title: Positive correlation between pigment epithelium-derived factor and monocyte chemoattractant protein-1 levels in the aqueous humour of patients with uveitis.
abstract: OBJECTIVE
  To evaluate whether aqueous humour levels of pigment epithelium-derived factor (PEDF) are associated with monocyte chemoattractant protein-1 (MCP-1) in patients with uveitis.
  
  
  METHODS
  Aqueous humour levels of MCP-1 and PEDF were determined by ELISA in 34 uveitis samples and 9 cataract control samples.
  
  
  RESULTS
  Aqueous humour MCP-1 and PEDF levels were significantly higher in patients with infectious or non-infectious uveitis than in controls (mean (SD) 32.3 (10.7) ng/ml vs 4.48 (1.10) ng/ml vs 0.47 (0.10) ng/ml, and 8.40 (1.30) microg/ml vs 5.01 (0.92) microg/ml vs 1.32 (0.22) microg/ml, respectively, p<0.001). A positive correlation between PEDF and MCP-1 was found in patients with uveitis (r = 0.39, p<0.01).
  
  
  CONCLUSIONS
  The results demonstrated that aqueous humour levels of PEDF were positively associated with MCP-1 in patients with uveitis. The present observations suggest that aqueous humour levels of PEDF may be a marker of inflammation in uveitis.
authors.affiliation: Department of Medicine, Division of Cardiovascular Medicine, Kurume University School of Medicine, Kurume 830-0011, Japan.
authors.forename: Yumiko
authors.initials: Y
authors.lastname: Yoshida
authors.forename: Sho-Ichi
authors.initials: S
authors.lastname: Yamagishi
authors.forename: Takanori
authors.initials: T
authors.lastname: Matsui
authors.forename: Kazuo
authors.initials: K
authors.lastname: Nakamura
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Imaizumi
authors.forename: Koichi
authors.initials: K
authors.lastname: Yoshimura
authors.forename: Ryoji
authors.initials: R
authors.lastname: Yamakawa
mesh_terms: D000368:Aged; D001082:Aqueous Humor / Q000737:chemistry*; D015415:Biomarkers / Q000032:analysis; D002386:Cataract / Q000378:metabolism; D018932:Chemokine CCL2 / Q000032:analysis*; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D015817:Eye Infections / Q000378:metabolism; D005136:Eye Proteins / Q000032:analysis*; D006801:Humans; D008875:Middle Aged; D009414:Nerve Growth Factors / Q000032:analysis*; D015843:Serpins / Q000032:analysis*; D014605:Uveitis / Q000378:metabolism*; D000099174:Pigment Epithelium-Derived Factor
chemical_list: D015415:Biomarkers; D018932:Chemokine CCL2; D005136:Eye Proteins; D009414:Nerve Growth Factors; D015843:Serpins; D000099174:Pigment Epithelium-Derived Factor