Synthesis and biological activity of 4'',6''-unsaturated cyclic ADP-carbocyclic-ribose.
4'',6''-Unsaturated cyclic ADP-carbocyclic-ribose (3) was designed as a novel stale mimic of cyclic ADP-ribose, an intracellular Ca2+-mobilizing second messenger, based on the previous SAR studies, and was successfully synthesized.
Kudoh
Takashi
T
Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo 060-0812, Japan.
Murayama
Takashi
T
Matsuda
Akira
A
Shuto
Satoshi
S
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002478:Cells, Cultured; D036563:Cyclic ADP-Ribose / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D051379:Mice
C439996:cyclic ADP-carbocyclic-ribose; D036563:Cyclic ADP-Ribose; D002118:Calcium