title: Crystallographic protein model-building on the web.
abstract: X-ray crystallography is the most widely used method to determine the 3D structure of protein molecules. One of the most difficult steps in protein crystallography is model-building, which consists of constructing a backbone and then amino acid side chains into an electron density map. Interpretation of electron density maps represents a major bottleneck in protein structure determination pipelines, and thus, automated techniques to interpret maps can greatly improve the throughput. We have developed WebTex, a simple and yet powerful web interface to TEXTAL, a program that automates this process of fitting atoms into electron density maps. TEXTAL can also be downloaded for local installation.
  
  
  BACKGROUND
  Web interface, downloadable binaries and documentation at http://textal.tamu.edu
authors.affiliation: Department of Computer Science, Texas A&M University, 301 H.R. Bright Building, College Station, TX 77843-3112, USA. textal@tamu.edu
authors.forename: Kreshna
authors.initials: K
authors.lastname: Gopal
authors.forename: Erik
authors.initials: E
authors.lastname: McKee
authors.forename: Tod
authors.initials: T
authors.lastname: Romo
authors.forename: Reetal
authors.initials: R
authors.lastname: Pai
authors.forename: Jacob
authors.initials: J
authors.lastname: Smith
authors.forename: James
authors.initials: J
authors.lastname: Sacchettini
authors.forename: Thomas
authors.initials: T
authors.lastname: Ioerger
mesh_terms: D000465:Algorithms; D003198:Computer Simulation; D003461:Crystallography / Q000379:methods*; D020407:Internet; D008956:Models, Chemical; D008958:Models, Molecular; D011487:Protein Conformation; D011506:Proteins / Q000737:chemistry* / Q000648:ultrastructure*; D020539:Sequence Analysis, Protein / Q000379:methods; D012984:Software
chemical_list: D011506:Proteins