title: FDG-PET in the initial staging of squamous cell oesophageal carcinoma.
abstract: Squamous cell oesophageal carcinoma is the most common carcinoma of the oesophagus worldwide. The tumour stage as most important prognostic factor determines the clinical management.
  
  
  OBJECTIVE
  of this study was to evaluate the value of FDG-PET 1. in imaging the primary tumour and 2. in N- and M-staging of squamous cell oesophageal carcinoma.
  
  
  METHODS
  In 20 patients with histological proven squamous cell carcinoma of the upper and middle oesophagus, FDG-PET was performed in standard technique prior to therapy. FDG uptake in the primary was determined by calculation of the SUVmax. NM-staging due to PET findings was performed as designated by the AJCC/UICC group classification and was compared with pathological and clinically based staging. Sensitivities, specificities and accuracies were calculated.
  
  
  RESULTS
  In 19 of 20 patients, primary squamous cell oesopohageal carcinoma was detected by FDG-PET findings with a maximum SUV of 12.5 (mean) +/- 5.1 (median 11.5; range 4.8-23.8). One carcinoma in situ was missed. The sensitivity of FDG-PET in imaging the primary tumour was 96%. The sensitivities, specificities and accuracies were 20%, 100%, 58% for N-staging, and 60%, 86% and 93% for M-staging. PET findings caused changes of therapy in 5% (1 patient).
  
  
  CONCLUSIONS
  FDG-PET was excellent in imaging the primary of squamous cell oesophageal carcinoma in stage T1-T4 and was efficient in M-staging. The low sensitivity in N-staging is of inferior clinical importance. The efficacy of FDG-PET seems to be not significantly be influenced by the histological subtype of oesophageal carcinoma.
authors.affiliation: Nuclear Medicine, University Hospital Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany. inga.buchmann@med.uni-heidelberg.de
authors.forename: I
authors.initials: I
authors.lastname: Buchmann
authors.forename: T
authors.initials: T
authors.lastname: Hansen
authors.forename: C
authors.initials: C
authors.lastname: Brochhausen
authors.forename: W
authors.initials: W
authors.lastname: Kneist
authors.forename: K
authors.initials: K
authors.lastname: Oberholzer
authors.forename: T
authors.initials: T
authors.lastname: Junginger
authors.forename: M
authors.initials: M
authors.lastname: Schreckenberger
authors.forename: P
authors.initials: P
authors.lastname: Bartenstein
mesh_terms: D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000000981:diagnostic imaging*; D004938:Esophageal Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D049268:Positron-Emission Tomography; D011859:Radiography; D011868:Radioisotopes
chemical_list: D011868:Radioisotopes; D019788:Fluorodeoxyglucose F18