New synthetic protocols for the preparation of unsymmetrical bisindoles.
Novel unsymmetrical bisindoles were synthesized by a solvent-free C-C bond-formation reaction under mild conditions. Starting from aziridines or hydroxyl precursors, indoles have been used as C-nucleophiles to form new pharmacologically interesting bisindoles via an electrophilic aromatic substitution pathway in good to excellent yields. [reaction: see text]
Kaiser
Hanns Martin
HM
Leibniz-Institut für Katalyse e.V. an der Universität Rostock, Albert-Einstein-Strasse 29a, D-18059 Rostock, Germany.
Lo
Wei Fun
WF
Riahi
Abdol Majid
AM
Spannenberg
Anke
A
Beller
Matthias
M
Tse
Man Kin
MK
D001388:Aziridines / Q000737:chemistry; D002384:Catalysis; D003460:Crystallization; D018360:Crystallography, X-Ray; D017665:Hydroxyl Radical; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D019311:Staurosporine / Q000737:chemistry
D001388:Aziridines; D007211:Indoles; D017665:Hydroxyl Radical; D019311:Staurosporine