title: CD10-MUM1+ follicular lymphoma lacks BCL2 gene translocation and shows characteristic biologic and clinical features.
abstract: CD10 and MUM1 are representative B cell differentiation markers. Follicular lymphoma (FL) is usually positive for CD10 and negative for MUM1. In this study, however, we compared 22 FLs with peculiar phenotype CD10-MUM1+ with 119 typical CD10+MUM1- FLs. All CD10-MUM1+ FL patients exhibited follicular structure with follicular dendritic meshwork, and a high rate of somatic hypermutation and ongoing mutation, similar to typical FL. However, CD10-MUM1+ FLs were encountered frequently in the elderly compared with CD10+MUM1- typical FLs (67.0 versus 58.7 years, P < .01), showed high grade (grade 3A or 3B) morphology (91% versus 17%, P < .001), diffuse proliferation (59% vs 19%, P < .001), and lacked BCL2/IGH translocation (5% versus 92.5%, P < .001), which is the most characteristic aberration in FL, and 88% showed BCL6 gene abnormalities (translocation or amplification). Our results indicate that CD10-MUM1+ FL is different from typical FL with respect to biologic and clinical features.
authors.affiliation: Department of Pathology, State Key Laboratory of Cancer Biology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shannxi, People's Republic of China. karube1975@yahoo.co.jp
authors.forename: Kennosuke
authors.initials: K
authors.lastname: Karube
authors.forename: Ying
authors.initials: Y
authors.lastname: Guo
authors.forename: Junji
authors.initials: J
authors.lastname: Suzumiya
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Sugita
authors.forename: Yuko
authors.initials: Y
authors.lastname: Nomura
authors.forename: Kohei
authors.initials: K
authors.lastname: Yamamoto
authors.forename: Kei
authors.initials: K
authors.lastname: Shimizu
authors.forename: Shirou
authors.initials: S
authors.lastname: Yoshida
authors.forename: Hideki
authors.initials: H
authors.lastname: Komatani
authors.forename: Morishige
authors.initials: M
authors.lastname: Takeshita
authors.forename: Masahiro
authors.initials: M
authors.lastname: Kikuchi
authors.forename: Naoya
authors.initials: N
authors.lastname: Nakamura
authors.forename: Osamu
authors.initials: O
authors.lastname: Takasu
authors.forename: Fumiko
authors.initials: F
authors.lastname: Arakawa
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Tagawa
authors.forename: Masao
authors.initials: M
authors.lastname: Seto
authors.forename: Koichi
authors.initials: K
authors.lastname: Ohshima
mesh_terms: D000368:Aged; D005260:Female; D019254:Genes, bcl-2; D006801:Humans; D050835:Interferon Regulatory Factors / Q000378:metabolism*; D008224:Lymphoma, Follicular / Q000235:genetics* / Q000276:immunology* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009154:Mutation; D015260:Neprilysin / Q000378:metabolism*; D010641:Phenotype; D027041:Somatic Hypermutation, Immunoglobulin; D014178:Translocation, Genetic; D000099218:Interferon Regulatory Factor-4
chemical_list: D050835:Interferon Regulatory Factors; D015260:Neprilysin; D000099218:Interferon Regulatory Factor-4