title: Diagnostic pitfalls associated with fine-needle aspiration biopsy in a patient with the myxoid variant of monophasic fibrous synovial sarcoma.
abstract: Synovial sarcoma (SS) is one of the most common soft tissue tumors that typically presents in the extremities of young adults, but may occur at any site and affect children during the first decade. Herein we discuss a 12-yr-old male who complained of left foot pain and plantar mass. A fine-needle aspiration biopsy of an 8 cm subcutaneous mass was performed revealing a myxoid spindle cell neoplasm. The cytologic differential diagnosis included a myxoid neurofibroma, neurothekeoma, and a myxoid sarcoma. Subsequent excision of the mass revealed a monophasic fibrous SS with myxoid features. Examination of the tissue by fluorescence in situ hybridization confirmed the presence of characteristic SS SYT gene rearrangement at chromosome 18q11.2. This case underscores that the cytologic distinction of mxyoid spindle cell tumors may be challenging. We report the cytologic features of a myxoid monophasic fibrous SS, and discuss its distinction from other benign and malignant myxoid soft tissue neoplasms.
authors.affiliation: Department of Pathology, Wake Forest University Health Sciences, Winston-Salem, NC 27157, USA. sbergman@wfubmc.edu
authors.forename: Simon
authors.initials: S
authors.lastname: Bergman
authors.forename: Noel A
authors.initials: NA
authors.lastname: Brownlee
authors.forename: Kim R
authors.initials: KR
authors.lastname: Geisinger
authors.forename: William G
authors.initials: WG
authors.lastname: Ward
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Pettenati
authors.forename: Patrick
authors.initials: P
authors.lastname: Koty
authors.forename: Ezra
authors.initials: E
authors.lastname: Ellis
authors.forename: Michael W
authors.initials: MW
authors.lastname: Beaty
authors.forename: Scott E
authors.initials: SE
authors.lastname: Kilpatrick
mesh_terms: D044963:Biopsy, Fine-Needle; D002648:Child; D005528:Foot / Q000000981:diagnostic imaging; D045888:Ganglion Cysts / Q000473:pathology*; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008279:Magnetic Resonance Imaging; D008297:Male; D011859:Radiography; D013584:Sarcoma, Synovial / Q000175:diagnosis* / Q000473:pathology*