[Relevance of some growth factors to cardiovascular disease in maintenance hemodialysis patients].
Hepatocyte growth factor, activin A and follistatin compose an intricate, pleiotropic and mostly antagonistic cytokine network. They have a crucial impact on the cardiovascular system, including the development of atherosclerosis and its ischemic complications. We reviewed the significance of the above growth factors in maintenance hemodialysis patients, and stressed their likely causative role in the acceleration of cardiovascular disease progression. Recent clinical trials showing marked activation of the growth factors by heparin administered during hemodialysis procedures also were discussed, including the distinct effects of unfractionated heparin vs low-molecular-weight heparin enoxaparin.
Borawski
Jacek
J
Akademia Medyczna w Białymstoku, Klinika Nefrologii i Transplantologii z Ośrodkiem Dializ.
Myśliwiec
Michał
M
D028341:Activins / Q000097:blood / Q000378:metabolism*; D015415:Biomarkers; D002318:Cardiovascular Diseases / Q000209:etiology* / Q000378:metabolism* / Q000401:mortality; D018450:Disease Progression; D038681:Follistatin / Q000097:blood / Q000378:metabolism*; D006493:Heparin / Q000009:adverse effects / Q000145:classification; D017228:Hepatocyte Growth Factor / Q000097:blood / Q000378:metabolism*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications / Q000378:metabolism / Q000401:mortality / Q000628:therapy*; D006435:Renal Dialysis / Q000009:adverse effects*
D015415:Biomarkers; D038681:Follistatin; D028341:Activins; D017228:Hepatocyte Growth Factor; D006493:Heparin