Increased farnesylation of p21-Ras and neonatal macrosomia in women with gestational diabetes.
Six of 22 mothers with gestational diabetes mellitus had infants with macrosomia, cord blood hyperinsulinemia, and increased amounts of a key mitogenic intermediate, farnesylated p21-Ras. The ability of fetal hyperinsulinemia to increase the availability of farnesylated p21-Ras may represent one mechanism of the growth-promoting action of insulin during fetal development.
Thureen
Patti
P
Department of Pediatrics, Medicine of the University of Colorado Health Sciences Center, Research Service of the Denver Veterans Affairs Medical Center, Colorado, USA. thureen@uchsc.edu
Reece
Melanie
M
Rodden
Donna
D
Barbour
Lynn
L
Chappell
James
J
Leitner
J Wayne
JW
Jones
Richard O
RO
Draznin
Boris
B
D016640:Diabetes, Gestational / Q000378:metabolism*; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D005320:Fetal Macrosomia / Q000097:blood* / Q000378:metabolism; D006801:Humans; D007231:Infant, Newborn; D007328:Insulin / Q000097:blood*; D007962:Leukocytes / Q000737:chemistry*; D011247:Pregnancy; D017368:Protein Prenylation; D016283:Proto-Oncogene Proteins p21(ras) / Q000378:metabolism*
D007328:Insulin; D016283:Proto-Oncogene Proteins p21(ras)