title: [Laboratory evolutive aspects of children under paracoccidioidomycosis treatment].
abstract: The study of 38 children with paracoccidioidomycosis, aged up to 14, treated for 24 to 30 months with either a sulfonamide derivative or ketoconazole either alone or, after the use of amphotericin B. Laboratory data at admission were analyzed and compared with those of sequential tests after up to 30 months follow-up. Anemia, eosinophilia, increased bilirubin and aminotransferases normalized, in most patients, after three months treatment and hypoalbuminemia normalized after six months, suggesting that these laboratory findings are useful for monitoring early therapeutic response. Peripheral leucocytes, erythrocyte sedimentation rate, IgG, and serological titers for Paracoccidioides brasiliensis were increased and frequently normalized after nine to 12 months of treatment. They may be useful for monitoring the entire treatment and emphasize the need for long term treatment of paracoccidioidomycosis in children.
authors.affiliation: Hospital das Clinicas, Faculdade de Medicina, Universidade Federal do Estado de Minas Gerais, Belo Horizonte, MG. dagor@uol.com.br
authors.forename: Maria Gorete dos Santos
authors.initials: MG
authors.lastname: Nogueira
authors.forename: Gláucia Manzan Queiroz
authors.initials: GM
authors.lastname: Andrade
authors.forename: Edward
authors.initials: E
authors.lastname: Tonelli
authors.forename: Susana Nogueira
authors.initials: SN
authors.lastname: Diniz
authors.forename: Alfredo Miranda
authors.initials: AM
authors.lastname: Goes
authors.forename: Patrícia Silva
authors.initials: PS
authors.lastname: Cisalpino
mesh_terms: D000293:Adolescent; D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D002648:Child; D005500:Follow-Up Studies; D006801:Humans; D007654:Ketoconazole / Q000627:therapeutic use; D010229:Paracoccidioidomycosis / Q000097:blood* / Q000188:drug therapy*; D013449:Sulfonamides / Q000627:therapeutic use; D013997:Time Factors
chemical_list: D000935:Antifungal Agents; D013449:Sulfonamides; D000666:Amphotericin B; D007654:Ketoconazole