title: Absence of angiogenic genes modification in Italian ALS patients.
abstract: To investigate the role of vascular endothelial growth factor (VEGF) and angiogenin (ANG) as genetic determinants in the susceptibility to sporadic ALS in Italian patients. VEGF genotype and haplotype analysis revealed no association between any variants and the risk of ALS. Regarding ANG gene, no mutation was detected and the rs11701 polymorphism, previously described as associated with ALS, was not differently distributed between patients and controls. Overall, our data argue against the hypothesis of both genes as risk factors for motoneuron neurodegeneration, at least in an Italian population.
authors.affiliation: Dino Ferrari Centre, Department of Neurological Sciences, University of Milan, IRCCS Foundation Ospedale Maggiore Policlinico Mangiagalli and Regina Elena, Milan, Italy. roberto.delbo@unimi.it
authors.forename: Roberto
authors.initials: R
authors.lastname: Del Bo
authors.forename: Marina
authors.initials: M
authors.lastname: Scarlato
authors.forename: Serena
authors.initials: S
authors.lastname: Ghezzi
authors.forename: Filippo
authors.initials: F
authors.lastname: Martinelli-Boneschi
authors.forename: Stefania
authors.initials: S
authors.lastname: Corti
authors.forename: Federica
authors.initials: F
authors.lastname: Locatelli
authors.forename: Domenico
authors.initials: D
authors.lastname: Santoro
authors.forename: Alessandro
authors.initials: A
authors.lastname: Prelle
authors.forename: Chiara
authors.initials: C
authors.lastname: Briani
authors.forename: Martina
authors.initials: M
authors.lastname: Nardini
authors.forename: Gabriele
authors.initials: G
authors.lastname: Siciliano
authors.forename: Michelangelo
authors.initials: M
authors.lastname: Mancuso
authors.forename: Luigi
authors.initials: L
authors.lastname: Murri
authors.forename: Nereo
authors.initials: N
authors.lastname: Bresolin
authors.forename: Giacomo Pietro
authors.initials: GP
authors.lastname: Comi
mesh_terms: D000690:Amyotrophic Lateral Sclerosis / Q000453:epidemiology / Q000235:genetics*; D006801:Humans; D007558:Italy / Q000453:epidemiology; D009154:Mutation / Q000235:genetics*; D011110:Polymorphism, Genetic; D012259:Ribonuclease, Pancreatic / Q000172:deficiency* / Q000235:genetics*; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics
chemical_list: D042461:Vascular Endothelial Growth Factor A; C046366:angiogenin; D012259:Ribonuclease, Pancreatic