title: Myoinositol/folic acid combination for the treatment of erectile dysfunction in type 2 diabetes men: a double-blind, randomized, placebo-controlled study.
abstract: Erectile dysfunction is a common complication of diabetes. Diabetes can cause neuropathy or damage to nerves throughout your body, including the penis. Damaged nerves can't communicate properly. So even though you might be emotionally stimulated to have intercourse, nerve damage means that information isn't relayed to the penis, and it doesn't respond. In addition, poor blood sugar control can inhibit nitric oxide production. Lack of nitric oxide can prevent the pressure of blood in the corpora cavernosa from rising enough to close off penile veins, allowing blood to flow out of the penis instead of remaining trapped for an erection. This prospective, randomized, double-blind, placebo-controlled study included 176 patients with type 2 diabetes. The daily 4 g dose of inositol plus 400 microg of folic acid or placebo was divided and given in three doses. The present study demonstrates that Myoinositol/folic acid combination, deserves consideration as therapeutic agent for preventing and treating erectile dysfunction in diabetic men, probably by virtue of both their chronic metabolic, acute ROS scavenging, and NO protective beneficial effects.
authors.affiliation: First Institute of Obstetrics and Gynecology, University La Sapienza, Rome, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Agostini
authors.forename: F
authors.initials: F
authors.lastname: Rossi
authors.forename: R
authors.initials: R
authors.lastname: Pajalich
mesh_terms: D000328:Adult; D004311:Double-Blind Method; D004338:Drug Combinations; D007172:Erectile Dysfunction / Q000188:drug therapy* / Q000209:etiology*; D005492:Folic Acid / Q000627:therapeutic use*; D006801:Humans; D007294:Inositol / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D014815:Vitamins / Q000627:therapeutic use*
chemical_list: D004338:Drug Combinations; D014815:Vitamins; D007294:Inositol; D005492:Folic Acid