Effects of various cations on the dynamic and thermodynamics of the dimerization of G-quadruplex DNA.
DNA fragment, d(TTAGGG), forms all-parallel G-quadruplex in the presence of K(+).(1) We found that G-quadruplex d(TTAGGG) dimerizes through end-to-end stacking of the 3'-terminal G-quartets.(2) In this study, we report the effects of Mg(2+) and Ca(2+) on the dynamics and thermodynamics of the dimerization.
Mita
Hajime
H
Department of Chemistry, University of Tsukuba, Tsukuba 305-8571, Japan.
Kato
Yoshitake
Y
Ozawa
Makie
M
Fujisaki
Toshinori
T
Yamamoto
Yasuhiko
Y
D002118:Calcium / Q000737:chemistry*; D002413:Cations, Divalent / Q000737:chemistry; D004247:DNA / Q000737:chemistry*; D019281:Dimerization; D054856:G-Quadruplexes; D006801:Humans; D008274:Magnesium / Q000737:chemistry*; D019906:Nuclear Magnetic Resonance, Biomolecular; D016615:Telomere / Q000737:chemistry; D013816:Thermodynamics
D002413:Cations, Divalent; D004247:DNA; D008274:Magnesium; D002118:Calcium