title: Ischemia and apoptosis in an animal model of permanent infarct-related artery occlusion.
abstract: Apoptosis is a pathologic feature of cardiomyocytes in acute myocardial infarction (AMI) and heart failure. The temporal course of apoptosis in the peri-infarct area in the weeks following an AMI is still uncompletely defined. In order to study the time course of apoptosis after AMI, 16 rabbits underwent left coronary artery ligation and were sacrificed at 16, 26, 35, and 56 days after surgery. Increased apoptotic rate (AR) was observed at in the peri-infarct region than in remote myocardium (5.4% [2.5-9.6] vs 0.4% [0.1-0.9], respectively, P<0.001) and than in sham-operated cases (0.01% [0-0.02], P<0.001). A gradual decrease of AR in the peri-infarct region was observed over time with a 90% reduction at 8 weeks after coronary ligation.
authors.forename: Antonio
authors.initials: A
authors.lastname: Abbate
authors.forename: Celina
authors.initials: C
authors.lastname: Morales
authors.forename: Maria
authors.initials: M
authors.lastname: De Falco
authors.forename: Valentina
authors.initials: V
authors.lastname: Fedele
authors.forename: Giuseppe G L
authors.initials: GG
authors.lastname: Biondi Zoccai
authors.forename: Daniele
authors.initials: D
authors.lastname: Santini
authors.forename: Jimena
authors.initials: J
authors.lastname: Palleiro
authors.forename: Fortunata
authors.initials: F
authors.lastname: Vasaturo
authors.forename: Susanna
authors.initials: S
authors.lastname: Scarpa
authors.forename: Giovanna
authors.initials: G
authors.lastname: Liuzzo
authors.forename: Anna
authors.initials: A
authors.lastname: Severino
authors.forename: Feliciano
authors.initials: F
authors.lastname: Baldi
authors.forename: Filippo
authors.initials: F
authors.lastname: Crea
authors.forename: Luigi M
authors.initials: LM
authors.lastname: Biasucci
authors.forename: George W
authors.initials: GW
authors.lastname: Vetrovec
authors.forename: Ricardo J
authors.initials: RJ
authors.lastname: Gelpi
authors.forename: Alfonso
authors.initials: A
authors.lastname: Baldi
mesh_terms: D000818:Animals; D017209:Apoptosis; D003327:Coronary Disease / Q000473:pathology*; D051546:Cyclooxygenase 2 / Q000378:metabolism; D004195:Disease Models, Animal; D005260:Female; D017202:Myocardial Ischemia / Q000473:pathology*; D009206:Myocardium / Q000473:pathology*; D032383:Myocytes, Cardiac / Q000378:metabolism / Q000473:pathology; D011817:Rabbits; D013997:Time Factors
chemical_list: D051546:Cyclooxygenase 2