Relationship between 1,25-dihydroxycholecalciferol levels and functional outcome after hip fracture in elderly patients.
A prospective study was performed in 109 patients with osteoporotic hip fracture to verify the relationship between 1,25-dihydroxycholecalciferol levels at admission and functional recovery in elderly patients with hip fracture. 47.7% of all the patients had 1,25-dihydroxycholecalciferol levels below the reference values of our laboratory. At 1 year of the fracture only 33 patients (30.3%) had recovered the functional level they had before the fracture. In the bivariate analysis, a statistically significant relationship was found between reduced 1,25-dihydroxycholecalciferol levels and a poorer functional recovery 1 year after the fracture was sustained. A multivariate analysis showed a significant relationship between 1,25-dihydroxycholecalciferol levels and absolute dependence of the patient 1 year after the fracture (P = 0.005; OR 6.97: CI- 1.77-27.41).
Carpintero
Pedro
P
Orthopaedics Department, University Hospital Reina Sofia, Avenida Menendez-Pidal S/N, 14004 Cordoba, Spain. pcarpinterob@medynet.com
Garcia-Lazaro
Milagros
M
Montero
Manuel
M
Lopez-Castro
Pedro
P
León
Francisco
F
Aguilera
Critobal
C
D000058:Accidental Falls; D000203:Activities of Daily Living; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D002117:Calcitriol / Q000097:blood*; D005260:Female; D006620:Hip Fractures / Q000097:blood* / Q000209:etiology / Q000503:physiopathology; D006801:Humans; D016015:Logistic Models; D008297:Male; D015999:Multivariate Analysis; D010024:Osteoporosis / Q000097:blood* / Q000150:complications / Q000503:physiopathology; D011446:Prospective Studies; D020127:Recovery of Function
D015415:Biomarkers; D002117:Calcitriol