title: Do mutations causing low HDL-C promote increased carotid intima-media thickness?
abstract: BACKGROUND
  Although observational data support an inverse relationship between high-density lipoprotein (HDL) cholesterol and coronary heart disease (CHD), genetic HDL deficiency states often do not correlate with premature CHD.
  
  
  METHODS
  Carotid intima-media thickness (cIMT) measurements were obtained in cases comprising 10 different mutations in LCAT, ABCA1 and APOA1 to further evaluate the relationship between low HDL resulting from genetic variation and early atherosclerosis.
  
  
  RESULTS
  In a 1:2 case-control study of sex and age-related (+/-5 y) subjects (n=114), cIMT was nearly identical between cases (0.66+/-0.17 cm) and controls (0.65+/-0.18 cm) despite significantly lower HDL cholesterol (0.67 vs. 1.58 mmol/l) and apolipoprotein A-I levels (96.7 vs. 151.4 mg/dl) (P<0.05)
  
  
  CONCLUSIONS
  Genetic variants identified in the present study may be insufficient to promote early carotid atherosclerosis.
authors.affiliation: University of Maryland Hospital and Veterans Affairs Medical Center, Baltimore, MD 21201, United States. mmiller@medicine.umaryland.edu
authors.forename: Michael
authors.initials: M
authors.lastname: Miller
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Rhyne
authors.forename: Seung Ho
authors.initials: SH
authors.lastname: Hong
authors.forename: Gina
authors.initials: G
authors.lastname: Friel
authors.forename: Christina
authors.initials: C
authors.lastname: Dolinar
authors.forename: Ward
authors.initials: W
authors.lastname: Riley
mesh_terms: D008076:Cholesterol, HDL / Q000097:blood*; D003287:Contrast Media; D003327:Coronary Disease / Q000097:blood* / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D009154:Mutation / Q000235:genetics; D012307:Risk Factors
chemical_list: D008076:Cholesterol, HDL; D003287:Contrast Media