title: Preferential aggregation of obsessive-compulsive spectrum disorders in schizophrenia patients with obsessive-compulsive disorder.
abstract: OBJECTIVE
  To validate a complex association between schizophrenia and obsessive-compulsive disorder (OCD).
  
  
  METHODS
  We used the Structured Clinical Interview for DSM-IV Axis I disorders to compare the rate of OCD spectrum and additional Axis I disorders in 100 patients who met criteria for both schizophrenia and OCD, non-OCD schizophrenia (n = 100), and OCD (n = 35).
  
  
  RESULTS
  There was a robust between-group difference in the number of patients with one or more OCD spectrum disorders (schizo-obsessive n = 30, compared with schizophrenia n = 8; P = 0.001), that is, higher rates of body dysmorphic (8% compared with 0%) and tic (16% compared with 4%) disorders. No difference was revealed in affective, anxiety, and substance use disorders. We found comparable rates of OCD spectrum disorders in the schizo-obsessive and OCD groups (30% and 42.8%, respectively; P = 0.32).
  
  
  CONCLUSIONS
  Preferential aggregation of OCD spectrum disorders in the schizo-obsessive group supports this unique clinical association. Whether a schizo-obsessive interface represents comorbidity or a specific subtype of schizophrenia warrants further investigation.
authors.affiliation: Research Unit, Tirat Carmel Mental Health Center, Israel. poyurovs@tx.technion.ac.il
authors.forename: Michael
authors.initials: M
authors.lastname: Poyurovsky
authors.forename: Camil
authors.initials: C
authors.lastname: Fuchs
authors.forename: Sarit
authors.initials: S
authors.lastname: Faragian
authors.forename: Victoria
authors.initials: V
authors.lastname: Kriss
authors.forename: Gregory
authors.initials: G
authors.lastname: Weisman
authors.forename: Artashez
authors.initials: A
authors.lastname: Pashinian
authors.forename: Ronit
authors.initials: R
authors.lastname: Weizman
authors.forename: Abraham
authors.initials: A
authors.lastname: Weizman
mesh_terms: D000328:Adult; D001008:Anxiety Disorders / Q000175:diagnosis / Q000453:epidemiology; D015897:Comorbidity; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D006801:Humans; D008297:Male; D019964:Mood Disorders / Q000175:diagnosis / Q000453:epidemiology; D009771:Obsessive-Compulsive Disorder / Q000175:diagnosis / Q000453:epidemiology*; D015995:Prevalence; D012559:Schizophrenia / Q000175:diagnosis / Q000453:epidemiology*; D012720:Severity of Illness Index; D013001:Somatoform Disorders / Q000453:epidemiology