title: Prediction of thrombolytic efficacy in acute ischemic stroke using thin-section noncontrast CT.
abstract: Thin-section noncontrast CT (NCT) can detect thrombi in large arteries and can provide a measure of thrombus composition based on Hounsfield Units (HU). A study using polyethylene tubes as a model of intracranial arteries concluded that the HUs of platelet-rich thrombi are lower than those of erythrocyte-rich thrombi. Thrombus HUs were measured by NCT in 34 patients with acute ischemic stroke before thrombolysis. Thrombi with lower HU counts were resistant to thrombolytics.
authors.affiliation: Department of Radiology and Research Institute of Radiological Sciences, Yonsei University College of Medicine, 134 Shinchon-dong, Seodaemun-gu, Seoul 120-752, Korea. eungykim@yumc.yonsei.ac.kr
authors.forename: E Y
authors.initials: EY
authors.lastname: Kim
authors.forename: J H
authors.initials: JH
authors.lastname: Heo
authors.forename: S-K
authors.initials: SK
authors.lastname: Lee
authors.forename: D J
authors.initials: DJ
authors.lastname: Kim
authors.forename: S-H
authors.initials: SH
authors.lastname: Suh
authors.forename: J
authors.initials: J
authors.lastname: Kim
authors.forename: D I
authors.initials: DI
authors.lastname: Kim
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001792:Blood Platelets / Q000000981:diagnostic imaging / Q000473:pathology; D002545:Brain Ischemia / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000503:physiopathology; D002536:Cerebral Arteries / Q000000981:diagnostic imaging* / Q000187:drug effects / Q000503:physiopathology; D004351:Drug Resistance / Q000502:physiology; D004912:Erythrocytes / Q000000981:diagnostic imaging / Q000473:pathology; D005260:Female; D005343:Fibrinolytic Agents / Q000009:adverse effects / Q000494:pharmacology*; D006801:Humans; D020767:Intracranial Thrombosis / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D018579:Patient Selection; D020959:Polyethylene; D011237:Predictive Value of Tests; D011300:Preoperative Care; D020521:Stroke / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000503:physiopathology; D010959:Tissue Plasminogen Activator / Q000009:adverse effects / Q000494:pharmacology; D014057:Tomography, X-Ray Computed / Q000379:methods* / Q000592:standards / Q000639:trends; D016896:Treatment Outcome
chemical_list: D005343:Fibrinolytic Agents; D020959:Polyethylene; D010959:Tissue Plasminogen Activator