Biosynthetic study of FR-900848: origin of the aminodeoxynucleoside part.
Biosynthetic studies of the antifungal agent, FR-900848, were undertaken by feeding experiments with D-[U-13C,]glucose, L-[4-13C]aspartate, [5,5-2H,]dihydrouridine and [5,5-2H2]dihydrouracil. The 5"-amino-5"-deoxy-5',6'-dihydrouridine moiety was derived from ribose and aspartate. Based on the feeding experiments, a detailed biosynthetic pathway producing the aminodeoxydihydrouridine moiety of FR-900848 was proposed.
Watanabe
Hiroaki
H
Division of Chemistry, Graduate School of Science, Hokkaido University, Sapporo 060-0810, Japan. hoik@sci.hokudai.ac.jp
Tokiwano
Tetsuo
T
Oikawa
Hideaki
H
D000935:Antifungal Agents / Q000378:metabolism*; D001224:Aspartic Acid / Q000378:metabolism; D002247:Carbon Isotopes / Q000378:metabolism; D003521:Cyclopropanes; D003903:Deuterium / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009705:Nucleosides / Q000096:biosynthesis; D012266:Ribose / Q000378:metabolism; D013306:Streptomycetaceae / Q000378:metabolism*
D000935:Antifungal Agents; D002247:Carbon Isotopes; D003521:Cyclopropanes; D009705:Nucleosides; C065437:FR 900848; D001224:Aspartic Acid; D012266:Ribose; D003903:Deuterium