Prenatal cortisol, prematurity and low birthweight.
Three hundred depressed pregnant women were recruited at approximately 20 weeks gestation. They were then divided by a median split into high and low urinary cortisol level groups. The high cortisol group had higher CES-D depression scores and higher inhibition (BIS) scores prenatally. Their fetuses had smaller head circumference, abdominal circumference, biparietal diameter and fetal weight. The high cortisol group neonates were shorter gestational age and lower birthweight and they had lower Brazelton habituation and higher Brazelton reflex scores. Discriminant function analyses suggested that cortisol levels more accurately classified short gestation and low birthweight groups than CES-D depression scores.
Field
Tiffany
T
Touch Research Institutes, University of Miami School of Medicine, Department of Pediatrics, FL 33101, USA. tfield@med.miami.edu
Hernandez-Reif
Maria
M
Diego
Miguel
M
Figueiredo
Barbara
B
Schanberg
Saul
S
Kuhn
Cynthia
C
D049628:Body Size; D001835:Body Weight; D003863:Depression / Q000097:blood / Q000523:psychology*; D005260:Female; D047109:Fetal Development / Q000502:physiology*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007234:Infant, Premature; D011237:Predictive Value of Tests; D011247:Pregnancy / Q000097:blood*; D011248:Pregnancy Complications / Q000523:psychology*
D006854:Hydrocortisone