title: Autologous endothelial progenitor cells transplantation for the therapy of primary pulmonary hypertension.
abstract: Primary pulmonary hypertension (PPH) is a fatal cardiovascular disease characterized by increased pulmonary vascular resistance and progressive right heart failure. It is associated with a very high morbidity and mortality rate. The therapeutic effects of current pharmacological management of PPH are limited. Recent studies have demonstrated that endothelial dysfunction and cell loss play a critical role in the pathogenesis of PPH. Emerging evidence also shows that circulating endothelial progenitor cells instigate new vessel formation via vasculogenesis and revascularization, and provide ongoing endothelial repair by homing to site of endothelial damage. We hypothesized that autologous endothelial progenitor cells transplantation may be a feasible adjunctive therapeutic option for PPH.
authors.affiliation: Department of Cardiology, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, PR China.
authors.forename: Chunlai
authors.initials: C
authors.lastname: Zeng
authors.forename: Xinxiang
authors.initials: X
authors.lastname: Wang
authors.forename: Xiaosheng
authors.initials: X
authors.lastname: Hu
authors.forename: Junzhu
authors.initials: J
authors.lastname: Chen
authors.forename: Lexin
authors.initials: L
authors.lastname: Wang
mesh_terms: D004730:Endothelium, Vascular / Q000166:cytology*; D006801:Humans; D006976:Hypertension, Pulmonary / Q000503:physiopathology / Q000628:therapy*; D008954:Models, Biological; D033581:Stem Cell Transplantation / Q000379:methods*; D013234:Stem Cells / Q000166:cytology*; D014184:Transplantation, Homologous