[Intestinal leishmaniasis and Sézary syndrome: endoscopic diagnosis].
Sézary syndrome is a non-Hodgkin's lymphoma of cutaneous origin that provokes severe cellular immunosuppression leading to greater susceptibility to opportunistic infections. We present the case of a male patient with a diagnosis of Sézary syndrome complicated by visceral leishmaniasis and Mycobacterium avium complex coinfection, with intestinal involvement of both pathogens -an exceptional finding in the absence of HIV infection. The diagnosis was confirmed by bone marrow biopsy and oral endoscopy with intestinal biopsy. Because of the severity of the infection and the failure of conventional treatment, miltefosine, a new antiparasitic agent still under investigation, was administered with favorable response. However the patient developed fatal pneumonia.
Masedo González
Angeles
A
Servicio de Medicina del Aparato Digestivo. Hospital Universitario 12 de Octubre. Madrid. España. amasedo@yahoo.es
Barbero Allende
José María
JM
Pérez-Carreras
Mercedes
M
Garrido
María
M
Lizasoain
Manuel
M
Solís Herruzo
José Antonio
JA
D000328:Adult; D001706:Biopsy; D004386:Duodenum / Q000473:pathology; D016099:Endoscopy, Gastrointestinal; D017809:Fatal Outcome; D006801:Humans; D007410:Intestinal Diseases / Q000150:complications* / Q000175:diagnosis*; D007898:Leishmaniasis, Visceral / Q000150:complications* / Q000175:diagnosis*; D008297:Male; D015270:Mycobacterium avium-intracellulare Infection / Q000150:complications / Q000175:diagnosis; D009894:Opportunistic Infections / Q000150:complications* / Q000175:diagnosis*; D012751:Sezary Syndrome / Q000150:complications*