title: Can measurement of the intima-media thickness of the carotid artery improve the diagnostic value of exercise stress tests?
abstract: OBJECTIVE
  The diagnostic value of the exercise electrocardiogram (ECG) for the detection of coronary artery disease is hampered by a high proportion of equivocal results, especially in asymptomatic patients. The intima-media thickness of the carotid artery correlates well with the degree of atherosclerosis, also in other vascular beds, such as the coronary arteries. The aim of this study is to evaluate whether measurements of intima-media thickness can improve the diagnostic value of stress ECG in the detection of coronary artery disease.
  
  
  METHODS
  Patients without a history of vascular disease and with equivocal exercise stress ECG results were included. The intima-media thickness was measured with high resolution echography at the posterior wall of the common carotid artery, using an automated edge-tracking method. The diagnosis of coronary artery disease was based on the presence of reversible perfusion defects on exercise MIBI-scintigrams.
  
  
  RESULTS
  A total of 90 patients (46 men, 44 women) with a mean age of 53.7 years were included. The MIBI-scintigraphy was positive in 17. There was no difference in mean intima-media thickness between MIBI positive and MIBI negative patients (635.76 +/- 84.56 microm and 643.89 +/- 107.06 microm, respectively, p = 0.8). Using multiple regression analysis, neither intima-media thickness measurements, nor classic risk factors could predict the result of MIBI-scintigraphy. Intima-media thickness was mainly influenced by age and hypertension.
  
  
  CONCLUSIONS
  In this study, neither intima-media thickness measurements, nor classic risk factors could improve the diagnostic value of stress ECG in the detection of coronary artery disease. In case of equivocal stress results, additional cardiovascular imaging techniques remain recommended.
authors.affiliation: Department of Cardiology, University Hospital of Antwerp, Edegem, Belgium. hilde.heuten@uza.be
authors.forename: Hilde
authors.initials: H
authors.lastname: Heuten
authors.forename: Marc
authors.initials: M
authors.lastname: Claeys
authors.forename: Inge
authors.initials: I
authors.lastname: Goovaerts
authors.forename: Guy
authors.initials: G
authors.lastname: Ennekens
authors.forename: Johan
authors.initials: J
authors.lastname: Bosmans
authors.forename: Christiaan
authors.initials: C
authors.lastname: Vrints
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure; D017536:Carotid Artery, Common / Q000000981:diagnostic imaging / Q000473:pathology*; D016893:Carotid Stenosis / Q000150:complications / Q000175:diagnosis* / Q000453:epidemiology / Q000503:physiopathology; D003324:Coronary Artery Disease / Q000150:complications / Q000175:diagnosis* / Q000453:epidemiology / Q000503:physiopathology; D004562:Electrocardiography; D005080:Exercise Test; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015588:Observer Variation; D011237:Predictive Value of Tests; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D012044:Regression Analysis; D012307:Risk Factors; D017256:Technetium Tc 99m Sestamibi; D017539:Tunica Intima / Q000000981:diagnostic imaging / Q000473:pathology*; D017540:Tunica Media / Q000000981:diagnostic imaging / Q000473:pathology*; D018084:Ultrasonography, Interventional
chemical_list: D015415:Biomarkers; D019275:Radiopharmaceuticals; D017256:Technetium Tc 99m Sestamibi