[Early diagnosis of endometrial precancer and cancer by combined use of progesterone test and transvaginal ultrasonography in high risk groups of patients with diabetes, blood hypertension, and obesity].
In our research work we decided to combine the use of progesterone challenge test and transvaginal sonography in women from the risky groups: diabetes mellitus, obesity and blood hypertension. Our research work was performed for 10 years period /1995 till 2005/. We have chosen the cut off point of 4 mm for endometrial thickness. In the group with diabetes we found 9 atypical glandular hyperplasias and 2 endometrial cancers. In the group with blood hypertension we found 6 atypical glandular hyperplasias and 1 endometrial cancer. The screening in the obesity group found 2 adenocancers and 8 atypical glandular hyperplasias. The sensitivity of our method was 95% and specificity 98%.
Ivanov
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D003920:Diabetes Mellitus / Q000000981:diagnostic imaging / Q000378:metabolism; D042241:Early Diagnosis; D016889:Endometrial Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000209:etiology / Q000378:metabolism; D019160:Endosonography; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000000981:diagnostic imaging / Q000378:metabolism; D009765:Obesity / Q000150:complications / Q000000981:diagnostic imaging / Q000378:metabolism; D011230:Precancerous Conditions / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000209:etiology / Q000378:metabolism; D011374:Progesterone / Q000032:analysis*; D012307:Risk Factors; D012680:Sensitivity and Specificity; D014599:Uterus / Q000000981:diagnostic imaging*
D011374:Progesterone