Adherence therapy for people with schizophrenia. European multicentre randomised controlled trial.
BACKGROUND
There is equivocal evidence of the effectiveness of adherence therapy in improving treatment adherence and clinical outcomes for people with schizophrenia.


OBJECTIVE
To evaluate the effectiveness of adherence therapy in improving quality of life for people with schizophrenia.


METHODS
A 52-week, single-blind, multicentre randomised controlled trial of the effectiveness of adherence therapy. Participants were individually randomised to receive eight sessions of adherence therapy or health education. Assessments were undertaken at baseline and at 52-week follow-up.


RESULTS
Adherence therapy was no more effective than health education in improving quality of life.


CONCLUSIONS
This effectiveness trial provides evidence for the lack of effect of adherence therapy in people with schizophrenia with recent clinical instability, treated in ordinary clinical settings.
Gray
Richard
R
Health Services Department, Institute of Psychiatry, King's College London, De Crespigny Park, London SE5 8AF, UK. R.Gray@iop.kcl.ac.uk
Leese
Morven
M
Bindman
Jonathan
J
Becker
Thomas
T
Burti
Lorenzo
L
David
Anthony
A
Gournay
Kevin
K
Kikkert
Martijn
M
Koeter
Maarten
M
Puschner
Bernd
B
Schene
Aart
A
Thornicroft
Graham
G
Tansella
Michele
M
D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D005060:Europe; D005260:Female; D006266:Health Education / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010342:Patient Acceptance of Health Care; D011788:Quality of Life; D012559:Schizophrenia / Q000628:therapy*; D016037:Single-Blind Method; D016896:Treatment Outcome
D014150:Antipsychotic Agents