title: Sustained and selective attention deficits as vulnerability markers to psychosis.
abstract: The first descriptions of schizophrenia emphasized attention problems patients with schizophrenia have but recent results evidence that other psychotic disorders share them. We compared the performance in sustained and selective attention between psychotic patients (P), their healthy first degree relatives (R) and healthy volunteers (C) to prove whether these alterations could be an endophenotype of vulnerability to psychosis. We also compared the performance of schizophrenic patients (SZP) and that of patients with other functional psychoses (OP) in order to prove whether these alterations are specific of any psychotic disorder. Seventy-six P, 70 R and 39 C were included in the study. A selective attention index, comprising TMT A and B and Stroop Test, and a sustained attention index comprising the Continuous Performance Test were calculated. We conducted an univariant general linear model to compare three group performances in these indexes, with age, sex and years of education as a covariables. We found significant differences between the indexes when we compared P, R and C. No differences in performance were found between SZP and OP. Our data showed that sustained and selective attention alterations could be a vulnerability factor to psychotic disorders in general, but they were not specific of schizophrenia.
authors.affiliation: Departament de Formació i Investigació, Hospital Psiquiàtric Universitari Institut Pere Mata, Ctra. de l'Institut, s/n, 43206 Reus, Tarragona, Spain. muletb@peremata.com
authors.forename: B
authors.initials: B
authors.lastname: Mulet
authors.forename: J
authors.initials: J
authors.lastname: Valero
authors.forename: A
authors.initials: A
authors.lastname: Gutiérrez-Zotes
authors.forename: C
authors.initials: C
authors.lastname: Montserrat
authors.forename: M J
authors.initials: MJ
authors.lastname: Cortés
authors.forename: M
authors.initials: M
authors.lastname: Jariod
authors.forename: L
authors.initials: L
authors.lastname: Martorell
authors.forename: E
authors.initials: E
authors.lastname: Vilella
authors.forename: A
authors.initials: A
authors.lastname: Labad
mesh_terms: D000328:Adult; D001289:Attention Deficit Disorder with Hyperactivity / Q000235:genetics*; D042241:Early Diagnosis; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests / Q000706:statistics & numerical data; D010641:Phenotype; D011594:Psychometrics / Q000706:statistics & numerical data; D011618:Psychotic Disorders / Q000175:diagnosis / Q000235:genetics* / Q000523:psychology; D012016:Reference Values; D012559:Schizophrenia / Q000175:diagnosis / Q000235:genetics*; D012565:Schizophrenic Psychology; D013030:Spain