Synthesis of pyochelin-norfloxacin conjugates.
Using synthetic functionalized analogues of pyochelin, a siderophore common to several pathogenic Pseudomonas and Burkholderia species, four fluoroquinolone-pyochelin conjugates were efficiently synthesized and evaluated for their biological activities.
Rivault
Freddy
F
Métaux et Microorganismes: Chimie, Biologie et Applications, UMR 7175-LC1 Institut Gilbert Laustriat CNRS-Université Louis Pasteur (Strasbourg I), ESBS, Boulevard Sébastien Brant, F-67400 Illkirch, France.
Liébert
Clémence
C
Burger
Alain
A
Hoegy
Françoise
F
Abdallah
Mohamed A
MA
Schalk
Isabelle J
IJ
Mislin
Gaëtan L A
GL
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D016956:Burkholderia cepacia / Q000187:drug effects; D007502:Iron Chelating Agents / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D009643:Norfloxacin / Q000737:chemistry* / Q000494:pharmacology*; D010636:Phenols / Q000737:chemistry* / Q000494:pharmacology*; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013329:Structure-Activity Relationship; D013844:Thiazoles / Q000737:chemistry* / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D007502:Iron Chelating Agents; D010636:Phenols; D013844:Thiazoles; C025316:pyochelin; D009643:Norfloxacin