title: Age-related changes in myocardial nerve and collagen networks of the auricle of the right atrium.
abstract: OBJECTIVE
  The objective of this study was to analyse age-related changes in human myocardial nerve plexuses and collagen networks of the auricle of the right atrium in subjects in whom no cardiac diseases or pathology had been diagnosed.
  
  
  RESULTS
  Morphometric analysis of acetylcholinesterase (AChE)-stained nerve plexuses and picrosirius-stained cardiac collagen networks from 17 persons of both genders aged 20-94 years was performed using video microscopy and a digital video camera. It was found that with age linear regression of nerve plexuses occurred.Atrial collagen content increases lifelong.
  
  
  CONCLUSIONS
  Aging of human atrial myocardium is accompanied by a decrease of nerve plexuses and an increase in fibrosis.
authors.affiliation: Department of Human Anatomy, Kaunas University of Medicine, Lithuania.
authors.forename: Ausra
authors.initials: A
authors.lastname: Burkauskiene
authors.forename: Zygmunt
authors.initials: Z
authors.lastname: Mackiewicz
authors.forename: Ismo
authors.initials: I
authors.lastname: Virtanen
authors.forename: Yrjö T
authors.initials: YT
authors.lastname: Konttinen
mesh_terms: D000110:Acetylcholinesterase; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D017776:Autonomic Pathways / Q000378:metabolism / Q000473:pathology / Q000648:ultrastructure*; D003094:Collagen / Q000378:metabolism / Q000648:ultrastructure*; D005260:Female; D006325:Heart Atria / Q000294:innervation / Q000378:metabolism / Q000473:pathology / Q000648:ultrastructure; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism / Q000473:pathology / Q000648:ultrastructure*; D009412:Nerve Fibers / Q000378:metabolism / Q000473:pathology / Q000648:ultrastructure; D013194:Staining and Labeling
chemical_list: D003094:Collagen; D000110:Acetylcholinesterase