title: No association between the TPH A218C polymorphism and personality traits in Japanese healthy subjects.
abstract: It has been suggested that the central serotonergic activity is implicated in personality traits. Tryptophan hydroxylase (TPH) is the rate-limiting enzyme in serotonin synthesis. In the present study, the association between the TPH A218C polymorphism and personality traits assessed by the Temperament and Character Inventory (TCI) was examined in 345 Japanese healthy subjects. The TPH A218C polymorphism was determined by a PCR-RFLP method. There were no significant differences in the seven dimension scores of TCI among the A/A, A/C, and C/C genotype groups by the one-way ANOVA. There was a significant negative correlation between age and the NS scores. Females showed significantly higher scores of HA, RD, and ST, and significantly lower scores of SD than males. The multiple regression analysis using age, gender, and the TPH genotype as independent variables also showed no significant association between any dimension score and the genotype. The present study thus suggests that the TPH A218C polymorphism does not affect personality traits in Japanese healthy subjects.
authors.affiliation: Department of Psychiatry, Yamagata University School of Medicine, 2-2-2 Iidanishi, Yamagata-city, Yamagata 990-9585, Japan. suzukiakihito@hotmail.com
authors.forename: Akihito
authors.initials: A
authors.lastname: Suzuki
authors.forename: Takashi
authors.initials: T
authors.lastname: Fukasawa
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Shiraishi
authors.forename: Genki
authors.initials: G
authors.lastname: Ishii
authors.forename: Shingo
authors.initials: S
authors.lastname: Oshino
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Aoshima
authors.forename: Koichi
authors.initials: K
authors.lastname: Otani
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D005260:Female; D006801:Humans; D007564:Japan; D008297:Male; D010551:Personality / Q000235:genetics*; D010552:Personality Assessment; D011110:Polymorphism, Genetic / Q000235:genetics*; D012044:Regression Analysis; D014365:Tryptophan Hydroxylase / Q000235:genetics*
chemical_list: D014365:Tryptophan Hydroxylase