title: Manic behaviour induced by deep-brain stimulation in Parkinson's disease: evidence of substantia nigra implication?
abstract: We report the case of a patient who had benefited from bilateral subthalamic nucleus deep brain stimulation for Parkinson's disease and who presented acute and reproducible manic behaviour when stimulated mainly in the substantia nigra. A positron emission tomography scan showed an activation of the right dorsolateral prefrontal and inferior temporal cortex, the left anterior cingulate cortex and a deactivation of the left insula. This suggests that changes in cortical activation related to mania are subcortically driven, involving notably the substantia nigra.
authors.affiliation: Univ Clermont 1, UFR Médecine, Clermont-Ferrand, France. mulla@chu-clermontferrand.fr
authors.forename: M
authors.initials: M
authors.lastname: Ulla
authors.forename: S
authors.initials: S
authors.lastname: Thobois
authors.forename: J-J
authors.initials: JJ
authors.lastname: Lemaire
authors.forename: A
authors.initials: A
authors.lastname: Schmitt
authors.forename: P
authors.initials: P
authors.lastname: Derost
authors.forename: E
authors.initials: E
authors.lastname: Broussolle
authors.forename: P-M
authors.initials: PM
authors.lastname: Llorca
authors.forename: F
authors.initials: F
authors.lastname: Durif
mesh_terms: D001714:Bipolar Disorder / Q000209:etiology*; D046690:Deep Brain Stimulation / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008875:Middle Aged; D010300:Parkinson Disease / Q000628:therapy*; D013378:Substantia Nigra / Q000502:physiology*; D020531:Subthalamic Nucleus / Q000502:physiology