title: Efficacy of oxfendazole and fenbendazole against tortoise (Testudo hermanni) oxyurids.
abstract: Thirty-six tortoises (Testudo hermanni) with naturally acquired oxyurids infections were used to assess the anthelmintic efficacy of oxfendazole (Dolthene; Merial) and fenbendazole (Panacur; Hoechst Roussel Vet). Animals were randomly assigned to three groups (A, B, and C) based on sex and weight. Animals in group A (seven males and six females) were orally treated with oxfendazole at dose rate of 66 mg/kg, group B animals (nine males and eight females) were orally treated with fenbendazole at dose rate of 100 mg/kg, and group C animals (three males and three females) were not treated and served as controls. All animals were individually stabled in plexiglas boxes under controlled conditions of temperature, humidity, and light beginning 7 days pretreatment and continuing for the duration of the trial. Individual tortoises feces were examined daily by the McMaster technique and drugs efficacy was assessed by the fecal eggs count reduction (FECR) test. Both drugs showed 100% of FECR. However, oxfendazole reached this level 12 days after treatment, whereas 31 days after treatment were necessary to obtain the same stable result with fenbendazole. The two drugs were well tolerated by all the animals and no adverse reactions were observed after treatment.
authors.affiliation: Dipartimento di Sanità Pubblica Veterinaria, Facoltà di Medicina Veterinaria, Università degli Studi di Messina, Polo Universitario della Annunziata, 98168 Messina, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Giannetto
authors.forename: E
authors.initials: E
authors.lastname: Brianti
authors.forename: G
authors.initials: G
authors.lastname: Poglayen
authors.forename: C
authors.initials: C
authors.lastname: Sorgi
authors.forename: G
authors.initials: G
authors.lastname: Capelli
authors.forename: M G
authors.initials: MG
authors.lastname: Pennisi
authors.forename: G
authors.initials: G
authors.lastname: Coci
mesh_terms: D000818:Animals; D000969:Antinematodal Agents / Q000627:therapeutic use*; D001562:Benzimidazoles / Q000009:adverse effects / Q000627:therapeutic use*; D005243:Feces / Q000469:parasitology; D005260:Female; D005273:Fenbendazole / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D017167:Oxyurida / Q000187:drug effects*; D017194:Oxyurida Infections / Q000188:drug therapy / Q000662:veterinary*; D010270:Parasite Egg Count; D014426:Turtles / Q000469:parasitology*
chemical_list: D000969:Antinematodal Agents; D001562:Benzimidazoles; D005273:Fenbendazole; C011030:oxfendazole