title: Chiral diols: a new class of additives for direct aldol reaction catalyzed by L-proline.
abstract: Nine C2 symmetric diols have been examined as additives in the L-proline-catalyzed direct aldol reaction with significant improvement in enantioselectivity, conversion efficiency, and yield. Loading of 1 mol % of (S)-BINOL leads to the desired products in up to 98% ee and 90% yield. A transition state is proposed.
authors.affiliation: Department of Chemistry, Wuhan University, Wuhan 430072, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhou
authors.forename: Zixing
authors.initials: Z
authors.lastname: Shan
mesh_terms: D000438:Alcohols / Q000737:chemistry*; D002384:Catalysis; D011392:Proline / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000438:Alcohols; D011392:Proline