Cardioprotective effect of edaravone against ischaemia-reperfusion injury in the rabbit heart before, during and after reperfusion treatment.
The free radical scavenger edaravone is able to stimulate prostacyclin release and inhibit the lipoxygenase pathway in the arachidonic acid cascade. The effect of edaravone administration on myocardial damage in rabbit hearts subjected to ischaemia-reperfusion was examined at different times relative to reperfusion. All rabbits underwent sustained coronary artery occlusion for 30 min followed by 3 h of reperfusion. Rabbits were divided into the following groups: control; early (3 mg/kg edaravone IV 10 min before reperfusion); immediate (3 mg/kg edaravone IV immediately after the start of reperfusion); and late (3, 6 or 10 mg/kg edaravone IV 5 min after the start of reperfusion). Single bolus administration of edaravone 10 min before reperfusion or immediately upon initiation of reperfusion appears to be associated with reductions in infarction size and the percentage of apoptotic cells, but treatment with edaravone 5 min after initiation of reperfusion does not appear to have this protective effect.
Fukuda
A
A
Department of Cardiology, Tokyo Medical University Kasumigaura Hospital, Ami, Ibaraki, Japan.
Okubo
S
S
Tanabe
Y
Y
Hoshiba
Y
Y
Shiobara
H
H
Harafuji
K
K
Kobori
Y
Y
Fujinawa
M
M
Okubo
T
T
Yamashina
A
A
D000818:Animals; D000983:Antipyrine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects; D002316:Cardiotonic Agents / Q000008:administration & dosage* / Q000494:pharmacology; D053938:DNA Fragmentation / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D000077553:Edaravone; D016166:Free Radical Scavengers / Q000627:therapeutic use; D009203:Myocardial Infarction / Q000188:drug therapy / Q000517:prevention & control; D015428:Myocardial Reperfusion Injury / Q000188:drug therapy / Q000473:pathology / Q000517:prevention & control*; D011817:Rabbits; D013997:Time Factors
D002316:Cardiotonic Agents; D016166:Free Radical Scavengers; D000077553:Edaravone; D000983:Antipyrine