title: Experimental Infections in dogs with Ehrlichia canis strain Borgo 89.
abstract: This study attemps to clarify the virulence and the pathogenicity of the Borgo 89 strain of Ehrlichia canis isolated from a sick dog in Corsica (France). Four unscathed beagles were intravenously injected with an inoculum of leukocytes infected with the Borgo 89 strain and the animals were examined daily for clinical signs of disease, and blood samples were drawn at frequent intervals for biochemical and hematologic assessment. Serologic (IFI) and PCR assays were also carried out. The results at autopsy are presented in this paper, leading to the conclusion that the Borgo 89 strain has a pathogenicity comparable to that of the known strains. However, the discovery of a case of completely unapparent infection raises the question of a possible individual immunization whose origin remains unexplained.
authors.affiliation: Direction Régionale du Service de Santé des Armées, BP 16, 69998 Lyon Armées, France.
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Jouret-Gourjault
authors.forename: Daniel
authors.initials: D
authors.lastname: Parzy
authors.forename: Bernard
authors.initials: B
authors.lastname: Davoust
mesh_terms: D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood; D004195:Disease Models, Animal; D004283:Dog Diseases / Q000175:diagnosis / Q000382:microbiology* / Q000503:physiopathology; D004285:Dogs; D041061:Ehrlichia canis / Q000235:genetics / Q000472:pathogenicity*; D016873:Ehrlichiosis / Q000175:diagnosis / Q000503:physiopathology / Q000662:veterinary*; D016133:Polymerase Chain Reaction
chemical_list: D000907:Antibodies, Bacterial