[TSH, FT4 and T3T evaluation in normal and preterm hospitalized newborns].
Thyroid hormones are essential for foetus and newborn development. Preterm newborns present low levels for thyroid hormones. These low levels are related with disorder in psychomotor and neurological development. In the literature, several studies concerning newborns treated with thyroid hormone have been realized in different conditions; however, there is no consensus about preterm newborn supplementation benefit.


OBJECTIVE
The aim of the study was to defined hormonal values used for normal and preterm newborns.


METHODS
We reported TSH, T3T and T4L levels for 195 normal or preterm newborns, eutrophic or small for gestational age (SGA).


RESULTS
A positive correlation was found between hormonal level and gestational age. This work allowed us to define a threshold for preterm newborn according to their gestational age.


CONCLUSIONS
Owing to lack of consensus, those values are useful for clinical and biological follow-up of thyroid function for newborns at risk (SGA and preterm before 32 weeks) during the first year of life. Finally, it would be interesting to study systematic supplementation of thyroid hormone for those infants in a prospective study.
Cartault Grandmottet
A
A
Unité d'endocrinologie, pathologie osseuse, gynécologie et génétique, hôpital des Enfants, CHU de Toulouse, TSA 70034, 31059 Toulouse, France. cartault.a@chu-toulouse.fr
Cristini
C
C
Tricoire
J
J
Rolland
M
M
Tauber
M-T
MT
Salles
J-P
JP
D005865:Gestational Age; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D007231:Infant, Newborn / Q000097:blood*; D007234:Infant, Premature / Q000502:physiology*; D007236:Infant, Small for Gestational Age / Q000502:physiology; D012016:Reference Values; D013972:Thyrotropin / Q000097:blood*; D013974:Thyroxine / Q000097:blood*; D014284:Triiodothyronine / Q000097:blood*
D014284:Triiodothyronine; D013972:Thyrotropin; D013974:Thyroxine