title: Hydroxy-PCBs, PBDEs, and HBCDDs in serum from an elderly population of Swedish fishermen's wives and associations with bone density.
abstract: Lack of human exposure data is frequently reported as a critical gap in risk assessments of environmental pollutants, especially regarding "new" pollutants. The objectives of this study were to assess serum levels of the persistent 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153), hydroxylated polychlorinated biphenyl metabolites (OH-PCBs), polybrominated diphenyl ethers (PBDEs), and hexabromocyclodode-canes (HBCDDs) in a group of Swedish middle-aged and elderly women expected to be relatively highly exposed, and to evaluate the impact of potential determinants (e.g., fish intake, age) for the inter-individual variation, as well as to investigate the association between these pollutants and bone density. No associations were found between bone mineral density or biochemical markers of bone metabolism and the analyzed environmental pollutants. Relatively high levels of CB-153 (median 260 ng/g fat) and sigma 3-OH-PCBs (median 1.7 ng/mL serum), and low concentrations of sigma6PBDEs (median 3.6 ng/g fat) were determined. Total level of HBCDDs in serum was quantified by gas chromatography with mass spectrometric detection (median 0.5 ng/g fat). HBCDD diastereomeric and enantiomeric patterns were determined by liquid chromatography with mass spectrometric detection. The dominating stereoisomer was (-)alpha-HBCDD, but 1-3% of gamma-HBCDD was also detected in the serum samples.
authors.affiliation: Department of Environmental Chemistry, Stockholm University, SE-10691 Stockholm, Sweden.
authors.forename: Jana
authors.initials: J
authors.lastname: Weiss
authors.forename: Ewa
authors.initials: E
authors.lastname: Wallin
authors.forename: Anna
authors.initials: A
authors.lastname: Axmon
authors.forename: Bo A G
authors.initials: BA
authors.lastname: Jönsson
authors.forename: Helene
authors.initials: H
authors.lastname: Akesson
authors.forename: Karel
authors.initials: K
authors.lastname: Janák
authors.forename: Lars
authors.initials: L
authors.lastname: Hagmar
authors.forename: Ake
authors.initials: A
authors.lastname: Bergman
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D015519:Bone Density; D002853:Chromatography, Liquid / Q000379:methods; D004785:Environmental Pollutants / Q000097:blood; D005260:Female; D005398:Fisheries; D006801:Humans; D006842:Hydrocarbons, Brominated / Q000097:blood*; D016014:Linear Models; D013058:Mass Spectrometry / Q000379:methods; D008875:Middle Aged; D011075:Polybrominated Biphenyls / Q000097:blood*; D011078:Polychlorinated Biphenyls / Q000097:blood*; D013548:Sweden; D014874:Water Pollutants, Chemical / Q000097:blood
chemical_list: D004785:Environmental Pollutants; D006842:Hydrocarbons, Brominated; D011075:Polybrominated Biphenyls; D014874:Water Pollutants, Chemical; C089796:hexabromocyclododecane; D011078:Polychlorinated Biphenyls