title: Genetic distribution of group A human rotavirus types isolated in Gyunggi province of Korea, 1999-2002.
abstract: BACKGROUND
  Human rotavirus genotypes G1-G4 and G9 are the major etiological agents of infantile gastroenteritis. G1 was the most prevalent in Korea during the 10-year period prior to 1997. However, between 1998 and 1999, G4 was the predominant type in Korea, as it was in other Asian countries.
  
  
  OBJECTIVE
  The circulating pattern and genetic variability of group A human rotavirus in Gyunggi, Korea, 1999-2002, were examined in 189 stool specimens.
  
  
  METHODS
  Stool samples were collected from children with diarrhea, and group A human rotavirus type was determined using multiplex RT-PCR in those specimens found to be positive for rotavirus by ELISA. Each genotype was sequenced, and phylogenetic analysis was performed on the sequences.
  
  
  RESULTS
  We found significant variability from year to year in the prevalence of different G and P types of rotavirus. We also found relatively high prevalence rates for types normally considered to be uncommon. Furthermore, we found that the most prevalent combination of G and P types changed from year to year. Although the combination of G and P types changed every year, the sequence of G genotypes showed a high level of similarity (>97%) compared to those of strains from other Asian countries.
  
  
  CONCLUSIONS
  We report the types of rotavirus circulating in Gyunggi province, Korea from 1999 to 2002. This information on rotavirus diversity has important implications for rotavirus vaccine efficacy and future vaccine development.
authors.affiliation: Department of Microbiology, College of Medicine, Korea University, Seoul 136-705, Korea.
authors.forename: Sung-Sil
authors.initials: SS
authors.lastname: Moon
authors.forename: Yangsook Song
authors.initials: YS
authors.lastname: Green
authors.forename: Jin-Won
authors.initials: JW
authors.lastname: Song
authors.forename: Chang Nam
authors.initials: CN
authors.lastname: Ahn
authors.forename: Hoon
authors.initials: H
authors.lastname: Kim
authors.forename: Kwang Sook
authors.initials: KS
authors.lastname: Park
authors.forename: Ki-Joon
authors.initials: KJ
authors.lastname: Song
authors.forename: Jung Hwa
authors.initials: JH
authors.lastname: Lee
authors.forename: Luck Ju
authors.initials: LJ
authors.lastname: Baek
mesh_terms: D000956:Antigens, Viral / Q000235:genetics; D036022:Capsid Proteins / Q000235:genetics; D002675:Child, Preschool; D003967:Diarrhea / Q000821:virology*; D014644:Genetic Variation; D006801:Humans; D007223:Infant; D007723:Korea; D010802:Phylogeny; D012401:Rotavirus / Q000145:classification / Q000235:genetics*; D012400:Rotavirus Infections / Q000821:virology*; D013045:Species Specificity
chemical_list: D000956:Antigens, Viral; D036022:Capsid Proteins; C060339:VP4 protein, Rotavirus; C050779:VP7 protein, Rotavirus