title: The mirror neuron system and the consequences of its dysfunction.
abstract: The discovery of premotor and parietal cells known as mirror neurons in the macaque brain that fire not only when the animal is in action, but also when it observes others carrying out the same actions provides a plausible neurophysiological mechanism for a variety of important social behaviours, from imitation to empathy. Recent data also show that dysfunction of the mirror neuron system in humans might be a core deficit in autism, a socially isolating condition. Here, we review the neurophysiology of the mirror neuron system and its role in social cognition and discuss the clinical implications of mirror neuron dysfunction.
authors.affiliation: Ahmanson-Lovelace Brain Mapping Center, Department of Psychiatry and Biobehavioural Sciences, Neuropsychiatric Institute, Brain Research Institute, David Geffen School of Medicine, University of California, Los Angeles 90095, USA. iacoboni@ucla.edu
authors.forename: Marco
authors.initials: M
authors.lastname: Iacoboni
authors.forename: Mirella
authors.initials: M
authors.lastname: Dapretto
mesh_terms: D000818:Animals; D001321:Autistic Disorder / Q000503:physiopathology / Q000523:psychology; D002540:Cerebral Cortex / Q000033:anatomy & histology / Q000502:physiology; D004645:Empathy; D006801:Humans; D007100:Imitative Behavior / Q000502:physiology; D009434:Neural Pathways / Q000033:anatomy & histology / Q000502:physiology; D009474:Neurons / Q000502:physiology; D011597:Psychomotor Performance / Q000502:physiology; D012919:Social Behavior; D012920:Social Behavior Disorders / Q000503:physiopathology* / Q000523:psychology