title: Injectable bone substitute to preserve alveolar ridge resorption after tooth extraction: a study in dog.
abstract: The aim of the present study was to assess the efficacy of a ready-to-use injectable bone substitute on the prevention of alveolar ridge resorption after tooth extraction. Maxillary and mandibular premolars were extracted from 3 Beagle dogs with preservation of alveolar bone. Thereafter, distal sockets were filled with an injectable bone substitute (IBS), obtained by combining a polymer solution and granules of a biphasic calcium phosphate (BCP) ceramic. As a control, the mesial sockets were left unfilled. After a 3 months healing period, specimens were removed and prepared for histomorphometric evaluation with image analysis. Histomorphometric study allowed to measure the mean and the maximal heights of alveolar crest modifications. Results always showed an alveolar bone resorption in unfilled sockets. Resorption in filled maxillary sites was significantly lower than in control sites. Interestingly, an alveolar ridge augmentation was measured in mandibular filled sockets including 30% of newly-formed bone. It was concluded that an injectable bone substitute composed of a polymeric carrier and calcium phosphate can significantly increase alveolar ridge preservation after tooth extraction.
authors.affiliation: INSERM, U791, Laboratoire dingénierie Ostéo-articulaire et dentaire, LIOAD, 1 place A. Ricordeau, Nantes, F-44042, France.
authors.forename: D
authors.initials: D
authors.lastname: Boix
authors.forename: P
authors.initials: P
authors.lastname: Weiss
authors.forename: O
authors.initials: O
authors.lastname: Gauthier
authors.forename: J
authors.initials: J
authors.lastname: Guicheux
authors.forename: J-M
authors.initials: JM
authors.lastname: Bouler
authors.forename: P
authors.initials: P
authors.lastname: Pilet
authors.forename: G
authors.initials: G
authors.lastname: Daculsi
authors.forename: G
authors.initials: G
authors.lastname: Grimandi
mesh_terms: D000539:Alveolar Process / Q000502:physiology*; D000818:Animals; D001862:Bone Resorption / Q000503:physiopathology / Q000517:prevention & control*; D018786:Bone Substitutes / Q000008:administration & dosage*; D004285:Dogs; D007267:Injections; D014081:Tooth Extraction; D014945:Wound Healing / Q000502:physiology*
chemical_list: D018786:Bone Substitutes