title: Amino disaccharides having an alpha-(1-->4) or a beta-(1-->4) linkage, their synthesis and evaluation as a potential inhibitor for HIV-1 TAR-Tat.
abstract: Amino disaccharides having an alpha-(1-->4) linkage or a beta-(1-->4) linkage have been prepared as the mimics of amino glycoside antibiotics and their inhibition for HIV-1 TAR-Tat were examined. The compound having alpha-(1-->4) linkage denotes better inhibition for TAR-Tat than that of the one having beta-(1-->4).
authors.affiliation: Shibaura Institute of Technology, Department of Applied Chemistry.
authors.forename: Takashi
authors.initials: T
authors.lastname: Iguchi
authors.forename: Hirohumi
authors.initials: H
authors.lastname: Ishikawa
authors.forename: Hiroharu
authors.initials: H
authors.lastname: Matumoto
authors.forename: Mamoru
authors.initials: M
authors.lastname: Mizuno
authors.forename: Kohtaro
authors.initials: K
authors.lastname: Goto
authors.forename: Keita
authors.initials: K
authors.lastname: Hamasaki
mesh_terms: D019380:Anti-HIV Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D004187:Disaccharides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D015696:Gene Products, tat / Q000037:antagonists & inhibitors*; D016325:HIV Long Terminal Repeat / Q000187:drug effects; D015497:HIV-1 / Q000187:drug effects*; D054322:tat Gene Products, Human Immunodeficiency Virus
chemical_list: C520203:2-aminoethyl 6-amino-6-deoxyglucosaminyl-1-4-2,6-diamino-2,6-dideoxyglucopyranoside; D019380:Anti-HIV Agents; D004187:Disaccharides; D015696:Gene Products, tat; D054322:tat Gene Products, Human Immunodeficiency Virus