Protein nutrition as therapy for a genetic disorder of bone?
Bone formation is controlled by a network of transcription factors and signaling molecules. In this issue, , studying the role of the transcription factor ATF4 in a new mouse model of neurofibromatosis type I skeletal defects, demonstrate striking effects of changing dietary protein on bone formation abnormalities.
Martin
T John
TJ
St. Vincent's Institute of Medical Research and Department of Medicine, University of Melbourne, 41 Victoria Parade, Fitzroy, Victoria 3065, Australia.
D051701:Activating Transcription Factor 4 / Q000378:metabolism*; D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D001693:Biological Transport, Active / Q000187:drug effects / Q000235:genetics; D001848:Bone Diseases, Developmental / Q000151:congenital / Q000178:diet therapy* / Q000378:metabolism* / Q000473:pathology; D001862:Bone Resorption / Q000178:diet therapy / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D002454:Cell Differentiation / Q000187:drug effects / Q000235:genetics; D038921:Coffin-Lowry Syndrome / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D003094:Collagen / Q000096:biosynthesis; D017868:Cyclic AMP-Dependent Protein Kinases / Q000235:genetics / Q000378:metabolism; D004044:Dietary Proteins / Q000627:therapeutic use*; D051379:Mice; D018345:Mice, Knockout; D025542:Neurofibromin 1 / Q000172:deficiency / Q000378:metabolism*; D010006:Osteoblasts / Q000378:metabolism* / Q000473:pathology; D010010:Osteoclasts / Q000378:metabolism / Q000473:pathology; D010012:Osteogenesis / Q000235:genetics; D053245:RANK Ligand / Q000096:biosynthesis / Q000235:genetics; D038744:Ribosomal Protein S6 Kinases, 90-kDa / Q000172:deficiency / Q000378:metabolism
D000596:Amino Acids; C081452:Atf4 protein, mouse; D004044:Dietary Proteins; D025542:Neurofibromin 1; D053245:RANK Ligand; C505689:Tnfsf11 protein, mouse; D051701:Activating Transcription Factor 4; D003094:Collagen; D038744:Ribosomal Protein S6 Kinases, 90-kDa; C069330:ribosomal protein S6 kinase, 90kDa, polypeptide 3; D017868:Cyclic AMP-Dependent Protein Kinases