title: Kahalalide derivatives from the Indian sacoglossan mollusk Elysia grandifolia.
abstract: Two new cyclic depsipeptide derivatives, kahalalides R (1) and S (2), together with two known congeners, kahalalides F (3) and D (4), were isolated from the Indian sacoglossan mollusk Elysia grandifolia. The structures of the new compounds were unambiguously established on the basis of NMR spectroscopic (1H, 13C, COSY, HMBC) and mass spectrometric (FABMS, ESIMS, MALDI-TOF/PSD) data, which also included Marfey amino acid analyses. The new derivative kahalalide R was found to exert comparable or even higher cytotoxicity than the potential drug candidate kahalalide F toward the MCF7 human mammary carcinoma cell line.
authors.affiliation: Institut für Pharmazeutische Biologie und Biotechnologie, Heinrich-Heine-Universität Düsseldorf, Universitätsstrasse 1, Geb. 26.23, 40225 Düsseldorf, Germany.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Ashour
authors.forename: RuAngelie
authors.initials: R
authors.lastname: Edrada
authors.forename: Rainer
authors.initials: R
authors.lastname: Ebel
authors.forename: Victor
authors.initials: V
authors.lastname: Wray
authors.forename: Wim
authors.initials: W
authors.lastname: Wätjen
authors.forename: K
authors.initials: K
authors.lastname: Padmakumar
authors.forename: Werner E G
authors.initials: WE
authors.lastname: Müller
authors.forename: Wen Han
authors.initials: WH
authors.lastname: Lin
authors.forename: Peter
authors.initials: P
authors.lastname: Proksch
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D045744:Cell Line, Tumor; D047630:Depsipeptides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006801:Humans; D019156:Indian Ocean; D015674:Mammary Neoplasms, Animal; D015394:Molecular Structure; D008974:Mollusca / Q000737:chemistry*; D019906:Nuclear Magnetic Resonance, Biomolecular
chemical_list: D000970:Antineoplastic Agents; D047630:Depsipeptides; C516605:kahalalide R; C516606:kahalalide S; C097897:kahalalide F