Hyperoxia attenuates endothelial-mediated vasodilation in the human skin.
The influence of hyperoxia on the cutaneous vasodilator responses to iontophoretic applications of acetylcholine (ACh) and sodium nitroprusside (SNP) was examined in healthy subjects. The breathing of 100% O(2) decreased (P < 0.05) the vasodilator response to Ach, but not to SNP, suggesting that hyperoxia attenuates endothelial-mediated vasodilation of the human skin.
Yamazaki
Fumio
F
Department of Clinical Pathophysiology, School of Health Sciences, University of Occupational and Environmental Health, Kitakyushu, 807-8555 Japan. yamazaki@health.uoeh-u.ac.jp
D000109:Acetylcholine / Q000008:administration & dosage; D000279:Administration, Cutaneous; D000328:Adult; D001783:Blood Flow Velocity; D004730:Endothelium, Vascular / Q000503:physiopathology*; D006801:Humans; D018496:Hyperoxia / Q000503:physiopathology*; D007478:Iontophoresis; D017078:Laser-Doppler Flowmetry; D008297:Male; D008833:Microcirculation; D009599:Nitroprusside / Q000008:administration & dosage; D012867:Skin / Q000098:blood supply*; D013997:Time Factors; D014664:Vasodilation / Q000187:drug effects; D014665:Vasodilator Agents / Q000008:administration & dosage
D014665:Vasodilator Agents; D009599:Nitroprusside; D000109:Acetylcholine