title: Positive correlation between standardized uptake values of FDG uptake in the stomach and the value of the C-13 urea breath test.
abstract: OBJECTIVE
  The distribution of FDG uptake in the stomach is variable. Gastritis is one of the causes of elevated FDG uptake. Helicobacter pylori (HP) infection was found in approximately 80% of patients with peptic ulcer and 30% to 60% of symptomatic gastritis. The C-13 urea breath test (UBT) is one of the gold standard tools in diagnosis of HP infection. The aim of this study was to assess the correlation between standardized uptake values (SUVs) of FDG uptake in the stomach and the value of the C-13 urea breath test (UBT).
  
  
  METHODS
  Sixteen patients, referred from the department of community medicine, for FDG PET for health examination were chronologically enrolled for detection of HP infection by using the C-13 UBT within 1 week. The maximal SUVs of FDG uptake in the gastric wall as well as the value of the C-13 UBT were measured. The correlation between maximal SUVs of FDG uptake in the stomach and the value of the C-13 UBT was observed.
  
  
  RESULTS
  We took the results of C-13 UBT as the final diagnosis of HP infection. Of 16 patients, 5 were HP-infected and 11 were uninfected. Standardized uptake values of FDG uptake in the gastric wall were strong positively correlated with the value of the C-13 UBT in this retrospective study (P < 0.001).
  
  
  CONCLUSIONS
  Except for gastric cancer, HP infection has to be concerned when high SUVs of FDG uptake in the stomach are noted.
authors.affiliation: Department of Nuclear Medicine and PET Center, China Medical University Hospital, Taichung, Taiwan.
authors.forename: Chun-Yi
authors.initials: CY
authors.lastname: Lin
authors.forename: Chiu-Shoung
authors.initials: CS
authors.lastname: Liu
authors.forename: Hueisch-Jy
authors.initials: HJ
authors.lastname: Ding
authors.forename: Shung-Shung
authors.initials: SS
authors.lastname: Sun
authors.forename: Kuo-Yang
authors.initials: KY
authors.lastname: Yen
authors.forename: Te-Chun
authors.initials: TC
authors.lastname: Hsieh
authors.forename: Cheng-Chieh
authors.initials: CC
authors.lastname: Lin
authors.forename: Chia-Hung
authors.initials: CH
authors.lastname: Kao
mesh_terms: D001944:Breath Tests / Q000379:methods; D002247:Carbon Isotopes; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000493:pharmacokinetics*; D005753:Gastric Mucosa / Q000378:metabolism; D005756:Gastritis / Q000175:diagnosis* / Q000378:metabolism*; D016481:Helicobacter Infections / Q000175:diagnosis* / Q000378:metabolism*; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D009928:Organ Specificity; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D013223:Statistics as Topic; D013270:Stomach / Q000000981:diagnostic imaging; D014508:Urea / Q000032:analysis
chemical_list: D002247:Carbon Isotopes; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D014508:Urea