The role of the granulocyte colony-stimulating factor receptor (G-CSF-R) in disease.
Granulocyte colony-stimulating factor (G-CSF) is a key regulator of granulopoiesis via stimulation of a specific cell-surface receptor, the G-CSF-R, found on hematopoietic progenitor cells as well as neutrophilic granulocytes. It is perhaps not surprising, therefore, that mutations of the G-CSF-R has been implicated in several clinical settings that affect granulocytic differentiation, particularly severe congenital neutropenia, myelodysplastic syndrome and acute myeloid leukemia. However, other studies suggest that signalling via the G-CSF-R is also involved in a range of other malignancies. This review focuses on the molecular mechanisms through which the G-CSF-R contributes to disease.
Ward
Alister C
AC
School of Life and Environmental Sciences, Deakin University, Burwood, Victoria, Australia. award@deakin.edu.au
D000208:Acute Disease; D000818:Animals; D016179:Granulocyte Colony-Stimulating Factor / Q000502:physiology; D006801:Humans; D007951:Leukemia, Myeloid / Q000235:genetics; D051379:Mice; D009154:Mutation; D009190:Myelodysplastic Syndromes / Q000235:genetics*; D009369:Neoplasms / Q000235:genetics; D009503:Neutropenia / Q000151:congenital / Q000235:genetics*; D016188:Receptors, Granulocyte Colony-Stimulating Factor / Q000235:genetics* / Q000502:physiology
D016188:Receptors, Granulocyte Colony-Stimulating Factor; D016179:Granulocyte Colony-Stimulating Factor