title: Decreased levels of apolipoprotein A-I in plasma of schizophrenic patients.
abstract: This study aims to identify the effects of antipsychotics on plasma proteins, and on the proteins associated with schizophrenia. We applied proteomics technology to screen protein aberrations in Sprague-Dawley rats treated with antipsychotics and schizophrenic patients undergoing medication. ApoA-I was found significantly increased in the chlorpromazine-treated rats and decreased in the patients with treatment-resistant schizophrenia, which suggest that decreased levels of apoA-I might be associated with the pathology of schizophrenia and that chlorpromazine increases apoA-I levels as part of its therapeutic action.
authors.affiliation: Bio-X Center, Shanghai Jiao Tong University, Shanghai, PR China.
authors.forename: Y J
authors.initials: YJ
authors.lastname: La
authors.forename: C L
authors.initials: CL
authors.lastname: Wan
authors.forename: H
authors.initials: H
authors.lastname: Zhu
authors.forename: Y F
authors.initials: YF
authors.lastname: Yang
authors.forename: Y S
authors.initials: YS
authors.lastname: Chen
authors.forename: Y X
authors.initials: YX
authors.lastname: Pan
authors.forename: G Y
authors.initials: GY
authors.lastname: Feng
authors.forename: L
authors.initials: L
authors.lastname: He
mesh_terms: D000328:Adult; D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D016632:Apolipoprotein A-I / Q000097:blood*; D001054:Apolipoproteins A / Q000097:blood; D001057:Apolipoproteins E / Q000097:blood; D015415:Biomarkers / Q000032:analysis / Q000097:blood; D001921:Brain / Q000187:drug effects / Q000378:metabolism / Q000503:physiopathology; D001923:Brain Chemistry / Q000187:drug effects / Q000502:physiology*; D002746:Chlorpromazine / Q000494:pharmacology; D003024:Clozapine / Q000494:pharmacology; D015536:Down-Regulation / Q000187:drug effects / Q000502:physiology; D006801:Humans; D008297:Male; D040901:Proteomics; D051381:Rats; D017207:Rats, Sprague-Dawley; D012559:Schizophrenia / Q000097:blood* / Q000188:drug therapy* / Q000503:physiopathology
chemical_list: D014150:Antipsychotic Agents; D016632:Apolipoprotein A-I; D001054:Apolipoproteins A; D001057:Apolipoproteins E; D015415:Biomarkers; C022205:apolipoprotein A-IV; D003024:Clozapine; D002746:Chlorpromazine