Synthesis of tetraazacalix[2]arene[2]triazines: tuning the cavity by the substituents on the bridging nitrogen atoms.
[Structure: see text] A number of tetraazacalix[2]arene[2]triazines bearing different substituents on the bridging nitrogen atoms were synthesized efficiently using a fragment coupling strategy. The N-arylation of the parent azacalix[2]arene]2]triazine afforded tetra(arylaza)calix[2]arene[2]triazine in 91% yield. The introduction of different substituents on the bridging positions led to the regulation of the cavity of the resulting macrocyclic molecules.
Wang
Qi-Qiang
QQ
Beijing National Laboratory for Molecular Sciences, Laboratory of Chemical Biology, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, China.
Wang
De-Xian
DX
Ma
Hong-Wei
HW
Wang
Mei-Xiang
MX
D018360:Crystallography, X-Ray; D008958:Models, Molecular; D009584:Nitrogen / Q000737:chemistry*; D014227:Triazines / Q000138:chemical synthesis*
D014227:Triazines; D009584:Nitrogen