Uteroplacental circulation in early pregnancy complicated by threatened abortion supplemented with vaginal micronized progesterone or oral dydrogesterone.
OBJECTIVE
To compare the influence of vaginal micronized progesterone and oral dydrogesterone supplementation on uteroplacental circulation in early pregnancy that is complicated by threatened abortion.


METHODS
Randomized, parallel group, double-blind, double dummy-controlled study.


METHODS
Tertiary care university hospital.


METHODS
Fifty-three patients with threatened abortion and a living embryo.


METHODS
Three hundred milligrams of micronized vaginal progesterone or 30 mg of oral dydrogesterone daily supplementation for 6 weeks, serial transvaginal Doppler ultrasound measurement of pulsatility index, resistance index, and systolic/diastolic ratio of the spiral arteries, the uterine arteries, and the intrachorionic area.


METHODS
Uteroplacental blood flow.


RESULTS
The study demonstrated that vaginal progesterone administration, but not oral dydrogesterone treatment, results in the decrease in the spiral artery pulsatility and resistance index and systolic/diastolic ratio. Insignificant decrease in pulsatility index and resistance index of the uterine artery was observed at >9 weeks and was not associated with treatment regimen. Dydrogesterone treatment was only accompanied by the decrease in the uterine artery systolic/diastolic ratio.


CONCLUSIONS
Vaginal progesterone and oral dydrogesterone supplementation have a different influence on the uteroplacental circulation in early pregnancy that is complicated by threatened abortion.
Czajkowski
Krzysztof
K
Second Department of Obstetrics and Gynecology, Medical University of Warsaw, Warsaw, Poland.
Sienko
Jacek
J
Mogilinski
Mariusz
M
Bros
Magdalena
M
Szczecina
Roman
R
Czajkowska
Anna
A
D000033:Abortion, Threatened / Q000000981:diagnostic imaging / Q000188:drug therapy*; D000282:Administration, Intravaginal; D000284:Administration, Oral; D000328:Adult; D001158:Arteries; D001783:Blood Flow Velocity; D004311:Double-Blind Method; D004394:Dydrogesterone / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D021041:Placental Circulation / Q000187:drug effects*; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011374:Progesterone / Q000008:administration & dosage*; D018617:Ultrasonography, Doppler, Pulsed
D011374:Progesterone; D004394:Dydrogesterone