title: Effect of dark chocolate on arterial function in healthy individuals: cocoa instead of ambrosia?
abstract: Cocoa has been consumed for at least 2500 years, and for long time it has been regarded as a medicine. Arterial function is of paramount importance for the proper function and integrity of the cardiovascular system. Dark chocolate and flavonoid-rich cocoa have beneficial acute and short-term effects on endothelial function and wave reflections in normal individuals, in adults with cardiovascular risk factors, and in patients with coronary artery disease. Furthermore, dark chocolate and flavonoid-rich cocoa may have a blood pressure-lowering effect. These effects can be attributed to flavonoids and are mainly mediated through increased nitric oxide bioavailability. Further research is needed to demonstrate whether these effects of chocolate on arterial function are translated into clinical benefit.
authors.affiliation: Hypertension Unit and Peripheral Vessels Unit, 1st Cardiology Department, Athens Medical School, Hippokration Hospital 17, Kerassoundos Str., Athens 11528, Greece. cvlachop@otenet.gr
authors.forename: Charalambos
authors.initials: C
authors.lastname: Vlachopoulos
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Alexopoulos
authors.forename: Christodoulos
authors.initials: C
authors.lastname: Stefanadis
mesh_terms: D031164:Ambrosia; D001158:Arteries / Q000187:drug effects* / Q000502:physiology; D001794:Blood Pressure / Q000187:drug effects; D002099:Cacao; D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000378:metabolism / Q000503:physiopathology / Q000517:prevention & control; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000503:physiopathology; D005419:Flavonoids / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D009569:Nitric Oxide / Q000378:metabolism; D012307:Risk Factors; D014655:Vascular Resistance / Q000187:drug effects
chemical_list: D005419:Flavonoids; D009569:Nitric Oxide