title: Halichondria sulfonic acid, a new HIV-1 inhibitory guanidino-sulfonic acid, and halistanol sulfate isolated from the marine sponge Halichondria rugosa Ridley & Dendy.
abstract: A new sulfur-containing guanidino derivative, halichondria sulfonic acid (1) showing anti-HIV-1 activity, and halistanol trisulfate (2) with anti-tumor activity have been isolated from the marine sponge Halichondria rugosa Ridley & Dendy collected in the Chinese Southern Sea. The structure of 1 was elucidated by analysis of spectroscopic and crystal data.
authors.affiliation: Marine Bio-products Engineering Group, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Jin
authors.forename: S
authors.initials: S
authors.lastname: Fotso
authors.forename: Z
authors.initials: Z
authors.lastname: Yongtang
authors.forename: M
authors.initials: M
authors.lastname: Sevvana
authors.forename: H
authors.initials: H
authors.lastname: Laatsch
authors.forename: W
authors.initials: W
authors.lastname: Zhang
mesh_terms: D000818:Animals; D019380:Anti-HIV Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D002681:China; D018360:Crystallography, X-Ray; D004797:Enzyme-Linked Immunosorbent Assay; D006146:Guanidines / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D015497:HIV-1 / Q000187:drug effects*; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D009792:Oceans and Seas; D011161:Porifera / Q000737:chemistry*; D013055:Spectrophotometry, Infrared; D013057:Spectrum Analysis; D013261:Sterols / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D013451:Sulfonic Acids / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D013778:Tetrazolium Salts; D013844:Thiazoles
chemical_list: D019380:Anti-HIV Agents; D006146:Guanidines; C518347:Halichondria sulfonic acid; D013261:Sterols; D013451:Sulfonic Acids; D013778:Tetrazolium Salts; D013844:Thiazoles; C072244:halistanol trisulfate; C022616:thiazolyl blue