title: [Healing process in bladder suture of rats with and without the administration of intraperitoneal Jatropha gossypiifolia L. gross extract].
abstract: BACKGROUND
  The suture of tissues and their healing process is one of the basic fundamentals of surgery, and the research on substances which could improve the process is an ongoing challenge. The use of plants has been tested but till nowadays without scientific demonstration.
  
  
  OBJECTIVE
  To compare the macroscopic and histological alterations done by the use of intraperitoneal Jatropha gossypiifolia L. gross extract, in the healing process of sutures performed on the bladder of rats.
  
  
  METHODS
  Forty adult, male, Wistar rats were distributed into two animal groups. One centimeter longitudinal incision on the bladder ventral wall, and single plane synthesis with separated polyglactine 910 5-0 (Ethicon) stitches was done in all the animals. In the control group an intraperitoneal cavity instillation of distilled water at a ratio of 1 ml/kg/weight, and a 1 ml/kg/weight of Jatropha gossypiifolia L. extract for the Jatropha group was done representing 200 mg of the substance. Each group was subdivided into two with 10 animals in each, being submitted to euthanasia on 3rd and 7th post-operative days. Comparative histological, macroscopic and statistical analysis were undertaken between the subgroups.
  
  
  RESULTS
  Statistical significant difference was observed in the acute inflammation changes, vascular neoformation and bonding on day 3; the first one was greater in the control group, and the latter two greater in the Jatropha group; acute inflammation variables and fibroblastic proliferation presented to be more intense on day 7, with statistical significance favoring the control group.
  
  
  CONCLUSIONS
  No favorable healing effect was observed with the administration of single intraperitoneal dose of Jatropha gossypiifolia L. gross extract on the sutures of bladder in rats.
authors.affiliation: Departamento de Cirurgia, Universidade Federal do Maranhao.
authors.forename: José Maria Ayres
authors.initials: JM
authors.lastname: Maia
authors.forename: Nicolau Gregori
authors.initials: NG
authors.lastname: Czeczko
authors.forename: Jurandir Marcondes
authors.initials: JM
authors.lastname: Ribas Filho
authors.forename: Ulrich Andreas
authors.initials: UA
authors.lastname: Dietz
authors.forename: Danielle
authors.initials: D
authors.lastname: Duck
authors.forename: Carmen Australia Paredes Marcondes
authors.initials: CA
authors.lastname: Ribas
authors.forename: Eduardo Andrade dos
authors.initials: EA
authors.lastname: Santos
authors.forename: Eduardo
authors.initials: E
authors.lastname: Baptistella
authors.forename: Tatiana Zacharow
authors.initials: TZ
authors.lastname: Wallbach
authors.forename: José de Ribamar
authors.initials: Jde R
authors.lastname: Vale
authors.forename: Nelson
authors.initials: N
authors.lastname: Yagushita
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D007249:Inflammation / Q000188:drug therapy / Q000473:pathology; D007274:Injections, Intraperitoneal; D031286:Jatropha / Q000737:chemistry*; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use; D018515:Plant Leaves / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D013536:Suture Techniques; D013997:Time Factors; D001743:Urinary Bladder / Q000601:surgery* / Q000648:ultrastructure; D014945:Wound Healing / Q000187:drug effects* / Q000502:physiology
chemical_list: D000893:Anti-Inflammatory Agents; D010936:Plant Extracts