A simple track structure model of ion beam radiotherapy.
A simple radiotherapy ion beam calculation based on the cellular track structure model, using in vitro cell survival parameters fitted from recent experimental data, is presented. The calculation represents a single-fraction ion exposure (roughly corresponding to a 2 Gy fraction of megavolt X rays) and exploits concepts used in clinical radiotherapy, such as entrance, or 'skin' ion dose. The depth distribution of cells surviving their irradiation by a beam of 385 MeV amu(-1) carbon ions is calculated over the range of the stopping ions, as a sequence of track-segments, in the continuous slowing-down approximation. An interpretation of the 'clinical relative biological effectiveness' concept is suggested.
Waligórski
M P R
MP
Centre of Oncology, Garncarska 11, 31-115 Kraków, Poland. z5waligo@cyf-kr.edu.pl
Hollmark
M
M
Lesiak
J
J
D000818:Animals; D002470:Cell Survival / Q000528:radiation effects; D003198:Computer Simulation; D063193:Heavy Ion Radiotherapy; D006801:Humans; D018499:Linear Energy Transfer; D008954:Models, Biological; D009369:Neoplasms / Q000503:physiopathology / Q000532:radiotherapy*; D011874:Radiometry / Q000379:methods*; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*; D020266:Radiotherapy, Conformal / Q000379:methods*; D012542:Scattering, Radiation