Mechanisms leading to nonrandom, nonhomologous chromosomal translocations in leukemia.
Nonrandom, reciprocal translocations between nonhomologous chromosomes are critical cellular events that lead to malignant transformation. Therefore, understanding the mechanisms involved in these chromosomal rearrangements is essential for understanding the process of carcinogenesis. There has been substantial discussion in the literature over the past 10 years about mechanisms involved in constitutional chromosomal rearrangements, including deletions, duplications, and translocations. Yet our understanding of the mechanisms of chromosomal rearrangements in cancer is still developing. This review presents what is known about the mechanisms involved in selected nonrandom chromosomal translocations in leukemia.
Gollin
Susanne M
SM
Department of Human Genetics, University of Pittsburgh Graduate School of Public Health, 130 DeSoto Street, Room A302 Crabtree Hall, Pittsburgh, PA 15261, USA. sgollin@hgen.pitt.edu
D002467:Cell Nucleus / Q000378:metabolism; D002869:Chromosome Aberrations; D019457:Chromosome Breakage; D015973:Gene Expression Regulation, Leukemic; D006801:Humans; D007621:Karyotyping; D007938:Leukemia / Q000235:genetics*; D007945:Leukemia, Lymphoid; D008954:Models, Biological; D008957:Models, Genetic; D009369:Neoplasms / Q000235:genetics; D010677:Philadelphia Chromosome; D014178:Translocation, Genetic