On the role of specific chaperones, the specific ATPase, and the proton motive force in type III secretion.
Type III secretion systems (T3SSs) are engaged by a broad number of Gram-negative bacteria to inject proteins into host cells. The simultaneous crossing of three biological membranes by these proteins is a phenomenon which is far from being understood mechanistically. However, recent work from several groups has substantially enriched our conception of how proteins travel from the bacterial into the host cell cytosol. Here, we focus on the role of specific T3SS chaperones, the specific ATPase, and the proton motive force in type III secretion.
Wilharm
Gottfried
G
Max von Pettenkofer-Institut, Lehrstuhl für Bakteriologie, Ludwig-Maximilians-Universität München, Pettenkoferstrasse 9a, D-80336 Munich, Germany. wilharm@mvp.uni-muenchen.de
Dittmann
Svea
S
Schmid
Annika
A
Heesemann
Jürgen
J
D000251:Adenosine Triphosphatases / Q000378:metabolism*; D001426:Bacterial Proteins / Q000378:metabolism*; D006090:Gram-Negative Bacteria / Q000378:metabolism*; D018832:Molecular Chaperones / Q000502:physiology*; D021381:Protein Transport; D018892:Proton-Motive Force; D037521:Virulence Factors / Q000378:metabolism*
D001426:Bacterial Proteins; D018832:Molecular Chaperones; D037521:Virulence Factors; D000251:Adenosine Triphosphatases