A comparison of cellular irradiation techniques with alpha particles using the Geant4 Monte Carlo simulation toolkit.
A comparison of three cellular irradiation techniques using the Monte Carlo simulation toolkit Geant4 is presented in this paper. They involve electrodeposited source of alpha particle-emitting radionuclides, random classical alpha beam irradiation and single cell targeted irradiation using a focused alpha microbeam line. The simulation allows the calculation of hit distributions among the cellular population as well as the absorbed dose for two typical cellular geometries.
Incerti
S
S
Centre d'Etudes Nucléaires de Bordeaux-Gradignan, CNRS/IN2P3, Université Bordeaux 1, Le Haut Vigneau, Gradignan cedex, France. incerti@cenbg.in2p3.fr
Gault
N
N
Habchi
C
C
Lefaix
J L
JL
Moretto
Ph
P
Poncy
J L
JL
Pouthier
T
T
Seznec
H
H
D000512:Alpha Particles; D018929:Cell Culture Techniques / Q000379:methods*; D002468:Cell Physiological Phenomena / Q000528:radiation effects*; D003198:Computer Simulation; D004307:Dose-Response Relationship, Radiation; D008954:Models, Biological; D015233:Models, Statistical; D009010:Monte Carlo Method; D010315:Particle Accelerators; D011829:Radiation Dosage; D011874:Radiometry / Q000379:methods*; D015203:Reproducibility of Results; D012542:Scattering, Radiation; D012680:Sensitivity and Specificity; D012984:Software