First international consensus on the methodology of lymphangiogenesis quantification in solid human tumours.
The lymphatic system is the primary pathway of metastasis for most human cancers. Recent research efforts in studying lymphangiogenesis have suggested the existence of a relationship between lymphatic vessel density and patient survival. However, current methodology of lymphangiogenesis quantification is still characterised by high intra- and interobserver variability. For the amount of lymphatic vessels in a tumour to be a clinically useful parameter, a reliable quantification technique needs to be developed. With this consensus report, we therefore would like to initiate discussion on the standardisation of the immunohistochemical method for lymphangiogenesis assessment.
Van der Auwera
I
I
Translational Cancer Research Group Antwerp, Laboratory of Pathology, University of Antwerp/University Hospital Antwerp, Edegem 2650, Belgium.
Cao
Y
Y
Tille
J C
JC
Pepper
M S
MS
Jackson
D G
DG
Fox
S B
SB
Harris
A L
AL
Dirix
L Y
LY
Vermeulen
P B
PB
D014408:Biomarkers, Tumor / Q000378:metabolism; D042783:Endothelial Cells / Q000473:pathology; D006801:Humans; D007124:Immunoenzyme Techniques / Q000379:methods*; D042583:Lymphangiogenesis; D008207:Lymphatic Metastasis; D042601:Lymphatic Vessels / Q000378:metabolism / Q000473:pathology*; D008562:Membrane Glycoproteins / Q000378:metabolism; D009369:Neoplasms / Q000098:blood supply / Q000473:pathology*; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism; D000098853:Podoplanin
D014408:Biomarkers, Tumor; D008562:Membrane Glycoproteins; D042461:Vascular Endothelial Growth Factor A; C117468:PDPN protein, human; D000098853:Podoplanin; C467484:VEGFA protein, human