[Cellular sources of reactive oxygen and nitrogen species. Roles in signal transcription pathways].
The history of studies regarding reactive oxygen and nitrogen species (ROS/RNS) is approximatively of 50 years. ROS were shown initially for their deleterious effects on marcormolecules such as DNA and proteins, leading to deterioration of cellular functions as an oxidative stress. On the other hand, recent studies have demonstrated that ROS/RNS act as oxidative signalling in cells, resulting in various gene expressions. This brief review focuses on the main cellular origins of ERO/ERN, such as mitochondrial respiratory chain, NAD(P)H oxidase and NO synthases, and describe the modulation by the reactive species of two major signal transduction pathways, NF-KB and AP-1 pathways.
Beaudeux
J-L
JL
EA 3617 Biochimie Radicalaire et Atteintes Vasculaires, Département de Biochimie, Faculté de sciences Pharmaceutiques et Biologiques, 4, avenue de l'Observatoire, F 75006 Paris, France. jean-louis.beaudeux@univ-paris5.fr
Peynet
J
J
Bonnefont-Rousselot
D
D
Therond
P
P
Delattre
J
J
Legrand
A
A
D000818:Animals; D006801:Humans; D052247:Nitric Oxide Synthase Type II / Q000378:metabolism; D052250:Nitric Oxide Synthase Type III / Q000378:metabolism; D026361:Reactive Nitrogen Species / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*
D026361:Reactive Nitrogen Species; D017382:Reactive Oxygen Species; D052247:Nitric Oxide Synthase Type II; D052250:Nitric Oxide Synthase Type III