Anti-influenza virus activity of biflavonoids.
Ginkgetin was found to inhibit the influenza virus sialidase. Ginkgetin-sialic acid conjugates showed a significant survival effect in the influenza-virus-infected mice.
Miki
Kazuhiko
K
Meiji Pharmaceutical University, Noshio 2-522-1, Kiyose-shi, Tokyo 204-8588, Japan.
Nagai
Takayuki
T
Suzuki
Kazushige
K
Tsujimura
Ryo
R
Koyama
Kiyotaka
K
Kinoshita
Kaoru
K
Furuhata
Kimio
K
Yamada
Haruki
H
Takahashi
Kunio
K
D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D044946:Biflavonoids / Q000494:pharmacology; D002460:Cell Line; D004285:Dogs; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005260:Female; D005419:Flavonoids / Q000494:pharmacology*; D020441:Ginkgo biloba / Q000737:chemistry; D006248:Harringtonines / Q000737:chemistry; D006801:Humans; D007202:Indicators and Reagents; D009980:Influenza A virus / Q000187:drug effects; D009981:Influenza B virus / Q000187:drug effects; D007251:Influenza, Human / Q000188:drug therapy / Q000821:virology; D051379:Mice; D008807:Mice, Inbred BALB C; D009439:Neuraminidase / Q000037:antagonists & inhibitors; D009975:Orthomyxoviridae / Q000187:drug effects* / Q000201:enzymology; D016019:Survival Analysis; D014779:Virus Replication / Q000187:drug effects
D000998:Antiviral Agents; D044946:Biflavonoids; D004791:Enzyme Inhibitors; D005419:Flavonoids; D006248:Harringtonines; D007202:Indicators and Reagents; C077458:ginkgetin; D009439:Neuraminidase