title: Asymmetric bioreductions of beta-nitro acrylates as a route to chiral beta2-amino acids.
abstract: [Structure: see text] Reductions of beta-nitroacrylates by Saccharomyces carlsbergensis old yellow enzyme is the key step in a concise route to optically active beta2-amino acids. The enzymatic reductions occur with 87-96% ee, with larger substrates providing greater stereoselectivities. This work extends enantioselective enzymatic alkene reductions to include acyclic systems with weakly coordinating substituents.
authors.affiliation: Department of Chemistry, University of Florida, Gainesville, Florida 32611, USA.
authors.forename: Magdalena A
authors.initials: MA
authors.lastname: Swiderska
authors.forename: Jon D
authors.initials: JD
authors.lastname: Stewart
mesh_terms: D000179:Acrylates / Q000737:chemistry*; D000596:Amino Acids / Q000737:chemistry*; D010084:Oxidation-Reduction
chemical_list: D000179:Acrylates; D000596:Amino Acids; C036658:acrylic acid