title: [Experimental study on anti-tumor effect of extractive from Celastrus orbiculatus in vivo].
abstract: OBJECTIVE
  To study the anti-tumor activity of extractive from Celastrus orbiculatus in vivo.
  
  
  METHODS
  Mice bearing transplanted tumor S180 and Heps were used to study the effects of acetoacetate and n-butanol extractive from C. orbiculatus. The changes in serum contents of SOD and malondialdehyde (MDA) content were assayed.
  
  
  RESULTS
  Acetoacetate and n-butanol extractive from C. orbiculatus significantly inhibited the growth of S180 and Heps tumor in mice. SOD content was obviously increased, MDA content obviously decreased in the serum after extractive treatment.
  
  
  CONCLUSIONS
  Acetoacetate and n-butanol extractive from C. orbiculatus have anti-tumor effects and anti-oxidative capacity.
authors.affiliation: Medical School of Yangzhou University, Yangzhou 225001, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Zhang
authors.forename: Yun-Ming
authors.initials: YM
authors.lastname: Xu
authors.forename: Wei-Min
authors.initials: WM
authors.lastname: Wang
authors.forename: Yan-Qing
authors.initials: YQ
authors.lastname: Liu
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology*; D000975:Antioxidants / Q000302:isolation & purification / Q000494:pharmacology; D031247:Celastrus / Q000737:chemistry; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D005260:Female; D008114:Liver Neoplasms, Experimental / Q000097:blood / Q000473:pathology; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D051379:Mice; D008813:Mice, Inbred ICR; D009368:Neoplasm Transplantation; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D012510:Sarcoma 180 / Q000097:blood / Q000473:pathology*; D013482:Superoxide Dismutase / Q000097:blood
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D000975:Antioxidants; D004365:Drugs, Chinese Herbal; D008315:Malondialdehyde; D013482:Superoxide Dismutase