title: [Topic use of aqueous extract of Orbignya phalerata (babassu) in rats: analysis of its healing effect].
abstract: BACKGROUND
  The mesocarp of Babassu (Orbignya phalerata) has been used in experimental studies trying to check its pro-inflammatory effect.
  
  
  OBJECTIVE
  To analyse comparatively the histological changes made by the water extract of Babassu in skin surgical wounds.
  
  
  METHODS
  Sixty Wistar adult male rats were used. The experimental procedure was a circle skin incision of 2 cm in diameter made with a metal punch. After this procedure done in all animals, they were randomized in two groups of 30. In the control group, the phytotherapeutic agent wasn't used but saline solution. In the experimental group, the water extract of Orbignya phalerata was used in the cut sites. All animals were followed and killed after seven, 14 and 21 days. Comparative histological analysis was made among the groups.
  
  
  RESULTS
  In the microscopic view, a significant reepitelization effect on the healing process of the experimental group in relation to the control group in the 7th and 14th days, was recognized.
  
  
  CONCLUSIONS
  The use of the mesocarp of Orbignya phalerata in skin surgical wounds contributed positively in the healing process in rats.
authors.affiliation: Hospital, Universidade Federal do Maranhao.
authors.forename: Elias
authors.initials: E
authors.lastname: Amorim
authors.forename: Jorge Eduardo F
authors.initials: JE
authors.lastname: Matias
authors.forename: Júlio Cézar U
authors.initials: JC
authors.lastname: Coelho
authors.forename: Antonio Carlos L
authors.initials: AC
authors.lastname: Campos
authors.forename: Henrique Jorge
authors.initials: HJ
authors.lastname: Stahlke
authors.forename: Jorge Rufino Ribas
authors.initials: JR
authors.lastname: Timi
authors.forename: Luiz Carlos de Almeida
authors.initials: LC
authors.lastname: Rocha
authors.forename: Ana Tereza Ramos
authors.initials: AT
authors.lastname: Moreira
authors.forename: Daniel Zeni
authors.initials: DZ
authors.lastname: Rispoli
authors.forename: Lydia Masako
authors.initials: LM
authors.lastname: Ferreira
mesh_terms: D000287:Administration, Topical; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D003059:Cocos / Q000737:chemistry*; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use; D011184:Postoperative Period; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D012867:Skin / Q000293:injuries* / Q000648:ultrastructure; D013997:Time Factors; D014945:Wound Healing / Q000187:drug effects* / Q000502:physiology
chemical_list: D000893:Anti-Inflammatory Agents; D010936:Plant Extracts