Pure sarcomatous recurrence of clear cell renal carcinoma following radical nephrectomy and dendritic cell vaccination.
BACKGROUND
Sarcomatous differentiation, which represents transformation to high-grade malignancy, can occur in all histological types of renal malignancy.


METHODS
The authors report on the case of a 66-year-old woman with a right renal mass that was shown to be a clear cell carcinoma. She underwent radical nephrectomy and dendritic cell vaccination and, 3.5 years later, she developed retroperitoneal pure sarcomatous recurrence of the tumor. The authors speculate that the vaccination could have played some role in this differentiation or selection of the sarcomatous component of the primary tumor.
Antunes
Alberto Azoubel
AA
Division of Urology, Faculdade de Medicina da Universidade de São Paulo, and Hospital Sírio-Libanês, São Paulo, Brazil.
Dall'Oglio
Marcos Francisco
MF
Barbuto
José Alexandre Marzagão
JA
Leite
Kátia Ramos Moreira
KR
Srougi
Miguel
M
D000368:Aged; D019496:Cancer Vaccines / Q000009:adverse effects / Q000627:therapeutic use*; D002292:Carcinoma, Renal Cell / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D003713:Dendritic Cells / Q000276:immunology; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D009392:Nephrectomy; D012008:Recurrence; D012186:Retroperitoneal Neoplasms / Q000556:secondary*; D012509:Sarcoma / Q000556:secondary*
D019496:Cancer Vaccines