title: Donor cell-derived acute myeloblastic leukemia after allogeneic peripheral blood hematopoietic stem cell transplantation for juvenile myelomonocytic leukemia.
abstract: Despite its rarity, donor cell leukemia (DCL) is a most intriguing entity. We report here the case of a 5 year-old girl with juvenile myelomonocytic leukemia and normal female karyotype who developed acute myeloblastic leukemia with a karyotype of 46, X, t(X; 7) (p21; p11.2), der(7) t(3; 7) (q13.3; q22) 5 months after peripheral blood hematopoietic stem cell transplantation from her HLA-matched sister. We performed the analysis of short tandem repeat sequence markers to DNA obtained from donor peripheral blood, patient's peripheral blood including leukemic blasts and patient's hair root. This analysis showed that the leukemic blood DNA matched the donor blood DNA and not the patient's DNA, thus confirming DCL. To our knowledge, this is the first case of DCL after peripheral blood SCT for juvenile myelomonocytic leukemia.
authors.affiliation: Department of Pediatrics, Akdeniz University, Antalya, Turkey.
authors.forename: Zafer
authors.initials: Z
authors.lastname: Cetin
authors.forename: Gulsun
authors.initials: G
authors.lastname: Tezcan
authors.forename: Sibel Berker
authors.initials: SB
authors.lastname: Karauzum
authors.forename: Alphan
authors.initials: A
authors.lastname: Kupesiz
authors.forename: Ayse Esra
authors.initials: AE
authors.lastname: Manguoglu
authors.forename: Akif
authors.initials: A
authors.lastname: Yesilipek
authors.forename: Guven
authors.initials: G
authors.lastname: Luleci
authors.forename: Volkan
authors.initials: V
authors.lastname: Hazar
mesh_terms: D001782:Blood Donors; D002675:Child, Preschool; D002869:Chromosome Aberrations; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000209:etiology*; D015477:Leukemia, Myelomonocytic, Chronic / Q000150:complications / Q000235:genetics / Q000628:therapy*; D016609:Neoplasms, Second Primary; D036102:Peripheral Blood Stem Cell Transplantation / Q000009:adverse effects*; D018183:Transplantation Chimera / Q000235:genetics; D014184:Transplantation, Homologous