Constitutive activation of NF-kappa B is not sufficient to disturb normal steady-state hematopoiesis.
Since nuclear factor-kappaB (NF-kappaB) is frequently activated in acute myeloid leukemia, we questioned whether active NF-kappaB can affect the cellular properties of cord blood CD34+ cells. The results demonstrated that NF-kappaB activation did not influence growth or differentiation properties of these cells. Furthermore, NF-kappaB activation was not sufficient to induce changes in stem- and progenitor cell numbers.
Schepers
Hein
H
Eggen
Bart J L
BJ
Schuringa
Jan Jacob
JJ
Vellenga
Edo
E
D002460:Cell Line; D006410:Hematopoiesis / Q000502:physiology*; D006801:Humans; D016328:NF-kappa B / Q000378:metabolism*
D016328:NF-kappa B