[The PAI-1 swing: microenvironment and cancer cell migration].
Cancer is a complex and dynamic process caused by a cellular dysfunction leading to a whole organ or even organism vital perturbation. To better understand this process, we need to study each one of the levels involved, which allows the scale change, and to integrate this knowledge. A matricellular protein, PAI-1, is able to induce in vitro cell behaviour modifications, morphological changes, and to promote cell migration. PAI-1 influences the mesenchymo-amaeboid transition. This matricellular protein should be considered as a potential 'launcher' of the metastatic process acting at the molecular, cellular, tissular levels and, as a consequence, at the organism's level.
Malo
Michel
M
Equipe DYNAMIC, Dynamique du Microenvironnement Cellulaire, Informatique, Biologie Intégrative et Systèmes Complexes), FRE 2873 CNRS, Université d'Evry-Val d'Essonne, Université Paris 12, Génopole, France.
Charrière-Bertrand
Cécile
C
Chettaoui
Chafika
C
Fabre-Guillevin
Elizabeth
E
Maquerlot
François
F
Lackmy
Alexandra
A
Vallée
Benoît
B
Delaplace
Franck
F
Barlovatz-Meimon
Georgia
G
D002448:Cell Adhesion / Q000502:physiology*; D002465:Cell Movement / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D009369:Neoplasms / Q000235:genetics / Q000473:pathology / Q000503:physiopathology*; D017395:Plasminogen Activator Inhibitor 1 / Q000502:physiology*; D012333:RNA, Messenger / Q000235:genetics
D017395:Plasminogen Activator Inhibitor 1; D012333:RNA, Messenger