title: TSH receptor antibodies in subjects with type 1 diabetes mellitus.
abstract: The research was undertaken to study the prevalence of TSH receptor antibody positivity in patients with type 1 diabetes. A total of 74 subjects with type 1 diabetes were enrolled in this cross-sectional study. Thyroid function test and assessment of thyroid autoimmunity with anti-TPO and TSH receptor antibody were done in all patients. A total of 33 males and 41 females with type 1 diabetes were studied. The prevalence of TSH receptor antibody positivity alone was 18%. The prevalence of thyroid autoimmunity with anti-TPO as a marker was 28%; the prevalence increased to 43% when TSH receptor antibody was also measured. Majority of the subjects with antithyroid antibody positivity were also positive for GAD65 antibodies. As a significant proportion of type 1 diabetic subjects have positivity to TSH receptor antibody, we suggest that larger studies should be conducted to study the benefits of TSH receptor antibody-based screening for thyroid dysfunction in type 1 diabetic subjects. As the TSH receptor antibodies could be of the stimulating or of the blocking type, subjects with antibody positivity could be at risk of developing hyperthyroidism or hypothyroidism.
authors.affiliation: Department of Endocrinology, Amrita Institute of Medical Sciences, Cochin, Kerala 682-026, India.
authors.forename: Ambika G
authors.initials: AG
authors.lastname: Unnikrishnan
authors.forename: Velayutham
authors.initials: V
authors.lastname: Kumaravel
authors.forename: Vasantha
authors.initials: V
authors.lastname: Nair
authors.forename: Ananth
authors.initials: A
authors.lastname: Rao
authors.forename: Rohini V
authors.initials: RV
authors.lastname: Jayakumar
authors.forename: Harish
authors.initials: H
authors.lastname: Kumar
authors.forename: Carani B
authors.initials: CB
authors.lastname: Sanjeevi
mesh_terms: D000293:Adolescent; D000328:Adult; D000906:Antibodies / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D002648:Child; D003430:Cross-Sectional Studies; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology / Q000276:immunology / Q000503:physiopathology; D005260:Female; D006111:Graves Disease / Q000097:blood / Q000453:epidemiology / Q000276:immunology; D006801:Humans; D007194:India / Q000453:epidemiology; D008297:Male; D010865:Pilot Projects; D015995:Prevalence; D011446:Prospective Studies; D011989:Receptors, Thyrotropin / Q000276:immunology*; D013960:Thyroid Function Tests; D013967:Thyroiditis, Autoimmune / Q000097:blood / Q000453:epidemiology / Q000276:immunology
chemical_list: D000906:Antibodies; D015415:Biomarkers; D011989:Receptors, Thyrotropin