New uses for older antibiotics: nitrofurantoin, amikacin, colistin, polymyxin B, doxycycline, and minocycline revisited.
Nitrofurantoin, amikacin, colistin, polymyxin B, doxycycline, and minocycline are antibiotics with proven effectiveness against selected pathogens. These antibiotics have not developed resistance over time. As "low-resistance potential antibiotics" that are effective against an increasing number of infections due to resistant gram-positive or gram-negative pathogens, these antimicrobials remain an important part of the antibiotic armamentarium. They will be used increasingly in the future, as highly resistant organisms continue to be important clinically and therapeutic options remain limited.
Cunha
Burke A
BA
State University of New York School of Medicine, Stony Brook, NY, USA.
D000583:Amikacin / Q000627:therapeutic use; D002462:Cell Membrane / Q000187:drug effects; D003091:Colistin / Q000627:therapeutic use; D004318:Doxycycline / Q000627:therapeutic use; D004352:Drug Resistance, Microbial; D016905:Gram-Negative Bacterial Infections / Q000188:drug therapy; D006801:Humans; D016106:Methicillin Resistance; D008911:Minocycline / Q000627:therapeutic use; D009582:Nitrofurantoin / Q000627:therapeutic use*; D011112:Polymyxin B / Q000627:therapeutic use; D013203:Staphylococcal Infections / Q000188:drug therapy; D014552:Urinary Tract Infections / Q000188:drug therapy
D000583:Amikacin; D009582:Nitrofurantoin; D008911:Minocycline; D011112:Polymyxin B; D004318:Doxycycline; D003091:Colistin