title: Gastrointestinal perforation in very low-birthweight infants.
abstract: BACKGROUND
  Spontaneous isolated gastrointestinal perforation (SIP) in very low-birthweight infants has been reported as a different disease entity from necrotizing enterocolitis (NEC). The objective of this study was to investigate the incidence and risk factors of NEC and SIP.
  
  
  METHODS
  The authors reviewed the medical records of very low-birthweight infants who were admitted to Toho University Perinatal Center, Tokyo, Japan, between 1 January 1991 and 31 December 2002. The diagnosis of NEC was made with the finding of bloody gastric fluid or stool, abdominal distention, and abnormal abdominal X-ray findings such as pneumatosis intestinalis or fixed dilated intestinal loops. SIP was defined at laparotomy as the presence of an isolated gastrointestinal perforation surrounded by normal appearing bowel.
  
  
  RESULTS
  A total of 556 very low-birthweight infants were included in this study. Of those, 15 infants were excluded because of major anomalies. Out of 541 infants, 14 were diagnosed to have NEC or gastrointestinal perforation. In total, 13 infants had gastrointestinal perforation and 10 were confirmed as SIP. Two SIP suggestive cases were included in SIP cases. There was only one case of NEC (0.2%) during 12 years in the authors' institute. Eight SIP cases had antenatal nonsteroidal anti-inflammatory drugs (NSAID). The treatment with antenatal NSAID was significantly associated with the incidence of SIP (p<0.001).
  
  
  CONCLUSIONS
  The authors experienced only one proven case of NEC (0.2%), 12 cases of SIP (2.2%) among 556 very low-birthweight infants admitted during 12 years. Antenatal NSAID were strongly associated with SIP.
authors.affiliation: Department of Neonatology, Toho University School of Medicine, Tokyo, Japan. kawyas@air.linkclub.or.jp
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Kawase
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Ishii
authors.forename: Hiroko
authors.initials: H
authors.lastname: Arai
authors.forename: Naoki
authors.initials: N
authors.lastname: Uga
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects; D003937:Diagnosis, Differential; D020345:Enterocolitis, Necrotizing / Q000175:diagnosis / Q000209:etiology; D005260:Female; D006801:Humans; D015994:Incidence; D007213:Indomethacin / Q000009:adverse effects; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000175:diagnosis* / Q000453:epidemiology / Q000209:etiology / Q000601:surgery; D019102:Infant, Very Low Birth Weight; D007416:Intestinal Perforation / Q000175:diagnosis* / Q000453:epidemiology / Q000209:etiology / Q000601:surgery; D007564:Japan / Q000453:epidemiology; D008297:Male; D008499:Medical Records; D011247:Pregnancy; D012189:Retrospective Studies; D012307:Risk Factors; D013275:Stomach Rupture / Q000175:diagnosis* / Q000453:epidemiology / Q000209:etiology / Q000601:surgery
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D007213:Indomethacin