title: Simultaneous diagnosis of CD3+ T-cell large granular lymphocyte leukaemia and true thymic hyperplasia.
abstract: CD3+ T-cell large granular lymphocyte (LGL) leukaemia is a mature T-cell neoplasm of cytotoxic T-lymphocytes. Neutropenia represents the most frequent peripheral blood cytopenia associated with CD3+ T-cell LGL leukaemia. A wide variety of diseases associated with LGL leukaemia have been reported, both autoimmune and neoplastic. We describe for the first time the association of true thymic hyperplasia with CD3+ T-cell line LGL leukaemia. The patient presented with severe symptomatic neutropenia. Complete and persistent haematological and molecular remission was induced with an association of low-dose methotrexate and cyclosporin A, followed by thymectomy.
authors.affiliation: Division of Hematology, Department of Clinical and Experimental Medicine & IRCAD, Amedeo Avogadro University of Eastern Piedmont and Ospedale Maggiore della Carità, Novara, Italy. rossidav@med.unipmn.it
authors.forename: Davide
authors.initials: D
authors.lastname: Rossi
authors.forename: Silvia
authors.initials: S
authors.lastname: Franceschetti
authors.forename: Daniela
authors.initials: D
authors.lastname: Capello
authors.forename: Annarita
authors.initials: A
authors.lastname: Conconi
authors.forename: Caterina
authors.initials: C
authors.lastname: Casadio
authors.forename: Guido
authors.initials: G
authors.lastname: Valente
authors.forename: Gianluca
authors.initials: G
authors.lastname: Gaidano
mesh_terms: D001172:Arthritis, Rheumatoid / Q000150:complications / Q000175:diagnosis; D017252:CD3 Complex / Q000378:metabolism; D003937:Diagnosis, Differential; D006801:Humans; D015458:Leukemia, T-Cell / Q000150:complications / Q000175:diagnosis* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D013952:Thymus Hyperplasia / Q000150:complications / Q000175:diagnosis*
chemical_list: D017252:CD3 Complex