title: Evaluation of novel one-electron reduction with metal in DNA.
abstract: Indium(0) is known to work as a good one-electron reductant with a small first ionization potential. Additionally, this metal is very stable in aqueous media. Therefore, indium has a bright prospect of developing a new method for the site-selective reduction of biopolymers. In this paper, the reduction of 5-halouracils with indium in aqueous solution is reported. We prepared four halouracils, i.e., 5-fluorouracil, 5-chlorouracil, 5-bromouracil, and 5-iodouracil, and evaluated their reduction with indium in water. Incubation of 5-bromouracil and 5-iodouracil with sonication in the presence of indium efficiently caused dehalogenation to uracil. Natural nucleobases (G, A, C, T and U) were not damaged by indium under the same reaction condition.
authors.affiliation: Frontier Research System, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.
authors.forename: Kazuo
authors.initials: K
authors.lastname: Tanaka
authors.forename: Taku
authors.initials: T
authors.lastname: Kamei
authors.forename: Akimitsu
authors.initials: A
authors.lastname: Okamoto
mesh_terms: D001976:Bromouracil / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D004247:DNA / Q000737:chemistry; D004583:Electrons; D007204:Indium / Q000737:chemistry*; D014498:Uracil / Q000031:analogs & derivatives* / Q000737:chemistry
chemical_list: D007204:Indium; D001976:Bromouracil; D014498:Uracil; D004247:DNA; C048747:5-iodouracil