title: Eicosanoid imbalance in the NOD mouse is related to a dysregulation in soluble epoxide hydrolase and 15-PGDH expression.
abstract: Eicosanoids promote or resolve inflammation depending on the class produced. Macrophage from nonobese diabetic (NOD) mouse produce increased proinflammatory lipid mediators and low levels of antiinflammatory lipoxin A4 (LXA4). The enhanced proinflammatory eicosanoids is secondary to increased cyclooxygenase-2 (Cox-2) expression and low levels of prostaglandin/leukotriene catabolic enzyme, 15-hydroxyprostaglandin dehydrogenase (15-PGDH). Deficient LXA4 production is not due to deficient lipoxygenase (LO) activity, but is related to increased soluble epoxide hydrolase (sEH), involved in metabolism of anti-inflammatory epoxyeicosatrienoic acids (EET). These aberrations in eicosanoid biology suggest that inflammation in the NOD mouse is likely to be prolonged and robust and may contribute to type 1 diabetes (T1D) pathogenesis.
authors.affiliation: Department of Pathology, Immunology, and Laboratory Medicine, College of Medicine, University of Florida, 1600 SW Archer Road No. D11-41, Gainesville, FL 32610, USA. rodrigm@pathology.ufl.edu
authors.forename: Michelle
authors.initials: M
authors.lastname: Rodriguez
authors.forename: Michael
authors.initials: M
authors.lastname: Clare-Salzler
mesh_terms: D000818:Animals; D001854:Bone Marrow Cells / Q000166:cytology / Q000378:metabolism; D002478:Cells, Cultured; D051546:Cyclooxygenase 2 / Q000096:biosynthesis; D015777:Eicosanoids / Q000276:immunology* / Q000378:metabolism; D004851:Epoxide Hydrolases / Q000032:analysis / Q000276:immunology* / Q000378:metabolism; D006911:Hydroxyprostaglandin Dehydrogenases / Q000032:analysis / Q000276:immunology* / Q000378:metabolism; D008070:Lipopolysaccharides / Q000494:pharmacology; D044045:Lipoxins / Q000096:biosynthesis; D008264:Macrophages / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D016688:Mice, Inbred NOD; D012995:Solubility
chemical_list: D015777:Eicosanoids; D008070:Lipopolysaccharides; D044045:Lipoxins; C040527:lipoxin A4; D006911:Hydroxyprostaglandin Dehydrogenases; C035859:15-hydroxyprostaglandin dehydrogenase; D051546:Cyclooxygenase 2; D004851:Epoxide Hydrolases