Expression of semaphorin 6D in gastric carcinoma and its significance.
OBJECTIVE
To investigate the protein and mRNA expression of semaphorin 6D in gastric carcinoma and its significance.


METHODS
The protein and mRNA expression of semaphorin 6D was detected by semi-quantitative reverse transcription PCR and Western blotting respectively in 30 cases of gastric carcinoma and normal gastric mucosa.


RESULTS
The protein and mRNA expression of semaphorin 6D in gastric carcinoma was significantly higher than that in normal gastric mucosa (0.24 +/- 0.06 vs 0.19 +/- 0.07, 0.26 +/- 0.09 vs 0.20 +/- 0.10, P < 0.05).


CONCLUSIONS
Semaphorin 6D may play an important role in the occurrence and development of gastric carcinoma, and is related to tumor angiogenesis.
Zhao
Xiang-Yang
XY
Department of General Surgery, General Hospital of Chinese PLA, 28 Fuxing Road, Beijing 100853, China.
Chen
Lin
L
Xu
Qian
Q
Li
Yu-Hong
YH
D000328:Adult; D000368:Aged; D002454:Cell Differentiation; D005260:Female; D005753:Gastric Mucosa / Q000473:pathology*; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008297:Male; D008875:Middle Aged; D009389:Neovascularization, Pathologic / Q000235:genetics; D012333:RNA, Messenger / Q000235:genetics; D012334:RNA, Neoplasm / Q000235:genetics; D039961:Semaphorins / Q000235:genetics*; D013274:Stomach Neoplasms / Q000235:genetics* / Q000473:pathology / Q000601:surgery
D012333:RNA, Messenger; D012334:RNA, Neoplasm; D039961:Semaphorins