Enzymatically triggered self-assembly of poly(ethylene glycol)-attached oligopeptides into well-organized nanofibers.
A unique and programmable peptide self-assembling system has been fabricated by using poly(ethylene glycol)-attached amphiphilic oligopeptide, which shows rapid self-assembly into well-organized beta-sheet nanofibers in response to an enzymatic reaction.
Koga
Tomoyuki
T
Department of Molecular Science & Technology, Faculty of Engineering, Doshisha University, Kyotanabe, Kyoto, 610-0321, Japan. nhigashi@mail.doshisha.ac.jp.
Kitamura
Ken-ichi
K
Higashi
Nobuyuki
N
D004789:Enzyme Activation; D018625:Microscopy, Atomic Force / Q000379:methods; D049329:Nanostructures / Q000737:chemistry*; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry*; D012680:Sensitivity and Specificity; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / Q000379:methods; D013917:Thrombin / Q000737:chemistry*
D009842:Oligopeptides; D011092:Polyethylene Glycols; D013917:Thrombin