Aplastic crisis as a complication of congenital dyserythropoietic anemia type II.
A transient aplastic crisis (TAC) is a well-known complication in all types of chronic hemolytic anemia but only 2 cases of such an event were described in congenital dyserythropoietic anemias (CDAs). Here, we report a third case, and by retrospective chart review of 78 cases we found evidence of TAC in 8 further patients with CDA II, with serological evidence of previous human parvovirus B19 (B19V) infection in all but one. Although B19V infection results in TAC in only a minority of patients with CDA, physicians responsible for these patients should be aware of such a potentially life-threatening complication. Testing for B19V-specific IgG is recommended in patients with CDA to estimate the risk of a possible future aplastic crisis.
Heimpel
H
H
Klinik für Innere Medizin III, Universitätsklinikum Ulm, Ulm, Deutschland. hermann.heimpel@uniklinik-ulm.de
Wilts
H
H
Hirschmann
W D
WD
Hofmann
W K
WK
Siciliano
R D
RD
Steinke
B
B
Wechsler
J G
JG
D000293:Adolescent; D000328:Adult; D000368:Aged; D000742:Anemia, Dyserythropoietic, Congenital / Q000150:complications*; D000914:Antibodies, Viral / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008875:Middle Aged; D010322:Parvoviridae Infections / Q000097:blood / Q000150:complications; D016732:Parvovirus B19, Human / Q000276:immunology; D012010:Red-Cell Aplasia, Pure / Q000209:etiology*
D000914:Antibodies, Viral