title: Ionisation cluster-size formation by electrons: from macroscopic to nanometric target sizes.
abstract: An indispensable prerequisite for a deeper understanding of specified physical, chemical or biological changes initiated in matter when being exposed to ionising radiation is a detailed knowledge of particle track structure. Here, the structure of electron tracks is of particular interest since electrons are set in motion in large numbers as secondary particles during the slow down of any kind of ionising radiation in matter. From the point of view of radiation induced early damage to genes and cells, which starts with the early damage to segments of the DNA molecule, the most effective secondary electrons are those at energies of a few hundred eV since the yield of double-strand breaks induced by such electrons in the DNA shows a maximum. This can be explained by the fact that in water cylinders, 2 nm in diameter and height (as a substitute to small segments of the DNA), the probability of the electron-induced formation of ionisation cluster sizes greater than or equal to two is highest also at initial electron energies of a few hundred eV. In view of this promising feature of ionisation cluster-size distributions formed by low-energy electrons in nanometric targets of liquid water for explaining particular radio-biological endpoints, it is the aim of the present work to investigate the properties of cluster-size formation by electrons as a function of target size. Here, main emphasis is laid on the behaviour of cluster-size distributions if the target size is reduced from macroscopic to nanometric volumes.
authors.affiliation: Department of Fundamentals of Dosimetry, Physikalisch-Technische Bundesanstalt, Bundesallee 100, D-38116 Braunschweig, Germany. Bernd.Grosswendt@ptb.de
authors.forename: B
authors.initials: B
authors.lastname: Grosswendt
mesh_terms: D016000:Cluster Analysis; D003198:Computer Simulation; D004247:DNA / Q000737:chemistry* / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D004583:Electrons; D008956:Models, Chemical; D036103:Nanotechnology / Q000379:methods*; D011829:Radiation Dosage; D011839:Radiation, Ionizing; D011874:Radiometry / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D004247:DNA