title: MHC-linked susceptibility to type 1 diabetes in the NOD mouse: further localization of Idd16 by subcongenic analysis.
abstract: Although major histocompatibility complex (MHC)-linked susceptibility is the strongest component, recent studies demonstrated that MHC-linked susceptibility to type 1 diabetes consists of multiple components both in humans and non-obese diabetic (NOD) mouse. In the NOD mouse, Idd16 has been mapped to the region adjacent to, but distinct from Idd1 in the MHC class II region. Establishment of subcongenic NOD.CTS-H2 lines that possess the same MHC class II as the NOD mouse but non-NOD-derived chromosomal region in its adjacent regions, would facilitate further narrowing down of the localization of Idd16.
authors.affiliation: Department of Endocrinology, Diabetes and Metabolism, Kinki University School of Medicine, 377-2 Ohno-higashi, Sayama, Osaka 589-8511, Japan.
authors.forename: Tomomi
authors.initials: T
authors.lastname: Fujisawa
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ikegami
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Noso
authors.forename: Kaori
authors.initials: K
authors.lastname: Yamaji
authors.forename: Koji
authors.initials: K
authors.lastname: Nojima
authors.forename: Naru
authors.initials: N
authors.lastname: Babaya
authors.forename: Michiko
authors.initials: M
authors.lastname: Itoi-Babaya
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Hiromine
authors.forename: Misato
authors.initials: M
authors.lastname: Kobayashi
authors.forename: Susumu
authors.initials: S
authors.lastname: Makino
authors.forename: Toshio
authors.initials: T
authors.lastname: Ogihara
mesh_terms: D000818:Animals; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics* / Q000276:immunology*; D005500:Follow-Up Studies; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease; D008285:Major Histocompatibility Complex / Q000235:genetics*; D051379:Mice; D020297:Mice, Congenic; D016688:Mice, Inbred NOD; D020161:Physical Chromosome Mapping; D013997:Time Factors
chemical_list: D005819:Genetic Markers