Changes of plasma asymmetric dimethylarginine levels after coronary artery bypass grafting.
OBJECTIVE
We investigated whether coronary artery bypass grafting affects plasma asymmetric dimethylarginine (ADMA) concentrations and whether precardioplegic hyperoxia influences ADMA release from the heart.


METHODS
Twenty two patients were randomized into control (n = 11) and hyperoxia (n = 11, ventilated with >96% oxygen before cardiopulmonary bypass) groups. Arterial and coronary sinus blood was sampled before cardioplegia and during early reperfusion. Arterial samples were drawn 60 min after declamping of the aorta, and on the first postoperative day.


RESULTS
Baseline arterial values of ADMA were not different between groups (0.59+/-0.18 micro mol/l control, 0.63+/-0.13 micro mol/l hyperoxia group). Negligible release of ADMA into coronary sinus was detected 20 min after cardioplegia. A significant decrease of arterial ADMA was observed by the first postoperative morning (0.42+/-0.16 micro mol/l in control, and 0.38+/-0.07 in hyperoxia group, p < 0.01 compared to baseline).


CONCLUSIONS
CABG with cardioplegia is associated with decrease of ADMA by the first postoperative morning. Reperfusion of cardioplegic heart did not result in significant release of ADMA. Pretreatment with hyperoxia had no influence on myocardial release and arterial levels of ADMA.
Karu
Inga
I
Institute of Biochemistry, University of Tartu, Estonia. inga@mini.li.ttu.ee
Zilmer
Kersti
K
Starkopf
Joel
J
Zilmer
Mihkel
M
D001120:Arginine / Q000031:analogs & derivatives* / Q000097:blood / Q000378:metabolism; D002315:Cardiopulmonary Bypass; D001026:Coronary Artery Bypass / Q000379:methods; D003327:Coronary Disease / Q000097:blood* / Q000378:metabolism / Q000601:surgery*; D005260:Female; D006324:Heart Arrest, Induced; D006801:Humans; D018496:Hyperoxia / Q000097:blood; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism; D011184:Postoperative Period; D013997:Time Factors
C018524:N,N-dimethylarginine; D001120:Arginine