Identification of a Moraxella catarrhalis gene that confers adherence to various human epithelial cell lines in vitro.
Moraxella catarrhalis is a pathogen of the human airways. We found that expression of the M. catarrhalis gene mcmA by Escherichia coli increases adherence to epithelial cells 100-fold. Furthermore, we discovered that disrupting mcmA decreases M. catarrhalis adherence to laryngeal and lung cells, which are relevant to pathogenesis by the bacterium.
Lipski
Serena L
SL
Department of Medical Microbiology and Immunology, Medical University of Ohio, Toledo, OH 43614, USA.
Holm
Melissa M
MM
Lafontaine
Eric R
ER
D001422:Bacterial Adhesion / Q000235:genetics*; D018441:Biofilms; D002460:Cell Line; D004847:Epithelial Cells / Q000382:microbiology*; D004926:Escherichia coli / Q000235:genetics / Q000502:physiology; D005840:Gentian Violet / Q000032:analysis; D006801:Humans; D001936:Moraxella catarrhalis / Q000235:genetics* / Q000472:pathogenicity*; D016254:Mutagenesis, Insertional
D005840:Gentian Violet