title: Modelling epidermal homeostasis as an approach for clinical bioinformatics.
abstract: Modelling in systems biology currently lacks clinical applications. As a possible approach leading to clinical relevance the modelling of tissue homeostasis is proposed. As an example a model of epidermal homeostasis is presented which reproduces central morphological and kinetic characteristics of epidermal tissue. Each individual cell is modelled as an agent. The tissue arises as an emergent phenomenon from the interactions of agents. Each agent's behaviour is qualitatively modelled by a simple differentiation state-flow program. Epithelialisation under the influence of parameters concerning stem-cell location is briefly demonstrated.
authors.affiliation: Department of Medical Informatics, University Hospital Heidelberg, Germany. niels.grabe@med.uni-heidelberg.de
authors.forename: Niels
authors.initials: N
authors.lastname: Grabe
authors.forename: Thora
authors.initials: T
authors.lastname: Pommerencke
authors.forename: Dennis
authors.initials: D
authors.lastname: Müller
authors.forename: Simone
authors.initials: S
authors.lastname: Huber
authors.forename: Karsten
authors.initials: K
authors.lastname: Neuber
authors.forename: Hartmut
authors.initials: H
authors.lastname: Dickhaus
mesh_terms: D019295:Computational Biology; D005858:Germany; D006706:Homeostasis; D006801:Humans; D008954:Models, Biological; D012879:Skin Physiological Phenomena