Bohemamines from a marine-derived Streptomyces sp.
Investigation of the culture extracts of a marine-derived Streptomyces sp. led to the isolation of three new bohemamine-type pyrrolizidine alkaloids, bohemamine B (1), bohemamine C (2), and 5-chlorobohemamine C (3). The structures were elucidated using NMR methods, and the relative stereochemistry was determined using double-pulsed-field-gradient spin echo (DPFGSE) NOE studies.
Bugni
Tim S
TS
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California 92093-0204, USA.
Woolery
Matthew
M
Kauffman
Christopher A
CA
Jensen
Paul R
PR
Fenical
William
W
D008386:Marine Biology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011763:Pyrrolizidine Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D013302:Streptomyces / Q000737:chemistry*
C516758:5-chlorobohemamine C; D011763:Pyrrolizidine Alkaloids; C516756:bohemamine B; C516757:bohemamine C; C025548:bohemamine