Chili, but not turmeric, inhibits iron absorption in young women from an iron-fortified composite meal.
Chili and turmeric are common spices in indigenous diets in tropical regions. Being rich in phenolic compounds, they would be expected to bind iron (Fe)(3) in the intestine and inhibit Fe absorption in humans. Three experiments were conducted in healthy young women (n = 10/study) to assess the effect of chili and turmeric on Fe absorption from a rice-based meal containing vegetables and iron fortified fish sauce in vivo. Iron absorption was determined by erythrocyte incorporation of stable isotope labels ((57)Fe/(58)Fe) using a randomized crossover design. Addition of freeze-dried chili (4.2 g dry powder, 25 mg polyphenols as gallic acid equivalents) reduced Fe absorption from the meal by 38% (6.0% with chili vs. 9.7% without chili, P = 0.0017). Turmeric (0.5 g dry powder, 50 mg polyphenols as gallic acid equivalents) did not inhibit iron absorption (P = 0.91). A possible effect of chili on gastric acid secretion was indirectly assessed by comparing Fe absorption from acid soluble [(57)Fe]-ferric pyrophosphate relative to water soluble [(58)Fe]-ferrous sulfate from the same meal in the presence and absence of chili. Chili did not enhance gastric acid secretion. Relative Fe bioavailability of ferric pyrophosphate was 5.4% in presence of chili and 6.4% in absence of chili (P = 0.47). Despite the much higher amount of phenolics in the turmeric meal, it did not affect iron absorption. We conclude that both phenol quality and quantity determine the inhibitory effect of phenolic compounds on iron absorption.
Tuntipopipat
Siriporn
S
Institute of Nutrition, Mahidol University, Nakhon Pathom, Thailand.
Judprasong
Kunchit
K
Zeder
Christophe
C
Wasantwisut
Emorn
E
Winichagoon
Pattanee
P
Charoenkiatkul
Somsri
S
Hurrell
Richard
R
Walczyk
Thomas
T
D000328:Adult; D002212:Capsicum; D018592:Cross-Over Studies; D030024:Curcuma; D003474:Curcumin / Q000494:pharmacology*; D004032:Diet; D019587:Dietary Supplements; D005260:Female; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects*; D007501:Iron / Q000378:metabolism*; D007503:Iron Isotopes / Q000378:metabolism; D013785:Thailand; D014675:Vegetables
D007503:Iron Isotopes; D007501:Iron; D003474:Curcumin