Intravenous CCK-8, but not GLP-1, suppresses ghrelin and stimulates PYY release in healthy men.
We have investigated the effects of exogenous CCK-8 and GLP-1, alone and in combination, on ghrelin and PYY secretion. Nine healthy males were studied on four occasions. Plasma ghrelin and PYY concentrations were measured during 150 min intravenous infusions of: (i) isotonic saline, (ii) CCK-8 at 1.8 pmol/kg/min, (iii) GLP-1 at 0.9 pmol/kg/min or (iv) CCK-8 and GLP-1 combined. CCK-8 markedly suppressed ghrelin and stimulated PYY when compared with control between t=0-120 min (P<0.001 for both). GLP-1 had no effect on ghrelin, but decreased PYY slightly at 120 min (P<0.05). During infusion of CCK-8+GLP-1, there was comparable suppression of ghrelin (P<0.001), but the stimulation of PYY was less (P<0.001), than that induced by CCK-8, between t=20-120 min. In conclusion, in healthy subjects, in the doses evaluated, exogenous CCK-8 suppresses ghrelin and stimulates PYY, and exogenous GLP-1 has no effect on ghrelin and attenuates the effect of CCK-8 on PYY.
Brennan
Ixchel M
IM
University of Adelaide Discipline of Medicine, Royal Adelaide Hospital, Adelaide, SA 5000, Australia.
Otto
Bärbel
B
Feltrin
Kate L
KL
Meyer
James H
JH
Horowitz
Michael
M
Feinle-Bisset
Christine
C
D000293:Adolescent; D000328:Adult; D054439:Ghrelin; D052216:Glucagon-Like Peptide 1 / Q000008:administration & dosage*; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D036361:Peptide Hormones / Q000097:blood* / Q000378:metabolism; D019894:Peptide YY / Q000097:blood* / Q000378:metabolism; D012844:Sincalide / Q000008:administration & dosage*
D054439:Ghrelin; D036361:Peptide Hormones; D019894:Peptide YY; D052216:Glucagon-Like Peptide 1; D012844:Sincalide