title: Volume and dose effects of experimenter-administered ethanol preloads on ethanol seeking and self-administration.
abstract: The present experiment used a behavioral model developed to separate the initial behavior required to obtain access to ethanol (appetitive responding or lever presses) from the actual self-administration (consummatory responding or intake) to test the hypothesis that these responses are under the control of different behavioral/physiological processes, and therefore differentially affected by an ethanol priming dose. In male, Long Evans rats, "preload" volume (0.5 and 2.0ml) and dose (approximately 10%, 25%, and 50% of the total normally consumed in nontreatment sessions translating to 0.1, 0.25, and 0.5g/kg) of ethanol were varied and administered by the experimenter via oral gavage prior to an operant session. Overall, there were no priming effects, or increases, in ethanol-reinforced responding resulting from the ethanol preloads. The findings showed that the low preload volume produced linear, dose-dependent decreases in both intake and seeking. However, while the high volume also produced a linear dose-dependent decrease in ethanol seeking, there was a decrease in intake at every dose. That is, ethanol seeking was insensitive to preload volume, while intake was affected in a dose-dependent manner except at the lowest dose when preload volume did play a role in intake regulation. These findings indicate that "fullness" and pharmacological cues differentially impact the appetitive and consummatory behaviors reinforced by ethanol solutions, with intake being more sensitive to preload volume and seeking being more sensitive to preload pharmacology.
authors.affiliation: Center for Alcohol and Addiction Studies, Department of Psychiatry and Human Behavior, Brown University, Box G-BH, Providence, RI 02912, USA. Cristine_Czachowski@brown.edu
authors.forename: Cristine L
authors.initials: CL
authors.lastname: Czachowski
authors.forename: Sarah
authors.initials: S
authors.lastname: Prutzman
authors.forename: Michael J
authors.initials: MJ
authors.lastname: DeLory
mesh_terms: D000428:Alcohol Drinking; D000818:Animals; D016739:Behavior, Addictive; D001522:Behavior, Animal / Q000187:drug effects*; D002492:Central Nervous System Depressants / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D003216:Conditioning, Operant / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D005108:Extinction, Psychological / Q000187:drug effects; D008297:Male; D051381:Rats; D020318:Rats, Long-Evans; D012646:Self Administration
chemical_list: D002492:Central Nervous System Depressants; D000431:Ethanol