5-Propynylamino alpha-deoxyuridine promotes DNA duplex stabilization of anionic and neutral but not cationic alpha-oligonucleotides.
Incorporation of 5-propynylamino and 5-propynyl alpha-2'-deoxyuridine into alpha-oligonucleotides (alpha-ON) allows high-affinity targeting of complementary DNA for alpha-ON with anionic and neutral backbone but not for cationic alpha-ON, revealing clues on the role of the amino group of the propynylamino on the formation of DNA duplexes.
Deglane
Gaëlle
G
LCOBS, UMR 5625 CNRS-UM II, Université Montpellier II, 34095 Montpellier, France.
Morvan
François
F
Debart
Françoise
F
Vasseur
Jean-Jacques
JJ
D000838:Anions; D002412:Cations; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004247:DNA / Q000737:chemistry* / Q000187:drug effects*; D003857:Deoxyuridine / Q000031:analogs & derivatives* / Q000494:pharmacology; D009691:Nucleic Acid Denaturation; D009841:Oligonucleotides / Q000737:chemistry*; D016376:Oligonucleotides, Antisense / Q000737:chemistry; D014466:Ultraviolet Rays
C518725:5-Propynylamino alpha-deoxyuridine; D000838:Anions; D002412:Cations; D009841:Oligonucleotides; D016376:Oligonucleotides, Antisense; D004247:DNA; D003857:Deoxyuridine