title: [Results the application of mitomicyn during endonasal and endocanalicular dacryocystorhinostomy by diode laser].
abstract: OBJECTIVE
  To study the effects, secondary effects and security of the intrasurgical application of mitomicyn C during endonasal and endocanalicular dacryocystorhinostomy with diode laser (TLA-ELA DCR).
  
  
  METHODS
  We carried out a randomized, prospective, interventional and double blind study in 200 patients: intrasurgical mitomicyn C was applied in 150 of then (0.4 mgr/0.2 ml) for 5 minutes by means of a polivinil acetate dressing over the osteotomy. In other 50 patients MMC was not used we followed up at 24 hours, 10 days and 1, 3 and 6 months after surgery. Endoscopic aspects and possible complications were valued. The results were compared using the Chi-squared test with the Yates correction. We looked for the presence or abscense of secondary effects in the application of mitomicyn C.
  
  
  RESULTS
  The average follow up was 15.25 months (range 6 to 21 months). The percentages of alterations for excesive scarring were 21.77% in patients without and MAC 8.03% in the ones MMC. The difference was statisticaly significant (p = 0.02). We did not find secondary effects due to application of mitomcyn.
  
  
  CONCLUSIONS
  Intrasurgical application of topical MMC during TLA-ENL DCR reduces the number of pathological findings due to scarring of the surrouding area of the new drainage without secondary effects.
authors.affiliation: Instituto Internacional de Vías Nasolagrimales, Jaén. miguelaaf@msn.com
authors.forename: M A
authors.initials: MA
authors.lastname: Alañón Fernandez
authors.forename: F J
authors.initials: FJ
authors.lastname: Alañón Fernandez
authors.forename: A
authors.initials: A
authors.lastname: Martínez Fernández
authors.forename: M
authors.initials: M
authors.lastname: Cárdenas Lara
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002921:Cicatrix / Q000209:etiology / Q000517:prevention & control*; D003608:Dacryocystorhinostomy / Q000009:adverse effects / Q000379:methods*; D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D053685:Laser Therapy; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000627:therapeutic use*; D019384:Nucleic Acid Synthesis Inhibitors / Q000627:therapeutic use*; D011446:Prospective Studies
chemical_list: D019384:Nucleic Acid Synthesis Inhibitors; D016685:Mitomycin