Intrauterine exposures, pregnancy estrogens and breast cancer risk: where do we currently stand?
Since 1990, when a hypothesis on intrauterine influences on breast cancer risk was published, several studies have provided supportive, indirect evidence by documenting associations of birth weight and other correlates of the prenatal environment with breast cancer risk in offspring. Recent results from a unique cohort of women with documented exposure to diethylstilbestrol in utero have provided direct evidence in support of a potential role of pregnancy oestrogens on breast cancer risk in offspring.
Lagiou
Pagona
P
Department of Hygiene and Epidemiology, University of Athens Medical School, 75 M, Asias Street, Goudi, GR-115 27, Athens, Greece. pdlagiou@med.uoa.gr
D001943:Breast Neoplasms / Q000209:etiology*; D004967:Estrogens; D005260:Female; D006801:Humans; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D012306:Risk
D004967:Estrogens