title: Use of bi-allelic insertion/deletion polymorphisms as a positive control for fetal genotyping in maternal blood: first clinical experience.
abstract: Amplification of fetal DNA in maternal plasma is a new way for non-invasive fetal genotyping in pregnancies at risk for disorders where the presence of a paternal DNA sequence contributes to the risk status of the fetus. We describe the use of a panel of 10 bi-allelic highly polymorphic markers to ascertain the presence and amplification of fetal DNA in case the fetus is negative for the targeted paternal "disease" sequence.
authors.affiliation: Division of Perinatology and Gynecology, University Medical Centre, P.B. 85090, 3508 AB Utrecht, the Netherlands. l.christiaens@umcutrecht.nl
authors.forename: Godelieve C M L
authors.initials: GC
authors.lastname: Page-Christiaens
authors.forename: Bernadette
authors.initials: B
authors.lastname: Bossers
authors.forename: C Ellen
authors.initials: CE
authors.lastname: VAN DER Schoot
authors.forename: Masja
authors.initials: M
authors.lastname: DE Haas
mesh_terms: D000483:Alleles; D004247:DNA / Q000097:blood*; D005260:Female; D005333:Fetus / Q000502:physiology*; D017353:Gene Deletion; D005819:Genetic Markers; D005838:Genotype; D006801:Humans; D008297:Male; D008431:Maternal-Fetal Exchange; D011110:Polymorphism, Genetic; D011247:Pregnancy; D011296:Prenatal Diagnosis; D012204:Rh-Hr Blood-Group System / Q000235:genetics
chemical_list: D005819:Genetic Markers; D012204:Rh-Hr Blood-Group System; C026410:Rho(D) antigen; D004247:DNA