Improved performance of a DNA nanomachine by cationic copolymers.
We have reported previously that the cationic comb-type copolymer, PLL-g-Dex, accelerated DNA strand exchange reaction while stabilizing DNA duplexes. In this research, we studied the effects of PLL-g-Dex on a DNA-fueled nanomachine. The copolymer enabled rapid and secure operations of the DNA nanomachine which utilized the structural transition between intramolecular G-quadruplex and intermolecular double helix.
Makita
Naoki
N
Department of Biomolecular Engineering, Graduate School of Biosdence and Biotechnology, Tokyo Institute of Technology.
Inoue
Satoru
S
Akaike
Toshihiro
T
Maruyama
Atsushi
A
D004247:DNA / Q000737:chemistry*; D003911:Dextrans / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*; D011107:Polylysine / Q000737:chemistry*
D003911:Dextrans; D011107:Polylysine; D004247:DNA