title: Baló's encephalitis periaxialis concentrica.
abstract: In 1928, Baló described a law student with an unusual fatal illness marked by aphasia and a right hemiplegia, with later optic neuritis and normal cerebrospinal fluid. At autopsy, he found a disease of the white matter characterised by foci varying in size from a lentil to that of a pigeon's egg and presenting gray softening and, in part, concentricity, where the medullary sheaths were destroyed and the axis cylinders were intact. He was uncertain whether this was a variant of acute multiple sclerosis or of Schilder's disease. The basis of concentric sclerosis is still unclear though current opinion favours a variant of acute multiple sclerosis.
authors.affiliation: Department of Neurology, Hull Royal Infirmary, Hull, UK.
authors.forename: J M S
authors.initials: JM
authors.lastname: Pearce
mesh_terms: D000328:Adult; D003937:Diagnosis, Differential; D004660:Encephalitis / Q000145:classification* / Q000473:pathology*; D049673:History, 20th Century; D006801:Humans; D008297:Male; D009103:Multiple Sclerosis / Q000473:pathology*; D009462:Neurology / Q000266:history