title: Evaluation of right and left ventricular function by quantitative blood-pool SPECT (QBS): comparison with conventional methods and quantitative gated SPECT (QGS).
abstract: Though quantitative ECG-gated blood-pool SPECT (QBS) has become a popular tool in research settings, more verification is necessary for its utilization in clinical medicine. To evaluate the reliability of the measurements of left and right ventricular functions with QBS, we performed QBS, as well as first-pass pool (FPP) and ECG-gated blood-pool (GBP) studies on planar images in 41 patients and 8 healthy volunteers. Quantitative ECG-gated myocardial perfusion SPECT (QGS) was also performed in 30 of 49 subjects. First, we assessed the reproducibility of the measurements of left and right ventricular ejection fraction (LVEF, RVEF) and left and right ventricular end-diastolic volume (LVEDV, RVEDV) with QBS. Second, LVEF and RVEF obtained from QBS were compared with those from FPP and GBP, respectively. Third, LVEF and LVEDV obtained from QBS were compared with those from QGS, respectively. The intra- and inter-observer reproducibilities were excellent for LVEF, LVEDV, RVEF and RVEDV measured with QBS (r = 0.88 to 0.96, p < 0.01), while the biases in the measurements of RVEF and RVEDV were relatively large. LVEF obtained from QBS correlated significantly with those from FPP and GBP, while RVEF from QBS did not. LVEF and LVEDV obtained from QBS were significantly correlated with those from QGS, but the regression lines were not close to the lines of identity. In conclusion, the measurements of LVEF and LVEDV with QBS have good reproducibility and are useful clinically, while those of RVEF and RVEDV are less useful compared with LVEF and LVEDV. The algorithm of QBS for the measurements of RVEF and RVEDV remains to be improved.
authors.affiliation: Division of Cardiology, Internal Medicine III, Hamamatsu University School of Medicine, Japan. k-altair@nifty.com
authors.forename: Keiichi
authors.initials: K
authors.lastname: Odagiri
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Wakabayashi
authors.forename: Kei
authors.initials: K
authors.lastname: Tawarahara
authors.forename: Chinori
authors.initials: C
authors.lastname: Kurata
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Urushida
authors.forename: Hideki
authors.initials: H
authors.lastname: Katoh
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Satoh
authors.forename: Hideharu
authors.initials: H
authors.lastname: Hayashi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004452:Echocardiography / Q000379:methods; D005260:Female; D015637:Gated Blood-Pool Imaging / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D019275:Radiopharmaceuticals / Q000494:pharmacology*; D015203:Reproducibility of Results; D013668:Technetium Tc 99m Aggregated Albumin / Q000494:pharmacology*; D016284:Technetium Tc 99m Pentetate / Q000494:pharmacology*; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*; D016277:Ventricular Function, Left; D016278:Ventricular Function, Right
chemical_list: D019275:Radiopharmaceuticals; D013668:Technetium Tc 99m Aggregated Albumin; C057162:technetium Tc 99m DTPA HSA; D016284:Technetium Tc 99m Pentetate