Clinical significance of a blood eosinophilia in adult T-cell leukemia/lymphoma: a blood eosinophilia is a significant unfavorable prognostic factor.
We investigated the clinical significance of a blood eosinophilia in a cohort of 158 consecutive patients with adult T-cell leukemia/lymphoma (ATLL), and multivariate analysis revealed that a blood eosinophilia was an independent and a significant unfavorable prognostic factor. Interestingly, a blood eosinophilia was independent of serum LDH level, which might reflect the tumor burden. The present study shows that measurement of the blood eosinophil count is useful for predicting the prognosis and for determining a suitable treatment strategy for ATLL patients.
Utsunomiya
Atae
A
Department of Hematology, Imamura Bun-in Hospital, 11-23 Kamoikeshin-machi, Kagoshima-shi, Kagoshima 890-0064, Japan.
Ishida
Takashi
T
Inagaki
Atsushi
A
Ishii
Toshihiko
T
Yano
Hiroki
H
Komatsu
Hirokazu
H
Iida
Shinsuke
S
Yonekura
Kentaro
K
Takeuchi
Shogo
S
Takatsuka
Yoshifusa
Y
Ueda
Ryuzo
R
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D015331:Cohort Studies; D004802:Eosinophilia / Q000175:diagnosis*; D004804:Eosinophils / Q000473:pathology; D005260:Female; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000097:blood; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000175:diagnosis*; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate; D016896:Treatment Outcome
D015415:Biomarkers; D007770:L-Lactate Dehydrogenase