TEDDY--The Environmental Determinants of Diabetes in the Young: an observational clinical trial.
The aim of the TEDDY study is to identify infectious agents, dietary factors, or other environmental agents, including psychosocial factors, which may either trigger islet autoimmunity, type 1 diabetes mellitus (T1DM), or both. The study has two end points: (a) appearance of islet autoantibodies and (b) clinical diagnosis of T1DM. Six clinical centers screen newborns for high-risk HLA genotypes. As of December 2005 a total of 54,470 newborns have been screened. High-risk HLA genotypes among 53,560 general population (GP) infants were 2576 (4.8%) and among 910 newborns with a first-degree relative (FDR) were 194 (21%). A total of 1061 children have been enrolled. The initial enrollment results demonstrate the feasibility of this complex and demanding a prospective study.
Hagopian
William A
WA
Pacific Northwest Research Institute, Seattle, WA 98122, USA.
Lernmark
Ake
A
Rewers
Marian J
MJ
Simell
Olli G
OG
She
Jin-Xiong
JX
Ziegler
Anette G
AG
Krischer
Jeffrey P
JP
Akolkar
Beena
B
D000293:Adolescent; D000483:Alleles; D001323:Autoantibodies / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D003922:Diabetes Mellitus, Type 1 / Q000175:diagnosis / Q000235:genetics*; D004781:Environmental Exposure; D005240:Feasibility Studies; D005500:Follow-Up Studies; D005820:Genetic Testing; D006680:HLA Antigens / Q000235:genetics; D006239:Haplotypes; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007515:Islets of Langerhans / Q000276:immunology; D012307:Risk Factors; D013997:Time Factors
D001323:Autoantibodies; D006680:HLA Antigens