Mechanisms of long-lasting enhancement of corticostriatal neurotransmission by taurine.
The long-lasting enhancement of corticostriatal neurotransmission by taurine, LLE-TAU represents a complex phenomenon requiring concurrent activation of glycine, DA and Ach receptors as well as taurine uptake. The data on the mechanisms of corticostriatal LLE-TAU can be integrated in the following scheme. Taurine interaction with glycine and GABAA receptors causes depolarization of striatal medium spiny cells (Chepkova et al., 2002) which is enhanced by taurine electrogenic uptake by TauT (Sarkar et al., 2003). This depolarization leads to Ca2+ entry via low voltage gated Ca2+ channels. Muscarinic M1 receptors are expressed in medium spiny neurons (Yan et al., 2001) and regulate their excitability mostly via phospholipase C (PLC)/PKC cascade (Lin et al., 2004). Concurrent activation of M1 and PLC-coupled D1 receptors (O'Sullivan et al., 2004) can amplify Ca2+ signal via IP3- stimulated Ca2+ release from intracellular stores and stimulate PKC.
Chepkova
Aisa N
AN
Institute of Neurophysiology, Heinrich Heine University, Düsseldorf, D-40001, Germany (POB 101007). aiso_chepkova@yahoo.com
Sergeeva
Olga A
OA
Haas
Helmut L
HL
D000109:Acetylcholine / Q000378:metabolism; D000818:Animals; D002118:Calcium / Q000378:metabolism; D015220:Calcium Channels / Q000378:metabolism; D002540:Cerebral Cortex / Q000378:metabolism*; D003342:Corpus Striatum / Q000378:metabolism*; D017868:Cyclic AMP-Dependent Protein Kinases / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism; D004789:Enzyme Activation; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D011493:Protein Kinase C / Q000378:metabolism; D018009:Receptors, Glycine / Q000378:metabolism; D009435:Synaptic Transmission / Q000502:physiology*; D013654:Taurine / Q000378:metabolism*
D015220:Calcium Channels; D018009:Receptors, Glycine; D013654:Taurine; D017868:Cyclic AMP-Dependent Protein Kinases; D011493:Protein Kinase C; D000109:Acetylcholine; D002118:Calcium; D004298:Dopamine