Serum levels of vitamin D and haemostatic factors in healthy subjects: the Tromsø study.
BACKGROUND
Receptors for vitamin D have been found in various tissues, including the vascular endothelium. The role of vitamin D in the haemostatic process is uncertain, but in vitro studies may indicate a pro-fibrinolytic effect.


METHODS
Two hundred and six subjects (105 males) were included in the study. The relations between indices of calcium metabolism and haemostatic factors [tissue plasminogen activator antigen (tPA Ag), plasminogen activator inhibitor 1 (PAI-1), prothrombin fragment 1+2, activated factor VII and total factor VII coagulant activity] and high-sensitivity C-reactive protein (HS-CRP) were examined.


RESULTS
There were significant and negative correlations between serum 25(OH) vitamin D and PAI-1 and tPA Ag, and between serum 1,25(OH)2 vitamin D and tPA Ag and HS-CRP. In a multiple linear regression model with age, gender, body mass index and smoking status as covariables, only the relation between 25(OH) vitamin D and tPA Ag was significant. There were no significant relations between any of the haemostatic factors tested and serum parathyroid hormone.


CONCLUSIONS
It appears that the serum level of vitamin D is related to fibrinolytic activity and to the integrity of the vascular endothelium, but the clinical importance of this observation remains to be determined.
Jorde
Rolf
R
Institute of Clinical Medicine, University of Tromsø, Tromsø, Norway. rolf.jorde@unn.no
Haug
Egil
E
Figenschau
Yngve
Y
Hansen
John-Bjarne
JB
D000328:Adult; D000368:Aged; D000941:Antigens / Q000097:blood*; D002117:Calcitriol / Q000097:blood; D005167:Factor VII; D015942:Factor VIIa / Q000032:analysis*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009664:Norway; D010446:Peptide Fragments / Q000097:blood*; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood*; D011516:Prothrombin; D012016:Reference Values; D010959:Tissue Plasminogen Activator / Q000097:blood*; D014807:Vitamin D / Q000097:blood*
D000941:Antigens; D010446:Peptide Fragments; D017395:Plasminogen Activator Inhibitor 1; C042580:factor VII clotting antigen; C045879:prothrombin fragment 1.2; D014807:Vitamin D; D005167:Factor VII; D011516:Prothrombin; D015942:Factor VIIa; D010959:Tissue Plasminogen Activator; D002117:Calcitriol