Extrapolation of preclinical data into clinical reality translational science.
Human and animal in vitro models are potentially powerful preclinical tools: prediction of pharmacological behaviour of drugs; selection of animal species most closely related to humans based on metabolic patterns; prediction of drug interactions and explanation of metabolic origins of interindividual variabilities in pharmacological activity. Extrapolation of preclinical data into clinical reality is a translational science and remains an ultimate challenge in drug development.
Singer
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Non-Clinical Safety, Safety and Technical Sciences, Hoffman-La Roche Ltd., Basel, Switzerland. Thomas.singer@roche.com
D000818:Animals; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D004195:Disease Models, Animal; D015195:Drug Design; D004341:Drug Evaluation; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D004345:Drug Industry / Q000379:methods*; D006801:Humans; D008954:Models, Biological; D051381:Rats