Gender differences in AIDS-associated Kaposi sarcoma in Harare, Zimbabwe.
Reasons for gender-related differences in the risk of AIDS-related Kaposi sarcoma (AIDS-KS) are unknown. Four hundred thirty-eight male and 166 female AIDS-KS patients were evaluated in Harare, Zimbabwe. Female patients were younger than male patients in this study (median of 33 vs. 38 years; P < 0.001), mirroring the epidemiology of AIDS in Zimbabwe. In a multivariate model adjusted for CD4 T-cell count, age, prior radiation treatment, and chemotherapy, women were more likely to report fever, diaphoresis, or weight loss (odds ratio = 1.7, 95% confidence interval: 1.1 to 2.7; P = 0.009). These findings suggest an increased severity of KS or other unidentified infections among women with AIDS-KS in Zimbabwe.
Meditz
Amie L
AL
Division of Infectious Diseases, Department of Medicine, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA.
Borok
Margaret
M
MaWhinney
Samantha
S
Gudza
Ivy
I
Ndemera
Buxton
B
Gwanzura
Lovemore
L
Campbell
Thomas B
TB
D017088:AIDS-Related Opportunistic Infections / Q000503:physiopathology*; D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D005334:Fever; D005783:Gender Identity; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012514:Sarcoma, Kaposi / Q000503:physiopathology*; D012727:Sex Characteristics; D013546:Sweating; D015431:Weight Loss; D015030:Zimbabwe