title: Preparation and biological studies of 125I-DOTA-TATE.
abstract: DOTA-TATE, a somatostatin analog was radiolabeled with (125)I in good yields and high radiochemical purity. The product exhibited good stability in vitro. Pharmacokinetic studies in normal Swiss mice showed rapid blood clearance with low thyroid uptake. Biodistribution studies in murine melanoma showed 3.0+/-1.3% ID/g uptake in tumor at 3h post injection (p.i.), with negligible reduction at 24h p.i. Inhibition studies carried out in vivo using cold DOTA-TATE confirmed the tumor specificity of the product.
authors.affiliation: Radiopharmaceuticals Division, Bhabha Atomic Research Centre, Mumbai 400 085, India.
authors.forename: Aruna
authors.initials: A
authors.lastname: Korde
authors.forename: Usha
authors.initials: U
authors.lastname: Pandey
authors.forename: Sharmila
authors.initials: S
authors.lastname: Banerjee
authors.forename: Haladhar
authors.initials: H
authors.lastname: Dev Sarma
authors.forename: Archana
authors.initials: A
authors.lastname: Mukherjee
authors.forename: Meera
authors.initials: M
authors.lastname: Venkatesh
mesh_terms: D000818:Animals; D004355:Drug Stability; D066298:In Vitro Techniques; D007457:Iodine Radioisotopes / Q000737:chemistry* / Q000493:pharmacokinetics; D008546:Melanoma, Experimental / Q000000981:diagnostic imaging; D051379:Mice; D008810:Mice, Inbred C57BL; D015282:Octreotide / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000493:pharmacokinetics; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D014018:Tissue Distribution
chemical_list: D007457:Iodine Radioisotopes; D019275:Radiopharmaceuticals; D015282:Octreotide