[Stability of NT-ProBNP in patients with systolic heart failure].
Natriuretic peptides are extremely useful in the diagnosis and prognosis of patients with heart failure. However, it is not clear whether their values are stable. We carried out a prospective study of 30 consecutive ambulatory patients (mean age, 62.6 [12.2] years) with stable systolic heart failure, as determined by the 6-minute walk test, who were in New York Heart Association class II or III and who had a left ventricular ejection fraction <30% (mean ejection fraction, 24.2% [6.68%]). At baseline, the mean N-terminal pro-brain natriuretic peptide (NT-proBNP) level and the mean distance walked in 6 minutes were 2237.3 pg/mL and 348.26 m, respectively. At 3-month follow-up, the corresponding values were 2096.2 pg/mL and 372.05 m, respectively. No significant difference was observed in NT-proBNP level or in distance walked in 6 minutes between baseline and 3 months (P=.8). Overall, there was a good correlation (r=0.94; P< .001) between the plasma NT-proBNP level at baseline and at 3 months in patients with stable chronic heart failure due to systolic dysfunction in New York Heart Association class II or III.
Jiménez-Navarro
Manuel F
MF
Servicio de Cardiología, Hospital Clínico Universitario Virgen de la Victoria, Málaga, Spain. jimeneznavarro@secardiologia.es
Fernández-Moyano
María A
MA
Domínguez-Franco
Antonio
A
Gómez-Doblas
Juan J
JJ
Molero
Encarnación
E
Gómez-Hernández
Gemma
G
Morell
Miguel
M
De Teresa-Galván
Eduardo
E
D003627:Data Interpretation, Statistical; D005500:Follow-Up Studies; D006333:Heart Failure / Q000097:blood / Q000175:diagnosis*; D006801:Humans; D049449:Luminescence; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D011379:Prognosis; D011446:Prospective Studies; D013318:Stroke Volume; D013599:Systole; D013997:Time Factors; D016138:Walking
D020097:Natriuretic Peptide, Brain