Synthesis of loliolide, actinidiolide, dihydroactinidiolide, and aeginetolide via cerium enolate chemistry.
Loliolide, aeginetolide, actinidiolide, and dihydroactinidiolide were synthesized in racemic form from a single common intermediate, prepared through the 1,2 addition of the cerium enolate of ethyl acetate to 2,6,6-trimethylcylohexenone.
Eidman
Kirk F
KF
Firmenich, Princeton, New Jersey 08543, USA. kirk.eidman@firmenich.com
MacDougall
Brian S
BS
D002338:Carotenoids / Q000138:chemical synthesis* / Q000737:chemistry; D002563:Cerium / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy
D002563:Cerium; D002338:Carotenoids