Osteopontin: a novel inflammatory mediator of cardiovascular disease.
Osteopontin, also called cytokine Eta-1, is a multifunctional protein containing Arg-Gly-Asp-Ser (RGDS) cell-binding sequence. It interacts with alpha(v)beta1, alpha(v)beta3 and alpha(v)beta5 integrins and CD44 receptors. OPN is suggested to play a role during inflammation via the recruitment and retention of macrophages and T-cells to inflamed sites. OPN regulates the production of inflammatory cytokines and nitric oxide in macrophages. In this review, we will discuss diverse roles of OPN related to cardiovascular diseases, including atherosclerosis, valvular stenosis, hypertrophy, myocardial infarction and heart failure.
Singh
Mahipal
M
Department of Physiology, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA. singhm@etsu.edu
Ananthula
Srinivas
S
Milhorn
Denise M
DM
Krishnaswamy
Guha
G
Singh
Krishna
K
D000818:Animals; D002318:Cardiovascular Diseases / Q000175:diagnosis / Q000209:etiology* / Q000276:immunology; D006331:Heart Diseases / Q000209:etiology; D006801:Humans; D018836:Inflammation Mediators / Q000737:chemistry / Q000502:physiology; D053495:Osteopontin / Q000737:chemistry / Q000502:physiology*; D014652:Vascular Diseases / Q000209:etiology
D018836:Inflammation Mediators; D053495:Osteopontin