title: In vivo tetracycline labeling of bone: an intraoperative aid in the surgical therapy of osteoradionecrosis of the mandible.
abstract: In this technical approach, we demonstrate that preoperative tetracycline administration helps distinguish between viable and necrotic bone in osteoradionecrosis (ORN) during surgery by exciting tetracycline fluorescence by black light. The difficult aspect of the operative approach lies in the decision of the extent of the debridement in order to prevent an iatrogenic fracture or progression of ORN. With this technique, vital bone, in contrast to necrotic bone, showed detectable fluorescence. Therefore, tetracycline fluorescence labeling may be used in attempts to facilitate the intraoperative decision making in the surgical therapy of osteoradionecrosis.
authors.affiliation: Department of Oral and Craniomaxillofacial Surgery, Technical University of Munich, Munich, Germany. christoph.pautke@gmx.net <christoph.pautke@gmx.net>
authors.forename: Christoph
authors.initials: C
authors.lastname: Pautke
authors.forename: Thomas
authors.initials: T
authors.lastname: Tischer
authors.forename: Andreas
authors.initials: A
authors.lastname: Neff
authors.forename: Hans-Henning
authors.initials: HH
authors.lastname: Horch
authors.forename: Andreas
authors.initials: A
authors.lastname: Kolk
mesh_terms: D016371:Cranial Irradiation / Q000009:adverse effects; D005456:Fluorescent Dyes; D006801:Humans; D008297:Male; D008336:Mandibular Diseases / Q000209:etiology / Q000378:metabolism / Q000601:surgery*; D008875:Middle Aged; D016343:Monitoring, Intraoperative / Q000379:methods*; D010025:Osteoradionecrosis / Q000209:etiology / Q000378:metabolism / Q000601:surgery*; D011300:Preoperative Care; D013752:Tetracycline; D014466:Ultraviolet Rays
chemical_list: D005456:Fluorescent Dyes; D013752:Tetracycline