title: Synthesis and properties of 2',4'-BNA(NC), a second generation BNA.
abstract: We have recently designed and synthesized a novel bridged nucleic acid analogue 2',4'-BNA(NC), bearing an N-O bridged structure, which furnished both higher duplex and triplex-forming abilities and sequence selectivity towards complementary RNA and/or DNA, respectively, and showed excellent resistance against nuclease degradation. Duplex and triplex-forming abilities were slightly higher or similar to those of 2',4'-BNA and nuclease resistance was as high as that of S-oligo.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan.
authors.forename: S M Abdur
authors.initials: SM
authors.lastname: Rahman
authors.forename: Sayori
authors.initials: S
authors.lastname: Seki
authors.forename: Kazushige
authors.initials: K
authors.lastname: Utsuki
authors.forename: Satoshi
authors.initials: S
authors.lastname: Obika
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Miyashita
authors.forename: Takeshi
authors.initials: T
authors.lastname: Imanishi
mesh_terms: D001952:Bridged-Ring Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D004247:DNA / Q000737:chemistry; D009693:Nucleic Acid Hybridization; D009841:Oligonucleotides / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D043264:Phosphodiesterase I; D012313:RNA / Q000737:chemistry; D013938:Thymidine Monophosphate / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism
chemical_list: D001952:Bridged-Ring Compounds; D009841:Oligonucleotides; D013938:Thymidine Monophosphate; D012313:RNA; D004247:DNA; D043264:Phosphodiesterase I; C470790:phosphodiesterase I, snake venom