Blinded case-control study of the relationship between human coronavirus NL63 and Kawasaki syndrome.
We conducted a blinded, case-control, retrospective study in pediatric patients hospitalized at The Children's Hospital, Denver, Colorado, to determine whether human coronavirus (HCoV)-NL63 infection is associated with Kawasaki syndrome (KS). Over the course of a 7-month period, nasopharyngeal-wash samples from 2 (7.7%) of 26 consecutive children with KS and 4 (7.7%) of 52 matched control subjects tested positive for HCoV-NL63 by reverse transcription-polymerase chain reaction. These data suggest that, although HCoV-NL63 was circulating in children in our community during the time of the study, the prevalence of infection with HCoV-NL63 was not greater in patients with KS than in control subjects.
Dominguez
Samuel R
SR
Department of Pediatrics, The Children's Hospital, University of Colorado Health Science Center, Denver, CO, USA.
Anderson
Marsha S
MS
Glodé
Mary P
MP
Robinson
Christine C
CC
Holmes
Kathryn V
KV
D016022:Case-Control Studies; D002675:Child, Preschool; D003120:Colorado / Q000453:epidemiology; D017934:Coronavirus / Q000235:genetics / Q000302:isolation & purification*; D018352:Coronavirus Infections / Q000150:complications* / Q000453:epidemiology / Q000821:virology; D005260:Female; D006776:Hospitals, Pediatric; D006801:Humans; D008297:Male; D009080:Mucocutaneous Lymph Node Syndrome / Q000453:epidemiology / Q000209:etiology* / Q000821:virology; D009305:Nasopharynx / Q000821:virology; D016133:Polymerase Chain Reaction; D015995:Prevalence; D012367:RNA, Viral / Q000235:genetics; D012189:Retrospective Studies
D012367:RNA, Viral