Long-term clearance of patch-stage mycosis fungoides with the 308-nm laser.
In order to investigate the effectiveness of the 308-nm xenon chloride laser in the treatment of patch-stage mycosis fungoides that is refractory to topical steroids, we conducted a prospective, histologically controlled, open-label pilot study. Eight patients with stage 1A or 1B cutaneous T-cell lymphoma that was unresponsive to application of potent topical steroids received 20 treatments with the laser over 10 weeks and were then followed up for a minimum of 30 months. Three patients had a complete clinical and histological response and remained free of disease after 30 months A further three patients had complete clinical and histological clearance of disease, but experienced relapse within the 30 months follow-up period. One patient withdrew from the study and one had a partial response. Further research to establish the role of the 308-nm laser in the treatment of MF appears justified.
Upjohn
E
E
Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia. eupjohn@connexus.net.au
Foley
P
P
Lane
P
P
Magee
J
J
Prince
H M
HM
McCormack
C
C
Sinclair
R
R
D000293:Adolescent; D000328:Adult; D000368:Aged; D001706:Biopsy; D005260:Female; D006801:Humans; D053685:Laser Therapy / Q000379:methods*; D016410:Lymphoma, T-Cell, Cutaneous / Q000473:pathology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009182:Mycosis Fungoides / Q000473:pathology / Q000601:surgery*; D011446:Prospective Studies; D012878:Skin Neoplasms / Q000473:pathology / Q000601:surgery*; D016896:Treatment Outcome