title: Two cases of human granulocytic ehrlichiosis in Sardinia, Italy confirmed by PCR.
abstract: In this work we report the first two cases of human granulocytic ehrlichiosis (HGE) in Sardinia. In early September 2004, a 69-year-old woman (patient 1) was admitted to the Infectious Diseases Institute of Sassari for rickettsiosis like-syndrome: high fever (39.5-40 degrees C), dyspnea, reduced consciousness, vomiting, and cutaneous rash. In late September 2004, a 30-year-old man (patient 2) with high fever was admitted for an evident palmar and oral erythema, edema of the labium, very intense arthralgia, myalgia, and dyspnea. In these two hospitalized patients, the diagnosis was made through indirect IgM and IgG immunofluorescent technique and confirmed by the presence of the specific DNA in the leukocytes. The two patients were A. phagocytophilum-PCR positive.
authors.affiliation: Istituto Zooprofilattico Sperimentale della Sardegna, Via Duca degli Abruzzi 8, 07100 Sassari, Sardinia, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Mastrandrea
authors.forename: M S
authors.initials: MS
authors.lastname: Mura
authors.forename: S
authors.initials: S
authors.lastname: Tola
authors.forename: C
authors.initials: C
authors.lastname: Patta
authors.forename: A
authors.initials: A
authors.lastname: Tanda
authors.forename: R
authors.initials: R
authors.lastname: Porcu
authors.forename: G
authors.initials: G
authors.lastname: Masala
mesh_terms: D000328:Adult; D000368:Aged; D000907:Antibodies, Bacterial / Q000097:blood; D016873:Ehrlichiosis / Q000175:diagnosis* / Q000276:immunology; D004890:Erythema / Q000382:microbiology; D005260:Female; D019084:Fluorescent Antibody Technique, Indirect; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D007558:Italy; D008297:Male
chemical_list: D000907:Antibodies, Bacterial; D007074:Immunoglobulin G; D007075:Immunoglobulin M