Synthesis and biological activity of phosphonated nucleosides: part 1. Furanose, carbocyclic and heterocyclic analogues.
Phosphonated nucleosides represent a promising alternative in the improvement of the biological activity of nucleoside analogues in antiviral and anticancer chemotherapy. The basic concept, the chemistry, the different structural modifications and their effects on the antiviral potency will be discussed in this review.
Piperno
Anna
A
Dipartimento Farmaco-Chimico, Universita' degli Studi di Messina, Viale S.S. Annunziata, 98168 Messina, Italy. apiperno@pharma.unime.it
Chiacchio
Maria A
MA
Iannazzo
Daniela
D
Romeo
Roberto
R
D005663:Furans / Q000737:chemistry* / Q000494:pharmacology*; D009705:Nucleosides / Q000138:chemical synthesis* / Q000494:pharmacology*; D017553:Phosphorus Compounds / Q000737:chemistry
D005663:Furans; D009705:Nucleosides; D017553:Phosphorus Compounds