title: Metachronous, multicentric giant cell tumor of the sphenoid bone with histologic, CT, MR imaging, and positron-emission tomography/CT correlation.
abstract: Giant cell tumor (GCT) of the sphenoid bone is a relatively rare entity and metachronous multicentric GCT of the sphenoid is even rarer; we are aware of only 3 previous cases in the literature. We describe here a tumor of the sphenoid bone that was identified 15 years after multiple resections of a GCT of the left inferior pubic ramus. Correlation is made between the histopathologic findings, MR imaging of the brain, CT of the head, and fusion positron-emission tomography (PET)/CT scan performed with fluorine-18 fluoro-2-deoxy-D-glucose (18F-FDG). This report is the first to describe the appearance of a GCT of the sphenoid bone on a fusion PET/CT examination. High metabolic activity in the base of the skull adjacent to the middle cranial fossa was demonstrated in a fashion similar to that of the known pelvic lesion. This case also demonstrates that the increased metabolic activity seen in a GCT of the sphenoid bone may be partially obscured by the adjacent physiologic high metabolic activity of the brain.
authors.affiliation: Department of Radiology, University of Minnesota Medical School and Hennepin County Medical Center, Minneapolis, MN 55415, USA. mckin022@umn.edu
authors.forename: A M
authors.initials: AM
authors.lastname: McKinney
authors.forename: P
authors.initials: P
authors.lastname: Reichert
authors.forename: J
authors.initials: J
authors.lastname: Short
authors.forename: T
authors.initials: T
authors.lastname: Dhurairaj
authors.forename: K
authors.initials: K
authors.lastname: SantaCruz
authors.forename: Z
authors.initials: Z
authors.lastname: McKinney
authors.forename: S
authors.initials: S
authors.lastname: Kieffer
mesh_terms: D000328:Adult; D005260:Female; D018212:Giant Cell Tumor of Bone / Q000175:diagnosis*; D006801:Humans; D008279:Magnetic Resonance Imaging; D016609:Neoplasms, Second Primary / Q000175:diagnosis*; D049268:Positron-Emission Tomography; D012888:Skull Neoplasms / Q000175:diagnosis*; D013100:Sphenoid Bone; D014057:Tomography, X-Ray Computed