Crosstalk of DNA glycosylases with pathways other than base excision repair.
While a role for DNA glycosylase activity in base excision repair (BER) is well understood, there is mounting evidence to implicate cooperation of DNA glycosylases with components of repair pathways other than BER. The mechanisms by which DNA glycosylases interact with non-BER pathways are, in many cases, poorly understood. However, accumulating evidence indicates that crosstalk is common and may be as important in signaling repair as the canonical pathways themselves.
Kovtun
Irina V
IV
Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic Rochester, 721C Guggenheim Bldg, 200 First Street, Rochester, MN 55905, USA.
McMurray
Cynthia T
CT
D000818:Animals; D004249:DNA Damage; D045647:DNA Glycosylases / Q000378:metabolism*; D053843:DNA Mismatch Repair; D004260:DNA Repair; D045643:DNA Repair Enzymes / Q000378:metabolism*; D051379:Mice; D009711:Nucleotides / Q000378:metabolism; D010084:Oxidation-Reduction; D014158:Transcription, Genetic
D009711:Nucleotides; D045647:DNA Glycosylases; D045643:DNA Repair Enzymes