[Cell therapy as a method to correct pathogenetic disturbances in dyslipidemia and early atherosclerosis].
The article is dedicated to the pathogenetic mechanisms of the development of immune inflammation in the vascular wall, as well as hepatic functional disregulation in dislipidemia and atherosclerosis. The authors emphasize that the decompensation of the process of cell regeneration in actively functioning organs (vascular endothelium, hepatocytes) and a concomitant immune disregulation become the main factors of the progression of dislipidemia and atherosclerosis. The authors consider the conditions for and factors of cell therapy, based on the use of allogenic fetal hepatic cells and autological bone marrow cells.
Onishchenko
N A
NA
Klimenko
E D
ED
Pozdniakov
O M
OM
D000818:Animals; D050197:Atherosclerosis / Q000209:etiology / Q000276:immunology / Q000503:physiopathology / Q000628:therapy*; D001853:Bone Marrow; D001854:Bone Marrow Cells / Q000502:physiology; D016026:Bone Marrow Transplantation; D002478:Cells, Cultured; D004036:Diet, Atherogenic; D004195:Disease Models, Animal; D018450:Disease Progression; D050171:Dyslipidemias / Q000209:etiology / Q000276:immunology / Q000503:physiopathology / Q000628:therapy*; D004730:Endothelium, Vascular / Q000502:physiology / Q000503:physiopathology; D005500:Follow-Up Studies; D022781:Hepatocytes / Q000637:transplantation*; D006801:Humans; D008099:Liver / Q000196:embryology / Q000503:physiopathology; D008115:Liver Regeneration; D011817:Rabbits; D012038:Regeneration; D013997:Time Factors; D014184:Transplantation, Homologous