title: Antimicrobial prophylaxis to prevent surgical site infections in a rural sub-Saharan hospital.
abstract: A prospective cohort study was performed to collect baseline data concerning surgical site infections (SSIs) and antimicrobial prophylaxis (AMP) in a remote sub-Saharan district hospital. The SSI rate of 22% was high. Most (88%) of the patients received prophylaxis after incision, and only 5% within the 30-min period before incision. Of all pathogens isolated from SSIs, 60% were resistant to the agent administered. The antibiotics given most frequently were chloramphenicol (60%), aminopenicillins (23%) and benzylpenicillin (15%). Staphylococcus aureus (36%), Escherichia coli (5%) and enterococci (4%) were the pathogens isolated most commonly from SSIs.
authors.affiliation: Department of Medicine and Diagnostics, Swiss Tropical Institute, Basel, Switzerland.
authors.forename: J
authors.initials: J
authors.lastname: Fehr
authors.forename: C
authors.initials: C
authors.lastname: Hatz
authors.forename: I
authors.initials: I
authors.lastname: Soka
authors.forename: P
authors.initials: P
authors.lastname: Kibatala
authors.forename: H
authors.initials: H
authors.lastname: Urassa
authors.forename: M
authors.initials: M
authors.lastname: Battegay
authors.forename: Z
authors.initials: Z
authors.lastname: Jeffrey
authors.forename: T
authors.initials: T
authors.lastname: Smith
authors.forename: H
authors.initials: H
authors.lastname: Mshinda
authors.forename: R
authors.initials: R
authors.lastname: Frei
authors.forename: A F
authors.initials: AF
authors.lastname: Widmer
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D019072:Antibiotic Prophylaxis; D001419:Bacteria / Q000187:drug effects / Q000302:isolation & purification*; D015331:Cohort Studies; D024881:Drug Resistance, Bacterial; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D019035:Rural Health Services / Q000706:statistics & numerical data; D013530:Surgical Wound Infection / Q000382:microbiology* / Q000517:prevention & control*; D013636:Tanzania
chemical_list: D000900:Anti-Bacterial Agents