title: Synthesis and bioactivity of novel caffeic acid esters from Zuccagnia punctata.
abstract: Synthesis of novel caffeic acid esters (1 and 2) was accomplished starting from appropriately substituted benzaldehydes (3 and 9). While compound 2 exhibited potent anti-oxidative activity in both the nitroblue tetrazolium and 1,1-diphenyl-2-picrylhydrazyl radical-scavenging models, compound 1 showed moderate 5-lipoxygenase inhibitory activity.
authors.affiliation: Laila Impex Research Centre, Unit 1, Phase III, Jawahar Autonagar, Vijayawada, 520 007, India.
authors.forename: M S
authors.initials: MS
authors.lastname: Ramachandra
authors.forename: G V
authors.initials: GV
authors.lastname: Subbaraju
mesh_terms: D000975:Antioxidants / Q000138:chemical synthesis* / Q000378:metabolism; D001547:Benzaldehydes / Q000737:chemistry; D001713:Biphenyl Compounds; D002109:Caffeic Acids / Q000138:chemical synthesis* / Q000737:chemistry; D004952:Esters / Q000138:chemical synthesis; D007887:Fabaceae / Q000737:chemistry*; D016859:Lipoxygenase Inhibitors; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009580:Nitroblue Tetrazolium; D010851:Picrates
chemical_list: C517905:1'-methyl-3'-(3,4-dihyrdoxyphenyl)-propyl caffeate; C517906:1'-methyl-3'-(4-hydroxyphenyl)propyl caffeate; D000975:Antioxidants; D001547:Benzaldehydes; D001713:Biphenyl Compounds; D002109:Caffeic Acids; D004952:Esters; D016859:Lipoxygenase Inhibitors; D010851:Picrates; D009580:Nitroblue Tetrazolium; C004931:1,1-diphenyl-2-picrylhydrazyl