Two new dioxopiperazine derivatives, arestrictins A and B, isolated from Aspergillus restrictus and Aspergillus penicilloides.
In the course of searching for bioactive substances, two new dioxopiperazine derivatives, arestrictins A (1) and B (2), were isolated along with the known dioxopiperazine, cristatin A (3), and the known peptide, asperglucide (4), from the organic extract of the xerophilic fungi, Aspergillus restrictus and Aspergillus penicilloides. The absolute structures of 1 and 2, except for the configuration of the secondary alcohol in 1, were established by spectroscopic and chemical investigation. The absolute configuration of cristatin A (3) was also determined.
Itabashi
Takeshi
T
Faculty of Pharmaceutical Sciences, Hoshi University, Tokyo, Japan.
Matsuishi
Natsuna
N
Hosoe
Tomoo
T
Toyazaki
Norihiro
N
Udagawa
Shun-Ichi
S
Imai
Toshimichi
T
Adachi
Mitsuru
M
Kawai
Ken-Ichi
K
D001230:Aspergillus / Q000737:chemistry*; D015394:Molecular Structure; D000077489:Piperazine; D010879:Piperazines / Q000737:chemistry*; D014364:Tryptophan / Q000031:analogs & derivatives* / Q000737:chemistry
D010879:Piperazines; C516810:arestrictin A; C516811:arestrictin B; D000077489:Piperazine; D014364:Tryptophan