[Spontaneous discharge modulation by acetylcholine in chronically compressed rat dorsal root ganglion neurons].
OBJECTIVE
To study the effects of acetylcholine (ACh) on spontaneous discharges of compressed rat dorsal root ganglion (DRG) neurons.


METHODS
In chronically compressed DRG model, the spontaneous discharge of a single fiber from the DRG neuron in response to ACh treatment was recorded.


RESULTS
Active spontaneous discharges were recorded in the injured DRG, and 77.9% of the injured DRG neurons responded to Ach treatment in the manner of simple excitation, or excitation followed by inhibition. The responses were enhanced with the increase of Ach concentration.


CONCLUSIONS
Injured DRG remains active in spontaneous discharges, which can be significantly influenced by ACh treatment.
Yang
Hong-Jun
HJ
Department of Neurology, Guangzhou General Hospital of Guangzhou Command, Guangzhou 510010, China. sjnkyhj@163.com
Hu
San-Jue
SJ
D000109:Acetylcholine / Q000494:pharmacology*; D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D005727:Ganglia, Spinal / Q000503:physiopathology*; D008297:Male; D009408:Nerve Compression Syndromes / Q000503:physiopathology*; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors; D014665:Vasodilator Agents / Q000494:pharmacology
D014665:Vasodilator Agents; D000109:Acetylcholine