title: Combined surgery and chemoradiation as a treatment for the Buschke-Löwenstein tumour.
abstract: BACKGROUND
  The Buschke-Löwenstein tumour (BLT) or giant condyloma acuminata is a rare disease which affects the anogenital region. Although histologically benign, it behaves in a malignant fashion, infiltrating the surrounding tissues. The morbidity and mortality from this tumour is high, as is the risk of recurrence following treatment. It lies on the continuum between the benign condylomata acuminata and squamous cell carcinoma. The human papillomavirus is implicated in its aetiology. Treatment is controversial, with topical chemotherapy, radiotherapy, immunotherapy and radical surgery all having been employed. Chemoradiation remains the mainstay of treatment for anal cancers but has not been routinely employed in the management of the BLT without squamous cell carcinoma transformation.
  
  
  METHODS
  Two cases of extensive perineal BLT treated with chemoradiation and subsequent surgical excision are presented.
  
  
  RESULTS
  The first patient had a good symptomatic response to the chemoradiation but unfortunately died of recurrent disease following surgery. The second patient had a macroscopically complete response to chemoradiation and remains well following abdominoperineal excision.
  
  
  CONCLUSIONS
  Pre-operative chemoradiation has proved to be useful in management for histologically proven benign BLT
authors.affiliation: Department of Surgery, Wexham Park Hospital, Slough, Berkshire, SL2 4HL, UK. matthew@tytherleigh3.fsnet.co.uk
authors.forename: M G
authors.initials: MG
authors.lastname: Tytherleigh
authors.forename: A J
authors.initials: AJ
authors.lastname: Birtle
authors.forename: C E
authors.initials: CE
authors.lastname: Cohen
authors.forename: R
authors.initials: R
authors.lastname: Glynne-Jones
authors.forename: J
authors.initials: J
authors.lastname: Livingstone
authors.forename: J
authors.initials: J
authors.lastname: Gilbert
mesh_terms: D000008:Abdominal Neoplasms / Q000556:secondary / Q000628:therapy; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001005:Anus Neoplasms / Q000556:secondary / Q000628:therapy; D002278:Carcinoma in Situ / Q000473:pathology / Q000628:therapy; D002294:Carcinoma, Squamous Cell / Q000628:therapy; D017024:Chemotherapy, Adjuvant; D002945:Cisplatin / Q000008:administration & dosage; D003218:Condylomata Acuminata / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D017809:Fatal Outcome; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D009364:Neoplasm Recurrence, Local; D010502:Perineum / Q000473:pathology* / Q000601:surgery*; D018714:Radiotherapy, Adjuvant; D012004:Rectal Neoplasms / Q000556:secondary / Q000628:therapy; D012983:Soft Tissue Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*
chemical_list: D002945:Cisplatin; D005472:Fluorouracil