title: 9,10-seco-9,19-Cyclolanostane arabinosides from the roots of Actaea podocarpa.
abstract: Seven 9,10-seco-9,19-cyclolanostane arabinosides, named podocarpasides A-G (1-7), were isolated from the roots of Actaea podocarpa DC., a species closely related to black cohosh (a well known dietary supplement). Their structures were determined with the help of spectroscopic data including extensive 2D NMR spectroscopy. The isolates were found inactive, when tested for cytotoxic, estrogenic, and antioxidant activities in cell based assays. They were also tested for anticomplement activity against the classical pathway of complement system and only podocarpaside C (3) inhibited modest complement activity with an IC50 value of 200 microM.
authors.affiliation: National Center for Natural Products Research, University of Mississippi, MS 38677, USA.
authors.forename: Zulfiqar
authors.initials: Z
authors.lastname: Ali
authors.forename: Shabana I
authors.initials: SI
authors.lastname: Khan
authors.forename: Frank R
authors.initials: FR
authors.lastname: Fronczek
authors.forename: Ikhlas A
authors.initials: IA
authors.lastname: Khan
mesh_terms: D002236:Carbohydrate Conformation; D018360:Crystallography, X-Ray; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification*; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D018517:Plant Roots / Q000737:chemistry*; D029626:Ranunculaceae / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared
chemical_list: D006027:Glycosides