title: Detection of a single DNA base-pair mismatch using an anthracene-tagged fluorescent probe.
abstract: A novel anthracene-tagged oligonucleotide can discriminate between a fully-matched DNA target sequence and one with a single mismatching base-pair through a remarkable difference in fluorescence emission intensity upon duplex formation.
authors.affiliation: School of Chemistry, University of Birmingham, Edgbaston, Birmingham, UK.
authors.forename: Nina
authors.initials: N
authors.lastname: Moran
authors.forename: Dario M
authors.initials: DM
authors.lastname: Bassani
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Desvergne
authors.forename: Sonja
authors.initials: S
authors.lastname: Keiper
authors.forename: Philip A S
authors.initials: PA
authors.lastname: Lowden
authors.forename: Joseph S
authors.initials: JS
authors.lastname: Vyle
authors.forename: James H R
authors.initials: JH
authors.lastname: Tucker
mesh_terms: D000873:Anthracenes / Q000737:chemistry*; D020137:Base Pair Mismatch / Q000235:genetics*; D004247:DNA / Q000737:chemistry / Q000235:genetics*; D005456:Fluorescent Dyes / Q000138:chemical synthesis / Q000737:chemistry*; D015394:Molecular Structure; D015345:Oligonucleotide Probes / Q000138:chemical synthesis / Q000737:chemistry*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D013050:Spectrometry, Fluorescence; D013237:Stereoisomerism
chemical_list: D000873:Anthracenes; D005456:Fluorescent Dyes; D015345:Oligonucleotide Probes; D004247:DNA