title: A comparison of cellular irradiation techniques with alpha particles using the Geant4 Monte Carlo simulation toolkit.
abstract: A comparison of three cellular irradiation techniques using the Monte Carlo simulation toolkit Geant4 is presented in this paper. They involve electrodeposited source of alpha particle-emitting radionuclides, random classical alpha beam irradiation and single cell targeted irradiation using a focused alpha microbeam line. The simulation allows the calculation of hit distributions among the cellular population as well as the absorbed dose for two typical cellular geometries.
authors.affiliation: Centre d'Etudes Nucléaires de Bordeaux-Gradignan, CNRS/IN2P3, Université Bordeaux 1, Le Haut Vigneau, Gradignan cedex, France. incerti@cenbg.in2p3.fr
authors.forename: S
authors.initials: S
authors.lastname: Incerti
authors.forename: N
authors.initials: N
authors.lastname: Gault
authors.forename: C
authors.initials: C
authors.lastname: Habchi
authors.forename: J L
authors.initials: JL
authors.lastname: Lefaix
authors.forename: Ph
authors.initials: P
authors.lastname: Moretto
authors.forename: J L
authors.initials: JL
authors.lastname: Poncy
authors.forename: T
authors.initials: T
authors.lastname: Pouthier
authors.forename: H
authors.initials: H
authors.lastname: Seznec
mesh_terms: D000512:Alpha Particles; D018929:Cell Culture Techniques / Q000379:methods*; D002468:Cell Physiological Phenomena / Q000528:radiation effects*; D003198:Computer Simulation; D004307:Dose-Response Relationship, Radiation; D008954:Models, Biological; D015233:Models, Statistical; D009010:Monte Carlo Method; D010315:Particle Accelerators; D011829:Radiation Dosage; D011874:Radiometry / Q000379:methods*; D015203:Reproducibility of Results; D012542:Scattering, Radiation; D012680:Sensitivity and Specificity; D012984:Software