title: Enriched environment treatment counteracts enhanced addictive and depressive-like behavior induced by prenatal chronic stress.
abstract: Prenatal stress can cause many long-term behavior changes in offspring, but whether prenatal stress can alter addictive behavior in offspring and postnatal enriched environment treatment (EE) can restore these changes are unknown. We reported here that prenatal chronic stress (10 unpredictable, 1 s, 0.8 mA foot-shocks per day during gestational days 13-19) enhanced morphine-induced (10 mg/kg, s.c., per day, 6 consecutive days) place preference. Moreover, prenatal chronic stress caused higher depressive-like behavior in forced swimming test in adult offspring. However, enriched environment housing treatment on postnatal days 22-52 counteracted both the abnormal behaviors alterations. This work observed a phenomenon that might contribute to the understanding of clinically important interactions among addiction, prenatal stress and enriched environment treatment. Postnatal enriched environment treatment might be an important therapeutic intervention in preventing the prenatal stress-induced addictive disorders.
authors.affiliation: Mental Health Institute, The 2nd Xiangya Hospital, Central South University, Changsha 410011, PR China.
authors.forename: Jianli
authors.initials: J
authors.lastname: Yang
authors.forename: Weihui
authors.initials: W
authors.lastname: Li
authors.forename: Xiaohua
authors.initials: X
authors.lastname: Liu
authors.forename: Zexuan
authors.initials: Z
authors.lastname: Li
authors.forename: Hongying
authors.initials: H
authors.lastname: Li
authors.forename: Guifu
authors.initials: G
authors.lastname: Yang
authors.forename: Lin
authors.initials: L
authors.lastname: Xu
authors.forename: Lingjiang
authors.initials: L
authors.lastname: Li
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D000831:Animals, Newborn; D016739:Behavior, Addictive / Q000209:etiology / Q000517:prevention & control*; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology; D003216:Conditioning, Operant / Q000187:drug effects / Q000502:physiology; D003866:Depressive Disorder / Q000209:etiology / Q000517:prevention & control*; D004777:Environment; D005260:Female; D008297:Male; D009020:Morphine / Q000008:administration & dosage; D009294:Narcotics / Q000008:administration & dosage; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000209:etiology* / Q000523:psychology*; D051381:Rats; D017208:Rats, Wistar; D013315:Stress, Psychological; D013550:Swimming
chemical_list: D009294:Narcotics; D009020:Morphine