Analysis of DNA damage generated by high-energy particles.
Ionizing radiation generates isolated and localized multiple (i.e., clustered) lesions in DNA, and the latter is believed to be primarily responsible for deleterious biological consequences such as cell killing and mutations. In the present study, we irradiated plasmid and lambda DNA by ionizing radiations with different linear energy transfer (LET) values, and compared the yields of isolated and clustered DNA lesions.
Terato
Hiroaki
H
Department of Mathematical and Life Sciences, Graduate School of Science, Hiroshima University, Higashi-Hiroshima 739-8526, Japan.
Tanaka
Ruri
R
Nakaarai
Yusuke
Y
Furusawa
Yoshiya
Y
Ide
Hiroshi
H
D002244:Carbon; D004249:DNA Damage; D005720:Gamma Rays; D007501:Iron; D018499:Linear Energy Transfer; D010957:Plasmids / Q000528:radiation effects; D011839:Radiation, Ionizing
D002244:Carbon; D007501:Iron