title: MHC class II genes in Mexican patients with idiopathic dilated cardiomyopathy.
abstract: The purpose of the present study was to evaluate the relationship between class II major histocompatibility complex (MHC) genes (HLA-DR and HLA-DQB) and the genetic susceptibility to idiopathic dilated cardiomyopathy (IDC) in Mexican patients. The HLA-DR and DQB alleles were analyzed in 53 patients with IDC and 99 ethnically matched healthy controls using the polymerase chain reaction-sequence specific oligonucleotides (PCR-SSO) technique. IDC patients showed increased frequencies of HLA-DR4 (pC=0.02, OR=1.87), HLA-DQB1*0301 (pC=0.02, OR=1.92) and HLA-DQB1*0302 (pC=0.02, OR=1.87) when compared to healthy controls. On the other hand, IDC patients also showed decreased frequencies of HLA-DR11 allele (pC=0.03, OR=0.26) and HLA-DQB1*0201 (pC=0.04, OR=0.41). These data suggest that variation in class II HLA alleles could be a genetic factor involved in the susceptibility to IDC of the Mexican Mestizo population.
authors.affiliation: Department of Physiology, Cardiovascular Disease's Genomic and Proteomic Study Group, Instituto Nacional de Cardiología Ignacio Chávez, Tlalpan 14080, Mexico City, Mexico.
authors.forename: José Manuel
authors.initials: JM
authors.lastname: Rodríguez-Pérez
authors.forename: José Manuel
authors.initials: JM
authors.lastname: Fragoso
authors.forename: Edith
authors.initials: E
authors.lastname: Alvarez-León
authors.forename: Nancy
authors.initials: N
authors.lastname: Martínez-Rodríguez
authors.forename: Guillermo J
authors.initials: GJ
authors.lastname: Gallardo
authors.forename: Selene
authors.initials: S
authors.lastname: Inés-Real
authors.forename: Julio
authors.initials: J
authors.lastname: Granados
authors.forename: Pedro A
authors.initials: PA
authors.lastname: Reyes
authors.forename: Gilberto
authors.initials: G
authors.lastname: Vargas-Alarcón
mesh_terms: D002311:Cardiomyopathy, Dilated / Q000235:genetics*; D005802:Genes, MHC Class II; D020022:Genetic Predisposition to Disease; D006801:Humans; D008800:Mexico; D016133:Polymerase Chain Reaction