title: "Click to chelate": synthesis and installation of metal chelates into biomolecules in a single step.
abstract: Click chemistry has been employed for the assembly of novel and efficient triazole-based multidentate chelating systems while simultaneously attaching them to molecules of biological interest. The "click-to-chelate" approach offers a powerful new tool for the modification of (bio)molecules with metal chelators for potential diagnostic and therapeutic applications.
authors.affiliation: Department of Chemistry and Applied Biosciences, ETH Zurich, 8093 Zurich, Switzerland.
authors.forename: Thomas L
authors.initials: TL
authors.lastname: Mindt
authors.forename: Harriet
authors.initials: H
authors.lastname: Struthers
authors.forename: Luc
authors.initials: L
authors.lastname: Brans
authors.forename: Todor
authors.initials: T
authors.lastname: Anguelov
authors.forename: Christian
authors.initials: C
authors.lastname: Schweinsberg
authors.forename: Veronique
authors.initials: V
authors.lastname: Maes
authors.forename: Dirk
authors.initials: D
authors.lastname: Tourwé
authors.forename: Roger
authors.initials: R
authors.lastname: Schibli
mesh_terms: D000409:Alanine / Q000031:analogs & derivatives; D000480:Alkynes / Q000737:chemistry; D001386:Azides / Q000737:chemistry; D002614:Chelating Agents / Q000737:chemistry*; D007553:Isotope Labeling / Q000379:methods*; D008670:Metals / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry; D014230:Triazoles / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D000480:Alkynes; D001386:Azides; D002614:Chelating Agents; D008670:Metals; D010455:Peptides; D014230:Triazoles; D000409:Alanine