Paecilaminol, a new NADH-fumarate reductase inhibitor, produced by Paecilomyces sp. FKI-0550.
A new NADH-fumarate reductase inhibitor, paecilaminol, was isolated from the cultured broth of a fungus Paecilomyces sp. FKI-0550. It is an amino alcohol compound, the structure being established as 2-amino-14,16-dimethyl-3-octadecanol. Paecilaminol exhibited an IC50 value of 5.1 microM against Ascaris suum NADH-fumarate reductase.
Ui
Hideaki
H
Kitasato Institute for Life Sciences and Graduate School of Infection Control Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, Japan.
Shiomi
Kazuro
K
Suzuki
Hideaki
H
Hatano
Hiroko
H
Morimoto
Hiromi
H
Yamaguchi
Yuichi
Y
Masuma
Rokuro
R
Sakamoto
Kimitoshi
K
Kita
Kiyoshi
K
Miyoshi
Hideto
H
Tomoda
Hiroshi
H
Tanaka
Haruo
H
Omura
Satoshi
S
D000473:Alkanes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000818:Animals; D000969:Antinematodal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D017165:Ascaris suum / Q000187:drug effects / Q000201:enzymology; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008055:Lipids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015394:Molecular Structure; D044925:Oxidoreductases Acting on CH-CH Group Donors / Q000037:antagonists & inhibitors*; D010143:Paecilomyces / Q000378:metabolism*; D021261:Parasitic Sensitivity Tests
D000473:Alkanes; D000969:Antinematodal Agents; D004791:Enzyme Inhibitors; D008055:Lipids; C515839:paecilaminol; D044925:Oxidoreductases Acting on CH-CH Group Donors; C020155:fumarate reductase (NADH)