title: Altered venous capacitance as a cause of postprandial hypotension in multiple system atrophy.
abstract: Patients with multiple system atrophy (MSA) often have clinically significant postprandial hypotension (PPH). To elucidate the cause of insufficient cardiac preload augmentation that underlies PPH, we recorded calf venous capacitance (CVC) by strain-gauge plethysmography, in 17 MSA patients and eight healthy controls before and after oral glucose ingestion. Among 17 MSA patients, nine who showed a decrease in systolic blood pressure exceeding 20 mmHg and were diagnosed with PPH. MSA patients without PPH showed a significant decrease in CVC and a significant increase in cardiac output after oral glucose ingestion, as did controls; those with MSA exhibiting PPH showed a significant increase in CVC and no significant change in cardiac output. The change in CVC correlated positively with the decrease in systolic and diastolic blood pressure after glucose ingestion, and also correlated negatively with the increase in cardiac output. Physiologically, PPH is prevented by a decrease in venous capacitance, which increases circulating blood volume and cardiac output. In some MSA patients, failure of venous capacitance to decrease may induce PPH.
authors.affiliation: Dept of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
authors.forename: Motoko
authors.initials: M
authors.lastname: Takamori
authors.forename: Masaaki
authors.initials: M
authors.lastname: Hirayama
authors.forename: Rei
authors.initials: R
authors.lastname: Kobayashi
authors.forename: Hiroki
authors.initials: H
authors.lastname: Ito
authors.forename: Naoki
authors.initials: N
authors.lastname: Mabuchi
authors.forename: Tomohiko
authors.initials: T
authors.lastname: Nakamura
authors.forename: Norio
authors.initials: N
authors.lastname: Hori
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Koike
authors.forename: Gen
authors.initials: G
authors.lastname: Sobue
mesh_terms: D000368:Aged; D001127:Arginine Vasopressin / Q000097:blood / Q000502:physiology; D001341:Autonomic Nervous System / Q000503:physiopathology; D001794:Blood Pressure / Q000502:physiology; D003714:Denervation; D005260:Female; D005947:Glucose; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D007022:Hypotension / Q000209:etiology* / Q000503:physiopathology*; D007866:Leg / Q000098:blood supply; D008297:Male; D008875:Middle Aged; D019578:Multiple System Atrophy / Q000150:complications* / Q000503:physiopathology*; D009638:Norepinephrine / Q000097:blood / Q000502:physiology; D019518:Postprandial Period / Q000502:physiology*; D011187:Posture / Q000502:physiology; D012039:Regional Blood Flow / Q000502:physiology; D018924:Vascular Capacitance / Q000502:physiology*
chemical_list: D001127:Arginine Vasopressin; D005947:Glucose; D009638:Norepinephrine