Impairments in spatial memory retention of GFAP-apoE4 female mice.
The human apolipoprotein E isoforms, apoE2, apoE3, and apoE4, have differential effects on brain function. Compared to apoE3, apoE4 increases the risk of age-related cognitive decline in humans and female mice expressing apoE in neurons. Here, we show impaired spatial memory retention in female mice expressing apoE4 in astrocytes compared to those expressing apoE3 in astrocytes or lacking apoE. Thus, apoE4 impairs cognition whether expressed in neurons or astrocytes.
van Meer
Peter
P
Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR 97239, United States.
Acevedo
Summer
S
Raber
Jacob
J
D000704:Analysis of Variance; D000818:Animals; D053327:Apolipoprotein E4 / Q000172:deficiency / Q000502:physiology*; D001253:Astrocytes / Q000378:metabolism; D001522:Behavior, Animal; D001921:Brain / Q000473:pathology; D005260:Female; D005904:Glial Fibrillary Acidic Protein / Q000502:physiology*; D018782:Maze Learning / Q000502:physiology; D008569:Memory Disorders / Q000235:genetics* / Q000473:pathology*; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D009474:Neurons / Q000378:metabolism; D011930:Reaction Time / Q000235:genetics; D013037:Spatial Behavior / Q000502:physiology*
D053327:Apolipoprotein E4; D005904:Glial Fibrillary Acidic Protein