Synthesis and properties of 2',4'-BNA(NC), a second generation BNA.
We have recently designed and synthesized a novel bridged nucleic acid analogue 2',4'-BNA(NC), bearing an N-O bridged structure, which furnished both higher duplex and triplex-forming abilities and sequence selectivity towards complementary RNA and/or DNA, respectively, and showed excellent resistance against nuclease degradation. Duplex and triplex-forming abilities were slightly higher or similar to those of 2',4'-BNA and nuclease resistance was as high as that of S-oligo.
Rahman
S M Abdur
SM
Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan.
Seki
Sayori
S
Utsuki
Kazushige
K
Obika
Satoshi
S
Miyashita
Kazuyuki
K
Imanishi
Takeshi
T
D001952:Bridged-Ring Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D004247:DNA / Q000737:chemistry; D009693:Nucleic Acid Hybridization; D009841:Oligonucleotides / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D043264:Phosphodiesterase I; D012313:RNA / Q000737:chemistry; D013938:Thymidine Monophosphate / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism
D001952:Bridged-Ring Compounds; D009841:Oligonucleotides; D013938:Thymidine Monophosphate; D012313:RNA; D004247:DNA; D043264:Phosphodiesterase I; C470790:phosphodiesterase I, snake venom