title: Phenotypic analysis of hepatic T lymphocytes in a dog with chronic hepatitis.
abstract: We evaluated hepatic T lymphocyte phenotypes in a dog with chronic hepatitis. Before treatment, numerous CD3+ lymphocytes were demonstrated in the liver, and the ratio of CD4+/CD8+ was remarkably high (2.96; reference range, 0.33+/-0.12). After treatment, CD3+ lymphocyte infiltration in the liver was reduced, and the ratio of CD4+/CD8+ decreased to 0.31. Therefore, hepatic T lymphocytes, especially CD4+ lymphocytes, might play a central role in the pathogenesis of this dog with chronic hepatitis.
authors.affiliation: Laboratory of Comprehensive Veterinary Clinical Studies, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, Kanagawa, Japan.
authors.forename: Manabu
authors.initials: M
authors.lastname: Sakai
authors.forename: Isao
authors.initials: I
authors.lastname: Otani
authors.forename: Kumiko
authors.initials: K
authors.lastname: Ishigaki
authors.forename: Kazuya
authors.initials: K
authors.lastname: Edamura
authors.forename: Tomoko
authors.initials: T
authors.lastname: Takahashi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Koie
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Yamaya
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Watari
authors.forename: Hisashi
authors.initials: H
authors.lastname: Shibuya
authors.forename: Tsuneo
authors.initials: T
authors.lastname: Sato
authors.forename: Kiichi
authors.initials: K
authors.lastname: Kanayama
authors.forename: Mikihiko
authors.initials: M
authors.lastname: Tokuriki
authors.forename: Atsuhiko
authors.initials: A
authors.lastname: Hasegawa
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000818:Animals; D004283:Dog Diseases / Q000188:drug therapy* / Q000276:immunology*; D004285:Dogs; D006521:Hepatitis, Chronic / Q000188:drug therapy / Q000276:immunology / Q000662:veterinary*; D016130:Immunophenotyping / Q000662:veterinary*; D008099:Liver / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D000305:Adrenal Cortex Hormones