Histological and immunohistological changes of the skeletal muscles in older SJL/J mice.
SJL/J mice have been studied as the model animals for autoimmunological diseases. Recently it was clarified that SJL/J mice have a defect of dysferlin. Human limb girdle muscular dystrophy 2B and Miyoshi myopathy also have a defect of dysferlin. In this study we present the histological and immunohistological changes in the natural course. Histological study revealed that SJL/J mice had inflammatory, degenerative changes, and neurogenic changes in later ages. As for interstitial inflammatory cells, the macrophages were dominant in any age, and in the T cell subset, the CD4+ T cells were more abundant than the CD8+ T cells, and few B cells were seen. The laboratory data showed a high level of creatine kinase in all ages. It is suspected that the inflammatory changes were induced by the primary immunological abnormality or by the defect of dysferlin in SJL/J mice.
Nemoto
Hiroshi
H
Department of Internal Medicine, Division of Neurology, Toho University Ohashi Medical Center, Tokyo, Japan. nemoto33@med.toho-u.ac.jp
Konno
Shingo
S
Nakazora
Hiroshi
H
Miura
Hiroko
H
Kurihara
Teruyuki
T
D000375:Aging; D000818:Animals; D015703:Antigens, CD / Q000378:metabolism; D001327:Autoimmune Diseases / Q000276:immunology / Q000378:metabolism* / Q000473:pathology*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D003402:Creatine Kinase / Q000097:blood; D000073939:Dysferlin; D007150:Immunohistochemistry; D007249:Inflammation / Q000276:immunology; D008565:Membrane Proteins / Q000172:deficiency; D051379:Mice; D008815:Mice, Inbred Strains; D018482:Muscle, Skeletal / Q000276:immunology / Q000378:metabolism* / Q000473:pathology*; D009137:Muscular Dystrophy, Animal / Q000378:metabolism / Q000473:pathology
D015703:Antigens, CD; C497505:Dysf protein, mouse; D000073939:Dysferlin; D008565:Membrane Proteins; D003402:Creatine Kinase