Avian influenza A (H5N1) infection in eastern Turkey in 2006.
BACKGROUND
An outbreak of highly pathogenic avian influenza A (H5N1) that had previously been detected throughout Asia, with major economic and health repercussions, extended to eastern Turkey in late December 2005 and early January 2006.


METHODS
We documented the epidemiologic, clinical, and radiologic features of all cases of confirmed H5N1 virus infection in patients who were admitted to Yuzuncu Yil University Hospital in Van, Turkey, between December 31, 2005, and January 10, 2006.


RESULTS
H5N1 virus infection was diagnosed in eight patients. The patients were 5 to 15 years of age, and all eight had a history of close contact with diseased or dead chickens. The mean (+/-SD) time between exposure and the onset of illness was 5.0+/-1.3 days. All the patients had fever, and seven had clinical and radiologic evidence of pneumonia at presentation; four patients died. Results of enzyme-linked immunosorbent assay and rapid influenza tests were negative in all patients, and the diagnosis was made by means of a polymerase-chain-reaction assay.


CONCLUSIONS
H5N1, which causes a spectrum of illnesses in humans, including severe and fatal respiratory disease, can be difficult to diagnose.
Oner
Ahmet Faik
AF
Faculty of Medicine, Yuzuncu Yil University, Van, Turkey. afo59@yahoo.com
Bay
Ali
A
Arslan
Sukru
S
Akdeniz
Hayrettin
H
Sahin
Huseyin Avni
HA
Cesur
Yasar
Y
Epcacan
Serdar
S
Yilmaz
Neziha
N
Deger
Ibrahim
I
Kizilyildiz
Baran
B
Karsen
Hasan
H
Ceyhan
Mehmet
M
D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000998:Antiviral Agents / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D004196:Disease Outbreaks; D005260:Female; D006801:Humans; D053124:Influenza A Virus, H5N1 Subtype / Q000235:genetics / Q000302:isolation & purification*; D007251:Influenza, Human / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy; D008297:Male; D053139:Oseltamivir / Q000627:therapeutic use; D016133:Polymerase Chain Reaction; D012121:Respiration, Artificial; D014421:Turkey / Q000453:epidemiology
D000900:Anti-Bacterial Agents; D000998:Antiviral Agents; D053139:Oseltamivir