Antiviral properties of combination peptides of HIV-1 Rev NLS and NES.
Nuclear translocation signal has been identified as a mediator of protein shuttling between nuclear and cytoplasm. Here we report that the combination of peptides from nuclear localization signal (NLS) and nuclear export signal (NES) of HIV-1 Rev have an antiviral activity against the Herpes virus of turkey and Marek's disease virus serotype 1.
Kobayashi
Nahoko
N
Nagoya R&D Institute, Toagosei Co., Ltd., Nagoya 455-0027, Japan.
Sato
Takanori
T
Yoshida
Tetsuhiko
T
D000595:Amino Acid Sequence; D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D002642:Chick Embryo; D015694:Gene Products, rev / Q000737:chemistry / Q000502:physiology*; D015497:HIV-1 / Q000737:chemistry* / Q000502:physiology; D026002:Herpesvirus 1, Meleagrid / Q000254:growth & development / Q000378:metabolism; D008381:Herpesvirus 2, Gallid / Q000254:growth & development / Q000378:metabolism; D006801:Humans; D008969:Molecular Sequence Data; D049790:Nuclear Export Signals / Q000502:physiology*; D019913:Nuclear Localization Signals / Q000502:physiology*; D054321:rev Gene Products, Human Immunodeficiency Virus
D000998:Antiviral Agents; D015694:Gene Products, rev; D049790:Nuclear Export Signals; D019913:Nuclear Localization Signals; D054321:rev Gene Products, Human Immunodeficiency Virus