Anti-p53 antibodies in patients with dermatomyositis/polymyositis.
Dermatomyositis/polymyositis (DM/PM), which is often accompanied by various immunological abnormalities, was reported to be associated with an increased incidence of malignancies. In this study, we analyzed serum levels of anti-p53 antibody (anti-p53 Ab) in DM/PM patients and in normal controls. Serum levels of anti-p53 Abs were significantly higher in DM/PM patients than those in healthy controls. However, there was no significant difference between serum levels in patients with malignancies and those in patients without malignancies. Anti-p53 Abs were positive in 13% (4 out of 31) of the DM/PM patients. Of these four patients, only one had an internal malignancy. Immunoglobulin G levels were significantly higher in patients positive for anti-p53 Ab than those who were not. These results seemed to suggest that the presence of anti-p53 Abs in DM/PM patients is due to immunological abnormalities in this disease.
Mimura
Yoshihiro
Y
Department of Dermatology, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
Yazawa
Norihito
N
Tamaki
Zenshirou
Z
Ashida
Ryuichi
R
Jinnin
Masatoshi
M
Asano
Yoshihide
Y
Tada
Yayoi
Y
Kubo
Masahide
M
Ihn
Hironobu
H
Tamaki
Kunihiko
K
D000328:Adult; D001323:Autoantibodies / Q000097:blood*; D016022:Case-Control Studies; D003882:Dermatomyositis / Q000097:blood* / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016159:Tumor Suppressor Protein p53 / Q000097:blood / Q000276:immunology*
D001323:Autoantibodies; D016159:Tumor Suppressor Protein p53