Synthesis of N-substituted indole derivatives via PIFA-mediated intramolecular cyclization.
[Structure: see text] A variety of N-arylated and N-alkylated indole derivatives were synthesized by way of a phenyliodine bis(trifluoroacetate) (PIFA)-mediated intramolecular cyclization. This novel method allows for the construction of an indole skeleton by joining the N-atom on the side chain to the benzene ring at the last synthetic step. Other novel pyrrole-fused aromatic compounds can also be achieved by this method.
Du
Yunfei
Y
College of Pharmaceuticals and Biotechnology, Tianjin University, 300072, PRC.
Liu
Renhe
R
Linn
Gregory
G
Zhao
Kang
K
D003500:Cyclization; D005463:Fluoroacetates; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D007462:Iodobenzenes; D014269:Trifluoroacetic Acid / Q000737:chemistry
D005463:Fluoroacetates; D007211:Indoles; D007462:Iodobenzenes; C517666:phenyliodine(III) bis(trifluoroacetate); D014269:Trifluoroacetic Acid