Central nervous system involvement in diabetes mellitus.
Diabetic complications result in much morbidity and mortality and considerable consumption of scarce medical resources. Thus, elucidation of the risk factors and pathophysiologic mechanisms underlying diabetic complications is important. The effects of diabetes on the central nervous system (CNS) result in cognitive dysfunction and cerebrovascular disease. Treatment-related hypoglycemia also has CNS consequences. Advances in neuroimaging now provide greater insights into the structural and functional impact of diabetes on the CNS. Greater understanding of CNS involvement could lead to new strategies to prevent or reverse the damage caused by diabetes mellitus.
Selvarajah
Dinesh
D
Tesfaye
Solomon
S
D050197:Atherosclerosis / Q000453:epidemiology / Q000503:physiopathology; D001786:Blood Glucose / Q000378:metabolism; D002493:Central Nervous System Diseases / Q000453:epidemiology / Q000209:etiology / Q000503:physiopathology*; D002543:Cerebral Hemorrhage / Q000453:epidemiology; D003072:Cognition Disorders; D048909:Diabetes Complications / Q000503:physiopathology*; D003925:Diabetic Angiopathies / Q000453:epidemiology / Q000503:physiopathology*; D006706:Homeostasis; D006801:Humans; D007003:Hypoglycemia; D007333:Insulin Resistance; D012307:Risk Factors; D020521:Stroke / Q000453:epidemiology
D001786:Blood Glucose