Responses of the heart to ambient particle inhalation.
This article focuses on responses to ambient particles by the heart. Available data from human studies and animal studies are reviewed in an attempt to find a common understanding in the findings. The pathophysiologic mechanisms responsible for these health effects are likely to be complex, and it is highly probable that several different mechanisms work in concert. Current evidence suggests that inhaled particles exert their effects on the heart via the autonomic nervous system and via the coronary vasculature. Direct effects on the myocardium by inhaled ambient particles or their constituents require more research.
Godleski
John J
JJ
Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA. jgodlesk@hsph.harvard.edu
D000393:Air Pollutants / Q000633:toxicity*; D000397:Air Pollution / Q000009:adverse effects*; D001341:Autonomic Nervous System; D006321:Heart; D006331:Heart Diseases / Q000209:etiology*; D006801:Humans; D019570:Inhalation Exposure / Q000009:adverse effects*; D017202:Myocardial Ischemia / Q000209:etiology; D052638:Particulate Matter / Q000633:toxicity*; D018570:Risk Assessment; D012307:Risk Factors
D000393:Air Pollutants; D052638:Particulate Matter