[Experimental research on the liver-qi stasis induced erectile dysfunction by mouse model].
OBJECTIVE
To establish a mouse model of erectile dysfunction (ED) induced by liver-qi stasis for observing the changes in the mouse's sex organs and investigating the possible mechanism of ED.


METHODS
Seventy-two Kunming mice, 24 males and 48 females, were randomly divided into a liver-qi stasis group, a severe liver-qi stasis group and a control group. A stressing box was used to exert gradual stress on the mice of the two experimental groups by confining them to the box and gradually reducing their room of movement so as to induce liver-qi stasis. In addition, the males of the severe liver-qi stasis group were further prohibited from any sexual activities to repress their sexual desire and intensify their liver-qi stasis.


RESULTS
Obvious differences were observed in the autonomous behavior, sexual activity and body weight of the mice of the three groups. Pathological examination showed that the sex organ indexes descended in the liver-qi stasis group and even further in the severe liver-qi stasis group as compared with the controls.


CONCLUSIONS
The stressing box can induce and intensify ED associated with liver-qi stasis.
Zhang
Li-Xia
LX
Department of Basic Sciences, Changchun College of TCM, Changchun, Jilin 130117, China. JL-ZLX@163.com
Wang
Hui
H
D000818:Animals; D004195:Disease Models, Animal; D007172:Erectile Dysfunction / Q000503:physiopathology*; D005260:Female; D008297:Male; D008516:Medicine, Chinese Traditional; D051379:Mice; D008815:Mice, Inbred Strains; D019413:Qi; D011897:Random Allocation