title: Tear glucose dynamics in diabetes mellitus.
abstract: This study compares tear glucose dynamic differences between 121 diabetic and nondiabetic subjects after the administration of a carbohydrate load. A quantitative chromatographic analysis of tear glucose was used and the values correlated to blood glucose values. Diabetic and nondiabetic tear glucose mean values were 0.35 +/- 0.04 mmol/L and 0.16 +/- 0.03 mmol/L, respectively. Significant differences were observed among the subject groups in both the tear and capillary blood glucose values. A correlation between tear glucose and capillary blood glucose was observed. The concentration of glucose in the tear fluid changes proportionately with respect to capillary blood glucose after a carbohydrate challenge. Although it is possible to determine the diabetic status of a subject using tear glucose values alone, in the clinical setting this may not prove to be practical due to technical limitations.
authors.affiliation: CIBA Vision Corporation, Duluth, GA, USA.
authors.forename: Jennifer D
authors.initials: JD
authors.lastname: Lane
authors.forename: David M
authors.initials: DM
authors.lastname: Krumholz
authors.forename: Robert A
authors.initials: RA
authors.lastname: Sack
authors.forename: Carol
authors.initials: C
authors.lastname: Morris
mesh_terms: D001786:Blood Glucose / Q000032:analysis; D003920:Diabetes Mellitus / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D018670:Monitoring, Ambulatory; D011446:Prospective Studies; D013666:Tears / Q000378:metabolism*
chemical_list: D001786:Blood Glucose; D005947:Glucose