Antibiotics--past, present, and future.
The drug therapy for diseases other than those caused by microbial agents involves treating the host. In infectious diseases therapy, the goal is to rid the host of the pathogen. Hence, drug therapy is aimed at the pathogen. Because a second living agent is involved in the triangle, drug therapy is affected by the pathogen's nature, its tissue specificity, and, most importantly, the changes it undergoes to survive. The history of antimicrobial therapy has clearly demonstrated that the drugs that are used to treat infections are also responsible for making them more difficult to treat in future. The only way to keep antimicrobial agents useful is to use them appropriately and judiciously.
Khardori
Nancy
N
Department of Internal Medicine, Southern Illinois University School of Medicine, PO Box 19636, Springfield, IL 62794-9636, USA. nkhardori@siumed.edu
D000617:Aminoglycosides / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000627:therapeutic use; D001435:Bacteriophages / Q000502:physiology; D002511:Cephalosporins / Q000627:therapeutic use; D017576:Daptomycin / Q000627:therapeutic use; D004352:Drug Resistance, Microbial / Q000235:genetics; D004358:Drug Therapy / Q000639:trends; D024841:Fluoroquinolones / Q000627:therapeutic use; D006020:Glycopeptides / Q000627:therapeutic use; D006801:Humans; D018942:Macrolides / Q000627:therapeutic use; D023303:Oxazolidinones / Q000627:therapeutic use; D025361:Streptogramins / Q000627:therapeutic use; D013754:Tetracyclines / Q000627:therapeutic use; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000627:therapeutic use; D047090:beta-Lactams
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D024841:Fluoroquinolones; D006020:Glycopeptides; D018942:Macrolides; D023303:Oxazolidinones; D025361:Streptogramins; D013754:Tetracyclines; D047090:beta-Lactams; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D017576:Daptomycin