A novel one-pot reaction involving organocopper-mediated reduction/transmetalation/asymmetric alkylation, leading to the diastereoselective synthesis of functionalized (Z)-fluoroalkene dipeptide isosteres.
By a novel one-pot reaction sequence involving consecutive organocopper-mediated reduction, transmetalation and asymmetric alkylation, a highly diastereoselective synthesis of functionalized (Z)-fluoroalkene dipeptide isosteres was achieved in good to excellent yields.
Narumi
Tetsuo
T
Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, Japan.
Niida
Ayumu
A
Tomita
Kenji
K
Oishi
Shinya
S
Otaka
Akira
A
Ohno
Hiroaki
H
Fujii
Nobutaka
N
D000475:Alkenes / Q000737:chemistry*; D000478:Alkylation; D003300:Copper / Q000737:chemistry*; D004151:Dipeptides / Q000737:chemistry*; D005461:Fluorine / Q000737:chemistry*; D015394:Molecular Structure; D010084:Oxidation-Reduction; D013237:Stereoisomerism
D000475:Alkenes; D004151:Dipeptides; D005461:Fluorine; D003300:Copper