title: Molecular simulation of protein aggregation.
abstract: Computer simulation offers unique possibilities for investigating molecular-level phenomena difficult to probe experimentally. Drawing from a wealth of studies concerning protein folding, computational studies of protein aggregation are emerging. These studies have been successful in capturing aspects of aggregation known from experiment and are being used to refine experimental methods aimed at abating aggregation. Here we review molecular-simulation studies of protein aggregation conducted in our laboratory. Specific attention is devoted to issues with implications for biotechnology.
authors.affiliation: Department of Chemistry, Virginia Commonwealth University, Richmond, VA 23284, USA.
authors.forename: Dusan
authors.initials: D
authors.lastname: Bratko
authors.forename: Troy
authors.initials: T
authors.lastname: Cellmer
authors.forename: John M
authors.initials: JM
authors.lastname: Prausnitz
authors.forename: Harvey W
authors.initials: HW
authors.lastname: Blanch
mesh_terms: D001665:Binding Sites; D003198:Computer Simulation; D019281:Dimerization; D046912:Multiprotein Complexes / Q000737:chemistry* / Q000648:ultrastructure*; D011485:Protein Binding; D011487:Protein Conformation; D017510:Protein Folding; D011506:Proteins / Q000737:chemistry* / Q000648:ultrastructure*; D020539:Sequence Analysis, Protein / Q000379:methods*
chemical_list: D046912:Multiprotein Complexes; D011506:Proteins