[Characteristics of amaranth oil effect on the antioxidant system of the liver and blood in mice with malignant lymphoma growth].
The dynamics of functioning of the lipid peroxidation <--> antioxidant activity system was studied during the tumor growth in the blood, liver and NK/Ly cells in mice fed with amaranth oil (100 microL/100 g, once a day, 10 days before inoculation and during tumor growth for 14 days). Different effects on antioxidant activity were demonstrated. Activity of the antioxidant enzymes in hepatocytes of mice fed with amaranth oil was aimed at maintenance of antioxidant defence in tumor growth. This effect was achieved owing to the marked increase in superoxide dismutase, preserved catalase and decreased glutathione peroxidase activities with simultaneous increase in hydroperoxides levels and decrease of thiobarbituric acid-reactive subspecies. Changes observed in NK/Ly lymphoma cells were directed to providing a higher prooxidant activity than in the liver cells. Modification of antioxidant activity induced by amaranth oil can maintain oxygen homeostasis, morphofunctional state and inhibit tumor cells proliferation.
Ielisieieva
O P
OP
Kamins'kyĭ
D V
DV
Cherkas
A P
AP
Ambarova
L I
LI
Vyshemyrs'ka
L D
LD
Dzhura
O R
OR
Semen
Kh O
KhO
Makhotina
O O
OO
D000284:Administration, Oral; D027721:Amaranthus / Q000737:chemistry*; D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D002374:Catalase / Q000097:blood / Q000378:metabolism; D049109:Cell Proliferation / Q000187:drug effects; D005979:Glutathione Peroxidase / Q000097:blood / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects*; D008054:Lipid Peroxides / Q000097:blood / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000473:pathology; D008223:Lymphoma / Q000097:blood / Q000201:enzymology / Q000473:pathology / Q000517:prevention & control; D051379:Mice; D010938:Plant Oils / Q000494:pharmacology* / Q000627:therapeutic use; D013482:Superoxide Dismutase / Q000097:blood / Q000378:metabolism
D000975:Antioxidants; D008054:Lipid Peroxides; D010938:Plant Oils; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase