title: Timing of placental delivery to prevent post-partum haemorrhage: lessons learned from an abandoned randomised clinical trial.
abstract: It has been recognised that, if the length of the third stage of labour exceeds 30 min, then there is an increased risk of a post-partum haemorrhage. Recent information has suggested that 18 min is the optimal time for removal of the undelivered placenta to prevent a post-partum haemorrhage. A randomised trial comparing 20 vs. 30 min was stopped after an interim analysis because only eight of 1607 patients' placentas had not delivered by 20 min. A third stage of labour that exceeded 10 min was observed to be significantly correlated with an increased risk of post-partum haemorrhage.
authors.affiliation: Department of Obstetrics, Naval Medical Center Portsmouth, Portsmouth, Virginia, USA.
authors.forename: Everett F
authors.initials: EF
authors.lastname: Magann
authors.forename: Dorota A
authors.initials: DA
authors.lastname: Doherty
authors.forename: Christian M
authors.initials: CM
authors.lastname: Briery
authors.forename: Amy
authors.initials: A
authors.lastname: Niederhauser
authors.forename: John C
authors.initials: JC
authors.lastname: Morrison
mesh_terms: D000328:Adult; D036861:Delivery, Obstetric / Q000379:methods*; D005260:Female; D006801:Humans; D007749:Labor Stage, Third; D006473:Postpartum Hemorrhage / Q000517:prevention & control*; D011247:Pregnancy; D016032:Randomized Controlled Trials as Topic; D013997:Time Factors