Anti-influenza virus agents: synthesis and mode of action.
Annual epidemics of influenza virus infection are responsible for considerable morbidity and mortality, and pandemics are much more devastating. Considerable knowledge of viral infectivity and replication has been acquired, but many details still have to be elucidated and the virus remains a challenging target for drug design and development. This review provides an overview of the antiviral drugs targeting the influenza viral replicative cycle. Included are a brief description of their chemical syntheses and biological activities. For other reviews, see References1-9.
Lagoja
Irene M
IM
Laboratory of Medicinal Chemistry, Faculty of Pharmaceutical Sciences, Rega Institute for Medical Research, Minderbroedersstraat 10, B-3000 Leuven, Belgium.
De Clercq
Erik
E
D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002460:Cell Line; D006801:Humans; D009975:Orthomyxoviridae / Q000187:drug effects* / Q000502:physiology; D014779:Virus Replication / Q000187:drug effects / Q000502:physiology
D000998:Antiviral Agents