GABAA receptors in central nervous system disease: anxiety, epilepsy, and insomnia.
Brain function is based on an exquisite balance between excitatory and inhibitory neurotransmission. GABAergic neurons provide the major inhibitory control. By controlling spike timing and sculpting neuronal rhythms they play a key role in regulating behavior. GABAergic neurons are highly diverse and operate with a corresponding diversity of GABAA receptor subtypes. In this article, the contribution of GABAA receptor deficits to central nervous system disorders, in particular anxiety disorders, epilepsy, schizophrenia and insomnia, is reviewed.
Möhler
Hanns
H
Institute of Pharmacology, University of Zurich, Zurich, Switzerland. mohler@pharma.unizh.ch
D001008:Anxiety Disorders / Q000209:etiology / Q000235:genetics; D002493:Central Nervous System Diseases / Q000209:etiology* / Q000235:genetics; D004827:Epilepsy / Q000209:etiology / Q000235:genetics; D006801:Humans; D011963:Receptors, GABA-A / Q000235:genetics* / Q000502:physiology*; D012559:Schizophrenia / Q000209:etiology / Q000235:genetics; D007319:Sleep Initiation and Maintenance Disorders / Q000209:etiology / Q000235:genetics
D011963:Receptors, GABA-A