[Complex influence of pharmacological agents on degenerative processes in brain of Drosophila melanogaster mutants].
A scheme of complex administration of drugs in the order neuroprotector + neuroactivator + neuroretarder for the treatment of neurodegenerative processes in the brain has been elaborated and tested on a model object representing neurodegenerative mutants of Drosophila melanogaster. The appearance of changes in the brain was delayed when drugs were used separately: donepezil hydrochloride (arisept), 10 - 11 days, epinephrine and nimodipine, 1 - 2 days. The treatment of flies with the same drugs in the order arisept + epinephrine + nimodipine leads to the complete regeneration of D. melanogaster brain tissue to within 15 days of imago life.
Radysh
V V
VV
Maksymiv
D V
DV
Makarenko
A N
AN
D000818:Animals; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D004195:Disease Models, Animal; D000077265:Donepezil; D004331:Drosophila melanogaster; D004359:Drug Therapy, Combination; D004837:Epinephrine / Q000627:therapeutic use*; D007189:Indans / Q000627:therapeutic use*; D009154:Mutation; D019636:Neurodegenerative Diseases / Q000188:drug therapy* / Q000235:genetics; D009553:Nimodipine / Q000627:therapeutic use*; D018697:Nootropic Agents / Q000627:therapeutic use*; D010880:Piperidines / Q000627:therapeutic use*
D002121:Calcium Channel Blockers; D007189:Indans; D018697:Nootropic Agents; D010880:Piperidines; D009553:Nimodipine; D000077265:Donepezil; D004837:Epinephrine