Mesial temporal inhibition in a patient with deep brain stimulation of the anterior thalamus for epilepsy.
We investigated the electrophysiological effects of high-frequency anterior thalamic deep brain stimulation using intracerebral mesial and lateral temporal depth electrodes in a patient with intractable focal epilepsy. Monopolar and bipolar stimulation delivered to the thalamic anterior nucleus using the programmable ITREL II stimulation device led to a significant decrease of cross power spectral density and a nonsignificant decrease of coherence in ipsilateral hippocampal structures. No such effect was found in lateral temporal or contralateral sites. The hippocampal inhibition was clearly related to the voltage (> or =7 V) and frequency (> or =70 Hz) of the thalamic stimulus and occurred with a delay of approximately 60 s after stimulus onset.
Zumsteg
Dominik
D
Krembil Neuroscience Centre, Toronto Western Hospital, University of Toronto, Toronto, Canada. dzumsteg@uhnres.utoronto.ca
Lozano
Andres M
AM
Wennberg
Richard A
RA
D000328:Adult; D020643:Anterior Thalamic Nuclei / Q000502:physiology; D001931:Brain Mapping / Q000379:methods; D046690:Deep Brain Stimulation / Q000379:methods* / Q000706:statistics & numerical data; D004567:Electrodes, Implanted; D004569:Electroencephalography / Q000379:methods / Q000706:statistics & numerical data*; D004828:Epilepsies, Partial / Q000175:diagnosis / Q000628:therapy*; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006624:Hippocampus / Q000502:physiology; D006801:Humans; D009433:Neural Inhibition / Q000502:physiology*; D011300:Preoperative Care; D013702:Temporal Lobe / Q000502:physiology*; D013788:Thalamus / Q000502:physiology*; D016896:Treatment Outcome