Portopulmonary hypertension.
Portopulmonary hypertension is a common condition in patients who have portal hypertension. This article reviews the definition and clinical presentation of this disorder and outlines our current understanding of its pathophysiology. A diagnostic approach is provided , and novel medical therapies that are being investigated to treat this condition are discussed. Finally, the safety of liver transplantation in patients who have portopulmonary hypertension is reviewed.
Passarella
Michael
M
Department of Medicine, University of Alabama at Birmingham, BDB 327, 1530 3rd Avenue S., Birmingham, AL 35294, USA.
Fallon
Michael B
MB
Kawut
Steven M
SM
D000959:Antihypertensive Agents / Q000627:therapeutic use; D015150:Echocardiography, Doppler; D011464:Epoprostenol / Q000031:analogs & derivatives / Q000627:therapeutic use; D006801:Humans; D006975:Hypertension, Portal / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy; D006976:Hypertension, Pulmonary / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy; D010726:Phosphodiesterase Inhibitors / Q000627:therapeutic use*; D013902:Radiography, Thoracic; D012129:Respiratory Function Tests
D000959:Antihypertensive Agents; D010726:Phosphodiesterase Inhibitors; D011464:Epoprostenol