title: Exercise capacity is a predictor of cardiovascular events in patients with type 2 diabetes mellitus.
abstract: Peak exercise oxygen consumption (peak VO2), as measured by expired gas analysis, is an accurate, reproducible and reliable method for determining exercise capacity. In this study, a cohort of 468 patients with type 2 diabetes underwent graded exercise testing to measure peak VO2 at baseline; the cohort was followed for five years for the occurrence of cardiovascular disease (CVD) events. Patients who developed CVD events during the five-year follow-up period were found to have significantly lower baseline peak VO2, as compared to those who did not (p = 0.02). Analysis by gender showed that the mean peak VO2 in male patients who developed CVD events was significantly lower than the peak VO2 in those who did not (p < 0.03). Multiple Cox regression analysis also showed low peak VO2 to be an independent factor. In conclusion, patients with type 2 diabetes mellitus with reduced peak VO2 during exercise have a greater tendency to develop future CVD events.
authors.affiliation: Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado, USA. bseyoum@med.wayne.edu
authors.forename: Berhane
authors.initials: B
authors.lastname: Seyoum
authors.forename: Raymond O
authors.initials: RO
authors.lastname: Estacio
authors.forename: Paulos
authors.initials: P
authors.lastname: Berhanu
authors.forename: Robert W
authors.initials: RW
authors.lastname: Schrier
mesh_terms: D000328:Adult; D000368:Aged; D002318:Cardiovascular Diseases / Q000209:etiology*; D015331:Cohort Studies; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000503:physiopathology*; D005080:Exercise Test; D017079:Exercise Tolerance; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010101:Oxygen Consumption; D011237:Predictive Value of Tests; D016016:Proportional Hazards Models; D016032:Randomized Controlled Trials as Topic; D012307:Risk Factors; D013997:Time Factors