title: The gene for human IL-21 and genetic susceptibility to type 1 diabetes in the Japanese.
abstract: Type 1 diabetes is under polygenic control both in humans and the NOD mouse. Recently a possible role of IL-21 in the pathogenesis of type 1 diabetes was demonstrated in the NOD mouse. Furthermore, the murine IL-21 gene is mapped to the Idd3 interval, making the human IL-21 gene (IL21) a functional as well as positional candidate for susceptibility. We therefore screened sequence variants of IL21 and studied the association with type 1 diabetes. Preliminary data showed no association of IL21 polymorphisms with the disease, suggesting that IL21 plays little role in susceptibility to type 1 diabetes in Japanese.
authors.affiliation: Department of Endocrinology, Diabetes and Metabolism, Kinki University School of Medicine, 377-2 Ohno-higashi, Sayama, Osaka 589-8511, Japan.
authors.forename: Katsuaki
authors.initials: K
authors.lastname: Asano
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ikegami
authors.forename: Tomomi
authors.initials: T
authors.lastname: Fujisawa
authors.forename: Yumiko
authors.initials: Y
authors.lastname: Kawabata
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Noso
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Hiromine
authors.forename: Toshio
authors.initials: T
authors.lastname: Ogihara
mesh_terms: D000483:Alleles; D016022:Case-Control Studies; D030541:Databases, Genetic; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics*; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D006801:Humans; D007378:Interleukins / Q000235:genetics*; D007564:Japan / Q000453:epidemiology; D020641:Polymorphism, Single Nucleotide; D017422:Sequence Analysis, DNA; D000098546:Interleukin-21
chemical_list: D007378:Interleukins; D000098546:Interleukin-21