Interleukin-2 concentration in hypothalamic structures of rats receiving peptides during mild stress.
The number of hypothalamic IL-2-containing cells changed in rats receiving Vilon and Epithalon during mild stress (handling). The number of IL-2-positive cells in hypothalamic structures decreased 24 h after intramuscular injection of Epithalon and 2 h after intranasal administration of the test peptides. Adaptation of animals to experimental conditions prevented the decrease in the number of IL-2-positive cells in the supraoptic nucleus after intranasal administration of Epithalon.
Barabanova
S V
SV
Department of General Pathology and Pathophysiology, Institute of Experimental Medicine, Russian Academy of Medical Sciences, St. Petersburg.
Artyukhina
Z E
ZE
Kazakova
T B
TB
Khavinson
V Kh
VKh
Malinin
V V
VV
Korneva
E A
EA
D000818:Animals; D004151:Dipeptides / Q000494:pharmacology*; D007031:Hypothalamus / Q000378:metabolism*; D007376:Interleukin-2 / Q000096:biosynthesis* / Q000378:metabolism; D008297:Male; D009842:Oligopeptides / Q000494:pharmacology*; D010455:Peptides / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013312:Stress, Physiological; D013997:Time Factors
D004151:Dipeptides; D007376:Interleukin-2; D009842:Oligopeptides; D010455:Peptides; C415909:lysylglutamic acid; C421253:alanyl-glutamyl-aspartyl-glycine