Altered in vitro immune response to hypoxia-treated normal peritoneal fibroblasts.
Hypoxia treatment of normal peritoneal fibroblasts results in alterations that are characteristic for fibroblasts obtained from postoperative peritoneal adhesion tissue. In this study, we have shown that hypoxia treatment enhances normal peritoneal fibroblast elimination by lymphokine-activated killer cells to the level of adhesion tissue fibroblasts, suggesting a pivotal role of hypoxia in the adhesion development.
Alpay
Zeynep
Z
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Hutzel Hospital, Wayne State University, Detroit, Michigan 48201, USA.
Ozgönenel
Melike
M
Savaşan
Süreyya
S
Buck
Steven
S
Saed
Ghassan M
GM
Diamond
Michael P
MP
D000222:Adaptation, Physiological / Q000276:immunology; D002448:Cell Adhesion / Q000276:immunology*; D002450:Cell Communication / Q000276:immunology; D015687:Cell Hypoxia / Q000276:immunology; D002478:Cells, Cultured; D005347:Fibroblasts / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology*; D007155:Immunologic Factors / Q000276:immunology*; D015979:Killer Cells, Lymphokine-Activated / Q000276:immunology*; D010537:Peritoneum / Q000166:cytology* / Q000276:immunology*
D007155:Immunologic Factors