title: [A pregnant woman with nephrotic syndrome and focal segmental lesions].
abstract: A 32-year-old woman was admitted at 36 weeks' gestation because of increasing proteinuria and generalized edema. At the time of admission, serum creatinine was 1.3 mg/dl, and urinalysis demonstrated 4+ protein and 2+ occult blood. During her pregnancy, her blood pressure had been in the normal range. A normal healthy female neonate was delivered by caesarean section at 38 weeks' gestation. After delivery, the woman's 24-hour urine protein excretion was 11 g/day and serum albumin was 1.4 g/dl , hence nephrotic syndrome was diagnosed. Eleven days after delivery, a renal biopsy showed focal segmental lesions with glomerular epithelial cell injury. She was given 50 mg/day prednisolone and after a month, her 24-hour urinary protein excretion decreased to 2 g/day. One year later, she achieved complete remission. Although she had a relapse of nephrotic syndrome after twenty-one months, steroid therapy again achieved a good response.
authors.affiliation: Department of Nephrology, Tokyo Medical University, Tokyo, Japan.
authors.forename: Toshikazu
authors.initials: T
authors.lastname: Wada
authors.forename: Yume
authors.initials: Y
authors.lastname: Nagaoka
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Matsumoto
authors.forename: Tomonari
authors.initials: T
authors.lastname: Okada
authors.forename: Myeonggi
authors.initials: M
authors.lastname: Han
authors.forename: Maki
authors.initials: M
authors.lastname: Yoshino
authors.forename: Hideaki
authors.initials: H
authors.lastname: Iwasawa
authors.forename: Ryou
authors.initials: R
authors.lastname: Tomaru
authors.forename: Asako
authors.initials: A
authors.lastname: Uchinaga
authors.forename: Tokiyo
authors.initials: T
authors.lastname: Ake
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Nakao
authors.forename: Toshitaka
authors.initials: T
authors.lastname: Nagao
mesh_terms: D000328:Adult; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage; D005260:Female; D005923:Glomerulosclerosis, Focal Segmental / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D006801:Humans; D009404:Nephrotic Syndrome / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D011239:Prednisolone / Q000008:administration & dosage; D011247:Pregnancy; D011248:Pregnancy Complications
chemical_list: D000893:Anti-Inflammatory Agents; D011239:Prednisolone