title: T-lymphocyte production, function, and death in children who recovered from opsoclonus-myoclonus syndrome.
abstract: Reduced CD4+ lymphocytes have been recently found in peripheral blood of children with active opsoclonus-myoclonus syndrome. The authors identified 2 children who recovered from this syndrome, one of whom showed reduced CD4+ lymphocytes 2 years after the disease onset. Except for a decrease of "naive" CD45RA+ CD4+ population and a mild restriction of T-cell heterogeneity in this patient, probably related to the immune response to viral infections, no alterations of T-cell homeostasis and function were found in either child. Therefore, the decrease of CD4+ cells may persist after clinical recovery, but the causes of this abnormality cannot be ascribed to intrinsic T-cell defects.
authors.affiliation: Laboratorio di Biotecnologie, Spedali Civili of Brescia, Brescia, Italy.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Sottini
authors.forename: Roberto
authors.initials: R
authors.lastname: Micheli
authors.forename: Claudia
authors.initials: C
authors.lastname: Ghidini
authors.forename: Monica
authors.initials: M
authors.lastname: Valotti
authors.forename: Paolo
authors.initials: P
authors.lastname: Airò
authors.forename: Luigi
authors.initials: L
authors.lastname: Caimi
authors.forename: Luisa
authors.initials: L
authors.lastname: Imberti
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000627:therapeutic use; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D016923:Cell Death; D049109:Cell Proliferation; D002675:Child, Preschool; D005260:Female; D006728:Hormones / Q000627:therapeutic use; D006801:Humans; D053578:Opsoclonus-Myoclonus Syndrome / Q000188:drug therapy / Q000276:immunology*
chemical_list: D006728:Hormones; D000324:Adrenocorticotropic Hormone