title: Two new triterpenoid saponins isolated from Polygala japonica.
abstract: Bioassay guided investigation of whole parts of Polygala japonica afforded two new triterpenoid saponins, characterized as 3-O-beta-D-glucopyranosyl medicagenic acid 28-O-{beta-D-xylopyranosyl(1-->4)-[beta-D-apiofuranosyl(1-->3)]-alpha-L-rhamnopyranosyl(1-->2)-beta-D-glucopyranosyl} ester (1), 3-O-beta-D-glucopyranosyl 2-oxo-olean-12-en-23, 28-dioic acid 28-O-{beta-D-xylopyranosyl(1-->4)-[beta-D-apiofuranosyl(1-->3)]-alpha-L-rhamnopyranosyl(1-->2)-beta-D-glucopyranosyl} ester (2), together with four known triterpenoid saponins (3-6). Their structures were elucidated by spectroscopic and chemical methods. Saponins 3, 4 and 5 showed significant anti-inflammation effects on carrageenan-induced acute paw edema in mouse.
authors.affiliation: Department of Traditional Chinese Prescription, China Pharmaceutical University, Nanjing 210038, P.R. China.
authors.forename: Honglan
authors.initials: H
authors.lastname: Wang
authors.forename: Jie
authors.initials: J
authors.lastname: Gao
authors.forename: Danni
authors.initials: D
authors.lastname: Zhu
authors.forename: Boyang
authors.initials: B
authors.lastname: Yu
mesh_terms: D015394:Molecular Structure; D031801:Polygala / Q000737:chemistry*; D012503:Saponins / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry*
chemical_list: C516823:3-O-glucopyranosyl 2-oxoolean-12-en-23,28-dioic acid 28-O-(xylopyranosyl-1-4-(apiofuranosyl-1-3)rhamnopyranosyl-1-2-glucopyranosyl) ester; C516822:3-O-glucopyranosyl medicagenic acid 28-O-(xylopyranosyl-1-4-(apiofuranosyl-1-3)-rhamnopyranosyl-1-2-glucopyranosyl) ester; D012503:Saponins; D014315:Triterpenes