title: Exercise intensity influences cell injury in rat hippocampal slices exposed to oxygen and glucose deprivation.
abstract: We evaluated the effects of two levels of daily forced exercise intensity (moderate and high) in the treadmill over cell susceptibility to oxygen and glucose deprivation (OGD) in hippocampal slices from Wistar rats. Moderate exercise decreased lactate dehydrogenase (LDH) release after OGD, while a significant increase in LDH release was observed in the high intensity group submitted to OGD. Our data corroborate the hypothesis that higher training intensity exacerbates brain damage, while a moderate intensity reduces the injury caused by in vitro ischemia.
authors.affiliation: Programa de Pós Graduação em Ciências Biológicas-Neurociências, RS, Brazil.
authors.forename: Denise
authors.initials: D
authors.lastname: Scopel
authors.forename: Cíntia
authors.initials: C
authors.lastname: Fochesatto
authors.forename: Helena
authors.initials: H
authors.lastname: Cimarosti
authors.forename: Maristela
authors.initials: M
authors.lastname: Rabbo
authors.forename: Adriane
authors.initials: A
authors.lastname: Belló-Klein
authors.forename: Christianne
authors.initials: C
authors.lastname: Salbego
authors.forename: Carlos Alexandre
authors.initials: CA
authors.lastname: Netto
authors.forename: Ionara Rodrigues
authors.initials: IR
authors.lastname: Siqueira
mesh_terms: D000818:Animals; D001681:Biological Assay; D020520:Brain Infarction / Q000503:physiopathology / Q000517:prevention & control* / Q000628:therapy; D002470:Cell Survival / Q000502:physiology; D004734:Energy Metabolism / Q000502:physiology; D005081:Exercise Therapy / Q000009:adverse effects / Q000379:methods* / Q000592:standards; D005947:Glucose / Q000378:metabolism; D020925:Hypoxia-Ischemia, Brain / Q000378:metabolism / Q000503:physiopathology / Q000517:prevention & control*; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008297:Male; D009410:Nerve Degeneration / Q000503:physiopathology / Q000517:prevention & control* / Q000628:therapy; D009924:Organ Culture Techniques; D010101:Oxygen Consumption / Q000502:physiology; D010805:Physical Conditioning, Animal / Q000009:adverse effects / Q000379:methods* / Q000592:standards; D051381:Rats; D015427:Reperfusion Injury / Q000503:physiopathology / Q000517:prevention & control* / Q000628:therapy; D013778:Tetrazolium Salts
chemical_list: D013778:Tetrazolium Salts; D007770:L-Lactate Dehydrogenase; D005947:Glucose