title: Stability of and inflammatory response to silicon coated with a fluoroalkyl self-assembled monolayer in the central nervous system.
abstract: A self-assembled monolayer (SAM) of fluoroalkyl silane (FAS) (CF(3)(CF(2))(5)(CH(2))(2)SiCl(3)) was deposited on the surface of silicon wafers, aiming to enhance its stability and to reduce the inflammatory response in the central nervous system. Following implantation of the FAS SAM coated silicon in rat brains, the FAS SAM coating failed to reduce the inflammatory response of silicon, because it could not prevent the corrosion of the underlying silicon. The corrosion was hindered for the initial 10 days by the FAS SAM coating, but there was nearly no difference when compared to the uncoated silicon when the implantation periods were extended to 28 and 90 days. The FAS SAM coating was completely removed within 28 and 90 days. Meanwhile, on all the extracted uncoated and FAS SAM coated silicon wafers, there were proteinaceous substances deposited on the surfaces, and the amount of the deposits increased with exposure time.
authors.affiliation: Department of Chemical Engineering and Materials Science, Wayne State University, 5050 Anthony Wayne Drive, Detroit, Michigan 48202, USA.
authors.forename: Anfeng
authors.initials: A
authors.lastname: Wang
authors.forename: Xuemei
authors.initials: X
authors.lastname: Liang
authors.forename: James P
authors.initials: JP
authors.lastname: McAllister
authors.forename: Jie
authors.initials: J
authors.lastname: Li
authors.forename: Kelley
authors.initials: K
authors.lastname: Brabant
authors.forename: Carolyn
authors.initials: C
authors.lastname: Black
authors.forename: Paul
authors.initials: P
authors.lastname: Finlayson
authors.forename: Ting
authors.initials: T
authors.lastname: Cao
authors.forename: Haiying
authors.initials: H
authors.lastname: Tang
authors.forename: Steven O
authors.initials: SO
authors.lastname: Salley
authors.forename: Gregory W
authors.initials: GW
authors.lastname: Auner
authors.forename: K Y
authors.initials: KY
authors.lastname: Simon Ng
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry* / Q000633:toxicity; D001921:Brain / Q000187:drug effects / Q000378:metabolism / Q000473:pathology / Q000601:surgery*; D020099:Coated Materials, Biocompatible / Q000737:chemistry; D003343:Corrosion; D004355:Drug Stability; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D007249:Inflammation / Q000209:etiology / Q000473:pathology; D008422:Materials Testing; D009410:Nerve Degeneration / Q000209:etiology / Q000378:metabolism / Q000473:pathology; D019736:Prostheses and Implants; D051381:Rats; D017207:Rats, Sprague-Dawley; D012821:Silanes / Q000737:chemistry* / Q000633:toxicity; D013499:Surface Properties
chemical_list: D001672:Biocompatible Materials; D020099:Coated Materials, Biocompatible; D005904:Glial Fibrillary Acidic Protein; D012821:Silanes