Total synthesis of bioactive peptides and depsipeptides from marine opisthobranch molluscs.
This chapter covers the synthetic aspects of both linear or cyclic peptides and depsipeptides isolated from opisthobranch molluscs. In many cases, synthetic effort not only determined the absolute stereostructure of these compounds but also made it possible to supply sufficient amounts for the evaluation of pharmacological activities. A summary of the synthetic work associated with each compound is reported after a short description of its natural source and biological properties. Discussion in the text concentrates on key reactions and synthetic efficiency.
Della Monica
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Dipartimento di Chimica, Università di Salerno, Via S. Allende, 84081 Baronissi (Salerno), Italy.
Della Sala
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De Riccardis
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F
Izzo
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Spinella
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A
D000818:Animals; D001685:Biological Factors / Q000138:chemical synthesis / Q000737:chemistry*; D001688:Biological Products / Q000138:chemical synthesis*; D047630:Depsipeptides / Q000138:chemical synthesis / Q000737:chemistry*; D008386:Marine Biology; D008974:Mollusca / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry*
D001685:Biological Factors; D001688:Biological Products; D047630:Depsipeptides; D010455:Peptides