Are there different mechanisms of synchronization in the course of spike-wave discharges (SWDs) burst development in WAG/Rij rats?
In WAG/Rij rats the pair linear correlation r was calculated for bipolar recordings in fronto-temporal, fronto-occipital and occipito-temporal zones of both hemispheres as well as in paleocerebellar cortex (culmen). It was shown that development of SWD bursts resulted in interhemispheric decreases of correlation between the right occipito-temporal cortical region on one side, and left fronto-temporal on the contralateral side. Towards the end of SWD, we found an increased interhemispheric correlation between left fronto-temporal and right fronto-occipital cortical zones, as well as, between both fronto-temporal zones. Paleocerebellum correlates at a weak to moderate level during different periods of SWD burst generation.
Godlevsky
Leonid S
LS
Odessa State Medical University, Vallehovsky Lane, 65026 Odessa, Ukraine. godlevsky@odmu.od.ua.
Vostrov
Georgy N
GN
Kobolev
Evgeny V
EV
van Luijtelaar
E L J M
ELJM
Coenen
A M L
AML
Iorhachova
Mariana N
MN
Pereverzev
Vladimir A
VA
Smirnov
Igor V
IV
D000704:Analysis of Variance; D000818:Animals; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000503:physiopathology*; D003344:Cortical Synchronization; D004827:Epilepsy / Q000235:genetics / Q000503:physiopathology*; D005260:Female; D007839:Functional Laterality; D016014:Linear Models; D008297:Male; D051381:Rats; D011922:Rats, Mutant Strains