Pleiotropic effects of the non-calcium phosphate binder sevelamer.
The number of chronic kidney disease (CKD) patients and related adverse outcomes has dramatically increased worldwide in the past decade. Therefore, numerous experimental and clinical studies have recently addressed the underlying mechanisms, in particular the marked increase in cardiovascular mortality. Hyperphosphatemia is a major problem in these patients with advanced stage of CKD. Its control by calcium-containing phosphate binders is effective, but at the price of potentially noxious calcium overload. Sevelamer hydrochloride is a phosphate binder that offers an effective control of hyperphosphatemia as calcium-rich binders but without increase of calcium load. Beyond the control of phosphate, sevelamer seems to exert pleiotropic effects which include the correction of lipid abnormalities and the clearance of some uremic toxins.
Nikolov
I G
IG
Inserm Unit 507, Necker Hospital, University of Paris V, Paris, France.
Joki
N
N
Maizel
J
J
Lacour
B
B
Drüeke
T B
TB
Massy
Z A
ZA
D002614:Chelating Agents / Q000627:therapeutic use*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000150:complications* / Q000276:immunology; D010710:Phosphates / Q000097:blood*; D010760:Phosphorus Metabolism Disorders / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D011073:Polyamines / Q000627:therapeutic use*; D000069603:Sevelamer; D014511:Uremia / Q000097:blood / Q000150:complications / Q000276:immunology
D002614:Chelating Agents; D010710:Phosphates; D011073:Polyamines; D000069603:Sevelamer