title: Chemical composition and in vitro antifungal and antioxidant activity of the essential oil and methanolic extract of Teucrium sauvagei Le Houerou.
abstract: The chemical composition and the in vitro antifungal and antioxidant activity of the essential oil and the methanolic leaf extracts of Teucrium sauvagei Le Houerou, an endemic medicinal plant growing in Tunisia, have been studied. More than 35 constituents having an abundance >or=0.2% were identified in the oil. beta-Eudesmol, T-cadinol, alpha-thujene, gamma-cadinene, and sabinene were the prevalent constituents. Results of the antifungal activity tests indicated that the methanolic extract inhibited the in vitro growth of seven dermatophytes, whereas the essential oil showed average inhibition against only three dermatophytes. In vitro antioxidant properties of the essential oil and the methanolic extract were determined by DPPH (2,2-diphenyl-1-picrylhydrazyl) and ABTS (2,2'-azinobis(3-ethylbenzothiazoline-6-sulphonic acid)) assays and compared to those of the synthetic antioxidant Trolox. Due to their antifungal and antioxidant properties, the essential oil and the methanolic extract of T. sauvagei may be of use as natural preservative ingredients in food and/or pharmaceutical industries.
authors.affiliation: Faculté de Pharmacie, Laboratoire des Maladies Transmissibles et Substances Biologiquement Actives, 5000 Monastir, Tunisia.
authors.forename: K Bel Hadj
authors.initials: KB
authors.lastname: Salah
authors.forename: M A
authors.initials: MA
authors.lastname: Mahjoub
authors.forename: J P
authors.initials: JP
authors.lastname: Chaumont
authors.forename: L
authors.initials: L
authors.lastname: Michel
authors.forename: J
authors.initials: J
authors.lastname: Millet-Clerc
authors.forename: I
authors.initials: I
authors.lastname: Chraeif
authors.forename: S
authors.initials: S
authors.lastname: Ammar
authors.forename: Z
authors.initials: Z
authors.lastname: Mighri
authors.forename: M
authors.initials: M
authors.lastname: Aouni
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry* / Q000633:toxicity; D000975:Antioxidants / Q000737:chemistry* / Q000633:toxicity; D052160:Benzothiazoles; D001713:Biphenyl Compounds; D002839:Chromans / Q000633:toxicity; D005658:Fungi / Q000187:drug effects; D008401:Gas Chromatography-Mass Spectrometry; D006834:Hydrazines; D009822:Oils, Volatile / Q000737:chemistry* / Q000633:toxicity; D010851:Picrates; D010936:Plant Extracts / Q000737:chemistry* / Q000633:toxicity; D018515:Plant Leaves / Q000737:chemistry*; D013451:Sulfonic Acids; D031367:Teucrium / Q000737:chemistry* / Q000633:toxicity; D014416:Tunisia
chemical_list: D000935:Antifungal Agents; D000975:Antioxidants; D052160:Benzothiazoles; D001713:Biphenyl Compounds; D002839:Chromans; D006834:Hydrazines; D009822:Oils, Volatile; D010851:Picrates; D010936:Plant Extracts; D013451:Sulfonic Acids; C040618:teucrium extract; C002502:2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid; C004931:1,1-diphenyl-2-picrylhydrazyl; C010643:6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid