[Reibergram for C3c intrathecal synthesis evaluation].
BACKGROUND
Reiber's quotient diagram or reibergram has a growing apply for characterize the intratecal synthesis of proteins. Firstly reibergrama was used for the major classes of immunoglobulins but later it was used to evaluate other proteins based on the theory about molecular flux/cerebrospinal fluid (CSF) flow rate.


METHODS
C3c is a degradation product of complement factor C3 with 145 KDa and approaches to IgG molecular characteristics according with Fick's diffusion laws. It was assumed IgG constants and graphic for IgG constants and graphic to evaluate the intrathecal synthesis of C3c. Twenty-seven patients and 27 controls were studied. Serum and CSF C3c and albumin were quantified by immunodiffusion.


RESULTS
The patients with the C3c proposed reibergram were evaluated. It has been proved its validity under several CSF blood barrier conditions.


CONCLUSIONS
Reibergram for C3c can be used for the evaluation of the intrathecal synthesis of this protein.
Dorta-Contreras
Alberto Juan
AJ
Laboratorio Central Liquido Cefalorraquideo (LABCEL), Ciudad de La Habana, Cuba. adorta@infomed.sld.cu
Noris-García
Elena
E
Padilla-Docal
Bárbara
B
Rodríguez-Rey
Alexis
A
Bu-Coifiu-Fanego
Raisa
R
Magraner-Tarrau
María Esther
ME
Martí-Brenes
Mauricio
M
D000328:Adult; D016022:Case-Control Studies; D002648:Child; D015932:Complement C3c / Q000096:biosynthesis / Q000134:cerebrospinal fluid*; D006801:Humans; D005779:Immunodiffusion; D007074:Immunoglobulin G / Q000096:biosynthesis / Q000134:cerebrospinal fluid*; D009391:Nephelometry and Turbidimetry; D009422:Nervous System Diseases / Q000134:cerebrospinal fluid*
D007074:Immunoglobulin G; D015932:Complement C3c