euHCVdb: the European hepatitis C virus database.
The hepatitis C virus (HCV) genome shows remarkable sequence variability, leading to the classification of at least six major genotypes, numerous subtypes and a myriad of quasispecies within a given host. A database allowing researchers to investigate the genetic and structural variability of all available HCV sequences is an essential tool for studies on the molecular virology and pathogenesis of hepatitis C as well as drug design and vaccine development. We describe here the European Hepatitis C Virus Database (euHCVdb, http://euhcvdb.ibcp.fr), a collection of computer-annotated sequences based on reference genomes. The annotations include genome mapping of sequences, use of recommended nomenclature, subtyping as well as three-dimensional (3D) molecular models of proteins. A WWW interface has been developed to facilitate database searches and the export of data for sequence and structure analyses. As part of an international collaborative effort with the US and Japanese databases, the European HCV Database (euHCVdb) is mainly dedicated to HCV protein sequences, 3D structures and functional analyses.
Combet
Christophe
C
Institut de Biologie et Chimie des Protéines (UMR5086), CNRS, University of Lyon 1, IFR 128 BioSciences, Lyon-Gerland, France. c.combet@ibcp.fr
Garnier
Nicolas
N
Charavay
Céline
C
Grando
Delphine
D
Crisan
Daniel
D
Lopez
Julien
J
Dehne-Garcia
Alexandre
A
Geourjon
Christophe
C
Bettler
Emmanuel
E
Hulo
Chantal
C
Le Mercier
Philippe
P
Bartenschlager
Ralf
R
Diepolder
Helmut
H
Moradpour
Darius
D
Pawlotsky
Jean-Michel
JM
Rice
Charles M
CM
Trépo
Christian
C
Penin
François
F
Deléage
Gilbert
G
D030562:Databases, Protein; D016679:Genome, Viral; D023281:Genomics; D016174:Hepacivirus / Q000235:genetics*; D020407:Internet; D008958:Models, Molecular; D011487:Protein Conformation; D020539:Sequence Analysis, Protein; D014584:User-Computer Interface; D014764:Viral Proteins / Q000737:chemistry* / Q000235:genetics*
D014764:Viral Proteins