Selected pharmacokinetic issues in patients with chronic kidney disease.
Pharmacotherapy plays an important role in the care of a chronic kidney disease (CKD) patient but delivering this therapy can be challenging. Besides alterations in the pharmacokinetic parameters of absorption, distribution, metabolism and elimination, the average CKD patient must take multiple medications each day. The likelihood of an adverse drug reaction increases with each medication added to these patients' daily regimen. In this article we discuss selected pharmacokinetic issues unique to CKD patients.
Churchwell
Mariann D
MD
Department of Pharmacy Practice, University of Toledo College of Pharmacy, Toledo, Ohio, USA.
Mueller
Bruce A
BA
D004305:Dose-Response Relationship, Drug; D064420:Drug-Related Side Effects and Adverse Reactions; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications / Q000188:drug therapy*; D008286:Malabsorption Syndromes / Q000150:complications* / Q000209:etiology; D010599:Pharmacokinetics