title: [Nitric oxide synthase in human intracardiac ganglia in the normal and ischemic myocardium].
abstract: Nitric oxide synthase (NOS) expression in human intracardiac ganglia was studied using two techniques--histochemical demonstration of NADPH-diaphorase and immunohistochemical staining for NOS. To detect the influence of coronary heart disease on NOS expression, hearts were studied in patients that died from heart failure (n = 8) and in persons that died in accidents (n = 3, control). It was found that human intracardiac neurons normally expressed mainly NOS1, and the proportion of these cells amounted to about 40%. A portion of neurons with low and moderate density of staining for NADPH-diaphorase was increased in ischemic myocardium, probably, due NOS2 induction.
authors.forename: A V
authors.initials: AV
authors.lastname: Shuklin
authors.forename: V N
authors.initials: VN
authors.lastname: Shvalev
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism; D005724:Ganglia / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D007527:Isoenzymes / Q000378:metabolism; D017202:Myocardial Ischemia / Q000378:metabolism* / Q000473:pathology; D009206:Myocardium / Q000201:enzymology* / Q000473:pathology; D009252:NADPH Dehydrogenase / Q000378:metabolism; D009474:Neurons / Q000378:metabolism* / Q000473:pathology; D019001:Nitric Oxide Synthase / Q000378:metabolism*; D052248:Nitric Oxide Synthase Type I / Q000378:metabolism
chemical_list: D007527:Isoenzymes; C496320:NOS1 protein, human; D019001:Nitric Oxide Synthase; D052248:Nitric Oxide Synthase Type I; D009252:NADPH Dehydrogenase; D000110:Acetylcholinesterase