title: PU.1 and Junb: suppressing the formation of acute myeloid leukemia stem cells.
abstract: Improved understanding of the molecular pathways that suppress the genesis and maintenance of cancer stem cells will facilitate development of rationally targeted therapies. PU.1 is a transcription factor that is required for normal myelomonocytic differentiation in hematopoiesis, and reduced PU.1 activity has been associated with myeloid leukemogenesis in man and in mouse models. A recent study by Steidl et al. demonstrates that Junb and Jun, two AP-1 transcription factors, are critical downstream effectors of the tumor suppressor activity of PU.1, and that reduced expression of Junb, in particular, may be a common feature of acute myeloid leukemogenesis.
authors.affiliation: Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA.
authors.forename: Tim C P
authors.initials: TC
authors.lastname: Somervaille
authors.forename: Michael L
authors.initials: ML
authors.lastname: Cleary
mesh_terms: D000818:Animals; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000517:prevention & control*; D051379:Mice; D014411:Neoplastic Stem Cells / Q000502:physiology*; D011518:Proto-Oncogene Proteins / Q000502:physiology*; D016755:Proto-Oncogene Proteins c-jun / Q000502:physiology*; D015534:Trans-Activators / Q000502:physiology*; D025521:Tumor Suppressor Proteins / Q000502:physiology*; D000099232:Proto-Oncogene Protein Spi-1
chemical_list: D011518:Proto-Oncogene Proteins; D016755:Proto-Oncogene Proteins c-jun; D015534:Trans-Activators; D025521:Tumor Suppressor Proteins; D000099232:Proto-Oncogene Protein Spi-1