Effects of hyperbaric exposure with high oxygen concentration on the physical activity of developing rats.
The effects of hyperbaric exposure with high oxygen concentration on the physical activity of developing male rats were investigated. Five-week-old male rats were exposed to an atmospheric pressure of 1.25 with an oxygen concentration of 36.0% for 12 h (7.00-19.00 h) and exercised voluntarily for 12 h (19.00-7.00 h) daily for 8 weeks. The voluntary running activities were compared with those in age-matched rats without hyperbaric exposure. In addition, the properties of the soleus and plantaris muscle fibers and their spinal motoneurons were examined. The voluntary running activities of rats with or without hyperbaric exposure increased during development. However, the mean voluntary running activities were higher in rats with hyperbaric exposure (7,104 m/day) than in those without hyperbaric exposure (4,932 m/day). The oxidative capacities of the soleus and plantaris muscle fibers and their spinal motoneurons increased following hyperbaric exposure. It is suggested that adaptations of neuromuscular units to hyperbaric exposure with high oxygen concentration enhance the metabolism, and thus, the function of neuromuscular units is promoted.
Matsumoto
A
A
Laboratory of Neurochemistry, Graduate School of Human and Environmental Studies, Kyoto University, Kyoto, Japan.
Okiura
T
T
Morimatsu
F
F
Ohira
Y
Y
Ishihara
A
A
D000818:Animals; D000831:Animals, Newborn / Q000254:growth & development / Q000502:physiology*; D001274:Atmospheric Pressure; D001835:Body Weight / Q000187:drug effects; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D009046:Motor Neurons / Q000201:enzymology; D018485:Muscle Fibers, Skeletal / Q000378:metabolism / Q000648:ultrastructure; D018482:Muscle, Skeletal / Q000033:anatomy & histology / Q000294:innervation / Q000378:metabolism / Q000648:ultrastructure; D009929:Organ Size / Q000187:drug effects; D009994:Osmolar Concentration; D010084:Oxidation-Reduction; D010100:Oxygen / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013116:Spinal Cord / Q000166:cytology / Q000201:enzymology; D014836:Volition
D010100:Oxygen