title: Clinical manifestations of hemoglobin Chico at high altitude.
abstract: Hemoglobin Chico is a rare hemoglobinopathy characterized by low oxygen affinity and a right-shifted oxygen dissociation curve. Detailed clinical evaluations of affected individuals have not been previously reported. We therefore report on the clinical features of Hemoglobin Chico in a Latino male living at high altitude, who desired to participate in school sports. As a young boy with asthma, he had the unusual finding of growth delay and digital clubbing which improved with asthma control. At 16 years of age, he had mild anemia and a decreased pulse oximetry (83%) but sufficient pulmonary reserve to participate in physically demanding activities.
authors.affiliation: Department of Pathology, The University of New Mexico, Albuquerque, NM, USA.
authors.forename: Cindi R
authors.initials: CR
authors.lastname: Starkey
authors.forename: Lea
authors.initials: L
authors.lastname: Davies
authors.forename: James D
authors.initials: JD
authors.lastname: Hoyer
authors.forename: Carla S
authors.initials: CS
authors.lastname: Wilson
authors.forename: Stuart S
authors.initials: SS
authors.lastname: Winter
mesh_terms: D000293:Adolescent; D000531:Altitude; D000740:Anemia / Q000209:etiology; D001249:Asthma / Q000150:complications; D006453:Hemoglobinopathies / Q000175:diagnosis*; D006455:Hemoglobins, Abnormal; D006801:Humans; D008297:Male; D010092:Oximetry
chemical_list: D006455:Hemoglobins, Abnormal; C054742:hemoglobin Chico