Micromanagement: a role for microRNAs in mRNA stability.
Small, inhibitory RNA molecules called microRNAs cause large decreases in target protein levels through a post-transcriptional mechanism. Until recently, it was believed this mechanism operated almost exclusively at a step in translation. However, new work has revealed that microRNAs have a second, post-transcriptional mechanism that accelerates the rate of deadenylation, the initial step of mRNA decay.
Roush
Sarah F
SF
Department of Molecular Biophysics and Biochemistry, Yale University, P.O. Box 208103, New Haven, Connecticut 06520-8103, USA.
Slack
Frank J
FJ
D000818:Animals; D002460:Cell Line; D016678:Genome; D051379:Mice; D035683:MicroRNAs / Q000235:genetics*; D008957:Models, Genetic; D020411:Oligonucleotide Array Sequence Analysis; D012323:RNA Processing, Post-Transcriptional; D012333:RNA, Messenger / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D014158:Transcription, Genetic
D035683:MicroRNAs; D012333:RNA, Messenger