The permeation of nalmefene hydrochloride across different regions of ovine nasal mucosa.
The permeability of nalmefene hydrochloride (NH) across different regions of ovine nasal mucosa was investigated in vitro. Five different regions of ovine nasal mucosa (superior turbinate mucosa, middle turbinate mucosa, inferior turbinate mucosa, posterior septum mucosa, and anterior septum mucosa) were studied. The results showed that the permeability coefficients of NH through different regions of nasal mucosa were different, and the suitable regions for the absorption of NH were the middle turbinate mucosa, the posterior septum mucosa and the superior turbinate. At the same time, the middle turbinate mucosa was the largest region among the five regions, thus it was the main absorption region for NH. The high uniformity of the middle turbinate mucosa also made it the most suitable model for the permeation of NH in vitro.
Du
Gani
G
Department of Pharmacy, School of Pharmaceutical Science, Shenyang Pharmaceutical University, Shenyang, Japan.
Gao
Yongliang
Y
Nie
Shufang
S
Pan
Weisan
W
D000818:Animals; D001692:Biological Transport; D002463:Cell Membrane Permeability; D008297:Male; D009271:Naltrexone / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D009297:Nasal Mucosa / Q000033:anatomy & histology / Q000187:drug effects*; D012756:Sheep; D014420:Turbinates / Q000033:anatomy & histology
D009271:Naltrexone; C038981:nalmefene