title: Percutaneous coronary intervention increases leptin and decreases adiponectin levels.
abstract: OBJECTIVE
  The study was designed to examine the effect of percutaneous coronary intervention (PCI) on adiponectin and leptin levels. We have previously demonstrated that PCI triggers a systemic inflammatory response. We hypothesized that inflammation participates in the pathogenesis of diabetes mellitus and the metabolic syndrome by modulating levels of adiponectin and leptin.
  
  
  METHODS
  Prospective study in which inflammation was induced by PCI.
  
  
  METHODS
  Forty-eight patients with stable coronary artery disease and without diabetes mellitus.
  
  
  METHODS
  High-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), leptin and adiponectin were measured at baseline and 48 h after the procedure.
  
  
  RESULTS
  Following PCI, hs-CRP increased by 211%, IL-6 by 87% and leptin by 19%, while adiponectin decreased by 14% (P < 0.001 for all). The change in IL-6 correlated with that in hs-CRP (rho = 0.32; P = 0.027), as did the changes in IL-6 and leptin (rho = 0.31; P = 0.03). The change in adiponectin, however, did not correlate with the change in any of the other markers.
  
  
  CONCLUSIONS
  This study demonstrates that PCI affects the levels of adiponectin and leptin within 48 h. These effects may be secondary to the inflammatory response triggered by PCI.
authors.affiliation: Division of Cardiology, Hotel Dieu de France Hospital and the Saint-Joseph University School of medicine, Beirut, Lebanon. razar@usj.edu.lb
authors.forename: Rabih R
authors.initials: RR
authors.lastname: Azar
authors.forename: Antoine
authors.initials: A
authors.lastname: Sarkis
authors.forename: Elie
authors.initials: E
authors.lastname: Salameh
authors.forename: Marie-Hélène
authors.initials: MH
authors.lastname: Gannagé-Yared
authors.forename: Mireille
authors.initials: M
authors.lastname: Amm-Azar
authors.forename: Georges
authors.initials: G
authors.lastname: Badaoui
authors.forename: Mirna
authors.initials: M
authors.lastname: Germanos
authors.forename: Roland
authors.initials: R
authors.lastname: Kassab
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D003327:Coronary Disease / Q000097:blood* / Q000276:immunology / Q000628:therapy*; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D020738:Leptin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D011446:Prospective Studies; D018709:Statistics, Nonparametric
chemical_list: D052242:Adiponectin; D015415:Biomarkers; D015850:Interleukin-6; D020738:Leptin; D002097:C-Reactive Protein