title: No improvement of posttraumatic stress disorder symptoms with guanfacine treatment.
abstract: OBJECTIVE
  The authors report an 8-week, double-blind, randomized controlled trial of guanfacine versus placebo for posttraumatic stress disorder (PTSD).
  
  
  METHODS
  Veterans with chronic PTSD who were medication-free or receiving stable pharmacotherapy were randomly assigned to guanfacine (N=29) versus placebo (N=34).
  
  
  RESULTS
  Guanfacine had no effect on PTSD symptoms, subjective sleep quality, or general mood disturbances. Guanfacine was associated with a number of side effects.
  
  
  CONCLUSIONS
  These results do not support the use of alpha 2 agonists in veterans with chronic PTSD.
authors.affiliation: Department of Psychiatry, University of California, San Francisco, USA. neylan@itsa.ucsf.edu
authors.forename: Thomas C
authors.initials: TC
authors.lastname: Neylan
authors.forename: Maryann
authors.initials: M
authors.lastname: Lenoci
authors.forename: Kristin W
authors.initials: KW
authors.lastname: Samuelson
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Metzler
authors.forename: Clare
authors.initials: C
authors.lastname: Henn-Haase
authors.forename: Robert W
authors.initials: RW
authors.lastname: Hierholzer
authors.forename: Steven E
authors.initials: SE
authors.lastname: Lindley
authors.forename: Christian
authors.initials: C
authors.lastname: Otte
authors.forename: Frank B
authors.initials: FB
authors.lastname: Schoenfeld
authors.forename: Jerome A
authors.initials: JA
authors.lastname: Yesavage
authors.forename: Charles R
authors.initials: CR
authors.lastname: Marmar
mesh_terms: D000316:Adrenergic alpha-Agonists / Q000009:adverse effects / Q000627:therapeutic use*; D002908:Chronic Disease; D015897:Comorbidity; D004311:Double-Blind Method; D016316:Guanfacine / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D019964:Mood Disorders / Q000188:drug therapy / Q000453:epidemiology / Q000523:psychology; D010919:Placebos; D012890:Sleep / Q000187:drug effects; D013313:Stress Disorders, Post-Traumatic / Q000188:drug therapy* / Q000453:epidemiology / Q000523:psychology; D016896:Treatment Outcome; D014728:Veterans / Q000523:psychology
chemical_list: D000316:Adrenergic alpha-Agonists; D010919:Placebos; D016316:Guanfacine