Aspirin antagonism in isoniazid treatment of tuberculosis in mice.
Salicylate has previously been shown to reduce the susceptibility of Mycobacterium tuberculosis to several drugs in vitro. In this study, aspirin, a salicylate anti-inflammatory, antagonized isoniazid treatment of murine pulmonary tuberculosis, whereas the nonsalicylate ibuprofen did not. These results may have implications on concurrent administration of anti-inflammatory and antituberculosis drugs.
Byrne
Sean T
ST
Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, 615 N. Wolfe Street, Baltimore, MD 21205, USA.
Denkin
Steven M
SM
Zhang
Ying
Y
D000818:Animals; D000995:Antitubercular Agents / Q000494:pharmacology*; D001241:Aspirin / Q000494:pharmacology*; D004336:Drug Antagonism; D004359:Drug Therapy, Combination; D007052:Ibuprofen / Q000494:pharmacology; D007538:Isoniazid / Q000494:pharmacology*; D051379:Mice; D008807:Mice, Inbred BALB C; D009169:Mycobacterium tuberculosis; D014376:Tuberculosis / Q000188:drug therapy*
D000995:Antitubercular Agents; D001241:Aspirin; D007538:Isoniazid; D007052:Ibuprofen