title: [The real-time FOCSDT detection method and conditions for dissolution test of metronidazole and vitamin B6 tablets].
abstract: A method to monitor the dissolution rate of drug on-line fiber optic chemical sensor dissolution test(FOCSDT) was studied. Bifurcated optical fiber was used to connect the light source and detector, and the common end was dipped in the dissolution vessel. The dissolution process could be monitored through computer. The results show that the high, middle and low concentration group's recovery of metronidazole is 100.8%, 99.8% and 100.6%; and RSD is 2.5, 0.8 and 1.1 respectively, The high, middle and low Concentration group's recovery of vitamin B6 is 98.8%, 100.8% and 98.8%; and RSD is 4.1, 4.1 and 2.5 respectively. This process of analysis can test the whole process of drug and get dissolution graph. The study shows that this process analysis can reflect the real dissolution of drug and obtain the total information.
authors.affiliation: College of Public Health, Xinjiang Medical University, Urumqi 830054, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Wu
authors.forename: Mei
authors.initials: M
authors.lastname: Yang
authors.forename: Xin-Xia
authors.initials: XX
authors.lastname: Li
authors.forename: Jian
authors.initials: J
authors.lastname: Chen
mesh_terms: D000890:Anti-Infective Agents / Q000032:analysis / Q000737:chemistry / Q000493:pharmacokinetics; D008795:Metronidazole / Q000032:analysis / Q000737:chemistry / Q000493:pharmacokinetics*; D015394:Molecular Structure; D055100:Optical Fibers; D015203:Reproducibility of Results; D012815:Signal Processing, Computer-Assisted / Q000295:instrumentation; D013056:Spectrophotometry, Ultraviolet / Q000295:instrumentation / Q000379:methods*; D013607:Tablets; D013678:Technology, Pharmaceutical / Q000295:instrumentation / Q000379:methods*; D025101:Vitamin B 6 / Q000032:analysis / Q000737:chemistry / Q000493:pharmacokinetics*; D014803:Vitamin B Complex / Q000032:analysis / Q000737:chemistry / Q000493:pharmacokinetics
chemical_list: D000890:Anti-Infective Agents; D013607:Tablets; D014803:Vitamin B Complex; D008795:Metronidazole; D025101:Vitamin B 6