Platelet activation in different clinical forms of the coronary artery disease (role of P-selectin and others platelet markers in stable and unstable angina).
OBJECTIVE
Markers of platelet activation are elevated in coronary artery disease. We sought to identify the presence and the potential associations of different markers of platelet activation.


METHODS
We studied patients with unstable angina (n=28), patients with stable angina (n=36) and patients without coronary artery disease (n=30); sex and age matched. Blood levels of the adhesion molecule P-selectin, Thromboxane B2 and Serotonin were measured by enzyme immunoassays.


RESULTS
When we compared the groups the results were: sP-selectin, thromboxane B2 and serotonin levels were significantly higher in patients with unstable angina than in patients with stable angina.


CONCLUSIONS
These markers of platelet activation were able to identify unstable forms of coronary artery disease.
Venturinelli
Margareth L
ML
Instituto do Coração, Hospital das Clínicas, FM, USP, São Paulo, SP.
Hovnan
André
A
Soeiro
Alexandre de Matos
Ade M
Nicolau
José Carlos
JC
Ramires
José A F
JA
D'Amico
Elbio A
EA
Serrano
Carlos Vicente
CV
D000787:Angina Pectoris / Q000097:blood / Q000503:physiopathology*; D015415:Biomarkers / Q000097:blood; D003324:Coronary Artery Disease / Q000097:blood / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019007:P-Selectin / Q000097:blood; D015539:Platelet Activation / Q000502:physiology*; D012701:Serotonin / Q000097:blood; D013929:Thromboxane B2 / Q000097:blood
D015415:Biomarkers; D019007:P-Selectin; D012701:Serotonin; D013929:Thromboxane B2