Dietary intake of B-vitamins, polymorphisms in thymidylate synthase and serine hydroxymethyltransferase 1, and colorectal adenoma risk: a Dutch case-control study.
Thymidylate synthase and serine hydroxymethyltransferase are involved in folate metabolism. In a case-control study, including 768 cases and 709 controls, we investigated the associations between colorectal adenomas and TS tandem repeat and SHMT1 C1420T polymorphisms, and the interplay with B-vitamins. The polymorphisms were not associated with adenomas, but there was a borderline significant interaction between TS genotype and vitamin B6: the association between vitamin B6 and adenomas seemed positive in TS 3R/3R individuals, but inverse in TS 2R/2R individuals. This study does not provide evidence for a role of SHMT1 genotype in adenoma occurrence. Future research has to indicate whether the TS-B6 interplay is a real effect or a chance finding.
van den Donk
Maureen
M
Division of Human Nutrition, Wageningen University, P.O. Box 8129, NL-6700 EV Wageningen, The Netherlands.
Visker
Marleen H P W
MH
Harryvan
Jan L
JL
Kok
Frans J
FJ
Kampman
Ellen
E
D000236:Adenoma / Q000235:genetics*; D000368:Aged; D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000235:genetics*; D004032:Diet; D005492:Folic Acid; D012696:Glycine Hydroxymethyltransferase / Q000235:genetics*; D006801:Humans; D008875:Middle Aged; D009426:Netherlands; D011110:Polymorphism, Genetic; D012256:Riboflavin; D012307:Risk Factors; D013940:Thymidylate Synthase / Q000235:genetics*; D014805:Vitamin B 12; D025101:Vitamin B 6; D014803:Vitamin B Complex
D014803:Vitamin B Complex; D025101:Vitamin B 6; D005492:Folic Acid; D013940:Thymidylate Synthase; D012696:Glycine Hydroxymethyltransferase; C520541:SHMT protein, human; D014805:Vitamin B 12; D012256:Riboflavin