title: Cerebellar hypoplasia in three sibling cats after intrauterine or early postnatal parvovirus infection.
abstract: The present report describes the case of an intrauterine or early postnatal parvovirus infection with subsequent cerebellar hypoplasia in three kittens from the same litter. Clinical examination of affected cats revealed neurologic signs indicative of cerebellar ataxia. Due to poor prognosis, animals were euthanised and submitted for necropsy. Post mortem examination demonstrated variable degrees of cerebellar hypoplasia. Histologically, brain lesions were characterised by segmental loss of the external and internal granular layer and decreased numbers of Purkinje cells. Reactive proliferation of astrocytes in the central nervous system was verified by the detection of GFAP-expressing glial cells in affected areas using immunohistochemistry. Furthermore, parvovirus antigen was detected immunohistochemically in neuronal cells of the cerebellum, but not in other parts of the brain and spinal cord or non-neuronal tissues. The present report demonstrates the usefulness of post mortem examination and detection of viral antigen by immunohistochemistry for the discrimination of neurologic disorders in feline species. Neurologic deficiencies due to cerebellar hypoplasia caused by in utero or perinatal feline parvovirus infection should be taken into consideration as differential diagnoses for ataxia in neonatal and juvenile cats.
authors.affiliation: Institut für Pathologie der Tierärztlichen Hochschule Hannover, Germany.
authors.forename: F
authors.initials: F
authors.lastname: Aeffner
authors.forename: R
authors.initials: R
authors.lastname: Ulrich
authors.forename: L
authors.initials: L
authors.lastname: Schulze-Rückamp
authors.forename: A
authors.initials: A
authors.lastname: Beineke
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D002371:Cat Diseases / Q000635:transmission* / Q000821:virology; D002415:Cats; D002526:Cerebellar Diseases / Q000662:veterinary* / Q000821:virology; D002531:Cerebellum / Q000473:pathology / Q000821:virology; D017809:Fatal Outcome; D005260:Female; D007150:Immunohistochemistry / Q000662:veterinary; D018445:Infectious Disease Transmission, Vertical / Q000662:veterinary*; D010322:Parvoviridae Infections / Q000635:transmission / Q000662:veterinary*; D017992:Parvovirus / Q000276:immunology / Q000302:isolation & purification; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000662:veterinary* / Q000821:virology