Development of DNA-intercalator-polyamine multi-conjugate bearing the ability of the sequence-specific RNA hydrolysis.
A Novel anthraquinone-trisamine modified DNA conjugate was developed. The trisamine-bearing 2,7-disubstituted anthraquinone derivative was introduced into the central position of the DNA oligomer. The ability of the sequence-specific RNA cleavage of this novel modified DNA was investigated.
Moriguchi
Tomohisa
T
Department of Chemistry, Gunma University, 1-5-1 Tenjincho, Kiryu, Gunma 376-8515, Japan.
Ohike
Tomoyuki
T
Shinozuka
Kazuo
K
D000880:Anthraquinones / Q000737:chemistry*; D001483:Base Sequence; D021881:DNA, Catalytic / Q000138:chemical synthesis / Q000737:chemistry*; D004722:Endoribonucleases / Q000737:chemistry*; D005021:Ethylamines / Q000737:chemistry*; D006868:Hydrolysis; D007364:Intercalating Agents / Q000737:chemistry*; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis / Q000737:chemistry; D012313:RNA / Q000737:chemistry / Q000378:metabolism; D013379:Substrate Specificity
D000880:Anthraquinones; D021881:DNA, Catalytic; D005021:Ethylamines; D007364:Intercalating Agents; D009838:Oligodeoxyribonucleotides; D012313:RNA; D004722:Endoribonucleases