Unusual beta-elimination of carbocyclic ketonucleosides catalyzed by silica gel.
Beta-elimination reactions occurred when carbocyclic ketonucleosides were treated with silica gel and alpha,beta-unsaturated ketonucleosides were obtained. The positions of ketone groups did not affect the occurrance of the elimination reaction. The yields of the reaction were influenced by the properties of leaving groups.
Liu
Xiaozhen
X
Beijing Institute of Pharmaceutical Chemistry, Beijing, China.
Guo
Xin
X
Wang
Fei
F
Lei
Guangqing
G
Luo
Dongdong
D
D000998:Antiviral Agents / Q000138:chemical synthesis*; D002384:Catalysis; D007659:Ketones / Q000138:chemical synthesis*; D009705:Nucleosides / Q000138:chemical synthesis*; D058428:Silica Gel; D012822:Silicon Dioxide / Q000737:chemistry*
D000998:Antiviral Agents; D007659:Ketones; D009705:Nucleosides; D058428:Silica Gel; D012822:Silicon Dioxide