title: Influence of overweight on surgical complications for gastric cancer: results from a randomized control trial comparing D2 and extended para-aortic D3 lymphadenectomy (JCOG9501).
abstract: BACKGROUND
  The impact of overweight on the outcome of gastrectomy with lymphadenectomy is controversial, and data from a well-controlled, randomized study are needed to identify a possible relationship.
  
  
  METHODS
  We used data from 523 patients registered for a prospective randomized trial comparing D2 and extended para-aortic D3 lymphadenectomy to compare the effects of body mass index (BMI) and the extent of lymphadenectomy for the development of general or major surgical complications (anastomotic leakage, abdominal abscess, and pancreatic fistula).
  
  
  RESULTS
  Seventy-seven patients were classified as overweight with BMI >or= 25, and 38 and 39 of these patients underwent a D2 or D3 lymphadenectomy, respectively. Among the 446 patients classified as nonoverweight with BMI < 25, 225 received D2 and 221 received D3 lymphadenectomy. Surgical complications, operation time, and blood loss were statistically significantly associated with BMI, and logistic regression analysis revealed that overweight directly affected the occurrence of surgical complications even after considering operation time and blood loss as intermediate factors instead of outcome variables. Among patients undergoing D2 lymphadenectomy, being overweight increased the risk for surgical complications and blood loss, whereas overweight was associated with only blood loss and operation time among patients receiving D3 lymphadenectomy.
  
  
  CONCLUSIONS
  Overweight increased the risk of surgical complications in patients undergoing gastrectomy both directly and indirectly through operation time and blood loss. The impact of overweight on surgical complications was more evident in patients undergoing a D2 dissection.
authors.affiliation: Department of Surgery, Osaka National Hospital, 2-1-14 Hoenzaka, Chuo-ku, Osaka, 540-0006, Japan. toshi@onh.go.jp
authors.forename: Toshimasa
authors.initials: T
authors.lastname: Tsujinaka
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Sasako
authors.forename: Seiichiro
authors.initials: S
authors.lastname: Yamamoto
authors.forename: Takeshi
authors.initials: T
authors.lastname: Sano
authors.forename: Yukinori
authors.initials: Y
authors.lastname: Kurokawa
authors.forename: Atsushi
authors.initials: A
authors.lastname: Nashimoto
authors.forename: Akira
authors.initials: A
authors.lastname: Kurita
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Katai
authors.forename: Toshio
authors.initials: T
authors.lastname: Shimizu
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Furukawa
authors.forename: Satoru
authors.initials: S
authors.lastname: Inoue
authors.forename: Masahiro
authors.initials: M
authors.lastname: Hiratsuka
authors.forename: Taira
authors.initials: T
authors.lastname: Kinoshita
authors.forename: Kuniyoshi
authors.initials: K
authors.lastname: Arai
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Yamamura
mesh_terms: D000368:Aged; D015992:Body Mass Index; D005260:Female; D005743:Gastrectomy / Q000009:adverse effects*; D006801:Humans; D008197:Lymph Node Excision / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D050177:Overweight; D013274:Stomach Neoplasms / Q000473:pathology / Q000601:surgery*