Expression of phosphorylcholine by Histophilus somni induces bovine platelet aggregation.
Histophilus somni-induced platelet aggregation was inhibited by antagonists of the platelet-activating factor (PAF) receptor but not inhibitors of PAF synthesis. In addition, H. somni cells expressing phosphorylcholine (ChoP) induced aggregation, while ChoP(-) H. somni cells did not. This suggests that H. somni ChoP may induce platelet aggregation via interactions with the PAF receptor.
Kuckleburg
Christopher J
CJ
Department of Pathobiological Sciences, School of Veterinary Medicine, 2015 Linden Drive West, Madison, WI 53706, USA.
Elswaifi
Shaadi F
SF
Inzana
Thomas J
TJ
Czuprynski
Charles J
CJ
D000818:Animals; D001422:Bacterial Adhesion; D001792:Blood Platelets / Q000382:microbiology; D002417:Cattle; D015661:Pasteurellaceae / Q000235:genetics / Q000502:physiology*; D010767:Phosphorylcholine / Q000378:metabolism*; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors; D015539:Platelet Activation; D010974:Platelet Aggregation; D010980:Platelet Membrane Glycoproteins / Q000037:antagonists & inhibitors / Q000378:metabolism; D043562:Receptors, G-Protein-Coupled / Q000037:antagonists & inhibitors / Q000378:metabolism; D015398:Signal Transduction
D010972:Platelet Activating Factor; D010980:Platelet Membrane Glycoproteins; D043562:Receptors, G-Protein-Coupled; C039351:platelet activating factor receptor; D010767:Phosphorylcholine