Does edaravone (MCI- 186) act as an antioxidant and a neuroprotector in experimental traumatic brain injury?
Edaravone (MCI-186) is a novel synthetic free radical scavenger intended to have neuroprotective effect against ischemic insult. It is currently used on patients with cerebral infarction. Here, we note beneficial pharmaceutical effects of edaravone in rat experimental traumatic brain injury. Under specific experimental conditions, edaravone minimized traumatic brain injury by functioning as a synthetic antioxidant. Clinical trials testing the efficacy of edaravone are warranted.
Dohi
Kenji
K
Showa University, Department of Emergency and Critical Care Medicine, Tokyo, Japan. kdop@med.showa-u.ac.jp
Satoh
Kazue
K
Nakamachi
Tomoya
T
Yofu
Sachiko
S
Hiratsuka
Keisuke
K
Nakamura
Shunsuke
S
Ohtaki
Hirokazu
H
Yoshikawa
Toshikazu
T
Shioda
Seiji
S
Aruga
Tohru
T
D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D000983:Antipyrine / Q000031:analogs & derivatives* / Q000494:pharmacology; D001769:Blood / Q000378:metabolism; D001930:Brain Injuries / Q000188:drug therapy*; D000077553:Edaravone; D016166:Free Radical Scavengers / Q000494:pharmacology; D006801:Humans; D015227:Lipid Peroxidation; D009474:Neurons / Q000473:pathology; D018696:Neuroprotective Agents / Q000494:pharmacology; D009569:Nitric Oxide / Q000737:chemistry; D051381:Rats; D017382:Reactive Oxygen Species; D013997:Time Factors; D024502:alpha-Tocopherol / Q000737:chemistry
D000975:Antioxidants; D016166:Free Radical Scavengers; D018696:Neuroprotective Agents; D017382:Reactive Oxygen Species; D009569:Nitric Oxide; D024502:alpha-Tocopherol; D000077553:Edaravone; D000983:Antipyrine