Regularities in the E. coli promoters composition in connection with the DNA strands interaction and promoter activity.
The energy of interaction between DNA strands in promoters is of great functional importance. Visualization of the energy of DNA strands distribution in promoter sequences was achieved. The separation of promoters in groups by their energetic properties enables evaluation of the dependence of promoter strength on the energetic properties. The analysis of groups (clusters) of promoters distributed by the energy of DNA strands interaction in -55, -35, -10 and +6 sequences indicates their connection with the transcriptional activity.
Berezhnoy
Andrey Yu
AY
National Scientific Center, Kharkov Physical-Technical Institute, Kharkov 61108, Ukraine.
Shckorbatov
Yuriy G
YG
Hisanori
Kiryu
K
D004269:DNA, Bacterial / Q000235:genetics*; D004926:Escherichia coli / Q000235:genetics*; D011401:Promoter Regions, Genetic; D017422:Sequence Analysis, DNA
D004269:DNA, Bacterial