title: Torsades de pointes with a severely prolonged QT interval induced by an initial low dose sotalol intake.
abstract: Many drugs, including sotalol, have been implicated in prolonging QT interval and triggering torsades de pointes, a potentially fatal ventricular arrhythmia, especially during chronic therapy or in case of acute high dose toxicity. We report here a case with a severely prolonged QT interval and torsades de pointes after an initial intake of low dose sotalol (80 mg), indicating a probable inherent individual oversensitivity to sotalol.
authors.forename: Kenan
authors.initials: K
authors.lastname: Yalta
authors.forename: Okan
authors.initials: O
authors.lastname: Turgut
authors.forename: Ahmet
authors.initials: A
authors.lastname: Yilmaz
authors.forename: M Birhan
authors.initials: MB
authors.lastname: Yilmaz
authors.forename: Omer
authors.initials: O
authors.lastname: Kendirlioglu
authors.forename: Filiz
authors.initials: F
authors.lastname: Karadas
mesh_terms: D000328:Adult; D000889:Anti-Arrhythmia Agents / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008133:Long QT Syndrome / Q000139:chemically induced*; D013015:Sotalol / Q000009:adverse effects*; D016171:Torsades de Pointes / Q000139:chemically induced*
chemical_list: D000889:Anti-Arrhythmia Agents; D013015:Sotalol