Scintigraphic imaging with a peptide glucuronide in rabbits: 99mTc- exorphin C glucuronide.
A peptide glucuronide (Exorphin C glucuronide) was labeled with 99mTc using glucoheptonate (GH) as a bifunctional chelating agent. Scintigraphic imaging was performed in male Albino rabbits. Exorphin C glucuronide showed rapid and efficient labeling with 99mTc using glucoheptonate as a bifunctional chelate. Results demonstrated that 99mTc-GEG may be a useful new type of glucuronide derivative of peptides for diagnosis of some cancer diseases.
Ertay
T
T
Dokuz Eylül University, Medical School, Department of Nuclear Medicine, Inciralti, Turkey. turkan.ertay@deu.edu.tr
Unak
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P
Biber
F Z
FZ
Tasci
C
C
Zihnioğlu
F
F
Durak
H
H
D000818:Animals; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism; D005260:Female; D020719:Glucuronides / Q000493:pharmacokinetics*; D006454:Hemoglobins / Q000493:pharmacokinetics*; D066298:In Vitro Techniques; D008297:Male; D008861:Microsomes / Q000378:metabolism; D008862:Microsomes, Liver / Q000378:metabolism; D015609:Organotechnetium Compounds / Q000493:pharmacokinetics*; D010446:Peptide Fragments / Q000493:pharmacokinetics*; D011817:Rabbits; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics*; D051381:Rats; D017208:Rats, Wistar; D011957:Receptors, Opioid / Q000378:metabolism*; D013400:Sugar Acids / Q000737:chemistry; D013667:Technetium; D014018:Tissue Distribution
D020719:Glucuronides; D006454:Hemoglobins; D015609:Organotechnetium Compounds; D010446:Peptide Fragments; D019275:Radiopharmaceuticals; D011957:Receptors, Opioid; D013400:Sugar Acids; C111722:exorphin C; C518966:technetium 99m exorphin C glucuronide; D013667:Technetium; C007852:alpha-glucoheptonic acid