title: Biomechanical signals suppress proinflammatory responses in cartilage: early events in experimental antigen-induced arthritis.
abstract: Although biomechanical signals generated during joint mobilization are vital in maintaining integrity of inflamed cartilage, the molecular mechanisms of their actions are little understood. In an experimental model of arthritis, we demonstrate that biomechanical signals are potent anti-inflammatory signals that repress transcriptional activation of proinflammatory genes and augment expression of anti-inflammatory cytokine IL-10 to profoundly attenuate localized joint inflammation.
authors.affiliation: Section of Oral Biology, Department of Orthopedics, Ohio State University, 305 West 12th Avenue, Columbus, OH 43210, USA.
authors.forename: Mario
authors.initials: M
authors.lastname: Ferretti
authors.forename: Robert
authors.initials: R
authors.lastname: Gassner
authors.forename: Zheng
authors.initials: Z
authors.lastname: Wang
authors.forename: Priyangi
authors.initials: P
authors.lastname: Perera
authors.forename: James
authors.initials: J
authors.lastname: Deschner
authors.forename: Gwendolyn
authors.initials: G
authors.lastname: Sowa
authors.forename: Robert B
authors.initials: RB
authors.lastname: Salter
authors.forename: Sudha
authors.initials: S
authors.lastname: Agarwal
mesh_terms: D000818:Animals; D000941:Antigens / Q000502:physiology*; D001169:Arthritis, Experimental / Q000473:pathology*; D002356:Cartilage / Q000473:pathology*; D007249:Inflammation / Q000235:genetics; D016753:Interleukin-10 / Q000235:genetics; D008297:Male; D040542:Mechanotransduction, Cellular / Q000502:physiology*; D011817:Rabbits; D015533:Transcriptional Activation
chemical_list: D000941:Antigens; D016753:Interleukin-10