A critical survey of fish measurements in populations of the southern Urals.
A critical survey of all published measurements made so far aimed at retrospective biological dosimetry using fluorescence in situ hybridisation (FISH) techniques on some workers at the Mayak reprocessing plant and on members of the Techa River cohort is given. Each individual has a recorded dose derived from personal monitoring measurements, usually external gamma-rays for Mayak workers or from reconstruction techniques, usually internally derived for the Techa River cohort. From the person's age, which affects the control level, and the stated dose, an expected number of translocations is calculated for each individual and comparisons made to the observed numbers of translocations. From this, an assessment of how well FISH studies can help to validate existing estimates of dose is made. This varies from study to study. Good agreement is generally obtained for the Techa River cohort and lower doses of the Mayak cohort. Rather poorer agreement applies to the more highly exposed Mayak workers. Some of the discrepancy could be because the FISH painting technique was new and was applied to populations before a proper investigation on how to use it for retrospective biological dosimetry had taken place. In addition, too few cells were generally scored per individual so that statistical uncertainties were large.
Edwards
A A
AA
Health Protection Agency, Radiation Protection Division, Didcot, Oxfordshire, UK. alan.edwards@hpa-rp.org.uk
Szłuińska
M
M
D000368:Aged; D020223:Chromosome Painting / Q000592:standards*; D003625:Data Collection; D004307:Dose-Response Relationship, Radiation; D004781:Environmental Exposure; D005260:Female; D005720:Gamma Rays; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D008875:Middle Aged; D011153:Population; D012426:Russia; D014178:Translocation, Genetic; D014875:Water Pollutants, Radioactive / Q000633:toxicity*
D014875:Water Pollutants, Radioactive