title: Central obesity is associated with nonatopic but not atopic asthma in a representative population sample.
abstract: BACKGROUND
  Epidemiologic studies have consistently demonstrated the association between high body mass index (BMI) and asthma, yet the relationship between asthma and the alternative central obesity phenotypes, waist circumference (WC) and waist-to-hip ratio (WHR), has not been assessed in a representative population sample.
  
  
  OBJECTIVE
  To determine the strength of the association of WC and WHR with current asthma and whether the association is modified by atopic status in a representative population sample.
  
  
  METHODS
  The North West Adelaide Health Study, a biomedical population study of n = 4060, assessed current asthma, respiratory symptoms, and participant demographics by self-completed questionnaire. Clinic assessment included measures of WC and WHR, spirometry, and skin prick tests to a panel of allergens.
  
  
  RESULTS
  Logistic regression analysis showed a significant, marginal increased adjusted risk of asthma associated with obese levels of WC and WHR and BMI > or =35.0 kg/m2 in female subjects only. When the association was considered stratified according to atopic status, the relationship between obese levels of WC and WHR with asthma held only for the nonatopic population in both males (WC: odds ratio [OR] 5.7, 95% confidence interval [CI] 1.1-28.8; WHR: OR 6.2, 95% CI, 1.1-32.9) and females (WC: OR 2.3, 95% CI, 1.2-4.4; WHR: OR 3.0, 95% CI, 1.5-5.9). BMI > or =35.0 kg/m2 showed an inconsistent pattern in the association with asthma.
  
  
  CONCLUSIONS
  Central obesity was significantly associated with an increased risk of nonatopic asthma only. The causal pathway is unknown, but this study suggests the involvement of different pathophysiological mechanisms requiring further investigation.
  
  
  CONCLUSIONS
  Asthma should be considered in older, nonatopic, centrally obese, symptomatic individuals.
authors.affiliation: Health Observatory, Department of Medicine, University of Adelaide, Queen Elizabeth Hospital Campus, Woodville, South Australia, Australia.
authors.forename: Sarah L
authors.initials: SL
authors.lastname: Appleton
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Adams
authors.forename: David H
authors.initials: DH
authors.lastname: Wilson
authors.forename: Anne W
authors.initials: AW
authors.lastname: Taylor
authors.forename: Richard E
authors.initials: RE
authors.lastname: Ruffin
mesh_terms: D000293:Adolescent; D000328:Adult; D001249:Asthma / Q000453:epidemiology* / Q000209:etiology; D001315:Australia / Q000453:epidemiology; D015992:Body Mass Index; D005260:Female; D006801:Humans; D008297:Male; D009765:Obesity / Q000150:complications / Q000453:epidemiology* / Q000503:physiopathology; D016017:Odds Ratio; D012044:Regression Analysis; D012307:Risk Factors; D012737:Sex Factors; D011795:Surveys and Questionnaires; D049629:Waist-Hip Ratio