title: Aspirin may be more effective in preventing colorectal adenomas in patients with higher BMI (United States).
abstract: Obesity is a risk factor for colon cancer, possibly due to elevated levels of circulating cytokines derived from adipose tissue. Aspirin, which may affect the levels of these cytokines, has been shown in randomized controlled trials to decrease the risk of colorectal adenomas. We hypothesized that the chemopreventive effect of aspirin might be greater in individuals with higher body mass index (BMI). Data were available from the Aspirin/Folate Polyp Prevention Study, a randomized controlled trial of aspirin and folic acid to prevent recurrent colorectal adenomas. Obesity was defined as BMI > or = 30 (kg/m2), overweight as BMI of 25-29 (kg/m2) and normal weight as BMI <25 (kg/m2). For the analysis of the effect of aspirin on the recurrence of colorectal adenoma by BMI, we computed risk ratios for aspirin versus placebo within the three BMI strata using a modified Poisson model. Overall the risk reduction of adenomas with a daily dose of 325 mg aspirin was greater among subjects with higher BMI. Among obese subjects the risk ratio (RR) for advanced adenomas compared with placebo was 0.44 (95% CI 0.17-1.10), versus RR = 1.23 (95% CI 0.55-2.77) among those with normal weight. However, 81 mg aspirin daily did not interact with BMI to modify the risk of adenomas in such a fashion. The more pronounced effect of 325 mg aspirin in individuals with higher BMI suggests a possible protective role of anti-inflammatory aspirin against increased adipose-driven cytokines among obese subjects.
authors.affiliation: Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC 27599-7555, USA.
authors.forename: Sangmi
authors.initials: S
authors.lastname: Kim
authors.forename: John A
authors.initials: JA
authors.lastname: Baron
authors.forename: Leila A
authors.initials: LA
authors.lastname: Mott
authors.forename: Carol A
authors.initials: CA
authors.lastname: Burke
authors.forename: Timothy R
authors.initials: TR
authors.lastname: Church
authors.forename: Gail E
authors.initials: GE
authors.lastname: McKeown-Eyssen
authors.forename: Bernard F
authors.initials: BF
authors.lastname: Cole
authors.forename: Robert W
authors.initials: RW
authors.lastname: Haile
authors.forename: Robert S
authors.initials: RS
authors.lastname: Sandler
mesh_terms: D018256:Adenomatous Polyps / Q000517:prevention & control*; D001241:Aspirin / Q000494:pharmacology*; D015992:Body Mass Index; D015179:Colorectal Neoplasms / Q000517:prevention & control*; D016001:Confidence Intervals; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D012008:Recurrence; D014481:United States
chemical_list: D001241:Aspirin