How many drug targets are there?
For the past decade, the number of molecular targets for approved drugs has been debated. Here, we reconcile apparently contradictory previous reports into a comprehensive survey, and propose a consensus number of current drug targets for all classes of approved therapeutic drugs. One striking feature is the relatively constant historical rate of target innovation (the rate at which drugs against new targets are launched); however, the rate of developing drugs against new families is significantly lower. The recent approval of drugs that target protein kinases highlights two additional trends: an emerging realization of the importance of polypharmacology, and also the power of a gene-family-led approach in generating novel and important therapies.
Overington
John P
JP
Inpharmatica Ltd., 1 New Oxford Street, London, WC1A 1NU, UK. j.overington@inpharmatica.co.uk
Al-Lazikani
Bissan
B
Hopkins
Andrew L
AL
D017277:Drug Approval; D016503:Drug Delivery Systems / Q000639:trends*; D015195:Drug Design; D015507:Drugs, Investigational / Q000627:therapeutic use*; D015894:Genome, Human; D006801:Humans; D013678:Technology, Pharmaceutical
D015507:Drugs, Investigational