title: Immunostimulating effects of the polyphenol-rich fraction of sugar cane (Saccharum officinarum L.) extract in chickens.
abstract: The phagocytic activity of peripheral blood leukocytes (PBL) in chickens orally administered sugar cane extracts (SCE) or polyphenol-rich fraction (PRF) of SCE (500 mg/kg/day) for 3 consecutive days increased significantly, when compared with that of saline-administered control chickens. Chickens orally administered SCE or PRF (500 mg/kg/day) for 3 consecutive days showed significantly higher antibody responses against sheep red blood cells and Brucella abortus than control chickens. In addition, oral administration of SCE or PRF also resulted in a significant increase in the number of IgM- and IgG-plaque forming cell responses of PBL, intestinal leukocytes and splenocytes, when compared with those of control chickens. Furthermore, delayed type hypersensitivity responses to human gamma globulin significantly increased in chickens orally administered SCE or PRF, compared with those of control chickens when evaluated on the basis of net increased wattle thickness at 24, 48 and 72 h after challenge. These results suggest that PRF of SCE has an immunostimulating effect in chickens.
authors.affiliation: Department of Parasitology, National Institute of Animal Health, Tsukuba, Ibaraki 305-0856, Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Hikosaka
authors.forename: Moshira
authors.initials: M
authors.lastname: El-Abasy
authors.forename: Yukari
authors.initials: Y
authors.lastname: Koyama
authors.forename: Maki
authors.initials: M
authors.lastname: Motobu
authors.forename: Kenji
authors.initials: K
authors.lastname: Koge
authors.forename: Takashi
authors.initials: T
authors.lastname: Isobe
authors.forename: Chung-Boo
authors.initials: CB
authors.lastname: Kang
authors.forename: Hideki
authors.initials: H
authors.lastname: Hayashidani
authors.forename: Takashi
authors.initials: T
authors.lastname: Onodera
authors.forename: Pi-Chao
authors.initials: PC
authors.lastname: Wang
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Matsumura
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Hirota
mesh_terms: D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D002003:Brucella abortus / Q000502:physiology; D002645:Chickens / Q000276:immunology* / Q000382:microbiology; D005419:Flavonoids / Q000008:administration & dosage / Q000494:pharmacology*; D007962:Leukocytes / Q000187:drug effects / Q000276:immunology; D010636:Phenols / Q000008:administration & dosage / Q000494:pharmacology*; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology; D059808:Polyphenols; D031786:Saccharum / Q000737:chemistry*; D012756:Sheep / Q000097:blood
chemical_list: D000276:Adjuvants, Immunologic; D005419:Flavonoids; D010636:Phenols; D010936:Plant Extracts; D059808:Polyphenols