The usefulness of simple X-ray powder diffraction analysis for counterfeit control--the Viagra example.
Counterfeit and illegally manufactured drugs become a very important problem all over the world, hence, a search for new fast, easy, reliable and not expensive methods of drugs screening is essential. We describe the use of X-ray powder diffraction method for the fast screening of tablets for counterfeit medicines identification. The original Viagra tablets and some counterfeit and/or imitations of Viagra were used as example. We demonstrate the application of diffraction method for discrimination of tablets coatings and for identification of differences in drug composition. The X-ray diffraction method turns out to be very fast and reliable for detecting counterfeits and imitation, and it correctly predicts the presence or absence of active substance and/or particular excipients.
Maurin
Jan K
JK
The National Drug Institute, Chełmska 30/34, 00-725 Warsaw, Poland. maurin@il.waw.pl
Pluciński
Franciszek
F
Mazurek
Aleksander P
AP
Fijałek
Zbigniew
Z
D005079:Excipients / Q000032:analysis; D005607:Fraud / Q000517:prevention & control*; D004364:Pharmaceutical Preparations / Q000592:standards*; D010726:Phosphodiesterase Inhibitors / Q000032:analysis*; D010879:Piperazines / Q000032:analysis*; D011208:Powders / Q000032:analysis; D011687:Purines / Q000032:analysis; D015203:Reproducibility of Results; D000068677:Sildenafil Citrate; D013450:Sulfones / Q000032:analysis*; D013608:Tablets, Enteric-Coated; D013997:Time Factors; D014961:X-Ray Diffraction / Q000379:methods*
D005079:Excipients; D004364:Pharmaceutical Preparations; D010726:Phosphodiesterase Inhibitors; D010879:Piperazines; D011208:Powders; D011687:Purines; D013450:Sulfones; D013608:Tablets, Enteric-Coated; D000068677:Sildenafil Citrate