title: [A case of multiple sclerosing hemangiomas of both lungs].
abstract: A 16-year-old Chinese girl was found to have abnormalities on chest roentgenography at a school health checkup in 2004, and she visited our outpatient clinic for the first time on July 2. Based on the imaging, there were multiple nodules ranging in size up to 5cm in the longest dimension, with regularly shaped clear margins, in both lungs. We considered lung metastases of a malignant neoplasm as the most likely diagnosis and performed a systemic workup but failed to make a clinical diagnosis. We therefore performed an open lung biopsy on November 8. Microscopically, the tumors consisted of a mixture of areas with a papillary pattern, a solid pattern and a sclerosing pattern. Component tumor cells were of two types: epithelial-like cells that covered the surface of the papillary structures and round or polygonal cells that showed a solid pattern of growth underneath. Immunohistochemical examinations revealed that these tumor cells were positive for an alveolar epithelium marker. From these results, we made a diagnosis of sclerosing hemangioma. Here we report a rare case of multiple sclerosing hemangiomas together with a review of the literature.
authors.affiliation: Division of Respiratory Disease, Niigata City General Hospital.
authors.forename: Kazuhisa
authors.initials: K
authors.lastname: Ito
authors.forename: Takuro
authors.initials: T
authors.lastname: Sakagami
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Abe
authors.forename: Nanako
authors.initials: N
authors.lastname: Tsutsui
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Nakajima
authors.forename: Michihiko
authors.initials: M
authors.lastname: Haraguchi
mesh_terms: D000293:Adolescent; D001706:Biopsy; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008168:Lung / Q000473:pathology*; D008175:Lung Neoplasms / Q000000981:diagnostic imaging*; D047868:Pulmonary Sclerosing Hemangioma / Q000473:pathology*; D013902:Radiography, Thoracic; D003074:Solitary Pulmonary Nodule / Q000000981:diagnostic imaging*