Late onset of severe graft-versus-host disease following liver transplantation.
Graft versus host disease (GVHD) is an uncommon but lethal complication following liver transplantation that results from the engraftment of T lymphocytes associated with the liver graft. It usually occurs 2 to 6 weeks after the procedure. We herein report a case of late onset of severe GVHD 4 months after cadaveric liver transplantation for hepatocellular carcinoma in a 54-year-old woman, which was characterized by refractory diarrhea and abdominal pain. Moreover we discuss risk factors of GVHD including the recipient age and cytomegalovirus (CMV) infection.
Sun
Beicheng
B
National Institute of Living Donor Liver Transplantation, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, Jiangsu 210029, P.R. China. sunbc@njmu.edu.cn
Zhao
Chaochen
C
Xia
Yongxiang
Y
Li
Guoqiang
G
Cheng
Feng
F
Li
Jun
J
Zhang
Feng
F
Wang
Xuehao
X
D015746:Abdominal Pain / Q000209:etiology; D003586:Cytomegalovirus Infections / Q000150:complications; D016172:DNA Fingerprinting; D017809:Fatal Outcome; D005260:Female; D005767:Gastrointestinal Diseases / Q000209:etiology; D006084:Graft Rejection / Q000517:prevention & control; D006086:Graft vs Host Disease / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D016031:Liver Transplantation / Q000009:adverse effects*; D008875:Middle Aged; D012307:Risk Factors; D013997:Time Factors
D007166:Immunosuppressive Agents