Overnight urinary cortisol release in women with borderline personality disorder depends on comorbid PTSD and depressive psychopathology.
Free cortisol was investigated in BPD patients and healthy controls. A positive association was found between cortisol and depression scores, while the number of PTSD symptoms was negatively correlated with cortisol release. These findings suggest that alterations in cortisol release in BPD are strongly associated with the severity of psychopathology.
Wingenfeld
Katja
K
Department of Psychiatry and Psychotherapy Bethel, Ev. Hospital Bielefeld, Remterweg 69-71, D-33617 Bielefeld, Germany. katja.wingenfeld@evkb.de
Driessen
Martin
M
Adam
Bettina
B
Hill
Andreas
A
D000328:Adult; D001883:Borderline Personality Disorder / Q000175:diagnosis / Q000523:psychology / Q000652:urine*; D002648:Child; D002649:Child Abuse / Q000523:psychology; D002940:Circadian Rhythm / Q000502:physiology*; D015897:Comorbidity; D003866:Depressive Disorder / Q000175:diagnosis / Q000523:psychology / Q000652:urine*; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000652:urine*; D008016:Life Change Events; D010552:Personality Assessment; D010555:Personality Inventory; D011599:Psychopathology; D013223:Statistics as Topic; D013313:Stress Disorders, Post-Traumatic / Q000175:diagnosis / Q000523:psychology / Q000652:urine*
D006854:Hydrocortisone