Immunopathogenesis of hepatitis B virus infection.
Hepatitis B virus (HBV) infection is a non-cytopathic hepatotropic virus that can lead to severe liver disease including acute hepatitis, cirrhosis and hepatocellular carcinoma. Successful clearance of the virus as well as the establishment of liver disease is largely driven by a complex interaction between the virus and the host immune response. In this review, the immunological events, including both the innate and adaptive immune response are discussed in the setting of both acute and chronic HBV infection and liver disease.
Chang
J Judy
JJ
Department of Microbiology and Immunology, University of Melbourne, Melbourne, Victoria, Australia.
Lewin
Sharon R
SR
D000208:Acute Disease; D017951:Antigen Presentation; D006509:Hepatitis B / Q000276:immunology* / Q000473:pathology / Q000628:therapy; D006513:Hepatitis B e Antigens / Q000276:immunology; D006515:Hepatitis B virus / Q000276:immunology / Q000472:pathogenicity; D019694:Hepatitis B, Chronic / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate; D018448:Models, Immunological; D013601:T-Lymphocytes / Q000276:immunology
D006513:Hepatitis B e Antigens