title: Anti-ulcer activity of crude alcoholic extract of Toona ciliata Roemer (heart wood).
abstract: The ethanol extract of Toona ciliata Roemer (heart wood) was evaluated for its anti-ulcer activity against aspirin plus pylorous ligation induced gastric ulcer (antisecretory), HCl-ethanol induced ulcer (cytoprotective) and water immersion stress induced ulcer in rats. We found that Toona ciliata extract at a dose of 300mg/kg p.o. markedly decrease the incidence of ulcers in all the three models. Ethanol extract of Toona ciliata showed significant reduction in gastric volume, free acidity, total acidity and ulcer index. The plant extract also showed gastro protective activity (52.94%), whereas standard drug sucralfate showed 94.85%. Toona ciliata extract showed protection index 43.0% in water immersion stress induced ulcer, whereas standard drug omeprazole showed protection index 100%.
authors.affiliation: C.L. Baid Metha College of Pharmacy, Thoraipakkam, Chennai 600096, Tamilnadu, India. pmalairajan@yahoo.co.in
authors.forename: P
authors.initials: P
authors.lastname: Malairajan
authors.forename: Geetha
authors.initials: G
authors.lastname: Gopalakrishnan
authors.forename: S
authors.initials: S
authors.lastname: Narasimhan
authors.forename: K Jessi Kala
authors.initials: KJ
authors.lastname: Veni
authors.forename: S
authors.initials: S
authors.lastname: Kavimani
mesh_terms: D000818:Animals; D000897:Anti-Ulcer Agents / Q000627:therapeutic use; D001241:Aspirin / Q000633:toxicity; D004195:Disease Models, Animal; D000431:Ethanol; D005260:Female; D008026:Ligation; D008297:Male; D008519:Medicine, Traditional; D029582:Meliaceae; D009853:Omeprazole / Q000627:therapeutic use; D008517:Phytotherapy; D024301:Plant Bark; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal; D051381:Rats; D017208:Rats, Wistar; D013276:Stomach Ulcer / Q000188:drug therapy*; D013312:Stress, Physiological / Q000150:complications; D013392:Sucralfate / Q000627:therapeutic use
chemical_list: D000897:Anti-Ulcer Agents; D010936:Plant Extracts; D000431:Ethanol; D013392:Sucralfate; D009853:Omeprazole; D001241:Aspirin