title: Stimuli-responsive hydrogels based on polysaccharides incorporated with thermo-responsive polymers as novel biomaterials.
abstract: In recent years, intelligent hydrogels which can change their swelling behavior and other properties in response to environmental stimuli such as temperature, pH, solvent composition and electric fields, have attracted great interest. The hydrogels based on polysaccharides incorporated with thermo-responsive polymers have shown unique properties such as biocompatibility, biodegradability, and biological functions in addition to the stimuli-responsive characters. These "smart" hydrogels exhibit single or multiple stimuli-responsive characters which could be used in biomedical applications, including controlled drug delivery, bioengineering or tissue engineering. This review focuses on the recent developments and future trends dealing with stimuli-responsive hydrogels based on grafting/blending of polysaccharides such as chitosan, alginate, cellulose, dextran and their derivatives with thermo-sensitive polymers. This review also screens the current applications of these hydrogels in the fields of drug delivery, tissue engineering and wound healing.
authors.affiliation: 3B's Research Group - Biomaterials, Biodegradables and Biomimetics, University of Minho, Campus of Gualtar, 4710-057 Braga, Portugal.
authors.forename: Mani
authors.initials: M
authors.lastname: Prabaharan
authors.forename: João F
authors.initials: JF
authors.lastname: Mano
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry* / Q000627:therapeutic use; D016503:Drug Delivery Systems / Q000379:methods; D020100:Hydrogels / Q000737:chemistry* / Q000627:therapeutic use; D011134:Polysaccharides / Q000737:chemistry* / Q000627:therapeutic use; D023822:Tissue Engineering / Q000379:methods; D014945:Wound Healing / Q000187:drug effects
chemical_list: D001672:Biocompatible Materials; D020100:Hydrogels; D011134:Polysaccharides