title: Development of nickel-doped lithium formate as potential EPR dosimeter for low dose determination.
abstract: EPR dosimetry employing L-alpha-alanine has been in vogue during the past few years, due to its tissue equivalence and linear dose response. However, L-alpha-alanine dosimetry has been improved during the past years, the sensitivity of this material is still too low for clinical applications. Polycrystalline lithium formate doped with NiCl2 was therefore examined for radiation response in the dose range of clinical interest (<5 Gy) using CW EPR and pulse EPR techniques. At equal and moderate settings of microwave power and modulation amplitude lithium formate doped with 1.6 wt% of NiCl2 was almost four times more sensitive compared to L-alpha-alanine, which is the most common EPR dosimeter standard. It was shown that the nickel-doped lithium formate has an excellent radiation response with a low limit of the measurable dose, and a linear dose response in the range 1-5 Gy. The relaxation and power saturation studies showed that high microwave power can be applied during measurements to improve the sensitivity of this material as an EPR dosimeter. These results show that lithium formate doped with Ni(II) exhibits promising properties required for further development of an EPR dosimeter in the dose range typical for clinical dosimetry.
authors.affiliation: Institute of Nuclear Chemistry and Technology, Dorodna 16, 03-195 Warsaw, Poland. mdan@ichtj.waw.pl
authors.forename: M
authors.initials: M
authors.lastname: Danilczuk
authors.forename: H
authors.initials: H
authors.lastname: Gustafsson
authors.forename: M D
authors.initials: MD
authors.lastname: Sastry
authors.forename: E
authors.initials: E
authors.lastname: Lund
mesh_terms: D004578:Electron Spin Resonance Spectroscopy; D005561:Formates / Q000737:chemistry*; D005609:Free Radicals / Q000737:chemistry; D008872:Microwaves; D009532:Nickel / Q000737:chemistry*; D011829:Radiation Dosage; D011874:Radiometry / Q000295:instrumentation* / Q000379:methods*; D013113:Spin Labels
chemical_list: D005561:Formates; D005609:Free Radicals; D013113:Spin Labels; C030544:formic acid; D009532:Nickel