title: [Phagocytes rate and cellular viability of the monocytes in patients with hepatosplenic schistosomiasis mansoni who underwent splenectomy and auto-implantation of spleen tissue].
abstract: Mansonic schistosomiasis remains a medical-social issue in Northeastern Brazil. In children, surgical treatment includes splenectomy and spleen autoimplantation. This procedure reduces post-splenectomy sepsis. The aim of this study was to analyze the phagocyte rate and the cellular viability of monocytes in patients with hepatosplenic schistosomiasis, who underwent splenectomy and spleen autoimplantation from 1991 to 2001. Of the 22 individuals analyzed, 11 were patients who underwent splenectomy and spleen autoimplantation (Study group) and 11 were healthy individuals from the same region (Control group). Both groups presented similar mean age. No difference was found in the phagocyte rate between the control group (36.1%+/-4.9%) and study group (33.5%+/-5.7%). However, phagocyte viability after stimulation with lipopolysaccharide was higher (94%) in control group, when compared to the study group (65%), p<0.001. It is possible to hypothesize that monocytes from the study group patients presented a reduced response to the microorganism challenge, in the face of a harmful and long-lasting stimulus.
authors.affiliation: Departamento de Cirurgia, Universidade Federal de Pernambuco, Recife, PE.
authors.forename: Carlos Teixeira
authors.initials: CT
authors.lastname: Brandt
authors.forename: Célia Maria Machado Barbosa
authors.initials: CM
authors.lastname: de Castro
authors.forename: Stella Maria Lisboa
authors.initials: SM
authors.lastname: de Lavor
authors.forename: Francisco Machado Manhães
authors.initials: FM
authors.lastname: de Castro
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D002470:Cell Survival; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008109:Liver Diseases, Parasitic / Q000276:immunology / Q000469:parasitology* / Q000601:surgery; D008297:Male; D009000:Monocytes / Q000276:immunology / Q000502:physiology*; D010587:Phagocytosis / Q000276:immunology / Q000502:physiology*; D011446:Prospective Studies; D012555:Schistosomiasis mansoni / Q000276:immunology / Q000601:surgery*; D013154:Spleen / Q000276:immunology / Q000637:transplantation*; D013156:Splenectomy; D013158:Splenic Diseases / Q000276:immunology / Q000469:parasitology* / Q000601:surgery; D014182:Transplantation, Autologous