Chaetominine, a cytotoxic alkaloid produced by endophytic Chaetomium sp. IFB-E015.
Chaetominine (1), an alkaloidal metabolite with a new framework, was characterized from the solid-substrate culture of Chaetomium sp. IFB-E015, an endophytic fungus on the apparently healthy Adenophora axilliflora leaves. Its structure was determined by a combination of its spectral data and single-crystal X-ray diffraction analysis, with its absolute configuration elucidated by Marfey's method. Chaetominine was more cytotoxic than 5-fluorouracil against the human leukemia K562 and colon cancer SW1116 cell lines. [structure: see text]
Jiao
Rui H
RH
Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, People's Republic of China.
Xu
Shu
S
Liu
Jun Y
JY
Ge
Hui M
HM
Ding
Hui
H
Xu
Chen
C
Zhu
Hai L
HL
Tan
Ren X
RX
D000903:Antibiotics, Antineoplastic / Q000302:isolation & purification / Q000494:pharmacology*; D000964:Antimetabolites, Antineoplastic / Q000494:pharmacology; D029422:Campanulaceae / Q000382:microbiology; D045744:Cell Line, Tumor; D002597:Chaetomium / Q000737:chemistry*; D002942:Circular Dichroism; D003110:Colonic Neoplasms / Q000188:drug therapy / Q000473:pathology; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D005472:Fluorouracil / Q000494:pharmacology; D006801:Humans; D026121:Indole Alkaloids / Q000302:isolation & purification / Q000494:pharmacology*; D020014:K562 Cells; D009682:Magnetic Resonance Spectroscopy; D018515:Plant Leaves / Q000382:microbiology; D021241:Spectrometry, Mass, Electrospray Ionization; D013778:Tetrazolium Salts; D013844:Thiazoles
D000903:Antibiotics, Antineoplastic; D000964:Antimetabolites, Antineoplastic; D026121:Indole Alkaloids; D013778:Tetrazolium Salts; D013844:Thiazoles; C522312:chaetominine; C022616:thiazolyl blue; D005472:Fluorouracil