title: Platelet activation in different clinical forms of the coronary artery disease (role of P-selectin and others platelet markers in stable and unstable angina).
abstract: OBJECTIVE
  Markers of platelet activation are elevated in coronary artery disease. We sought to identify the presence and the potential associations of different markers of platelet activation.
  
  
  METHODS
  We studied patients with unstable angina (n=28), patients with stable angina (n=36) and patients without coronary artery disease (n=30); sex and age matched. Blood levels of the adhesion molecule P-selectin, Thromboxane B2 and Serotonin were measured by enzyme immunoassays.
  
  
  RESULTS
  When we compared the groups the results were: sP-selectin, thromboxane B2 and serotonin levels were significantly higher in patients with unstable angina than in patients with stable angina.
  
  
  CONCLUSIONS
  These markers of platelet activation were able to identify unstable forms of coronary artery disease.
authors.affiliation: Instituto do Coração, Hospital das Clínicas, FM, USP, São Paulo, SP.
authors.forename: Margareth L
authors.initials: ML
authors.lastname: Venturinelli
authors.forename: André
authors.initials: A
authors.lastname: Hovnan
authors.forename: Alexandre de Matos
authors.initials: Ade M
authors.lastname: Soeiro
authors.forename: José Carlos
authors.initials: JC
authors.lastname: Nicolau
authors.forename: José A F
authors.initials: JA
authors.lastname: Ramires
authors.forename: Elbio A
authors.initials: EA
authors.lastname: D'Amico
authors.forename: Carlos Vicente
authors.initials: CV
authors.lastname: Serrano
mesh_terms: D000787:Angina Pectoris / Q000097:blood / Q000503:physiopathology*; D015415:Biomarkers / Q000097:blood; D003324:Coronary Artery Disease / Q000097:blood / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019007:P-Selectin / Q000097:blood; D015539:Platelet Activation / Q000502:physiology*; D012701:Serotonin / Q000097:blood; D013929:Thromboxane B2 / Q000097:blood
chemical_list: D015415:Biomarkers; D019007:P-Selectin; D012701:Serotonin; D013929:Thromboxane B2