[Effective therapy with a glycine-proline ointment in a patient with recurrent ulcers from prolidase deficiency].
BACKGROUND
Prolidase deficiency is a rare disease. Lower leg recalcitrant ulcerations are the most characteristic symptoms.


METHODS
Woman diagnosed of prolidase deficiency with leg recalcitrant and infected ulcerations. Dermatology service solicits a proline and glycline containing ointment after failing other topical treatment and a skin grafting. After initiation of treatment, ulcerations improved partially. FORMULA DESCRIPTION: According to "Real Decreto 175/2001, de 23 de febrero", Pharmacy service draws up an elaboration guide and a patient information leaflet of a proline 5%-glycine 5% water emulsive ointment.


CONCLUSIONS
Topical application of a glycine-proline ointment is an alternative for the treatment of recalcitrant ulcerations and it has resulted in variable response. In our patient it has been effective, with a partial improvement of leg ulcerations and a decrease in admissions due to over infection.
Ortega García
M P
MP
Servicio de Farmacia, Consorcio Hospital General Universitario, Valencia. ortega_mpi@gva.es
Cánoves Escolano
M A
MA
Blasco Segura
P
P
García Melgares
M L
ML
D000287:Administration, Topical; D000592:Amino Acid Metabolism, Inborn Errors / Q000188:drug therapy* / Q000201:enzymology; D004150:Dipeptidases / Q000172:deficiency*; D005260:Female; D005998:Glycine / Q000378:metabolism / Q000627:therapeutic use*; D006801:Humans; D007871:Leg Ulcer / Q000188:drug therapy / Q000201:enzymology; D008875:Middle Aged; D009824:Ointments / Q000008:administration & dosage; D011392:Proline / Q000378:metabolism / Q000627:therapeutic use*; D055502:Secondary Prevention; D016896:Treatment Outcome
D009824:Ointments; D011392:Proline; D004150:Dipeptidases; C022449:proline dipeptidase; D005998:Glycine