Malnutrition-inflammation syndrome in a hemodialysis population: the influence of polymorphic IL-6-174 and IL-10-1082 genes.
OBJECTIVE
To find out inflammation prevalence in hemodialysis patients and whether polymorphic gene IL-6-174 and IL-10-1082 had prominent factors in malnutrition inflammation syndrome.


METHODS
A study on 81 patients who were on hemodialysis twice a week, 5 hours each session has been conducted. The subjects had no other co-morbidities and all of them used reprocessed diacetate cellulose dialyzers.


RESULTS
It was obtained that CRP blood level (6.23+/- 5.57 mg/L), inflammation prevalence (23.5%), and malnutrition inflammation score (6.7) were lower compared with the data from Europe and the United States. Out of 64 patients examined, IL-6-174GG 95.31%, CC 3.13% and GC 1.56%, IL-1082AA 89.06%, GA 10.94%, but absence of GG genotype. Considering the scanty amount of allele C in IL-6-174 gene and G allele in IL-10-1082 gene, based on the statistic analysis performed, it did not reveal the influence of the difference in allele on the clinical manifestation. The proportion of these alleles were almost similar to that obtained in Korea, Japan and China, but it was different from that obtained in the US and in Europe. A very resolute impression was obtained in HD patients in Jakarta that IL-6-174GG gene was protective in nature whereas IL-10-1082 AA gene had a less considerable role.


CONCLUSIONS
The prevalence of inflammation and malnutrition-inflammation parameters (CRP, malnutrition Inflammation Score) in our HD patients were lower than that reported in Western countries. This might be related to the low prevalence of IL-6-174C allele in our population.
Suhardjono
Division of Nephrology, Departement of Internal Medicine, Faculty of Medicine, University of Indonesia/Dr. Cipto Mangunkusumo Hospital, Jakarta.
D002097:C-Reactive Protein / Q000032:analysis; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D007214:Indonesia / Q000453:epidemiology; D007249:Inflammation / Q000453:epidemiology / Q000235:genetics* / Q000378:metabolism; D016753:Interleukin-10 / Q000032:analysis / Q000235:genetics; D015850:Interleukin-6 / Q000032:analysis / Q000235:genetics; D007676:Kidney Failure, Chronic / Q000453:epidemiology / Q000235:genetics* / Q000378:metabolism; D008297:Male; D044342:Malnutrition / Q000453:epidemiology / Q000235:genetics* / Q000378:metabolism; D008875:Middle Aged; D011110:Polymorphism, Genetic; D015995:Prevalence; D006435:Renal Dialysis
D015850:Interleukin-6; D016753:Interleukin-10; D002097:C-Reactive Protein