Influence of Crocetin on experimental atherosclerosis in hyperlipidamic-diet quails.
Antioxidants have been expected to have potential as antiatherogenic agents. Crocetin is a natural carotenoid antioxidant isolated from Gardenia jasminoids Ellis. Therefore, in the present study, we investigated the inhibitory effect of Crocetin on experimental atherosclerosis in quails. The atherosclerosis model was established by feeding hyperlipidamic diet to quail and Crocetin (25, 50, 100 mg/kg/day) was administered by oral gavage. At the 9th week, serum lipids, malondialdehyde and nitric oxide were measured, and Hematoxylin-Eosin (H&E) stains was used to investigate the histopathological changes of aorta. Results showed that Crocetin could reduce the levels of serum total cholesterol, triglyceride, low density lipoprotein cholesterol and inhibit the formation of aortic plaque. Crocetin could also reduce malondialdehyde and inhibit the descending of nitric oxide in serum. The results suggested that Crocetin could inhibit the formation of atherosclerosis in quails, which might be related to the hypolipidemic effects along with the antioxidative properties of Crocetin.
He
Shu-Ying
SY
School of Life Science and Technology, China Pharmaceutical University, Nanjing, 210009, China. heshuying66@sohn.com
Qian
Zhi-Yu
ZY
Wen
Na
N
Tang
Fu-Tian
FT
Xu
Guang-Lin
GL
Zhou
Cheng-Hua
CH
D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000494:pharmacology; D001011:Aorta / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D050197:Atherosclerosis / Q000097:blood / Q000139:chemically induced / Q000517:prevention & control*; D002338:Carotenoids / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D002784:Cholesterol / Q000097:blood; D002791:Cholesterol, Dietary / Q000008:administration & dosage / Q000633:toxicity; D008078:Cholesterol, LDL / Q000097:blood; D015243:Cholesterol, VLDL / Q000097:blood; D004036:Diet, Atherogenic; D004041:Dietary Fats / Q000008:administration & dosage / Q000633:toxicity; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D008055:Lipids / Q000032:analysis / Q000097:blood; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D015394:Molecular Structure; D009569:Nitric Oxide / Q000097:blood; D011784:Quail; D014280:Triglycerides / Q000097:blood; D014801:Vitamin A / Q000031:analogs & derivatives
D000975:Antioxidants; D002791:Cholesterol, Dietary; D008078:Cholesterol, LDL; D015243:Cholesterol, VLDL; D004041:Dietary Fats; D008055:Lipids; D014280:Triglycerides; C487773:trans-sodium crocetinate; D014801:Vitamin A; D009569:Nitric Oxide; D002338:Carotenoids; D008315:Malondialdehyde; D002784:Cholesterol