title: Bowen's disease with invasive adnexal carcinoma: the pluripotential nature of Bowen's disease cells.
abstract: Bowen's disease rarely exhibits multiple combinations of premalignant and/or malignant skin lesions. Bowen's disease with invasive adnexal carcinoma was originally described by Kao, but is not well recognized by clinicians due to its rarity and lack of specific clinical features of this condition. Herein, we describe three unusual cases of Bowen's disease with invasive adnexal carcinoma. The two distinct neoplastic areas exhibited continuity both clinically and histologically. The plaque lesions possessed clinical features typical of Bowen's disease. In cases 1 and 3, we confirmed the adnexal tumor within tumors of Bowen's disease, the diagnosis of which is eccrine porocarcinoma. The tumor in case 2 was characteristic to trichilemmal carcinoma. Immunohistochemically, the tumor cells of Bowen's disease and the adnexal carcinoma differed in antigenicities. The present cases support a notion that Bowen's disease maintains a pluripotential nature.
authors.affiliation: Department of Dermatology, Graduate School of Medicine, Gifu University, Gifu, Japan. kamihide@cc.gifu-u.ac.jp
authors.forename: Hideki
authors.initials: H
authors.lastname: Kamiya
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Kitajima
authors.forename: Masanori
authors.initials: M
authors.lastname: Ban
mesh_terms: D018250:Acrospiroma / Q000473:pathology; D000368:Aged; D000369:Aged, 80 and over; D001913:Bowen's Disease / Q000473:pathology*; D018280:Carcinoma, Skin Appendage / Q000473:pathology*; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D005260:Female; D006801:Humans; D009361:Neoplasm Invasiveness; D018295:Neoplasms, Basal Cell / Q000473:pathology; D012878:Skin Neoplasms / Q000473:pathology*