Freeze-drying of nanoparticles: formulation, process and storage considerations.
Freeze-drying has been considered as a good technique to improve the long-term stability of colloidal nanoparticles. The poor stability in an aqueous medium of these systems forms a real barrier against the clinical use of nanoparticles. This article reviews the state of the art of freeze-drying nanoparticles. It discusses the most important parameters that influence the success of freeze-drying of these fragile systems, and provides an overview of nanoparticles freeze-drying process and formulation strategies with a focus on the impact of formulation and process on particle stability.
Abdelwahed
Wassim
W
Laboratoire d'Automatique et de Génie des Procédés (LAGEP) UMR-CNRS 5007 CPE Lyon, ISPB, Université Claude Bernard Lyon 1, 43, Boulevard du 11 Novembre 1918, 69622 Villeurbanne cedex, France.
Degobert
Ghania
G
Stainmesse
Serge
S
Fessi
Hatem
H
D055598:Chemical Phenomena; D002626:Chemistry, Pharmaceutical; D002627:Chemistry, Physical; D004356:Drug Storage; D005612:Freeze Drying; D053758:Nanoparticles / Q000737:chemistry*