title: Aggression and quantitative MRI measures of caudate in patients with chronic schizophrenia or schizoaffective disorder.
abstract: Caudate dysfunction is implicated in schizophrenia. However, little is known about the relationship between aggression and caudate volumes. Forty-nine patients received magnetic resonance imaging scanning in a double-blind treatment study in which aggression was measured. Caudate volumes were computed using a semiautomated method. The authors measured aggression with the Overt Aggression Scale and the Positive and Negative Syndrome Scale. Larger caudate volumes were associated with greater levels of aggression. The relationship between aggression and caudate volumes may be related to the iatrogenic effects of long-term treatment with typical antipsychotic agents or to a direct effect of schizophrenic processes on the caudate.
authors.affiliation: Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA. Hoptman@nki.rfmh.org
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Hoptman
authors.forename: Jan
authors.initials: J
authors.lastname: Volavka
authors.forename: Pál
authors.initials: P
authors.lastname: Czobor
authors.forename: Guido
authors.initials: G
authors.lastname: Gerig
authors.forename: Miranda
authors.initials: M
authors.lastname: Chakos
authors.forename: Joseph
authors.initials: J
authors.lastname: Blocher
authors.forename: Leslie L
authors.initials: LL
authors.lastname: Citrome
authors.forename: Brain
authors.initials: B
authors.lastname: Sheitman
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Lindenmayer
authors.forename: Jeffrey A
authors.initials: JA
authors.lastname: Lieberman
authors.forename: Robert M
authors.initials: RM
authors.lastname: Bilder
mesh_terms: D000328:Adult; D000374:Aggression / Q000502:physiology*; D002421:Caudate Nucleus / Q000473:pathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D011618:Psychotic Disorders / Q000473:pathology* / Q000503:physiopathology*; D012559:Schizophrenia / Q000473:pathology* / Q000503:physiopathology*