Molecular design of novel spin-labeled nucleosides directly attached base moiety.
N-tert-Butylaminoxyl nucleosides (1 and 2) were synthesized starting from 6-chloropurine derivative (3). These compounds are expected as a new tool to elucidate structure of DNA. Their properties and pH-dependent change of EPR spectra were studied.
Kaneko
Toshiyuki
T
Graduate School of Pharmaceutical Sciences, Kyushu Univerisity, Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.
Katsurabara
Toshinori
T
Matsui
Yasuhiro
Y
Aso
Mariko
M
Koga
Noboru
N
Suemune
Hiroshi
H
D004578:Electron Spin Resonance Spectroscopy; D006863:Hydrogen-Ion Concentration; D009705:Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry*; D011687:Purines / Q000737:chemistry*; D011743:Pyrimidines / Q000737:chemistry*; D013113:Spin Labels / Q000138:chemical synthesis*
D009705:Nucleosides; D011687:Purines; D011743:Pyrimidines; D013113:Spin Labels