Effect of the immunomodulator leflunomide on the induction of endometriosis in an experimental rat model.
The effect of immunomodulator leflunomide on the development of an experimental endometriosis model was assessed by surgically transplanting autologous fragments of endometrial tissue onto the inner surface of the abdominal wall and arterial cascades of the small intestines. Leflunomide was found to affect the development of endometriosis negatively and seemed to interfere with the growth and maintenance of the uterine explant in this experimental rat model.
Aytan
Hakan
H
Caglar
Pinar
P
Uygur
Dilek
D
Zergeroglu
Sema
S
Batioglu
Sertac
S
D000818:Animals; D004195:Disease Models, Animal; D004715:Endometriosis / Q000473:pathology / Q000517:prevention & control*; D005260:Female; D007155:Immunologic Factors / Q000494:pharmacology*; D007555:Isoxazoles / Q000494:pharmacology*; D000077339:Leflunomide; D051381:Rats; D014599:Uterus / Q000637:transplantation
D007155:Immunologic Factors; D007555:Isoxazoles; D000077339:Leflunomide