Preparation and characterization of pH sensitive comb-shaped chitosan material for the controlled release of coenzyme A.
A novel kind of pH sensitive comb-shaped copolymer P(CS-Ma-PEGMA) was synthesized with chitosan (CS), maleic anhydride (Ma) and Poly (ethylene glycol) methacrylate (PEGMA) by grafting and co-polymerization. The structure of P(CS-Ma-PEGMA) was characterized by FT-IR and (1)H-NMR, and it was found that PEGMA was grafted onto CS and PEGMAylated chitosan was soluble. The copolymer was subjected to coenzyme A adsorption study in order to assess its application in biomedical area. The factors affecting release behavior, such as concentration and pH were discussed in this paper. The higher concentration of the copolymer showed higher absorbance peak than the lower one. The pH of the solution also had significant impact on the release of coenzyme A, and the mechanism of adsorption was suggested. The results suggested that the novel copolymer could be used as drug delivery carrier.
Guo
Baolin
B
Institute of Fine Chemical and Engineering, Henan University, Kaifeng, Henan, PR China.
Yuan
Jinfang
J
Gao
Qingyu
Q
D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry / Q000302:isolation & purification*; D048271:Chitosan / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification*; D003065:Coenzyme A / Q000008:administration & dosage*; D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000737:chemistry / Q000302:isolation & purification; D016503:Drug Delivery Systems; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D008299:Maleic Anhydrides / Q000737:chemistry; D008422:Materials Testing; D011092:Polyethylene Glycols / Q000737:chemistry; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared
D001672:Biocompatible Materials; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D008299:Maleic Anhydrides; C450003:poly(ethylene glycol) methacrylate polymer; D011092:Polyethylene Glycols; D048271:Chitosan; D003065:Coenzyme A