Impact of infertility drugs after treatment of borderline ovarian tumors: results of a retrospective multicenter study.
OBJECTIVE
To evaluate safety and fertility outcome after the use of infertility drugs in patients who were treated conservatively for a borderline ovarian tumor (BOT).


METHODS
A retrospective multicenter study.


METHODS
Centers participating in the French National Register on In Vitro Fertilization registry.


METHODS
Thirty patients who were treated for BOT who underwent ovarian induction (OI).


METHODS
Ovarian induction was performed in 25 patients for infertility after conservative surgery and before surgery for recurrent disease in 5 patients with a single ovary (emergency cases).


METHODS
Fertility and recurrences rates.


RESULTS
The mean number of cycles of OI per patient was 2.6 (range, 1-10 cycles). The median follow-up time after treatment of the BOT was 93 months (range, 26-276 months). After a median follow-up time of 42 months after OI, 4 recurrences were observed (initial management was simple cystectomy in 3 of them). All recurrences were borderline tumors on a remaining ovary that had been treated by surgery alone. All patients are currently disease-free. Thirteen pregnancies were observed (10 pregnancies (40%) in the group of 25 patients who were treated for infertility).


CONCLUSIONS
These results suggest that infertility drugs could be used safely in patients who experience infertility after conservative management of an early-stage BOT.
Fortin
Anne
A
Department of Obstetrics and Gynecology, Centre Hospitalier Universitaire Bichat, Paris, France.
Morice
Philippe
P
Thoury
Anne
A
Camatte
Sophie
S
Dhainaut
Caroline
C
Madelenat
Patrick
P
D000293:Adolescent; D000328:Adult; D002648:Child; D002996:Clomiphene / Q000627:therapeutic use; D005260:Female; D005300:Fertility Agents, Female / Q000627:therapeutic use*; D005307:Fertilization in Vitro; D006801:Humans; D010051:Ovarian Neoplasms / Q000601:surgery*; D010062:Ovulation Induction / Q000379:methods*; D011247:Pregnancy; D018873:Pregnancy Rate; D012189:Retrospective Studies
D005300:Fertility Agents, Female; D002996:Clomiphene