[On the mechanisms of thyrocyte proliferation and death in autoimmune thyroid diseases].
Lymphocytes isolated from diffuse toxic goiter (Graves' disease, GD) stimulate the proliferation of "normal" thyrocytes (isolated from euthyroid goiter) in primary culture, and give them the properties of GD-thyrocytes (loss of sensitivity to the growth-promoting factors of FCS and lesser capacity of binding antibodies from GD patients' serum). The complement-free sera of GD patients (but not the sera of patients with Hashimoto's thyroiditis, HT) induce the death of "normal" thyrocytes more rarely than full-complement sera do. Both types of serum cytotoxicity are manifested on GD-thyrocytes much more rarely than on "normal" cells. The Fas-receptor on GD-thyrocytes in situ is expressed less than on "normal" and especially on HT-cells. The level of soluble Fas-ligand in the serum of some complement-free patients was found to be increased. These sera induce apoptosis in "normal" thyrocytes, but not in GD-cells nor in human skin fibroblasts. In the authors' opinion, the proliferation of GD-thyrocytes in situ is stimulated by intrathyroid lymphocytes, which directly stimulate this process and induce the loss of receptors which mediate the cytotoxic effects of serum factors.
Kandror
V I
VI
Kraĭnova
S I
SI
Kriukova
I V
IV
Mkrtumova
N A
NA
D017209:Apoptosis; D002455:Cell Division; D002478:Cells, Cultured; D053222:Fas Ligand Protein; D006111:Graves Disease / Q000097:blood / Q000276:immunology / Q000473:pathology*; D050031:Hashimoto Disease / Q000097:blood / Q000276:immunology / Q000473:pathology*; D006801:Humans; D008214:Lymphocytes / Q000276:immunology; D013961:Thyroid Gland / Q000166:cytology* / Q000276:immunology; D019014:fas Receptor
D053222:Fas Ligand Protein; D019014:fas Receptor