Sperm chromosome analysis in two cases of paracentric inversion.
OBJECTIVE
To examine sperm meiotic segregation in men with paracentric inversions.


METHODS
Cases reports, literature review.


METHODS
Departments of reproductive biology, cytogenetics, gynaecology, and obstetrics.


METHODS
Two patients referred for infertility, heterozygous for a paracentric inversion.


METHODS
Fluorescence in situ hybridization (FISH) with specific probes and X/Y/18 centromeric probes on 1,000 spermatozoa for the 2 patients and 10 controls.


METHODS
Sperm aneuploidy frequency.


RESULTS
The FISH analysis using the specific probes for the paracentric inversion indicated low disequilibrium (0.4% and 0.5%). The FISH analysis using X/Y/18 centromeric probes indicated aneuploidy frequencies (0.3% and 1.1%), identical to those of control patients with the same sperm parameters.


CONCLUSIONS
Paracentric inversion seems to be associated with a very low risk of aneuploidy. A larger study is necessary to explore all chromosome inversions.
Vialard
François
F
Departments of reproductive biology, cytogenetics, gynaecology and obstetrics, CHIPS, Poissy, France; INSERM U407, Oullins, France. fvialard@hotmail.com <fvialard@hotmail.com>
Delanete
Audoin
A
Clement
Patrice
P
Simon-Bouy
Brigitte
B
Aubriot
François Xavier
FX
Selva
Jacqueline
J
D000328:Adult; D007446:Chromosome Inversion / Q000235:genetics*; D041321:Chromosomes, Human, X / Q000235:genetics*; D041322:Chromosomes, Human, Y / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D007248:Infertility, Male / Q000235:genetics*; D008297:Male; D012729:Sex Chromosome Aberrations; D013094:Spermatozoa / Q000002:abnormalities* / Q000648:ultrastructure*