title: [MUC1 (EMA): A key molecule of carcinogenesis?].
abstract: MUC1 is a large trans-membrane highly glycosylated mucin which is expressed at the apical pole of normal cells in glandular epithelia. MUC1 is implicated in many physiological mechanisms such as adhesion, development and differentiation. Also, MUC1 is frequently deregulated and over-expressed with a membrane circumferential and/or cytoplasmic expression. The intracellular tail of MUC1 is phosphorylated and can interact with many signalling proteins and transcriptional factors. Indeed, MUC1 can interact with B-catenin competitively for E-cadherin, thus destabilizing intercellular junctions and favouring metastatic dissemination. In carcinomas, the overexpression and membrane delocalization of MUC1 is associated with a worse prognosis and a shorter survival in breast, colon, kidney, prostate or gastro-intestinal cancers. MUC1 appears to be a novel therapeutic target for immunotherapy or anti-tumour vaccines.
authors.affiliation: Service d'Anatomie Pathologique, Pôle Eurasanté, Bâtiment Biologie-Pathologie, CHRU, 59037 Lille. x-leroy@chru-lille.fr
authors.forename: Xavier
authors.initials: X
authors.lastname: Leroy
authors.forename: Marie-Pierre
authors.initials: MP
authors.lastname: Buisine
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Leteurtre
authors.forename: Sebastien
authors.initials: S
authors.lastname: Aubert
authors.forename: David
authors.initials: D
authors.lastname: Buob
authors.forename: Nicole
authors.initials: N
authors.lastname: Porchet
authors.forename: Marie-Christine
authors.initials: MC
authors.lastname: Copin
mesh_terms: D000951:Antigens, Neoplasm / Q000032:analysis / Q000235:genetics / Q000502:physiology*; D014408:Biomarkers, Tumor / Q000032:analysis; D002448:Cell Adhesion; D002454:Cell Differentiation; D005260:Female; D005786:Gene Expression Regulation; D005833:Genital Neoplasms, Female / Q000473:pathology; D006031:Glycosylation; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology; D008297:Male; D018396:Mucin-1; D009077:Mucins / Q000032:analysis / Q000235:genetics / Q000502:physiology*; D009369:Neoplasms / Q000473:pathology*; D009375:Neoplasms, Glandular and Epithelial / Q000473:pathology*; D011379:Prognosis; D014571:Urologic Neoplasms / Q000473:pathology
chemical_list: D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; C060192:MUC1 protein, human; D018396:Mucin-1; D009077:Mucins