[Radioprotective effect of catechines against radiation injury in mice].
OBJECTIVE
To study the radioprotective effect of catechines against radiation injury in mice.


METHODS
Catechines were administered in mice intragastrically at the daily dose of 200 mg/kg for 10 consecutive days before whole body irradiation with 6 Gy X-rays. The body weight changes, survival time, 30-day survival rate, and counts of peripheral white blood cells were recorded.


RESULTS
The mice with catechine pre-treatment before X-ray exposure suffered less body weight loss than those without the treatment before exposure. Catechines markedly increased the survival time of the irradiated mice, and raised the 30-d survival rate of the irradiated mice to 53.33% as compared with the rate of 13.33% in the radiated mice without catechine pre-treatment. Catechines significantly promoted recovery of peripheral white blood cells.


CONCLUSIONS
Catechines have definite radioprotective effect against radiation injury in mice.
Shi
Wei-min
WM
Department of Oncology, Guangzhou General Hospital of Guangzhou Command, Guangzhou 510010, China.
Zhao
Xin-ping
XP
Lu
Ting
T
D000818:Animals; D002392:Catechin / Q000494:pharmacology*; D005260:Female; D007958:Leukocyte Count; D051379:Mice; D011833:Radiation Injuries, Experimental / Q000097:blood / Q000401:mortality / Q000517:prevention & control*; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D011897:Random Allocation; D016019:Survival Analysis; D015996:Survival Rate; D013997:Time Factors; D014916:Whole-Body Irradiation / Q000009:adverse effects
D011837:Radiation-Protective Agents; D002392:Catechin