Structural determinants of T-cell receptor bias in immunity.
Antigen-specific T-cell responses induced by infection, transplantation, autoimmunity or hypersensitivity are characterized by cells expressing biased profiles of T-cell receptors (TCRs) that are selected from a diverse, naive repertoire. Here, we review the evidence for these TCR biases, focusing on crystallographic analysis of the structural constraints that determine the binding of a TCR to its ligand and the persistence of certain TCRs in an immune repertoire. We discuss the ways in which diversity in a selected TCR repertoire can contribute to protective immunity and the implications of this for vaccine design and immunotherapy.
Turner
Stephen J
SJ
Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria 3010, Australia. sjturn@unimelb.edu.au
Doherty
Peter C
PC
McCluskey
James
J
Rossjohn
Jamie
J
D000818:Animals; D014644:Genetic Variation; D006801:Humans; D007109:Immunity / Q000235:genetics; D051379:Mice; D011487:Protein Conformation; D011948:Receptors, Antigen, T-Cell / Q000737:chemistry* / Q000235:genetics* / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*; D014780:Viruses / Q000276:immunology*
D011948:Receptors, Antigen, T-Cell