title: Synthesis and biological activity of phosphonated nucleosides: part 1. Furanose, carbocyclic and heterocyclic analogues.
abstract: Phosphonated nucleosides represent a promising alternative in the improvement of the biological activity of nucleoside analogues in antiviral and anticancer chemotherapy. The basic concept, the chemistry, the different structural modifications and their effects on the antiviral potency will be discussed in this review.
authors.affiliation: Dipartimento Farmaco-Chimico, Universita' degli Studi di Messina, Viale S.S. Annunziata, 98168 Messina, Italy. apiperno@pharma.unime.it
authors.forename: Anna
authors.initials: A
authors.lastname: Piperno
authors.forename: Maria A
authors.initials: MA
authors.lastname: Chiacchio
authors.forename: Daniela
authors.initials: D
authors.lastname: Iannazzo
authors.forename: Roberto
authors.initials: R
authors.lastname: Romeo
mesh_terms: D005663:Furans / Q000737:chemistry* / Q000494:pharmacology*; D009705:Nucleosides / Q000138:chemical synthesis* / Q000494:pharmacology*; D017553:Phosphorus Compounds / Q000737:chemistry
chemical_list: D005663:Furans; D009705:Nucleosides; D017553:Phosphorus Compounds