Prooxidant-antioxidant state of the organism during oxidative stress and correction of the L-arginine-NO system.
The prooxidant-antioxidant balance in rats with oxidative stress was studied during correction of the L-arginine-NO system. Oxidative stress was induced by intravenous injection of E. coli lipopolysaccharide. Under conditions of oxidative stress the prooxidant-antioxidant imbalance was least pronounced during selective correction of the L-arginine-NO system. L-Arginine and nonselective NO synthase inhibitor had little protective effect.
Glebov
A N
AN
Department of Normal Physiology, Grodno Medical University.
Zinchuk
V V
VV
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001120:Arginine / Q000737:chemistry*; D008070:Lipopolysaccharides / Q000378:metabolism; D008297:Male; D008954:Models, Biological; D009569:Nitric Oxide / Q000737:chemistry*; D018384:Oxidative Stress; D051381:Rats; D017382:Reactive Oxygen Species / Q000494:pharmacology*
D000975:Antioxidants; D008070:Lipopolysaccharides; D017382:Reactive Oxygen Species; D009569:Nitric Oxide; D001120:Arginine