title: Helicobacter pylori adhesion to carbohydrates.
abstract: Adherence of bacterial pathogens to host tissues contributes to colonization and virulence and typically involves specific interactions between bacterial proteins called adhesins and cognate oligosaccharide (glycan) or protein motifs in the host that are used as receptors. A given pathogen may have multiple adhesins, each specific for a different set of receptors and, potentially, with different roles in infection and disease. This chapter provides strategies for identifying and analyzing host glycan receptors and the bacterial adhesins that exploit them as receptors, with particular reference to adherence of the gastric pathogen Helicobacter pylori.
authors.affiliation: Department of Molecular Biosciences, University of Oslo, Oslo, Norway.
authors.forename: Marina
authors.initials: M
authors.lastname: Aspholm
authors.forename: Awdhesh
authors.initials: A
authors.lastname: Kalia
authors.forename: Stefan
authors.initials: S
authors.lastname: Ruhl
authors.forename: Staffan
authors.initials: S
authors.lastname: Schedin
authors.forename: Anna
authors.initials: A
authors.lastname: Arnqvist
authors.forename: Sara
authors.initials: S
authors.lastname: Lindén
authors.forename: Rolf
authors.initials: R
authors.lastname: Sjöström
authors.forename: Markus
authors.initials: M
authors.lastname: Gerhard
authors.forename: Cristina
authors.initials: C
authors.lastname: Semino-Mora
authors.forename: Andre
authors.initials: A
authors.lastname: Dubois
authors.forename: Magnus
authors.initials: M
authors.lastname: Unemo
authors.forename: Dan
authors.initials: D
authors.lastname: Danielsson
authors.forename: Susann
authors.initials: S
authors.lastname: Teneberg
authors.forename: Woo-Kon
authors.initials: WK
authors.lastname: Lee
authors.forename: Douglas E
authors.initials: DE
authors.lastname: Berg
authors.forename: Thomas
authors.initials: T
authors.lastname: Borén
mesh_terms: D001422:Bacterial Adhesion / Q000502:physiology*; D050260:Carbohydrate Metabolism; D016480:Helicobacter pylori / Q000502:physiology*; D006801:Humans