title: 4-Hydroxyproline metabolism and glyoxylate production: A target for substrate depletion in primary hyperoxaluria?
abstract: The primary hyperoxalurias are diseases of overproduction of oxalate. The immediate precursor of oxalate is glyoxylate. Metabolism of hydroxyproline, derived from collagen turnover or the diet, appears to be a major source of glyoxylate, and a potential target for a therapeutic strategy of substrate depletion.
authors.affiliation: Department of Pediatrics, University of British Columbia, Vancouver, Canada. marioncm@interchange.ubc.ca
authors.forename: M B
authors.initials: MB
authors.lastname: Coulter-Mackie
mesh_terms: D000328:Adult; D005260:Female; D006038:Glyoxylates / Q000378:metabolism*; D006801:Humans; D006909:Hydroxyproline / Q000378:metabolism*; D006960:Hyperoxaluria, Primary / Q000378:metabolism / Q000628:therapy*; D008297:Male; D010070:Oxalates / Q000378:metabolism
chemical_list: D006038:Glyoxylates; D010070:Oxalates; C031150:glyoxylic acid; D006909:Hydroxyproline