Xanthones from Garcinia mangostana (Guttiferae).
Studies on the stem of Garcinia mangostana have led to the isolation of one new xanthone mangosharin (1) (2,6-dihydroxy-8-methoxy-5-(3-methylbut-2-enyl)-xanthone) and six other prenylated xanthones, alpha-mangostin (2), beta-mangostin (3), garcinone D (4), 1,6-dihydroxy-3,7-dimethoxy-2-(3-methylbut-2-enyl)-xanthone (5), mangostanol (6) and 5,9-dihydroxy-8- methoxy-2,2-dimethyl-7-(3-methylbut-2-enyl)-2H,6H-pyrano-[3,2-b]-xanthene-6-one (7). The structures of these compounds were determined by spectroscopic methods such as 1H NMR, 13C NMR, mass spectrometry (MS) and by comparison with previous studies. All the crude extracts when screened for their larvicidal activities indicated very good toxicity against the larvae of Aedes aegypti. This article reports the isolation and identification of the above compounds as well as bioassay data for the crude extracts. These bioassay data have not been reported before.
Ee
G C L
GC
Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia. gwen@fsas.upm.edu.my
Daud
S
S
Taufiq-Yap
Y H
YH
Ismail
N H
NH
Rahmani
M
M
D000330:Aedes / Q000187:drug effects; D000818:Animals; D001681:Biological Assay; D029760:Garcinia / Q000737:chemistry*; D007814:Larva / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000633:toxicity; D018547:Plant Stems / Q000737:chemistry*; D014118:Toxins, Biological / Q000737:chemistry / Q000633:toxicity; D044004:Xanthones / Q000737:chemistry* / Q000302:isolation & purification
C518341:2,6-dihydroxy-8-methoxy-5-(3-methylbut-2-enyl)xanthone; D010936:Plant Extracts; D014118:Toxins, Biological; D044004:Xanthones