Acylphloroglucinol derivatives from Hypericum prolificum.
Three new acylphloroglucinol derivatives have been isolated from the hexane extract of the aerial parts of Hypericum prolificum L.: prolificin A (1), prolifenone A (2), and prolifenone B (3). The structures were elucidated on the basis of extensive 2D NMR and MS data. All three compounds were evaluated for in vitro cell proliferation inhibitory activity against human breast (MCF-7), lung (NCI-H460), CNS (SF-268), stomach (AGS), and colon (HCT-116) tumor cell lines. Prolificin A showed growth inhibition of all cell lines with IC50 values ranging from 23 to 36 microM. Prolifenones A and B were inactive at the concentrations tested.
Henry
Geneive E
GE
Department of Chemistry, Susquehanna University, 514 University Avenue, Selinsgrove, Pennsylvania 17870, USA. henry@susqu.edu
Raithore
Smita
S
Zhang
Yanjun
Y
Jayaprakasam
Bolleddula
B
Nair
Muraleedharan G
MG
Heber
David
D
Seeram
Navindra P
NP
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020902:Hypericum / Q000737:chemistry*; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D010414:Pennsylvania; D010696:Phloroglucinol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*
D000972:Antineoplastic Agents, Phytogenic; C516760:prolifenone A; C516761:prolifenone B; C516759:prolificin A; D010696:Phloroglucinol