title: Safety assessment of myristic acid as a food ingredient.
abstract: Myristic acid is used in the food industry as a flavor ingredient. It is found widely distributed in fats throughout the plant and animal kingdom, including common human foodstuffs, such as nutmeg. Myristic acid (a 14-carbon, straight-chain saturated fatty acid) has been shown to have a low order of acute oral toxicity in rodents. It may be irritating in pure form to skin and eyes under exaggerated exposure conditions, but is not known or predicted to induce sensitization responses. Myristic acid did not induce a mutagenic response in either bacterial or mammalian systems in vitro. Relevant subchronic toxicity data are available on closely related fatty acid analogs. In particular, a NOEL of >6000mg/kg was reported for lauric acid (a 12-carbon, straight-chain saturated fatty acid) following dietary exposure to male rats for 18 weeks and a NOEL of >5000mg/kg was reported for palmitic acid (a 16-carbon, straight-chain saturated fatty acid) following dietary exposure to rats for 150 days. The data and information that are available indicate that at the current level of intake, food flavoring use of myristic acid does not pose a health risk to humans.
authors.affiliation: Burdock Group, Washington DC 20006, USA. gburdock@burdockgroup.com
authors.forename: George A
authors.initials: GA
authors.lastname: Burdock
authors.forename: Ioana G
authors.initials: IG
authors.lastname: Carabin
mesh_terms: D000042:Absorption; D000818:Animals; D005421:Flavoring Agents / Q000633:toxicity*; D006801:Humans; D019814:Myristic Acid / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000633:toxicity*; D018570:Risk Assessment; D012449:Safety
chemical_list: D005421:Flavoring Agents; D019814:Myristic Acid