Growth hormone signalling: sprouting links between pathways, human genetics and therapeutic options.
Our molecular understanding of growth hormone-induced signal transduction has improved significantly over the past decades. At the same time, human population genetics and the analysis of genetically engineered animals have led to the discovery of genes that control specific aspects of the overall growth process. Although, currently, growth disorders are still diagnosed and treated on empirical bases, it might soon be possible to stratify patients predominantly by genetic defect, with treatment based on our molecular understanding of the role of the affected gene in the disease.
Pilecka
Iwona
I
Serono Pharmaceutical Research Institute, 14, Chemin des Aulx, 1228 Plan-les-Ouates, Geneva, Switzerland.
Whatmore
Andrew
A
Hooft van Huijsduijnen
Rob
R
Destenaves
Benoit
B
Clayton
Peter
P
D000818:Animals; D006130:Growth Disorders / Q000235:genetics* / Q000628:therapy*; D013006:Growth Hormone / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D011986:Receptors, Somatotropin / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*
D011986:Receptors, Somatotropin; D013006:Growth Hormone