Convergent assembly of polycyclic ethers via acyl radical addition to unactivated enol ether.
A new convergent strategy for assembling 6/6- and 6/7-fused ether ring systems was developed. The key features in our method include Ag+-promoted facile formation of chemically labile enol ether from O,S-acetal and addition of an acyl radical to unactivated enol ether to cyclize a six- or seven-membered ether ring. [reaction: see text]
Inoue
Masayuki
M
Department of Chemistry, Graduate School of Science, Tohoku University, Sendai 980-8578, Japan. inoue@ykbsc.chem.tohoku.ac.jp
Ishihara
Yuuki
Y
Yamashita
Shuji
S
Hirama
Masahiro
M
D000080:Acetals; D000215:Acylation; D003500:Cyclization; D004987:Ethers / Q000138:chemical synthesis* / Q000737:chemistry; D007202:Indicators and Reagents; D011083:Polycyclic Compounds / Q000138:chemical synthesis*; D013237:Stereoisomerism
D000080:Acetals; D004987:Ethers; D007202:Indicators and Reagents; D011083:Polycyclic Compounds