[Pulmonary MALT lymphoma revealing AIDS].
BACKGROUND
We report the case of a patient with an isolated pulmonary mucosa associated lymphoid tissue (MALT) lymphoma that revealed an acquired immune deficiency syndrome (AIDS).


METHODS
A 30 year old man from Central Africa was admitted to hospital with cough, dyspnoea and general weakness. A diagnosis of HIV infection was made promptly. The thoracic CT scan revealed diffuse bilateral ground glass opacities as well as consolidation of the right upper lobe. After a non-diagnostic endoscopy the diagnosis of a low grade B cell MALT lymphoma (CD20+) was made by lung biopsy and confirmed by the presence of the t(11;18) translocation. No extrathoracic lymphoma was found. Treatment with rituximab and triple anti-retroviral therapy led to a rapid and complete remission that was maintained for 3 years after the diagnosis.


CONCLUSIONS
Pulmonary MALT lymphoma may reveal AIDS. A combination of rituximab and anti-retroviral therapy led to complete remission in this patient.
Cortot
A B
AB
Service de Pneumologie, Centre de référence des Maladies Orphelines Pulmonaires, Hôpital Louis Pradel, Université de Lyon - UMR 754, Lyon, France.
Cottin
V
V
Issartel
B
B
Meyronet
D
D
Coiffier
B
B
Cordier
J-F
JF
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy; D000328:Adult; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D058846:Antibodies, Monoclonal, Murine-Derived; D000970:Antineoplastic Agents / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active / Q000379:methods; D004359:Drug Therapy, Combination; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000821:virology*; D016483:Lymphoma, AIDS-Related / Q000175:diagnosis* / Q000188:drug therapy; D018442:Lymphoma, B-Cell, Marginal Zone / Q000175:diagnosis / Q000188:drug therapy / Q000821:virology*; D008297:Male; D000069283:Rituximab; D016896:Treatment Outcome
D000911:Antibodies, Monoclonal; D058846:Antibodies, Monoclonal, Murine-Derived; D000970:Antineoplastic Agents; D000069283:Rituximab