First attempts at prediction of DNA strand-break yields using nanodosimetric data.
We present the first results of our attempts to correlate yields of ionisation clusters in a gas model of DNA and corresponding double-strand break (DSB) yields in irradiated plasmids, using a simple statistical model of DNA lesion formation. Based on the same statistical model, we also provide a comparison of simulated nanodosimetric data for electrons and published DSB yields obtained with the PARTRAC code.
Garty
G
G
Department of Particle Physics, Weizmann Institute of Science, Rehovot, Israel. gyg2101@columbia.edu
Schulte
R
R
Shchemelinin
S
S
Grosswendt
B
B
Leloup
C
C
Assaf
G
G
Breskin
A
A
Chechik
R
R
Bashkirov
V
V
D000465:Algorithms; D003198:Computer Simulation; D004247:DNA / Q000737:chemistry* / Q000528:radiation effects*; D004249:DNA Damage; D016208:Databases, Factual; D004307:Dose-Response Relationship, Radiation; D008832:Microchemistry / Q000379:methods; D008956:Models, Chemical; D008957:Models, Genetic; D036103:Nanotechnology / Q000379:methods*; D010865:Pilot Projects; D011829:Radiation Dosage; D011874:Radiometry / Q000379:methods*
D004247:DNA