title: FireDB--a database of functionally important residues from proteins of known structure.
abstract: The FireDB database is a databank for functional information relating to proteins with known structures. It contains the most comprehensive and detailed repository of known functionally important residues, bringing together both ligand binding and catalytic residues in one site. The platform integrates biologically relevant data filtered from the close atomic contacts in Protein Data Bank crystal structures and reliably annotated catalytic residues from the Catalytic Site Atlas. The interface allows users to make queries by protein, ligand or keyword. Relevant biologically important residues are displayed in a simple and easy to read manner that allows users to assess binding site similarity across homologous proteins. Binding site residue variations can also be viewed with molecular visualization tools. The database is available at http://firedb.bioinfo.cnio.es.
authors.affiliation: Computational and Structural Biology Program, Spanish National Cancer Research Centre (CNIO) Melchor Fernández Almagro, 3, E-28029, Madrid, Spain. glopez@cnio.es
authors.forename: Gonzalo
authors.initials: G
authors.lastname: Lopez
authors.forename: A
authors.initials: A
authors.lastname: Valencia
authors.forename: M
authors.initials: M
authors.lastname: Tress
mesh_terms: D000596:Amino Acids / Q000737:chemistry*; D001665:Binding Sites; D020134:Catalytic Domain; D030562:Databases, Protein; D020407:Internet; D008024:Ligands; D008958:Models, Molecular; D011487:Protein Conformation; D011506:Proteins / Q000737:chemistry*; D022021:Tacrolimus Binding Proteins / Q000737:chemistry; D014584:User-Computer Interface
chemical_list: D000596:Amino Acids; D008024:Ligands; D011506:Proteins; D022021:Tacrolimus Binding Proteins