Re-evaluating cell-cycle regulation by E2Fs.
Activation of E2F transcription factors is thought to drive the expression of genes essential for the transition of cells from G1 to S phase and for the initiation of DNA replication. However, this textbook view of E2Fs is increasingly under challenge. Here we discuss an alternative model for how E2Fs may work.
Rowland
Benjamin D
BD
Division of Molecular Carcinogenesis and Center of Biomedical Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.
Bernards
René
R
D000818:Animals; D002453:Cell Cycle; D050684:E2F Transcription Factors / Q000737:chemistry / Q000378:metabolism*; D008957:Models, Genetic; D017434:Protein Structure, Tertiary; D012097:Repressor Proteins / Q000378:metabolism; D015533:Transcriptional Activation
D050684:E2F Transcription Factors; D012097:Repressor Proteins