title: Comparison of dexpanthenol and zinc oxide ointment with ointment base in the treatment of irritant diaper dermatitis from diarrhea: a multicenter study.
abstract: BACKGROUND
  Severity of irritant diaper dermatitis (IDD) from diarrhea varies from patient to patient depending on the nature of feces and the number of bowel movements. The purpose of the present study was to compare the effectiveness of dexpanthenol and zinc oxide ointment with ointment base in the treatment of irritant diaper dermatitis from acute diarrhea in children by measuring transepidermal water loss (TEWL).
  
  
  METHODS
  Forty-six children with diarrhea were prospectively, block randomized, investigator-blinded to receive dexpanthenol and zinc oxide ointment on one side and ointment base on the other side. TEWL was measured before and on days 1, 3, and 7 of treatment together with the assessment of severity score. The efficacy of treatment was defined by complete clearance of the lesion.
  
  
  RESULTS
  TEWL in the treated and control side was not different before the application of the topical medication. In the present study, the efficacy of 5% dexpanthenol and zinc oxide ointment on D3 was 39% (18from 46 patients) compared to 32% in the ointment base side. On D7, the efficacy of the treated side was 58.7% and the ointment base side was 56%. The patients who still had skin lesions were those who had prolonged diarrhea. On the treated side, the mean of TEWL was lower than the control side on DI (p = 0.18) and had significant improvement on D3 (p = 0. 002). At the end of the present study, TEWL on the treated side was less than TEWL of the control side but it did not have statistical significance (p = 0.07). There was no rash or sign of abnormality on the treated side at the end of D7.
  
  
  CONCLUSIONS
  In the treatment of lDD from acute diarrhea, 5% dexpanthenol and zinc oxide ointment significantly decreased TEWL in the treated side more than the ointment base on day 3 but the severity score was not significantly different on days 1, 3 and 7.
authors.affiliation: Department of Pediatrics, Division of Pediatric Dermatology, Faculty of Medicine, Chulalongkorn University, Rama IV Rd, Bangkok 10330, Thailand. siriwanwananukul@yahoo.com
authors.forename: Siriwan
authors.initials: S
authors.lastname: Wananukul
authors.forename: Wanida
authors.initials: W
authors.lastname: Limpongsanuruk
authors.forename: Srisupalak
authors.initials: S
authors.lastname: Singalavanija
authors.forename: Wanee
authors.initials: W
authors.lastname: Wisuthsarewong
mesh_terms: D003879:Dermatologic Agents / Q000627:therapeutic use*; D003963:Diaper Rash / Q000188:drug therapy / Q000209:etiology*; D003967:Diarrhea / Q000150:complications*; D005260:Female; D006801:Humans; D007223:Infant; D007224:Infant Care; D008297:Male; D009823:Ointment Bases / Q000627:therapeutic use*; D010205:Pantothenic Acid / Q000031:analogs & derivatives* / Q000627:therapeutic use; D011446:Prospective Studies; D015034:Zinc Oxide / Q000627:therapeutic use*
chemical_list: D003879:Dermatologic Agents; D009823:Ointment Bases; D010205:Pantothenic Acid; C007288:dexpanthenol; D015034:Zinc Oxide