Fatal cephalosporin-induced acute hypersensitivity myocarditis.
A frequently fatal, although rare, side effect of cephalosporin antibiotics is noninfectious myocarditis. We report two cases of hypersensitivity myocarditis secondary to administration of cephalosporin antibiotics. In both cases, acute hypersensitivity myocarditis was not suspected clinically, and the diagnosis was made postmortem. Histology revealed intense eosinophilic infiltration of the endomyocardium with eosinophil degranulation and myocyte damage, Clinically, death in both cases was due to cardiac failure. When suspected early, appropriate management may be lifesaving.
Chikwava
Kudakwashe R
KR
Department of Pathology, Children's Hospital of Pittsburgh, 3705 Fifth Avenue, Pittsburgh, PA 15213, USA.
Savell
Van H
VH
Boyd
Theonia K
TK
D000208:Acute Disease; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D002506:Cephalexin / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D004342:Drug Hypersensitivity / Q000209:etiology* / Q000473:pathology; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D032342:Muscle Cells / Q000473:pathology; D009205:Myocarditis / Q000139:chemically induced* / Q000473:pathology; D009336:Necrosis
D000900:Anti-Bacterial Agents; D002506:Cephalexin