title: Rheumatoid nodulosis during methotrexate therapy in a patient with rheumatoid arthritis.
abstract: We report a 62-year-old man with rheumatoid arthritis (RA) who developed nodulosis after methotrexate (MTX) treatment. The epithelioid cells of nodules were positive for matrix metalloproteinases (MMP)-2, MMP-3, MMP-9, and Ki67. The synovial tissues obtained from the same patient were negative for MMP-3, MMP-9, and Ki67. This study demonstrated that MTX-induced nodules are different from synovial tissues in terms of MMP expression, suggesting the presence of different pathologic mechanisms and differential MTX susceptibility.
authors.affiliation: Department of Orthopaedic Surgery, Faculty of Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan. matusita@med.u-toyama.ac.jp
authors.forename: Isao
authors.initials: I
authors.lastname: Matsushita
authors.forename: Miwa
authors.initials: M
authors.lastname: Uzuki
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Matsuno
authors.forename: Eiji
authors.initials: E
authors.lastname: Sugiyama
authors.forename: Tomoastu
authors.initials: T
authors.lastname: Kimura
mesh_terms: D018501:Antirheumatic Agents / Q000009:adverse effects*; D001172:Arthritis, Rheumatoid / Q000378:metabolism / Q000473:pathology*; D015415:Biomarkers / Q000378:metabolism; D015622:Epithelioid Cells / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000378:metabolism; D008297:Male; D020782:Matrix Metalloproteinases / Q000378:metabolism; D008727:Methotrexate / Q000009:adverse effects*; D008875:Middle Aged; D012218:Rheumatoid Nodule / Q000139:chemically induced / Q000378:metabolism / Q000473:pathology*; D013583:Synovial Membrane / Q000187:drug effects / Q000378:metabolism / Q000473:pathology
chemical_list: D018501:Antirheumatic Agents; D015415:Biomarkers; D019394:Ki-67 Antigen; D020782:Matrix Metalloproteinases; D008727:Methotrexate