Amino disaccharides having an alpha-(1-->4) or a beta-(1-->4) linkage, their synthesis and evaluation as a potential inhibitor for HIV-1 TAR-Tat.
Amino disaccharides having an alpha-(1-->4) linkage or a beta-(1-->4) linkage have been prepared as the mimics of amino glycoside antibiotics and their inhibition for HIV-1 TAR-Tat were examined. The compound having alpha-(1-->4) linkage denotes better inhibition for TAR-Tat than that of the one having beta-(1-->4).
Iguchi
Takashi
T
Shibaura Institute of Technology, Department of Applied Chemistry.
Ishikawa
Hirohumi
H
Matumoto
Hiroharu
H
Mizuno
Mamoru
M
Goto
Kohtaro
K
Hamasaki
Keita
K
D019380:Anti-HIV Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D004187:Disaccharides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D015696:Gene Products, tat / Q000037:antagonists & inhibitors*; D016325:HIV Long Terminal Repeat / Q000187:drug effects; D015497:HIV-1 / Q000187:drug effects*; D054322:tat Gene Products, Human Immunodeficiency Virus
C520203:2-aminoethyl 6-amino-6-deoxyglucosaminyl-1-4-2,6-diamino-2,6-dideoxyglucopyranoside; D019380:Anti-HIV Agents; D004187:Disaccharides; D015696:Gene Products, tat; D054322:tat Gene Products, Human Immunodeficiency Virus