N-H carbazole synthesis from 2-chloroanilines via consecutive amination and C-H activation.
N-H carbazoles can be produced from 2-chloroanilines and aryl bromides via consecutive catalytic amination and C-H activation. In many instances, this can be done in a tandem manner in one pot. The methodologies developed can be used in the synthesis of a range of carbazoles, including the natural products Clausine P and glycozolidine and a precursor in the synthesis of Clausines H, K, O, and 7-methoxy-O-methylmukonal, and can be extended to the synthesis of indoles.
Bedford
Robin B
RB
School of Chemistry, University of Bristol, Cantock's Close, Bristol, BS8 1TS, UK. r.bedford@bristol.ac.uk
Betham
Michael
M