sICAM-1 in meningoencephalitis due to Angiostrongylus cantonensis.
BACKGROUND
Angiostrongylus cantonensis meningoencephalitis is an emergent disease in the Americas.


METHODS
Twelve children suffering from eosinophilic meningoencephalitis due to this parasite aged between 6-10 years were studied. Cerebrospinal fluid (CSF) and serum samples were taken simultaneously in the first diagnostic puncture at admission.


RESULTS
All cases showed typical findings on the routine CSF and serum analysis: increased CSF total protein, increased Q (CSF/serum) albumin accompanied by eosinophilia in CSF. No intrathecal synthesis of immunoglobulins was found. Mean serum and CSF sICAM-1 values were 337.4 and 3.97 ng/mL. Qalbumin and QsICAM-1 mean values were 4.1 and 6.2 respectively. In 50% of the patients an increased brain-derived fraction of sICAM-1 was found.


CONCLUSIONS
It may be suggested that a dynamic of the sICAM-1 brain derived fraction is perhaps associated to the immune response in the evolution of the disease.sICAM-1 may be an agent in negative feedback for eosinophils passage through the blood-CSF barrier into the inflammatory brain response.
Dorta-Contreras
Alberto Juan
AJ
Laboratorio Central Liquido Cefalorraquideo (LABCEL), Ciudad de La Habana, Cuba. adorta@infomed.sld.cu
Lewczuc
Piotr
P
Noris-García
Elena
E
Interián-Morales
María Teresa
MT
Magraner Tarrau
María Esther
ME
Padilla-Docal
Bárbara
B
Escobar-Pérez
Xiomara
X
D017185:Angiostrongylus cantonensis; D000818:Animals; D015415:Biomarkers / Q000097:blood / Q000134:cerebrospinal fluid; D016022:Case-Control Studies; D002648:Child; D004797:Enzyme-Linked Immunosorbent Assay; D004802:Eosinophilia / Q000097:blood / Q000134:cerebrospinal fluid / Q000469:parasitology*; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood* / Q000134:cerebrospinal fluid*; D008590:Meningoencephalitis / Q000097:blood / Q000134:cerebrospinal fluid / Q000469:parasitology*; D017206:Strongylida Infections / Q000097:blood / Q000134:cerebrospinal fluid / Q000469:parasitology
D015415:Biomarkers; D018799:Intercellular Adhesion Molecule-1