title: Synthesis of OSW saponin analogs with modified sugar residues and their antiproliferative activities.
abstract: Eight monosaccharide analogs of the potent antitumor OSW saponins (2-9) were synthesized. One analog, 2-O-acetyl-alpha-l-arabinopyranoside 3, showed antiproliferative activity against the Jurkat cells (IC(50)=0.078microM) comparable to that of the disaccharide derivative (1).
authors.affiliation: State Key Laboratory of Bio-organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China.
authors.forename: Pingping
authors.initials: P
authors.lastname: Tang
authors.forename: Fatemah
authors.initials: F
authors.lastname: Mamdani
authors.forename: Xiaoyi
authors.initials: X
authors.lastname: Hu
authors.forename: Jun O
authors.initials: JO
authors.lastname: Liu
authors.forename: Biao
authors.initials: B
authors.lastname: Yu
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis* / Q000494:pharmacology*; D002241:Carbohydrates / Q000737:chemistry*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002783:Cholestenones / Q000138:chemical synthesis* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D006801:Humans; D007202:Indicators and Reagents; D019169:Jurkat Cells; D031442:Ornithogalum / Q000737:chemistry*; D012503:Saponins / Q000138:chemical synthesis* / Q000494:pharmacology*; D013936:Thymidine / Q000378:metabolism
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D002241:Carbohydrates; D002783:Cholestenones; D007202:Indicators and Reagents; D012503:Saponins; C106408:OSW 1; D013936:Thymidine