title: Amniocentesis results and novel proteomic analysis in a case of occult candidal chorioamnionitis.
abstract: We report a case of subclinical Candida albicans chorioamnionitis with mid-trimester cervical dilation diagnosed by amniotic fluid culture and Gram stain. Proteomic analysis of amniotic fluid demonstrated protein biomarkers previously associated only with bacterial intra-amniotic infections. We hypothesize that since amniotic fluid culture of yeast may take days, novel tests such as proteomic profiling may lead to the development of rapid diagnostic tests for fungal intra-amniotic infections.
authors.affiliation: Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, OR, USA. crawforj@ohsu.edu
authors.forename: Julie T
authors.initials: JT
authors.lastname: Crawford
authors.forename: Leonardo
authors.initials: L
authors.lastname: Pereira
authors.forename: John
authors.initials: J
authors.lastname: Buckmaster
authors.forename: Michael G
authors.initials: MG
authors.lastname: Gravett
authors.forename: Jorge E
authors.initials: JE
authors.lastname: Tolosa
mesh_terms: D000328:Adult; D000649:Amniocentesis; D000935:Antifungal Agents / Q000627:therapeutic use; D002177:Candidiasis / Q000175:diagnosis* / Q000188:drug therapy / Q000378:metabolism*; D002821:Chorioamnionitis / Q000175:diagnosis* / Q000188:drug therapy / Q000378:metabolism / Q000382:microbiology*; D005260:Female; D015725:Fluconazole / Q000627:therapeutic use; D006801:Humans; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000175:diagnosis* / Q000188:drug therapy; D011264:Pregnancy Trimesters; D040901:Proteomics
chemical_list: D000935:Antifungal Agents; D015725:Fluconazole