title: Axon guidance: ephrins at WRK on the midline.
abstract: Recent findings indicate that the embryonic motor neurons act as gatekeepers to regulate midline crossing during development of the nematode Caenorhabditis elegans. The newly identified protein WRK-1 and ephrins cooperate to prevent longitudinal axons from crossing the midline.
authors.affiliation: UMDNJ-Robert Wood Johnson Medical School, Department of Pathology, 675 Hoes Lane, Piscataway, New Jersey 08854-5635, USA. quinncc@umdnj.edu
authors.forename: Christopher C
authors.initials: CC
authors.lastname: Quinn
authors.forename: William G
authors.initials: WG
authors.lastname: Wadsworth
mesh_terms: D000818:Animals; D001369:Axons / Q000378:metabolism / Q000502:physiology*; D017173:Caenorhabditis elegans / Q000196:embryology*; D029742:Caenorhabditis elegans Proteins / Q000378:metabolism*; D036342:Ephrins / Q000378:metabolism*; D009046:Motor Neurons / Q000378:metabolism / Q000502:physiology*; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D009420:Nervous System / Q000196:embryology*; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D029742:Caenorhabditis elegans Proteins; D036342:Ephrins; D009419:Nerve Tissue Proteins; C515032:WRK-1 protein, C elegans