title: International Union of Pharmacology. LXII. The NR1H and NR1I receptors: constitutive androstane receptor, pregnene X receptor, farnesoid X receptor alpha, farnesoid X receptor beta, liver X receptor alpha, liver X receptor beta, and vitamin D receptor.
abstract: The nuclear receptors of the NR1H and NR1I subgroups include the constitutive androstane receptor, pregnane X receptor, farnesoid X receptors, liver X receptors, and vitamin D receptor. The newly emerging functions of these related receptors are under the control of metabolic pathways, including metabolism of xenobiotics, bile acids, cholesterol, and calcium. This review summarizes results of structural, pharmacologic, and genetic studies of these receptors.
authors.affiliation: Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA. moore@bcm.tmc.edu
authors.forename: David D
authors.initials: DD
authors.lastname: Moore
authors.forename: Shigeaki
authors.initials: S
authors.lastname: Kato
authors.forename: Wen
authors.initials: W
authors.lastname: Xie
authors.forename: David J
authors.initials: DJ
authors.lastname: Mangelsdorf
authors.forename: Daniel R
authors.initials: DR
authors.lastname: Schmidt
authors.forename: Rui
authors.initials: R
authors.lastname: Xiao
authors.forename: Steven A
authors.initials: SA
authors.lastname: Kliewer
mesh_terms: D000818:Animals; D000090702:Constitutive Androstane Receptor; D004268:DNA-Binding Proteins / Q000235:genetics / Q000502:physiology*; D006801:Humans; D000071518:Liver X Receptors; D009154:Mutation; D057093:Orphan Nuclear Receptors; D000077297:Pregnane X Receptor; D018167:Receptors, Calcitriol / Q000235:genetics / Q000502:physiology*; D018160:Receptors, Cytoplasmic and Nuclear / Q000145:classification / Q000235:genetics / Q000502:physiology*; D011987:Receptors, Steroid / Q000235:genetics / Q000502:physiology*; D009626:Terminology as Topic; D014157:Transcription Factors / Q000235:genetics / Q000502:physiology*; D000099150:Receptor, Farnesoid X-Activated
chemical_list: D000090702:Constitutive Androstane Receptor; D004268:DNA-Binding Proteins; D000071518:Liver X Receptors; D057093:Orphan Nuclear Receptors; D000077297:Pregnane X Receptor; D018167:Receptors, Calcitriol; D018160:Receptors, Cytoplasmic and Nuclear; D011987:Receptors, Steroid; D014157:Transcription Factors; D000099150:Receptor, Farnesoid X-Activated; C000605213:NR1H3 protein, human