title: Pre-term pre-labour rupture of membranes: effect of chorioamnionitis on overall neonatal outcome.
abstract: Our objective was to evaluate the association between clinical chorioamnionitis following preterm pre-labour rupture of membranes (PPROM) and adverse neonatal outcome. We compared retrospectively, adverse neonatal outcome of singleton pregnancies with documented PPROM who developed chorioamnionitis (cases) with those who did not (controls). Our result showed that poor neonatal outcome was significantly associated with chorioamnionitis (34% vs 13%; p = 0.008). This association was found on multiple logistic regression analysis to be independent (p < 0.05) of other risk factors for poor neonatal outcome, viz: latency period (p = 0.002) and gestational age at delivery (p < 0.001). We conclude that chorioamnionitis complicating PPROM worsen neonatal outcome. The implication of this on expectant management of PPROM is discussed.
authors.affiliation: Department of Obstetrics and Gynaecology, Ladoke Akintola University of Technology Teaching Hospital, Osogbo, Osun State, Nigeria. oborovo@yahoo.com
authors.forename: V O
authors.initials: VO
authors.lastname: Oboro
authors.forename: B A
authors.initials: BA
authors.lastname: Adekanle
authors.forename: B D
authors.initials: BD
authors.lastname: Apantaku
authors.forename: O A
authors.initials: OA
authors.lastname: Onadipe
mesh_terms: D001034:Apgar Score; D001724:Birth Weight; D002821:Chorioamnionitis; D005260:Female; D005322:Premature Rupture of Fetal Membranes; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000209:etiology*; D008297:Male; D011247:Pregnancy; D011256:Pregnancy Outcome