title: [Photodynamic therapy with visudyne in treatment of wet form of age-related macular degeneration--two years results].
abstract: BACKGROUND
  Photodynamic therapy with Visudyne represents a new method in treatment of the wet form of age-related macular degeneration.
  
  
  RESULTS
  Effectiveness of photodynamic therapy with Visudyne was confirmed at our department in the group of 49 patients (13 men, 36 women) of mean age 72.7 years with predominantly classical and occult choroidal neovascular membrane in subfoveal localization in wet form of age-related macular degeneration. The observation period in all patients in this group was 24 month. During the observation period, 27 patients with predominantly classical choroidal neovascular membrane underwent 1 to 5 treatments (mean 1.8). Before the treatment the average best corrected visual acuity was 0.696 +/- 0.20 logMAR. At the end of observation period the average best corrected visual acuity was 0.985 +/- 0.39 logMAR. Best corrected visual acuity dropped by 2.88 lines of ETDRS (early treatment diabetic retinopathy study) visual charts. 22 patients with the genuine occult choroidal neovascular membrane underwent during the observation period 1 to 3 treatments (mean 1.5). Average best corrected visual acuity before the treatment was 0.755 +/- 0.25 logMAR. At the end of observation period the average best corrected visual acuity was 0.909 +/- 0.42 logMAR. We found out the decrease of average best corrected visual acuity by 1.55 lines of ETDRS charts.
  
  
  CONCLUSIONS
  Decrease of the average best corrected visual acuity less than 3 lines at ETDRS charts is considered as stabilisation of the finding. In our group this goal was achieved in 2/3 of patients.
authors.affiliation: Oftalmologicá klinika LF MU a FN, Brno. pkolar@fnbrno.cz
authors.forename: P
authors.initials: P
authors.lastname: Kolár
authors.forename: D
authors.initials: D
authors.lastname: Vizdová
authors.forename: E
authors.initials: E
authors.lastname: Vlková
mesh_terms: D000368:Aged; D020256:Choroidal Neovascularization / Q000150:complications / Q000188:drug therapy; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D008268:Macular Degeneration / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D008297:Male; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000627:therapeutic use*; D011166:Porphyrins / Q000627:therapeutic use*; D000077362:Verteporfin
chemical_list: D017319:Photosensitizing Agents; D011166:Porphyrins; D000077362:Verteporfin