Mutant presenilin 2 causes abnormality in the brain lipid profile in the development of Alzheimer's disease.
Mutation in the presenilin 2 (PS2mt) is known to be one of factors involved in the development of Alzheimer's disease (AD). It was recently revealed that an abnormality of lipid metabolism is a phenomenon occurring in AD. Therefore, the aim of this study was to investigate the potential relationship between the mutation of PS2 and alterations of the lipid profile within the brain. The results showed there increases in the levels of cholesterol, low density lipoprotein and triglyceride, but a decrease in the level of high density lipoprotein in brain tissues expressing mutant PS2. These findings indicated that PS2mt is involved in the abnormalities of the lipid profile, which could cause or result in the development of AD.
Nguyen
Hong Nga
HN
College of Pharmacy and CBITRC, Chungbuk National University, Cheongju 361-763, Korea.
Son
Dong Ju
DJ
Lee
Jae Woong
JW
Hwang
Dae Youn
DY
Kim
Young Kyu
YK
Cho
Jeong Sik
JS
Lee
Ung Soo
US
Yoo
Hwan Soo
HS
Moon
Dong Cheul
DC
Oh
Ki Wan
KW
Hong
Jin Tae
JT
D000367:Age Factors; D000544:Alzheimer Disease / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000378:metabolism*; D002784:Cholesterol / Q000378:metabolism*; D008076:Cholesterol, HDL / Q000378:metabolism; D008078:Cholesterol, LDL / Q000378:metabolism; D003124:Colorimetry / Q000379:methods; D050356:Lipid Metabolism; D008074:Lipoproteins / Q000378:metabolism*; D051379:Mice; D008822:Mice, Transgenic; D009154:Mutation / Q000235:genetics*; D053766:Presenilin-2 / Q000235:genetics*; D014280:Triglycerides / Q000378:metabolism
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008074:Lipoproteins; D053766:Presenilin-2; D014280:Triglycerides; D002784:Cholesterol