title: Properties and application of oligodeoxynucleotides containing the naphthyridine:imidazopyridopyrimidine base pairs with the ability to form four hydrogen bonds.
abstract: As our continuing study to develop base pairing motifs which stabilize and regulate DNA structure, we designed novel 1,8-naphthyridine C-nucleosides possessing Na-O(N) and Na-N(O) bases. These C-nucleosides formed two sets of naphthyridine:imidazopyridopyrimidine base pairing motifs (Na-O(N):Im-N(O) and Na-N(O):Im-O(N)) with four hydrogen bonds, and duplexes containing the pairs were markedly thermally stabilized independent of the manner in which the new pairs are incorporated.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo 060-0812, Japan.
authors.forename: Sadao
authors.initials: S
authors.lastname: Hikishima
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Kuramoto
authors.forename: Noriaki
authors.initials: N
authors.lastname: Minakawa
authors.forename: Akira
authors.initials: A
authors.lastname: Matsuda
mesh_terms: D020029:Base Pairing; D001483:Base Sequence; D006860:Hydrogen Bonding; D007093:Imidazoles / Q000737:chemistry*; D008969:Molecular Sequence Data; D009287:Naphthyridines / Q000737:chemistry*; D009838:Oligodeoxyribonucleotides / Q000737:chemistry* / Q000235:genetics; D011728:Pyridones / Q000737:chemistry*; D011743:Pyrimidines / Q000737:chemistry*
chemical_list: D007093:Imidazoles; D009287:Naphthyridines; D009838:Oligodeoxyribonucleotides; D011728:Pyridones; D011743:Pyrimidines