Efficacy of concentrated autologous platelet-derived growth factors in chronic lower-extremity wounds.
The efficacy of concentrated autologous platelet-derived growth factors in the healing and closure of chronic lower-extremity wounds was evaluated in 24 patients with 33 lower-extremity wounds treated previously for at least 6 months using traditional methods. Surgical wound debridement was performed to convert chronic ulcers into acute wounds. Concentrated autologous platelet-derived growth factors and thrombin were applied to the wound bases and protected with a nonadhering compression dressing that remained intact for 7 days. Wounds were evaluated and the concentrate was reapplied every 2 weeks. Wound closure and complete epithelialization was achieved in 20 wounds. Seventy-five percent or greater wound closure was obtained in three wounds, 50% to 74% closure in three wounds, and 25% to 49% closure in two wounds. Five wounds displayed no improvement. Mean time to complete closure was 11.15 weeks. The application of concentrated autologous platelet-derived growth factors and thrombin resulted in substantial wound healing and wound-diameter reduction. This technique constitutes a safe and effective treatment option and avoids lengthy treatment periods that increase the potential for infection.
McAleer
Jody Peter
JP
Division of Podiatric Surgery, Department of Orthopaedics, Mount Sinai Hospital of Queens, Mount Sinai School of Medicine, Astoria, NY, USA.
Kaplan
Eric
E
Persich
Gianni
G
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003646:Debridement; D005260:Female; D006801:Humans; D007871:Leg Ulcer / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D010982:Platelet-Derived Growth Factor / Q000627:therapeutic use*; D012449:Safety; D016896:Treatment Outcome; D014945:Wound Healing / Q000187:drug effects*
D010982:Platelet-Derived Growth Factor