Exercise intensity influences cell injury in rat hippocampal slices exposed to oxygen and glucose deprivation.
We evaluated the effects of two levels of daily forced exercise intensity (moderate and high) in the treadmill over cell susceptibility to oxygen and glucose deprivation (OGD) in hippocampal slices from Wistar rats. Moderate exercise decreased lactate dehydrogenase (LDH) release after OGD, while a significant increase in LDH release was observed in the high intensity group submitted to OGD. Our data corroborate the hypothesis that higher training intensity exacerbates brain damage, while a moderate intensity reduces the injury caused by in vitro ischemia.
Scopel
Denise
D
Programa de Pós Graduação em Ciências Biológicas-Neurociências, RS, Brazil.
Fochesatto
Cíntia
C
Cimarosti
Helena
H
Rabbo
Maristela
M
Belló-Klein
Adriane
A
Salbego
Christianne
C
Netto
Carlos Alexandre
CA
Siqueira
Ionara Rodrigues
IR
D000818:Animals; D001681:Biological Assay; D020520:Brain Infarction / Q000503:physiopathology / Q000517:prevention & control* / Q000628:therapy; D002470:Cell Survival / Q000502:physiology; D004734:Energy Metabolism / Q000502:physiology; D005081:Exercise Therapy / Q000009:adverse effects / Q000379:methods* / Q000592:standards; D005947:Glucose / Q000378:metabolism; D020925:Hypoxia-Ischemia, Brain / Q000378:metabolism / Q000503:physiopathology / Q000517:prevention & control*; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008297:Male; D009410:Nerve Degeneration / Q000503:physiopathology / Q000517:prevention & control* / Q000628:therapy; D009924:Organ Culture Techniques; D010101:Oxygen Consumption / Q000502:physiology; D010805:Physical Conditioning, Animal / Q000009:adverse effects / Q000379:methods* / Q000592:standards; D051381:Rats; D015427:Reperfusion Injury / Q000503:physiopathology / Q000517:prevention & control* / Q000628:therapy; D013778:Tetrazolium Salts
D013778:Tetrazolium Salts; D007770:L-Lactate Dehydrogenase; D005947:Glucose