Myelodysplastic syndrome complicated with inflammatory intestinal ulcers: significance of trisomy 8.
Three cases of myelodysplastic syndrome (MDS) complicated with inflammatory intestinal ulcers all had cytogenetic abnormalities with trisomy 8. The first two patients were diagnosed with intestinal Behçets disease and were successfully treated with salazosulphapiridine, and the third patient died after leukemic transformation. We review the reported cases of MDS complicated with Behçets disease. Most of these cases are Japanese, having intestinal involvement as well as cytogenetic abnormalities with trisomy 8. We discuss the significance of trisomy 8 in intestinal involvement in MDS.
Kawabata
Hiroshi
H
Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Sawaki
Toshioki
T
Kawanami
Takafumi
T
Shimoyama
Kumiko
K
Karasawa
Hiromi
H
Fukushima
Toshihiro
T
Masaki
Yasufumi
Y
Ogawa
Noriyoshi
N
Hirose
Yuko
Y
Ozaki
Kazuaki
K
Shimanaka
Koshi
K
Takase
Shujiro
S
Ueno
Hiroshi
H
Umehara
Hisanori
H
D000368:Aged; D001528:Behcet Syndrome / Q000150:complications; D001853:Bone Marrow / Q000473:pathology; D002898:Chromosomes, Human, Pair 8; D005260:Female; D006801:Humans; D007249:Inflammation / Q000150:complications*; D007410:Intestinal Diseases / Q000150:complications*; D008297:Male; D009190:Myelodysplastic Syndromes / Q000150:complications* / Q000235:genetics* / Q000473:pathology; D014314:Trisomy; D014456:Ulcer / Q000150:complications*