that it is possible to improve traditional Tween Span formulations for safety and efficacy parameters by using Montanide ISA 70 for W/O formulations and Montanide ISA 206 for W/O/W when safety is the priority.
Dupuis
L
L
SEPPIC, 75 quai d'Orsay, 75321 Paris, Cedex 07, France. laurent.dupuis@airliquide.com
Ascarateil
S
S
Aucouturier
J
J
Ganne
V
V
D000276:Adjuvants, Immunologic; D000818:Animals; D001428:Bacterial Vaccines / Q000276:immunology; D002645:Chickens; D004655:Emulsions; D009521:Newcastle Disease / Q000517:prevention & control*; D009522:Newcastle disease virus / Q000276:immunology*; D009821:Oils / Q000737:chemistry; D010326:Pasteurella Infections / Q000517:prevention & control / Q000662:veterinary*; D016979:Pasteurella multocida / Q000276:immunology*; D011201:Poultry Diseases / Q000517:prevention & control*; D012449:Safety; D016896:Treatment Outcome; D014611:Vaccination; D014765:Viral Vaccines / Q000276:immunology; D014867:Water / Q000737:chemistry
D000276:Adjuvants, Immunologic; D001428:Bacterial Vaccines; D004655:Emulsions; D009821:Oils; D014765:Viral Vaccines; D014867:Water