title: 'Click peptide': a novel 'O-acyl isopeptide method' for peptide synthesis and chemical biology-oriented synthesis of amyloid beta peptide analogues.
abstract: After over a decade of studies on aspartic protease inhibitors and water-soluble prodrugs, we have been developing a novel method, since 2003, called 'O-acyl isopeptide method', for the synthesis of peptides containing difficult sequences. With our recent discoveries of 'O-acyl isodipeptide unit' and the 'racemization-free segment condensation method', this method has further evolved as a general synthetic method for peptides. Moreover, 'Click Peptide', which could be a powerful tool for identifying the pathological functions of amyloid beta peptides in Alzheimer's disease, represents a valuable use of the isopeptide method in Chemical Biology-oriented research.
authors.affiliation: Department of Medicinal Chemistry, Center for Frontier Research in Medicinal Science, 21st Century COE Program, Kyoto Pharmaceutical University, Yamashina-ku, Kyoto 607-8412.
authors.forename: Youhei
authors.initials: Y
authors.lastname: Sohma
authors.forename: Atsuhiko
authors.initials: A
authors.lastname: Taniguchi
authors.forename: Taku
authors.initials: T
authors.lastname: Yoshiya
authors.forename: Yousuke
authors.initials: Y
authors.lastname: Chiyomori
authors.forename: Fukue
authors.initials: F
authors.lastname: Fukao
authors.forename: Setsuko
authors.initials: S
authors.lastname: Nakamura
authors.forename: Mariusz
authors.initials: M
authors.lastname: Skwarczynski
authors.forename: Takuma
authors.initials: T
authors.lastname: Okada
authors.forename: Keisuke
authors.initials: K
authors.lastname: Ikeda
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Hayashi
authors.forename: Tooru
authors.initials: T
authors.lastname: Kimura
authors.forename: Shun
authors.initials: S
authors.lastname: Hirota
authors.forename: Katsumi
authors.initials: K
authors.lastname: Matsuzaki
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Kiso
mesh_terms: D000215:Acylation; D000595:Amino Acid Sequence; D016229:Amyloid beta-Peptides / Q000138:chemical synthesis* / Q000737:chemistry; D004355:Drug Stability; D008956:Models, Chemical; D008969:Molecular Sequence Data; D015394:Molecular Structure; D010446:Peptide Fragments / Q000138:chemical synthesis* / Q000737:chemistry; D011355:Prodrugs / Q000138:chemical synthesis / Q000737:chemistry
chemical_list: D016229:Amyloid beta-Peptides; D010446:Peptide Fragments; D011355:Prodrugs