[Polycystic ovary syndrome: an example of obesity-related cardiovascular complication affecting young women].
Polycystic ovary syndrome (PCOS) is a good example of obesity-related cardiovascular complication affecting young women. PCOS is not only considered a reproductive problem but rather represents a complex endocrine, multifaceted syndrome with important health implications. Several evidences suggest an increased cardiovascular risk of cardiovascular disease associated with this syndrome, characterized by an impairment of heart structure and function, endothelial dysfunction and lipid abnormalities. All these features, probably linked to insulin-resistance, are often present in obese PCOS patients. Cardiovascular abnormalities represent important long-term sequelae of PCOS that need further investigations.
Orio
Francesco
F
Department of Molecular & Clinical Endocrinology and Oncology, University Federico II of Naples, Via S. Pansini 5, 80131 Naples, Italy. francescoorio@virgilio.it
Cascella
Teresa
T
Giallauria
Francesco
F
Palomba
Stefano
S
De Lorenzo
Anna
A
Lucci
Rosa
R
Ambrosino
Elena
E
Lombardi
Gaetano
G
Colao
Annamaria
A
Vigorito
Carlo
C
D015415:Biomarkers / Q000097:blood; D002318:Cardiovascular Diseases / Q000097:blood / Q000209:etiology* / Q000503:physiopathology; D019332:Endothelin-1 / Q000097:blood; D005260:Female; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000209:etiology; D007333:Insulin Resistance; D009765:Obesity / Q000097:blood / Q000150:complications* / Q000503:physiopathology; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000150:complications* / Q000503:physiopathology; D018570:Risk Assessment; D012307:Risk Factors
D015415:Biomarkers; D019332:Endothelin-1; D017395:Plasminogen Activator Inhibitor 1