title: Online optical coherence pachymetry to evaluate intraoperative ablation parameters in LASIK.
abstract: OBJECTIVE
  The ablation of corneal tissue with the excimer laser can be variable and can lead to miscorrections. The purpose of this study was to evaluate intraoperative ablation parameters during laser-assisted in-situ keratomileusis (LASIK) with online optical coherence pachymetry (OCP).
  
  
  METHODS
  In a prospective, nonrandomized, comparative clinical study, the ablation parameters were continuously assessed intraoperatively with online OCP (Heidelberg Engineering, Lübeck, Germany) in 45 myopic and 10 hyperopic LASIK treatments. The central intraoperative ablation values were compared with the calculated values of the excimer laser (ESIRIS, Schwind, Germany) and the postoperative refraction. The ablation process and the ablation rate in mum per layer, time, and dioptric correction were evaluated in myopic corrections.
  
  
  RESULTS
  In myopic LASIK treatments, a linear ablation process was measured with a mean correlation coefficient of -0.968 +/- 0.04. The intraoperative ablation rate was, on average, 0.59 +/- 0.17 microm per layer, 1.45 +/- 0.48 microm per second, and 24.63 +/- 7.81 microm per corrected diopter. These values were 28.7% to 29.6% higher (P < 0.001) than the calculated values. There was a significant correlation (P < 0.001) for the ablation rate per layer (r = 0.823), per second (r = 0.869), and corrected diopter (r = 0.892), but no correlation (r = 0.21, P = 0.239) between the measured linear ablation process and the postoperative refraction. During hyperopic LASIK treatments, without ablation of the corneal center, there was a significant decrease (P = 0.005) of the stromal thickness by 18.34 +/- 14.13 microm, which corresponded to a mean corneal dehydration rate of 0.27 microm per second.
  
  
  CONCLUSIONS
  Online OCP allowed a clinical evaluation of intraoperative ablation parameters in LASIK. Further studies are needed to assess a possible active control of the excimer laser ablation from these continuous values, which could possibly improve current ablation nomograms.
authors.affiliation: Klinik für Augenheilkunde, Vivantes Klinikum Neukölln, Rudower Str. 48, 12351, Berlin, Germany. christopher.wirbelauer@vivantes.de
authors.forename: Christopher
authors.initials: C
authors.lastname: Wirbelauer
authors.forename: Henning
authors.initials: H
authors.lastname: Aurich
authors.forename: Duy Thoai
authors.initials: DT
authors.lastname: Pham
mesh_terms: D000328:Adult; D000368:Aged; D001251:Astigmatism / Q000503:physiopathology / Q000601:surgery*; D003315:Cornea / Q000473:pathology*; D003941:Diagnostic Techniques, Ophthalmological; D006801:Humans; D006956:Hyperopia / Q000503:physiopathology / Q000601:surgery*; D020731:Keratomileusis, Laser In Situ; D008875:Middle Aged; D016343:Monitoring, Intraoperative; D009216:Myopia / Q000503:physiopathology / Q000601:surgery*; D009862:Online Systems; D011446:Prospective Studies; D012029:Refraction, Ocular / Q000502:physiology; D013524:Surgical Flaps