title: Pterocarpus santalinus: an In Vitro study on its anti-Helicobacter pylori effect.
abstract: The anti-H. pylori activity of Pterocarpus santalinus (PS), a traditional herb, has been assessed and compared with that of bismuth subcitrate, through in vitro studies employing rat gastric epithelial cell cultures and H. pylori isolates from gastric mucosal biopsy patients. The MIC of PS was found to be 20 microg/mL. H. pylori was co-cultivated with rat gastric epithelial cells in the presence/absence of PS at its MIC. A reduction in the activity of urease, a normal appearance of the epithelial cells on electron microscopic examination, a decrease in lipid peroxidation and lactate dehydrogenase suggests the possible anti-H. pylori activity of PS.
authors.affiliation: Department of Biochemistry, University of Madras, Guindy Campus, Chennai 600 025, India. shoba_narayan@rediffmail.com
authors.forename: Shoba
authors.initials: S
authors.lastname: Narayan
authors.forename: Mani
authors.initials: M
authors.lastname: Veeraraghavan
authors.forename: C S Shyamala
authors.initials: CS
authors.lastname: Devi
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002478:Cells, Cultured; D004847:Epithelial Cells / Q000187:drug effects / Q000382:microbiology / Q000648:ultrastructure; D005753:Gastric Mucosa / Q000187:drug effects / Q000382:microbiology / Q000648:ultrastructure; D016480:Helicobacter pylori / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D046529:Microscopy, Electron, Transmission; D008871:Microvilli / Q000648:ultrastructure; D010936:Plant Extracts / Q000494:pharmacology*; D035721:Pterocarpus / Q000737:chemistry*; D051381:Rats
chemical_list: D000900:Anti-Bacterial Agents; D010936:Plant Extracts; C519377:Pterocarpus santalinus extract