Human papillomavirus prevalence in women who have and have not undergone hysterectomies.
We compared human papillomavirus (HPV) prevalence in an age-stratified random sample of women who have undergone a hysterectomy (WH) (n=573) with the HPV prevalence in age-matched women with intact cervices (women who have not undergone a hysterectomy [WNH]) (n=581) participating in a study at Kaiser Permanente in Portland, Oregon. Testing cervicovaginal lavage fluids for >40 HPV genotypes using an MY09/11 L1 consensus primer polymerase chain reaction method, we found no statistical differences in the prevalence of HPV (16% for WNH vs. 13.9% for WH) or carcinogenic HPV (6.5% for WNH vs. 4.5% for WH) between the 2 groups of women. Although WH have a similar prevalence of carcinogenic HPV infection, compared with WNH without a cervix, they have minimal risk of HPV-induced cancer and are unlikely to benefit from HPV testing.
Castle
Philip E
PE
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD, USA. castlep@mail.nih.gov
Schiffman
Mark
M
Glass
Andrew G
AG
Rush
Brenda B
BB
Scott
David R
DR
Wacholder
Sholom
S
Dunn
Anne
A
Burk
Robert D
RD
D000328:Adult; D000368:Aged; D017931:DNA Primers; D004279:DNA, Viral / Q000235:genetics; D005260:Female; D052162:Human papillomavirus 16 / Q000235:genetics / Q000302:isolation & purification; D006801:Humans; D007044:Hysterectomy; D008875:Middle Aged; D009922:Oregon; D027383:Papillomaviridae / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000601:surgery / Q000821:virology*; D016133:Polymerase Chain Reaction; D013045:Species Specificity; D002583:Uterine Cervical Neoplasms / Q000601:surgery / Q000821:virology*; D014621:Vagina / Q000821:virology*; D044364:Vaginal Douching
D017931:DNA Primers; D004279:DNA, Viral