title: Anisometropic amblyopia treated with spectacle correction alone: possible factors predicting success and time to start patching.
abstract: OBJECTIVE
  To evaluate factors predicting resolution of amblyopia and the time course of improvement in VA in children 3 to 7 years old with anisometropic amblyopia treated with spectacles alone.
  
  
  METHODS
  Prospective, noncomparative intervention.
  
  
  METHODS
  Measurement of corrected amblyopic logMAR visual acuity (VA) in newly diagnosed children at four-weekly intervals until VA stabilized or amblyopia resolved. The time course of improvement in VA and the factors related to amblyopia resolution were assessed.
  
  
  RESULTS
  Sixty children with a mean age of 5.3 years and mean anisometropia of 2.95 diopters (D) were included. Amblyopia improved by 2 or more logMAR lines in 56 patients (93%) and resolved in 27 patients (45%), with a mean improvement in VA of 0.38 logMAR. The improvement in VA in the amblyopic eye was considerable at four to 12 weeks then reached a plateau, after which it improved only slowly. Resolution of amblyopia was related to better initial VA (0.2 to 0.6 logMAR) and lesser amounts of anisometropia (<4 D). The time to resolution ranged from four to 40 weeks, but no patient with residual amblyopia showed an improvement in VA of more than 0.1 logMAR over four consecutive visits.
  
  
  CONCLUSIONS
  With spectacle correction alone, 3- to 7-year-old children with previously untreated anisometropic amblyopia achieved approximately four-line improvement and resolved nearly in half. The nearly two-month plateau periods during improvement of VA should be noticed. After four months with no improvement in VA, occlusion therapy or atropine penalization may be considered.
authors.affiliation: Department of Ophthalmology, Tri-Service General Hospital, #325 Section 2 Cheng-Kung Road, Taipei 114, Taiwan, R.O.C. ddff36@yahoo.com.tw
authors.forename: Po-Liang
authors.initials: PL
authors.lastname: Chen
authors.forename: Jiann-Torng
authors.initials: JT
authors.lastname: Chen
authors.forename: Ming-Cheng
authors.initials: MC
authors.lastname: Tai
authors.forename: Joa-Jing
authors.initials: JJ
authors.lastname: Fu
authors.forename: Cheng-Chunng
authors.initials: CC
authors.lastname: Chang
authors.forename: Da-Wen
authors.initials: DW
authors.lastname: Lu
mesh_terms: D000550:Amblyopia / Q000628:therapy*; D015858:Anisometropia / Q000628:therapy*; D001285:Atropine / Q000008:administration & dosage; D002648:Child; D002675:Child, Preschool; D005139:Eyeglasses; D005260:Female; D006801:Humans; D008297:Male; D011379:Prognosis; D011446:Prospective Studies; D012683:Sensory Deprivation; D013997:Time Factors; D015348:Vision, Binocular / Q000502:physiology; D014792:Visual Acuity / Q000502:physiology*
chemical_list: D001285:Atropine