Alpha(2)-blocker helps to avoid systemic to pulmonary shunt in a prostaglandin dependent infant with critical pulmonary valve stenosis.
A 27 days old newborn with critical pulmonary valve stenosis remained prostaglandin (PGE(1)) dependent for 2 weeks after successful balloon valvuloplasty. Only the introduction of Phentolamine in his medication regimen, allowed PGE(1) to be weaned off within days of this therapy. The medication was continued for 4 days and replaced by angiotensin converting enzyme inhibitor (Captopril). Few weeks after the discharge, the patient remained clinically stable with acceptable saturation.
Galal
Mohammad Omar
MO
Department of Cardiovascular Diseases, Section of Pediatric Cardiology, King Faisal Specialist Hospital and RC, Jeddah, Saudi Arabia.
Arfi
Amin Muhammad
AM
Ata
Jameel Al
JA
Hussain
Arif
A
Kouatli
Amjad
A
D000317:Adrenergic alpha-Antagonists / Q000627:therapeutic use*; D000527:Alprostadil / Q000627:therapeutic use; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D010646:Phentolamine / Q000627:therapeutic use*; D011652:Pulmonary Circulation; D011666:Pulmonary Valve Stenosis / Q000151:congenital* / Q000188:drug therapy* / Q000503:physiopathology; D014665:Vasodilator Agents / Q000627:therapeutic use
D000317:Adrenergic alpha-Antagonists; D014665:Vasodilator Agents; D000527:Alprostadil; D010646:Phentolamine