Structural effect of cationic copolymers on nucleic acid-chaperoning activity.
In order to evaluate the effect of cationic copolymer structures on their nucleic acid-chaperoning activity, we prepared various copolymers having different cationic residues or backbone molecular weight. It was revealed that nucleic acid-chaperoning activity increases with increasing molecular weight of the copolymer backbone and that the copolymer having the guanidino groups is effective for increasing nucleic acid-chaperoning activity. Compared with PLL-g-Dex, GPLL-g-Dex has weak activity to stabilize ds DNA. This weak stabilization effect of GPLL-g-Dex may contribute to the higher accelerating effect.
Takada
Kaoru
K
Institute for Materials Chemistry and Engineering, Kyushu University, 6-10-1 Hakozaki, Fukuoka 812-8581, Japan.
Choi
Sung Won
SW
Yamayoshi
Asako
A
Kano
Arihiro
A
Maruyama
Atsushi
A
D004247:DNA / Q000737:chemistry*; D003911:Dextrans / Q000737:chemistry*; D018832:Molecular Chaperones / Q000737:chemistry*; D011107:Polylysine / Q000031:analogs & derivatives* / Q000737:chemistry; D013329:Structure-Activity Relationship
D003911:Dextrans; D018832:Molecular Chaperones; C113090:poly(lysine)-graft-dextran; C520216:polylysine-graft-poly(N(epsilon)-amidinolysine)-graft-dextran; D011107:Polylysine; D004247:DNA