A case of anaplastic ductal carcinoma of the pancreas with production of granulocyte-colony stimulating factor.
We report a case of anaplastic ductal carcinoma of the pancreas with production of granulocytecolony stimulating factor in a 46-year-old man. He underwent distal pancreatectomy, total gastrectomy with Roux-en-Y reconstruction and splenectomy. He recovered uneventfully postoperatively and was discharged from hospital on the 22nd postoperative day. Histological examination showed anaplastic ductal carcinoma (giant cell type) of the pancreas. However, three months after the operation, multiple liver metastases were demonstrated by CT scan and the peripheral leukocyte count rose to 81,800/microL. Serum granulocyte-colony stimulating factor concentration was 155pg/mL (normal 5.78-27.5 pg/mL). Therefore, we diagnosed granulocyte-colony stimulating factor-producing pancreatic cancer. Anaplastic ductal carcinoma of the pancreas with production of granulocyte-colony stimulating factor is very rare. Tumors with production of granulocyte-colony stimulating factor are highly malignant, and this patient died of hepatic failure four months after the operation.
Gotohda
Naoto
N
Department of Hepatobiliary-Pancreatic Surgery, National Cancer Center Hospital East, Chiba, Japan. ngotohda@east.ncc.go.jp
Nakagohri
Toshio
T
Saito
Norio
N
Ono
Masato
M
Sugito
Masanori
M
Ito
Masaaki
M
Inoue
Kazuto
K
Oda
Tatsuya
T
Takahashi
Shinichiro
S
Kinoshita
Taira
T
D044584:Carcinoma, Ductal / Q000378:metabolism* / Q000556:secondary / Q000601:surgery*; D017809:Fatal Outcome; D005743:Gastrectomy; D016179:Granulocyte Colony-Stimulating Factor / Q000378:metabolism*; D006801:Humans; D007958:Leukocyte Count; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary; D008297:Male; D008875:Middle Aged; D010180:Pancreatectomy; D010190:Pancreatic Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000601:surgery*; D011859:Radiography; D013156:Splenectomy; D013274:Stomach Neoplasms / Q000556:secondary / Q000601:surgery; D015898:Tomography Scanners, X-Ray Computed
D016179:Granulocyte Colony-Stimulating Factor