title: [Association between genetic polymorphism in xeroderma pigmentosum G gene and risks of laryngeal and hypopharyngeal carcinomas].
abstract: OBJECTIVE
  To study the association between polymorphism of DNA repair gene xeroderma pigmentosum G (XPG) Asp1104His and the risks of developing laryngeal and hypopharyngeal carcinomas.
  
  
  METHODS
  Totally 175 patients with laryngeal or hypopharyngeal carcinoma and 525 cancer-free controls were genotyped for the polymorphism by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The odds ratio (OR) and 95% confidence interval (CI) were calculated using unconditional logistic regression model.
  
  
  RESULTS
  Compared with those having the Asp/Asp genotype, patients having the XPG 1104Asp/His genotype had a higher risk for laryngeal carcinoma (OR = 2.46, 95% CI = 1.15-5.24, P < 0.05), but not for hypopharyngeal carcinoma (OR = 1.36, 95% CI = 0.87-2.12, P > 0.05). In addition, the XPG 1104Asp/His genotype appeared to be associated with well differentiated squamous cell carcinoma in both larynx and hypopharynx (OR = 1.88, 95% CI = 1.05-3.40, P < 0.05 ).
  
  
  CONCLUSIONS
  The XPG Asp1104His polymorphism may play a role in the development of laryngeal and hypopharyngeal carcinomas.
authors.affiliation: Department of Head and Neck Surgery, Cancer Hospital, CAMS and PUMC, Beijing 100021, China.
authors.forename: Shu-xin
authors.initials: SX
authors.lastname: Wen
authors.forename: Ping-zhang
authors.initials: PZ
authors.lastname: Tang
authors.forename: Xue-mei
authors.initials: XM
authors.lastname: Zhang
authors.forename: Dan
authors.initials: D
authors.lastname: Zhao
authors.forename: Yong-li
authors.initials: YL
authors.lastname: Guo
authors.forename: Wen
authors.initials: W
authors.lastname: Tan
authors.forename: Dong-xin
authors.initials: DX
authors.lastname: Lin
mesh_terms: D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007012:Hypopharyngeal Neoplasms / Q000235:genetics* / Q000473:pathology; D007822:Laryngeal Neoplasms / Q000235:genetics* / Q000473:pathology; D008297:Male; D011110:Polymorphism, Genetic; D051759:Xeroderma Pigmentosum Group D Protein / Q000235:genetics*
chemical_list: D051759:Xeroderma Pigmentosum Group D Protein