GLUT1 is not the primary binding receptor but is associated with cell-to-cell transmission of human T-cell leukemia virus type 1.
GLUT1 has recently been suggested to be a binding receptor for human T-cell leukemia virus type 1 (HTLV-1). We used a novel, short-term assay to define the role of GLUT1 in cell-to-cell transmission. Although increasing cell surface levels of GLUT1 enhanced HTLV-I transfer, efficient virus spread correlated largely with heparan sulfate proteoglycan (HSPG) expression on target cells. Moreover, since activated CD4+ T cells and cord blood lymphocytes that are susceptible to HTLV-1 infection expressed undetectable levels of surface GLUT1, these results indicate that GLUT1 and HSPGs are important for efficient cell-to-cell transmission of HTLV-1 but raise concerns on the role of GLUT1 as the HTLV-1 primary binding receptor.
Takenouchi
Norihiro
N
Viral Immunology Section, Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20982, USA.
Jones
Kathryn S
KS
Lisinski
Ivonne
I
Fugo
Kazunori
K
Yao
Karen
K
Cushman
Samuel W
SW
Ruscetti
Francis W
FW
Jacobson
Steven
S
D051272:Glucose Transporter Type 1 / Q000378:metabolism*; D015490:HTLV-I Infections / Q000635:transmission; D015368:Human T-lymphotropic virus 1 / Q000378:metabolism* / Q000472:pathogenicity; D006801:Humans; D015458:Leukemia, T-Cell / Q000503:physiopathology / Q000821:virology; D011991:Receptors, Virus / Q000378:metabolism*; D014771:Virion / Q000502:physiology*
D051272:Glucose Transporter Type 1; D011991:Receptors, Virus