Preparation and biological studies of 125I-DOTA-TATE.
DOTA-TATE, a somatostatin analog was radiolabeled with (125)I in good yields and high radiochemical purity. The product exhibited good stability in vitro. Pharmacokinetic studies in normal Swiss mice showed rapid blood clearance with low thyroid uptake. Biodistribution studies in murine melanoma showed 3.0+/-1.3% ID/g uptake in tumor at 3h post injection (p.i.), with negligible reduction at 24h p.i. Inhibition studies carried out in vivo using cold DOTA-TATE confirmed the tumor specificity of the product.
Korde
Aruna
A
Radiopharmaceuticals Division, Bhabha Atomic Research Centre, Mumbai 400 085, India.
Pandey
Usha
U
Banerjee
Sharmila
S
Dev Sarma
Haladhar
H
Mukherjee
Archana
A
Venkatesh
Meera
M
D000818:Animals; D004355:Drug Stability; D066298:In Vitro Techniques; D007457:Iodine Radioisotopes / Q000737:chemistry* / Q000493:pharmacokinetics; D008546:Melanoma, Experimental / Q000000981:diagnostic imaging; D051379:Mice; D008810:Mice, Inbred C57BL; D015282:Octreotide / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000493:pharmacokinetics; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D014018:Tissue Distribution
D007457:Iodine Radioisotopes; D019275:Radiopharmaceuticals; D015282:Octreotide