title: Serum triglycerides and colorectal adenoma in a case-control study among cancer screening examinees (Japan).
abstract: OBJECTIVE
  Most epidemiologic studies have shown serum triglycerides to be associated with colorectal adenoma. However, whether the association can be modified by smoking is unknown. We cross-sectionally investigated the association of serum triglycerides with the risk of adenoma by smoking status.
  
  
  METHODS
  We identified 782 newly diagnosed adenoma cases from the examinees of a colorectal cancer screening program. All cases were diagnosed by a magnifying colonoscopy with dye spreading. We determined 738 controls without present illness or past history of adenoma from among the examinees. They provided their lifestyle information and fasting blood samples to measure their serum triglycerides. We calculated odds ratios (OR) and 95% confidence intervals (CI) of colorectal adenoma for serum triglycerides.
  
  
  RESULTS
  High serum triglycerides were associated with colorectal adenoma (OR 1.5; 95% CI 1.1-2.0 for the highest versus the lowest quartile, P (trend, )0.030). A stronger association was observed between three or more adenoma cases and study controls (OR 2.3; 95% CI 1.3-4.2, P (trend,) < 0.0010). After classifying the study subjects by smoking status, a significant linear risk trend was found in ever-smokers (P (trend), 0.0018) but not in never-smokers (P (trend), 0.94; P (interaction), 0.067).
  
  
  CONCLUSIONS
  Our results suggested that a higher serum triglyceride level may be related to a larger number of adenomas. Adenoma development involving an elevated serum triglyceride level may be modified by smoking.
authors.affiliation: Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan. tetsuya-otani@umin.ac.jp
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Otani
authors.forename: Motoki
authors.initials: M
authors.lastname: Iwasaki
authors.forename: Shinobu
authors.initials: S
authors.lastname: Ikeda
authors.forename: Takahiro
authors.initials: T
authors.lastname: Kozu
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Saito
authors.forename: Michihiro
authors.initials: M
authors.lastname: Mutoh
authors.forename: Keiji
authors.initials: K
authors.lastname: Wakabayashi
authors.forename: Shoichiro
authors.initials: S
authors.lastname: Tsugane
mesh_terms: D000236:Adenoma / Q000097:blood* / Q000175:diagnosis*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000097:blood* / Q000175:diagnosis*; D016001:Confidence Intervals; D005260:Female; D006801:Humans; D007564:Japan; D008297:Male; D008403:Mass Screening; D008875:Middle Aged; D016017:Odds Ratio; D012907:Smoking; D014280:Triglycerides / Q000097:blood*
chemical_list: D014280:Triglycerides