Human papillomavirus DNA in triple neoplasms of the cervix, perianus and ureter in one woman.
BACKGROUND
Multiple malignancies of the urogenital tract have been reported. We investigated the etiological role of human papillomavirus (HPV) in the pathogenesis of urogenital cancers.


METHODS
We present a case of cervical squamous carcinoma in a 64-year-old woman who subsequently developed Bowen's disease in the perianal skin and transitional cell carcinoma of the ureter. HPV DNA was detected in these tumor specimens using polymerase chain reaction.


CONCLUSIONS
The results strongly suggest that HPV may play a major role in the carcinogenesis of urogenital and perianal tumors.
Huang
Lee-Wen
LW
Department of Obstetrics and Gynecology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan, ROC. m002057@ms.skh.org.tw
Pan
Hun-Shan
HS
Lin
Yu-Hung
YH
Chou
Kuang-Yu
KY
D002294:Carcinoma, Squamous Cell / Q000453:epidemiology / Q000473:pathology / Q000821:virology*; D002295:Carcinoma, Transitional Cell / Q000453:epidemiology / Q000473:pathology / Q000821:virology*; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D006801:Humans; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary; D027383:Papillomaviridae; D030361:Papillomavirus Infections / Q000150:complications*; D014516:Ureteral Neoplasms / Q000453:epidemiology / Q000473:pathology / Q000821:virology*; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology / Q000473:pathology / Q000821:virology*
D004279:DNA, Viral