One-pot synthesis of 2,3-dihydro-pyrrolopyridinones using in situ generated formimines.
A novel one-pot methodology is described for the synthesis of functionalized pyrrolopyridinones using in situ generated formimines and an ortho-lithiated pyridinecarboxamide species. Depending on the reaction conditions, this procedure allows versatile access to aminomethylated pyridinecarboxamides, 2,3-dihydro-pyrrolopyridinones, or 1,1-dialkylated 2,3-dihydro-pyrrolopyridinone derivatives. [reaction: see text]
Deguest
Geoffrey
G
Laboratoire de Chimie Organique Fine et Hétérocyclique, IRCOF-INSA Rouen, B.P. 08, 76131 Mont-Saint-Aignan, France.
Devineau
Alice
A
Bischoff
Laurent
L
Fruit
Corinne
C
Marsais
Francis
F