Blastic natural killer cell leukaemia in a dog--a case report.
A case of canine non-T, non-B lymphoid leukaemia was determined to be of natural killer (NK) cell lineage by detecting specific expression of canine CD56 mRNA by reverse transcriptase polymerase chain reaction analysis. Although NK cells are usually considered to be morphologically large granular lymphocytes, the malignant NK cells in this case were agranular and blast-like, resembling human blastic NK cell leukaemia. The prognosis of human NK cell leukaemia is usually poor. In this case, the dog died 10 days after initial presentation, despite chemotherapy.
Bonkobara
Makoto
M
Department of Veterinary Clinical Pathology, Nippon Veterinary and Life Science University, 1-7-1 Kyonan-cho, Musashino-shi, Tokyo 180-8602, Japan. bonkobara@nvlu.ac.jp
Saito
Taro
T
Yamashita
Masahiro
M
Tamura
Kyoichi
K
Yagihara
Hiroko
H
Isotani
Mayu
M
Sato
Takashi
T
Washizu
Tsukimi
T
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D019002:CD56 Antigen / Q000235:genetics / Q000378:metabolism; D004283:Dog Diseases / Q000175:diagnosis* / Q000188:drug therapy; D004285:Dogs; D004317:Doxorubicin / Q000627:therapeutic use; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D054066:Leukemia, Large Granular Lymphocytic / Q000175:diagnosis / Q000188:drug therapy / Q000662:veterinary*; D012333:RNA, Messenger / Q000235:genetics; D014750:Vincristine / Q000627:therapeutic use
D000970:Antineoplastic Agents; D019002:CD56 Antigen; D012333:RNA, Messenger; D014750:Vincristine; D004317:Doxorubicin