title: Mutant presenilin 2 causes abnormality in the brain lipid profile in the development of Alzheimer's disease.
abstract: Mutation in the presenilin 2 (PS2mt) is known to be one of factors involved in the development of Alzheimer's disease (AD). It was recently revealed that an abnormality of lipid metabolism is a phenomenon occurring in AD. Therefore, the aim of this study was to investigate the potential relationship between the mutation of PS2 and alterations of the lipid profile within the brain. The results showed there increases in the levels of cholesterol, low density lipoprotein and triglyceride, but a decrease in the level of high density lipoprotein in brain tissues expressing mutant PS2. These findings indicated that PS2mt is involved in the abnormalities of the lipid profile, which could cause or result in the development of AD.
authors.affiliation: College of Pharmacy and CBITRC, Chungbuk National University, Cheongju 361-763, Korea.
authors.forename: Hong Nga
authors.initials: HN
authors.lastname: Nguyen
authors.forename: Dong Ju
authors.initials: DJ
authors.lastname: Son
authors.forename: Jae Woong
authors.initials: JW
authors.lastname: Lee
authors.forename: Dae Youn
authors.initials: DY
authors.lastname: Hwang
authors.forename: Young Kyu
authors.initials: YK
authors.lastname: Kim
authors.forename: Jeong Sik
authors.initials: JS
authors.lastname: Cho
authors.forename: Ung Soo
authors.initials: US
authors.lastname: Lee
authors.forename: Hwan Soo
authors.initials: HS
authors.lastname: Yoo
authors.forename: Dong Cheul
authors.initials: DC
authors.lastname: Moon
authors.forename: Ki Wan
authors.initials: KW
authors.lastname: Oh
authors.forename: Jin Tae
authors.initials: JT
authors.lastname: Hong
mesh_terms: D000367:Age Factors; D000544:Alzheimer Disease / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000378:metabolism*; D002784:Cholesterol / Q000378:metabolism*; D008076:Cholesterol, HDL / Q000378:metabolism; D008078:Cholesterol, LDL / Q000378:metabolism; D003124:Colorimetry / Q000379:methods; D050356:Lipid Metabolism; D008074:Lipoproteins / Q000378:metabolism*; D051379:Mice; D008822:Mice, Transgenic; D009154:Mutation / Q000235:genetics*; D053766:Presenilin-2 / Q000235:genetics*; D014280:Triglycerides / Q000378:metabolism
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008074:Lipoproteins; D053766:Presenilin-2; D014280:Triglycerides; D002784:Cholesterol