Prognostic significance of the expression of SR-A1, encoding a novel SR-related CTD-associated factor, in breast cancer.
SR-A1 is a human high-molecular-weight SR-related CTD-associated factor that links the machineries of transcription and mRNA splicing. In this study we examined the prognostic value of SR-A1 gene expression using a semi-quantitative RT-PCR method. High SR-A1 expression was observed in 31/81 (38.3%) breast cancer tissues and was found to be more frequent in patients with tumors of large size (p=0.027), as well as in lymph node-positive patients (p=0.035). Follow-up analysis revealed that low SR-A1 expression increases the probability of both overall and disease-free survival of patients. Our results suggest that SR-A1 may possibly be characterized as a new marker of unfavorable prognosis for breast cancer.
Leoutsakou
Theoni
T
Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Athens, GR-15711 Athens, Greece.
Talieri
Maroulio
M
Scorilas
Andreas
A
D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology; D002352:Carrier Proteins / Q000235:genetics*; D005260:Female; D006801:Humans; D011379:Prognosis; D012326:RNA Splicing; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D000068103:Serine-Arginine Splicing Factors; D016019:Survival Analysis
D002352:Carrier Proteins; D012333:RNA, Messenger; C503566:SCAF1 protein, human; D000068103:Serine-Arginine Splicing Factors