Taxanes: perspectives for biotechnological production.
Taxol is a valuable plant-derived drug showing activity against various cancer types. Worldwide efforts had been made to overcome the supply problem, because the supply by isolation from the bark of the slow-growing yew trees is limited. Plant cell cultures as well as chemical and biotechnological semisynthesis are processes, which are intensively investigated for the production of taxanes paclitaxel (Taxol) and docetaxel (Taxotere) in the last few years. This article provides a comparison of the current research on taxane biosynthesis and production in yew cell cultures.
Frense
Dieter
D
Institut für Bioprozess- und Analysenmesstechnik e.V., Rosenhof, 37308, Heilbad Heiligenstadt, Germany. dieter.frense@iba-heiligenstadt.de
D001952:Bridged-Ring Compounds / Q000737:chemistry / Q000378:metabolism*; D018929:Cell Culture Techniques / Q000379:methods; D000077143:Docetaxel; D015394:Molecular Structure; D017239:Paclitaxel / Q000096:biosynthesis* / Q000737:chemistry; D043823:Taxoids / Q000737:chemistry / Q000378:metabolism*; D020946:Taxus / Q000166:cytology / Q000378:metabolism*
D001952:Bridged-Ring Compounds; D043823:Taxoids; D000077143:Docetaxel; C080625:taxane; D017239:Paclitaxel