Clinical manifestations of hemoglobin Chico at high altitude.
Hemoglobin Chico is a rare hemoglobinopathy characterized by low oxygen affinity and a right-shifted oxygen dissociation curve. Detailed clinical evaluations of affected individuals have not been previously reported. We therefore report on the clinical features of Hemoglobin Chico in a Latino male living at high altitude, who desired to participate in school sports. As a young boy with asthma, he had the unusual finding of growth delay and digital clubbing which improved with asthma control. At 16 years of age, he had mild anemia and a decreased pulse oximetry (83%) but sufficient pulmonary reserve to participate in physically demanding activities.
Starkey
Cindi R
CR
Department of Pathology, The University of New Mexico, Albuquerque, NM, USA.
Davies
Lea
L
Hoyer
James D
JD
Wilson
Carla S
CS
Winter
Stuart S
SS
D000293:Adolescent; D000531:Altitude; D000740:Anemia / Q000209:etiology; D001249:Asthma / Q000150:complications; D006453:Hemoglobinopathies / Q000175:diagnosis*; D006455:Hemoglobins, Abnormal; D006801:Humans; D008297:Male; D010092:Oximetry
D006455:Hemoglobins, Abnormal; C054742:hemoglobin Chico