title: Mono- and dihydroxylated metabolites of thalidomide: synthesis and TNF-alpha production-inhibitory activity.
abstract: Mono- and dihydroxylated metabolites of thalidomide were efficiently prepared and characterized, and their inhibitory activity on tumor necrosis factor (TNF)-alpha production in the human monocytic leukemia cell line THP-1 was evaluated. 5,N-Dihydroxythalidomide was a much more potent TNF-alpha production inhibitor than thalidomide.
authors.affiliation: Institute of Molecular and Cellular Biosciences, The University of Tokyo.
authors.forename: Takanori
authors.initials: T
authors.lastname: Nakamura
authors.forename: Tomomi
authors.initials: T
authors.lastname: Noguchi
authors.forename: Hisayoshi
authors.initials: H
authors.lastname: Kobayashi
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Miyachi
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Hashimoto
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000494:pharmacology; D045744:Cell Line, Tumor; D006801:Humans; D015394:Molecular Structure; D013792:Thalidomide / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors*
chemical_list: C516816:5,N-dihydroxythalidomide; D000970:Antineoplastic Agents; D014409:Tumor Necrosis Factor-alpha; D013792:Thalidomide