title: Hormone effects on fMRI and cognitive measures of encoding: importance of hormone preparation.
abstract: We compared fMRI and cognitive data from nine hormone therapy (HT)-naive women with data from women exposed to either opposed conjugated equine estrogens (CEE) (n = 10) or opposed estradiol (n = 4). Exposure to either form of HT was associated with healthier fMRI response; however, CEE-exposed women exhibited poorer memory performance than either HT-naive or estradiol-exposed subjects. These preliminary findings emphasize the need to characterize differential neural effects of various HTs.
authors.affiliation: Section of Geriatrics and Gerontology, Department of Medicine, University of Wisconsin, 2870 University Ave., Suite 106, Madison, WI 53705, USA. ceg@medicine.wisc.edu
authors.forename: C E
authors.initials: CE
authors.lastname: Gleason
authors.forename: T W
authors.initials: TW
authors.lastname: Schmitz
authors.forename: T
authors.initials: T
authors.lastname: Hess
authors.forename: R L
authors.initials: RL
authors.lastname: Koscik
authors.forename: M A
authors.initials: MA
authors.lastname: Trivedi
authors.forename: M L
authors.initials: ML
authors.lastname: Ries
authors.forename: C M
authors.initials: CM
authors.lastname: Carlsson
authors.forename: M A
authors.initials: MA
authors.lastname: Sager
authors.forename: S
authors.initials: S
authors.lastname: Asthana
authors.forename: S C
authors.initials: SC
authors.lastname: Johnson
mesh_terms: D003071:Cognition / Q000187:drug effects* / Q000502:physiology; D004958:Estradiol / Q000494:pharmacology*; D015914:Estrogen Replacement Therapy / Q000379:methods; D004966:Estrogens, Conjugated (USP) / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008875:Middle Aged; D017698:Postmenopause / Q000187:drug effects / Q000502:physiology
chemical_list: D004966:Estrogens, Conjugated (USP); D004958:Estradiol