title: ADP_EM: fast exhaustive multi-resolution docking for high-throughput coverage.
abstract: BACKGROUND
  Efficient fitting tools are needed to take advantage of a fast growth of atomic models of protein domains from crystallography or comparative modeling, and low-resolution density maps of larger molecular assemblies. Here, we report a novel fitting algorithm for the exhaustive and fast overlay of partial high-resolution models into a low-resolution density map. The method incorporates a fast rotational search based on spherical harmonics (SH) combined with a simple translational scanning.
  
  
  RESULTS
  This novel combination makes it possible to accurately dock atomic structures into low-resolution electron-density maps in times ranging from seconds to a few minutes. The high-efficiency achieved with simulated and experimental test cases preserves the exhaustiveness needed in these heterogeneous-resolution merging tools. The results demonstrate its efficiency, robustness and high-throughput coverage.
  
  
  BACKGROUND
  http://sbg.cib.csic.es/Software/ADP_EM.
  
  
  BACKGROUND
  Supplementary data are available at Bioinformatics online.
authors.affiliation: Centro de Investigaciones Biológicas, CSIC Ramiro de Maeztu 9, 28040 Madrid, Spain.
authors.forename: José Ignacio
authors.initials: JI
authors.lastname: Garzón
authors.forename: Julio
authors.initials: J
authors.lastname: Kovacs
authors.forename: Ruben
authors.initials: R
authors.lastname: Abagyan
authors.forename: Pablo
authors.initials: P
authors.lastname: Chacón
mesh_terms: D000465:Algorithms; D001665:Binding Sites; D003198:Computer Simulation; D008956:Models, Chemical; D008958:Models, Molecular; D011485:Protein Binding; D011487:Protein Conformation; D025941:Protein Interaction Mapping / Q000379:methods*; D011506:Proteins / Q000737:chemistry* / Q000648:ultrastructure*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D020539:Sequence Analysis, Protein / Q000379:methods*
chemical_list: D011506:Proteins