An analysis of surgical complications, morbidity, and cost calculation in patients undergoing multimodal treatment for operable oropharyngeal carcinoma.
OBJECTIVE
Tumor control and survival are considered the most important measures of treatment efficacy for patients with primary oropharyngeal squamous cell carcinoma. Furthermore, multimodal treatment protocols should be judged by their complication rates, morbidity, and therapy costs.


METHODS
The results of a combined approach of primary surgery and neck dissection with postoperative radio(chemo)therapy were analyzed in retrospective chart review.


METHODS
Two hundred eleven patients' records were analyzed for surgical complications, therapeutic morbidity, and treatment costs.


RESULTS
The rate of postoperative hemorrhage was 4.7%. We observed no fatal complications. Ten percent of our patients required nutrition through percutaneous endoscopic gastrostomy (PEG). Twelve percent of all patients required long-term tracheostomy. The rates of PEG and tracheostomy were significantly higher in patients operated by the transcervical approach. The costs for the combined approach ranged from 10,587 euros (13,377 dollars) to 24,531 euros (30,996 dollars).


CONCLUSIONS
The presented multimodal approach provides a low rate of surgical complications and a tolerable morbidity. Considering the excellent oncologic results, this extensive and more cost-intensive multimodal approach is justified for patients with oropharyngeal cancer.
Preuss
Simon F
SF
Department of Otorhinolaryngology, Head and Neck Surgery, School of Medicine, University of Cologne, Cologne, Germany. simon.preuss@uni-koeln.de
Quante
Gero
G
Semrau
Robert
R
Mueller
Rolf-Peter
RP
Klussmann
Jens Peter
JP
Guntinas-Lichius
Orlando
O
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000191:economics / Q000628:therapy*; D003131:Combined Modality Therapy / Q000009:adverse effects / Q000191:economics; D004180:Direct Service Costs; D005260:Female; D005774:Gastrostomy / Q000706:statistics & numerical data; D006801:Humans; D008297:Male; D008875:Middle Aged; D037981:Neck Dissection / Q000191:economics; D009959:Oropharyngeal Neoplasms / Q000191:economics / Q000628:therapy*; D011183:Postoperative Complications / Q000453:epidemiology; D012189:Retrospective Studies; D014139:Tracheostomy / Q000706:statistics & numerical data; D016896:Treatment Outcome