title: New-onset diabetes after kidney transplantation: risk factors.
abstract: New-onset diabetes after transplantation (NODAT) contributes to the risk for cardiovascular disease and infection, reducing graft and patient survival. For improvement of the outcome of kidney transplant recipients, it is of great interest to know precisely the risk factors that contribute to NODAT development. Nonmodifiable risk factors for development of NODAT are age, race, genetic background, family history of diabetes, and previous glucose intolerance. Modifiable risk factors are obesity and overweight, hepatitis C virus and cytomegalovirus infections, and immunosuppressive drugs. Both steroids and calcineurin inhibitors influence the appearance of NODAT, whereas the role of sirolimus in glucose metabolism currently is controversial.
authors.affiliation: Nephrology service, University of Cantabria, Avda. Valdecilla s/n 39008, Santander, Spain.
authors.forename: Emilio
authors.initials: E
authors.lastname: Rodrigo
authors.forename: Gema
authors.initials: G
authors.lastname: Fernández-Fresnedo
authors.forename: Rosalía
authors.initials: R
authors.lastname: Valero
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: Ruiz
authors.forename: Celestino
authors.initials: C
authors.lastname: Piñera
authors.forename: Rosa
authors.initials: R
authors.lastname: Palomar
authors.forename: Julio
authors.initials: J
authors.lastname: González-Cotorruelo
authors.forename: Carlos
authors.initials: C
authors.lastname: Gómez-Alamillo
authors.forename: Manuel
authors.initials: M
authors.lastname: Arias
mesh_terms: D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology* / Q000209:etiology / Q000235:genetics; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects; D016030:Kidney Transplantation / Q000009:adverse effects*; D009765:Obesity / Q000150:complications; D012307:Risk Factors; D014777:Virus Diseases / Q000150:complications
chemical_list: D007166:Immunosuppressive Agents