Waltzing transporters and 'the dance macabre' between humans and bacteria.
Multidrug-resistance efflux pumps - in particular those belonging to the resistance-nodulation-cell-division (RND) family of transporters, with their unusually high degree of substrate promiscuity - significantly restrict the effectiveness of antibacterial therapy. Recent years have heralded remarkable insights into the structure and mechanisms of these fascinating molecular machines. Here, we review recent advances in the field and describe various approaches used in combating efflux-mediated resistance.
Lomovskaya
Olga
O
Mpex Pharmaceuticals, Inc. 3030 Bunker Hill Street, Suite 200 San Diego, California 92109, USA. olomovskaya@mpexpharma.com
Zgurskaya
Helen I
HI
Totrov
Maxim
M
Watkins
William J
WJ
D018435:ATP Binding Cassette Transporter, Subfamily B / Q000378:metabolism*; D000900:Anti-Bacterial Agents / Q000378:metabolism* / Q000627:therapeutic use; D001419:Bacteria / Q000187:drug effects* / Q000378:metabolism*; D001424:Bacterial Infections / Q000188:drug therapy / Q000382:microbiology; D002352:Carrier Proteins / Q000378:metabolism*; D024881:Drug Resistance, Bacterial / Q000502:physiology; D006801:Humans
D018435:ATP Binding Cassette Transporter, Subfamily B; D000900:Anti-Bacterial Agents; D002352:Carrier Proteins