Rearrangement of 3,3-disubstituted indolenines and synthesis of 2,3-substituted indoles.
Synthesis of 2,3-substituted indoles from phenylhydrazine and alpha-branched aldehydes via rearrangement of 3,3-disubstituted indolenine intermediates is reported. [reaction: see text]
Liu
Kevin G
KG
Chemical & Screening Sciences, Wyeth Research, CN 8000, Princeton, NJ 08543, USA. liuk1@wyeth.com
Robichaud
Albert J
AJ
Lo
Jennifer R
JR
Mattes
James F
JF
Cai
Yanxuan
Y
D000447:Aldehydes / Q000737:chemistry; D002384:Catalysis; D007211:Indoles / Q000138:chemical synthesis*; D009682:Magnetic Resonance Spectroscopy; D010659:Phenylhydrazines / Q000737:chemistry; D012997:Solvents
D000447:Aldehydes; D007211:Indoles; D010659:Phenylhydrazines; D012997:Solvents; C030299:phenylhydrazine