[Study on the relationship between endocrine hormone and prognosis in critically ill patients].
OBJECTIVE
To investigate the profile and significance of changes in thyroid function and cortisol in critically ill patients.


METHODS
Chemiluminescent microparticle immunoassay (CMIA) was used to measure the serum thyroid hormone, thyroid stimulating hormone and cortisol levels in 51 patients at the first day and in the 45 patients still alive at the third day after hospitalized in ICU. In the 45 patients, 17 cases were complicated with multiple organ dysfunction syndrome (MODS) and 28 cases were not. The age, blood glucose levels and APACHE II scores were also recorded at the first day.


RESULTS
In the 45 patients, serum FT(3) decreased in 41 patients (91%), cortisol increased in 33 patients (73%), especially in the first 24 hours. Compared with non-MODS group, serum FT(3), FT(4) and cortisol levels changed significantly in MODS group. Serum FT(4) reduced apparently in 6 dead patients. Serum FT(3) level was negatively correlated with APACHE II, and cortisol level was positively correlated with APACHE II.


CONCLUSIONS
Thyroid hormone and cortisol were apparently abnormal and correlated with APACHE II score, especially in patients with MODS. Serum FT(4) might serve as an index to judge the prognosis of the patients.
Li
Xu
X
Department of Intensive Care Unit, The First Affiliated Hospital of China Medical University, Shenyang 110001, China. xania_02_02@yahoo.com.cn
Zhang
Zhi-dan
ZD
Zhu
Ran
R
Ma
Xiao-chun
XC
D018806:APACHE; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016638:Critical Illness; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D013963:Thyroid Hormones / Q000097:blood*; D013997:Time Factors
D013963:Thyroid Hormones; D006854:Hydrocortisone