title: Irradiated volume and the risk of fatal hemoptysis in patients submitted to high dose-rate endobronchial brachytherapy.
abstract: To determine risk factors associated with fatal hemoptysis (FH) in endobronchial high dose-rate brachytherapy (EHDRB) 84 patients treated with EHDRB from January 1991 to June 2002 were studied. Clinical and technical parameters (including treatment volumes) were analyzed. Eight (9.5%) patients died of FH, all but one with recurrent or persistent local disease. Median interval until death due to FH was 4 months versus 6 months for the whole group. The only factor with significant correlation with FH was the 100% isodose volume (V100) (p=0.04). Larger irradiated volumes were related to FH. Analysis of volume parameters is suggested, together with the dose and number of fractions prescribed for each patient.
authors.affiliation: Division of Oncology, Radiotherapy, Radiology Institute, Hospital das Clínicas, University of São Paulo Medical School, INRAD Radiotherapy, São Paulo, SP, Brazil. heloisa-carvalho@uol.com.br
authors.forename: Heloisa de Andrade
authors.initials: Hde A
authors.lastname: Carvalho
authors.forename: Silmara Luci Vernúcio
authors.initials: SL
authors.lastname: Gonçalves
authors.forename: Wilson
authors.initials: W
authors.lastname: Pedreira
authors.forename: Marcelo Gervilla
authors.initials: MG
authors.lastname: Gregório
authors.forename: Isac
authors.initials: I
authors.lastname: de Castro
authors.forename: Salim
authors.initials: S
authors.lastname: Aisen
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001918:Brachytherapy / Q000009:adverse effects*; D001984:Bronchial Neoplasms / Q000532:radiotherapy*; D002289:Carcinoma, Non-Small-Cell Lung / Q000532:radiotherapy*; D018288:Carcinoma, Small Cell / Q000532:radiotherapy*; D005260:Female; D006469:Hemoptysis / Q000209:etiology* / Q000401:mortality; D006801:Humans; D008175:Lung Neoplasms / Q000532:radiotherapy*; D008297:Male; D008875:Middle Aged; D012372:ROC Curve; D011879:Radiotherapy Dosage; D012189:Retrospective Studies; D012307:Risk Factors; D016019:Survival Analysis