Anti-ganglioside complex antibodies associated with severe disability in GBS.
Ganglioside complexes (GSCs) are known as target antigens in Guillain-Barré syndrome (GBS). To elucidate the clinical importance of the anti-GSC antibodies in GBS, we investigated serum antibodies to GSCs containing two of the gangliosides, GM1, GD1a, GD1b and GT1b, and analyzed clinical features of anti-GSC-positive GBS patients. Thirty-nine (17%) of 234 GBS patients had IgG anti-GSC antibodies. Anti-GSC-positive GBS had antecedent gastrointestinal infection and lower cranial nerve deficits more frequently than control GBS. The presence of antibody specificity to GD1a/GD1b and/or GD1b/GT1b was significantly associated with severe disability and a requirement for mechanical ventilation.
Kaida
K
K
Third Department of Internal Medicine, National Defense Medical College, 3-2 Namiki, Saitama-ken, 359-8513, Japan.
Morita
D
D
Kanzaki
M
M
Kamakura
K
K
Motoyoshi
K
K
Hirakawa
M
M
Kusunoki
S
S
D000328:Adult; D001323:Autoantibodies / Q000097:blood*; D002169:Campylobacter Infections / Q000150:complications; D016123:Campylobacter jejuni; D003389:Cranial Nerve Diseases / Q000150:complications; D004185:Disability Evaluation; D004594:Electrophysiology; D005260:Female; D005677:G(M1) Ganglioside / Q000031:analogs & derivatives / Q000276:immunology; D005732:Gangliosides / Q000276:immunology*; D005767:Gastrointestinal Diseases / Q000150:complications; D020275:Guillain-Barre Syndrome / Q000150:complications / Q000276:immunology / Q000503:physiopathology* / Q000628:therapy; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D007163:Immunosorbent Techniques; D008297:Male; D008875:Middle Aged; D012121:Respiration, Artificial; D012720:Severity of Illness Index
D001323:Autoantibodies; D005732:Gangliosides; D007074:Immunoglobulin G; C064020:ganglioside GD1alpha; C033851:ganglioside, GD1b; D005677:G(M1) Ganglioside; C016481:trisialoganglioside GT1