title: Normal sleep and circadian rhythms: neurobiologic mechanisms underlying sleep and wakefulness.
abstract: Sleep is a vital, highly organized process regulated by complex systems of neuronal networks and neurotransmitters. Sleep plays an important role in the regulation of central nervous system and body physiologic functions. Sleep architecture changes with age and is easily susceptible to external and internal disruption. Reduction or disruption of sleep can affect numerous functions varying from thermoregulation to learning and memory during the waking state.
authors.affiliation: Department of Psychiatry and Human Behavior, Thomas Jefferson University, Philadelphia, PA 19107-5004, USA. dimitri.markov@jefferson.edu
authors.forename: Dimitri
authors.initials: D
authors.lastname: Markov
authors.forename: Marina
authors.initials: M
authors.lastname: Goldman
mesh_terms: D000109:Acetylcholine / Q000502:physiology; D000367:Age Factors; D001833:Body Temperature Regulation / Q000502:physiology; D001921:Brain / Q000502:physiology*; D002940:Circadian Rhythm / Q000502:physiology*; D004325:Dreams; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D007031:Hypothalamus / Q000502:physiology; D047908:Intracellular Signaling Peptides and Proteins / Q000502:physiology; D009446:Neurobiology; D009479:Neuropeptides / Q000502:physiology; D009638:Norepinephrine / Q000502:physiology; D000068797:Orexins; D012119:Respiration; D012701:Serotonin / Q000502:physiology; D012890:Sleep / Q000502:physiology*; D012894:Sleep Stages / Q000502:physiology; D014851:Wakefulness / Q000502:physiology*
chemical_list: D047908:Intracellular Signaling Peptides and Proteins; D009479:Neuropeptides; D000068797:Orexins; D012701:Serotonin; D000109:Acetylcholine; D009638:Norepinephrine