[Bioengineering for cartilage and intervertebral disc regeneration].
Cell-based therapy on damaged or degenerative articular cartilage and intervertebral disc promote tissue regeneration by optimized cells and biodegradable matrix. Cell culture is a crucial process to construct the neo-tissue and only means to manipulate cell differentiation and metabolic function prior to implant. Bioreactor, one of the key technology, allows changing culture condition programmed for maximizing tissue regeneration. Incorporating latest biochemical, molecular, and clinical notions, bioengineering means will provide secure treatment to restore functional tissue.
Mizuno
Shuichi
S
Brigham and Women's Hospital, Harvard Medical School, Department of Orthopedic Surgery, USA.
D002356:Cartilage / Q000166:cytology*; D006801:Humans; D007403:Intervertebral Disc / Q000166:cytology*; D023822:Tissue Engineering / Q000379:methods*