Neoplastic transformation of a human hybrid cell line by alpha particles in relation to mammography X rays.
The hybrid cell line CGL1 is the only cell line which allows quantitation of neoplastic transformation in human cells. Hybrid cells were exposed to 3.4 MeV alpha particles or to mammography X rays (29 kV(p)) and both survival and neoplastic cell transformation were assayed. For comparison, previously published data obtained with 200 kV(p) X rays are also included. Alpha particles were significantly more efficient than 29 kV(p) X rays in cell killing. Surprisingly, the efficiency of mammography X rays for the induction of neoplastic cell transformation was close to that observed for alpha particles.
Frankenberg-Schwager
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M
University of Goettingen, Center of Radiology, Department of Nuclear Medicine, Von-Siebold-Strasse 3, D-37075 Goettingen, Germany.
Spieren
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S
Pralle
E
E
Frankenberg
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D
D000512:Alpha Particles; D002460:Cell Line; D002470:Cell Survival / Q000528:radiation effects*; D002471:Cell Transformation, Neoplastic / Q000473:pathology* / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D006367:HeLa Cells; D006801:Humans; D006825:Hybridomas / Q000473:pathology* / Q000528:radiation effects*; D008327:Mammography; D011829:Radiation Dosage; D014965:X-Rays