title: The influence of the deletion on the long arm of the Y chromosome on sperm motility in mice.
abstract: The multicopy region on the long arm of the mouse Y chromosome contains four known genes. There are evidences that deletions in this region lead to decrease of sperm quality in mutant mice. Male mice completely lacking this region are infertile. Here we report results obtained by using the computer assisted semen analysis system (CASA), describing the movement parameters of spermatozoa from mutant males with partial deletion on the long arm of the Y chromosome (B10. BR-Y(del)). First we have determined that genes necessary for spermiogenesis and located in this region are still active in mutants, than we have compared the sperm movement of mutants and control animals. This analysis revealed that the Yq deletion affects: velocity parameters (VAP, VCL, VSL), parameters describing sperm head activity during movement (ALH and BCF) and linearity (LIN) of movement. Our findings indicate that sperm movement is controlled by genes located in the long arm of the Y chromosome.
authors.affiliation: Department of Genetics and Evolution, Institute of Zoology, Jagiellonian University, Ingardena 6, 30-060 Kraków, Poland. grzmil@zuk.iz.uj.edu.pl
authors.forename: Paweł
authors.initials: P
authors.lastname: Grzmil
authors.forename: Aniela
authors.initials: A
authors.lastname: Gołas
authors.forename: Christian
authors.initials: C
authors.lastname: Müller
authors.forename: Józefa
authors.initials: J
authors.lastname: Styrna
mesh_terms: D000818:Animals; D002872:Chromosome Deletion; D005786:Gene Expression Regulation; D008297:Male; D051379:Mice / Q000235:genetics*; D011506:Proteins / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction / Q000662:veterinary; D013081:Sperm Motility / Q000235:genetics*; D014998:Y Chromosome
chemical_list: D011506:Proteins; C491842:Ssty1 protein, mouse