title: Factors affecting the degradation of amoxicillin in composting toilet.
abstract: The biological and non-biological factors that affect the degradation of amoxicillin in the composting process of feces have been investigated. The effect of living bacteria and the enzyme (beta-lactamase) on amoxicillin decay was examined, and our results indicated that the biological effects are likely to be negligible. Consequently, the effect of phosphate, ammonia and pH level as non-biological factors was investigated by monitoring the reduction rate of amoxicillin in phosphate and ammonia buffer solutions with several pH levels. Each reduction rate constant was integrated by a simulation model, and the each calculated amoxicillin reduction profile was compared to the reduction profiles of amoxicillin in the composting process of feces. The calculated results corresponded almost exactly to the experimental profiles. We therefore concluded that the degradation of amoxicillin in a toilet matrix was dependent on the concentration of ammonia, phosphate and hydroxyl ion.
authors.affiliation: Division of Built Environment, Graduate School of Engineering, Hokkaido University, Kita13 Nishi8, Kita-ku, Sapporo, Hokkaido 060-8628, Japan. kakimoto@eng.hokudai.ac.jp
authors.forename: Takashi
authors.initials: T
authors.lastname: Kakimoto
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Funamizu
mesh_terms: D000641:Ammonia / Q000737:chemistry; D000658:Amoxicillin / Q000737:chemistry* / Q000378:metabolism; D001419:Bacteria / Q000378:metabolism; D004553:Electric Conductivity; D005243:Feces / Q000737:chemistry* / Q000382:microbiology; D006801:Humans; D006863:Hydrogen-Ion Concentration; D006878:Hydroxides / Q000737:chemistry; D010710:Phosphates / Q000737:chemistry; D014865:Waste Disposal, Fluid; D014874:Water Pollutants, Chemical / Q000737:chemistry* / Q000378:metabolism; D014934:Wood; D001618:beta-Lactamases / Q000378:metabolism
chemical_list: D006878:Hydroxides; D010710:Phosphates; D014874:Water Pollutants, Chemical; D000641:Ammonia; D000658:Amoxicillin; C031356:hydroxide ion; D001618:beta-Lactamases