Characterization of Na+-montmorillonite-catalyzed reaction of racemic ribonucleotides.
We have reported that the oligomerization of racemic mononucleotides catalyzed by montmorillonite clay proceeds efficiently and gives up to 8-mer. Here, we attempted to identify the dimer products to show the characteristics of the racemic reaction. The results suggested that homochiral pApAs are formed in somewhat higher yield than heterochiral pApAs. Therefore, the oligomerization of racemic mononucleotides catalyzed by montmorillonite shows the homochiral selectivity.
Urata
Hidehito
H
Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan.
Fujimori
Mami
M
Aono
Chie
C
Hrada
Emi
E
Matsumoto
Tomoko
T
Yamakawa
Tomomi
T
Akagi
Masao
M
D000249:Adenosine Monophosphate / Q000031:analogs & derivatives* / Q000737:chemistry; D001546:Bentonite / Q000737:chemistry*; D002384:Catalysis; D002851:Chromatography, High Pressure Liquid; D019281:Dimerization; D007093:Imidazoles / Q000737:chemistry*; D012265:Ribonucleotides / Q000737:chemistry; D012964:Sodium / Q000737:chemistry; D013237:Stereoisomerism
D007093:Imidazoles; D012265:Ribonucleotides; C520193:adenosine 5'-phosphorimidazolide; D001546:Bentonite; D000249:Adenosine Monophosphate; D012964:Sodium