[Effect of biminne on vascular permeability of nasal mucosa in allergic rhinitis rats].
OBJECTIVE
To investigate whether the effect of Biminne on allergic rhinitis (AR) was through improving vascular permeability of nasal mucosa.


METHODS
Rat's model in Biminne-treated group and model group was induced by intraperitoneal injection of ovalbumin (OVA) and aluminum hydroxide gel suspension Biminne-treated rats were orally given Biminne suspension from the 8th day to the 17th day. On the 18th day, Evan's blue dye (EBD) in the nasal perfusate was detected to assess the vascular permeability.


RESULTS
EBD concentration was higher in the model rats than that in the normal rats, and lower in the Biminne-treated rats than that in the model rats (both P < 0.01).


CONCLUSIONS
Biminne could improve vascular permeability of nasal mucosa in sensitized rats, which may be the mechanism of its clinical effect on AR.
Gu
Yi-feng
YF
institute of Integrated Chinese and Western Medicine, Huashan Hospital, Fu- dan University, Shanghai.
Zhang
Xin-min
XM
Hu
Guo-rang
GR
D000818:Animals; D018926:Anti-Allergic Agents / Q000494:pharmacology; D002199:Capillary Permeability / Q000187:drug effects*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D008297:Male; D009297:Nasal Mucosa / Q000098:blood supply*; D010047:Ovalbumin / Q000008:administration & dosage / Q000633:toxicity; D051381:Rats; D011914:Rats, Inbred BN; D012221:Rhinitis, Allergic, Perennial / Q000139:chemically induced / Q000503:physiopathology*
D018926:Anti-Allergic Agents; D004365:Drugs, Chinese Herbal; C526710:biminne; D010047:Ovalbumin