title: [Expressions of TGF-betaR I, Smad2, Smad3 and Smad7 in keloids].
abstract: OBJECTIVE
  To investigate the expression of TGF-betaR I, Smad2, Smad3 and Smad7 in keloids, normal scars and normal skins. Discuss the significance of these proteins in the course of keloid.
  
  
  METHODS
  Immunohistochemistry method was used to detect the expression intensity and distribution of these proteins in above 3 kinds of different tissues in 44 cases. Statistics was used to analyze the data.
  
  
  RESULTS
  The expression of TGF-betaR I were much stronger in keloid than in the other two tissues. The expression of Smad7 were lower in keloids. The increase expression of Smad2,3 were not obvious, but they were found to accumulate in the nucleus.
  
  
  CONCLUSIONS
  The results indicate that over-expression of TGF-betaR I, low-expression of Smad7 and accumulation of Smad2,3 may be one of the etiological factors of keloids. This research may provide a new idea to prevent and treat keloids or other fibrosis diseases in the future.
authors.affiliation: Department of Plastic Surgery, Zhejiang Provincial People's Hospital, Hangzhou 310014, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Sun
authors.forename: Jian-xing
authors.initials: JX
authors.lastname: Song
authors.forename: Zi-min
authors.initials: ZM
authors.lastname: Wang
authors.forename: Jiang-ping
authors.initials: JP
authors.lastname: Chen
authors.forename: Ying
authors.initials: Y
authors.lastname: Chen
authors.forename: Xiao-jie
authors.initials: XJ
authors.lastname: Tan
authors.forename: Jin
authors.initials: J
authors.lastname: Bai
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D007627:Keloid / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D000077293:Receptor, Transforming Growth Factor-beta Type I; D018125:Receptors, Transforming Growth Factor beta / Q000378:metabolism*; D051899:Smad2 Protein / Q000378:metabolism*; D051900:Smad3 Protein / Q000378:metabolism*; D051906:Smad7 Protein / Q000378:metabolism*; D055815:Young Adult
chemical_list: D018125:Receptors, Transforming Growth Factor beta; D051899:Smad2 Protein; D051900:Smad3 Protein; D051906:Smad7 Protein; D017346:Protein Serine-Threonine Kinases; D000077293:Receptor, Transforming Growth Factor-beta Type I