title: S-adenosylhomocysteine and polyunsaturated fatty acid metabolism in predementia syndromes and Alzheimer's disease.
abstract: Recent epidemiological evidence showed that dietary fatty acids, antioxidants, and micronutrients appear to have a role in cognitive decline, and may permit a beneficial effect on the risk of dementia and predementia syndromes. We discussed in the present paper the issue of the suggested protective role of polyunsaturated fatty acids (PUFA) on Alzheimer's disease, mild cognitive impairment, and other predementia syndromes, supported by the findings of the Italian Longitudinal Study on Aging (ILSA) and other population-based studies. In particular, we discussed the possible metabolic link of plasma S-adenosylhomocysteine concentrations with PUFA erythrocyte composition in explaining this suggested protective role of fatty acids against dementia and predementia syndromes.
authors.affiliation: Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, Bari, Italy. geriat.dot@geriatria.uniba.it
authors.forename: Francesco
authors.initials: F
authors.lastname: Panza
authors.forename: Cristiano
authors.initials: C
authors.lastname: Capurso
authors.forename: Alessia
authors.initials: A
authors.lastname: D'Introno
authors.forename: Anna M
authors.initials: AM
authors.lastname: Colacicco
authors.forename: Antonio
authors.initials: A
authors.lastname: Capurso
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Solfrizzi
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism*; D003704:Dementia / Q000378:metabolism*; D042241:Early Diagnosis; D005231:Fatty Acids, Unsaturated / Q000378:metabolism*; D006801:Humans; D012435:S-Adenosylhomocysteine / Q000378:metabolism*
chemical_list: D005231:Fatty Acids, Unsaturated; D012435:S-Adenosylhomocysteine