title: Antimalarial activity of concanamycin A alone and in combination with pyronaridine.
abstract: Concanamycin A, a macrolide antibiotic inhibitor of vacuolar H+-ATPase derived from Streptomyces sp, inhibited Plasmodium falciparum K1 growth in culture with an IC500 value of 0.2 nM. It exhibited an additive effect when tested together with the antimalarial pyronaridine.
authors.affiliation: Division of Toxicology, Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand. rasao@mahidol.ac.th
authors.forename: Saranya
authors.initials: S
authors.lastname: Auparakkitanon
authors.forename: Prapon
authors.initials: P
authors.lastname: Wilairat
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000633:toxicity*; D020128:Inhibitory Concentration 50; D018942:Macrolides / Q000633:toxicity*; D009287:Naphthyridines / Q000633:toxicity*; D010963:Plasmodium falciparum / Q000187:drug effects*
chemical_list: D000962:Antimalarials; D018942:Macrolides; D009287:Naphthyridines; C036978:concanamycin A; C027871:pyronaridine