title: An immunochemical approach to model and long-term suppression of depressive and anxiety behavior.
abstract: The inhibitor of monoaminooxydase isatin and the ligand of B-receptors cholecystokinin-4 play a significant role in the suppression and induction of depressive and anxiety states. We induced the formation of auto-antibodies to these compounds against their conjugates with antigen-carrier by immunization of white rats. The result was long-term (more than 2 months) stimulation of depressive and anxiety behavior after immunization to isatin and, in contrast, the suppression of such behavior after immunization to cholecystokinin. The perspective of immunochemical approach to long-term correction of behavior is discussed.
authors.affiliation: Dept. of Human Physiology, School of Biology, Moscow State University, Vorobiovy Gory, Moscow 119922, Russia. ashmarin25@mail.ru
authors.forename: Igor P
authors.initials: IP
authors.lastname: Ashmarin
authors.forename: Raisa A
authors.initials: RA
authors.lastname: Danilova
authors.forename: Olga I
authors.initials: OI
authors.lastname: Rud'ko
authors.forename: Maria V
authors.initials: MV
authors.lastname: Belopolskaya
authors.forename: Maria F
authors.initials: MF
authors.lastname: Obukhova
authors.forename: Elena V
authors.initials: EV
authors.lastname: Shmalgausen
mesh_terms: D000818:Animals; D001007:Anxiety / Q000276:immunology* / Q000628:therapy; D001323:Autoantibodies / Q000097:blood*; D003863:Depression / Q000276:immunology* / Q000628:therapy; D018796:Immunoconjugates / Q000276:immunology; D007510:Isatin / Q000276:immunology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013758:Tetragastrin / Q000276:immunology*; D014611:Vaccination
chemical_list: D001323:Autoantibodies; D018796:Immunoconjugates; D013758:Tetragastrin; D007510:Isatin