Multistep resistance selection and postantibiotic-effect studies of the antipneumococcal activity of LBM415 compared to other agents.
LBM415 is a peptide deformylase inhibitor active against gram-positive bacterial species and some gram-negative species. In multiselection studies, LBM415 had low MICs against all Streptococcus pneumoniae strains tested, regardless of their genotype, and selected resistant clones after 14 to 50 days. MIC increases correlated with changes mostly in the 70GXGXAAXQ77 motif in peptide deformylase. The postantibiotic effect of LBM415 ranged from 0.3 to 1.4 h.
Kosowska-Shick
Klaudia
K
Department of Pathology, Hershey Medical Center, P.O. Box 850, Hershey, PA 17033, USA.
Credito
Kim L
KL
Pankuch
Glenn A
GA
DeWasse
Bonifacio
B
McGhee
Pamela
P
Appelbaum
Peter C
PC
D000581:Amidohydrolases / Q000235:genetics; D024881:Drug Resistance, Bacterial / Q000235:genetics; D008826:Microbial Sensitivity Tests; D010455:Peptides / Q000235:genetics / Q000494:pharmacology*; D011008:Pneumococcal Infections / Q000188:drug therapy; D013045:Species Specificity; D013296:Streptococcus pneumoniae / Q000187:drug effects* / Q000235:genetics; D013997:Time Factors
C487638:NVP PDF 713; D010455:Peptides; D000581:Amidohydrolases; C084507:peptide deformylase