title: On the role of specific chaperones, the specific ATPase, and the proton motive force in type III secretion.
abstract: Type III secretion systems (T3SSs) are engaged by a broad number of Gram-negative bacteria to inject proteins into host cells. The simultaneous crossing of three biological membranes by these proteins is a phenomenon which is far from being understood mechanistically. However, recent work from several groups has substantially enriched our conception of how proteins travel from the bacterial into the host cell cytosol. Here, we focus on the role of specific T3SS chaperones, the specific ATPase, and the proton motive force in type III secretion.
authors.affiliation: Max von Pettenkofer-Institut, Lehrstuhl für Bakteriologie, Ludwig-Maximilians-Universität München, Pettenkoferstrasse 9a, D-80336 Munich, Germany. wilharm@mvp.uni-muenchen.de
authors.forename: Gottfried
authors.initials: G
authors.lastname: Wilharm
authors.forename: Svea
authors.initials: S
authors.lastname: Dittmann
authors.forename: Annika
authors.initials: A
authors.lastname: Schmid
authors.forename: Jürgen
authors.initials: J
authors.lastname: Heesemann
mesh_terms: D000251:Adenosine Triphosphatases / Q000378:metabolism*; D001426:Bacterial Proteins / Q000378:metabolism*; D006090:Gram-Negative Bacteria / Q000378:metabolism*; D018832:Molecular Chaperones / Q000502:physiology*; D021381:Protein Transport; D018892:Proton-Motive Force; D037521:Virulence Factors / Q000378:metabolism*
chemical_list: D001426:Bacterial Proteins; D018832:Molecular Chaperones; D037521:Virulence Factors; D000251:Adenosine Triphosphatases