Cytotoxicity of partial-stabilized cement.
Partial-stabilized cement (PSC) is a kind of modified calcium silicate cement used for root-end surgery. Minor transition metal elements Co, Cr, and Zn were added for enhancing the setting property of to PSC. In our previous study, minor transition metal additions greatly improved the setting property of PSC. However, the concern of metal toxicity was raised, as the material would be used in the human body. In this study, we evaluated the cytotoxicity of PSC in comparison with mineral trioxide aggregate (MTA), which is one of the commercialized materials used for dental root-end filling. Primary osteoblast cell was used as the target cell. Cell proliferation, cytotoxicity, viability, function, and senescence were analyzed. The cytotoxicity of the PSC-Zn group (PSC with Zn addition) was similar to that of MTA. PSC-Zn is not only nontoxic at the cellular level but also has adequate mechanical property, which makes it a potential root-end filling material for apical surgery.
Wang
Wen-Hsi
WH
Institute of Biomedical Engineering, National Taiwan University, Taiwan.
Lin
Feng-Huei
FH
Lee
Yuan-Ling
YL
Lin
Chun-Pin
CP
D000818:Animals; D049109:Cell Proliferation; D002470:Cell Survival; D002478:Cells, Cultured; D016922:Cellular Senescence; D010006:Osteoblasts / Q000166:cytology*; D051381:Rats; D017208:Rats, Wistar; D012387:Root Canal Filling Materials / Q000009:adverse effects; D012823:Silicate Cement / Q000009:adverse effects; D014131:Trace Elements / Q000009:adverse effects
D012387:Root Canal Filling Materials; D014131:Trace Elements; D012823:Silicate Cement