title: Reaching the population with dementia drugs: what are the challenges?
abstract: BACKGROUND
  Systematic evidence became available in the late 1990s on efficacy of cholinesterase inhibitors (CHEIs) for patients with mild to moderate Alzheimer's disease (AD) and they began to be used sporadically. Since January 2001 UK based guidelines indicated that one of three cholinesterase inhibitors (CHEIs) could be prescribed for these patients. Since then the cost of prescription in England and Wales has risen. There has been little investigation of uptake at the population level.
  
  
  OBJECTIVE
  To estimate the population uptake of CHEIs in a population based study of dementia spanning this period.
  
  
  METHODS
  Using data from a 10-year follow up and a later 12 year interview of the Medical Research Council Cognitive Function and Ageing Study (MRC CFAS), a UK population based longitudinal cohort study of people originally aged 65 years and above, we investigated who was taking CHEIs during the period 2001-2004. We sought information from respondents taking part in the study what medication they were taking on a regular basis.
  
  
  RESULTS
  Only 12, of the 219 individuals who received a study diagnosis of dementia were prescribed CHEIs [5%, 95% Confidence Intervals (CI) 3%-9%]) in 2001/2003 and none of the 28 individuals with a study diagnosis of dementia (0%, 95% CI 0-18%) in 2004 were prescribed CHEIs. Uptake was biased towards individuals with more education and higher social class.
  
  
  CONCLUSIONS
  These data suggest that any impact on AD progression at the population level will be negligible as prescription of CHEIs and uptake in the age group at highest risk is so limited. There is little evidence that this has changed over time.
authors.affiliation: MRC Biostatistics Unit, Institute of Public Health, Cambridge, UK. Fiona.mattews@mrc-bsu.cam.ac.uk
authors.forename: Fiona E
authors.initials: FE
authors.lastname: Matthews
authors.forename: Ian
authors.initials: I
authors.lastname: McKeith
authors.forename: John
authors.initials: J
authors.lastname: Bond
authors.forename: Carol
authors.initials: C
authors.lastname: Brayne
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000188:drug therapy* / Q000191:economics; D002800:Cholinesterase Inhibitors / Q000191:economics / Q000627:therapeutic use*; D015331:Cohort Studies; D003363:Cost Control; D011307:Drug Prescriptions / Q000706:statistics & numerical data; D004363:Drug Utilization / Q000592:standards; D005260:Female; D006306:Health Surveys; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008609:Mental Status Schedule; D018697:Nootropic Agents / Q000191:economics / Q000627:therapeutic use*; D013222:State Medicine / Q000191:economics; D006113:United Kingdom
chemical_list: D002800:Cholinesterase Inhibitors; D018697:Nootropic Agents