title: [Contact allergy to preservatives contained in cosmetics].
abstract: BACKGROUND
  The aim of this study was to assay the type of allergy to preservatives contained in cosmetics and to assess the usefulness of the composition of allergens included in a standard series for the diagnosis of occupational contact allergy used to date.
  
  
  METHODS
  The frequency of contact allergy to the standard series of preservatives (thimerosal, Euxyl K 400, formaldehyde, Kathon CG, Quaternium 15, parabens) was assayed in a group of 1937 subsequent patients referred to the Nofer Institute of Occupational Medicine in L6di and examined in the years 2000-2005. The frequency and type of allergy to preservatives of a cosmetic series in a group of 113 patients with poor tolerance of cosmetics were also investigated.
  
  
  RESULTS
  Allergy to thimerosal was found in 11.8% of patients tested with a standard series; to formaldehyde in 4.9%; and to Euxyl K 400 in 3.7%. Quaternium and parabens were less allergenic (0.8 and 0.3%, respectively). In the group of 113 patients subjected to patch test with a cosmetic series, allergy, i.e. at least one positive patch test, was observed in 49 (43.4%) patients. Of the 27 preservatives contained in cosmetics, 16 induced positive reaction to chemical compounds. Euxyl K 400 proved to be the basic allergenic preservative of this series, and induced allergy in 21 (18.6%) patients, whereas 17.7% of patients reacted to thimerosal. Only allergy to thimerosal applied to 8 persons, and 7 of them showed inflammatory lesions only on the face. Less allergic biocides were cocamidopropyl betaine (7.1%), Kathon CG (7.1%), Bronopol (5.3%), Germall II (4.4%), triethanolamine (3.5%), Germall 115 (2.6%), DMDM hydantoin (2.6%), Grotan BK (1.8%), sodium-2-pyridinethiol-1-oxide (1.8%), clioquinol (0.9%), Quaternium 15 (0.9%), and dimethylaminopropylamine (0.9%).
  
  
  CONCLUSIONS
  The results of our study confirmed observations of other authors that allergy to preservatives present in numerous industrial products, especially Euxyl K 400, is still a growing problem. Like many other researchers, we are of the opinion that this allergen should be included in a standard series for the diagnosis of all patients with suspected allergic dermatitis, including that of occupational origin.
authors.affiliation: Z Przychodni Chorób Zawodowych, Instytutu Medycyny Pracy im. prof. dra med. J. Nofera w Lodzi. marswier@imp.lodz.pl
authors.forename: Marta
authors.initials: M
authors.lastname: Kieć-Swierczyńska
authors.forename: Beata
authors.initials: B
authors.lastname: Krecisz
authors.forename: Dominika
authors.initials: D
authors.lastname: Swierczyńska-Machura
mesh_terms: D000328:Adult; D000485:Allergens / Q000032:analysis*; D003358:Cosmetics / Q000032:analysis*; D017449:Dermatitis, Allergic Contact / Q000175:diagnosis* / Q000453:epidemiology / Q000209:etiology; D009783:Dermatitis, Occupational / Q000175:diagnosis* / Q000453:epidemiology / Q000209:etiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure / Q000032:analysis; D010328:Patch Tests; D011044:Poland / Q000453:epidemiology; D011310:Preservatives, Pharmaceutical / Q000633:toxicity*
chemical_list: D000485:Allergens; D003358:Cosmetics; D011310:Preservatives, Pharmaceutical