[Evolution of the bone mass of hypertense menopausal women in treatment with fosinopril].
OBJECTIVE
The renin-angiotensin system (SRA) acts on the bone metabolism and decreases the mineralization. Menopausal women frequently are hypertense and have risk of developing osteoporosis. The inhibition of SRA could favour the mineralization and protect the bone mass of hypertense women in treatment with antihypertensive drugs that are angiotensin converting enzyme inhibitors.


METHODS
Cohorts prospective study. 50 menopausal women were recruited and divided in one cohort of non hypertense patients and one cohort of hypertense women who initiated antihypertensive treatment with oral fosinopril. Baseline and after 1 year bone mineral density of lumbar spine and femoral neck was made.


RESULTS
There were no significant differences between the bone mass of both groups. Significant changes between the baseline and after the treatment were not demonstrated in the cohort exposed. In the group of non exposed women were demonstrated differences in lumbar spine (baseline, 0.874 g/cm(2); final, 0.854 g/cm(2); p = 0.002) and femoral neck (baseline, 0.743 g/cm(2); final, 0.725 g/cm(2); p = 0.016).


CONCLUSIONS
The menopausal and hypertense women who followed treatment with fosinopril did not present the physiological loss of bone mass that affected to menopausal women without treatment.
García-Testal
Alicia
A
Servicio de Nefrología, Hospital Universitario La Fe, Valencia, Spain. testal@ono.com
Monzó
Ana
A
Rabanaque
Gloria
G
González
Antonio
A
Romeu
Alberto
A
D015502:Absorptiometry, Photon; D000328:Adult; D000368:Aged; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D015519:Bone Density / Q000187:drug effects; D015331:Cohort Studies; D005260:Female; D017328:Fosinopril / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D008593:Menopause; D008875:Middle Aged; D011446:Prospective Studies
D000806:Angiotensin-Converting Enzyme Inhibitors; D017328:Fosinopril