title: Enterostomy tube placement in children with spinal muscular atrophy type 1.
abstract: OBJECTIVE
  To determine the major complication rate in the first 30 days after enterostomy tube insertion in infants with spinal muscular atrophy (SMA) type 1.
  
  
  METHODS
  A retrospective case review of all children with SMA type 1 who had a gastrostomy or gastrojejunostomy tube placed by the image-guided technique at the Hospital for Sick Children from 1994-2004. Major complications were classified as peritonitis, aspiration pneumonia, respiratory failure, nonelective admission to the pediatric intensive care unit, and death.
  
  
  RESULTS
  Twelve children were identified as having SMA type 1 with an enterostomy tube insertion. The median age at tube insertion was 6.1 months (range 2.2 to 15.8 months). Major complications in the first 30 days after the procedure included aspiration pneumonia (5/12 patients [41.6%]), respiratory failure requiring admission to the pediatric intensive care unit (4/12 [33%]), and death (2/12 [16.7%]). Children with development of aspiration pneumonia were significantly older at time of tube insertion (P < .05) than those with no aspiration.
  
  
  CONCLUSIONS
  Major complications including death are seen in children with SMA type 1 in the first 30 days after enterostomy tube insertion.
authors.affiliation: Division of Paediatric Medicine and Paediatric Outcomes Research Team, the Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Ontario, Canada.
authors.forename: K
authors.initials: K
authors.lastname: Sy
authors.forename: S
authors.initials: S
authors.lastname: Mahant
authors.forename: N
authors.initials: N
authors.lastname: Taback
authors.forename: J
authors.initials: J
authors.lastname: Vajsar
authors.forename: P G
authors.initials: PG
authors.lastname: Chait
authors.forename: J N
authors.initials: JN
authors.lastname: Friedman
mesh_terms: D004750:Enteral Nutrition / Q000009:adverse effects* / Q000295:instrumentation*; D004766:Enterostomy / Q000009:adverse effects* / Q000295:instrumentation*; D006801:Humans; D007223:Infant; D011183:Postoperative Complications / Q000453:epidemiology; D012189:Retrospective Studies; D014897:Spinal Muscular Atrophies of Childhood / Q000628:therapy