title: Streptococcus pneumoniae pilus subunits protect mice against lethal challenge.
abstract: Streptococcus pneumoniae is a major public health threat worldwide. The recent discovery that this pathogen possesses pili led us to investigate their protective abilities in a mouse model of intraperitoneal infection. Both active and passive immunization with recombinant pilus subunits afforded protection against lethal challenge with the S. pneumoniae serotype 4 strain TIGR4.
authors.affiliation: Novartis Vaccines and Diagnostics s.r.l., Research Center, Via Fiorentina 1, I-53100 Siena, Italy.
authors.forename: Claudia
authors.initials: C
authors.lastname: Gianfaldoni
authors.forename: Stefano
authors.initials: S
authors.lastname: Censini
authors.forename: Markus
authors.initials: M
authors.lastname: Hilleringmann
authors.forename: Monica
authors.initials: M
authors.lastname: Moschioni
authors.forename: Claudia
authors.initials: C
authors.lastname: Facciotti
authors.forename: Werner
authors.initials: W
authors.lastname: Pansegrau
authors.forename: Vega
authors.initials: V
authors.lastname: Masignani
authors.forename: Antonello
authors.initials: A
authors.lastname: Covacci
authors.forename: Rino
authors.initials: R
authors.lastname: Rappuoli
authors.forename: Michèle Anne
authors.initials: MA
authors.lastname: Barocchi
authors.forename: Paolo
authors.initials: P
authors.lastname: Ruggiero
mesh_terms: D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood; D000942:Antigens, Bacterial / Q000008:administration & dosage / Q000276:immunology*; D016470:Bacteremia; D004195:Disease Models, Animal; D005260:Female; D010861:Fimbriae, Bacterial / Q000276:immunology*; D007116:Immunization, Passive; D051379:Mice; D008807:Mice, Inbred BALB C; D011008:Pneumococcal Infections / Q000517:prevention & control*; D022242:Pneumococcal Vaccines / Q000276:immunology*; D013296:Streptococcus pneumoniae / Q000276:immunology*; D016019:Survival Analysis; D014611:Vaccination; D022223:Vaccines, Subunit / Q000276:immunology; D014614:Vaccines, Synthetic / Q000276:immunology
chemical_list: D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D022242:Pneumococcal Vaccines; D022223:Vaccines, Subunit; D014614:Vaccines, Synthetic