title: Constitutive activation of NF-kappa B is not sufficient to disturb normal steady-state hematopoiesis.
abstract: Since nuclear factor-kappaB (NF-kappaB) is frequently activated in acute myeloid leukemia, we questioned whether active NF-kappaB can affect the cellular properties of cord blood CD34+ cells. The results demonstrated that NF-kappaB activation did not influence growth or differentiation properties of these cells. Furthermore, NF-kappaB activation was not sufficient to induce changes in stem- and progenitor cell numbers.
authors.forename: Hein
authors.initials: H
authors.lastname: Schepers
authors.forename: Bart J L
authors.initials: BJ
authors.lastname: Eggen
authors.forename: Jan Jacob
authors.initials: JJ
authors.lastname: Schuringa
authors.forename: Edo
authors.initials: E
authors.lastname: Vellenga
mesh_terms: D002460:Cell Line; D006410:Hematopoiesis / Q000502:physiology*; D006801:Humans; D016328:NF-kappa B / Q000378:metabolism*
chemical_list: D016328:NF-kappa B