title: [Longitudinal study of three families with familial Parkinson's disease].
abstract: BACKGROUND
  Familial Parkinson's is a variant of Parkinson's disease (PD) transmitted generationally with an early onset.
  
  
  OBJECTIVE
  Describe the clinical disease characteristics and its 18 year evolution among families in Colima presenting familial PD.
  
  
  METHODS
  We determined disease diagnosis, evolution and hereditary pattern. The UPDRS system was used to follow the longitudinal course of the disease. Descriptive statistics were carried out using means and percentages.
  
  
  RESULTS
  Three families were studied, with a total of 51 subjects aged 29 +/- 22 years spanning 4 generations. Thirty-seven percent of studied subjects displayed familial PD, with disease onset at 24 +/- 9 years of age. The highest UPDRS value was 175. Disease transmission with a dominant autosomic heredity pattern was shown. One hundred percent of first and second generation members from family number 1 displayed the disease.
  
  
  CONCLUSIONS
  The three families displayed early onset PD and rapid progression, coinciding with described characteristics of type 1 familial Parkinsonism (PARK1). This disease is caused by the Ala53Thr mutation of the alpha-synuclein gene.
authors.affiliation: Laboratorio de Genética, Centro Universitario de Investigaciones Biomédicas, Facultad de Medicina, Universidad de Colima, Colima, Col., México.
authors.forename: Luz Margarita
authors.initials: LM
authors.lastname: Baltasar-Rodríguez
authors.forename: Rebeca O
authors.initials: RO
authors.lastname: Millán-Guerrero
authors.forename: Roberto
authors.initials: R
authors.lastname: Aceves-Themsel
authors.forename: Sara
authors.initials: S
authors.lastname: Isais-Millán
authors.forename: Iván
authors.initials: I
authors.lastname: Delgado-Enciso
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D018450:Disease Progression; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D015994:Incidence; D008137:Longitudinal Studies; D008297:Male; D008800:Mexico / Q000453:epidemiology; D008875:Middle Aged; D010300:Parkinson Disease / Q000097:blood / Q000453:epidemiology / Q000235:genetics*; D010375:Pedigree; D012720:Severity of Illness Index; D017678:Sex Distribution