title: Normal spirometry, gas transfer and lung volume values in Papua, Indonesia.
abstract: Spirometry is an efficient and clinically useful tool in the diagnosis and management of chronic lung disease. It relies on an appreciation of normal lung function that can vary between populations. In order to improve the utility of spirometry, gas transfer and lung volume measures for clinical and research use in Papua, Indonesia, we determined lung function in Papuan and non-Papuan Indonesian adults who did not have evidence of lung disease. A cross-sectional survey of Papuan and non-Papuan Indonesians 18 years or older with no history of chronic cough or recent wheeze was made. Spirometry, gas transfer and total lung capacity (TLC) were determined and regression models developed for normal values. The spirometry values were similar but not directly comparable to similar studies in Papua New Guinea populations. Papuan highland residents demonstrated independently greater values of gas transfer and total lung capacity in comparison to lowland Papuans. Values for lung function in apparent respiratory health were shown to differ between Papuan and non-Papuan Indonesian populations and in comparison to reference values derived from non-indonesian populations. Differences in age-related decline in lung function would suggest that simple proportional correction based on values derived from non-Indonesian populations may be inappropriate and would support the development of similar reference values in other populations. Whether differences seen here are innate or occur as a consequence of in-utero and post-partum environmental exposure remains to be accurately elucidated.
authors.affiliation: National Institute of Health Research and Development- Menzies School of Health Research, Timika Research Program, Mitra Masyrakat Hospital, Timika, Papua, Indonesia.
authors.forename: Tjandra
authors.initials: T
authors.lastname: Handojo
authors.forename: Nicholas
authors.initials: N
authors.lastname: Anstey
authors.forename: Paul
authors.initials: P
authors.lastname: Kelly
authors.forename: Michael
authors.initials: M
authors.lastname: Pain
authors.forename: Enny
authors.initials: E
authors.lastname: Kenangalem
authors.forename: Emiliana
authors.initials: E
authors.lastname: Tjitra
authors.forename: Graeme
authors.initials: G
authors.lastname: Maguire
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007214:Indonesia; D008176:Lung Volume Measurements; D008297:Male; D011659:Pulmonary Gas Exchange; D012016:Reference Values; D013147:Spirometry