title: Extended longevity mechanisms in short-lived progeroid mice: identification of a preservative stress response associated with successful aging.
abstract: Semantic distinctions between "normal" aging, "pathological" aging (or age-related disease) and "premature" aging (otherwise known as segmental progeria) potentially confound important insights into the nature of each of the complex processes. Here we review a recent, unexpected discovery: the presence of longevity-associated characteristics typical of long-lived endocrine-mutant and dietary-restricted animals in short-lived progeroid mice. These data suggest that a subset of symptoms observed in premature aging, and possibly normal aging as well, may be indirect manifestations of a beneficial adaptive stress response to endogenous oxidative damage, rather than a detrimental result of the damage itself.
authors.affiliation: Medical Genetics Center, Department of Cell Biology and Genetics, Center of Biomedical Genetics, P.O. Box 1738, Erasmus MC, 3000DR Rotterdam, The Netherlands.
authors.forename: Marieke
authors.initials: M
authors.lastname: van de Ven
authors.forename: Jaan-Olle
authors.initials: JO
authors.lastname: Andressoo
authors.forename: Valerie B
authors.initials: VB
authors.lastname: Holcomb
authors.forename: Paul
authors.initials: P
authors.lastname: Hasty
authors.forename: Yousin
authors.initials: Y
authors.lastname: Suh
authors.forename: Harry
authors.initials: H
authors.lastname: van Steeg
authors.forename: George A
authors.initials: GA
authors.lastname: Garinis
authors.forename: Jan H J
authors.initials: JH
authors.lastname: Hoeijmakers
authors.forename: James R
authors.initials: JR
authors.lastname: Mitchell
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D004260:DNA Repair / Q000502:physiology; D008136:Longevity / Q000502:physiology*; D051379:Mice; D011371:Progeria / Q000503:physiopathology*; D013312:Stress, Physiological / Q000503:physiopathology*