Torsades de pointes with a severely prolonged QT interval induced by an initial low dose sotalol intake.
Many drugs, including sotalol, have been implicated in prolonging QT interval and triggering torsades de pointes, a potentially fatal ventricular arrhythmia, especially during chronic therapy or in case of acute high dose toxicity. We report here a case with a severely prolonged QT interval and torsades de pointes after an initial intake of low dose sotalol (80 mg), indicating a probable inherent individual oversensitivity to sotalol.
Yalta
Kenan
K
Turgut
Okan
O
Yilmaz
Ahmet
A
Yilmaz
M Birhan
MB
Kendirlioglu
Omer
O
Karadas
Filiz
F
D000328:Adult; D000889:Anti-Arrhythmia Agents / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008133:Long QT Syndrome / Q000139:chemically induced*; D013015:Sotalol / Q000009:adverse effects*; D016171:Torsades de Pointes / Q000139:chemically induced*
D000889:Anti-Arrhythmia Agents; D013015:Sotalol