title: Tolerance to the glycopeptides vancomycin and teicoplanin in coagulase-negative staphylococci.
abstract: Tolerance to vancomycin and teicoplanin in 90 clinical isolates of coagulase-negative staphylococci (CoNS) was investigated by time-kill curve methodology. Only six strains, belonging to the Staphylococcus lugdunensis species, exhibited tolerance. The seven other S. lugdunensis strains tested displayed weak susceptibility to the bactericidal activity of glycopeptides compared to the other CoNS. These phenomena are of concern, since S. lugdunensis is recognized as one of the most pathogenic CoNS.
authors.affiliation: Groupe de Recherce sur les Antimicrobiens et les Microorganismes, U.P.R.E.S. EA 2656, I.F.R. 23, Université de Rouen, and Centre Hospitalier Universitaire, Rouen, France.
authors.forename: Ingrid
authors.initials: I
authors.lastname: Bourgeois
authors.forename: Martine
authors.initials: M
authors.lastname: Pestel-Caron
authors.forename: Jean-Francois
authors.initials: JF
authors.lastname: Lemeland
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Pons
authors.forename: Francois
authors.initials: F
authors.lastname: Caron
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D003030:Coagulase / Q000172:deficiency*; D004361:Drug Tolerance; D013203:Staphylococcal Infections / Q000188:drug therapy / Q000382:microbiology; D013210:Staphylococcus / Q000187:drug effects / Q000201:enzymology; D017334:Teicoplanin / Q000494:pharmacology*; D014640:Vancomycin / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D003030:Coagulase; D017334:Teicoplanin; D014640:Vancomycin