title: SEPPIC vaccine adjuvants for poultry.
abstract: Two inactivated antigens (Newcastle and Pasteurella Multocida) were formulated with different adjuvants and tested in two separate experiments in poultry. Oil formulations constituting water in oil (W/O) or water in oil in water (W/O/W) emulsions were assessed for antibody response, protection, local reactions, and vaccine physicochemical parameters. Robust, efficacious, and safe formulations were obtained with W/O formulations whereas W/O/W was especially safe with maintained efficacy. Results show that it is possible to improve traditional Tween Span formulations for safety and efficacy parameters by using Montanide ISA 70 for W/O formulations and Montanide ISA 206 for W/O/W when safety is the priority.
authors.affiliation: SEPPIC, 75 quai d'Orsay, 75321 Paris, Cedex 07, France. laurent.dupuis@airliquide.com
authors.forename: L
authors.initials: L
authors.lastname: Dupuis
authors.forename: S
authors.initials: S
authors.lastname: Ascarateil
authors.forename: J
authors.initials: J
authors.lastname: Aucouturier
authors.forename: V
authors.initials: V
authors.lastname: Ganne
mesh_terms: D000276:Adjuvants, Immunologic; D000818:Animals; D001428:Bacterial Vaccines / Q000276:immunology; D002645:Chickens; D004655:Emulsions; D009521:Newcastle Disease / Q000517:prevention & control*; D009522:Newcastle disease virus / Q000276:immunology*; D009821:Oils / Q000737:chemistry; D010326:Pasteurella Infections / Q000517:prevention & control / Q000662:veterinary*; D016979:Pasteurella multocida / Q000276:immunology*; D011201:Poultry Diseases / Q000517:prevention & control*; D012449:Safety; D016896:Treatment Outcome; D014611:Vaccination; D014765:Viral Vaccines / Q000276:immunology; D014867:Water / Q000737:chemistry
chemical_list: D000276:Adjuvants, Immunologic; D001428:Bacterial Vaccines; D004655:Emulsions; D009821:Oils; D014765:Viral Vaccines; D014867:Water