Triple agent immunosuppressive therapy in Vogt-Koyanagi-Harada syndrome.
OBJECTIVE
To describe the role of triple agent immunosuppression in severe recalcitrant cases of Vogt-Koyanagi-Harada syndrome.


METHODS
Retrospective chart review of five cases of Vogt-Koyanagi-Harada syndrome.


RESULTS
All cases were treated with oral prednisolone, azathioprine, and cyclosporine in combination, and rapid remission was observed in all patients. The synergistic effect of the triple agent immunosuppressives helped in preventing recurrences. Prolonged treatment with steroid sparing immunosuppressives in severe and recalcitrant cases of Vogt-Koyanagi-Harada syndrome maintained disease remission.


CONCLUSIONS
Severe cases of Vogt-Koyanagi-Harada syndrome can be treated with early use of high-dose triple agent immunosuppressives.
Agarwal
Mamta
M
Medical Research Foundation, Sankara Nethralaya, Chennai, India.
Ganesh
Sudha K
SK
Biswas
Jyotirmay
J
D000328:Adult; D001379:Azathioprine / Q000627:therapeutic use*; D016572:Cyclosporine / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D005654:Fundus Oculi; D005938:Glucocorticoids / Q000627:therapeutic use*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008875:Middle Aged; D009887:Ophthalmoscopy; D011239:Prednisolone / Q000627:therapeutic use*; D012074:Remission Induction / Q000379:methods; D012189:Retrospective Studies; D014607:Uveomeningoencephalitic Syndrome / Q000188:drug therapy* / Q000473:pathology
D005938:Glucocorticoids; D007166:Immunosuppressive Agents; D016572:Cyclosporine; D011239:Prednisolone; D001379:Azathioprine