title: Effect of human body weight changes on circulating levels of peptide YY and peptide YY3-36.
abstract: BACKGROUND
  Recent findings suggest that low plasma peptide YY (PYY) levels may contribute to diet-induced human obesity and justify PYY replacement therapy. Although the pharmacological value of PYY is controversial, further study of the secretion of the precursor PYY(1-36) and the pharmacologically active PYY(3-36) is indicated to determine the potential role in energy balance regulation.
  
  
  OBJECTIVE
  Our objective was to determine the effects of acute and chronic changes in human body weight on circulating levels of the putative satiety hormone peptide YY.
  
  
  METHODS
  Total plasma PYY levels (PYY(1-36) + PYY(3-36)) were measured in 66 lean, 18 anorectic, 63 obese, and 16 morbidly obese humans. In addition, total PYY was measured in 17 of the obese patients after weight loss and in the 18 anorectic patients after weight gain. Fasting PYY(3-36) levels were measured in 17 lean and 15 obese individuals.
  
  
  RESULTS
  Fasting total plasma PYY levels were highest in patients with anorexia nervosa (80.9 +/- 12.9 pg/ml, P < 0.05) compared with lean (52.4 +/- 4.6 pg/ml), obese (43.9 +/- 3.8 pg/ml), or morbidly obese (45.6 +/- 11.2 pg/ml) subjects. In obese patients, weight loss of 5.4% was associated with a 30% decrease in fasting total PYY plasma levels. In anorectic patients, weight gain had no effect on fasting PYY. PYY(3-36) levels did not differ between lean (96.2 +/- 8.6 pg/ml) and obese (91.5 +/- 6.9 pg/ml) subjects.
  
  
  CONCLUSIONS
  Our findings do not support a role for abnormal circulating PYY in human obesity. We conclude that circulating PYY levels in humans are significantly elevated in anorexia nervosa and, given the controversially discussed anorectic effect of PYY, could theoretically contribute to that syndrome.
authors.affiliation: Department of Psychiatry, University of Cincinnati, Office E-217, Genome Research Institute, 2170 East Galbraith Road, Cincinnati, Ohio 45237, USA.
authors.forename: P T
authors.initials: PT
authors.lastname: Pfluger
authors.forename: J
authors.initials: J
authors.lastname: Kampe
authors.forename: T R
authors.initials: TR
authors.lastname: Castaneda
authors.forename: T
authors.initials: T
authors.lastname: Vahl
authors.forename: D A
authors.initials: DA
authors.lastname: D'Alessio
authors.forename: T
authors.initials: T
authors.lastname: Kruthaupt
authors.forename: S C
authors.initials: SC
authors.lastname: Benoit
authors.forename: U
authors.initials: U
authors.lastname: Cuntz
authors.forename: H J
authors.initials: HJ
authors.lastname: Rochlitz
authors.forename: M
authors.initials: M
authors.lastname: Moehlig
authors.forename: A F H
authors.initials: AF
authors.lastname: Pfeiffer
authors.forename: C
authors.initials: C
authors.lastname: Koebnick
authors.forename: M O
authors.initials: MO
authors.lastname: Weickert
authors.forename: B
authors.initials: B
authors.lastname: Otto
authors.forename: J
authors.initials: J
authors.lastname: Spranger
authors.forename: M H
authors.initials: MH
authors.lastname: Tschöp
mesh_terms: D000328:Adult; D000855:Anorexia / Q000378:metabolism / Q000503:physiopathology*; D001835:Body Weight / Q000502:physiology*; D002149:Energy Intake / Q000502:physiology; D005215:Fasting / Q000502:physiology; D005260:Female; D006801:Humans; D020738:Leptin / Q000097:blood; D009767:Obesity, Morbid / Q000378:metabolism / Q000503:physiopathology*; D010446:Peptide Fragments; D019894:Peptide YY / Q000097:blood*; D011956:Receptors, Cell Surface / Q000097:blood; D054411:Receptors, Leptin; D012528:Satiety Response / Q000502:physiology*; D015430:Weight Gain / Q000502:physiology; D015431:Weight Loss / Q000502:physiology
chemical_list: D020738:Leptin; D010446:Peptide Fragments; D011956:Receptors, Cell Surface; D054411:Receptors, Leptin; D019894:Peptide YY; C061785:peptide YY (3-36)