title: Nonlinearities in rapid event-related fMRI explained by stimulus scaling.
abstract: Because of well-known nonlinearities in fMRI, responses measured with rapid event-related designs are smaller than responses measured with spaced designs. Surprisingly, no study to date has tested whether rapid designs also change the pattern of responses across different stimulus conditions. Here we report the results of such a test. We measured cortical responses to a flickering checkerboard at different contrasts using rapid and spaced event-related fMRI. The relative magnitude of responses across contrast conditions differed between rapid and spaced designs. Modeling the effect of the rapid design as a scaling of stimulus strength provided a good account of the data. The data were less well fit by a model that scaled the strength of responses. A similar stimulus scaling model has explained effects of neural adaptation, which suggests that adaptation may account for the observed difference between rapid and spaced designs. In a second experiment, we changed the stimulus in ways known to reduce neural adaptation and found much smaller differences between the two designs. Stimulus scaling provides a simple way to account for nonlinearities in event-related fMRI and relate data from rapid designs to data gathered using slower presentation rates.
authors.affiliation: UCLA Department of Psychology, Franz Hall 1282a, Los Angeles, CA 90095, USA.
authors.forename: Genevieve M
authors.initials: GM
authors.lastname: Heckman
authors.forename: Seth E
authors.initials: SE
authors.lastname: Bouvier
authors.forename: Valerie A
authors.initials: VA
authors.lastname: Carr
authors.forename: Erin M
authors.initials: EM
authors.lastname: Harley
authors.forename: Kristen S
authors.initials: KS
authors.lastname: Cardinal
authors.forename: Stephen A
authors.initials: SA
authors.lastname: Engel
mesh_terms: D000222:Adaptation, Physiological; D000328:Adult; D001921:Brain / Q000502:physiology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008959:Models, Neurological; D010775:Photic Stimulation