[Contemporary views on the pathogenesis of atherosclerosis].
Recent studies show that inflammation plays the key role inthe pathogenesis of atherosclerosis. Immune cells dominate at the initial stages of the atherosclerotic lesion of blood vessels. The effector molecules accelerate the progress of the lesion. This approach to the assessment of the pathogenesis of atherosclerosis makes it possible to search the ways for the prevention and suppression of immune inflammation. Nowadays vaccination against primary autoantigens is being successfully used for protection from experimental atherosclerosis. Modulation of immune response, involved in atherosclerosis, includes vaccination inducing immune protecting response of the development of tolerance by means of the process from Th1 to Th2 cell response.
Nagornev
V A
VA
Voskan'iants
A N
AN
D000818:Animals; D000936:Antigen-Antibody Complex / Q000276:immunology; D001161:Arteriosclerosis / Q000097:blood / Q000188:drug therapy / Q000209:etiology* / Q000276:immunology / Q000378:metabolism / Q000382:microbiology / Q000473:pathology / Q000517:prevention & control; D001324:Autoantigens / Q000276:immunology; D015551:Autoimmunity; D002784:Cholesterol / Q000097:blood; D004195:Disease Models, Animal; D006801:Humans; D006949:Hyperlipidemias / Q000150:complications; D000960:Hypolipidemic Agents / Q000627:therapeutic use; D007108:Immune Tolerance; D007249:Inflammation / Q000150:complications / Q000517:prevention & control; D050356:Lipid Metabolism; D008214:Lymphocytes / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D011817:Rabbits; D012307:Risk Factors; D018417:Th1 Cells / Q000276:immunology; D018418:Th2 Cells / Q000276:immunology; D014611:Vaccination; D014612:Vaccines / Q000627:therapeutic use
D000936:Antigen-Antibody Complex; D001324:Autoantigens; D000960:Hypolipidemic Agents; D014612:Vaccines; D002784:Cholesterol