Comparison of human herpes virus 8 related primary effusion lymphoma with human herpes virus 8 unrelated primary effusion lymphoma-like lymphoma on the basis of HIV: report of 2 cases and review of 212 cases in the literature.
BACKGROUND
Primary lymphomatous effusion is a rare lymphoma that arises in the body cavity and has a peculiar proliferative form, lacking a tumor. This primary lymphomatous effusion includes human herpes virus 8 (HHV8)-related primary effusion lymphoma (PEL) and HHV8-unrelated PEL-like lymphoma. We attempted to clarify the nature of the primary lymphomatous effusion.


METHODS
Using 'PEL' and 'body cavity-based lymphoma' (BCBL) as key words, reports written in English were collected from PubMed. Primary lymphomatous effusion was defined as BCBL with primary effusion and without tumor at onset. Adding our 2 PEL-like lymphoma cases, each case was studied as to the patients' and lymphomas' characteristics, therapy and survival time. Moreover, each item was compared among four groups according to the presence of HHV8 and HIV.


RESULTS
In 214 cases investigated, there was no difference in proliferation, but an apparent difference in age, gender, phenotype, effectiveness and prognosis among the four groups.


CONCLUSIONS
Both PEL and PEL-like lymphoma are thought to be characterized by a peculiar proliferation, regardless of the presence of HHV8. Dividing PEL or PEL-like lymphoma into two subgroups on the basis of HIV presentation might also be appropriate.
Kobayashi
Yutaka
Y
Division of Hematology and Oncology, Department of Internal Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan. kobataka@koto.kpu-m.ac.jp
Kamitsuji
Yuri
Y
Kuroda
Junya
J
Tsunoda
Sei
S
Uoshima
Nobuhiko
N
Kimura
Shinya
S
Wada
Katsuya
K
Matsumoto
Yosuke
Y
Nomura
Kenichi
K
Horiike
Shigeo
S
Shimazaki
Chihiro
C
Yoshikawa
Toshikazu
T
Taniwaki
Masafumi
M
D000368:Aged; D017809:Fatal Outcome; D005260:Female; D015658:HIV Infections / Q000150:complications*; D006566:Herpesviridae Infections / Q000150:complications*; D019288:Herpesvirus 8, Human; D006801:Humans; D008223:Lymphoma / Q000235:genetics / Q000473:pathology / Q000821:virology*; D010996:Pleural Effusion / Q000235:genetics / Q000473:pathology / Q000821:virology*