title: Synthesis, SAR and antibacterial studies on novel chalcone oxazolidinone hybrids.
abstract: With an intention to synergise the antibacterial activity of chalcones and oxazolidinones, several hybrid compounds possessing both chalcone and oxazolidinone moieties were synthesized and tested for antibacterial activity. The hybrid molecules containing heterocycles instead of aromatic ring were found to be active. A SAR study with various heterocycles resulted in a lead molecule 20, which was converted to one of the potent antibacterial compounds 27.
authors.affiliation: Anti-infectives Discovery Group, Discovery Research, Dr. Reddy's Laboratories Ltd., Miyapur, Hyderabad 500 049, India. selvakumarn@drreddys.com
authors.forename: N
authors.initials: N
authors.lastname: Selvakumar
authors.forename: G Sunil
authors.initials: GS
authors.lastname: Kumar
authors.forename: A Malar
authors.initials: AM
authors.lastname: Azhagan
authors.forename: G Govinda
authors.initials: GG
authors.lastname: Rajulu
authors.forename: Shikha
authors.initials: S
authors.lastname: Sharma
authors.forename: M Sitaram
authors.initials: MS
authors.lastname: Kumar
authors.forename: Jagattaran
authors.initials: J
authors.lastname: Das
authors.forename: Javed
authors.initials: J
authors.lastname: Iqbal
authors.forename: Sanjay
authors.initials: S
authors.lastname: Trehan
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D047188:Chalcones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D023303:Oxazolidinones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D013859:Thiocarbamates / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D047188:Chalcones; D023303:Oxazolidinones; D013859:Thiocarbamates