title: Ganglioside-specific IgG and IgA recruit leukocyte effector functions in Guillain-Barré syndrome.
abstract: The capacity of ganglioside-specific autoantibodies to recruit leukocyte effector functions was studied. Serum samples from 87 patients with Guillain-Barré (GBS) or Miller Fisher syndrome (MFS), containing GM1-, GQ1b-, or GD1b-specific IgG or IgA, were tested for leukocyte activating capacity. Ganglioside-specific IgG antibodies generally induced leukocyte activation, irrespective of specificity. The magnitude of leukocyte degranulation correlated with GM1- and GQ1b-specific IgG titers, but not with disease severity. Finally, GM1-specific IgA activated leukocytes through the IgA receptor, FcalphaRI (CD89). Therefore, both ganglioside-specific IgG and IgA can recruit leukocyte effector functions, which may be relevant in the pathogenesis of GBS and MFS.
authors.affiliation: Department of Immunology, University Medical Center Utrecht, Lundlaan 6, 3584 EA Utrecht, The Netherlands.
authors.forename: Nina M
authors.initials: NM
authors.lastname: van Sorge
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Yuki
authors.forename: Michiaki
authors.initials: M
authors.lastname: Koga
authors.forename: Keiichiro
authors.initials: K
authors.lastname: Susuki
authors.forename: Marc D
authors.initials: MD
authors.lastname: Jansen
authors.forename: Cees
authors.initials: C
authors.lastname: van Kooten
authors.forename: John H J
authors.initials: JH
authors.lastname: Wokke
authors.forename: Jan G J
authors.initials: JG
authors.lastname: van de Winkel
authors.forename: W-Ludo
authors.initials: WL
authors.lastname: van der Pol
authors.forename: Leonard H
authors.initials: LH
authors.lastname: van den Berg
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000918:Antibody Specificity; D015703:Antigens, CD / Q000378:metabolism; D001323:Autoantibodies / Q000276:immunology*; D015550:Cell Degranulation; D002648:Child; D002675:Child, Preschool; D005260:Female; D005677:G(M1) Ganglioside / Q000276:immunology; D005732:Gangliosides / Q000276:immunology*; D020275:Guillain-Barre Syndrome / Q000097:blood / Q000276:immunology*; D006801:Humans; D007070:Immunoglobulin A / Q000276:immunology*; D007074:Immunoglobulin G / Q000276:immunology*; D007962:Leukocytes / Q000276:immunology* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D019846:Miller Fisher Syndrome / Q000097:blood / Q000276:immunology; D011961:Receptors, Fc / Q000378:metabolism
chemical_list: D015703:Antigens, CD; D001323:Autoantibodies; C036832:Fc(alpha) receptor; D005732:Gangliosides; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D011961:Receptors, Fc; C033851:ganglioside, GD1b; D005677:G(M1) Ganglioside; C039129:GQ1b ganglioside