Novel drug releasing system triggered by hybridization with target sequence.
We have already established the strategy of synchronous activation by hybridization, in which the highly reactive cross-linking agent, 2-amino-6-vinylpurine nucleoside analog can be generated from its stable precursors, the phenylsulfide derivatives, by a hybridization-promoted activation process with selectivity to cytosine. In this study, this in situ activation system was applied to method for the drug releasing system triggered by hybridization with the target sequence.
Nakayama
Shizuka
S
Institute of Multidisciplinary Research for Advanced Materials Tohoku University, Katahira 2-1-1, Aoba-ku, Sendai-Shi, Miyagi, Japan.
Nagatsugi
Fumi
F
Sasaki
Shigeki
S
D003432:Cross-Linking Reagents / Q000737:chemistry; D003596:Cytosine / Q000737:chemistry; D016503:Drug Delivery Systems / Q000379:methods*; D031541:Fluorescence Resonance Energy Transfer; D009693:Nucleic Acid Hybridization; D015345:Oligonucleotide Probes / Q000737:chemistry; D011687:Purines / Q000737:chemistry; D014753:Vinyl Compounds / Q000737:chemistry
C432203:2-amino-6-vinylpurine; D003432:Cross-Linking Reagents; D015345:Oligonucleotide Probes; D011687:Purines; D014753:Vinyl Compounds; D003596:Cytosine