title: Mid-term results in otherwise treatment refractory primary or secondary liver confined tumours treated with selective internal radiation therapy (SIRT) using (90)Yttrium resin-microspheres.
abstract: The purpose was to determine the response and survival and to analyse the feasibility of single-session, whole-liver SIRT in patients with non-resectable, otherwise non-responding liver cancer. Thirty-nine patients qualified for SIRT. Eighteen patients suffered from colorectal-cancer metastases (CRC), breast-cancer metastases (MBC, 7), HCC (5) and other tumours (9). Response was assessed by tumour-markers and CT-imaging. At 2-4, 5-7 and 8-9 months follow-up in 3/17, 5/15 and 5/10 of CRC-patients CEA-levels were higher than before. In the MBC group 1-3 and 4-6 months after SIRT tumour-marker-levels were higher in 2/6 and 3/3 patients, respectively. In all HCC-patients AFP-levels dropped 1-3 months after SIRT. Using RECIST, in the CRC-group progressive liver disease (PD) was found in 4/17, 2/12, 2/10 and 2/5 patients at 2-4, 5-8, 9-10 and 12-14 months follow-up. Concerning MBC, after 3 months 7/7 patients presented with stable-disease (SD) or partial-response (PR). At 5-6 months, 1/5 patients showed PD. All HCC-patients showed SD/PR at 2-3 months with no PD at 5-8 months. In the mixed-group 5/6 patients presented with SD/PR at 3-4 months and with SD in 2/3 patients at 5-6 months. The median time-to-PD was 6.5, 8.5 and 8 months for the CRC-, MBC- and mixed-group, respectively. SIRT is a promising, liver-targeted approach for patients with otherwise treatment-refractory liver tumours.
authors.affiliation: Department of Clinical Radiology, University of Munich, Grosshadern Campus, Marchioninistrasse 15, 81377, Munich, Germany. tobias.jakobs@med.uni-muenchen.de
authors.forename: Tobias F
authors.initials: TF
authors.lastname: Jakobs
authors.forename: Ralf-T
authors.initials: RT
authors.lastname: Hoffmann
authors.forename: Gabriele
authors.initials: G
authors.lastname: Poepperl
authors.forename: Anna
authors.initials: A
authors.lastname: Schmitz
authors.forename: Jürgen
authors.initials: J
authors.lastname: Lutz
authors.forename: Walter
authors.initials: W
authors.lastname: Koch
authors.forename: Klaus
authors.initials: K
authors.lastname: Tatsch
authors.forename: Andreas
authors.initials: A
authors.lastname: Lubiensky
authors.forename: Maximilian F
authors.initials: MF
authors.lastname: Reiser
authors.forename: Thomas
authors.initials: T
authors.lastname: Helmberger
mesh_terms: D001918:Brachytherapy / Q000379:methods*; D018450:Disease Progression; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000532:radiotherapy* / Q000556:secondary; D008297:Male; D008863:Microspheres; D009367:Neoplasm Staging; D015996:Survival Rate; D014055:Tomography, Emission-Computed; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D015021:Yttrium Radioisotopes / Q000627:therapeutic use*
chemical_list: D015021:Yttrium Radioisotopes