Halichondria sulfonic acid, a new HIV-1 inhibitory guanidino-sulfonic acid, and halistanol sulfate isolated from the marine sponge Halichondria rugosa Ridley & Dendy.
A new sulfur-containing guanidino derivative, halichondria sulfonic acid (1) showing anti-HIV-1 activity, and halistanol trisulfate (2) with anti-tumor activity have been isolated from the marine sponge Halichondria rugosa Ridley & Dendy collected in the Chinese Southern Sea. The structure of 1 was elucidated by analysis of spectroscopic and crystal data.
Jin
Y
Y
Marine Bio-products Engineering Group, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.
Fotso
S
S
Yongtang
Z
Z
Sevvana
M
M
Laatsch
H
H
Zhang
W
W
D000818:Animals; D019380:Anti-HIV Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D002681:China; D018360:Crystallography, X-Ray; D004797:Enzyme-Linked Immunosorbent Assay; D006146:Guanidines / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D015497:HIV-1 / Q000187:drug effects*; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D009792:Oceans and Seas; D011161:Porifera / Q000737:chemistry*; D013055:Spectrophotometry, Infrared; D013057:Spectrum Analysis; D013261:Sterols / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D013451:Sulfonic Acids / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D013778:Tetrazolium Salts; D013844:Thiazoles
D019380:Anti-HIV Agents; D006146:Guanidines; C518347:Halichondria sulfonic acid; D013261:Sterols; D013451:Sulfonic Acids; D013778:Tetrazolium Salts; D013844:Thiazoles; C072244:halistanol trisulfate; C022616:thiazolyl blue