Recent advances in the development and application of microemulsion EKC.
Microemulsion EKC (MEEKC) is an electrodriven separation technique. Separations are typically achieved using oil-in-water microemulsions, which are composed of nanometre-sized oil droplets suspended in an aqueous buffer. The droplets are stabilised by a surfactant and a cosurfactant. The novel use of water-in-oil microemulsions has also been investigated. This review summarises the advances in the development of MEEKC separations and also the different areas of application including determination of log P values, pharmaceutical applications, chiral analysis, natural products and bioanalytical separations and the use of new methods such as multiplexed MEEKC and high speed MEEKC. Recent applications (2004-2006) are tabulated for each area with microemulsion composition details.
McEvoy
Eamon
E
Department of Chemical and Life Sciences, Waterford Institute of Technology, Cork Road, Waterford, Ireland. emcevoy@wit.ie
Marsh
Alex
A
Altria
Kevin
K
Donegan
Sheila
S
Power
Joe
J
D001688:Biological Products / Q000032:analysis; D002021:Buffers; D002626:Chemistry, Pharmaceutical; D020374:Chromatography, Micellar Electrokinetic Capillary / Q000379:methods*; D019075:Electrophoresis, Capillary / Q000379:methods; D004655:Emulsions; D005504:Food Analysis / Q000379:methods; D006863:Hydrogen-Ion Concentration; D044085:Microfluidics; D004364:Pharmaceutical Preparations / Q000737:chemistry; D013237:Stereoisomerism; D013501:Surface-Active Agents / Q000737:chemistry; D013696:Temperature
D001688:Biological Products; D002021:Buffers; D004655:Emulsions; D004364:Pharmaceutical Preparations; D013501:Surface-Active Agents