Familial history of type 2 diabetes in patients from Southern Brazil and its influence on the clinical characteristics of this disease.
OBJECTIVE
To investigate the presence of maternal and paternal history of type 2 diabetes mellitus (DM) in relatives of 644 type 2 diabetic patients from Southern Brazil, and also to evaluate its influence on the clinical characteristics of this disease.


METHODS
Familial history of type 2 DM was investigated by a questionnaire. The maternal and paternal history was investigated over two generations. Complete data sets on familial history were obtained from 396 patients.


RESULTS
In general, 76.6% of the patients reported at least one first-degree affected relative. Besides, 31.6% of the patients reported a maternal history of type 2 DM and 12.6% reported a paternal history. Patients with maternal and/or paternal history presented a lower age at type 2 DM diagnosis when compared to patients without familial history. In addition, patients with only paternal history presented a higher frequency of hypertension than patients with no familial history.


CONCLUSIONS
This study suggests that there is a significant maternal effect in the transmission of type 2 DM in Southern Brazil, and that most of the clinical characteristics of this disease do not differ between patients with or without familial history of type 2 DM.
Crispim
Daisy
D
Departamento de Genetica, Universidade Federal do Rio Grande do Sul.
Canani
Luís H
LH
Gross
Jorge L
JL
Tschiedel
Balduíno
B
Souto
Kátia E P
KE
Roisenberg
Israel
I
D000328:Adult; D017668:Age of Onset; D000419:Albuminuria / Q000652:urine; D044383:Black People / Q000235:genetics; D001786:Blood Glucose / Q000032:analysis; D001938:Brazil / Q000208:ethnology; D003924:Diabetes Mellitus, Type 2 / Q000208:ethnology / Q000235:genetics*; D004812:Epidemiologic Methods; D005220:Fathers; D005260:Female; D006801:Humans; D008297:Male; D008487:Medical History Taking; D008875:Middle Aged; D009035:Mothers; D010375:Pedigree; D011247:Pregnancy; D044465:White People / Q000235:genetics
D001786:Blood Glucose