title: Mapping of the WHO-ART terminology on Snomed CT to improve grouping of related adverse drug reactions.
abstract: The WHO-ART and MedDRA terminologies used for coding adverse drug reactions (ADR) do not provide formal definitions of terms. In order to improve groupings, we propose to map ADR terms to equivalent Snomed CT concepts through UMLS Metathesaurus. We performed such mappings on WHO-ART terms and can automatically classify them using a description logic definition expressing their synonymies. Our gold standard was a set of 13 MedDRA special search categories restricted to ADR terms available in WHO-ART. The overlapping of the groupings within the new structure of WHO-ART on the manually built MedDRA search categories showed a 71% success rate. We plan to improve our method in order to retrieve associative relations between WHO-ART terms.
authors.affiliation: INSERM U729, Université Paris Descartes, Faculté de Médecine, Paris, France. Iulian.alecu@SPIM.jussieu.fr
authors.forename: Iulian
authors.initials: I
authors.lastname: Alecu
authors.forename: Cedric
authors.initials: C
authors.lastname: Bousquet
authors.forename: Fleur
authors.initials: F
authors.lastname: Mougin
authors.forename: Marie-Christine
authors.initials: MC
authors.lastname: Jaulent
mesh_terms: D016907:Adverse Drug Reaction Reporting Systems; D039061:Systematized Nomenclature of Medicine; D009626:Terminology as Topic; D017432:Unified Medical Language System; D014944:World Health Organization