Marine sponge metabolites for the control of inflammatory diseases.
Marine organisms are a rich source of bioactive metabolites. A number of potential anti-inflammatory compounds have been isolated from marine invertebrates that exhibit phospholipase A2 inhibitory activity. A wide range of marine compounds have been investigated for their anti-inflammatory properties. Cacospongionolide B and petrosaspongiolide M are representative examples of anti-inflammatory compounds in experimental models of acute or chronic inflammation. The mechanisms of action of these compounds include phospholipase A, inhibition as well as the control of nuclear factor-B activation and inflammatory gene expression. Although many marine compounds exhibit interesting anti-inflammatory properties, few have entered clinical trials. The future development of this class of compounds as anti-inflammatory drugs requires the introduction of novel molecular targets of therapeutic relevance in addition to biotechnological approaches for the production of these molecules.
Alcaraz
Maria José
MJ
University of Valencia, Department of Pharmacology, Av Vicent Andres Estelles s/n, 46100 Burjasot, Valencia, Spain. maria.j.alcaraz@uv.es
Payá
Miguel
M
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004353:Drug Evaluation, Preclinical; D006801:Humans; D007249:Inflammation / Q000517:prevention & control*; D015394:Molecular Structure; D011161:Porifera / Q000737:chemistry* / Q000378:metabolism; D013678:Technology, Pharmaceutical / Q000379:methods / Q000639:trends; D016896:Treatment Outcome
D000893:Anti-Inflammatory Agents