Caenorhabditis elegans as a model to determine fitness of antibiotic-resistant Salmonella enterica serovar typhimurium.
We used the ability of Salmonella enterica serovar Typhimurium to colonize the gut of Caenorhabditis elegans to measure the fitness costs imposed by antibiotic resistance mutations. The fitness costs determined in the nematode were similar to those measured in mice, validating its use as a simple host model to evaluate bacterial fitness.
Paulander
Wilhelm
W
Department of Bacteriology, Swedish Institute for Infectious Disease Control and Microbiology and Tumor Center, Karolinska Institute, Solna, Sweden.
Pennhag
Alexandra
A
Andersson
Dan I
DI
Maisnier-Patin
Sophie
S
D000818:Animals; D017173:Caenorhabditis elegans / Q000382:microbiology*; D004195:Disease Models, Animal; D024901:Drug Resistance, Multiple, Bacterial; D051379:Mice; D012481:Salmonella Infections, Animal; D012486:Salmonella typhimurium