title: Prism adaptation first among equals in alleviating left neglect: a review.
abstract: OBJECTIVE
  The current paper was designed to provide a critical overview on the different methods proposed for the rehabilitation of left spatial neglect.
  
  
  METHODS
  On the basis of a previous systematic review of the literature, we analyzed all articles available aiming at reducing left spatial neglect which included a long term functional assessment.
  
  
  RESULTS
  The aim of most early rehabilitation approaches, such as visuo-scanning training, was to re-orient visual scanning toward the neglected side. This review confirmed the utility of this method for rehabilitation purposes. More recent - theory driven - procedures, also based on a training approach, include limb activation, mental imagery training and video-feedback training. Although there is ground for optimism, the functional effectiveness of these methods still relies on few single-case studies. Newer methods have tried to stimulate automatic orientation of gaze or attention towards neglected space in a bottom-up fashion. Sensory stimulations can remove most of the classical signs of left neglect but their effects are short-lived. Such stimulations are not functionally relevant for rehabilitation except for trunk rotation or repeated neck muscle vibrations if they are associated with an extensive training program. A more promising intervention is prism adaptation given the growing evidence of relatively long-term functional gains from comparatively short term usage.
  
  
  CONCLUSIONS
  Overall, there is now evidence for several clinically relevant long-term benefits in the case of visual scanning training, mental imagery training, video feedback training, neck muscle vibration and trunk rotation if associated with visual scanning training and prism adaptation. However, the amount of evidence is still limited to a small number of relevant published articles and it is mandatory to continue the research in this field. In this review, the possible routes for new rehabilitation procedures are discussed on the basis of the actual knowledge regarding the neuro-cognitive mechanisms underlying the therapeutic effect of prism adaptation.
authors.affiliation: Hospices Civils de Lyon, Hôpital Henry Gabrielle, Service de Rééducation Neurologique, Saint Genis Laval, France. jacques.luaute@chu-lyon.fr
authors.forename: Jacques
authors.initials: J
authors.lastname: Luauté
authors.forename: Peter
authors.initials: P
authors.lastname: Halligan
authors.forename: Gilles
authors.initials: G
authors.lastname: Rode
authors.forename: Sophie
authors.initials: S
authors.lastname: Jacquin-Courtois
authors.forename: Dominique
authors.initials: D
authors.lastname: Boisson
mesh_terms: D000222:Adaptation, Physiological / Q000502:physiology*; D005121:Extremities / Q000502:physiology; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D007092:Imagination; D010468:Perceptual Disorders / Q000534:rehabilitation*; D010775:Photic Stimulation; D012677:Sensation / Q000502:physiology