title: [Polycystic ovary syndrome: an example of obesity-related cardiovascular complication affecting young women].
abstract: Polycystic ovary syndrome (PCOS) is a good example of obesity-related cardiovascular complication affecting young women. PCOS is not only considered a reproductive problem but rather represents a complex endocrine, multifaceted syndrome with important health implications. Several evidences suggest an increased cardiovascular risk of cardiovascular disease associated with this syndrome, characterized by an impairment of heart structure and function, endothelial dysfunction and lipid abnormalities. All these features, probably linked to insulin-resistance, are often present in obese PCOS patients. Cardiovascular abnormalities represent important long-term sequelae of PCOS that need further investigations.
authors.affiliation: Department of Molecular & Clinical Endocrinology and Oncology, University Federico II of Naples, Via S. Pansini 5, 80131 Naples, Italy. francescoorio@virgilio.it
authors.forename: Francesco
authors.initials: F
authors.lastname: Orio
authors.forename: Teresa
authors.initials: T
authors.lastname: Cascella
authors.forename: Francesco
authors.initials: F
authors.lastname: Giallauria
authors.forename: Stefano
authors.initials: S
authors.lastname: Palomba
authors.forename: Anna
authors.initials: A
authors.lastname: De Lorenzo
authors.forename: Rosa
authors.initials: R
authors.lastname: Lucci
authors.forename: Elena
authors.initials: E
authors.lastname: Ambrosino
authors.forename: Gaetano
authors.initials: G
authors.lastname: Lombardi
authors.forename: Annamaria
authors.initials: A
authors.lastname: Colao
authors.forename: Carlo
authors.initials: C
authors.lastname: Vigorito
mesh_terms: D015415:Biomarkers / Q000097:blood; D002318:Cardiovascular Diseases / Q000097:blood / Q000209:etiology* / Q000503:physiopathology; D019332:Endothelin-1 / Q000097:blood; D005260:Female; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000209:etiology; D007333:Insulin Resistance; D009765:Obesity / Q000097:blood / Q000150:complications* / Q000503:physiopathology; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000150:complications* / Q000503:physiopathology; D018570:Risk Assessment; D012307:Risk Factors
chemical_list: D015415:Biomarkers; D019332:Endothelin-1; D017395:Plasminogen Activator Inhibitor 1