title: Second hand smoke exposure and survival in early-stage non-small-cell lung cancer patients.
abstract: OBJECTIVE
  Second hand smoke (SHS) exposure is associated with higher risk of lung cancer. However, the role of SHS in lung cancer survival is not clear.
  
  
  METHODS
  We examined the association between self-reported SHS exposure before diagnosis and overall survival and recurrence-free survival in 393 early-stage non-small-cell lung cancer patients. SHS exposure was analyzed by both duration and location of exposure using log-rank test and Cox proportional hazard models, adjusting for covariates including pack-years of smoking.
  
  
  RESULTS
  The median follow-up time was 66 months (range, 0.2-140 months). There were 135 recurrences and 213 deaths. The 5-year overall survival rates were 71% [95% confidence interval (95% CI), 62-81%], 61% (51-72%), 49% (38-60%), and 47% (37-58%), respectively, for patients with the lowest to highest quartile of SHS exposure durations (P < 0.001, log-rank test), with the adjusted hazard ratio (AHR) of 1.57 (95% CI, 1.02-2.41) for the highest versus lowest quartile of SHS exposure durations (P(trend) = 0.04). For different SHS exposure locations, a stronger association was found for SHS exposure at work (AHR of the highest versus lowest quartile, 1.71; 95% CI, 1.12-2.61; P(trend) = 0.03) than for exposure at home (AHR, 1.26; 95% CI, 0.86-1.86; P(trend) = 0.20) or leisure places (AHR, 1.28; 95% CI, 0.83-1.95; P(trend) = 0.16). Similar associations were observed when SHS exposure durations were dichotomized into two or three groups and between SHS exposure and recurrence-free survival.
  
  
  CONCLUSIONS
  SHS exposure is associated with worse survival in early-stage non-small-cell lung cancer patients, especially for SHS exposure at the work.
authors.affiliation: Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA. wzhou@hsph.harvard.edu
authors.forename: Wei
authors.initials: W
authors.lastname: Zhou
authors.forename: Rebecca S
authors.initials: RS
authors.lastname: Heist
authors.forename: Geoffrey
authors.initials: G
authors.lastname: Liu
authors.forename: Kofi
authors.initials: K
authors.lastname: Asomaning
authors.forename: David P
authors.initials: DP
authors.lastname: Miller
authors.forename: Donna S
authors.initials: DS
authors.lastname: Neuberg
authors.forename: John C
authors.initials: JC
authors.lastname: Wain
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Lynch
authors.forename: David C
authors.initials: DC
authors.lastname: Christiani
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002289:Carcinoma, Non-Small-Cell Lung / Q000175:diagnosis* / Q000628:therapy; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011237:Predictive Value of Tests; D015996:Survival Rate; D014028:Tobacco Smoke Pollution / Q000009:adverse effects*; D016896:Treatment Outcome
chemical_list: D014028:Tobacco Smoke Pollution