title: [Clinical significance of pyrimidine nucleoside phosphorylase (PyNPase) in breast cancer].
abstract: To clarify the clinical significance of pyrimidine nucleoside phosphorylase (PyNPase) activity in breast cancer, we examined the possible correlation of PyNPase activity to clinicopathological features and prognosis in twenty-one patients with primary breast cancer from April 2000 to December 2001. Flow signals of tumors were analyzed by Power Doppler sonography (PDUS), and maximal velocity (V(max)) was calculated. PyNPase activity of resected specimens was assayed by ELISA method. PyNPase activities in resected cancerous tissue were 156.9+/-63.5 unit/mg (mean+/-SD), which were significantly higher than that in normal tissue (19.0+/-18.1 unit/mg, p<0.0001). PyNPase activity was positively correlated with tumor size (r=0.496, p=0.026) and V(max) (r=0.498, p=0.021). The disease free survival rate was significantly lower in the high PyNPase activity group than in the low PyNPase activity group. In overall survival rate, there was no significant difference between the high and low PyNPase activity groups. In the multivariate analysis, PyNPase activity was an independent predictor of postoperative recurrence (p=0.032). We suggest that PyNPase activity is associated with progression and proliferation of breast cancer, and that it may be useful for prediction of the prognosis.
authors.affiliation: Dept. of Surgery, Osaka Red Cross Hospital.
authors.forename: Satoru
authors.initials: S
authors.lastname: Seo
authors.forename: Akira
authors.initials: A
authors.lastname: Miki
authors.forename: Keiko
authors.initials: K
authors.lastname: Iwaisako
authors.forename: Naoko
authors.initials: N
authors.lastname: Kamo
authors.forename: Takuya
authors.initials: T
authors.lastname: Inomoto
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Kitai
authors.forename: Minoru
authors.initials: M
authors.lastname: Ukikusa
mesh_terms: D000328:Adult; D000368:Aged; D001940:Breast / Q000098:blood supply*; D001943:Breast Neoplasms / Q000201:enzymology* / Q000401:mortality / Q000473:pathology; D018270:Carcinoma, Ductal, Breast / Q000201:enzymology* / Q000401:mortality / Q000556:secondary; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D008207:Lymphatic Metastasis; D008875:Middle Aged; D009367:Neoplasm Staging; D010430:Pentosyltransferases / Q000378:metabolism*; D011379:Prognosis; D057845:Pyrimidine Phosphorylases; D012039:Regional Blood Flow / Q000502:physiology; D015996:Survival Rate
chemical_list: D010430:Pentosyltransferases; D057845:Pyrimidine Phosphorylases