Occupational acrylonitrile exposure and lung cancer: a meta-analysis.
The present work summarizes the currently available published studies on lung cancer and occupational acrylonitrile exposure. Meta-analytic methods were used to estimate the overall risk. To adjust for the healthy worker effect, rate ratio estimates based on regression analyses and ratios of standard mortality ratios were aggregated. Overall effect estimates were 0.95 (95% CI 0.86 to 1.06) and 1.25 (95% CI 1.10 to 1.43) before and after adjustment for the healthy worker effect, respectively. Therefore, a 25% increase in lung cancer risk attributable to occupational acrylonitrile exposure is suggested. Possible contribution of smoking confounding the increased risk cannot be fully excluded.
Sponsiello-Wang
Zheng
Z
Philip Morris Products SA, Research and Development, Product Risk Management, Quai Jeanrenaud 56, Neuchâtel, Switzerland. zheng.wang@pmintl.com
Sanders
Edward
E
Weitkunat
Rolf
R
D000181:Acrylonitrile / Q000737:chemistry* / Q000633:toxicity*; D002273:Carcinogens / Q000737:chemistry* / Q000633:toxicity*; D006801:Humans; D008175:Lung Neoplasms / Q000139:chemically induced*; D015201:Meta-Analysis as Topic; D016273:Occupational Exposure; D012044:Regression Analysis; D012307:Risk Factors; D015996:Survival Rate
D002273:Carcinogens; D000181:Acrylonitrile