title: Environmental impacts on children's health in Southeast Asia: genotoxic compounds in urban air.
abstract: Air pollution is a serious problem in many countries in Southeast Asia, particularly in major metropolises with high levels of traffic congestion generating significant amounts of genotoxic substances. The contribution of such environmental exposure to children's illnesses, such as respiratory diseases and cancer, is a public health concern. Inner-city children may have higher levels of exposure to genotoxic substances in the air than those living in rural areas. This study was conducted in Bangkok, where ambient levels of polycyclic aromatic hydrocarbons (PAHs) and benzene are relatively high. Bangkok school children were exposed to total PAHs at about sixfold higher levels than those in rural areas, with levels of urinary 1-hydroxypyrene (1-OHP) also being significantly higher. PAH-DNA adduct levels in lymphocytes were fivefold higher in Bangkok children. Benzene exposure in Bangkok school children was more than twofold higher than the levels measured in children from the rural areas. This is in agreement with the biomarkers of internal dose, that is, blood benzene and urinary trans, trans-muconic acid (t,t-MA) levels. The potential health risks from exposure to PAHs and benzene were assessed through the use of DNA damage and DNA repair capacity as markers of early biological effect. DNA strand breaks were significantly higher in Bangkok school children, while DNA repair capacity was significantly lower. It appears that children in major cities in developing countries may have an increased health risk for the development of certain diseases, such as cancer due to exposure to genotoxic substances in their environment.
authors.affiliation: Laboratory of Environmental Toxicology, Chulabhorn Research Institute, Donmuang, Bangkok 10210, Thailand. mathuros@tubtim.cri.or.th
authors.forename: Mathuros
authors.initials: M
authors.lastname: Ruchirawat
authors.forename: Panida
authors.initials: P
authors.lastname: Navasumrit
authors.forename: Daam
authors.initials: D
authors.lastname: Settachan
authors.forename: Herman
authors.initials: H
authors.lastname: Autrup
mesh_terms: D000393:Air Pollutants / Q000633:toxicity*; D002648:Child; D002669:Child Welfare; D004781:Environmental Exposure; D006801:Humans; D009153:Mutagens / Q000633:toxicity*; D018570:Risk Assessment; D013785:Thailand; D014504:Urban Health
chemical_list: D000393:Air Pollutants; D009153:Mutagens