title: The effect of angle on wall shear stresses in a LIMA to LAD anastomosis: numerical modelling of pulsatile flow.
abstract: The purpose of this study was to examine the effect of anastomotic angle on the flow patterns and wall shear distributions at the distal anastomosis of a left interior mammary artery (LIMA) graft to the left anterior descending artery (LDA). It is now well recognized that abnormal wall shear stress distributions along the anastomotic bed, around the toe, and around the heel can contribute to the focal development of intimal hyperplasia. However, the exact nature of the interaction between the dominant pulsing flow and the anastomotic angle on wall shear stresses has not been fully investigated numerically. In this study a commercial CFD package was used for three-dimensional flow analysis where the pulsatile waveforms and flowrates used as the boundary conditions are representative of an anastomosed left internal mammary artery and a stenosed left anterior descending coronary artery (intermediate, <70 per cent diameter narrowing). The flow patterns and distributions of time-averaged wall shear stress (TAWSS) and the oscillatory shear index (OSI) for three anastomotic angles of 20, 40, and 60 degrees were evaluated and compared with other published data. The findings indicated that transient, highly disturbed flow patterns occurred in localized regions of the proximal and distal native segments and in the anastomotic domain including recirculation zones, moving points of stagnation, and oscillating wall shear stresses mainly on the bed, at the toe, and at the heel. Moreover, higher anastomotic angles resulted in more extreme variations in TAWSS and OSI values, particularly around the toe and along the bed. In addition, the effect of anastomotic angle on OSI values at the heel followed the same pattern whereas the TAWSS values along the graft at the heel showed a significant increase at the lowest anastomotic angle of 20 degrees.
authors.affiliation: Faculty of Engineering, Swinburne University of Technology, Melbourne, Victoria, Australia. ifreshwa@bigpond.net.au
authors.forename: I J
authors.initials: IJ
authors.lastname: Freshwater
authors.forename: Y S
authors.initials: YS
authors.lastname: Morsi
authors.forename: T
authors.initials: T
authors.lastname: Lai
mesh_terms: D000714:Anastomosis, Surgical / Q000379:methods*; D001783:Blood Flow Velocity / Q000502:physiology; D001794:Blood Pressure / Q000502:physiology; D003198:Computer Simulation; D001026:Coronary Artery Bypass / Q000379:methods; D003331:Coronary Vessels / Q000503:physiopathology* / Q000601:surgery*; D006801:Humans; D008323:Mammary Arteries / Q000503:physiopathology* / Q000601:surgery*; D008955:Models, Cardiovascular; D011673:Pulsatile Flow / Q000502:physiology*; D033081:Shear Strength