title: HCG--A new kid on the block in prematurity prevention.
abstract: Human chorionic gonadotropin (HCG) is a molecule with multiple endocrine, paracrine, and immunoregulatory actions. Its importance for the enhancement of fertility, successful implantation, and survival of the conceptus in early gestation is recognized. However, studies conducted worldwide in recent years indicate that HCG may also play a significant role in maintaining pregnancy well after the first trimester. Emerging evidence suggests that different biomolecular and physiologic effects of HCG are concordantly directed toward inhibition of myometrial contractility to maintain pregnancy. These studies have prompted preliminary animal and human testing of HCG for the prevention of preterm birth. This article reviews the current knowledge as well as the future perspectives on HCG as a useful new tool in prematurity prevention.
authors.affiliation: Department of Surgery, Section of Gynecology and Obstetrics, University of Rome Tor Vergata, 00133, Rome, Italy. ticconi@med.uniroma2.it
authors.forename: Carlo
authors.initials: C
authors.lastname: Ticconi
authors.forename: Emilio
authors.initials: E
authors.lastname: Piccione
authors.forename: Alessia
authors.initials: A
authors.lastname: Belmonte
authors.forename: Ch V
authors.initials: ChV
authors.lastname: Rao
mesh_terms: D006063:Chorionic Gonadotropin / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007752:Obstetric Labor, Premature / Q000517:prevention & control*; D011247:Pregnancy; D014590:Uterine Contraction / Q000187:drug effects
chemical_list: D006063:Chorionic Gonadotropin