title: Synthesis of a versatile constrained analogue of dipeptide DG (Asp-Gly).
abstract: The synthesis of an orthogonally protected constrained analogue of dipeptide DG (Asp-Gly) is reported exploiting alkylation of a chiral lactam. The versatility of this analogue was proven by removal of t-Boc protecting group, followed by coupling under homogeneous conditions with t-Boc-Arg(Z(2))-Gly, to give a conformationally restricted analogue of RGDG tetrapeptide.
authors.affiliation: Dipartimento di Scienze dei Materiali e della Terra, Università Politecnica delle Marche, Ancona, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Galeazzi
authors.forename: E
authors.initials: E
authors.lastname: Marcucci
authors.forename: G
authors.initials: G
authors.lastname: Martelli
authors.forename: D
authors.initials: D
authors.lastname: Natali
authors.forename: M
authors.initials: M
authors.lastname: Orena
authors.forename: S
authors.initials: S
authors.lastname: Rinaldi
mesh_terms: D032701:Biomimetics; D004151:Dipeptides / Q000138:chemical synthesis*
chemical_list: D004151:Dipeptides; C017033:aspartylglycine