Extreme thrombocytosis under the treatment by amoxicillin/clavulanate.
Amoxicillin/Clavulanate related extreme thrombocytosis during the treatment of pneumonia has never been reported. We present a 54-year-old patient who was admitted due to pneumonia, and was treated with amoxicillin/clavulanate IV and 3-day course of 500 mg azithromycin. Despite clinical and radiological evidence showing that pneumonia improved, thrombocytes increased rapidly. After stopping the antibiotic, the thrombocytes returned gradually to normal. Considering the clinical course, we propose that this extreme thrombocytosis was caused by the administration of amoxicillin/clavulanate. We describe this rare and unique patient and review the literature.
Yang
Chih-Jen
CJ
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, 807, Taiwan.
Hwang
Jhi-Jhu
JJ
Hung
Jen-Yu
JY
Chong
Inn-Wen
IW
Huang
Ming-Shyan
MS
D000658:Amoxicillin / Q000009:adverse effects* / Q000627:therapeutic use*; D019818:Clavulanic Acid / Q000009:adverse effects* / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D006801:Humans; D008875:Middle Aged; D011014:Pneumonia / Q000188:drug therapy / Q000473:pathology; D013922:Thrombocytosis / Q000139:chemically induced* / Q000473:pathology*
D019818:Clavulanic Acid; D000658:Amoxicillin