Intravaginal administration of an inactivated vaccine prevents lesions induced by caprine herpesvirus-1 in goats.
To evaluate the efficacy of mucosal vaccination with a beta-propiolactone inactivated caprine herpesvirus-1 (CpHV-1) vaccine, goats received vaginal administrations of two 7-day cycles at 2 weeks intervals. Seven days after the end of the second cycle, goats were challenged intravaginally with 4 ml of virulent BA.1 strain of CpHV-1. Vaccinated goats shed challenge virus for 8 days but, in comparison with control unvaccinated-challenged goats, were significantly protected from the classical clinical signs of genital lesions. Even without adjuvants, prolonged mucosal vaccination induced production of secretory IgA and provided significant clinical protection.
Camero
Michele
M
Department of Animal Health and Well-being, Faculty of Veterinary Medicine, University of Bari, Strada P.le per Casamassima km 3, 70010 Valenzano, Italy.
Bellacicco
Anna Lucia
AL
Tarsitano
Elvira
E
Decaro
Nicola
N
Martella
Vito
V
Tempesta
Maria
M
Buonavoglia
Canio
C
D000282:Administration, Intravaginal; D000818:Animals; D000914:Antibodies, Viral / Q000378:metabolism; D002460:Cell Line; D005260:Female; D015511:Goat Diseases / Q000276:immunology / Q000517:prevention & control* / Q000821:virology; D006041:Goats; D006566:Herpesviridae Infections / Q000276:immunology / Q000517:prevention & control / Q000662:veterinary*; D022283:Herpesvirus Vaccines / Q000008:administration & dosage / Q000276:immunology*; D018928:Immunity, Mucosal; D007071:Immunoglobulin A, Secretory / Q000378:metabolism; D015164:Vaccines, Inactivated / Q000008:administration & dosage / Q000276:immunology*; D018140:Varicellovirus / Q000276:immunology* / Q000472:pathogenicity
D000914:Antibodies, Viral; D022283:Herpesvirus Vaccines; D007071:Immunoglobulin A, Secretory; D015164:Vaccines, Inactivated