Biomechanical signals suppress proinflammatory responses in cartilage: early events in experimental antigen-induced arthritis.
Although biomechanical signals generated during joint mobilization are vital in maintaining integrity of inflamed cartilage, the molecular mechanisms of their actions are little understood. In an experimental model of arthritis, we demonstrate that biomechanical signals are potent anti-inflammatory signals that repress transcriptional activation of proinflammatory genes and augment expression of anti-inflammatory cytokine IL-10 to profoundly attenuate localized joint inflammation.
Ferretti
Mario
M
Section of Oral Biology, Department of Orthopedics, Ohio State University, 305 West 12th Avenue, Columbus, OH 43210, USA.
Gassner
Robert
R
Wang
Zheng
Z
Perera
Priyangi
P
Deschner
James
J
Sowa
Gwendolyn
G
Salter
Robert B
RB
Agarwal
Sudha
S
D000818:Animals; D000941:Antigens / Q000502:physiology*; D001169:Arthritis, Experimental / Q000473:pathology*; D002356:Cartilage / Q000473:pathology*; D007249:Inflammation / Q000235:genetics; D016753:Interleukin-10 / Q000235:genetics; D008297:Male; D040542:Mechanotransduction, Cellular / Q000502:physiology*; D011817:Rabbits; D015533:Transcriptional Activation
D000941:Antigens; D016753:Interleukin-10