title: Chondromyxoid fibroma of the nasal cavity with an interstitial insertion between chromosomes 6 and 19.
abstract: Chondromyxoid fibroma is an uncommon benign cartilaginous tumor that rarely presents in the sino-nasal region as a locally destructive, erosive lesion. Both clinically and histologically, it is a difficult diagnosis and can be confused with malignant processes such as myxoid chondrosarcoma. Histology of the tumor, especially with a small sample, can be challenging because of its heterogeneous nature showing an admixture of fibrous, myxoid, and chondroid areas. We are reporting unique cytogenetic findings in a case of chondromyxoid fibroma involving the floor of the nasal cavity with a clonal rearrangement between chromosomes 6 and 19. To our knowledge, karyotypes of 14 cases are reported in literature, with 11 cases reporting nonrandom, clonal abnormalities of chromosome 6. These results illustrate the distinctive nature of this tumor and may help identify genes involved in the pathogenesis of this tumor.
authors.affiliation: Department of Pathology, Oregon Health and Sciences University, Portland, OR 97239, USA.
authors.forename: Cristina A
authors.initials: CA
authors.lastname: Smith
authors.forename: R Ellen
authors.initials: RE
authors.lastname: Magenis
authors.forename: Eleanor
authors.initials: E
authors.lastname: Himoe
authors.forename: Cheree
authors.initials: C
authors.lastname: Smith
authors.forename: Atiya
authors.initials: A
authors.lastname: Mansoor
mesh_terms: D002888:Chromosomes, Human, Pair 19; D002896:Chromosomes, Human, Pair 6; D004251:DNA Transposable Elements; D005260:Female; D005350:Fibroma / Q000235:genetics* / Q000473:pathology; D006801:Humans; D008875:Middle Aged; D009296:Nasal Cavity; D009669:Nose Neoplasms / Q000235:genetics* / Q000473:pathology; D014178:Translocation, Genetic
chemical_list: D004251:DNA Transposable Elements