Axon guidance: ephrins at WRK on the midline.
Recent findings indicate that the embryonic motor neurons act as gatekeepers to regulate midline crossing during development of the nematode Caenorhabditis elegans. The newly identified protein WRK-1 and ephrins cooperate to prevent longitudinal axons from crossing the midline.
Quinn
Christopher C
CC
UMDNJ-Robert Wood Johnson Medical School, Department of Pathology, 675 Hoes Lane, Piscataway, New Jersey 08854-5635, USA. quinncc@umdnj.edu
Wadsworth
William G
WG
D000818:Animals; D001369:Axons / Q000378:metabolism / Q000502:physiology*; D017173:Caenorhabditis elegans / Q000196:embryology*; D029742:Caenorhabditis elegans Proteins / Q000378:metabolism*; D036342:Ephrins / Q000378:metabolism*; D009046:Motor Neurons / Q000378:metabolism / Q000502:physiology*; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D009420:Nervous System / Q000196:embryology*; D015398:Signal Transduction / Q000502:physiology*
D029742:Caenorhabditis elegans Proteins; D036342:Ephrins; D009419:Nerve Tissue Proteins; C515032:WRK-1 protein, C elegans