title: [Spontaneous discharge modulation by acetylcholine in chronically compressed rat dorsal root ganglion neurons].
abstract: OBJECTIVE
  To study the effects of acetylcholine (ACh) on spontaneous discharges of compressed rat dorsal root ganglion (DRG) neurons.
  
  
  METHODS
  In chronically compressed DRG model, the spontaneous discharge of a single fiber from the DRG neuron in response to ACh treatment was recorded.
  
  
  RESULTS
  Active spontaneous discharges were recorded in the injured DRG, and 77.9% of the injured DRG neurons responded to Ach treatment in the manner of simple excitation, or excitation followed by inhibition. The responses were enhanced with the increase of Ach concentration.
  
  
  CONCLUSIONS
  Injured DRG remains active in spontaneous discharges, which can be significantly influenced by ACh treatment.
authors.affiliation: Department of Neurology, Guangzhou General Hospital of Guangzhou Command, Guangzhou 510010, China. sjnkyhj@163.com
authors.forename: Hong-Jun
authors.initials: HJ
authors.lastname: Yang
authors.forename: San-Jue
authors.initials: SJ
authors.lastname: Hu
mesh_terms: D000109:Acetylcholine / Q000494:pharmacology*; D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D005727:Ganglia, Spinal / Q000503:physiopathology*; D008297:Male; D009408:Nerve Compression Syndromes / Q000503:physiopathology*; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors; D014665:Vasodilator Agents / Q000494:pharmacology
chemical_list: D014665:Vasodilator Agents; D000109:Acetylcholine