title: [Perfusion-diffusion 1H spectroscopy: role in the diagnosis and follow-up of supratentorial brain tumours in adults].
abstract: BACKGROUND
  In a few years, magnetic resonance imaging (MRI) has evolved from a morphology-based examination to one that encompasses metabolism and function.
  
  
  BACKGROUND
  MRI is a well-established tool for the initial evaluation of brain tumors, but conventional MR sequences have some limitations. Conventional MRI is unable to distinguish high-grade glioma from metastasis and abscess, to define precisely the histopathological grade of gliomas, to determine exactly the limits of tumor extension, to characterize meningeal tumors. Differentiation of tumor recurrence from treatment-related changes may be difficult with standard MR imaging because the interpretation is essentially based on volume analysis.
  
  
  CONCLUSIONS
  1H Spectroscopy, diffusion and perfusion imaging become possible with the development of MR imagers and can be routinely performed in clinical settings. They give complementary information about tumor metabolism and vascularity and allow a better analysis of post-treatment modifications. Functional and metabolic explorations should be used to characterize brain tumors.
authors.affiliation: Unité IRM, CHU, Grenoble. SGrand@chu-grenoble.fr
authors.forename: S
authors.initials: S
authors.lastname: Grand
authors.forename: S
authors.initials: S
authors.lastname: Kremer
authors.forename: I
authors.initials: I
authors.lastname: Tropres
authors.forename: C
authors.initials: C
authors.lastname: Pasteris
authors.forename: A
authors.initials: A
authors.lastname: Krainik
authors.forename: D
authors.initials: D
authors.lastname: Hoffmann
authors.forename: S
authors.initials: S
authors.lastname: Chabardes
authors.forename: F
authors.initials: F
authors.lastname: Berger
authors.forename: B
authors.initials: B
authors.lastname: Pasquier
authors.forename: V
authors.initials: V
authors.lastname: Lefournier
authors.forename: J F
authors.initials: JF
authors.lastname: Le Bas
mesh_terms: D000328:Adult; D001254:Astrocytoma / Q000175:diagnosis / Q000473:pathology; D005909:Glioblastoma / Q000175:diagnosis / Q000473:pathology; D005910:Glioma / Q000175:diagnosis / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009837:Oligodendroglioma / Q000175:diagnosis / Q000473:pathology; D015173:Supratentorial Neoplasms / Q000175:diagnosis* / Q000473:pathology