title: Facilitation of performance in a working memory task with rTMS stimulation of the precuneus: frequency- and time-dependent effects.
abstract: Although improvements in performance due to TMS have been demonstrated with some cognitive tasks, performance improvement has not previously been demonstrated with working memory tasks. In the present study, a delayed match-to-sample task was used in which repetitive TMS (rTMS) at 1, 5, or 20 Hz was applied to either left dorsolateral prefrontal or midline parietal cortex during the retention (delay) phase of the task. Only 5 Hz stimulation to the parietal site resulted in a significant decrease in reaction time (RT) without a corresponding decrease in accuracy. This finding was replicated in a second experiment, in which 5 Hz rTMS at the parietal site was applied during the retention phase or during presentation of the recognition probe. Significant speeding of RT occurred in the retention phase but not the probe phase. This finding suggests that TMS may improve working memory performance, in a manner that is specific to the timing of stimulation relative to performance of the task, and to stimulation frequency.
authors.affiliation: Brain Stimulation and Therapeutic Modulation Division, New York State Psychiatric Institute, New York, NY 10032, USA. luberbr@pi.cpmc.columbia.edu
authors.forename: B
authors.initials: B
authors.lastname: Luber
authors.forename: L H
authors.initials: LH
authors.lastname: Kinnunen
authors.forename: B C
authors.initials: BC
authors.lastname: Rakitin
authors.forename: R
authors.initials: R
authors.lastname: Ellsasser
authors.forename: Y
authors.initials: Y
authors.lastname: Stern
authors.forename: S H
authors.initials: SH
authors.lastname: Lisanby
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D002540:Cerebral Cortex / Q000502:physiology / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D005260:Female; D006801:Humans; D008297:Male; D008570:Memory, Short-Term / Q000528:radiation effects*; D009483:Neuropsychological Tests; D011930:Reaction Time / Q000528:radiation effects; D012153:Retention, Psychology / Q000528:radiation effects; D013997:Time Factors; D050781:Transcranial Magnetic Stimulation