[An analysis of 276 cases of drug-induced liver damage].
OBJECTIVE
Drug-induced liver damage is a potential complication from using many drugs. The aim of our study was to analyze the etiology and clinical features of drug-induced liver damage, in order to draw more attention to this problem.


METHODS
Two hundred and seventy-six cases over a 5-year period in Jiangsu Province Hospital were retrospectively analyzed.


RESULTS
A variety of drugs, including traditional Chinese medicines (26.1% of our total cases) and anticancer drugs (17%) caused liver damage. The main clinical manifestations of it were fatigue, nausea, vomiting and jaundice. In 88% of our cases the symptoms were relieved or completely disappeared, but there was still a 5.1% mortality rate.


CONCLUSIONS
The clinical features of drug-induced liver damage are of no specificity, and the mortality of it is not low. Liver function should be monitored when suspected drugs are prescribed.
Lu
Wei-ting
WT
Department of Infectious Diseases, First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China.
Li
Jun
J
Ou
Ning
N
Chen
Nian
N
Liu
Yuan
Y
Guo
Xue-jiang
XJ
Wang
Rui-yun
RY
Lu
Xiang
X
Huang
Jun
J
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D056487:Chemical and Drug Induced Liver Injury, Chronic / Q000145:classification* / Q000175:diagnosis / Q000209:etiology; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D055815:Young Adult