Osteoinduction with COLLOSS, COLLOSS E, and GFm.
This study provided data relevant to three major goals. It confirmed that both COLLOSS and COLLOSS E contain osteo- and chondro-inductive BMPs as shown by their ability to produce new bone in an ectopic location in rats. Second, based on the area of bone produced in standardized implant sections by osteoinductive growth factors in GFm, COLLOSS , and COLLOSS E and their respective collagenous carrier matrices, the study showed that COLLOSS was 0.1, and COLLOSS E 0.3 time as potent as 10 microg of GFm. Finally, the study showed that ordinary and accelerated endochondral bone formation were more frequent in response to GFm than to COLLOSS and COLLOSS E, whereas membranous bone formation was more frequent in response to COLLOSS E than to COLLOSS or GFm.
Huffer
W E
WE
Department of Pathology, University of Colorado Health Sciences Center, Denver, CO, USA.
Benedict
J J
JJ
Rettenmaier
R
R
Briest
A
A
D000818:Animals; D019485:Bone Morphogenetic Proteins / Q000737:chemistry* / Q000378:metabolism; D018786:Bone Substitutes / Q000737:chemistry*; D001842:Bone and Bones / Q000378:metabolism*; D002417:Cattle; D019902:Chondrocytes / Q000378:metabolism; D003094:Collagen / Q000737:chemistry*; D006736:Horses; D051457:Hyaline Cartilage / Q000378:metabolism; D020007:Implants, Experimental; D016348:Osseointegration; D010011:Osteocytes / Q000378:metabolism; D010012:Osteogenesis; D013552:Swine
D019485:Bone Morphogenetic Proteins; D018786:Bone Substitutes; C515502:COLLOSS E; C487179:Colloss; D003094:Collagen