[Comparative immunohistochemical study of invasive duct carcinoma and Paget's disease of the breast with c-erbB-2 overexpression].
Overexpression of c-erbB2 oncogen is observed in 90-100% of cases of Paget's cancer. In all cases, the overexpression is caused by gene amplification. The authors carried out an immun ohistochemrical study of c-erbB2 (HER2/neu)-positive breast tumors: Paget's cancer (and hence with gene amplification) and breast invasive duct cancer without gene amplification. Moreover, the authors identified a case of c-erbB2-negative Paget's cancer, the phenotype of which was compared with the phenotypes of two earlier groups of tumors. The findings suggest that only formation of c-erbB2 heterodimers that cannot cause an increase in proliferation on their own is observed in the study groups of tumors.
Petrov
S V
SV
Raskin
G A
GA
Khasanov
R Sh
RSh
Tsyplakov
D E
DE
D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology; D015820:Cadherins / Q000096:biosynthesis; D018270:Carcinoma, Ductal, Breast / Q000378:metabolism* / Q000473:pathology; D049109:Cell Proliferation; D004817:Epidermis / Q000378:metabolism / Q000473:pathology; D005260:Female; D006023:Glycoproteins / Q000096:biosynthesis; D006801:Humans; D018960:Hyaluronan Receptors / Q000096:biosynthesis; D007150:Immunohistochemistry; D010144:Paget's Disease, Mammary / Q000378:metabolism* / Q000473:pathology; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000096:biosynthesis*; D011960:Receptors, Estrogen / Q000096:biosynthesis; D011980:Receptors, Progesterone / Q000096:biosynthesis
D015820:Cadherins; D006023:Glycoproteins; D018960:Hyaluronan Receptors; D018719:Erb-b2 Receptor Tyrosine Kinases; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; C112697:CD44v6 antigen