title: [Parametric biomedical imaging--what defines the quality of quantitative radiological approaches?].
abstract: Quantitative parametric imaging approaches provide new perspectives for radiological imaging. These include quantitative 2D, 3D, and 4D visualization options along with the parametric depiction of biological tissue properties and tissue function. This allows the interpretation of radiological data from a biochemical, biomechanical, or physiological perspective. Quantification permits the detection of small changes that are not yet visually apparent, thus allowing application in early disease diagnosis and monitoring therapy with enhanced sensitivity. This review outlines the potential of quantitative parametric imaging methods and demonstrates this on the basis of a few exemplary applications. One field of particular interest, the use of these methods for investigational new drug application studies, is presented. Assessment criteria for judging the quality of quantitative imaging approaches are discussed in the context of the potential and the limitations of these methods. While quantitative parametric imaging methods do not replace but rather supplement established visual interpretation methods in radiology, they do open up new perspectives for diagnosis and prognosis and in particular for monitoring disease progression and therapy.
authors.affiliation: Medizinische Physik, Klinik für Diagnostische Radiologie, Universitätsklinikum Schleswig-Holstein, Kiel. glueer@rad.uni-kiel.de
authors.forename: C-C
authors.initials: CC
authors.lastname: Glüer
authors.forename: R
authors.initials: R
authors.lastname: Barkmann
authors.forename: H K
authors.initials: HK
authors.lastname: Hahn
authors.forename: S
authors.initials: S
authors.lastname: Majumdar
authors.forename: F
authors.initials: F
authors.lastname: Eckstein
authors.forename: T N
authors.initials: TN
authors.lastname: Nickelsen
authors.forename: H
authors.initials: H
authors.lastname: Bolte
authors.forename: V
authors.initials: V
authors.lastname: Dicken
authors.forename: M
authors.initials: M
authors.lastname: Heller
mesh_terms: D000465:Algorithms; D003287:Contrast Media; D003627:Data Interpretation, Statistical; D003951:Diagnostic Errors; D003952:Diagnostic Imaging / Q000379:methods* / Q000592:standards; D018450:Disease Progression; D020342:Finite Element Analysis; D005500:Follow-Up Studies; D006801:Humans; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional; D008279:Magnetic Resonance Imaging; D009369:Neoplasms / Q000098:blood supply / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000473:pathology; D010003:Osteoarthritis / Q000175:diagnosis; D010024:Osteoporosis / Q000175:diagnosis / Q000000981:diagnostic imaging; D049268:Positron-Emission Tomography; D017410:Practice Guidelines as Topic; D011379:Prognosis; D012016:Reference Values; D012680:Sensitivity and Specificity; D013997:Time Factors; D015899:Tomography, Emission-Computed, Single-Photon; D014057:Tomography, X-Ray Computed; D047368:Tumor Burden
chemical_list: D003287:Contrast Media