title: Osteopontin: a novel inflammatory mediator of cardiovascular disease.
abstract: Osteopontin, also called cytokine Eta-1, is a multifunctional protein containing Arg-Gly-Asp-Ser (RGDS) cell-binding sequence. It interacts with alpha(v)beta1, alpha(v)beta3 and alpha(v)beta5 integrins and CD44 receptors. OPN is suggested to play a role during inflammation via the recruitment and retention of macrophages and T-cells to inflamed sites. OPN regulates the production of inflammatory cytokines and nitric oxide in macrophages. In this review, we will discuss diverse roles of OPN related to cardiovascular diseases, including atherosclerosis, valvular stenosis, hypertrophy, myocardial infarction and heart failure.
authors.affiliation: Department of Physiology, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA. singhm@etsu.edu
authors.forename: Mahipal
authors.initials: M
authors.lastname: Singh
authors.forename: Srinivas
authors.initials: S
authors.lastname: Ananthula
authors.forename: Denise M
authors.initials: DM
authors.lastname: Milhorn
authors.forename: Guha
authors.initials: G
authors.lastname: Krishnaswamy
authors.forename: Krishna
authors.initials: K
authors.lastname: Singh
mesh_terms: D000818:Animals; D002318:Cardiovascular Diseases / Q000175:diagnosis / Q000209:etiology* / Q000276:immunology; D006331:Heart Diseases / Q000209:etiology; D006801:Humans; D018836:Inflammation Mediators / Q000737:chemistry / Q000502:physiology; D053495:Osteopontin / Q000737:chemistry / Q000502:physiology*; D014652:Vascular Diseases / Q000209:etiology
chemical_list: D018836:Inflammation Mediators; D053495:Osteopontin