The management of patients with limited-stage classical Hodgkin lymphoma.
The term limited-stage Hodgkin lymphoma refers to those patients with stage I-II disease and an absence of bulky disease. Among those patients with classical Hodgkin lymphoma, approximately one-third of patients will fall into this category. As long-term disease control can now be anticipated in more than 90% of these patients, management strategies must increasingly address the need to reduce the long-term treatment-related risks. Current treatment options include use of combined modality therapy that includes an abbreviated course of chemotherapy and involved-field radiation or treatment with chemotherapy, currently consisting of ABVD, as a single modality. The choice of treatment between these two options involves specific trade-offs that must balance issues of disease control against long-term risk of late effects.
Gospodarowicz
Mary K
MK
The Princess Margaret Hospital, University Health Network and the University of Toronto, Toronto, Ontario, Canada.
Meyer
Ralph M
RM
D003131:Combined Modality Therapy; D019468:Disease Management; D006689:Hodgkin Disease / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy*; D006801:Humans; D009367:Neoplasm Staging; D018570:Risk Assessment