title: Comparison of manual tracing versus a semiautomatic radial measurement method in temporal lobe MRI volumetry for pharmacoresistant epilepsy.
abstract: BACKGROUND
  The aim of this study was to test a modified radial semiautomated volumetry technique (radial divider technique, RDT) versus the manual volumetry technique (MVT) for proportionality of temporal subvolumes in 30 patients with drug-resistant temporal lobe epilepsy.
  
  
  METHODS
  Included in the study were 30 patients (15 female, 15 male; mean age 39.6 years) with pharmacoresistant epilepsy (mean duration 26.6 years). MRI studies were performed preoperatively on a 1.5-T scanner. All image processing steps and volume measurements were performed using ANALYZE software. The volumes of six subregions were measured bilaterally; these included the superior temporal gyrus (STG), middle + inferior temporal gyrus (MITG), fusiform gyrus (FG), parahippocampal gyrus (PHG), amygdala (AM), and hippocampus (HP). Linear regression was used to investigate the relationship between the comparable subvolumes obtained with MVT and RDT.
  
  
  RESULTS
  Very high correlations (R (2) >0.95) between RDT and MVT were observed for the STG + MITG and the STG + MITG + FG, but low correlations for the PHG subvolumes and the combined PHG + HP + AM subvolumes. These observations were independent of the side of the pathology and of hemisphere.
  
  
  CONCLUSIONS
  The two measurement techniques provided highly reliable proportional results. This series in a homogeneous group of TLE patients suggests that the much quicker RDT is suitable for determining the volume of temporolateral and laterobasal temporal lobe compartments, of both the affected and the non-affected side and the right and left hemisphere.
authors.affiliation: Department of Neurosurgery, University of Bonn, Sigmund-Freud Str. 25, 53105, Bonn, Germany. Christian-Andreas.Mueller@ukb.uni-bonn.de
authors.forename: Christian-Andreas
authors.initials: CA
authors.lastname: Mueller
authors.forename: Jasmin
authors.initials: J
authors.lastname: Scorzin
authors.forename: Roy
authors.initials: R
authors.lastname: Koenig
authors.forename: Horst
authors.initials: H
authors.lastname: Urbach
authors.forename: Rolf
authors.initials: R
authors.lastname: Fimmers
authors.forename: Josef
authors.initials: J
authors.lastname: Zentner
authors.forename: Thomas-Nicolas
authors.initials: TN
authors.lastname: Lehmann
authors.forename: Johannes
authors.initials: J
authors.lastname: Schramm
mesh_terms: D000293:Adolescent; D000328:Adult; D004833:Epilepsy, Temporal Lobe / Q000473:pathology*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D016014:Linear Models; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results