title: Telomere dysfunction: a new player in radiation sensitivity.
abstract: Human individuals often exhibit important differences in their sensitivity to ionising radiation. Extensive literature links radiation sensitivity with impaired DNA repair which is due to a lack of correct functioning in many proteins involved in DNA-repair pathways and/or in DNA-damage checkpoint responses. Given that ionising radiation is an important and widespread diagnostic and therapeutic tool, it is important to investigate further those factors and mechanisms that underlie individual radiosensitivity. Recently, evidence is accumulating that telomere function may well be involved in cellular and organism responses to ionising radiation, broadening still further the currently complex and challenging scenario.
authors.affiliation: Department of Cell Biology, Physiology and Immunology, Universitat Autònoma de Barcelona, Spain. anna.genesca@uab.es
authors.forename: Anna
authors.initials: A
authors.lastname: Genescà
authors.forename: Marta
authors.initials: M
authors.lastname: Martín
authors.forename: Laura
authors.initials: L
authors.lastname: Latre
authors.forename: David
authors.initials: D
authors.lastname: Soler
authors.forename: Judit
authors.initials: J
authors.lastname: Pampalona
authors.forename: Laura
authors.initials: L
authors.lastname: Tusell
mesh_terms: D006801:Humans; D009690:Nucleic Acid Conformation; D011835:Radiation Protection; D011836:Radiation Tolerance; D016615:Telomere / Q000737:chemistry / Q000378:metabolism* / Q000528:radiation effects*; D034501:Telomere-Binding Proteins / Q000378:metabolism
chemical_list: D034501:Telomere-Binding Proteins