title: Low-resolution electromagnetic brain tomography (LORETA) of monozygotic twins discordant for chronic fatigue syndrome.
abstract: BACKGROUND
  Previous work using quantified EEG has suggested that brain activity in individuals with chronic fatigue syndrome (CFS) and normal persons differs. Our objective was to investigate if specific frequency band-pass regions and spatial locations are associated with CFS using low-resolution electromagnetic brain tomography (LORETA).
  
  
  METHODS
  We conducted a co-twin control study of 17 pairs of monozygotic twins where 1 twin met criteria for CFS and the co-twin was healthy. Twins underwent an extensive battery of tests including a structured psychiatric interview and a quantified EEG. Eyes closed EEG frequency-domain analysis was computed and the entire brain volume was compared of the CFS and healthy twins using a multiple comparison procedure.
  
  
  RESULTS
  Compared with their healthy co-twins, twins with CFS differed in current source density. The CFS twins had higher delta in the left uncus and parahippocampal gyrus and higher theta in the cingulate gyrus and right superior frontal gyrus.
  
  
  CONCLUSIONS
  These findings suggest that neurophysiological activity in specific areas of the brain may differentiate individuals with CFS from those in good health. The study corroborates that slowing of the deeper structures of the limbic system is associated with affect. It also supports the neurobiological model that the right forebrain is associated with sympathetic activity and the left forebrain with the effective management of energy. These preliminary findings await replication.
authors.affiliation: Nova Tech EEG, Inc., 8503 E Keats Ave, Mesa, AZ 85208, USA. LeslieSherlin@aol.com
authors.forename: Leslie
authors.initials: L
authors.lastname: Sherlin
authors.forename: Thomas
authors.initials: T
authors.lastname: Budzynski
authors.forename: Helen
authors.initials: H
authors.lastname: Kogan Budzynski
authors.forename: Marco
authors.initials: M
authors.lastname: Congedo
authors.forename: Mary E
authors.initials: ME
authors.lastname: Fischer
authors.forename: Dedra
authors.initials: D
authors.lastname: Buchwald
mesh_terms: D001921:Brain / Q000033:anatomy & histology* / Q000000981:diagnostic imaging* / Q000473:pathology / Q000503:physiopathology; D016022:Case-Control Studies; D004569:Electroencephalography; D015673:Fatigue Syndrome, Chronic / Q000000981:diagnostic imaging* / Q000503:physiopathology; D006801:Humans; D007407:Interviews as Topic; D011795:Surveys and Questionnaires; D014057:Tomography, X-Ray Computed / Q000379:methods*; D014430:Twins, Monozygotic