Influence of pravastatin on carotid artery structure and function in dyslipidemic HIV-infected patients receiving antiretroviral therapy.
Forty-two pravastatin-treated HIV-positive patients and 42 sex, age, and smoking status-matched hypercholesterolemic HIV-positive patients not under lipid-lowering treatment were compared for differences in intima-media thickness (IMT) of the common carotid artery (CCA) and aortic stiffness. Pravastatin had no influence on carotid artery structure and function, or aortic stiffness. Age and body mass index were independent determinants of IMT of the CCA. Mean arterial pressure, age, duration of HIV infection and protease inhibitor exposure determined aortic stiffness.
Boccara
Franck
F
Department of Pharmacology, Université Paris-Descartes, Faculté de Médecine, INSERM 652, Hôpital Européen Georges Pompidou, Paris, France.
Simon
Tabassome
T
Lacombe
Karine
K
Cohen
Ariel
A
Laloux
Brigitte
B
Bozec
Erwan
E
Durant
Stéphanie
S
Girard
Pierre-Marie
PM
Laurent
Stéphane
S
Boutouyrie
Pierre
P
D000367:Age Factors; D000924:Anticholesteremic Agents / Q000627:therapeutic use*; D023241:Antiretroviral Therapy, Highly Active / Q000379:methods; D001011:Aorta / Q000187:drug effects / Q000473:pathology; D001794:Blood Pressure / Q000502:physiology; D015992:Body Mass Index; D017536:Carotid Artery, Common / Q000187:drug effects* / Q000473:pathology; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D006937:Hypercholesterolemia / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D017035:Pravastatin / Q000627:therapeutic use*; D013997:Time Factors; D016896:Treatment Outcome; D017539:Tunica Intima / Q000187:drug effects / Q000473:pathology
D000924:Anticholesteremic Agents; D017035:Pravastatin