Aminolevulinic acid photodynamic therapy for sebaceous gland hyperplasia.
Current therapies for sebaceous hyperplasia (SH) have a high risk for adverse effects and recurrence of treated lesions. The theoretic basis for the treatment of SH by photodynamic therapy (PDT) with 5-aminolevulinic acid (ALA) has been established. Studies show that 1 hour is sufficient ALA incubation time to achieve clearance, and ALA-induced protoporphyrin IX may be activated with a 585-nm pulsed dye laser device, blue light source, or an intense pulsed light device. Complete clearance may be achieved with one to six treatments; however, long-term recurrence rates are not established. ALA PDT is a safe and effective modality for the treatment of SH lesions of all sizes.
Richey
Donald F
DF
North Valley Dermatology Center, 251 Cohasset Road, Suite 240, Chico, CA 95926, USA. drichey132@aol.com
D000622:Aminolevulinic Acid / Q000627:therapeutic use*; D005148:Facial Dermatoses / Q000188:drug therapy*; D006801:Humans; D006965:Hyperplasia; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000627:therapeutic use*; D012625:Sebaceous Gland Diseases / Q000188:drug therapy*
D017319:Photosensitizing Agents; D000622:Aminolevulinic Acid