title: Oxidative cross-coupling through double transmetallation: surprisingly high selectivity for palladium-catalyzed cross-coupling of alkylzinc and alkynylstannanes.
abstract: Two different organometallic reagents now can cross-couple together with the oxidative cross-coupling strategy. Palladium catalyzed oxidative cross-couplings of alkylzinc and alkynylstannane reagents using desyl chloride as the oxidant have been explored, which produce the desired Csp-Csp3 cross-coupling product in surprisingly high selectivity and yields. The current catalytic system tolerates the presence of beta-H, and the reactions using long chain alkyl zinc reagents gave the cross-coupling product in excellent yields and selectivities.
authors.affiliation: College of Chemistry and Molecular Science, Wuhan University, Wuhan, 430072, P. R. China.
authors.forename: Yingsheng
authors.initials: Y
authors.lastname: Zhao
authors.forename: Haibo
authors.initials: H
authors.lastname: Wang
authors.forename: Xiaohui
authors.initials: X
authors.lastname: Hou
authors.forename: Yanhe
authors.initials: Y
authors.lastname: Hu
authors.forename: Aiwen
authors.initials: A
authors.lastname: Lei
authors.forename: Heng
authors.initials: H
authors.lastname: Zhang
authors.forename: Lizheng
authors.initials: L
authors.lastname: Zhu