[Effects of cell-binding protein A of Staphylococcus aureus on the level of intracellular calcium ions and actomyosin ATP-ase activity in the smooth muscles].
Immune-active substance of Staphylococcus aureus, cell-bound protein A (CBPA), enhances the acetylcholine- or hyperpotassium (K+) Krebs solution-evoked excitation in Taenia coli smooth muscles. CBPA increases caffeine- and carbachole-evoked Ca2+ signals in smooth muscle cells suspension, loaded with indo-1, and also caffeine- and acetylcholine-evoked contraction in smooth muscles slices. Against a background of CBPA-suppressed action of sodium nitroprusside, ATP evokes the membrane depolarization. CBPA in small concentrations potentiates ATPase (Mg2+,Ca2+-; Mg2+- and Mg2+- in the presence of EGTA) activity of actomyosin in the smooth muscles.
Melenevs'ka
N V
NV
Miroshnychenko
M S
MS
Filippov
I B
IB
Artemenko
O Iu
OIu
Shuba
M F
MF
D000109:Acetylcholine / Q000494:pharmacology; D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D002110:Caffeine / Q000494:pharmacology; D020013:Calcium Signaling / Q000187:drug effects*; D002217:Carbachol / Q000494:pharmacology; D002478:Cells, Cultured; D003106:Colon / Q000166:cytology / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D006168:Guinea Pigs; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000166:cytology / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D009218:Myosins / Q000378:metabolism*; D009599:Nitroprusside / Q000494:pharmacology; D013205:Staphylococcal Protein A / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000378:metabolism*
D013205:Staphylococcal Protein A; D009599:Nitroprusside; D002110:Caffeine; D002217:Carbachol; D009218:Myosins; D000109:Acetylcholine