[Auditory brainstem response in normal guinea pigs and those with gentamicin-induced hearing loss under awake and anesthetic conditions].
OBJECTIVE
To observe the alterations of auditory brainstem response (ABR) in guinea pigs with gentamicin-induced hearing loss under awake and anesthetic conditions.


METHODS
We recorded the ABR in 20 normal guinea pigs and 20 with gentamicin-induced hearing loss before and after anesthesia for statistical analysis.


RESULTS
No significant difference was observed in the waveform, response threshold (RT), I and III peak latencies (PL), I-III interpeak latencies (IPL) of ABR between awake and anesthetic conditions in normal guinea pigs (P>0.05), nor did gentamicin-induced hearing loss showed obvious impact on the ABR parameters (P>0.05).


CONCLUSIONS
No significant ABR alterations occur under awake and anesthetic conditions in either normal guinea pigs or those with hearing loss, therefore ABR test can be performed without anesthesia to ensure the success and error minimization of the experiment.
Chen
Hao
H
Department of Otorhinolaryngology and Head and Neck Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China. kitty2chh@yahoo.com.cn
Li
Yong-he
YH
Qian
Yu-hong
YH
Guo
Meng-he
MH
D000758:Anesthesia; D000818:Animals; D016057:Evoked Potentials, Auditory, Brain Stem / Q000502:physiology*; D005839:Gentamicins; D006168:Guinea Pigs; D006312:Hearing Loss, Bilateral / Q000139:chemically induced / Q000503:physiopathology*; D011897:Random Allocation; D014851:Wakefulness
D005839:Gentamicins