title: Immune reactions and allergy in experimental anisakiasis.
abstract: The third-stage larvae (L3) of the parasitic nematode, Anisakis simplex, have been implicated in the induction of hyperimmune allergic reactions in orally infected humans. In this work, we have conducted a review of an investigation into immune reactions occurring in animals experimentally infected with A. simplex L3. The patterns of serum antibody productions in the experimental animals against excretory-secretory products (ESP) of A. simplex L3 contributed to our current knowledge regarding specific humoral immune reactions in humans. In our review, we were able to determine that L3 infection of experimental animals may constitute a good model system for further exploration of immune mechanisms and allergy in anisakiasis of humans.
authors.affiliation: Department of Parasitology, Korea University College of Medicine, Seoul, Korea. csw0419@korea.ac.kr
authors.forename: Sung-Weon
authors.initials: SW
authors.lastname: Cho
authors.forename: Haneul Nari
authors.initials: HN
authors.lastname: Lee
mesh_terms: D000818:Animals; D017129:Anisakiasis / Q000276:immunology; D017163:Anisakis / Q000254:growth & development / Q000276:immunology*; D000947:Antigens, Helminth / Q000276:immunology; D004195:Disease Models, Animal; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D006967:Hypersensitivity / Q000209:etiology* / Q000276:immunology; D007073:Immunoglobulin E / Q000097:blood; D007814:Larva / Q000276:immunology; D051379:Mice; D051381:Rats
chemical_list: D000947:Antigens, Helminth; D007073:Immunoglobulin E