Fluvoxamine effects on concurrent ethanol- and food-maintained behaviors.
In previous studies, the selective serotonin reuptake inhibitor fluvoxamine preferentially reduced responding for ethanol compared with responding for food under conditions in which each was available alone in separate groups or in the same subjects under a multiple schedule in which baseline response rates were matched. The impact of providing concurrent access to food on pharmacological effects on ethanol self-administration remains largely unexplored. In this study, acute doses of fluvoxamine (3.0-17.8 mg/kg) were administered 30 min before the experimental session to Lewis rats responding under a concurrent fixed-ratio, fixed-ratio schedule of ethanol and food presentation. Ratios for food were adjusted for each subject to provide matched rates of food and ethanol reinforcement across the 30-min session. Although the number of ethanol and food deliveries did not significantly differ under baseline conditions, response rates did differ. Following fluvoxamine administration, responding for food was decreased more than responding for ethanol. This differential effect did not appear to be related to response rate or fixed-ratio size. Thus, the selectivity of fluvoxamine on ethanol- versus food-maintained responding depends on the context in which the behavior occurs. Such results may help explain inconsistencies between preclinical results and those in humans, and could provide insight into the behavioral determinants of pharmacological effects on ethanol self-administration.
Ginsburg
Brett C
BC
Department of Psychiatry, University of Texas Health Science Center, San Antonio, TX 78228, USA. ginsburg@uthscsa.edu
Lamb
R J
RJ
D000818:Animals; D018687:Antidepressive Agents, Second-Generation / Q000494:pharmacology*; D002492:Central Nervous System Depressants / Q000494:pharmacology*; D003216:Conditioning, Operant / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000494:pharmacology*; D016666:Fluvoxamine / Q000494:pharmacology*; D005502:Food; D016014:Linear Models; D008297:Male; D051381:Rats; D011917:Rats, Inbred Lew; D012055:Reinforcement Schedule; D012054:Reinforcement, Psychology
D018687:Antidepressive Agents, Second-Generation; D002492:Central Nervous System Depressants; D000431:Ethanol; D016666:Fluvoxamine