title: Sesquiterpenes from Thapsia nitida var. meridionalis and Thapsia nitida var. nitida.
abstract: Nine new eudesmanolides (1-9), two new guaianolides (12 and 13), and a new germacrane (10), along with a previously reported guaianolide (11), have been isolated from the roots of Thapsia nitida var. meridionalis. Thapsia nitida var. nitida also afforded compound 13 along with a new guaianolide (14). The structure of 13 was confirmed by X-ray crystallographic analysis. Compounds 1, 2, and 11-14 have been tested as potential inhibitors of the sarco- and endoplasmic Ca2+-dependent ATPases (SERCA) pump. None of them showed significant activities.
authors.affiliation: Departamento de Química Orgánica, Facultad de Ciencias, Universidad de Cádiz, Apartado 40, 11510 Puerto Real, Cádiz, Spain.
authors.forename: Juan J
authors.initials: JJ
authors.lastname: Rubal
authors.forename: Francisco M
authors.initials: FM
authors.lastname: Guerra
authors.forename: F Javier
authors.initials: FJ
authors.lastname: Moreno-Dorado
authors.forename: Zacarías D
authors.initials: ZD
authors.lastname: Jorge
authors.forename: Guillermo M
authors.initials: GM
authors.lastname: Massanet
authors.forename: Helmer
authors.initials: H
authors.lastname: Søhoel
authors.forename: Ulla W
authors.initials: UW
authors.lastname: Smitt
authors.forename: Karla
authors.initials: K
authors.lastname: Frydenvang
authors.forename: S Brøgger
authors.initials: SB
authors.lastname: Christensen
authors.forename: Charlotte
authors.initials: C
authors.lastname: Nielsen
authors.forename: Margit
authors.initials: M
authors.lastname: Eriksson
mesh_terms: D018360:Crystallography, X-Ray; D008968:Molecular Conformation; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D053498:Sarcoplasmic Reticulum Calcium-Transporting ATPases / Q000037:antagonists & inhibitors*; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013030:Spain; D053629:Thapsia / Q000737:chemistry*
chemical_list: D012717:Sesquiterpenes; D053498:Sarcoplasmic Reticulum Calcium-Transporting ATPases