Inhibition of hepatitis C IRES-mediated gene expression by small hairpin RNAs in human hepatocytes and mice.
The ability of small hairpin RNAs (shRNAs) to inhibit hepatitis C virus internal ribosome entry site (HCV IRES)-dependent gene expression was investigated in cultured cells and a mouse model. The results indicate that shRNAs, delivered as naked RNA or expressed from vectors, may be effective agents for the control of HCV and related viruses.
Ilves
Heini
H
SomaGenics, Inc., Santa Cruz, CA 95060, USA.
Kaspar
Roger L
RL
Wang
Qian
Q
Seyhan
Attila A
AA
Vlassov
Alexander V
AV
Contag
Christopher H
CH
Leake
Devin
D
Johnston
Brian H
BH
D000818:Animals; D000998:Antiviral Agents; D002478:Cells, Cultured; D015870:Gene Expression; D015316:Genetic Therapy; D006526:Hepatitis C / Q000235:genetics / Q000628:therapy*; D022781:Hepatocytes; D006801:Humans; D051379:Mice; D034741:RNA, Small Interfering / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use
D000998:Antiviral Agents; D034741:RNA, Small Interfering