Long-term outcome of renal transplantation in focal glomerulosclerosis.
BACKGROUND
Focal segmental glomerulosclerosis (FSGS) has a tendency to recur frequently after kidney transplantation. We evaluated 12 cases to examine the incidence and long-term outcomes of recurrent FSGS.


METHODS
Twelve patients with renal failure caused by FSGS received kidney allografts from living related donors. Tacrolimus or cyclosporine was used in combination with prednisolone and azathioprine or mycophenolate mofetil.


RESULTS
The mean graft survival was 87.4 +/- 46.8 months. The graft survival rates in FSGS recipients were at 1 year, 100%; 5 years, 79.6%; 10 years, 68.2%. Two out of four recipients experienced graft loss due to chronic rejection. The other two out of four recipients with graft loss displayed severe proteinuria diagnosed as recurrence of FSGS. To treat recurrent FSGS, plasma exchange was partially effective to reduce proteinuria.


CONCLUSIONS
Our incidence of recurrent FSGS is 16.7% with graft survivals at 5 and 10 years of 79.6% and 68.2%, respectively. The recurrence of FSGS happened after scheduled reductions in immunosuppressants. Careful observation is required with maintenance of immunosuppression in these patients.
Akioka
K
K
Department of Organ Transplant and Endocrine Surgery, Kyoto Prefectural University, Kyoto, Japan. kakioka@koto.kpu-m.ac.jp
Okamoto
M
M
Wakabayashi
Y
Y
Nobori
S
S
Ogino
S
S
Ushigome
H
H
Uryuhara
K
K
Kaihara
S
S
Yoshimura
N
N
D001706:Biopsy; D005190:Family; D005260:Female; D005500:Follow-Up Studies; D005923:Glomerulosclerosis, Focal Segmental / Q000473:pathology / Q000601:surgery*; D006085:Graft Survival; D006801:Humans; D016030:Kidney Transplantation / Q000502:physiology*; D019520:Living Donors; D008297:Male; D014184:Transplantation, Homologous; D016896:Treatment Outcome