Auger electrons--a nanoprobe for structural, molecular and cellular processes.
This paper provides a brief review of recently published work on biophysical and biological aspects of Auger processes. Three specific questions have been considered. (1) Does charge neutralisation contribute to molecular damage such as DNA strand breaks? (2) How many DNA double strand breaks are produced by a single decay of DNA bound (125)I? (3) What is the correlation between number of gammaH2AX foci and number of double strand breaks (DSB)? The paper also gives preliminary reports on two new calculations: (a) calculation of the spectrum of Auger electrons released during decay of (124)I and (b) the use of Auger electrons in the decay of (125)I as a probing agent of novel DNA structures.
Nikjoo
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USRA, NASA Johnson Space Center, Houston, TX 77058, USA. Hooshang.nikjoo@jsc.nasa.gov
Girard
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Charlton
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Hofer
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Laughton
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D003198:Computer Simulation; D004247:DNA / Q000737:chemistry* / Q000528:radiation effects*; D004249:DNA Damage; D004583:Electrons; D007457:Iodine Radioisotopes / Q000737:chemistry*; D008954:Models, Biological; D008956:Models, Chemical; D015336:Molecular Probe Techniques
D007457:Iodine Radioisotopes; D004247:DNA