Antimalarial activity of concanamycin A alone and in combination with pyronaridine.
Concanamycin A, a macrolide antibiotic inhibitor of vacuolar H+-ATPase derived from Streptomyces sp, inhibited Plasmodium falciparum K1 growth in culture with an IC500 value of 0.2 nM. It exhibited an additive effect when tested together with the antimalarial pyronaridine.
Auparakkitanon
Saranya
S
Division of Toxicology, Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand. rasao@mahidol.ac.th
Wilairat
Prapon
P
D000818:Animals; D000962:Antimalarials / Q000633:toxicity*; D020128:Inhibitory Concentration 50; D018942:Macrolides / Q000633:toxicity*; D009287:Naphthyridines / Q000633:toxicity*; D010963:Plasmodium falciparum / Q000187:drug effects*
D000962:Antimalarials; D018942:Macrolides; D009287:Naphthyridines; C036978:concanamycin A; C027871:pyronaridine