Lymphatic recovery of exogenous oleic acid in rats on long chain or specific structured triacylglycerol diets.
Specific structured triacylglycerols, MLM (M = medium-chain fatty acid, L = long-chain fatty acid), rapidly deliver energy and long-chain fatty acids to the body and are used for longer periods in human enteral feeding. In the present study rats were fed diets of 10 wt% MLM or LLL (L = oleic acid [18:1 n-9], M = caprylic acid [8:01) for 2 wk. Then lymph was collected 24 h following administration of a single bolus of 13C-labeled MLM or LLL. The total lymphatic recovery of exogenous 18:1 n-9 24 h after administration of a single bolus of MLM or LLL was similar in rats on the LLL diet (43% and 45%, respectively). However, the recovery of exogenous 18:1 n-9 was higher after a single bolus of MLM compared with a bolus of LLL in rats on the MLM diet (40% and 24%, respectively, P = 0.009). The recovery of lymphatic 18:1 n-9 of the LLL bolus tended to depend on the diet triacylglycerol structure and composition (P= 0.07). This study demonstrated that with a diet containing specific structured triacylglycerol, the lymphatic recovery of 18:1 n-9 after a single bolus of fat was dependent on the triacylglycerol structure of the bolus. This indicates that the lymphatic recovery of long-chain fatty acids from a single meal depends on the overall long-chain fatty acid composition of the habitual diet. This could have implications for enteral feeding for longer periods.
Vistisen
Bodil
B
BioCentrum-DTU, Section of Biochemistry & Nutrition, The Technical University of Denmark, 2800 Lyngby, Denmark. bkgv@kvl.dk
Mu
Huiling
H
Høy
Carl-Erik
CE
D000284:Administration, Oral; D000818:Animals; D004041:Dietary Fats / Q000008:administration & dosage / Q000378:metabolism*; D008196:Lymph / Q000737:chemistry / Q000187:drug effects* / Q000378:metabolism*; D008297:Male; D019301:Oleic Acid / Q000008:administration & dosage / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D013329:Structure-Activity Relationship; D014280:Triglycerides / Q000008:administration & dosage / Q000378:metabolism*
D004041:Dietary Fats; D014280:Triglycerides; D019301:Oleic Acid