title: [Study the safety and effectively of human thrombin after tonsillectomy].
abstract: OBJECTIVE
  To evaluate the safety and effectively of human thrombin after tonsillectomy.
  
  
  METHODS
  This was a prospective, randomized and controlled clinical trial. 80 cases of both tonsillectomies were divided into study group and control group. We evaluated the hemostatic role in study group: human thrombin has been insufflated locally in right side; physiological saline was in lift side. Observed the effects on the hemostatic time, hemorrhagic volume and hemorrhagic volume per square unit.
  
  
  RESULTS
  After two sides received different drugs in both tonsillectomies, in study group and control group, the average hemostatic time was (62.8 +/- 24.6) S and (94.7 +/- 36.9) S, the hemorrhagic volume was (4.9 +/- 6.7) g and (7.3 +/- 13.4) g, the hemorrhagic volume per square unit was (0.79 +/- 0.98) g/cm and (1.14 +/- 1.95) g x cm(-2), respectively. Two sides had the significant difference (P < 0.05). During the study, no adverse event was reported in two groups. The index of HBsAg, HIV, HCV and Syphilis in study group (10 cases) were not abnormalities after the thrombin had been insufflated 3 months.
  
  
  CONCLUSIONS
  Human thrombin had the better hemostatic role and security on the hemorrhage of capillary of tonsillectomy wound.
authors.affiliation: Department of Otolaryngology, Beijing Hospital, Beijing, 100730, China.
authors.forename: Xiaoyun
authors.initials: X
authors.lastname: Wang
authors.forename: Hong
authors.initials: H
authors.lastname: Chen
authors.forename: Yonggang
authors.initials: Y
authors.lastname: Liu
authors.forename: Wei
authors.initials: W
authors.lastname: Yue
authors.forename: Weining
authors.initials: W
authors.lastname: Huang
mesh_terms: D000293:Adolescent; D000328:Adult; D006489:Hemostatic Techniques; D006801:Humans; D008875:Middle Aged; D011446:Prospective Studies; D013917:Thrombin / Q000627:therapeutic use*; D014068:Tonsillectomy / Q000379:methods*; D055815:Young Adult
chemical_list: D013917:Thrombin