title: Cost effectiveness of recombinant activated factor VII for the control of bleeding in patients with severe blunt trauma injuries in the United Kingdom.
abstract: The aim of this study was to assess the lifetime cost effectiveness of recombinant activated factor VII vs placebo as adjunctive therapy for control of bleeding in patients with severe blunt trauma in the UK. We developed a cost-effectiveness model based on patient level data from a 30-day international, randomised, placebo-controlled Phase II trial. The data were supplemented with secondary data from UK sources to estimate lifetime costs and benefits. The model produced a baseline estimate of the incremental cost per life year gained with recombinant activated factor VII relative to placebo of 12 613 UK pounds. The incremental cost per quality adjusted life year gained was 18 825 UK pounds. These estimates are sensitive to the choice of discount rate and health state utility values used. Preliminary results suggest that relative to placebo, recombinant activated factor VII may be a cost-effective therapy to the UK National Health Service.
authors.affiliation: Health Economics Research Group, Brunel University, Uxbridge, Middlesex UB8 3PH, UK.
authors.forename: S
authors.initials: S
authors.lastname: Morris
authors.forename: S
authors.initials: S
authors.lastname: Ridley
authors.forename: V
authors.initials: V
authors.lastname: Munro
authors.forename: M C
authors.initials: MC
authors.lastname: Christensen
mesh_terms: D000328:Adult; D017322:Clinical Trials, Phase II as Topic; D015331:Cohort Studies; D003362:Cost-Benefit Analysis; D005167:Factor VII / Q000191:economics / Q000627:therapeutic use*; D015942:Factor VIIa; D005260:Female; D017048:Health Care Costs; D006470:Hemorrhage / Q000209:etiology / Q000401:mortality / Q000517:prevention & control*; D006801:Humans; D008297:Male; D018803:Models, Economic; D019057:Quality-Adjusted Life Years; D016032:Randomized Controlled Trials as Topic; D011994:Recombinant Proteins / Q000191:economics / Q000627:therapeutic use; D013222:State Medicine; D016019:Survival Analysis; D006113:United Kingdom / Q000453:epidemiology; D014949:Wounds, Nonpenetrating / Q000150:complications* / Q000191:economics / Q000401:mortality
chemical_list: D011994:Recombinant Proteins; D005167:Factor VII; C103587:recombinant FVIIa; D015942:Factor VIIa