[Effects of jingui shenqi pill combined prednisone on expression of glucocorticoid receptor and its clinical effect in treating bullous pemphigoid patients].
OBJECTIVE
To investigate the effect of Jingui Shenqi Pill (JSP) on the expression of glucocorticoid receptor (GR) in the skin lesion and its clinical effect in treating bullous pemphigoid (BP) patients.


METHODS
Thirty BP patients were randomly divided into the treatment group (n=15) treated with JSP plus prednisone and the prednisone group (n=15) with prednisone alone both for 4 weeks. And a normal control group was set up also. Expressions of GR-alpha and GR-beta in the skin lesion of BP patients and the normal skin of the normal control were detected by immunohistochemical assay. Results The total effective rate was 93.33% in the treatment group, significantly higher than that in the prednisone group which was 73.33% (P < 0.05); GR-alpha expression was higher in the treatment group than that in other two groups (P < 0.01), while GR-beta expression in the treatment group was lower than that in the prednisone group (P < 0.01).


CONCLUSIONS
JSP could increase GR-alpha expression and decrease GR-beta expression in the skin lesion of BP patients, so as to improve sensitivity of skin to glucocorticoid.
Liu
Bao-guo
BG
The Affiliated Hospital of Hebei Engineering University, Hebei. lbg66@163.com
Li
Zhi-ying
ZY
Du
Ming
M
D000368:Aged; D004359:Drug Therapy, Combination; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D010391:Pemphigoid, Bullous / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D008517:Phytotherapy; D011241:Prednisone / Q000627:therapeutic use*; D011965:Receptors, Glucocorticoid / Q000096:biosynthesis*; D012867:Skin / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D016896:Treatment Outcome
D004365:Drugs, Chinese Herbal; D005938:Glucocorticoids; D011965:Receptors, Glucocorticoid; C510025:jingui shenqi; D011241:Prednisone