title: Synthesis of N-substituted indole derivatives via PIFA-mediated intramolecular cyclization.
abstract: [Structure: see text] A variety of N-arylated and N-alkylated indole derivatives were synthesized by way of a phenyliodine bis(trifluoroacetate) (PIFA)-mediated intramolecular cyclization. This novel method allows for the construction of an indole skeleton by joining the N-atom on the side chain to the benzene ring at the last synthetic step. Other novel pyrrole-fused aromatic compounds can also be achieved by this method.
authors.affiliation: College of Pharmaceuticals and Biotechnology, Tianjin University, 300072, PRC.
authors.forename: Yunfei
authors.initials: Y
authors.lastname: Du
authors.forename: Renhe
authors.initials: R
authors.lastname: Liu
authors.forename: Gregory
authors.initials: G
authors.lastname: Linn
authors.forename: Kang
authors.initials: K
authors.lastname: Zhao
mesh_terms: D003500:Cyclization; D005463:Fluoroacetates; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D007462:Iodobenzenes; D014269:Trifluoroacetic Acid / Q000737:chemistry
chemical_list: D005463:Fluoroacetates; D007211:Indoles; D007462:Iodobenzenes; C517666:phenyliodine(III) bis(trifluoroacetate); D014269:Trifluoroacetic Acid