Microchimeric cells in systemic lupus erythematosus: targets or innocent bystanders?
During pregnancy maternal and fetal cells commute back and forth leading to fetal microchimerism in the mother and maternal microchimerism in the child that can persist for years after the birth. Chimeric fetal and maternal cells can be hematopoietic or can differentiate into somatic cells in multiple organs, potentially acting as targets for 'autoimmunity' and so have been implicated in the pathogenesis of autoimmune diseases that resemble graft-versus-host disease after stem cell transplantation. Fetal cells have been found in women with systemic lupus erythematosus, both in the blood and a target organ, the kidney, suggesting that they may be involved in pathogenesis. Future studies will address how the host immune system normally tolerates maternal and fetal cells or how the balance may change during autoimmunity.
Stevens
A M
AM
Department of Pediatrics, University of Washington, Childrens Hospital and Regional Medical Center, 307 Westlake Ave N, Suite 300, Seattle, WA 98109, Washington, USA. anne.stevens@seattlechildrens.org
D000483:Alleles; D000818:Animals; D001327:Autoimmune Diseases / Q000196:embryology / Q000235:genetics / Q000276:immunology / Q000473:pathology; D015551:Autoimmunity / Q000235:genetics; D046528:Chimerism / Q000196:embryology; D002986:Clinical Trials as Topic; D005260:Female; D005333:Fetus / Q000276:immunology / Q000473:pathology*; D006086:Graft vs Host Disease / Q000196:embryology / Q000209:etiology / Q000473:pathology; D006801:Humans; D007231:Infant, Newborn; D008180:Lupus Erythematosus, Systemic / Q000196:embryology* / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D008297:Male; D008431:Maternal-Fetal Exchange / Q000235:genetics / Q000276:immunology; D011247:Pregnancy; D014180:Transplantation / Q000009:adverse effects