title: Two new dioxopiperazine derivatives, arestrictins A and B, isolated from Aspergillus restrictus and Aspergillus penicilloides.
abstract: In the course of searching for bioactive substances, two new dioxopiperazine derivatives, arestrictins A (1) and B (2), were isolated along with the known dioxopiperazine, cristatin A (3), and the known peptide, asperglucide (4), from the organic extract of the xerophilic fungi, Aspergillus restrictus and Aspergillus penicilloides. The absolute structures of 1 and 2, except for the configuration of the secondary alcohol in 1, were established by spectroscopic and chemical investigation. The absolute configuration of cristatin A (3) was also determined.
authors.affiliation: Faculty of Pharmaceutical Sciences, Hoshi University, Tokyo, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Itabashi
authors.forename: Natsuna
authors.initials: N
authors.lastname: Matsuishi
authors.forename: Tomoo
authors.initials: T
authors.lastname: Hosoe
authors.forename: Norihiro
authors.initials: N
authors.lastname: Toyazaki
authors.forename: Shun-Ichi
authors.initials: S
authors.lastname: Udagawa
authors.forename: Toshimichi
authors.initials: T
authors.lastname: Imai
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Adachi
authors.forename: Ken-Ichi
authors.initials: K
authors.lastname: Kawai
mesh_terms: D001230:Aspergillus / Q000737:chemistry*; D015394:Molecular Structure; D000077489:Piperazine; D010879:Piperazines / Q000737:chemistry*; D014364:Tryptophan / Q000031:analogs & derivatives* / Q000737:chemistry
chemical_list: D010879:Piperazines; C516810:arestrictin A; C516811:arestrictin B; D000077489:Piperazine; D014364:Tryptophan