title: Synthesis of pyochelin-norfloxacin conjugates.
abstract: Using synthetic functionalized analogues of pyochelin, a siderophore common to several pathogenic Pseudomonas and Burkholderia species, four fluoroquinolone-pyochelin conjugates were efficiently synthesized and evaluated for their biological activities.
authors.affiliation: Métaux et Microorganismes: Chimie, Biologie et Applications, UMR 7175-LC1 Institut Gilbert Laustriat CNRS-Université Louis Pasteur (Strasbourg I), ESBS, Boulevard Sébastien Brant, F-67400 Illkirch, France.
authors.forename: Freddy
authors.initials: F
authors.lastname: Rivault
authors.forename: Clémence
authors.initials: C
authors.lastname: Liébert
authors.forename: Alain
authors.initials: A
authors.lastname: Burger
authors.forename: Françoise
authors.initials: F
authors.lastname: Hoegy
authors.forename: Mohamed A
authors.initials: MA
authors.lastname: Abdallah
authors.forename: Isabelle J
authors.initials: IJ
authors.lastname: Schalk
authors.forename: Gaëtan L A
authors.initials: GL
authors.lastname: Mislin
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D016956:Burkholderia cepacia / Q000187:drug effects; D007502:Iron Chelating Agents / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D009643:Norfloxacin / Q000737:chemistry* / Q000494:pharmacology*; D010636:Phenols / Q000737:chemistry* / Q000494:pharmacology*; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013329:Structure-Activity Relationship; D013844:Thiazoles / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D007502:Iron Chelating Agents; D010636:Phenols; D013844:Thiazoles; C025316:pyochelin; D009643:Norfloxacin