title: Multimodal treatment of metastatic colorectal cancer.
abstract: BACKGROUND
  Metastases to the liver is the leading cause of death in patients with colorectal cancer.
  
  
  METHODS
  The authors review the data on diagnosis and management of this clinical problem, and they discuss management options that can be considered.
  
  
  RESULTS
  Complete surgical resection of metastases from colorectal cancer that are localized to the liver results in 5-year survival rates ranging from 26% to 40%.
  
  
  CONCLUSIONS
  By adding modalities such as targeted systemic therapy and other "local" treatments for liver metastases, further gains in survival are anticipated.
authors.affiliation: University Clinic of Surgery, General Hospital of Vienna.
authors.forename: Irene
authors.initials: I
authors.lastname: Kuehrer
mesh_terms: D015179:Colorectal Neoplasms / Q000473:pathology*; D003131:Combined Modality Therapy; D006498:Hepatectomy; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary* / Q000628:therapy*; D020360:Neoadjuvant Therapy; D009364:Neoplasm Recurrence, Local