Cytosine-gated hole creation and transfer in DNA in aqueous solution.
The selenite radical, SeO3-, has been found to selectively produce the cytosyl radical upon one-electron oxidation of duplex DNA. This is at first a surprising result as SeO3- can only oxidize guanine of the DNA bases, implying that the transiently formed guanyl radical cation must transpose into the neutral cytosyl radical with loss of a proton. Back oxidation to produce the neutral guanyl radical, in competition with another fixation reaction, is observed.
Anderson
Robert F
RF
Department of Chemistry, The University of Auckland, Auckland 1, New Zealand. r.anderson@auckland.ac.nz
Shinde
Sujata S
SS
Maroz
Andrej
A
D003596:Cytosine / Q000737:chemistry*; D004247:DNA / Q000737:chemistry*; D006147:Guanine / Q000737:chemistry; D006860:Hydrogen Bonding; D015394:Molecular Structure; D012996:Solutions; D013057:Spectrum Analysis
D012996:Solutions; D006147:Guanine; D003596:Cytosine; D004247:DNA