Pattern of thyroid autoimmunity in type 1 and type 2 diabetics.
OBJECTIVE
To determine the level of thyroid autoimmunity among clinically euthyroid patients of type 1 and type 2 diabetics and to correlate the levels with pattern of diabetes.


METHODS
Cross-sectional analytical study.


METHODS
Diabetic Clinic of Shaikh Zayed Hospital, Lahore from August 2004 to April 2005.


METHODS
Blood samples were collected from 163 subjects (51 of type 1, 61 of type 2 diabetics and 51 non- diabetic controls) and sera were separated. They were all clinically euthyroid and selected conveniently. Thyroid profile (FT4, TSH and anti-TPO) was assessed in the three groups and compared.


RESULTS
It was observed that at a cut off value of less than 100 units of anti-TPO level was normal, raised anti-TPO antibodies were found in 12% of normal control group, 61% in type 1 and 42.3% in type 2 diabetics. In type 1 diabetics, the TSH was higher in the younger age patients with progressive rise in anti-TPO antibodies level by age. The TSH, anti-TPO antibodies and BSF were significantly higher in type 1 diabetics than in the controls. In type 2 diabetics, TSH was moderately low but anti-TPO antibodies and BSF were higher than in the controls.


CONCLUSIONS
Thyroid autoimmune process seems to be correlated more with type 1 diabetic patients than with type 2 patients.
Yasmin
Tayyaba
T
Institute of Biochemistry and Biotechnology, University of the Punjab, Lahore.
Ghafoor
Farkhanda
F
Malik
Tahir
T
S
Ruhy Naz
RN
Khan
Aman Ullah
AU
D000328:Adult; D001323:Autoantibodies / Q000032:analysis; D003922:Diabetes Mellitus, Type 1 / Q000150:complications* / Q000276:immunology; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000276:immunology; D005260:Female; D006801:Humans; D007453:Iodide Peroxidase / Q000276:immunology; D008297:Male; D008875:Middle Aged; D013967:Thyroiditis, Autoimmune / Q000150:complications* / Q000276:immunology
D001323:Autoantibodies; D007453:Iodide Peroxidase