title: Marine sponge metabolites for the control of inflammatory diseases.
abstract: Marine organisms are a rich source of bioactive metabolites. A number of potential anti-inflammatory compounds have been isolated from marine invertebrates that exhibit phospholipase A2 inhibitory activity. A wide range of marine compounds have been investigated for their anti-inflammatory properties. Cacospongionolide B and petrosaspongiolide M are representative examples of anti-inflammatory compounds in experimental models of acute or chronic inflammation. The mechanisms of action of these compounds include phospholipase A, inhibition as well as the control of nuclear factor-B activation and inflammatory gene expression. Although many marine compounds exhibit interesting anti-inflammatory properties, few have entered clinical trials. The future development of this class of compounds as anti-inflammatory drugs requires the introduction of novel molecular targets of therapeutic relevance in addition to biotechnological approaches for the production of these molecules.
authors.affiliation: University of Valencia, Department of Pharmacology, Av Vicent Andres Estelles s/n, 46100 Burjasot, Valencia, Spain. maria.j.alcaraz@uv.es
authors.forename: Maria José
authors.initials: MJ
authors.lastname: Alcaraz
authors.forename: Miguel
authors.initials: M
authors.lastname: Payá
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004353:Drug Evaluation, Preclinical; D006801:Humans; D007249:Inflammation / Q000517:prevention & control*; D015394:Molecular Structure; D011161:Porifera / Q000737:chemistry* / Q000378:metabolism; D013678:Technology, Pharmaceutical / Q000379:methods / Q000639:trends; D016896:Treatment Outcome
chemical_list: D000893:Anti-Inflammatory Agents