title: Isolation and structure of four new ceramides from the starfish Luidia maculata.
abstract: A new sphingosine-type ceramide LMCer-1-1 (1) and three new phytosphingosine-type ceramides, LMCer-2-1 (2), LMCer-2-6 (3), and LMCer-2-7 (4), were isolated from the anti-hyperglycemic active ceramide molecular species LMCer-1 and LMCer-2, obtained from the less polar fraction of the chloroform-methanol extract of the whole bodies of Luidia maculata. The structures of these ceramides were determined on the basis of chemical and spectroscopic evidence as: (2S,3R,4E,2'R)-2-(2-hydroxyhexadecanoylamino)-16-methyl-4-octadecene-1,3-diol (1), (2S,3S,4R,2'R)-2-(2-hydroxyhexadecanoylamino)-16-methyl-octadecane-1,3,4-triol (2), (2S,3S,4R,2'R)-2-(2-hydroxydocosanoylamino)-hexadecane-1,3,4-triol (3), and (2S,3S,4R,2'R)-2-(2-hydroxydocosanoylamino)-14-methyl-hexadecane-1,3,4-triol (4).
authors.affiliation: Faculty of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.
authors.forename: Masanori
authors.initials: M
authors.lastname: Inagaki
authors.forename: Yuriko
authors.initials: Y
authors.lastname: Ikeda
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kawatake
authors.forename: Kazufumi
authors.initials: K
authors.lastname: Nakamura
authors.forename: Miyuki
authors.initials: M
authors.lastname: Tanaka
authors.forename: Eriko
authors.initials: E
authors.lastname: Misawa
authors.forename: Muneo
authors.initials: M
authors.lastname: Yamada
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Higuchi
mesh_terms: D000818:Animals; D002518:Ceramides / Q000737:chemistry*; D015394:Molecular Structure; D013215:Starfish / Q000737:chemistry*
chemical_list: D002518:Ceramides