Synthesis and properties of G-quartet oligonucleotide-HIV-1 tat peptide conjugate.
Zintevir is a single strand DNA that forms an intramolecular quadruplex structure and shows potent anti-human immunodeficiency virus type 1 (HIV-1) activity. Zintevir was discovered as a potent inhibitor for HIV-1 integrase. Recently, the primary molecular target of Zintevir, however, was shown to be the HIV-1 gp120. In fact, in our previous study, Zintevir was shown to inhibit the only processes of the viral adsorption and the entry into the cell. This result suggests that Zintevir is not able to penetrate through the cell membranes. Therefore, we designed and synthesized the complex of D-17mer with HIV-1 tat peptide that has the cell membrane permeability.
Kumashiro
Tetsuya
T
Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan.
Otake
Toru
T
Kawahata
Takuya
T
Akagi
Masao
M
Urata
Hidehito
H
D019380:Anti-HIV Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D002463:Cell Membrane Permeability; D004247:DNA / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D054856:G-Quadruplexes; D009841:Oligonucleotides / Q000737:chemistry
D019380:Anti-HIV Agents; D009841:Oligonucleotides; D004247:DNA; C098172:T 30177