title: [Preclinical diagnosis of cardiovascular diseases in workers engaged into industries with radiation danger].
abstract: The authors presented results of single-stage cross study of randomized select from a cohort of long seniority workers of isotope separation plant in Siberian Chemical Enterprise, with studies of inflammation markers, vascular and platelet hemostasis, serum lipid parameters, calculated atherogeneity coefficient, homocysteine levels. Serum atherogeneity coefficient and inflammation markers levels (fibrinogen, C-reactive protein) could be considered as the most informative laboratory indicators of underlying cardiovascular diseases in individuals without ischemic heart disease. Among a list of standard inductors of platelet aggregation, collagen and epinephrine should be considered preferential. Increased platelet aggregation requires disaggregant therapy, especially in smokers. Increased homocysteine level is associated with high frequency of atherosclerotic plaques and smoking.
authors.forename: R M
authors.initials: RM
authors.lastname: Takhauov
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Semënova
authors.forename: A B
authors.initials: AB
authors.lastname: Karpov
authors.forename: I I
authors.initials: II
authors.lastname: Kubat
authors.forename: E Iu
authors.initials: EIu
authors.lastname: Kretova
authors.forename: T M
authors.initials: TM
authors.lastname: Litvinenko
authors.forename: I A
authors.initials: IA
authors.lastname: Baranova
authors.forename: E Iu
authors.initials: EIu
authors.lastname: Zhivova
authors.forename: S V
authors.initials: SV
authors.lastname: Popov
mesh_terms: D000328:Adult; D000465:Algorithms; D002097:C-Reactive Protein / Q000032:analysis; D002318:Cardiovascular Diseases / Q000097:blood / Q000175:diagnosis* / Q000209:etiology; D002617:Chemical Industry; D016009:Chi-Square Distribution; D015331:Cohort Studies; D003627:Data Interpretation, Statistical; D006710:Homocysteine / Q000097:blood; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D009784:Occupational Diseases / Q000097:blood / Q000175:diagnosis* / Q000209:etiology; D016273:Occupational Exposure / Q000009:adverse effects*; D010974:Platelet Aggregation; D011830:Radiation Effects; D012307:Risk Factors; D012800:Siberia; D012907:Smoking / Q000009:adverse effects; D013997:Time Factors
chemical_list: D008055:Lipids; D006710:Homocysteine; D002097:C-Reactive Protein