Synthesis and biological evaluation of some 6-substituted purines.
We report herein the synthesis and the in vitro antileishmanial evaluation of a series of 6-substituted purines. The most active compounds against Leishmania amazonensis promastigotes were 6-(3'-chloropropylthio)purine 2 [11,12] [corrected] 6-(3'-(thioethylamine)propylthio)purine 5, 6-(alpha-aceticacidthio)purine 7 and 6-(6'-deoxy-1'-O-methyl-beta-D-ribofuranose)purine 14 with an IC(50)=50, 50, 39 and 29 microM, respectively.
Braga
Fernanda Gambogi
FG
Departamento de Parasitologia, Microbiologia e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Juiz de Fora, Campus Universitario, Bairro Martelos, Juiz de Fora, Minas Gerais 36036-900, Brazil.
Coimbra
Elaine Soares
ES
de Oliveira Matos
Magnum
M
Lino Carmo
Arturene Maria
AM
Cancio
Marisa Damato
MD
da Silva
Adilson David
AD
D000818:Animals; D005021:Ethylamines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D007891:Leishmania / Q000187:drug effects*; D008264:Macrophages / Q000187:drug effects; D051379:Mice; D015394:Molecular Structure; D021261:Parasitic Sensitivity Tests; D011687:Purines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
C527447:6-(3'-(thioethylamine)propylthio)purine; C527444:6-(3'-chloropropylthio)purine; C527446:6-(6'-deoxy-1'-O-methyl-beta-D-ribofuranose)purine; D005021:Ethylamines; D011687:Purines