MicroRNAs and genomic instability.
A new species of non-coding RNA, microRNAs (miRNAs) has been identified that may regulate the expression of as many as one third to one half of all protein encoding genes. MicroRNAs are found throughout mammalian genomes, but an association between the location of these miRNAs and regions of genomic instability (or fragile sites) in humans has been suggested [1]. In this review we discuss the possible role of altered miRNA expression on human cancer and conduct an analysis correlating the physical location of murine miRNAs with sites of genetic alteration in mouse models of cancer.
Huppi
Konrad
K
Gene Silencing Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. huppi@helix.nih.gov
Volfovsky
Natalia
N
Mackiewicz
Mark
M
Runfola
Timothy
T
Jones
Tamara L
TL
Martin
Scott E
SE
Stephens
Robert
R
Caplen
Natasha J
NJ
D000818:Animals; D019295:Computational Biology / Q000379:methods; D004273:DNA, Neoplasm; D020869:Gene Expression Profiling; D016678:Genome; D015894:Genome, Human; D042822:Genomic Instability; D006801:Humans; D051379:Mice; D035683:MicroRNAs; D008954:Models, Biological; D008957:Models, Genetic; D005810:Multigene Family; D009369:Neoplasms / Q000235:genetics*; D012313:RNA / Q000235:genetics
D004273:DNA, Neoplasm; D035683:MicroRNAs; D012313:RNA