A new gamma-lactone from the leaves of Cinnamomum kotoense.
A new C19 gamma-lactone, cinnakotolactone (1), along with a known analogue, isolinderanolide B (2), were isolated from the n-hexane layer of the leaf extracts of Cinnamomum kotoense. Their structures were elucidated on the basis of spectroscopic analysis. The anti-proliferation activities of 1 and 2 were evaluated against human HT29 and MCF-7 cancer cell lines, and their IC50 values ranged from 3.3 +/- 0.3 to 25.8 +/- 5.3 microM.
Yang
Sien-Sing
SS
Department of Internal Medicine, Cathy General Hospital, Taipei 106, Taiwan, ROC.
Hou
Wen-Chi
WC
Huang
Li-Wei
LW
Lee
Tzong-Huei
TH
D049109:Cell Proliferation / Q000187:drug effects; D027424:Cinnamomum / Q000737:chemistry*; D003603:Cytotoxins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019073:HT29 Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019906:Nuclear Magnetic Resonance, Biomolecular; D009904:Optical Rotation; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013055:Spectrophotometry, Infrared; D013624:Taiwan
D003603:Cytotoxins; D007783:Lactones; D010936:Plant Extracts