Low-dose P32 therapy in essential thrombocythemia.
We present a case of an 85-year-old woman with medically refractory essential thrombocythemia and subsequent venous thrombosis. She received conservative phosphorus-32 sodium phosphate therapy for 3 mCi, approximately half the usual dose. One month later, she received a second intravenous phosphorus-32 treatment of 3.5 mCi. She responded successfully to both treatments with drops in her platelet count and experienced no adverse effects. Our case is noteworthy in the effectiveness from a conservative dose while avoiding hematologic complications.
Shetty-Alva
Neetha
N
Department of Radiology, Yale New Haven Hospital, New Haven, Connecticut 06510, USA. Neetha.Shetty-Alva@yale.edu
Cheng
David W
DW
D000369:Aged, 80 and over; D001792:Blood Platelets / Q000528:radiation effects*; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D010761:Phosphorus Radioisotopes / Q000008:administration & dosage*; D010976:Platelet Count; D019275:Radiopharmaceuticals / Q000008:administration & dosage; D013920:Thrombocythemia, Essential / Q000473:pathology* / Q000532:radiotherapy*; D016896:Treatment Outcome
D010761:Phosphorus Radioisotopes; D019275:Radiopharmaceuticals