title: Hypervirulence of a rough variant of the Mycobacterium abscessus type strain.
abstract: We isolated a rough variant of Mycobacterium abscessus CIP 104536T during experimental infection of mice. We show that this variant has lost the ability to produce glycopeptidolipids, is hyperlethal for C57BL/6 mice infected intravenously, and induces a strong tumor necrosis factor-alpha response by murine monocyte-derived macrophages.
authors.affiliation: Laboratoire de Microbiologie, Hôpital Raymond Poincaré, 104 Bd Raymond Poincaré, 92380 Garches, France.
authors.forename: E
authors.initials: E
authors.lastname: Catherinot
authors.forename: J
authors.initials: J
authors.lastname: Clarissou
authors.forename: G
authors.initials: G
authors.lastname: Etienne
authors.forename: F
authors.initials: F
authors.lastname: Ripoll
authors.forename: J-F
authors.initials: JF
authors.lastname: Emile
authors.forename: M
authors.initials: M
authors.lastname: Daffé
authors.forename: C
authors.initials: C
authors.lastname: Perronne
authors.forename: C
authors.initials: C
authors.lastname: Soudais
authors.forename: J-L
authors.initials: JL
authors.lastname: Gaillard
authors.forename: M
authors.initials: M
authors.lastname: Rottman
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D006017:Glycolipids / Q000096:biosynthesis; D006020:Glycopeptides / Q000096:biosynthesis; D008264:Macrophages / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL; D009154:Mutation; D009165:Mycobacterium Infections, Nontuberculous / Q000276:immunology / Q000382:microbiology*; D016926:Mycobacterium chelonae / Q000276:immunology / Q000472:pathogenicity* / Q000502:physiology; D016019:Survival Analysis; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis; D014774:Virulence
chemical_list: D006017:Glycolipids; D006020:Glycopeptides; D014409:Tumor Necrosis Factor-alpha