Drug release from functionalized oligodeoxynucleotide by photo-induced electron transfer.
We synthesized a photoreactive hairpin-type oligodeoxynucleotide (P-ODN) possessing an o-nitrobenzyl chromophore and a triplet quencher of 1-aminonaphthalene. Photoirradiation of the hybrid of H-ODN with its complementary DNA led to release of drug in an efficient amount, while the photo-induced drug release was remarkably suppressed in the absence of complementary DNA.
Tachi
Yukihiro
Y
Department of Energy and Hydrocarbon Chemistry, Graduate School of Engineering, Kyoto University, Katsura Campus, Kyoto 615-8510, Japan.
Okazaki
Arimichi
A
Tanabe
Kazuhito
K
Hatta
Hiroshi
H
Nishimoto
Sei-ichi
S
D001483:Base Sequence; D019817:Benzoic Acid; D018076:DNA, Complementary / Q000528:radiation effects; D016503:Drug Delivery Systems / Q000379:methods*; D004583:Electrons; D008027:Light; D008969:Molecular Sequence Data; D009690:Nucleic Acid Conformation / Q000528:radiation effects; D009838:Oligodeoxyribonucleotides / Q000737:chemistry* / Q000235:genetics / Q000528:radiation effects*
D018076:DNA, Complementary; D009838:Oligodeoxyribonucleotides; D019817:Benzoic Acid