title: Temporal cross-talk between TCR and STAT signals for CD8 T cell effector differentiation.
abstract: The strength and duration of signaling through surface receptors is a primary means of controlling cell fate decisions. In adaptive immunity, Ag-initiated T cell stimulation is secondarily regulated by cytokines. We here summarize evidence for temporal control of a gene expression program in naive CD8 T cells. It is initiated in response to TCR engagement but relies on secondary signaling from cytokine receptors to be sustained and to allow development of full effector capacity. This mechanism permits cytokine receptor signaling to rescue abortive TCR signaling, such as that induced in response to weak or partial TCR agonists. Indeed, limiting TCR-initiated signaling on the Ras/ERK pathway may be complemented by STAT activation. Thus, TCR- and cytokine-driven activation of transcription factors and epigenetic modifications may act in concert in a temporally staggered process to establish the functional program of effector CD8 T cells. Based on gene expression profiling, molecular targets whose activation or inactivation may boost or dampen CD8 T cell effectors are also identified. Manipulation of these targets may, respectively, increase anti-tumor responses or prevent graft-versus-host reactions.
authors.affiliation: Centre d'Immunologie de Marseille-Luminy, INSERM U631, CNRS UMR 6102, Université de la Méditerranée, Marseille, France.
authors.forename: Grégory
authors.initials: G
authors.lastname: Verdeil
authors.forename: Julie
authors.initials: J
authors.lastname: Chaix
authors.forename: Anne-Marie
authors.initials: AM
authors.lastname: Schmitt-Verhulst
authors.forename: Nathalie
authors.initials: N
authors.lastname: Auphan-Anezin
mesh_terms: D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000166:cytology* / Q000378:metabolism*; D002454:Cell Differentiation / Q000276:immunology*; D006801:Humans; D020239:Receptor Cross-Talk / Q000502:physiology*; D011948:Receptors, Antigen, T-Cell / Q000502:physiology*; D050791:STAT Transcription Factors / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*; D013997:Time Factors
chemical_list: D011948:Receptors, Antigen, T-Cell; D050791:STAT Transcription Factors