1-(N-chloroacetylamino)-alkylphosphonic acids - synthetic precursors of phosphonopeptides.
General procedures of N-chloroacetylation of the representative 1-aminoalkylphosphonic acids (Gly(P), Ala(P), Val(P), Pgly(P) and Phe(P)) are described. These 1-(N-chloroacetylamino)-alkylphosphonic acids were converted into the corresponding glycylphosphonodipeptides (Gly-AA(P)) and/or related N-alkylglycylphosphonodipeptides (Me(n)Gly-AA(P)) in the course of ammonolysis/aminolysis. Physico-chemical properties of synthesized 1-(N-chloroacetylamino)-alkylphosphonic acids and phosphonodipeptides are characterized.
Kudzin
Z H
ZH
Institute of Chemistry, University of Łódź, Łódź, Poland. zhk@chemul.uni.lodz.pl
Depczyński
R
R
Kudzin
M H
MH
Drabowicz
J
J
D000085:Acetates / Q000737:chemistry*; D000478:Alkylation; D000588:Amines / Q000737:chemistry*; D015394:Molecular Structure; D063065:Organophosphonates / Q000737:chemistry*; D010748:Phosphopeptides / Q000138:chemical synthesis* / Q000737:chemistry
D000085:Acetates; D000588:Amines; D063065:Organophosphonates; D010748:Phosphopeptides; C006972:chloroacetic acid