title: Sentra: a database of signal transduction proteins for comparative genome analysis.
abstract: Sentra (http://compbio.mcs.anl.gov/sentra), a database of signal transduction proteins encoded in completely sequenced prokaryotic genomes, has been updated to reflect recent advances in understanding signal transduction events on a whole-genome scale. Sentra consists of two principal components, a manually curated list of signal transduction proteins in 202 completely sequenced prokaryotic genomes and an automatically generated listing of predicted signaling proteins in 235 sequenced genomes that are awaiting manual curation. In addition to two-component histidine kinases and response regulators, the database now lists manually curated Ser/Thr/Tyr protein kinases and protein phosphatases, as well as adenylate and diguanylate cyclases and c-di-GMP phosphodiesterases, as defined in several recent reviews. All entries in Sentra are extensively annotated with relevant information from public databases (e.g. UniProt, KEGG, PDB and NCBI). Sentra's infrastructure was redesigned to support interactive cross-genome comparisons of signal transduction capabilities of prokaryotic organisms from a taxonomic and phenotypic perspective and in the framework of signal transduction pathways from KEGG. Sentra leverages the PUMA2 system to support interactive analysis and annotation of signal transduction proteins by the users.
authors.affiliation: Computational Biology Group, Mathematics and Computer Science Division, Argonne National Laboratory, Argonne, IL 60439, USA.
authors.forename: Mark
authors.initials: M
authors.lastname: D'Souza
authors.forename: Elizabeth M
authors.initials: EM
authors.lastname: Glass
authors.forename: Mustafa H
authors.initials: MH
authors.lastname: Syed
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhang
authors.forename: Alexis
authors.initials: A
authors.lastname: Rodriguez
authors.forename: Natalia
authors.initials: N
authors.lastname: Maltsev
authors.forename: Michael Y
authors.initials: MY
authors.lastname: Galperin
mesh_terms: D019843:Archaeal Proteins / Q000235:genetics* / Q000378:metabolism; D001426:Bacterial Proteins / Q000235:genetics* / Q000378:metabolism; D030562:Databases, Protein; D019143:Evolution, Molecular; D023281:Genomics; D020407:Internet; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics* / Q000378:metabolism; D015398:Signal Transduction / Q000235:genetics*; D014584:User-Computer Interface
chemical_list: D019843:Archaeal Proteins; D001426:Bacterial Proteins; D047908:Intracellular Signaling Peptides and Proteins