FDG PET/CT flip flop phenomenon in treated lymphoma of bone.
A 47-year-old man with primary large B-cell lymphoma of bone underwent an F-18 fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) scan for staging. The study demonstrated multiple areas of uptake consistent with osseous lymphoma. After multiple cycles of chemotherapy, a follow-up study demonstrated a dramatic flip flop appearance in which the previously noted areas of osseous lymphoma were photopenic and normal marrow appeared to have increased activity. This flip flop appearance could incorrectly suggest lymphomatous infiltration of normal marrow.
Lin
Eugene C
EC
Virginia Mason Medical Center, Division of Nuclear Medicine, Seattle, Washington 98111, USA. radecl@vmmc.org
D000970:Antineoplastic Agents / Q000627:therapeutic use; D019046:Bone Marrow Neoplasms / Q000175:diagnosis; D001859:Bone Neoplasms / Q000175:diagnosis* / Q000188:drug therapy; D005189:False Positive Reactions; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008223:Lymphoma / Q000175:diagnosis* / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals; D013382:Subtraction Technique; D014057:Tomography, X-Ray Computed / Q000379:methods*
D000970:Antineoplastic Agents; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18