The first infant case with hepatosplenic gammadelta T-cell lymphoma after acute disseminated encephalomyelitis (ADEM)-like exacerbation.
We report the first infant case with hepatosplenic gammadelta T-cell lymphoma after recurrent acute disseminated encephalomyelitis-like, which were rapidly resolved with steroid pulse therapy. The patient had a history of recurrent bronchitis, intractable diarrhea, and failure to thrive since 4 months of age. Immunologic analysis revealed higher percentage of circulating gammadelta T-cells with markedly reduced numbers of CD3TCRalphabetaCD8 T-cells. The patient developed gammadelta T-cell lymphoma at the age of 15 months. Clinical course of the patient suggests the importance of immunological background for the development of hepatosplenic gammadelta T-cell lymphoma.
Koga
Shinichiro Y
SY
Department of Pediatrics, School of Medicine, Tohoku University Hospital, Tohoku University, Sendai, Japan.
Kumaki
Satoru
S
Ichinohasama
Ryo
R
Munakata
Mitsutoshi
M
Haginoya
Kazuhiro
K
Ohashi
Yoshiyuki
Y
Tanaka
Yoshiko
Y
Sakamoto
Osamu
O
Minegishi
Masayoshi
M
Morio
Tomohiro
T
Iinuma
Kazuie
K
Tsuchiya
Shigeru
S
D004673:Encephalomyelitis, Acute Disseminated / Q000150:complications* / Q000473:pathology; D006801:Humans; D007223:Infant; D008113:Liver Neoplasms / Q000150:complications*; D016399:Lymphoma, T-Cell / Q000150:complications* / Q000276:immunology; D008279:Magnetic Resonance Imaging; D008297:Male; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000032:analysis*; D013160:Splenic Neoplasms
D016692:Receptors, Antigen, T-Cell, gamma-delta