The effect of an experimental chlorate product on Salmonella recovery of turkeys when administered prior to feed and water withdrawal.
Previously, an experimental chlorate product (ECP) has been observed to reduce Escherichia coli and Salmonella infections in swine, cattle, and broilers. The following studies were performed to investigate the effects of different concentrations and durations of administering ECP on crop and ceca Salmonella typhimurium (ST) colonization of turkeys. In 2 separate trials, each conducted with 2 replicates, 15-wk-old turkey toms were challenged with 10(7) to 10(9) cfu of ST. In Experiment 1, toms were administered 0, 0.5, 1.0, 2.0, or 4.0x of ECP (a 1.0x concentration is equivalent to a 15 mM chlorate ion concentration) in the drinking water for 38 h. In Experiment 2, toms were administered a 2x concentration of ECP in the drinking water for 0, 14, 26, or 38 h prior to water withdrawal. All treatments were followed by a 10-h water withdrawal and an 8-h feed withdrawal prior to organ sampling. In Experiment 1, turkeys provided ECP had significantly (P < 0.05) lower populations and incidences of crop (>1.4 log reduction) and ceca (>0.6 log reduction) ST as compared with control birds (2.1 and 0.94 log ST average for all trials, respectively), with little or no additional benefit from administration of higher ECP concentrations. In Experiment 2, toms provided ECP had lower populations of crop (>2.2 log reduction) and ceca (>1.5 log reduction) ST when compared with controls (3.1 and 1.8 log ST, respectively). Again, there appeared to be little benefit in longer administration intervals on quantitative reduction of ST. These experiments suggest that the ECP significantly reduces Salmonella colonization in commercial turkeys when administered prior to feed and water withdrawal.
Moore
R W
RW
Southern Plains Agricultural Research Center, Food and Feed Safety Research Unit, United States Department of Agriculture, Agricultural Research Service, College Station, TX 77845, USA. rmoore@seprl.usda.gov
Byrd
J A
JA
Knape
K D
KD
Anderson
R C
RC
Callaway
T R
TR
Edrington
T
T
Kubena
L F
LF
Nisbet
D J
DJ
D000821:Animal Feed; D000818:Animals; D002432:Cecum / Q000382:microbiology*; D002704:Chlorates / Q000494:pharmacology*; D003426:Crop, Avian / Q000382:microbiology*; D019587:Dietary Supplements; D004305:Dose-Response Relationship, Drug; D005508:Food Deprivation; D008297:Male; D012481:Salmonella Infections, Animal / Q000188:drug therapy*; D012486:Salmonella typhimurium / Q000187:drug effects*; D013997:Time Factors; D014422:Turkeys / Q000382:microbiology*; D014868:Water Deprivation
D002704:Chlorates