title: Intra-arterial administration of fasudil hydrochloride for vasospasm following subarachnoid hemorrhage - analysis of time-density curve with digital subtraction angiography.
abstract: The cerebral circulatory dynamics were evaluated before and after intra-arterial administration of fasudil hydrochloride in 20 patients with angiographic vasospasm after subarachnoid hemorrhage (SAH). The region of interest time-density curves obtained before and after intra-arterial administration of fasudil hydrochloride were compared in the proximal portion of the middle cerebral artery in the early arterial phase, the distal portion of the middle cerebral artery in the late arterial phase, and the transverse sinus in the venous phase. In the early arterial phase, the time to peak and the time to half-peak were significantly reduced. In the late arterial phase and venous phase, the time to peak was significantly reduced. These results suggest that intra-arterial administration of fasudil hydrochloride induced dilation of the proximal arteries, and improved cerebral microcirculation. The present study suggests that intra-arterial administration of fasudil hydrochloride is effective as a treatment for vasospasm following SAH.
authors.affiliation: The Department of Neurosurgery, Toho University Ohashi Medical Center, Tokyo, Japan. iwabuchi@med.toho-u.ac.jp
authors.forename: Satoshi
authors.initials: S
authors.lastname: Iwabuchi
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Yokouchi
authors.forename: Morito
authors.initials: M
authors.lastname: Hayashi
authors.forename: Hideo
authors.initials: H
authors.lastname: Uehara
authors.forename: Morikazu
authors.initials: M
authors.lastname: Ueda
authors.forename: Hirotsugu
authors.initials: H
authors.lastname: Samejima
mesh_terms: D019307:1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D000328:Adult; D000368:Aged; D015901:Angiography, Digital Subtraction / Q000379:methods*; D001921:Brain / Q000098:blood supply / Q000503:physiopathology; D002536:Cerebral Arteries / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000503:physiopathology; D002560:Cerebrovascular Circulation / Q000187:drug effects / Q000502:physiology; D003287:Contrast Media / Q000493:pharmacokinetics; D003392:Cranial Sinuses / Q000000981:diagnostic imaging / Q000187:drug effects / Q000503:physiopathology; D005260:Female; D006801:Humans; D007269:Injections, Intra-Arterial / Q000379:methods / Q000592:standards; D008297:Male; D008875:Middle Aged; D020768:Middle Cerebral Artery / Q000000981:diagnostic imaging / Q000187:drug effects / Q000503:physiopathology; D013345:Subarachnoid Hemorrhage / Q000150:complications* / Q000503:physiopathology; D013997:Time Factors; D016896:Treatment Outcome; D014664:Vasodilation / Q000187:drug effects / Q000502:physiology; D014665:Vasodilator Agents / Q000008:administration & dosage; D020301:Vasospasm, Intracranial / Q000000981:diagnostic imaging* / Q000188:drug therapy* / Q000209:etiology
chemical_list: D003287:Contrast Media; D014665:Vasodilator Agents; D019307:1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; C049347:fasudil