Unexpected acetylcholinesterase activity of cocaine esterases.
A series of proteins with cocaine esterase ability have been shown to hydrolyze acetylcholine with similar rate enhancements. Docking studies revealed that acetylcholine binds in a similar orientation as cocaine. These results suggest that acetylcholinesterase activity may be inherent to cocaine esterases.
Rogers
Claude J
CJ
Department of Chemistry, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.
Eubanks
Lisa M
LM
Dickerson
Tobin J
TJ
Janda
Kim D
KD
D000110:Acetylcholinesterase / Q000737:chemistry* / Q000276:immunology / Q000378:metabolism; D017151:Antibodies, Catalytic / Q000276:immunology / Q000494:pharmacology; D000911:Antibodies, Monoclonal / Q000276:immunology / Q000494:pharmacology; D001665:Binding Sites; D002265:Carboxylic Ester Hydrolases / Q000737:chemistry* / Q000276:immunology / Q000378:metabolism; D002384:Catalysis; D003042:Cocaine / Q000737:chemistry*; D019970:Cocaine-Related Disorders / Q000188:drug therapy / Q000201:enzymology; D003461:Crystallography; D006801:Humans; D006868:Hydrolysis; D008958:Models, Molecular; D013379:Substrate Specificity
D017151:Antibodies, Catalytic; D000911:Antibodies, Monoclonal; D002265:Carboxylic Ester Hydrolases; C019921:cocaine esterase; D000110:Acetylcholinesterase; D003042:Cocaine