title: Osteoporosis: differences and similarities in male and female patients.
abstract: Osteoporosis is associated with decreased bone strength as a consequence of decreased bone density and altered quality. It is a result of a disruption of balance between bone breakdown and bone formation, caused by increased bone resorption by osteoclasts or without appropriate screening, one's first awareness of the disease is a fracture. It results in increased mortality and significant morbidity. In the last decade, great strides have been made in defining the diagnosis and establishing effective modes of treatment for this disorder. Our current state of knowledge indicates that although this disease affects both sexes, there are clear differences that have clinical importance.
authors.affiliation: Department of Orthopedic Surgery, Weill Medical College of Cornell University, 1300 York Avenue, New York 10021, NY, USA. lanej@hss.edu <lanej@hss.edu>
authors.forename: Joseph Michael
authors.initials: JM
authors.lastname: Lane
authors.forename: Alana Carey
authors.initials: AC
authors.lastname: Serota
authors.forename: Bradley
authors.initials: B
authors.lastname: Raphael
mesh_terms: D015519:Bone Density; D050071:Bone Density Conservation Agents / Q000627:therapeutic use; D004164:Diphosphonates / Q000627:therapeutic use; D004967:Estrogens / Q000502:physiology; D005260:Female; D050723:Fractures, Bone / Q000453:epidemiology; D006620:Hip Fractures / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D008297:Male; D010024:Osteoporosis / Q000175:diagnosis / Q000453:epidemiology* / Q000503:physiopathology / Q000628:therapy; D012307:Risk Factors; D012727:Sex Characteristics; D012737:Sex Factors; D013718:Tensile Strength; D019379:Teriparatide / Q000627:therapeutic use
chemical_list: D050071:Bone Density Conservation Agents; D004164:Diphosphonates; D004967:Estrogens; D019379:Teriparatide