Regular exercise attenuated lipid peroxidation in adolescents with Down's syndrome.
OBJECTIVE
This study was designed to ascertain whether regular exercise may attenuate lipid peroxidation in adolescents with Down's syndrome.


METHODS
Thirty-one male adolescents with Down's syndrome performed a 12-week training program, 3 days/week at a work intensity of 60-75% of peak heart rate (HRmax=194.5-[0.56 age]). Plasmatic malondialdehyde (MDA) was determined by high performance liquid chromatography (HPLC).


RESULTS
When compared to baseline, MDA content was decreased significantly.


CONCLUSIONS
Regular exercise significantly decreased lipoperoxidation in Down's syndrome.
Javier Ordonez
Francisco
F
Sport Medicine School, Virgen del Saliente s/n, 11100 San Fernando, Cádiz, Spain.
Rosety-Rodriguez
Manuel
M
D000293:Adolescent; D004314:Down Syndrome / Q000097:blood / Q000378:metabolism*; D015444:Exercise / Q000502:physiology*; D006801:Humans; D015227:Lipid Peroxidation; D008297:Male; D008315:Malondialdehyde / Q000097:blood
D008315:Malondialdehyde