[Conclusions, future prospects and recommendations].
Understanding the notion of oxidative stress implies a good knowledge of the reactivity of the different reactive oxygen species (ROS). Cell damage can be induced by an overproduction of these species and/or by a deficiency in the protective antioxidant systems. Nevertheless, ROS do not display only deleterious effects and play key-roles in cell signalisation and regulation of the expression of redox sensitive genes. Besides ROS, reactive nitrogen species (RNS) with nitric oxide (*NO) as leader element, are widely involved in biology and lead to the term "nitrosative stress" that particularly describes the damage induced by peroxynitrite, a species formed by reaction between superoxide anion and degrees NO. Nutritional strategies have been based on antioxidant-rich diets, or on supplementation with antioxidants; they could constitute adjunct therapies of interest. Given all these data, radical biochemistry must be considered as a specific discipline.
Bonnefont-Rousselot
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Laboratoire de Biochimie Métabolique et clinique (EA 3617), Faculté de Pharmacie Paris 5, 4, avenue de l'Observatoire, F 75270 Paris Cedex 06, France. dominique.rousselot@psl.aphp.fr
D000818:Animals; D006801:Humans; D016877:Oxidants / Q000378:metabolism; D018384:Oxidative Stress / Q000502:physiology*; D026361:Reactive Nitrogen Species / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism
D016877:Oxidants; D026361:Reactive Nitrogen Species; D017382:Reactive Oxygen Species