title: Myofibroblastic sarcoma of the nasal cavity and paranasal sinus: a clinicopathologic study of 6 cases and review of the literature.
abstract: OBJECTIVE
  We describe the clinicopathologic features of 6 cases of myofibroblastic sarcoma (MS) occurring in the nasal cavity and paranasal sinus.
  
  
  METHODS
  The paraffin-embedded tissues of 6 cases of MS were stained immunohistochemically and examined by electron microscopy.
  
  
  RESULTS
  Clinically, a painless enlarging mass was the most common symptom, followed by the nasal obstruction, epistaxis, copious rhinorrhea, and proptosis. Histologically, the tumors showed a diffusely infiltrative growth pattern and consisted mainly of spindle cells with abundant eosinophilic cytoplasm. The hypocellular myxoid areas and the hypercellular fibrous areas were identified. Immunohistochemically, all 6 tumors were positive for vimentin, alpha-smooth muscle actin, calponin, and fibronectin. Ultrastructural examination in 3 cases showed characteristic features of myofibroblast. Follow-up in 6 patients revealed high local recurrence rate (6 out of 6).
  
  
  CONCLUSIONS
  Myofibroblastic sarcoma of the nasal cavity and paranasal sinus exhibit diverse histologic appearances and a strong aggressive behavior.
authors.affiliation: Department of Pathology and Laboratory of Pathology, West China Hospital, Zichuan University, Chengdu City, PR China
authors.forename: Guo-Zhao
authors.initials: GZ
authors.lastname: Meng
authors.forename: Hong-Ying
authors.initials: HY
authors.lastname: Zhang
authors.forename: Hong
authors.initials: H
authors.lastname: Bu
authors.forename: Guang-Hua
authors.initials: GH
authors.lastname: Yang
authors.forename: Xian-Liang
authors.initials: XL
authors.lastname: Zhang
authors.forename: Guo
authors.initials: G
authors.lastname: Yang
mesh_terms: D000199:Actins / Q000032:analysis; D000293:Adolescent; D000328:Adult; D000368:Aged; D002135:Calcium-Binding Proteins / Q000032:analysis; D017809:Fatal Outcome; D005260:Female; D005353:Fibronectins / Q000032:analysis; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008840:Microfilament Proteins / Q000032:analysis; D008875:Middle Aged; D009217:Myosarcoma / Q000737:chemistry / Q000473:pathology* / Q000648:ultrastructure; D009361:Neoplasm Invasiveness; D009669:Nose Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000648:ultrastructure; D010255:Paranasal Sinus Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000648:ultrastructure; D014746:Vimentin / Q000032:analysis; D000096985:Calponins
chemical_list: D000199:Actins; D002135:Calcium-Binding Proteins; D005353:Fibronectins; D008840:Microfilament Proteins; D014746:Vimentin; D000096985:Calponins