title: Cytogenetic investigation in Iranian patients suspected with Fanconi anemia.
abstract: We present our study on 318 patients suspected with Fanconi anemia (FA) referred to The Iranian Blood Transfusion Organization during the period of 4 years. Mitomycin C (MMC) was used as a DNA cross-linker to study chromosomal breakage. In total 61 positive cases were diagnosed cytogenetically. The ratio of women being affected was slightly higher than men. Comparison of several hematologic and clinical parameters in FA (MMC positive) and non-FA (MMC negative) patients showed no clinically significant differences. This study also indicates that this sort of test is very useful and essential for accurate diagnosis of patients with FA with or without congenital anomalies.
authors.affiliation: Research Centre of Iranian Blood Transfusion Organization, Hemmat Avenue, Tehran, Iran.
authors.forename: Sameeramis
authors.initials: S
authors.lastname: Tootian
authors.forename: Frouzandeh
authors.initials: F
authors.lastname: Mahjoubi
authors.forename: Mitra
authors.initials: M
authors.lastname: Rahnama
authors.forename: Fabyola
authors.initials: F
authors.lastname: Hormozian
authors.forename: Farzaneh
authors.initials: F
authors.lastname: Mortezapour
authors.forename: Faegeh
authors.initials: F
authors.lastname: Razazian
authors.forename: Farnoosh
authors.initials: F
authors.lastname: Manoochehri
authors.forename: Mahsa
authors.initials: M
authors.lastname: Zamanian
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Nasiri
authors.forename: Saeedeh
authors.initials: S
authors.lastname: Soleymani
authors.forename: Ladan
authors.initials: L
authors.lastname: Seyedmortaz
mesh_terms: D019457:Chromosome Breakage / Q000187:drug effects; D003582:Cytogenetics / Q000379:methods; D005199:Fanconi Anemia / Q000175:diagnosis* / Q000235:genetics; D005260:Female; D006801:Humans; D007492:Iran; D008297:Male; D016685:Mitomycin / Q000494:pharmacology; D019384:Nucleic Acid Synthesis Inhibitors / Q000494:pharmacology; D012189:Retrospective Studies
chemical_list: D019384:Nucleic Acid Synthesis Inhibitors; D016685:Mitomycin