title: Malignant transformation of high-grade astrocytoma associated with neurocysticercosis in a patient with Turcot syndrome.
abstract: A 45-year-old woman with anaplastic astrocytoma was clinically diagnosed with Turcot syndrome, and subsequently developed simultaneous neurocysticercosis and malignant transformation to glioblastoma. The parasitic cysts and glioblastoma were microsurgically removed. Histological examination of surgical specimens revealed neurocysticercosis between the normal brain tissue and glioblastoma. The clinical course and histological findings suggest that the parasitic infection and/or genetic changes contributed to the malignant transformation of the astrocytic tumour.
authors.affiliation: Department of Neurosurgery, Tohoku University Graduate School of Medicine, 1-1, Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan.
authors.forename: Kuniyasu
authors.initials: K
authors.lastname: Niizuma
authors.forename: Miki
authors.initials: M
authors.lastname: Fujimura
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Kumabe
authors.forename: Tominaga
authors.initials: T
authors.lastname: Tominaga
mesh_terms: D001254:Astrocytoma / Q000150:complications / Q000473:pathology* / Q000601:surgery; D001932:Brain Neoplasms / Q000150:complications / Q000473:pathology* / Q000601:surgery; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D017809:Fatal Outcome; D005260:Female; D005909:Glioblastoma / Q000150:complications / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D020019:Neurocysticercosis / Q000469:parasitology / Q000473:pathology* / Q000601:surgery; D019635:Neurosurgical Procedures