High levels of cervical HIV-1 RNA during early HIV-1 infection.
Few data are available on genital tract viral replication early after HIV-1 acquisition, when infectivity is high. We compared cervical HIV-1 RNA from 60 women with paired samples from within 90 days after HIV-1 acquisition and at viral setpoint (4-24 months). Cervical HIV-1 was higher in early compared with setpoint samples (mean 3.43 versus 2.85 log10 copies/swab, P < 0.001). After adjusting for HIV-1-plasma RNA, cervical HIV-1 RNA from 30 days or less after infection was increased by 0.45 log10 copies/swab (P = 0.006).
Lavreys
Ludo
L
Department of Epidemiology, University of Washington, Seattle, Washington, USA.
Baeten
Jared M
JM
Panteleeff
Dana D
DD
Richardson
Barbra A
BA
McClelland
R Scott
RS
Chohan
Varsha
V
Mandaliya
Kishorchandra
K
Ndinya-Achola
Jeckoniah O
JO
Overbaugh
Julie
J
D002584:Cervix Uteri / Q000821:virology*; D005260:Female; D015658:HIV Infections / Q000821:virology*; D015497:HIV-1 / Q000502:physiology*; D006801:Humans; D011446:Prospective Studies; D012367:RNA, Viral / Q000032:analysis* / Q000097:blood; D019562:Viral Load; D014779:Virus Replication / Q000502:physiology
D012367:RNA, Viral