Chemical synthesis of RNA including 5-taurinomethyluridine.
Recently, a novel base-modified uridine derivative, 5-taurinomethyluridine (taum(5)U) was discovered from bovine and human mitochondrial tRNAs, and this modified ribonucleoside was found to existed at the first position of the anti-codon. We report efficient reactions for the synthesis of RNA oligomers including this base-modified ribonucleotide.
Ogata
Toshihiko
T
Department of Medical Genome Sciences, Graduate School of Frontier Sciences, The Universitiy of Tokyo, Bioscience Bldg 702, Kashiwa, Chiba 277-8562, Japan.
Wada
Takeshi
T
D009843:Oligoribonucleotides / Q000138:chemical synthesis* / Q000737:chemistry; D009943:Organophosphorus Compounds / Q000138:chemical synthesis / Q000737:chemistry; D012313:RNA / Q000138:chemical synthesis* / Q000737:chemistry; D000077278:RNA, Mitochondrial; D012343:RNA, Transfer / Q000737:chemistry; D014529:Uridine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry
C522070:5-taurinomethyluridine; D009843:Oligoribonucleotides; D009943:Organophosphorus Compounds; D000077278:RNA, Mitochondrial; C434331:phosphoramidite; D012313:RNA; D012343:RNA, Transfer; D014529:Uridine