Tetramethylpyridiniumporphyrazines--a new class of G-quadruplex inducing and stabilising ligands.
3,4-Tetramethylpyridiniumporphyrazines bind strongly and selectively to human telomeric G-quadruplex DNA, inducing the formation of an antiparallel quadruplex in a process that mimics molecular chaperones.
Gonçalves
Diana P N
DP
University Chemical Laboratory, Lensfield Road, Cambridge, UKCB2 1EW.
Rodriguez
Raphaël
R
Balasubramanian
Shankar
S
Sanders
Jeremy K M
JK
D004247:DNA / Q000737:chemistry*; D054856:G-Quadruplexes; D008024:Ligands; D008745:Methylation; D015394:Molecular Structure; D011166:Porphyrins / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry*; D013057:Spectrum Analysis
D008024:Ligands; D011166:Porphyrins; D011725:Pyridines; D004247:DNA