[Neutropenia and sepsis in hematologic patients].
BACKGROUND
The neutropenic patient's infections are challenging problems for modern medicine. The increasing number of iatrogenic neutropenia, the invasive procedures and the growing resistance to antibiotics and antimycotics make the treatment of sepsis difficult. The aim of this study was to analyse the frequency and mortality of neutropenic infections in hematologic patients.


RESULTS
In the department of the authors 146 patients with sepsis were diagnosed out of 2173 treated patients in 24 months (67/1000 patients). 78 of them were neutropenic (absolute neutrophil count below 0,5 G/I) and 63 were severe neutropenic (absolute neutrophil count below 0,1 G/I). Sepsis occurred on the 10-11th day of neutropenia. 45% of positive hemoculture were caused by Gram positive bacteria, 30% by Gram negative bacteria, 10% by fungi and 15% were polymicrobic infections. The overall mortality was 36%, but in the severe neutropenic group it was about 60%.


CONCLUSIONS
These results show that despite of the use of new, broad spectrum of antibiotics and antimycotics in neutropenic patients with sepsis, it is difficult to treat these patients.
Egyed
Miklós
M
Kaposi Mór Oktató Kórház, Belgyógyászat-Hematológia, Kaposvár.
Kollár
Balázs
B
Karádi
Eva
E
Rajnics
Péter
P
Kocsondi
Lívia
L
Rumi
György
G
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016470:Bacteremia / Q000453:epidemiology / Q000382:microbiology; D005260:Female; D016469:Fungemia / Q000453:epidemiology / Q000382:microbiology; D016905:Gram-Negative Bacterial Infections / Q000453:epidemiology; D016908:Gram-Positive Bacterial Infections / Q000453:epidemiology; D006402:Hematologic Diseases / Q000150:complications / Q000453:epidemiology; D017052:Hospital Mortality; D006801:Humans; D006814:Hungary / Q000453:epidemiology; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009503:Neutropenia / Q000150:complications* / Q000453:epidemiology* / Q000401:mortality; D018805:Sepsis / Q000453:epidemiology* / Q000209:etiology / Q000382:microbiology* / Q000401:mortality