title: Investigation of retrospective respiratory gating techniques for acquisition of thin-slice 4D-Multidetector-computed Tomorgraphy (MDCT) of the lung: Feasibility study in a large animal model.
abstract: Respiratory gated 3D-MDCT acquisition of the whole chest over time (4D-MDCT) allow retrospective reconstruction of raw data at any point of the respiratory cycle might be beneficial in severely ill or sedated patients. Aim of this feasibility study was to investigate 2 prototype devices as input for retrospective respiratory gating in order to calculate lung volumes (LVs) and mean lung densities (MLDs) over time. Sixteen-row MDCT data were acquired in 5 ventilated pigs using a laser sensor and charge-coupled devine (CCD) camera and retrospectively reconstructed at every 10% of the respiratory cycle. Semiautomatic segmentation of the 3D data sets was performed, and LV and MLD were calculated. Data acquisition was successful in all cases. The mean difference of LV between maximum inspiration and expiration was 246 and 240 mL (laser and CCD, respectively). The mean difference of MLD between inspiration and expiration was 70 (laser) and 67 (CCD) HU. The lowest MLD was found at the beginning of the respiratory cycle (0%) for laser, and at 90% for CCD. Both gating devices allowed for reliable 4D-MDCT image acquisition. No differences were found for calculated LV and MLD, whereas the respiratory cycle was more precisely detected using the laser based gating device.
authors.affiliation: Department of Radiology (E010), German Cancer Research Center (DKFZ), Heidelberg, Germany. ley@gmx.net
authors.forename: Sebastian
authors.initials: S
authors.lastname: Ley
authors.forename: Julia
authors.initials: J
authors.lastname: Ley-Zaporozhan
authors.forename: Roland
authors.initials: R
authors.lastname: Unterhinninghofen
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Saito
authors.forename: Michael
authors.initials: M
authors.lastname: Fabel-Schulte
authors.forename: Oliver
authors.initials: O
authors.lastname: Weinheimer
authors.forename: Jens-Peter
authors.initials: JP
authors.lastname: Schenk
authors.forename: Gabor
authors.initials: G
authors.lastname: Szabo
authors.forename: Hans-Ulrich
authors.initials: HU
authors.lastname: Kauczor
mesh_terms: D000818:Animals; D005240:Feasibility Studies; D007834:Lasers; D008168:Lung / Q000000981:diagnostic imaging* / Q000502:physiology; D023421:Models, Animal; D009068:Movement; D010781:Photography / Q000295:instrumentation; D015203:Reproducibility of Results; D015656:Respiratory Mechanics; D013552:Swine; D014057:Tomography, X-Ray Computed / Q000295:instrumentation / Q000379:methods*