title: Slow-release fluoride glass devices: in vivo fluoride release and retention of the devices in children.
abstract: OBJECTIVE
  To study the fluoride release and retention of new-shaped glass slow-release F devices (SRFD) in vivo in children.
  
  
  METHODS
  A group of 15 children had a SRFD with 17.4% or 14.8 mgm F with a relative solubility of 294, attached intra-orally on the buccal surface of one of their maxillary permanent molars. The devices were monitored for six months.
  
  
  RESULTS
  The retention rate of the devices was 93% and the mean salivary F levels in the child volunteers was 01.17+/-0.1 ppm F compared with 0.025 ppm F baseline levels. The difference was statistically significant (p<0.01). There were no systemic or local side effects.
  
  
  CONCLUSIONS
  The devices were well tolerated by children and released fluoride intra-orally for the whole period of six months to a level consistent with inhibition of demineralisation.
authors.affiliation: Departmentof Paediatric Dentistrty, Leeds Dental Institute, Leeds, UK.
authors.forename: G A
authors.initials: GA
authors.lastname: Andreadis
authors.forename: K J
authors.initials: KJ
authors.lastname: Toumba
authors.forename: M E J
authors.initials: ME
authors.lastname: Curzon
mesh_terms: D000293:Adolescent; D002327:Cariostatic Agents / Q000008:administration & dosage* / Q000009:adverse effects; D002648:Child; D003692:Delayed-Action Preparations; D003731:Dental Caries / Q000517:prevention & control*; D016503:Drug Delivery Systems; D005459:Fluorides / Q000008:administration & dosage* / Q000009:adverse effects; D005891:Gingivitis / Q000139:chemically induced; D005898:Glass; D006801:Humans; D008437:Maxilla; D008963:Molar; D010865:Pilot Projects; D012016:Reference Values; D012463:Saliva / Q000187:drug effects*
chemical_list: D002327:Cariostatic Agents; D003692:Delayed-Action Preparations; D005459:Fluorides