Relationship between serum magnesium values, lipids and anthropometric risk factors.
Serum magnesium (SMg) has been reported to negatively correlate with an atherogenic lipid profile in individuals with diabetes mellitus (DM) and metabolic syndrome. This study examines whether the relationships between SMg levels and biochemical and anthropometric risk factors for these conditions are also present in the general adult population.


METHODS
Biochemical parameters and anthropometric variables were assessed in 1318 healthy adult subjects recruited from the Newfoundland population.


RESULTS
SMg positively correlated with age, and serum phosphate, calcium, albumin, total cholesterol, HDL-cholesterol, LDL-cholesterol and triglyceride levels. SMg negatively correlated with HOMA-beta and percent body fat measured by DEXA. On sub-grouping subjects according to sex, menopausal status or after excluding subjects with DM, only a significant correlation of SMg with albumin, calcium, phosphate, and total cholesterol was common to all. Stepwise linear regression analysis revealed albumin, phosphate, age, total cholesterol, glucose, and body mass index as independent predictors of SMg levels.


CONCLUSIONS
These results indicate that SMg levels positively correlate with total cholesterol and possibly all lipoproteins in a large adult study population which suggests that variation of SMg with serum lipid levels may be different in healthy individuals compared with those with DM. We speculate on a possible binding interaction.
Randell
Edward W
EW
Division of Laboratory Medicine, Faculty of Medicine, Memorial University of Newfoundland, St. John's, Nfld A1B 3V6, Canada; Division of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St. John's, Nfld A1B 3V6, Canada; Health Care Corporation of St. John's, St. John's, Nfld A1B 3V6, Canada. Electronic address: erandell@mun.ca.
Mathews
Maria
M
Division of Community Health, Faculty of Medicine, Memorial University of Newfoundland, St. John's, Nfld A1B 3V6, Canada.
Gadag
Veeresh
V
Division of Community Health, Faculty of Medicine, Memorial University of Newfoundland, St. John's, Nfld A1B 3V6, Canada.
Zhang
Hongwei
H
Division of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St. John's, Nfld A1B 3V6, Canada.
Sun
Guang
G
Division of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St. John's, Nfld A1B 3V6, Canada.
D000273:Adipose Tissue; D000328:Adult; D000368:Aged; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000453:epidemiology; D005260:Female; D006801:Humans; D008074:Lipoproteins / Q000097:blood*; D008274:Magnesium / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009523:Newfoundland and Labrador / Q000453:epidemiology; D009765:Obesity / Q000097:blood* / Q000453:epidemiology; D012307:Risk Factors
D008074:Lipoproteins; D008274:Magnesium