title: The emerging role of cannabinoid neuromodulators in symptom management.
abstract: BACKGROUND
  The cannabinoids nabilone (Cesamet) and dronabinol (Marinol) are indicated for the management of chemotherapy-induced nausea and vomiting (CINV) in cancer patients who have failed to respond adequately to conventional antiemetic therapy.
  
  
  CONCLUSIONS
  The endocannabinoid (CB) system interacts with numerous other systems and pharmaceutical cannabinoids target ubiquitous CB1 and CB2 receptors in the central nervous system and periphery, relieving nausea and vomiting and pain.
  
  
  CONCLUSIONS
  The benefits of this novel class of medications in cancer may extend beyond CINV, as indicated by data from preclinical studies and animal models.
authors.affiliation: The Harry R. Horvitz Center for Palliative Medicine, Cleveland Clinic, Cleveland, OH 44195, USA. davism6@ccf.org
authors.forename: Mellar
authors.initials: M
authors.lastname: Davis
authors.forename: Vincent
authors.initials: V
authors.lastname: Maida
authors.forename: Paul
authors.initials: P
authors.lastname: Daeninck
authors.forename: Joseph
authors.initials: J
authors.lastname: Pergolizzi
mesh_terms: D000284:Administration, Oral; D018712:Analgesics, Non-Narcotic / Q000493:pharmacokinetics / Q000627:therapeutic use*; D000932:Antiemetics / Q000493:pharmacokinetics / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000009:adverse effects; D001943:Breast Neoplasms / Q000150:complications; D013759:Dronabinol / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008875:Middle Aged; D010146:Pain / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D043882:Receptors, Cannabinoid / Q000187:drug effects*; D013125:Spinal Neoplasms / Q000150:complications; D014839:Vomiting / Q000188:drug therapy* / Q000209:etiology
chemical_list: D018712:Analgesics, Non-Narcotic; D000932:Antiemetics; D000970:Antineoplastic Agents; D043882:Receptors, Cannabinoid; C011941:nabilone; D013759:Dronabinol