The role of host PrP in Transmissible Spongiform Encephalopathies.
PrP has a central role in the Transmissible Spongiform Encephalopathies (TSEs), and mutations and polymorphisms in host PrP can profoundly alter the host's susceptibility to a TSE agent. However, precisely how host PrP influences the outcome of disease has not been established. To investigate this we have produced by gene targeting a series of inbred lines of transgenic mice expressing different PrP genes. This allows us to study directly the influence of the host PrP gene in TSEs. We have examined the role of glycosylation, point mutations, polymorphisms and PrP from different species on host susceptibility and the disease process both within the murine species and across species barriers.
Cancellotti
Enrico
E
Institute for Animal Health, Neuropathogenesis Unit, Ogston Building, KB, West Mains Road, Edinburgh, UK.
Barron
Rona M
RM
Bishop
Matthew T
MT
Hart
Patricia
P
Wiseman
Frances
F
Manson
Jean C
JC
D000818:Animals; D020022:Genetic Predisposition to Disease; D006031:Glycosylation; D051379:Mice; D017354:Point Mutation; D011110:Polymorphism, Genetic; D017096:Prion Diseases / Q000235:genetics / Q000378:metabolism* / Q000503:physiopathology; D011328:Prions / Q000235:genetics / Q000378:metabolism* / Q000502:physiology
D011328:Prions