title: Vascular type of Ehlers-Danlos syndrome in a patient with ruptured aneurysm of the splenic artery.
abstract: A 39-year-old woman presented with a ruptured aneurysm of the splenic artery. The postoperative course was complicated by poor wound healing. This, in combination with a history of easy bruising and joint hypermobility, made us consider a connective tissue disease as underlying cause. The vascular type of Ehlers-Danlos syndrome was diagnosed by identifying collagen III deficiency and the corresponding gene mutation in cultured fibroblasts from a skin biopsy.
authors.affiliation: Department of Internal Medicine, VU University Medical Centre, Amsterdam, the Netherlands. p.nanayakkara@vumc.nl
authors.forename: P W B
authors.initials: PW
authors.lastname: Nanayakkara
authors.forename: C C
authors.initials: CC
authors.lastname: van Bunderen
authors.forename: S
authors.initials: S
authors.lastname: Simsek
authors.forename: Y M
authors.initials: YM
authors.lastname: Smulders
authors.forename: G
authors.initials: G
authors.lastname: Pals
mesh_terms: D000328:Adult; D017542:Aneurysm, Ruptured / Q000209:etiology*; D004535:Ehlers-Danlos Syndrome / Q000150:complications* / Q000175:diagnosis; D005260:Female; D006801:Humans; D013157:Splenic Artery