title: Enantioselective enzymatic reductions of sterically bulky aryl alkyl ketones catalyzed by a NADPH-dependent carbonyl reductase.
abstract: The enantioselective reductions of aryl alkyl ketones, ArC(O)R, with a diverse number of alkyl groups have been achieved with an isolated carbonyl reductase from Sporobolomyces salmonicolor. Of special interest is the observation that ketones with sterically bulky alkyl groups could be reduced to the corresponding alcohols in excellent optical purity. An unusual alkyl chain-induced enantiopreference reversal was observed but was shown to be consistent with the enzyme-substrate docking calculations.
authors.affiliation: Department of Chemistry, Southern Methodist University, Dallas, Texas 75275, USA.
authors.forename: Dunming
authors.initials: D
authors.lastname: Zhu
authors.forename: Ling
authors.initials: L
authors.lastname: Hua
mesh_terms: D000429:Alcohol Oxidoreductases / Q000737:chemistry*; D000449:Aldehyde Reductase; D000074408:Aldo-Keto Reductases; D007659:Ketones / Q000737:chemistry*; D008958:Models, Molecular; D013237:Stereoisomerism
chemical_list: D007659:Ketones; D000429:Alcohol Oxidoreductases; D000074408:Aldo-Keto Reductases; D000449:Aldehyde Reductase