title: In vitro antimicrobial activity of Zingiber cassumunar (Plai) oil and a 5% Plai oil gel.
abstract: The essential oil of Zingiber cassumunar (Plai oil) exhibits antimicrobial activity against a wide range of Gram-positive and Gram-negative bacteria, dermatophytes and yeasts. Dermatophytes were found to be the most susceptible microorganisms followed by yeasts, whereas bacteria were the least susceptible. The mean diameter of the inhibition zone determined by the disc diffusion screening method increased with increasing Plai oil concentration between 6.25 and 50 vol %. The minimum bactericidal concentration (MBC) determined by the broth macrodilution method ranged from 0.62 to 2.5 vol % for Plai oil and from 52 to 79 mg/mL for the 5 wt % Plai oil gel, whereas the minimum fungicidal concentration (MFC) ranged from 0.31 to 1.25 vol % for Plai oil and from 13.8 to 39.5 mg/mL for the 5% Plai oil gel.
authors.affiliation: Department of Pharmacy, Faculty of Pharmacy, Mahidol University, Bangkok 10400, Thailand. pypph@mahidol.ac.th
authors.forename: P
authors.initials: P
authors.lastname: Pithayanukul
authors.forename: J
authors.initials: J
authors.lastname: Tubprasert
authors.forename: M
authors.initials: M
authors.lastname: Wuthi-Udomlert
mesh_terms: D000890:Anti-Infective Agents / Q000302:isolation & purification / Q000494:pharmacology*; D003883:Arthrodermataceae / Q000187:drug effects; D001419:Bacteria / Q000187:drug effects; D005782:Gels; D008826:Microbial Sensitivity Tests; D009822:Oils, Volatile / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D013729:Terpenes / Q000302:isolation & purification / Q000494:pharmacology; D015003:Yeasts / Q000187:drug effects; D030521:Zingiberaceae / Q000737:chemistry*
chemical_list: D000890:Anti-Infective Agents; D005782:Gels; D009822:Oils, Volatile; D013729:Terpenes; C034019:terpinenol-4