title: Evaluation of in-stent restenosis in proximal coronary arteries with multidetector computed tomography (MDCT).
abstract: The purpose of this study was to assess the ability of 16-slice computed tomography (CT) to detect in-stent restenosis of proximal coronary arteries. From November 2002 to April 2004, 134 consecutive patients with proximal stents (3.25 +/- 0.47 mm) were prospectively studied. Multidetector CT (MDCT) was performed 24 h (baseline) and 6 months after angioplasty and analysed by two radiologists blinded to the results of the coronary angiography. Sensitivity, specificity, positive and negative predictive values for in-stent restenosis were compared with conventional quantitative coronary angiography (QCA). Stenosis with a diameter >or=50% was considered diagnostic of in-stent restenosis. The CT analysis was performed in 131 and 114 patients at baseline and 6 months, respectively. The in-stent lumen was evaluable in 111 (121 stents) and 99 patients (108 stents) at baseline and 6 months, respectively. The prevalence of in-stent restenosis was 22.5%. Restenoses were correctly identified in 91.7 and 87.5% by the two radiologists. The sensitivity, specificity, positive and negative predictive values for the assessment of significant in-stent restenosis were 92, 67, 43, 97% and 87, 66, 41, 95% for the radiologists, respectively. MDCT is a potential non-invasive technique for the screening of in-stent restenosis of proximal coronary arteries that needs further improvements.
authors.affiliation: Department of Radiology, CHU Rangueil, 1 avenue Jean-Poulhes TSA 50032, 31059 Toulouse Cedex 9, France. Chabbert.v@chu-toulouse.fr
authors.forename: V
authors.initials: V
authors.lastname: Chabbert
authors.forename: D
authors.initials: D
authors.lastname: Carrie
authors.forename: M
authors.initials: M
authors.lastname: Bennaceur
authors.forename: E
authors.initials: E
authors.lastname: Maupas
authors.forename: V
authors.initials: V
authors.lastname: Lauwers
authors.forename: M
authors.initials: M
authors.lastname: Mhem
authors.forename: T
authors.initials: T
authors.lastname: Lhermusier
authors.forename: M
authors.initials: M
authors.lastname: Elbaz
authors.forename: F
authors.initials: F
authors.lastname: Joffre
authors.forename: H
authors.initials: H
authors.lastname: Rousseau
authors.forename: J
authors.initials: J
authors.lastname: Puel
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017023:Coronary Angiography; D023903:Coronary Restenosis / Q000000981:diagnostic imaging*; D023921:Coronary Stenosis / Q000000981:diagnostic imaging / Q000628:therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011446:Prospective Studies; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D015607:Stents; D014057:Tomography, X-Ray Computed / Q000379:methods*