title: Spatial genome organization in the formation of chromosomal translocations.
abstract: Chromosomal translocations and genomic instability are universal hallmarks of tumor cells. While the molecular mechanisms leading to the formation of translocations are rapidly being elucidated, a cell biological understanding of how chromosomes undergo translocations in the context of the cell nucleus in vivo is largely lacking. The recent realization that genomes are non-randomly arranged within the nuclear space has profound consequences for mechanisms of chromosome translocations. We review here the emerging principles of spatial genome organization and discuss the implications of non-random spatial genome organization for the genesis and specificity of cancerous chromosomal translocations.
authors.affiliation: National Cancer Institute, NIH, Bethesda, MD 20892, United States. meaburnk@mail.nih.gov
authors.forename: Karen J
authors.initials: KJ
authors.lastname: Meaburn
authors.forename: Tom
authors.initials: T
authors.lastname: Misteli
authors.forename: Evi
authors.initials: E
authors.lastname: Soutoglou
mesh_terms: D002467:Cell Nucleus / Q000378:metabolism; D016678:Genome; D015894:Genome, Human; D042822:Genomic Instability; D006801:Humans; D007399:Interphase; D008954:Models, Biological; D008957:Models, Genetic; D009369:Neoplasms / Q000235:genetics; D012441:Saccharomyces cerevisiae / Q000235:genetics; D014178:Translocation, Genetic