title: Anti-SARS-CoV activity of nucleoside analogs having 6-chloropurine as a nucleobase.
abstract: Nucleoside analogs that have 6-chloropurine as a nucleobase were synthesized and evaluated to develop novel anti-SARS-CoV agents. Two compounds among them showed promising activity that was comparable to mizoribine and ribavirin. Moreover, one of the compounds showed a structurally unique property.
authors.affiliation: Faculty of Pharmaceutical Sciences at Kagawa Campus, Tokushima Bunri University, 1314-1 Shido, Sanuki, Kagawa 769-2193, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Ikejiri
authors.forename: Masayuki
authors.initials: M
authors.lastname: Saijo
authors.forename: Shigeru
authors.initials: S
authors.lastname: Morikawa
authors.forename: Shuetsu
authors.initials: S
authors.lastname: Fukushi
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Mizutani
authors.forename: Ichiro
authors.initials: I
authors.lastname: Kurane
authors.forename: Tokumi
authors.initials: T
authors.lastname: Maruyama
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D011684:Purine Nucleosides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D011687:Purines / Q000737:chemistry*; D045473:Severe acute respiratory syndrome-related coronavirus / Q000187:drug effects* / Q000254:growth & development; D010948:Viral Plaque Assay
chemical_list: D000998:Antiviral Agents; D011684:Purine Nucleosides; D011687:Purines; C079308:6-chloropurine