Human milk glycoproteins inhibit the adherence of Salmonella typhimurium to HeLa cells.
The ability of human milk, as well as its protein fractions, to inhibit the adhesion and invasion of Salmonella typhimurium to HeLa cells was investigated. The results revealed that milk secretory immunoglobulin A (sIgA) inhibited neither the adherence nor the bacterial invasion; however, free secretory component and lactoferrin inhibited the bacterial adhesion and interacted with several bacterial proteins. Our data indicated that glycoproteins such as free secretory component and lactoferrin could act as protective compounds against infant enteric diseases, possibly binding to bacterial surface and blocking adhesion, the primordial step of S. typhimurium infection.
Bessler
Heidi Christina
HC
Laboratório de Microbiologia, Departamento de Biologia Celular, Instituto de Ciências Biológicas, Universidade de Brasília, Brazil.
de Oliveira
Inaiara Rosa
IR
Giugliano
Loreny Gimenes
LG
D001422:Bacterial Adhesion; D006023:Glycoproteins / Q000502:physiology*; D006367:HeLa Cells; D006801:Humans; D007781:Lactoferrin / Q000502:physiology*; D008895:Milk, Human / Q000737:chemistry*; D012486:Salmonella typhimurium / Q000472:pathogenicity / Q000502:physiology*; D012635:Secretory Component / Q000502:physiology*
D006023:Glycoproteins; D012635:Secretory Component; D007781:Lactoferrin