Chemical composition and in vitro antifungal and antioxidant activity of the essential oil and methanolic extract of Teucrium sauvagei Le Houerou.
The chemical composition and the in vitro antifungal and antioxidant activity of the essential oil and the methanolic leaf extracts of Teucrium sauvagei Le Houerou, an endemic medicinal plant growing in Tunisia, have been studied. More than 35 constituents having an abundance >or=0.2% were identified in the oil. beta-Eudesmol, T-cadinol, alpha-thujene, gamma-cadinene, and sabinene were the prevalent constituents. Results of the antifungal activity tests indicated that the methanolic extract inhibited the in vitro growth of seven dermatophytes, whereas the essential oil showed average inhibition against only three dermatophytes. In vitro antioxidant properties of the essential oil and the methanolic extract were determined by DPPH (2,2-diphenyl-1-picrylhydrazyl) and ABTS (2,2'-azinobis(3-ethylbenzothiazoline-6-sulphonic acid)) assays and compared to those of the synthetic antioxidant Trolox. Due to their antifungal and antioxidant properties, the essential oil and the methanolic extract of T. sauvagei may be of use as natural preservative ingredients in food and/or pharmaceutical industries.
Salah
K Bel Hadj
KB
Faculté de Pharmacie, Laboratoire des Maladies Transmissibles et Substances Biologiquement Actives, 5000 Monastir, Tunisia.
Mahjoub
M A
MA
Chaumont
J P
JP
Michel
L
L
Millet-Clerc
J
J
Chraeif
I
I
Ammar
S
S
Mighri
Z
Z
Aouni
M
M
D000935:Antifungal Agents / Q000737:chemistry* / Q000633:toxicity; D000975:Antioxidants / Q000737:chemistry* / Q000633:toxicity; D052160:Benzothiazoles; D001713:Biphenyl Compounds; D002839:Chromans / Q000633:toxicity; D005658:Fungi / Q000187:drug effects; D008401:Gas Chromatography-Mass Spectrometry; D006834:Hydrazines; D009822:Oils, Volatile / Q000737:chemistry* / Q000633:toxicity; D010851:Picrates; D010936:Plant Extracts / Q000737:chemistry* / Q000633:toxicity; D018515:Plant Leaves / Q000737:chemistry*; D013451:Sulfonic Acids; D031367:Teucrium / Q000737:chemistry* / Q000633:toxicity; D014416:Tunisia
D000935:Antifungal Agents; D000975:Antioxidants; D052160:Benzothiazoles; D001713:Biphenyl Compounds; D002839:Chromans; D006834:Hydrazines; D009822:Oils, Volatile; D010851:Picrates; D010936:Plant Extracts; D013451:Sulfonic Acids; C040618:teucrium extract; C002502:2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid; C004931:1,1-diphenyl-2-picrylhydrazyl; C010643:6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid