title: Effect of immunoadsorption on refractory idiopathic focal and segmental glomerulosclerosis.
abstract: A case of a young adult with refractory nephrotic syndrome due to focal segmental glomerulosclerosis is reported. Several treatments had been used without success including steroids, cyclophosphamide, cyclosporine A, tacrolimus, and mycophenolate mofetil. Immunoadsorption was performed as a last resort to manage the nephrotic syndrome, which led to a drastic urinary protein reduction. We review the literature supporting immunoadsorption in primary focal segmental glomerulosclerosis.
authors.affiliation: Department of Internal Medicine II, University-Hospital Halle-Kröllwitz, Halle, Germany. christian.kuhn@medizin.uni-halle.de
authors.forename: Christian
authors.initials: C
authors.lastname: Kuhn
authors.forename: Andrea
authors.initials: A
authors.lastname: Kuhn
authors.forename: Silke
authors.initials: S
authors.lastname: Markau
authors.forename: Uta
authors.initials: U
authors.lastname: Kästner
authors.forename: Bernd
authors.initials: B
authors.lastname: Osten
mesh_terms: D000328:Adult; D000749:Anemia, Megaloblastic / Q000139:chemically induced; D047228:Angiotensin II Type 1 Receptor Blockers / Q000627:therapeutic use; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D001379:Azathioprine / Q000009:adverse effects / Q000627:therapeutic use; D001798:Blood Proteins / Q000737:chemistry; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000627:therapeutic use; D004351:Drug Resistance; D005923:Glomerulosclerosis, Focal Segmental / Q000150:complications / Q000628:therapy*; D006801:Humans; D007163:Immunosorbent Techniques; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000627:therapeutic use; D008297:Male; D009173:Mycophenolic Acid / Q000031:analogs & derivatives / Q000627:therapeutic use; D009404:Nephrotic Syndrome / Q000209:etiology; D010956:Plasmapheresis; D011507:Proteinuria / Q000209:etiology; D012685:Sepharose / Q000737:chemistry; D013205:Staphylococcal Protein A / Q000737:chemistry; D016559:Tacrolimus / Q000627:therapeutic use
chemical_list: D047228:Angiotensin II Type 1 Receptor Blockers; D000806:Angiotensin-Converting Enzyme Inhibitors; D001798:Blood Proteins; D007166:Immunosuppressive Agents; D013205:Staphylococcal Protein A; D003520:Cyclophosphamide; D012685:Sepharose; D009173:Mycophenolic Acid; D001379:Azathioprine; D016559:Tacrolimus