Regulation and recognization of the extended G-quadruplex by rutin.
Rutins, a kind of flavonoid glycoside, showed different absorption and fluorescence spectral characteristics when bound to blunt-end stacked and interlocked extended G-quadruplexes. Further (1)H NMR spectra showed these two extended G-quadruplexes bound with rutins in different manners: after binding, the blunt-end stacked extended G-quadruplexes were decomposed to monomers, and the interlocked extended G-quadruplexes did not change. Based on these spectral features, one may expect the usage of rutins in recognizing different structural extended G-quadruplexes and regulating the ratio between blunt-end stacked extended G-quadruplexes and monomers.
Sun
Hongxia
H
Beijing National Laboratory for Molecular Sciences (BNLMS), State Key Laboratory for Structural Chemistry of Unstable and Stable Species, Center for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, PR China.
Xiang
Junfeng
J
Tang
Yalin
Y
Xu
Guangzhi
G
D004247:DNA / Q000737:chemistry*; D054856:G-Quadruplexes; D006150:Guanine Nucleotides / Q000737:chemistry*; D015394:Molecular Structure; D012431:Rutin / Q000737:chemistry*; D013057:Spectrum Analysis
D006150:Guanine Nucleotides; D012431:Rutin; D004247:DNA