Absence of angiogenic genes modification in Italian ALS patients.
To investigate the role of vascular endothelial growth factor (VEGF) and angiogenin (ANG) as genetic determinants in the susceptibility to sporadic ALS in Italian patients. VEGF genotype and haplotype analysis revealed no association between any variants and the risk of ALS. Regarding ANG gene, no mutation was detected and the rs11701 polymorphism, previously described as associated with ALS, was not differently distributed between patients and controls. Overall, our data argue against the hypothesis of both genes as risk factors for motoneuron neurodegeneration, at least in an Italian population.
Del Bo
Roberto
R
Dino Ferrari Centre, Department of Neurological Sciences, University of Milan, IRCCS Foundation Ospedale Maggiore Policlinico Mangiagalli and Regina Elena, Milan, Italy. roberto.delbo@unimi.it
Scarlato
Marina
M
Ghezzi
Serena
S
Martinelli-Boneschi
Filippo
F
Corti
Stefania
S
Locatelli
Federica
F
Santoro
Domenico
D
Prelle
Alessandro
A
Briani
Chiara
C
Nardini
Martina
M
Siciliano
Gabriele
G
Mancuso
Michelangelo
M
Murri
Luigi
L
Bresolin
Nereo
N
Comi
Giacomo Pietro
GP
D000690:Amyotrophic Lateral Sclerosis / Q000453:epidemiology / Q000235:genetics*; D006801:Humans; D007558:Italy / Q000453:epidemiology; D009154:Mutation / Q000235:genetics*; D011110:Polymorphism, Genetic; D012259:Ribonuclease, Pancreatic / Q000172:deficiency* / Q000235:genetics*; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics
D042461:Vascular Endothelial Growth Factor A; C046366:angiogenin; D012259:Ribonuclease, Pancreatic