title: Donor-type myelodysplastic syndrome with t(2;3) and monosomy 7 after allogeneic peripheral blood stem cell transplantation and liver transplantation in a patient with severe-type aplastic anemia.
abstract: Secondary clonal hemaloiogical disease in donor cells has rarely been reported as a complication of allogeneic stem cell transplantation in hematological disease. We report a case of myelodysplastic syndrome that showed cytogenetic abnormalities of t(2;3) and monosomy 7, which developed 2 years after peripheral blood stem cell transplantation for aplastic anemia and 1 year after liver transplantation for drug-induced hepatic failure. This secondary malignancy of donor origin is most frequently seen in patients with leukemia. We suspect that the chromosomal abnormalities are related to hepatitis-associated aplastic anemia, administration of granulocyte colony-stimulating factor and erythropoietin for posttransplantion pancytopenia, and repeated infections after liver transplantation.
authors.affiliation: Department of Gastroenterology and Hematology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Hashino
authors.forename: Fumie
authors.initials: F
authors.lastname: Fujisawa
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kondo
authors.forename: Masahiro
authors.initials: M
authors.lastname: Imamura
authors.forename: Kazuya
authors.initials: K
authors.lastname: Sato
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Torimoto
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Kohgo
authors.forename: Keisuke
authors.initials: K
authors.lastname: Kimura
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Furukawa
authors.forename: Satoru
authors.initials: S
authors.lastname: Todo
authors.forename: Masahiro
authors.initials: M
authors.lastname: Asaka
mesh_terms: D000328:Adult; D000741:Anemia, Aplastic / Q000150:complications* / Q000628:therapy*; D001782:Blood Donors; D002889:Chromosomes, Human, Pair 2; D002893:Chromosomes, Human, Pair 3; D002897:Chromosomes, Human, Pair 7; D005260:Female; D006801:Humans; D016031:Liver Transplantation / Q000009:adverse effects*; D009006:Monosomy; D009190:Myelodysplastic Syndromes / Q000209:etiology* / Q000235:genetics*; D036102:Peripheral Blood Stem Cell Transplantation / Q000009:adverse effects*; D014178:Translocation, Genetic; D014184:Transplantation, Homologous