Synthesis and alternate-stranded triplex forming ability of novel alpha-beta chimeric oligonucleotides bearing an intercalator-conjugated nucleobase.
A series of novel alpha-beta chimeric oligonucleotides bearing anthraquinone-attached nucleobase at linker position, were synthesized as a triplex-forming oligonucleotide (TFO). Their ability to stabilize the alternate-stranded triple helix was investigated through the UV-melting experiments.
Azam
A T M Zafrul
AT
Department of Chemistry, Faculty of Engineering, Gunma University, 1-5-1 Tenjin-cho, Kiryu 376-8515, Japan.
Hasegawa
Minoru
M
Moriguchi
Tomohisa
T
Shinozuka
Kazuo
K
D001483:Base Sequence; D004247:DNA / Q000138:chemical synthesis* / Q000528:radiation effects; D003841:Deoxycytidine / Q000031:analogs & derivatives* / Q000737:chemistry; D007364:Intercalating Agents / Q000494:pharmacology*; D008969:Molecular Sequence Data; D009690:Nucleic Acid Conformation / Q000187:drug effects* / Q000528:radiation effects; D009691:Nucleic Acid Denaturation / Q000187:drug effects / Q000528:radiation effects; D009841:Oligonucleotides / Q000138:chemical synthesis* / Q000737:chemistry*; D014466:Ultraviolet Rays
D007364:Intercalating Agents; D009841:Oligonucleotides; C051802:triplex DNA; D003841:Deoxycytidine; D004247:DNA; C016569:5-methyldeoxycytidine