C35 terpenoids from the bark of Calocedrus macrolepis var. formosana with activity against human cancer cell lines.
Ferrugicadinol (1) and ferrugieudesmol (2), two new compounds with a unique C35 terpene skeleton, were isolated from the bark of Calocedrus macrolepis var. formosana. Their structures were elucidated principally from spectroscopic evidence. The two new C35 terpenes showed cytotoxicity against human oral epidermoid carcinoma KB cells with IC50 values ranging from 11 to 14 microM.
Hsieh
Chin-Lin
CL
Department of Chemistry, National Taiwan University, Taipei, Taiwan 106.
Tseng
Mei-Huims
MH
Shao
Yi-Yuan
YY
Chang
Jang-Yang
JY
Kuo
Ching-Chuan
CC
Chang
Chi-Yen
CY
Kuo
Yueh-Hsiung
YH
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor; D029779:Cupressaceae / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020128:Inhibitory Concentration 50; D007624:KB Cells; D024301:Plant Bark / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D013624:Taiwan; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
D000972:Antineoplastic Agents, Phytogenic; D013729:Terpenes; C516751:ferrugicadinol; C516752:ferrugieudesmol