title: Rearrangement of 3,3-disubstituted indolenines and synthesis of 2,3-substituted indoles.
abstract: Synthesis of 2,3-substituted indoles from phenylhydrazine and alpha-branched aldehydes via rearrangement of 3,3-disubstituted indolenine intermediates is reported. [reaction: see text]
authors.affiliation: Chemical & Screening Sciences, Wyeth Research, CN 8000, Princeton, NJ 08543, USA. liuk1@wyeth.com
authors.forename: Kevin G
authors.initials: KG
authors.lastname: Liu
authors.forename: Albert J
authors.initials: AJ
authors.lastname: Robichaud
authors.forename: Jennifer R
authors.initials: JR
authors.lastname: Lo
authors.forename: James F
authors.initials: JF
authors.lastname: Mattes
authors.forename: Yanxuan
authors.initials: Y
authors.lastname: Cai
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D002384:Catalysis; D007211:Indoles / Q000138:chemical synthesis*; D009682:Magnetic Resonance Spectroscopy; D010659:Phenylhydrazines / Q000737:chemistry; D012997:Solvents
chemical_list: D000447:Aldehydes; D007211:Indoles; D010659:Phenylhydrazines; D012997:Solvents; C030299:phenylhydrazine