title: Increased farnesylation of p21-Ras and neonatal macrosomia in women with gestational diabetes.
abstract: Six of 22 mothers with gestational diabetes mellitus had infants with macrosomia, cord blood hyperinsulinemia, and increased amounts of a key mitogenic intermediate, farnesylated p21-Ras. The ability of fetal hyperinsulinemia to increase the availability of farnesylated p21-Ras may represent one mechanism of the growth-promoting action of insulin during fetal development.
authors.affiliation: Department of Pediatrics, Medicine of the University of Colorado Health Sciences Center, Research Service of the Denver Veterans Affairs Medical Center, Colorado, USA. thureen@uchsc.edu
authors.forename: Patti
authors.initials: P
authors.lastname: Thureen
authors.forename: Melanie
authors.initials: M
authors.lastname: Reece
authors.forename: Donna
authors.initials: D
authors.lastname: Rodden
authors.forename: Lynn
authors.initials: L
authors.lastname: Barbour
authors.forename: James
authors.initials: J
authors.lastname: Chappell
authors.forename: J Wayne
authors.initials: JW
authors.lastname: Leitner
authors.forename: Richard O
authors.initials: RO
authors.lastname: Jones
authors.forename: Boris
authors.initials: B
authors.lastname: Draznin
mesh_terms: D016640:Diabetes, Gestational / Q000378:metabolism*; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D005320:Fetal Macrosomia / Q000097:blood* / Q000378:metabolism; D006801:Humans; D007231:Infant, Newborn; D007328:Insulin / Q000097:blood*; D007962:Leukocytes / Q000737:chemistry*; D011247:Pregnancy; D017368:Protein Prenylation; D016283:Proto-Oncogene Proteins p21(ras) / Q000378:metabolism*
chemical_list: D007328:Insulin; D016283:Proto-Oncogene Proteins p21(ras)