title: Valvular heart disease in a patient taking benfluorex.
abstract: The authors describe a case of valvular heart disease in a 48-year-old woman receiving benfluorex (150 mg t.i.d. for 8 years) and leading to surgical mitral valve replacement. Examination showed severe dyspnea with severe mitral regurgitation associated with tricuspid regurgitation. No other common disease known to affect mitral valves nor intake of other drugs (ergot derivatives or appetite suppressant drugs) was found. The paper discusses the imputability of benfluorex, a drug used as an adjuvant in hypercholesterolemia, structurally related to amphetamines.
authors.affiliation: Service de Pharmacologie Clinique, Centre Midi-Pyrénées de PharmacoVigilance, de Pharmacoépidémiologie et d'Informations sur le Médicament, CHU, Faculté de Médecine, Université Paul Sabatier, 37 allées Jules Guesde, 31000 Toulouse, France.
authors.forename: P
authors.initials: P
authors.lastname: Noize
authors.forename: M
authors.initials: M
authors.lastname: Sauer
authors.forename: P
authors.initials: P
authors.lastname: Bruneval
authors.forename: M
authors.initials: M
authors.lastname: Moreau
authors.forename: A
authors.initials: A
authors.lastname: Pathak
authors.forename: H
authors.initials: H
authors.lastname: Bagheri
authors.forename: J L
authors.initials: JL
authors.lastname: Montastruc
mesh_terms: D005260:Female; D005277:Fenfluramine / Q000009:adverse effects / Q000031:analogs & derivatives*; D018149:Glucose Intolerance / Q000188:drug therapy; D006801:Humans; D008875:Middle Aged; D008944:Mitral Valve Insufficiency / Q000209:etiology*; D014262:Tricuspid Valve Insufficiency / Q000209:etiology
chemical_list: D005277:Fenfluramine; C001584:benfluorex