title: Exploiting large scale computing to construct high resolution linkage disequilibrium maps of the human genome.
abstract: Linkage disequilibrium (LD) maps increase power and precision in association mapping, define optimal marker spacing and identify recombination hot-spots and regions influenced by natural selection. Phase II of HapMap provides approximately 2.8-fold more single nucleotide polymorphisms (SNPs) than phase I for constructing higher resolution maps. LDMAP-cluster, is a parallel program for rapid map construction in a Linux environment used here to construct genome-wide LD maps with >8.2 million SNPs from the phase II data.
  
  
  BACKGROUND
  The LD maps, LDMAP-cluster and documentation are available from: http://www.som.soton.ac.uk/research/geneticsdiv/epidemiology/LDMAP.
  
  
  BACKGROUND
  Supplementary data are available at Bioinformatics online.
authors.affiliation: Human Genetics Division, Duthie Building (Mailpoint 808), Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK.
authors.forename: Winston
authors.initials: W
authors.lastname: Lau
authors.forename: Tai-Yue
authors.initials: TY
authors.lastname: Kuo
authors.forename: William
authors.initials: W
authors.lastname: Tapper
authors.forename: Simon
authors.initials: S
authors.lastname: Cox
authors.forename: Andrew
authors.initials: A
authors.lastname: Collins
mesh_terms: D000465:Algorithms; D002874:Chromosome Mapping / Q000379:methods*; D016000:Cluster Analysis; D003205:Computing Methodologies; D005819:Genetic Markers / Q000235:genetics*; D005828:Genetics, Population; D015894:Genome, Human / Q000235:genetics*; D006801:Humans; D015810:Linkage Disequilibrium / Q000235:genetics*; D012680:Sensitivity and Specificity; D012984:Software
chemical_list: D005819:Genetic Markers