'Click peptide': a novel 'O-acyl isopeptide method' for peptide synthesis and chemical biology-oriented synthesis of amyloid beta peptide analogues.
After over a decade of studies on aspartic protease inhibitors and water-soluble prodrugs, we have been developing a novel method, since 2003, called 'O-acyl isopeptide method', for the synthesis of peptides containing difficult sequences. With our recent discoveries of 'O-acyl isodipeptide unit' and the 'racemization-free segment condensation method', this method has further evolved as a general synthetic method for peptides. Moreover, 'Click Peptide', which could be a powerful tool for identifying the pathological functions of amyloid beta peptides in Alzheimer's disease, represents a valuable use of the isopeptide method in Chemical Biology-oriented research.
Sohma
Youhei
Y
Department of Medicinal Chemistry, Center for Frontier Research in Medicinal Science, 21st Century COE Program, Kyoto Pharmaceutical University, Yamashina-ku, Kyoto 607-8412.
Taniguchi
Atsuhiko
A
Yoshiya
Taku
T
Chiyomori
Yousuke
Y
Fukao
Fukue
F
Nakamura
Setsuko
S
Skwarczynski
Mariusz
M
Okada
Takuma
T
Ikeda
Keisuke
K
Hayashi
Yoshio
Y
Kimura
Tooru
T
Hirota
Shun
S
Matsuzaki
Katsumi
K
Kiso
Yoshiaki
Y
D000215:Acylation; D000595:Amino Acid Sequence; D016229:Amyloid beta-Peptides / Q000138:chemical synthesis* / Q000737:chemistry; D004355:Drug Stability; D008956:Models, Chemical; D008969:Molecular Sequence Data; D015394:Molecular Structure; D010446:Peptide Fragments / Q000138:chemical synthesis* / Q000737:chemistry; D011355:Prodrugs / Q000138:chemical synthesis / Q000737:chemistry
D016229:Amyloid beta-Peptides; D010446:Peptide Fragments; D011355:Prodrugs