title: Monotherapy versus combination therapy.
abstract: The science of antibiotic therapy for infectious diseases continues to evolve. In many instances where empiric coverage is necessary, treatment with more than one agent is considered prudent. If an etiology is identified, antibiotics are modified based on culture and susceptibility data. Even when the organism is known, more than one antibiotic may be needed. Decisions about antibiotics should be made after assessments of pertinent clinical information, laboratory and microbiology information, ease of administration, patient compliance, potential adverse effects, cost, and available evidence supporting various treatment options. Clinicians also need to consider synergy and local resistance patterns in selecting therapeutic options. In this article, the authors outline monotherapy and combination therapy options for several common infectious diseases.
authors.affiliation: Division of Infectious Diseases, Department of Internal Medicine, St. John Hospital and Medical Center, 19251 Mack Avenue, Suite 340, Grosse Pointe Woods, MI 48236, USA. shilpa.patel@stjohn.org
authors.forename: Shilpa M
authors.initials: SM
authors.lastname: Patel
authors.forename: Louis D
authors.initials: LD
authors.lastname: Saravolatz
mesh_terms: D019980:Amoxicillin-Potassium Clavulanate Combination / Q000008:administration & dosage; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D001424:Bacterial Infections / Q000188:drug therapy*; D002481:Cellulitis / Q000188:drug therapy; D002511:Cephalosporins / Q000627:therapeutic use; D002939:Ciprofloxacin / Q000008:administration & dosage; D004238:Diverticulitis / Q000188:drug therapy; D004359:Drug Therapy, Combination; D004697:Endocarditis, Bacterial / Q000188:drug therapy; D013293:Enterococcus faecalis / Q000187:drug effects; D006801:Humans; D016920:Meningitis, Bacterial / Q000188:drug therapy; D009503:Neutropenia / Q000188:drug therapy; D010019:Osteomyelitis / Q000188:drug therapy; D011014:Pneumonia / Q000188:drug therapy; D013211:Staphylococcus aureus / Q000187:drug effects; D034363:Viridans Streptococci / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D002939:Ciprofloxacin; D019980:Amoxicillin-Potassium Clavulanate Combination