title: In vivo sampling with solid phase microextraction.
abstract: This review discusses the most recent developments and future challenges in the application of solid phase microextraction (SPME) for sampling of live biological samples. The emphasis is placed on applications of fiber SPME for analysis of volatile emissions and drugs in biological fluids. The method development section highlights the main parameters that need to be considered in the case of in vivo experiments: extraction techniques, selection of extraction phases, calibration procedures, determination of free concentrations, and automation.
authors.affiliation: Department of Chemistry, University of Waterloo, Waterloo, Ontario, Canada.
authors.forename: Florin Marcel
authors.initials: FM
authors.lastname: Musteata
authors.forename: Janusz
authors.initials: J
authors.lastname: Pawliszyn
mesh_terms: D004353:Drug Evaluation, Preclinical / Q000379:methods*; D006801:Humans; D009930:Organic Chemicals / Q000032:analysis*; D012867:Skin / Q000378:metabolism*; D052616:Solid Phase Extraction / Q000379:methods*; D013048:Specimen Handling / Q000379:methods*; D014835:Volatilization
chemical_list: D009930:Organic Chemicals