title: Sugihiratake mushroom (angel's wing mushroom)-induced cryptogenic encephalopathy may involve vitamin D analogues.
abstract: In autumn 2004, many Japanese patients with renal failure developed cryptogenic encephalopathy by consuming sugihiratake mushroom, a Japanese delicacy. To elucidate the relationship between the cryptogenic cases and this mushroom, we conducted a multivariate analysis of metabolites in 'Probably Toxic' sugihiratake collected from the area of encephalopathy outbreaks, and 'Probably Safe' sugihiratake collected from unaffected areas using UPLC/ToF MS. The results indicate that the presence of milligram quantities of vitamin D-like compounds per 10 g of dried sugihiratake from the areas of encephalopathy outbreaks. Two hypotheses to induce the encephalopathy are proposed: the found metabolites are (1) vitamin D agonists, which induce acute and severe hypercalcemia and/or hyperammonemia and/or vitamin D toxicity, or (2) vitamin D antagonists, which induce acute and severe hypocalcemia.
authors.affiliation: Nihon Waters K.K., Tokyo, Japan. hideki_sasaki@waters.com
authors.forename: Hideki
authors.initials: H
authors.lastname: Sasaki
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Akiyama
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Yoshida
authors.forename: Kazunari
authors.initials: K
authors.lastname: Kondo
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Amakura
authors.forename: Yoshimasa
authors.initials: Y
authors.lastname: Kasahara
authors.forename: Tamio
authors.initials: T
authors.lastname: Maitani
mesh_terms: D000363:Agaricales; D001927:Brain Diseases / Q000209:etiology*; D005517:Foodborne Diseases; D006801:Humans; D013058:Mass Spectrometry; D014807:Vitamin D / Q000031:analogs & derivatives*
chemical_list: D014807:Vitamin D