title: Inhibition of hepatitis C IRES-mediated gene expression by small hairpin RNAs in human hepatocytes and mice.
abstract: The ability of small hairpin RNAs (shRNAs) to inhibit hepatitis C virus internal ribosome entry site (HCV IRES)-dependent gene expression was investigated in cultured cells and a mouse model. The results indicate that shRNAs, delivered as naked RNA or expressed from vectors, may be effective agents for the control of HCV and related viruses.
authors.affiliation: SomaGenics, Inc., Santa Cruz, CA 95060, USA.
authors.forename: Heini
authors.initials: H
authors.lastname: Ilves
authors.forename: Roger L
authors.initials: RL
authors.lastname: Kaspar
authors.forename: Qian
authors.initials: Q
authors.lastname: Wang
authors.forename: Attila A
authors.initials: AA
authors.lastname: Seyhan
authors.forename: Alexander V
authors.initials: AV
authors.lastname: Vlassov
authors.forename: Christopher H
authors.initials: CH
authors.lastname: Contag
authors.forename: Devin
authors.initials: D
authors.lastname: Leake
authors.forename: Brian H
authors.initials: BH
authors.lastname: Johnston
mesh_terms: D000818:Animals; D000998:Antiviral Agents; D002478:Cells, Cultured; D015870:Gene Expression; D015316:Genetic Therapy; D006526:Hepatitis C / Q000235:genetics / Q000628:therapy*; D022781:Hepatocytes; D006801:Humans; D051379:Mice; D034741:RNA, Small Interfering / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D000998:Antiviral Agents; D034741:RNA, Small Interfering