title: Docetaxel labeled with iodine 131 radionuclide--a possible new anticancer drug? (The pilot study).
abstract: The cytotoxic potentials of the lipiodol emulsion with dissolved 131I-docetaxel, the 131I-lipiodol emulsion and non-labeled docetaxel were tested on the HeLa Hep2 cell line during 24 hours. The pilot study confirmed that the radio-labeled docetaxel was significantly more toxic than the radionuclide or docetaxel alone.
authors.affiliation: Institute of Experimental Biopharmaceutics, Joint Research Center of Czech Academy of Sciences and PRO.MED.CS, Hradec Králové, Czech Republic. pastera@uebf.cas.cz
authors.forename: Jirí
authors.initials: J
authors.lastname: Pastera
authors.forename: Emil
authors.initials: E
authors.lastname: Rudolf
authors.forename: Milan
authors.initials: M
authors.lastname: Dittrich
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects*; D000077143:Docetaxel; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D006801:Humans; D007457:Iodine Radioisotopes / Q000494:pharmacology*; D007459:Iodized Oil / Q000494:pharmacology; D010865:Pilot Projects; D011838:Radiation-Sensitizing Agents / Q000494:pharmacology*; D043823:Taxoids / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D007457:Iodine Radioisotopes; D011838:Radiation-Sensitizing Agents; D043823:Taxoids; D000077143:Docetaxel; D007459:Iodized Oil