title: Postevacuation hCG levels and risk of gestational trophoblastic neoplasia among women with partial molar pregnancies.
abstract: OBJECTIVE
  To develop human chorionic gonadotropin (hCG) criteria that determine a patient's risk of developing persistent gestational trophoblastic neoplasia (GTN) or achieving remission after partial mole evacuation.
  
  
  METHODS
  We used a database from the New England Trophoblastic Disease Center to analyze hCG levels from 284 women with partial molar pregnancies diagnosed between 1973 and 2003.
  
  
  RESULTS
  An hCG level >199 mIU/mL in the third through eighth week following molar evacuation was associated with at least a 35% risk of GTN.
  
  
  CONCLUSIONS
  Women with partial mole who have elevated hCG levels within the first few weeks after molar evacuation are at increased risk for developing GTN.
authors.affiliation: Donald P. Goldstein, M.D., Trophoblastic Tumor Registry, New England Trophoblastic Disease Center, USA.
authors.forename: Whitfield B
authors.initials: WB
authors.lastname: Growdon
authors.forename: Adam J
authors.initials: AJ
authors.lastname: Wolfberg
authors.forename: Colleen M
authors.initials: CM
authors.lastname: Feltmate
authors.forename: Donald P
authors.initials: DP
authors.lastname: Goldstein
authors.forename: David R
authors.initials: DR
authors.lastname: Genest
authors.forename: Manuel E
authors.initials: ME
authors.lastname: Chinchilla
authors.forename: Ross S
authors.initials: RS
authors.lastname: Berkowitz
authors.forename: Ellice S
authors.initials: ES
authors.lastname: Lieberman
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood*; D006063:Chorionic Gonadotropin / Q000097:blood*; D005260:Female; D031901:Gestational Trophoblastic Disease / Q000209:etiology*; D006801:Humans; D006828:Hydatidiform Mole / Q000097:blood / Q000150:complications*; D011247:Pregnancy; D012189:Retrospective Studies; D012306:Risk
chemical_list: D014408:Biomarkers, Tumor; D006063:Chorionic Gonadotropin