Mooloolabenes A-E, norsesterterpenes from the Australian sponge Hyattella intestinalis.
Five new norsesterterpenes, mooloolabenes A-E (1-5), and the new sesterterpene mooloolaldehyde (6), related to the scalarane family of compounds, were isolated from an acetone extract of the Australian sponge Hyattella intestinalis. Structural elucidation, including relative stereochemical assignment, was based on spectroscopic analysis. All compounds tested showed cytotoxic activity against the P388 cell line.
Somerville
Michael J
MJ
School of Molecular and Microbial Sciences, The University of Queensland, Brisbane QLD 4072, Australia.
Hooper
John N A
JN
Garson
Mary J
MJ
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001315:Australia; D004354:Drug Screening Assays, Antitumor; D007941:Leukemia P388; D051379:Mice; D015394:Molecular Structure; D054830:Sesterterpenes; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D000970:Antineoplastic Agents; D054830:Sesterterpenes; D013729:Terpenes; C516619:mooloolaldehyde