title: [Endocarditis due to meticillin-resistant Staphylococcus aureus originating from pigs].
abstract: A 63-year-old woman with a kidney transplant was admitted with endocarditis caused by meticillin-resistant Staphylococcus aureus (MRSA). Once her antibiotic therapy had been adjusted to the sensitivity-pattern of the bacterial strain she recovered, without the need for surgical intervention. The isolated S. aureus was typed by multi-locus sequence typing as sequence type 398, a MRSA-strain that has recently been isolated from a high percentage of Dutch pigs. This is the first report of a life-threatening infection with this pig MRSA. This strain is genetically different from the globally dispersed nosocomial MRSA-strains, and also from the strains that have been epidemic for several years in the USA as the causative agent ofcommunity-acquired skin infections. The Dutch Working Group on Infection Prevention (WIP) has recently adjusted its guidelines to halt further spread of this strain, and advises that the population at risk (pig breeders, slaughterhouse personnel and veterinarians) be held in isolation when hospitalised until MRSA colonisation has been excluded. The patient described here, however, did not belong to this population at risk.
authors.affiliation: Universitair Medisch Centrum Utrecht, Postbus 85.500, 3508 GA Utrecht. m.ekkelenkamp@umcutrecht.nl
authors.forename: M B
authors.initials: MB
authors.lastname: Ekkelenkamp
authors.forename: M
authors.initials: M
authors.lastname: Sekkat
authors.forename: N
authors.initials: N
authors.lastname: Carpaij
authors.forename: A
authors.initials: A
authors.lastname: Troelstra
authors.forename: M J M
authors.initials: MJ
authors.lastname: Bonten
mesh_terms: D000818:Animals; D004697:Endocarditis, Bacterial / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology / Q000635:transmission; D005260:Female; D006801:Humans; D016106:Methicillin Resistance; D008875:Middle Aged; D013203:Staphylococcal Infections / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology / Q000635:transmission; D013211:Staphylococcus aureus / Q000187:drug effects / Q000235:genetics / Q000254:growth & development; D013552:Swine; D013553:Swine Diseases / Q000382:microbiology* / Q000635:transmission; D015047:Zoonoses