[A pregnant woman with nephrotic syndrome and focal segmental lesions].
A 32-year-old woman was admitted at 36 weeks' gestation because of increasing proteinuria and generalized edema. At the time of admission, serum creatinine was 1.3 mg/dl, and urinalysis demonstrated 4+ protein and 2+ occult blood. During her pregnancy, her blood pressure had been in the normal range. A normal healthy female neonate was delivered by caesarean section at 38 weeks' gestation. After delivery, the woman's 24-hour urine protein excretion was 11 g/day and serum albumin was 1.4 g/dl , hence nephrotic syndrome was diagnosed. Eleven days after delivery, a renal biopsy showed focal segmental lesions with glomerular epithelial cell injury. She was given 50 mg/day prednisolone and after a month, her 24-hour urinary protein excretion decreased to 2 g/day. One year later, she achieved complete remission. Although she had a relapse of nephrotic syndrome after twenty-one months, steroid therapy again achieved a good response.
Wada
Toshikazu
T
Department of Nephrology, Tokyo Medical University, Tokyo, Japan.
Nagaoka
Yume
Y
Matsumoto
Hiroshi
H
Okada
Tomonari
T
Han
Myeonggi
M
Yoshino
Maki
M
Iwasawa
Hideaki
H
Tomaru
Ryou
R
Uchinaga
Asako
A
Ake
Tokiyo
T
Nakao
Toshiyuki
T
Nagao
Toshitaka
T
D000328:Adult; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage; D005260:Female; D005923:Glomerulosclerosis, Focal Segmental / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D006801:Humans; D009404:Nephrotic Syndrome / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D011239:Prednisolone / Q000008:administration & dosage; D011247:Pregnancy; D011248:Pregnancy Complications
D000893:Anti-Inflammatory Agents; D011239:Prednisolone