title: C35 terpenoids from the bark of Calocedrus macrolepis var. formosana with activity against human cancer cell lines.
abstract: Ferrugicadinol (1) and ferrugieudesmol (2), two new compounds with a unique C35 terpene skeleton, were isolated from the bark of Calocedrus macrolepis var. formosana. Their structures were elucidated principally from spectroscopic evidence. The two new C35 terpenes showed cytotoxicity against human oral epidermoid carcinoma KB cells with IC50 values ranging from 11 to 14 microM.
authors.affiliation: Department of Chemistry, National Taiwan University, Taipei, Taiwan 106.
authors.forename: Chin-Lin
authors.initials: CL
authors.lastname: Hsieh
authors.forename: Mei-Huims
authors.initials: MH
authors.lastname: Tseng
authors.forename: Yi-Yuan
authors.initials: YY
authors.lastname: Shao
authors.forename: Jang-Yang
authors.initials: JY
authors.lastname: Chang
authors.forename: Ching-Chuan
authors.initials: CC
authors.lastname: Kuo
authors.forename: Chi-Yen
authors.initials: CY
authors.lastname: Chang
authors.forename: Yueh-Hsiung
authors.initials: YH
authors.lastname: Kuo
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor; D029779:Cupressaceae / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020128:Inhibitory Concentration 50; D007624:KB Cells; D024301:Plant Bark / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D013624:Taiwan; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D013729:Terpenes; C516751:ferrugicadinol; C516752:ferrugieudesmol