[The structure and regulation of emzymes of thyroid hormonopoesis].
The review is devoted to peculiarities of structure, regulation and interaction of enzyme systems of thyroid hormone synthesis. The structural and functional differences between enzymes of the thyroid gland, and nonthyroid homologues making a family of enzymes are considered. The contribution of various signal systems, including those related to generation of oxygen forms, to regulation of the thyroid hormone synthesis estimates. A problem on influence of the oxidation-reduction status of thyroid cells on their functional activity is also discussed. The role of disregulation of separate parts of thyroid hormonopoesis in pathogenesis of thyroid disease is marked.
Kavok
N S
NS
D000818:Animals; D001692:Biological Transport; D006801:Humans; D006861:Hydrogen Peroxide / Q000378:metabolism; D007453:Iodide Peroxidase / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D007455:Iodine / Q000378:metabolism; D019255:NADPH Oxidases / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D027981:Symporters / Q000378:metabolism; D013961:Thyroid Gland / Q000201:enzymology / Q000276:immunology / Q000378:metabolism; D013963:Thyroid Hormones / Q000096:biosynthesis* / Q000737:chemistry / Q000235:genetics; D000099209:Sodium-Iodide Symporters
D006861:Hydrogen Peroxide; D007453:Iodide Peroxidase; D007455:Iodine; D019255:NADPH Oxidases; D027981:Symporters; D013963:Thyroid Hormones; D000099209:Sodium-Iodide Symporters