[Clinical characteristics of 143 Chinese HIV/AIDS patients].
OBJECTIVE
To investigate the clinical characteristics of human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) patients in China.


METHODS
Totally 143 HIV/AIDS patients who were first diagnosed in Peking Union Medical College Hospital form January 1988 to April 2006 were enrolled in this study. Clinical characteristics were retrospectively analyzed.


RESULTS
Among 143 HIV/ AIDS patients, 57 patients had no clinical symptoms and were confirmed by routine examinations; 86 patients had clinical symptoms, including fever (n = 50), weight loss (n = 18), and discomforts involving respiratory system (n = 34), gastrointestinal system (n = 16), and derma and mucosa (n = 17). Opportunistic infections (OIs) such as pneumocystis jiroveci pneumonia (PCP) (n = 27), oropharyngeal candidiasis (n = 16), tuberculosis (n = 15) , and cytomegalovirus (CMV) infection (n = 9) were also observed in patients whose CD4 + T cell counts were less than 200/mm3. Most CMV infection and cryptococcal meningitis occurred in patients whose CD4 + T cell counts were less than 100/mm3. CD4 + T cell count was negatively correlated with plasma viral load (r = -0.420, P = 0.001).


CONCLUSIONS
Fever, dyspnea, and weight loss are the most common symptoms in the patients of this study. The respiratory system, gastrointestinal system, derma and mucosa are the most commonly affected areas by OIs, and PCP is the most common OI. The occurrence of OIs corelates with CD4 + T cell count.
Dai
Yi
Y
Department of Infectious Diseases, PUMC Hospital, CAMS and PUMC, Beijing 100730, China.
Li
Tai-sheng
TS
Wang
Ai-xia
AX
Qiu
Zhi-feng
ZF
Xie
Jing
J
Han
Yang
Y
Liu
Zheng-yin
ZY
Ma
Xiao-jun
XJ
Wang
Huan-ling
HL
Fan
Hong-wei
HW
Zuo
Ling-yan
LY
Li
Yan-ling
YL
Deng
Guo-hua
GH
Sheng
Rui-yuan
RY
D017088:AIDS-Related Opportunistic Infections / Q000276:immunology; D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000293:Adolescent; D000328:Adult; D000368:Aged; D018791:CD4 Lymphocyte Count; D002681:China; D004417:Dyspnea / Q000209:etiology; D004614:Emaciation / Q000209:etiology; D005260:Female; D005334:Fever / Q000209:etiology; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011020:Pneumonia, Pneumocystis / Q000276:immunology; D012189:Retrospective Studies