Oxidative cross-coupling through double transmetallation: surprisingly high selectivity for palladium-catalyzed cross-coupling of alkylzinc and alkynylstannanes.
Two different organometallic reagents now can cross-couple together with the oxidative cross-coupling strategy. Palladium catalyzed oxidative cross-couplings of alkylzinc and alkynylstannane reagents using desyl chloride as the oxidant have been explored, which produce the desired Csp-Csp3 cross-coupling product in surprisingly high selectivity and yields. The current catalytic system tolerates the presence of beta-H, and the reactions using long chain alkyl zinc reagents gave the cross-coupling product in excellent yields and selectivities.
Zhao
Yingsheng
Y
College of Chemistry and Molecular Science, Wuhan University, Wuhan, 430072, P. R. China.
Wang
Haibo
H
Hou
Xiaohui
X
Hu
Yanhe
Y
Lei
Aiwen
A
Zhang
Heng
H
Zhu
Lizheng
L