Cholesterol, it's not just for heart disease anymore.
Recent studies have shown that cholesterol plays a significant role in the ability of Toxin A from Clostridium difficile to enter eukaryotic cells. The translocation process is one of three major steps during intoxication that could be targeted for intervention against the severe antibiotic-associated diarrhea caused by C. difficile.
Kerzmann
Amy
A
Department of Chemistry, Indiana University, 800 East Kirkwood Avenue, Bloomington, Indiana 47405, USA.
Feig
Andrew L
AL
D001426:Bacterial Proteins / Q000737:chemistry / Q000493:pharmacokinetics / Q000633:toxicity; D001427:Bacterial Toxins / Q000737:chemistry / Q000493:pharmacokinetics / Q000633:toxicity; D002784:Cholesterol / Q000172:deficiency; D016360:Clostridioides difficile / Q000378:metabolism* / Q000472:pathogenicity; D003428:Cross Infection / Q000453:epidemiology / Q000517:prevention & control; D003967:Diarrhea / Q000382:microbiology; D004761:Enterocolitis, Pseudomembranous / Q000453:epidemiology*; D004768:Enterotoxins / Q000737:chemistry / Q000493:pharmacokinetics / Q000633:toxicity; D006801:Humans; D008563:Membrane Lipids / Q000502:physiology; D009894:Opportunistic Infections / Q000382:microbiology*
D001426:Bacterial Proteins; D001427:Bacterial Toxins; D004768:Enterotoxins; D008563:Membrane Lipids; C041348:tcdA protein, Clostridium difficile; C031815:toxB protein, Clostridium difficile; D002784:Cholesterol