title: Use of physiological doses of human growth hormone in haematological patients receiving intensive chemotherapy promotes haematopoietic recovery: a double-blind randomized, placebo-controlled study.
abstract: In vivo and in vitro studies suggest human growth hormone (hGH) receptors on bone marrow stem cells may be biologically active and could be exploited to promote haemopoetic recovery after intensive chemotherapy. Patients with haematological malignancies receiving intensive chemotherapy and requiring hospitalization were randomized in a double-blind, placebo-controlled single-centre trial. Patients were randomly assigned to receive either hGH 500 microg/day or placebo, for 6 weeks. There was no significant difference in patient characteristics at baseline between the placebo and treatment arms. Patients treated with hGH showed significantly faster recovery of platelets to 25 x 10(9)/l (median of 16 versus 19 days; P = 0.03) compared to the placebo-controlled arm (hazard ratio 1.47 favouring hGH, 95% confidence interval (CI), 1.03-2.08). Time to relapse did not differ significantly between arms. There was no change in the anthropometric parameters at the start and end of hGH/placebo therapy. The study drug was well tolerated. Treatment with hGH in physiological doses improves platelet recovery, but is not associated with a lower relapse rate or improved anthropometric parameters in patients receiving intensive chemotherapy.
authors.affiliation: Haemato-Oncology Unit, Royal Marsden Hospital and Institute of Cancer Research, Sutton, Surrey, UK.
authors.forename: B
authors.initials: B
authors.lastname: Sirohi
authors.forename: R
authors.initials: R
authors.lastname: Powles
authors.forename: G
authors.initials: G
authors.lastname: Morgan
authors.forename: J
authors.initials: J
authors.lastname: Treleaven
authors.forename: S
authors.initials: S
authors.lastname: Kulkarni
authors.forename: C
authors.initials: C
authors.lastname: Horton
authors.forename: R
authors.initials: R
authors.lastname: Saso
authors.forename: D
authors.initials: D
authors.lastname: Rolfe
authors.forename: G
authors.initials: G
authors.lastname: Cook
authors.forename: C
authors.initials: C
authors.lastname: Shaw
authors.forename: J
authors.initials: J
authors.lastname: Wass
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D018592:Cross-Over Studies; D004311:Double-Blind Method; D005260:Female; D006402:Hematologic Diseases / Q000188:drug therapy*; D006410:Hematopoiesis / Q000187:drug effects*; D019382:Human Growth Hormone / Q000627:therapeutic use*; D006801:Humans; D007938:Leukemia / Q000473:pathology / Q000628:therapy*; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000473:pathology / Q000628:therapy*; D009367:Neoplasm Staging; D010919:Placebos; D010976:Platelet Count; D012008:Recurrence; D014916:Whole-Body Irradiation
chemical_list: D010919:Placebos; D019382:Human Growth Hormone