[Cytomegalovirus infection of allografted kidneys in children].
The study was based on 90 puncture bioptats of transplanted kidneys, received from 67 patients (33 males and 34 females) aged 8 to 18 or 14.1 +/- 4.7 years. The puncture biopsies were performed 8 days to 7 years after renal transplantation. In addition to histological techniques, the researchers used immunoperoxidase method with monoclonal antibodies to CMV-E and CMV-L antigens. The immunohistochemical method of CMV infection diagnostics revealed CMV infection in 15 (17.5%) of the bioptats of the renal allografts. The risk of CMV infection in renal transplants increases during the late postoperative period in the presence of chronic pathology (chronic nephropathy or chronic glomerulonephritis), especially in combination with late acute allograft rejection crises.
Il'inskiĭ
I M
IM
Rotova
I D
ID
Kurenkova
L G
LG
Kabak
M M
MM
D000293:Adolescent; D000914:Antibodies, Viral / Q000276:immunology; D000956:Antigens, Viral / Q000276:immunology; D001706:Biopsy; D002648:Child; D003587:Cytomegalovirus / Q000276:immunology; D003586:Cytomegalovirus Infections / Q000209:etiology* / Q000473:pathology / Q000821:virology; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects* / Q000473:pathology; D008297:Male; D011183:Postoperative Complications; D011379:Prognosis; D014184:Transplantation, Homologous
D000914:Antibodies, Viral; D000956:Antigens, Viral