The gene for human IL-21 and genetic susceptibility to type 1 diabetes in the Japanese.
Type 1 diabetes is under polygenic control both in humans and the NOD mouse. Recently a possible role of IL-21 in the pathogenesis of type 1 diabetes was demonstrated in the NOD mouse. Furthermore, the murine IL-21 gene is mapped to the Idd3 interval, making the human IL-21 gene (IL21) a functional as well as positional candidate for susceptibility. We therefore screened sequence variants of IL21 and studied the association with type 1 diabetes. Preliminary data showed no association of IL21 polymorphisms with the disease, suggesting that IL21 plays little role in susceptibility to type 1 diabetes in Japanese.
Asano
Katsuaki
K
Department of Endocrinology, Diabetes and Metabolism, Kinki University School of Medicine, 377-2 Ohno-higashi, Sayama, Osaka 589-8511, Japan.
Ikegami
Hiroshi
H
Fujisawa
Tomomi
T
Kawabata
Yumiko
Y
Noso
Shinsuke
S
Hiromine
Yoshihisa
Y
Ogihara
Toshio
T
D000483:Alleles; D016022:Case-Control Studies; D030541:Databases, Genetic; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics*; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D006801:Humans; D007378:Interleukins / Q000235:genetics*; D007564:Japan / Q000453:epidemiology; D020641:Polymorphism, Single Nucleotide; D017422:Sequence Analysis, DNA; D000098546:Interleukin-21
D007378:Interleukins; D000098546:Interleukin-21