Arylamine N-acetyltransferase responsible for acetylation of 2-aminophenols in Streptomyces griseus.
An arylamine N-acetyltransferase (NAT) responsible for the N acetylation of exogenous 3-amino-4-hydroxybenzoic acid in Streptomyces griseus was identified and characterized. This enzyme was distinct from other eukaryotic and bacterial NATs in that it acetylated various 2-aminophenol derivatives more effectively than it acetylated 5-aminosalicylic acid, and thus it may be involved in the metabolism of xenobiotic compounds.
Suzuki
Hirokazu
H
Department of Biotechnology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan.
Ohnishi
Yasuo
Y
Horinouchi
Sueharu
S
D000107:Acetylation; D062365:Aminobenzoates / Q000378:metabolism*; D000627:Aminophenols / Q000378:metabolism*; D001191:Arylamine N-Acetyltransferase / Q000235:genetics / Q000502:physiology*; D001483:Base Sequence; D004926:Escherichia coli / Q000235:genetics; D062385:Hydroxybenzoates; D008969:Molecular Sequence Data; D011994:Recombinant Proteins / Q000096:biosynthesis; D013305:Streptomyces griseus / Q000378:metabolism*; D013379:Substrate Specificity
D062365:Aminobenzoates; D000627:Aminophenols; D062385:Hydroxybenzoates; D011994:Recombinant Proteins; C110924:3-amino-4-hydroxybenzoic acid; C027667:2-aminophenol; D001191:Arylamine N-Acetyltransferase