Percutaneous coronary intervention increases leptin and decreases adiponectin levels.
OBJECTIVE
The study was designed to examine the effect of percutaneous coronary intervention (PCI) on adiponectin and leptin levels. We have previously demonstrated that PCI triggers a systemic inflammatory response. We hypothesized that inflammation participates in the pathogenesis of diabetes mellitus and the metabolic syndrome by modulating levels of adiponectin and leptin.


METHODS
Prospective study in which inflammation was induced by PCI.


METHODS
Forty-eight patients with stable coronary artery disease and without diabetes mellitus.


METHODS
High-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), leptin and adiponectin were measured at baseline and 48 h after the procedure.


RESULTS
Following PCI, hs-CRP increased by 211%, IL-6 by 87% and leptin by 19%, while adiponectin decreased by 14% (P < 0.001 for all). The change in IL-6 correlated with that in hs-CRP (rho = 0.32; P = 0.027), as did the changes in IL-6 and leptin (rho = 0.31; P = 0.03). The change in adiponectin, however, did not correlate with the change in any of the other markers.


CONCLUSIONS
This study demonstrates that PCI affects the levels of adiponectin and leptin within 48 h. These effects may be secondary to the inflammatory response triggered by PCI.
Azar
Rabih R
RR
Division of Cardiology, Hotel Dieu de France Hospital and the Saint-Joseph University School of medicine, Beirut, Lebanon. razar@usj.edu.lb
Sarkis
Antoine
A
Salameh
Elie
E
Gannagé-Yared
Marie-Hélène
MH
Amm-Azar
Mireille
M
Badaoui
Georges
G
Germanos
Mirna
M
Kassab
Roland
R
D052242:Adiponectin / Q000097:blood*; D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D003327:Coronary Disease / Q000097:blood* / Q000276:immunology / Q000628:therapy*; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D020738:Leptin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D011446:Prospective Studies; D018709:Statistics, Nonparametric
D052242:Adiponectin; D015415:Biomarkers; D015850:Interleukin-6; D020738:Leptin; D002097:C-Reactive Protein