Glutamine dipeptide for parenteral nutrition in abdominal surgery: a meta-analysis of randomized controlled trials.
OBJECTIVE
To assess the clinical and economical validity of glutamine dipeptide supplemented to parenteral nutrition (PN) in patients undergoing abdominal surgery.


METHODS
A meta-analysis of all the relevant randomized controlled trials (RCTs) was performed. The trials compared the standard PN and PN supplemented with glutamine dipeptide in abdominal surgery. RCTs were identified from the following electronic databases: the Cochrane Library, MEDLINE, EMBASE and ISI web of knowledge (SCI). The search was undertaken in April 2006. Literature references were checked by computer or hand at the same time. Clinical trials were extracted and evaluated by two reviewers independently. Statistical analysis was performed by RevMan4.2 software from Cochrane Collaboration. A P value of < 0.05 was considered statistically significant.


RESULTS
Nine RCTs involving 373 patients were included. The combined results showed that glutamine dipeptide has a positive effect in improving postoperative cumulative nitrogen balance (weighted mean difference (WMD = 8.35, 95% CI [2.98, 13.71], P = 0.002), decreasing postoperative infectious morbidity (OR = 0.24, 95% CI [0.06, 0.93], P = 0.04), shortening the length of hospital stay (WMD= -3.55, 95% CI [-5.26, -1.84], P < 0.00001). No serious adverse effects were found.


CONCLUSIONS
Postoperative PN supplemented with glutamine dipeptide is effective and safe to decrease the infectious rate, reduce the length of hospital stay and improve nitrogen balance in patients undergoing abdominal surgery. Further high quality trials in children and severe patients are required, and mortality and hospital cost should be considered in future RCTs with sufficient size and rigorous design.
Zheng
Ya-Min
YM
Department of General Surgery, Xuanwu Hospital, Capital Medical University, No.45 Changchun Street, Xuanwu District, Beijing 100053, China.
Li
Fei
F
Zhang
Ming-Ming
MM
Wu
Xiao-Ting
XT
D000005:Abdomen / Q000601:surgery; D019587:Dietary Supplements; D004151:Dipeptides / Q000008:administration & dosage*; D006801:Humans; D010288:Parenteral Nutrition / Q000379:methods*; D016032:Randomized Controlled Trials as Topic
D004151:Dipeptides; C054122:alanylglutamine