title: Using HapMap data: a cautionary note.
abstract: The HapMap data are being widely used in human genetic studies. We show by direct resequencing of a approximately 6-kb region of chromosome 1 that the HapMap data are unreliable for this region. This region contains a recent mitochondrial (mt) DNA insertion. The HapMap data report the corresponding mtDNA variation and not the nuclear DNA variation. In view of mtDNA insertions of varying lengths throughout the human genome and considerable segmental duplications, it is necessary to use the HapMap data cautiously.
authors.affiliation: Human Genetics Unit, Indian Statistical Institute, Kolkata, West Bengal, India.
authors.forename: Nidhan K
authors.initials: NK
authors.lastname: Biswas
authors.forename: Badal
authors.initials: B
authors.lastname: Dey
authors.forename: Partha P
authors.initials: PP
authors.lastname: Majumder
mesh_terms: D002878:Chromosomes, Human, Pair 1 / Q000235:genetics*; D004272:DNA, Mitochondrial / Q000235:genetics; D030541:Databases, Genetic / Q000592:standards*; D015894:Genome, Human / Q000235:genetics*; D006801:Humans; D011110:Polymorphism, Genetic; D017422:Sequence Analysis, DNA
chemical_list: D004272:DNA, Mitochondrial