Properties and application of oligodeoxynucleotides containing the naphthyridine:imidazopyridopyrimidine base pairs with the ability to form four hydrogen bonds.
As our continuing study to develop base pairing motifs which stabilize and regulate DNA structure, we designed novel 1,8-naphthyridine C-nucleosides possessing Na-O(N) and Na-N(O) bases. These C-nucleosides formed two sets of naphthyridine:imidazopyridopyrimidine base pairing motifs (Na-O(N):Im-N(O) and Na-N(O):Im-O(N)) with four hydrogen bonds, and duplexes containing the pairs were markedly thermally stabilized independent of the manner in which the new pairs are incorporated.
Hikishima
Sadao
S
Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo 060-0812, Japan.
Kuramoto
Kazuyuki
K
Minakawa
Noriaki
N
Matsuda
Akira
A
D020029:Base Pairing; D001483:Base Sequence; D006860:Hydrogen Bonding; D007093:Imidazoles / Q000737:chemistry*; D008969:Molecular Sequence Data; D009287:Naphthyridines / Q000737:chemistry*; D009838:Oligodeoxyribonucleotides / Q000737:chemistry* / Q000235:genetics; D011728:Pyridones / Q000737:chemistry*; D011743:Pyrimidines / Q000737:chemistry*
D007093:Imidazoles; D009287:Naphthyridines; D009838:Oligodeoxyribonucleotides; D011728:Pyridones; D011743:Pyrimidines