Sensitivity comparison of multiple vs. single inversion time pulsed arterial spin labeling fMRI.
OBJECTIVE
To study the sensitivity for detection of activation for multiple vs. single inversion time (TI) pulsed arterial spin labeling (PASL).


METHODS
The number of activated voxels and the mean t-statistic over activated voxels was measured by means of multiple and single TI PASL sequences in five volunteers during visual stimulation by means of an alternating checkerboard. Acquisition was performed by means of the transfer insensitive labeling technique (TILT) and TURBO-TILT.


RESULTS
It was found that the sensitivity for the detection of activation was lower for an individual TI out of a multiple TI sequence than for the corresponding single TI acquisition of equal duration. After averaging over all TIs between and including 600 and 1400 msec, the number of activated voxels and mean t-statistic were no longer statistically lower for the multiple TI sequence than for the single TI experiment.


CONCLUSIONS
Multiple TI PASL can be used for functional MRI (fMRI) studies, when performing the detection of activated brain regions on data that is averaged over all TIs between 600 and 1400 msec. Subsequently the multi-TI data can be used to quantify cerebral blood flow (CBF) changes upon activation. Additionally, we have shown that single TI PASL fMRI overestimates the CBF changes upon activation due to transit time changes.
van Osch
Matthias J P
MJ
Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands. M.J.P.van_Osch@lumc.nl
Hendrikse
Jeroen
J
van der Grond
Jeroen
J
D000328:Adult; D001931:Brain Mapping / Q000379:methods*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008962:Models, Theoretical; D010775:Photic Stimulation; D012680:Sensitivity and Specificity; D013113:Spin Labels
D013113:Spin Labels