title: [Effect of Passiflora edulis (passion fruit) extract on rats' bladder wound healing: morphological study].
abstract: OBJECTIVE
  To evaluate the effects of hydroalcoholic extract of Passiflora edulis leaves in the healing of urinary bladder in rats from histological aspects.
  
  
  METHODS
  Forty Wistar male rats were submitted to a longitudinal incision of the bladder followed by a stetching in only one level. After this common procedure, animals were divided at random two groups: Passiflora and Control. In the Passiflora group the only dosage used was administered by intraperitoneal injection of hydroalcoholic extract of Passiflora edulis leaves while in the Control group distilled water was injected. Each subgroup was then divided in two subgroups according to the death of these animals: Control, three and seven days, Passiflora, three and seven days. After the death of these animals, an inventory of the abdominal cavity was performed and the bladder was removed. A comparative analysis was done between the two groups with microscopic evaluation of the healing. There was less acute inflammation (p=0.008), greater collagenous formation (p=0.001) and greater capillary neo-formation (p=0.000) in the third day Passiflora subgroup when compared to the Control subgroup of the third day.
  
  
  RESULTS
  There was less acute inflammation (p=0.001), greater fibroblastic proliferation (p=0.011) and greater collagenous formation (p=0.001) in the Passiflora subgroup of seventh day when compared with the Control seventh day subgroup.
  
  
  CONCLUSIONS
  The use of Passiflora edulis leaves extract resulted in less acute inflammation, greater fibroblastic proliferation, collagenous formation and capillary neo-formation on rats' bladder wound healing.
authors.affiliation: Departamento de Cirurgia, Universidade Federal do Maranhao. antoniouro@oi.com.br
authors.forename: Antonio
authors.initials: A
authors.lastname: Gonçalves Filho
authors.forename: Orlando Jorge Martins
authors.initials: OJ
authors.lastname: Torres
authors.forename: Antonio Carlos Ligocki
authors.initials: AC
authors.lastname: Campos
authors.forename: Renato
authors.initials: R
authors.lastname: Tâmbara Filho
authors.forename: Luiz Carlos de Almeida
authors.initials: LC
authors.lastname: Rocha
authors.forename: Arnulf
authors.initials: A
authors.lastname: Thiede
authors.forename: Sandra Maria Corrêa
authors.initials: SM
authors.lastname: Lunedo
authors.forename: Raimundo Eri de Araújo
authors.initials: RE
authors.lastname: Barbosa
authors.forename: Joel Antonio
authors.initials: JA
authors.lastname: Bernhardt
authors.forename: Paulo Roberto Leitão de
authors.initials: PR
authors.lastname: Vasconcelos
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use*; D003094:Collagen / Q000187:drug effects; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D007274:Injections, Intraperitoneal; D008297:Male; D029598:Passiflora / Q000737:chemistry*; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use; D018515:Plant Leaves / Q000737:chemistry; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors; D001743:Urinary Bladder / Q000187:drug effects / Q000293:injuries* / Q000648:ultrastructure; D014945:Wound Healing / Q000187:drug effects* / Q000502:physiology
chemical_list: D000893:Anti-Inflammatory Agents; D010936:Plant Extracts; D003094:Collagen