title: Chemotherapeutic management of small bowel adenocarcinoma associated with Crohn's disease.
abstract: Four patients with metastatic primary small bowel adenocarcinoma associated with Crohn's disease were successfully treated with low dose combination chemotherapy consisting of 5-fluorouracil, leucovorin and irinotecan with or without gemcitabine. Benefits included prolonged survival, objective responses, response of resistant tumors, downstaging, and a successful secondary complete resection (Ro) with a durable remission.
authors.affiliation: Medical Oncology, Lutheran Medical Center, 150-55th St., Brooklyn, NY 11220, USA. HBRUCKNER@LMCMC.COM
authors.forename: H W
authors.initials: HW
authors.lastname: Bruckner
authors.forename: V R
authors.initials: VR
authors.lastname: Hrehorovich
authors.forename: H S
authors.initials: HS
authors.lastname: Sawhney
authors.forename: S I
authors.initials: SI
authors.lastname: Meeus
authors.forename: A M
authors.initials: AM
authors.lastname: Coopeman
mesh_terms: D000230:Adenocarcinoma / Q000150:complications / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002166:Camptothecin / Q000008:administration & dosage / Q000031:analogs & derivatives; D003424:Crohn Disease / Q000150:complications* / Q000188:drug therapy; D004379:Duodenal Neoplasms / Q000150:complications / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D005260:Female; D006801:Humans; D007078:Ileal Neoplasms / Q000150:complications / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D007421:Intestine, Small / Q000473:pathology; D000077146:Irinotecan; D007580:Jejunal Neoplasms / Q000150:complications / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D002955:Leucovorin / Q000008:administration & dosage; D008297:Male; D012074:Remission Induction; D016019:Survival Analysis
chemical_list: D000077146:Irinotecan; D002955:Leucovorin; D002166:Camptothecin