title: Bone geometric response to chronic disuse following stroke: a pQCT study.
abstract: OBJECTIVE
  The objectives of this study were to 1) assess volumetric bone geometry and density at the distal radius of individuals with chronic stroke and 2) assess whether bone strength is associated with measures of muscle strength and impairment.
  
  
  METHODS
  Cross-sectional study of bone and muscle parameters in 15 community-dwelling people living with the residual effects of a stroke (between 1 and 9 years post-incident stroke).
  
  
  RESULTS
  The 4% site of the distal radius had significantly lower bone mineral content and density on the paretic side (p<0.006). There was a significant difference in pQCT measures of bone cortical density (p<0.03), area (p<0.05) and bone strength [Stress-Strain Index; SSI] (p<0.01) (lower on the paretic side) at the 30%. We found significant correlations between composite muscle strength score of the upper extremities and pQCT-generated bone strength.
  
  
  CONCLUSIONS
  This cross-sectional study highlights lower bone strength on the paretic limb and an adaptive response to disuse.
authors.affiliation: Department of Family Practice, University of British Columbia, Vancouver, British Columbia, Canada V6T 1V6. mashe@telus.net
authors.forename: M C
authors.initials: MC
authors.lastname: Ashe
authors.forename: P
authors.initials: P
authors.lastname: Fehling
authors.forename: J J
authors.initials: JJ
authors.lastname: Eng
authors.forename: K M
authors.initials: KM
authors.lastname: Khan
authors.forename: H A
authors.initials: HA
authors.lastname: McKay
mesh_terms: D001696:Biomechanical Phenomena; D015519:Bone Density; D001842:Bone and Bones / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000503:physiopathology*; D020966:Muscular Disorders, Atrophic / Q000209:etiology*; D020521:Stroke / Q000150:complications* / Q000503:physiopathology*; D014057:Tomography, X-Ray Computed