title: The sensitivity of the OptiMAL rapid diagnostic test to the presence of Plasmodium falciparum gametocytes compromises its ability to monitor treatment outcomes in an area of Papua New Guinea in which malaria is endemic.
abstract: Using in vivo samples from treatment failure malaria cases, we demonstrate the high sensitivity of the parasite lactase dehydrogenase (pLDH)-based OptiMAL rapid diagnostic test in the detection of P. falciparum gametocytes. This high sensitivity limits the use of pLDH-based tests in the monitoring of treatment outcomes in circumstances where gametocytemia is common.
authors.affiliation: PNG Institute of Medical Research, P.O. Box 378, Madang 511, Papua New Guinea. pngimr_ivo@datec.net.pg
authors.forename: Ivo
authors.initials: I
authors.lastname: Mueller
authors.forename: Inoni
authors.initials: I
authors.lastname: Betuela
authors.forename: Meza
authors.initials: M
authors.lastname: Ginny
authors.forename: John C
authors.initials: JC
authors.lastname: Reeder
authors.forename: Blaise
authors.initials: B
authors.lastname: Genton
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000627:therapeutic use; D019353:Endemic Diseases; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000097:blood*; D016778:Malaria, Falciparum / Q000175:diagnosis / Q000188:drug therapy* / Q000469:parasitology; D016780:Malaria, Vivax / Q000188:drug therapy / Q000469:parasitology; D010219:Papua New Guinea; D018512:Parasitemia / Q000175:diagnosis / Q000188:drug therapy* / Q000469:parasitology; D010274:Parasitology / Q000379:methods; D010963:Plasmodium falciparum / Q000187:drug effects / Q000201:enzymology / Q000254:growth & development* / Q000302:isolation & purification; D011933:Reagent Kits, Diagnostic; D012680:Sensitivity and Specificity; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000962:Antimalarials; D011933:Reagent Kits, Diagnostic; D007770:L-Lactate Dehydrogenase