[A case of pulmonary Langerhans cell histiocytosis discovered by CT mass screening and followed by bronchoalveolar lavage].
A 42-year-old woman who had a cigarette index of 420 had many cavitary lesions predominantly in the upper areas of both lungs. The lesions were detected on a health examination using CT. Analysis with bronchofiberscopy showed increased CD1a positive cells in bronchoalveolar fluid (BALF). Histological examination by video-associated lung biopsy demonstrated that both S-100 and vimentin-positive cells were present in the peribronchial fibrotic lesions. From these data, this disease was diagnosed as pulmonary Langerhans cell histiocytosis (PLCH). Three months after the cessation of smoking, the cavity lesions disappeared. As the image findings improved, CD1a positive cells in BALF decreased (4.9% --> 1.8%) and the CD4/CD8 ratio in BALF increased (1.66 --> 6.16). So far, there is no report describing the time course of both CD1a positive cells and CD4/CD8 ratio in BALF after cessation of smoking in PLCH. These findings attract our interest on the PLCH.
Watanabe
Hiroshi
H
Department of Respiratory Oncology and Molecular Medicine, Insititute of Development, Aging and Cancer, Tohoku University.
Maemondo
Makoto
M
Okouchi
Shinya
S
Suzuki
Takuji
T
Kikuchi
Toshiaki
T
Tazawa
Ryushi
R
Ebina
Masahito
M
Saijo
Yasuo
Y
Hoshikawa
Yasushi
Y
Nukiwa
Toshihiro
T
D000328:Adult; D018949:Antigens, CD1 / Q000032:analysis; D001992:Bronchoalveolar Lavage Fluid / Q000276:immunology*; D016516:CD4-CD8 Ratio; D005260:Female; D006646:Histiocytosis, Langerhans-Cell / Q000175:diagnosis*; D006801:Humans; D008400:Mass Chest X-Ray; D012907:Smoking / Q000009:adverse effects*; D016540:Smoking Cessation; D014057:Tomography, X-Ray Computed
D018949:Antigens, CD1; C419393:CD1a antigen