Low genetic diversity of the intrinsic OXA-51-like class D carbapenemases among Acinetobacter baumannii clinical isolates in Greece.
This study examined the geographical distribution and diversity of the intrinsic OXA-51-like class D carbapenemases among Acinetobacter baumannii clones recovered in three major Greek regions from 2000 to 2005. The blaOXA-66 allele was exclusively detected among clonally distinct A. baumannii isolates recovered in the regions of Thessaloniki and Larissa. This sequence was also the most widespread among A. baumannii isolates in Athens, while less frequent were blaOXA-69 and blaOXA-65 alleles. These findings highlight the high prevalence of a specific blaOXA-51-like allele in Greece, possibly indicating that our A. baumannii clones might have originated from a common ancestor. However, the possibility that blaOXA-51-like variants, with blaOXA-66 predominating, are widely disseminated among several unrelated A. baumannii strains cannot be excluded.
Ikonomidis
A
A
Department of Clinical Microbiology, University of Thessalia, Mezourlo, Larissa, Greece.
Pournaras
S
S
Markogiannakis
A
A
Maniatis
A N
AN
Manolis
E N
EN
Tsakris
A
A
D040981:Acinetobacter baumannii / Q000187:drug effects / Q000201:enzymology*; D001426:Bacterial Proteins / Q000235:genetics*; D016521:Electrophoresis, Gel, Pulsed-Field; D014644:Genetic Variation; D006115:Greece; D006801:Humans; D008826:Microbial Sensitivity Tests; D001618:beta-Lactamases / Q000235:genetics*
D001426:Bacterial Proteins; D001618:beta-Lactamases; C063912:carbapenemase