title: Copper(I)-catalyzed chlorine atom transfer radical cyclization reactions of unsaturated alpha-chloro beta-keto esters.
abstract: Copper(I) chloride catalyzed chlorine atom transfer radical cyclization reactions of a series of olefinic alpha-chloro beta-keto esters were investigated. It was found that alpha-dichlorinated beta-keto esters were suitable substrates; the chlorine transfer mono or tandem radical cyclization reactions catalyzed by CuCl complex with bis(oxazoline) or bipyridine proceeded smoothly in dichloroethane at room temperature or 80 degrees C, providing cyclic and bicyclic compounds in moderate to high yield. [reaction: see text]
authors.affiliation: Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, P. R. China. yangdan@hku.hk
authors.forename: Dan
authors.initials: D
authors.lastname: Yang
authors.forename: Yi-Long
authors.initials: YL
authors.lastname: Yan
authors.forename: Bao-Fu
authors.initials: BF
authors.lastname: Zheng
authors.forename: Qiang
authors.initials: Q
authors.lastname: Gao
authors.forename: Nian-Yong
authors.initials: NY
authors.lastname: Zhu
mesh_terms: D002384:Catalysis; D002713:Chlorine / Q000737:chemistry*; D003300:Copper / Q000737:chemistry*; D003500:Cyclization; D004952:Esters / Q000138:chemical synthesis; D005609:Free Radicals; D010080:Oxazoles / Q000737:chemistry
chemical_list: D004952:Esters; D005609:Free Radicals; D010080:Oxazoles; C064210:oxazolidine; D002713:Chlorine; D003300:Copper; C029892:cupric chloride