title: Genetic distance of SARS coronavirus from the recent natural case.
abstract: Phylogenetic analysis of SARS coronavirus isolates based on the spike gene and protein sequence using Neighbor-Joining, maximum likelihood and Bayesian inference methods indicated that a recent human SARS-CoV isolate was closer to some human SARS-CoV isolates from earlier epidemic phase than to the SARS-CoV-like viruses isolated from wild animals during previous epidemic phase. A reasonable judgment based on phylogenetic relationship and sequence variations it is likely that the recent human SARS-CoV isolate is closer to an unknown SARS-CoV predecessor.
authors.affiliation: Zhejiang Provincial Center for Disease Prevention and Control, 17 Laozhedazhi Road, Hangzhou 310009, China. wzg188@126.com
authors.forename: Zhi-Gang
authors.initials: ZG
authors.lastname: Wang
authors.forename: Shu-Ping
authors.initials: SP
authors.lastname: Xu
authors.forename: Yan-Jun
authors.initials: YJ
authors.lastname: Zhang
authors.forename: Qi-Yu
authors.initials: QY
authors.lastname: Bao
mesh_terms: D000595:Amino Acid Sequence; D019943:Amino Acid Substitution; D000818:Animals; D003333:Coronaviridae Infections / Q000821:virology*; D014644:Genetic Variation; D006801:Humans; D008562:Membrane Glycoproteins / Q000737:chemistry / Q000235:genetics; D010802:Phylogeny; D045473:Severe acute respiratory syndrome-related coronavirus / Q000145:classification / Q000235:genetics*; D017421:Sequence Analysis; D064370:Spike Glycoprotein, Coronavirus; D014759:Viral Envelope Proteins / Q000737:chemistry / Q000235:genetics
chemical_list: D008562:Membrane Glycoproteins; D064370:Spike Glycoprotein, Coronavirus; D014759:Viral Envelope Proteins; C578557:spike glycoprotein, SARS-CoV