Single-dose intravenous simvastatin treatment attenuates renal injury in an experimental model of ischemia-reperfusion in the rat.
The effect of acute pretreatment with a single dose of simvastatin (1 mg/kg, i.v.; 30 min before ischemia) on renal dysfunction caused by ischemia-reperfusion (I/R) injury in the rat was investigated. I/R injury was induced by clamping both renal vascular pedicles for 45 min, followed by 4 h of reperfusion with saline (2 ml/kg per hour). Simvastatin significantly improved both parameters of glomerular and tubular dysfunction (e.g., creatinine levels and fractional excretion of Na(+), respectively) and especially improved the histological score, compared to control I/R-injured rats treated with saline or 10% DMSO only.
Nesić
Zorica
Z
Department of Pharmacology, Clinical Pharmacology and Toxicology, School of Medicine, University of Belgrade, Serbia and Montenegro.
Todorović
Zoran
Z
Stojanović
Radan
R
Basta-Jovanović
Gordana
G
Radojević-Skodrić
Sanja
S
Velicković
Ruzica
R
Chatterjee
Prabal K
PK
Thiemermann
Christoph
C
Prostran
Milica
M
D000818:Animals; D003404:Creatinine / Q000097:blood; D004195:Disease Models, Animal; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D007275:Injections, Intravenous; D007668:Kidney / Q000098:blood supply / Q000187:drug effects* / Q000473:pathology; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000097:blood / Q000473:pathology / Q000517:prevention & control* / Q000652:urine; D019821:Simvastatin / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D012964:Sodium / Q000652:urine; D014508:Urea / Q000097:blood
D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D014508:Urea; D012964:Sodium; D019821:Simvastatin; D003404:Creatinine