Toxicoproteomics in liver injury and inflammation.
Toxicoproteomics, in applying proteomics to toxicology, seeks to identify critical proteins and pathways in biological systems responding to adverse chemical exposures and environmental stressors using global protein expression technologies. Toxicoproteomics is being exploited for the discovery of new biomarkers and toxicity signatures in target organs, such as liver, in major biological processes, such as inflammation, in mapping serum, plasma, and other biofluid proteomes, and in parallel proteomic and transcriptomic studies. The new field of toxicoproteomics is uniquely positioned toward discovery of new biomarkers and signatures of tissue injury and a better understanding of protein expression responses during toxicity and environmental disease.
Merrick
B Alex
BA
National Institute of Environmental Health Sciences, Research Triangle Park, Durham, NC 27709, USA. merrick@niehs.nih.gov
D056486:Chemical and Drug Induced Liver Injury / Q000378:metabolism* / Q000503:physiopathology; D015180:Electrophoresis, Gel, Two-Dimensional; D006801:Humans; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000503:physiopathology; D013058:Mass Spectrometry / Q000379:methods; D040901:Proteomics; D014116:Toxicology