A strain of Salmonella enterica serovar Virchow isolated in Turkey and carrying a CTX-M-3 extended-spectrum beta-lactamase.
A multiply resistant strain of Salmonella enterica subsp. enterica serovar Virchow was isolated in November 2002 from a catheterized patient admitted to the SSK Training Hospital in Ankara, Turkey. This isolate showed an antimicrobial susceptibility pattern compatible with the presence of a CTX-M-type ESBL, namely resistance to cefotaxime, aztreonam and cefepime, and intermediate susceptibility to ceftazidime. On checking for the presence of the bla(TEM), bla(SHV), and bla(CTX-M )resistance genes by PCR, negative results were obtained with the primers specific for SHV and TEM genes, while positive results were obtained with those specific for CTX-M-type genes. After sequencing, the beta-lactamase was identified as CTX-M-3. This is the first report of this enzyme in Salmonella Virchow and represents a further disquieting threat to the therapy of infections caused by Salmonella isolates.
Bahar
G
G
Clinical Microbiology, SSK Training Hospital, Ankara, Turkey.
Mert
A
A
Catania
M R
MR
Koncan
R
R
Benvenuti
C
C
Mazzariol
A
A
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D024901:Drug Resistance, Multiple, Bacterial; D006784:Hospitals, Teaching; D006801:Humans; D016133:Polymerase Chain Reaction; D019779:Salmonella enterica / Q000187:drug effects / Q000235:genetics* / Q000302:isolation & purification; D014421:Turkey; D014546:Urinary Catheterization; D001618:beta-Lactamases / Q000235:genetics*
D000900:Anti-Bacterial Agents; C417271:beta-lactamase CTX-M-3; D001618:beta-Lactamases