title: Synthesis of novel 4'-modified neplanocin A analogues based on radical-mediated sulfur-extrusive stannylation.
abstract: A new approach was developed for the synthesis of 4'-modified neplanocin A, as potential inhibitors against S-adenosyl-L-homocysteine hydrolase. Vinylstannane derivative 5, a key intermediate in the present approach, was prepared by radical-mediated sulfur-extrusive stannylation.
authors.affiliation: School of Pharmaceutical Sciences, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Kumamoto
authors.forename: Kazuki
authors.initials: K
authors.lastname: Deguchi
authors.forename: Nonoko
authors.initials: N
authors.lastname: Takahashi
authors.forename: Hiromichi
authors.initials: H
authors.lastname: Tanaka
mesh_terms: D000241:Adenosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D002623:Chemistry Techniques, Analytical / Q000379:methods*; D005609:Free Radicals / Q000737:chemistry*; D013455:Sulfur / Q000737:chemistry*; D017971:Tin Compounds / Q000737:chemistry*
chemical_list: D005609:Free Radicals; D017971:Tin Compounds; C031525:stannane; D013455:Sulfur; C031096:neplanocin A; D000241:Adenosine