title: Therapeutic advances for glioblastoma multiforme: current status and future prospects.
abstract: Glioblastoma multiforme (GBM) is the most common central nervous system malignancy. It is rapidly progressive with rare opportunity for cure. After three decades of laboratory and clinical research, a newly evolved chemoradiotherapy approach using the alkylating agent temozolomide during and after radiotherapy has resulted in the first significant impact on this disease. Here we discuss the basis for this positive interaction as well as potential mechanisms of resistance to it. Additionally, in the context of current and planned research, we explore approaches to take advantage of this combination and the use of targeted therapies to exploit cell signaling alterations found in GBM. We anticipate that a multimodality approach directed at tumor-specific biology will result in more meaningful advancements in the treatment of this fatal disease.
authors.affiliation: University of Wisconsin Comprehensive Cancer Center, Madison, WI 53792, USA. hirobins@wisc.edu
authors.forename: H Ian
authors.initials: HI
authors.lastname: Robins
authors.forename: Susan
authors.initials: S
authors.lastname: Chang
authors.forename: Nicholas
authors.initials: N
authors.lastname: Butowski
authors.forename: Minesh
authors.initials: M
authors.lastname: Mehta
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001932:Brain Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D003131:Combined Modality Therapy; D005544:Forecasting; D005909:Glioblastoma / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D006801:Humans
chemical_list: D000970:Antineoplastic Agents