A genome-wide linkage scan for quantitative trait loci underlying obesity related phenotypes in 434 Caucasian families.
To identify quantitative trait loci (QTLs) that contribute to obesity, we performed a large-scale whole genome linkage scan (WGS) involving 4,102 individuals from 434 Caucasian families. The most pronounced linkage evidence was found at the genomic region 20p11-12 for fat mass (LOD = 3.31) and percentage fat mass (PFM) (LOD = 2.92). We also identified several regions showing suggestive linkage signals (threshold LOD = 1.9) for obesity phenotypes, including 5q35, 8q13, 10p12, and 17q11.
Zhao
Lan-Juan
LJ
Osteoporosis Research Center and Department of Biomedical Sciences, Creighton University, Omaha, NE 68131, USA.
Xiao
Peng
P
Liu
Yong-Jun
YJ
Xiong
Dong-Hai
DH
Shen
Hui
H
Recker
Robert R
RR
Deng
Hong-Wen
HW
D005190:Family; D005260:Female; D008040:Genetic Linkage; D015894:Genome, Human; D006801:Humans; D008297:Male; D009765:Obesity / Q000235:genetics*; D010641:Phenotype; D040641:Quantitative Trait Loci; D044465:White People