Pterocarpus santalinus: an In Vitro study on its anti-Helicobacter pylori effect.
The anti-H. pylori activity of Pterocarpus santalinus (PS), a traditional herb, has been assessed and compared with that of bismuth subcitrate, through in vitro studies employing rat gastric epithelial cell cultures and H. pylori isolates from gastric mucosal biopsy patients. The MIC of PS was found to be 20 microg/mL. H. pylori was co-cultivated with rat gastric epithelial cells in the presence/absence of PS at its MIC. A reduction in the activity of urease, a normal appearance of the epithelial cells on electron microscopic examination, a decrease in lipid peroxidation and lactate dehydrogenase suggests the possible anti-H. pylori activity of PS.
Narayan
Shoba
S
Department of Biochemistry, University of Madras, Guindy Campus, Chennai 600 025, India. shoba_narayan@rediffmail.com
Veeraraghavan
Mani
M
Devi
C S Shyamala
CS
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002478:Cells, Cultured; D004847:Epithelial Cells / Q000187:drug effects / Q000382:microbiology / Q000648:ultrastructure; D005753:Gastric Mucosa / Q000187:drug effects / Q000382:microbiology / Q000648:ultrastructure; D016480:Helicobacter pylori / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D046529:Microscopy, Electron, Transmission; D008871:Microvilli / Q000648:ultrastructure; D010936:Plant Extracts / Q000494:pharmacology*; D035721:Pterocarpus / Q000737:chemistry*; D051381:Rats
D000900:Anti-Bacterial Agents; D010936:Plant Extracts; C519377:Pterocarpus santalinus extract