The role of actomyosin and the microtubular network in both the immunological synapse and T cell activation.
The formation of immunological synapses between T cells and APCs, as well as the functions associated with this structure, like cytokine secretion and the lysis of infected cells, are critical processes in the immune response. The T cell cytoskeleton is involved in these activities and this has been the subject of numerous studies in recent years. Although the importance of the T cell actin network is evident, the participation of microtubules and myosin motors in the formation of immunological synapses and T cell effector functions has also been assessed. This review provides an update on the role of cytoskeletal networks and related molecules in the activation of T lymphocytes.
Rey
Mercedes
M
Servicio de Inmunologia, Hospital Universitario de La Princesa, C/ Diego de Leon, 62, 28006-Madrid, Spain.
Sanchez-Madrid
Francisco
F
Valenzuela-Fernandez
Agustin
A
D008841:Actin Cytoskeleton / Q000502:physiology; D000205:Actomyosin / Q000502:physiology*; D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology; D016207:Cytokines / Q000378:metabolism; D005089:Exocytosis; D006801:Humans; D008213:Lymphocyte Activation; D008870:Microtubules / Q000502:physiology*; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000276:immunology* / Q000648:ultrastructure; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology
D016207:Cytokines; D000205:Actomyosin