A new antifungal macrolide, eushearilide, isolated from Eupenicillium shearii.
In screening for antifungal substances, a new macrolide, eushearilide (1), was isolated from Eupenicillium shearii IFM54447. The structure of 1 was established to be 24-membered macrolide having a non-conjugated diene and a choline phosphate ester moetiy on the basis of detailed investigation of NMR, UV, IR and MS spectral data. Compound 1 showed antifungal activity against various fungi and yeasts, including human pathogens Aspergillus fumigatus, Trichophyton spp. and Candida spp.
Hosoe
Tomoo
T
Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41, Shinagawa-ku, Tokyo 142-8501, Japan. hosoe@hoshi.ac.jp
Fukushima
Kazutaka
K
Takizawa
Kayoko
K
Itabashi
Takeshi
T
Kawahara
Nobuo
N
Vidotto
Valerio
V
Kawai
Ken-Ichi
K
D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001232:Aspergillus fumigatus / Q000187:drug effects; D002175:Candida / Q000187:drug effects; D032641:Eurotiales / Q000378:metabolism*; D018942:Macrolides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010767:Phosphorylcholine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D013057:Spectrum Analysis; D014249:Trichophyton / Q000187:drug effects
D000935:Antifungal Agents; D018942:Macrolides; C515840:eushearilide; D010767:Phosphorylcholine