[Pathomechanisms in chronic obstructive pulmonary disease (COPD)].
Chronic obstructive pulmonary disease (COPD) is one of the most common chronic diseases worldwide, and its morbidity and mortality are still increasing. Thus, it is expected that, globally, COPD will be the third most common cause of death by 2020. Moreover, COPD leads to enormous health-economic costs (i. e., outpatient and inpatient treatment, inability to work). Nevertheless, the prevalence of COPD is underestimated also in Germany. This is partly because often, the disease is symptomatic only in its advanced stages and as a result it is not diagnosed until late. In addition, the therapeutic effects on the long-term course and the progression of the disease are limited. Therefore, a much deeper understanding of the manifold and complex pathomechanisms of this pathomorphologically varied disease is needed before new therapeutic strategies can be developed. The aim of this review is to discuss current concepts of the pathophysiology of COPD and their scientific bases. The authors will concentrate mainly on a differentiated description of the pathomechanisms which cause chronic obstructive bronchiolitis and obstructive pulmonary emphysema.
Glaab
Thomas
T
Abteilung Pneumologie, Medizinische Hochschule Hannover, Hannover, Deutschland.
Hohlfeld
Jens M
JM
Jörres
Rudolf A
RA
Krug
Norbert
N
Welte
Tobias
T
D000975:Antioxidants / Q000502:physiology; D017209:Apoptosis / Q000502:physiology; D016084:Bronchoconstriction; D003937:Diagnosis, Differential; D018450:Disease Progression; D005541:Forced Expiratory Volume; D005858:Germany / Q000453:epidemiology; D006801:Humans; D016877:Oxidants / Q000502:physiology; D018384:Oxidative Stress; D015995:Prevalence; D011650:Pulmonary Alveoli / Q000503:physiopathology; D029424:Pulmonary Disease, Chronic Obstructive / Q000145:classification / Q000175:diagnosis / Q000191:economics / Q000453:epidemiology / Q000503:physiopathology*; D011656:Pulmonary Emphysema / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology / Q000503:physiopathology; D020545:Respiratory Mucosa / Q000503:physiopathology; D012307:Risk Factors; D013147:Spirometry; D013997:Time Factors; D014797:Vital Capacity
D000975:Antioxidants; D016877:Oxidants