title: Drosophila aging 2005/06.
abstract: Drosophila continues to be a model system of choice to study the genetics of aging. It has a short lifespan and small genome size, but nevertheless contains a complex organ and endocrine system that allows studying the role of conserved signal transduction pathways with sophisticated genetic tools. Oxidative stress and metabolic changes along with intersecting signaling systems Insulin Receptor (InR), Target of Rapamycin (TOR) and Jun N-terminal Kinase (JNK) have emerged as some of the major players in aging. Sleep and organ-specific aging has also been the subject of recent progress in understanding aging.
authors.affiliation: Centre for Neuroscience and Aging, The Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.
authors.forename: Hui-Ying
authors.initials: HY
authors.lastname: Lim
authors.forename: Rolf
authors.initials: R
authors.lastname: Bodmer
authors.forename: Laurent
authors.initials: L
authors.lastname: Perrin
mesh_terms: D000375:Aging / Q000235:genetics*; D000818:Animals; D004330:Drosophila / Q000235:genetics*; D029721:Drosophila Proteins / Q000235:genetics; D006321:Heart / Q000502:physiology; D006801:Humans; D008136:Longevity / Q000235:genetics; D008928:Mitochondria / Q000235:genetics; D023421:Models, Animal; D018384:Oxidative Stress / Q000235:genetics; D019869:Phosphatidylinositol 3-Kinases / Q000235:genetics; D011494:Protein Kinases; D011972:Receptor, Insulin / Q000235:genetics; D012890:Sleep / Q000235:genetics; D013234:Stem Cells / Q000502:physiology; D058570:TOR Serine-Threonine Kinases
chemical_list: D029721:Drosophila Proteins; D019869:Phosphatidylinositol 3-Kinases; D011494:Protein Kinases; D011972:Receptor, Insulin; D058570:TOR Serine-Threonine Kinases; C416303:target of rapamycin protein, Drosophila