title: Surgical bypass versus endoscopic stenting for malignant gastroduodenal obstruction: a decision analysis.
abstract: The treatment options for palliating malignant gastroduodenal obstruction include open gastrojejunostomy (OGJ), laparoscopic gastrojejunostomy (LGJ), and endoscopic stenting (ES). The aim of this study was to compare the clinical outcomes and costs among ES, OGJ, and LGJ in patients who present with gastroduodenal obstruction from advanced upper gastrointestinal tract cancer. We designed a model for patients with malignant gastroduodenal obstruction. We analyzed success rates, complication rates and costs of the three treatment modalities: ES, OGJ, and LGJ. Baseline outcomes and costs were based on published reports. Success was defined as no major procedure-related and long-term complications over a 1-month period. Failure of therapy was defined as recurrent symptoms or death due to a procedural complication. Sensitivity analyses and cost-effectiveness analyses for the various strategies were performed. ES resulted in the lowest mortality rate and the lowest cost of the three treatment options analyzed. Mortality in the OGJ group was 2.1 times that in the ES cohort and 1.8 times that in the LGJ cohort. Sensitivity analyses confirmed ES as the dominant strategy. In conclusion, ES is the preferred treatment for palliation of duodenal obstruction due to advanced upper gastrointestinal tract cancer.
authors.affiliation: Division of Gastroenterology, VA North Texas Health Care System and University of Texas Southwestern Medical School, Dallas, Texas 75216, USA. Ali.siddiqui@utsouthwestern.edu
authors.forename: Ali
authors.initials: A
authors.lastname: Siddiqui
authors.forename: Stuart J
authors.initials: SJ
authors.lastname: Spechler
authors.forename: Sergio
authors.initials: S
authors.lastname: Huerta
mesh_terms: D003661:Decision Support Techniques; D003663:Decision Trees; D004379:Duodenal Neoplasms / Q000150:complications; D016099:Endoscopy, Gastrointestinal; D015390:Gastric Bypass; D005770:Gastrointestinal Neoplasms / Q000150:complications*; D006801:Humans; D007415:Intestinal Obstruction / Q000601:surgery / Q000628:therapy*; D010166:Palliative Care; D010190:Pancreatic Neoplasms / Q000150:complications; D015607:Stents; D013274:Stomach Neoplasms / Q000150:complications