title: Effect of benzylic oxygen on the cytotoxic activity for colon 26 cell line of phenolic lignans.
abstract: The cytotoxic activity for colon 26 cell line of matairesinol, oxidized matairesinol, 9,9'-epoxylignan and oxidized 9,9'-epoxylignan were examined. (-)-Matairesinol (Mat 1) showed greatest cytotoxic activity (LC(50)=9 microg/ml) of the lactone-type lignans. 7,7'-Oxomatairesinol having same steric configuration as that of (-)-matairesinol showed greater activity (LC(50)=25 microg/ml) than hydroxy or mono-oxomatairesinol. The activities of 9,9'-epoxylignan and 7,7'-oxo-9,9'-epoxylignan having same steric configurations as (-)-matairesinol were weaker than that of corresponding matairesinols. Different activity levels were observed between enantiomers.
authors.affiliation: Faculty of Agriculture, Ehime University. syamauch@agr.ehime-u.ac.jp
authors.forename: Satoshi
authors.initials: S
authors.lastname: Yamauchi
authors.forename: Takuya
authors.initials: T
authors.lastname: Sugahara
authors.forename: Yuki
authors.initials: Y
authors.lastname: Nakashima
authors.forename: Koki
authors.initials: K
authors.lastname: Abe
authors.forename: Yoshimasa
authors.initials: Y
authors.lastname: Hayashi
authors.forename: Koichi
authors.initials: K
authors.lastname: Akiyama
authors.forename: Taro
authors.initials: T
authors.lastname: Kishida
authors.forename: Masafumi
authors.initials: M
authors.lastname: Maruyama
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D017705:Lignans / Q000737:chemistry / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008807:Mice, Inbred BALB C; D015394:Molecular Structure; D010100:Oxygen / Q000378:metabolism*; D010636:Phenols / Q000494:pharmacology*; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: D017705:Lignans; D010636:Phenols; D010100:Oxygen