Occurrence of cerebral venous sinus thrombosis in patients with presumed idiopathic intracranial hypertension.
OBJECTIVE
To report the rate of occurrence of cerebral venous sinus thrombosis (CVST) in patients with presumed idiopathic intracranial hypertension (IIH).


METHODS
Retrospective chart review.


METHODS
All patients diagnosed with papilledema from November 1, 2002, through October 31, 2003, at 3 tertiary care neuro-ophthalmology centers.


METHODS
Consecutive patients with a diagnosis of papilledema from 3 tertiary care neuro-ophthalmology centers were identified. Patients with space-occupying lesions, hydrocephalus, or meningitis were excluded. The remaining patients were evaluated with lumbar puncture, magnetic resonance imaging (MRI), and magnetic resonance venography (MRV).


METHODS
The rate of occurrence of CVST in patients with presumed IIH.


RESULTS
One hundred thirty-one patients with papilledema were identified. Excluding patients with mass lesions, meningitis, or hydrocephalus, the occurrence of CVST was 10 (9.4%) of 106 patients with presumed IIH. Two additional patients had a diagnosis of suspected CVST. Cerebral venous sinus thrombosis was diagnosed in 1 of the 10 patients with MRI alone, whereas it was evident in all 10 patients with MRV. Underlying risk factors for CVST were identified in 9 of 10 patients.


CONCLUSIONS
Cerebral venous sinus thrombosis accounts for 9.4% of patients with presumed IIH in 3 tertiary care neuro-ophthalmology services. Magnetic resonance venography in combination with MRI is recommended to identify this subgroup of patients.
Lin
Albert
A
Neuro-ophthalmology Service, Cullen Eye Institute, Baylor College of Medicine, Houston, Texas 77030, USA.
Foroozan
Rod
R
Danesh-Meyer
Helen V
HV
De Salvo
Gabriella
G
Savino
Peter J
PJ
Sergott
Robert C
RC
D000293:Adolescent; D000328:Adult; D000368:Aged; D002550:Cerebral Veins; D015170:Cerebrospinal Fluid Pressure; D002648:Child; D005260:Female; D006801:Humans; D020767:Intracranial Thrombosis / Q000209:etiology*; D018810:Magnetic Resonance Angiography; D008297:Male; D010211:Papilledema / Q000150:complications; D010690:Phlebography; D011559:Pseudotumor Cerebri / Q000150:complications*; D012189:Retrospective Studies; D012307:Risk Factors; D012851:Sinus Thrombosis, Intracranial / Q000209:etiology*