Perioperative evaluation of bleeding diathesis.
The differential diagnosis of a long APTT with a normal prothrombin time can be due to either a clotting factor deficiency or the presence of an inhibitor, which can be distinguished by using a plasma-mixing study. The various clotting factor deficiency states are reviewed. Clinical bleeding following cardiac bypass surgery due to acquired factor V and thrombin antibodies is also reviewed.
Leung
Lawrence L K
LL
VA Palo Alto HCS, Medical Service, B2-125, 3801 Miranda Ave., Palo Alto, CA 94304, USA. lawrence.leung@stanford.edu
D000906:Antibodies / Q000097:blood; D001778:Blood Coagulation Disorders / Q000209:etiology; D001780:Blood Coagulation Tests; D006348:Cardiac Surgical Procedures / Q000009:adverse effects*; D005165:Factor V / Q000276:immunology; D006470:Hemorrhage / Q000209:etiology; D006474:Hemorrhagic Disorders / Q000175:diagnosis* / Q000209:etiology*; D006801:Humans; D013917:Thrombin / Q000276:immunology
D000906:Antibodies; D005165:Factor V; D013917:Thrombin