[Laboratory evolutive aspects of children under paracoccidioidomycosis treatment].
The study of 38 children with paracoccidioidomycosis, aged up to 14, treated for 24 to 30 months with either a sulfonamide derivative or ketoconazole either alone or, after the use of amphotericin B. Laboratory data at admission were analyzed and compared with those of sequential tests after up to 30 months follow-up. Anemia, eosinophilia, increased bilirubin and aminotransferases normalized, in most patients, after three months treatment and hypoalbuminemia normalized after six months, suggesting that these laboratory findings are useful for monitoring early therapeutic response. Peripheral leucocytes, erythrocyte sedimentation rate, IgG, and serological titers for Paracoccidioides brasiliensis were increased and frequently normalized after nine to 12 months of treatment. They may be useful for monitoring the entire treatment and emphasize the need for long term treatment of paracoccidioidomycosis in children.
Nogueira
Maria Gorete dos Santos
MG
Hospital das Clinicas, Faculdade de Medicina, Universidade Federal do Estado de Minas Gerais, Belo Horizonte, MG. dagor@uol.com.br
Andrade
Gláucia Manzan Queiroz
GM
Tonelli
Edward
E
Diniz
Susana Nogueira
SN
Goes
Alfredo Miranda
AM
Cisalpino
Patrícia Silva
PS
D000293:Adolescent; D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D002648:Child; D005500:Follow-Up Studies; D006801:Humans; D007654:Ketoconazole / Q000627:therapeutic use; D010229:Paracoccidioidomycosis / Q000097:blood* / Q000188:drug therapy*; D013449:Sulfonamides / Q000627:therapeutic use; D013997:Time Factors
D000935:Antifungal Agents; D013449:Sulfonamides; D000666:Amphotericin B; D007654:Ketoconazole