[Rofecoxib-induced psychosis].
Acute psychosis is a possible side effect of many centrally acting drugs. Its appearance is facilitated by certain conditions like advanced age, comedication, or comorbidity. We report two cases of acute psychotic syndromes with visual (Case 1 + 2) and auditory (Case 1) hallucinations under rofecoxib, a cyclooxygenase-2-inhibitor. This is one of the first reports of psychotic disorders under rofecoxib intake. We present a review of the literature on mental side effects of NSAID and on the pharmacological basis of the association of cyclooxygenase-inhibitors and mental disorders.
Sabolek
Michael
M
Neurologische Klinik der Universität Ulm (Direktor: Prof. Dr. med. A. C. Ludolph). michael.sabolek@uni-ulm.de
Unrath
Alexander
A
Sperfeld
Anne-Dorte
AD
Connemann
Bernhard J
BJ
Kassubek
Jan
J
D000368:Aged; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D016861:Cyclooxygenase Inhibitors / Q000627:therapeutic use / Q000633:toxicity*; D005260:Female; D005500:Follow-Up Studies; D006212:Hallucinations / Q000139:chemically induced* / Q000175:diagnosis; D006801:Humans; D007783:Lactones / Q000627:therapeutic use / Q000633:toxicity*; D008297:Male; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000188:drug therapy*; D011605:Psychoses, Substance-Induced / Q000175:diagnosis / Q000209:etiology*; D012075:Remission, Spontaneous; D013450:Sulfones / Q000627:therapeutic use / Q000633:toxicity*
D016861:Cyclooxygenase Inhibitors; D007783:Lactones; D013450:Sulfones; C116926:rofecoxib