title: Cytotoxic terpene hydroperoxides from the aerial parts of Aster spathulifolius.
abstract: Three new sesquiterpene hydroperoxides, 1-[3-(2-hydroperoxy-3-methylbut-3-en)-4-hydroxyphenyl]ethanone (2), 7beta-hydroperoxy-eudesma-11-en-4-ol (3), and 7alpha-hydroperoxymanool (4), together with three known compounds, germacrone (1), ent-germacra-4(15),5,10(14)-trien-1alpha-ol (5) and teucdiol A (6) were isolated from the aerial parts of Aster spathulifolius (Compositae). Their structures were characterized using chemical and spectroscopic methods. The isolated compounds were tested for their cytotoxicity against five human tumor cell lines in vitro using a SRB method. The two new compounds, 3 and 4, showed moderate cytotoxicity against human cancer cells with ED50 values ranging from 0.24 to 13.27 microg/mL.
authors.affiliation: Natural Products Laboratory, College of Pharmacy, Sungkyunkwan University, Suwon 440-746, Korea.
authors.forename: Sung Ok
authors.initials: SO
authors.lastname: Lee
authors.forename: Sang Zin
authors.initials: SZ
authors.lastname: Choi
authors.forename: Sang Un
authors.initials: SU
authors.lastname: Choi
authors.forename: Gun Hee
authors.initials: GH
authors.lastname: Kim
authors.forename: Young Choong
authors.initials: YC
authors.lastname: Kim
authors.forename: Kang Ro
authors.initials: KR
authors.lastname: Lee
mesh_terms: D031173:Aster Plant / Q000737:chemistry*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity; D006801:Humans; D006861:Hydrogen Peroxide / Q000737:chemistry / Q000633:toxicity*; D007723:Korea; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008518:Medicine, East Asian Traditional; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular / Q000379:methods; D010545:Peroxides / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity; D035261:Plant Components, Aerial / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity; D045788:Sesquiterpenes, Germacrane / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods; D013329:Structure-Activity Relationship; D013729:Terpenes / Q000737:chemistry / Q000633:toxicity*
chemical_list: C517307:7-hydroperoxyeudesma-11-en-4-ol; C517308:7-hydroperoxymanool; D004224:Diterpenes; D010545:Peroxides; D010936:Plant Extracts; D012717:Sesquiterpenes; D045788:Sesquiterpenes, Germacrane; D013729:Terpenes; C048393:germacrone; D006861:Hydrogen Peroxide