[Relationship between quinone oxidoreductase1 gene ns-cSNP and genetic susceptibility of esophageal cancer].
OBJECTIVE
To explore the relationship between quinone oxidoreductase1 (NQO1) gene nonsynonymous cSNP and the genetic susceptibility of esophageal cancer.


METHODS
Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and Allele-Specific PCR (AS-PCR) were employed to assess the polymorphism of NQO1 genes both in 106 patients with esophageal cancer and control subjects matched by age, gender and origin.


RESULTS
It was shown that no C/C genotype was found at 406 of NQO1. The allelic frequency of NQO1 609T was significantly higher in patients with esophageal cancer than in the control subjects (P < 0.005) and the individuals with 609T allelic genotype of NQO1 gene were at greater risk to develop esophageal cancer (OR = 4.76, 95% CI = 1.064 - 3.397). But Individuals with mutant allele of NQO1 465 genotype did not show the rising risk of esophageal cancer.


CONCLUSIONS
The NQO1 C609T polymorphisms should likely be associated with the genetic susceptibility of esophageal cancer.
Zhang
Wen-cui
WC
School of Public Health, Southeast University, Nanjing 210009, China.
Yin
Li-hong
LH
Pu
Yue-pu
YP
Liang
Ge-yu
GY
Hu
Xu
X
Liu
Yao-zhen
YZ
Cui
Yong-sheng
YS
D000483:Alleles; D002681:China; D004938:Esophageal Neoplasms / Q000208:ethnology / Q000235:genetics*; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D016660:NAD(P)H Dehydrogenase (Quinone) / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
D016660:NAD(P)H Dehydrogenase (Quinone); C447479:NQO1 protein, human