Computer modelling of the sinoatrial node.
Over the past decades patch-clamp experiments have provided us with detailed information on the different types of ion channels that are present in the cardiac cell membrane. Sophisticated cardiac cell models based on these data can help us understand how the different types of ion channels act together to produce the cardiac action potential. In the field of biological pacemaker engineering, such models provide important instruments for the assessment of the functional implications of changes in density of specific ion channels aimed at producing stable pacemaker activity. In this review, an overview is given of the progress made in cardiac cell modelling, with particular emphasis on the development of sinoatrial (SA) nodal cell models. Also, attention is given to the increasing number of publicly available tools for non-experts in computer modelling to run cardiac cell models.
Wilders
Ronald
R
Department of Physiology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands. r.wilders@amc.uva.nl
D000200:Action Potentials / Q000502:physiology; D000818:Animals; D003198:Computer Simulation / Q000639:trends*; D006801:Humans; D020407:Internet; D007473:Ion Channels / Q000502:physiology; D008955:Models, Cardiovascular; D032383:Myocytes, Cardiac / Q000502:physiology; D012849:Sinoatrial Node / Q000502:physiology*; D012984:Software
D007473:Ion Channels