title: Managing extracavitary prosthetic vascular graft infections: a pathway to success.
abstract: Prosthetic vascular graft infections portend grave consequences if not treated expediently. Despite the low incidence of infection, the potential for limb loss or death greatly magnifies this complication. The surgical management of prosthetic graft infections has evolved over the last 2 decades. With the myriad therapeutic options now available, an algorithm is necessary to provide the optimal surgical treatment of Samson groups 1 through 5 extracavitary infected vascular prostheses. An extensive review of the literature was undertaken to evaluate the most effective management schemes. The authors found that 3 factors--Samson classification, bacteriology, and patient vascular anatomy--are vital to the surgical strategy. These 3 criteria were examined, and an algorithm was developed based on successful clinical and experimental results. This review provides a step-by-step rationale for the surgical management of extracavitary prosthetic graft infections according to the most successful reported outcomes.
authors.affiliation: Aesthetic and Plastic Surgery Institute, University of California, Irvine, Orange, CA, USA.
authors.forename: Eleonore
authors.initials: E
authors.lastname: Zetrenne
authors.forename: Garrett A
authors.initials: GA
authors.lastname: Wirth
authors.forename: Bryan C
authors.initials: BC
authors.lastname: McIntosh
authors.forename: Gregory R D
authors.initials: GR
authors.lastname: Evans
authors.forename: Deepak
authors.initials: D
authors.lastname: Narayan
mesh_terms: D000465:Algorithms; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use; D001807:Blood Vessel Prosthesis / Q000009:adverse effects*; D003131:Combined Modality Therapy; D003646:Debridement; D006801:Humans; D008272:Mafenide / Q000627:therapeutic use; D011206:Povidone-Iodine / Q000627:therapeutic use; D016459:Prosthesis-Related Infections / Q000188:drug therapy / Q000382:microbiology / Q000601:surgery*; D013524:Surgical Flaps
chemical_list: D000891:Anti-Infective Agents, Local; D008272:Mafenide; D011206:Povidone-Iodine