title: [Epidemiology of pediatric HIV infection in six provinces of China].
abstract: OBJECTIVE
  To investigate the epidemiology of pediatric human immunodeficiency virus (HIV) infection in six provinces of China.
  
  
  METHODS
  A cross-sectional study was conducted in six provinces with the highest HIV prevalence. Surveys on demographics and HIV-related questions (transmission modes, time of diagnosis, clinical stage, laboratory test) were distributed to clinicians in these provinces. Descriptive and bivariate analyses were performed on the completed surveys.
  
  
  RESULTS
  Survey results of 650 children [405 males and 245 females; average age: (7.9 +/- 3.2) years] were eligible for analysis. The interval between possible transmission and diagnosis was (7.1 +/- 3.2) years. The location distribution was as follows: 570 cases (87.7%) in Henan Province, 23 cases (3.5%) in Guangxi Province, 21 cases (3.2%) in Yunnan Province, 19 cases (2.9%) in Hubei Province, 10 cases (1.5%) in Anhui Province, and 7 cases (1.1%) in Shanxi Province. Transmission routes included mother-to-child transmission (75.1%), blood transfusion/ plasma donation (15.7 %), and injecting drug use (IDU, 0.5%). Former plasma donation (FPD) was the main transmission route in some provinces (Henan, Shanxi, Hubei, and Anhui), while IDU was the main transmission route in other provinces (Guangxi and Yunnan). The average age in the FPD provinces was significantly higher than that in IDU provinces [(8.1 +/- 3.2) vs. (5.4 +/- 2.2) years, P <0.001]. Among 178 patients in all six provinces who required treatment (on the basis of CD4 count or WHO staging), 133 (74.7%) did not receive treatment and 45 (25.3%) received antiretroviral therapy.
  
  
  CONCLUSIONS
  Mother-to-child transmission is the main transmission mode in pediatric patients. Efforts should be made to strengthen the diagnosis and treatment of pediatric HIV/AIDS patients.
authors.affiliation: Division of Treatment and Care, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhao
authors.forename: Wan-shen
authors.initials: WS
authors.lastname: Guo
authors.forename: Man-hong
authors.initials: MH
authors.lastname: Jia
authors.forename: Xiao-chun
authors.initials: XC
authors.lastname: Qiao
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.forename: Xuan
authors.initials: X
authors.lastname: Yao
authors.forename: Chuan-tao
authors.initials: CT
authors.lastname: Li
authors.forename: Zhi-hui
authors.initials: ZH
authors.lastname: Dou
authors.forename: Zai-cun
authors.initials: ZC
authors.lastname: Li
authors.forename: Ning
authors.initials: N
authors.lastname: Wang
authors.forename: Fu-jie
authors.initials: FJ
authors.lastname: Zhang
mesh_terms: D002648:Child; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D003430:Cross-Sectional Studies; D005260:Female; D015658:HIV Infections / Q000175:diagnosis / Q000453:epidemiology* / Q000628:therapy / Q000635:transmission*; D006801:Humans; D007223:Infant; D018445:Infectious Disease Transmission, Vertical; D008297:Male; D016485:Needle Sharing / Q000009:adverse effects; D065227:Transfusion Reaction