title: Antimicrobial activity and composition of the essential oil of Gontscharovia popovii from Iran.
abstract: The aerial parts of Gontscharovia popovii (B. Fedtsch. and Gontsch.) Boriss. were collected at full flowering stage. The essential oil was isolated by hydrodistillation and analyzed by a combination of capillary GC and GC-MS. Thirty-one components were identified with the main constituent being carvacrol (71.9%), followed by linalool (5.5%), p-cymene (4.5%) and gamma-terpinene (4.4%). The in vitro antimicrobial activity of the essential oil of G. popovii was studied against seven Gram-positive and Gram-negative bacteria (Bacillus subtilis, Enterococcus faecalis, Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Pseudomonas aeruginosa and Klebsiella pneumoniae) and three fungi (Candida albicans, Saccharomyces cerevisiae and Aspergillus niger). The results of the bioassays showed that the oil exhibited strong antimicrobial activity against all the tested fungi and bacteria except for the resistant bacterium Pseudomonas aeruginosa.
authors.affiliation: Department of Biology, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, Evin, P.O. Box 19835-389, Tehran, Iran. a-sonboli@sbu.ac.ir
authors.forename: Ali
authors.initials: A
authors.lastname: Sonboli
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Sefidkon
authors.forename: Morteza
authors.initials: M
authors.lastname: Yousefzadi
mesh_terms: D000080462:Acyclic Monoterpenes; D000900:Anti-Bacterial Agents / Q000302:isolation & purification* / Q000494:pharmacology; D000935:Antifungal Agents / Q000302:isolation & purification* / Q000494:pharmacology; D002849:Chromatography, Gas; D000081005:Cyclohexane Monoterpenes; D000081007:Cymenes; D005658:Fungi / Q000187:drug effects; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D007492:Iran; D019686:Lamiaceae / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D039821:Monoterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D009822:Oils, Volatile / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000080462:Acyclic Monoterpenes; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D000081005:Cyclohexane Monoterpenes; D000081007:Cymenes; D039821:Monoterpenes; D009822:Oils, Volatile; C018669:gamma-terpinene; C073316:carvacrol; C018584:linalool