title: Genetic linkage and horizontal gene transfer, the roots of the antibiotic multi-resistance problem.
abstract: Bacteria carrying resistance genes for many antibiotics are moving beyond the clinic into the community, infecting otherwise healthy people with untreatable and frequently fatal infections. This state of affairs makes it increasingly important that we understand the sources of this problem in terms of bacterial biology and ecology and also that we find some new targets for drugs that will help control this growing epidemic. This brief and eclectic review takes the perspective that we have too long thought about the problem in terms of treatment with or resistance to a single antibiotic at a time, assuming that dissemination of the resistance gene was affected by simple vertical inheritance. In reality antibiotic resistance genes are readily transferred horizontally, even to and from distantly related bacteria. The common agents of bacterial gene transfer are described and also one of the processes whereby nonantibiotic chemicals, specifically toxic metals, in the environment can select for and enrich bacteria with antibiotic multiresistance. Lastly, some speculation is offered on broadening our perspective on this problem to include drugs directed at compromising the ability of the mobile elements themselves to replicate, transfer, and recombine, that is, the three "infrastructure" processes central to the movement of genes among bacteria.
authors.affiliation: Department of Microbiology, University of Georgia, Athens, Georgia 30602, USA. summers@uga.edu
authors.forename: Anne O
authors.initials: AO
authors.lastname: Summers
mesh_terms: D000822:Animal Husbandry; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects* / Q000235:genetics*; D003227:Conjugation, Genetic; D004251:DNA Transposable Elements; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics*; D004783:Environmental Microbiology; D022761:Gene Transfer, Horizontal; D005798:Genes, Bacterial; D008040:Genetic Linkage; D006801:Humans; D032023:Integrons; D019216:Metals, Heavy / Q000633:toxicity; D014161:Transduction, Genetic
chemical_list: D000900:Anti-Bacterial Agents; D004251:DNA Transposable Elements; D019216:Metals, Heavy