title: Computer-aided detection in digital mammography: comparison of craniocaudal, mediolateral oblique, and mediolateral views.
abstract: OBJECTIVE
  To retrospectively compare the sensitivity of a computer-aided detection (CAD) system for depicting breast cancer in three digital mammographic views.
  
  
  METHODS
  This study was conducted with institutional review board approval; informed consent was waived. A commercially available CAD system was applied to the craniocaudal, mediolateral oblique, and mediolateral digital mammographic views of 83 women (mean age, 48 years; range, 30-66 years) with 83 histologically proved breast cancers. Findings were 59 masses and 41 microcalcifications (17 lesions showed both findings; 42 lesions, mass only; and 24 lesions, microcalcification only). The paired t test was used to analyze sensitivity of the CAD system for the detection of cancer in these three mammographic views and in combinations of the views.
  
  
  RESULTS
  The sensitivities of the CAD system were 92% (76 of 83) in the craniocaudal view, 83% (69 of 83) in the mediolateral oblique view, and 86% (71 of 83) in the mediolateral view; the differences were not significant (P = .07-.62). Sensitivity increased to 96% (80 of 83) in the craniocaudal plus mediolateral oblique views and to 99% (82 of 83) in the craniocaudal plus mediolateral oblique plus mediolateral views. For masses, the sensitivity of the CAD system was 76% (45 of 59) in the craniocaudal view and 75% (44 of 59) in the mediolateral oblique view and increased to 93% (55 of 59) when mediolateral oblique and craniocaudal views were combined (P < .001). For microcalcifications, sensitivity was 98% (40 of 41) in the craniocaudal view and 95% (39 of 41) in the mediolateral oblique view, and this increased to 100% (41 of 41) when the mediolateral oblique and craniocaudal views were combined (P = .31).
  
  
  CONCLUSIONS
  The sensitivities of the CAD system were not significantly different among these three digital mammographic views. Sensitivity for depicting masses was significantly increased (P < .001) when the craniocaudal view was added to the mediolateral oblique view.
authors.affiliation: Department of Radiology and Clinical Research Institute, Seoul National University Hospital and the Institute of Radiation Medicine, Seoul National University Medical Research Center, 28, Yongon-dong, Chongno-gu, Seoul, 100-744, Korea.
authors.forename: Seung Ja
authors.initials: SJ
authors.lastname: Kim
authors.forename: Woo Kyung
authors.initials: WK
authors.lastname: Moon
authors.forename: Nariya
authors.initials: N
authors.lastname: Cho
authors.forename: Joo Hee
authors.initials: JH
authors.lastname: Cha
authors.forename: Sun Mi
authors.initials: SM
authors.lastname: Kim
authors.forename: Jung-Gi
authors.initials: JG
authors.lastname: Im
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000000981:diagnostic imaging*; D005189:False Positive Reactions; D005260:Female; D006801:Humans; D008327:Mammography / Q000379:methods*; D008875:Middle Aged; D018579:Patient Selection; D011857:Radiographic Image Interpretation, Computer-Assisted; D012189:Retrospective Studies; D012680:Sensitivity and Specificity