title: Usefulness of MRI volumetric evaluation in patients with squamous cell cancer of the head and neck treated with neoadjuvant chemotherapy.
abstract: BACKGROUND
  The purpose was to evaluate the efficacy of tumor volumetry on MRI as predictive of response to treatment with induction chemotherapy, comparing the results with endoscopy.
  
  
  METHODS
  Fifty patients with advanced squamous cell carcinoma of the head and neck (SSCHN) who underwent MRI volumetry before and after neoadjuvant chemotherapy consisting of docetaxel, cisplatin, and 5-fluorouracil (TPF) were included in this study. The tumor volume was calculated by a slice-by-slice evaluation. With the standard software of a workstation, the area of the tumor was measured slice by slice using manual segmentation. To evaluate the efficacy of MRI volumetry, pretreatment volume was compared with pretreatment remission status as evaluated with endoscopy.
  
  
  RESULTS
  Forty-five (90%) patients demonstrated a tumor downstaging after chemotherapy. Fourteen (28%) patients showed a complete histologic remission (CR), 31 (62%) patients showed a partial remission (PR). Pretreatment tumor volume was significantly different between patients whose tumor completely responded (CR) and those whose tumor did not completely respond or whose disease was stable or was progressive (p = .00023). We defined a threshold for the pretreatment tumor volume in patients with CR, which was equal to 29.71 cc.
  
  
  CONCLUSIONS
  We propose that MRI tumor volume analyses can be a useful parameter to predict the response to neoadjuvant chemotherapy in SCCHN.
authors.affiliation: Department for ENT-Surgery, University of Frankfurt/Main, Theodor-Stern-Kai, 60590 Frankfurt am Main, Germany.
authors.forename: Mehran
authors.initials: M
authors.lastname: Baghi
authors.forename: Martin G
authors.initials: MG
authors.lastname: Mack
authors.forename: Markus
authors.initials: M
authors.lastname: Hambek
authors.forename: Sotirios
authors.initials: S
authors.lastname: Bisdas
authors.forename: Ramona
authors.initials: R
authors.lastname: Muerthel
authors.forename: Jens
authors.initials: J
authors.lastname: Wagenblast
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Gstoettner
authors.forename: Thomas
authors.initials: T
authors.lastname: Vogl
authors.forename: Rainald
authors.initials: R
authors.lastname: Knecht
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000473:pathology*; D002945:Cisplatin / Q000008:administration & dosage; D000077143:Docetaxel; D004724:Endoscopy; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006258:Head and Neck Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D018365:Neoplasm, Residual; D011379:Prognosis; D012074:Remission Induction; D043823:Taxoids / Q000008:administration & dosage
chemical_list: D043823:Taxoids; D000077143:Docetaxel; D002945:Cisplatin; D005472:Fluorouracil