title: Intravaginal administration of an inactivated vaccine prevents lesions induced by caprine herpesvirus-1 in goats.
abstract: To evaluate the efficacy of mucosal vaccination with a beta-propiolactone inactivated caprine herpesvirus-1 (CpHV-1) vaccine, goats received vaginal administrations of two 7-day cycles at 2 weeks intervals. Seven days after the end of the second cycle, goats were challenged intravaginally with 4 ml of virulent BA.1 strain of CpHV-1. Vaccinated goats shed challenge virus for 8 days but, in comparison with control unvaccinated-challenged goats, were significantly protected from the classical clinical signs of genital lesions. Even without adjuvants, prolonged mucosal vaccination induced production of secretory IgA and provided significant clinical protection.
authors.affiliation: Department of Animal Health and Well-being, Faculty of Veterinary Medicine, University of Bari, Strada P.le per Casamassima km 3, 70010 Valenzano, Italy.
authors.forename: Michele
authors.initials: M
authors.lastname: Camero
authors.forename: Anna Lucia
authors.initials: AL
authors.lastname: Bellacicco
authors.forename: Elvira
authors.initials: E
authors.lastname: Tarsitano
authors.forename: Nicola
authors.initials: N
authors.lastname: Decaro
authors.forename: Vito
authors.initials: V
authors.lastname: Martella
authors.forename: Maria
authors.initials: M
authors.lastname: Tempesta
authors.forename: Canio
authors.initials: C
authors.lastname: Buonavoglia
mesh_terms: D000282:Administration, Intravaginal; D000818:Animals; D000914:Antibodies, Viral / Q000378:metabolism; D002460:Cell Line; D005260:Female; D015511:Goat Diseases / Q000276:immunology / Q000517:prevention & control* / Q000821:virology; D006041:Goats; D006566:Herpesviridae Infections / Q000276:immunology / Q000517:prevention & control / Q000662:veterinary*; D022283:Herpesvirus Vaccines / Q000008:administration & dosage / Q000276:immunology*; D018928:Immunity, Mucosal; D007071:Immunoglobulin A, Secretory / Q000378:metabolism; D015164:Vaccines, Inactivated / Q000008:administration & dosage / Q000276:immunology*; D018140:Varicellovirus / Q000276:immunology* / Q000472:pathogenicity
chemical_list: D000914:Antibodies, Viral; D022283:Herpesvirus Vaccines; D007071:Immunoglobulin A, Secretory; D015164:Vaccines, Inactivated