p16(INK4a) promoter hypermethylation in oral scrapings of oral squamous cell carcinoma risk patients.
Aberrant promoter hypermethylation is common in oral squamous cell carcinoma (OSCC) and may be useful as a marker for cancer cells. The aim of our study was to assess whether the detection of hypermethylation of the promoter region of p16(INK4a) in oral cytological samples could be a marker in patients with risk of developing an OSCC. Hypermethylation was detected in 20% (29/145) of the cases analyzed. These findings provide further evidence that the inactivation of p16(INK4a), due to methylation, is an early event in the carcinogenic pathway of OSCC.
Ruesga
María Teresa
MT
Oral Medicine and Pathology, University of the Basque Country EHU, Vizcaya, Spain.
Acha-Sagredo
Amelia
A
Rodríguez
María José
MJ
Aguirregaviria
José Ignacio
JI
Videgain
Juan
J
Rodríguez
Carlos
C
de Pancorbo
María de los Angeles Martínez
Mde L
Aguirre
José Manuel
JM
D000368:Aged; D000369:Aged, 80 and over; D000428:Alcohol Drinking; D014408:Biomarkers, Tumor / Q000032:analysis; D002294:Carcinoma, Squamous Cell / Q000235:genetics; D019175:DNA Methylation; D005260:Female; D019942:Genes, p16; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa / Q000166:cytology; D009062:Mouth Neoplasms / Q000235:genetics*; D011230:Precancerous Conditions / Q000235:genetics; D011401:Promoter Regions, Genetic; D012306:Risk; D012907:Smoking
D014408:Biomarkers, Tumor