title: Pravastatin improved glucose metabolism associated with increasing plasma adiponectin in patients with impaired glucose tolerance and coronary artery disease.
abstract: Reduced incidence of type-2 diabetes has been shown in patients treated with pravastatin. Adiponectin can exhibit beneficial effects on glucose metabolism. We investigated whether pravastatin could improve glucose tolerance associated with increasing adiponectin levels in patients with impaired glucose tolerance (IGT). This study consisted of 40 coronary artery disease (CAD) patients with IGT assessed by oral glucose tolerance test (OGTT). Patients were randomized to receive pravastatin (n=20) or no lipid-lowering medications (control group, n=20) for 6 months, after which OGTT was repeated and adiponectin levels were measured. Pravastatin treatment significantly decreased levels of total cholesterol (16%), low-density lipoprotein cholesterol (23%) and high-sensitivity C-reactive protein (37%) (p<0.01, respectively). At 2h in OGTT, pravastatin significantly improved hyperglycemia (-14%) and hyperinsulinemia (-23%). Pravastatin treatment significantly elevated plasma adiponectin levels (35%; p<0.001) but not in the control group. The glucose reduction at 2h post-OGTT was significantly associated with increased levels of adiponectin (r=-0.462; p=0.003). Pravastatin treatment is an independent predictor for improvement of post-loaded hyperglycemia (odds ratio; 5.7; 95% confidence interval 1.7-19.3; p=0.003) and achieved beneficial conversion from IGT to normal glucose tolerance (40%; p=0.03). Pravastatin exhibits beneficial effects on glucose metabolism especially in the postprandial state associated with increasing plasma adiponectin levels in CAD patients with IGT.
authors.affiliation: Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto City, Kumamoto 860-8556, Japan. ssugiyam@kumamoto-u.ac.jp
authors.forename: Seigo
authors.initials: S
authors.lastname: Sugiyama
authors.forename: Hironobu
authors.initials: H
authors.lastname: Fukushima
authors.forename: Kiyotaka
authors.initials: K
authors.lastname: Kugiyama
authors.forename: Hidetomo
authors.initials: H
authors.lastname: Maruyoshi
authors.forename: Sunao
authors.initials: S
authors.lastname: Kojima
authors.forename: Tohru
authors.initials: T
authors.lastname: Funahashi
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Sakamoto
authors.forename: Yoko
authors.initials: Y
authors.lastname: Horibata
authors.forename: Keisuke
authors.initials: K
authors.lastname: Watanabe
authors.forename: Hidenobu
authors.initials: H
authors.lastname: Koga
authors.forename: Koichi
authors.initials: K
authors.lastname: Sugamura
authors.forename: Fumiyuki
authors.initials: F
authors.lastname: Otsuka
authors.forename: Iichirou
authors.initials: I
authors.lastname: Shimomura
authors.forename: Hisao
authors.initials: H
authors.lastname: Ogawa
mesh_terms: D052242:Adiponectin / Q000097:blood; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism*; D003324:Coronary Artery Disease / Q000188:drug therapy*; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000494:pharmacology*; D006943:Hyperglycemia / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D019518:Postprandial Period; D017035:Pravastatin / Q000494:pharmacology*
chemical_list: D052242:Adiponectin; D001786:Blood Glucose; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D017035:Pravastatin