[MUC1 (EMA): A key molecule of carcinogenesis?].
MUC1 is a large trans-membrane highly glycosylated mucin which is expressed at the apical pole of normal cells in glandular epithelia. MUC1 is implicated in many physiological mechanisms such as adhesion, development and differentiation. Also, MUC1 is frequently deregulated and over-expressed with a membrane circumferential and/or cytoplasmic expression. The intracellular tail of MUC1 is phosphorylated and can interact with many signalling proteins and transcriptional factors. Indeed, MUC1 can interact with B-catenin competitively for E-cadherin, thus destabilizing intercellular junctions and favouring metastatic dissemination. In carcinomas, the overexpression and membrane delocalization of MUC1 is associated with a worse prognosis and a shorter survival in breast, colon, kidney, prostate or gastro-intestinal cancers. MUC1 appears to be a novel therapeutic target for immunotherapy or anti-tumour vaccines.
Leroy
Xavier
X
Service d'Anatomie Pathologique, Pôle Eurasanté, Bâtiment Biologie-Pathologie, CHRU, 59037 Lille. x-leroy@chru-lille.fr
Buisine
Marie-Pierre
MP
Leteurtre
Emmanuelle
E
Aubert
Sebastien
S
Buob
David
D
Porchet
Nicole
N
Copin
Marie-Christine
MC
D000951:Antigens, Neoplasm / Q000032:analysis / Q000235:genetics / Q000502:physiology*; D014408:Biomarkers, Tumor / Q000032:analysis; D002448:Cell Adhesion; D002454:Cell Differentiation; D005260:Female; D005786:Gene Expression Regulation; D005833:Genital Neoplasms, Female / Q000473:pathology; D006031:Glycosylation; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology; D008297:Male; D018396:Mucin-1; D009077:Mucins / Q000032:analysis / Q000235:genetics / Q000502:physiology*; D009369:Neoplasms / Q000473:pathology*; D009375:Neoplasms, Glandular and Epithelial / Q000473:pathology*; D011379:Prognosis; D014571:Urologic Neoplasms / Q000473:pathology
D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; C060192:MUC1 protein, human; D018396:Mucin-1; D009077:Mucins