Synthesis of protein-polymer conjugates.
Protein-polymer conjugates are widely employed for applications in medicine, biotechnology and nanotechnology. Covalent attachment of synthetic polymers to proteins improves protein stability, solubility, and biocompatibility. Furthermore, synthetic polymers impart new properties such as self assembly and phase behavior. Polymer attachment at amino acid side-chains and at ligand binding sites is typically exploited. This Emerging Area focuses on synthetic methods to prepare protein-reactive polymers and also employing the protein itself as an initiator for polymerization.
Heredia
Karina L
KL
Department of Chemistry and Biochemistry and the California NanoSystems Institute, University of California, Los Angeles, 607 Charles E. Young Drive East, Los Angeles, CA 90095-1569, USA.
Maynard
Heather D
HD
D001672:Biocompatible Materials / Q000138:chemical synthesis*; D046911:Macromolecular Substances / Q000138:chemical synthesis*; D008958:Models, Molecular; D015394:Molecular Structure; D036103:Nanotechnology; D010091:Oximes / Q000737:chemistry; D011108:Polymers / Q000138:chemical synthesis* / Q000378:metabolism; D011506:Proteins / Q000138:chemical synthesis* / Q000378:metabolism; D013438:Sulfhydryl Compounds / Q000737:chemistry
D001672:Biocompatible Materials; D046911:Macromolecular Substances; D010091:Oximes; D011108:Polymers; D011506:Proteins; D013438:Sulfhydryl Compounds