title: Expression of androgen and estrogen receptors in human scalp mesenchymal cells in vitro.
abstract: The expression levels of sex hormone receptors were identified to be different in human mesenchymal cells [dermal papilla cell (DPC), dermal sheath cell (DSC), dermal fibroblast and (DF)] from occipital scalps. Transcriptional and translational activities of androgen receptor (AR) and estrogen receptor beta (ERbeta) were most intensely expressed in DPC, followed by DSC and DF. On the contrary, estrogen receptor alpha (ERalpha) was shown with the strongest positivity in DSC, succeeded by DPC and DF subsequently. Immunocytochemical staining showed the similar expression to previous patterns. Our results suggest that the expression levels of ER subtypes and AR may be important for the regulation of follicular mesenchymal cells in human scalp. Further studies of the interactions of hormones and receptors in human hair follicles are required to promote our understanding of the effects of sex hormones on hair biology.
authors.affiliation: Department of Dermatology, Seoul National University College of Medicine, Yongon-Dong 28, Chongno-Gu, 110-744 Seoul, South Korea.
authors.forename: Hyeon Gyeong
authors.initials: HG
authors.lastname: Yoo
authors.forename: Chong Hyun
authors.initials: CH
authors.lastname: Won
authors.forename: Se Rah
authors.initials: SR
authors.lastname: Lee
authors.forename: Oh Sang
authors.initials: OS
authors.lastname: Kwon
authors.forename: Kyu Han
authors.initials: KH
authors.lastname: Kim
authors.forename: Hee Chul
authors.initials: HC
authors.lastname: Eun
authors.forename: Kwang Hyun
authors.initials: KH
authors.lastname: Cho
mesh_terms: D000328:Adult; D002478:Cells, Cultured; D047628:Estrogen Receptor alpha / Q000378:metabolism*; D047629:Estrogen Receptor beta / Q000378:metabolism*; D018859:Hair Follicle / Q000254:growth & development; D006801:Humans; D008297:Male; D008648:Mesoderm / Q000166:cytology / Q000378:metabolism*; D011944:Receptors, Androgen / Q000378:metabolism*; D012535:Scalp / Q000166:cytology / Q000378:metabolism*
chemical_list: D047628:Estrogen Receptor alpha; D047629:Estrogen Receptor beta; D011944:Receptors, Androgen