title: Diabetes of injury: novel insights.
abstract: Critically ill patients usually develop hyperglycemia, a condition referred to as "diabetes of injury." More and more evidence argues against the concept that this is an adaptive beneficial response. Indeed, the development of hyperglycemia seems to be detrimental for the outcome of critically ill patients, because maintenance of normoglycemia with intensive insulin therapy prevents morbidity and reduces mortality of critically ill patients to a large extent. The mechanisms underlying these clinical benefits are being studied further.
authors.affiliation: Department of Intensive Care Medicine, Katholieke Universiteit Leuven, Herestraat 49, B-300 Leuven, Belgium.
authors.forename: Ilse
authors.initials: I
authors.lastname: Vanhorebeek
authors.forename: Greet
authors.initials: G
authors.lastname: Van den Berghe
mesh_terms: D003422:Critical Care / Q000379:methods; D016638:Critical Illness / Q000628:therapy; D006801:Humans; D006943:Hyperglycemia / Q000188:drug therapy* / Q000209:etiology*; D007328:Insulin / Q000008:administration & dosage* / Q000009:adverse effects
chemical_list: D007328:Insulin