Comparative study of intranasal midazolam and intravenous diazepam sedation for procedures and seizures.
OBJECTIVE
To evaluate the safety and efficacy of intranasal midazolam for seizures and various procedures.


METHODS
Prospective randomized study. Total 125 children of all ages of either sex, for seizure episode (n-76) and various invasive and non-invasive procedures (n-49) received either intranasal midazolam (0.2 mg/Kg) or intravenous diazepam (0.3 mg/Kg). RESULTS. Mean time from arrival at hospital to starting treatment was significantly shorter in midazolam group compared to diazepam group [2.34+/-0.90; minute vs 4.61+/-1.08 minute p< 0.001]. Mean time to control seizures after arrival in hospital was significantly shorter in midazolam group compared to diazepam group [5.25+/-0.86 minute vs 6.51+/-1.06 minute p.


CONCLUSIONS
Midazolam by the intranasal route provides safe and equally effective non-invasive method of sedation for procedures and seizures.
Mittal
Pankaj
P
Department of Pediatrics, S.S. Medical College and G.M. Hospital, Rewa, India.
Manohar
Ram
R
Rawat
A K
AK
D000281:Administration, Intranasal; D002648:Child; D002675:Child, Preschool; D016292:Procedural Sedation; D003975:Diazepam / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage*; D007223:Infant; D007231:Infant, Newborn; D007262:Infusions, Intravenous; D008297:Male; D008874:Midazolam / Q000008:administration & dosage*; D011446:Prospective Studies; D012640:Seizures / Q000188:drug therapy
D006993:Hypnotics and Sedatives; D003975:Diazepam; D008874:Midazolam