title: Clinical databases in nephrology: research and clinical practice goals and challenges.
abstract: In clinical practice we formulate direct questions related to patient management that should be answered on the basis of results of valid studies. Bias problems are dealt with using different approaches in observational studies and in clinical trials. The clinical trial is the standard for assessing the efficacy of treatments while the efficiency of treatments at community level is better captured by observational studies. Electronic medical records have now emerged as a precious, matchless data source for clinical audits. The value of an audit cannot be taken for granted and should be tested in the specific health care setting where it is applied. Electronic medical records and high quality clinical databases offer a great opportunity for performing observational studies and for reducing the cost of clinical trials. Research on audit and feedback functionality is a new, useful and stimulating research area which may be of great interest to nephrologists.
authors.affiliation: Unit of Nephrology, Dialysis and Renal Transplant, CNR-IBIM, Institute of Biomedicine, Clinical Epidemiology and Physiopathology of Renal Diseases and Hypertension, Ospedali Riuniti Reggio Calabria-Italy. carmine.zoccali@tin.it
authors.forename: Carmine
authors.initials: C
authors.lastname: Zoccali
mesh_terms: D054869:Clinical Audit / Q000592:standards / Q000639:trends; D002986:Clinical Trials as Topic / Q000592:standards / Q000639:trends; D016208:Databases, Factual / Q000592:standards / Q000639:trends; D007674:Kidney Diseases; D016347:Medical Records Systems, Computerized / Q000592:standards / Q000639:trends; D009398:Nephrology / Q000379:methods / Q000592:standards / Q000639:trends