title: Adjacent segment disc pressures following two-level cervical disc replacement versus simulated anterior cervical fusion.
abstract: Anterior cervical fusion (ACF) has been shown to alter the biomechanics of adjacent segments of the cervical spine. The goal of total disc replacement is to address pathology at a given disc with minimal disruption of the operated or adjacent segments. This study compares the pressure within discs adjacent to either a two-level simulated ACDF or a two-level total disc replacement with the ProDisc-C. A special automated motion testing apparatus was constructed. Four fresh cadaveric cervical spine specimens were affixed to the test stand and tested in flexion and extension under specific loads. Intradiscal, miniature strain-gauge-based transducers were placed in the discs above and below the "treated" levels. The specimens were then tested in flexion and extension. Pressure and overall angular displacement were measured. In the most extreme and highest quality specimen the difference at C3/C4 registered 800 kPa and the difference at C6/C7 registered 50 kPa. This same quality specimen treated with the ProDisc reached a flexion angle at much lower moments, 24.3 degrees at 5 N-m, when compared to the the SACF 12.2 degrees at 8.6 N-m. Therefore, the moment needed to achieve 15 degrees of flexion with the SACF treatment was 5.5 N-m and the ProDisc treatment was only 2.9 N-m. This initial data would indicate that adjacent level discs experience substantially lower pressure after two-level disc replacement when compared to two-level SACF. Additional testing to further support these observations is ongoing.
authors.affiliation: Charlotte Spine Center of Ortho Carolina and Charlotte Orthopedic Research Institute, USA.
authors.forename: Eric B
authors.initials: EB
authors.lastname: Laxer
authors.forename: Bruce V
authors.initials: BV
authors.lastname: Darden
authors.forename: Daniel B
authors.initials: DB
authors.lastname: Murrey
authors.forename: R Alden
authors.initials: RA
authors.lastname: Milam
authors.forename: Alfred L
authors.initials: AL
authors.lastname: Rhyne
authors.forename: Brian
authors.initials: B
authors.lastname: Claytor
authors.forename: Donna S
authors.initials: DS
authors.lastname: Nussman
authors.forename: Timothy W
authors.initials: TW
authors.lastname: Powers
authors.forename: Matthew A
authors.initials: MA
authors.lastname: Davies
authors.forename: S Chad
authors.initials: SC
authors.lastname: Bryant
authors.forename: Scott P
authors.initials: SP
authors.lastname: Larsen
authors.forename: Meghal
authors.initials: M
authors.lastname: Bhatt
authors.forename: John
authors.initials: J
authors.lastname: Brodziak
authors.forename: Jelena
authors.initials: J
authors.lastname: Polic
mesh_terms: D001696:Biomechanical Phenomena; D002102:Cadaver; D002574:Cervical Vertebrae / Q000601:surgery*; D004867:Equipment Design; D006801:Humans; D013123:Spinal Fusion; D014481:United States; D016474:Weight-Bearing / Q000502:physiology*