Mitochondrial toxins and neurodegenerative diseases.
The selective loss of a particular subset of neurons is a common feature of neurodegenerative disorders. A failure in respiratory chain complex activities in mitochondria seems to be a causative factor. The aim of this review is to describe the most important toxins affecting the mitochondrial function, which could be involved in the incidence of some of these diseases: MPTP, rotenone and 3-nitropropionic (3-NPA).
Ayala
Antonio
A
Departamento de Bioquimica, Bromatologia, Toxicologia y Medicina Legal, Facultad de Farmacia University of Seville, Spain.
Venero
Jose L
JL
Cano
Josefina
J
Machado
Alberto
A
D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D006816:Huntington Disease / Q000139:chemically induced; D020267:MPTP Poisoning / Q000139:chemically induced*; D008928:Mitochondria / Q000187:drug effects*; D019636:Neurodegenerative Diseases / Q000139:chemically induced*; D009574:Nitro Compounds / Q000633:toxicity*; D010302:Parkinson Disease, Secondary / Q000139:chemically induced; D011422:Propionates / Q000633:toxicity*; D012402:Rotenone / Q000633:toxicity*; D013385:Succinate Dehydrogenase / Q000037:antagonists & inhibitors; D044005:Tetrahydroisoquinolines / Q000737:chemistry / Q000378:metabolism
D009574:Nitro Compounds; D011422:Propionates; D044005:Tetrahydroisoquinolines; D012402:Rotenone; D013385:Succinate Dehydrogenase; C015392:3-nitropropionic acid