title: Chemical modifications rescue off-target effects of RNAi.
abstract: RNAi's specificity has been questioned for some time. Three recent papers show that off-target effects should be considered normal, but one paper also provides insight on how chemical modifications of siRNAs may overcome the problem.
authors.affiliation: Division of Molecular Biology, Graduate School of Biological Sciences, Beckman Research Institute of the City of Hope, 1450 East Duarte Road, Duarte, California 91010, USA.
authors.forename: Ola
authors.initials: O
authors.lastname: Snøve
authors.forename: John J
authors.initials: JJ
authors.lastname: Rossi
mesh_terms: D000818:Animals; D018390:Gene Targeting / Q000379:methods*; D006801:Humans; D034622:RNA Interference / Q000502:physiology*; D034741:RNA, Small Interfering / Q000737:chemistry* / Q000235:genetics*
chemical_list: D034741:RNA, Small Interfering