In vivo study of propolis supplementation effects on antioxidative status and red blood cells.
In vivo study has been conducted on 47 healthy women and men in order to investigate whether daily intake of powdered propolis extract during 30 days has any influence on the following blood parameters: activity of superoxide dismutase, glutathione peroxidase and catalase, concentration of plasma malondialdehyde, total cholesterol, low- and high-density lipoprotein cholesterol, triglycerides, glucose, uric acid, ferritin and transferrin, together with routine red blood cell parameters. The effect of daily propolis intake seems to be time and gender related. For the men test group after the initial 15 days of propolis treatment, 23.2% (p=0.005) decrease in concentration of malondialdehyde was observed. After 30 days of treatment, statistically significant (p=0.010) 20.9% increase in superoxide dismutase activity and change in some of the red blood cell parameters were detected. For the women test group, the propolis treatment did not induce a change in any of the measured parameters.
Jasprica
Ivona
I
Department of Medicinal Chemistry, University of Zagreb, A. Kovacića 1, 10 000 Zagreb, Croatia.
Mornar
Ana
A
Debeljak
Zeljko
Z
Smolcić-Bubalo
Asja
A
Medić-Sarić
Marica
M
Mayer
Ljiljana
L
Romić
Zeljko
Z
Bućan
Kajo
K
Balog
Tihomir
T
Sobocanec
Sandra
S
Sverko
Visnja
V
D000328:Adult; D000975:Antioxidants / Q000494:pharmacology*; D001786:Blood Glucose / Q000187:drug effects; D002374:Catalase / Q000187:drug effects / Q000378:metabolism; D002784:Cholesterol / Q000097:blood; D004912:Erythrocytes / Q000187:drug effects* / Q000502:physiology; D005260:Female; D005293:Ferritins / Q000097:blood / Q000187:drug effects; D005419:Flavonoids / Q000008:administration & dosage / Q000494:pharmacology*; D005979:Glutathione Peroxidase / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D011429:Propolis / Q000008:administration & dosage / Q000494:pharmacology*; D012737:Sex Factors; D013482:Superoxide Dismutase / Q000187:drug effects / Q000378:metabolism; D014168:Transferrin / Q000187:drug effects / Q000502:physiology; D014280:Triglycerides / Q000097:blood; D014527:Uric Acid / Q000097:blood
D000975:Antioxidants; D001786:Blood Glucose; D005419:Flavonoids; D014168:Transferrin; D014280:Triglycerides; D014527:Uric Acid; D008315:Malondialdehyde; D005293:Ferritins; D011429:Propolis; D002784:Cholesterol; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase