Oral histoplasmosis after radiation therapy for laryngeal squamous cell carcinoma.
Histoplasmosis is a usually asymptomatic deep fungal infection of tropical origin with respiratory entry and possible oral, pharyngeal, or metastatic localization. The condition represents an important imported systemic mycosis with oral involvement. We report the case of a patient who developed an oropharyngeal reactivation of a latent Histoplasma infection after receiving local antitumoral radiation therapy of the neck. H capsulatum was shown to be present in the lesion by both histopathology and staining, and was deduced to be the causative organism of the disease.
Ezzedine
Khaled
K
Travel Clinics and Tropical Disease Unit, Department of Internal Medicine, Infectious Diseases and Tropical Medicine, University Hospital Center. kezzedin@ulb.ac.be
Accoceberry
Isabelle
I
Malvy
Denis
D
D000368:Aged; D000935:Antifungal Agents / Q000627:therapeutic use; D002294:Carcinoma, Squamous Cell / Q000532:radiotherapy* / Q000601:surgery; D006660:Histoplasmosis / Q000188:drug therapy / Q000209:etiology*; D006801:Humans; D017964:Itraconazole / Q000627:therapeutic use; D007822:Laryngeal Neoplasms / Q000532:radiotherapy* / Q000601:surgery; D007825:Laryngectomy; D008297:Male; D009059:Mouth Diseases / Q000209:etiology*; D011878:Radiotherapy / Q000009:adverse effects*
D000935:Antifungal Agents; D017964:Itraconazole