title: Addison's disease presenting as acute chest syndrome: case report and review of literature.
abstract: BACKGROUND
  Addison's disease is due to primary adrenal failure. It is an uncommon condition with equal prevalence in both males and females. The onset of symptoms is gradual and manifestation is non specific, hence diagnosis is easily missed without a high index of suspicion.
  
  
  METHODS
  The medical records of a patient who presented with acute chest pain to the cardiac unit of the University of Port Harcourt Teaching Hospital were reviewed. A review of the literature using manual library and Medline search on Addison's disease was also done.
  
  
  RESULTS
  A 48 years old male presented in our medical outpatient department with a three day history of sudden onset of severe precordial chest pain that started while playing football which was associated with nausea, vomiting and difficulty in breathing. After initial clinical evaluation a diagnosis of acute myocardial infarction and cardiac failure with a suspicion of background Addison's disease was made. Serial electrocardiography done over a two week period did not show evidence of myocardial infarction, but the patient had elevated serum ACTH and very low serum cortisol levels. An abdominal CT scan done two weeks after admission showed absence of the Adrenal glands bilaterally, confirming Addison's disease. He received treatment for cardiac failure, analgesics, prednisolone and a mineralocorticoid to which he responded satisfactorily and has remained healthy. He also received a six months course of antituberculous treatment empirically.
  
  
  CONCLUSIONS
  Addison's disease is an uncommon endocrine disorder which can present insidiously in a non specific manner. Diagnosis requires a high index of suspicion.
authors.affiliation: Department of Internal Medicine, University of Port Harcourt Teaching Hospital, Port Harcourt, Nigeria.
authors.forename: M R
authors.initials: MR
authors.lastname: Akpa
authors.forename: O J
authors.initials: OJ
authors.lastname: Odia
mesh_terms: D000208:Acute Disease; D000224:Addison Disease / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology; D002637:Chest Pain / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology; D003937:Diagnosis, Differential; D006801:Humans; D008297:Male; D008875:Middle Aged; D008901:Mineralocorticoids / Q000627:therapeutic use; D011239:Prednisolone / Q000627:therapeutic use
chemical_list: D008901:Mineralocorticoids; D011239:Prednisolone