A new monoterpene glycoside and antibacterial monoterpene glycosides from Paeonia suffruticosa.
Antibacterial activity-guided fractionation of the CHCI3-MeOH (1:1) extract of Paeonia suffruticosa root bark furnished three monoterpene glycosides, 6-O-vanillyoxypaeoniflorin (1), mudanpioside-H (2), and galloyl-oxypaeoniflorin (3). Of the isolated compounds, compound 1 is a new compound. All isolated compounds showed broad, but moderate, antibacterial activity with minimum inhibitory concentration (MIC) values in the range of 100 to 500 microg/mL against eighteen pathogenic microorganisms of concern for public health or zoonosis.
An
Ren-Bo
RB
College of Pharmacy, Wonkwang University, Iksan 570-749, Korea.
Kim
Hyun-Chul
HC
Lee
Sung-Hee
SH
Jeong
Gil-Saeng
GS
Sohn
Dong-Hwan
DH
Park
Hyun
H
Kwon
Dong-Yeul
DY
Lee
John Hwa
JH
Kim
Youn-Chul
YC
D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D004926:Escherichia coli / Q000145:classification / Q000187:drug effects / Q000254:growth & development; D005707:Gallic Acid / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D016106:Methicillin Resistance / Q000187:drug effects / Q000235:genetics; D008826:Microbial Sensitivity Tests / Q000379:methods; D015394:Molecular Structure; D039821:Monoterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D029596:Paeonia / Q000737:chemistry*; D018517:Plant Roots / Q000737:chemistry; D012477:Salmonella enteritidis / Q000145:classification / Q000187:drug effects / Q000254:growth & development; D012763:Shigella flexneri / Q000187:drug effects / Q000254:growth & development; D013211:Staphylococcus aureus / Q000187:drug effects / Q000235:genetics / Q000254:growth & development; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D014734:Vibrio cholerae / Q000187:drug effects / Q000254:growth & development
C517302:6-O-vanillyoxypaeoniflorin; D000900:Anti-Bacterial Agents; D005960:Glucosides; D006027:Glycosides; D039821:Monoterpenes; D014315:Triterpenes; C111733:mudanpinoic acid; C517303:mudanpioside H; C077821:galloyloxypaeoniflorin; D005707:Gallic Acid