A nitrogen-containing 3-alkyl-1,4-benzoquinone and a gomphilactone derivative from Embelia ribes.
An unusual nitrogen-containing 3-alkyl-1,4-benzoquinone derivative, N-(3-carboxylpropyl)-5-amino-2-hydroxy-3-tridecyl-1,4-benzoquinone (1), and a gomphilactone derivative, 5,6-dihydroxy-7-tridecyl-3-[4-tridecyl-3-hydroxy-5-oxo-2(5H)-furylidene]-2-oxo-3(2H)-benzofuran (2), together with 14 known compounds, as well as the common plant metabolites sitosterol and daucosterol, were isolated from the ethanolic extract of the roots of Embelia ribes. Their structures were elucidated by means of spectroscopic methods. Cytotoxicities of the purified compounds were tested.
Lin
Pengcheng
P
Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College (Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education), Beijing, People's Republic of China.
Li
Shuai
S
Wang
Sujuan
S
Yang
Yongchun
Y
Shi
Jiangong
J
D016227:Benzoquinones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D031645:Embelia / Q000737:chemistry*; D006801:Humans; D020128:Inhibitory Concentration 50; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D009584:Nitrogen / Q000737:chemistry; D019906:Nuclear Magnetic Resonance, Biomolecular; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*
D016227:Benzoquinones; D004365:Drugs, Chinese Herbal; D007783:Lactones; D009584:Nitrogen