Targeting lipoxygenases with care.
Though fish oils possess cardio-protective, anti-inflammatory, and anti-cancer properties, their molecular and biochemical mechanism of action is lacking. In this issue of Chemistry & Biology, Tjonahen and colleagues identify a new metabolite of eicosapentanoic acid, resolvin E2, produced by 5-lipoxygenase.
de Souza
Patricia M
PM
Airway Disease Section, National Heart & Lung Institute, Imperial College of Medicine, Dovehouse Street, London, SW3 6LY, United Kingdom.
Newson
Justine
J
Gilroy
Derek W
DW
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000378:metabolism* / Q000494:pharmacology; D001094:Arachidonate 5-Lipoxygenase / Q000378:metabolism*; D015118:Eicosapentaenoic Acid / Q000031:analogs & derivatives* / Q000096:biosynthesis / Q000378:metabolism / Q000494:pharmacology; D006801:Humans; D009504:Neutrophils / Q000187:drug effects / Q000276:immunology / Q000378:metabolism; D010538:Peritonitis / Q000188:drug therapy / Q000276:immunology
D000893:Anti-Inflammatory Agents; C517406:resolvin E2; D015118:Eicosapentaenoic Acid; D001094:Arachidonate 5-Lipoxygenase; C499823:5S,12R,18R-trihydroxy-6Z,8E,10E,14Z,16E-eicosapentaenoic acid