Potential cytotoxic activity of some Brazilian seaweeds on human melanoma cells.
In vitro screening of the crude extracts of some Brazilian coastal seaweeds for cytotoxic activity against a cultured human melanoma cancer cell line using the sulphorhodamine B assay was performed. The crude dichloromethane:chloroform extract of Stypopodium zonale showed good cytotoxic activity against the C32 cell line. The crude acetone extract and aqueous phase of Lobophora variegata did not show any activity, but semi-purified fractions XAD LOB I and II could inhibit the growth of melanoma cells. The crude acetone extract of Caulerpa racemosa showed some cytotoxicity, but caulerpin isolated from this extract did not show any such activity. The crude acetone extract of Spatoglossum schroederi was not able to inhibit the growth of C32 melanoma cells.
Rocha
Fabíola Dutra
FD
Programa de Pós-graduação de Produtos Naturais, Núcleo de Pesquisas de Produtos Naturais, Universidade Federal do Rio de Janeiro, RJ, 21941-590, Brazil. fabioladutrarocha@hotmail.com
Soares
Angélica Ribeiro
AR
Houghton
Peter John
PJ
Pereira
Renato Crespo
RC
Kaplan
Maria Auxiliadora Coelho
MA
Teixeira
Valéria Laneuville
VL
D000972:Antineoplastic Agents, Phytogenic / Q000627:therapeutic use / Q000633:toxicity*; D017209:Apoptosis / Q000187:drug effects; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D006801:Humans; D008545:Melanoma / Q000188:drug therapy*; D010936:Plant Extracts / Q000627:therapeutic use / Q000633:toxicity; D012624:Seaweed / Q000737:chemistry*
D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts