title: Derepression of excision of integrative and potentially conjugative elements from Streptococcus thermophilus by DNA damage response: implication of a cI-related repressor.
abstract: A DNA-damaging agent, mitomycin C, derepresses the site-specific excision of two integrative and potentially conjugative elements from Streptococcus thermophilus, ICESt1 and ICESt3. The regulation pathway involves a repressor related to phage lambda cI repressor. It could also involve a putative regulator related to another type of phage repressors, the "cI-like" repressors.
authors.affiliation: Laboratoire de Génétique et Microbiologie UMR1128, INRA, Faculté des Sciences et Techniques, Université Henri Poincaré Nancy 1, 1 Bd des Aiguillettes, BP239, F-54506 Vandoeuvre-lès-Nancy, France.
authors.forename: Xavier
authors.initials: X
authors.lastname: Bellanger
authors.forename: Catherine
authors.initials: C
authors.lastname: Morel
authors.forename: Bernard
authors.initials: B
authors.lastname: Decaris
authors.forename: Gérard
authors.initials: G
authors.lastname: Guédon
mesh_terms: D004249:DNA Damage; D004268:DNA-Binding Proteins / Q000378:metabolism*; D015964:Gene Expression Regulation, Bacterial / Q000502:physiology*; D016685:Mitomycin / Q000494:pharmacology; D019384:Nucleic Acid Synthesis Inhibitors / Q000494:pharmacology; D012097:Repressor Proteins / Q000378:metabolism*; D048249:Streptococcus thermophilus / Q000235:genetics* / Q000378:metabolism*; D014764:Viral Proteins / Q000378:metabolism*; D054334:Viral Regulatory and Accessory Proteins
chemical_list: D004268:DNA-Binding Proteins; D019384:Nucleic Acid Synthesis Inhibitors; D012097:Repressor Proteins; D014764:Viral Proteins; D054334:Viral Regulatory and Accessory Proteins; C016649:phage repressor proteins; D016685:Mitomycin