title: Unexpected acetylcholinesterase activity of cocaine esterases.
abstract: A series of proteins with cocaine esterase ability have been shown to hydrolyze acetylcholine with similar rate enhancements. Docking studies revealed that acetylcholine binds in a similar orientation as cocaine. These results suggest that acetylcholinesterase activity may be inherent to cocaine esterases.
authors.affiliation: Department of Chemistry, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.
authors.forename: Claude J
authors.initials: CJ
authors.lastname: Rogers
authors.forename: Lisa M
authors.initials: LM
authors.lastname: Eubanks
authors.forename: Tobin J
authors.initials: TJ
authors.lastname: Dickerson
authors.forename: Kim D
authors.initials: KD
authors.lastname: Janda
mesh_terms: D000110:Acetylcholinesterase / Q000737:chemistry* / Q000276:immunology / Q000378:metabolism; D017151:Antibodies, Catalytic / Q000276:immunology / Q000494:pharmacology; D000911:Antibodies, Monoclonal / Q000276:immunology / Q000494:pharmacology; D001665:Binding Sites; D002265:Carboxylic Ester Hydrolases / Q000737:chemistry* / Q000276:immunology / Q000378:metabolism; D002384:Catalysis; D003042:Cocaine / Q000737:chemistry*; D019970:Cocaine-Related Disorders / Q000188:drug therapy / Q000201:enzymology; D003461:Crystallography; D006801:Humans; D006868:Hydrolysis; D008958:Models, Molecular; D013379:Substrate Specificity
chemical_list: D017151:Antibodies, Catalytic; D000911:Antibodies, Monoclonal; D002265:Carboxylic Ester Hydrolases; C019921:cocaine esterase; D000110:Acetylcholinesterase; D003042:Cocaine