title: Changes of cholinesterase activities in the plasma and some tissues following administration of L-carnitine and galanthamine to rats.
abstract: Changes of acetylcholinesterase (AChE) activities in the hypophysis and brain (frontal cortex, hippocampus, medial septum and basal ganglia), and butyrylcholinesterase in plasma and liver following galanthamine (GAL) administration were studied in rats pretreated with L-carnitine (CAR). Following only GAL administration (10 mg/kg, i.m.), both cholinesterases (without clinical symptoms of GAL overdosage) were significantly inhibited. Pretreatment with CAR (3 consecutive days, 250 mg/kg, p.o.) followed by GAL administration showed higher AChE inhibition in comparison with single GAL administration. However, a statistically significant difference was observed for AChE in the hippocampus only. The activity of peripheral cholinesterases was not influenced by CAR pretreatment. Thus, pretreatment with CAR enhanced AChE inhibition in some brain parts of the rat following GAL administration.
authors.affiliation: Faculty of Military Health Sciences, University of Defence, and Institute of Clinical Biochemistry and Diagnostic, Faculty Hospital, Hradec Kralove, Czech Republic. bajgar@pmfhk.cz
authors.forename: Jiri
authors.initials: J
authors.lastname: Bajgar
authors.forename: Lucie
authors.initials: L
authors.lastname: Bartosova
authors.forename: Josef
authors.initials: J
authors.lastname: Fusek
authors.forename: Zdenek
authors.initials: Z
authors.lastname: Svoboda
authors.forename: Josef
authors.initials: J
authors.lastname: Herink
authors.forename: Jaroslav
authors.initials: J
authors.lastname: Kvetina
authors.forename: Vladimir
authors.initials: V
authors.lastname: Palicka
authors.forename: Pavel
authors.initials: P
authors.lastname: Zivny
authors.forename: Vaclav
authors.initials: V
authors.lastname: Blaha
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects*; D002091:Butyrylcholinesterase / Q000097:blood; D002331:Carnitine / Q000008:administration & dosage*; D002800:Cholinesterase Inhibitors / Q000008:administration & dosage*; D002802:Cholinesterases / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D004789:Enzyme Activation / Q000187:drug effects; D005702:Galantamine / Q000008:administration & dosage*; D016014:Linear Models; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D014803:Vitamin B Complex / Q000008:administration & dosage*
chemical_list: D002800:Cholinesterase Inhibitors; D005702:Galantamine; D014803:Vitamin B Complex; D002091:Butyrylcholinesterase; D002802:Cholinesterases; D002331:Carnitine