title: High-dose ziprasidone-induced acute dystonia.
abstract: There are few clinical data describing the relative risks of extrapyramidal symptoms (EPS) at higher doses of ziprasidone (i.e., greater than 160 mg/day) when compared to lower doses. We report on a patient who displayed no EPS with ziprasidone 160 mg/day for several months, but did display marked, acute dystonic reactions on ziprasidone 240 mg/day. The observations from the present case indicate that high-dose, ziprasidone-induced acute dystonia may occur even if no such side effects have been experienced at doses up to and including 160 mg/day.
authors.affiliation: Department of Psychiatry, College of Physicians and Surgeons, Columbia University, and New York State Psychiatric Institute, 1051 Riverside Drive, Box 109, New York, NY 10032, USA.
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Rosenfield
authors.forename: Ragy R
authors.initials: RR
authors.lastname: Girgis
authors.forename: Roberto
authors.initials: R
authors.lastname: Gil
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D004421:Dystonia / Q000139:chemically induced*; D005260:Female; D006801:Humans; D010879:Piperazines / Q000009:adverse effects*; D012559:Schizophrenia / Q000188:drug therapy; D013844:Thiazoles / Q000009:adverse effects*
chemical_list: D014150:Antipsychotic Agents; D010879:Piperazines; D013844:Thiazoles; C092292:ziprasidone