Colitis in a renal transplant patient with human herpesvirus-6 infection.
A male patient developed colitis and a thrombotic microangiopathy 3 weeks after renal transplantation. Immunosuppression at the time of presentation was with sirolimus, mycophenolate mofetil, and prednisolone, but without a calcineurin inhibitor. Cytomegalovirus infection was excluded. However, human herpesvirus-6 DNA was detected at high copy number in both blood and colonic epithelium. The patient recovered after reduction in immunosuppression, with nutritional support and ganciclovir therapy.
Delbridge
M S
MS
Sheffield Kidney Institute, Sheffield, UK. Michael.Delbridge@sth.nhs.uk
Karim
M S
MS
Shrestha
B M
BM
McKane
W
W
D003092:Colitis / Q000821:virology*; D015654:Herpesvirus 6, Human / Q000302:isolation & purification*; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000209:etiology* / Q000276:immunology / Q000821:virology; D019349:Roseolovirus Infections / Q000150:complications / Q000209:etiology* / Q000276:immunology
D007166:Immunosuppressive Agents