Decreased desychronisation during self-paced movements in frequency bands involving sensorimotor integration and motor functioning in Parkinson's disease.
This study examined sensorimotor integration and motor functioning in seven patients with Parkinson's disease (PD) who had mild symptoms, and seven age-matched controls. Neuro-oscillations were recorded by high-density 128-channel electroencephalography (EEG). Participants were required to perform two tasks: simple tapping of the index finger and thumb and a complex Luria finger apposition task. Both tasks were performed unimanually and bimanually. There were no significant group differences in the task-related power (TRPow) within alpha 1 (mu1) or in beta 1 frequencies (beta1). In contrast, there were significant group differences in the alpha 2 (mu2) and beta 2 frequencies (beta2). Patients had less desychronisation than controls at the electrodes covering the central regions of the scalp. Alpha 2 and beta 2 frequencies have been associated with task-specific sensorimotor integration and motor function, respectively. This activity difference in patients with Parkinson's disease may be due to deficits in sensorimotor integration.
Lim
Vanessa K
VK
Department of Psychology, Research Centre for Cognitive Neuroscience, The University of Auckland, Private Bag 92019, Auckland, New Zealand. v.lim@auckland.ac.nz
Hamm
Jeff P
JP
Byblow
Winston D
WD
Kirk
Ian J
IJ
D000368:Aged; D000369:Aged, 80 and over; D001683:Biological Clocks / Q000502:physiology; D001921:Brain / Q000503:physiopathology*; D001931:Brain Mapping; D004569:Electroencephalography; D005071:Evoked Potentials / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009068:Movement / Q000502:physiology*; D009483:Neuropsychological Tests; D010300:Parkinson Disease / Q000503:physiopathology*; D011597:Psychomotor Performance / Q000502:physiology; D012677:Sensation / Q000502:physiology