Potential influence of hormones in the development of slipped capital femoral epiphysis: a preliminary study.
The potential influence of hormonal imbalance on the development of slipped capital femoral epiphysis was assessed through a prospective clinical study. The serum levels of T3, T4, thyroid-stimulating hormone, testosterone, estradiol, dehydroepiandrosterone-sulfate, follicle-stimulating hormone, luteinizing hormone, human growth hormone, adrenal cortex hormone and cortisol were evaluated in seven boys and seven girls. Forty-three out of 154 hormonal determinations (27.9%) were abnormal. The results showed increased incidence of pathological values mainly in the levels of follicle-stimulating-hormone, luteinizing-hormone and testosterone. No patient had clinical findings of endocrinopathy. A (possibly) temporary hormonal disorder may play a potentially significant role in the development of slipped capital femoral epiphysis.
Papavasiliou
Kyriakos A
KA
3rd Orthopaedic Department, Aristotle University of Thessaloniki-Medical School, Papageorgiou General Hospital, Thessaloniki, Greece. kyrpap2005@yahoo.com
Kirkos
John M
JM
Kapetanos
George A
GA
Pournaras
John
J
D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000097:blood*; D002648:Child; D019314:Dehydroepiandrosterone Sulfate / Q000097:blood; D004839:Epiphyses, Slipped / Q000209:etiology*; D004958:Estradiol / Q000097:blood; D005260:Female; D005270:Femur Head; D005640:Follicle Stimulating Hormone / Q000097:blood; D012739:Gonadal Steroid Hormones / Q000097:blood*; D013006:Growth Hormone / Q000097:blood*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D011446:Prospective Studies; D013739:Testosterone / Q000097:blood; D013963:Thyroid Hormones / Q000097:blood*; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
D000305:Adrenal Cortex Hormones; D012739:Gonadal Steroid Hormones; D013963:Thyroid Hormones; D014284:Triiodothyronine; D013739:Testosterone; D004958:Estradiol; D019314:Dehydroepiandrosterone Sulfate; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D013972:Thyrotropin; D013006:Growth Hormone; D013974:Thyroxine; D006854:Hydrocortisone