title: [The clinical and functional features of chronic obstructive lung disease in patients with organic chlorine pesticides in blood].
abstract: Impact of pollutant human aggression is of great importance for the development of bronchopulmonary diseases. In the Republic of Uzbekistan, the environmental levels of pesticides are elevated as they are widely used in agriculture while growing cotton. Eighty-two patients with chronic obstructive lung disease (COLD) were studied in relation to the presence of blood chlorine- and phosphorus-containing pesticides. The latter were tested for their effect on the course of COLD. There was evidence that the higher blood levels of pesticides were, the more severe the clinical symptoms of the process and the more pronounced changes in the functional status of the bronchopulmonary apparatus were. The findings suggest that the blood content of organic chlorine pesticides affects the course of COLD. These compounds cause more significant clinical and functional impairments with the severe manifestations of mucous membrane morphofunctional rearrangement and with disruption of the body's adaptive potentials. These patients poorly respond to therapy, which required dose adjustment and longer drug use.
authors.forename: K M
authors.initials: KM
authors.lastname: Ubaĭdullaeva
mesh_terms: D000328:Adult; D000368:Aged; D000393:Air Pollutants / Q000009:adverse effects / Q000097:blood; D018450:Disease Progression; D017079:Exercise Tolerance / Q000502:physiology; D005260:Female; D005541:Forced Expiratory Volume / Q000502:physiology*; D006801:Humans; D006843:Hydrocarbons, Chlorinated / Q000009:adverse effects / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010575:Pesticides / Q000009:adverse effects / Q000097:blood*; D011379:Prognosis; D029424:Pulmonary Disease, Chronic Obstructive / Q000097:blood* / Q000503:physiopathology*; D014610:Uzbekistan
chemical_list: D000393:Air Pollutants; D006843:Hydrocarbons, Chlorinated; D010575:Pesticides