title: Asymmetric construction of quaternary carbon stereocenter by Pd-catalyzed intramolecular alpha-arylation.
abstract: The catalyst comprised of Pd(OAc)(2) and H(8)-BINAP provides good reaction conversions for a catalytic enantioselective intramolecular alpha-arylation of N-(2-bromophenyl)-N-methyl-2-arylpropanamide to form the quaternary carbon with up to 68% enantioselectivity.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Nagoya City University.
authors.forename: Takafumi
authors.initials: T
authors.lastname: Arao
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Kondo
authors.forename: Toyohiko
authors.initials: T
authors.lastname: Aoyama
mesh_terms: D002384:Catalysis; D006571:Heterocyclic Compounds / Q000138:chemical synthesis*; D015394:Molecular Structure; D009281:Naphthalenes / Q000737:chemistry; D010165:Palladium / Q000737:chemistry*
chemical_list: C406943:BINAP, 2-naphthol; D006571:Heterocyclic Compounds; D009281:Naphthalenes; D010165:Palladium