Convenient synthesis of 3',5'-cyclic diguanylic acid (cdiGMP).
We herein report a convenient synthesis of 3',5'-cyclic diguanylic acid (cdiGMP) through the modified H-phosphonate chemistry. The 1-(4-chlorophenyl)-4-ethoxypiperidin-4-yl (Cpep) group was used as protecting group for the 2'-hydroxy functions of ribonucleosides. Homogeneous cdiGMP was obtained after removal of the protecting groups.
Yan
Hongbin
H
Department of Chemistry, Brock University, 500 Glenridge Ave., St. Catharines, Ontario L2S 3A1, Canada.
Humes
Eric
E
D002851:Chromatography, High Pressure Liquid; D006152:Cyclic GMP / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry
C062025:bis(3',5')-cyclic diguanylic acid; D006152:Cyclic GMP