title: [Streptococcus agalactiae highly resistant to fluoroquinolones].
abstract: BACKGROUND
  Streptococcus agalactiae remains susceptible to penicillin; nevertheless, an increase in the resistance to other antimicrobial families, such as macrolides and more rarely fluoroquinolones, has been described.
  
  
  RESULTS
  From 2003 to 2004, two fluoroquinolone-resistant S. agalactiae strains were detected. The strains presented one mutation in parC (Ser79 --> Phe) and an additional mutation in gyrA (Glu85 --> Ala or Glu85 --> Lys).
  
  
  CONCLUSIONS
  This study describes the first S. agalactiae strains highly resistant to fluoroquinolones in Spain.
authors.affiliation: Servicio de Microbiología, Hospital de la Santa Creu i Sant Pau, Barcelona, España.
authors.forename: Elisenda
authors.initials: E
authors.lastname: Miró
authors.forename: Montserrat
authors.initials: M
authors.lastname: Rebollo
authors.forename: Alba
authors.initials: A
authors.lastname: Rivera
authors.forename: M Teresa
authors.initials: MT
authors.lastname: Alvarez
authors.forename: Ferrán
authors.initials: F
authors.lastname: Navarro
authors.forename: Beatriz
authors.initials: B
authors.lastname: Mirelis
authors.forename: Pere
authors.initials: P
authors.lastname: Coll
mesh_terms: D019943:Amino Acid Substitution; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000235:genetics; D001826:Body Fluids / Q000382:microbiology; D027081:DNA Gyrase / Q000235:genetics; D027101:DNA Topoisomerase IV / Q000235:genetics; D004269:DNA, Bacterial / Q000235:genetics / Q000302:isolation & purification; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics; D024841:Fluoroquinolones / Q000494:pharmacology*; D006801:Humans; D008826:Microbial Sensitivity Tests; D020125:Mutation, Missense; D017354:Point Mutation; D013030:Spain / Q000453:epidemiology; D013290:Streptococcal Infections / Q000453:epidemiology / Q000382:microbiology*; D013292:Streptococcus agalactiae / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D004269:DNA, Bacterial; D024841:Fluoroquinolones; D027101:DNA Topoisomerase IV; D027081:DNA Gyrase