Design, synthesis and evaluation of oligomer conjugated MGBpolyamide-nucleoside hybrid as a novel gene expression control compound.
DNA oligomers conjugated pyrrolepolyamide (minor groove binder)-deoxyguanosine hybrid were synthesized as novel gene expression control compounds. From T(m) values and CD spectral analysis, it was found that oligomers conjugated hybrid possess high recognition ability and very high binding ability for the DNA that includes pyrrolepolyamide match site.
Kawashima
Etsuko
E
School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.
Ohba
Yusuke
Y
Terui
Yusuke
Y
Kamaike
Kazuo
K
D002942:Circular Dichroism; D004247:DNA / Q000737:chemistry; D003849:Deoxyguanosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D005786:Gene Expression Regulation; D015316:Genetic Therapy; D020319:Oligodeoxyribonucleotides, Antisense / Q000737:chemistry*; D011758:Pyrroles / Q000138:chemical synthesis / Q000737:chemistry*; D013696:Temperature
C520215:2'-deoxy-N(2)-(3-(4-(4-(4-formamido-1-methylpyrrole-2-carboxamido)-1-methylpyrrole-2-carboxamido)-1-methylpyrrole-2-carboxamido)propyl)guanosine; D020319:Oligodeoxyribonucleotides, Antisense; D011758:Pyrroles; D004247:DNA; D003849:Deoxyguanosine