Impact of transporter-mediated drug absorption, distribution, elimination and drug interactions in antimicrobial chemotherapy.
A comprehensive list of drug transporters has recently become available as a result of extensive genome analysis. Membrane transporters play important roles in determining the pharmacokinetic aspects of intestinal absorption, tissue distribution, and the urinary and biliary excretions of a wide variety of therapeutic drugs. The identification and characterization of transporters responsible for the transfer of nutrients and xenobiotics, including drugs, is expected to provide a scientific basis for understanding drug disposition, as well as the molecular mechanisms of drug-drug/drug-food/drug-protein interactions and inter-individual/inter-species differences. This review focuses on the influence of transporters on the pharmacokinetics of beta-lactam antibiotics, new quinolones, and other antimicrobial agents, as well as focusing on the drug-drug interactions associated with transporter-mediated uptake from the small intestine and transporter-mediated elimination from the kidney and liver.
Tsuji
Akira
A
Department of Molecular Pharmaceutics, Graduate School of Natural Science and Technology, Kanazawa University, Kanazawa, Japan. tsuji@kenroku.kanazawa-u.ac.jp
D000818:Animals; D000890:Anti-Infective Agents / Q000493:pharmacokinetics* / Q000494:pharmacology; D001692:Biological Transport; D004347:Drug Interactions; D006801:Humans; D007408:Intestinal Absorption; D026901:Membrane Transport Proteins / Q000378:metabolism*; D015363:Quinolones / Q000493:pharmacokinetics; D012293:Rifampin / Q000493:pharmacokinetics; D014018:Tissue Distribution; D047090:beta-Lactams / Q000493:pharmacokinetics
D000890:Anti-Infective Agents; D026901:Membrane Transport Proteins; D015363:Quinolones; D047090:beta-Lactams; D012293:Rifampin