title: A highly effective one-pot synthesis of quinolines from o-nitroarylcarbaldehydes.
abstract: A highly effective one-pot Friedländer quinoline synthesis using inexpensive reagents has been developed. o-Nitroarylcarbaldehydes were reduced to o-aminoarylcarbaldehydes with iron in the presence of catalytic HCl (aq.) and subsequently condensed in situ with aldehydes or ketones to form mono- or di-substituted quinolines in high yields (66-100%).
authors.affiliation: Department of Cancer Chemistry, OSI Pharmaceuticals, Inc., 1 Bioscience Park Drive, Farmingdale, NY 11735, USA. ali@osip.com
authors.forename: An-Hu
authors.initials: AH
authors.lastname: Li
authors.forename: Eilaf
authors.initials: E
authors.lastname: Ahmed
authors.forename: Xin
authors.initials: X
authors.lastname: Chen
authors.forename: Matthew
authors.initials: M
authors.lastname: Cox
authors.forename: Andrew P
authors.initials: AP
authors.lastname: Crew
authors.forename: Han-Qing
authors.initials: HQ
authors.lastname: Dong
authors.forename: Meizhong
authors.initials: M
authors.lastname: Jin
authors.forename: Lifu
authors.initials: L
authors.lastname: Ma
authors.forename: Bijoy
authors.initials: B
authors.lastname: Panicker
authors.forename: Kam W
authors.initials: KW
authors.lastname: Siu
authors.forename: Arno G
authors.initials: AG
authors.lastname: Steinig
authors.forename: Kathryn M
authors.initials: KM
authors.lastname: Stolz
authors.forename: Paula A R
authors.initials: PA
authors.lastname: Tavares
authors.forename: Brian
authors.initials: B
authors.lastname: Volk
authors.forename: Qinghua
authors.initials: Q
authors.lastname: Weng
authors.forename: Doug
authors.initials: D
authors.lastname: Werner
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Mulvihill
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D001547:Benzaldehydes / Q000737:chemistry*; D007501:Iron / Q000737:chemistry; D007659:Ketones / Q000737:chemistry; D015394:Molecular Structure; D010084:Oxidation-Reduction; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000447:Aldehydes; D001547:Benzaldehydes; D007659:Ketones; D011804:Quinolines; C043850:2-nitrobenzaldehyde; D007501:Iron