title: Can routine clinical markers be used longitudinally to monitor antiretroviral therapy success in resource-limited settings?
abstract: Although routine clinical markers are used routinely to determine the stage of human immunodeficiency virus (HIV) disease, their use in monitoring response to antiretroviral therapy is poorly defined. Selected clinical markers were evaluated for their ability to predict first-line antiretroviral therapy success. No clinically meaningful variables were identified that predicted virologic or immunological success, implying that the CD4+ cell count and HIV type 1 RNA level data are required for optimal management of antiretroviral therapy.
authors.affiliation: Division of Geographic Medicine and Center for AIDS Research, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
authors.forename: Shashwatee
authors.initials: S
authors.lastname: Bagchi
authors.forename: Mirjam C
authors.initials: MC
authors.lastname: Kempf
authors.forename: Andrew O
authors.initials: AO
authors.lastname: Westfall
authors.forename: Anastasiya
authors.initials: A
authors.lastname: Maherya
authors.forename: James
authors.initials: J
authors.lastname: Willig
authors.forename: Michael S
authors.initials: MS
authors.lastname: Saag
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D015415:Biomarkers / Q000032:analysis*; D018791:CD4 Lymphocyte Count; D003906:Developing Countries; D005260:Female; D015658:HIV Infections / Q000188:drug therapy* / Q000276:immunology / Q000821:virology; D015497:HIV-1 / Q000502:physiology; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D018655:Lymphocyte Count; D008297:Male; D008875:Middle Aged; D010976:Platelet Count; D012367:RNA, Viral / Q000097:blood; D016896:Treatment Outcome; D019562:Viral Load
chemical_list: D019380:Anti-HIV Agents; D015415:Biomarkers; D006454:Hemoglobins; D012367:RNA, Viral