title: Murray Valley encephalitis in an adult traveller complicated by long-term flaccid paralysis: case report and review of the literature.
abstract: Murray Valley encephalitis (MVE) virus, a mosquito-borne flavivirus, is the most common cause of viral encephalitis in the tropical 'Top End' of northern Australia. Clinical encephalitis due to MVE virus has a mortality rate of approximately 30%, with a similar proportion of patients being left with significant neurological deficits. We report the case of a 25-year-old man from the UK who acquired MVE while travelling through northern Australia. He required prolonged admission to the Intensive Care Unit and several years later remains partly ventilator-dependent, with flaccid quadriparesis. To our knowledge, this is the first reported case of MVE virus-induced flaccid paralysis in an adult in northern Australia, although it is well described in children. Paralysis was thought to be due to anterior horn cell involvement in the spinal cord and extensive bilateral thalamic destruction, both of which are well recognised complications of infection with MVE virus. Cases of flaccid paralysis with similar pathology have been described following infection with the related flavivirus Japanese encephalitis virus as well as more recently with West Nile virus. Our case highlights the potential severity of flavivirus-induced encephalitis and the importance of avoiding mosquito bites while travelling through endemic areas.
authors.affiliation: Royal Darwin Hospital, PO Box 41326, Casuarina, NT 0811, Australia. mark_douglas@emi.usyd.edu.au
authors.forename: Mark W
authors.initials: MW
authors.lastname: Douglas
authors.forename: Dianne P
authors.initials: DP
authors.lastname: Stephens
authors.forename: James N C
authors.initials: JN
authors.lastname: Burrow
authors.forename: Nicholas M
authors.initials: NM
authors.lastname: Anstey
authors.forename: Kevin
authors.initials: K
authors.lastname: Talbot
authors.forename: Bart J
authors.initials: BJ
authors.lastname: Currie
mesh_terms: D000328:Adult; D018068:Encephalitis Virus, Murray Valley; D004671:Encephalitis, Arbovirus / Q000150:complications* / Q000175:diagnosis; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D010243:Paralysis / Q000821:virology*; D014057:Tomography, X-Ray Computed; D014195:Travel