Down-regulation of c-FLIP increases reactive oxygen species, induces phosphorylation of serine/threonine kinase Akt, and impairs motility of cancer cells.
The role of c-FLIP in cell motility was investigated using RNA interference. Down-regulation of c-FLIP increased amounts of reactive oxygen species (ROS), while over-expression of c-FLIP produced opposite effect. ROS induced phosphorylation of Akt and impaired cell motility.
Shim
Eunsook
E
School of Biological Sciences, College of Natural Sciences, Kangwon National University, Chunchon, Korea.
Lee
Yun-Sil
YS
Kim
Hae Yeong
HY
Jeoung
Dooil
D
D053446:CASP8 and FADD-Like Apoptosis Regulating Protein / Q000378:metabolism*; D002465:Cell Movement; D015536:Down-Regulation; D006367:HeLa Cells; D006801:Humans; D051058:Oncogene Protein v-akt / Q000378:metabolism*; D010766:Phosphorylation; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000378:metabolism*
D053446:CASP8 and FADD-Like Apoptosis Regulating Protein; C506386:CFLAR protein, human; D017382:Reactive Oxygen Species; D051058:Oncogene Protein v-akt; D017346:Protein Serine-Threonine Kinases