Oncostatin m maintains the hematopoietic microenvironment and retains hematopoietic progenitors in the bone marrow.
Bone marrow (BM) functions as the primary hematopoietic tissue throughout adult life by providing a microenvironment for the proliferation, differentiation, and retention of hematopoietic stem cells and progenitors. We describe novel roles for oncostatin M (OSM) in the BM hematopoietic microenvironment. Hematopoietic progenitor activity in OSM-deficient mice was reduced in BM but elevated in the spleen and peripheral blood. The level of circulating granulocyte colony-stimulating factor (G-CSF) was increased, whereas that of stromal cell-derived factor 1 (SDF-1) was decreased in OSM-deficient mice. Moreover, the ability of OSM-deficient BM stromal cells to support hematopoiesis in vitro was significantly reduced. These results indicate that OSM plays a unique role in hematopoiesis by maintaining the proper microenvironment for BM hematopoiesis; it also retains hematopoietic progenitors in BM by regulating G-CSF and SDF-1 levels.
Minehata
Ken-ichi
K
Institute of Molecular and Cellular Biosciences, University of Tokyo, Tokyo, Japan.
Takeuchi
Masaki
M
Hirabayashi
Yoko
Y
Inoue
Tohru
T
Donovan
Peter J
PJ
Tanaka
Minoru
M
Miyajima
Atsushi
A
D000818:Animals; D001853:Bone Marrow; D002478:Cells, Cultured; D054377:Chemokine CXCL12; D019743:Chemokines, CXC / Q000097:blood; D016179:Granulocyte Colony-Stimulating Factor / Q000097:blood; D006410:Hematopoiesis; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D051379:Mice; D018345:Mice, Knockout; D053683:Oncostatin M / Q000172:deficiency / Q000502:physiology*; D017154:Stromal Cells
D054377:Chemokine CXCL12; D019743:Chemokines, CXC; C515256:Cxcl12 protein, mouse; D053683:Oncostatin M; D016179:Granulocyte Colony-Stimulating Factor