title: IMBA Professional Plus: a flexible approach to internal dosimetry.
abstract: IMBA (Integrated Modules for Bioassay Analysis) is a suite of software modules that implement the current ICRP biokinetic and dosimetric models for estimation of intakes and doses. The IMBA modules have gone through extensive quality assurance, and are now used for routine formal dose assessment by Approved Dosimetry Services throughout the UK. HPA has continued to develop the IMBA modules. In addition, several projects, sponsored by organisations both in the USA and in Canada, have resulted in the development of customised user-friendly interfaces (IMBA Expert 'editions'). These enable users not only to use the standard ICRP models, but also to change many of the parameter values from ICRP defaults, and to apply sophisticated data handling techniques to internal dose calculations. These include: fitting measurement data with the maximum likelihood method; using multiple chronic and acute intakes; and dealing with different data types, such as urine, faces and whole body simultaneously. These interfaces were improved further as a result of user-feedback, and a general 'off-the-shelf' product, IMBA Professional, was developed and made available in January 2004. A new version, IMBA Professional Plus, was released in April 2005, which is both faster and more powerful than previous software. The aim of this paper is to describe the capabilities of IMBA Professional Plus, and the mathematical methods used.
authors.affiliation: Radiation Protection Division, Health Protection Agency, Chilton, Didcot, Oxon. OX11 0RQ, UK. alan.birchall@hpa.org.uk
authors.forename: A
authors.initials: A
authors.lastname: Birchall
authors.forename: M
authors.initials: M
authors.lastname: Puncher
authors.forename: J W
authors.initials: JW
authors.lastname: Marsh
authors.forename: K
authors.initials: K
authors.lastname: Davis
authors.forename: M R
authors.initials: MR
authors.lastname: Bailey
authors.forename: N S
authors.initials: NS
authors.lastname: Jarvis
authors.forename: A D
authors.initials: AD
authors.lastname: Peach
authors.forename: M-D
authors.initials: MD
authors.lastname: Dorrian
authors.forename: A C
authors.initials: AC
authors.lastname: James
mesh_terms: D000465:Algorithms; D001681:Biological Assay / Q000379:methods*; D001822:Body Burden; D003198:Computer Simulation; D006801:Humans; D038622:Internationality; D008954:Models, Biological; D011834:Radiation Monitoring / Q000379:methods*; D011835:Radiation Protection / Q000379:methods*; D012062:Relative Biological Effectiveness; D015203:Reproducibility of Results; D018570:Risk Assessment / Q000379:methods; D012680:Sensitivity and Specificity; D012984:Software; D012985:Software Design; D014584:User-Computer Interface