title: S-chiral sulfinamides as highly enantioselective organocatalysts.
abstract: Easily accessible chiral sulfinamide 2 has been developed as the first highly efficient and enantioselective organocatalyst relying solely on a chiral sulfur center for stereochemical induction. In the presence of 20 mol % of 2, a broad range of N-aryl ketimines 1 were reduced by trichlorosilane to produce amines 3 in high yield and enantioselectivity. [reaction: see text]
authors.affiliation: Natural Products Research Center, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China.
authors.forename: Dong
authors.initials: D
authors.lastname: Pei
authors.forename: Zhouyu
authors.initials: Z
authors.lastname: Wang
authors.forename: Siyu
authors.initials: S
authors.lastname: Wei
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
authors.forename: Jian
authors.initials: J
authors.lastname: Sun
mesh_terms: D000588:Amines / Q000737:chemistry; D002384:Catalysis; D007202:Indicators and Reagents; D013237:Stereoisomerism; D013452:Sulfonium Compounds / Q000138:chemical synthesis*; D013455:Sulfur / Q000737:chemistry
chemical_list: D000588:Amines; D007202:Indicators and Reagents; D013452:Sulfonium Compounds; D013455:Sulfur