title: The macrocyclic effect and vasodilation response based on the photoinduced nitric oxide release from trans-[RuCl(tetraazamacrocycle)NO](2+).
abstract: Irradiation of trans-[RuCl(cyclam)(NO)](2+), cyclam is 1,4,8,11-tetraazacyclotetradecane, at pHs 1-7.4, with near UV light results in the release of NO and formation of trans-[Ru(III)Cl(OH)(cyclam)](+) with pH dependent quantum yields (from approximately 0.01 to 0.16 mol Einstein(-1)) lower than that for trans-[RuCl([15]aneN(4))(NO)](2+), [15]aneN(4) is 1,4,8,12-tetaazacyclopentadecane, (0.61 mol Einstein(-1)). After irradiation with 355 nm light, the trans-[RuCl([15]aneN(4))(NO)](2+) induces relaxation of the aortic ring, whereas the trans-[RuCl(cyclam)(NO)](2+) complex does not. The relaxation observed with trans-[RuCl([15]aneN(4))(NO)](2+) is consistent with a larger quantum yield of release of NO from this complex.
authors.affiliation: Faculdade de Ciências Farmacêuticas de Ribeirão Preto, USP, Av do Café s/n, Ribeirão Preto CEP 14040-903, SP, Brazil.
authors.forename: Fabiana de Souza
authors.initials: Fde S
authors.lastname: Oliveira
authors.forename: Kleber Queiroz
authors.initials: KQ
authors.lastname: Ferreira
authors.forename: Daniella
authors.initials: D
authors.lastname: Bonaventura
authors.forename: Luziane M
authors.initials: LM
authors.lastname: Bendhack
authors.forename: Antonio Claudio
authors.initials: AC
authors.lastname: Tedesco
authors.forename: Sergio de P
authors.initials: Sde P
authors.lastname: Machado
authors.forename: Elia
authors.initials: E
authors.lastname: Tfouni
authors.forename: Roberto Santana
authors.initials: RS
authors.lastname: da Silva
mesh_terms: D000818:Animals; D006571:Heterocyclic Compounds / Q000737:chemistry / Q000494:pharmacology / Q000528:radiation effects; D066298:In Vitro Techniques; D008297:Male; D008958:Models, Molecular; D015394:Molecular Structure; D020030:Nitric Oxide Donors / Q000737:chemistry* / Q000494:pharmacology* / Q000528:radiation effects; D010777:Photochemistry; D051381:Rats; D017208:Rats, Wistar; D017975:Ruthenium Compounds / Q000737:chemistry* / Q000494:pharmacology* / Q000528:radiation effects; D014466:Ultraviolet Rays; D014665:Vasodilator Agents / Q000737:chemistry* / Q000494:pharmacology* / Q000528:radiation effects
chemical_list: D006571:Heterocyclic Compounds; D020030:Nitric Oxide Donors; D017975:Ruthenium Compounds; D014665:Vasodilator Agents; C024560:cyclam