The assessment of occupational exposure to diazinon in Nicaraguan plantation workers using saliva biomonitoring.
A cross-sectional study with repeated sample collection in multiple days was conducted to assess diazinon exposures. Saliva and limited blood samples were collected from 10 banana plantation workers involved with diazinon application and their children aged 2-12 years living in Chinandega, Nicaragua. Diazinon concentration-time profiles in saliva varied between two plantations, which reflects the differences of work practices in each plantation. Salivary concentrations of diazinon measured in Plantation 1 applicators continued to increase 2 days after self-reported diazinon application, suggesting an ongoing exposure among these workers. However, salivary diazinon concentrations measured in Plantation 2 applicators were peaked 12 h prior to the first application, and then decreased 36 h post the first application. Diazinon concentrations in saliva were significantly correlated with the time-matched plasma samples collected from the same workers, which is in agreement with the previous published data from animal models. Children's exposure to diazinon through take-home pathway does not exist, as evident by the majority of nondetected saliva samples, and this finding was confirmed by the results from the urine samples. Severe dehydration was observed in many plantation workers and their children, resulting in the loss of some saliva samples, which no doubt have impaired the overall quality of the study results. Regardless, this article has demonstrated that saliva can be used to assess exposures to diazinon in pesticide applicators and children.
Lu
Chensheng
C
Department of Environmental and Occupational Health, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA. clu2@sph.emory.edu
Rodríguez
Teresa
T
Funez
Aura
A
Irish
Rene S
RS
Fenske
Richard A
RA
D000328:Adult; D000383:Agriculture; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D003976:Diazinon / Q000032:analysis / Q000097:blood / Q000633:toxicity*; D004784:Environmental Monitoring; D006801:Humans; D007306:Insecticides / Q000032:analysis / Q000097:blood / Q000633:toxicity*; D009527:Nicaragua; D016273:Occupational Exposure; D015203:Reproducibility of Results; D012463:Saliva / Q000737:chemistry*
D007306:Insecticides; D003976:Diazinon