title: Autonomic dysfunction due to lead poisoning.
abstract: We present a case history of a 24 years old male who developed autonomic dysfunction, intestinal pseudo-obstruction and anemia due to lead poisoning. Concomitant recording of blood levels of lead and autonomic function showed a gradual decline in blood lead level (98.8 microg/dL at week 0, 56 microg/dL at week 6, and 40 microg/dL at week 52) and gradual improvement in autonomic functions. Decrease in blood lead levels with DMSA (Meso-2, 3-dimercaptosuccinic acid) therapy showed improvement in autonomic functions. At week 0, the patient had severe loss of autonomic tone and autonomic reactivity which improved at week 6. At the 52nd week, most of the autonomic parameters had normalized except for the persistence of mild loss of parasympathetic reactivity.
authors.affiliation: Department of Physiology, All India Institute of Medical Sciences, Ansari Nagar-110029, New Delhi, India.
authors.forename: Kushal
authors.initials: K
authors.lastname: Madan
authors.forename: Praveen Kumar
authors.initials: PK
authors.lastname: Sharma
authors.forename: Govind
authors.initials: G
authors.lastname: Makharia
authors.forename: Gopal
authors.initials: G
authors.lastname: Poojary
authors.forename: Kishore Kumar
authors.initials: KK
authors.lastname: Deepak
mesh_terms: D000328:Adult; D000740:Anemia / Q000209:etiology*; D001342:Autonomic Nervous System Diseases / Q000188:drug therapy / Q000209:etiology*; D002614:Chelating Agents / Q000627:therapeutic use; D007172:Erectile Dysfunction / Q000188:drug therapy; D006801:Humans; D007418:Intestinal Pseudo-Obstruction / Q000209:etiology*; D007854:Lead / Q000097:blood; D020265:Lead Poisoning, Nervous System, Adult / Q000150:complications* / Q000188:drug therapy / Q000503:physiopathology*; D008297:Male; D008515:Medicine, Ayurvedic; D010946:Plants, Medicinal / Q000009:adverse effects; D004113:Succimer / Q000627:therapeutic use
chemical_list: D002614:Chelating Agents; D007854:Lead; D004113:Succimer