TGF-beta1 gene polymorphism in liver graft recipients.
Cytokines are known to be important mediators during liver graft outcome and their gene polymorphism could affect the overall expression and secretion of cytokines. In this retrospective study, we analyzed the effect of TGF-beta1 polymorphism in 150 liver allograft recipients. Genotyping PCR-SSP were performed for TGF-beta1 gene (codon 10T/C and 25C/G). TGF-beta1 polymorphism at codon 10 and 25 correlate borderline with liver graft acceptance and when the combination between codon 10 and 25 was analyzed, it revealed that T/T G/C genotype and the TC haplotype were significantly associated with graft acceptance (p<0.05). TGF-beta1 high secretor phenotype was also increased in the acute rejection group close to significance (p=0.06). In conclusion, these findings show a correlation between TGF-beta1 gene polymorphism and liver graft acceptance.
Gómez-Mateo
Jorge
J
Immunology, Hospital Universitario Virgen de la Arrixaca, 30120 Murcia, Spain.
Marin
Luis
L
López-Alvarez
María R
MR
Moya-Quiles
M Rosa
MR
Miras
Manuel
M
Marin-Moreno
Isabel
I
Botella
Carmen
C
Parrilla
Pascual
P
Alvarez-López
María R
MR
Muro
Manuel
M
D003062:Codon / Q000235:genetics; D005838:Genotype; D006085:Graft Survival / Q000235:genetics / Q000276:immunology; D006239:Haplotypes; D006801:Humans; D016031:Liver Transplantation / Q000276:immunology*; D020641:Polymorphism, Single Nucleotide; D011379:Prognosis; D053773:Transforming Growth Factor beta1 / Q000235:genetics*
D003062:Codon; D053773:Transforming Growth Factor beta1