title: Episodes of Guillain-Barré syndrome associated with the acute phase of HIV-1 infection and with recurrence of viremia.
abstract: We report a severe case of Guillain-Barré syndrome (GBS) characterized by flaccid areflexive tetraplegia and signs of autonomic instability related to acute HIV-1 infection, and the occurrence of relapse episodes coinciding with the detection of HIV-1 RNA in blood during the phase of irregular treatment with antiretroviral agents. The patient has been asymptomatic for 3 years and has an HIV-1 load below the limit of detection. The recurrence of GBS in this case may be related to alterations of the immunologic response caused by disequilibrium in the host-HIV relationship due to the increase in HIV-1 viremia.
authors.affiliation: Faculty of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil. gcastro@hcrp.fmrp.usp.br
authors.forename: Gleusa
authors.initials: G
authors.lastname: de Castro
authors.forename: Patrícia Gomes
authors.initials: PG
authors.lastname: Bastos
authors.forename: Roberto
authors.initials: R
authors.lastname: Martinez
authors.forename: José Fernando
authors.initials: JF
authors.lastname: de Castro Figueiredo
mesh_terms: D000208:Acute Disease; D000328:Adult; D020275:Guillain-Barre Syndrome / Q000175:diagnosis / Q000628:therapy / Q000821:virology*; D015658:HIV Infections / Q000150:complications*; D015497:HIV-1; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage*; D008297:Male; D012008:Recurrence; D012720:Severity of Illness Index; D019562:Viral Load; D014766:Viremia / Q000150:complications*
chemical_list: D016756:Immunoglobulins, Intravenous