Immune reconstitution inflammatory syndrome in the first year after HAART: influence on long-term clinical outcome.
Little is known about the effect of immune reconstitution inflammatory syndrome (IRIS) on the long-term clinical outcome. Of 52 opportunistic infections (OI) occurring within one year after the start of HAART in 387 HIV patients, 33 (63%) were classified as having IRIS. The patients with IRIS showed no significant difference in the AIDS event-free survival curve compared with the matched control group without OI and in contrast to non-IRIS OI.
Park
Wan Beom
WB
Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.
Choe
Pyoeng Gyun
PG
Jo
Jae Hyun
JH
Kim
Sung-Han
SH
Bang
Ji Hwan
JH
Kim
Hong Bin
HB
Kim
Nam Joong
NJ
Oh
Myoung-Don
MD
Choe
Kang Won
KW
D017088:AIDS-Related Opportunistic Infections / Q000276:immunology; D000328:Adult; D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects*; D018791:CD4 Lymphocyte Count; D005260:Female; D015658:HIV Infections / Q000188:drug therapy*; D006801:Humans; D007154:Immune System Diseases / Q000276:immunology*; D053208:Kaplan-Meier Estimate; D008297:Male; D012189:Retrospective Studies; D013577:Syndrome; D016896:Treatment Outcome