title: Oral administration of alginic acid oligosaccharide suppresses IgE production and inhibits the induction of oral tolerance.
abstract: We have found that alginic acid oligosaccharide (ALGO) enhanced Th1 by promoting IL-12 production, suggesting that ALGO can be applied as an anti-allergic food. In this study we examined both positive and negative functions of ALGO. First we investigated the anti-allergic activity of ALGO, as a positive function, when orally administered. IgE production was significantly inhibited in mice fed ALGO as compared to control mice. This result indicates that ALGO had anti-allergic activity even when orally administered. On the other hand, we also found a negative function of ALGO. Oral co-administration of a protein antigen and ALGO inhibited the induction of oral tolerance to the protein. These data indicate the potential of ALGO as an anti-allergic food material and the necessity of further examination to determine a safe method application.
authors.affiliation: Department of Applied Biological Science, Tokyo University of Agriculture and Technology.
authors.forename: Tsukasa
authors.initials: T
authors.lastname: Uno
authors.forename: Makoto
authors.initials: M
authors.lastname: Hattori
authors.forename: Tadashi
authors.initials: T
authors.lastname: Yoshida
mesh_terms: D000284:Administration, Oral; D000464:Alginates / Q000008:administration & dosage*; D000818:Animals; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D020723:Glucuronic Acid / Q000008:administration & dosage; D006603:Hexuronic Acids / Q000008:administration & dosage; D007073:Immunoglobulin E / Q000096:biosynthesis*; D018664:Interleukin-12 / Q000096:biosynthesis; D051379:Mice; D008807:Mice, Inbred BALB C; D009844:Oligosaccharides / Q000008:administration & dosage*; D018417:Th1 Cells / Q000187:drug effects* / Q000276:immunology
chemical_list: D000464:Alginates; D006603:Hexuronic Acids; D009844:Oligosaccharides; D018664:Interleukin-12; D007073:Immunoglobulin E; D020723:Glucuronic Acid