title: First characterization of fluoroquinolone resistance in Streptococcus suis.
abstract: We have identified and sequenced the genes encoding the quinolone-resistance determining region (QRDR) of ParC and GyrA in fluoroquinolone-susceptible and -resistant Streptococcus suis clinical isolates. Resistance is the consequence of single point mutations in the QRDRs of ParC and GyrA and is not due to clonal spread of resistant strains or horizontal gene transfer with other bacteria.
authors.affiliation: Departamento de Sanidad Animal, Facultad de Veterinaria, Universidad Complutense de Madrid, 28040 Madrid, Spain.
authors.forename: Jose Antonio
authors.initials: JA
authors.lastname: Escudero
authors.forename: Alvaro
authors.initials: A
authors.lastname: San Millan
authors.forename: Ana
authors.initials: A
authors.lastname: Catalan
authors.forename: Adela G
authors.initials: AG
authors.lastname: de la Campa
authors.forename: Estefania
authors.initials: E
authors.lastname: Rivero
authors.forename: Gema
authors.initials: G
authors.lastname: Lopez
authors.forename: Lucas
authors.initials: L
authors.lastname: Dominguez
authors.forename: Miguel Angel
authors.initials: MA
authors.lastname: Moreno
authors.forename: Bruno
authors.initials: B
authors.lastname: Gonzalez-Zorn
mesh_terms: D000595:Amino Acid Sequence; D027081:DNA Gyrase / Q000235:genetics; D027101:DNA Topoisomerase IV / Q000235:genetics; D024881:Drug Resistance, Bacterial / Q000235:genetics; D005260:Female; D024841:Fluoroquinolones / Q000494:pharmacology*; D005798:Genes, Bacterial; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D017354:Point Mutation; D012336:RNA, Ribosomal, 16S / Q000235:genetics; D016415:Sequence Alignment; D017011:Streptococcus suis / Q000187:drug effects / Q000235:genetics
chemical_list: D024841:Fluoroquinolones; D012336:RNA, Ribosomal, 16S; D027101:DNA Topoisomerase IV; D027081:DNA Gyrase