RNAIII-inhibiting-peptide-loaded polymethylmethacrylate prevents in vivo Staphylococcus aureus biofilm formation.
Staphylococci, common orthopedic pathogens, form antibiotic-resistant biofilms. Polymethylmethacrylate (PMMA) beads loaded with the quorum-sensing inhibitor RNAIII-inhibiting peptide (RIP) were implanted in rats and shown to prevent methicillin-resistant Staphylococcus aureus infection. RIP release was bimodal, typical of previously-tested antibiotics. These results suggest that RIP-PMMA warrants further evaluation for management of orthopedic infections caused by staphylococci.
Anguita-Alonso
Paloma
P
Division of Infectious Diseases, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.
Giacometti
Andrea
A
Cirioni
Oscar
O
Ghiselli
Roberto
R
Orlando
Fiorenza
F
Saba
Vittorio
V
Scalise
Giorgio
G
Sevo
Milica
M
Tuzova
Marina
M
Patel
Robin
R
Balaban
Naomi
N
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D018441:Biofilms / Q000187:drug effects* / Q000254:growth & development; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004337:Drug Carriers / Q000737:chemistry*; D008297:Male; D008863:Microspheres; D009842:Oligopeptides / Q000494:pharmacology* / Q000627:therapeutic use; D011109:Polymethacrylic Acids / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D013203:Staphylococcal Infections / Q000188:drug therapy / Q000517:prevention & control; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000502:physiology*; D014640:Vancomycin / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D004337:Drug Carriers; D009842:Oligopeptides; D011109:Polymethacrylic Acids; C111711:RNAIII inhibiting peptide; C030613:polymethacrylic acid; D014640:Vancomycin