title: A comparison of primary two- and three-dimensional methods to review CT colonography.
abstract: The aim of our study was to compare primary three-dimensional (3D) and primary two-dimensional (2D) review methods for CT colonography with regard to polyp detection and perceptive errors. CT colonography studies of 77 patients were read twice by three reviewers, first with a primary 3D method and then with a primary 2D method. Mean numbers of true and false positives, patient sensitivity and specificity and perceptive errors were calculated with colonoscopy as a reference standard. A perceptive error was made if a polyp was not detected by all reviewers. Mean sensitivity for large (> or = 10 mm) polyps for primary 3D and 2D review was 81% (14.7/18) and 70%(12.7/18), respectively (p-values > or = 0.25). Mean numbers of large false positives for primary 3D and 2D were 8.3 and 5.3, respectively. With primary 3D and 2D review 1 and 6 perceptive errors, respectively, were made in 18 large polyps (p = 0.06). For medium-sized (6-9 mm) polyps these values were for primary 3D and 2D, respectively: mean sensitivity: 67%(11.3/17) and 61%(10.3/17; p-values > or = 0.45), number of false positives: 33.3 and 15.6, and perceptive errors : 4 and 6 (p = 0.53). No significant differences were found in the detection of large and medium-sized polyps between primary 3D and 2D review.
authors.affiliation: Department of Radiology, Academic Medical Center of the University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands. r.e.vangelder@amc.uva.nl
authors.forename: Rogier E
authors.initials: RE
authors.lastname: van Gelder
authors.forename: Jasper
authors.initials: J
authors.lastname: Florie
authors.forename: C Yung
authors.initials: CY
authors.lastname: Nio
authors.forename: Sebastiaan
authors.initials: S
authors.lastname: Jensch
authors.forename: Steven W
authors.initials: SW
authors.lastname: de Jager
authors.forename: Frans M
authors.initials: FM
authors.lastname: Vos
authors.forename: Henk W
authors.initials: HW
authors.lastname: Venema
authors.forename: Joep F
authors.initials: JF
authors.lastname: Bartelsman
authors.forename: Johannes B
authors.initials: JB
authors.lastname: Reitsma
authors.forename: Patrick M M
authors.initials: PM
authors.lastname: Bossuyt
authors.forename: Johan S
authors.initials: JS
authors.lastname: Laméris
authors.forename: Jaap
authors.initials: J
authors.lastname: Stoker
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003111:Colonic Polyps / Q000000981:diagnostic imaging*; D023881:Colonography, Computed Tomographic; D005189:False Positive Reactions; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional; D008297:Male; D008875:Middle Aged; D015588:Observer Variation; D011857:Radiographic Image Interpretation, Computer-Assisted / Q000379:methods*; D012680:Sensitivity and Specificity; D013997:Time Factors; D014584:User-Computer Interface