title: Spatial and temporal expression of POF1B, a gene expressed in epithelia.
abstract: Mammalian epithelia possess specialized cellular components that provide an impermeable barrier between two different environments. In particular, in the skin, mitotically dividing cells undergo a programmed set of morphological and biochemical changes leading to the establishment of the epidermal permeability barrier (EPB) to prevent escape of moisture and entrance of toxic molecules. Many different skin proteins are involved in the process but not all have been identified. We report here the results of the expression studies of a novel gene, highly and specifically expressed in the granular layer of the epidermis and in the epithelia of the oro-pharyngeal and gastro-intestinal tracts. Our data show that during mouse development Pof1b expression is activated in the external layers of the epidermis just prior to formation of the EPB.
authors.affiliation: DIBIT, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milano, Italy.
authors.forename: Flavio
authors.initials: F
authors.lastname: Rizzolio
authors.forename: Silvia
authors.initials: S
authors.lastname: Bione
authors.forename: Antonello
authors.initials: A
authors.lastname: Villa
authors.forename: Emilio
authors.initials: E
authors.lastname: Berti
authors.forename: Arianna
authors.initials: A
authors.lastname: Cassetti
authors.forename: Alessandro
authors.initials: A
authors.lastname: Bulfone
authors.forename: Carla
authors.initials: C
authors.lastname: Tribioli
authors.forename: Daniela
authors.initials: D
authors.lastname: Toniolo
mesh_terms: D000818:Animals; D015152:Blotting, Northern; D004622:Embryo, Mammalian / Q000378:metabolism; D004817:Epidermis / Q000196:embryology* / Q000378:metabolism; D004848:Epithelium / Q000378:metabolism; D015870:Gene Expression; D006801:Humans; D051379:Mice; D008840:Microfilament Proteins / Q000235:genetics*; D011506:Proteins / Q000235:genetics* / Q000502:physiology
chemical_list: D008840:Microfilament Proteins; C500687:POF1B protein, human; C519668:POF1B protein, mouse; D011506:Proteins