title: MCI is associated with deficits in everyday functioning.
abstract: The purpose of the present study was to examine the types of impairments in everyday function that accompany mild cognitive impairment (MCI). Data for this study was collected from 434 individuals consecutively evaluated at a university-based Alzheimer's Center. A total of 96 participants were diagnosed with MCI, 105 were cognitively normal, and 233 had dementia. Informant ratings of participants' abilities were obtained across different functional domains reflecting everyday abilities related to memory, language, visual spatial abilities, planning, organization, and divided attention. As expected, the demented group was significantly more impaired than the healthy control and MCI groups across all of the functional domains. The MCI group also showed significantly more functional impairment relative to healthy controls in all of the functional domains. Examination of the effect sizes as a measure of the magnitude of functional impairment in the MCI groups relative to controls showed that the greatest degree of impairment occurred within the Everyday Memory domain. The current findings suggest that individuals with MCI demonstrate deficits in a wide range of everyday functions but that the magnitude of these changes is greatest for those functional abilities that rely heavily on memory.
authors.affiliation: Department of Neurology, University of California, Davis, CA, USA. sarah.farias@ucdmc.ucdavis.edu
authors.forename: Sarah T
authors.initials: ST
authors.lastname: Farias
authors.forename: Dan
authors.initials: D
authors.lastname: Mungas
authors.forename: Bruce R
authors.initials: BR
authors.lastname: Reed
authors.forename: Danielle
authors.initials: D
authors.lastname: Harvey
authors.forename: Deborah
authors.initials: D
authors.lastname: Cahn-Weiner
authors.forename: Charles
authors.initials: C
authors.lastname: Decarli
mesh_terms: D000203:Activities of Daily Living; D000368:Aged; D000375:Aging / Q000502:physiology*; D000544:Alzheimer Disease / Q000503:physiopathology; D003072:Cognition Disorders / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests