The protective effect of melatonin against fumonisin-induced renal damage in rats.
The present study was designed to investigate the potential protective effect of melatonin against the renal toxicity of fumonisin in female rats. Six groups of animals were used in this study. The first group served as control. The second group was given melatonin only at a dose level of 10 mg/kg. The third group was fed ration contaminated with fumonisin (100 mg/kg diet). The fourth group was fed ration contaminated with fumonisin (200 mg/kg diet). The fifth group was given daily interperitoneal injection (IP) 10 mg/kg melatonin and fed ration contaminated with fumonisin (100 mg/kg diet). The sixth group was given daily interperitoneal injection of 10 mg/kg melatonin and fed ration contaminated with fumonisin (200 mg/kg diet). The rats were treated for 1 month. Histopathological and histochemical changes in the kidney were investigated. In addition, DNA ploidy was measured in the kidney. Fumonisin administration (100 or 200 mg/Kg diet) to unpretreated control rats caused extensive renal damage as evaluated by histopathology, histochemistry, and/or DNA ploidy measurement. No apparent changes following administration of melatonin. Melatonin coadministration to the fumonisin-administered rats reduced kidney damage and the tissues appeared more or less like the normal. The present study indicates that melatonin has a protective effect in fumonisin-induced renal damage.
Morsy
Fatma A
FA
Pathology Department, Medical Division Research, National Research Center, Dokki, Egypt.
Badawy
Manal A
MA
Farrag
Abdel Razik H
AR
D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D004247:DNA / Q000032:analysis; D005260:Female; D037341:Fumonisins / Q000633:toxicity*; D007668:Kidney / Q000187:drug effects* / Q000473:pathology; D007674:Kidney Diseases / Q000139:chemically induced / Q000235:genetics / Q000473:pathology / Q000517:prevention & control*; D008550:Melatonin / Q000494:pharmacology*; D011003:Ploidies; D020011:Protective Agents / Q000494:pharmacology*; D051381:Rats
D037341:Fumonisins; D020011:Protective Agents; D004247:DNA; D000469:Alkaline Phosphatase; D008550:Melatonin