Genome-wide identification of conserved longevity genes in yeast and worms.
Technological advancements in invertebrate model organisms have recently made it possible to survey many or all of the genes in the genome for phenotypes of interest. In both C. elegans and S. cerevisiae, genome-wide searches for hypomorphic mutations that extend life span have been performed. The results from these screens are starting to provide a more complete view of the range of life span determinants in eukaryotes. In addition, it is becoming possible to test the premise that conserved aging genes and pathways regulate aging in disparate eukaryotic species. Here we compare and contrast the results from genome-wide aging screens and assess the likelihood that there are "public" aging mechanisms.
Smith
Erica D
ED
Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.
Kennedy
Brian K
BK
Kaeberlein
Matt
M
D000818:Animals; D001483:Base Sequence; D017173:Caenorhabditis elegans / Q000235:genetics*; D017124:Conserved Sequence / Q000235:genetics*; D016678:Genome / Q000502:physiology*; D008136:Longevity / Q000235:genetics*; D012441:Saccharomyces cerevisiae / Q000235:genetics*