title: Tissue distribution of the antigenic variants of canine parvovirus type 2 in dogs.
abstract: Twelve dogs dead as consequence of natural infection caused by canine parvovirus (CPV) type 2a (n=4), type 2b (n=4) or type 2c (n=4) were investigated for determining the viral DNA loads in different tissue samples. By means of a real-time PCR assay, CPV DNA was detected in all tissues examined, with the highest titres observed in the lymphoid tissue and the lowest loads in the urinary tract. Surprisingly, the nervous tissue was found to contain considerable amounts of CPV nucleic acid. Similar patterns of tissue distribution were observed in all the examined dogs irrespective of the antigenic variant causing the disease.
authors.affiliation: Department of Animal Health and Well-being, Faculty of Veterinary Medicine of Bari, Strada per Casamassima Km 3, 70010 Valenzano, Bari, Italy. n.decaro@veterinaria.uniba.it
authors.forename: Nicola
authors.initials: N
authors.lastname: Decaro
authors.forename: Vito
authors.initials: V
authors.lastname: Martella
authors.forename: Gabriella
authors.initials: G
authors.lastname: Elia
authors.forename: Costantina
authors.initials: C
authors.lastname: Desario
authors.forename: Marco
authors.initials: M
authors.lastname: Campolo
authors.forename: Eleonora
authors.initials: E
authors.lastname: Lorusso
authors.forename: Maria Loredana
authors.initials: ML
authors.lastname: Colaianni
authors.forename: Alessio
authors.initials: A
authors.lastname: Lorusso
authors.forename: Canio
authors.initials: C
authors.lastname: Buonavoglia
mesh_terms: D000818:Animals; D000940:Antigenic Variation / Q000502:physiology*; D004279:DNA, Viral / Q000737:chemistry / Q000235:genetics; D004283:Dog Diseases / Q000821:virology*; D004285:Dogs; D008221:Lymphoid Tissue / Q000821:virology; D010322:Parvoviridae Infections / Q000821:virology*; D017993:Parvovirus, Canine / Q000235:genetics / Q000254:growth & development / Q000276:immunology*; D016133:Polymerase Chain Reaction / Q000662:veterinary; D019562:Viral Load / Q000662:veterinary
chemical_list: D004279:DNA, Viral