title: Scintigraphic imaging with a peptide glucuronide in rabbits: 99mTc- exorphin C glucuronide.
abstract: A peptide glucuronide (Exorphin C glucuronide) was labeled with 99mTc using glucoheptonate (GH) as a bifunctional chelating agent. Scintigraphic imaging was performed in male Albino rabbits. Exorphin C glucuronide showed rapid and efficient labeling with 99mTc using glucoheptonate as a bifunctional chelate. Results demonstrated that 99mTc-GEG may be a useful new type of glucuronide derivative of peptides for diagnosis of some cancer diseases.
authors.affiliation: Dokuz Eylül University, Medical School, Department of Nuclear Medicine, Inciralti, Turkey. turkan.ertay@deu.edu.tr
authors.forename: T
authors.initials: T
authors.lastname: Ertay
authors.forename: P
authors.initials: P
authors.lastname: Unak
authors.forename: F Z
authors.initials: FZ
authors.lastname: Biber
authors.forename: C
authors.initials: C
authors.lastname: Tasci
authors.forename: F
authors.initials: F
authors.lastname: Zihnioğlu
authors.forename: H
authors.initials: H
authors.lastname: Durak
mesh_terms: D000818:Animals; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism; D005260:Female; D020719:Glucuronides / Q000493:pharmacokinetics*; D006454:Hemoglobins / Q000493:pharmacokinetics*; D066298:In Vitro Techniques; D008297:Male; D008861:Microsomes / Q000378:metabolism; D008862:Microsomes, Liver / Q000378:metabolism; D015609:Organotechnetium Compounds / Q000493:pharmacokinetics*; D010446:Peptide Fragments / Q000493:pharmacokinetics*; D011817:Rabbits; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics*; D051381:Rats; D017208:Rats, Wistar; D011957:Receptors, Opioid / Q000378:metabolism*; D013400:Sugar Acids / Q000737:chemistry; D013667:Technetium; D014018:Tissue Distribution
chemical_list: D020719:Glucuronides; D006454:Hemoglobins; D015609:Organotechnetium Compounds; D010446:Peptide Fragments; D019275:Radiopharmaceuticals; D011957:Receptors, Opioid; D013400:Sugar Acids; C111722:exorphin C; C518966:technetium 99m exorphin C glucuronide; D013667:Technetium; C007852:alpha-glucoheptonic acid