Comment on papers by Chong et al., Nishio et al., and Suri et al. on diabetes reversal in NOD mice.
Chong et al., Nishio et al., and Suri et al. (Reports, 24 March 2006, pp. 1774, 1775, and 1778) confirmed that treating nonobese diabetic (NOD) mice with an immune adjuvant and semisyngenic spleen cells can reverse the disease but found that spleen cells did not contribute to the observed recovery of pancreatic islets. We show that islet regeneration predominately originates from endogenous cells but that introduced spleen cells can also contribute to islet recovery.
Faustman
Denise L
DL
Massachusetts General Hospital, Charlestown, MA 02129, USA. faustman@helix.mgh.harvard.edu
Tran
Simon D
SD
Kodama
Shohta
S
Lodde
Beatrijs M
BM
Szalayova
Ildiko
I
Key
Sharon
S
Toth
Zsuzsanna E
ZE
Mezey
Eva
E
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D002454:Cell Differentiation; D017690:Cell Transplantation; D003131:Combined Modality Therapy; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology / Q000628:therapy*; D005260:Female; D005620:Freund's Adjuvant / Q000627:therapeutic use*; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D050417:Insulin-Secreting Cells / Q000166:cytology* / Q000378:metabolism; D007515:Islets of Langerhans / Q000166:cytology*; D016381:Islets of Langerhans Transplantation; D008297:Male; D051379:Mice; D016688:Mice, Inbred NOD; D012038:Regeneration; D013154:Spleen / Q000166:cytology*
D001786:Blood Glucose; D007328:Insulin; D005620:Freund's Adjuvant