Sesquiterpenes from Thapsia nitida var. meridionalis and Thapsia nitida var. nitida.
Nine new eudesmanolides (1-9), two new guaianolides (12 and 13), and a new germacrane (10), along with a previously reported guaianolide (11), have been isolated from the roots of Thapsia nitida var. meridionalis. Thapsia nitida var. nitida also afforded compound 13 along with a new guaianolide (14). The structure of 13 was confirmed by X-ray crystallographic analysis. Compounds 1, 2, and 11-14 have been tested as potential inhibitors of the sarco- and endoplasmic Ca2+-dependent ATPases (SERCA) pump. None of them showed significant activities.
Rubal
Juan J
JJ
Departamento de Química Orgánica, Facultad de Ciencias, Universidad de Cádiz, Apartado 40, 11510 Puerto Real, Cádiz, Spain.
Guerra
Francisco M
FM
Moreno-Dorado
F Javier
FJ
Jorge
Zacarías D
ZD
Massanet
Guillermo M
GM
Søhoel
Helmer
H
Smitt
Ulla W
UW
Frydenvang
Karla
K
Christensen
S Brøgger
SB
Nielsen
Charlotte
C
Eriksson
Margit
M
D018360:Crystallography, X-Ray; D008968:Molecular Conformation; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D053498:Sarcoplasmic Reticulum Calcium-Transporting ATPases / Q000037:antagonists & inhibitors*; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013030:Spain; D053629:Thapsia / Q000737:chemistry*
D012717:Sesquiterpenes; D053498:Sarcoplasmic Reticulum Calcium-Transporting ATPases