title: Human milk glycoproteins inhibit the adherence of Salmonella typhimurium to HeLa cells.
abstract: The ability of human milk, as well as its protein fractions, to inhibit the adhesion and invasion of Salmonella typhimurium to HeLa cells was investigated. The results revealed that milk secretory immunoglobulin A (sIgA) inhibited neither the adherence nor the bacterial invasion; however, free secretory component and lactoferrin inhibited the bacterial adhesion and interacted with several bacterial proteins. Our data indicated that glycoproteins such as free secretory component and lactoferrin could act as protective compounds against infant enteric diseases, possibly binding to bacterial surface and blocking adhesion, the primordial step of S. typhimurium infection.
authors.affiliation: Laboratório de Microbiologia, Departamento de Biologia Celular, Instituto de Ciências Biológicas, Universidade de Brasília, Brazil.
authors.forename: Heidi Christina
authors.initials: HC
authors.lastname: Bessler
authors.forename: Inaiara Rosa
authors.initials: IR
authors.lastname: de Oliveira
authors.forename: Loreny Gimenes
authors.initials: LG
authors.lastname: Giugliano
mesh_terms: D001422:Bacterial Adhesion; D006023:Glycoproteins / Q000502:physiology*; D006367:HeLa Cells; D006801:Humans; D007781:Lactoferrin / Q000502:physiology*; D008895:Milk, Human / Q000737:chemistry*; D012486:Salmonella typhimurium / Q000472:pathogenicity / Q000502:physiology*; D012635:Secretory Component / Q000502:physiology*
chemical_list: D006023:Glycoproteins; D012635:Secretory Component; D007781:Lactoferrin