[Topic use of aqueous extract of Orbignya phalerata (babassu) in rats: analysis of its healing effect].
BACKGROUND
The mesocarp of Babassu (Orbignya phalerata) has been used in experimental studies trying to check its pro-inflammatory effect.


OBJECTIVE
To analyse comparatively the histological changes made by the water extract of Babassu in skin surgical wounds.


METHODS
Sixty Wistar adult male rats were used. The experimental procedure was a circle skin incision of 2 cm in diameter made with a metal punch. After this procedure done in all animals, they were randomized in two groups of 30. In the control group, the phytotherapeutic agent wasn't used but saline solution. In the experimental group, the water extract of Orbignya phalerata was used in the cut sites. All animals were followed and killed after seven, 14 and 21 days. Comparative histological analysis was made among the groups.


RESULTS
In the microscopic view, a significant reepitelization effect on the healing process of the experimental group in relation to the control group in the 7th and 14th days, was recognized.


CONCLUSIONS
The use of the mesocarp of Orbignya phalerata in skin surgical wounds contributed positively in the healing process in rats.
Amorim
Elias
E
Hospital, Universidade Federal do Maranhao.
Matias
Jorge Eduardo F
JE
Coelho
Júlio Cézar U
JC
Campos
Antonio Carlos L
AC
Stahlke
Henrique Jorge
HJ
Timi
Jorge Rufino Ribas
JR
Rocha
Luiz Carlos de Almeida
LC
Moreira
Ana Tereza Ramos
AT
Rispoli
Daniel Zeni
DZ
Ferreira
Lydia Masako
LM
D000287:Administration, Topical; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D003059:Cocos / Q000737:chemistry*; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use; D011184:Postoperative Period; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D012867:Skin / Q000293:injuries* / Q000648:ultrastructure; D013997:Time Factors; D014945:Wound Healing / Q000187:drug effects* / Q000502:physiology
D000893:Anti-Inflammatory Agents; D010936:Plant Extracts