Another job for the talented p120-catenin.
Given the complexity of signaling pathways in the cell, it is a mystery how these pathways communicate with one other. In this issue of Cell, Wildenberg et al. (2006) reveal that the key effector molecule p120-catenin can mediate crosstalk between the Rac and Rho signaling pathways.
Niessen
Carien M
CM
Center for Molecular Medicine Cologne (CMMC), University of Cologne, Joseph Stelzmannstrasse 9, 50931 Cologne. carien.niessen@uni-koeln.de
Yap
Alpha S
AS
D022005:Adherens Junctions / Q000378:metabolism; D000818:Animals; D051177:Catenins; D002448:Cell Adhesion; D015815:Cell Adhesion Molecules / Q000172:deficiency / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000378:metabolism; D020690:GTPase-Activating Proteins / Q000378:metabolism; D051379:Mice; D010750:Phosphoproteins / Q000172:deficiency / Q000378:metabolism*; D012097:Repressor Proteins / Q000378:metabolism; D020744:rac GTP-Binding Proteins / Q000378:metabolism; D020741:rho GTP-Binding Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism; D000095002:Delta Catenin
C513041:Arhgap35 protein, mouse; D051177:Catenins; D015815:Cell Adhesion Molecules; D004268:DNA-Binding Proteins; D020690:GTPase-Activating Proteins; D010750:Phosphoproteins; D012097:Repressor Proteins; D020744:rac GTP-Binding Proteins; D020741:rho GTP-Binding Proteins; D000095002:Delta Catenin; C000722349:Ctnnd1 protein, mouse