Prediction of thrombolytic efficacy in acute ischemic stroke using thin-section noncontrast CT.
Thin-section noncontrast CT (NCT) can detect thrombi in large arteries and can provide a measure of thrombus composition based on Hounsfield Units (HU). A study using polyethylene tubes as a model of intracranial arteries concluded that the HUs of platelet-rich thrombi are lower than those of erythrocyte-rich thrombi. Thrombus HUs were measured by NCT in 34 patients with acute ischemic stroke before thrombolysis. Thrombi with lower HU counts were resistant to thrombolytics.
Kim
E Y
EY
Department of Radiology and Research Institute of Radiological Sciences, Yonsei University College of Medicine, 134 Shinchon-dong, Seodaemun-gu, Seoul 120-752, Korea. eungykim@yumc.yonsei.ac.kr
Heo
J H
JH
Lee
S-K
SK
Kim
D J
DJ
Suh
S-H
SH
Kim
J
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Kim
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D000368:Aged; D000369:Aged, 80 and over; D001792:Blood Platelets / Q000000981:diagnostic imaging / Q000473:pathology; D002545:Brain Ischemia / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000503:physiopathology; D002536:Cerebral Arteries / Q000000981:diagnostic imaging* / Q000187:drug effects / Q000503:physiopathology; D004351:Drug Resistance / Q000502:physiology; D004912:Erythrocytes / Q000000981:diagnostic imaging / Q000473:pathology; D005260:Female; D005343:Fibrinolytic Agents / Q000009:adverse effects / Q000494:pharmacology*; D006801:Humans; D020767:Intracranial Thrombosis / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D018579:Patient Selection; D020959:Polyethylene; D011237:Predictive Value of Tests; D011300:Preoperative Care; D020521:Stroke / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000503:physiopathology; D010959:Tissue Plasminogen Activator / Q000009:adverse effects / Q000494:pharmacology; D014057:Tomography, X-Ray Computed / Q000379:methods* / Q000592:standards / Q000639:trends; D016896:Treatment Outcome
D005343:Fibrinolytic Agents; D020959:Polyethylene; D010959:Tissue Plasminogen Activator