Antihyperlipidemic effect of Aronia melanocarpa fruit juice in rats fed a high-cholesterol diet.
Aronia melanocrpa fruit juice (AMFJ) used in our experiment was very rich in phenolic substances (709.3 mg gallic acid equivalents/100 ml juice). Anthocyanins (106.8 mg cyanidin-3-glucoside equivalents/100 ml juice) were the main flavonoid group. The aim of this study was to assess the influence of AMFJ on plasma lipids and lipoprotein profile, and histopathology of liver and aorta in rats with dietary-induced hyperlipidemia. AMFJ was administered by gavage for 30 days at doses of 5, 10 and 20 ml/kg body weight to rats fed a standard diet (SD) or a 4% cholesterol-containing diet (4% ChD). The 4% ChD caused a significant elevation of plasma total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and triglycerides (TG). AMFJ did not significantly influence plasma lipids in rats fed the SD and significantly hindered the elevation of plasma TC, LDL-C and TG in rats fed the 4% ChD. High-density lipoprotein cholesterol (HDL-C) levels were not significantly influenced either by the 4% ChD or by AMFJ. Neither the cholesterol feeding, nor AMFJ treatment induced any histopathological changes in rat liver and aorta. In conclusion, AMFJ showed an antihyperlipidemic effect in rats with hyperlipidemia and could be valuable in reducing this factor of cardiovascular risk.
Valcheva-Kuzmanova
S
S
Department of Preclinical and Clinical Pharmacology and Biochemistry, Medical University, 55 Marin Drinov Str., 9002 Varna, Bulgaria. stefkavk@yahoo.com
Kuzmanov
K
K
Mihova
V
V
Krasnaliev
I
I
Borisova
P
P
Belcheva
A
A
D000284:Administration, Oral; D000818:Animals; D000872:Anthocyanins / Q000032:analysis / Q000627:therapeutic use; D001011:Aorta / Q000187:drug effects / Q000473:pathology; D002791:Cholesterol, Dietary / Q000008:administration & dosage; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D006949:Hyperlipidemias / Q000097:blood / Q000188:drug therapy*; D000960:Hypolipidemic Agents / Q000627:therapeutic use*; D008055:Lipids / Q000097:blood; D008074:Lipoproteins / Q000097:blood; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008297:Male; D010636:Phenols / Q000032:analysis / Q000627:therapeutic use; D046936:Photinia / Q000737:chemistry*; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar
D000872:Anthocyanins; D002791:Cholesterol, Dietary; D000960:Hypolipidemic Agents; D008055:Lipids; D008074:Lipoproteins; D010636:Phenols; D010936:Plant Extracts