Insights into the general and efficient cross McMurry reactions between ketones.
The selective cross McMurry couplings of diaryl or aryl ketones with various substituted ketones were achieved in 53-94% isolated yields. It is believed that the strong affinity of the substituents to the low-valent titanium surface plays an important role in regards to moderating selectivity. Through the introduction of such substituents followed by their removal post McMurry coupling, structurally similar ketones can be effectively cross-coupled.
Duan
Xin-Fang
XF
Department of Chemistry, Beijing Normal University, Beijing, 100875, China. xinfangduan@vip.163.com
Zeng
Jing
J
Lü
Jia-Wei
JW
Zhang
Zhan-Bin
ZB
D001555:Benzene Derivatives / Q000138:chemical synthesis* / Q000737:chemistry; D007659:Ketones / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism; D014025:Titanium / Q000737:chemistry
D001555:Benzene Derivatives; D007659:Ketones; D014025:Titanium