Antibiotic therapy for Helicobacter pylori.
Helicobacter pylori is one of the most common bacterial infections in the world. H pylori infection of the gastric mucosa is the most common cause of peptic ulcers and is believed to be responsible for 50% to 60% of all gastric carcinomas. This infection is difficult to treat because the bacterium is located within the gastric lumen in the mucus and not within the gastric tissue. Antimicrobial therapy for H pylori includes two or three antibiotics plus either a proton pump inhibitor or a histamine receptor antagonist. H pylori readily develops resistance to antibiotics; therefore, if the initial treatment is unsuccessful, repeat treatment should include different antibiotics.
Collins
Jason
J
Gastroenterology Section, Department of Medicine, Howard University College of Medicine, Washington, DC 20059, USA.
Ali-Ibrahim
Amira
A
Smoot
Duane T
DT
D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D004381:Duodenal Ulcer / Q000188:drug therapy; D016481:Helicobacter Infections / Q000175:diagnosis / Q000188:drug therapy*; D016480:Helicobacter pylori / Q000187:drug effects*; D006801:Humans; D010406:Penicillins / Q000276:immunology; D010437:Peptic Ulcer / Q000188:drug therapy
D000900:Anti-Bacterial Agents; D010406:Penicillins