title: [Synthesis and bioactivity of 2-arylimino-4-thiazolidones].
abstract: OBJECTIVE
  To synthesize a series of 2-arylimino-4-thiazolidone derivatives and 2-imidazolino [2,3-b]-4-thiazolidone in order to get some novel potent compounds with nitric oxide synthases (NOS) inhibitory activity.
  
  
  METHODS
  The target compounds were prepared by reaction of N-chloroacetyl-1,2,3,4-tetrahydroisoquinoline or N-chloroacetylphthalimide with substituted thioureas, their NOS inhibitory activity were measured.
  
  
  CONCLUSIONS
  The 15 new compounds were synthesized and most of the reaction yields were over 65%. The structures of new compounds were identified by IR, 1H NMR, MS and elemental analyses. Bioassay indicated that, most of 15 new compounds synthesized had confirmed bioactivities inhibition against NOS.
authors.affiliation: School of Chemistry and Environment Science, Nanjing Normal University, Nanjing 210097, China. zhngdayong@yahoo.com
authors.forename: Da-yong
authors.initials: DY
authors.lastname: Zhang
authors.forename: Hua
authors.initials: H
authors.lastname: Xiang
authors.forename: Yun-gen
authors.initials: YG
authors.lastname: Xu
authors.forename: Wei-yi
authors.initials: WY
authors.lastname: Hua
mesh_terms: D015394:Molecular Structure; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D013329:Structure-Activity Relationship; D013844:Thiazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013890:Thiourea / Q000031:analogs & derivatives
chemical_list: D013844:Thiazoles; D019001:Nitric Oxide Synthase; D013890:Thiourea