title: Cerebral edema in a patient following cytoreductive surgery and hyperthermic intraoperative intraperitoneal chemoperfusion.
abstract: BACKGROUND
  Cytoreductive surgery and intraoperative, intraperitoneal hyperthermic chemoperfusion (HIPEC) is increasingly used to treat peritoneal surface metastases. We describe a fatal case of cerebral edema in a patient with appendiceal carcinoma and an underlying seizure disorder who underwent cytoreductive surgery and HIPEC.
  
  
  METHODS
  A case of fatal postoperative cerebral edema is presented in a patient with an underlying seizure disorder and recurrent mucinous adenocarcinoma of the appendix. The patient was treated with cytoreductive surgery and intraoperative intraperitoneal hyperthermic chemoperfusion. The details and implications of this complication are discussed.
  
  
  CONCLUSIONS
  The recognition of this potential complication is important for physicians performing cytoreductive surgery and HIPEC. Special caution should be taken when patients with seizure disorders are being considered for this treatment.
authors.affiliation: Department of Surgery, Division of Surgical Oncology, University of Cincinnati, Cincinnati, OH 45267, USA. nair_rl@yahoo.com
authors.forename: Rajalakshmi L
authors.initials: RL
authors.lastname: Nair
authors.forename: Jonathan
authors.initials: J
authors.lastname: Tobias
authors.forename: Grant
authors.initials: G
authors.lastname: Stemmerman
authors.forename: Andrew M
authors.initials: AM
authors.lastname: Lowy