Diesel exhaust and coal mine dust: lung cancer risk in occupational settings.
Conflicting evidence on the carcinogenicity of diesel exhaust (DE) and coal mine dust in occupational settings exist. Exposure measurement in most studies is inferred on the basis of job classifications and may lead to misclassification. Confounding behavioral factors (i.e., smoking) and occupational risk factors (exposure to asbestos, arsenic, radon) need to be considered. We evaluated the epidemiological evidence and current findings of the carcinogenicity of DE and coal mine dust in occupational settings. Pertaining literature was identified through Medline search and recent review articles. Strengths and limitations of recent approaches are discussed. Many epidemiological studies have addressed the question of carcinogenicity in workers exposed to DE, and most showed a low-to-medium increase in the risk of bronchial carcinoma. The pooled relative risk (RR) estimates lie between 1.33 and 1.47, and a consistent rise in risk across various job categories and study designs point to a causal relationship. Data on the carcinogenicity of coal mine dust are less consistent and the potential for confounding by unmeasured risk factors (arsenic, radon, DE) are higher. While silica as one of its components has been evaluated as carcinogenic, there is inadequate evidence for the carcinogenicity of pure coal dust according to the International Agency for Research on Cancer (IARC). There is sufficient evidence for a causal relationship between DE and lung cancer in occupational settings. The evidence for coal mine dust is less convincing, but individual studies show an increase in risk of lung cancer in exposed workers.
Hoffmann
Barbara
B
Institute for Medical Informatics, Biometry and Epidemiology, University Clinics of Essen, Hufelandstr. 55, 45122 Essen, Germany. Barbara.Hoffmann@medizin.uni-essen.de
Jöckel
Karl-Heinz
KH
D000818:Animals; D016022:Case-Control Studies; D003032:Coal Mining; D004391:Dust; D006801:Humans; D008175:Lung Neoplasms / Q000453:epidemiology*; D016273:Occupational Exposure; D001335:Vehicle Emissions
D004391:Dust; D001335:Vehicle Emissions