title: Receptor communication within the lymphocyte plasma membrane: a role for the thrombospondin family of matricellular proteins.
abstract: Lymphocytes, the principal cells of the immune system, carry out immune surveillance throughout the body by their unique capacity to constantly reposition themselves between a free-floating vascular state and a tissue state characterized by migration and frequent adhesive interactions with endothelial cells and components of the extracellular matrix. Therefore, mechanisms co-ordinating adhesion and migration with signals delivered through antigen recognition probably play a pivotal role for the regulation of lymphocyte behaviour and function. Endogenous thrombospondin-1 (TSP-1) seems to be the hub in such a mechanism for autocrine regulation of T cell adhesion and migration. TSP-1 functions as a mediator of cis interaction of vital receptors within the T lymphocyte plasma membrane, including integrins, low density lipoprotein receptor-related protein, calreticulin and integrin-associated protein.
authors.affiliation: Department of Laboratory Medicine, Division of Clinical Immunology, Karolinska Institute at Karolinska University Hospital Huddinge, SE-141 86, Stockholm, Sweden.
authors.forename: A
authors.initials: A
authors.lastname: Forslöw
authors.forename: Z
authors.initials: Z
authors.lastname: Liu
authors.forename: K-G
authors.initials: KG
authors.lastname: Sundqvist
mesh_terms: D000818:Animals; D019898:Autocrine Communication; D002448:Cell Adhesion; D002462:Cell Membrane / Q000378:metabolism; D002465:Cell Movement; D005109:Extracellular Matrix / Q000737:chemistry; D006801:Humans; D007107:Immune System / Q000502:physiology; D018448:Models, Immunological; D011956:Receptors, Cell Surface / Q000378:metabolism*; D013601:T-Lymphocytes / Q000166:cytology* / Q000276:immunology* / Q000378:metabolism; D019699:Thrombospondins / Q000737:chemistry / Q000378:metabolism*
chemical_list: D011956:Receptors, Cell Surface; D019699:Thrombospondins