Synthesis of three natural diosgenyl glycosides.
Three well-known natural diosgenyl glycosides which have the same sugar chains but different sequence, ophipogonin C', polyphillin C and prosapogenin B, were synthesised by a facile approach. A method using the levulinyl group as a protecting group to selectively mask the C3-OH of diosgenyl 4,6-O-benzylidene-beta-D-glucopyranoside is described.
Hou
S-J
SJ
Key Laboratory of Bioactive Substance and Resources Utilisation of Chinese Herbal Medicine, Peking Union Medical College, Beijing, 100050, China.
Zou
C-C
CC
Zhou
L
L
Lei
P-S
PS
Yu
D-Q
DQ
D002855:Chromatography, Thin Layer; D004144:Diosgenin / Q000031:analogs & derivatives* / Q000138:chemical synthesis*; D006027:Glycosides / Q000138:chemical synthesis*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D015394:Molecular Structure
D006027:Glycosides; C517909:ophipogonin C'; C517908:polyphillin C; C517907:prosapogenin B; D004144:Diosgenin