title: Antioxidant activity of supramolecular water-soluble fullerenes evaluated by beta-carotene bleaching assay.
abstract: We investigated the antioxidant activity of supramolecular water-soluble fullerenes, polyvinylpyrrolidone (PVP)-entrapped C(60), and gamma-cyclodextrin (CD)-bi-capped C(60), based on comparable beta-carotene bleaching assay. Antioxidant activity against reactive oxygen species (ROS) generated by three different methods, (i) autoxidation of linoleic acid, (ii) hydrogen peroxide promoter, and (iii) photoirradiation, was evaluated as percent of inhibition relative to a control experiment in view of the bleaching rate constant (k(obs)) as well as the persistent absorbency of beta-carotene. Water-soluble fullerenes exhibit significant inhibitory effects on the oxidative discoloration of beta-carotene in any system.
authors.affiliation: Vitamin C60 BioResearch Corporation, Tokyo, Japan. info@vc60.com
authors.forename: Hiroya
authors.initials: H
authors.lastname: Takada
authors.forename: Ken
authors.initials: K
authors.lastname: Kokubo
authors.forename: Kenji
authors.initials: K
authors.lastname: Matsubayashi
authors.forename: Takumi
authors.initials: T
authors.lastname: Oshima
mesh_terms: D000975:Antioxidants / Q000494:pharmacology*; D037741:Fullerenes / Q000737:chemistry*; D012995:Solubility; D014867:Water; D019207:beta Carotene / Q000737:chemistry*
chemical_list: D000975:Antioxidants; D037741:Fullerenes; D019207:beta Carotene; D014867:Water