From antigen processing to peptide-MHC binding.
Emil R. Unanue recounts his seminal work 25 years ago demonstrating that antigens are phagocytosed and processed by antigen-presenting cells and that class II major histocompatibility complex molecules are peptide-binding proteins.
Unanue
Emil R
ER
Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri 63110, USA. unanue@pathbox.wustl.edu
D000486:Allergy and Immunology / Q000266:history*; D000818:Animals; D017951:Antigen Presentation / Q000276:immunology*; D000938:Antigen-Presenting Cells / Q000276:immunology* / Q000378:metabolism; D000949:Histocompatibility Antigens Class II / Q000276:immunology* / Q000378:metabolism; D049673:History, 20th Century; D006801:Humans
D000949:Histocompatibility Antigens Class II