title: Bone regeneration in dehiscence-type defects at chemically modified (SLActive) and conventional SLA titanium implants: a pilot study in dogs.
abstract: OBJECTIVE
  The aim of the present study was to evaluate bone regeneration in dehiscence-type defects at titanium implants with chemically modified (mod) and conventional sand-blasted/acid-etched (SLA) surfaces.
  
  
  METHODS
  Standardized buccal dehiscence defects (height: 3 mm, width: 3 mm) were surgically created following implant site preparation in both the upper and lower jaws of four beagle dogs. modSLA and SLA implants were inserted bilaterally according to a split-mouth design. The animals were sacrificed after 2 and 12 weeks (n=2 animals each). Dissected blocks were processed for histomorphometrical analysis: defect length, new bone height (NBH), percent linear fill (PLF), percent of bone-to-implant contact (BIC-D) and area of new bone fill (BF).
  
  
  RESULTS
  Wound healing at SLA implants was predominantly characterized by the formation of a dense connective tissue at 2 and 12 weeks, without significant increases in mean NBH, PLF, BIC-D or BF values. In contrast, modSLA implants exhibited a complete defect fill at 12 weeks following implant placement. In particular, histomorphometrical analysis revealed the following mean values at 12 weeks: NBH (3.2+/-0.3 mm), PLF (98%), BIC-D (82%) and BF (2.3+/-0.4 mm(2)).
  
  
  CONCLUSIONS
  Within the limits of the present study, it was concluded that modSLA titanium surfaces may promote bone regeneration in acute-type buccal dehiscence defects at submerged implants.
authors.affiliation: Department of Oral Surgery, Heinrich Heine University, Düsseldorf, Germany. info@frank-schwarz.de
authors.forename: Frank
authors.initials: F
authors.lastname: Schwarz
authors.forename: Monika
authors.initials: M
authors.lastname: Herten
authors.forename: Martin
authors.initials: M
authors.lastname: Sager
authors.forename: Marco
authors.initials: M
authors.lastname: Wieland
authors.forename: Michel
authors.initials: M
authors.lastname: Dard
authors.forename: Jürgen
authors.initials: J
authors.lastname: Becker
mesh_terms: D000134:Acid Etching, Dental; D020906:Air Abrasion, Dental; D016301:Alveolar Bone Loss / Q000473:pathology / Q000503:physiopathology*; D000539:Alveolar Process / Q000473:pathology / Q000503:physiopathology; D000818:Animals; D001861:Bone Regeneration / Q000502:physiology*; D016723:Bone Remodeling / Q000502:physiology; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D003238:Connective Tissue / Q000473:pathology / Q000503:physiopathology; D003758:Dental Implantation, Endosseous / Q000379:methods; D015921:Dental Implants; D003764:Dental Materials / Q000737:chemistry*; D004285:Dogs; D016348:Osseointegration / Q000502:physiology; D010012:Osteogenesis / Q000502:physiology; D010865:Pilot Projects; D011897:Random Allocation; D013499:Surface Properties; D013997:Time Factors; D014025:Titanium / Q000737:chemistry*
chemical_list: D020099:Coated Materials, Biocompatible; D015921:Dental Implants; D003764:Dental Materials; D014025:Titanium