Enantioselective reduction of ketones with borane catalyzed by tridentate amino alcohols derived from salicylaldehyde.
In the presence of tridentate chiral ligand 4e, 99% e.e. value was obtained by asymmetric reduction of ethyl benzoylacetate with borane in toluene at 25 degrees C. Various ligands and reaction conditions were investigated to develop a reasonable mechanism that explains the experimental outcomes.
Lee
Dong-Sheng
DS
Department of Chemistry, National Chung-Hsing University, Taichung, Taiwan, Republic of China. dslee@mail.nchu.edu.tw