title: Integration and segregation of activity in entorhinal-hippocampal subregions by neocortical slow oscillations.
abstract: Brain systems communicate by means of neuronal oscillations at multiple temporal and spatial scales. In anesthetized rats, we find that neocortical "slow" oscillation engages neurons in prefrontal, somatosensory, entorhinal, and subicular cortices into synchronous transitions between UP and DOWN states, with a corresponding bimodal distribution of their membrane potential. The membrane potential of hippocampal granule cells and CA3 and CA1 pyramidal cells lacked bimodality, yet it was influenced by the slow oscillation in a region-specific manner. Furthermore, in both anesthetized and naturally sleeping rats, the cortical UP states resulted in increased activity of dentate and most CA1 neurons, as well as the highest probability of ripple events. Yet, the CA3-CA1 network could self-organize into gamma bursts and occasional ripples during the DOWN state. Thus, neo/paleocortical and hippocampal networks periodically reset, self-organize, and temporally coordinate their cell assemblies via the slow oscillation.
authors.affiliation: Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, 197 University Avenue, Newark, New Jersey 07102, USA.
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Isomura
authors.forename: Anton
authors.initials: A
authors.lastname: Sirota
authors.forename: Simal
authors.initials: S
authors.lastname: Ozen
authors.forename: Sean
authors.initials: S
authors.lastname: Montgomery
authors.forename: Kenji
authors.initials: K
authors.lastname: Mizuseki
authors.forename: Darrell A
authors.initials: DA
authors.lastname: Henze
authors.forename: György
authors.initials: G
authors.lastname: Buzsáki
mesh_terms: D000758:Anesthesia; D000818:Animals; D003627:Data Interpretation, Statistical; D004594:Electrophysiology; D018728:Entorhinal Cortex / Q000166:cytology / Q000502:physiology*; D005109:Extracellular Matrix / Q000502:physiology; D006624:Hippocampus / Q000166:cytology / Q000502:physiology*; D008297:Male; D008564:Membrane Potentials / Q000502:physiology; D019579:Neocortex / Q000166:cytology / Q000502:physiology*; D009415:Nerve Net / Q000502:physiology; D009474:Neurons / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012890:Sleep / Q000502:physiology