title: Comprehensive association analysis of the NOS2A gene with Parkinson disease.
abstract: Inducible nitric oxide synthase (NOS2A) may be involved in the oxidative stress pathology of Parkinson disease (PD). Two previous studies reported an association of a single nucleotide polymorphism (rs1060826) with PD. A replication study of 340 German patients and 680 controls showed no significant association between 12 genotyped polymorphisms and PD. NOS2A is therefore not a major susceptibility locus in our relatively young sample population.
authors.affiliation: Hertie-Institute for Clinical Brain Research, Section for Neurodegenerative Diseases, University of Tübingen, Hoppe-Seyler Str. 3, 72076 Tübingen, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Schulte
authors.forename: M
authors.initials: M
authors.lastname: Sharma
authors.forename: J C
authors.initials: JC
authors.lastname: Mueller
authors.forename: P
authors.initials: P
authors.lastname: Lichtner
authors.forename: J
authors.initials: J
authors.lastname: Prestel
authors.forename: D
authors.initials: D
authors.lastname: Berg
authors.forename: T
authors.initials: T
authors.lastname: Gasser
mesh_terms: D000483:Alleles; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006801:Humans; D015810:Linkage Disequilibrium / Q000235:genetics; D018895:Microsatellite Repeats / Q000235:genetics; D008875:Middle Aged; D052247:Nitric Oxide Synthase Type II / Q000235:genetics*; D010300:Parkinson Disease / Q000201:enzymology* / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics
chemical_list: C496319:NOS2 protein, human; D052247:Nitric Oxide Synthase Type II