title: Fracture rate in children with cerebral palsy.
abstract: OBJECTIVE
  To determine the prevalence of previous fracture, the rate of fracture over time and associated risk factors for fracture in children with moderate or severe cerebral palsy (CP).
  
  
  METHODS
  Three hundred and sixty-four children with moderate-to-severe motor impairment (Gross Motor Function Classification System III, IV and V) enrolled in a multi-centre, region-based longitudinal study of growth, nutrition and health. Of these, 297 had baseline fracture information and 261 children had at least one follow-up assessment. Median duration of follow-up was 1.6 years, for over 600 person-years of follow-up.
  
  
  RESULTS
  Forty-six (15.5%) children reported 62 previous fractures at baseline assessment. Children with a history of fractures at baseline were older (mean age 11.9 vs. 8.9 years, p<0.0001) and had greater body fat (triceps z-score -0.01 vs. -0.68, p=0.0003) than children with no previous fracture. Twenty children (6.7%) reported 24 fractures during the follow-up period. Factors associated with risk of fracture during the follow-up period were higher body fat (p=0.03), gastrostomy use (p=0.05) and previous fracture (p=0.10). Based on 24 fractures in 604.5 person-years of follow-up, the rate of fracture was 4.0 per hundred children (4.0%) per year. For children with a history of fracture at baseline, the fracture rate was 7.0% per year; for children with gastrostomy, 6.8% per year; and for children with high triceps skinfold, 9.7% per year.
  
  
  CONCLUSIONS
  Children with moderate or severe CP are at high risk for fracture. Children with greater body fat, feeding gastrostomy and prior history of fracture are at highest risk and may benefit most from intervention. Further longitudinal study and clinical trials in children with CP are needed to better understand the factors contributing to fracture risk in this population and the best methods of prevention and treatment.
authors.affiliation: Department of Pediatrics, University of Virginia, Charlottesville, VA 22903, USA. rds8z@virginia.edu
authors.forename: Richard D
authors.initials: RD
authors.lastname: Stevenson
authors.forename: Mark
authors.initials: M
authors.lastname: Conaway
authors.forename: John W
authors.initials: JW
authors.lastname: Barrington
authors.forename: Sara L
authors.initials: SL
authors.lastname: Cuthill
authors.forename: Gordon
authors.initials: G
authors.lastname: Worley
authors.forename: Richard C
authors.initials: RC
authors.lastname: Henderson
mesh_terms: D000293:Adolescent; D000328:Adult; D002547:Cerebral Palsy / Q000150:complications* / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D005260:Female; D050723:Fractures, Bone / Q000453:epidemiology* / Q000209:etiology*; D006801:Humans; D007223:Infant; D008297:Male; D015995:Prevalence; D012307:Risk Factors; D012720:Severity of Illness Index; D014481:United States / Q000453:epidemiology