Oncogene addiction: role of signal attenuation.
Tumors can become dependent upon signaling by oncogenes. In a recent issue of Cancer Cell, Sharma et al. (2006b) reported that "oncogene addiction" may be mediated by differential rates of signal attenuation of proapoptotic and prosurvival pathways.
Hübner
Anette
A
Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA.
Jaeschke
Anja
A
Davis
Roger J
RJ
D017209:Apoptosis; D049109:Cell Proliferation; D006801:Humans; D009369:Neoplasms / Q000235:genetics*; D015513:Oncogene Proteins / Q000235:genetics; D009857:Oncogenes / Q000235:genetics*; D015398:Signal Transduction
D015513:Oncogene Proteins