title: Modafinil and cocaine interactions.
abstract: This Phase I trial evaluated the interaction between modafinil steady-state and cocaine. Twelve non-treatment seeking, cocaine dependent volunteers received four sets of randomized blinded infusions of saline, 20 mg IV cocaine, and 40 mg IV cocaine. Modafinil was given open label at 0 mg, 400 mg, or 800 mg. Modafinil combined with IV cocaine did not result in any significant hemodynamic interactions. Modafinil significantly dampened scores on Visual Analog Scale measures as compared to baseline cocaine conditions. No significant alterations in labs occurred. Further outpatient trials of modafinil appear to be warranted.
authors.affiliation: Center for Drug and Alcohol Programs, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA. malcolmr@musc.edu
authors.forename: Robert
authors.initials: R
authors.lastname: Malcolm
authors.forename: Karla
authors.initials: K
authors.lastname: Swayngim
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Donovan
authors.forename: C Lindsay
authors.initials: CL
authors.lastname: DeVane
authors.forename: Ahmed
authors.initials: A
authors.lastname: Elkashef
authors.forename: Nora
authors.initials: N
authors.lastname: Chiang
authors.forename: Roberta
authors.initials: R
authors.lastname: Khan
authors.forename: Jurij
authors.initials: J
authors.lastname: Mojsiak
authors.forename: Donald L
authors.initials: DL
authors.lastname: Myrick
authors.forename: Sarra
authors.initials: S
authors.lastname: Hedden
authors.forename: Kristi
authors.initials: K
authors.lastname: Cochran
authors.forename: Robert F
authors.initials: RF
authors.lastname: Woolson
mesh_terms: D001559:Benzhydryl Compounds / Q000008:administration & dosage / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D003042:Cocaine / Q000008:administration & dosage; D019970:Cocaine-Related Disorders / Q000188:drug therapy*; D004347:Drug Interactions; D006801:Humans; D007262:Infusions, Intravenous; D000077408:Modafinil; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D012449:Safety; D016896:Treatment Outcome
chemical_list: D001559:Benzhydryl Compounds; D018696:Neuroprotective Agents; D003042:Cocaine; D000077408:Modafinil