Synchrotron SAX and WAX diffraction study of a hydrated very long-chain, dendritic amphiphile + DPPC mixture.
The tri-headed anionic dendritic amphiphile, 4-(2-carboxyethyl)-4-[(icosyloxycarbonyl)amino]heptanedioic acid (3CCb20), forms mixed aggregates with dipalmitoylphosphatidylcholine (DPPC) in excess water at 3CCb20:DPPC = 0.91:1 molar ratio. On heating, these mixed aggregates transform into fluid bilayers stacked in the liquid crystalline lamellar L(alpha) phase at about 40 degrees C. This phase transition and the microstructure of 3CCb20 + DPPC aggregates were studied with small- and wide-angle synchrotron X-ray diffraction. The ability of 3CCb20 to solubilize solidlike lipid bilayers could contribute to the antimicrobial activities of 3CCb20, including its anti-HIV activity.
Karlovská
Janka
J
Department of Physical Chemistry of Drugs, Comenius University, Odbojárov 10, 832 32 Bratislava, Slovakia.
Williams
André A
AA
Macri
Richard V
RV
Gandour
Richard D
RD
Funari
Sérgio S
SS
Uhríková
Daniela
D
Balgavý
Pavol
P
D015060:1,2-Dipalmitoylphosphatidylcholine / Q000737:chemistry*; D008051:Lipid Bilayers / Q000737:chemistry; D053838:Scattering, Small Angle; D013501:Surface-Active Agents / Q000737:chemistry*; D014961:X-Ray Diffraction
D008051:Lipid Bilayers; D013501:Surface-Active Agents; D015060:1,2-Dipalmitoylphosphatidylcholine