Polymeric micelles for drug delivery.
Polymeric micelles are nanoscopic core/shell structures formed by amphiphilic block copolymers. Both the inherent and modifiable properties of polymeric micelles make them particularly well suited for drug delivery purposes. An emphasis of this review has been placed on both the description and characterization techniques of the physical properties of polymeric micelles. Relevant properties discussed include micellar association, morphology, size and stability. These properties and characterization techniques are included to provide context for the known advantages and applications of polymeric micelles for drug delivery. The advantages and applications discussed include solubilization of poorly soluble molecules, sustained release and size advantages, and protection of encapsulated substances from degradation and metabolism. The three most widely studied block copolymer classes are characterized by their hydrophobic blocks, and are poly(propylene oxide), poly(L-amino acid)s and poly(ester)s. These three classes of block copolymers are reviewed with multiple examples of current research in which formulation techniques with polymeric micelles have been applied to some of the most challenging molecules in the pharmaceutical industry. The polymeric micelles used for drug delivery in these examples have shown the abilities to attenuate toxicities, enhance delivery to desired biological sites and improve the therapeutic efficacy of active pharmaceutical ingredients.
Croy
S R
SR
School of Pharmacy, University of Wisconsin, Madison, Wisconsin, USA.
Kwon
G S
GS
D000596:Amino Acids / Q000737:chemistry; D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D004339:Drug Compounding; D004355:Drug Stability; D008823:Micelles; D008968:Molecular Conformation; D010316:Particle Size; D004364:Pharmaceutical Preparations / Q000737:chemistry; D020442:Poloxamer / Q000737:chemistry; D011091:Polyesters / Q000737:chemistry; D011092:Polyethylene Glycols / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*; D011409:Propylene Glycols / Q000737:chemistry; D012995:Solubility; D013499:Surface Properties
D000596:Amino Acids; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D008823:Micelles; D004364:Pharmaceutical Preparations; D011091:Polyesters; D011108:Polymers; D011409:Propylene Glycols; D020442:Poloxamer; C012504:polypropylene glycol; D011092:Polyethylene Glycols