Beyond blood sugar: the potential of NMR-based metabonomics for type 2 human diabetes, and the horse as a possible model.
Metabonomic analysis is a powerful tool for identifying and characterizing metabolic disorders, for example type 2 diabetes and the metabolic syndrome. Nuclear magnetic resonance (NMR) spectroscopy is an essential tool for such analysis, with special benefits. The review assesses the current status and potential of NMR-based metabonomics of type 2 diabetes. The horse is proposed as a possible model for studying this condition and disease. Some examples are shown of horse blood analyses by NMR.
Hodavance
Michael S
MS
Department of Chemistry, Princeton University, Princeton, NJ 08544, USA.
Ralston
Sarah L
SL
Pelczer
István
I
D000818:Animals; D001786:Blood Glucose; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism; D006736:Horses; D006801:Humans; D007328:Insulin / Q000097:blood; D008074:Lipoproteins / Q000097:blood; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D053858:Metabolic Networks and Pathways; D024821:Metabolic Syndrome / Q000378:metabolism; D023421:Models, Animal; D010949:Plasma / Q000737:chemistry
D001786:Blood Glucose; D007328:Insulin; D008074:Lipoproteins; D005947:Glucose