title: [The PAI-1 swing: microenvironment and cancer cell migration].
abstract: Cancer is a complex and dynamic process caused by a cellular dysfunction leading to a whole organ or even organism vital perturbation. To better understand this process, we need to study each one of the levels involved, which allows the scale change, and to integrate this knowledge. A matricellular protein, PAI-1, is able to induce in vitro cell behaviour modifications, morphological changes, and to promote cell migration. PAI-1 influences the mesenchymo-amaeboid transition. This matricellular protein should be considered as a potential 'launcher' of the metastatic process acting at the molecular, cellular, tissular levels and, as a consequence, at the organism's level.
authors.affiliation: Equipe DYNAMIC, Dynamique du Microenvironnement Cellulaire, Informatique, Biologie Intégrative et Systèmes Complexes), FRE 2873 CNRS, Université d'Evry-Val d'Essonne, Université Paris 12, Génopole, France.
authors.forename: Michel
authors.initials: M
authors.lastname: Malo
authors.forename: Cécile
authors.initials: C
authors.lastname: Charrière-Bertrand
authors.forename: Chafika
authors.initials: C
authors.lastname: Chettaoui
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Fabre-Guillevin
authors.forename: François
authors.initials: F
authors.lastname: Maquerlot
authors.forename: Alexandra
authors.initials: A
authors.lastname: Lackmy
authors.forename: Benoît
authors.initials: B
authors.lastname: Vallée
authors.forename: Franck
authors.initials: F
authors.lastname: Delaplace
authors.forename: Georgia
authors.initials: G
authors.lastname: Barlovatz-Meimon
mesh_terms: D002448:Cell Adhesion / Q000502:physiology*; D002465:Cell Movement / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D009369:Neoplasms / Q000235:genetics / Q000473:pathology / Q000503:physiopathology*; D017395:Plasminogen Activator Inhibitor 1 / Q000502:physiology*; D012333:RNA, Messenger / Q000235:genetics
chemical_list: D017395:Plasminogen Activator Inhibitor 1; D012333:RNA, Messenger