title: Determination of glucuronidated 5-hydroxytryptophol (GTOL), a marker of recent alcohol intake, by ELISA technique.
abstract: OBJECTIVE
  To compare markers of alcohol consumption.
  
  
  METHODS
  Measurement of urinary ethyl glucuronide, 5-hydroxytryptophol, 5-hydroxytryptophol glucuronide, 5-hydroxyindole acetic acid in 10 patients during alcohol withdrawal.
  
  
  RESULTS
  5-Hydroxytryptophol glucuronide was measured by ELISA with good analytical precision, its diagnostic specificity and sensitivity was better than that of 5-hydroxytryptophol and its correlation was closer to ethyl glucuronide than to 5-hydroxytryptophol.
  
  
  CONCLUSIONS
  Determination of 5-hydroxytryptophol glucuronide by ELISA offers promising results in detection of previous alcohol consumption.
authors.affiliation: Institute of Clinical Chemistry, Otto von Guericke University, Magdeburg, Germany.
authors.forename: Jutta
authors.initials: J
authors.lastname: Dierkes
authors.forename: Manfred
authors.initials: M
authors.lastname: Wolfersdorf
authors.forename: Katrin
authors.initials: K
authors.lastname: Borucki
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Weinmann
authors.forename: Gerhard
authors.initials: G
authors.lastname: Wiesbeck
authors.forename: Olof
authors.initials: O
authors.lastname: Beck
authors.forename: Stefan
authors.initials: S
authors.lastname: Borg
authors.forename: Friedrich M
authors.initials: FM
authors.lastname: Wurst
mesh_terms: D000328:Adult; D000428:Alcohol Drinking / Q000378:metabolism*; D015415:Biomarkers / Q000032:analysis; D004797:Enzyme-Linked Immunosorbent Assay; D020719:Glucuronides / Q000032:analysis*; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000032:analysis; D006917:Hydroxytryptophol / Q000031:analogs & derivatives* / Q000032:analysis*; D008297:Male; D013375:Substance Withdrawal Syndrome
chemical_list: C500750:5-hydroxytryptophol glucuronide; D015415:Biomarkers; D020719:Glucuronides; D006917:Hydroxytryptophol; D006897:Hydroxyindoleacetic Acid