title: Synthesis of an advanced intermediate en route to the mitomycin natural products.
abstract: [Structure: see text] An advanced intermediate in our planned synthesis of mitomycin C has been acquired in nine steps from tert-butyl glyoxylate. The aziridinyl pyrrolidine and quinone subunits are coupled regioselectively to arrive at an enamine that is prepared for C10 homologation.
authors.affiliation: Department of Chemistry, Vanderbilt University, Nashville, Tennessee 37235-1822, USA.
authors.forename: Amie L
authors.initials: AL
authors.lastname: Williams
authors.forename: Jayasree M
authors.initials: JM
authors.lastname: Srinivasan
authors.forename: Jeffrey N
authors.initials: JN
authors.lastname: Johnston
mesh_terms: D001688:Biological Products / Q000138:chemical synthesis*; D016685:Mitomycin / Q000138:chemical synthesis*
chemical_list: D001688:Biological Products; D016685:Mitomycin