title: p16(INK4a) promoter hypermethylation in oral scrapings of oral squamous cell carcinoma risk patients.
abstract: Aberrant promoter hypermethylation is common in oral squamous cell carcinoma (OSCC) and may be useful as a marker for cancer cells. The aim of our study was to assess whether the detection of hypermethylation of the promoter region of p16(INK4a) in oral cytological samples could be a marker in patients with risk of developing an OSCC. Hypermethylation was detected in 20% (29/145) of the cases analyzed. These findings provide further evidence that the inactivation of p16(INK4a), due to methylation, is an early event in the carcinogenic pathway of OSCC.
authors.affiliation: Oral Medicine and Pathology, University of the Basque Country EHU, Vizcaya, Spain.
authors.forename: María Teresa
authors.initials: MT
authors.lastname: Ruesga
authors.forename: Amelia
authors.initials: A
authors.lastname: Acha-Sagredo
authors.forename: María José
authors.initials: MJ
authors.lastname: Rodríguez
authors.forename: José Ignacio
authors.initials: JI
authors.lastname: Aguirregaviria
authors.forename: Juan
authors.initials: J
authors.lastname: Videgain
authors.forename: Carlos
authors.initials: C
authors.lastname: Rodríguez
authors.forename: María de los Angeles Martínez
authors.initials: Mde L
authors.lastname: de Pancorbo
authors.forename: José Manuel
authors.initials: JM
authors.lastname: Aguirre
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000428:Alcohol Drinking; D014408:Biomarkers, Tumor / Q000032:analysis; D002294:Carcinoma, Squamous Cell / Q000235:genetics; D019175:DNA Methylation; D005260:Female; D019942:Genes, p16; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa / Q000166:cytology; D009062:Mouth Neoplasms / Q000235:genetics*; D011230:Precancerous Conditions / Q000235:genetics; D011401:Promoter Regions, Genetic; D012306:Risk; D012907:Smoking
chemical_list: D014408:Biomarkers, Tumor