[The effect of the time of death on the reactivity of rat caudal artery regulated by NA with a simultaneous use of NOS, CG and COX inhibitors. Part I].
The investigations were carried out on NA-perfused rat caudal arteries in four different time groups. Inhibitors of NO synthase, CG and COX were used simultaneously to explain the effect of the time of death on biochemical mechanisms regulating the function of metabotropic receptors. The study demonstrated that using the NO synthase inhibitor improved post mortem arterial reactivity, what indicated maintained endogenous NO synthesis after death. The CG inhibitor was also found to improve arterial reactivity and intracellular Ca++ ion concentration. No improvement in arterial reactivity was observed when COX was used in the experiment.
Bloch-Bogusławska
Elzbieta
E
Katedry i Zakładu Medycyny Sadowej UMK w Toruniu CM w Bydgoszczy.
D000818:Animals; D017209:Apoptosis / Q000187:drug effects / Q000502:physiology*; D001158:Arteries / Q000187:drug effects / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology*; D006162:Guanylate Cyclase / Q000037:antagonists & inhibitors; D007425:Intracellular Membranes / Q000378:metabolism; D008297:Male; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors*; D011180:Postmortem Changes; D051381:Rats; D017208:Rats, Wistar; D012445:Sacrococcygeal Region; D013623:Tail / Q000098:blood supply; D013997:Time Factors
D016861:Cyclooxygenase Inhibitors; D019001:Nitric Oxide Synthase; D006162:Guanylate Cyclase; D002118:Calcium