Macroporous hydrogels based on 2-hydroxyethyl methacrylate. Part 5: hydrolytically degradable materials.
Macroporous hydrogels based on 2-hydroxyethyl methacrylate, 2-ethoxyethyl methacrylate and N-(2-hydroxypropyl)methacrylamide, methacrylic acid and [2-(methacryloyloxy)ethyl]trimethylammonium chloride crosslinked with N,O-dimethacryloylhydroxylamine were prepared. Hydrogels were degraded in a buffer of pH 7.4. Completely water-soluble polymers were obtained over time periods ranging from 2 to 40 days. The process of degradation was followed gravimetrically and by optical and electron microscopy. In vivo biological tests with hydrogels based on copolymers of 2-ethoxyethyl methacrylate/N-(2-hydroxypropyl)methacrylamide were performed.
Prádný
Martin
M
Academy of Sciences of the Czech Republic, Institute of Macromolecular Chemistry, 16206, Prague 6, Czech Republic. pradny@imc.cas.cz
Michálek
Jirí
J
Lesný
Petr
P
Hejcl
Ales
A
Vacík
Jirí
J
Slouf
Miroslav
M
Syková
Eva
E
D020341:Absorbable Implants; D000818:Animals; D001672:Biocompatible Materials / Q000378:metabolism* / Q000627:therapeutic use; D005260:Female; D020100:Hydrogels / Q000378:metabolism* / Q000627:therapeutic use; D006868:Hydrolysis; D008422:Materials Testing / Q000379:methods; D008689:Methacrylates / Q000378:metabolism* / Q000627:therapeutic use; D016062:Porosity; D051381:Rats; D017208:Rats, Wistar; D013118:Spinal Cord Diseases / Q000473:pathology / Q000628:therapy
D001672:Biocompatible Materials; D020100:Hydrogels; D008689:Methacrylates; C005044:hydroxyethyl methacrylate