Effect of benzylic oxygen on the cytotoxic activity for colon 26 cell line of phenolic lignans.
The cytotoxic activity for colon 26 cell line of matairesinol, oxidized matairesinol, 9,9'-epoxylignan and oxidized 9,9'-epoxylignan were examined. (-)-Matairesinol (Mat 1) showed greatest cytotoxic activity (LC(50)=9 microg/ml) of the lactone-type lignans. 7,7'-Oxomatairesinol having same steric configuration as that of (-)-matairesinol showed greater activity (LC(50)=25 microg/ml) than hydroxy or mono-oxomatairesinol. The activities of 9,9'-epoxylignan and 7,7'-oxo-9,9'-epoxylignan having same steric configurations as (-)-matairesinol were weaker than that of corresponding matairesinols. Different activity levels were observed between enantiomers.
Yamauchi
Satoshi
S
Faculty of Agriculture, Ehime University. syamauch@agr.ehime-u.ac.jp
Sugahara
Takuya
T
Nakashima
Yuki
Y
Abe
Koki
K
Hayashi
Yoshimasa
Y
Akiyama
Koichi
K
Kishida
Taro
T
Maruyama
Masafumi
M
D000818:Animals; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D017705:Lignans / Q000737:chemistry / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008807:Mice, Inbred BALB C; D015394:Molecular Structure; D010100:Oxygen / Q000378:metabolism*; D010636:Phenols / Q000494:pharmacology*; D021241:Spectrometry, Mass, Electrospray Ionization
D017705:Lignans; D010636:Phenols; D010100:Oxygen