title: An aggressive surgical approach leads to long-term survival in patients with pancreatic endocrine tumors.
abstract: OBJECTIVE
  To evaluate the outcome of reoperations in patients with duodenopancreatic neuroendocrine tumors (PETs) in a tertiary referral center.
  
  
  BACKGROUND
  The management of reoperations in PETs is still controversial.
  
  
  METHODS
  A total of 125 patients with PETs that underwent surgery between 1987 and 2004 at our institution were retrospectively evaluated. The diagnosis of PETs was based on clinical symptoms, biochemical tests, and histopathology. Patients with at least one reoperation were analyzed regarding clinical characteristics, pathology, operations, and long-term follow-up.
  
  
  RESULTS
  A total of 33 patients with a median age of 42 years were identified for this study: 13 patients had gastrinomas, 12 patients had nonfunctional islet cell tumors, 6 patients had insulinomas, and 2 patients had vipomas; 24 patients had sporadic NETs, 9 patients had a MEN-1-syndrome; 27 patients had histologically verified malignant tumors; 33 initial operations and 50 reoperations were performed. The initial procedures comprised 27 resections of the primary tumor and 6 explorative laparotomies; 28 of all reoperations were resections of distant metastases, including 15 liver resections; 19 resections of the pancreas or duodenum were performed during reoperations. The overall morbidity and mortality was 45% and 4.8%, respectively. After a median follow-up of 124 months (range, 16-384 months), 27 of 33 patients are still alive, 12 without evidence of disease. All 6 patients with benign tumors are still alive. The 5-, 10-, and actuarial 25-year survival rate for patients with malignant tumors were 81%, 72%, and 36%, respectively. The survival rate was significantly related to the patients age at time of initial operation and better in patients younger than 50 years compared with patients older than 50 years (P = 0.0007), and the presence or development of metastases (none or lymph node metastases versus distant metastases: P = 0.01).
  
  
  CONCLUSIONS
  We show that an aggressive surgical approach leads to long-term survival in patients with malignant PETs. Although long-term cure can only be achieved in a proportion of patients with malignant PETs, significant long-term palliation can be achieved.
authors.affiliation: Department of Surgery, Philipps-University Marburg, Marburg, Germany. fendrich@med.uni-marburg.de
authors.forename: Volker
authors.initials: V
authors.lastname: Fendrich
authors.forename: Peter
authors.initials: P
authors.lastname: Langer
authors.forename: Ilhan
authors.initials: I
authors.lastname: Celik
authors.forename: Detlef K
authors.initials: DK
authors.lastname: Bartsch
authors.forename: Andreas
authors.initials: A
authors.lastname: Zielke
authors.forename: Anette
authors.initials: A
authors.lastname: Ramaswamy
authors.forename: Matthias
authors.initials: M
authors.lastname: Rothmund
mesh_terms: D000328:Adult; D013505:Digestive System Surgical Procedures; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008197:Lymph Node Excision; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000401:mortality* / Q000473:pathology / Q000601:surgery*; D012086:Reoperation; D012189:Retrospective Studies; D015996:Survival Rate; D016896:Treatment Outcome