MHC-linked susceptibility to type 1 diabetes in the NOD mouse: further localization of Idd16 by subcongenic analysis.
Although major histocompatibility complex (MHC)-linked susceptibility is the strongest component, recent studies demonstrated that MHC-linked susceptibility to type 1 diabetes consists of multiple components both in humans and non-obese diabetic (NOD) mouse. In the NOD mouse, Idd16 has been mapped to the region adjacent to, but distinct from Idd1 in the MHC class II region. Establishment of subcongenic NOD.CTS-H2 lines that possess the same MHC class II as the NOD mouse but non-NOD-derived chromosomal region in its adjacent regions, would facilitate further narrowing down of the localization of Idd16.
Fujisawa
Tomomi
T
Department of Endocrinology, Diabetes and Metabolism, Kinki University School of Medicine, 377-2 Ohno-higashi, Sayama, Osaka 589-8511, Japan.
Ikegami
Hiroshi
H
Noso
Shinsuke
S
Yamaji
Kaori
K
Nojima
Koji
K
Babaya
Naru
N
Itoi-Babaya
Michiko
M
Hiromine
Yoshihisa
Y
Kobayashi
Misato
M
Makino
Susumu
S
Ogihara
Toshio
T
D000818:Animals; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics* / Q000276:immunology*; D005500:Follow-Up Studies; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease; D008285:Major Histocompatibility Complex / Q000235:genetics*; D051379:Mice; D020297:Mice, Congenic; D016688:Mice, Inbred NOD; D020161:Physical Chromosome Mapping; D013997:Time Factors
D005819:Genetic Markers