Use of calcined Mg-Al-hydrotalcite to enhance the stability of celecoxib in the amorphous form.
The use of compound in amorphous forms is a promising approach to improve solubility of poorly water-soluble drugs. However, during storage, amorphous state can spontaneously transform to the lower energy crystalline form and this is a limiting factor for a large commercial use of drugs. In this paper, calcined hydrotalcite was employed to support amorphous celecoxib and several preparations at different weight drug/carrier ratio were prepared. Solubility of celecoxib from the prepared systems was evaluated and its physical stability during storage at different conditions was examined as well. The results show that HTlc-calc can be used as a support of amorphous celecoxib with consequent improvement of drug solubility and physical stability.
Ambrogi
Valeria
V
Dipartimento di Chimica e Tecnologia del Farmaco, University of Perugia, Perugia, Italy. valeria.ambrogi@unipg.it
Perioli
Luana
L
Marmottini
Fabio
F
Rossi
Carlo
C
D000536:Aluminum Hydroxide / Q000737:chemistry*; D002152:Calorimetry, Differential Scanning; D000068579:Celecoxib; D002626:Chemistry, Pharmaceutical; D003460:Crystallization; D018360:Crystallography, X-Ray; D052246:Cyclooxygenase 2 Inhibitors / Q000737:chemistry*; D004355:Drug Stability; D004356:Drug Storage; D005079:Excipients / Q000737:chemistry*; D005240:Feasibility Studies; D008276:Magnesium Hydroxide / Q000737:chemistry*; D011720:Pyrazoles / Q000737:chemistry*; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared; D013449:Sulfonamides / Q000737:chemistry*; D013499:Surface Properties; D013678:Technology, Pharmaceutical / Q000379:methods; D013997:Time Factors
D052246:Cyclooxygenase 2 Inhibitors; D005079:Excipients; D011720:Pyrazoles; D013449:Sulfonamides; C010467:hydrotalcite; D000536:Aluminum Hydroxide; D000068579:Celecoxib; D008276:Magnesium Hydroxide