title: Methods of analysis and separation of chiral flavonoids.
abstract: Although the analysis of the enantiomers and epimers of chiral flavanones has been carried out for over 20 years, there often remains a deficit within the pharmaceutical, agricultural, and medical sciences to address this issue. Hence, despite increased interest in the potential therapeutic uses, plant physiology roles, and health-benefits of chiral flavanones, the importance of stereoselectivity in agricultural, nutrition, pharmacokinetic, pharmacodynamic, pharmacological activity and disposition has often been ignored. This review presents both the general principles that allow separation of chiral flavanones, and discusses both the advantages and disadvantages of the available chromatographic assay methods and procedures used to separately quantify flavanone enantiomers and epimers in biological matrices.
authors.affiliation: College of Pharmacy, Department of Pharmaceutical Sciences and Pharmacology and Toxicology Graduate Program, Washington State University, Pullman, Washington 99164-6534, USA.
authors.forename: Jaime A
authors.initials: JA
authors.lastname: Yáñez
authors.forename: Preston K
authors.initials: PK
authors.lastname: Andrews
authors.forename: Neal M
authors.initials: NM
authors.lastname: Davies
mesh_terms: D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D044950:Flavanones / Q000737:chemistry / Q000302:isolation & purification*; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification*; D015203:Reproducibility of Results; D013237:Stereoisomerism
chemical_list: D044950:Flavanones; D005419:Flavonoids; C028610:flavanone