title: In vivo study of propolis supplementation effects on antioxidative status and red blood cells.
abstract: In vivo study has been conducted on 47 healthy women and men in order to investigate whether daily intake of powdered propolis extract during 30 days has any influence on the following blood parameters: activity of superoxide dismutase, glutathione peroxidase and catalase, concentration of plasma malondialdehyde, total cholesterol, low- and high-density lipoprotein cholesterol, triglycerides, glucose, uric acid, ferritin and transferrin, together with routine red blood cell parameters. The effect of daily propolis intake seems to be time and gender related. For the men test group after the initial 15 days of propolis treatment, 23.2% (p=0.005) decrease in concentration of malondialdehyde was observed. After 30 days of treatment, statistically significant (p=0.010) 20.9% increase in superoxide dismutase activity and change in some of the red blood cell parameters were detected. For the women test group, the propolis treatment did not induce a change in any of the measured parameters.
authors.affiliation: Department of Medicinal Chemistry, University of Zagreb, A. Kovacića 1, 10 000 Zagreb, Croatia.
authors.forename: Ivona
authors.initials: I
authors.lastname: Jasprica
authors.forename: Ana
authors.initials: A
authors.lastname: Mornar
authors.forename: Zeljko
authors.initials: Z
authors.lastname: Debeljak
authors.forename: Asja
authors.initials: A
authors.lastname: Smolcić-Bubalo
authors.forename: Marica
authors.initials: M
authors.lastname: Medić-Sarić
authors.forename: Ljiljana
authors.initials: L
authors.lastname: Mayer
authors.forename: Zeljko
authors.initials: Z
authors.lastname: Romić
authors.forename: Kajo
authors.initials: K
authors.lastname: Bućan
authors.forename: Tihomir
authors.initials: T
authors.lastname: Balog
authors.forename: Sandra
authors.initials: S
authors.lastname: Sobocanec
authors.forename: Visnja
authors.initials: V
authors.lastname: Sverko
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000494:pharmacology*; D001786:Blood Glucose / Q000187:drug effects; D002374:Catalase / Q000187:drug effects / Q000378:metabolism; D002784:Cholesterol / Q000097:blood; D004912:Erythrocytes / Q000187:drug effects* / Q000502:physiology; D005260:Female; D005293:Ferritins / Q000097:blood / Q000187:drug effects; D005419:Flavonoids / Q000008:administration & dosage / Q000494:pharmacology*; D005979:Glutathione Peroxidase / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D011429:Propolis / Q000008:administration & dosage / Q000494:pharmacology*; D012737:Sex Factors; D013482:Superoxide Dismutase / Q000187:drug effects / Q000378:metabolism; D014168:Transferrin / Q000187:drug effects / Q000502:physiology; D014280:Triglycerides / Q000097:blood; D014527:Uric Acid / Q000097:blood
chemical_list: D000975:Antioxidants; D001786:Blood Glucose; D005419:Flavonoids; D014168:Transferrin; D014280:Triglycerides; D014527:Uric Acid; D008315:Malondialdehyde; D005293:Ferritins; D011429:Propolis; D002784:Cholesterol; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase