[The effect of the time of death on the reactivity of rat caudal artery regulated by Bay-K 8644 (an agonist directly affecting the Ca channel)].
The research was conducted on Bay-K 8644-perfused rat caudal arteries in four different time groups. Investigations using the direct Ca channel agonist demonstrated a time-dependent decrease of arterial reactivity. The authors determined that the contractions of the smooth muscle coat preceded by an increased cytoplasm Ca++ level were significantly prolonged by the activation of direct Ca++ inflow from the extracellular space.
Bloch-Bogusławska
Elzbieta
E
Katedry i Zakładu Medycyny Sadowej UMK w Toruniu CM w Bydgoszczy.
D001498:3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester / Q000494:pharmacology; D000818:Animals; D017209:Apoptosis / Q000187:drug effects / Q000502:physiology*; D001158:Arteries / Q000187:drug effects / Q000378:metabolism*; D002120:Calcium Channel Agonists / Q000494:pharmacology; D015220:Calcium Channels / Q000378:metabolism*; D007425:Intracellular Membranes / Q000378:metabolism; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D011180:Postmortem Changes; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D002120:Calcium Channel Agonists; D015220:Calcium Channels; D001498:3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester