title: Acute severe asthma: recent advances.
abstract: OBJECTIVE
  Acute severe asthma is challenging to the clinician both in terms of recognition and appropriate treatment. About 30% of these episodes need admission to the medical intensive care unit with a mortality of 8%. Relapse rates vary from 7 to 15% depending on how well the patient is managed. The purpose of this review is to discuss recent advances in identification of risk factors, pathophysiology and management of acute severe asthma.
  
  
  RESULTS
  Although the exact mechanism for acute severe asthma is unclear, some that are implicated include inflammation, airway remodeling and downregulation of beta-receptors. None of the environmental factors have been clearly related to the development of near fatal attacks. Genetic polymorphisms have been associated with severe asthma. Lack of steroid responsiveness has been linked to severe asthma attacks. Chemokines and basement membrane changes characteristic of severe asthma are reported in a few studies. Lack of symptom perception in a certain group of patients with acute severe asthma leads to delayed interventions. Specific treatment modalities and ventilator management is reviewed.
  
  
  CONCLUSIONS
  Severe asthma is a phenotype of asthma with variable pathology and clinical presentation. Early recognition and timely intervention is needed to prevent significant mortality and morbidity.
authors.affiliation: Pulmonary and Critical Care Medicine, Baylor College of Medicine, Houston, Texas 77030, USA.
authors.forename: Vaidehi
authors.initials: V
authors.lastname: Kaza
authors.forename: Venkata
authors.initials: V
authors.lastname: Bandi
authors.forename: Kalpalatha K
authors.initials: KK
authors.lastname: Guntupalli
mesh_terms: D000208:Acute Disease; D018927:Anti-Asthmatic Agents / Q000627:therapeutic use; D001249:Asthma / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology* / Q000628:therapy*; D006801:Humans; D010641:Phenotype; D011379:Prognosis; D018343:Receptors, Adrenergic, beta-2 / Q000502:physiology; D012121:Respiration, Artificial; D012307:Risk Factors
chemical_list: D018927:Anti-Asthmatic Agents; D018343:Receptors, Adrenergic, beta-2