Donor cell-derived acute myeloblastic leukemia after allogeneic peripheral blood hematopoietic stem cell transplantation for juvenile myelomonocytic leukemia.
Despite its rarity, donor cell leukemia (DCL) is a most intriguing entity. We report here the case of a 5 year-old girl with juvenile myelomonocytic leukemia and normal female karyotype who developed acute myeloblastic leukemia with a karyotype of 46, X, t(X; 7) (p21; p11.2), der(7) t(3; 7) (q13.3; q22) 5 months after peripheral blood hematopoietic stem cell transplantation from her HLA-matched sister. We performed the analysis of short tandem repeat sequence markers to DNA obtained from donor peripheral blood, patient's peripheral blood including leukemic blasts and patient's hair root. This analysis showed that the leukemic blood DNA matched the donor blood DNA and not the patient's DNA, thus confirming DCL. To our knowledge, this is the first case of DCL after peripheral blood SCT for juvenile myelomonocytic leukemia.
Cetin
Zafer
Z
Department of Pediatrics, Akdeniz University, Antalya, Turkey.
Tezcan
Gulsun
G
Karauzum
Sibel Berker
SB
Kupesiz
Alphan
A
Manguoglu
Ayse Esra
AE
Yesilipek
Akif
A
Luleci
Guven
G
Hazar
Volkan
V
D001782:Blood Donors; D002675:Child, Preschool; D002869:Chromosome Aberrations; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000209:etiology*; D015477:Leukemia, Myelomonocytic, Chronic / Q000150:complications / Q000235:genetics / Q000628:therapy*; D016609:Neoplasms, Second Primary; D036102:Peripheral Blood Stem Cell Transplantation / Q000009:adverse effects*; D018183:Transplantation Chimera / Q000235:genetics; D014184:Transplantation, Homologous