title: Increasing prevalence of Salmonella enterica serotype Paratyphi-A in patients with enteric fever in a periurban slum setting of Kolkata, India.
abstract: A sudden rise in the occurrence of Salmonella enterica serotype Paratyphi-A (SPTA) was noted in a longitudinal community-based study in Kolkata, India, during 2004 - 2005. We compared the incidence rate of Salmonella enterica serotype Typhi (ST) and SPTA and their antimicrobial susceptibility pattern. Rate of isolation of SPTA was 1.5 times higher than that of ST, a trend detected for the first time in that particular focus. Almost all the isolates were sensitive to Gentamycin and Norfloxacin. Most of the strains (90%) were sensitive to Ciprofloxacin. Two thirds of the strains were also sensitive to Chloramphenicol. The high occurrence of SPTA in the present study could be the signal of the emergence of SPTA as a pathogen in India. Quinolone derivatives (namely, Ciprofloxacin, Norfloxacin and Chloramphenicol) can be suggested as drugs of choice for treatment of enteric fever caused by SPTA. Future vaccination strategies should include bivalent vaccines with protection capacities against both ST as well as SPTA.
authors.affiliation: Division of Microbiology, National Institute of Cholera & Enteric Diseases (ICMR), Kolkata, India. anup_palit@rediffmail.com
authors.forename: Anup
authors.initials: A
authors.lastname: Palit
authors.forename: Subrata
authors.initials: S
authors.lastname: Ghosh
authors.forename: Sanjucta
authors.initials: S
authors.lastname: Dutta
authors.forename: Dipika
authors.initials: D
authors.lastname: Sur
authors.forename: Mihir Kumar
authors.initials: MK
authors.lastname: Bhattacharya
authors.forename: Sujit Kumar
authors.initials: SK
authors.lastname: Bhattacharya
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology; D006801:Humans; D007194:India / Q000453:epidemiology; D008137:Longitudinal Studies; D008826:Microbial Sensitivity Tests; D010284:Paratyphoid Fever / Q000188:drug therapy / Q000453:epidemiology*; D011204:Poverty Areas; D015995:Prevalence; D012482:Salmonella paratyphi A / Q000187:drug effects / Q000302:isolation & purification*; D014435:Typhoid Fever / Q000188:drug therapy / Q000453:epidemiology*; D014505:Urban Population
chemical_list: D000890:Anti-Infective Agents