title: [Psychophysiologic disturbances in early postmenopause in women after physiological and surgical menopause].
abstract: OBJECTIVE
  The most common secondary manifestations of menopause are clinical manifestations of estrogen deficiency. They could be early and late. The aim of this study was to compare manifestations of somatic disturbances in early postmenopause in women after physiological and surgical menopause.
  
  
  METHODS
  This prospective study included 60 women, age 41-55 years, divided into two groups: physiological (30 of them) and surgically induced menopause. For every subject a special evidence list, consisting of the disease history questions, physical and gynecology examination as well as dates about physiological variables (arterial tension, height, weight, and body-mass index) and laboratory examination was formed. The values of arteriol blood pressure, body height, body mass, body mass index (BMI), and lipid status were determined and gynecological examinations were performed in each patient.
  
  
  RESULTS
  The most frequent symptoms in both groups were vasomotor ones. Headache was the more intensive sign in the group after induced menopause. Extrasistolyc heart excursion was a common symptom in both study groups. Arterial tension, regardless of the type of menopause, was in the physiological range. The frequent organic signs of menopause, more intensive in the group after induced menopause, were genitourinary and skin atrophy. An analysis of the BMI showed that the women in both groups were obese (BMI > 25). The lipids analysis confirmed the predomination of hyperlipoproteinemia type IIa in the group with physiologic menopause and type IIb after induced menopause.
  
  
  CONCLUSIONS
  The dominant signs of menopausal syndrome were vasomotor and bone-joint symptoms, more frequent in the group after induced menopause. There were no statistically significant differences between the study groups according to the genitourinary atrophy and other signs of aging. Menopausal hormonal changes, regardless of the way of menopause developing, increase the risk for hyperlipoproteinemia. The frequency of somatic signs in early post menopause is typically higher after induced menopause. More intensive follow-up in patients after surgical removing of the ovaria is necessary in order to improve the quality of life in these patients.
authors.affiliation: Klinika za operativnu onkologiju, Institut za onkologiju Sremska Kamenica, Srbija. dnincic@neobee.net
authors.forename: Dejan
authors.initials: D
authors.lastname: Nincić
authors.forename: Dragan
authors.initials: D
authors.lastname: Zikić
authors.forename: Tatjana
authors.initials: T
authors.lastname: Ivković-Kapicl
authors.forename: Katarina
authors.initials: K
authors.lastname: Mastilović
mesh_terms: D000328:Adult; D001284:Atrophy; D001823:Body Composition; D005260:Female; D019584:Hot Flashes; D006801:Humans; D008055:Lipids / Q000097:blood; D008594:Menopause, Premature / Q000502:physiology*; D008875:Middle Aged; D010052:Ovariectomy / Q000009:adverse effects; D017698:Postmenopause / Q000502:physiology*; D011788:Quality of Life; D012867:Skin / Q000473:pathology; D014566:Urogenital System / Q000473:pathology
chemical_list: D008055:Lipids