title: Phytate acts as an inhibitor in formation of renal calculi.
abstract: The aim of this study was to assess the inhibitory action of phytate in formation of renal calculi. Hypertension (induced by nicotine) combined with hypercalcemia (induced by D vitamin) was used to induce calcification in renal tissue in male Wistar rats that were fed a purified phytate free diet. Phytate non-treated rats developed significant calcium deposits in kidneys and papillae, as well as in kidney tubules and vessels, whereas calcium deposits were absent in control and phytate treated rats. Fragments of hydroxyapatite (HAP) calculi exhibited the capacity to induce the growth of calcium salts on their surfaces. Presence of 1.5 mg/L of phytate in the synthetic urine inhibited the formation of calcium oxalate monohydrate on HAP renal calculi in normocalciuric conditions. The findings show that the action of phytate as a crystallization inhibitor takes place both in the intrapapillary tissue and urine.
authors.affiliation: Laboratory of Renal Lithiasis Research, University Institute of Health Sciences Research (IUNICS), University of Balearic Islands, Palma of Mallorca, Spain. fgrases@uib.es
authors.forename: Felix
authors.initials: F
authors.lastname: Grases
authors.forename: Bernat
authors.initials: B
authors.lastname: Isern
authors.forename: Pilar
authors.initials: P
authors.lastname: Sanchis
authors.forename: Joan
authors.initials: J
authors.lastname: Perello
authors.forename: Jose Juan
authors.initials: JJ
authors.lastname: Torres
authors.forename: Antonia
authors.initials: A
authors.lastname: Costa-Bauza
mesh_terms: D000818:Animals; D002118:Calcium / Q000032:analysis; D007668:Kidney / Q000737:chemistry / Q000473:pathology; D007669:Kidney Calculi / Q000473:pathology / Q000517:prevention & control* / Q000652:urine; D008297:Male; D010833:Phytic Acid / Q000627:therapeutic use* / Q000652:urine; D051381:Rats; D017208:Rats, Wistar
chemical_list: D010833:Phytic Acid; D002118:Calcium