Chemoprevention of Scutellaria bardata on human cancer cells and tumorigenesis in skin cancer.
Scutellaria barbata D. Don (Lamiaceae) (SB) is a perennial herb, which is natively distributed throughout Korea and southern China. This herb is known in traditional Chinese medicine as Ban-Zhi-Lian and in traditional Korean medicine as Banjiryun. SB has been used as an antiinflammatory and antitumor agent. The SB showed strong growth-inhibitory activity and cancer chemopreventive activity in assays representing three major stages of carcinogenesis. The SB was found to act as an antimutagen; it mediated antiinflammatory effects; inhibited cyclooxygenase and hydroperoxidase functions (antipromotion activity). In addition, SB inhibited the development of preneoplastic lesions in carcinogen-treated mouse mammary glands in culture and inhibited tumorigenesis in a mouse skin cancer model. On the other hand, an inhibitory effect of SB on the growth of gynecological cancer cell lines such as HeLa cell and human ovary cancer (HOC) was shown. When HOC cells were treated with SB, the expression of cyclooxygenase-2 was inhibited. These data suggest that SB merits investigation as a potential cancer chemopreventive agent in humans, especially in gynecological cancers.
Suh
Seok-Jong
SJ
Department of Biological Sciences, Sungkyunkwan University, Chunchun-Dong 300, Suwon City, Kyunggi-Do 440-746, Korea.
Yoon
Jong-Won
JW
Lee
Tae-Kyun
TK
Jin
Un-Ho
UH
Kim
Sun-Lim
SL
Kim
Myung-Sunny
MS
Kwon
Dae Young
DY
Lee
Young-Choon
YC
Kim
Cheorl-Ho
CH
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D016588:Anticarcinogenic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D016587:Antimutagenic Agents / Q000494:pharmacology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D051546:Cyclooxygenase 2 / Q000378:metabolism; D052246:Cyclooxygenase 2 Inhibitors / Q000494:pharmacology; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D006367:HeLa Cells; D006801:Humans; D015674:Mammary Neoplasms, Animal / Q000517:prevention & control; D051379:Mice; D051381:Rats; D031363:Scutellaria / Q000737:chemistry*; D012878:Skin Neoplasms / Q000517:prevention & control*; D014594:Uterine Neoplasms / Q000188:drug therapy*
D000893:Anti-Inflammatory Agents; D016588:Anticarcinogenic Agents; D016587:Antimutagenic Agents; D052246:Cyclooxygenase 2 Inhibitors; D004365:Drugs, Chinese Herbal; C519373:ban-zhi-lian; D051546:Cyclooxygenase 2