title: Treatments in child and adolescent bipolar disorders.
abstract: The existence of bipolar disorder in adolescents is now clearly established. However, whether bipolarity exists in children is more controversial. We reviewed the literature on acute and prophylactic treatment of bipolar disorder in youths. The guidelines for the treatment of bipolar disorder in children and adolescents are generally similar to those applied in adult practice. But no evidence-based data support the use of mood stabilisers or antipsychotics since we only found two placebo-randomised controlled trials testing the efficacy of lithium in the paediatric literature. Therefore, we support the view that prescriptions should be limited to the most typical cases. In fact, the use of mood stabilisers or antipsychotics in the treatment of bipolar disorder in children and adolescents appears to be of limited use when a comorbid condition, such as attention deficit hyperactivity disorder, occurs unless aggressive behaviour is the target symptom.
authors.affiliation: Department of Child and Adolescent Psychiatry, Université Pierre et Marie Curie, Hôpital Pitié-Salpêtrière, AP-HP, 47 boulevard de l'Hôpital, 75013, Paris, France.
authors.forename: Angèle
authors.initials: A
authors.lastname: Consoli
authors.forename: Emmannuelle
authors.initials: E
authors.lastname: Deniau
authors.forename: Christophe
authors.initials: C
authors.lastname: Huynh
authors.forename: Diane
authors.initials: D
authors.lastname: Purper
authors.forename: David
authors.initials: D
authors.lastname: Cohen
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000374:Aggression / Q000187:drug effects; D000927:Anticonvulsants / Q000627:therapeutic use*; D018692:Antimanic Agents / Q000627:therapeutic use*; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D001289:Attention Deficit Disorder with Hyperactivity / Q000175:diagnosis / Q000188:drug therapy / Q000523:psychology; D001714:Bipolar Disorder / Q000175:diagnosis / Q000188:drug therapy* / Q000523:psychology; D002648:Child; D003937:Diagnosis, Differential; D006801:Humans; D016651:Lithium Carbonate / Q000627:therapeutic use; D016032:Randomized Controlled Trials as Topic; D055502:Secondary Prevention
chemical_list: D000927:Anticonvulsants; D018692:Antimanic Agents; D014150:Antipsychotic Agents; D016651:Lithium Carbonate