Helicobacter pylori adhesion to carbohydrates.
Adherence of bacterial pathogens to host tissues contributes to colonization and virulence and typically involves specific interactions between bacterial proteins called adhesins and cognate oligosaccharide (glycan) or protein motifs in the host that are used as receptors. A given pathogen may have multiple adhesins, each specific for a different set of receptors and, potentially, with different roles in infection and disease. This chapter provides strategies for identifying and analyzing host glycan receptors and the bacterial adhesins that exploit them as receptors, with particular reference to adherence of the gastric pathogen Helicobacter pylori.
Aspholm
Marina
M
Department of Molecular Biosciences, University of Oslo, Oslo, Norway.
Kalia
Awdhesh
A
Ruhl
Stefan
S
Schedin
Staffan
S
Arnqvist
Anna
A
Lindén
Sara
S
Sjöström
Rolf
R
Gerhard
Markus
M
Semino-Mora
Cristina
C
Dubois
Andre
A
Unemo
Magnus
M
Danielsson
Dan
D
Teneberg
Susann
S
Lee
Woo-Kon
WK
Berg
Douglas E
DE
Borén
Thomas
T
D001422:Bacterial Adhesion / Q000502:physiology*; D050260:Carbohydrate Metabolism; D016480:Helicobacter pylori / Q000502:physiology*; D006801:Humans