Overt diabetes mellitus in a patient with combined primary aldosteronism and Cushing's syndrome.
Although there are some case reports of combined aldosterone and cortisol producing adrenal tumor, overt diabetes mellitus has been rarely described. A 55-year-old hypertensive woman had hypokalemia and overt hyperglycemia without Cushingoid clinical features. The body mass index was 18.2 kg/m2, fasting blood glucose was 302 mg/dl and hemoglobin A1c was 11.6%. Endogenous insulin secretion was well preserved, whereas insulin sensitivity measured by short insulin tolerance test was markedly impaired. A solitary left aldosterone- and cortisol-producing adrenal tumor was diagnosed. We described a rare case of overt diabetes mellitus in a patient with combined primary aldosteronism and Cushing's syndrome.
Sasaki
Nobuhiro
N
Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka.
Iwase
Masanori
M
Arima
Hisatomi
H
Nohara
Sakae
S
Bandai
Sachiko
S
Yao
Takashi
T
Fujii
Koji
K
Iida
Mitsuo
M
D000310:Adrenal Gland Neoplasms / Q000150:complications / Q000175:diagnosis / Q000601:surgery; D003480:Cushing Syndrome / Q000150:complications / Q000175:diagnosis* / Q000601:surgery; D048909:Diabetes Complications / Q000150:complications / Q000175:diagnosis / Q000601:surgery; D003920:Diabetes Mellitus / Q000175:diagnosis* / Q000601:surgery; D005260:Female; D006801:Humans; D006929:Hyperaldosteronism / Q000150:complications / Q000175:diagnosis* / Q000601:surgery; D008875:Middle Aged