title: [Endoscopic evaluation of mucous membrane inflammation in chronic rhinosinusitis and analysis of correlated factors].
abstract: OBJECTIVE
  The purpose of this article is to establish an endoscopic score system for quantitative evaluation of the inflammation of mucous membrane in patients with chronic rhinosinusitis (CRS) , and to investigate the correlation of this system with a variety of clinical factors.
  
  
  METHODS
  A set of score system was constructed based on anatomic configuration, status of mucous membrane and nasal secretion to evaluate quantificationally the severity of inflammation of CRS. The clinical correlation of this system was studied prospectively in 60 CRS patients, with a variety of clinical factors which included age, duration of disease, previous recurrence and the years from recent recurrence, atopy, serum total immunoglobulin E (TIgE), serum eosinophil cationic protein (ECP), the count of blood eosinophil, the count of tissue inflammatory cell, the extension of CRS indicated by CT, smoking, concomitant chronic inflammation in lower respiratory tract. All above factors were analyzed statistically with the endoscopic score by Pearson correlation and multi-factor linear regression analysis.
  
  
  RESULTS
  In pearson analysis, the correlative factors with the evaluated score included age (x1, r = - 0.310, P = 0.016), the extension of disease (x2, r = 0. 810, P < 0.0005), recurrence (x3, r = 0.408, P = 0.001), eosinophil of nasal tissue (x4, r = 0.279, P = 0. 031), duration of disease (x5, r = 0.536, P < 0.0005), concurrent nasal polyps (r = 0.549, P < 0.0005), plasm cell (r = 0. 317, P = 0.014) and years from the recent recurrence (r = 0.385, P = 0.002). In multi-factor linear regression, the five independent predictive factors were recurrence, age, extension of disease, tissue eosinophils, years of disease. The regressive equation is y = 10.148 - 0.152 (x1) + 2.250 (x2) + 3.348 (x3) + 1.233 (x4) + 0.270 (x5).
  
  
  CONCLUSIONS
  Appropriate score system by nasal endoscopy is feasible to evaluate quantificationally the degree of inflammation of CRS; being appropriately modified, it is even able to reveal the underlying histological behavior finely.
authors.affiliation: Hospital of Otorhinolaryngology, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, China.
authors.forename: Yun-ping
authors.initials: YP
authors.lastname: Fan
authors.forename: Ke-jun
authors.initials: KJ
authors.lastname: Zuo
authors.forename: Geng
authors.initials: G
authors.lastname: Xu
authors.forename: Jian-bo
authors.initials: JB
authors.lastname: Shi
authors.forename: He-xin
authors.initials: HX
authors.lastname: Chen
authors.forename: Jie-bo
authors.initials: JB
authors.lastname: Guo
authors.forename: Li-qiong
authors.initials: LQ
authors.lastname: Liu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002908:Chronic Disease; D004724:Endoscopy; D004804:Eosinophils; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D008297:Male; D008875:Middle Aged; D009298:Nasal Polyps / Q000175:diagnosis / Q000453:epidemiology; D012220:Rhinitis / Q000175:diagnosis* / Q000453:epidemiology*; D012852:Sinusitis / Q000175:diagnosis* / Q000453:epidemiology*; D055815:Young Adult
chemical_list: D007073:Immunoglobulin E