International Union of Pharmacology. LX. Retinoic acid receptors.
Retinoid is a term for compounds that bind to and activate retinoic acid receptors (RARalpha, RARbeta, and RARgamma), members of the nuclear hormone receptor superfamily. The most important endogenous retinoid is all-trans-retinoic acid. Retinoids regulate a wide variety of essential biological processes, such as vertebrate embryonic morphogenesis and organogenesis, cell growth arrest, differentiation and apoptosis, and homeostasis, as well as their disorders. This review summarizes the considerable amount of knowledge generated on these receptors.
Germain
Pierre
P
Centre National de la Recherche Scientifique/Institut National de la Santé et de la Recherche Médicale/Université Louis Pasteur, Illkirch, Communauté Urbaine de Strasbourg, France. germain@titus.u-strasbg.fr
Chambon
Pierre
P
Eichele
Gregor
G
Evans
Ronald M
RM
Lazar
Mitchell A
MA
Leid
Mark
M
De Lera
Angel R
AR
Lotan
Reuben
R
Mangelsdorf
David J
DJ
Gronemeyer
Hinrich
H
D000818:Animals; D001667:Binding, Competitive; D015870:Gene Expression; D006801:Humans; D009154:Mutation; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism / Q000517:prevention & control; D018168:Receptors, Retinoic Acid / Q000235:genetics / Q000378:metabolism*; D012176:Retinoids / Q000378:metabolism* / Q000627:therapeutic use; D012871:Skin Diseases / Q000235:genetics / Q000378:metabolism / Q000517:prevention & control; D014212:Tretinoin / Q000502:physiology / Q000627:therapeutic use
D018168:Receptors, Retinoic Acid; D012176:Retinoids; D014212:Tretinoin