[Effects of oxysophoridine on Glu and GABA immuno-reaction positive neurons in cortex and hippocampus of rats].
OBJECTIVE
To study the effect of oxysophoridine (OSR) on glutamate (Glu) and gamma aminobutyric acid (GABA) immuno-reaction positive neurons in the cortex and hippocampus of rats.


METHODS
Immunohistochemistry method (SABC) and the micrographic analysis technique were employed to monitor the effect of OSR in the variations of Glu and GABA immunoreaction positive neurons in the cortex and hippocampus of rats.


RESULTS
OSR administrated icv (10 mg) significantly increased the number of GABA immuno-reaction positive neurons while decreasing the number of glu immunoreaction positive neurons in cortex and hippocampus in rats (P < 0.05).


CONCLUSIONS
Results showed that the change of Glu and GABA caused by OSR may responsible for its inhibitory effects on the central nervous system.
Yu
Jian-Qiang
JQ
Department of Pharmacology, Ningxia Medical College, Yinchuan 750004, China. jian-gyuanxu33@hotmail.com
Jiang
Yuan-Xu
YX
D000470:Alkaloids / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D002540:Cerebral Cortex / Q000378:metabolism* / Q000648:ultrastructure; D018698:Glutamic Acid / Q000378:metabolism*; D006624:Hippocampus / Q000378:metabolism* / Q000648:ultrastructure; D007150:Immunohistochemistry / Q000379:methods; D008297:Male; D009474:Neurons / Q000378:metabolism / Q000648:ultrastructure; D010946:Plants, Medicinal / Q000737:chemistry; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D029909:Sophora / Q000737:chemistry; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D000470:Alkaloids; C406983:oxysophoridine; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid