title: Altered in vitro immune response to hypoxia-treated normal peritoneal fibroblasts.
abstract: Hypoxia treatment of normal peritoneal fibroblasts results in alterations that are characteristic for fibroblasts obtained from postoperative peritoneal adhesion tissue. In this study, we have shown that hypoxia treatment enhances normal peritoneal fibroblast elimination by lymphokine-activated killer cells to the level of adhesion tissue fibroblasts, suggesting a pivotal role of hypoxia in the adhesion development.
authors.affiliation: Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Hutzel Hospital, Wayne State University, Detroit, Michigan 48201, USA.
authors.forename: Zeynep
authors.initials: Z
authors.lastname: Alpay
authors.forename: Melike
authors.initials: M
authors.lastname: Ozgönenel
authors.forename: Süreyya
authors.initials: S
authors.lastname: Savaşan
authors.forename: Steven
authors.initials: S
authors.lastname: Buck
authors.forename: Ghassan M
authors.initials: GM
authors.lastname: Saed
authors.forename: Michael P
authors.initials: MP
authors.lastname: Diamond
mesh_terms: D000222:Adaptation, Physiological / Q000276:immunology; D002448:Cell Adhesion / Q000276:immunology*; D002450:Cell Communication / Q000276:immunology; D015687:Cell Hypoxia / Q000276:immunology; D002478:Cells, Cultured; D005347:Fibroblasts / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology*; D007155:Immunologic Factors / Q000276:immunology*; D015979:Killer Cells, Lymphokine-Activated / Q000276:immunology*; D010537:Peritoneum / Q000166:cytology* / Q000276:immunology*
chemical_list: D007155:Immunologic Factors