High seroprevalence of Epstein-Barr virus in children with multiple sclerosis.
We studied seroprevalence and concentrations of Epstein-Barr virus (EBV) antibodies in 147 pediatric patients with multiple sclerosis (MS) and paired controls. The children with MS showed a near-complete seropositivity for EBV antibody against virus capsid antigen (98.6% vs 72.1% in controls, p = 0.001) but did not display serologic evidence for a recent EBV infection. EBV antibody concentrations of pediatric patients with MS were significantly higher vs controls.
Pohl
D
D
Brauweg 19, 37073 Goettingen, Germany. dani.pohl@gmx.net
Krone
B
B
Rostasy
K
K
Kahler
E
E
Brunner
E
E
Lehnert
M
M
Wagner
H-J
HJ
Gärtner
J
J
Hanefeld
F
F
D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000097:blood; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D020031:Epstein-Barr Virus Infections / Q000453:epidemiology / Q000821:virology; D005260:Female; D005858:Germany / Q000453:epidemiology; D004854:Herpesvirus 4, Human / Q000302:isolation & purification* / Q000378:metabolism; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D009103:Multiple Sclerosis / Q000453:epidemiology / Q000821:virology*; D016036:Seroepidemiologic Studies
D000914:Antibodies, Viral