title: 1,3-Disubstituted-imidazo[1,5-a]pyrazines as insulin-like growth-factor-I receptor (IGF-IR) inhibitors.
abstract: A series of novel 8-amino-1,3-disubstituted-imidazo[1,5-a]pyrazines was designed and synthesized as IGF-IR inhibitors.
authors.affiliation: (OSI) Oncology, OSI Pharmaceuticals, Inc., 1 Bioscience Park Drive, Farmingdale, NY 11735, USA. mmulvihill@osip.com
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Mulvihill
authors.forename: Qun-Sheng
authors.initials: QS
authors.lastname: Ji
authors.forename: Doug
authors.initials: D
authors.lastname: Werner
authors.forename: Patricia
authors.initials: P
authors.lastname: Beck
authors.forename: Cara
authors.initials: C
authors.lastname: Cesario
authors.forename: Andrew
authors.initials: A
authors.lastname: Cooke
authors.forename: Matthew
authors.initials: M
authors.lastname: Cox
authors.forename: Andrew
authors.initials: A
authors.lastname: Crew
authors.forename: Hanqing
authors.initials: H
authors.lastname: Dong
authors.forename: Lixin
authors.initials: L
authors.lastname: Feng
authors.forename: K W
authors.initials: KW
authors.lastname: Foreman
authors.forename: Gilda
authors.initials: G
authors.lastname: Mak
authors.forename: Anthony
authors.initials: A
authors.lastname: Nigro
authors.forename: Matthew
authors.initials: M
authors.lastname: O'Connor
authors.forename: Lydia
authors.initials: L
authors.lastname: Saroglou
authors.forename: Kathryn M
authors.initials: KM
authors.lastname: Stolz
authors.forename: Izabela
authors.initials: I
authors.lastname: Sujka
authors.forename: Brian
authors.initials: B
authors.lastname: Volk
authors.forename: Qinghua
authors.initials: Q
authors.lastname: Weng
authors.forename: Robin
authors.initials: R
authors.lastname: Wilkes
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D019540:Area Under Curve; D001665:Binding Sites; D001682:Biological Availability; D018360:Crystallography, X-Ray; D030562:Databases, Protein; D006207:Half-Life; D007093:Imidazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D007202:Indicators and Reagents; D051379:Mice; D008958:Models, Molecular; D011505:Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors; D011719:Pyrazines / Q000138:chemical synthesis* / Q000494:pharmacology*; D017526:Receptor, IGF Type 1 / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship
chemical_list: D007093:Imidazoles; D007202:Indicators and Reagents; D011719:Pyrazines; D000255:Adenosine Triphosphate; D011505:Protein-Tyrosine Kinases; D017526:Receptor, IGF Type 1