title: Metastatic tumors in the jaws: a retrospective study of 114 cases.
abstract: BACKGROUND
  Malignancies involving the bones are metastatic tumors more commonly than primary tumors. In this retrospective study, the authors review metastatic disease in the jaws.
  
  
  METHODS
  The authors retrieved cases of metastatic disease in the jaws over a 45-year period from the pathology archives at the University of Michigan School of Dentistry, Ann Arbor, and Indiana University School of Dentistry, Indianapolis.
  
  
  RESULTS
  The authors conducted a retrospective analysis of 114 cases of metastatic disease in the jaws and found that approximately 60 percent of subjects had no history of malignancy. The sex distribution was equivalent. Mandibular predilection was more prominent in females than in males. Metastases from the breast were significantly greater than those from the lung and prostate (P < or = .05), the second and third most frequent sites, respectively. Women exhibited twice as many jaw metastases as did men 31 to 40 years of age and significantly fewer metastases than did men 71 to 80 years of age (P < or = .05).
  
  
  CONCLUSIONS
  In the majority of cases, subjects had an undiagnosed primary cancer at the time the metastatic jaw disease presented. The most common site of origin of the primary cancer was the breast, when primary sites were considered independent of sex.
  
  
  CONCLUSIONS
  Patients with metastatic disease in the jaws may have innocuous dental symptoms, such as pulpal or periodontal pain; therefore, clinicians will play a significant role in diagnosing the life-threatening disease.
authors.affiliation: Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, Michigan 48109-1078, USA. njdsilva@umich.edu
authors.forename: Nisha J
authors.initials: NJ
authors.lastname: D'Silva
authors.forename: Don-John
authors.initials: DJ
authors.lastname: Summerlin
authors.forename: Kitrina G
authors.initials: KG
authors.lastname: Cordell
authors.forename: Rafik A
authors.initials: RA
authors.lastname: Abdelsayed
authors.forename: Charles E
authors.initials: CE
authors.lastname: Tomich
authors.forename: Carl T
authors.initials: CT
authors.lastname: Hanks
authors.forename: Dalbert
authors.initials: D
authors.lastname: Fear
authors.forename: Samuel
authors.initials: S
authors.lastname: Meyrowitz
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor; D001943:Breast Neoplasms / Q000473:pathology; D005260:Female; D006801:Humans; D007573:Jaw Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000556:secondary*; D008175:Lung Neoplasms / Q000473:pathology; D008297:Male; D009382:Neoplasms, Unknown Primary; D011471:Prostatic Neoplasms / Q000473:pathology; D012189:Retrospective Studies; D012737:Sex Factors
chemical_list: D014408:Biomarkers, Tumor