Acute renal failure in a patient with paroxysmal cold hemoglobinuria.
Acute renal failure following auto-immune hemolysis is rare. We report a child with acute paroxysmal cold hemoglobinuria (PCH) complicated by renal failure. She was treated by peritoneal dialysis and red blood cell transfusion. After 2 weeks she had made a complete recovery with a normal blood count and renal profile, and the peritoneal dialysis catheter was removed. Extensive investigation, including an analysis of heme oxygenase-1 gene promoter region polymorphisms, failed to identify a cause for the renal failure in this patient.
Hothi
Daljit K
DK
Regional Paediatric Nephro-Urology Service, Southampton General Hospital, Tremona Road, Southampton, SO16 6YD, UK.
Bass
Paul
P
Morgan
Mary
M
Acharya
Jayshree
J
Humphries
Steve E
SE
Gilbert
Rodney D
RD
D058186:Acute Kidney Injury / Q000209:etiology* / Q000628:therapy; D002675:Child, Preschool; D005260:Female; D006457:Hemoglobinuria, Paroxysmal / Q000150:complications* / Q000175:diagnosis; D006801:Humans