Prenylated flavonoids from the root bark of Berchemia discolor, a Tanzanian medicinal plant.
Five new prenylated flavonoids (1-5) were isolated from the root bark of Berchemia discolor, collected in Tanzania, along with 10 known compounds, by bioactivity-guided fractionation. The structures of compounds 1-5 were elucidated using various spectroscopic techniques. Of these isolates, compound 4, and the known compounds nitidulin (6), amorphigenin (7), and dabinol (8), exhibited cytotoxic activity when evaluated against a small panel of human cancer cells. Nitidulin (6) was further tested in an in vivo hollow fiber assay and found to be active against LNCaP (human hormone-dependent prostate cancer) cells implanted intraperitoneally, at doses of 10, 20, and 40 mg/kg.
Chin
Young-Won
YW
Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, Ohio 43210, USA.
Mdee
Ladislaus K
LK
Mbwambo
Zakaria H
ZH
Mi
Qiuwen
Q
Chai
Hee-Byung
HB
Cragg
Gordon M
GM
Swanson
Steven M
SM
Kinghorn
A Douglas
AD
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D008297:Male; D015394:Molecular Structure; D024301:Plant Bark / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D011471:Prostatic Neoplasms; D027823:Rhamnaceae / Q000737:chemistry*; D013636:Tanzania
D000972:Antineoplastic Agents, Phytogenic; D005419:Flavonoids