title: Effect of substituents on diarylmethanes for antitubercular activity.
abstract: Aminoalkyl derivatives of diarylmethanes were prepared using Grignard, Friedel-Crafts arylation and aminohydrochloride chain formation reactions. These series of compounds were evaluated against Mycobacterium tuberculosis H(37)R(v) and showed the activity in the range of 6.25-25 microg/mL. Effect of heteroaryl, anthracenyl and phenanthrene groups on diarylmethane pharmacophores for antitubercular activity is described.
authors.affiliation: Medicinal and Process Chemistry Division, Central Drug Research Institute, Chattar Manzil Palace, Lucknow-226001, UP, India. gautam_panda@lycos.com
authors.forename: Gautam
authors.initials: G
authors.lastname: Panda
authors.forename: Maloy Kumar
authors.initials: MK
authors.lastname: Parai
authors.forename: Sajal Kumar
authors.initials: SK
authors.lastname: Das
authors.lastname: Shagufta
authors.forename: Manish
authors.initials: M
authors.lastname: Sinha
authors.forename: Vinita
authors.initials: V
authors.lastname: Chaturvedi
authors.forename: Anil K
authors.initials: AK
authors.lastname: Srivastava
authors.forename: Y S
authors.initials: YS
authors.lastname: Manju
authors.forename: Anil N
authors.initials: AN
authors.lastname: Gaikwad
authors.forename: Sudhir
authors.initials: S
authors.lastname: Sinha
mesh_terms: D000818:Animals; D000995:Antitubercular Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002522:Chlorocebus aethiops; D004354:Drug Screening Assays, Antitumor; D007202:Indicators and Reagents; D008264:Macrophages / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008697:Methane / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology*; D051379:Mice; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D013055:Spectrophotometry, Infrared; D013329:Structure-Activity Relationship; D014709:Vero Cells
chemical_list: D000995:Antitubercular Agents; D007202:Indicators and Reagents; D008697:Methane