Synthesis and cytotoxic activities of 4,5-diarylisoxazoles.
A series of 4,5-diarylisoxazoles related to combretastatin A-4 (CA-4) were synthesized and evaluated for cytotoxicity against three human cancer cell lines. Among them, compound 6e showed better cytotoxic activity than CA-4 in HeLa and HepG2 cell lines assayed with IC(50) value as low as 0.022 and 0.065nM, respectively.
Sun
Chang-Ming
CM
National Research Institute of Chinese Medicine, No. 155-1, Section 2, Li-Nung Street, Peitou, Taipei 112, Taiwan, ROC.
Lin
Lee-Gin
LG
Yu
Hsi-Jung
HJ
Cheng
Chih-Yu
CY
Tsai
Ya-Chuan
YC
Chu
Chi-Wei
CW
Din
Yi-Hui
YH
Chau
Yat-Pang
YP
Don
Ming-Jaw
MJ
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002453:Cell Cycle / Q000187:drug effects; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D006801:Humans; D007202:Indicators and Reagents; D007555:Isoxazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D007202:Indicators and Reagents; D007555:Isoxazoles