[Clinical study on colonic transmission time and the effect of sini powder on it in functional constipation patients].
OBJECTIVE
To investigate the characteristic of colonic transmission in functional constipation (FC) and the effect of traditional Chinese medicine (TCM) Sini Powder (SP) on it.


METHODS
The colonic transmission time (CTT) of 36 patients with FC (the FC group) and 22 healthy subjects (control group) was measured through colonic transmission test, and CTT of entire colon and that of various subsections was calculated with Hinton method and Arhan method respectively. After then, the FC group was treated with SP for 7 days, and CTT was detected again after treatment.


RESULTS
Before treatment, body mass index (BMI) was higher, CTT of entire colon, left half colonic section, and sigmoid-rectal section were longer in the FC group than those in the control group (P < 0.05), no statistical difference in CTT of right half colon was found between the two groups (P > 0.05). After FC patients being treated with SP, their CTT of whole colon, left half colonic section and sigmoid-rectal section were significantly shortened (P < 0.05).


CONCLUSIONS
FC patients were characterized by increased BMI and CTT prolonged and unevenly distributed in subsections, especially in the left half colon, sigmoid and rectum; SP could shorten the CTT in FC patients.
Jin
Zhao-hui
ZH
jxjzh@126.com
Duan
Jian-hua
JH
Zhao
Hong-chuan
HC
D000328:Adult; D015992:Body Mass Index; D003106:Colon / Q000187:drug effects / Q000503:physiopathology; D012809:Colon, Sigmoid / Q000187:drug effects / Q000503:physiopathology; D003248:Constipation / Q000188:drug therapy* / Q000503:physiopathology*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D005772:Gastrointestinal Transit / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy; D013997:Time Factors; D016896:Treatment Outcome
D004365:Drugs, Chinese Herbal; C478756:sini tang