title: Association of hyperadiponectinemia with severity of ventricular dysfunction in congestive heart failure.
abstract: BACKGROUND
  Adiponectin, which is a collagen-like plasma protein produced by adipose tissue, has anti-atherogenic and anti-inflammatory effects. Plasma adiponectin levels in patients with congestive heart failure (CHF) were determined, as well as relationships between the plasma levels of adiponectin and other hormones.
  
  
  RESULTS
  The study group comprised 90 patients with CHF and 20 control subjects, who were divided into 4 subgroups according to New York Heart Association (NYHA) functional class. Plasma levels of adiponectin, tumor necrosis factor (TNF)-alpha and brain natriuretic peptide (BNP) and cardiac hemodynamics were determined. Plasma adiponectin levels were significantly increased according to the severity of NYHA class in the patients with CHF; control: 6.2+/-1.0; NYHA I: 8.5+/-1.9, NYHA II: 12.0+/-2.2, NYHA III: 13.0+/-2.7, NYHA IV: 14.9+/-2.7 microg/ml (p=0.0008). Similarly, plasma BNP levels were significantly increased in accordance with the NYHA class. Plasma adiponectin levels correlated positively with BNP (r=0.40, p=0.0002) and TNF-alpha (r=0.49, p=0.0001), and correlated negatively with cardiac index (r=-0.27, p=0.05). In 24 of 46 patients in the NYHA III and IV subgroups, according to the prompt improvement in cardiac function, levels of both plasma adiponectin and BNP were significantly reduced (p<0.0001).
  
  
  CONCLUSIONS
  Plasma adiponectin levels increased according to the severity of CHF and, moreover, they correlated with the plasma levels of BNP and TNF-alpha. These results indicate that augmented release of adiponectin is involved in the pathogenesis of CHF and further study is needed to elucidate its exact role.
authors.affiliation: Department of Medicine, Jichi Medical University Omiya Medical Center, Saitama. Japan.
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Nakamura
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Funayama
authors.forename: Norifumi
authors.initials: N
authors.lastname: Kubo
authors.forename: Takanori
authors.initials: T
authors.lastname: Yasu
authors.forename: Masanobu
authors.initials: M
authors.lastname: Kawakami
authors.forename: Muneyasu
authors.initials: M
authors.lastname: Saito
authors.forename: Shin-ichi
authors.initials: S
authors.lastname: Momomura
authors.forename: San-E
authors.initials: SE
authors.lastname: Ishikawa
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000368:Aged; D005260:Female; D006333:Heart Failure / Q000097:blood* / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D018754:Ventricular Dysfunction / Q000503:physiopathology*
chemical_list: D052242:Adiponectin; D014409:Tumor Necrosis Factor-alpha; D020097:Natriuretic Peptide, Brain