RamB, the transcriptional regulator of acetate metabolism in Corynebacterium glutamicum, is subject to regulation by RamA and RamB.
In Corynebacterium glutamicum, the transcriptional regulator RamB negatively controls the expression of genes involved in acetate metabolism. Here we show that RamB represses its own expression by direct interaction with a 13-bp motif in the ramB promoter region. Additionally, ramB expression is subject to carbon source-dependent positive control by RamA.
Cramer
Annette
A
Department of Microbiology and Biotechnology, University of Ulm, 89069 Ulm, Germany.
Auchter
Marc
M
Frunzke
Julia
J
Bott
Michael
M
Eikmanns
Bernhard J
BJ
D000085:Acetates / Q000378:metabolism* / Q000494:pharmacology; D001426:Bacterial Proteins / Q000235:genetics* / Q000378:metabolism; D015153:Blotting, Western; D048230:Corynebacterium glutamicum / Q000187:drug effects / Q000235:genetics* / Q000378:metabolism; D024202:Electrophoretic Mobility Shift Assay; D015964:Gene Expression Regulation, Bacterial; D005947:Glucose / Q000494:pharmacology; D008954:Models, Biological; D011401:Promoter Regions, Genetic; D011485:Protein Binding; D014158:Transcription, Genetic
D000085:Acetates; D001426:Bacterial Proteins; D005947:Glucose