Ultraviolet light and cutaneous lupus.
Exposure to ultraviolet (UV) light is one of the major factors known to trigger cutaneous disease activity in (systemic) lupus erythematosus patients. UV light, UVB in particular, is a potent inducer of apoptosis. Currently, disturbed clearance of apoptotic cells is one of the concepts explaining the development of inflammation in lupus patients. We review the role of apoptotic cells and autoantibodies in the pathogenesis of UVB induced skin lesions.
Bijl
Marc
M
Department of Internal Medicine, Division of Clinical Immunology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. m.bijl@int.umcg.nl
Kallenberg
Cees G M
CG
D017209:Apoptosis / Q000528:radiation effects; D001323:Autoantibodies / Q000528:radiation effects; D006801:Humans; D015603:Keratinocytes / Q000528:radiation effects; D008178:Lupus Erythematosus, Cutaneous / Q000209:etiology* / Q000276:immunology / Q000473:pathology / Q000503:physiopathology; D008180:Lupus Erythematosus, Systemic / Q000150:complications; D011832:Radiation Injuries / Q000209:etiology* / Q000276:immunology / Q000473:pathology / Q000503:physiopathology; D012867:Skin / Q000473:pathology / Q000528:radiation effects*; D014466:Ultraviolet Rays / Q000009:adverse effects*
D001323:Autoantibodies