title: 13C bis-labeled pyrroles: a tool for the identification of the rat metabolism of 3-methyl pyrrole-2,4-dicarboxylic acid 2-propyl ester 4-(1,2,2-trimethyl-propyl) ester.
abstract: Following the recent disclosure of 3-methyl pyrrole-2,4-dicarboxylic acid 2-propyl ester 4-(1,2,2-trimethyl-propyl) ester as a potent and selective mGluR1 non-competitive antagonist, the use of a doubly (13)C-labeled analogue to identify, and consequently prevent, metabolically labile positions is reported.
authors.affiliation: GlaxoSmithKline Medicines Research Centre, Via Fleming 4, 37135 Verona, Italy. Fabrizio.E.Micheli@gsk.com
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Micheli
authors.forename: Paolo
authors.initials: P
authors.lastname: Cavanni
authors.forename: Romano
authors.initials: R
authors.lastname: Di Fabio
authors.forename: Daniele
authors.initials: D
authors.lastname: Donati
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Hamdan
authors.forename: Stefano
authors.initials: S
authors.lastname: Provera
authors.forename: Maria Elvira
authors.initials: ME
authors.lastname: Tranquillini
authors.forename: Giovanni
authors.initials: G
authors.lastname: Vitulli
mesh_terms: D000818:Animals; D002250:Carbon Radioisotopes / Q000737:chemistry; D004952:Esters; D007202:Indicators and Reagents; D007553:Isotope Labeling; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D011758:Pyrroles; D051381:Rats; D018094:Receptors, Metabotropic Glutamate / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship
chemical_list: C481958:3,5-dimethyl pyrrole-2,4-dicarboxylic acid 2-propyl ester 4-(1,2,2-trimethyl-propyl) ester; D002250:Carbon Radioisotopes; D004952:Esters; D007202:Indicators and Reagents; D011758:Pyrroles; D018094:Receptors, Metabotropic Glutamate; C104077:metabotropic glutamate receptor type 1