title: [Antifungal and phagocytic immunostimulation treatment of chronic disseminated dermatophytosis].
abstract: A 39 years old man with a long-standing disseminated dermatophytosis even with several antifungal treatments is presented. From lesions, Trichophyton rubrum var. typical downy, T. tonsurans and Candida albicans were isolated and showed sensivity to azolic compounds in vitro. The phagocytic activity in vitro compared with normal control was depressed. Treatment with itraconazole and immunomodulation using a bacterial antigen was indicated. During the last two years the patient has been clinical and mycologically healthy, and his phagocytosis activity has become normal. In patients with chronic and relapsing dermatophytosis, the immune response evaluation is recommended, and immunomodulation could be useful as a rational measure in patients with a particular immunodeficiency.
authors.affiliation: Servicio de Dermatología y Micología Mèdica, UMAE Hospital de Especialidades "Dr. Bernardo Sepúlveda", IMSS. México D. F., México. liserja@hotmail.com
authors.forename: Liliana
authors.initials: L
authors.lastname: Serrano-Jaén
authors.forename: Luis J
authors.initials: LJ
authors.lastname: Méndez-Tovar
authors.forename: Víctor
authors.initials: V
authors.lastname: Almeida-Arvizu
authors.forename: Patricia
authors.initials: P
authors.lastname: Manzano-Gayosso
authors.forename: Erika
authors.initials: E
authors.lastname: Córdova-Martínez
authors.forename: Elva
authors.initials: E
authors.lastname: Bazán-Mora
authors.forename: Francisca
authors.initials: F
authors.lastname: Hernández-Hernández
authors.forename: Rubén
authors.initials: R
authors.lastname: López-Martínez
mesh_terms: D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use*; D003881:Dermatomycoses / Q000188:drug therapy* / Q000276:immunology; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D008297:Male; D016896:Treatment Outcome
chemical_list: D000935:Antifungal Agents