title: Severe acute toxicity associated with high-dose methotrexate (MTX) therapy: use of therapeutic drug monitoring and test-dose to guide carboxypeptidase G2 rescue and MTX continuation.
authors.affiliation: Laboratoire de Pharmacocinétique et de Toxicocinétique, CHU Timone, 254 rue St Pierre, 13005 Marseille, France.
authors.forename: M-A
authors.initials: MA
authors.lastname: Estève
authors.forename: B
authors.initials: B
authors.lastname: Devictor-Pierre
authors.forename: G
authors.initials: G
authors.lastname: Galy
authors.forename: N
authors.initials: N
authors.lastname: André
authors.forename: C
authors.initials: C
authors.lastname: Coze
authors.forename: B
authors.initials: B
authors.lastname: Lacarelle
authors.forename: J-L
authors.initials: JL
authors.lastname: Bernard
authors.forename: S
authors.initials: S
authors.lastname: Monjanel-Mouterde
mesh_terms: D000293:Adolescent; D000931:Antidotes / Q000008:administration & dosage* / Q000627:therapeutic use; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage* / Q000097:blood / Q000506:poisoning*; D001859:Bone Neoplasms / Q000188:drug therapy; D016903:Drug Monitoring / Q000379:methods; D005260:Female; D006801:Humans; D008727:Methotrexate / Q000008:administration & dosage* / Q000097:blood / Q000506:poisoning*; D012516:Osteosarcoma / Q000188:drug therapy; D011623:gamma-Glutamyl Hydrolase / Q000008:administration & dosage* / Q000627:therapeutic use
chemical_list: D000931:Antidotes; D000964:Antimetabolites, Antineoplastic; D011623:gamma-Glutamyl Hydrolase; D008727:Methotrexate