title: Cadherin expression in ovarian carcinoma and malignant mesothelioma cell effusions.
abstract: OBJECTIVE
  To analyze potential differences in cadherin expression between ovarian carcinoma/primary peritoneal carcinoma (OC/PPC) and malignant mesothelioma (MM) at this anatomic site.
  
  
  METHODS
  MM (N=24) and OC/PPC (N= 53) effusions were analyzed for E-cadherin, N-cadherin and P-cadherin protein expression using immunocytochemistry.
  
  
  RESULTS
  Both MM and OC/PPC cells showed frequent expression of all 3 cadherins. OC/PPC specimens expressed E-cadherin and N-cadherin in 52 of 53 cases and P-cadherin in 51 of 53 cases. MM effusions expressed E-cadherin, N-cadherin and P-cadherin in 22 of 24, 21 of24 and 23 of24 cases, respectively. The differences in the percentage of cadherin-positive cells was weakly significant for P-cadherin (higher expression in MM, p = 0.04), but E-cadherin and N-cadherin expression was comparable (p > 0.05).
  
  
  CONCLUSIONS
  MM and OC/PPC coexpress different cadherin family members. P-cadherin, E-cadherin and N-cadherin are not useful for differentiation between OC/PPC and MM in effusions.
authors.affiliation: Department of Pathology, National Hospital-Norwegian Radium Hospital, University of Oslo, Oslo, Norway.
authors.forename: Stine
authors.initials: S
authors.lastname: Sivertsen
authors.forename: Aasmund
authors.initials: A
authors.lastname: Berner
authors.forename: Claire W
authors.initials: CW
authors.lastname: Michael
authors.forename: Carlos
authors.initials: C
authors.lastname: Bedrossian
authors.forename: Ben
authors.initials: B
authors.lastname: Davidson
mesh_terms: D001202:Ascitic Fluid / Q000378:metabolism* / Q000473:pathology; D014408:Biomarkers, Tumor / Q000378:metabolism; D015820:Cadherins / Q000378:metabolism*; D002277:Carcinoma / Q000378:metabolism* / Q000473:pathology; D002452:Cell Count; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008654:Mesothelioma / Q000378:metabolism* / Q000473:pathology; D010051:Ovarian Neoplasms / Q000378:metabolism* / Q000473:pathology; D015854:Up-Regulation
chemical_list: D014408:Biomarkers, Tumor; D015820:Cadherins