title: [Effects of xinshuai mistura on plasma angiotensin II, atrial natriuretic peptide and N terminal pro-brain natriuretic peptide in patients with heart failure].
abstract: OBJECTIVE
  To observe the effects of Xinshuai Mistura (XM) on plasma angiotensin II (Ang II), atrial natriuretic peptide (ANP) and N terminal pro- brain natriuretic peptide (Nt-proBNP) in patients with heart failure (HF).
  
  
  METHODS
  Fifty-nine patients with HF (NYHA class II-IV) were randomly divided into two groups, the treated group treated with XM and the control group with Wuling Pulvis (WP), both on the base of captopril treatment. The treatment course was two weeks. Plasma levels of Ang II , ANP and Nt-proBNP were observed.
  
  
  RESULTS
  The plasma levels of Ang I, ANP and Nt-proBNP showed an ascending tendency along with the increasing in severity of HF(P < 0.01), and significantly decreased after treatment in the treated group (P < 0.01), but with no remarkable difference as compared with those in the control group (P > 0.05).
  
  
  CONCLUSIONS
  XM had definite therapeutic effects on excessive neuroendocrine activation in HF patients.
authors.forename: Mei
authors.initials: M
authors.lastname: Dai
authors.forename: Qing-xiang
authors.initials: QX
authors.lastname: Wen
authors.forename: Jun-ren
authors.initials: JR
authors.lastname: He
mesh_terms: D000328:Adult; D000368:Aged; D000804:Angiotensin II / Q000097:blood*; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D009320:Atrial Natriuretic Factor / Q000097:blood*; D002216:Captopril / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006333:Heart Failure / Q000097:blood / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D008517:Phytotherapy; D016037:Single-Blind Method; D016896:Treatment Outcome
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D004365:Drugs, Chinese Herbal; D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); C526706:xinshuai mistura; D000804:Angiotensin II; D020097:Natriuretic Peptide, Brain; D009320:Atrial Natriuretic Factor; D002216:Captopril