title: Differences in blood pregnenolone and dehydroepiandrosterone levels between schizophrenia patients and healthy subjects.
abstract: OBJECTIVE
  Contradictory and confusing reports on serum dehydroepiandrosterone (DHEA) levels in schizophrenia led us to compare the serum concentration of its precursor, pregnenolone (PREG), between medicated schizophrenia patients and healthy subjects. The neurosteroid levels were monitored for two months and the relationship of these neurosteroids with schizophrenic symptomatology, emotional distress, and anxiety was examined.
  
  
  METHODS
  We determined blood levels of PREG, and DHEA in 15 schizophrenia patients and 12 healthy controls at four time points: at the start of the study, after 2, 4 and 8 weeks. Analysis of covariance and canonical correlations across four time points were applied.
  
  
  RESULTS
  Controlling for age, serum concentrations of PREG were lower, while the DHEA level and the molar ratio values of DHEA/PREG were higher in schizophrenia patients compared to healthy controls. Both levels of PREG and DHEA and their molar ratio did not change significantly during the study's period either among schizophrenia patients or healthy controls. The blood levels of PREG appear to be associated with trait-anxiety scores in the schizophrenia patients, while associations of clinical symptoms with two neurosteroids did not reach a significant level when the confounding effect of emotional distress, and anxiety scores was controlled.
  
  
  CONCLUSIONS
  Low serum pregnenolone concentrations in schizophrenia appear to be associated with trait-anxiety scores independent of symptoms. Further research into the role of pregnenolone in schizophrenia is warranted.
authors.affiliation: Sha'ar Menashe Mental Health Center, Mobile Post Hefer 38814, Israel. ritsner@shaar-menashe.org.il
authors.forename: Michael
authors.initials: M
authors.lastname: Ritsner
authors.forename: Rachel
authors.initials: R
authors.lastname: Maayan
authors.forename: Anatoly
authors.initials: A
authors.lastname: Gibel
authors.forename: Abraham
authors.initials: A
authors.lastname: Weizman
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D003687:Dehydroepiandrosterone / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011284:Pregnenolone / Q000097:blood*; D011863:Radioimmunoassay / Q000379:methods; D012559:Schizophrenia / Q000097:blood*; D013223:Statistics as Topic; D013997:Time Factors
chemical_list: D003687:Dehydroepiandrosterone; D011284:Pregnenolone