Multiple hamartoma syndrome (Cowden's syndrome): case report and literature review.
Multiple hamartoma syndrome (also known as Cowden's syndrome) is a genetic disorder. The signs and symptoms of this disorder often do not appear concurrently or with the same degree of severity. While much of the literature regarding Cowden's syndrome (CS) focuses on the dermatologic and gastro-enterologic features of the disease, there also are unique oral and facial symptoms that manifest early in this condition. This disorder might be overlooked and underdiagnosed by the dental community. There is a strong link between CS and female breast cancer, thyroid cancer, gastrological polyps, and rare forms of brain cancer; as a result, it is essential for the dental community to gain a greater understanding of this syndrome and its unique oral manifestations.
Wright
Douglas D
DD
Veterans Administration Medical Center, Washington, DC, USA.
Whitney
James
J
D003937:Diagnosis, Differential; D005260:Female; D005882:Gingival Diseases / Q000209:etiology* / Q000473:pathology; D006223:Hamartoma Syndrome, Multiple / Q000150:complications*; D006801:Humans; D008875:Middle Aged; D009061:Mouth Mucosa / Q000473:pathology