Increased hippocampal and cortical beta oscillations in mice deficient for the HNK-1 sulfotransferase.
The HNK-1 carbohydrate is detectable in perineuronal nets around inhibitory neurons in the hippocampus and neocortex. To address the functional contribution of HNK-1 to interneuron function in the adult brain, we recorded EEG and auditory-evoked potential in freely moving mice deficient for HNK-1 sulfotransferase (ST-/- mice) and in wild-type littermates. While ST-/- mice displayed normal theta oscillations, both cortical and hippocampal oscillations within the beta range were enhanced, and gamma oscillations showed an opposite trend. ST-/- mice had amplitudes of auditory-evoked potentials similar to control mice, but the latencies of their hippocampal responses were shorter. Morphological analysis revealed a decreased density of parvalbumin-positive interneurons in the hippocampal CA3 subfield of ST-/- mice, which may contribute to the observed changes in networks oscillations. These findings reveal alterations in ST-/- mice that differ from EEG abnormalities of mice deficient in the HNK-1 carrier molecule tenascin-R.
Gurevicius
Kestutis
K
Department of Neurobiology, A.I. Virtanen Institute, University of Kuopio, PO Box 1627, 70211 Kuopio, Finland. Kestutis.Gurevicius@uku.fi
Gureviciene
Irina
I
Sivukhina
Elena
E
Irintchev
Andrey
A
Schachner
Melitta
M
Tanila
Heikki
H
D000161:Acoustic Stimulation / Q000379:methods; D000818:Animals; D002452:Cell Count / Q000379:methods; D002540:Cerebral Cortex / Q000502:physiology*; D005072:Evoked Potentials, Auditory / Q000235:genetics; D006624:Hippocampus / Q000166:cytology / Q000502:physiology*; D007395:Interneurons / Q000378:metabolism; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D010320:Parvalbumins / Q000378:metabolism; D011930:Reaction Time; D015238:Sulfotransferases / Q000172:deficiency*; D013826:Theta Rhythm
D010320:Parvalbumins; C109318:HNK-1 sulfotransferase; D015238:Sulfotransferases