title: Use of acid suppressive medications after laparoscopic antireflux surgery: prevalence and clinical indications.
abstract: Laparoscopic antireflux surgery (LARS) provides effective control of gastroesophageal reflux (GER) in more than 90% of patients. Despite this high success rate, some patients continue to consume acid suppressive medications after surgical intervention. In this study we evaluate the prevalence, clinical indications, and cause of use of acid reducing drugs in patients after LARS. Consecutive patients undergoing LARS for GERD were surveyed 2-3 years after surgery regarding use of acid suppressive medications, surgical outcome, and GERD specific symptoms. During the study period, 119 patients underwent LARS at our center. Ninety-eight (82%) were available for interview. Two patients died of unrelated causes and two declined to be interviewed. The remaining 94 individuals are the subject of this report. Ninety-four percent were satisfied with the outcome of surgery. Despite this high satisfaction rate, 37 of 94 (39%) were on antireflux medication (ARM; 62% proton pump inhibitors, 22% H2-receptor antagonists, and 16% others), with 70% using continuous medication. Of these patients, 54% took ARM after surgery for GERD-related symptoms, 95% of these patients responded to medical therapy, and yet again, 85% remained satisfied with the surgical outcome. Forty-six percent of patients on ARM after surgery had no GERD symptoms and took ARM for nonappropriate indications such as bloating. Only 47% of these responded to ARM; 82% of this group was satisfied with the surgical outcome. In conclusion, the use of ARM after LARS is a common occurrence despite a high satisfaction rate with this operation. Nearly half of patients consuming ARS after LARS are taking these medications for symptoms not necessarily related to GER. These findings underscore the importance of patient education in the use of these agents.
authors.affiliation: Department of Surgery, Mayo Clinic Jacksonville, 4500 San Pablo Road, Jacksonville, Florida 32224, USA.
authors.forename: Hugo
authors.initials: H
authors.lastname: Bonatti
authors.forename: Tanja
authors.initials: T
authors.lastname: Bammer
authors.forename: Sami R
authors.initials: SR
authors.lastname: Achem
authors.forename: Frank
authors.initials: F
authors.lastname: Lukens
authors.forename: Kenneth R
authors.initials: KR
authors.lastname: DeVault
authors.forename: Alexander
authors.initials: A
authors.lastname: Klaus
authors.forename: Ronald A
authors.initials: RA
authors.lastname: Hinder
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004363:Drug Utilization; D005194:Family Practice / Q000706:statistics & numerical data; D005260:Female; D018662:Fundoplication; D005762:Gastroenterology / Q000706:statistics & numerical data; D005764:Gastroesophageal Reflux / Q000601:surgery*; D006635:Histamine H2 Antagonists / Q000627:therapeutic use*; D006801:Humans; D010535:Laparoscopy; D008297:Male; D008875:Middle Aged; D010353:Patient Education as Topic; D017060:Patient Satisfaction; D011184:Postoperative Period; D010818:Practice Patterns, Physicians'; D054328:Proton Pump Inhibitors; D012651:Self Medication / Q000706:statistics & numerical data; D016896:Treatment Outcome
chemical_list: D006635:Histamine H2 Antagonists; D054328:Proton Pump Inhibitors