Hepatocytes detoxify Atuna racemosa extract.
A number of traditional medicine plants are hepatotoxic. Thus, while the traditional uses of Atuna racemosa suggest little indication for toxicity, it is nonetheless important to examine the potential for this extract to target the liver. Using Jurkat T cells and HepG2 hepatocytes as a model, the potential hepatotoxicity of this extract was evaluated. The results of a conditioned media experiment suggest that A. racemosa extract would likely be detoxified by the liver. These results provide the necessary background to initiate an in vivo toxicology investigation.
Buenz
Eric J
EJ
Complementary and Integrative Medicine Program, Mayo Clinic College of Medicine, Rochester, MN 55905, USA. buenz@biosciential.com
D002453:Cell Cycle / Q000187:drug effects; D016923:Cell Death / Q000187:drug effects*; D017077:Culture Media, Conditioned; D005434:Flow Cytometry; D022781:Hepatocytes / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D008658:Inactivation, Metabolic; D019169:Jurkat Cells; D010936:Plant Extracts / Q000633:toxicity*; D027824:Rosaceae
D017077:Culture Media, Conditioned; D010936:Plant Extracts