From insect ovaries to sheep red blood cells: a tale of two hormones.
This printed version of the Wigglesworth Lecture reviews the evidence that juvenile hormone (JH) acts on the follicular epithelium of the ovary through a membrane receptor to control access of yolk proteins to the oocyte surface. The thyroid hormones mimic this action through the same receptor. Conversely, both JH III and 3,5,3' triiodothyronine (T3) increase the activity of Ca ATPase in isolated erythrocyte membrane preparations from sheep, apparently through the same membrane receptor. These effects are mimicked by exposure of the respective tissues to CO(2). These findings suggest that the hormones arose as biotic signals, originally using existing CO(2) receptors.
Davey
Kenneth
K
York University, Biology, 4700 Keele Street, Toronto, Ont., Canada M3J 1P3. davey@yorku.ca
D000818:Animals; D004912:Erythrocytes / Q000378:metabolism*; D005260:Female; D007313:Insecta / Q000378:metabolism*; D007605:Juvenile Hormones / Q000378:metabolism*; D010053:Ovary / Q000378:metabolism*; D012756:Sheep / Q000378:metabolism*; D013963:Thyroid Hormones / Q000378:metabolism*
D007605:Juvenile Hormones; D013963:Thyroid Hormones