title: Vocal outcomes after laser resection of early-stage glottic cancer with adjuvant cryotherapy.
abstract: OBJECTIVE
  To evaluate the vocal outcomes of patients with early-stage glottic carcinoma undergoing laser resection with adjuvant cryoablative therapy.
  
  
  METHODS
  Retrospective review.
  
  
  METHODS
  Tertiary care center. Patients Twenty patients with early-stage glottic carcinoma. Intervention Treatment of early-stage glottic carcinoma with endoscopic carbon dioxide laser resection in conjunction with cryoablation.
  
  
  METHODS
  Disease-free survival and subjective and objective measures of posttreatment voice quality, based on serial videolaryngostroboscopy.
  
  
  RESULTS
  There was 1 local treatment failure, with an overall mean disease-free follow-up of 32.6 months (range, 3-93 months). Carbon dioxide laser resection and cryoablative therapy were associated with a significant improvement in subjective voice quality (P<.001). Long-term dysphonia was uniformly improved vis-à-vis the pretreatment condition, even among patients with the most advanced disease undergoing the widest resections. Posttreatment web formation was not noted among 4 patients with anterior commissure involvement.
  
  
  CONCLUSIONS
  Endoscopic laser laryngeal surgery performed in conjunction with cryotherapy for early-stage glottic carcinoma yielded excellent primary site control, while improving subjective and objective measures of voice quality. Combined laser surgery and cryotherapy is a possible alternative to radiotherapy for selected patients with early-stage glottic carcinoma who desire curative therapy, while optimizing vocal outcomes.
authors.affiliation: Head and Neck Institute and Voice Center, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA.
authors.forename: P Daniel
authors.initials: PD
authors.lastname: Knott
authors.forename: Claudio F
authors.initials: CF
authors.lastname: Milstein
authors.forename: Douglas M
authors.initials: DM
authors.lastname: Hicks
authors.forename: Tom I
authors.initials: TI
authors.lastname: Abelson
authors.forename: Michael C
authors.initials: MC
authors.lastname: Byrd
authors.forename: Marshall
authors.initials: M
authors.lastname: Strome
mesh_terms: D003452:Cryosurgery; D018572:Disease-Free Survival; D005931:Glottis; D006801:Humans; D007822:Laryngeal Neoplasms / Q000401:mortality / Q000503:physiopathology / Q000601:surgery*; D053685:Laser Therapy; D010699:Phonation / Q000502:physiology; D012189:Retrospective Studies; D014833:Voice Quality