title: Effect of direct hemoperfusion with a polymyxin B immobilized fiber column on high mobility group box-1 (HMGB-1) in severe septic shock: report of a case.
abstract: Because of the many difficult aspects in the treatment of septic shock and poor outcome of this condition, establishing the most appropriate therapeutic strategy is problematic. Recently, high mobility group box-1 (HMGB-1) has been shown to activate inflammatory responses and to be a late mediator in endotoxemia and sepsis. Therefore, we considered that it might be worthwhile to investigate the therapeutic potential of HMGB-1 blockade in cases of septic shock.Herein, we describe the case of a patient with septic shock with hepatic portal venous gas caused by intestinal obstruction. Hepatic portal venous gas is a rare condition associated with significant radiographic findings and a fatal outcome. Our patient, however, recovered from severe septic shock and was saved by the use of direct hemoperfusion with a polymyxin B immobilized fiber column (DHP-PMX). This treatment resulted in a decrease in the serum levels of endotoxin, interleukin-6 (IL-6), and HMGB-1.
authors.affiliation: Department of Emergency and Critical Care Medicine, Chiba Hokisou Hospital, Nippon Medical School, Inba-Gun, Chiba, Japan.
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Sakamoto
authors.forename: Kunihiro
authors.initials: K
authors.lastname: Mashiko
authors.forename: Hisashi
authors.initials: H
authors.lastname: Matsumoto
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Hara
authors.forename: Noriyosho
authors.initials: N
authors.lastname: Kutsukata
authors.forename: Kenkichi
authors.initials: K
authors.lastname: Takei
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Ueno
authors.forename: Yoshiteru
authors.initials: Y
authors.lastname: Tomita
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Yamamoto
mesh_terms: D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents; D004731:Endotoxins / Q000097:blood; D005260:Female; D024243:HMGB1 Protein / Q000037:antagonists & inhibitors* / Q000097:blood; D006464:Hemoperfusion / Q000379:methods*; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D007415:Intestinal Obstruction / Q000150:complications / Q000000981:diagnostic imaging / Q000276:immunology; D011112:Polymyxin B; D012720:Severity of Illness Index; D012772:Shock, Septic / Q000209:etiology / Q000276:immunology / Q000628:therapy*; D014057:Tomography, X-Ray Computed
chemical_list: D000900:Anti-Bacterial Agents; D004731:Endotoxins; D024243:HMGB1 Protein; D015850:Interleukin-6; D011112:Polymyxin B