title: First attempts at prediction of DNA strand-break yields using nanodosimetric data.
abstract: We present the first results of our attempts to correlate yields of ionisation clusters in a gas model of DNA and corresponding double-strand break (DSB) yields in irradiated plasmids, using a simple statistical model of DNA lesion formation. Based on the same statistical model, we also provide a comparison of simulated nanodosimetric data for electrons and published DSB yields obtained with the PARTRAC code.
authors.affiliation: Department of Particle Physics, Weizmann Institute of Science, Rehovot, Israel. gyg2101@columbia.edu
authors.forename: G
authors.initials: G
authors.lastname: Garty
authors.forename: R
authors.initials: R
authors.lastname: Schulte
authors.forename: S
authors.initials: S
authors.lastname: Shchemelinin
authors.forename: B
authors.initials: B
authors.lastname: Grosswendt
authors.forename: C
authors.initials: C
authors.lastname: Leloup
authors.forename: G
authors.initials: G
authors.lastname: Assaf
authors.forename: A
authors.initials: A
authors.lastname: Breskin
authors.forename: R
authors.initials: R
authors.lastname: Chechik
authors.forename: V
authors.initials: V
authors.lastname: Bashkirov
mesh_terms: D000465:Algorithms; D003198:Computer Simulation; D004247:DNA / Q000737:chemistry* / Q000528:radiation effects*; D004249:DNA Damage; D016208:Databases, Factual; D004307:Dose-Response Relationship, Radiation; D008832:Microchemistry / Q000379:methods; D008956:Models, Chemical; D008957:Models, Genetic; D036103:Nanotechnology / Q000379:methods*; D010865:Pilot Projects; D011829:Radiation Dosage; D011874:Radiometry / Q000379:methods*
chemical_list: D004247:DNA