title: Use of s-100 and chromogranin a antibodies as immunohistochemical markers on detection of malignancy in aortic body tumors in dog.
abstract: To define the characteristics of malignancy we performed routine histology and an immunohistochemical study on seventeen aortic body tumors in dogs. We essayed tumors using a panel of immunohistochemical markers: neuron specific enolase (NSE), chromogranin A (CrA) and S-100. Among 17 cases, the neoplastic cells were positive for NSE (17 cases, 100%), S-100 (9 cases, 53%), and CrA (8 cases, 47%), respectively. The sustentacular cells density and chief cell staining intensity were both inversely related to tumor grade. The most relevant data was consistent with a negative staining of S-100 correlated with absence or decreased number of sustentacular cells in tumors grade III. This report indicates that the immunohistochemical panel has utility for the diagnosis of chemodectoma and the negative staining to CrA and S-100 markers in tumors grade III expresses an indication of malignant behaviour of the tumor.
authors.affiliation: Department of Animal Pathology, Faculty of Veterinary Medicine, University of Torino, Grugliasco, Italy.
authors.forename: Luca
authors.initials: L
authors.lastname: Aresu
authors.forename: Massimiliano
authors.initials: M
authors.lastname: Tursi
authors.forename: Selina
authors.initials: S
authors.lastname: Iussich
authors.forename: Franco
authors.initials: F
authors.lastname: Guarda
authors.forename: Federico
authors.initials: F
authors.lastname: Valenza
mesh_terms: D000367:Age Factors; D000818:Animals; D001016:Aortic Bodies / Q000276:immunology / Q000473:pathology*; D053379:Chromogranin A; D004283:Dog Diseases / Q000175:diagnosis* / Q000276:immunology*; D004285:Dogs; D005260:Female; D007150:Immunohistochemistry / Q000662:veterinary; D008297:Male; D010524:Peripheral Nervous System Neoplasms / Q000175:diagnosis / Q000276:immunology / Q000662:veterinary*; D009418:S100 Proteins; D013045:Species Specificity
chemical_list: D053379:Chromogranin A; D009418:S100 Proteins