title: Clinical results of stereotactic body frame based fractionated radiation therapy for primary or metastatic thoracic tumors.
abstract: The aim of this study was to evaluate the treatment outcomes of stereotactic body radiation therapy for treating primary or metastatic thoracic tumors using a stereotactic body frame. Between January 1998 and February 2004, 101 lesions from 91 patients with thoracic tumors were prospectively reviewed. A dose of 10-12 Gy per fraction was given three to four times over consecutive days to a total dose of 30-48 Gy (median 40 Gy). The overall response rate was 82%, with 20 (22%) complete responses and 55 (60%) partial responses. The one- and two-year local progression free survival rates were 90% and 81%, respectively. The patients who received 48 Gy showed a better local tumor control than those who received less than 48 Gy (Fisher exact test; p = 0.004). No pulmonary complications greater than a RTOG toxicity criteria grade 2 were observed. The experience of stereotactic body frame based radiation therapy appears to be a safe and promising treatment modality for the local management of primary or metastatic lung tumors. The optimal total dose, fractionation schedule and treatment volume need to be determined after a further follow-up of these results.
authors.affiliation: Department of Radiation Oncology, Asan Medical Center, College of Medicine, University of Ulsan, 388-1 Pungnap-Dong, Songpa-Gu, Seoul, 138-736, Korea.
authors.forename: Sang Min
authors.initials: SM
authors.lastname: Yoon
authors.forename: Eun Kyung
authors.initials: EK
authors.lastname: Choi
authors.forename: Sang-Wook
authors.initials: SW
authors.lastname: Lee
authors.forename: Byong Yong
authors.initials: BY
authors.lastname: Yi
authors.forename: Seung Do
authors.initials: SD
authors.lastname: Ahn
authors.forename: Seong Soo
authors.initials: SS
authors.lastname: Shin
authors.forename: Heon Joo
authors.initials: HJ
authors.lastname: Park
authors.forename: Su Ssan
authors.initials: SS
authors.lastname: Kim
authors.forename: Jin-Hong
authors.initials: JH
authors.lastname: Park
authors.forename: Si Yeol
authors.initials: SY
authors.lastname: Song
authors.forename: Charn Il
authors.initials: CI
authors.lastname: Park
authors.forename: Jong Hoon
authors.initials: JH
authors.lastname: Kim
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D019583:Dose Fractionation, Radiation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography; D016634:Radiosurgery / Q000295:instrumentation*; D015996:Survival Rate; D013899:Thoracic Neoplasms / Q000601:surgery*; D016896:Treatment Outcome