Synthesis and biological evaluation of some pyrrolo[2,3-d]pyrimidines.
Pyrrolo[2,3-d]pyrimidine and tetrazolopyrimidine derivatives 2a, b-5a, b were prepared. Also, acyclic and cyclic C-nucleosides 7a, b-12a, b were prepared by treating compound 6 with some aldoses. All prepared products were tested for antiviral activity against hepatitis-A virus (HAV, MBB-cell culture adapted strain) and herpes simplex virus type-1 (HSV-1). Plaque reduction infectivity assay was used to determine virus count reduction as a result of treatment with tested compounds. Compound 2a showed the highest effect on HAV, while compound 11b showed the highest effect on the HSV-1 virus.
Rashad
Aymn E
AE
Photochemistry Department, National Research Centre, Dokki, Ciro 1258943, Cairo, Egypt. aymnelzeny@yahoo.com
Mohamed
Mosaad S
MS
Zaki
Magdy E A
ME
Fatahala
Samar S
SS
D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D030041:Hepatitis A virus / Q000187:drug effects; D018259:Herpesvirus 1, Human / Q000187:drug effects; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology*; D011758:Pyrroles / Q000138:chemical synthesis* / Q000494:pharmacology*; D013056:Spectrophotometry, Ultraviolet; D010948:Viral Plaque Assay
D000998:Antiviral Agents; D007202:Indicators and Reagents; D011743:Pyrimidines; D011758:Pyrroles