Hybridization properties and enzymatic recognitions of naphthyridine:imidazopyridopyrimidine base pairs.
We describe the synthesis of 1,8-naphthyridine C-nucleosides, Na-N(O) and Na-O(N), and full details of hybridization properties of the duplexes containing naphthyridine:imidazopyridopyrimidine pairs. The desired compounds were obtained from Na-O(N) derivative 1 via conversions of the substituents of 2- and 7-positions, respectively. The 17mer duplex containing one Na-O(O):Im-N(N) pair in the center was stabilized by +11.4 degrees C relative to that containing a T:A pair, and this value was highest among the naphthyridine:imidazopyridopyrimidine pairs.
Ogata
Shintaro
S
Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo 060-0812, Japan.
Kuramoto
Kazuyuki
K
Inoue
Naonori
N
Minakawa
Noriaki
N
Matsuda
Akira
A
D020029:Base Pairing; D004247:DNA / Q000737:chemistry*; D004259:DNA-Directed DNA Polymerase / Q000378:metabolism; D007093:Imidazoles / Q000138:chemical synthesis / Q000737:chemistry*; D007211:Indoles / Q000138:chemical synthesis / Q000737:chemistry*; D009693:Nucleic Acid Hybridization; D009838:Oligodeoxyribonucleotides / Q000737:chemistry; D011758:Pyrroles / Q000138:chemical synthesis / Q000737:chemistry*
D007093:Imidazoles; D007211:Indoles; D009838:Oligodeoxyribonucleotides; D011758:Pyrroles; D004247:DNA; D004259:DNA-Directed DNA Polymerase