title: Entomogenous fungi that produce 2,6-pyridine dicarboxylic acid (dipicolinic acid).
abstract: An inhibitor of the prophenoloxidase activation using extract from a silkworm pupa was isolated from a culture filtrate of Cordyceps militaris and identified as dipicolinic acid (DPA). The production of DPA in Clavicipitaceae fungi was examined. Entomogenous fungi that produce DPA were integrated into one group by a phylogenetic analysis based on 18S rDNA. It is suggested that the group acquired an ability to produce DPA during its evolution from plant pathogenic fungi to entomogenous fungi.
authors.affiliation: Department of Applied Biological Chemistry, Faculty of Agriculture, Meijo University, 1-501 Shiogamaguchi, Tempaku-ku, Nagoya 468-8502, Japan.
authors.forename: Nobuko
authors.initials: N
authors.lastname: Watanabe
authors.forename: Maki
authors.initials: M
authors.lastname: Hattori
authors.forename: Eiji
authors.initials: E
authors.lastname: Yokoyama
authors.forename: Shigeki
authors.initials: S
authors.lastname: Isomura
authors.forename: Minoru
authors.initials: M
authors.lastname: Ujita
authors.forename: Akira
authors.initials: A
authors.lastname: Hara
mesh_terms: D000818:Animals; D032661:Cordyceps / Q000145:classification* / Q000235:genetics / Q000378:metabolism*; D007313:Insecta / Q000382:microbiology; D010848:Picolinic Acids / Q000378:metabolism*; D013045:Species Specificity
chemical_list: D010848:Picolinic Acids; C004860:dipicolinic acid