title: Prevention of gynaecological adhesions using haemostatic fleece in a rabbit model.
abstract: This pre-clinical study was performed to investigate the ability of the haemostatic fleece TachoComb to prevent adhesion formation following uterine surgery. Thirty rabbits were randomized to receive TachoComb or no intervention following incision to the right uterine horn. After 14 days, the animals were killed and examined for the presence of adhesion. The lengths of any adhesions were measured and the severity was recorded as a score (0, no adhesion; 1, adhesion easy to lyse; 2, adhesion lysed with traction; 3, adhesion separated by sharp dissection). The incidence of adhesions was 100% in the control group compared with 33% in the TachoComb-treated animals. The mean adhesion score was significantly lower (0.7 versus 2.2) and the mean adhesion length category was significantly shorter (0.4 versus 2.0) with TachoComb than in the control group. This study indicates that TachoComb is a well-tolerated and effective means of preventing adhesion following gynaecological surgery.
authors.affiliation: ZLB Behring GmbH, Marburg, Germany. Gerhard.Dickneite@zlbbehring.com
authors.forename: G
authors.initials: G
authors.lastname: Dickneite
authors.forename: U
authors.initials: U
authors.lastname: Rolle
authors.forename: D
authors.initials: D
authors.lastname: Rosenthal
mesh_terms: D000818:Animals; D007611:Aprotinin / Q000627:therapeutic use*; D004338:Drug Combinations; D005260:Female; D005340:Fibrinogen / Q000627:therapeutic use*; D013509:Gynecologic Surgical Procedures / Q000009:adverse effects* / Q000379:methods*; D006488:Hemostasis, Surgical / Q000379:methods*; D023421:Models, Animal; D011817:Rabbits; D013917:Thrombin / Q000627:therapeutic use*; D000267:Tissue Adhesions / Q000517:prevention & control*; D016896:Treatment Outcome; D014599:Uterus / Q000601:surgery*
chemical_list: D004338:Drug Combinations; C093991:tachocomb; D005340:Fibrinogen; D007611:Aprotinin; D013917:Thrombin