Feeding with both β-carotene and supplemental α-tocopherol enhances type 1 helper T cell activity among splenocytes isolated from DO11.10 mice.
beta-Carotene and/or supplemental alpha-tocopherol were fed to DO11.10 mice to investigate their effect on the immune function of naive splenocytes. A high secretion of interleukin-12 and interferon-gamma in response to the ex vivo primary antigen presentation occurred only when both were fed. This is consistent with the suppressed immunoglobulin E production under the similar condition described in our previous report.
Koizumi
Tomoko
T
Department of Food Science, Graduate School of Nutrition and Biosciences, The University of Tokushima.
Bando
Noriko
N
Terao
Junji
J
Yamanishi
Rintaro
R
D000818:Animals; D007371:Interferon-gamma / Q000378:metabolism; D018664:Interleukin-12 / Q000378:metabolism; D051379:Mice; D008822:Mice, Transgenic; D013154:Spleen / Q000166:cytology / Q000187:drug effects* / Q000276:immunology; D018417:Th1 Cells / Q000187:drug effects* / Q000276:immunology; D024502:alpha-Tocopherol / Q000008:administration & dosage* / Q000494:pharmacology; D019207:beta Carotene / Q000008:administration & dosage* / Q000494:pharmacology
D019207:beta Carotene; D018664:Interleukin-12; D007371:Interferon-gamma; D024502:alpha-Tocopherol