title: Could streptococcal erythrogenic toxin B induce inflammation prior to the development of immune complex deposits in poststreptococcal glomerulonephritis?
abstract: Acute poststreptococcal glomerulonephritis (APSGN) is a consequence of the immune response to streptococcal antigens with further in situ antigen-antibody interaction and deposition of circulating immune complexes, resulting in the activation of complement and the inflammatory process. These events are related to a previous antibody response. However, early renal events, when circulating streptococcal antigens bind to the kidney during streptococcal infection, remain unknown. Cationic streptococcal erythrogenic toxin type B (ETB) and its precursor (ETBP) are largely produced by nephritogenic streptococci and have high affinity for anionic glomerular structures. Renal deposition of ETB/ETBP makes conceivable a possible interaction between these streptococcal proteins with intrinsic glomerular cells or infiltrating leukocytes. Since ETB/ETBP are chemotactic for leukocytes and capable of inducing proliferation, cytokine and chemokine production, expression of adhesion molecules and apoptosis in renal cells and leukocytes, the early presence of these proteins could be a relevant event before and during antigen-antibody interaction takes place in renal tissues.
authors.affiliation: Instituto de Investigaciones Clinicas Dr. Americo Negrette, Facultad de Medicina, Maracaibo, Venezuela. mosquera99ve@yahoo.com
authors.forename: Jesus
authors.initials: J
authors.lastname: Mosquera
authors.forename: Maritza
authors.initials: M
authors.lastname: Romero
authors.forename: Ninoska
authors.initials: N
authors.lastname: Viera
authors.forename: Jaimar
authors.initials: J
authors.lastname: Rincon
authors.forename: Adriana
authors.initials: A
authors.lastname: Pedreáñez
mesh_terms: D000208:Acute Disease; D017209:Apoptosis; D001426:Bacterial Proteins / Q000276:immunology* / Q000378:metabolism*; D002448:Cell Adhesion; D049109:Cell Proliferation; D002633:Chemotaxis; D016207:Cytokines / Q000378:metabolism; D005098:Exotoxins / Q000276:immunology* / Q000378:metabolism*; D005921:Glomerulonephritis / Q000276:immunology / Q000382:microbiology*; D006801:Humans; D007249:Inflammation / Q000503:physiopathology*; D007668:Kidney / Q000737:chemistry / Q000473:pathology; D013290:Streptococcal Infections / Q000150:complications* / Q000276:immunology
chemical_list: D001426:Bacterial Proteins; D016207:Cytokines; D005098:Exotoxins; C027951:erythrogenic toxin