title: Study of nasopharyngeal bacterial flora. Second report. Variations in nasopharyngeal bacterial flora in children aged 6 years or younger when administered antimicrobial agents. Part 2.
abstract: This report focuses on changes in the nasopharyngeal bacterial flora before and after administration of antimicrobial agents in 172 cases of acute upper respiratory infection in patients aged 6 years or younger. The antimicrobial agents administered were amoxicillin (AMPC) (34%), clavulanic acid/amoxicillin compound (11%), cefditren pivoxil (CDTR-PI) (43%), and others (12%). Changes in nasopharyngeal bacterial flora were investigated with reexaminations conducted after 2-5 days (day 2-5 subgroup), 6-10 days (day 6-10 subgroup), and 11 days and thereafter. There was a significant reduction in the Streptococcus pneumoniae detected in the group administered AMPC (AMPC group) in the day 2-5 subgroup and the day 6-10 subgroup. There was also a significant decrease in H. influenzae in the group administered CDTR-PI (CDTR-PI group) in the day 2-5 subgroup. From this it was inferred that for the most part significant changes in infectious nasopharyngeal bacteria occurred in the day 2-5 subgroups. However, a significant improvement in the degree of inflammation, as indicated by leukocyte infiltration images for the AMPC group, was observed in the day 2-5 subgroup, and for the CDTR-PI group in the day 6-10 subgroup. On the other hand, in both the antimicrobial agent groups, S. pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis were newly detected at reexamination. Furthermore, a difference in the incidence of these bacteria was observed between the 2 antimicrobial agent groups. It was suggested that such phenomena related to the survival of resistant strains or a recurrence otitis media.
authors.affiliation: Teikyo University School of Medicine, Tokyo, Japan. mrsa@interlink.or.jp
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Konno
authors.forename: Shunkichi
authors.initials: S
authors.lastname: Baba
authors.forename: Haruki
authors.initials: H
authors.lastname: Mikawa
authors.forename: Kohei
authors.initials: K
authors.lastname: Hara
authors.forename: Fumio
authors.initials: F
authors.lastname: Matsumoto
authors.forename: Kimitaka
authors.initials: K
authors.lastname: Kaga
authors.forename: Tadao
authors.initials: T
authors.lastname: Nishimura
authors.forename: Toshimitsu
authors.initials: T
authors.lastname: Kobayashi
authors.forename: Nobuhiko
authors.initials: N
authors.lastname: Furuya
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Moriyama
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Okamoto
authors.forename: Mituru
authors.initials: M
authors.lastname: Furukawa
authors.forename: Noboru
authors.initials: N
authors.lastname: Yamanaka
authors.forename: Toshiharu
authors.initials: T
authors.lastname: Matsushima
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Yoshizawa
authors.forename: Shigeru
authors.initials: S
authors.lastname: Kohno
authors.forename: Kunihiko
authors.initials: K
authors.lastname: Kobayashi
authors.forename: Akihiro
authors.initials: A
authors.lastname: Morikawa
authors.forename: Shoichi
authors.initials: S
authors.lastname: Koizumi
authors.forename: Keisuke
authors.initials: K
authors.lastname: Sunakawa
authors.forename: Matsuhisa
authors.initials: M
authors.lastname: Inoue
authors.forename: Kimiko
authors.initials: K
authors.lastname: Ubukata
mesh_terms: D000890:Anti-Infective Agents / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D004351:Drug Resistance; D005260:Female; D006192:Haemophilus Infections / Q000382:microbiology; D006193:Haemophilus influenzae / Q000302:isolation & purification*; D006801:Humans; D007223:Infant; D008297:Male; D001936:Moraxella catarrhalis / Q000302:isolation & purification*; D045828:Moraxellaceae Infections / Q000382:microbiology; D009305:Nasopharynx / Q000187:drug effects / Q000382:microbiology*; D010033:Otitis Media / Q000188:drug therapy / Q000382:microbiology; D011008:Pneumococcal Infections / Q000382:microbiology; D016133:Polymerase Chain Reaction / Q000379:methods; D012141:Respiratory Tract Infections / Q000188:drug therapy* / Q000382:microbiology; D013296:Streptococcus pneumoniae / Q000302:isolation & purification*
chemical_list: D000890:Anti-Infective Agents