A case of HHV-6 associated acute necrotizing encephalopathy with increase of CD56bright NKcells.
We describe a 15-month-old girl with acute necrotizing encephalopathy (ANE) associated with HHV-6. Inflammatory cytokines were elevated in the CSF and serum and the number of CD56bright NK cells was significantly increased in the peripheral blood. CD56bright NK cells may be involved in the pathogenesis of ANE by producing inflammatory cytokines.
Kubo
Tomohiro
T
Department of Pediatrics, National Defense Medical College, Saitama, Japan. bokukubo17@hotmail.com
Sato
Kengo
K
Kobayashi
Daisuke
D
Motegi
Akira
A
Kobayashi
Osamu
O
Takeshita
Seiichirou
S
Nonoyama
Shigeaki
S
D001927:Brain Diseases / Q000150:complications / Q000276:immunology / Q000821:virology*; D019002:CD56 Antigen / Q000276:immunology; D016207:Cytokines / Q000097:blood / Q000134:cerebrospinal fluid; D005260:Female; D015654:Herpesvirus 6, Human / Q000276:immunology / Q000472:pathogenicity*; D006801:Humans; D007074:Immunoglobulin G / Q000134:cerebrospinal fluid; D007223:Infant; D007694:Killer Cells, Natural / Q000276:immunology; D009336:Necrosis / Q000821:virology; D019349:Roseolovirus Infections / Q000150:complications / Q000276:immunology / Q000821:virology*
D019002:CD56 Antigen; D016207:Cytokines; D007074:Immunoglobulin G