title: Ketanserin accelerates wound epithelialization and neovascularization.
abstract: We investigated the acute effects of topical ketanserin, a 5-HT(2) (serotonin) receptor blocker, on wound epithelialization and vascularization with the use of the hairless mouse ear model. Varying concentrations of Ketanserin (0%, 0.2%, 2.0%, 20% weight/volume) were administered to standardized full-thickness skin wounds on the dorsum of the hairless mouse ear immediately after surgery and daily thereafter. With the use of video microscopy and computer-assisted planimetry, vascularization and epithelialization were traced every third day until the wounds were fully healed. Arteriole diameters at selected sites near the skin wound were measured before wound creation and after wounding. It was concluded that topically administered ketanserin significantly accelerates both the vascular (p < 0.001 at 2% and 20% concentrations) and epithelial (p < 0.001 at 20% concentration) rates of wound healing in full-thickness nonpathologic skin wounds. Vasodilation of terminal arterioles was not a major response to Ketanserin. Faster epithelialization was possibly due to direct effect of ketanserin on epithelial cells.
authors.affiliation: Division of Plastic and Reconstructive Surgery and Center for Microcirculatory Studies, University of Louisville, KY 40292, USA.
authors.forename: M
authors.initials: M
authors.lastname: Kim
authors.forename: E T
authors.initials: ET
authors.lastname: Ustüner
authors.forename: D
authors.initials: D
authors.lastname: Schuschke
authors.forename: A
authors.initials: A
authors.lastname: Morsing
authors.forename: D
authors.initials: D
authors.lastname: Kjolseth
authors.forename: V
authors.initials: V
authors.lastname: Fingar
authors.forename: J
authors.initials: J
authors.lastname: Wieman
authors.forename: M
authors.initials: M
authors.lastname: Kamler
authors.forename: G R
authors.initials: GR
authors.lastname: Tobin
authors.forename: S
authors.initials: S
authors.lastname: Bond
authors.forename: J H
authors.initials: JH
authors.lastname: Barker