title: Three-dimensional structure of the ternary complex of yeast tyrosyl-tRNA synthetase.
abstract: The archaeal/eukaryotic tyrosyl tRNA synthetase (TyrRS)-tRNA(Tyr) pairs do not cross-react with their prokaryotic counterparts. Recently, crystal structure analyses of prokaryotic and archaeal TyrRSs complexed with their cognate tRNA(Tyr) have been reported, however, no structure is available for eukaryotic TyrRS complexed with its cognate tRNA(Tyr). Here we report the crystal structure of yeast Tyrosyl-tRNA synthetase (yTyrRS) complexed with its cognate tRNA(Tyr) and Tyr-AMP analog.
authors.affiliation: School of Pharmaceutical Sciences, Showa University, Tokyo 142-8555, Japan.
authors.forename: Masaru
authors.initials: M
authors.lastname: Tsunoda
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Kusakabe
authors.forename: Nobutada
authors.initials: N
authors.lastname: Tanaka
authors.forename: Satoshi
authors.initials: S
authors.lastname: Ohno
authors.forename: Masashi
authors.initials: M
authors.lastname: Nakamura
authors.forename: Toshiya
authors.initials: T
authors.lastname: Senda
authors.forename: Mitsuo
authors.initials: M
authors.lastname: Sekine
authors.forename: Takashi
authors.initials: T
authors.lastname: Yokogawa
authors.forename: Kazuya
authors.initials: K
authors.lastname: Nishikawa
authors.forename: Kazuo T
authors.initials: KT
authors.lastname: Nakamura
mesh_terms: D003460:Crystallization; D018360:Crystallography, X-Ray; D012441:Saccharomyces cerevisiae / Q000201:enzymology*; D014448:Tyrosine-tRNA Ligase / Q000737:chemistry*
chemical_list: D014448:Tyrosine-tRNA Ligase