Effects of pre- and neonatal exposure to bisphenol A on murine brain development.
Bisphenol A (BPA), known as an environmental endocrine disrupter, is widely used in industry and dentistry. We investigated the effects of fetal and neonatal exposure to bisphenol A (BPA) on the brain development of mice. The density of tyrosine hydroxylase (TH)-immunoreactive (IR) neurons in substantia nigra was significantly decreased in BPA-exposed female mice (3 microg/g powder food), but not in the male mice, as compared with that of the control mice. The densities of calbindin D-28 K-, calretinin- and parvalbumin-IR neurons in the cerebral cortex were not different between BPA-exposed and the control mice. The present study indicates that chronic exposure of BPA during prenatal and neonatal periods causes a decrease of TH-positive neurons in substantia nigra only in female mice brain.
Tando
So
S
Department of Pathology and Applied Neurobiology, Kyoto Prefectural University of Medicine Graduate School of Medical Science, Kawaramachi Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan.
Itoh
Kyoko
K
Yaoi
Takeshi
T
Ikeda
Jun
J
Fujiwara
Yasuhiro
Y
Fushiki
Shinji
S
D000395:Air Pollutants, Occupational / Q000494:pharmacology*; D000818:Animals; D000831:Animals, Newborn; D001559:Benzhydryl Compounds; D001921:Brain / Q000187:drug effects* / Q000196:embryology* / Q000254:growth & development* / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004622:Embryo, Mammalian; D005260:Female; D018507:Gene Expression Regulation, Developmental / Q000187:drug effects; D008297:Male; D051379:Mice; D009419:Nerve Tissue Proteins / Q000378:metabolism; D010636:Phenols / Q000494:pharmacology*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D012737:Sex Factors; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism; D000098826:Bisphenol A Compounds
D000395:Air Pollutants, Occupational; D001559:Benzhydryl Compounds; D009419:Nerve Tissue Proteins; D010636:Phenols; D014446:Tyrosine 3-Monooxygenase; C006780:bisphenol A; D000098826:Bisphenol A Compounds