title: Familial occurrence of inflammatory bowel disease in Korea.
abstract: BACKGROUND
  Little information is available about the familial aggregation of inflammatory bowel disease (IBD) in Asian populations. We therefore determined the risk of familial aggregation of IBD among first-degree relatives of patients with ulcerative colitis (UC) or Crohn's disease (CD) in an ethnically distinct Korean population.
  
  
  METHODS
  Familial aggregation of IBD was evaluated in terms of family history, prevalence, lifetime risk, and population relative risk in first-degree relatives of 1440 unrelated patients with UC (n = 1043) or CD (n = 397).
  
  
  RESULTS
  A positive first-degree family history of IBD was observed in 27 probands (1.88%): 21 of 1043 (2.01%) with UC and 6 of 397 (1.51%) with CD. The crude prevalence of IBD in first-degree relatives of probands with IBD was 0.31%. The lifetime risk of IBD was 0.54% in all first-degree relatives of IBD probands, 0.52% in UC probands, and 0.67% in CD probands, with overall lifetime relative risks of 0.12% in parents, 0.79% in siblings, and 1.43% in offspring. The age- and sex-adjusted population relative risk of IBD was 13.8 in first-degree relatives of probands with IBD.
  
  
  CONCLUSIONS
  Although a positive family history, prevalence, and lifetime risk of IBD among first-degree relatives of Korean IBD patients are much lower than among relatives of Western patients, the population relative risk in first-degree relatives is about equal in Koreans and Westerners. This finding indicates that a positive family history is an important risk factor for IBD in Koreans and in Westerners.
authors.affiliation: Departments of Internal Medicine and Surgery, Song Do Colorectal Hospital, University of Ulsan College of Medicine, Asan Medical Center, Seoul 138-736, Korea.
authors.forename: Jong Beom
authors.initials: JB
authors.lastname: Park
authors.forename: Suk-Kyun
authors.initials: SK
authors.lastname: Yang
authors.forename: Jeong-Sik
authors.initials: JS
authors.lastname: Byeon
authors.forename: Eui-Ryun
authors.initials: ER
authors.lastname: Park
authors.forename: Gyoo
authors.initials: G
authors.lastname: Moon
authors.forename: Seung Jae
authors.initials: SJ
authors.lastname: Myung
authors.forename: Won Kap
authors.initials: WK
authors.lastname: Park
authors.forename: Seo Gue
authors.initials: SG
authors.lastname: Yoon
authors.forename: Hyun Shig
authors.initials: HS
authors.lastname: Kim
authors.forename: Jong Gyun
authors.initials: JG
authors.lastname: Lee
authors.forename: Jin Ho
authors.initials: JH
authors.lastname: Kim
authors.forename: Young
authors.initials: Y
authors.lastname: Il Min
authors.forename: Kwang Yeon
authors.initials: KY
authors.lastname: Kim
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D003710:Demography; D005192:Family Health; D005260:Female; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000453:epidemiology*; D007723:Korea / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D018570:Risk Assessment