Malignant transformation of high-grade astrocytoma associated with neurocysticercosis in a patient with Turcot syndrome.
A 45-year-old woman with anaplastic astrocytoma was clinically diagnosed with Turcot syndrome, and subsequently developed simultaneous neurocysticercosis and malignant transformation to glioblastoma. The parasitic cysts and glioblastoma were microsurgically removed. Histological examination of surgical specimens revealed neurocysticercosis between the normal brain tissue and glioblastoma. The clinical course and histological findings suggest that the parasitic infection and/or genetic changes contributed to the malignant transformation of the astrocytic tumour.
Niizuma
Kuniyasu
K
Department of Neurosurgery, Tohoku University Graduate School of Medicine, 1-1, Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan.
Fujimura
Miki
M
Kumabe
Toshihiro
T
Tominaga
Tominaga
T
D001254:Astrocytoma / Q000150:complications / Q000473:pathology* / Q000601:surgery; D001932:Brain Neoplasms / Q000150:complications / Q000473:pathology* / Q000601:surgery; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D017809:Fatal Outcome; D005260:Female; D005909:Glioblastoma / Q000150:complications / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D020019:Neurocysticercosis / Q000469:parasitology / Q000473:pathology* / Q000601:surgery; D019635:Neurosurgical Procedures