[Antimicrotubule agents can activate different apoptotic pathways].
The effect of agents (taxol, vincristine, and nocodazole) disturbing the microtubule network in MCF-7 human breast carcinoma cells has been examined. The aim of the study was to determine the subtypes of mitotic catastrophe and the dependence of cell death on the status of protein p53. Antimicrotubule agents can not only induce mitotic catastrophe, that is, cell death during mitosis and the death of micronucleated cells, but also activate apoptosis in interphase cells. We assume that the G1 checkpoint activation in this case occurs as a result of microtubule disruption. Apoptosis can be activated in a p53-independent manner in K-mitotic cells and after the complete disruption of the microtubule network.
Kisurina-Evgen'eva
O P
OP
Briantseva
S A
SA
Stil'
A A
AA
Onishchenko
G E
GE
D017209:Apoptosis; D045744:Cell Line, Tumor; D002467:Cell Nucleus / Q000378:metabolism; D006801:Humans; D008870:Microtubules / Q000187:drug effects; D008938:Mitosis; D015739:Nocodazole / Q000494:pharmacology*; D017239:Paclitaxel / Q000494:pharmacology*; D011123:Polyploidy; D021381:Protein Transport; D050257:Tubulin Modulators / Q000494:pharmacology*; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism; D014750:Vincristine / Q000494:pharmacology*
C495901:TP53 protein, human; D050257:Tubulin Modulators; D016159:Tumor Suppressor Protein p53; D014750:Vincristine; D017239:Paclitaxel; D015739:Nocodazole