title: [Preparation of cytarabine nanoparticle and study on the drug releasing mechanism].
abstract: Cytarabine nanoparticle was prepared through emulsion polymerization method, and its releasing properties were studied. The results showed that releasing principle complied with biexponential equation and had characteristics of sustained releasing. The pharmacokinetics in rabbits complied with two-department model. Compared with cytarabine injection, cytarabine nanoparticle had prolonged t 1/2beta and MRT and reduced CL, which showed nanoparticle could significantly prolong the retention time of Ara-C and possess significant sustained releasing character.
authors.affiliation: School of Pharmacy, Sichuan University, Chengdu 610041, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhou
authors.forename: Shu
authors.initials: S
authors.lastname: Lin
authors.forename: Xuehua
authors.initials: X
authors.lastname: Jiang
authors.forename: Junyi
authors.initials: J
authors.lastname: Yang
mesh_terms: D000818:Animals; D003561:Cytarabine / Q000493:pharmacokinetics*; D003692:Delayed-Action Preparations; D004339:Drug Compounding / Q000379:methods*; D053758:Nanoparticles; D011817:Rabbits
chemical_list: D003692:Delayed-Action Preparations; D003561:Cytarabine