Chiral multinuclear macrocyclic polyamine complexes: synthesis, characterization and their interaction with plasmid DNA.
A series of multinuclear macrocyclic polyamine metal (Zn(2+), Cu(2+), Co(2+)) complexes containing chiral dipeptide linkage were synthesized and used as artificial nuclease enzyme model. The interaction between the complexes and plasmid DNA (pUC19) was studied, and the results revealed that these complexes could act as powerful catalysts for the cleavage of plasmid DNA under physiological conditions.
Fang
Yu-Guo
YG
Department of Chemistry, Key Laboratory of Green Chemistry and Technology (Ministry of Education), Sichuan University, 29 Wangjiang Road, Chengdu, Sichuan 610064, PR China.
Zhang
Ji
J
Chen
Shan-Yong
SY
Jiang
Ning
N
Lin
Hong-Hui
HH
Zhang
Yu
Y
Yu
Xiao-Qi
XQ
D002384:Catalysis; D003035:Cobalt / Q000737:chemistry / Q000494:pharmacology; D003300:Copper / Q000737:chemistry / Q000494:pharmacology; D004247:DNA / Q000187:drug effects*; D003851:Deoxyribonucleases / Q000737:chemistry; D007202:Indicators and Reagents; D047028:Macrocyclic Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D010957:Plasmids / Q000187:drug effects*; D011073:Polyamines / Q000138:chemical synthesis* / Q000494:pharmacology*; D021241:Spectrometry, Mass, Electrospray Ionization; D015032:Zinc / Q000737:chemistry / Q000494:pharmacology
D007202:Indicators and Reagents; D047028:Macrocyclic Compounds; D011073:Polyamines; D003035:Cobalt; D003300:Copper; D004247:DNA; D003851:Deoxyribonucleases; D015032:Zinc