title: Secretion and fluid transport mechanisms in the mammary gland: comparisons with the exocrine pancreas and the salivary gland.
abstract: Milk is a complex fluid composed of proteins, sugars, lipids and minerals, in addition to a wide variety of bioactive molecules including vitamins, trace elements and growth factors. The composition of these components reflects the integrated activities of distinct synthetic, secretion and transport processes found in mammary epithelial cells, and mirrors the differing nutritional and developmental requirements of mammalian neonates. Five general pathways have been described for secretion of milk components. With the exception of lipids, which are secreted a unique pathway, milk components are thought to be secreted by adaptations of pathways found in other secretory organs. However little is known about the molecular and cellular mechanisms that constitute these pathways or the physiological mechanisms by which they are regulated. Comparisons of current secretion and transport models in the mammary gland, exocrine pancreas and salivary gland indicate that significant differences exist between the mammary gland and other exocrine organs in how proteins and lipids are packaged and secreted, and how fluid is transported.
authors.affiliation: Department of Obstetrics and Gynecology, University of Colorado Health Sciences Center at Fitzsimons, Mail Stop 8309, P.O. Box 6511, Aurora, CO 80045, USA. jim.mcmanaman@uchsc.edu
authors.forename: James L
authors.initials: JL
authors.lastname: McManaman
authors.forename: Mary E
authors.initials: ME
authors.lastname: Reyland
authors.forename: Edwin C
authors.initials: EC
authors.lastname: Thrower
mesh_terms: D004573:Electrolytes / Q000378:metabolism; D005260:Female; D006801:Humans; D007774:Lactation; D050356:Lipid Metabolism; D042361:Mammary Glands, Human / Q000033:anatomy & histology / Q000378:metabolism*; D046790:Pancreas, Exocrine / Q000033:anatomy & histology / Q000378:metabolism; D012469:Salivary Glands / Q000033:anatomy & histology / Q000378:metabolism
chemical_list: D004573:Electrolytes