Modern cell technologies in the treatment of patients with tympanic membrane injury inflicted by mine explosion.
We evaluated the efficiency of transplantation of cultured human allofibroblasts onto tympanic membrane damaged by mine explosion in combination with Tampograss dressing (Paul Hartman). Transplantation of cultured human allofibroblasts was effective in 100% cases. Application of the film with fibroblasts onto perforation occupying from 1/4 to 1/2 of the tympanic membrane was more effective by 15% (by 59% in subtotal perforation) than tympanoplasty with amnion membrane. The mean duration of tympanic membrane restoration after spontaneous healing and amnionoplasty is virtually the same, while transplantation of allofibroblasts accelerated the process in comparison with other groups in perforation of any size; in subtotal defect the duration of tympanic membrane restoration was shorter by 14 +/- 1 days.
Tumanov
V P
VP
Department of ENT Diseases, Therapeutic Faculty, Pediatric Faculty, Russian State Medical University, N. I. Pirogov Municipal Clinical Hospital No. 1, Moscow.
Pal'chun
V T
VT
Pomatilov
A A
AA
Polyakova
E V
EV
Zakharova
A V
AV
Yarygin
V N
VN
D000062:Accidents, Occupational; D000293:Adolescent; D000328:Adult; D017690:Cell Transplantation / Q000379:methods*; D005107:Explosions; D005260:Female; D005347:Fibroblasts / Q000166:cytology* / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D014432:Tympanic Membrane / Q000166:cytology* / Q000473:pathology; D018058:Tympanic Membrane Perforation / Q000473:pathology / Q000628:therapy*; D014945:Wound Healing