Complete response of highly advanced colon cancer with multiple lymph node metastases to irinotecan combined with UFT: report of a case.
Massive lymph node metastasis of the para-aortic region and supraclavicular lymph nodes, Virchow's lymph node metastasis due to colon cancer, is extremely rare. We herein report a case of such systemic lymph node metastasis that was successfully treated with a combination of irinotecan (CPT-11) and UFT, a combination drug of tegafur and uracil. The patient was a 57-year-old woman who had a tumor in the ascending colon, and massively swollen para-aortic and supraclavicular lymph node metastasis. She was treated with combination chemotherapy of CPT-11 and UFT. The main tumor was detected as a decompressed scar, and the supraclavicular and para-aortic lymph nodes had completely disappeared after the second cycle of treatment. A histopathological examination and immunohistochemistry with cytokeratin showed complete remission of adenocarcinoma in the tumor and para-aortic lymph nodes. She remains alive without recurrence 52 months after chemotherapy. Combination chemotherapy of CPT-11 and UFT may be of potential value in the treatment of advanced colorectal carcinoma, and both histopathological and immunohistochemical confirmation of a complete remission may indicate prolonged disease-free survival.
Fujie
Yujiro
Y
Department of Surgery, Graduate School of Medicine, Osaka University, Suita 565-0871, Japan.
Ikeda
Masataka
M
Seshimo
Iwao
I
Ezumi
Koji
K
Hata
Taishi
T
Shingai
Tatsushi
T
Yasui
Masayoshi
M
Takayama
Osamu
O
Fukunaga
Hiroki
H
Ikenaga
Masakazu
M
Takemasa
Ichiro
I
Yamamoto
Hirofumi
H
Ohue
Masayuki
M
Sekimoto
Mitsugu
M
Hirota
Seiichi
S
Monden
Morito
M
D000230:Adenocarcinoma / Q000175:diagnosis / Q000188:drug therapy* / Q000556:secondary; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002166:Camptothecin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D003110:Colonic Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D003113:Colonoscopy; D004791:Enzyme Inhibitors / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D000077146:Irinotecan; D008207:Lymphatic Metastasis; D008875:Middle Aged; D011355:Prodrugs; D005641:Tegafur / Q000008:administration & dosage / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed; D014498:Uracil / Q000008:administration & dosage / Q000627:therapeutic use
D004791:Enzyme Inhibitors; D011355:Prodrugs; D005641:Tegafur; D014498:Uracil; D000077146:Irinotecan; D002166:Camptothecin