[Effects of ferrous sulfate supplementation on bone marrow hemopoiesis in rats].
OBJECTIVE
To explore the influences of different dosage ferrous sulfate supplements on bone marrow hemopoiesis in rats.


METHODS
Female weaning Wistar rats were fed with an iron deficient diet (< 10 mg/kg diet) until the level of hemoglobin of rats was lower than 100 g/L. Rats (n = 50) were randomly divided into five groups according to the levels of hemoglobin and body weight, iron deficiency control (ID), daily low iron diet supplement (LDs), daily high iron diet supplement (HDs), weekly low iron supplement (LWs), and weekly high iron supplement (HWs).


RESULTS
After 12 weeks, bone marrow stainable iron was seldom in ID group, and ample in supplement groups. The proportions of iron staining of bone marrow smear in supplement groups were more than 30%. Bone marrow cells in all rats were hyperplastic or active hyperplastic.


CONCLUSIONS
Daily high iron supplement or once weekly high iron supplement were safe to bone marrow hemopoiesis in rats.
Yang
Qing-jun
QJ
Beijing Xicheng District Center for Disease Prevention and Control, Beijing 100029, China.
Lai
Jian-qiang
JQ
Meng
Jing
J
Xing
Bao-Li
BL
Liu
Hui
H
Yin
Shi-an
SA
Zhao
Xian-feng
XF
Xu
Qing-mei
QM
D018798:Anemia, Iron-Deficiency / Q000188:drug therapy*; D000818:Animals; D001853:Bone Marrow / Q000187:drug effects*; D004195:Disease Models, Animal; D005260:Female; D005296:Ferrous Compounds / Q000494:pharmacology*; D006410:Hematopoiesis / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar
D005296:Ferrous Compounds; C020748:ferrous sulfate