Vaccination associated thrombocytopenic purpura in children.
Patients who presented with purpura and blood platelets <30x10(9)/l within 1 month after vaccination were collected from a population based material of 506 consecutive pediatric patients with newly diagnosed ITP. Of the 35 such patients, 24 had thrombocytopenia after MMR vaccination giving an estimated ITP risk of approximately 1 in 30,000 MMR inoculations. Symptoms of the 35 patients were nearly always acute. Thrombocytopenia disappeared within a month in 74% of the study patients and lasted longer than 6 months in only 10%. Bleeding episodes were uncommon during the follow-up period. We conclude that the incidence of symptomatic thrombocytopenia after vaccinations is much lower than that after respective natural infections and that the outcome in most cases is excellent.
Rajantie
J
J
Helsinki University Central Hospital, Jorvi Hospital, Finland. jukka.rajantie@hus.fi
Zeller
B
B
Treutiger
I
I
Rosthöj
S
S
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D006470:Hemorrhage; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D022542:Measles-Mumps-Rubella Vaccine / Q000009:adverse effects*; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000209:etiology* / Q000503:physiopathology; D013921:Thrombocytopenia; D014611:Vaccination
D022542:Measles-Mumps-Rubella Vaccine