title: Statistical mapping of effects of middle cerebral artery occlusion (MCAO) on blood flow and oxygen consumption in porcine brain.
abstract: The volume of cerebral tissue perturbed in experimental models of middle cerebral artery occlusion (MCAO) can be highly variable. Thus, the territories of reduced cerebral blood flow (CBF) or oxygen consumption (CMRO(2)) following MCAO might properly be defined using statistical parametric mapping within a population. In order to establish such a method, we mapped CBF and CMRO(2) in 18 pigs with acute MCAO. Parametric maps were flipped about the axis of symmetry, and CBF and CMRO(2) in the infarcted hemisphere were calculated as percentages of the magnitudes in mirror-image pixels. There were log-linear relationships between the volumes of affected tissue and the percentages of normal CFB or CMRO(2). This graphical analysis showed that the volume of the core deficit was smaller for CBF that for CMRO(2), but expanded more rapidly with decreasing CBF deficit than did the corresponding volumes of reduced CMRO(2). Thus, acute changes in CBF and CMRO(2) following MCAO in the pig can be defined as probabilistic volumes.
authors.affiliation: PET Center, Aarhus University Hospitals, Aarhus, Denmark.
authors.forename: Hideaki
authors.initials: H
authors.lastname: Watanabe
authors.forename: Masaharu
authors.initials: M
authors.lastname: Sakoh
authors.forename: Flemming
authors.initials: F
authors.lastname: Andersen
authors.forename: Anders
authors.initials: A
authors.lastname: Rodell
authors.forename: Jens Christian
authors.initials: JC
authors.lastname: Sørensen
authors.forename: Leif
authors.initials: L
authors.lastname: Østergaard
authors.forename: Kim
authors.initials: K
authors.lastname: Mouridsen
authors.forename: Paul
authors.initials: P
authors.lastname: Cumming
mesh_terms: D000818:Animals; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology; D001931:Brain Mapping; D002560:Cerebrovascular Circulation / Q000502:physiology*; D005260:Female; D007839:Functional Laterality; D020244:Infarction, Middle Cerebral Artery / Q000000981:diagnostic imaging / Q000473:pathology* / Q000503:physiopathology*; D010101:Oxygen Consumption / Q000502:physiology*; D049268:Positron-Emission Tomography / Q000379:methods; D013552:Swine