[The effect of topical application of 5-fluorouracil on patency times after incisional myringotomy of guinea pig tympanic membrane].
OBJECTIVE
We investigated the effect of topical application of 5-fluorouracil after incisional myringotomy on the patency time and its use as an alternative to ventilation tube insertion.


METHODS
Experimental tympanic membrane perforations were induced in two groups of guinea pigs. One group (20 tympanic membranes) was treated with a 50 mg/ml 5-fluorouracil-soaked sponge over the perforation for five minutes while the other (16 tympanic membranes) with saline-soaked sponges for the same duration. The patency times, otorrhea, and other complications were recorded.


RESULTS
The mean patency of tympanic membrane perforations following incisional myringotomy was significantly longer in the 5-fluorouracil-treated group (11.3 days vs 7.0 days; p<0.01). None of the ears exhibited permanent perforation.


CONCLUSIONS
The length of patency provided by 5-fluorouracil is not sufficient for optimal ventilation time in otitis media with effusion. However, in circumstances in which shorter patency times may provide sufficient ventilation, 5-fluorouracil application may be an alternative to ventilation tube insertion.
Eken
Mehmet
M
Department of Otolaryngology, Dr. Lütfi Kirdar Training and Research Hospital, Istanbul, Turkey. memedeken@yahoo.com
Evren
Cenk
C
Ateş
Günay
G
Bozkurt
Ziya
Z
Sanli
Arif
A
Aydin
Sedat
S
D000287:Administration, Topical; D000818:Animals; D000963:Antimetabolites / Q000008:administration & dosage*; D004195:Disease Models, Animal; D005472:Fluorouracil / Q000008:administration & dosage*; D006168:Guinea Pigs; D008876:Middle Ear Ventilation; D014432:Tympanic Membrane / Q000187:drug effects; D018058:Tympanic Membrane Perforation / Q000188:drug therapy* / Q000473:pathology
D000963:Antimetabolites; D005472:Fluorouracil