[Breast-conserving therapy for centrally located primary breast cancer].
OBJECTIVE
The goal of the study is to investigate the feasibility of breast-conserving therapy for early primary breast carcinoma centrally located in the breast.


METHODS
157 patients with stage I or II primary breast cancer located in the central part of the breast were operated with extended local excision and axillary lymph node dissection. Nipple-areola complex was excised in 18 patients. Ninety-three patients received two to six cycles neo-adjuvant chemotherapy. Radiotherapy was given postoperatively to the whole remaining breast.


RESULTS
The clinical response rate was 87.1% (81/93) and pathologic complete remission rate was 15.1% (14/93) after neo-adjuvant chemotherapy. Breast conservation surgery was performed successfully for all the patients in this series. After a median follow-up of 23 months (range 6-53 months), there was no recurrence in the ipsilateral breast. The aesthetic effect of the conserved breast was satisfactory including excellent for 88 patients and good for 48 patients representing of 86.6% of all cases.


CONCLUSIONS
Breast conserving surgery is suitable for the early centrally located primary breast carcinoma. Though the short-term results are satisfactory, the long-term follow-up is still needed for the final outcome.
Li
Jin-Feng
JF
Breast Cancer Center, Peking Cancer Institute (Hospital), School of Oncology, Peking University, Beijing 100036, China. jinfeng_li@hotmail.com
Ouyang
Tao
T
Wang
Tian-Feng
TF
Xie
Yun-Tao
YT
Fan
Zhao-Qing
ZQ
Lin
Ben-Yao
BY
D000328:Adult; D000368:Aged; D001365:Axilla; D001943:Breast Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery*; D018270:Carcinoma, Ductal, Breast / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery*; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D005240:Feasibility Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008197:Lymph Node Excision; D008207:Lymphatic Metastasis; D015412:Mastectomy, Segmental / Q000379:methods*; D008875:Middle Aged; D012074:Remission Induction; D016896:Treatment Outcome