title: Porcine acute phase protein concentrations in different diseases in field conditions.
abstract: Five acute phase proteins (APPs) [C-reactive protein (CRP), serum amyloid A (SAA), haptoglobin (Hp), pig-MAP and albumin] were measured in pigs with naturally occurring infections by porcine reproductive and respiratory syndrome virus (PRRSV), Aujeszky's disease virus (ADV), porcine circovirus type 2 (PCV2) and Mycoplasma hyopneumoniae, and in animals with tail and ear bites, arthritis and other acute inflammatory processes. Healthy specific pathogen-free (SPF) pigs were used as controls. In PRRSV-infected pigs, all APPs with the exception of pig-MAP exhibited significant changes compared with controls. In animals affected with ADV only Hp presented changes of statistical significance, whereas pigs with PCV2 showed marked modifications in all APPs tested. Animals affected with Mycoplasmosis showed concentrations of all positive APPs significantly above levels obtained in SPF pigs, though albumin concentrations did not differ from controls. Finally, all APPs studied showed substantial changes in pigs with acute inflammation. The results indicated that an acute phase response was developed in the different diseases studied, this response being higher in animals with clinical signs and concurrent bacterial processes. Haptoglobin would be the APP that better reflects pathological states; however, to get more complete and valuable information it might be advisable to perform APPs profiles including another APP, such as CRP or SAA.
authors.affiliation: Animal Medicine and Surgery Department, Faculty of Veterinary Medicine, University of Murcia, 30100 Murcia, Spain.
authors.forename: M D
authors.initials: MD
authors.lastname: Parra
authors.forename: P
authors.initials: P
authors.lastname: Fuentes
authors.forename: F
authors.initials: F
authors.lastname: Tecles
authors.forename: S
authors.initials: S
authors.lastname: Martínez-Subiela
authors.forename: J S
authors.initials: JS
authors.lastname: Martínez
authors.forename: A
authors.initials: A
authors.lastname: Muñoz
authors.forename: J J
authors.initials: JJ
authors.lastname: Cerón
mesh_terms: D000209:Acute-Phase Proteins / Q000276:immunology*; D000818:Animals; D000831:Animals, Newborn; D002097:C-Reactive Protein / Q000276:immunology; D016022:Case-Control Studies; D018173:Circoviridae Infections / Q000097:blood / Q000276:immunology / Q000662:veterinary; D017925:Circovirus / Q000276:immunology; D006242:Haptoglobins / Q000276:immunology; D045705:Mycoplasma hyopneumoniae / Q000276:immunology; D045729:Pneumonia of Swine, Mycoplasmal / Q000097:blood / Q000276:immunology; D019318:Porcine Reproductive and Respiratory Syndrome / Q000097:blood / Q000276:immunology; D011557:Pseudorabies / Q000097:blood / Q000276:immunology; D000685:Serum Amyloid A Protein / Q000276:immunology; D013047:Specific Pathogen-Free Organisms; D013552:Swine; D013553:Swine Diseases / Q000097:blood* / Q000276:immunology* / Q000382:microbiology / Q000821:virology
chemical_list: D000209:Acute-Phase Proteins; D006242:Haptoglobins; D000685:Serum Amyloid A Protein; D002097:C-Reactive Protein