[Proteomics of breast cancer: From differential to functional analysis].
From differential analysis to identify biomarkers, to functional analysis for finding new therapeutic targets, proteomics bring new comprehensive information for a better understanding of the molecular basis of oncology and new perspectives for the clinic. However the major limitation of proteomic investigations, more generally of post-genomic approaches, remains the molecular and cellular complexity of the mammary gland that is still a major challenge.
Hondermarck
Hubert
H
JE 2488 ERI-8 INSERM Signalisation des facteurs de croissance dans le cancer du sein, IFR-118, Université des Sciences et Technologies de Lille, 59650 Villeneuve d'Ascq. hubert.hondermarck@univ-lille1.fr
D014408:Biomarkers, Tumor; D001943:Breast Neoplasms / Q000235:genetics / Q000378:metabolism*; D005260:Female; D020869:Gene Expression Profiling; D036281:Genetic Research; D006801:Humans; D007391:International Cooperation; D047908:Intracellular Signaling Peptides and Proteins / Q000502:physiology; D009363:Neoplasm Proteins / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology*; D040901:Proteomics / Q000458:organization & administration; D015398:Signal Transduction
D014408:Biomarkers, Tumor; D047908:Intracellular Signaling Peptides and Proteins; D009363:Neoplasm Proteins