title: Zinc transporter 7 is located in the cis-Golgi apparatus of mouse choroid epithelial cells.
abstract: The cellular localization of zinc transporter 7 protein in the mouse choroid plexus was examined in this study. Zinc transporter 7 immunoreactive cells were detected in the third, lateral, and fourth ventricles of CD-1 mouse brain. Distinct zinc transporter 7 immunoreactivity was concentrated in the perinuclear regions of the positive cells. The results from zinc autometallography showed that zinc-positive grains were also predominantly located in the perinuclear areas. Ultrastructural localization showed that zinc transporter 7 immunostaining was predominantly present in the membrane and cisternae of the cis-Golgi networks and some vesicle compartments. The results support the notion that zinc transporter 7 may participate in the transport of the cytoplasmic zinc into the Golgi apparatus, and may be involved in local packaging of zinc-binding proteins in the mouse choroid plexus.
authors.affiliation: Department of Histology and Embryology, China Medical University, Shenyang, Liaoning, PR China.
authors.forename: Zhi-Hong
authors.initials: ZH
authors.lastname: Chi
authors.forename: Xin
authors.initials: X
authors.lastname: Wang
authors.forename: Zhan-You
authors.initials: ZY
authors.lastname: Wang
authors.forename: Hui-Ling
authors.initials: HL
authors.lastname: Gao
authors.forename: Annica
authors.initials: A
authors.lastname: Dahlstrom
authors.forename: Liping
authors.initials: L
authors.lastname: Huang
mesh_terms: D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism*; D002831:Choroid Plexus / Q000166:cytology*; D004847:Epithelial Cells / Q000648:ultrastructure*; D006056:Golgi Apparatus / Q000378:metabolism*; D007150:Immunohistochemistry / Q000379:methods; D008297:Male; D051379:Mice; D046529:Microscopy, Electron, Transmission / Q000379:methods
chemical_list: D002352:Carrier Proteins; C017800:zinc-binding protein