title: Delayed early proprioceptive information processing in schizophrenia.
abstract: It was first suggested that disordered proprioception was a core feature of schizophrenia by Sandor Rado in 1953. Using a recently designed proprioceptive event-related potential paradigm based on a change of load, we studied 12 unmedicated male out-patients with schizophrenia and 24 controls. In the patients, the early contralateral parietal activity was delayed and later central activity had increased amplitude, but gating was unaffected. The results could be understood within the "deficiency of corollary discharge" model of schizophrenia but not within the "filtering" theory. Further studies, including psychiatric controls, are necessary to verify the specificity of the abnormality.
authors.affiliation: Department of Psychiatry, Hvidovre Hospital,University Hospital of Copenhagen, Brøndbyøstervej 160, 2605 Brøndby, Denmark. s.arnfred@tdcadsl.dk
authors.forename: Sidse M
authors.initials: SM
authors.lastname: Arnfred
authors.forename: Ralf P
authors.initials: RP
authors.lastname: Hemmingsen
authors.forename: Josef
authors.initials: J
authors.lastname: Parnas
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D005073:Evoked Potentials, Somatosensory / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011434:Proprioception / Q000502:physiology*; D011930:Reaction Time; D012565:Schizophrenic Psychology; D020886:Somatosensory Disorders / Q000209:etiology / Q000503:physiopathology*