title: Flushing out of cerebrospinal fluid as a therapy for acute cerebellar dysfunction caused by high dose of cytosine arabinoside: a case report.
abstract: High dose of cytosine arabinoside is usually used in treatment of acute myelogenous leukemia. Here we report 1 case of a child who developed neurologic toxicity and rapidly improved after flushing out of cerebral spinal fluid, suggesting it could be treatment in the acute phase of toxicity. Efficacy of this treatment could be explained by reducing cytosine arabinoside metabolites in central nervous system.
authors.affiliation: Unité d'Hematologie-Immunologie-Oncologie Pédiatrique, CHU Angers, France. IsPellier@chu-angers.fr
authors.forename: Isabelle
authors.initials: I
authors.lastname: Pellier
authors.forename: Bertrand
authors.initials: B
authors.lastname: Leboucher
authors.forename: Petronela
authors.initials: P
authors.lastname: Rachieru
authors.forename: Norbert
authors.initials: N
authors.lastname: Ifrah
authors.forename: Xavier
authors.initials: X
authors.lastname: Rialland
mesh_terms: D000293:Adolescent; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage / Q000009:adverse effects*; D002526:Cerebellar Diseases / Q000139:chemically induced* / Q000628:therapy*; D002555:Cerebrospinal Fluid; D003561:Cytarabine / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000150:complications / Q000188:drug therapy*; D008297:Male
chemical_list: D000964:Antimetabolites, Antineoplastic; D003561:Cytarabine