Application of advanced technologies in ageing research.
Several technologies that emerged in the post-genomic era have been particularly useful in dissecting the molecular mechanisms of complex biological processes through the systems approach. Here, we review how three of these technologies, namely transcriptional profiling, large-scale RNA interference (RNAi) and genome-wide location analysis of protein-DNA interactions, have been used in the study of ageing in metazoans. We also highlight recent developments of these three technologies and how these developments are applicable to ageing research.
Lim
Ching-Aeng
CA
Gene Regulation Laboratory, Genome Institute of Singapore, Singapore 138672. limca@gis.a-star.edu.sg
Ng
Huck-Hui
HH
D000375:Aging / Q000235:genetics / Q000502:physiology*; D000818:Animals; D004247:DNA / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000378:metabolism*; D020869:Gene Expression Profiling; D006801:Humans; D011485:Protein Binding / Q000502:physiology; D034622:RNA Interference
D004268:DNA-Binding Proteins; D004247:DNA