title: Structural effect of cationic copolymers on nucleic acid-chaperoning activity.
abstract: In order to evaluate the effect of cationic copolymer structures on their nucleic acid-chaperoning activity, we prepared various copolymers having different cationic residues or backbone molecular weight. It was revealed that nucleic acid-chaperoning activity increases with increasing molecular weight of the copolymer backbone and that the copolymer having the guanidino groups is effective for increasing nucleic acid-chaperoning activity. Compared with PLL-g-Dex, GPLL-g-Dex has weak activity to stabilize ds DNA. This weak stabilization effect of GPLL-g-Dex may contribute to the higher accelerating effect.
authors.affiliation: Institute for Materials Chemistry and Engineering, Kyushu University, 6-10-1 Hakozaki, Fukuoka 812-8581, Japan.
authors.forename: Kaoru
authors.initials: K
authors.lastname: Takada
authors.forename: Sung Won
authors.initials: SW
authors.lastname: Choi
authors.forename: Asako
authors.initials: A
authors.lastname: Yamayoshi
authors.forename: Arihiro
authors.initials: A
authors.lastname: Kano
authors.forename: Atsushi
authors.initials: A
authors.lastname: Maruyama
mesh_terms: D004247:DNA / Q000737:chemistry*; D003911:Dextrans / Q000737:chemistry*; D018832:Molecular Chaperones / Q000737:chemistry*; D011107:Polylysine / Q000031:analogs & derivatives* / Q000737:chemistry; D013329:Structure-Activity Relationship
chemical_list: D003911:Dextrans; D018832:Molecular Chaperones; C113090:poly(lysine)-graft-dextran; C520216:polylysine-graft-poly(N(epsilon)-amidinolysine)-graft-dextran; D011107:Polylysine; D004247:DNA