title: Lactobacillus acidophilus modulates intestinal pain and induces opioid and cannabinoid receptors.
abstract: Abdominal pain is common in the general population and, in patients with irritable bowel syndrome, is attributed to visceral hypersensitivity. We found that oral administration of specific Lactobacillus strains induced the expression of mu-opioid and cannabinoid receptors in intestinal epithelial cells, and mediated analgesic functions in the gut-similar to the effects of morphine. These results suggest that the microbiology of the intestinal tract influences our visceral perception, and suggest new approaches for the treatment of abdominal pain and irritable bowel syndrome.
authors.affiliation: Institut National de la Santé et de la Recherche Médicale (INSERM) U795, Hôpital Swynghedauw, Rue A Verhaeghe, 59037 Lille Cedex, France.
authors.forename: Christel
authors.initials: C
authors.lastname: Rousseaux
authors.forename: Xavier
authors.initials: X
authors.lastname: Thuru
authors.forename: Agathe
authors.initials: A
authors.lastname: Gelot
authors.forename: Nicolas
authors.initials: N
authors.lastname: Barnich
authors.forename: Christel
authors.initials: C
authors.lastname: Neut
authors.forename: Laurent
authors.initials: L
authors.lastname: Dubuquoy
authors.forename: Caroline
authors.initials: C
authors.lastname: Dubuquoy
authors.forename: Emilie
authors.initials: E
authors.lastname: Merour
authors.forename: Karen
authors.initials: K
authors.lastname: Geboes
authors.forename: Mathias
authors.initials: M
authors.lastname: Chamaillard
authors.forename: Arthur
authors.initials: A
authors.lastname: Ouwehand
authors.forename: Greg
authors.initials: G
authors.lastname: Leyer
authors.forename: Didier
authors.initials: D
authors.lastname: Carcano
authors.forename: Jean-Frédéric
authors.initials: JF
authors.lastname: Colombel
authors.forename: Denis
authors.initials: D
authors.lastname: Ardid
authors.forename: Pierre
authors.initials: P
authors.lastname: Desreumaux
mesh_terms: D015746:Abdominal Pain / Q000503:physiopathology* / Q000517:prevention & control; D000284:Administration, Oral; D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000494:pharmacology; D000818:Animals; D063387:Cannabinoid Receptor Antagonists; D003106:Colon / Q000187:drug effects / Q000382:microbiology / Q000503:physiopathology; D004305:Dose-Response Relationship, Drug; D019073:HT29 Cells; D006801:Humans; D007211:Indoles / Q000008:administration & dosage / Q000494:pharmacology; D007422:Intestines / Q000187:drug effects / Q000382:microbiology / Q000503:physiopathology*; D007779:Lactobacillus acidophilus / Q000502:physiology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009020:Morphine / Q000008:administration & dosage / Q000494:pharmacology; D009270:Naloxone / Q000008:administration & dosage / Q000494:pharmacology; D009292:Narcotic Antagonists / Q000008:administration & dosage / Q000494:pharmacology; D019936:Probiotics / Q000008:administration & dosage / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D043885:Receptor, Cannabinoid, CB2 / Q000037:antagonists & inhibitors / Q000096:biosynthesis / Q000502:physiology; D043882:Receptors, Cannabinoid / Q000096:biosynthesis / Q000502:physiology*; D011957:Receptors, Opioid / Q000096:biosynthesis / Q000502:physiology*; D017450:Receptors, Opioid, mu / Q000037:antagonists & inhibitors / Q000096:biosynthesis / Q000502:physiology; D012007:Rectum / Q000187:drug effects / Q000382:microbiology / Q000503:physiopathology
chemical_list: D000701:Analgesics, Opioid; D063387:Cannabinoid Receptor Antagonists; D007211:Indoles; D009292:Narcotic Antagonists; D043885:Receptor, Cannabinoid, CB2; D043882:Receptors, Cannabinoid; D011957:Receptors, Opioid; D017450:Receptors, Opioid, mu; D009270:Naloxone; D009020:Morphine; C094023:iodopravadoline