Control of immune responses by immunoregulatory T cells.
Immunoregulatory T cells play a key role in modifying the immune responses to self antigens, tumor antigens, and pathogenic organisms. This review summarizes recent data on naturally occurring CD4(+) regulatory T cells that constitutively express CD25 (CD25(+)T(reg)). We examine the markers that can be used to differentiate these cells from effector T cells, what is known about their mode of action in controlling the activity of effector T cells, the antigenic specificity of CD25(+)T(reg), and their ability to survive and to be selected in vivo. We also summarize specific information on the role of CD25(+)T(reg) in controlling anti-tumor responses, an area were manipulation of this subset holds particular clinical promise.
Rudge
Geordie
G
Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, Victoria, 3010, Australia.
Gleeson
Paul A
PA
van Driel
Ian R
IR
D000818:Animals; D015415:Biomarkers / Q000032:analysis*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D049109:Cell Proliferation; D002470:Cell Survival; D000939:Epitopes / Q000276:immunology; D051858:Forkhead Transcription Factors / Q000235:genetics / Q000378:metabolism; D006801:Humans; D007111:Immunity, Cellular; D053645:Interleukin-2 Receptor alpha Subunit / Q000378:metabolism; D008213:Lymphocyte Activation; D008297:Male; D051379:Mice; D009369:Neoplasms / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
D015415:Biomarkers; D000939:Epitopes; C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors; D053645:Interleukin-2 Receptor alpha Subunit