High-frequency oscillations in phrenic activity during pontile and medullary respiratory rhythms in rats.
High-frequency oscillations may be signatures of the basic mechanisms underlying the neurogenesis of various patterns of automatic ventilatory activity. These high-frequency oscillations in phrenic activity differ greatly in eupnoea and gasping, implying different mechanisms of neurogenesis. In a decerebrate, in situ preparation of the rat, the peak frequency of high-frequency oscillations fell in apneusis following removal of the rostral pons. Following removal of all pons, phrenic discharge had a mixed pattern of gasps and multiple bursts; some of the latter were incrementing, as in eupnoea. Regardless of pattern, peak frequencies were significantly below those which were found during eupnoea, apneusis or gasping of the decerebrate preparation. Results do not support the concept that 'non-gasping' rhythmic patterns that can be recorded following a removal of pons are generated by the same mechanisms as those generating eupnoea. Indeed, both pons and medulla appear essential for all aspects of eupnoea to be expressed.
St-John
Walter M
WM
Department of Physiology, Dartmouth Medical School, Dartmouth - Hitchcock Medical Center, Lebanon, NH 03756, USA. walter.m.stjohn@dartmouth.edu
Leiter
J C
JC
D000818:Animals; D003655:Decerebrate State; D004195:Disease Models, Animal; D020925:Hypoxia-Ischemia, Brain / Q000503:physiopathology*; D008526:Medulla Oblongata / Q000503:physiopathology*; D010791:Phrenic Nerve / Q000503:physiopathology*; D011149:Pons / Q000503:physiopathology* / Q000601:surgery; D051381:Rats; D012125:Respiratory Center / Q000503:physiopathology*; D015656:Respiratory Mechanics; D012137:Respiratory System / Q000294:innervation*