Cholelithiasis and thrombosis of the central retinal vein in a renal transplant recipient treated with cyclosporin.
The use of cyclosporin has been associated with the development of cholelithiasis in transplant recipients. Cholelithiasis in turn enhances the effects of cyclosporin on increased platelet aggregation. In this report, a patient who had undergone a renal transplantation as a result of malignant hypertension, and who was on immunosuppressive therapy consisting of cyclosporin, prednisone and azathioprine, developed thrombosis of the central retinal vein 5 years following the transplantation. Seven years after the transplantation, cholelithiasis, cholecystitis, cholangitis and subsequently secondary chronic biliary sclerosis were detected. Latero-lateral anastomosis between the common bile duct and duodenum was performed during explorative laparotomy and ursodeoxycholic acid treatment was introduced. The possible inter-relationship of the cholestatis, central retinal vein thrombosis and immunosuppression are discussed.
Simic
Petra
P
Department of Medicine, Clinical Hospital Center Rebro, Zagreb, Croatia. psimic@mef.hr
Gasparovic
Vladimir
V
Skegro
Mate
M
Stern-Padovan
Ranka
R
D000328:Adult; D002756:Cholagogues and Choleretics / Q000627:therapeutic use; D002769:Cholelithiasis / Q000139:chemically induced* / Q000188:drug therapy; D016572:Cyclosporine / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000627:therapeutic use; D016030:Kidney Transplantation; D012169:Retinal Vein / Q000187:drug effects* / Q000473:pathology; D013927:Thrombosis / Q000139:chemically induced*; D013997:Time Factors; D014463:Ultrasonography / Q000379:methods; D014580:Ursodeoxycholic Acid / Q000627:therapeutic use
D002756:Cholagogues and Choleretics; D007166:Immunosuppressive Agents; D014580:Ursodeoxycholic Acid; D016572:Cyclosporine