title: Type 2 diabetes and weight loss following biliopancreatic diversion for obesity.
abstract: BACKGROUND
  The authors investigated the weight loss and maintenance in type 2 diabetic obese patients undergoing biliopancreatic diversion (BPD).
  
  
  METHODS
  Two series of diabetic and non-diabetic obese patients matched for gender, age and baseline body mass index (BMI) were evaluated prior to BPD, on the occasion of the regular follow-up visit at 1, 2 and 3 years following the operation, and at the fifth postoperative year. At each follow-up point, body weight (BW), BMI, and serum glucose concentration were measured.
  
  
  RESULTS
  In all type 2 diabetic patients, the serum glucose level fell to within the normal range at the first postoperative year and remained within normal limits without any medication throughout all the follow-up period. In preoperatively diabetic subjects, mean values of BW and BMI were closely similar to those of non-diabetic subjects at all follow-up points, and the stabilization weight was independently related to age and to initial BW values.
  
  
  CONCLUSIONS
  In obese patients with type 2 diabetes, the glucose level steadily normalized in every case following BPD, and values remained unchanged throughout the follow-up period. After the operation, the type 2 diabetic obese patients experienced the same stable weight reduction as their non-diabetic counterparts.
authors.affiliation: Dipartimento di Discipline Chirurgiche, Facoltà di Medicina e Chirurgia, Università di Genova, Genova, Italy.
authors.forename: Giuseppe M
authors.initials: GM
authors.lastname: Marinari
authors.forename: Francesco S
authors.initials: FS
authors.lastname: Papadia
authors.forename: Lucia
authors.initials: L
authors.lastname: Briatore
authors.forename: Gianfranco
authors.initials: G
authors.lastname: Adami
authors.forename: Nicola
authors.initials: N
authors.lastname: Scopinaro
mesh_terms: D000293:Adolescent; D000328:Adult; D015904:Biliopancreatic Diversion; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications* / Q000517:prevention & control; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000150:complications* / Q000601:surgery*; D016896:Treatment Outcome; D015431:Weight Loss
chemical_list: D001786:Blood Glucose