G protein signaling in yeast: new components, new connections, new compartments.
Signaling by cell surface receptors and heterotrimeric guanine nucleotide-binding proteins (G proteins) is one of the most exhaustively studied processes in the cell but remains a major focus of molecular pharmacology research. The pheromone-response system in yeast (see the Connections Map at Science's Signal Transduction Knowledge Environment) has provided numerous major advances in our understanding of G protein signaling and regulation. However, the basic features of this prototypical pathway have remained largely unchanged since the mid-1990s. New tools available in yeast are beginning to uncover new pathway components and interactions and have revealed signaling in unexpected locations within the cell.
Slessareva
Janna E
JE
Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC 27599-7260, USA.
Dohlman
Henrik G
HG
D002462:Cell Membrane / Q000378:metabolism*; D056827:Endosomal Sorting Complexes Required for Transport; D011992:Endosomes / Q000378:metabolism*; D044385:GTP-Binding Protein alpha Subunits / Q000378:metabolism; D043802:GTP-Binding Protein alpha Subunits, Gq-G11; D044387:GTP-Binding Protein beta Subunits / Q000378:metabolism; D044388:GTP-Binding Protein gamma Subunits / Q000378:metabolism; D020690:GTPase-Activating Proteins; D020962:Heterotrimeric GTP-Binding Proteins / Q000378:metabolism*; D007425:Intracellular Membranes / Q000378:metabolism; D008954:Models, Biological; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism; D020710:RGS Proteins / Q000378:metabolism; D051964:Receptors, Mating Factor / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism*; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism; D015398:Signal Transduction; D058571:Vacuolar Sorting Protein VPS15
D056827:Endosomal Sorting Complexes Required for Transport; D044385:GTP-Binding Protein alpha Subunits; D043802:GTP-Binding Protein alpha Subunits, Gq-G11; D044387:GTP-Binding Protein beta Subunits; D044388:GTP-Binding Protein gamma Subunits; D020690:GTPase-Activating Proteins; D020962:Heterotrimeric GTP-Binding Proteins; D019869:Phosphatidylinositol 3-Kinases; D017346:Protein Serine-Threonine Kinases; D020710:RGS Proteins; D051964:Receptors, Mating Factor; D029701:Saccharomyces cerevisiae Proteins; D058571:Vacuolar Sorting Protein VPS15; C094301:SST2 protein, S cerevisiae; C084294:STE18 protein, S cerevisiae; C498031:STE2 protein, S cerevisiae; C067576:Ste4 protein, S cerevisiae; C546854:VPS15 protein, S cerevisiae; C084293:GPA1 protein, S cerevisiae