title: Distributions of positron-emitting nuclei in proton and carbon-ion therapy studied with GEANT4.
abstract: Depth distributions of positron-emitting nuclei in PMMA phantoms are calculated within a Monte Carlo model for heavy-ion therapy (MCHIT) based on the GEANT4 toolkit (version 8.0). The calculated total production rates of (11)C, (10)C and (15)O nuclei are compared with experimental data and with corresponding results of the FLUKA and POSGEN codes. The distributions of e(+) annihilation points are obtained by simulating radioactive decay of unstable nuclei and transporting positrons in the surrounding medium. A finite spatial resolution of the positron emission tomography (PET) is taken into account in a simplified way. Depth distributions of beta(+)-activity as seen by a PET scanner are calculated and compared to available data for PMMA phantoms. The obtained beta(+)-activity profiles are in good agreement with PET data for proton and (12)C beams at energies suitable for particle therapy. The MCHIT capability to predict the beta(+)-activity and dose distributions in tissue-like materials of different chemical composition is demonstrated.
authors.affiliation: Frankfurt Institute for Advanced Studies, Johann Wolfgang Goethe University, 60438 Frankfurt am Main, Germany. pshenich@fias.uni-frankfurt.de
authors.forename: Igor
authors.initials: I
authors.lastname: Pshenichnov
authors.forename: Igor
authors.initials: I
authors.lastname: Mishustin
authors.forename: Walter
authors.initials: W
authors.lastname: Greiner
mesh_terms: D055592:Biophysical Phenomena; D001703:Biophysics; D002244:Carbon; D004583:Electrons / Q000627:therapeutic use*; D006801:Humans; D009010:Monte Carlo Method; D009369:Neoplasms / Q000000981:diagnostic imaging / Q000532:radiotherapy; D019047:Phantoms, Imaging; D019904:Polymethyl Methacrylate; D049268:Positron-Emission Tomography; D061766:Proton Therapy; D011880:Radiotherapy Planning, Computer-Assisted / Q000706:statistics & numerical data*; D012984:Software
chemical_list: D002244:Carbon; D019904:Polymethyl Methacrylate