title: Role of plant CBP/p300-like genes in the regulation of flowering time.
abstract: CREB-binding protein (CBP) and its homolog p300 possess histone acetyltransferase activity and function as key transcriptional co-activators in the regulation of gene expression that controls differentiation and development in animals. However, the role of CBP/p300-like genes in plants has not yet been elucidated. Here, we show that Arabidopsis CBP/p300-like genes promote flowering by affecting the expression of a major floral repressor FLOWERING LOCUS C (FLC). Although animal CBP and p300 generally function as co-activators, Arabidopsis CBP/p300-like proteins are required for the negative regulation of FLC. This CBP/p300-mediated FLC repression may involve reversible protein acetylation independent of histone modification within FLC chromatin.
authors.affiliation: Environmental Biotechnology National Core Research Center, Gyeongsang National University, Jinju, Korea.
authors.forename: Soon-Ki
authors.initials: SK
authors.lastname: Han
authors.forename: Ju-Dong
authors.initials: JD
authors.lastname: Song
authors.forename: Yoo-Sun
authors.initials: YS
authors.lastname: Noh
authors.forename: Bosl
authors.initials: B
authors.lastname: Noh
mesh_terms: D017360:Arabidopsis / Q000235:genetics* / Q000502:physiology*; D029681:Arabidopsis Proteins / Q000235:genetics / Q000378:metabolism*; D035264:Flowers / Q000235:genetics* / Q000502:physiology*; D018506:Gene Expression Regulation, Plant; D051548:Histone Acetyltransferases / Q000235:genetics / Q000378:metabolism; D026161:MADS Domain Proteins / Q000235:genetics / Q000378:metabolism; D016254:Mutagenesis, Insertional; D013997:Time Factors; D050880:p300-CBP Transcription Factors / Q000235:genetics / Q000378:metabolism*
chemical_list: D029681:Arabidopsis Proteins; C418902:At5g10140 protein, Arabidopsis; D026161:MADS Domain Proteins; D051548:Histone Acetyltransferases; D050880:p300-CBP Transcription Factors