Nonaqueous capillary electrophoretic behavior of 2-aryl propionic acids in the presence of an achiral ionic liquid. A chemometric approach.
Ionic liquids (ILs) appear really attractive as electrolyte additives in nonaqueous capillary electrophoresis (NACE). These salts may offer new possibilities of interactions to modulate analyte effective mobilities. The presence of 1-n-butyl-3-methylimidazolium bis(trifluoromethanesulfonyl)imide (BMIM NTf2) in acetonitrile/alcohol background electrolytes (BGEs) was investigated in this work. The aim of this study was to elucidate the influence of the IL concentration on the electrophoretic behavior of four arylpropionic acids and to identify the interactions between the analytes and the IL cation. The influence on mobility of the IL concentration, the nature and the proportion of the organic solvents, and the concentration of the ionic components of the BGE was first studied by a univariate approach. A four-factor D-optimal experimental design was then applied to provide a deeper insight into analyte interaction with IL cation present both free in BGE and adsorbed onto the capillary wall.
François
Yannis
Y
Laboratory of Electrochemistry and Analytical Chemistry, UMR CNRS 7575, ENSCP, 11 Rue Pierre et Marie Curie, 75231 Paris Cedex 05, France.
Varenne
Anne
A
Juillerat
Emilie
E
Servais
Anne-Catherine
AC
Chiap
Patrice
P
Gareil
Pierre
P
D002227:Carbazoles / Q000032:analysis / Q000737:chemistry; D004573:Electrolytes / Q000737:chemistry; D019075:Electrophoresis, Capillary / Q000379:methods*; D052578:Ionic Liquids / Q000737:chemistry*; D007660:Ketoprofen / Q000032:analysis / Q000737:chemistry; D008956:Models, Chemical; D015394:Molecular Structure; D015999:Multivariate Analysis; D009288:Naproxen / Q000032:analysis / Q000737:chemistry; D010666:Phenylpropionates / Q000032:analysis* / Q000737:chemistry; D011422:Propionates / Q000032:analysis* / Q000737:chemistry; D013237:Stereoisomerism; D013496:Suprofen / Q000032:analysis / Q000737:chemistry
D002227:Carbazoles; D004573:Electrolytes; D052578:Ionic Liquids; D010666:Phenylpropionates; D011422:Propionates; D009288:Naproxen; D007660:Ketoprofen; D013496:Suprofen; C007005:carprofen