title: [Primary prevention of gastroduodenal ulcer: what is the evidence?].
abstract: Primary prevention of gastroduodenal ulcer and its major complication, gastrointestinal bleeding, has been studied mainly in the intensive care environment. Proton pump inhibitors (PPIs), H2-receptor antagonists and sucralfate have proved effective. By extension, PPIs are inappropriately prescribed in a variety of clinical situations. In contrast, they are probably underused in patients chronically treated by nonsteroidal anti-inflammatory drugs. This article reviews the situations in which an increased ulcer risk justifies primary prevention. Validated prophylactic options are also addressed.
authors.affiliation: Service de médecine interne générale HUG, 1211 Genève.
authors.forename: S
authors.initials: S
authors.lastname: Pfaender
authors.forename: A
authors.initials: A
authors.lastname: Perrier
authors.forename: M
authors.initials: M
authors.lastname: Nendaz
mesh_terms: D000369:Aged, 80 and over; D000897:Anti-Ulcer Agents / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010437:Peptic Ulcer / Q000517:prevention & control*; D011322:Primary Prevention; D012307:Risk Factors
chemical_list: D000897:Anti-Ulcer Agents