Extended longevity mechanisms in short-lived progeroid mice: identification of a preservative stress response associated with successful aging.
Semantic distinctions between "normal" aging, "pathological" aging (or age-related disease) and "premature" aging (otherwise known as segmental progeria) potentially confound important insights into the nature of each of the complex processes. Here we review a recent, unexpected discovery: the presence of longevity-associated characteristics typical of long-lived endocrine-mutant and dietary-restricted animals in short-lived progeroid mice. These data suggest that a subset of symptoms observed in premature aging, and possibly normal aging as well, may be indirect manifestations of a beneficial adaptive stress response to endogenous oxidative damage, rather than a detrimental result of the damage itself.
van de Ven
Marieke
M
Medical Genetics Center, Department of Cell Biology and Genetics, Center of Biomedical Genetics, P.O. Box 1738, Erasmus MC, 3000DR Rotterdam, The Netherlands.
Andressoo
Jaan-Olle
JO
Holcomb
Valerie B
VB
Hasty
Paul
P
Suh
Yousin
Y
van Steeg
Harry
H
Garinis
George A
GA
Hoeijmakers
Jan H J
JH
Mitchell
James R
JR
D000375:Aging / Q000502:physiology*; D000818:Animals; D004260:DNA Repair / Q000502:physiology; D008136:Longevity / Q000502:physiology*; D051379:Mice; D011371:Progeria / Q000503:physiopathology*; D013312:Stress, Physiological / Q000503:physiopathology*