title: [New poly-(3-hydroxybutyrate)-based systems for controlled release of dipyridamole and indomethacin].
abstract: New poly-(3-hydroxybutyrate)-based systems for controlled release of anti-inflammatory and antithrombogenic drugs have been studied. The release occurs via two mechanisms (diffusion and degradation) operating simultaneously. Dipyridamole and indomethacin diffusion processes determine the rate of the release at the early stages of the contact of the system with the environment (the first 6-8 days). The coefficient of the release diffusion of a drug depends on its nature, the thickness of the poly-(3-hydroxybutyrate) films containing the drug, the concentrations of dipyridamole and indomethacin, and the molecular weight of the poly-(3-hydroxybutyrate). The results obtained are critical for developing systems of release of diverse drugs, thus, enabling the attainment of the requisite physiological effects on tissues and organs of humans.
authors.forename: A P
authors.initials: AP
authors.lastname: Bonartsev
authors.forename: G A
authors.initials: GA
authors.lastname: Bonartseva
authors.forename: T K
authors.initials: TK
authors.lastname: Makhina
authors.forename: V L
authors.initials: VL
authors.lastname: Mashkina
authors.forename: E S
authors.initials: ES
authors.lastname: Luchinina
authors.forename: V A
authors.initials: VA
authors.lastname: Livshits
authors.forename: A P
authors.initials: AP
authors.lastname: Boskhomdzhiev
authors.forename: V S
authors.initials: VS
authors.lastname: Markin
authors.forename: A L
authors.initials: AL
authors.lastname: Iordanskiĭ
mesh_terms: D001395:Azotobacter / Q000235:genetics / Q000254:growth & development* / Q000378:metabolism; D003692:Delayed-Action Preparations; D004058:Diffusion; D004176:Dipyridamole / Q000008:administration & dosage / Q000378:metabolism*; D006885:Hydroxybutyrates / Q000737:chemistry / Q000378:metabolism*; D007213:Indomethacin / Q000008:administration & dosage / Q000378:metabolism*; D007218:Industrial Microbiology / Q000379:methods*; D007700:Kinetics; D008970:Molecular Weight; D011091:Polyesters / Q000737:chemistry / Q000378:metabolism*; D011108:Polymers / Q000737:chemistry / Q000378:metabolism; D000094122:Polyhydroxybutyrates
chemical_list: D003692:Delayed-Action Preparations; D004176:Dipyridamole; D006885:Hydroxybutyrates; D007213:Indomethacin; D011091:Polyesters; D011108:Polymers; C003182:poly-beta-hydroxybutyrate; D000094122:Polyhydroxybutyrates