Amniocentesis results and novel proteomic analysis in a case of occult candidal chorioamnionitis.
We report a case of subclinical Candida albicans chorioamnionitis with mid-trimester cervical dilation diagnosed by amniotic fluid culture and Gram stain. Proteomic analysis of amniotic fluid demonstrated protein biomarkers previously associated only with bacterial intra-amniotic infections. We hypothesize that since amniotic fluid culture of yeast may take days, novel tests such as proteomic profiling may lead to the development of rapid diagnostic tests for fungal intra-amniotic infections.
Crawford
Julie T
JT
Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, OR, USA. crawforj@ohsu.edu
Pereira
Leonardo
L
Buckmaster
John
J
Gravett
Michael G
MG
Tolosa
Jorge E
JE
D000328:Adult; D000649:Amniocentesis; D000935:Antifungal Agents / Q000627:therapeutic use; D002177:Candidiasis / Q000175:diagnosis* / Q000188:drug therapy / Q000378:metabolism*; D002821:Chorioamnionitis / Q000175:diagnosis* / Q000188:drug therapy / Q000378:metabolism / Q000382:microbiology*; D005260:Female; D015725:Fluconazole / Q000627:therapeutic use; D006801:Humans; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000175:diagnosis* / Q000188:drug therapy; D011264:Pregnancy Trimesters; D040901:Proteomics
D000935:Antifungal Agents; D015725:Fluconazole