Wnt lipid modifications: not as saturated as we thought.
In this issue of Developmental Cell, Takada et al. (2006) describe a novel lipid modification in Wnt3a. This exciting finding may prove pivotal in our attempts to decipher the mechanisms underlying Wnt secretion.
Hausmann
George
G
Institut fur Molekularbiologie, Universitat Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland.
Basler
Konrad
K
D000215:Acylation; D000818:Animals; D005229:Fatty Acids, Monounsaturated / Q000378:metabolism*; D011499:Protein Processing, Post-Translational; D021381:Protein Transport; D051153:Wnt Proteins / Q000235:genetics / Q000378:metabolism*; D014982:Xenopus laevis / Q000196:embryology / Q000235:genetics / Q000378:metabolism*
D005229:Fatty Acids, Monounsaturated; D051153:Wnt Proteins; C008757:palmitoleic acid