title: Brain abscess following intracerebral haemorrhage.
abstract: We report two cases of brain abscess, which developed at the site of an intracerebral haemorrhage (ICH) in a 75-year-old man and a 32-year-old-man. The patients recovered after surgical treatment and systemic antibiotic therapy. The route of infection could not be detected in either case. The literature contains only 13 reported cases of brain abscess as a complication of ICH. Although the interval from initial ICH to abscess formation ranged from 4 to 20 weeks, almost all patients had episodes of high fever, indicating the presence of systemic infection and bacterial seeding, 0-14 days after the onset of their ICH. Therefore, abscess formation appears to be caused by haematogenous seeding of infection in patients with ICH. Abscess formation should be considered when a patient deteriorates clinically with a febrile episode after an ICH.
authors.affiliation: Department of Neurosurgery, Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences, Major of Functional and Regulatory Medical Sciences, University of Tsukuba, Tennodai 1-1-1, Tsukuba, Ibaraki, 305-8575 Japan.
authors.forename: K
authors.initials: K
authors.lastname: Nakai
authors.forename: T
authors.initials: T
authors.lastname: Yamamoto
authors.forename: S
authors.initials: S
authors.lastname: Yasuda
authors.forename: A
authors.initials: A
authors.lastname: Matsumura
mesh_terms: D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001424:Bacterial Infections / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D001812:Blood-Brain Barrier / Q000382:microbiology / Q000503:physiopathology; D001921:Brain / Q000098:blood supply / Q000382:microbiology* / Q000473:pathology*; D001922:Brain Abscess / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D020201:Brain Hemorrhage, Traumatic / Q000150:complications / Q000473:pathology / Q000503:physiopathology; D002543:Cerebral Hemorrhage / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D003428:Cross Infection / Q000150:complications / Q000382:microbiology / Q000503:physiopathology; D018450:Disease Progression; D042241:Early Diagnosis; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019635:Neurosurgical Procedures / Q000009:adverse effects; D013530:Surgical Wound Infection / Q000150:complications / Q000382:microbiology / Q000503:physiopathology; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents