Chemical and biological consequences of locking the conformation of nucleosides at the two antipodal extremes of the pseudorotational cycle.
It is shown that in spite of the low energy barrier for the North (N)/South (S) equilibrium in nucleosides, enzymes show measurable differences in binding and/or catalytic activity between the two antipodal conformations.
Marquez
Victor E
VE
Laboratory of Medicinal Chemistry, Center for Cancer Research, National Cancer Institute-Frederick, National Institutes of Health, Frederick, MD 21702, USA.
D000818:Animals; D002522:Chlorocebus aethiops; D004798:Enzymes / Q000378:metabolism; D018259:Herpesvirus 1, Human / Q000502:physiology; D009690:Nucleic Acid Conformation; D009705:Nucleosides / Q000737:chemistry* / Q000378:metabolism*; D018047:Receptors, Purinergic P1 / Q000378:metabolism; D013329:Structure-Activity Relationship; D014709:Vero Cells
D004798:Enzymes; D009705:Nucleosides; D018047:Receptors, Purinergic P1