title: Computational representation of Alzheimer's disease evolution applied to a cooking activity.
abstract: This article presents a computational model and a simulation of the decrease of activities of daily living performances due to Alzheimer's disease. The disease evolution is simulated thanks to the cognitive architecture ACT-R. Activities are represented according to the retrieval of semantic units in declarative memory and the trigger of rules in procedural memory. The simulation of Alzheimer's disease decrease is simulated thanks to the variation of subsymbolic parameters. The model is applied to a cooking activity. Simulation of 100 hundred subjects shows results similar to those realised in a standardized assessment with human subjects.
authors.affiliation: TIMC-IMAG UMR CNRS 5525 Laboratory, Grenoble, France. Audrey.Serna@imag.fr
authors.forename: Audrey
authors.initials: A
authors.lastname: Serna
authors.forename: Vincent
authors.initials: V
authors.lastname: Rialle
authors.forename: Hélène
authors.initials: H
authors.lastname: Pigot
mesh_terms: D000544:Alzheimer Disease / Q000503:physiopathology*; D003296:Cooking; D018450:Disease Progression; D006801:Humans; D015233:Models, Statistical; D013647:Task Performance and Analysis