title: Physical activity and risk of colon and rectal cancers: the European prospective investigation into cancer and nutrition.
abstract: We investigated several aspects of the role of physical activity in colon and rectal cancer etiology that remain unclear in the European Prospective Investigation into Nutrition and Cancer. This cohort of 413,044 men and women had 1,094 cases of colon and 599 cases of rectal cancer diagnosed during an average of 6.4 years of follow-up. We analyzed baseline data on occupational, household, and recreational activity to examine associations by type of activity, tumor subsite, body mass index (BMI), and energy intake. The multivariate hazard ratio for colon cancer was 0.78 [95% confidence interval (95% CI), 0.59-1.03] among the most active participants when compared with the inactive, with evidence of a dose-response effect (P(trend) = 0.04). For right-sided colon tumors, the risk was 0.65 (95% CI, 0.43-1.00) in the highest quartile of activity with evidence of a linear trend (P(trend) = 0.004). Active participants with a BMI under 25 had a risk of 0.63 (95% CI, 0.39-1.01) for colon cancer compared with the inactive. Finally, an interaction between BMI and activity (P(interaction) = 0.03) was observed for right-sided colon cancers; among moderately active and active participants with a BMI under 25, a risk of 0.38 (95% CI, 0.21-0.68) was found as compared with inactive participants with BMI >30. No comparable decreased risks were observed for rectal cancer for any type of physical activity for any subgroup analyses or interactions considered. We found that physical activity reduced colon cancer risk, specifically for right-sided tumors and for lean participants, but not rectal cancer.
authors.affiliation: Nutrition and Hormones Group, IARC, Lyon, France. chrisf@cancerboard.ab.ca
authors.forename: Christine
authors.initials: C
authors.lastname: Friedenreich
authors.forename: Teresa
authors.initials: T
authors.lastname: Norat
authors.forename: Karen
authors.initials: K
authors.lastname: Steindorf
authors.forename: Marie-Christine
authors.initials: MC
authors.lastname: Boutron-Ruault
authors.forename: Tobias
authors.initials: T
authors.lastname: Pischon
authors.forename: Mathieu
authors.initials: M
authors.lastname: Mazuir
authors.forename: Françoise
authors.initials: F
authors.lastname: Clavel-Chapelon
authors.forename: Jakob
authors.initials: J
authors.lastname: Linseisen
authors.forename: Heiner
authors.initials: H
authors.lastname: Boeing
authors.forename: Manuela
authors.initials: M
authors.lastname: Bergman
authors.forename: Nina Fons
authors.initials: NF
authors.lastname: Johnsen
authors.forename: Anne
authors.initials: A
authors.lastname: Tjønneland
authors.forename: Kim
authors.initials: K
authors.lastname: Overvad
authors.forename: Michelle
authors.initials: M
authors.lastname: Mendez
authors.forename: J Ramón
authors.initials: JR
authors.lastname: Quirós
authors.forename: Carmen
authors.initials: C
authors.lastname: Martinez
authors.forename: Miren
authors.initials: M
authors.lastname: Dorronsoro
authors.forename: Carmen
authors.initials: C
authors.lastname: Navarro
authors.forename: Aurelio Barricarte
authors.initials: AB
authors.lastname: Gurrea
authors.forename: Sheila
authors.initials: S
authors.lastname: Bingham
authors.forename: Kay-Tee
authors.initials: KT
authors.lastname: Khaw
authors.forename: Naomi
authors.initials: N
authors.lastname: Allen
authors.forename: Tim
authors.initials: T
authors.lastname: Key
authors.forename: Antonia
authors.initials: A
authors.lastname: Trichopoulou
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Trichopoulos
authors.forename: Natassa
authors.initials: N
authors.lastname: Orfanou
authors.forename: Vittorio
authors.initials: V
authors.lastname: Krogh
authors.forename: Domenico
authors.initials: D
authors.lastname: Palli
authors.forename: Rosario
authors.initials: R
authors.lastname: Tumino
authors.forename: Salvatore
authors.initials: S
authors.lastname: Panico
authors.forename: Paolo
authors.initials: P
authors.lastname: Vineis
authors.forename: H Bas
authors.initials: HB
authors.lastname: Bueno-de-Mesquita
authors.forename: Petra H M
authors.initials: PH
authors.lastname: Peeters
authors.forename: Evelyn
authors.initials: E
authors.lastname: Monninkhof
authors.forename: Göran
authors.initials: G
authors.lastname: Berglund
authors.forename: Jonas
authors.initials: J
authors.lastname: Manjer
authors.forename: Pietro
authors.initials: P
authors.lastname: Ferrari
authors.forename: Nadia
authors.initials: N
authors.lastname: Slimani
authors.forename: Rudolf
authors.initials: R
authors.lastname: Kaaks
authors.forename: Elio
authors.initials: E
authors.lastname: Riboli
mesh_terms: D015992:Body Mass Index; D003110:Colonic Neoplasms / Q000453:epidemiology / Q000209:etiology*; D002149:Energy Intake; D005060:Europe / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009043:Motor Activity; D052756:Nutritional Sciences; D011446:Prospective Studies; D012004:Rectal Neoplasms / Q000453:epidemiology / Q000209:etiology*; D012307:Risk Factors