title: Distinct chromosomal profiles in metastasizing and non-metastasizing colorectal carcinomas.
abstract: BACKGROUND
  The prognosis of colorectal cancer patients is to a considerable extent determined by the metastatic potency of the primary tumor. However, despite the fact that liver metastases are the leading cause of death for cancer patients, the molecular basis still remains poorly understood and independent prognostic markers have not been established.
  
  
  METHODS
  Comparative genomic hybridization (CGH) was used to screen colorectal carcinomas without distant metastases (n=18) and carcinomas synchronously metastatic to the liver (n=18). We aimed to detect distinct chromosomal aberrations indicating a metastatic phenotype.
  
  
  CONCLUSIONS
  Metastatic tumors exhibited a significantly (P=0.03) higher ANCA value (13.8) if compared with non-metastatic cancers (10.0). Furthermore, we observed that losses of chromosomal regions 1p32-ter and 9q33-ter were present at much higher frequencies in metastatic than in non-metastatic cancers, respectively (P=0.02 and 0.04).
  
  
  CONCLUSIONS
  These data indicate that metastatic tumors may be separated from non-metastatic colorectal cancers based on their genomic profile.
authors.affiliation: Department of General Surgery, University Medical Center, Göttingen, Germany. mghadim@uni-goettingen.de
authors.forename: B Michael
authors.initials: BM
authors.lastname: Ghadimi
authors.forename: Marian
authors.initials: M
authors.lastname: Grade
authors.forename: Carsten
authors.initials: C
authors.lastname: Mönkemeyer
authors.forename: Bettina
authors.initials: B
authors.lastname: Kulle
authors.forename: Jochen
authors.initials: J
authors.lastname: Gaedcke
authors.forename: Bastian
authors.initials: B
authors.lastname: Gunawan
authors.forename: Claus
authors.initials: C
authors.lastname: Langer
authors.forename: Torsten
authors.initials: T
authors.lastname: Liersch
authors.forename: Heinz
authors.initials: H
authors.lastname: Becker
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002872:Chromosome Deletion; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics*; D002899:Chromosomes, Human, Pair 9 / Q000235:genetics*; D015179:Colorectal Neoplasms / Q000235:genetics* / Q000473:pathology*; D005260:Female; D006801:Humans; D007621:Karyotyping; D008113:Liver Neoplasms / Q000235:genetics* / Q000556:secondary*; D008297:Male; D008875:Middle Aged