Maternal obesity in early pregnancy and risk of spontaneous and elective preterm deliveries: a retrospective cohort study.
OBJECTIVE
We sought to determine the association between maternal body mass index and risk of preterm delivery.


METHODS
We assessed 187,290 women in Scotland and estimated adjusted odds ratios for spontaneous and elective preterm deliveries among overweight, obese, and morbidly obese women relative to normal-weight women.


RESULTS
Among nulliparous women, the risk of requiring an elective preterm delivery increased with increasing BMI, whereas the risk of spontaneous preterm labor decreased. Morbidly obese nulliparous women were at increased risk of all-cause preterm deliveries, neonatal death, and delivery of an infant weighing less than 1000 g who survived to 1 year of age (a proxy for severe long-term disability). By contrast, obesity and elective preterm delivery were only weakly associated among multiparous women.


CONCLUSIONS
Obese nulliparous women are at increased risk of elective preterm deliveries. This in turn leads to an increased risk of perinatal mortality and is likely to lead to increased risks of long-term disability among surviving offspring.
Smith
Gordon C S
GC
Department of Obstetrics and Gynaecology, Cambridge University, Rosie Maternity Hospital, Cambridge, England. gcss2@cam.ac.uk
Shah
Imran
I
Pell
Jill P
JP
Crossley
Jennifer A
JA
Dobbie
Richard
R
D000328:Adult; D015992:Body Mass Index; D015331:Cohort Studies; D036861:Delivery, Obstetric / Q000379:methods; D017558:Elective Surgical Procedures / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D008429:Maternal Welfare; D009765:Obesity / Q000150:complications / Q000453:epidemiology*; D007752:Obstetric Labor, Premature; D016017:Odds Ratio; D050177:Overweight; D010298:Parity; D011247:Pregnancy; D011256:Pregnancy Outcome / Q000453:epidemiology*; D018566:Pregnancy, High-Risk; D047928:Premature Birth / Q000453:epidemiology* / Q000209:etiology; D018570:Risk Assessment; D012307:Risk Factors; D012606:Scotland / Q000453:epidemiology