Intravascular large B-cell lymphoma associated with a near-tetraploid karyotype, rearrangement of BCL6, and a t(11;14)(q13;q32).
Chromosome analysis of a patient with intravascular large B-cell lymphoma (IVL) revealed a complex, near-tetraploid karyotype with 83 chromosomes. Abnormalities included a t(11;14)(q13;q32), which was confirmed with both interphase fluorescence in situ hybridization (FISH) using an IGH/cyclin D1 dual-color, dual-fusion probe set and cyclin D1 immunohistochemical analysis. Abnormality of 3q was also evident. Interphase FISH analysis with a dual-color, break-apart probe set confirmed rearrangement of BCL6. To our knowledge, this is the first report of these abnormalities in IVL.
Rashid
Rumana
R
HMDS Laboratory, Leeds Teaching Hospitals NHS Trust, Great George Street, Leeds, UK. rumana@doctors.org.uk
Johnson
Roderick J
RJ
Morris
Stephen
S
Dickinson
Helen
H
Czyz
Jarek
J
O'Connor
Sheila J M
SJ
Owen
Roger G
RG
D002880:Chromosomes, Human, Pair 11; D002883:Chromosomes, Human, Pair 14; D004268:DNA-Binding Proteins / Q000235:genetics*; D005260:Female; D006801:Humans; D007621:Karyotyping; D016393:Lymphoma, B-Cell / Q000235:genetics* / Q000473:pathology; D016403:Lymphoma, Large B-Cell, Diffuse / Q000235:genetics* / Q000473:pathology; D008875:Middle Aged; D011123:Polyploidy; D051560:Proto-Oncogene Proteins c-bcl-6; D014178:Translocation, Genetic; D014407:Tumor Cells, Cultured; D019043:Vascular Neoplasms / Q000235:genetics* / Q000473:pathology
C084103:BCL6 protein, human; D004268:DNA-Binding Proteins; D051560:Proto-Oncogene Proteins c-bcl-6