Synthesis of a versatile constrained analogue of dipeptide DG (Asp-Gly).
The synthesis of an orthogonally protected constrained analogue of dipeptide DG (Asp-Gly) is reported exploiting alkylation of a chiral lactam. The versatility of this analogue was proven by removal of t-Boc protecting group, followed by coupling under homogeneous conditions with t-Boc-Arg(Z(2))-Gly, to give a conformationally restricted analogue of RGDG tetrapeptide.
Galeazzi
R
R
Dipartimento di Scienze dei Materiali e della Terra, Università Politecnica delle Marche, Ancona, Italy.
Marcucci
E
E
Martelli
G
G
Natali
D
D
Orena
M
M
Rinaldi
S
S
D032701:Biomimetics; D004151:Dipeptides / Q000138:chemical synthesis*
D004151:Dipeptides; C017033:aspartylglycine