title: Adherence therapy for people with schizophrenia. European multicentre randomised controlled trial.
abstract: BACKGROUND
  There is equivocal evidence of the effectiveness of adherence therapy in improving treatment adherence and clinical outcomes for people with schizophrenia.
  
  
  OBJECTIVE
  To evaluate the effectiveness of adherence therapy in improving quality of life for people with schizophrenia.
  
  
  METHODS
  A 52-week, single-blind, multicentre randomised controlled trial of the effectiveness of adherence therapy. Participants were individually randomised to receive eight sessions of adherence therapy or health education. Assessments were undertaken at baseline and at 52-week follow-up.
  
  
  RESULTS
  Adherence therapy was no more effective than health education in improving quality of life.
  
  
  CONCLUSIONS
  This effectiveness trial provides evidence for the lack of effect of adherence therapy in people with schizophrenia with recent clinical instability, treated in ordinary clinical settings.
authors.affiliation: Health Services Department, Institute of Psychiatry, King's College London, De Crespigny Park, London SE5 8AF, UK. R.Gray@iop.kcl.ac.uk
authors.forename: Richard
authors.initials: R
authors.lastname: Gray
authors.forename: Morven
authors.initials: M
authors.lastname: Leese
authors.forename: Jonathan
authors.initials: J
authors.lastname: Bindman
authors.forename: Thomas
authors.initials: T
authors.lastname: Becker
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Burti
authors.forename: Anthony
authors.initials: A
authors.lastname: David
authors.forename: Kevin
authors.initials: K
authors.lastname: Gournay
authors.forename: Martijn
authors.initials: M
authors.lastname: Kikkert
authors.forename: Maarten
authors.initials: M
authors.lastname: Koeter
authors.forename: Bernd
authors.initials: B
authors.lastname: Puschner
authors.forename: Aart
authors.initials: A
authors.lastname: Schene
authors.forename: Graham
authors.initials: G
authors.lastname: Thornicroft
authors.forename: Michele
authors.initials: M
authors.lastname: Tansella
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D005060:Europe; D005260:Female; D006266:Health Education / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010342:Patient Acceptance of Health Care; D011788:Quality of Life; D012559:Schizophrenia / Q000628:therapy*; D016037:Single-Blind Method; D016896:Treatment Outcome
chemical_list: D014150:Antipsychotic Agents