Inhibition of Staphylococcus aureus growth on tellurite-containing media by Lactobacillus reuteri Is dependent on CyuC and thiol production.
Lactobacillus reuteri inhibits Staphylococcus aureus growth on Baird-Parker agar. This activity required the presence of tellurite and was not shared with other lactic acid bacteria or an L. reuteri mutant defective in cystine metabolism. Secreted products generated from L. reuteri cystine metabolism and thiols were shown to augment tellurite toxicity.
Turner
Mark S
MS
Infectious Diseases Program, Cells and Tissue Domain, Institute for Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia. ms.turner@qut.edu.au
Lo
Raquel
R
Giffard
Philip M
PM
D000362:Agar; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D001431:Bacteriological Techniques; D003470:Culture Media; D003553:Cystine / Q000378:metabolism; D052200:Limosilactobacillus reuteri / Q000254:growth & development*; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000254:growth & development*; D013438:Sulfhydryl Compounds / Q000378:metabolism; D013691:Tellurium / Q000378:metabolism* / Q000494:pharmacology*
D001426:Bacterial Proteins; D003470:Culture Media; D013438:Sulfhydryl Compounds; D003553:Cystine; D000362:Agar; C026660:tellurous acid; D013691:Tellurium