A new small-molecule Stat3 inhibitor.
In this issue of Chemistry & Biology, Schust et al. report the discovery of a small molecule (Stattic) that inhibits the binding of a high affinity phosphopeptide for the SH2 domain of Stat3. Stattic is a new tool for studying Stat3 signaling and demonstrates that the SH2 domain is not a dead target.
McMurray
John S
JS
Department of Experimental Therapeutics, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 36, Houston, Texas 77030, USA.
D003499:Cyclic S-Oxides / Q000378:metabolism*; D010748:Phosphopeptides / Q000037:antagonists & inhibitors / Q000378:metabolism; D011485:Protein Binding; D050796:STAT3 Transcription Factor / Q000037:antagonists & inhibitors* / Q000378:metabolism; D018909:src Homology Domains
D003499:Cyclic S-Oxides; D010748:Phosphopeptides; D050796:STAT3 Transcription Factor; C517409:stattic