Diagnosis of chronic mesenteric ischemia by visible light spectroscopy during endoscopy.
BACKGROUND
Chronic mesenteric ischemia can be difficult to diagnose by means of currently available clinical techniques. We developed a novel endoscopic device for objective measurement of GI mucosal ischemia.


OBJECTIVE
Our purpose was to evaluate the performance of the device in patients with chronic mesenteric ischemia.


METHODS
A fiberoptic catheter-based visible light spectroscopy oximeter (T-Stat 303 Microvascular Oximeter, Spectros, Portola Valley, Calif) was used to evaluate 30 healthy control subjects and 3 patients with chronic mesenteric ischemia before and after successful percutaneous stenting.


METHODS
Veterans Affairs Palo Alto Health Care System hospital.


RESULTS
Normal mucosal (capillary) hemoglobin oxygen saturation was 60% to 73% in the duodenum and jejunum. In the 3 patients with chronic mesenteric ischemia, ischemic areas in the duodenum or proximal jejunum were found with mucosal saturations of 16% to 30%. After successful angioplasty and stent placement of the celiac, superior mesenteric, or inferior mesenteric arteries, the mucosal saturation in these areas increased to 51% to 60%.


CONCLUSIONS
This preliminary study suggests that chronic mesenteric ischemia is detectable during endoscopy by use of visible light spectroscopy and that successful endovascular treatment results in near normalization of mucosal oxygen saturation.
Friedland
Shai
S
Veterans Administration Palo Alto Health Care System, Palo Alto, California 94305, USA.
Benaron
David
D
Coogan
Sheila
S
Sze
Daniel Y
DY
Soetikno
Roy
R
D000368:Aged; D002908:Chronic Disease; D016099:Endoscopy, Gastrointestinal; D005260:Female; D006801:Humans; D007413:Intestinal Mucosa / Q000098:blood supply*; D007511:Ischemia / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy; D008027:Light; D008297:Male; D008641:Mesenteric Vascular Occlusion / Q000150:complications / Q000175:diagnosis / Q000628:therapy; D008643:Mesentery / Q000098:blood supply; D008875:Middle Aged; D010092:Oximetry; D013057:Spectrum Analysis / Q000379:methods*; D015607:Stents