Exploring cocrystal-cocrystal reactivity via liquid-assisted grinding: the assembling of racemic and dismantling of enantiomeric cocrystals.
The reaction between pairs of enantiomeric cocrystals involving caffeine or theophylline and a chiral cocrystal former has been investigated by liquid-assisted grinding: we demonstrate two different outcomes for such cocrystal-cocrystal reactions.
Friscić
Tomislav
T
Pfizer Institute for Pharmaceutical Materials Science, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK.
Fábián
László
L
Burley
Jonathan C
JC
Jones
William
W
Motherwell
W D Samuel
WD
D002110:Caffeine / Q000737:chemistry*; D003460:Crystallization / Q000379:methods; D018360:Crystallography, X-Ray; D006860:Hydrogen Bonding; D008697:Methane / Q000031:analogs & derivatives / Q000737:chemistry; D008958:Models, Molecular; D015394:Molecular Structure; D009595:Nitroparaffins / Q000737:chemistry; D013237:Stereoisomerism; D013644:Tartrates / Q000737:chemistry*; D013806:Theophylline / Q000737:chemistry*
D009595:Nitroparaffins; D013644:Tartrates; D002110:Caffeine; D013806:Theophylline; D008697:Methane; C008640:nitromethane; C029768:tartaric acid