[ZNF217 gene was detected in ovarian serous cystadenocarcinoma by fluorescence in situ hybridization].
OBJECTIVE
To investigate amplification of zinc finger protein 217 (ZNF217) gene in ovarian serous cystadenocarcinoma and its clinical significance.


METHODS
Twenty three specimens of ovarian carcinoma, 10 specimens of ovarian benign tumors and 7 specimens of normal ovaries and two ovarian cancer cell lines, SKOV3 and HO-8910 were examined by fluorescence in situ hybridization (FISH).


RESULTS
The amplification of ZNF217 was gained in 12 case of ovarian cancers, there was only 1 case in ovarian benign tumor and not amplication in normal ovary.


CONCLUSIONS
The amplification of ZNF217 is associated with ovarian cancer. Oncogenes ZNF217 maybe play a role in cell differentiation and indicate poorer survival in patients with ovarian cancer.
Zhong
Mei
M
Department of Gynecology and Obstetrics, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, 510515, P. R. China. zhongmei@fimmu.com
Li
Jing
J
Ding
Yan-qing
YQ
Song
Lan-lin
LL
D000328:Adult; D000368:Aged; D002454:Cell Differentiation; D045744:Cell Line, Tumor; D018284:Cystadenocarcinoma, Serous / Q000235:genetics* / Q000473:pathology; D018293:Cystadenoma, Serous / Q000235:genetics / Q000473:pathology; D005260:Female; D005784:Gene Amplification; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008875:Middle Aged; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000235:genetics* / Q000473:pathology; D016019:Survival Analysis; D015534:Trans-Activators / Q000235:genetics*
D015534:Trans-Activators; C113698:ZNF217 protein, human