Morphological change of a liposome induced by an oligonucleotide tagged with lipophilic unit.
We synthesized a conjugate molecule which consisted of DNA, cholesterol, and poly(ethylene glycol) as a spacer. When DNA duplex containing this simple conjugate was added to a liposome solution, interestingly, a pearling transformation of the liposome was observed. Such a morphological change of the liposome is required in the study of synthesizing an artificial cellular life, because the cell division is one of the essential characteristic of the life system.
Shohda
Koh-ichiroh
K
Department of Basic Science, Graduate School of Arts and Sciences, The University of Tokyo, Komaba, Meguro-ku, Tokyo 153-8902, Japan.
Sugawara
Tadashi
T
D001483:Base Sequence; D002784:Cholesterol / Q000737:chemistry; D008081:Liposomes / Q000737:chemistry*; D008969:Molecular Sequence Data; D009692:Nucleic Acid Heteroduplexes / Q000737:chemistry; D009841:Oligonucleotides / Q000737:chemistry / Q000494:pharmacology*
D008081:Liposomes; D009692:Nucleic Acid Heteroduplexes; D009841:Oligonucleotides; D002784:Cholesterol