Multiparametric iterative self-organizing data analysis of ischemic lesions using pre- or post-Gd T1 MRI.
BACKGROUND
The purpose of this work was to evaluate effects of Gd-diethylenetriaminepentacetic acid (DTPA) injection on T(1)-weighted images of stroke and lesion segmentation and characterization results generated by our multiparametric iterative self-organizing data (ISODATA) method. The post-Gd image incorporates vasculature information into the analysis.


METHODS
Either a pre-Gd T(1)-weighted image (T1WI) or a post-Gd T1WI was used along with diffusion-, T(2)- and proton-density-weighted images in the analysis. ISODATA is a data-driven method that segments and characterizes tissue damage in stroke using multiparametric MRI.


RESULTS
Experimental results in both animal and human studies showed that the use of post-Gd T1WI modified the segmentation and characterization results on the periphery of the lesion. The peripheral region that changes with Gd-DTPA has a higher permeability compared to the rest of the lesion. Either of the data sets (including pre- or post-Gd T1WI) was used to estimate the tissue recovery and generated consistent results.


CONCLUSIONS
This study shows that our multiparametric ISODATA approach consistently identifies and characterizes the core of the ischemic lesion. It also shows that the inclusion of post-Gd T1WI results in the segmentation and characterization of the lesion periphery if it has a higher permeability compared to the rest of the lesion. Finally, it confirms that the multiparametric ISODATA MRI characterizes tissue damage and recovery in stroke.
Soltanian-Zadeh
Hamid
H
Image Analysis Laboratory, Department of Radiology, Henry Ford Health System, Detroit, MI 48202, USA. hamids@rad.hfh.edu
Bagher-Ebadian
Hassan
H
Ewing
James R
JR
Mitsias
Panayiotis D
PD
Kapke
Alissa
A
Lu
Mei
M
Jiang
Quan
Q
Patel
Suresh C
SC
Chopp
Michael
M
D000465:Algorithms; D000818:Animals; D002545:Brain Ischemia / Q000150:complications*; D016000:Cluster Analysis; D003287:Contrast Media; D038524:Diffusion Magnetic Resonance Imaging; D004195:Disease Models, Animal; D017352:Echo-Planar Imaging; D019786:Gadolinium DTPA; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008297:Male; D008824:Michigan; D011237:Predictive Value of Tests; D051381:Rats; D017208:Rats, Wistar; D012042:Registries; D012720:Severity of Illness Index; D020521:Stroke / Q000209:etiology / Q000473:pathology*; D013997:Time Factors
D003287:Contrast Media; D019786:Gadolinium DTPA