title: High levels of cervical HIV-1 RNA during early HIV-1 infection.
abstract: Few data are available on genital tract viral replication early after HIV-1 acquisition, when infectivity is high. We compared cervical HIV-1 RNA from 60 women with paired samples from within 90 days after HIV-1 acquisition and at viral setpoint (4-24 months). Cervical HIV-1 was higher in early compared with setpoint samples (mean 3.43 versus 2.85 log10 copies/swab, P < 0.001). After adjusting for HIV-1-plasma RNA, cervical HIV-1 RNA from 30 days or less after infection was increased by 0.45 log10 copies/swab (P = 0.006).
authors.affiliation: Department of Epidemiology, University of Washington, Seattle, Washington, USA.
authors.forename: Ludo
authors.initials: L
authors.lastname: Lavreys
authors.forename: Jared M
authors.initials: JM
authors.lastname: Baeten
authors.forename: Dana D
authors.initials: DD
authors.lastname: Panteleeff
authors.forename: Barbra A
authors.initials: BA
authors.lastname: Richardson
authors.forename: R Scott
authors.initials: RS
authors.lastname: McClelland
authors.forename: Varsha
authors.initials: V
authors.lastname: Chohan
authors.forename: Kishorchandra
authors.initials: K
authors.lastname: Mandaliya
authors.forename: Jeckoniah O
authors.initials: JO
authors.lastname: Ndinya-Achola
authors.forename: Julie
authors.initials: J
authors.lastname: Overbaugh
mesh_terms: D002584:Cervix Uteri / Q000821:virology*; D005260:Female; D015658:HIV Infections / Q000821:virology*; D015497:HIV-1 / Q000502:physiology*; D006801:Humans; D011446:Prospective Studies; D012367:RNA, Viral / Q000032:analysis* / Q000097:blood; D019562:Viral Load; D014779:Virus Replication / Q000502:physiology
chemical_list: D012367:RNA, Viral