Enriching chemical space with diversity-oriented synthesis.
The search for new molecular entities in drug discovery and chemical genetic programs requires the screening of high-quality collections of structurally diverse small molecules. The design and synthesis of such collections remains a major challenge to synthetic chemists. Recent strategies and results are presented in the context of the chemical space being interrogated.
Thomas
Gemma L
GL
Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.
Wyatt
Emma E
EE
Spring
David R
DR
D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D015195:Drug Design; D008956:Models, Chemical; D015394:Molecular Structure