Experimental approaches to assess metallotoxicity and ageing in models of Alzheimer's disease.
This review highlights advantages and disadvantages of experimental procedures (chemical, cellular, physiological, histochemical and epidemiological) that have been used to identify Alzheimer- and dementia-related targets for exogenous toxins, and discusses how neuronal function can be assessed experimentally, based on the evidence obtained for the neurotoxin aluminium.
Platt
Bettina
B
School of Medical Sciences, University of Aberdeen, Scotland, UK. b.platt@abdn.ac.uk
D000375:Aging / Q000502:physiology*; D000535:Aluminum / Q000378:metabolism* / Q000633:toxicity*; D000544:Alzheimer Disease / Q000378:metabolism* / Q000473:pathology*; D000818:Animals; D002118:Calcium / Q000378:metabolism; D016923:Cell Death / Q000502:physiology; D003072:Cognition Disorders / Q000175:diagnosis; D004781:Environmental Exposure / Q000009:adverse effects; D006624:Hippocampus / Q000378:metabolism* / Q000473:pathology*; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D007150:Immunohistochemistry; D015398:Signal Transduction / Q000502:physiology; D014867:Water / Q000378:metabolism
D014867:Water; D000535:Aluminum; D002118:Calcium