Severe acute toxicity associated with high-dose methotrexate (MTX) therapy: use of therapeutic drug monitoring and test-dose to guide carboxypeptidase G2 rescue and MTX continuation.
Estève
M-A
MA
Laboratoire de Pharmacocinétique et de Toxicocinétique, CHU Timone, 254 rue St Pierre, 13005 Marseille, France.
Devictor-Pierre
B
B
Galy
G
G
André
N
N
Coze
C
C
Lacarelle
B
B
Bernard
J-L
JL
Monjanel-Mouterde
S
S
D000293:Adolescent; D000931:Antidotes / Q000008:administration & dosage* / Q000627:therapeutic use; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage* / Q000097:blood / Q000506:poisoning*; D001859:Bone Neoplasms / Q000188:drug therapy; D016903:Drug Monitoring / Q000379:methods; D005260:Female; D006801:Humans; D008727:Methotrexate / Q000008:administration & dosage* / Q000097:blood / Q000506:poisoning*; D012516:Osteosarcoma / Q000188:drug therapy; D011623:gamma-Glutamyl Hydrolase / Q000008:administration & dosage* / Q000627:therapeutic use
D000931:Antidotes; D000964:Antimetabolites, Antineoplastic; D011623:gamma-Glutamyl Hydrolase; D008727:Methotrexate