title: Synthesis and biological activity of 5',9-anhydro-3-purine-isonucleosides as potential anti-hepatitis C virus agents.
abstract: In order to study structure-activity relationships among the derivatives and congeners of 5',9-anhydro-3-(beta-D-ribofuranosyl)xanthine for anti-hepatitis C virus activity, a series of 5',9-anhydro-purine-isonucleosides with a substituent (s) at 6- or/and 8-position of the purine moiety were synthesized, and their anti-hepatitis C virus activity and cytotoxicity were evaluated and discussed.
authors.affiliation: Pharmasset, Inc., Princeton, New Jersey 08540, USA. kwon.chun@pharmasset.com
authors.forename: Byoung-Kwon
authors.initials: BK
authors.lastname: Chun
authors.forename: Peiyuan
authors.initials: P
authors.lastname: Wang
authors.forename: Abdalla
authors.initials: A
authors.lastname: Hassan
authors.forename: Jinfa
authors.initials: J
authors.lastname: Du
authors.forename: Phillip M
authors.initials: PM
authors.lastname: Tharnish
authors.forename: Eisuke
authors.initials: E
authors.lastname: Murakami
authors.forename: Lieven
authors.initials: L
authors.lastname: Stuyver
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Otto
authors.forename: Raymond F
authors.initials: RF
authors.lastname: Schinazi
authors.forename: Kyoichi A
authors.initials: KA
authors.lastname: Watanabe
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D002478:Cells, Cultured; D016174:Hepacivirus / Q000187:drug effects*; D006801:Humans; D011684:Purine Nucleosides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D012367:RNA, Viral / Q000187:drug effects; D013329:Structure-Activity Relationship; D014779:Virus Replication / Q000187:drug effects
chemical_list: D000998:Antiviral Agents; D011684:Purine Nucleosides; D012367:RNA, Viral