title: Three-year antipsychotic effectiveness in the outpatient care of schizophrenia: observational versus randomized studies results.
abstract: Antipsychotic discontinuation rates are a powerful indicator of medication effectiveness in schizophrenia. We examined antipsychotic discontinuation in the Schizophrenia Outpatient Health Outcomes (SOHO) study, a 3-year prospective, observational study in outpatients with schizophrenia in 10 European countries. Patients (n=7728) who started antipsychotic monotherapy were analyzed. Medication discontinuation for any cause ranged from 34% and 36% for clozapine and olanzapine, respectively, to 66% for quetiapine. Compared to olanzapine, the risk of treatment discontinuation before 36 months was significantly higher for quetiapine, risperidone, amisulpride, and typical antipsychotics (oral and depot), but similar for clozapine. Longer medication maintenance was associated with being socially active and having a longer time since first treatment contact for schizophrenia, whereas higher symptom severity, treatment with mood stabilizers, substance abuse, having hostile behaviour were associated with lower medication maintenance. Antipsychotic maintenance in SOHO was higher than the results of previous randomized studies.
authors.affiliation: San Joan de Déu-Serveis de Salut Mental, Fundació Sant Joan de Déu, Dr. Antoni Pujades, 42, 08830 Sant Boi de Llobregat, Barcelona, Spain. jmharo@comb.es
authors.forename: Josep Maria
authors.initials: JM
authors.lastname: Haro
authors.forename: David
authors.initials: D
authors.lastname: Suarez
authors.forename: Diego
authors.initials: D
authors.lastname: Novick
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Brown
authors.forename: Judith
authors.initials: J
authors.lastname: Usall
authors.forename: Dieter
authors.initials: D
authors.lastname: Naber
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D019370:Observation; D017063:Outcome Assessment, Health Care; D010045:Outpatients; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000188:drug therapy* / Q000453:epidemiology
chemical_list: D014150:Antipsychotic Agents