title: Perioperative amino acid infusion improves recovery and shortens the duration of hospitalization after off-pump coronary artery bypass grafting.
abstract: Perioperative amino acid infusion helps maintain core temperature and improves patient outcomes after gynecologic and orthopedic surgery. In the present study we prospectively determined the effect of amino acid infusion on esophageal core temperature and postoperative outcomes during off-pump coronary artery bypass grafting (CABG). One-hundred-eighty consecutive patients undergoing primary elective or urgent off-pump CABG were randomly divided into two groups: the i.v. amino acid infusion group (4 kJ kg(-1) h(-1) starting 2 h before surgery) and the saline infusion group (similar period and volume of saline infusion). The esophageal core temperature at the end of surgery was 35.6 (35.3-35.8) degrees C [mean (95% confidence interval)] in the saline infusion group and 36.1 degrees C (35.9-36.3) degrees C in the amino acid infusion group (P = 0.01). Kaplan-Meier analysis demonstrated that patients given amino acids required a significantly shorter duration of postoperative mechanical ventilation than patients given saline [median (95% confidence interval), 3.0 (2.5-3.9) vs 4.5 (3.8-5.8) h; P = 0.01]. Furthermore, intensive care unit stay [20 (19.5-38.4) vs 44 (21-45) h; P = 0.001] and days until fit for discharge from hospital [10 (9-11) vs 12 (11-13) days; P = 0.004] were significantly shorter in patients given amino acid. Perioperative amino acid infusion in patients undergoing off-pump CABG effectively minimizes intraoperative hypothermia and improves postoperative recovery.
authors.forename: Takako
authors.initials: T
authors.lastname: Umenai
authors.forename: Yasufumi
authors.initials: Y
authors.lastname: Nakajima
authors.forename: Daniel I
authors.initials: DI
authors.lastname: Sessler
authors.forename: Satoshi
authors.initials: S
authors.lastname: Taniguchi
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Yaku
authors.forename: Toshiki
authors.initials: T
authors.lastname: Mizobe
mesh_terms: D000368:Aged; D000596:Amino Acids / Q000008:administration & dosage*; D001281:Atrial Fibrillation / Q000517:prevention & control; D001831:Body Temperature; D047549:Coronary Artery Bypass, Off-Pump; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007902:Length of Stay; D008297:Male; D019990:Perioperative Care; D011446:Prospective Studies
chemical_list: D000596:Amino Acids