title: Isolated amyloidosis presenting with lumbosacral radiculoplexopathy: description of two cases and pathogenic review.
abstract: In this study, we present two cases of infiltrative, localized amyloidosis involving lumbosacral root and plexus, e.g., isolated amyloidomas. Rare and poorly understood amyloidomas may occur in both neurologic and non-neurologic tissues. The described cases emphasize potential for localized peripheral amyloidomas: (1) potential for associated lambda light chain lymphoplasmacytic lymphoma association; (2) e isolated amyloidosis without evidence for systemic plasma cell dyscrasia; (3) features suggestive of potential pathogenesis; and (4) discussion of treatment options including immunotherapy and resection. The limited literature and experience among other cases is described.
authors.affiliation: Department of Neurology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA.
authors.forename: Shafeeq S
authors.initials: SS
authors.lastname: Ladha
authors.forename: P James B
authors.initials: PJ
authors.lastname: Dyck
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Spinner
authors.forename: Domingo G
authors.initials: DG
authors.lastname: Perez
authors.forename: Steven R
authors.initials: SR
authors.lastname: Zeldenrust
authors.forename: Kimberly K
authors.initials: KK
authors.lastname: Amrami
authors.forename: Alan
authors.initials: A
authors.lastname: Solomon
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Klein
mesh_terms: D000368:Aged; D017772:Amyloid Neuropathies / Q000150:complications / Q000473:pathology* / Q000503:physiopathology*; D000686:Amyloidosis / Q000150:complications / Q000473:pathology* / Q000503:physiopathology*; D002420:Cauda Equina / Q000473:pathology; D003937:Diagnosis, Differential; D004594:Electrophysiology; D006801:Humans; D007147:Immunoglobulin Light Chains; D007150:Immunohistochemistry; D008160:Lumbosacral Plexus / Q000473:pathology*; D008161:Lumbosacral Region; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D008998:Monoclonal Gammopathy of Undetermined Significance / Q000150:complications; D011843:Radiculopathy / Q000209:etiology*; D012584:Sciatic Nerve / Q000473:pathology
chemical_list: D007147:Immunoglobulin Light Chains