Autoantibodies to the inhibitor of apoptosis protein survivin in patients with brain tumors.
Survivin is a member of the inhibitor of apoptosis protein (IAP) family and is frequently expressed in cancers, including meningiomas and gliomas. Survivin may be associated with tumor progression and poor prognosis of patients with brain tumors. Using ELISA and immunoblot analysis we asked whether survivin is capable of eliciting a humoral immune response in patients with meningiomas and gliomas. Survivin-specific antibodies were detected in 5 of 42 (11.9%) patients with meningiomas and 3 of 35 (8.6%) patients with malignant gliomas of the WHO grades 3 and 4, but not in healthy controls. Tumors of patients with detectable anti-survivin antibodies demonstrated survivin expression in at least 20% of the tumor cells as assessed by immunohistochemistry. We conclude that patients with meningiomas and malignant gliomas can mount a high-titer IgG immune response against the 'universal' tumor-associated antigen survivin. Anti-survivin antibodies may represent attractive tools for diagnosis and follow-up of brain tumors.
Söling
Ariane
A
Molecular Neurooncology Laboratory, Department of Neurosurgery, Martin Luther University Halle-Wittenberg, D-06097 Halle, Germany. ariane.soeling@medizin.uni-halle.de
Plugge
Eva-Maria
EM
Schmitz
Marc
M
Weigle
Bernd
B
Jacob
Roland
R
Illert
Jörg
J
Holzhausen
Hans-Jürgen
HJ
Rainov
Nikolai G
NG
D000328:Adult; D000368:Aged; D017209:Apoptosis / Q000276:immunology; D001323:Autoantibodies / Q000097:blood*; D001932:Brain Neoplasms / Q000276:immunology* / Q000473:pathology; D005910:Glioma / Q000276:immunology / Q000473:pathology; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D051034:Inhibitor of Apoptosis Proteins; D008579:Meningioma / Q000276:immunology / Q000473:pathology; D008869:Microtubule-Associated Proteins / Q000235:genetics / Q000276:immunology*; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000235:genetics / Q000276:immunology*; D009367:Neoplasm Staging; D011994:Recombinant Proteins / Q000276:immunology; D012016:Reference Values; D000077022:Survivin
D001323:Autoantibodies; C107489:BIRC5 protein, human; D007074:Immunoglobulin G; D051034:Inhibitor of Apoptosis Proteins; D008869:Microtubule-Associated Proteins; D009363:Neoplasm Proteins; D011994:Recombinant Proteins; D000077022:Survivin