title: Outcome of acute vertebrobasilar occlusions treated with intra-arterial fibrinolysis in 180 patients.
abstract: OBJECTIVE
  To evaluate predictors of recanalization and a favorable neurologic outcome in patients with acute vertebrobasilar occlusion (VBO) treated with local intra-arterial fibrinolysis (LIF).
  
  
  METHODS
  The multicentric data of 180 patients with acute VBO treated with LIF were retrospectively evaluated. The modified Rankin scale (mRS) was used to evaluate the neurologic status before LIF and at the time of discharge. Patient's sex, age, etiology of VBO, recanalization, symptom duration before LIF, and pretreatment mRS were correlated with posttreatment mRS. Multiple logistic regression analysis was used to identify independent variables for recanalization and neurologic outcome.
  
  
  RESULTS
  The overall mortality was 43%. Complete recanalization was achieved in 99 (55%) patients and a partial recanalization in 35 (19%) patients, respectively. Recanalization was significantly associated with a favorable outcome (P < .001). The success of recanalization was negatively correlated with the volume of the thrombus (P < .001). No correlation was found between site and etiology of VBO and recanalization. Neurologic outcome correlated strongly with the pretreatment mRS (P < .001) and also with age (P < .02). Coma lasting less than 4.5 hours led to a positive trend toward a better outcome after univariate testing (P < .001).
  
  
  CONCLUSIONS
  Success of recanalization and neurologic status before treatment predict neurologic outcome in patients with VBO. Thrombus volume has an adverse effect on the recanalization success.
authors.affiliation: Department of Neuroradiology, University of Munich, Klinikum Grosshadern, Germany. gernot.sad@gmx.de
authors.forename: G
authors.initials: G
authors.lastname: Schulte-Altedorneburg
authors.forename: G F
authors.initials: GF
authors.lastname: Hamann
authors.forename: M
authors.initials: M
authors.lastname: Mull
authors.forename: D
authors.initials: D
authors.lastname: Kühne
authors.forename: M
authors.initials: M
authors.lastname: Liebetrau
authors.forename: W
authors.initials: W
authors.lastname: Weber
authors.forename: H
authors.initials: H
authors.lastname: Brückmann
authors.forename: T E
authors.initials: TE
authors.lastname: Mayer
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005343:Fibrinolytic Agents / Q000008:administration & dosage*; D006801:Humans; D007269:Injections, Intra-Arterial; D008297:Male; D008875:Middle Aged; D011994:Recombinant Proteins / Q000008:administration & dosage; D012189:Retrospective Studies; D015912:Thrombolytic Therapy / Q000379:methods; D010959:Tissue Plasminogen Activator / Q000008:administration & dosage*; D016896:Treatment Outcome; D014715:Vertebrobasilar Insufficiency / Q000188:drug therapy*
chemical_list: D005343:Fibrinolytic Agents; D011994:Recombinant Proteins; D010959:Tissue Plasminogen Activator