title: Drug release from functionalized oligodeoxynucleotide by photo-induced electron transfer.
abstract: We synthesized a photoreactive hairpin-type oligodeoxynucleotide (P-ODN) possessing an o-nitrobenzyl chromophore and a triplet quencher of 1-aminonaphthalene. Photoirradiation of the hybrid of H-ODN with its complementary DNA led to release of drug in an efficient amount, while the photo-induced drug release was remarkably suppressed in the absence of complementary DNA.
authors.affiliation: Department of Energy and Hydrocarbon Chemistry, Graduate School of Engineering, Kyoto University, Katsura Campus, Kyoto 615-8510, Japan.
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Tachi
authors.forename: Arimichi
authors.initials: A
authors.lastname: Okazaki
authors.forename: Kazuhito
authors.initials: K
authors.lastname: Tanabe
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Hatta
authors.forename: Sei-ichi
authors.initials: S
authors.lastname: Nishimoto
mesh_terms: D001483:Base Sequence; D019817:Benzoic Acid; D018076:DNA, Complementary / Q000528:radiation effects; D016503:Drug Delivery Systems / Q000379:methods*; D004583:Electrons; D008027:Light; D008969:Molecular Sequence Data; D009690:Nucleic Acid Conformation / Q000528:radiation effects; D009838:Oligodeoxyribonucleotides / Q000737:chemistry* / Q000235:genetics / Q000528:radiation effects*
chemical_list: D018076:DNA, Complementary; D009838:Oligodeoxyribonucleotides; D019817:Benzoic Acid