title: Canine renal cortical necrosis and haemorrhage following ingestion of an Amitraz-formulated insecticide dip.
abstract: Amitraz is a formamidine compound used in veterinary medicine as a topical dip to control ticks and mites on dogs and livestock. A 10-year-old female Scottish terrier was presented following the accidental oral administration of a dip containing amitraz. This case report describes the clinical signs, treatment and pathology of this dog. Clinical signs of toxicity from amitraz result from stimulation of alpha2-adrenergic receptors. Amitraz is seldom fatal because the effects can be reversed by alpha2-adrenergic antagonists. The dog recovered from the amitraz toxicity but died 5 days later from acute renal failure.
authors.affiliation: Fourways Veterinary Hospital, PO Box 68159, Bryanston, 2021 South Africa.
authors.forename: P A
authors.initials: PA
authors.lastname: Oglesby
authors.forename: K E
authors.initials: KE
authors.lastname: Joubert
authors.forename: T
authors.initials: T
authors.lastname: Meiring
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced / Q000209:etiology / Q000473:pathology / Q000662:veterinary*; D000818:Animals; D004283:Dog Diseases / Q000139:chemically induced* / Q000209:etiology / Q000473:pathology; D004285:Dogs; D017809:Fatal Outcome; D005260:Female; D007306:Insecticides / Q000037:antagonists & inhibitors / Q000633:toxicity*; D011041:Poisoning / Q000150:complications / Q000188:drug therapy / Q000662:veterinary*; D014052:Toluidines / Q000037:antagonists & inhibitors / Q000633:toxicity*
chemical_list: D007306:Insecticides; D014052:Toluidines; C014983:amitraz