Combinatorial microscopy.
By taking advantage of combinations of the many rich properties of photons, new forms of optical microscopy can now be used to visualize features of samples beyond thickness and density variations. We are now within reach of viewing the motions, orientations, binding kinetics and specific transient associations of previously 'submicroscopic' cellular structures and single molecules.
Axelrod
Daniel
D
Department of Physics & Biophysics Research Division, University of Michigan, Ann Arbor, Michigan 48109, USA. daxelrod@umich.edu
Omann
Geneva M
GM
D000818:Animals; D036681:Fluorescence Recovery After Photobleaching; D031541:Fluorescence Resonance Energy Transfer; D006801:Humans; D008853:Microscopy / Q000295:instrumentation* / Q000379:methods*; D008856:Microscopy, Fluorescence; D009504:Neutrophils / Q000166:cytology; D017785:Photons; D012680:Sensitivity and Specificity; D020349:Surface Plasmon Resonance