Myeloid C-type lectins in innate immunity.
C-type lectins expressed on myeloid cells comprise a family of proteins that share a common structural motif, and some act as receptors in pathogen recognition. But just as the presence of leucine-rich repeats alone is not sufficient to define a Toll-like receptor, the characterization of C-type lectin receptors in innate immunity requires the identification of accompanying signaling motifs. Here we focus on the known signaling pathways of myeloid C-type lectins and on their possible functions as autonomous activating or inhibitory receptors involved in innate responses to pathogens or self.
Robinson
Matthew J
MJ
Immunobiology Laboratory, Cancer Research UK, London Research Institute, London WC2A 3PX, United Kingdom.
Sancho
David
D
Slack
Emma C
EC
LeibundGut-Landmann
Salomé
S
Reis e Sousa
Caetano
C
D000818:Animals; D006801:Humans; D007113:Immunity, Innate; D007239:Infections / Q000276:immunology*; D037181:Lectins, C-Type / Q000276:immunology*; D051192:Receptors, Pattern Recognition / Q000276:immunology
D037181:Lectins, C-Type; D051192:Receptors, Pattern Recognition