Increased prolactin in acute coronary syndromes as putative Co-activator of ADP-stimulated P-selectin expression.
Prolactin and leptin are newly recognized platelet co-stimulators due to enhancement of ADP-induced platelet aggregation. The aim of our study was to assess whether both hormones prolactin and leptin play a role as co-activators of platelet activation in patients with acute coronary syndromes. Twenty-one patients with acute coronary syndromes, 10 with stable angina pectoris and 10 controls were studied. Patients with acute coronary syndromes showed significantly higher prolactin and leptin values and a significant increased P-selectin expression on platelets compared to patients with stable angina pectoris or controls. However, patients with acute myocardial infarction as a subgroup of acute coronary syndromes showed the highest prolactin levels as well as ADP stimulated P-selectin expression. In the myocardial infarction subgroup prolactin values showed a significant correlation to ADP stimulated P-selectin expression on platelets (r (2)=0.41; p=0.025), whereas leptin was not correlated. Our data indicate an association between increased prolactin values and enhanced P-selectin expression on platelets in patients with acute coronary syndromes. Therefore, the stress hormone prolactin could be a co-stimulator of platelet activation in these patients. In contrast, the putative platelet activator leptin does not seem to play a major role in acute coronary syndromes.
Raaz
D
D
Medical Clinic 2, University Hospital Erlangen, Germany. dorette.raaz@med2.imed.uni-erlangen.de
Wallaschofski
H
H
Stumpf
C
C
Yilmaz
A
A
Cicha
I
I
Klinghammer
L
L
Daniel
W G
WG
Lohmann
T
T
Garlichs
C D
CD
D000244:Adenosine Diphosphate / Q000502:physiology*; D000368:Aged; D000789:Angina, Unstable / Q000097:blood; D001792:Blood Platelets / Q000378:metabolism; D003327:Coronary Disease / Q000378:metabolism*; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D020738:Leptin / Q000097:blood; D008297:Male; D009203:Myocardial Infarction / Q000097:blood; D019007:P-Selectin / Q000097:blood*; D011388:Prolactin / Q000097:blood*
D020738:Leptin; D019007:P-Selectin; D000244:Adenosine Diphosphate; D011388:Prolactin