title: Long-term feeding a high-fat diet causes histological and parasitological effects on murine schistosomiasis mansoni outcome.
abstract: This study investigated whether long-term feeding a high-fat diet (HFC) has an effect on schistosomiasis mansoni outcome compared to standard chow diet (SC). Swiss Webster female mice (3 wk old) fed each diet over 5 months, and then were infected with 50 Schistosoma mansoni cercariae. Their nutritional status was assessed by monitoring growth rates twice a week and measuring serum levels of lipoproteins. Mice were euthanised 63 days after infection. Parasitological and liver histological analyses were performed. The levels of TC, HDL-C and LDL-C, fecal and tissue schistosome eggs were statistically different (p<0.05) between groups. Livers from HFC mice showed exudative, exudative/exudative-productive, exudative-productive and productive granulomas, some degree of hepatic steatosis and focal necrosis. Mice fed normal-chow did not present productive granulomas and hepatic steatosis. The morphometric evaluation of hepatic granulomas did not reach statistical significance (p>0.05) between diets assayed. The high-fat diet for long-term produces effects on schistosomiasis mansoni outcome.
authors.affiliation: Laboratory of Helminthology Romero Lascasas Porto, Biomedical Center, Department of Pathology and Laboratories, Faculty of Medical Sciences, State University of Rio de Janeiro, Brazil.
authors.forename: Renata Heisler
authors.initials: RH
authors.lastname: Neves
authors.forename: Alba Cristina
authors.initials: AC
authors.lastname: Miranda de Barros Alencar
authors.forename: Michele
authors.initials: M
authors.lastname: Costa-Silva
authors.forename: Márcia Barbosa
authors.initials: MB
authors.lastname: Aguila
authors.forename: Carlos Alberto
authors.initials: CA
authors.lastname: Mandarim-de-Lacerda
authors.forename: José Roberto
authors.initials: JR
authors.lastname: Machado-Silva
authors.forename: Delir Corrêa
authors.initials: DC
authors.lastname: Gomes
mesh_terms: D000818:Animals; D002784:Cholesterol / Q000097:blood; D004041:Dietary Fats / Q000008:administration & dosage / Q000009:adverse effects*; D004195:Disease Models, Animal; D005243:Feces / Q000469:parasitology; D005260:Female; D006099:Granuloma / Q000209:etiology / Q000473:pathology; D008099:Liver / Q000469:parasitology / Q000473:pathology; D051379:Mice; D009765:Obesity / Q000150:complications*; D010270:Parasite Egg Count; D012550:Schistosoma mansoni / Q000254:growth & development; D012555:Schistosomiasis mansoni / Q000209:etiology* / Q000473:pathology
chemical_list: D004041:Dietary Fats; D002784:Cholesterol