Gene activation by bioactive glasses.
Bioactive glasses have been shown to regulate gene expression in both hard and soft tissue repair. New resorbable bioactive glass constructs are now being developed that can influence gene expression in the local environment by manipulating material properties such as the surface chemistry, topography and the release of dissolution ions. The success of these scaffolds, however, may depend upon a greater understanding of the bioactive glass stimulated gene expression pathways. This will allow the construction of tissue specific scaffolds with tailored surface chemistry, topography and ion release rates. This paper summarises the advances made in understanding gene expression in response to bioactive glasses and discusses the future steps required for further insights into these molecular mechanisms.
Jell
G
G
Department of Materials, Imperial College London, Exhibition Road, London, SW7 2AZ, UK.
Stevens
M M
MM
D000818:Animals; D001672:Biocompatible Materials / Q000494:pharmacology*; D002460:Cell Line; D002516:Ceramics / Q000494:pharmacology*; D005786:Gene Expression Regulation / Q000187:drug effects*; D005898:Glass; D006801:Humans; D015533:Transcriptional Activation
D001672:Biocompatible Materials; C425330:bioactive glass 45S5