Ir-catalyzed functionalization of 2-substituted indoles at the 7-position: nitrogen-directed aromatic borylation.
Ir-catalyzed borylation of 2-substituted indoles selectively yields 7-borylated products in good yields. N-Protection, required for previous functionalizations of 2-substituted indoles, is unnecessary.
Paul
Sulagna
S
Department of Chemistry, Michigan State University, East Lansing, Michigan 48824-1322, USA.
Chotana
Ghayoor A
GA
Holmes
Daniel
D
Reichle
Rebecca C
RC
Maleczka
Robert E
RE
Smith
Milton R
MR
D001896:Boron Compounds / Q000138:chemical synthesis*; D002384:Catalysis; D003903:Deuterium / Q000737:chemistry; D006571:Heterocyclic Compounds / Q000138:chemical synthesis*; D006841:Hydrocarbons, Aromatic / Q000138:chemical synthesis*; D007211:Indoles / Q000737:chemistry*; D015394:Molecular Structure; D009584:Nitrogen / Q000737:chemistry*; D009942:Organometallic Compounds / Q000138:chemical synthesis*
D001896:Boron Compounds; D006571:Heterocyclic Compounds; D006841:Hydrocarbons, Aromatic; D007211:Indoles; D009942:Organometallic Compounds; D003903:Deuterium; D009584:Nitrogen