Organocatalytic asymmetric michael addition of aldehydes to beta-nitroacroleine dimethyl acetal.
[Structure: see text] The organocatalytic asymmetric Michael addition of aldehydes to beta-nitroacroleine dimethyl acetal has been studied in detail. The reaction took place with excellent yields and high stereoselectivities when a chiral beta-amino alcohol such as L-prolinol was employed as the catalyst, leaving a formation of highly functionalized enantioenriched compounds containing two differentiated formyl groups together with a nitro moiety.
Reyes
Efraim
E
Department of Organic Chemistry II, Faculty of Science and Technology, University of the Basque Country, P.O. Box 644, 48080 Bilbao, Spain.
Vicario
Jose L
JL
Badía
Dolores
D
Carrillo
Luisa
L