title: Effect of ghrelin administration on phagocytic activity in acute cold-restraint stress exposed rats.
abstract: Ghrelin, an endogenous ligand for growth hormone secretagogue receptor, was identified in the rat stomach. This peptide acts through nitric oxide (NO) by expressing endothelial nitric oxide synthase (eNOS) and down regulating inducible nitric oxide synthase (iNOS) at its gastroproprotective effect against restraint stress induced damage. Recently the ghrelin receptor has also been detected in peripheral systems including immune tissue. We have investigated the possible effect of ghrelin on phagocytic activity of peritoneal macrophages in acute cold-restraint stress (ACRS) exposed rats. The rats were divided into control, stress and ghrelin groups. In ghrelin groups, single dose and three days consecutive dose of ghrelin (20 microg/kg. i.p.) were applied to rats that were exposed to ACRS for 4 h. 1 ml of saline was injected i.p. after ACRS for 3 consecutive days to the rats of the stress groups. Ghrelin administration reduced the increased phagocytic activity induced by ACRS. We conclude that ghrelin exerts an important role at macrophage phagocytic activity in ACRS exposed rats.
authors.affiliation: Dicle University Faculty of Medicine, Department of Physiology, 21280 Diyarbakir, Turkey. ctumer@dicle.edu.tr
authors.forename: Cemil
authors.initials: C
authors.lastname: Tümer
authors.forename: Hakki Murat
authors.initials: HM
authors.lastname: Bilgin
authors.forename: Basra Deniz
authors.initials: BD
authors.lastname: Obay
authors.forename: Hüda
authors.initials: H
authors.lastname: Diken
authors.forename: Ezel
authors.initials: E
authors.lastname: Taşdemir
authors.forename: Abdurrahman
authors.initials: A
authors.lastname: Sermet
mesh_terms: D000818:Animals; D003080:Cold Temperature; D054439:Ghrelin; D007274:Injections, Intraperitoneal; D017737:Macrophages, Peritoneal / Q000187:drug effects / Q000502:physiology; D008297:Male; D009573:Nitrites / Q000097:blood; D036361:Peptide Hormones / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D010587:Phagocytosis / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D012149:Restraint, Physical
chemical_list: D054439:Ghrelin; D009573:Nitrites; D036361:Peptide Hormones