title: Pelvic organ prolapse in nulliparous women and their parous sisters.
abstract: OBJECTIVE
  To investigate the role of vaginal delivery and familial factors in the development of pelvic organ prolapse by comparing the prevalence of this condition in nulliparous women and their parous sisters.
  
  
  METHODS
  Pairs of nulliparous and parous postmenopausal sisters were recruited for assessment of pelvic organ prolapse. One hundred one sister pairs underwent clinical evaluation. Pelvic organ prolapse was recorded using the Pelvic Organ Prolapse Quantification System.
  
  
  RESULTS
  The majority of women had no pelvic organ prolapse. By compartment there was a 74.3% to 91.1% concordance in prolapse stage within sister pairs. In discordant sister pairs, the parous sister was found to have the more advanced prolapse 88% of the time.
  
  
  CONCLUSIONS
  High concordance of pelvic organ prolapse in nulliparous and parous sister pairs suggests a familial predisposition toward developing this condition. However, vaginal delivery does appear to confer a risk for more advanced pelvic organ prolapse.
  
  
  METHODS
  II-2.
authors.affiliation: Department of Obstetrics and Gynecology, University of Rochester Medical Center, Rochester, New York 14642, USA. Gunhilde_Buchsbaum@urmc.rochester.edu
authors.forename: Gunhilde M
authors.initials: GM
authors.lastname: Buchsbaum
authors.forename: Erin E
authors.initials: EE
authors.lastname: Duecy
authors.forename: Lindsey A
authors.initials: LA
authors.lastname: Kerr
authors.forename: Li-Shan
authors.initials: LS
authors.lastname: Huang
authors.forename: MaryAnn
authors.initials: M
authors.lastname: Perevich
authors.forename: David S
authors.initials: DS
authors.lastname: Guzick
mesh_terms: D036861:Delivery, Obstetric; D005260:Female; D006801:Humans; D008875:Middle Aged; D010298:Parity; D017698:Postmenopause; D011247:Pregnancy; D014596:Uterine Prolapse / Q000209:etiology / Q000235:genetics*