title: Enhanced covariance spectroscopy from minimal datasets.
abstract: A novel approach is described for the determination of reliable high-resolution homonuclear NMR covariance spectra from minimal datasets. It uses a sparse sampling scheme along the indirect dimension together with a comprehensive analysis of finite sampling effects that eliminates spurious correlations. The scheme, which is demonstrated for TOCSY and COSY, offers a substantial speed up over current methods, rendering it suitable for high-throughput screening applications.
authors.affiliation: Department of Chemistry and Biochemistry, National High Magnetic Field Laboratory, Florida State University, Tallahassee, Florida 32306, USA.
authors.forename: Yanbin
authors.initials: Y
authors.lastname: Chen
authors.forename: Fengli
authors.initials: F
authors.lastname: Zhang
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Bermel
authors.forename: Rafael
authors.initials: R
authors.lastname: Brüschweiler
mesh_terms: D007089:Image Enhancement / Q000379:methods*; D019906:Nuclear Magnetic Resonance, Biomolecular / Q000379:methods*; D010456:Peptides, Cyclic / Q000737:chemistry*; D011487:Protein Conformation
chemical_list: D010456:Peptides, Cyclic; C100265:antamanide