Improving neglect by TMS.
Hemispatial neglect refers to the defective ability of patients to explore or act upon the side of space contralateral to the lesion and to attend to stimuli presented in that portion of space. Evidence from animal models suggests that many of the behavioural sequelae associated with visual neglect may result not solely from the size of the lesion, but also from a pathological state of increased inhibition exerted on the damaged hemisphere by the contralesional hemisphere. On the basis of these potential mechanisms underlying neglect, in this review we discuss therapeutic approaches, focusing particularly on recent research using transcranial magnetic stimulation (TMS). This technique, besides representing an ideal tool to investigate visuo-spatial attentive mechanisms in humans, has shown promising beneficial effects that might have an impact on clinical practice.
Fierro
Brigida
B
Dipartimento di Neurologia, Oftalmologia, Otorinolaringoiatria e Psichiatria, University of Palermo, Palermo, Italy.
Brighina
Filippo
F
Bisiach
Edoardo
E
D000818:Animals; D001288:Attention / Q000502:physiology; D001921:Brain / Q000473:pathology / Q000503:physiopathology*; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D008279:Magnetic Resonance Imaging; D009433:Neural Inhibition / Q000502:physiology; D010468:Perceptual Disorders / Q000175:diagnosis / Q000503:physiopathology* / Q000628:therapy*; D013028:Space Perception / Q000502:physiology; D050781:Transcranial Magnetic Stimulation / Q000379:methods*; D016896:Treatment Outcome; D014796:Visual Perception / Q000502:physiology