title: Correlation between the anatomical and functional human subthalamic nucleus.
abstract: This work addresses the spatial correlation between the anatomical and functional human subthalamic nucleus (STN). The anatomical STN (A-STN), derived from the Schaltenbrand-Wahren brain atlas, is histology based. The functional STN (F-STN) is probabilistic, constructed from neuroelectrophysiological and neuroimaging data of 184 Parkinson's disease patients. The A-STN and F-STN are placed in the same space and compared in terms of mutual relative overlapping of anatomy with function. The F-STN and A-STN correlate well for medium and high probabilities of the F-STN. For probability p >or= 0.3, >95% of F-STN is inside the A-STN, and for p >or= 0.5, the complete F-STN is inside the A-STN for each left and right STN. Therefore, the F-STN for p = 0.5 can potentially be used for identification of the STN in neuroimages.
authors.affiliation: Biomedical Imaging Lab, Agency for Science, Technology and Research, Singapore, Singapore. wieslaw@sbic.a-star.edu.sg
authors.forename: Wieslaw L
authors.initials: WL
authors.lastname: Nowinski
authors.forename: A
authors.initials: A
authors.lastname: Thirunavuukarasuu
authors.forename: Jimin
authors.initials: J
authors.lastname: Liu
authors.forename: Alim Louis
authors.initials: AL
authors.lastname: Benabid
mesh_terms: D000716:Anatomy, Artistic; D003952:Diagnostic Imaging; D004594:Electrophysiology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008433:Mathematics; D008488:Medical Illustration; D010300:Parkinson Disease / Q000473:pathology* / Q000503:physiopathology; D013238:Stereotaxic Techniques; D020531:Subthalamic Nucleus / Q000033:anatomy & histology* / Q000502:physiology*; D014057:Tomography, X-Ray Computed