[Experimental model to induce obesity in rats].
The etiology of obesity is multifactorial and is becoming a problem of public health, due to its increased prevalence and the consequent repercussion of its comorbidities on the health of the population. The great similarity and homology between the genomes of rodents and humans make these animal models a major tool to study conditions affecting humans, which can be simulated in rats. Obesity can be induced in animals by neuroendocrine, dietary or genetic changes. The most widely used models to induce obesity in rats are a lesion of the ventromedial hypothalamic nucleus (VMH) by administering monosodium glutamate or a direct electrical lesion, ovariectomy, feeding on hypercaloric diets and genetic manipulation for obesity.
Von Diemen
Vinicius
V
Post-Graduate Program in Surgery, UFRGS, Brazil.
Trindade
Eduardo Neubarth
EN
Trindade
Manoel Roberto Maciel
MR
D000818:Animals; D004041:Dietary Fats / Q000008:administration & dosage; D004195:Disease Models, Animal; D005503:Food Additives; D006801:Humans; D008957:Models, Genetic; D009765:Obesity / Q000209:etiology* / Q000235:genetics; D010052:Ovariectomy; D051381:Rats; D012970:Sodium Glutamate; D014697:Ventromedial Hypothalamic Nucleus / Q000187:drug effects / Q000293:injuries; D015430:Weight Gain
D004041:Dietary Fats; D005503:Food Additives; D012970:Sodium Glutamate