Tolerance to the glycopeptides vancomycin and teicoplanin in coagulase-negative staphylococci.
Tolerance to vancomycin and teicoplanin in 90 clinical isolates of coagulase-negative staphylococci (CoNS) was investigated by time-kill curve methodology. Only six strains, belonging to the Staphylococcus lugdunensis species, exhibited tolerance. The seven other S. lugdunensis strains tested displayed weak susceptibility to the bactericidal activity of glycopeptides compared to the other CoNS. These phenomena are of concern, since S. lugdunensis is recognized as one of the most pathogenic CoNS.
Bourgeois
Ingrid
I
Groupe de Recherce sur les Antimicrobiens et les Microorganismes, U.P.R.E.S. EA 2656, I.F.R. 23, Université de Rouen, and Centre Hospitalier Universitaire, Rouen, France.
Pestel-Caron
Martine
M
Lemeland
Jean-Francois
JF
Pons
Jean-Louis
JL
Caron
Francois
F
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D003030:Coagulase / Q000172:deficiency*; D004361:Drug Tolerance; D013203:Staphylococcal Infections / Q000188:drug therapy / Q000382:microbiology; D013210:Staphylococcus / Q000187:drug effects / Q000201:enzymology; D017334:Teicoplanin / Q000494:pharmacology*; D014640:Vancomycin / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D003030:Coagulase; D017334:Teicoplanin; D014640:Vancomycin