title: [Brain and spinal cord magnetic resonance imaging in spastic paraparesis associated to human T-lymphotropic virus].
abstract: BACKGROUND
  The spastic paraparesis associated to HTLV-1 causes degenerative pyramidal tract lesions of the spinal cord and affects cortical-nuclear connections in the brain.
  
  
  OBJECTIVE
  To report the findings of magnetic resonance imaging in patients with spastic paraparesis.
  
  
  METHODS
  A magnetic resonance imaging of the brain and spinal cord was performed in 30 patients (24 females), mean age and evolution of 56 and 12 years respectively, with a clinical and virological diagnosis of tropical spastic paraparesis/HTLV-1 associated myelopathy (TSP/HAM).
  
  
  RESULTS
  No patient had abnormal signals in the spinal cord parenchyma. However, an atrophy of the dorsal segment was observed in 87% of patients. Patients with the highest degree of atrophy showed a higher degree of functional impairment. Eleven patients had spinal cord conus atrophy, associated to neurogenic bladder or impotency. In 80% of patients, hyperintense subcortical white matter images in DP, T2 and Flair, mostly bi frontal, were detected. In half of them, small rounded and isolated images were observed. In the other half, eight or more images, generally larger and occasionally confluent, were found. Ten of 12 patients with confluent brain lesions showed different degrees of cognitive impairment. No patient had lesions in the corpus callosus, periventricular white matter, pons, medulla oblongata or cerebellum.
  
  
  CONCLUSIONS
  Most patients with tropical spastic paraparesis have alterations in brain or spinal cord magnetic resonance imaging. The magnetic resonance lesions are concordant with functional impairment. The characteristics of the imaging in TSP/HAM patients can be helpful in the differential diagnosis of patients with paraparesis.
authors.affiliation: Neurorradiología Diagnoimagen, Departamento de Ciencias Neurológicas, Facultad de Medicina, Universidad de Chile, Chile.
authors.forename: Jorge
authors.initials: J
authors.lastname: Cervilla
authors.forename: Luis
authors.initials: L
authors.lastname: Cartier
authors.forename: Luis
authors.initials: L
authors.lastname: García
mesh_terms: D000328:Adult; D000368:Aged; D001284:Atrophy; D001921:Brain / Q000473:pathology* / Q000821:virology; D003937:Diagnosis, Differential; D005260:Female; D015490:HTLV-I Infections / Q000473:pathology* / Q000821:virology; D015368:Human T-lymphotropic virus 1; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D015493:Paraparesis, Tropical Spastic / Q000473:pathology* / Q000821:virology; D013116:Spinal Cord / Q000473:pathology* / Q000821:virology