Tolerability of beta-blockers metabolized via cytochrome P450 2D6 is sex-dependent.
Thürmann
Petra A
PA
Haack
Sara
S
Werner
Ulrike
U
Szymanski
Jacek
J
Haase
Grit
G
Drewelow
Bernd
B
Reimann
Ilselore R
IR
Hippius
Marion
M
Siegmund
Werner
W
May
Karen
K
Hasford
Joerg
J
D000319:Adrenergic beta-Antagonists / Q000009:adverse effects / Q000378:metabolism* / Q000493:pharmacokinetics; D000368:Aged; D000369:Aged, 80 and over; D001919:Bradycardia / Q000139:chemically induced; D019389:Cytochrome P-450 CYP2D6 / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005858:Germany; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D007022:Hypotension / Q000139:chemically induced; D008137:Longitudinal Studies; D008297:Male; D008790:Metoprolol / Q000009:adverse effects / Q000378:metabolism / Q000493:pharmacokinetics; D008875:Middle Aged; D012737:Sex Factors; D013575:Syncope / Q000139:chemically induced
D000319:Adrenergic beta-Antagonists; D019389:Cytochrome P-450 CYP2D6; D008790:Metoprolol