title: Vibralactone: a lipase inhibitor with an unusual fused beta-lactone produced by cultures of the basidiomycete Boreostereum vibrans.
abstract: The structure and absolute configuration of vibralactone (1) from the cultures of the Basidiomycete Boreostereum vibrans were established by spectroscopic methods and computational methods. Vibralactone, an unusual fused beta-lactone-type metabolite, was found to inhibit pancreatic lipase with an IC50 of 0.4 microg/mL. [structure: see text]
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, P.R. China.
authors.forename: Dong-Ze
authors.initials: DZ
authors.lastname: Liu
authors.forename: Fei
authors.initials: F
authors.lastname: Wang
authors.forename: Tou-Gen
authors.initials: TG
authors.lastname: Liao
authors.forename: Jian-Guo
authors.initials: JG
authors.lastname: Tang
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Steglich
authors.forename: Hua-Jie
authors.initials: HJ
authors.lastname: Zhu
authors.forename: Ji-Kai
authors.initials: JK
authors.lastname: Liu
mesh_terms: D001487:Basidiomycota / Q000378:metabolism*; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology; D007783:Lactones / Q000737:chemistry* / Q000494:pharmacology; D008049:Lipase / Q000037:antagonists & inhibitors*; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared
chemical_list: D004791:Enzyme Inhibitors; D007783:Lactones; C522315:vibralactone; D008049:Lipase