title: Liposarcoma in adult limbs treated by limb-sparing surgery and adjuvant radiotherapy.
abstract: Between December 1995 and March 2003, 38 adult patients with intermediate or high-grade liposarcoma in a limb were treated by limb-sparing surgery and post-operative radiotherapy. The ten-year local recurrence-free survival was 83%, the ten-year metastasis-free survival 61%, the ten-year disease-free survival 51% and the ten-year overall survival 67%. Analysis of failure and success showed no association with the age of the patients, gender, the location of the primary tumour, the type of liposarcoma and the quality of resection. Our results indicate that liposarcoma may recur even ten years after the end of definitive therapy and may spread to unexpected sites as for soft-tissue sarcoma.
authors.affiliation: Department of Pathology, Tel-Aviv Sourasky Medical Centre, Tel-Aviv, Israel.
authors.forename: J
authors.initials: J
authors.lastname: Issakov
authors.forename: V
authors.initials: V
authors.lastname: Soyfer
authors.forename: Y
authors.initials: Y
authors.lastname: Kollender
authors.forename: J
authors.initials: J
authors.lastname: Bickels
authors.forename: I
authors.initials: I
authors.lastname: Meller
authors.forename: O
authors.initials: O
authors.lastname: Merimsky
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017024:Chemotherapy, Adjuvant; D010478:Chemotherapy, Cancer, Regional Perfusion; D005121:Extremities; D005260:Female; D006801:Humans; D023821:Limb Salvage / Q000379:methods*; D008080:Liposarcoma / Q000188:drug therapy / Q000532:radiotherapy / Q000556:secondary / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D018714:Radiotherapy, Adjuvant; D012983:Soft Tissue Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery*; D016896:Treatment Outcome