title: International Staging System required standardization of biochemical laboratory testing in multiple myeloma.
abstract: The standardization of biochemical measurement procedures in multiple myeloma is necessary for reliable prognostic stratification of patients in multicentric trials. The new prognostic index International Staging System for multiple myeloma uses only two laboratory markers, albumin and beta-2 microglobulin. Our study compared results of albumin, beta-2 microglobulin and monoclonal immunoglobulin measurements from six centers which provide treatment for multiple myeloma in the Czech Republic and attempted to standardize the analytic procedures. We have found that the measurement of albumin is well standardized and the results from all laboratories were comparable. The measurement of beta-2 microglobulin achieved comparability only after a partial unification of analytical methods. The determination of monoclonal immunoglobulin concentration provided comparable results for concentrations higher than 20 g/l with higher variability for lower values.
authors.affiliation: Institute of Clinical Biochemistry, Charles University Hospital, 500 05 Hradec Králové, Czech Republic. tichy@fnhk.cz
authors.forename: M
authors.initials: M
authors.lastname: Tichý
authors.forename: V
authors.initials: V
authors.lastname: Maisnar
authors.forename: V
authors.initials: V
authors.lastname: Palicka
authors.forename: B
authors.initials: B
authors.lastname: Friedecký
authors.forename: J
authors.initials: J
authors.lastname: Vávrová
authors.forename: H
authors.initials: H
authors.lastname: Novotná
authors.forename: Z
authors.initials: Z
authors.lastname: Cermáková
authors.forename: M
authors.initials: M
authors.lastname: Dastych
authors.forename: P
authors.initials: P
authors.lastname: Cechák
authors.forename: D
authors.initials: D
authors.lastname: Vogtová
authors.forename: E
authors.initials: E
authors.lastname: Jarolímková
authors.forename: H
authors.initials: H
authors.lastname: Benáková
authors.forename: L
authors.initials: L
authors.lastname: Hachová
authors.forename: D
authors.initials: D
authors.lastname: Bezdícková
authors.forename: F
authors.initials: F
authors.lastname: Kouril
authors.forename: E A
authors.initials: EA
authors.lastname: Zábranská
authors.forename: J
authors.initials: J
authors.lastname: Zenková
authors.forename: P
authors.initials: P
authors.lastname: Slabý
authors.forename: V
authors.initials: V
authors.lastname: Scudla
authors.forename: E
authors.initials: E
authors.lastname: Gregora
authors.forename: I
authors.initials: I
authors.lastname: Spicka
authors.forename: J
authors.initials: J
authors.lastname: Straub
authors.forename: M
authors.initials: M
authors.lastname: Schützova
authors.forename: R
authors.initials: R
authors.lastname: Hájek
mesh_terms: D000911:Antibodies, Monoclonal / Q000097:blood; D018153:Czech Republic; D003937:Diagnosis, Differential; D006801:Humans; D007075:Immunoglobulin M / Q000032:analysis; D007753:Laboratories / Q000592:standards*; D009101:Multiple Myeloma / Q000097:blood* / Q000145:classification / Q000473:pathology; D009367:Neoplasm Staging / Q000592:standards*; D011379:Prognosis; D012015:Reference Standards; D015203:Reproducibility of Results; D012709:Serum Albumin / Q000032:analysis*; D001613:beta 2-Microglobulin / Q000097:blood*
chemical_list: D000911:Antibodies, Monoclonal; D007075:Immunoglobulin M; D012709:Serum Albumin; D001613:beta 2-Microglobulin