title: [Clinical analysis of yuziwan in the treatment of 30 sterile men with abnormal protamine].
abstract: OBJECTIVE
  To study the clinical application and effects of Yuziwan in the treatment of male sterility patient with abnormal protamine.
  
  
  METHODS
  The changes of protamine, semen and sex hormones of 30 male sterility patients treated by Yuziwan were observed before and after the treatment.
  
  
  RESULTS
  After a 3-month course of treatment, 9 cases were cured, 15 obviously improved and 6 failed to respond. The ratio of histone to protamine was decreased from (1.34 +/- 0.52) before the treatment to (0.72 +/- 0.32) after it, with significant difference (P < 0.01), the semen quality obviously improved (P < 0.05), and the LH and T levels markedly raised (P < 0.01). Yuziwan evidently improved the abnormal protamine, sperm quality and endocrine function of the sterility patients.
  
  
  CONCLUSIONS
  Yuziwan has good curative effect on male sterility.
authors.affiliation: Center of Reproductive Medicine, Cangzhou Hospital of Integrated TMC and Western Medicine, Cangzhou, Hebei 061001, China. yixiangzhai@sina.com
authors.forename: Xu-chu
authors.initials: XC
authors.lastname: Wang
authors.forename: Hai-song
authors.initials: HS
authors.lastname: Li
authors.forename: Tian-ming
authors.initials: TM
authors.lastname: Pan
mesh_terms: D000328:Adult; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D006657:Histones / Q000378:metabolism; D006801:Humans; D007248:Infertility, Male / Q000188:drug therapy* / Q000378:metabolism; D008297:Male; D008517:Phytotherapy; D011479:Protamines / Q000378:metabolism
chemical_list: D004365:Drugs, Chinese Herbal; D006657:Histones; D011479:Protamines