title: General nature of the STAT3-activated anti-inflammatory response.
abstract: Although many cytokine receptors generate their signals via the STAT3 pathway, the IL-10R appears unique in promoting a potent anti-inflammatory response (AIR) via STAT3 to antagonize proinflammatory signals that activate the innate immune response. We found that heterologous cytokine receptor systems that activate STAT3 but are naturally refractory (the IL-22R), or engineered to be refractory (the IL-6, leptin, and erythropoietin receptors), to suppressor of cytokine signaling-3-mediated inhibition activate an AIR indistinguishable from IL-10. We conclude that the AIR is a generic cytokine signaling pathway dependent on STAT3 but not unique to the IL-10R.
authors.affiliation: Department of Infectious Diseases, St. Jude's Children's Research Hospital, Memphis, TN 38105, USA.
authors.forename: Karim C
authors.initials: KC
authors.lastname: El Kasmi
authors.forename: Jeff
authors.initials: J
authors.lastname: Holst
authors.forename: Maryaline
authors.initials: M
authors.lastname: Coffre
authors.forename: Lisa
authors.initials: L
authors.lastname: Mielke
authors.forename: Antoine
authors.initials: A
authors.lastname: de Pauw
authors.forename: Nouara
authors.initials: N
authors.lastname: Lhocine
authors.forename: Amber M
authors.initials: AM
authors.lastname: Smith
authors.forename: Robert
authors.initials: R
authors.lastname: Rutschman
authors.forename: Deepak
authors.initials: D
authors.lastname: Kaushal
authors.forename: Yuhong
authors.initials: Y
authors.lastname: Shen
authors.forename: Takashi
authors.initials: T
authors.lastname: Suda
authors.forename: Raymond P
authors.initials: RP
authors.lastname: Donnelly
authors.forename: Martin G
authors.initials: MG
authors.lastname: Myers
authors.forename: Warren
authors.initials: W
authors.lastname: Alexander
authors.forename: Dario A A
authors.initials: DA
authors.lastname: Vignali
authors.forename: Stephanie S
authors.initials: SS
authors.lastname: Watowich
authors.forename: Matthias
authors.initials: M
authors.lastname: Ernst
authors.forename: Douglas J
authors.initials: DJ
authors.lastname: Hilton
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Murray
mesh_terms: D000818:Animals; D004797:Enzyme-Linked Immunosorbent Assay; D015870:Gene Expression; D015151:Immunoblotting; D007249:Inflammation; D016753:Interleukin-10 / Q000378:metabolism*; D015850:Interleukin-6 / Q000378:metabolism*; D051379:Mice; D020411:Oligonucleotide Array Sequence Analysis; D053701:Receptors, Interleukin-10 / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction; D050796:STAT3 Transcription Factor / Q000378:metabolism*; D015398:Signal Transduction / Q000276:immunology*; D000071223:Suppressor of Cytokine Signaling 3 Protein; D050826:Suppressor of Cytokine Signaling Proteins / Q000378:metabolism
chemical_list: D015850:Interleukin-6; D053701:Receptors, Interleukin-10; D050796:STAT3 Transcription Factor; C491411:Socs3 protein, mouse; C494087:Stat3 protein, mouse; D000071223:Suppressor of Cytokine Signaling 3 Protein; D050826:Suppressor of Cytokine Signaling Proteins; D016753:Interleukin-10