title: The Serratia-type hemolysin of Chromobacterium violaceum.
abstract: Chromobacterium violaceum is a Gram-negative opportunistic human pathogen and an inhabitant of tropical soils and waterways. Although known primarily for the synthesis of the pigment violacein, and more recently as a reporter strain for quorum sensing, clinical reports of chromobacteriosis comprise the largest block of published literature on this organism. Genome sequencing has revealed many potential virulence factors in this microorganism, and this paper establishes the presence in C. violaceum of a Serratia type-hemolysin (ChlA) and transporter (ChlB). We also show that the hemolysin operon includes a third gene (chlC) that is predicted to encode a phosphorylation domain similar to the receiver domain of response regulators in bacterial signal transduction systems.
authors.affiliation: Department of Biology, Colorado College, Colorado Springs, CO 80903, USA.
authors.forename: Kevin C
authors.initials: KC
authors.lastname: Brumbach
authors.forename: Bryan D
authors.initials: BD
authors.lastname: Eason
authors.forename: Lamont K
authors.initials: LK
authors.lastname: Anderson
mesh_terms: D000818:Animals; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism; D002861:Chromobacterium / Q000235:genetics* / Q000502:physiology; D004912:Erythrocytes / Q000382:microbiology; D004926:Escherichia coli / Q000235:genetics; D006460:Hemolysin Proteins / Q000235:genetics* / Q000378:metabolism; D006461:Hemolysis / Q000235:genetics / Q000502:physiology; D009876:Operon; D030781:Organisms, Genetically Modified / Q000378:metabolism; D010641:Phenotype; D021381:Protein Transport / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012756:Sheep / Q000382:microbiology
chemical_list: D002352:Carrier Proteins; D006460:Hemolysin Proteins