title: Analysis of the hierarchy of quorum-sensing regulation in Pseudomonas aeruginosa.
abstract: Quorum-sensing in Pseudomonas aeruginosa is known to regulate several aspects of pathogenesis, including virulence factor production, biofilm development, and antimicrobial resistance. Recent high-throughput analysis has revealed the existence of several layers of regulation within the QS-circuit. To address this complexity, mutations in genes encoding known or putative transcriptional regulators that were also identified as being regulated by the las and/or rhl QS systems were screened for their contribution in mediating several phenotypes, for example motility, secreted virulence products, and pathogenic capacity in a lettuce leaf model. These studies have further elucidated the potential contribution to virulence of these genes within the QS regulon.
authors.affiliation: Department of Microbiology and Immunology, School of Medicine and Dentistry, University of Rochester, Box 672, Rochester, NY 14642, USA.
authors.forename: Victoria E
authors.initials: VE
authors.lastname: Wagner
authors.forename: Luen-Luen
authors.initials: LL
authors.lastname: Li
authors.forename: Vincent M
authors.initials: VM
authors.lastname: Isabella
authors.forename: Barbara H
authors.initials: BH
authors.lastname: Iglewski
mesh_terms: D018407:Bacterial Physiological Phenomena; D015964:Gene Expression Regulation, Bacterial / Q000235:genetics; D009154:Mutation; D020411:Oligonucleotide Array Sequence Analysis; D011550:Pseudomonas aeruginosa / Q000235:genetics* / Q000472:pathogenicity* / Q000502:physiology; D053038:Quorum Sensing; D014157:Transcription Factors / Q000235:genetics; D014158:Transcription, Genetic; D014774:Virulence / Q000235:genetics
chemical_list: D014157:Transcription Factors