title: RamB, the transcriptional regulator of acetate metabolism in Corynebacterium glutamicum, is subject to regulation by RamA and RamB.
abstract: In Corynebacterium glutamicum, the transcriptional regulator RamB negatively controls the expression of genes involved in acetate metabolism. Here we show that RamB represses its own expression by direct interaction with a 13-bp motif in the ramB promoter region. Additionally, ramB expression is subject to carbon source-dependent positive control by RamA.
authors.affiliation: Department of Microbiology and Biotechnology, University of Ulm, 89069 Ulm, Germany.
authors.forename: Annette
authors.initials: A
authors.lastname: Cramer
authors.forename: Marc
authors.initials: M
authors.lastname: Auchter
authors.forename: Julia
authors.initials: J
authors.lastname: Frunzke
authors.forename: Michael
authors.initials: M
authors.lastname: Bott
authors.forename: Bernhard J
authors.initials: BJ
authors.lastname: Eikmanns
mesh_terms: D000085:Acetates / Q000378:metabolism* / Q000494:pharmacology; D001426:Bacterial Proteins / Q000235:genetics* / Q000378:metabolism; D015153:Blotting, Western; D048230:Corynebacterium glutamicum / Q000187:drug effects / Q000235:genetics* / Q000378:metabolism; D024202:Electrophoretic Mobility Shift Assay; D015964:Gene Expression Regulation, Bacterial; D005947:Glucose / Q000494:pharmacology; D008954:Models, Biological; D011401:Promoter Regions, Genetic; D011485:Protein Binding; D014158:Transcription, Genetic
chemical_list: D000085:Acetates; D001426:Bacterial Proteins; D005947:Glucose