title: Experimental and numerical investigation into leakage effect in injectors of microfluidic devices.
abstract: This paper performs an experimental and numerical investigation into low-leakage injectors designed for electrophoresis microchips. The principal material transport mechanisms of electrokinetic migration, fluid flow, and diffusion are considered in developing a mathematical model of the electrophoresis process. Low-leakage injectors designed with injection channels orientated at various included angles are designed and tested. The numerical and experimental results indicate that the injector with a 30 degrees included angle successfully minimizes sample leakage and has an exciting potential for use in high-quality, high-throughput chemical analysis procedures and in many other applications in the field of micro-total analysis systems.
authors.affiliation: Department of Vehicle Engineering, National Pingtung University of Science and Technology, Pingtung, Taiwan.
authors.forename: Chien-Hsiung
authors.initials: CH
authors.lastname: Tsai
authors.forename: Yao-Nan
authors.initials: YN
authors.lastname: Wang
authors.forename: Chiu-Feng
authors.initials: CF
authors.lastname: Lin
authors.forename: Ruey-Jen
authors.initials: RJ
authors.lastname: Yang
authors.forename: Lung-Ming
authors.initials: LM
authors.lastname: Fu
mesh_terms: D003198:Computer Simulation; D046209:Electrophoresis, Microchip / Q000295:instrumentation*; D017022:Flow Injection Analysis / Q000295:instrumentation*; D046210:Microfluidic Analytical Techniques; D008956:Models, Chemical