Effect of substituents on diarylmethanes for antitubercular activity.
Aminoalkyl derivatives of diarylmethanes were prepared using Grignard, Friedel-Crafts arylation and aminohydrochloride chain formation reactions. These series of compounds were evaluated against Mycobacterium tuberculosis H(37)R(v) and showed the activity in the range of 6.25-25 microg/mL. Effect of heteroaryl, anthracenyl and phenanthrene groups on diarylmethane pharmacophores for antitubercular activity is described.
Panda
Gautam
G
Medicinal and Process Chemistry Division, Central Drug Research Institute, Chattar Manzil Palace, Lucknow-226001, UP, India. gautam_panda@lycos.com
Parai
Maloy Kumar
MK
Das
Sajal Kumar
SK
Shagufta
Sinha
Manish
M
Chaturvedi
Vinita
V
Srivastava
Anil K
AK
Manju
Y S
YS
Gaikwad
Anil N
AN
Sinha
Sudhir
S
D000818:Animals; D000995:Antitubercular Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002522:Chlorocebus aethiops; D004354:Drug Screening Assays, Antitumor; D007202:Indicators and Reagents; D008264:Macrophages / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008697:Methane / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology*; D051379:Mice; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D013055:Spectrophotometry, Infrared; D013329:Structure-Activity Relationship; D014709:Vero Cells
D000995:Antitubercular Agents; D007202:Indicators and Reagents; D008697:Methane