An immunochemical approach to model and long-term suppression of depressive and anxiety behavior.
The inhibitor of monoaminooxydase isatin and the ligand of B-receptors cholecystokinin-4 play a significant role in the suppression and induction of depressive and anxiety states. We induced the formation of auto-antibodies to these compounds against their conjugates with antigen-carrier by immunization of white rats. The result was long-term (more than 2 months) stimulation of depressive and anxiety behavior after immunization to isatin and, in contrast, the suppression of such behavior after immunization to cholecystokinin. The perspective of immunochemical approach to long-term correction of behavior is discussed.
Ashmarin
Igor P
IP
Dept. of Human Physiology, School of Biology, Moscow State University, Vorobiovy Gory, Moscow 119922, Russia. ashmarin25@mail.ru
Danilova
Raisa A
RA
Rud'ko
Olga I
OI
Belopolskaya
Maria V
MV
Obukhova
Maria F
MF
Shmalgausen
Elena V
EV
D000818:Animals; D001007:Anxiety / Q000276:immunology* / Q000628:therapy; D001323:Autoantibodies / Q000097:blood*; D003863:Depression / Q000276:immunology* / Q000628:therapy; D018796:Immunoconjugates / Q000276:immunology; D007510:Isatin / Q000276:immunology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013758:Tetragastrin / Q000276:immunology*; D014611:Vaccination
D001323:Autoantibodies; D018796:Immunoconjugates; D013758:Tetragastrin; D007510:Isatin