title: Antimicrobial and antioxidant activities of the methanolic extracts of three Salvia species from Tunisia.
abstract: This study examines the in vitro antimicrobial and antioxidant activities of the methanolic extracts of three Salvia species from Tunisia: Salvia aegyptiaca L., S. argentea L. and S. verbenaca Ssp. clandestina L. Pugsley. The extracts inhibited the growth of dermatophytes and of bacteria responsible for unpleasant odours to varying degrees; the pathogenic yeasts Candida albicans and Cryptococcus neoformans, the filamentous fungi Aspergillus fumigatus and selected dog otitis bacteria were all resistant to each of the extracts. The extracts were screened for their antioxidant activities using 2,2-diphenyl-1-picrylhydrazyl free radical scavenging and 2,2'-azinobis(3-ethylbenzothiazoline-6-sulphonic acid) test systems, and gave positive results in both tests. The extracts of S. aegyptiaca were the most active in both tests, followed by those of S. verbenaca, then S. argentea. These results confirm the antimicrobial and antioxidant activities of the genus Salvia and underline the potential of these plants either as natural preservatives or in pharmaceutical applications.
authors.affiliation: Faculté de Pharmacie, Laboratoire des Maladies Transmissibles et Substances Biologiquement Actives, 5000 Monastir, Tunisia.
authors.forename: Karima Bel Hadj
authors.initials: KB
authors.lastname: Salah
authors.forename: Mohamed Ali
authors.initials: MA
authors.lastname: Mahjoub
authors.forename: Samia
authors.initials: S
authors.lastname: Ammar
authors.forename: Laura
authors.initials: L
authors.lastname: Michel
authors.forename: Joelle
authors.initials: J
authors.lastname: Millet-Clerc
authors.forename: Jean Pierre
authors.initials: JP
authors.lastname: Chaumont
authors.forename: Zine
authors.initials: Z
authors.lastname: Mighri
authors.forename: Mahjoub
authors.initials: M
authors.lastname: Aouni
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry / Q000633:toxicity*; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D052160:Benzothiazoles; D001713:Biphenyl Compounds; D016956:Burkholderia cepacia / Q000187:drug effects; D005609:Free Radicals / Q000378:metabolism; D005658:Fungi / Q000187:drug effects; D000432:Methanol; D010851:Picrates; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry*; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D027544:Salvia / Q000737:chemistry*; D013045:Species Specificity; D013210:Staphylococcus / Q000187:drug effects; D013451:Sulfonic Acids; D014416:Tunisia
chemical_list: D000890:Anti-Infective Agents; D000975:Antioxidants; D052160:Benzothiazoles; D001713:Biphenyl Compounds; D005609:Free Radicals; D010851:Picrates; D010936:Plant Extracts; D013451:Sulfonic Acids; C002502:2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid; C004931:1,1-diphenyl-2-picrylhydrazyl; D000432:Methanol