Enhanced catalase-like activity of manganese salen complexes in water: effect of a three-dimensionally fixed auxiliary.
A new Mn(Salen) complex bearing an ureido group as an auxiliary that is three-dimensionally fixed by a cyclopentane ring fused to the Salen structure was developed. This compound exhibited considerably higher catalase-like activity than the original Mn(Salen), i.e., the cyclopentane-fused Mn(Salen) without the auxiliary, under near-physiological conditions.
Watanabe
Yoritada
Y
Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya, Japan.
Namba
Azusa
A
Umezawa
Naoki
N
Kawahata
Masatoshi
M
Yamaguchi
Kentaro
K
Higuchi
Tsunehiko
T
D002384:Catalysis; D018360:Crystallography, X-Ray; D003517:Cyclopentanes / Q000737:chemistry; D004789:Enzyme Activation; D005029:Ethylenediamines / Q000138:chemical synthesis / Q000737:chemistry*; D006860:Hydrogen Bonding; D006861:Hydrogen Peroxide / Q000737:chemistry; D008024:Ligands; D008958:Models, Molecular; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D013237:Stereoisomerism; D013997:Time Factors; D014508:Urea / Q000737:chemistry; D014867:Water / Q000737:chemistry
D003517:Cyclopentanes; D005029:Ethylenediamines; D008024:Ligands; D009942:Organometallic Compounds; D014867:Water; C090577:N,N'-bis(salicylideneamino)ethane-manganese(II); D014508:Urea; D006861:Hydrogen Peroxide