[Obesity, diabetes and insulin resistance. Alterations of insulin signalling].
Obesity is often associated with diabetes and insulin resistance. This review summarizes evidence obtained in our lab on the role of the serine phosphorylation of the insulin receptor substrate 1 in the down regulation of insulin signalling. The role of the ERK1 isoform in the development of adipose tissue and insulin sensitivity is also presented.
Le Marchand-Brustel
Yannick
Y
INSERM, U568, Faculté de Mèdecine, Université de Nice Sophia Antipolis, Avenue de Valombrose, 06107 Nice 02, France. lemarcha@unice.fr
Gual
Philippe
P
Aouadi
Myriam
M
Grémeaux
Thierry
T
Binétruy
Bernard
B
Bost
Frédéric
F
Tanti
Jean-François
JF
D000273:Adipose Tissue / Q000502:physiology / Q000503:physiopathology; D003920:Diabetes Mellitus / Q000503:physiopathology*; D006801:Humans; D007328:Insulin / Q000502:physiology*; D055504:Insulin Receptor Substrate Proteins; D007333:Insulin Resistance / Q000502:physiology*; D048052:Mitogen-Activated Protein Kinase 3 / Q000378:metabolism; D009765:Obesity / Q000503:physiopathology*; D010750:Phosphoproteins / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*
C526292:IRS1 protein, human; D007328:Insulin; D055504:Insulin Receptor Substrate Proteins; D010750:Phosphoproteins; D048052:Mitogen-Activated Protein Kinase 3