Synthesis and characterization of xylan-coated magnetite microparticles.
This work evaluates an experimental set-up to coat superparamagnetic particles in order to protect them from gastric dissolution. First, magnetic particles were produced by coprecipitation of iron salts in alkaline medium. Afterwards, an emulsification/cross-linking reaction was carried out in order to produce magnetic polymeric particles. The sample characterization was performed by X-ray powder diffraction, laser scattering particle size analysis, optical microscopy, thermogravimetric analysis and vibrating sample magnetometry. In vitro dissolution tests at gastric pH were evaluated for both magnetic particles and magnetic polymeric particles. The characterization data have demonstrated the feasibility of the presented method to coat, and protect magnetite particles from gastric dissolution. Such systems may be very promising for oral administration.
Silva
Amanda K Andriola
AK
Programa de Pós-Graduação em Ciências da Saúde, Universidade Federal do Rio Grande do Norte, Rua Gal. Gustavo C. de Farias s/n, Natal/RN 59010-180, Brazil.
da Silva
Erica L
EL
Oliveira
Elquio E
EE
Nagashima
T
T
Soares
Luiz Alberto L
LA
Medeiros
Aldo C
AC
Araújo
José H
JH
Araújo
Ivonete B
IB
Carriço
Artur S
AS
Egito
E Sócrates T
ES
D000284:Administration, Oral; D003692:Delayed-Action Preparations; D016503:Drug Delivery Systems; D052203:Ferrosoferric Oxide / Q000138:chemical synthesis / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D007834:Lasers; D008280:Magnetics; D008855:Microscopy, Electron, Scanning; D010316:Particle Size; D011108:Polymers / Q000737:chemistry*; D012542:Scattering, Radiation; D012995:Solubility; D013818:Thermogravimetry; D014961:X-Ray Diffraction; D014990:Xylans / Q000737:chemistry*; D003313:Zea mays
D003692:Delayed-Action Preparations; D011108:Polymers; D014990:Xylans; D052203:Ferrosoferric Oxide