title: Children's intellectual function in relation to arsenic exposure.
abstract: BACKGROUND
  Very little evidence exists concerning the possible impairment of children's intellectual function in relation to arsenic exposure in utero and during childhood.
  
  
  METHODS
  We conducted a cross-sectional study among 351 children age 5 to 15 years who were selected from a source population of 7683 people in West Bengal, India, in 2001-2003. Intellectual function was assessed with 6 subtests from the Wechsler Intelligence Scale for Children as well as with the Total Sentence Recall test, the Colored Progressive Matrices test, and a pegboard test. Arsenic in urine and lifetime water sources (including during the pregnancy period) were assessed using measurements of samples from 409 wells. The test scores were analyzed with linear regression analyses based on the method of generalized estimating equations incorporating relevant covariates.
  
  
  RESULTS
  Stratifying urinary arsenic concentrations into tertiles, we found associations between arsenic and reductions in the adjusted scores of the vocabulary test (0, -0.14, -0.28; P for trend = 0.02), the object assembly test (0, -0.16, -0.24; P for trend = 0.03), and the picture completion test (0, -0.15, -0.26; P for trend = 0.02). These findings correspond to relative declines of 12% (95% confidence interval =0.4% to 24%) in the vocabulary test, 21% (-0.8% to 42%) in the object assembly test, and of 13% (0.3% to 24%) in the picture completion test in the upper urinary arsenic tertile. However, we did not find evidence of an association between test results and arsenic water concentrations during pregnancy or childhood.
  
  
  CONCLUSIONS
  Current arsenic concentrations in urine, which reflect all sources of recent exposure, including water and food, were associated with small decrements in intellectual testing in school-aged children in West Bengal. We did not see associations between long-term water arsenic concentrations and intellectual function.
authors.affiliation: School of Public Health, University of California, Berkeley, California 94720-7360, USA.
authors.forename: Ondine S
authors.initials: OS
authors.lastname: von Ehrenstein
authors.forename: Shalini
authors.initials: S
authors.lastname: Poddar
authors.forename: Yan
authors.initials: Y
authors.lastname: Yuan
authors.forename: Debendra Guha
authors.initials: DG
authors.lastname: Mazumder
authors.forename: Brenda
authors.initials: B
authors.lastname: Eskenazi
authors.forename: Arin
authors.initials: A
authors.lastname: Basu
authors.forename: Meera
authors.initials: M
authors.lastname: Hira-Smith
authors.forename: Nalima
authors.initials: N
authors.lastname: Ghosh
authors.forename: Sabari
authors.initials: S
authors.lastname: Lahiri
authors.forename: Reina
authors.initials: R
authors.lastname: Haque
authors.forename: Alakendu
authors.initials: A
authors.lastname: Ghosh
authors.forename: Dave
authors.initials: D
authors.lastname: Kalman
authors.forename: Subankar
authors.initials: S
authors.lastname: Das
authors.forename: Allan H
authors.initials: AH
authors.lastname: Smith
mesh_terms: D000293:Adolescent; D001151:Arsenic / Q000737:chemistry / Q000633:toxicity* / Q000652:urine; D020261:Arsenic Poisoning / Q000453:epidemiology*; D002648:Child; D002675:Child, Preschool; D003072:Cognition Disorders / Q000453:epidemiology* / Q000209:etiology; D003430:Cross-Sectional Studies; D004781:Environmental Exposure; D004784:Environmental Monitoring / Q000379:methods; D062665:Epidemiological Monitoring; D005076:Exanthema / Q000453:epidemiology / Q000209:etiology; D005260:Female; D047109:Fetal Development / Q000502:physiology*; D006801:Humans; D007194:India / Q000453:epidemiology; D007361:Intelligence Tests / Q000706:statistics & numerical data; D008297:Male; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D014874:Water Pollutants, Chemical / Q000009:adverse effects* / Q000032:analysis; D014881:Water Supply / Q000032:analysis
chemical_list: D014874:Water Pollutants, Chemical; D001151:Arsenic