title: Hyponatremia, hypophosphatemia, and hypouricemia in a girl with macrophage activation syndrome.
abstract: Macrophage activation syndrome, a life-threatening complication of rheumatic disorders, is accompanied by the overproduction of cytokines. We describe a girl with macrophage activation syndrome complicating systemic-onset juvenile arthritis who developed hyponatremia, hypophosphatemia, and hypouricemia associated with a high level of serum tumor necrosis factor alpha. Renal proximal tubule dysfunction was considered to be the cause, which may be attributable to tumor necrosis factor alpha.
authors.affiliation: Department of Pediatrics, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.
authors.forename: Kazuki
authors.initials: K
authors.lastname: Yamazawa
authors.forename: Kazuki
authors.initials: K
authors.lastname: Kodo
authors.forename: Jun
authors.initials: J
authors.lastname: Maeda
authors.forename: Sayu
authors.initials: S
authors.lastname: Omori
authors.forename: Mariko
authors.initials: M
authors.lastname: Hida
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Mori
authors.forename: Midori
authors.initials: M
authors.lastname: Awazu
mesh_terms: D005260:Female; D006801:Humans; D007010:Hyponatremia / Q000209:etiology*; D017674:Hypophosphatemia / Q000209:etiology*; D007223:Infant; D008262:Macrophage Activation; D008659:Metabolic Diseases / Q000097:blood / Q000209:etiology*; D013577:Syndrome; D014527:Uric Acid / Q000097:blood*
chemical_list: D014527:Uric Acid