Inherited aspects of papillary thyroid carcinoma.
The presence of papillary carcinoma of the thyroid in multiple generations of one kindred is a statistical impossibility as an occurrence of chance. However, traditional and molecular genetic analyses to date have failed to support the notion of a single gene mutation or identify one, in distinct contrast to medullary carcinoma of the thyroid. Findings to date, outside of distinct multicancer syndromes, suggest the interplay of inherited susceptibility and other factors, such as environmental exposures. It is possible that the main identifiable genetic risk factors at this time are the presence of multinodular goiter or Hashimoto's thyroiditis within the family.
Moore
Francis D
FD
Brigham and Women's Hospital, 75 Francis Street, Boston, MA, USA. fmoore@partners.org
D018263:Adenocarcinoma, Follicular / Q000235:genetics; D011125:Adenomatous Polyposis Coli / Q000235:genetics; D002291:Carcinoma, Papillary / Q000235:genetics*; D064447:Checkpoint Kinase 2; D016147:Genes, Tumor Suppressor; D006223:Hamartoma Syndrome, Multiple / Q000235:genetics; D006801:Humans; D009154:Mutation; D024862:Oxyphil Cells / Q000473:pathology; D017346:Protein Serine-Threonine Kinases / Q000235:genetics; D051096:Proto-Oncogene Proteins c-ret / Q000235:genetics; D012307:Risk Factors; D013964:Thyroid Neoplasms / Q000235:genetics*; D013967:Thyroiditis, Autoimmune / Q000235:genetics
D064447:Checkpoint Kinase 2; D051096:Proto-Oncogene Proteins c-ret; C099282:RET protein, human; C578634:CHEK2 protein, human; D017346:Protein Serine-Threonine Kinases