title: Increased stress and smaller anterior hippocampal volume.
abstract: Animal studies indicate that stress negatively impacts hippocampal structure; little is known, however, regarding the relationship between stress and hippocampal morphology in healthy humans. Twenty-one healthy adults underwent structural magnetic resonance imaging examinations and completed the Derogatis Stress Profile. Greater psychological stress at the time of the scan correlated significantly and more strongly with anterior than posterior hippocampal volume. These findings suggest that psychological stress may be associated with structural alterations in the anterior hippocampal formation and that this relationship may differ along the rostrocaudal axis of the hippocampus. Our results may also have implications for neuropsychiatric disorders that have implicated stress and hippocampal abnormalities in their pathogenesis.
authors.affiliation: Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore-Long Island Jewish Health System, Glen Oaks, New York 11004, USA. szeszko@lij.edu
authors.forename: Philip R
authors.initials: PR
authors.lastname: Szeszko
authors.forename: Julia D
authors.initials: JD
authors.lastname: Betensky
authors.forename: Claudia
authors.initials: C
authors.lastname: Mentschel
authors.forename: Handan
authors.initials: H
authors.lastname: Gunduz-Bruce
authors.forename: Todd
authors.initials: T
authors.lastname: Lencz
authors.forename: Manzar
authors.initials: M
authors.lastname: Ashtari
authors.forename: Anil K
authors.initials: AK
authors.lastname: Malhotra
authors.forename: Robert M
authors.initials: RM
authors.lastname: Bilder
mesh_terms: D000328:Adult; D001931:Brain Mapping; D005260:Female; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D009483:Neuropsychological Tests; D013315:Stress, Psychological / Q000473:pathology*