title: [Liver damage in treatment of latent tuberculous infection by isoniazid].
abstract: OBJECTIVE
  To study the frequency and degree of liver damage as adverse effect of isoniazid (INH) preventive therapy in Japanese people.
  
  
  OBJECTIVE
  Chart review of Japanese persons who started isoniazid preventive chemotherapy in the two clinics in Tokyo, from 2003/1/1 to 2004/12/31.
  
  
  RESULTS
  There were 779 cases who did not transiently or completely stop INH preventive therapy because of adverse effect, and 26 cases who stopped INH transiently or completely because of liver damage as adverse effect (total 805 cases). In 371 cases, of those 779 cases, AST (asparate aminotransferase) and ALT (alanine aminotransferase) was measured after starting INH at least once. In 14.9% (59/397) of these 391 cases (= 371 + 26), liver damage as adverse effect was found. In 1.51% (6/397), liver damage with AST and/or ALT higher than 400 IU/L was found. Clinical hepatitis, associated with clinical symptom of hepatitis, was seen in 0.37% (3/805). Hepatitis with liver failure was seen in 0.12%. There was no death due to liver damage.
  
  
  CONCLUSIONS
  Liver damage as adverse effect of isoniazid (INH) preventive therapy in Japanese people is not rare.
authors.affiliation: Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association (JATA). ito@jata.or.jp
authors.forename: Kunihiko
authors.initials: K
authors.lastname: Ito
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Hoshino
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Nakazono
authors.forename: Hidenori
authors.initials: H
authors.lastname: Masuyama
authors.forename: Hironobu
authors.initials: H
authors.lastname: Sugita
authors.forename: Takashi
authors.initials: T
authors.lastname: Yoshiyama
authors.forename: Seiya
authors.initials: S
authors.lastname: Kato
mesh_terms: D000293:Adolescent; D000328:Adult; D000995:Antitubercular Agents / Q000009:adverse effects*; D044466:Asian People; D056486:Chemical and Drug Induced Liver Injury; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D007538:Isoniazid / Q000009:adverse effects*; D007564:Japan / Q000453:epidemiology; D008107:Liver Diseases / Q000175:diagnosis / Q000453:epidemiology; D014376:Tuberculosis / Q000517:prevention & control*
chemical_list: D000995:Antitubercular Agents; D007538:Isoniazid