title: The recognition of Z-DNA by chiral helicene.
abstract: Enantiomeric helicenes of (P)-A and (M)-A were synthesized. The binding of the helicenes to B- and Z-DNA was studied quantitatively by CD, equilibrium dialysis, and fluorescence spectroscopy. Enantiomeric (P)-A not only bound selectively to Z-DNA, but also effectively converted the B-DNA conformation to Z-DNA. The enantio-selectivity of the helicenes offers a new route for the rational design of inhibitors of biological functions that may depend on Z-DNA.
authors.affiliation: Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo, Kyoto 606-8501, Japan.
authors.forename: Yan
authors.initials: Y
authors.lastname: Xu
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Sugiyama
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Tanaka
authors.forename: Hideji
authors.initials: H
authors.lastname: Osuga
mesh_terms: D002942:Circular Dichroism; D043542:DNA, Z-Form / Q000737:chemistry*; D007700:Kinetics; D008958:Models, Molecular; D011083:Polycyclic Compounds / Q000737:chemistry*; D013816:Thermodynamics
chemical_list: D043542:DNA, Z-Form; D011083:Polycyclic Compounds; C031660:helicenes