title: Pediatric melanoma of the head and neck: a single institutions experience.
abstract: OBJECTIVE
  The objectives of this study were to review our experience with pediatric melanoma of the head and neck and discuss proper diagnostic protocols and suggest a possible treatment algorithm.
  
  
  METHODS
  The authors conducted a retrospective chart review of patients under the age of 18 who underwent treatment for melanoma of the head and neck at a tertiary care university hospital.
  
  
  RESULTS
  Six patients were identified in the last 25 years at our institution. Four patients had melanomas in the auricle, one in the cheek, and one in the forehead. All occurrences identified presented in the past 7 years. All were treated with wide local excision. Three patients received sentinel lymph node biopsy, one received a neck dissection after identification of positive sentinel nodes, and two patients received postoperative interferon therapy. No surgical complications were reported. At the time of this submission, no patients were found to have recurrence of the disease.
  
  
  CONCLUSIONS
  Pediatric melanoma of the head and neck may be managed effectively using current techniques used in treating adult patients. The use of sentinel lymph node biopsy is recommended when the depth of invasion cannot be determined from original biopsy, the original pathologic diagnosis is ambiguous, or depth of invasion from biopsy is sufficient to warrant its use. In addition, the use of adjuvant interferon alpha-2b is recommended in patients at high risk for recurrence.
authors.affiliation: Loma Linda University Children's Hospital, Division of Otolaryngology, Head and Neck Surgery, Loma Linda, California 92354, USA.
authors.forename: James C
authors.initials: JC
authors.lastname: French
authors.forename: Mark R
authors.initials: MR
authors.lastname: Rowe
authors.forename: T J O
authors.initials: TJ
authors.lastname: Lee
authors.forename: Jonathan E
authors.initials: JE
authors.lastname: Zwart
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D005260:Female; D006258:Head and Neck Neoplasms / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000627:therapeutic use; D008297:Male; D008545:Melanoma / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D009361:Neoplasm Invasiveness; D049268:Positron-Emission Tomography; D011994:Recombinant Proteins; D012189:Retrospective Studies; D021701:Sentinel Lymph Node Biopsy
chemical_list: D000970:Antineoplastic Agents; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins