[Stimulation with 0,3 mg recombinant human thyrotropin (rhTSH) increases the effect of 131I therapy in patients with nontoxic nodular goiter. A prospective, randomized, double-blind trial--secondary publication].
In a randomized, double-blind, placebo-controlled trial, 57 patients with nontoxic nodular goiter were stimulated with either 0.3 mg recombinant human thyrotropin (rhTSH) or placebo before radioactive iodine 131I therapy. After one year the goiter reduction had improved by 35% compared to conventional 131I therapy. The difference was most pronounced in patients with a large goiter. Adverse effects, including development of permanent hypothyroidism, were significantly more frequent in the rhTSH group. Patient satisfaction was high and uninfluenced by the use of rhTSH.
Nielsen
Viveque Egsgaard
VE
Odense Universitetshospital, Endokrinologisk og Nuklearmedicinsk Afdeling, Odense C. viveque.egsgaard@ouh.fyns-amt.dk
Bonnema
Steen Joop
SJ
Jørgensen
Henrik Boel
HB
Grupe
Peter
P
Hegedüs
Laszlo
L