A systematic review on drug interactions in oncology.
OBJECTIVE
To systematically review drug interactions in oncology.


METHODS
We searched PubMed for eligible articles and online databases abstracts of major oncology meetings from 2002 to 2005.


RESULTS
One study reported on the frequency of drug interactions. Interactions between chemotherapy and nonchemotherapy agents have been reported mostly in small clinical trials and case series. Interactions between chemotherapic agents have been reported mostly in Phase I studies. Few studies described fatal outcomes of drug interactions in cancer patients.


CONCLUSIONS
Drug interactions comprise an important issue in oncology, but very limited data exist on their frequency and clinical consequences.
Riechelmann
Rachel P
RP
Department of Medical Oncology and Hematology, Princess Margaret Hospital, Toronto, Canada. Rachel.Riechelmann@uhn.on.ca
Saad
Everardo D
ED
D000970:Antineoplastic Agents / Q000627:therapeutic use*; D017321:Clinical Trials, Phase I as Topic; D004347:Drug Interactions; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy*
D000970:Antineoplastic Agents