title: [Influence of selected Lactobacillus sp. on Clostridium difficile strains with different toxigenicity profile].
abstract: This study was performed for determination of antagonistic activity of Lactobacillus spp. (L. plantarum 2017405, L. rhamnosus GG, L. acidophilus DSM 21007 and L. fernmentumn 353) on Clostridiunl difficile strains belonging to different toxigenicity profiles. Forty strains C. difficile isolated from patients suffering from antibiotic associated diarrhea (AAD) were used. Among C. difficile strains 13 produced toxin A and B (A+B+CDT-), 14 produced only toxin B (AB'CDT), 9 produced toxins A and B and possessing of binary toxin genes (A+B+CDT-) and 4 were non-toxigenic (A-B-CDT-). We did not observe relationship between degree of antagonistic activity Lactobacillus spp. and profile of toxigenicity of C. difficile strains.
authors.affiliation: Katedra i Zakład Mikrobiologii Lekarskiej AM w Warszawie.
authors.forename: Dorota
authors.initials: D
authors.lastname: Wultańska
authors.forename: Hanna
authors.initials: H
authors.lastname: Pituch
authors.forename: Piotr
authors.initials: P
authors.lastname: Obuch-Woszczatyński
authors.forename: Felicja
authors.initials: F
authors.lastname: Meisel-Mikołajczyk
authors.forename: Mirosław
authors.initials: M
authors.lastname: Luczak
mesh_terms: D000898:Antibiosis / Q000502:physiology*; D001426:Bacterial Proteins; D001427:Bacterial Toxins; D016360:Clostridioides difficile / Q000145:classification* / Q000472:pathogenicity*; D003967:Diarrhea / Q000382:microbiology*; D004768:Enterotoxins / Q000032:analysis / Q000235:genetics* / Q000378:metabolism; D005243:Feces / Q000382:microbiology; D006801:Humans; D007422:Intestines / Q000382:microbiology; D019344:Lactic Acid / Q000378:metabolism; D007780:Lacticaseibacillus casei / Q000145:classification / Q000378:metabolism*; D011044:Poland; D014774:Virulence
chemical_list: D001426:Bacterial Proteins; D001427:Bacterial Toxins; D004768:Enterotoxins; C041348:tcdA protein, Clostridium difficile; C031815:toxB protein, Clostridium difficile; D019344:Lactic Acid