Isolated amyloidosis presenting with lumbosacral radiculoplexopathy: description of two cases and pathogenic review.
In this study, we present two cases of infiltrative, localized amyloidosis involving lumbosacral root and plexus, e.g., isolated amyloidomas. Rare and poorly understood amyloidomas may occur in both neurologic and non-neurologic tissues. The described cases emphasize potential for localized peripheral amyloidomas: (1) potential for associated lambda light chain lymphoplasmacytic lymphoma association; (2) e isolated amyloidosis without evidence for systemic plasma cell dyscrasia; (3) features suggestive of potential pathogenesis; and (4) discussion of treatment options including immunotherapy and resection. The limited literature and experience among other cases is described.
Ladha
Shafeeq S
SS
Department of Neurology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA.
Dyck
P James B
PJ
Spinner
Robert J
RJ
Perez
Domingo G
DG
Zeldenrust
Steven R
SR
Amrami
Kimberly K
KK
Solomon
Alan
A
Klein
Christopher J
CJ
D000368:Aged; D017772:Amyloid Neuropathies / Q000150:complications / Q000473:pathology* / Q000503:physiopathology*; D000686:Amyloidosis / Q000150:complications / Q000473:pathology* / Q000503:physiopathology*; D002420:Cauda Equina / Q000473:pathology; D003937:Diagnosis, Differential; D004594:Electrophysiology; D006801:Humans; D007147:Immunoglobulin Light Chains; D007150:Immunohistochemistry; D008160:Lumbosacral Plexus / Q000473:pathology*; D008161:Lumbosacral Region; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D008998:Monoclonal Gammopathy of Undetermined Significance / Q000150:complications; D011843:Radiculopathy / Q000209:etiology*; D012584:Sciatic Nerve / Q000473:pathology
D007147:Immunoglobulin Light Chains