Modafinil and cocaine interactions.
This Phase I trial evaluated the interaction between modafinil steady-state and cocaine. Twelve non-treatment seeking, cocaine dependent volunteers received four sets of randomized blinded infusions of saline, 20 mg IV cocaine, and 40 mg IV cocaine. Modafinil was given open label at 0 mg, 400 mg, or 800 mg. Modafinil combined with IV cocaine did not result in any significant hemodynamic interactions. Modafinil significantly dampened scores on Visual Analog Scale measures as compared to baseline cocaine conditions. No significant alterations in labs occurred. Further outpatient trials of modafinil appear to be warranted.
Malcolm
Robert
R
Center for Drug and Alcohol Programs, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA. malcolmr@musc.edu
Swayngim
Karla
K
Donovan
Jennifer L
JL
DeVane
C Lindsay
CL
Elkashef
Ahmed
A
Chiang
Nora
N
Khan
Roberta
R
Mojsiak
Jurij
J
Myrick
Donald L
DL
Hedden
Sarra
S
Cochran
Kristi
K
Woolson
Robert F
RF
D001559:Benzhydryl Compounds / Q000008:administration & dosage / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D003042:Cocaine / Q000008:administration & dosage; D019970:Cocaine-Related Disorders / Q000188:drug therapy*; D004347:Drug Interactions; D006801:Humans; D007262:Infusions, Intravenous; D000077408:Modafinil; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D012449:Safety; D016896:Treatment Outcome
D001559:Benzhydryl Compounds; D018696:Neuroprotective Agents; D003042:Cocaine; D000077408:Modafinil