title: Antibacterial and anticoagulant activities of coumarins isolated from the flowers of Magydaris tomentosa.
abstract: The phytochemical investigation of the acetone and methanol extracts of the flowers of Magydaris tomentosa (Desf.) DC afforded six known coumarins as well as (+)-meranzin hydrate (7), not previously reported as a natural product. The antibacterial activity of umbelliprenin (1), osthol (2), imperatorin (3), citropten (4) and (+)-meranzin hydrate (7) was tested against Gram-positive and Gram-negative bacteria. All coumarins (1-7) isolated in this study inhibited growth of all bacterial strains tested (MIC between 16 and 256 microg/mL), the most active being imperatorin (3) (MICs between 32 and 128 microg/mL) and citropten (4) (MICs between 16 and 256 microg/mL). The anticoagulant activity of compounds 1-4 and 7 was also evaluated.
authors.affiliation: Dipartimento di Chimica Organica, Università degli Studi di Palermo, Palermo, Italy.
authors.forename: Sergio
authors.initials: S
authors.lastname: Rosselli
authors.forename: Antonella
authors.initials: A
authors.lastname: Maggio
authors.forename: Gabriella
authors.initials: G
authors.lastname: Bellone
authors.forename: Carmen
authors.initials: C
authors.lastname: Formisano
authors.forename: Adriana
authors.initials: A
authors.lastname: Basile
authors.forename: Carla
authors.initials: C
authors.lastname: Cicala
authors.forename: Alessio
authors.initials: A
authors.lastname: Alfieri
authors.forename: Nicola
authors.initials: N
authors.lastname: Mascolo
authors.forename: Maurizio
authors.initials: M
authors.lastname: Bruno
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000925:Anticoagulants / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D019661:Apiaceae / Q000737:chemistry*; D003374:Coumarins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D035264:Flowers / Q000737:chemistry; D008297:Male; D008826:Microbial Sensitivity Tests; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000900:Anti-Bacterial Agents; D000925:Anticoagulants; D003374:Coumarins