Automated synthesis of heterocycles on solid supports.
The creation of novel diverse heterocycle libraries is an indispensable requirement of modern drug discovery processes. Currently, library sizes of over 10,000 discrete compounds are viable using programmed synthesis on solid supports. This review discusses the recent advances in the automated solid-phase syntheses of heterocycles to generate libraries of bioactive products, and illustrates library sizes that have been obtained, robots used for production of libraries, points of diversity and number of steps on the resin.
Jung
Nicole
N
Institut für Organische Chemie, Universität Karlsruhe (TH), D-76131 Karlsruhe, Germany.
Encinas
Arantxa
A
Bräse
Stefan
S
D020650:Combinatorial Chemistry Techniques / Q000295:instrumentation / Q000379:methods*; D015195:Drug Design; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000145:classification; D015394:Molecular Structure; D012371:Robotics / Q000379:methods*; D013997:Time Factors
D006571:Heterocyclic Compounds