The GCK II and III subfamilies of the STE20 group kinases.
The Ste20 (sterile 20) proteins are a large family of serine/threonine kinases. Since their discovery a growing body of evidence has implicated them in the regulation of signaling pathways governing cell growth, cell differentiation cell death and cell volume. Approximately 30 human members have been identified based on the high degree of homology of their catalytic domain to that of the Ste20p from Saccharomyces cerevisiae. In addition to the conserved regions, there are also regions of sequence that make each of them unique. In this review we will focus on two subfamilies of the group, GCK-II and GCK-III, families that are closely related but, again, unique in their structural features and biological functions. Herein, we will present what we hope will be the current state of knowledge about these kinases, and discuss what remains to be done in order to better understand their activity and regulation.
Pombo
Celia María
CM
Department of Physiology,Scholl of Medicine, University of Santiago de Compostela, A Coruña, Spain. fspombo@usc.es
Force
Thomas
T
Kyriakis
John
J
Nogueira
Emilio
E
Fidalgo
Miguel
M
Zalvide
Juan
J
D000818:Animals; D020134:Catalytic Domain; D004789:Enzyme Activation; D006801:Humans; D023421:Models, Animal; D017346:Protein Serine-Threonine Kinases / Q000737:chemistry / Q000145:classification / Q000502:physiology*; D015398:Signal Transduction
D017346:Protein Serine-Threonine Kinases