title: Topological stabilization of PNA-DNA invasion complex.
abstract: We propose the concept of a PNA-DNA (PD) padlock exploiting a topological link between PNA and DNA. We synthesized padlock-forming PNAs and demonstrated the validity of this concept by gel shift assay. We also suggest a design principle for padlock-forming PNA.
authors.affiliation: Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Komaba, Meguro-ku, Tokyo 153-8902, Japan.
authors.forename: Toru
authors.initials: T
authors.lastname: Sugiyama
authors.forename: Reiko
authors.initials: R
authors.lastname: Kuroda
authors.forename: Atsushi
authors.initials: A
authors.lastname: Kittaka
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D004247:DNA / Q000737:chemistry* / Q000235:genetics; D024202:Electrophoretic Mobility Shift Assay; D008969:Molecular Sequence Data; D009692:Nucleic Acid Heteroduplexes / Q000737:chemistry*; D020135:Peptide Nucleic Acids / Q000737:chemistry*; D013816:Thermodynamics
chemical_list: D009692:Nucleic Acid Heteroduplexes; D020135:Peptide Nucleic Acids; D004247:DNA