Ovarian tissue cryostorage and grafting: an option to preserve fertility in pediatric patients with malignancies.
Fertility preservation in childhood cancer has become an important area of investigation due to increasing survival rates after cancer therapy. For these patients with an increased risk of infertility and premature ovarian failure, cryopreservation of ovarian tissue is a promising tool to preserve at least part of the reproductive potential. In recent years significant improvements have been achieved in this area, and 2 live births after autografting of frozen-thawed ovarian tissue have been reported. However, further research is needed to assess the clinical effectiveness of ovarian cryopreservation, to optimize the technique, and to limit the risk of reintroducing cancer cells in the patient with the graft.
Moffa
Federica
F
Reproductive Medicine and IVF Unit, Department of Gynaecological and Obstetrical Sciences, University of Turin, OIRM-S., Anna Hospital, Turin, Italy.
Biacchiardi
Chiara Perono
CP
Fagioli
Franca
F
Biasin
Eleonora
E
Revelli
Alberto
A
Massobrio
Marco
M
Madon
Enrico
E
D000293:Adolescent; D000970:Antineoplastic Agents / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D015925:Cryopreservation / Q000941:ethics; D005260:Female; D006801:Humans; D007223:Infant; D007247:Infertility, Female / Q000209:etiology / Q000517:prevention & control*; D009369:Neoplasms / Q000628:therapy; D010053:Ovary / Q000637:transplantation*; D016649:Primary Ovarian Insufficiency / Q000209:etiology / Q000628:therapy; D011878:Radiotherapy / Q000009:adverse effects*; D027724:Reproductive Techniques, Assisted; D016378:Tissue Transplantation / Q000941:ethics
D000970:Antineoplastic Agents