title: Paecilaminol, a new NADH-fumarate reductase inhibitor, produced by Paecilomyces sp. FKI-0550.
abstract: A new NADH-fumarate reductase inhibitor, paecilaminol, was isolated from the cultured broth of a fungus Paecilomyces sp. FKI-0550. It is an amino alcohol compound, the structure being established as 2-amino-14,16-dimethyl-3-octadecanol. Paecilaminol exhibited an IC50 value of 5.1 microM against Ascaris suum NADH-fumarate reductase.
authors.affiliation: Kitasato Institute for Life Sciences and Graduate School of Infection Control Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, Japan.
authors.forename: Hideaki
authors.initials: H
authors.lastname: Ui
authors.forename: Kazuro
authors.initials: K
authors.lastname: Shiomi
authors.forename: Hideaki
authors.initials: H
authors.lastname: Suzuki
authors.forename: Hiroko
authors.initials: H
authors.lastname: Hatano
authors.forename: Hiromi
authors.initials: H
authors.lastname: Morimoto
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Yamaguchi
authors.forename: Rokuro
authors.initials: R
authors.lastname: Masuma
authors.forename: Kimitoshi
authors.initials: K
authors.lastname: Sakamoto
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Kita
authors.forename: Hideto
authors.initials: H
authors.lastname: Miyoshi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Tomoda
authors.forename: Haruo
authors.initials: H
authors.lastname: Tanaka
authors.forename: Satoshi
authors.initials: S
authors.lastname: Omura
mesh_terms: D000473:Alkanes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000818:Animals; D000969:Antinematodal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D017165:Ascaris suum / Q000187:drug effects / Q000201:enzymology; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008055:Lipids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015394:Molecular Structure; D044925:Oxidoreductases Acting on CH-CH Group Donors / Q000037:antagonists & inhibitors*; D010143:Paecilomyces / Q000378:metabolism*; D021261:Parasitic Sensitivity Tests
chemical_list: D000473:Alkanes; D000969:Antinematodal Agents; D004791:Enzyme Inhibitors; D008055:Lipids; C515839:paecilaminol; D044925:Oxidoreductases Acting on CH-CH Group Donors; C020155:fumarate reductase (NADH)