Disease pathology: wasting energy fighting infection.
Drosophila melanogaster infected with Mycobacterium marinum suffer metabolic wasting similar to that seen in humans suffering from tuberculosis. This wasting is linked to insulin signaling and hastens host death.
Lazzaro
Brian P
BP
Department of Entomology, Field of Genetics and Development, Cornell University, Ithaca, New York 15843, USA. BL89@cornell.edu
Galac
Madeline R
MR
D000818:Animals; D004331:Drosophila melanogaster / Q000382:microbiology; D004734:Energy Metabolism / Q000276:immunology / Q000502:physiology*; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D019910:Mycobacterium marinum; D015398:Signal Transduction / Q000502:physiology*; D014376:Tuberculosis / Q000276:immunology / Q000503:physiopathology*; D015431:Weight Loss
D007328:Insulin