title: Enhancement of water-solubility and bioactivity of paclitaxel using modified cyclodextrins.
abstract: We investigated the aqueous solubility of paclitaxel using 11 kinds of cyclodextrins (CDs) and the bioactivity of the paclitaxel-CD inclusion complex. 2,6-Dimethyl beta-cyclodextrin was the most effective and its solubility was 2.3 mM in a 0.1 M 2,6-dimethyl beta-cyclodextrin aqueous solution. The inclusion complex of paclitaxel and 2,6-dimethyl beta-cyclodextrin had a 1.23-fold polymerization activity as paclitaxel in a tubulin assay.
authors.affiliation: Department of Life Science, Okayama University of Science, 1-1 Ridai-cho, Okayama 700-0005, Japan. hamada@das.ous.ac.jp
authors.forename: Hiroki
authors.initials: H
authors.lastname: Hamada
authors.forename: Kohji
authors.initials: K
authors.lastname: Ishihara
authors.forename: Noriyoshi
authors.initials: N
authors.lastname: Masuoka
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Mikuni
authors.forename: Nobuyoshi
authors.initials: N
authors.lastname: Nakajima
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry; D003505:Cyclodextrins / Q000737:chemistry*; D004355:Drug Stability; D017239:Paclitaxel / Q000737:chemistry*; D012995:Solubility; D012996:Solutions; D014867:Water / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D003505:Cyclodextrins; D012996:Solutions; D014867:Water; D017239:Paclitaxel