title: [Stimulation with 0,3 mg recombinant human thyrotropin (rhTSH) increases the effect of 131I therapy in patients with nontoxic nodular goiter. A prospective, randomized, double-blind trial--secondary publication].
abstract: In a randomized, double-blind, placebo-controlled trial, 57 patients with nontoxic nodular goiter were stimulated with either 0.3 mg recombinant human thyrotropin (rhTSH) or placebo before radioactive iodine 131I therapy. After one year the goiter reduction had improved by 35% compared to conventional 131I therapy. The difference was most pronounced in patients with a large goiter. Adverse effects, including development of permanent hypothyroidism, were significantly more frequent in the rhTSH group. Patient satisfaction was high and uninfluenced by the use of rhTSH.
authors.affiliation: Odense Universitetshospital, Endokrinologisk og Nuklearmedicinsk Afdeling, Odense C. viveque.egsgaard@ouh.fyns-amt.dk
authors.forename: Viveque Egsgaard
authors.initials: VE
authors.lastname: Nielsen
authors.forename: Steen Joop
authors.initials: SJ
authors.lastname: Bonnema
authors.forename: Henrik Boel
authors.initials: HB
authors.lastname: Jørgensen
authors.forename: Peter
authors.initials: P
authors.lastname: Grupe
authors.forename: Laszlo
authors.initials: L
authors.lastname: Hegedüs