title: Emergence and dissemination of Enterobacteriaceae isolates producing CTX-M-1-like enzymes in Spain are associated with IncFII (CTX-M-15) and broad-host-range (CTX-M-1, -3, and -32) plasmids.
abstract: The spread of CTX-M-1-like enzymes in Spain is associated with particular plasmids of broad-host-range IncN (blaCTX-M-32, blaCTX-M-1), IncL/M (blaCTX-M-1), and IncA/C2 (blaCTX-M-3) or narrow-host-range IncFII (blaCTX-M-15). The identical genetic surroundings of blaCTX-M-32 and blaCTX-M-1 and their locations on related 40-kb IncN plasmids indicate the in vivo evolution of this element.
authors.affiliation: Servicio de Microbiología, Hospital Universitario Ramón y Cajal, IMSALUD, Carretera de Colmenar, km. 9.1, Madrid 28034, Spain.
authors.forename: Angela
authors.initials: A
authors.lastname: Novais
authors.forename: Rafael
authors.initials: R
authors.lastname: Cantón
authors.forename: Raquel
authors.initials: R
authors.lastname: Moreira
authors.forename: Luísa
authors.initials: L
authors.lastname: Peixe
authors.forename: Fernando
authors.initials: F
authors.lastname: Baquero
authors.forename: Teresa M
authors.initials: TM
authors.lastname: Coque
mesh_terms: D024881:Drug Resistance, Bacterial; D004755:Enterobacteriaceae / Q000201:enzymology* / Q000235:genetics / Q000302:isolation & purification; D019143:Evolution, Molecular; D006801:Humans; D010957:Plasmids; D013030:Spain; D001618:beta-Lactamases / Q000096:biosynthesis / Q000235:genetics / Q000378:metabolism
chemical_list: C473109:beta-lactamase CTX-M-15; C417271:beta-lactamase CTX-M-3; C055184:beta-lactamase TEM-3; D001618:beta-Lactamases; C487656:beta-lactamase CTX-M-32, E coli