title: Dynamics of single-cell gene expression.
abstract: Cellular behavior has traditionally been investigated by utilizing bulk-scale methods that measure average values for a population of cells. Such population-wide studies mask the behavior of individual cells and are often insufficient for characterizing biological processes in which cellular heterogeneity plays a key role. A unifying theme of many recent studies has been a focus on the development and utilization of single-cell experimental techniques that are capable of probing key biological phenomena in individual living cells. Recently, novel information about gene expression dynamics has been obtained from single-cell experiments that draw upon the unique capabilities of fluorescent reporter proteins.
authors.affiliation: Department of Bioengineering, University of California at San Diego, La Jolla, CA 92093-0412, USA. hasty@ucsd.edu
authors.forename: Diane
authors.initials: D
authors.lastname: Longo
authors.forename: Jeff
authors.initials: J
authors.lastname: Hasty
mesh_terms: D000818:Animals; D001412:Bacillus subtilis / Q000166:cytology*; D002477:Cells / Q000378:metabolism*; D004926:Escherichia coli / Q000166:cytology*; D005786:Gene Expression Regulation; D044085:Microfluidics