title: Results of a whole-genome quantitative trait locus scan for growth, carcass composition and meat quality in a porcine four-way cross.
abstract: A whole-genome quantitative trait locus (QTL) scan for 31 phenotypes related to growth, carcass composition and meat quality was conducted using 1187 progeny of a commercial four-way cross. Animals were genotyped for 198 microsatellite markers that spanned the entire porcine genome. QTL analysis was conducted to extract information from paternal and maternal meioses separately using a rank-based nonparametric approach for half-sib designs. Nine QTL exceeded genome-wide significance: one QTL affecting growth (average daily gain on SSC1), two QTL influencing carcass composition (fatness on SSC3 and muscle mass on SSC15) and six QTL influencing meat quality (tenderness on SSC4 and SSC14; colour on SSC5, SSC6 and SSCX; and conductivity on SSC16). All but one of these coincided with previously reported QTL. In addition, we present evidence for 78 suggestive QTL with a combined false discovery rate of 40%.
authors.affiliation: Unit of Animal Genomics, Faculty of Veterinary Medicine and Centre for Biomedical Integrative Genoproteomics, 20 Boulevard de Colonster, 4000 Liège, Belgium.
authors.forename: N
authors.initials: N
authors.lastname: Harmegnies
authors.forename: F
authors.initials: F
authors.lastname: Davin
authors.forename: S
authors.initials: S
authors.lastname: De Smet
authors.forename: N
authors.initials: N
authors.lastname: Buys
authors.forename: M
authors.initials: M
authors.lastname: Georges
authors.forename: W
authors.initials: W
authors.lastname: Coppieters
mesh_terms: D000818:Animals; D001823:Body Composition / Q000235:genetics*; D002874:Chromosome Mapping; D033481:Chromosomes, Mammalian; D003433:Crosses, Genetic; D005260:Female; D016678:Genome; D006823:Hybrid Vigor / Q000235:genetics; D008297:Male; D008460:Meat; D010641:Phenotype; D040641:Quantitative Trait Loci; D034421:Sus scrofa / Q000235:genetics*