title: From embryos to embryonic stem cells: biopolitics and therapeutic potential.
abstract: The inner cell mass of the preimplantation blastocyst, from which all the cells of the body develop, is a source of embryonic stem cells. These cells can be maintained in their undifferentiated state over long periods in culture and yet retain their pluripotency. The generation of human stem cells capable of differentiating into all the cell types of the human body opens the way for the use of these cells in therapeutic transplantation for a myriad of diseases. However, as discussed here, there are a number of logistical, biological, and clinical hurdles that must be overcome prior to the use of these cells in routine clinical practice.
authors.affiliation: Stem Cell Biology Laboratory, Wolfson Centre for Age Related Disease, King's College, London SE1 1UL, UK. cedars@lsbu.ac.uk
authors.forename: S H
authors.initials: SH
authors.lastname: Cedar
authors.forename: J A
authors.initials: JA
authors.lastname: Cooke
authors.forename: Z
authors.initials: Z
authors.lastname: Luo
authors.forename: M J
authors.initials: MJ
authors.lastname: Patel
authors.forename: S L
authors.initials: SL
authors.lastname: Minger
mesh_terms: D002454:Cell Differentiation / Q000502:physiology*; D033041:Embryo Research / Q000941:ethics; D053595:Embryonic Stem Cells / Q000637:transplantation*; D006801:Humans; D009924:Organ Culture Techniques / Q000379:methods; D011057:Politics; D033581:Stem Cell Transplantation / Q000941:ethics / Q000379:methods*