title: Blastic natural killer cell leukaemia in a dog--a case report.
abstract: A case of canine non-T, non-B lymphoid leukaemia was determined to be of natural killer (NK) cell lineage by detecting specific expression of canine CD56 mRNA by reverse transcriptase polymerase chain reaction analysis. Although NK cells are usually considered to be morphologically large granular lymphocytes, the malignant NK cells in this case were agranular and blast-like, resembling human blastic NK cell leukaemia. The prognosis of human NK cell leukaemia is usually poor. In this case, the dog died 10 days after initial presentation, despite chemotherapy.
authors.affiliation: Department of Veterinary Clinical Pathology, Nippon Veterinary and Life Science University, 1-7-1 Kyonan-cho, Musashino-shi, Tokyo 180-8602, Japan. bonkobara@nvlu.ac.jp
authors.forename: Makoto
authors.initials: M
authors.lastname: Bonkobara
authors.forename: Taro
authors.initials: T
authors.lastname: Saito
authors.forename: Masahiro
authors.initials: M
authors.lastname: Yamashita
authors.forename: Kyoichi
authors.initials: K
authors.lastname: Tamura
authors.forename: Hiroko
authors.initials: H
authors.lastname: Yagihara
authors.forename: Mayu
authors.initials: M
authors.lastname: Isotani
authors.forename: Takashi
authors.initials: T
authors.lastname: Sato
authors.forename: Tsukimi
authors.initials: T
authors.lastname: Washizu
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D019002:CD56 Antigen / Q000235:genetics / Q000378:metabolism; D004283:Dog Diseases / Q000175:diagnosis* / Q000188:drug therapy; D004285:Dogs; D004317:Doxorubicin / Q000627:therapeutic use; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D054066:Leukemia, Large Granular Lymphocytic / Q000175:diagnosis / Q000188:drug therapy / Q000662:veterinary*; D012333:RNA, Messenger / Q000235:genetics; D014750:Vincristine / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D019002:CD56 Antigen; D012333:RNA, Messenger; D014750:Vincristine; D004317:Doxorubicin