Serum anti-Fcgamma receptor autoantibodies in patients with alopecia areata.
Although anti-Fcgamma receptor antibodies (Abs) are detected in various autoimmune diseases, there have been no studies about the anti-Fcgamma receptor Abs in alopecia areata (AA). To detect the anti-Fcgamma receptor Abs in patients with AA and their clinical correlations, Serum samples from 72 patients with AA and 23 normal controls were examined by enzyme-linked immunosorbent assay assessing anti-Fcgamma receptor Ab levels. Anti-Fcgamma receptor I Abs were significantly frequently detected in patients with AA compared with normal controls. Furthermore, the detection of anti-Fcgamma receptor I Abs significantly inversely correlated with the disease duration. These results suggest that anti-Fcgamma receptor I Ab and Fcgamma receptor I play an important role in the regulation of AA, are useful for a marker of the disease prognosis and are worth intense research for the reasonable and specific therapy of AA.
Kuwano
Yoshihiro
Y
Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan.
Fujimoto
Manabu
M
Watanabe
Rei
R
Asashima
Nobuko
N
Nakashima
Hiroko
H
Ohno
Hiroki
H
Yano
Shoichiro
S
Yazawa
Norihito
N
Okochi
Hitoshi
H
Tamaki
Kunihiko
K
D000293:Adolescent; D000328:Adult; D000368:Aged; D000506:Alopecia Areata / Q000097:blood* / Q000473:pathology; D015703:Antigens, CD / Q000276:immunology; D001323:Autoantibodies / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D018450:Disease Progression; D005260:Female; D058851:GPI-Linked Proteins; D006801:Humans; D008297:Male; D008875:Middle Aged; D017452:Receptors, IgG / Q000276:immunology*
D015703:Antigens, CD; D001323:Autoantibodies; D015415:Biomarkers; C489017:FCGR1A protein, human; C428200:FCGR3B protein, human; C080568:Fc gamma receptor IIA; C080572:Fc gamma receptor IIC; D058851:GPI-Linked Proteins; D017452:Receptors, IgG