Antibacterial and anticoagulant activities of coumarins isolated from the flowers of Magydaris tomentosa.
The phytochemical investigation of the acetone and methanol extracts of the flowers of Magydaris tomentosa (Desf.) DC afforded six known coumarins as well as (+)-meranzin hydrate (7), not previously reported as a natural product. The antibacterial activity of umbelliprenin (1), osthol (2), imperatorin (3), citropten (4) and (+)-meranzin hydrate (7) was tested against Gram-positive and Gram-negative bacteria. All coumarins (1-7) isolated in this study inhibited growth of all bacterial strains tested (MIC between 16 and 256 microg/mL), the most active being imperatorin (3) (MICs between 32 and 128 microg/mL) and citropten (4) (MICs between 16 and 256 microg/mL). The anticoagulant activity of compounds 1-4 and 7 was also evaluated.
Rosselli
Sergio
S
Dipartimento di Chimica Organica, Università degli Studi di Palermo, Palermo, Italy.
Maggio
Antonella
A
Bellone
Gabriella
G
Formisano
Carmen
C
Basile
Adriana
A
Cicala
Carla
C
Alfieri
Alessio
A
Mascolo
Nicola
N
Bruno
Maurizio
M
D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000925:Anticoagulants / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D019661:Apiaceae / Q000737:chemistry*; D003374:Coumarins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D035264:Flowers / Q000737:chemistry; D008297:Male; D008826:Microbial Sensitivity Tests; D051381:Rats; D017208:Rats, Wistar
D000900:Anti-Bacterial Agents; D000925:Anticoagulants; D003374:Coumarins