[Genomic instability in the offspring of irradiated parents: facts and interpretations].
This review is devoted to genomic instability in the offspring of parents that were irradiated or treated with chemical mutagens. The evidence is presented, showing high frequency of cancer diseases and instability of the genome of somatic and germline cells in the offspring of radiation-exposed animals. Possible epigenetic mechanisms of these effects are considered, as well as their significance as components of genetic factors of radiation risk for humans.
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D000818:Animals; D044127:Epigenesis, Genetic / Q000187:drug effects / Q000528:radiation effects; D016678:Genome / Q000187:drug effects / Q000235:genetics* / Q000528:radiation effects; D042822:Genomic Instability / Q000187:drug effects / Q000235:genetics* / Q000528:radiation effects; D006801:Humans; D009153:Mutagens / Q000633:toxicity; D009381:Neoplasms, Radiation-Induced / Q000235:genetics*; D011839:Radiation, Ionizing
D009153:Mutagens