[The ubiquitin-proteasome proteolytic pathway and tumorigenesis].
The ubiquitin-proteasome proteolytic pathway, a major pathway for protein degradation in cells, plays a critical role in the protein metabolism. So abnormality of the ubiquitin-proteasome proteolytic pathway is closely related to many diseases, especially cancer. In this paper, we reviewed the study of the significant role of the ubiquitin-proteasome proteolytic pathways during the cell cycle, DNA repair and apoptosis, especially the relationship between these pathways and tumorigenesis.
Li
Yan-Feng
YF
Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 10005, China. lyf0222@126.com
Zhang
Qiang
Q
Zhu
Da-Hai
DH
D017209:Apoptosis; D002453:Cell Cycle; D004260:DNA Repair; D006801:Humans; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology*; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism*; D025801:Ubiquitin / Q000378:metabolism*
D025801:Ubiquitin; D046988:Proteasome Endopeptidase Complex