title: Postradiation sarcoma of the chest wall: report of two cases.
abstract: Postradiation sarcoma is a rare late complication of external radiotherapy. We herein present two cases with this disease. A 54-year-old man had undergone a lobectomy and chest wall resection for Pancoast type lung cancer 7 years previously. He had undergone irradiation with a total dose of 50 Gy. Computed tomography (CT) demonstrated a tumorous expansion of the right lateral thoracic wall. A pathological examination confirmed a diagnosis of osteosarcoma. A 60-year-old woman had undergone a resection of the lateral chest wall mass, which was diagnosed to be Hodgkin's disease in 1991. Chemotherapy was given postoperatively. A tumorous lesion arose again and irradiation was performed with a total dose of 110 Gy. In 2000, two tumors appeared in the irradiation field. A pathological examination showed a sarcoma with divergent differentiation. In 2003, a tumor recurred and was diagnosed to be a liposarcoma. Patients who have received radiotherapy should therefore be followed up while taking into consideration the possible development of postradiation sarcoma.
authors.affiliation: Second Department of Surgery, Fukuoka University School of Medicine, Fukuoka, Japan.
authors.forename: Hironori
authors.initials: H
authors.lastname: Ninomiya
authors.forename: Tatsu
authors.initials: T
authors.lastname: Miyoshi
authors.forename: Takayuki
authors.initials: T
authors.lastname: Shirakusa
authors.forename: Takeshi
authors.initials: T
authors.lastname: Shiraishi
authors.forename: Nobuharu
authors.initials: N
authors.lastname: Yamamoto
authors.forename: Kazuki
authors.initials: K
authors.lastname: Nabeshima
mesh_terms: D044963:Biopsy, Fine-Needle; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D006689:Hodgkin Disease / Q000532:radiotherapy; D006801:Humans; D008175:Lung Neoplasms / Q000532:radiotherapy; D008297:Male; D008875:Middle Aged; D009381:Neoplasms, Radiation-Induced / Q000175:diagnosis / Q000209:etiology*; D012509:Sarcoma / Q000175:diagnosis / Q000209:etiology*; D013899:Thoracic Neoplasms / Q000175:diagnosis / Q000209:etiology*; D035441:Thoracic Wall / Q000528:radiation effects*; D014057:Tomography, X-Ray Computed