title: Occupational immunoglobulin E-mediated asthma due to Penicillium camemberti in a dry-sausage packer.
abstract: A 62-year-old female sausage packer reported progressive work-related asthma, rhinitis and contact urticaria after contact to dry sausages refined by moulds. Whereas skin prick tests with commercial mould extracts were negative, the patient showed weak skin sensitization to a cultivated mould sample from a dry sausage. Specific immunoglobulin E antibodies to various moulds were demonstrated by ImmunoCAP and antibodies to the cultivated mould sample were demonstrated by enzyme allergosorbent test. The mould was identified by pheno- and genotyping as Penicillium camemberti. Five atopic controls did not show sensitization with the same tests. Crossreactivity of P. camemberti and Penicillium notatum was shown by enzyme allergosorbent inhibition tests. Although no challenge tests were considered due to the patient's airway obstruction, a diagnosis of allergic occupational asthma was made. We conclude that immunoglobulin E-mediated allergic occupational asthma due to moulds may occur in dry sausage packers.
authors.affiliation: Research Institute for Occupational Medicine, Institutions for Statutory Accident Insurance and Prevention, Ruhr University, Bochum, Germany. merget@bgfa.de
authors.forename: R
authors.initials: R
authors.lastname: Merget
authors.forename: I
authors.initials: I
authors.lastname: Sander
authors.forename: P
authors.initials: P
authors.lastname: Rozynek
authors.forename: E
authors.initials: E
authors.lastname: Heinze
authors.forename: M
authors.initials: M
authors.lastname: Imoehl
authors.forename: M
authors.initials: M
authors.lastname: Raulf-Heimsoth
authors.forename: T
authors.initials: T
authors.lastname: Bruening
mesh_terms: D000485:Allergens; D001249:Asthma / Q000175:diagnosis / Q000276:immunology* / Q000503:physiopathology; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood*; D008461:Meat Products; D008462:Meat-Packing Industry; D008875:Middle Aged; D009784:Occupational Diseases / Q000175:diagnosis / Q000209:etiology* / Q000276:immunology; D010407:Penicillium; D012882:Skin Tests
chemical_list: D000485:Allergens; D007073:Immunoglobulin E