Synthesis of a technetium-99m labeled tricyclic ganciclovir analog for non-invasive reporter gene expression imaging.
A potential radiopharmaceutical and HSV1-TK substrate, 3-((1,3-dihydroxypropan-2-yloxy)-methyl)-6-(4-(3-((2-mercaptoethyl)(2-(2-mercaptoethyl-amino)-ethyl)amino)propoxy)phenyl)-3H-imidazopurin-9(5H)-one-oxo-technetium(V), was synthesized via a converging approach and its chemical structure was comparatively characterized with a non-radioactive analog. The final radiochemical purity and yield were 97 and 73%, respectively.
Zhang
Yi
Y
The Department of Radiology, University of Virginia, Charlottesville, VA 22908, USA.
Lin
Jing
J
Pan
Dongfeng
D
D000963:Antimetabolites / Q000138:chemical synthesis*; D002851:Chromatography, High Pressure Liquid; D015774:Ganciclovir / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D015870:Gene Expression; D017930:Genes, Reporter / Q000235:genetics*; D018259:Herpesvirus 1, Human / Q000201:enzymology; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D015609:Organotechnetium Compounds / Q000138:chemical synthesis*; D019275:Radiopharmaceuticals / Q000138:chemical synthesis*; D013667:Technetium / Q000737:chemistry; D013937:Thymidine Kinase / Q000378:metabolism
C518527:3-((1,3-dihydroxypropan-2-yloxy)-methyl)-6-(4-(3-((2-mercaptoethyl)(2-(2-mercaptoethyl-amino)-ethyl)amino)propoxy)phenyl)-3H-imidazopurin-9(5H)-one-oxo-technetium(V); D000963:Antimetabolites; D007202:Indicators and Reagents; D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; D013667:Technetium; D013937:Thymidine Kinase; D015774:Ganciclovir