title: Efficacy of concentrated autologous platelet-derived growth factors in chronic lower-extremity wounds.
abstract: The efficacy of concentrated autologous platelet-derived growth factors in the healing and closure of chronic lower-extremity wounds was evaluated in 24 patients with 33 lower-extremity wounds treated previously for at least 6 months using traditional methods. Surgical wound debridement was performed to convert chronic ulcers into acute wounds. Concentrated autologous platelet-derived growth factors and thrombin were applied to the wound bases and protected with a nonadhering compression dressing that remained intact for 7 days. Wounds were evaluated and the concentrate was reapplied every 2 weeks. Wound closure and complete epithelialization was achieved in 20 wounds. Seventy-five percent or greater wound closure was obtained in three wounds, 50% to 74% closure in three wounds, and 25% to 49% closure in two wounds. Five wounds displayed no improvement. Mean time to complete closure was 11.15 weeks. The application of concentrated autologous platelet-derived growth factors and thrombin resulted in substantial wound healing and wound-diameter reduction. This technique constitutes a safe and effective treatment option and avoids lengthy treatment periods that increase the potential for infection.
authors.affiliation: Division of Podiatric Surgery, Department of Orthopaedics, Mount Sinai Hospital of Queens, Mount Sinai School of Medicine, Astoria, NY, USA.
authors.forename: Jody Peter
authors.initials: JP
authors.lastname: McAleer
authors.forename: Eric
authors.initials: E
authors.lastname: Kaplan
authors.forename: Gianni
authors.initials: G
authors.lastname: Persich
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003646:Debridement; D005260:Female; D006801:Humans; D007871:Leg Ulcer / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D010982:Platelet-Derived Growth Factor / Q000627:therapeutic use*; D012449:Safety; D016896:Treatment Outcome; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D010982:Platelet-Derived Growth Factor