title: [Central vein occlusion in a patient using interferon and ribavirin: case report].
abstract: Interferon and ribavirin are medications widely used in the treatment of some systemic diseases, mainly hepatitis C. Ribavirin when associated with interferon increases the rate of success of this treatment. There are about 170 million patients with chronic hepatitis C in the world, many in use of these medications. The classic associated retinopathy is described as cotton wool exudates and hemorrhages. Since the first reports, several different ocular disturbances were described in association with interferon. The present case shows a patient whose right eye presented with central retinal vein occlusion and whose left eye presented the typical findings of hemorrhages; prompt resolution after the medications were discontinued.
authors.affiliation: Serviço de Oftalmologia, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brasil.
authors.forename: John
authors.initials: J
authors.lastname: Helal
authors.forename: Leandro Cabral
authors.initials: LC
authors.lastname: Zacharias
authors.forename: Luciana Malta
authors.initials: LM
authors.lastname: de Alencar
mesh_terms: D000998:Antiviral Agents / Q000009:adverse effects*; D004359:Drug Therapy, Combination; D005260:Female; D019698:Hepatitis C, Chronic / Q000188:drug therapy; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000009:adverse effects*; D008875:Middle Aged; D011994:Recombinant Proteins; D012166:Retinal Hemorrhage / Q000139:chemically induced* / Q000175:diagnosis; D012170:Retinal Vein Occlusion / Q000139:chemically induced* / Q000175:diagnosis; D012254:Ribavirin / Q000009:adverse effects*
chemical_list: D000998:Antiviral Agents; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; D012254:Ribavirin