A complex translocation (6;12;8)(q25;q24.3;q13) in a fibrous hamartoma of infancy.
We report the case of an 18-month-old girl who came to medical attention with a left cervical mass. Surgical excision was performed 16 months later. Histology revealed a fibrous hamartoma of infancy. Follow-up has been uneventful, and no recurrence of the mass has been observed. Cytogenetic analysis showed a complex translocation involving chromosomes 6, 8, and 12, namely, t(6;12;8)(q25;q24.3;q13). This case represents the second cytogenetic analysis reported to date in fibrous hamartoma of infancy and reveals a different translocation than the reciprocal translocation t(2;3)(q31;q21) previously reported.
Rougemont
Anne-Laure
AL
Department of Pathology, CHU Sainte-Justine, 3175, Côte-Sainte-Catherine, Montréal, Quebec, Canada.
Fetni
Raouf
R
Murthy
Sabita
S
Fournet
Jean-Christophe
JC
D002675:Child, Preschool; D002881:Chromosomes, Human, Pair 12; D002896:Chromosomes, Human, Pair 6; D002898:Chromosomes, Human, Pair 8; D005260:Female; D006222:Hamartoma / Q000235:genetics* / Q000473:pathology; D006258:Head and Neck Neoplasms / Q000235:genetics / Q000473:pathology; D006801:Humans; D007223:Infant; D018218:Neoplasms, Fibrous Tissue / Q000235:genetics / Q000473:pathology; D012983:Soft Tissue Neoplasms / Q000235:genetics / Q000473:pathology; D014178:Translocation, Genetic