Carbohydrate antigen 125: an emerging prognostic risk factor in acute heart failure?
OBJECTIVE
To assess whether circulating levels of carbohydrate antigen 125 (CA125) predict subsequent 6-month all-cause mortality in patients after the index hospitalisation for acute heart failure (HF).


METHODS
Prospective cohort study at a single teaching centre in Spain.


METHODS
529 consecutive patients with acute HF admitted in a single university centre were analysed. In addition to the traditional clinical information, CA125 (U/ml) was measured during the early course of hospitalisation. The independent association between baseline CA125 and mortality was assessed with Cox regression analysis. The follow-up was limited to 6 months.


RESULTS
349 (66%) patients showed serum levels of CA125 >35 U/ml (established cut-off point value). At a 6-month follow-up, 89 (16.8%) deaths were identified. A positive trend between mortality and CA125 quartiles was observed; 3.8%, 15.2%, 22% and 26.5% of deaths occurred from quartile 1 to 4 of CA125 (p<0.001). Likewise, a monotonic, ascending trend in the risk ratios was estimated from the multivariable Cox model. Compared with the first quartile of CA125, the HRs (95% CI) for the second, third and fourth quartiles were 3.25 (1.20 to 8.79), 4.91 (1.88 to 12.85) and 8.41 (3.24 to 21.79), respectively.


CONCLUSIONS
Serum levels of CA125 obtained in patients admitted with a diagnosis of acute HF was shown to be an independent predictor of mortality up to the 6-month follow-up.
Núñez
Julio
J
Servicio de Cardiología, Hospital Clínico Universitario, Universitat de Valencia, Valencia, Spain. yulnunez@gmail.com
Núñez
Eduardo
E
Consuegra
Luciano
L
Sanchis
Juan
J
Bodí
Vicent
V
Martínez-Brotons
Angel
A
Bertomeu-González
Vicente
V
Robles
Rocio
R
Bosch
Maria J
MJ
Fácila
Lorenzo
L
Darmofal
Helene
H
Llàcer
Angel
A
D000208:Acute Disease; D000368:Aged; D015415:Biomarkers / Q000097:blood; D018394:CA-125 Antigen / Q000097:blood*; D002303:Cardiac Output, Low / Q000401:mortality*; D016022:Case-Control Studies; D015331:Cohort Studies; D005260:Female; D006333:Heart Failure / Q000097:blood* / Q000401:mortality; D006760:Hospitalization; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D016016:Proportional Hazards Models; D012307:Risk Factors
D015415:Biomarkers; D018394:CA-125 Antigen