title: Prospective evaluation of quality of life and sexual functioning after laparoscopic total mesorectal excision.
abstract: OBJECTIVE
  This study was designed to investigate how the quality of life of patients with rectal cancer changes with time after laparoscopic total mesorectal excision.
  
  
  METHODS
  Patients completed the Medical Outcomes Study Short Form 36 and the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire and a colorectal-specific European Organisation for Research and Treatment of Cancer quality of life questionnaire before laparoscopic total mesorectal excision, on discharge from the hospital and at 3, 6, and 12 months postoperatively. Patients were treated by laparoscopic low anterior resection or laparoscopic abdominoperineal resection.
  
  
  RESULTS
  Fifty-one patients (mean age, 64 years; 29 males (57 percent)) participated in this study, of whom 38 (75 percent) underwent laparoscopic low anterior resection and 13 (25 percent) laparoscopic abdominoperineal resection. Compared with preoperative scores on the Medical Outcomes Study Short Form 36, patients reported a deterioration in physical functioning (74 vs. 80; P = 0.009), and improved mental functioning (76 vs. 70; P = 0.007) at three months. Improvement in emotional well-being was reported both on the Medical Outcomes Study Short Form 36 (78 vs. 53; P = 0.006) and the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire (84 vs. 69; P < 0.001). At one year, improvements in global quality of life (82 vs. 68; P = 0.001) and symptoms, such as fatigue (18 vs. 32; P < 0.001), pain (5 vs. 12; P = 0.009), and appetite loss (3 vs. 13; P = 0.01), were reported. Sexual functioning was worse from three months onward until one year after surgery (47 vs. 66; P = 0.004). Patients who underwent low anterior resection experienced less sexual dysfunction than patients after abdominoperineal resection (21 vs. 56; P = 0.004).
  
  
  CONCLUSIONS
  One year after laparoscopic total mesorectal excision for rectal cancer, patients reported improvement in some important quality of life outcomes, including global quality of life, despite a decrease in sexual functioning.
authors.affiliation: Department of Surgery, University Medical Center Groningen, University of Groningen, Postbus 30001, 9700 RB, Groningen, The Netherlands. sbreukink@msn.com
authors.forename: S O
authors.initials: SO
authors.lastname: Breukink
authors.forename: H J
authors.initials: HJ
authors.lastname: van der Zaag-Loonen
authors.forename: E M C
authors.initials: EM
authors.lastname: Bouma
authors.forename: J P E N
authors.initials: JP
authors.lastname: Pierie
authors.forename: C
authors.initials: C
authors.lastname: Hoff
authors.forename: T
authors.initials: T
authors.lastname: Wiggers
authors.forename: W J H J
authors.initials: WJ
authors.lastname: Meijerink
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D010535:Laparoscopy; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011788:Quality of Life; D012004:Rectal Neoplasms / Q000523:psychology* / Q000601:surgery*; D012735:Sexual Dysfunction, Physiological / Q000209:etiology*; D020018:Sexual Dysfunctions, Psychological / Q000209:etiology*; D018709:Statistics, Nonparametric; D011795:Surveys and Questionnaires; D016896:Treatment Outcome