title: Cytosine-gated hole creation and transfer in DNA in aqueous solution.
abstract: The selenite radical, SeO3-, has been found to selectively produce the cytosyl radical upon one-electron oxidation of duplex DNA. This is at first a surprising result as SeO3- can only oxidize guanine of the DNA bases, implying that the transiently formed guanyl radical cation must transpose into the neutral cytosyl radical with loss of a proton. Back oxidation to produce the neutral guanyl radical, in competition with another fixation reaction, is observed.
authors.affiliation: Department of Chemistry, The University of Auckland, Auckland 1, New Zealand. r.anderson@auckland.ac.nz
authors.forename: Robert F
authors.initials: RF
authors.lastname: Anderson
authors.forename: Sujata S
authors.initials: SS
authors.lastname: Shinde
authors.forename: Andrej
authors.initials: A
authors.lastname: Maroz
mesh_terms: D003596:Cytosine / Q000737:chemistry*; D004247:DNA / Q000737:chemistry*; D006147:Guanine / Q000737:chemistry; D006860:Hydrogen Bonding; D015394:Molecular Structure; D012996:Solutions; D013057:Spectrum Analysis
chemical_list: D012996:Solutions; D006147:Guanine; D003596:Cytosine; D004247:DNA