Modulation of photic response by the metabotropic glutamate receptor agonist t-ACPD.
Glutamate is the primary excitatory transmitter in the hypothalamus. It conveys photic information to the suprachiasmatic nucleus of the hypothalamus, thereby entraining the circadian clock to environmental light cycles. While ionotropic glutamate receptors have been implicated in the transduction of photic information in suprachiasmatic nucleus cells, there is evidence that metabotropic glutamate receptors play a significant modulatory role. We investigated the effects of the metabotropic glutamate agonist (+/-)-1-aminocyclopentane-trans-1,3-dicarboxylic acid (ACPD) on light-evoked phase responses in Syrian hamsters at three phase points: circadian time 6, a time when light has no effect on the circadian timing system; circadian time 13.5, when light evokes the maximum phase delay; circadian time 19, the maximum phase advance. We found that ACPD significantly increased the light-evoked phase shift at circadian time 13.5, and had no effect at other phase points tested. These data support a role for metabotropic glutamate receptors in the circadian photic signal transduction system.
Haak
Laurel L
LL
The National Academies, Washington, DC 20001, USA.
Albers
H Elliott
HE
Mintz
Eric M
EM
D000818:Animals; D002940:Circadian Rhythm / Q000187:drug effects / Q000502:physiology* / Q000528:radiation effects; D006224:Cricetinae; D004148:Dioxolanes / Q000494:pharmacology*; D018690:Excitatory Amino Acid Agonists / Q000494:pharmacology; D018698:Glutamic Acid / Q000378:metabolism*; D008027:Light; D055537:Light Signal Transduction / Q000187:drug effects / Q000502:physiology* / Q000528:radiation effects; D008297:Male; D008647:Mesocricetus; D009434:Neural Pathways / Q000033:anatomy & histology / Q000187:drug effects / Q000378:metabolism; D011687:Purines / Q000494:pharmacology*; D018094:Receptors, Metabotropic Glutamate / Q000819:agonists / Q000378:metabolism*; D013493:Suprachiasmatic Nucleus / Q000033:anatomy & histology / Q000187:drug effects / Q000378:metabolism*
D004148:Dioxolanes; D018690:Excitatory Amino Acid Agonists; D011687:Purines; D018094:Receptors, Metabotropic Glutamate; C104068:4-(2-amino-6-chloro-9H-purin-9-yl)-1,3-dioxolane-2-methanol; D018698:Glutamic Acid