Positive correlation between standardized uptake values of FDG uptake in the stomach and the value of the C-13 urea breath test.
OBJECTIVE
The distribution of FDG uptake in the stomach is variable. Gastritis is one of the causes of elevated FDG uptake. Helicobacter pylori (HP) infection was found in approximately 80% of patients with peptic ulcer and 30% to 60% of symptomatic gastritis. The C-13 urea breath test (UBT) is one of the gold standard tools in diagnosis of HP infection. The aim of this study was to assess the correlation between standardized uptake values (SUVs) of FDG uptake in the stomach and the value of the C-13 urea breath test (UBT).


METHODS
Sixteen patients, referred from the department of community medicine, for FDG PET for health examination were chronologically enrolled for detection of HP infection by using the C-13 UBT within 1 week. The maximal SUVs of FDG uptake in the gastric wall as well as the value of the C-13 UBT were measured. The correlation between maximal SUVs of FDG uptake in the stomach and the value of the C-13 UBT was observed.


RESULTS
We took the results of C-13 UBT as the final diagnosis of HP infection. Of 16 patients, 5 were HP-infected and 11 were uninfected. Standardized uptake values of FDG uptake in the gastric wall were strong positively correlated with the value of the C-13 UBT in this retrospective study (P < 0.001).


CONCLUSIONS
Except for gastric cancer, HP infection has to be concerned when high SUVs of FDG uptake in the stomach are noted.
Lin
Chun-Yi
CY
Department of Nuclear Medicine and PET Center, China Medical University Hospital, Taichung, Taiwan.
Liu
Chiu-Shoung
CS
Ding
Hueisch-Jy
HJ
Sun
Shung-Shung
SS
Yen
Kuo-Yang
KY
Hsieh
Te-Chun
TC
Lin
Cheng-Chieh
CC
Kao
Chia-Hung
CH
D001944:Breath Tests / Q000379:methods; D002247:Carbon Isotopes; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000493:pharmacokinetics*; D005753:Gastric Mucosa / Q000378:metabolism; D005756:Gastritis / Q000175:diagnosis* / Q000378:metabolism*; D016481:Helicobacter Infections / Q000175:diagnosis* / Q000378:metabolism*; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D009928:Organ Specificity; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D013223:Statistics as Topic; D013270:Stomach / Q000000981:diagnostic imaging; D014508:Urea / Q000032:analysis
D002247:Carbon Isotopes; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D014508:Urea