Cardiac defibrillation and the role of mechanoelectric feedback in postshock arrhythmogenesis.
Ventricular dilatation increases the defibrillation threshold (DFT). In order to elucidate the mechanisms responsible for this increase, the present article investigates changes in the postshock behavior of the myocardium upon stretch. A two-dimensional electro-mechanical model of cardiac tissue incorporating heterogeneous fiber orientation was used to explore the effect of sustained stretch on postshock behavior via (a) recruitment of mechanosensitive channels (MSC) and (b) tissue deformation and concomitant changes in tissue conductivities. Recruitment of MSC had no influence on vulnerability to electric shocks as compared to control, but increased the complexity of postshock VF patterns. Stretch-induced deformation and changes in tissue conductivities resulted in a decrease in vulnerability to electric shocks.
Gurev
Viatcheslav
V
Department of Biomedical Engineering, Johns Hopkins University, 3400 N. Charles Street, Clark Hall 201, Baltimore, MD 21218, USA.
Maleckar
Mary M
MM
Trayanova
Natalia A
NA
D001145:Arrhythmias, Cardiac / Q000503:physiopathology*; D004566:Electrodes; D018274:Electroporation; D006321:Heart / Q000503:physiopathology*; D006801:Humans