mRNA transport to and translation in neuronal dendrites.
Transport of mRNA is an important biological process in all cells that sets up gradients of translated protein from the site of mRNA docking and translation. Neurons are highly polarized cells where the targeted movement of RNAs and local translation at that site have been shown to be integral to the proper functioning of the neuron. Indeed, this specialized biological function for localized RNAs in particular neurons may in part confer a selective advantage on these cells such that they "out-compete" others in the race to establish synaptic connectivity. In this mini-review we highlight some of the salient features of RNA targeting and translation in neurons.
Wu
Chia-wen K
CW
Department of Pharmacology, University of Pennsylvania Medical School, 36th and Hamilton Walk, Philadelphia, PA 19104, USA.
Zeng
Fanyi
F
Eberwine
James
J
D000818:Animals; D003712:Dendrites / Q000378:metabolism* / Q000502:physiology; D006801:Humans; D008954:Models, Biological; D009474:Neurons / Q000378:metabolism* / Q000502:physiology; D014176:Protein Biosynthesis; D034443:RNA Transport / Q000502:physiology; D016601:RNA-Binding Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology
D016601:RNA-Binding Proteins