[Cytoplasmic K/Na balance in heart muscle cells of young and old rats under oxygen and substrate deficiency].
Age-related changes in the content of the major cellular cations of potassium and sodium in heart muscle cells of Wistar rats have been studied. The cytoplasmic concentration of potassium and sodium was determined by the electron probe microanalysis. The results revealed differences in both the concentration of the elements in young and old control animals and the responses of a cardiomyocyte to the state of acute hypoxic deenergization modelled on a perfused heart. The data are consistent with the hypothesis about the presence of genetically-related age changes in the conductance of potassium channels, which in old animals are realized against the background of deficient supply of tissues with oxygen and substrate.
Pogorelov
A G
AG
Rusakov
A V
AV
Pogorelova
V N
VN
D000375:Aging / Q000378:metabolism*; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002413:Cations, Divalent; D002414:Cations, Monovalent; D015687:Cell Hypoxia; D003593:Cytoplasm / Q000378:metabolism*; D005947:Glucose / Q000172:deficiency*; D066298:In Vitro Techniques; D007773:Lactates / Q000378:metabolism; D008297:Male; D009206:Myocardium / Q000378:metabolism; D032383:Myocytes, Cardiac / Q000378:metabolism*; D010477:Perfusion; D051381:Rats; D017208:Rats, Wistar; D012964:Sodium / Q000378:metabolism*
D002413:Cations, Divalent; D002414:Cations, Monovalent; D007773:Lactates; D012964:Sodium; D005947:Glucose; D002118:Calcium