Psychotropic effects of antiepileptic drugs.
BACKGROUND
Mood disorder symptoms are common in patients with epilepsy. Since antiepileptic drugs (AEDs) can affect these symptoms, knowledge of the psychotropic properties of AEDs is crucial. We review most studies of the psychotropic effects of AEDs that have involved potential psychiatric applications and have been reported in the psychiatric literature.


METHODS
We conducted a comprehensive literature search to identify relevant clinical trial reports on the efficacy of AEDs for mood disorders.


RESULTS
There have been few randomized controlled trials studying AED psychotropic properties in patients with epilepsy, but some randomized controlled trials of potential psychiatric indications for AEDs have been published. Data from these studies suggest that specific AEDs have mood stabilizing, anxiolytic, and antidepressant properties, while others may elicit depression, agitation, or psychosis.


CONCLUSIONS
Antiepileptic drug selection should consider potential effects on mood and behavior.
Ettinger
Alan B
AB
EEG Lab, North Shore-LIJ, Comprehensive Epilepsy Centers, 270-05 76th Ave., New Hyde Park, NY 11040, USA. aettinge@lij.edu
D000927:Anticonvulsants / Q000009:adverse effects / Q000627:therapeutic use*; D004827:Epilepsy / Q000188:drug therapy / Q000523:psychology; D006801:Humans; D019964:Mood Disorders / Q000139:chemically induced / Q000188:drug therapy* / Q000523:psychology*; D011619:Psychotropic Drugs / Q000009:adverse effects / Q000627:therapeutic use*
D000927:Anticonvulsants; D011619:Psychotropic Drugs