title: Detection of four lymphotropic herpesviruses in Hungarian patients with multiple myeloma and lymphoma.
abstract: It has been suggested that human herpesvirus 8 (HHV-8), also known as KSHV (Kaposi's sarcoma-associated human herpesvirus), might possess a promoting effect in the development and progression of monoclonal gammopathies. In this study, the presence of Epstein-Barr virus (EBV), human cytomegalovirus (CMV), human herpesvirus 6 (HHV-6) and human herpesvirus 8 (HHV-8) were tested in patients with multiple myeloma (MM) using both serologic and nucleic acid amplification techniques. The transient reactivation or continuous presence of EBV, CMV, HHV-6 and HHV-8 could be detected in, respectively, 36, eight, 13 and 29 of 69 MM patients; nine, one, four and six of 16 monoclonal gammopathy of unknown significance patients; and seven, four, zero and five of 10 Waldenström's macroglobulinemia patients. The total number of MM patients was 95. HHV-8 PCR-positivity was significantly more frequent in the MM group than in the control group of patients with non-Hodgkin's lymphoma (NHL). However, serologic testing did not reveal significant differences between the two patient groups. The number of MM patients with concomitant herpesvirus infections as detected by PCR was as follows: 15 double, seven triple and two quadruple virus nucleic acid positive. In 13/95 MM patients, the simultaneous presence of acute EBV infection and HHV-8 PCR-positivity was detected compared with none of the control group (P=0.009). These results indicate that in addition to HHV-8, the transitional reactivation of EBV may also play a role in the pathogenesis of MM.
authors.affiliation: Division of Virology, National Center for Epidemiology, Budapest, Hungary. csirem@oek.antsz.hu
authors.forename: Márta
authors.initials: M
authors.lastname: Csire
authors.forename: Gábor
authors.initials: G
authors.lastname: Mikala
authors.forename: Mónika
authors.initials: M
authors.lastname: Peto
authors.forename: Judit
authors.initials: J
authors.lastname: Jánosi
authors.forename: Attila
authors.initials: A
authors.lastname: Juhász
authors.forename: Attila
authors.initials: A
authors.lastname: Tordai
authors.forename: János
authors.initials: J
authors.lastname: Jákó
authors.forename: Gyula
authors.initials: G
authors.lastname: Domján
authors.forename: János
authors.initials: J
authors.lastname: Dolgos
authors.forename: György
authors.initials: G
authors.lastname: Berencsi
authors.forename: István
authors.initials: I
authors.lastname: Vályi-Nagy
mesh_terms: D000818:Animals; D002144:Callithrix; D006564:Herpesviridae / Q000235:genetics* / Q000276:immunology; D006566:Herpesviridae Infections / Q000150:complications / Q000276:immunology / Q000821:virology; D006801:Humans; D006814:Hungary; D007074:Immunoglobulin G / Q000097:blood; D008223:Lymphoma / Q000276:immunology / Q000821:virology*; D009101:Multiple Myeloma / Q000276:immunology / Q000821:virology*; D016133:Polymerase Chain Reaction / Q000379:methods; D012699:Serology / Q000379:methods
chemical_list: D007074:Immunoglobulin G