Lipid rafts, detergent-resistant membranes, and raft targeting signals.
Lipid rafts are liquid-ordered (l(o)) phase microdomains proposed to exist in biological membranes. Rafts have been widely studied by isolating l(o)-phase detergent-resistant membranes (DRMs) from cells. Recent findings have shown that DRMs are not the same as preexisting rafts, prompting a major revision of the raft model. Nevertheless, raft-targeting signals identified by DRM analysis are often required for protein function, implicating rafts in a variety of cell processes.
Brown
Deborah A
DA
Department of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, New York, USA. deborah.brown@sunysb.edu
D000818:Animals; D002462:Cell Membrane / Q000502:physiology*; D003902:Detergents; D006801:Humans; D021962:Membrane Microdomains / Q000502:physiology*; D008565:Membrane Proteins / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*
D003902:Detergents; D008565:Membrane Proteins