title: Synthesis and cytotoxic activities of 4,5-diarylisoxazoles.
abstract: A series of 4,5-diarylisoxazoles related to combretastatin A-4 (CA-4) were synthesized and evaluated for cytotoxicity against three human cancer cell lines. Among them, compound 6e showed better cytotoxic activity than CA-4 in HeLa and HepG2 cell lines assayed with IC(50) value as low as 0.022 and 0.065nM, respectively.
authors.affiliation: National Research Institute of Chinese Medicine, No. 155-1, Section 2, Li-Nung Street, Peitou, Taipei 112, Taiwan, ROC.
authors.forename: Chang-Ming
authors.initials: CM
authors.lastname: Sun
authors.forename: Lee-Gin
authors.initials: LG
authors.lastname: Lin
authors.forename: Hsi-Jung
authors.initials: HJ
authors.lastname: Yu
authors.forename: Chih-Yu
authors.initials: CY
authors.lastname: Cheng
authors.forename: Ya-Chuan
authors.initials: YC
authors.lastname: Tsai
authors.forename: Chi-Wei
authors.initials: CW
authors.lastname: Chu
authors.forename: Yi-Hui
authors.initials: YH
authors.lastname: Din
authors.forename: Yat-Pang
authors.initials: YP
authors.lastname: Chau
authors.forename: Ming-Jaw
authors.initials: MJ
authors.lastname: Don
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002453:Cell Cycle / Q000187:drug effects; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D006801:Humans; D007202:Indicators and Reagents; D007555:Isoxazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D007202:Indicators and Reagents; D007555:Isoxazoles