DNA repair: corrections in the golden years.
Genetic changes increase with the age of organisms, but the basis for this increase is unclear. A study has found that the major pathway of DNA repair is altered with age in the testes of male Drosophila, thus providing a powerful system to dissect the basis for age-related genomic changes.
Gottschling
Daniel E
DE
Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA. dgottsch@fhcrc.org
D000375:Aging / Q000502:physiology*; D000818:Animals; D053903:DNA Breaks, Double-Stranded; D004260:DNA Repair / Q000502:physiology*; D015252:Deoxyribonucleases, Type II Site-Specific / Q000378:metabolism*; D004330:Drosophila / Q000235:genetics / Q000502:physiology*; D008297:Male; D029701:Saccharomyces cerevisiae Proteins; D013094:Spermatozoa / Q000737:chemistry*
D029701:Saccharomyces cerevisiae Proteins; C037725:SCEI protein, S cerevisiae; D015252:Deoxyribonucleases, Type II Site-Specific