Anabolic steroid and gonadotropin releasing hormone analog combined treatment increased pubertal height gain and adult height in two children who entered puberty with short stature.
We studied the effect of gonadal suppression treatment in combination with anabolic steroid on pubertal height gain and adult height in two children who entered puberty with short stature. Patient 1 was a female with idiopathic short stature. She received combined treatment with an anabolic steroid (stanozolol) and a gonadotropin releasing hormone analog (leuprorelin acetate). Her pubertal height gain was 28.5 cm, which is greater than that in normal height girls (20-25 cm). Patient 2 was a male with Aarskog syndrome. Although his growth hormone (GH) secretion was normal, he received GH treatment. Since GH administration did not accelerate his growth, he received combined treatment with stanozolol and leuprorelin acetate. His pubertal height gain was 27.0 cm, which is greater than that observed in GH deficient boys treated with GH alone (21.9 cm). Combined treatment with stanozolol and leuprorelin acetate appears to be effective in increasing pubertal height gain and adult height in children who enter puberty with short stature.
Satoh
Mari
M
First Department of Pediatrics, Toho University School of Medicine, Japan. satomari@med.toho-u.ac.jp
Yokoya
Susumu
S
D000328:Adult; D000365:Age Determination by Skeleton; D000375:Aging / Q000502:physiology; D045930:Anabolic Agents / Q000627:therapeutic use*; D001827:Body Height / Q000187:drug effects / Q000502:physiology*; D015992:Body Mass Index; D001940:Breast / Q000254:growth & development; D004359:Drug Therapy, Combination; D005260:Female; D006128:Growth / Q000187:drug effects; D006728:Hormones / Q000097:blood; D006801:Humans; D016729:Leuprolide / Q000627:therapeutic use*; D008297:Male; D011627:Puberty / Q000502:physiology*; D013197:Stanozolol / Q000627:therapeutic use*; D013256:Steroids / Q000627:therapeutic use*; D013737:Testis / Q000254:growth & development
D045930:Anabolic Agents; D006728:Hormones; D013256:Steroids; D013197:Stanozolol; D016729:Leuprolide