title: Recent advances in proton pump inhibitors and management of acid-peptic disorders.
abstract: Acid-peptic ulcers and diseases have been increasingly on rise in today's era of globalization, which is characterized by hurry, worry, and curry. This review summarizes various disorders associated with increased gastric acid secretion and various therapeutic strategies to control them. The emphasis has been laid, in particular, on the role of proton pump inhibitors (PPIs) widely used nowadays for the treatment of gastric acid diseases. The medicinal chemistry aspects and mechanism of action of irreversible PPIs and APAs have been discussed at molecular levels. The ongoing research status in this field has also been covered. Further, biological evaluation methods that can be used for screening of PPIs are also discussed in short.
authors.affiliation: Sinhgad College of Pharmacy, Pune 411 041, India. ks_jain@vsnl.net
authors.forename: Kishor S
authors.initials: KS
authors.lastname: Jain
authors.forename: Anamik K
authors.initials: AK
authors.lastname: Shah
authors.forename: Jitender
authors.initials: J
authors.lastname: Bariwal
authors.forename: Suhas M
authors.initials: SM
authors.lastname: Shelke
authors.forename: Amol P
authors.initials: AP
authors.lastname: Kale
authors.forename: Jayshree R
authors.initials: JR
authors.lastname: Jagtap
authors.forename: Ashok V
authors.initials: AV
authors.lastname: Bhosale
mesh_terms: D000818:Animals; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D005744:Gastric Acid / Q000378:metabolism; D005764:Gastroesophageal Reflux / Q000188:drug therapy*; D016481:Helicobacter Infections / Q000188:drug therapy*; D006801:Humans; D010437:Peptic Ulcer / Q000188:drug therapy*; D054328:Proton Pump Inhibitors
chemical_list: D000897:Anti-Ulcer Agents; D054328:Proton Pump Inhibitors