title: A prospective comparison of multidisciplinary treatment of oesophageal cancer with curative intent in a UK cancer network.
abstract: OBJECTIVE
  Combined modality therapy (with chemotherapy+/-radiotherapy) has become a standard treatment for locally advanced oesophageal cancer. However, there appears to be no compelling evidence for one treatment type or combination to suit all and at this time the clinical multi-disciplinary team (MDT) forms an important role in selecting optimal therapies for the individual. This prospective comparison in one cancer network, looks at the outcomes of this decision making process.
  
  
  METHODS
  Over a five year period 1998-2003, data were prospectively collected on all 330 consecutive patients, referred to a tertiary specialised MDT for whom curative treatment was the planned intent. Patients were managed according to an agreed local protocol and allocated to receive one of 5 treatments: surgery alone (S), pre-operative chemotherapy (C+S), pre-operative chemo-radiotherapy (CRT+S), definitive chemo-radiotherapy (CRT) and radiotherapy alone (RT).
  
  
  RESULTS
  The 2 and 5 year survival for all patients receiving potentially curative treatment were 49% and 26% respectively. With 2 and 5 year survival for S, CRT+S, C+S, CRT and RT being 53,21; 57,40; 37,27; 50,27; 23,0 months respectively. Of the surgical therapies, mortality was highest in the CRT+S group, versus C+S and S; 12.5%, 1.6%, 4.5% respectively (p=0.025). Non-surgical based therapies had more than double the incidence of local relapses compared to surgical based therapies; however the CRT group had an overall survival comparable with S alone. The commonest sites of distant relapse were liver (56%), lung (38%), bone (32%) and non-regional lymph nodes (24%).
  
  
  CONCLUSIONS
  The results suggest that in patients who are deemed unfit for surgical intervention, definitive chemoradiotherapy remains a viable alternative; they also lend further support to selected case triple modality therapy. These areas should be further examined in the context of randomised controlled phase III trials.
authors.affiliation: Velindre Cancer Centre, Velindre Road, Whitchurch, Cardiff CF14 2TL, UK.
authors.forename: R
authors.initials: R
authors.lastname: Adams
authors.forename: M
authors.initials: M
authors.lastname: Morgan
authors.forename: S
authors.initials: S
authors.lastname: Mukherjee
authors.forename: A
authors.initials: A
authors.lastname: Brewster
authors.forename: T
authors.initials: T
authors.lastname: Maughan
authors.forename: D
authors.initials: D
authors.lastname: Morrey
authors.forename: T
authors.initials: T
authors.lastname: Havard
authors.forename: W
authors.initials: W
authors.lastname: Lewis
authors.forename: G
authors.initials: G
authors.lastname: Clark
authors.forename: S
authors.initials: S
authors.lastname: Roberts
authors.forename: L
authors.initials: L
authors.lastname: Vachtsevanos
authors.forename: J
authors.initials: J
authors.lastname: Leong
authors.forename: R
authors.initials: R
authors.lastname: Hardwick
authors.forename: D
authors.initials: D
authors.lastname: Carey
authors.forename: T
authors.initials: T
authors.lastname: Crosby
mesh_terms: D000368:Aged; D003131:Combined Modality Therapy / Q000379:methods; D004938:Esophageal Neoplasms / Q000628:therapy*; D016629:Esophagectomy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D016016:Proportional Hazards Models; D011446:Prospective Studies; D016019:Survival Analysis; D016896:Treatment Outcome; D006113:United Kingdom