title: Impact of ethanol dosing on the long-term outcome of alcohol septal ablation for obstructive hypertrophic cardiomyopathy: a single-center prospective, and randomized study.
abstract: BACKGROUND
  The impact of ethanol dose on the long-term outcome of alcohol septal ablation (ASA) for obstructive hypertrophic cardiomyopathy was investigated.
  
  
  RESULTS
  Fifty-four patients (age 24-82 years; 65% women) undergoing ASA were randomized into 2 groups according to the dose of injected ethanol: Group A 1-2 ml, Group B >2 ml. Clinical and echocardiographic data were obtained at baseline and during follow-up. The volume of ethanol injected was 1.50+/-0.4 and 2.60+/-0.6 ml (p<0.001) with a subsequent peak of creatine kinase-MB of 2.25+/-1.00 and 2.62+/-1.57 microkat/L (p=0.02) in Groups A and B, respectively. The median follow-up was 39 (range 6-72) months after ASA, during which 1 patient died and 1 repeat procedure was necessary in both groups of patients. Both groups had a significant and similar improvement in outflow pressure gradient, dyspnea (New York Heart Association functional class) and angina pectoris (Canadian Cardiovascular Society class) (p<0.001). There was a significant decrease in the left ventricular ejection fraction (LVEF) in Group B (81+/-7 vs 75+/-7%; p=0.002), but not in Group A (80+/-7 vs 79+/-7%; p=0.67). Thinning of the basal septum was more pronounced in Group B than in Group A (9.3+/-5.7 vs 6.6+/-3.4 mm; p=0.04).
  
  
  CONCLUSIONS
  A lower dose of ethanol injected into the target septal branch reduces both the size of necrosis and subsequent thinning of the basal septum, and preserves LVEF during long-term follow-up. Moreover, the low dose (1-2 ml) is as safe and as hemodynamically efficacious as higher doses.
authors.affiliation: Department of Cardiology, CardioVascular Center, University Hospital Motol, Praque, Czech Republic. veselka.josef@seznan.cz
authors.forename: Josef
authors.initials: J
authors.lastname: Veselka
authors.forename: Radka
authors.initials: R
authors.lastname: Duchonová
authors.forename: Jana
authors.initials: J
authors.lastname: Páleníckova
authors.forename: David
authors.initials: D
authors.lastname: Zemánek
authors.forename: Marie
authors.initials: M
authors.lastname: Tiserová
authors.forename: Katerina
authors.initials: K
authors.lastname: Linhartová
authors.forename: Pavel
authors.initials: P
authors.lastname: Cervinka
mesh_terms: D000328:Adult; D000368:Aged; D006328:Cardiac Catheterization; D002312:Cardiomyopathy, Hypertrophic / Q000628:therapy*; D002317:Cardiovascular Agents / Q000008:administration & dosage*; D000431:Ethanol / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D015552:Injections, Intralesional; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D016896:Treatment Outcome
chemical_list: D002317:Cardiovascular Agents; D000431:Ethanol