Antibiotic drug interactions.
Drug-drug interactions in the field of infectious diseases continue to expand as new drugs are approved, metabolic enzymes and transporters are identified, and recommendations for co-administration of drugs are revised. This article provides an overview of the principles and mechanisms of drug-drug interactions and describes pharmacokinetic-pharmacodynamic interactions commonly associated with antibacterial therapy, antiviral agents (non-retroviral), and drugs for tuberculosis.
Pai
Manjunath P
MP
University of New Mexico, College of Pharmacy, MSC09 5360, Albuquerque, NM 87131, USA.
Momary
Kathryn M
KM
Rodvold
Keith A
KA
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000037:antagonists & inhibitors; D000617:Aminoglycosides / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D000995:Antitubercular Agents / Q000627:therapeutic use; D000998:Antiviral Agents / Q000627:therapeutic use; D002701:Chloramphenicol / Q000627:therapeutic use; D002939:Ciprofloxacin / Q000627:therapeutic use; D065607:Cytochrome P-450 Enzyme Inhibitors; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004347:Drug Interactions; D024841:Fluoroquinolones / Q000627:therapeutic use; D041981:Gastrointestinal Tract / Q000187:drug effects / Q000382:microbiology; D006635:Histamine H2 Antagonists / Q000627:therapeutic use; D006801:Humans; D009980:Influenza A virus / Q000187:drug effects; D018942:Macrolides / Q000627:therapeutic use; D010599:Pharmacokinetics; D013754:Tetracyclines / Q000627:therapeutic use; D047090:beta-Lactams / Q000627:therapeutic use
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D000995:Antitubercular Agents; D000998:Antiviral Agents; D065607:Cytochrome P-450 Enzyme Inhibitors; D024841:Fluoroquinolones; D006635:Histamine H2 Antagonists; D018942:Macrolides; D013754:Tetracyclines; D047090:beta-Lactams; D002939:Ciprofloxacin; D002701:Chloramphenicol; D003577:Cytochrome P-450 Enzyme System