Schizotypy, attention deficit hyperactivity disorder, and dopamine genes.
Previous research has suggested that there may be overlap between schizophrenia and attention-deficit hyperactivity disorder (ADHD). The relationship between schizotypal personality traits, ADHD features and polymorphisms was evaluated in dopamine-related genes. Thirty-one healthy, Caucasian men completed the Rust Inventory of Schizotypal Cognitions (RISC) and the ADHD Self-Report Scale (ASRS). Catechol-O-methyltransferase (COMT) Val158Met, dopamine receptors of the D3 type (DRD3) Ser9Gly, DRD4 variable number of tandem repeats (VNTR), and SLC6A3 VNTR polymorphisms were analyzed. RISC score was correlated with ASRS score (r = 0.54, P = 0.003). COMT Met homozygotes had higher ASRS scores than Val homozygotes (P = 0.005). These findings are consistent with evidence of overlap between schizophrenia and ADHD and support an involvement of COMT genotype in ADHD features.
Ettinger
Ulrich
U
Centre for Neuroimaging Sciences, Institute of Psychiatry, King's College London, London, UK. u.ettinger@iop.kcl.ac.uk
Joober
Ridha
R
DE Guzman
Rosherrie
R
O'driscoll
Gillian A
GA
D000328:Adult; D000483:Alleles; D001289:Attention Deficit Disorder with Hyperactivity / Q000235:genetics*; D002394:Catechol O-Methyltransferase / Q000235:genetics; D003071:Cognition / Q000502:physiology; D004247:DNA / Q000235:genetics; D004298:Dopamine / Q000235:genetics*; D050483:Dopamine Plasma Membrane Transport Proteins / Q000235:genetics; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic; D011569:Psychiatric Status Rating Scales; D050637:Receptors, Dopamine D3 / Q000235:genetics; D050638:Receptors, Dopamine D4 / Q000235:genetics; D012569:Schizotypal Personality Disorder / Q000235:genetics*; D011795:Surveys and Questionnaires
D050483:Dopamine Plasma Membrane Transport Proteins; D050637:Receptors, Dopamine D3; C493214:SLC6A3 protein, human; D050638:Receptors, Dopamine D4; D004247:DNA; D002394:Catechol O-Methyltransferase; D004298:Dopamine