The recent evolution of pentachlorophenol (PCP)-4-monooxygenase (PcpB) and associated pathways for bacterial degradation of PCP.
Man-made polychlorinated phenols such as pentachlorophenol (PCP) have been used extensively since the 1920s as preservatives to prevent fungal attack on wood. During this time, they have become serious environmental contaminants. Despite the recent introduction of PCP in the environment on an evolutionary time scale, PCP-degrading bacteria are present in soils worldwide. The initial enzyme in the PCP catabolic pathway of numerous sphingomonads, PCP-4-monooxygenase (PcpB), catalyzes the para-hydroxylation of PCP to tetrachlorohydroquinone and is encoded by the pcpB gene. This review examines the literature concerning pcpB and supports the suggestion that pcpB/PcpB should be considered a model system for the study of recent evolution of catabolic pathways among bacteria that degrade xenobiotic molecules introduced into the environment during the recent past.
Crawford
Ronald L
RL
Environmental Biotechnology Institute, Food Research Center 202, University of Idaho, Moscow, ID 83844-1052, USA. crawford@uidaho.edu
Jung
Carina M
CM
Strap
Janice L
JL
D001426:Bacterial Proteins / Q000378:metabolism; D001673:Biodegradation, Environmental; D005075:Biological Evolution; D002384:Catalysis; D003001:Cloning, Molecular; D004777:Environment; D018014:Gene Transfer Techniques; D006900:Hydroxylation; D006899:Mixed Function Oxygenases / Q000235:genetics* / Q000502:physiology*; D008956:Models, Chemical; D008957:Models, Genetic; D010416:Pentachlorophenol / Q000378:metabolism*; D010802:Phylogeny; D020578:Sphingomonas / Q000378:metabolism; D015262:Xenobiotics / Q000737:chemistry
D001426:Bacterial Proteins; D015262:Xenobiotics; D010416:Pentachlorophenol; D006899:Mixed Function Oxygenases; C069781:pentachlorophenol monooxygenase