title: Results of the national survey of borderline ovarian tumors in Spain.
abstract: METHODS
  Retrospective multi-center analysis of women diagnosed with borderline ovarian tumor and treated between January 1990 and December 1997. A national survey was conducted, in which 457 patients from 27 centers corresponding to ten of Spain's autonomous communities were analyzed.
  
  
  RESULTS
  Four hundred fifty-seven women with borderline ovarian tumor were analyzed. The mean age of patients was 45.5+/-16.9 years. Of these, 390 patients (85.3%) were at stage I, 8 (1.8%) were at stage II and 36 (7.9%) at stage III. A bilateral tumor was observed in 63 women (13.8%). The mean tumor size was 14.2 cm and in 88 cases (19.3%) the tumor was on the surface of the ovary. Microinvasion was observed in 25 (5.5%) cases, and 29 women (6.3%) showed a micropapillary pattern. Study of the factors related to the appearance of peritoneal implants revealed positive tumor markers (OR 15.02: 1.9-32.9) and a tumor on the ovarian surface (OR 8.0: 1.8-127) to be independent risk factors. With respect to recurrence, the presence of peritoneal implants at the time of initial surgery (OR 3.4: 1.1-10.4) and signs of microinvasion in the anatomicopathological study (OR 5.5: 1.5-17.8) were found to be independent risk factors. The overall survival rate in our series was 97% with a mean follow-up of 88.3 months. The survival rate by stage was 97% for stage I, 100% for stage II and 97% for stage III.
  
  
  CONCLUSIONS
  Although borderline ovarian tumors have an excellent prognosis, they are not exempt from a risk of recurrence. Characterization of patients with borderline ovarian tumor is essential in order to prevent their evolution. Likewise, the taking on board of risk factors will enable more selective treatments to be offered in each case.
authors.affiliation: Institut Universitari Dexeus, Pso. Bonanova 67, 08017 Barcelona, Spain. maicus@dexeus.com
authors.forename: Maite
authors.initials: M
authors.lastname: Cusidó
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Balagueró
authors.forename: Gines
authors.initials: G
authors.lastname: Hernandez
authors.forename: Orlando
authors.initials: O
authors.lastname: Falcón
authors.forename: Francisco José
authors.initials: FJ
authors.lastname: Rodríguez-Escudero
authors.forename: José Antonio
authors.initials: JA
authors.lastname: Vargas
authors.forename: José Antonio
authors.initials: JA
authors.lastname: Vidart
authors.forename: L
authors.initials: L
authors.lastname: Zamora
authors.forename: M
authors.initials: M
authors.lastname: Monera
authors.forename: Asunción
authors.initials: A
authors.lastname: Alonso
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D010051:Ovarian Neoplasms / Q000453:epidemiology / Q000473:pathology* / Q000601:surgery; D012189:Retrospective Studies; D013030:Spain / Q000453:epidemiology