title: Diffusion tensor imaging of frontal lobe white matter tracts in schizophrenia.
abstract: We acquired diffusion tensor and structural MRI images on 103 patients with schizophrenia and 41 age-matched normal controls. The vector data was used to trace tracts from a region of interest in the anterior limb of the internal capsule to the prefrontal cortex. Patients with schizophrenia had tract paths that were significantly shorter in length from the center of internal capsule to prefrontal white matter. These tracts, the anterior thalamic radiations, are important in frontal-striatal-thalamic pathways. These results are consistent with findings of smaller size of the anterior limb of the internal capsule in patients with schizophrenia, diffusion tensor anisotropy decreases in frontal white matter in schizophrenia and hypothesized disruption of the frontal-striatal-thalamic pathway system.
authors.affiliation: Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA. monte.buchsbaum@mssm.edu
authors.forename: Monte S
authors.initials: MS
authors.lastname: Buchsbaum
authors.forename: Peter
authors.initials: P
authors.lastname: Schoenknecht
authors.forename: Yuliya
authors.initials: Y
authors.lastname: Torosjan
authors.forename: Randall
authors.initials: R
authors.lastname: Newmark
authors.forename: King-Wai
authors.initials: KW
authors.lastname: Chu
authors.forename: Serge
authors.initials: S
authors.lastname: Mitelman
authors.forename: Adam M
authors.initials: AM
authors.lastname: Brickman
authors.forename: Lina
authors.initials: L
authors.lastname: Shihabuddin
authors.forename: M Mehmet
authors.initials: MM
authors.lastname: Haznedar
authors.forename: Erin A
authors.initials: EA
authors.lastname: Hazlett
authors.forename: Shabeer
authors.initials: S
authors.lastname: Ahmed
authors.forename: Cheuk
authors.initials: C
authors.lastname: Tang