title: Case report vancomycin -resistant Enterococcus faecium VanA phenotype: first documented isolation in India.
abstract: In recent years, vancomycin-resistant enterococci, especially Enterococcus faecium has emerged as an important nososcomial pathogen and represents a serious threat to patients with impaired host defences. We report infection with vancomycin-resistant Enterococcus faecium in a 3-year-old child with patent ductus arteriosus. The organism, isolated from a central venous catheter tip, exhibited a high-level resistance to vancomycin (minimum inhibitory concentration > or = 256 microg/ ml) and was also resistant to teicoplanin. The child probably died due to sepsis from this highly resistant organism. To the best of our knowledge, this is the first reported isolation of VanA phenotype Enterococcus faecium in India.
authors.affiliation: Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Srujana
authors.initials: S
authors.lastname: Mohanty
authors.forename: Benu
authors.initials: B
authors.lastname: Dhawan
authors.forename: R S
authors.initials: RS
authors.lastname: Gadepalli
authors.forename: Rakesh
authors.initials: R
authors.lastname: Lodha
authors.forename: Arti
authors.initials: A
authors.lastname: Kapil
mesh_terms: D001426:Bacterial Proteins; D019729:Carbon-Oxygen Ligases; D002404:Catheterization / Q000009:adverse effects*; D002675:Child, Preschool; D003428:Cross Infection; D004374:Ductus Arteriosus, Patent / Q000150:complications; D016984:Enterococcus faecium / Q000187:drug effects / Q000235:genetics; D004866:Equipment Contamination; D017809:Fatal Outcome; D005260:Female; D016908:Gram-Positive Bacterial Infections / Q000175:diagnosis* / Q000382:microbiology / Q000401:mortality; D006801:Humans; D007194:India; D008826:Microbial Sensitivity Tests; D010641:Phenotype; D018805:Sepsis / Q000175:diagnosis / Q000382:microbiology / Q000401:mortality; D020713:Vancomycin Resistance / Q000235:genetics*
chemical_list: D001426:Bacterial Proteins; C071437:VanA ligase, Bacteria; D019729:Carbon-Oxygen Ligases