title: Modest copper supplementation blocks molybdenosis in cattle.
abstract: It is widely accepted that ratios of dietary copper (Cu) to molybdenum (Mo) lower than 10:1 may produce molybdenosis in cattle, especially if sulfur concentrations are more than 3,000 ppm. Some authorities suggest that dietary Mo concentrations greater than 10 ppm are hazardous to cattle regardless of Cu concentration, but anecdotal reports suggest that this may not be the case. The original purpose of the experiment described in this report was to investigate whether supranutritional supplemental Cu could protect cattle against relatively high dietary Mo. Pregnant cows were grazed on 1 of 3 pastures: 1 with only background Mo, 1 with an average of 13 ppm Mo, and 1 that averaged 230 ppm Mo. Half the cows on the Mo pastures were supplemented with 17 ppm dietary Cu, the other half with the dietary supplement plus Cu boluses. Molybdenum effects were anticipated in the groups supplemented with 17 ppm Cu; however, despite increased tissue concentrations of Mo, only the 230 ppm Mo/17 ppm Cu group exhibited any effects. Moderate Cu supplementation permitted cows to graze a site heavily contaminated with Mo with no adverse effects on general health or reproduction.
authors.affiliation: Department of Veterinary Sciences, University of Wyoming, Laramie, WY, USA.
authors.forename: Merl F
authors.initials: MF
authors.lastname: Raisbeck
authors.forename: Roger S
authors.initials: RS
authors.lastname: Siemion
authors.forename: Michael A
authors.initials: MA
authors.lastname: Smith
mesh_terms: D000704:Analysis of Variance; D000821:Animal Feed; D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000139:chemically induced / Q000378:metabolism / Q000517:prevention & control*; D003300:Copper / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics; D005260:Female; D008099:Liver / Q000378:metabolism; D008297:Male; D008982:Molybdenum / Q000097:blood / Q000493:pharmacokinetics / Q000506:poisoning*; D011041:Poisoning / Q000517:prevention & control / Q000662:veterinary; D011247:Pregnancy; D011248:Pregnancy Complications / Q000139:chemically induced / Q000517:prevention & control / Q000662:veterinary*; D011897:Random Allocation; D014018:Tissue Distribution / Q000187:drug effects
chemical_list: D003300:Copper; D008982:Molybdenum