[Preparation and characterization of a new injectable bone substitute-carrageenan/nano-hydroxyapatite/collagen].
OBJECTIVE
To develop a new injectable biomaterial carrageenan/nano-hydroxyapatite/collagen (nHAC/Carr) for bone surgery and characterize it.


METHODS
nHAC/Carr was developed by filling carrageenan with nano-hydroxyapatite/collagen (nHAC) granules.


RESULTS
It was found that nHAC/Carr had similar X-ray diffraction patterns with that of nHAC. Fourier transform infrared spectroscopy showed that carrageenan did not change its structure in nHAC/Carr. The rheological behavior of nHAC/Carr was the same as carrageenan. The scanning electron microscopy and porosity analysis showed that nHAC/Carr had porous structure and its porosity was about 90%.


CONCLUSIONS
The biomaterial nHAC/Carr may be used as an injectable bone substitute.
Gan
Shao-lei
SL
Department of Material Science and Engineering, Tsinghua University, Beijing 100084, China.
Feng
Qing-ling
QL
D018786:Bone Substitutes / Q000737:chemistry; D002351:Carrageenan; D003094:Collagen; D017886:Durapatite; D007267:Injections; D008855:Microscopy, Electron, Scanning; D053758:Nanoparticles; D016062:Porosity; D013499:Surface Properties; D014961:X-Ray Diffraction
D018786:Bone Substitutes; D002351:Carrageenan; D003094:Collagen; D017886:Durapatite