Transplacental transfer of phenyltins from a pregnant Dall's porpoise (Phocoenoides dalli) to her fetus.
The maternal to fetal transfer of monophenyltin (MPT), diphenyltin (DPT), and triphenyltin (TPT) was investigated for the first time in a cetacean species, a mother-fetus pair of Dall's porpoises (Phocoenoides dalli) collected off the Sanriku coast, Japan. The mother individual was contaminated by phenyltin compounds, and the muscle, blubber, and liver accounted for 90% of the total phenyltin burden. A two-generation phenyltin contamination via transplacental transfer was demonstrated. This study revealed that the transfer rate was 0.29% for total phenyltins to a fetus of about 6-month-old. Unlike in the mother, the fetal liver could not be considered the target organ for all the phenyltins studied. In a ca. 100kg-weight mother Dall's porpoise and its fetus of 2.21kg-weight, approximately 153microg (TPT, 139microg; DPT, 9.4microg; MPT, 4.2microg) and 0.44microg of total phenyltins (TPT, 0.38microg; DPT, 0.03microg; MPT, 0.03microg) were found, respectively. The body burden of TPT consisted of 91% and 86% of the total phenyltin burdens in the maternal and fetal bodies, respectively.
Yang
Jian
J
Key Laboratory of Ecological Environment and Resources of Inland Fisheries, Freshwater Fisheries Research Center, Chinese Academy of Fishery Science, Qitang Road No. 1, Wuxi City, Jiangsu 214081,China. yangj@ori.u-tokyo.ac.jp
Harino
Hinoya
H
Miyazaki
Nobuyuki
N
D000818:Animals; D005260:Female; D008431:Maternal-Fetal Exchange; D009947:Organotin Compounds / Q000493:pharmacokinetics*; D019576:Porpoises; D011247:Pregnancy; D014018:Tissue Distribution; D014874:Water Pollutants, Chemical / Q000493:pharmacokinetics*
D009947:Organotin Compounds; D014874:Water Pollutants, Chemical; C063612:diphenyltin; C063613:phenyltin; C030665:triphenyltin