Transient expression of bone morphogenic protein-2 in acute liver injury by carbon tetrachloride.
Acute liver injury induced by administration of carbon tetrachloride (CCl4) was shown to be a model of wound-repair in rat liver. Albumin gene expression was significantly reduced at 24 h post injection with CCl4, but recovered at 48 h. We also observed significant and transient expression of bone morphogenic protein-2 (BMP-2) at 6-24 h post treatment. This expression was also shown with depletion of Kupffer cell by GdCl3, and immunostaining with anti-BMP-2 antibody showed BMP-2-producing cells interspersed in intralobular spaces of injured liver. These observations suggest that BMP-2 secreted from oval-like cells plays important roles in the wound healing response of injured liver.
Nakatsuka
Ryusuke
R
Division of Molecular Biology, Department of Molecular and Cellular Biology, School of Life Sciences, Faculty of Medicine, Graduate School of Medicine, Tottori University, Yonago 683-8503, Japan. kensato@grape.med.tottori-u.ac.jp
Taniguchi
Makoto
M
Hirata
Mitsuhi
M
Shiota
Goshi
G
Sato
Kenzo
K
D000818:Animals; D055396:Bone Morphogenetic Protein 2; D019485:Bone Morphogenetic Proteins / Q000096:biosynthesis* / Q000276:immunology; D002252:Carbon Tetrachloride Poisoning / Q000503:physiopathology*; D056486:Chemical and Drug Induced Liver Injury; D019791:Guanidine / Q000494:pharmacology; D022781:Hepatocytes / Q000187:drug effects; D007728:Kupffer Cells / Q000187:drug effects; D018950:Lipopolysaccharide Receptors / Q000096:biosynthesis; D008107:Liver Diseases / Q000503:physiopathology; D008115:Liver Regeneration / Q000235:genetics / Q000502:physiology; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D016212:Transforming Growth Factor beta / Q000096:biosynthesis* / Q000276:immunology
C525720:Bmp2 protein, rat; D055396:Bone Morphogenetic Protein 2; D019485:Bone Morphogenetic Proteins; D018950:Lipopolysaccharide Receptors; D016212:Transforming Growth Factor beta; D019791:Guanidine