Is mega dose of methotrexate beneficial to patients with acute lymphoblastic leukemia?
Pui
Ching-Hon
CH
Departments of Oncology and Pharmaceutical Sciences, St Jude Children's Research Hospital, and Colleges of Medicine and Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee 38105, USA. ching-hon.pui@stjude.org
Relling
Mary V
MV
Evans
William E
WE
D002490:Central Nervous System / Q000187:drug effects; D016543:Central Nervous System Neoplasms / Q000188:drug therapy; D002648:Child; D002986:Clinical Trials as Topic; D006801:Humans; D002955:Leucovorin / Q000627:therapeutic use; D008727:Methotrexate / Q000627:therapeutic use*; D010865:Pilot Projects; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy*; D016032:Randomized Controlled Trials as Topic; D012008:Recurrence; D012306:Risk
D002955:Leucovorin; D008727:Methotrexate