title: The relationship between melanoma thickness and time to diagnosis in a large population-based study.
abstract: OBJECTIVE
  To examine the relationship between melanoma thickness and reported time from first recognition and from first physician contact to the diagnosis of invasive melanoma.
  
  
  METHODS
  Telephone survey of patients recently diagnosed as having melanoma, combined with relevant pathological data (including melanoma thickness and morphologic structure) from the population-based Queensland Cancer Registry. A test-retest study (n = 176) was also conducted.
  
  
  METHODS
  Population-based study in Queensland.
  
  
  METHODS
  Residents of Queensland (n = 3772) who had been diagnosed as having invasive melanoma between January 1, 2000, and December 31, 2003.
  
  
  METHODS
  Prepresentation time (time between first noticing a suspicious spot and the first physician visit), postpresentation time (time between the first physician visit and diagnosis), and total time to diagnosis (time from initial detection of the melanoma to diagnosis).
  
  
  RESULTS
  With 1 exception, we found no significant association between melanoma thickness and reported time to diagnosis for all melanomas combined, superficial spreading melanomas, or nodular melanomas. The exception was a positive association between melanoma thickness and postpresentation delay of physician-detected nodular melanomas. The reliability study gave intraclass correlation coefficients of 0.85 to 0.90 for the measures of intervals.
  
  
  CONCLUSIONS
  This large study demonstrates no clear relationship between the melanoma thickness when diagnosed and the time from first recognition of changes or from first physician examination to diagnosis. This may be because of varying biological characteristics of melanomas, as well as methodological limitations of retrospective studies when trying to measure this complex association.
authors.affiliation: Queensland Cancer Fund, University of Queensland, Brisbane, Australia. peterbaade@qldcancer.com.au
authors.forename: Peter D
authors.initials: PD
authors.lastname: Baade
authors.forename: Dallas R
authors.initials: DR
authors.lastname: English
authors.forename: Philippa H
authors.initials: PH
authors.lastname: Youl
authors.forename: Michelle
authors.initials: M
authors.lastname: McPherson
authors.forename: J Mark
authors.initials: JM
authors.lastname: Elwood
authors.forename: Joanne F
authors.initials: JF
authors.lastname: Aitken
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008545:Melanoma / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009819:Office Visits / Q000706:statistics & numerical data; D010342:Patient Acceptance of Health Care / Q000706:statistics & numerical data*; D011153:Population; D011793:Queensland / Q000453:epidemiology; D012042:Registries; D012189:Retrospective Studies; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D013997:Time Factors