title: Nail involvement in langerhans cell histiocytosis.
abstract: Nail involvement, which is distinctly uncommon in Langerhans cell histiocytosis (LCH), is characterized by various features like longitudinal grooving, purpuric striae, hyperkeratosis, subungual pustules, deformity, loss of nail plate, paronychia, onycholysis, and pitting. Here the authors report the case of a child who presented with isolated nail unit changes due to Langerhans cell histiocytosis before the evolution of systemic features. The authors suggest that LCH should be considered in differential diagnoses of nail changes that are resistant to therapy.
authors.affiliation: Bahrami Children Hospital, Tehran University of Medical Sciences, Tehran, Iran. Zashena@gmail.com
authors.forename: Zahra
authors.initials: Z
authors.lastname: Ashena
authors.forename: Samin
authors.initials: S
authors.lastname: Alavi
authors.forename: Mohammad Taghi
authors.initials: MT
authors.lastname: Arzanian
authors.forename: Peyman
authors.initials: P
authors.lastname: Eshghi
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002675:Child, Preschool; D005260:Female; D006646:Histiocytosis, Langerhans-Cell / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D009260:Nail Diseases / Q000209:etiology*