title: Systemic lupus erythematosus and renal involvement: which role of citokines expression?
abstract: The role of cytokines in systemic lupus erythematosus (SLE) glomerulonephritis is extremely complex. Proinflammatory molecules, such as TNF, IL-6, IL-1 and IL-18 are upregulated, as are both Thl and Th2 cytokines, with different implications: the local effects may be different from the systemic immunoregulatory ones. Excessive T helper cell function is a hallmark of SLE and abnormalities of Th citokine profiles have been implicated in loss of immune tolerance, increased antogenic load, defective B cell suppression and a variety of clinical manifestations. For some cytokines, TNF and IL-18 in particular, the local proinflammatory ones may be more relevant to the disease.
authors.affiliation: Department of Medicina Clinica, University of Rome La Sapienza, Rome, Italy. antonietta_gigante@yahoo.it
authors.forename: A
authors.initials: A
authors.lastname: Gigante
authors.forename: D
authors.initials: D
authors.lastname: Amoroso
authors.forename: F
authors.initials: F
authors.lastname: Ferri
authors.forename: C
authors.initials: C
authors.lastname: Gianni
authors.forename: G
authors.initials: G
authors.lastname: Coppolino
authors.forename: A
authors.initials: A
authors.lastname: Papa
authors.forename: A
authors.initials: A
authors.lastname: Amoroso
mesh_terms: D016207:Cytokines / Q000096:biosynthesis*; D006801:Humans; D007674:Kidney Diseases / Q000191:economics* / Q000378:metabolism*; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000378:metabolism*
chemical_list: D016207:Cytokines