title: Dynamic mapping of hippocampal development in childhood onset schizophrenia.
abstract: Prior cross-sectional anatomic brain imaging studies of the hippocampus in schizophrenia have generally shown loss in total hippocampal volume although the progressive course of these changes remains unknown. We report the first prospective sub-regional maps of hippocampal development in childhood onset schizophrenia (COS), reconstructed from serial brain MRI scans of 29 children with COS scanned every 2 years (87 scans) and compared to 31 controls matched for age, sex, and scan interval (94 scans). As expected, the COS subjects showed significant bilateral deficits (9-10%) in total hippocampal volume which remained consistent between age 9 and 26. However sub-regional maps showed heterogeneous changes with loss of hippocampal volume in both anterior as well as posterior ends while the body of the hippocampus gained in volume suggesting that hippocampal subunits are differentially affected in schizophrenia.
authors.affiliation: Child Psychiatry Branch, NIMH, Bethesda, MD 20892, USA.
authors.forename: Tom F
authors.initials: TF
authors.lastname: Nugent
authors.forename: David H
authors.initials: DH
authors.lastname: Herman
authors.forename: Anna
authors.initials: A
authors.lastname: Ordonez
authors.forename: Deanna
authors.initials: D
authors.lastname: Greenstein
authors.forename: Kiralee M
authors.initials: KM
authors.lastname: Hayashi
authors.forename: Marge
authors.initials: M
authors.lastname: Lenane
authors.forename: Liv
authors.initials: L
authors.lastname: Clasen
authors.forename: David
authors.initials: D
authors.lastname: Jung
authors.forename: Arthur W
authors.initials: AW
authors.lastname: Toga
authors.forename: Jay N
authors.initials: JN
authors.lastname: Giedd
authors.forename: Judith L
authors.initials: JL
authors.lastname: Rapoport
authors.forename: Paul M
authors.initials: PM
authors.lastname: Thompson
authors.forename: Nitin
authors.initials: N
authors.lastname: Gogtay
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D002648:Child; D004292:Dominance, Cerebral / Q000502:physiology; D005260:Female; D006624:Hippocampus / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging; D008297:Male; D011446:Prospective Studies; D012016:Reference Values; D015203:Reproducibility of Results; D012559:Schizophrenia / Q000175:diagnosis / Q000503:physiopathology*