title: Effect of maximal exercise on the short-term kinetics of zinc metabolism in sedentary men.
abstract: OBJECTIVE
  To examine the effect of acute exhaustive exercise versus rest on short-term zinc kinetics in men.
  
  
  METHODS
  Crossover design, wherein all subjects were their own control.
  
  
  METHODS
  University setting, where subjects were free living.
  
  
  METHODS
  12 healthy, sedentary men, 25-35 years of age.
  
  
  METHODS
  (70)Zn was infused 10 min after exercise or at rest. Plasma zinc concentrations were measured at baseline and 2, 5, 10, 15, 30, 45, 60, 75, 90 and 120 min after exercise or rest. Haematocrit was measured before and after exercise to assess changes in plasma volume.
  
  
  METHODS
  Plasma zinc (primary), serum creatine kinase and serum cortisol concentrations (secondary).
  
  
  RESULTS
  Plasma zinc concentrations decreased (p<0.05) after exercise, with a mean (SD) nadir of 13.9% (4.1%) observed at 70 min after exercise. There were increases in the size of the rapidly exchangeable plasma zinc pool (Qa; from 3.1 (0.2) to 3.6 (0.2) mg; p<0.05) and the liver zinc pool (Qb; from 10.2 (0.6) to 11.4 (0.8) mg; p = 0.12).
  
  
  CONCLUSIONS
  Exercise seems to cause a shift of plasma zinc into the interstitial fluid and liver after exercise, which may reflect the acute stress response of strenuous exercise.
authors.affiliation: Division of Biobehavioral and Health Sciences, University of Pennsylvania, School of Nursing, Philadelphia, PA 19104-6096, USA. svolpe@nursing.upenn.edu
authors.forename: Stella Lucia
authors.initials: SL
authors.lastname: Volpe
authors.forename: Nicola M
authors.initials: NM
authors.lastname: Lowe
authors.forename: Leslie R
authors.initials: LR
authors.lastname: Woodhouse
authors.forename: Janet C
authors.initials: JC
authors.lastname: King
mesh_terms: D000328:Adult; D018592:Cross-Over Studies; D004032:Diet; D015444:Exercise / Q000502:physiology*; D006801:Humans; D007700:Kinetics; D008019:Life Style; D008297:Male; D005082:Physical Exertion / Q000502:physiology; D015032:Zinc / Q000378:metabolism*
chemical_list: D015032:Zinc