title: An analysis of surgical complications, morbidity, and cost calculation in patients undergoing multimodal treatment for operable oropharyngeal carcinoma.
abstract: OBJECTIVE
  Tumor control and survival are considered the most important measures of treatment efficacy for patients with primary oropharyngeal squamous cell carcinoma. Furthermore, multimodal treatment protocols should be judged by their complication rates, morbidity, and therapy costs.
  
  
  METHODS
  The results of a combined approach of primary surgery and neck dissection with postoperative radio(chemo)therapy were analyzed in retrospective chart review.
  
  
  METHODS
  Two hundred eleven patients' records were analyzed for surgical complications, therapeutic morbidity, and treatment costs.
  
  
  RESULTS
  The rate of postoperative hemorrhage was 4.7%. We observed no fatal complications. Ten percent of our patients required nutrition through percutaneous endoscopic gastrostomy (PEG). Twelve percent of all patients required long-term tracheostomy. The rates of PEG and tracheostomy were significantly higher in patients operated by the transcervical approach. The costs for the combined approach ranged from 10,587 euros (13,377 dollars) to 24,531 euros (30,996 dollars).
  
  
  CONCLUSIONS
  The presented multimodal approach provides a low rate of surgical complications and a tolerable morbidity. Considering the excellent oncologic results, this extensive and more cost-intensive multimodal approach is justified for patients with oropharyngeal cancer.
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, School of Medicine, University of Cologne, Cologne, Germany. simon.preuss@uni-koeln.de
authors.forename: Simon F
authors.initials: SF
authors.lastname: Preuss
authors.forename: Gero
authors.initials: G
authors.lastname: Quante
authors.forename: Robert
authors.initials: R
authors.lastname: Semrau
authors.forename: Rolf-Peter
authors.initials: RP
authors.lastname: Mueller
authors.forename: Jens Peter
authors.initials: JP
authors.lastname: Klussmann
authors.forename: Orlando
authors.initials: O
authors.lastname: Guntinas-Lichius
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000191:economics / Q000628:therapy*; D003131:Combined Modality Therapy / Q000009:adverse effects / Q000191:economics; D004180:Direct Service Costs; D005260:Female; D005774:Gastrostomy / Q000706:statistics & numerical data; D006801:Humans; D008297:Male; D008875:Middle Aged; D037981:Neck Dissection / Q000191:economics; D009959:Oropharyngeal Neoplasms / Q000191:economics / Q000628:therapy*; D011183:Postoperative Complications / Q000453:epidemiology; D012189:Retrospective Studies; D014139:Tracheostomy / Q000706:statistics & numerical data; D016896:Treatment Outcome