title: Physical activity and motor decline in older persons.
abstract: We tested the hypothesis that physical activity modifies the course of age-related motor decline. More than 850 older participants of the Rush Memory and Aging Project underwent baseline assessment of physical activity and annual motor testing for up to 8 years. Nine strength measures and nine motor performance measures were summarized into composite measures of motor function. In generalized estimating equation models, global motor function declined during follow-up (estimate, -0.072; SE, 0.008; P < 0.001). Each additional hour of physical activity at baseline was associated with about a 5% decrease in the rate of global motor function decline (estimate, 0.004; SE, 0.001; P = 0.007). Secondary analyses suggested that the association of physical activity with motor decline was mostly due to the effect of physical activity on the rate of motor performance decline. Thus, higher levels of physical activity are associated with a slower rate of motor decline in older persons.
authors.affiliation: Rush Alzheimer's Disease Center, Rush University Medical Center, Armour Academic Facility, Suite 1038, 600 South Paulina Street, Chicago, Illinois 60612, USA. Aron_S_Buchman@rush.edu
authors.forename: A S
authors.initials: AS
authors.lastname: Buchman
authors.forename: P A
authors.initials: PA
authors.lastname: Boyle
authors.forename: R S
authors.initials: RS
authors.lastname: Wilson
authors.forename: Julia L
authors.initials: JL
authors.lastname: Bienias
authors.forename: D A
authors.initials: DA
authors.lastname: Bennett
mesh_terms: D000203:Activities of Daily Living / Q000523:psychology; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D015331:Cohort Studies; D005081:Exercise Therapy / Q000379:methods*; D017079:Exercise Tolerance / Q000502:physiology; D005260:Female; D006801:Humans; D008136:Longevity / Q000502:physiology; D008137:Longitudinal Studies; D008297:Male; D051346:Mobility Limitation; D009043:Motor Activity / Q000502:physiology; D053580:Muscle Strength / Q000502:physiology; D018908:Muscle Weakness / Q000175:diagnosis / Q000503:physiopathology / Q000517:prevention & control*; D018482:Muscle, Skeletal / Q000503:physiopathology*; D010809:Physical Fitness