title: Hyperoxia attenuates endothelial-mediated vasodilation in the human skin.
abstract: The influence of hyperoxia on the cutaneous vasodilator responses to iontophoretic applications of acetylcholine (ACh) and sodium nitroprusside (SNP) was examined in healthy subjects. The breathing of 100% O(2) decreased (P < 0.05) the vasodilator response to Ach, but not to SNP, suggesting that hyperoxia attenuates endothelial-mediated vasodilation of the human skin.
authors.affiliation: Department of Clinical Pathophysiology, School of Health Sciences, University of Occupational and Environmental Health, Kitakyushu, 807-8555 Japan. yamazaki@health.uoeh-u.ac.jp
authors.forename: Fumio
authors.initials: F
authors.lastname: Yamazaki
mesh_terms: D000109:Acetylcholine / Q000008:administration & dosage; D000279:Administration, Cutaneous; D000328:Adult; D001783:Blood Flow Velocity; D004730:Endothelium, Vascular / Q000503:physiopathology*; D006801:Humans; D018496:Hyperoxia / Q000503:physiopathology*; D007478:Iontophoresis; D017078:Laser-Doppler Flowmetry; D008297:Male; D008833:Microcirculation; D009599:Nitroprusside / Q000008:administration & dosage; D012867:Skin / Q000098:blood supply*; D013997:Time Factors; D014664:Vasodilation / Q000187:drug effects; D014665:Vasodilator Agents / Q000008:administration & dosage
chemical_list: D014665:Vasodilator Agents; D009599:Nitroprusside; D000109:Acetylcholine