Liver transplantation for fulminant hepatitis related to nevirapine therapy.
Drug-induced hepatotoxicity is an important cause of hepatocellular injury. Non-nucleoside retroviral transcriptase inhibitors are known to cause hepatotoxicity. We describe a detailed case of fulminant hepatitis induced by nevirapine (Viramune) and treated by liver transplantation.
Buyse
Sophie
S
Department of Hepatology and Hepatobiliar Surgery, Centre Hépato-Biliaire and INSERM U785, Hôpital Paul Brousse, 12 avenue Paul Vaillant Couturier, 94800, Villejuif, France.
Vibert
Eric
E
Sebagh
Mylène
M
Antonini
Teresa
T
Ichai
Philippe
P
Castaing
Denis
D
Samuel
Didier
D
Duclos-Vallée
Jean-Charles
JC
D000328:Adult; D019380:Anti-HIV Agents / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D015658:HIV Infections / Q000188:drug therapy; D015497:HIV-1; D006505:Hepatitis / Q000209:etiology / Q000473:pathology / Q000601:surgery*; D006801:Humans; D017114:Liver Failure, Acute / Q000139:chemically induced / Q000473:pathology / Q000601:surgery*; D016031:Liver Transplantation; D019829:Nevirapine / Q000009:adverse effects* / Q000627:therapeutic use; D016896:Treatment Outcome
D019380:Anti-HIV Agents; D019829:Nevirapine