title: Beneficial associations of physical activity with 2-h but not fasting blood glucose in Australian adults: the AusDiab study.
abstract: OBJECTIVE
  We examined the associations of physical activity with fasting plasma glucose (FPG) and with 2-h postload plasma glucose (2-h PG) in men and women with low, moderate, and high waist circumference.
  
  
  METHODS
  The Australian Diabetes, Obesity and Lifestyle (AusDiab) study provided data on a population-based cross-sectional sample of 4,108 men and 5,106 women aged >or=25 years without known diabetes or health conditions that could affect physical activity. FPG and 2-h PG were obtained from an oral glucose tolerance test. Self-reported physical activity level was defined according to the current public health guidelines as active (>or=150 min/week across five or more sessions) or inactive (<150 min/week and/or less than five sessions). Sex-specific quintiles of physical activity time were used to ascertain dose response.
  
  
  RESULTS
  Being physically active and total physical activity time were independently and negatively associated with 2-h PG. When physical activity level was considered within each waist circumference category, 2-h PG was significantly lower in active high-waist circumference women (beta -0.30 [95% CI -0.59 to -0.01], P = 0.044) and active low-waist circumference men (beta -0.25 [-0.49 to -0.02], P = 0.036) compared with their inactive counterparts. Considered across physical activity and waist circumference categories, 2-h PG levels were not significantly different between active moderate-waist circumference participants and active low-waist circumference participants. Associations between physical activity and FPG were nonsignificant.
  
  
  CONCLUSIONS
  There are important differences between 2-h PG and FPG related to physical activity. It appears that 2-h PG is more sensitive to the beneficial effects of physical activity, and these benefits occur across the waist circumference spectrum.
authors.affiliation: Cancer Prevention Research Centre, School of Population Health, University of Queensland, Herston, Queensland, Australia 4006. g.healy@uq.edu.au
authors.forename: Genevieve N
authors.initials: GN
authors.lastname: Healy
authors.forename: David W
authors.initials: DW
authors.lastname: Dunstan
authors.forename: Jonathan E
authors.initials: JE
authors.lastname: Shaw
authors.forename: Paul Z
authors.initials: PZ
authors.lastname: Zimmet
authors.forename: Neville
authors.initials: N
authors.lastname: Owen
mesh_terms: D000328:Adult; D001315:Australia / Q000453:epidemiology; D001786:Blood Glucose / Q000378:metabolism*; D003430:Cross-Sectional Studies; D003920:Diabetes Mellitus / Q000453:epidemiology; D005215:Fasting; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009043:Motor Activity / Q000502:physiology*; D019518:Postprandial Period; D015995:Prevalence; D012727:Sex Characteristics
chemical_list: D001786:Blood Glucose