[Relevance of parasitological examinations for the clinical course, epidemiology and prevention of alveolar echinococcosis - experiences of more than two decades in Austria].
Alveolar echinococcosis has been known in Austria since 1854. At the beginning of the 20th century the Austrian researcher on echinococcosis, Adolf Posselt, has realized already the enormous medical relevance of serological tests for the diagnosis of alveolar echinococcosis as well as for preventive purposes. Since the beginning of the 1980ies a long-term study about the epidemiology and serodiagnosis of alveolar echinococcosis has started in the Department of Medical Parasitology of the Clinical Institute of Hygiene and Medical Microbiology of the University of Vienna. Today a highly sensitive enzyme-linked immunosorbent assay as well as a highly specific westernblot system are available for the serological diagnosis of human alveolar echinococcosis cases, for the serological monitoring of the disease as well as for seroepidemiological and preventive medical studies. In addition, molecular biological tools for the detection of E. multilocularis (as well as E. granulosus strain) specific DNA in surgical resected and bioptic materials complete our diagnostic spectrum of methods.
Auer
Herbert
H
Abteilung für Medizinische Parasitologie, Klinisches Institut für Hygiene und Medizinische Mikrobiologie, MUW, Wien, Austria. herbert.auer@meduniwien.ac.at
D000818:Animals; D001317:Austria; D015153:Blotting, Western; D019411:Clinical Laboratory Techniques; D004444:Echinococcosis, Hepatic / Q000175:diagnosis* / Q000453:epidemiology / Q000276:immunology; D048209:Echinococcus granulosus / Q000235:genetics / Q000276:immunology; D048210:Echinococcus multilocularis / Q000235:genetics / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D016133:Polymerase Chain Reaction; D011237:Predictive Value of Tests; D016036:Seroepidemiologic Studies; D012698:Serologic Tests