title: Contribution of class III MHC to susceptibility to type 1 diabetes in the NOD mouse.
abstract: A recombinant major histocompatibility complex (MHC) with the same class III region as the NOD mouse, but different class II region from the NOD mouse was identified in the NON mouse, and NOD mice congenic for this recombinant MHC, NOD.NON-H2, was established. None of the congenic mice homozygous for the NON MHC developed type 1 diabetes, indicating that the NOD MHC is necessary for the development of type 1 diabetes. A small portion of MHC heterozygotes developed late-onset type 1 diabetes, suggesting the contribution of class III MHC to type 1 diabetes susceptibility.
authors.affiliation: Department of Endocrinology, Metabolism and Diabetes, Kinki University School of Medicine, 377-2 Ohno-higashi, Osaka-Sayama, Osaka 589-8511, Japan.
authors.forename: Kaori
authors.initials: K
authors.lastname: Yamaji
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ikegami
authors.forename: Tomomi
authors.initials: T
authors.lastname: Fujisawa
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Noso
authors.forename: Koji
authors.initials: K
authors.lastname: Nojima
authors.forename: Naru
authors.initials: N
authors.lastname: Babaya
authors.forename: Michiko
authors.initials: M
authors.lastname: Itoi-Babaya
authors.forename: Misato
authors.initials: M
authors.lastname: Kobayashi
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Hiromine
authors.forename: Susumu
authors.initials: S
authors.lastname: Makino
authors.forename: Toshio
authors.initials: T
authors.lastname: Ogihara
mesh_terms: D000818:Animals; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006720:Homozygote; D008285:Major Histocompatibility Complex / Q000235:genetics*; D051379:Mice; D020297:Mice, Congenic; D016688:Mice, Inbred NOD