title: A SPINK1 gene mutation in a Thai patient with fibrocalculous pancreatic diabetes.
abstract: Fibrocalculous pancreatitis diabetes (FCPD), a late stage of tropical chronic pancreatitis (TCP), is classified as a secondary cause of diabetes mellitus resulting from pancreatic exocrine dysfunction. The distinctive features of FCPD and TCP are young age at onset, presence of large intraductal pancreatic calculi, and reported mainly in tropical developing countries. Their etiology is still obscure, but the autodigestion due to aberrant intraductal activation of zymogens by trypsin is thought to be a primary common event. Recently, mutations in SPINKI gene encoding a pancreatic secretory trypsin inhibitor have been reported in association with an increased risk of pancreatitis. We describe a heterozygous mutation, IVS3+2 T>C, of SPINK1 gene in a young Thai female patient with typical presentation of FCPD. To our knowledge, this is the first report of the SPINK1 gene mutation in a FCPD patient in Southeast Asia.
authors.affiliation: Department of Internal Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. Thiti.S@chula.ac.th
authors.forename: Thiti
authors.initials: T
authors.lastname: Snabboon
authors.forename: Wanee
authors.initials: W
authors.lastname: Plengpanich
authors.forename: Vitaya
authors.initials: V
authors.lastname: Sridama
authors.forename: Sarat
authors.initials: S
authors.lastname: Sunthornyothin
authors.forename: Sompongse
authors.initials: S
authors.lastname: Suwanwalaikorn
authors.forename: Weerapan
authors.initials: W
authors.lastname: Khovidhunkit
mesh_terms: D000293:Adolescent; D002352:Carrier Proteins / Q000235:genetics*; D005260:Female; D006801:Humans; D007328:Insulin / Q000627:therapeutic use; D009154:Mutation; D050500:Pancreatitis, Chronic / Q000188:drug therapy / Q000235:genetics* / Q000503:physiopathology; D014359:Trypsin Inhibitor, Kazal Pancreatic
chemical_list: D002352:Carrier Proteins; D007328:Insulin; C486642:SPINK1 protein, human; D014359:Trypsin Inhibitor, Kazal Pancreatic