title: Zincergic innervation of the forebrain distinguishes epilepsy-prone from epilepsy-resistant rat strains.
abstract: Zinc is released from a subset of cerebral cortical neurons whereupon it exerts a powerful modulatory influence on excitatory and inhibitory neurotransmission. A number of studies have suggested that alterations in the regulation of zinc may contribute to the genesis of epilepsy. Here, we tested this hypothesis by examining the distribution of zinc-containing axon terminals in rats selectively bred for an innate susceptibility (FAST) or resistance (SLOW) to the development of kindling-induced seizures. Zinc was stained histochemically and levels of staining were quantitatively assessed. We found that the levels of synaptic zinc were significantly lower in the SLOW rats throughout the telencephalon. This relative reduction was most pronounced in limbic cortices where levels were less than 30% of FAST rats. These results suggest that innate differences in the homeostatic regulation of synaptic zinc, particularly in limbic cortices, may underlie differences in epileptogenicity.
authors.affiliation: Department of Psychology, University of Calgary, 2500 University Drive, Northwest, Calgary, Alberta, Canada T2N 1N4.
authors.forename: C
authors.initials: C
authors.lastname: Flynn
authors.forename: C E
authors.initials: CE
authors.lastname: Brown
authors.forename: S L
authors.initials: SL
authors.lastname: Galasso
authors.forename: D C
authors.initials: DC
authors.lastname: McIntyre
authors.forename: G Campbell
authors.initials: GC
authors.lastname: Teskey
authors.forename: R H
authors.initials: RH
authors.lastname: Dyck
mesh_terms: D000344:Afferent Pathways / Q000378:metabolism* / Q000503:physiopathology; D000818:Animals; D004195:Disease Models, Animal; D004827:Epilepsy / Q000235:genetics / Q000378:metabolism* / Q000503:physiopathology; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006651:Histocytochemistry; D007113:Immunity, Innate / Q000235:genetics*; D007696:Kindling, Neurologic / Q000235:genetics; D017729:Presynaptic Terminals / Q000378:metabolism; D016548:Prosencephalon / Q000033:anatomy & histology / Q000378:metabolism* / Q000503:physiopathology; D051381:Rats; D011922:Rats, Mutant Strains; D015032:Zinc / Q000378:metabolism*
chemical_list: D015032:Zinc