title: Myeloid C-type lectins in innate immunity.
abstract: C-type lectins expressed on myeloid cells comprise a family of proteins that share a common structural motif, and some act as receptors in pathogen recognition. But just as the presence of leucine-rich repeats alone is not sufficient to define a Toll-like receptor, the characterization of C-type lectin receptors in innate immunity requires the identification of accompanying signaling motifs. Here we focus on the known signaling pathways of myeloid C-type lectins and on their possible functions as autonomous activating or inhibitory receptors involved in innate responses to pathogens or self.
authors.affiliation: Immunobiology Laboratory, Cancer Research UK, London Research Institute, London WC2A 3PX, United Kingdom.
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Robinson
authors.forename: David
authors.initials: D
authors.lastname: Sancho
authors.forename: Emma C
authors.initials: EC
authors.lastname: Slack
authors.forename: Salomé
authors.initials: S
authors.lastname: LeibundGut-Landmann
authors.forename: Caetano
authors.initials: C
authors.lastname: Reis e Sousa
mesh_terms: D000818:Animals; D006801:Humans; D007113:Immunity, Innate; D007239:Infections / Q000276:immunology*; D037181:Lectins, C-Type / Q000276:immunology*; D051192:Receptors, Pattern Recognition / Q000276:immunology
chemical_list: D037181:Lectins, C-Type; D051192:Receptors, Pattern Recognition