title: Lipoprotein-associated phospholipase A2 concentrations in plasma are associated with the extent of coronary artery disease and correlate to adipose tissue levels of marine n-3 fatty acids.
abstract: Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) is an emerging risk factor for cardiovascular disease. In the present study, plasma levels of Lp-PLA(2) were measured in patients (n=301) admitted to elective coronary angiography because of suspected coronary artery disease (CAD). In a multiple linear regression analysis, the degree of CAD (0-, 1-, 2- or 3-vessel disease) and plasma LDL cholesterol significantly correlated to Lp-PLA(2) levels. Also the content of the marine n-3 fatty acid, eicosapentaenoic acid (EPA) in adipose tissue, a measure of long-term intake of seafood independently and inversely (r=-0.18, p<0.01) correlated with plasma levels of Lp-PLA(2). The results support the view that Lp-PLA(2) may relate to CAD and that intake of marine n-3 fatty acids might reduce plasma Lp-PLA(2) suggesting another mechanism by which n-3 fatty acids could reduce the risk of cardiovascular disease.
authors.affiliation: Department of Cardiology and Center for Cardiovascular Research, Aalborg Hospital, Århus University Hospitals, Sdr. Skovvej 15, 9100 Aalborg, Denmark. Electronic address: ebs@dadlnet.dk.
authors.forename: Erik Berg
authors.initials: EB
authors.lastname: Schmidt
authors.affiliation: Department of Internal Medicine II-Cardiology, University of Ulm Medical Center, Ulm, Germany.
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Koenig
authors.affiliation: Department of Internal Medicine II-Cardiology, University of Ulm Medical Center, Ulm, Germany.
authors.forename: Natalie
authors.initials: N
authors.lastname: Khuseyinova
authors.affiliation: Department of Nephrology, Aalborg Hospital, Århus University Hospitals, Denmark.
authors.forename: Jeppe Hagstrup
authors.initials: JH
authors.lastname: Christensen
mesh_terms: D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase / Q000097:blood*; D000273:Adipose Tissue / Q000737:chemistry*; D000368:Aged; D003324:Coronary Artery Disease / Q000097:blood / Q000503:physiopathology*; D003718:Denmark; D015525:Fatty Acids, Omega-3 / Q000032:analysis*; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D017747:Seafood
chemical_list: D015525:Fatty Acids, Omega-3; D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase