title: Pseudo-Pelger-Huët in kidney-transplanted patients.
abstract: Pelger-Huët anomaly is an inherited condition characterized by hyposegmentation of the neutrophil nucleus and excessive chromatin clumping. Acquired Pelger-Huët, also known as pseudo-Pelger-Huët, has been described in several clinical conditions including transplant recipients who received immunosuppressive drugs. The incidence of pseudo-Pelger-Huët in kidney transplant patients, characterized as neutrophil dysplasia, was observed in 9 of 170 patients (5.3%) at the São Francisco Hospital de Assis, Belo Horizonte, Brazil. Awareness of possible circulating neutrophil alterations in transplant patients is important for laboratory professionals who should report these findings of cell changes. It should be highlighted that the poor segmentation and the chromatin hypercondensation observed initially in pseudo-Pelger-Huët patients can be suggestive of early-stage neutrophils. Only a combination of laboratory and clinical data will facilitate a better understanding of this anomaly and its correct follow-up and management.
authors.affiliation: Faculty of Pharmacy, Federal University of Minas Gerais, Belo Horizonte, Brazil. lucim@farmacia.ufmg.br
authors.forename: Luci Maria Sant'Ana
authors.initials: LM
authors.lastname: Dusse
authors.forename: Rívia Mara
authors.initials: RM
authors.lastname: Morais E Silva
authors.forename: Vânia Maria
authors.initials: VM
authors.lastname: Freitas
authors.forename: Geraldo Majella
authors.initials: GM
authors.lastname: Medeiros de Paula
authors.forename: Lauro Mello
authors.initials: LM
authors.lastname: Vieira
authors.forename: Maria das Graças
authors.initials: Md
authors.lastname: Carvalho
mesh_terms: D042002:Chromatin Assembly and Disassembly; D003937:Diagnosis, Differential; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects; D015994:Incidence; D016030:Kidney Transplantation / Q000009:adverse effects*; D009504:Neutrophils / Q000473:pathology*; D010381:Pelger-Huet Anomaly / Q000453:epidemiology / Q000209:etiology* / Q000473:pathology*
chemical_list: D007166:Immunosuppressive Agents