Brain MR spectroscopy findings in neonates with hypothyroidism born to mothers living in iodine-deficient areas.
OBJECTIVE
Iodine deficiency and hypothyroxinemia have a negative effect on the development of the central nervous system during fetal and early postnatal life. MR spectroscopy is a sensitive technique for detecting the changes of brain metabolites in various neurodevelopmental disorders. By using MR spectroscopy, we aimed to show the decrease in N-acetylaspartate (NAA) levels in neonates with hypothyroidism who were born in iodine-deficient areas and its normalization with early thyroxine therapy.


METHODS
Eight congenital hypothyroid and 8 healthy full-term neonates were chosen as study and control groups, respectively. Serum thyroid hormones and median urinary iodine concentration of the neonates and their mothers were measured. Measurements of NAA, choline (Cho), and creatine (Cr) were made in frontal white matter, parietal white matter (PWM), and the thalamus with MR spectroscopy, first at 5-7 days of life and after 8 weeks of thyroxine therapy in the study group and at the same time in the control group.


RESULTS
The patient group had significantly lower NAA/Cr ratios in PWM and the thalamus (P < .05, for each), whereas the difference between Cho/Cr ratios of the 2 groups before therapy was not significant. After 8 weeks of thyroxine therapy, measurements did not show significant difference between study and control groups.


CONCLUSIONS
MR spectroscopy performed in neonates with hypothyroidism reveals that intrauterine hypothyroxinemia due to iodine deficiency results in significant decrease in NAA levels in PWM and the thalamus and that the normalization of NAA levels is achieved with early thyroxine therapy.
Akinci
A
A
Department of Pediatric Endocrinology, Inönü University, Turgut Ozal Medical Center, Malatya, Turkey. aakinci@inonu.edu.tr
Sarac
K
K
Güngör
S
S
Mungan
I
I
Aydin
O
O
D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000378:metabolism; D001921:Brain / Q000378:metabolism*; D016022:Case-Control Studies; D004781:Environmental Exposure; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000378:metabolism*; D007231:Infant, Newborn; D007455:Iodine / Q000172:deficiency*; D009682:Magnetic Resonance Spectroscopy; D009035:Mothers; D011247:Pregnancy
D001224:Aspartic Acid; D007455:Iodine; C000179:N-acetylaspartate