title: Prehistory of the notion of circulating nucleic acids in plasma/serum (CNAPS): birth of a hypothesis.
abstract: In the late 50s and early 60s of the last century, a theoretical fight was taking place between Western and Russian scientists about the theory explaining the mechanism of evolution. According to neo-Darwinism, evolution was the result of hazard and necessity, that is, mutations arriving by chance favoring the survival of the fittest. For the Russian geneticists, acquired characteristics were the basis of evolution, that is, the environment modified the characteristics of the gene. One of the main experiments on which the Russian geneticists based their theory was the transmission of hereditary characteristics by a special technique of grafting between two varieties of plants-a mentor plant and a pupil plant. The pupil variety being entirely dependent on the development of the mentor plant its hereditary characteristics were modified accordingly. In the Western world these experiments were regarded with doubt. We were among the few who tried to repeat this kind of experiment. After three generations of grafting between two varieties of eggplant, we succeeded in obtaining hereditary modifications of the pupil plants, which acquired some of the characteristics of the mentor variety. The linkage between some hereditary characteristics of the mentor plant were broken, the segregation of the offspring was abnormal, dominant characteristics appearing in the offspring of a recessive plant. Rather than adopting the views of the Russian scientists about acquired characteristics, we suggested that DNA was circulating between the mentor and pupil plants and assumed that some nucleic acid molecules bearing genetic information could enter the somatic and reproductive cells of the pupil plant at a propitious moment and remain active.
authors.affiliation: OncoXL, 14 Chemin des Aulx, 1228 Plan les Ouates/Geneva, Switzerland. mauricestroun@bluewin.ch
authors.forename: Maurice
authors.initials: M
authors.lastname: Stroun
authors.forename: Philippe
authors.initials: P
authors.lastname: Anker
mesh_terms: D005075:Biological Evolution; D006801:Humans; D008962:Models, Theoretical; D009696:Nucleic Acids / Q000097:blood*; D010641:Phenotype; D012426:Russia; D032323:Solanum melongena / Q000033:anatomy & histology / Q000235:genetics*; D019737:Transplants; D014481:United States
chemical_list: D009696:Nucleic Acids