Clinical effect of a triclosan containing dentifrice on gingivitis during pregnancy and post-partum.
One hundred forty pregnant women 3 months gestation were enrolled in a 9 month, double-blind clinical study to evaluate the effect of 0.3% triclosan/copolymer dentifrice on gingivitis, compared to a placebo dentifrice. Women were stratified into two balanced groups according to their baseline gingivitis scores. They then received oral prophylaxis and were assigned to use either a placebo or the triclosan dentifrice for the next 9 months. The 3, 5 and 9 month results of this study showed that the triclosan dentifrice provided statistically significant reductions in gingivitis of 19.73, 27.91and 38.45%, respectively, compared to the placebo dentifrice.
Kraivaphan
Petcharat
P
Department of Pharmacology, Faculty of Dentistry, Mahidol University, Bangkok, Thailand.
Amornchat
Cholticha
C
Triratana
Terdphong
T
Leethochawalit
Ungkana
U
D000328:Adult; D003802:Dentifrices; D004311:Double-Blind Method; D005260:Female; D005891:Gingivitis / Q000188:drug therapy*; D006801:Humans; D011247:Pregnancy; D013785:Thailand; D013997:Time Factors; D014260:Triclosan / Q000627:therapeutic use*
D003802:Dentifrices; D014260:Triclosan