Toll-like receptor-2-mediated C-C chemokine receptor 3 and eotaxin-driven eosinophil influx induced by Mycobacterium bovis BCG pleurisy.
An acute and persistent eosinophil infiltration is observed during Mycobacterium bovis BCG pleural infection in mice. Eosinophil accumulation, lipid body formation, and eotaxin production were significantly reduced in BCG-infected Toll-like receptor-2 (TLR2)-deficient mice compared to wild-type mice. Neutralization of eotaxin or CCR3 drastically inhibited BCG-induced eosinophil accumulation and lipid body formation, indicating that BCG-induced eosinophil recruitment and activation is largely dependent of TLR2-mediated eotaxin generation.
D'Avila
Heloisa
H
Laboratório de Imunofarmacologia, Departamento de Fisiologia e Farmacodinâmica, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Av. Brasil 4365, Manguinhos, Rio de Janeiro 21045-900, Brazil.
Almeida
Patrícia E
PE
Roque
Natália R
NR
Castro-Faria-Neto
Hugo C
HC
Bozza
Patrícia T
PT
D000818:Animals; D054413:Chemokine CCL11; D019742:Chemokines, CC / Q000502:physiology*; D002631:Chemotactic Factors, Eosinophil / Q000502:physiology*; D002634:Chemotaxis, Leukocyte / Q000276:immunology*; D004804:Eosinophils / Q000166:cytology / Q000276:immunology* / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D009163:Mycobacterium bovis / Q000276:immunology*; D054397:Receptors, CCR3; D019707:Receptors, Chemokine / Q000502:physiology*; D051195:Toll-Like Receptor 2 / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D014396:Tuberculosis, Pleural / Q000276:immunology* / Q000378:metabolism / Q000662:veterinary
C515457:Ccl11 protein, mouse; C515351:Ccr3 protein, mouse; D054413:Chemokine CCL11; D019742:Chemokines, CC; D002631:Chemotactic Factors, Eosinophil; D054397:Receptors, CCR3; D019707:Receptors, Chemokine; C493486:Tlr2 protein, mouse; D051195:Toll-Like Receptor 2