Metal chelators react also with reactive oxygen and nitrogen species.
Popular chelators (desferrioxamine, SIH, EDTA, EGTA, DTPA, and NTA) were demonstrated to have antioxidant properties, being able to reduce ABTS radical cation and react with peroxyl radicals, peroxynitrite, and hypochlorite. Desferrioxamine and SIH were most potent antioxidants in all cases. These results point to the necessity of a careful interpretation of experiments in which the inhibition of free radical reactions by antioxidants is used as a proof of involvement of metal ions in a reaction.
Balcerczyk
Aneta
A
Department of Molecular Biophysics, University of Lodz, Banacha 12/16, 90-237 Lodz, Poland. abal@biol.uni.lodz.pl
Sowa
Katarzyna
K
Bartosz
Grzegorz
G
D002614:Chelating Agents / Q000737:chemistry*; D007700:Kinetics; D008670:Metals / Q000737:chemistry*; D010084:Oxidation-Reduction; D026361:Reactive Nitrogen Species / Q000737:chemistry*; D017382:Reactive Oxygen Species / Q000737:chemistry*
D002614:Chelating Agents; D008670:Metals; D026361:Reactive Nitrogen Species; D017382:Reactive Oxygen Species