title: Telomere shortening in human HL60 cells by treatment with deoxyguanosine analogs.
abstract: Telomerase is a cellular endogenous reverse transcriptase thought to play an important role in the maintenance of telomere length. We investigated the effects of 3'-azido-2',3'-dideoxyguanosine (AZddG) and carbocyclic oxetanocin G (C.OXT-G), of which the triphosphate derivatives AZddGTP and C.OXT-GTP show potent telomerase inhibition, on telomere length of human HL60 cells in culture. Although AZddG caused more significant telomere shortening than C.OXT-G, only a slight decrease of cell growth rate was observed.
authors.affiliation: Department of Biological Sciences, Teikyo University of Science and Technology, Uenohara, Yamanashi 409-0193, Japan.
authors.forename: Toyofumi
authors.initials: T
authors.lastname: Yamaguchi
authors.forename: Hazuki
authors.initials: H
authors.lastname: Takahashi
authors.forename: Yoko
authors.initials: Y
authors.lastname: Harada
authors.forename: Masato
authors.initials: M
authors.lastname: Yoshikawa
authors.forename: Saori
authors.initials: S
authors.lastname: Iyono
authors.forename: Motoko
authors.initials: M
authors.lastname: Inomata
authors.forename: Tokumi
authors.initials: T
authors.lastname: Maruyama
authors.forename: Mineo
authors.initials: M
authors.lastname: Saneyoshi
mesh_terms: D002455:Cell Division / Q000187:drug effects; D003849:Deoxyguanosine / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology*; D018922:HL-60 Cells; D006801:Humans; D016615:Telomere / Q000378:metabolism*
chemical_list: D003849:Deoxyguanosine