title: Development of the electroretinographic oscillatory potentials in normal and ROP rats.
abstract: OBJECTIVE
  To study the development of the electroretinographic (ERG) oscillatory potentials (OPs) in rats and to compare normal OPs with those in a rat model of retinopathy of prematurity (ROP).
  
  
  METHODS
  Following a longitudinal design, ERG responses to a greater than 5 log unit range of full-field stimuli were recorded in dark-adapted rats at postnatal day (P) 18, P31, P47, and P67. The ERG records were digitally filtered (60-235 Hz), and the trough-to-peak amplitudes and implicit times of OP2, OP3, OP4, and OP5 were measured. Additionally, rats with oxygen-induced retinopathy, a model of ROP, were studied at P31.
  
  
  RESULTS
  Generally, OP amplitude increased and implicit time decreased with increasing stimulus intensity. The shape of the stimulus-response functions changed with age. The amplitudes of OP2, OP3, and OP4 were largest at P31. OP5 was largest at P47. All OPs were significantly affected in ROP rats; OP5 was least affected by ROP.
  
  
  CONCLUSIONS
  A prolonged normal course of OP development, which featured waxing and waning of amplitudes, was observed and might have been consequent to maturation and then to final refinements of inner retinal circuitry. In ROP rats, marked attenuation of early OPs was consistent with persistent dysfunction of photoreceptors, and significant attenuation of the late OP5 was evidence of compromised function of inner retinal circuitry.
authors.affiliation: Department of Ophthalmology, Children's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: Kegao
authors.initials: K
authors.lastname: Liu
authors.forename: James D
authors.initials: JD
authors.lastname: Akula
authors.forename: Ronald M
authors.initials: RM
authors.lastname: Hansen
authors.forename: Anne
authors.initials: A
authors.lastname: Moskowitz
authors.forename: Michael S
authors.initials: MS
authors.lastname: Kleinman
authors.forename: Anne B
authors.initials: AB
authors.lastname: Fulton
mesh_terms: D000375:Aging / Q000502:physiology; D000818:Animals; D003623:Dark Adaptation; D004195:Disease Models, Animal; D004596:Electroretinography; D006801:Humans; D007231:Infant, Newborn; D009991:Oscillometry; D010100:Oxygen / Q000633:toxicity; D020419:Photoreceptor Cells, Vertebrate / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012165:Retinal Ganglion Cells / Q000502:physiology*; D012178:Retinopathy of Prematurity / Q000503:physiopathology*
chemical_list: D010100:Oxygen