title: [Synactones--functionally conjugated complexes of endogenous regulators].
abstract: All physiological processes are regulated by complexes of various endogenous compounds (EC), acting in definite sequences and combinations. The effort to model the regulation by introducing separate ECs provides only partial information. This circumstance also limits the therapeutic efficiency of separate ECs and their stabilized derivatives. Therefore, it is obviously necessary to extensively investigate various EC complexes, for which a conventional name of "synactones" is proposed. It is expedient to use this name only for conjugated EC (or their stabilized derivatives) rather than to various drug combinations with compositions and structures far from those of the endogenous regulators of animal organism. Examples of the most promising synactones (in the form of mixtures of ECs or covalently associated ECs) are presented. Specific methodological difficulties of such investigations, as well as the problems related to various ways of administration and blood-brain barrier penetration are considered.
authors.forename: I P
authors.initials: IP
authors.lastname: Ashmarin
authors.forename: S V
authors.initials: SV
authors.lastname: Koroleva
authors.forename: N F
authors.initials: NF
authors.lastname: Miasoedov
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001812:Blood-Brain Barrier / Q000378:metabolism*; D015195:Drug Design; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000737:chemistry* / Q000493:pharmacokinetics*; D008969:Molecular Sequence Data
chemical_list: D036341:Intercellular Signaling Peptides and Proteins