Effect of radioprotector indralin on carboplatinum hemotoxicity.
A decrease in carboplatinum hemotoxicity was detected in experiments on C57B1 mice treated with the drug in combination with indralin (urgent radioprotector). Carboplatinum in a dose of 125 mg/kg, injected intraperitoneally, caused 80-100% death; the median term of death was 6 days (3-17). Single oral dose of indralin (100 mg/kg) during the 1st min or 15 min after carboplatinum injection (125 mg/kg) increased animal survival by 40.0-46.7% by day 20 of the experiment primarily during the period of manifest hemotoxicity (days 7-17), indralin injected 1, 2, or 4 h after carboplatinum exhibited no chemoprotective effect.
Vasin
M V
MV
State Research and Experimental Institute of Military Medicine, Ministry of Defense of the Russian Federation, Moscow.
Ushakov
I B
IB
Kovtun
V Yu
VY
Komarova
S N
SN
Semenova
L A
LA
D000818:Animals; D000970:Antineoplastic Agents / Q000633:toxicity*; D001769:Blood / Q000187:drug effects* / Q000528:radiation effects*; D016190:Carboplatin / Q000633:toxicity*; D051379:Mice; D008810:Mice, Inbred C57BL; D010636:Phenols / Q000008:administration & dosage* / Q000494:pharmacology*; D011833:Radiation Injuries, Experimental / Q000517:prevention & control; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D013997:Time Factors
D000970:Antineoplastic Agents; D010636:Phenols; D011837:Radiation-Protective Agents; C086896:indralin; D016190:Carboplatin