title: Stable hairpins having a loop consisting of 3'-deoxy-4'-C-(2-hydroxyethyl)thymidines.
abstract: A novel sugar-modified thymidine analogue, 3'-deoxy-4'-C-(2-hydroxyethyl)thymidine (X), was designed and synthesized to show that it can stabilize hairpin structures when it is present in the loop moiety, probably due to the flexibility of the one-carbon-elongated 4'-branched structure.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Shuto
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Tamura
authors.forename: Yuji
authors.initials: Y
authors.lastname: Yamamoto
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Kodama
authors.forename: Shuichi
authors.initials: S
authors.lastname: Hoshika
authors.forename: Satoshi
authors.initials: S
authors.lastname: Ichikawa
authors.forename: Yoshihito
authors.initials: Y
authors.lastname: Ueno
authors.forename: Eiko
authors.initials: E
authors.lastname: Ohtsuka
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Komatsu
authors.forename: Akira
authors.initials: A
authors.lastname: Matsuda
mesh_terms: D002942:Circular Dichroism; D019295:Computational Biology; D004720:Endonucleases / Q000378:metabolism; D009690:Nucleic Acid Conformation; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis / Q000378:metabolism; D013816:Thermodynamics; D013936:Thymidine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry*; D044366:Transition Temperature
chemical_list: C521145:3'-deoxy-4'-C-(2-hydroxyethyl)thymidine; D009838:Oligodeoxyribonucleotides; D004720:Endonucleases; D013936:Thymidine