title: Importance of diet in protection against oxidative damage.
abstract: OBJECTIVE
  In humans, epidemiological evidence suggests that increased consumption of fruits and vegetables can substantially enhance the protection against many common types of cancer.
  
  
  RESULTS
  A molecular epidemiological study in 3 Slovak factories producing asbestos, glass fibres and rockwool was conducted. Altogether 388 subjects (239 exposed, 148 controls) were investigated. Food frequency questionnaire was used to ascertain nutrient intake and compared to plasma levels of selected micronutrients, as well as to markers of oxidative stress (MDA, oxidative DNA damage and DNA repair) and antioxidant protection. We found a negative correlation between MDA concentrations and consumption of fruits (p=0.05) and vegetables (p=0.05) in all control subjects. Intake of fruits (p=0.05), vegetables (p=0.01), milk (p=0.01) and cereals (p=0.05) inversely correlated with oxidative DNA damage (net FPG) in all subjects investigated. There was a negative correlation between the intake of fruits (p=0.05) and vegetables (p=0.01) in all exposed subjects.
  
  
  CONCLUSIONS
  Our results suggest that well balanced food consumption with higher fruits and vegetables intake has a protective effect against oxidative damage.
authors.affiliation: Research Base of Slovak Medical University, Bratislava, Slovakia. marta.staruchova@szu.sk
authors.forename: Marta
authors.initials: M
authors.lastname: Staruchová
authors.forename: Katarína
authors.initials: K
authors.lastname: Volková
authors.forename: Alica
authors.initials: A
authors.lastname: Lajdová
authors.forename: Csilla
authors.initials: C
authors.lastname: Misl'anová
authors.forename: Andrew
authors.initials: A
authors.lastname: Collins
authors.forename: Ladislava
authors.initials: L
authors.lastname: Wsólová
authors.forename: Ladislav
authors.initials: L
authors.lastname: Staruch
authors.forename: Mária
authors.initials: M
authors.lastname: Dusinská
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004249:DNA Damage; D004032:Diet; D005260:Female; D005638:Fruit; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D019016:Mineral Fibers / Q000633:toxicity; D009784:Occupational Diseases / Q000517:prevention & control; D018384:Oxidative Stress; D014675:Vegetables; D014815:Vitamins / Q000097:blood
chemical_list: D019016:Mineral Fibers; D014815:Vitamins; D008315:Malondialdehyde