[Somnolence of unknown origin--illness or drug problem?].
A 64 year old female patient with previously known temporal lobe epilepsy (TLE) was admitted to the emergency department (ED) for further investigation of somnolence of unknown origin. Differential diagnosis remained puzzling after exclusion of an intracranial process and status epilepticus. Quantitative and qualitative fluctuations of consciousness are well known to take place in TLE as well as that these patients often are receiving several drugs for their illness. Drug history and measuring serum drug levels are helpful. Adverse Drug Events (ADE) are not rare in EDs: approximately 5% of ED patients are suffering an ADE and about 3% of patients admitted to hospitals are admitted because of an ADE. It is important to realize that three out of four ADEs are estimated to be preventable.
Hug
B L
BL
Medizinische Klinik B, Universitätsspital Basel. bhug@uhbs.ch
D000927:Anticonvulsants / Q000009:adverse effects* / Q000627:therapeutic use; D002220:Carbamazepine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D003937:Diagnosis, Differential; D006970:Disorders of Excessive Somnolence / Q000139:chemically induced* / Q000175:diagnosis; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D004833:Epilepsy, Temporal Lobe / Q000188:drug therapy*; D005260:Female; D006801:Humans; D000077213:Lamotrigine; D008140:Lorazepam / Q000009:adverse effects* / Q000627:therapeutic use; D008875:Middle Aged; D000078330:Oxcarbazepine; D011618:Psychotic Disorders / Q000188:drug therapy*; D014227:Triazines / Q000009:adverse effects* / Q000627:therapeutic use
D000927:Anticonvulsants; D014227:Triazines; D002220:Carbamazepine; D008140:Lorazepam; D000077213:Lamotrigine; D000078330:Oxcarbazepine