title: A fast online hit verification method for the single ion hit system at GSI.
abstract: For a single ion hit facility built to irradiate specific targets inside biological cells, it is necessary to prove that the ions hit the selected targets reliably because the ion hits usually cannot be seen. That ability is traditionally tested either indirectly by aiming at pre-etched tracks in a nuclear track detector or directly by making the ion tracks inside cells visible using a stain coupled to special proteins produced in response to ion hits. However, both methods are time consuming and hits can be verified only after the experiment. This means that targeting errors in the experiment cannot be corrected during the experiment. Therefore, we have developed a fast online hit verification method that measures the targeting accuracy electronically with a spatial resolution of +/-1 microm before cell irradiation takes place.
authors.affiliation: Gesellschaft für Schwerionenforschung GSI, Planckstrasse 1, 64291 Darmstadt, Germany. G.Du@gsi.de
authors.forename: G
authors.initials: G
authors.lastname: Du
authors.forename: B
authors.initials: B
authors.lastname: Fischer
authors.forename: P
authors.initials: P
authors.lastname: Barberet
authors.forename: M
authors.initials: M
authors.lastname: Heiss
mesh_terms: D018929:Cell Culture Techniques / Q000295:instrumentation* / Q000379:methods; D002469:Cell Separation / Q000295:instrumentation* / Q000379:methods; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005858:Germany; D020450:Heavy Ions; D007090:Image Interpretation, Computer-Assisted / Q000295:instrumentation / Q000379:methods*; D007477:Ions; D008853:Microscopy / Q000295:instrumentation* / Q000379:methods; D008904:Miniaturization; D009862:Online Systems; D010315:Particle Accelerators / Q000295:instrumentation*; D011829:Radiation Dosage; D011874:Radiometry / Q000295:instrumentation* / Q000379:methods; D012680:Sensitivity and Specificity; D013673:Technology Assessment, Biomedical
chemical_list: D007477:Ions