First characterization of fluoroquinolone resistance in Streptococcus suis.
We have identified and sequenced the genes encoding the quinolone-resistance determining region (QRDR) of ParC and GyrA in fluoroquinolone-susceptible and -resistant Streptococcus suis clinical isolates. Resistance is the consequence of single point mutations in the QRDRs of ParC and GyrA and is not due to clonal spread of resistant strains or horizontal gene transfer with other bacteria.
Escudero
Jose Antonio
JA
Departamento de Sanidad Animal, Facultad de Veterinaria, Universidad Complutense de Madrid, 28040 Madrid, Spain.
San Millan
Alvaro
A
Catalan
Ana
A
de la Campa
Adela G
AG
Rivero
Estefania
E
Lopez
Gema
G
Dominguez
Lucas
L
Moreno
Miguel Angel
MA
Gonzalez-Zorn
Bruno
B
D000595:Amino Acid Sequence; D027081:DNA Gyrase / Q000235:genetics; D027101:DNA Topoisomerase IV / Q000235:genetics; D024881:Drug Resistance, Bacterial / Q000235:genetics; D005260:Female; D024841:Fluoroquinolones / Q000494:pharmacology*; D005798:Genes, Bacterial; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D017354:Point Mutation; D012336:RNA, Ribosomal, 16S / Q000235:genetics; D016415:Sequence Alignment; D017011:Streptococcus suis / Q000187:drug effects / Q000235:genetics
D024841:Fluoroquinolones; D012336:RNA, Ribosomal, 16S; D027101:DNA Topoisomerase IV; D027081:DNA Gyrase