title: The first infant case with hepatosplenic gammadelta T-cell lymphoma after acute disseminated encephalomyelitis (ADEM)-like exacerbation.
abstract: We report the first infant case with hepatosplenic gammadelta T-cell lymphoma after recurrent acute disseminated encephalomyelitis-like, which were rapidly resolved with steroid pulse therapy. The patient had a history of recurrent bronchitis, intractable diarrhea, and failure to thrive since 4 months of age. Immunologic analysis revealed higher percentage of circulating gammadelta T-cells with markedly reduced numbers of CD3TCRalphabetaCD8 T-cells. The patient developed gammadelta T-cell lymphoma at the age of 15 months. Clinical course of the patient suggests the importance of immunological background for the development of hepatosplenic gammadelta T-cell lymphoma.
authors.affiliation: Department of Pediatrics, School of Medicine, Tohoku University Hospital, Tohoku University, Sendai, Japan.
authors.forename: Shinichiro Y
authors.initials: SY
authors.lastname: Koga
authors.forename: Satoru
authors.initials: S
authors.lastname: Kumaki
authors.forename: Ryo
authors.initials: R
authors.lastname: Ichinohasama
authors.forename: Mitsutoshi
authors.initials: M
authors.lastname: Munakata
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Haginoya
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Ohashi
authors.forename: Yoshiko
authors.initials: Y
authors.lastname: Tanaka
authors.forename: Osamu
authors.initials: O
authors.lastname: Sakamoto
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Minegishi
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Morio
authors.forename: Kazuie
authors.initials: K
authors.lastname: Iinuma
authors.forename: Shigeru
authors.initials: S
authors.lastname: Tsuchiya
mesh_terms: D004673:Encephalomyelitis, Acute Disseminated / Q000150:complications* / Q000473:pathology; D006801:Humans; D007223:Infant; D008113:Liver Neoplasms / Q000150:complications*; D016399:Lymphoma, T-Cell / Q000150:complications* / Q000276:immunology; D008279:Magnetic Resonance Imaging; D008297:Male; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000032:analysis*; D013160:Splenic Neoplasms
chemical_list: D016692:Receptors, Antigen, T-Cell, gamma-delta