title: Murine [corrected] myeloid dendritic cell-dependent toll-like receptor immunity is preserved with aging.
abstract: The immune response is the result of the interplay between innate and adaptive immunity, yet the impact of aging on this interaction is unclear. Addressing this fundamental question will be critical for the development of effective vaccines for the rapidly rising older subpopulation that manifests increased prevalence of malignancies and infections. Therefore, we undertook the current study to investigate whether aging impairs toll-like receptor (TLR) function in myeloid dendritic cells and whether this leads to reduced T-cell priming. Our results demonstrate that innate TLR immune priming function of myeloid bone marrow derived and splenic dendritic cells (DC) is preserved with aging using both allogeneic and infectious murine experimental systems. In contrast, aging impairs in vitro and in vivo intrinsic T-cell function. Therefore, our results demonstrate that myeloid DCs manifest preserved TLR-mediated immune responses with aging. However, aging critically impairs intrinsic adaptive T-cell function.
authors.affiliation: Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520-8018, USA.
authors.forename: Bethany M
authors.initials: BM
authors.lastname: Tesar
authors.forename: Wendy E
authors.initials: WE
authors.lastname: Walker
authors.forename: Julia
authors.initials: J
authors.lastname: Unternaehrer
authors.forename: Nikhil S
authors.initials: NS
authors.lastname: Joshi
authors.forename: Anmol
authors.initials: A
authors.lastname: Chandele
authors.forename: Laura
authors.initials: L
authors.lastname: Haynes
authors.forename: Susan
authors.initials: S
authors.lastname: Kaech
authors.forename: Daniel R
authors.initials: DR
authors.lastname: Goldstein
mesh_terms: D000222:Adaptation, Physiological / Q000276:immunology; D000375:Aging / Q000276:immunology*; D000818:Animals; D017951:Antigen Presentation / Q000276:immunology; D003713:Dendritic Cells / Q000276:immunology*; D007107:Immune System / Q000276:immunology* / Q000503:physiopathology; D007111:Immunity, Cellular / Q000276:immunology*; D007113:Immunity, Innate / Q000276:immunology; D008216:Lymphocytic Choriomeningitis / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D022423:Myeloid Cells / Q000166:cytology / Q000276:immunology; D013154:Spleen / Q000166:cytology / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*; D051193:Toll-Like Receptors / Q000276:immunology*
chemical_list: D051193:Toll-Like Receptors