Corpuscular antigenic microarray for the serodiagnosis of blood culture-negative endocarditis.
Blood culture-negative endocarditis is due to fastidious bacteria, including Coxiella burnetii and Bartonella spp. Diagnosis of such infection relies on serology and microimmunofluorescence is therefore the reference method. We developed a multiplex serology test featuring automatic incubation and reading and incorporating internal controls. Preliminary results indicate that this new serologic test is valuable for the rapid, automated serological diagnosis of blood culture-negative endocarditis.
Samson
Laurent
L
Unité des Rickettsies, CNRS UMR 6020, IFR 48, Faculté de médecine, Université de la Méditerranée, 27 Bd Jean Moulin, 13385 Marseille Cedex 05, France.
Drancourt
Michel
M
Casalta
Jean-Paul
JP
Raoult
Didier
D
D000942:Antigens, Bacterial / Q000276:immunology; D001474:Bartonella Infections / Q000097:blood / Q000175:diagnosis*; D016997:Coxiella burnetii; D004697:Endocarditis, Bacterial / Q000097:blood / Q000175:diagnosis*; D005455:Fluorescent Antibody Technique; D006801:Humans; D020411:Oligonucleotide Array Sequence Analysis; D011778:Q Fever / Q000097:blood / Q000175:diagnosis*; D012698:Serologic Tests / Q000379:methods*
D000942:Antigens, Bacterial