Oral ciprofloxacin affects the pharmacokinetics of paracetamol in saliva.
BACKGROUND
To determine whether concomitant administration of ciprofloxacin has any effect on the release and absorption of paracetamol.


METHODS
Ten healthy female volunteers received a single oral dose of paracetamol 1g or paracetamol 1g plus ciprofloxacin 500mg in a double-blind, crossover study. Pharmacokinetic parameters were measured in salivary samples using a colorimetric method.


RESULTS
Maximum paracetamol concentration (C(max)) in saliva was significantly decreased when co-administered with ciprofloxacin (19.50 vs 13.70 microg/mL, p < 0.05). Time to paracetamol C(max) was significantly increased (1.43h vs 0.77h; p < 0.05) and paracetamol half-life was prolonged (1.19 to 1.53h, p = 0.05) in the presence of ciprofloxacin, whereas the area under the concentration-time curve was not affected.


CONCLUSIONS
Concomitant administration of ciprofloxacin with paracetamol may result in a delayed onset of action of paracetamol.
Issa
Mahmoud Mohamed
MM
Department of Chemistry, Pharmaceutical Analytical Chemistry, Alaqsa University, Gaza, Palestine, Palestine.
Nejem
R'afat Mahmoud
RM
El-Abadla
Naser Said
NS
D000082:Acetaminophen / Q000008:administration & dosage / Q000493:pharmacokinetics*; D000284:Administration, Oral; D000328:Adult; D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage / Q000493:pharmacokinetics; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000493:pharmacokinetics; D019540:Area Under Curve; D002939:Ciprofloxacin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D018592:Cross-Over Studies; D004311:Double-Blind Method; D004347:Drug Interactions; D005260:Female; D006207:Half-Life; D006801:Humans; D008657:Metabolic Clearance Rate; D012463:Saliva / Q000378:metabolism*
D018712:Analgesics, Non-Narcotic; D000890:Anti-Infective Agents; D000082:Acetaminophen; D002939:Ciprofloxacin