Donor-type myelodysplastic syndrome with t(2;3) and monosomy 7 after allogeneic peripheral blood stem cell transplantation and liver transplantation in a patient with severe-type aplastic anemia.
Secondary clonal hemaloiogical disease in donor cells has rarely been reported as a complication of allogeneic stem cell transplantation in hematological disease. We report a case of myelodysplastic syndrome that showed cytogenetic abnormalities of t(2;3) and monosomy 7, which developed 2 years after peripheral blood stem cell transplantation for aplastic anemia and 1 year after liver transplantation for drug-induced hepatic failure. This secondary malignancy of donor origin is most frequently seen in patients with leukemia. We suspect that the chromosomal abnormalities are related to hepatitis-associated aplastic anemia, administration of granulocyte colony-stimulating factor and erythropoietin for posttransplantion pancytopenia, and repeated infections after liver transplantation.
Hashino
Satoshi
S
Department of Gastroenterology and Hematology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
Fujisawa
Fumie
F
Kondo
Takeshi
T
Imamura
Masahiro
M
Sato
Kazuya
K
Torimoto
Yoshihiro
Y
Kohgo
Yutaka
Y
Kimura
Keisuke
K
Furukawa
Hiroyuki
H
Todo
Satoru
S
Asaka
Masahiro
M
D000328:Adult; D000741:Anemia, Aplastic / Q000150:complications* / Q000628:therapy*; D001782:Blood Donors; D002889:Chromosomes, Human, Pair 2; D002893:Chromosomes, Human, Pair 3; D002897:Chromosomes, Human, Pair 7; D005260:Female; D006801:Humans; D016031:Liver Transplantation / Q000009:adverse effects*; D009006:Monosomy; D009190:Myelodysplastic Syndromes / Q000209:etiology* / Q000235:genetics*; D036102:Peripheral Blood Stem Cell Transplantation / Q000009:adverse effects*; D014178:Translocation, Genetic; D014184:Transplantation, Homologous