[The effect of the time of death on the reactivity of rat caudal artery regulated by PHE with a simultaneous use of NOS, CG and COX inhibitors. Part II].
The investigations were conducted on PHE-perfused rat caudal arteries in four different time groups. Inhibitors of NO synthase, CG and COX were used simultaneously to explain the effect of the time of death on biochemical mechanisms controlling the functioning of metabotropic receptors. The authors demonstrated that using the NO synthase inhibitor improved post mortem arterial reactivity, what indicated maintained endogenous NO synthesis after death. The CG inhibitor also improved arterial reactivity and intracellular Ca++ ion concentration. No improvement was seen in arterial reactivity when COX was employed in the study.
Bloch-Bogusławska
Elzbieta
E
Katedry i Zakładu Medycyny Sadowej UMK w Toruniu CM w Bydgoszczy.
D000818:Animals; D017209:Apoptosis / Q000187:drug effects / Q000502:physiology*; D001158:Arteries / Q000187:drug effects / Q000378:metabolism*; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology*; D006162:Guanylate Cyclase / Q000037:antagonists & inhibitors*; D007425:Intracellular Membranes / Q000378:metabolism; D008297:Male; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors*; D010656:Phenylephrine / Q000494:pharmacology; D011180:Postmortem Changes; D051381:Rats; D017208:Rats, Wistar; D013623:Tail / Q000098:blood supply; D013997:Time Factors; D014662:Vasoconstrictor Agents / Q000494:pharmacology
D016861:Cyclooxygenase Inhibitors; D014662:Vasoconstrictor Agents; D010656:Phenylephrine; D019001:Nitric Oxide Synthase; D006162:Guanylate Cyclase