A case of primary cutaneous nasal type NK/T-cell lymphoma and review of the literature.
BACKGROUND
Cutaneous T-cell lymphoma subtypes are now better identified thanks to progress in immunohistochemistry. This article describes a new case of primary cutaneous natural killer/T-cell lymphoma of nasal type (NKTL-NT) and reviews 18 other cases of this rare neoplasm.


METHODS
A 79-year-old man presented with a 3-cm nodular tumor of the left leg occurring on a primary chronic lymphedema of the legs. The lesion was CD56+, CD3 intracytoplasmic+, CD45+ and Epstein-Barr virus+. A comprehensive workup including CT scan and bone marrow biopsy was negative and a diagnosis of NKTL-NT with a primary cutaneous involvement was made. The patient was free of disease under multi-agent chemotherapy after 24 months of follow-up.


CONCLUSIONS
After reviewing 18 other cases of primary cutaneous NKTL-NT, we conclude that the prognosis of these lymphomas is usually poor. However, limited cutaneous forms have a longer median survival than extracutaneous variants.
Stokkermans-Dubois
J
J
Skin and Cancer Unit, Department of Dermatology, Saint André Hospital, Bordeaux, France.
Jouary
T
T
Vergier
B
B
Delaunay
M M
MM
Taieb
A
A
D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D019002:CD56 Antigen / Q000032:analysis; D005500:Follow-Up Studies; D006801:Humans; D007694:Killer Cells, Natural / Q000473:pathology*; D007866:Leg; D017493:Leukocyte Common Antigens / Q000032:analysis; D008209:Lymphedema / Q000175:diagnosis; D016410:Lymphoma, T-Cell, Cutaneous / Q000175:diagnosis* / Q000473:pathology; D008297:Male; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000473:pathology
D019002:CD56 Antigen; D017493:Leukocyte Common Antigens