Reduction of optic nerve fibers in patients with Alzheimer disease identified by laser imaging.
In this case-control study, we compared the optic nerves (ONs) by clinical examination and scanning laser ophthalmoscopy (SLO) of 40 patients with Alzheimer disease (AD) and 50 controls. There was a reduction in the number of ON fibers in patients with AD, with a threefold greater odds ratio for a larger optic cup-to-disc ratio in patients with AD.
Danesh-Meyer
H V
HV
Department of Ophthalmology, University of Auckland, Auckland. New Zealand. h.daneshmeyer@auckland.ac.nz
Birch
H
H
Ku
J Y-F
JY
Carroll
S
S
Gamble
G
G
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000150:complications* / Q000175:diagnosis* / Q000503:physiopathology; D016022:Case-Control Studies; D002452:Cell Count; D005260:Female; D006801:Humans; D008297:Male; D018613:Microscopy, Confocal / Q000379:methods* / Q000639:trends; D019721:Ophthalmoscopes; D009900:Optic Nerve / Q000473:pathology* / Q000503:physiopathology; D009901:Optic Nerve Diseases / Q000175:diagnosis* / Q000209:etiology* / Q000503:physiopathology; D011237:Predictive Value of Tests; D012165:Retinal Ganglion Cells / Q000473:pathology; D014855:Wallerian Degeneration / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology