Ischemia and apoptosis in an animal model of permanent infarct-related artery occlusion.
Apoptosis is a pathologic feature of cardiomyocytes in acute myocardial infarction (AMI) and heart failure. The temporal course of apoptosis in the peri-infarct area in the weeks following an AMI is still uncompletely defined. In order to study the time course of apoptosis after AMI, 16 rabbits underwent left coronary artery ligation and were sacrificed at 16, 26, 35, and 56 days after surgery. Increased apoptotic rate (AR) was observed at in the peri-infarct region than in remote myocardium (5.4% [2.5-9.6] vs 0.4% [0.1-0.9], respectively, P<0.001) and than in sham-operated cases (0.01% [0-0.02], P<0.001). A gradual decrease of AR in the peri-infarct region was observed over time with a 90% reduction at 8 weeks after coronary ligation.
Abbate
Antonio
A
Morales
Celina
C
De Falco
Maria
M
Fedele
Valentina
V
Biondi Zoccai
Giuseppe G L
GG
Santini
Daniele
D
Palleiro
Jimena
J
Vasaturo
Fortunata
F
Scarpa
Susanna
S
Liuzzo
Giovanna
G
Severino
Anna
A
Baldi
Feliciano
F
Crea
Filippo
F
Biasucci
Luigi M
LM
Vetrovec
George W
GW
Gelpi
Ricardo J
RJ
Baldi
Alfonso
A
D000818:Animals; D017209:Apoptosis; D003327:Coronary Disease / Q000473:pathology*; D051546:Cyclooxygenase 2 / Q000378:metabolism; D004195:Disease Models, Animal; D005260:Female; D017202:Myocardial Ischemia / Q000473:pathology*; D009206:Myocardium / Q000473:pathology*; D032383:Myocytes, Cardiac / Q000378:metabolism / Q000473:pathology; D011817:Rabbits; D013997:Time Factors
D051546:Cyclooxygenase 2