title: Fat uses a TOLL-road to connect inflammation and diabetes.
abstract: The link between inflammation and diabetes is well established, but the nature of the link is unresolved. Obesity, inflammation, and insulin resistance are major characteristics of diabetes. A study by Flier and colleagues () identifies Toll-like receptor 4 signaling activated by fatty acids as part of that link. This receptor mediates inflammatory events and insulin resistance in peripheral organs.
authors.affiliation: Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, 500 University Drive (H166), C4600D, Hershey, Pennsylvania 17033, USA.
authors.forename: Jason K
authors.initials: JK
authors.lastname: Kim
mesh_terms: D000818:Animals; D003920:Diabetes Mellitus / Q000276:immunology*; D005227:Fatty Acids / Q000276:immunology*; D006801:Humans; D007249:Inflammation / Q000276:immunology; D007333:Insulin Resistance / Q000276:immunology*; D009765:Obesity / Q000276:immunology*; D051197:Toll-Like Receptor 4 / Q000276:immunology*
chemical_list: D005227:Fatty Acids; C495345:TLR4 protein, human; D051197:Toll-Like Receptor 4