Management of sepsis.
Severe sepsis remains a common cause of death in surgical patients. Eradication of the septic source and supportive care has long been the mainstay of treatment. In recent years, however, early goal-directed therapy, tighter glucose control, administration of drotrecogin alfa (activated), and steroid replacement have produced improved morbidity and mortality. In the future, a better understanding of the pathophysiology of sepsis and clinical studies may further improve outcomes from severe sepsis.
Howell
Gina
G
University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.
Tisherman
Samuel A
SA
D003422:Critical Care; D016638:Critical Illness; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage; D007328:Insulin / Q000008:administration & dosage; D017582:Renal Replacement Therapy; D012151:Resuscitation; D018805:Sepsis / Q000453:epidemiology / Q000503:physiopathology / Q000628:therapy*; D013514:Surgical Procedures, Operative; D015912:Thrombolytic Therapy
D005938:Glucocorticoids; D007004:Hypoglycemic Agents; D007328:Insulin