Attention and non-REM sleep in neuroleptic-naive persons with schizophrenia and control participants.
The relationship between sleep architecture and attentional performance was evaluated in neuroleptic-naive patients with schizophrenia and healthy controls. Participants were recorded in a sleep laboratory for two consecutive nights after which selective and sustained attention performance was tested. In both groups of participants, Spearman's rho statistics revealed a negative correlation between reaction time on the selective attention task and sleep spindle density. Only control participants showed a negative correlation between reaction time and duration of stage 2 sleep and a positive correlation between reaction time and duration of stage 1 ("light") sleep. Only persons with schizophrenia showed a negative correlation between reaction time and duration of stage 4 ("deep") sleep. In the sustained attention task, we found no correlation between reaction time and sleep for control participants while persons with schizophrenia showed a negative correlation between reaction time and duration of stage 4 sleep. It is proposed that EEG sleep spindle activity is associated with automatic attentional processing, while stage 2 sleep continuity in healthy individuals and percentage of stage 4 in patients with schizophrenia are associated with voluntary processes. These results support the existence of a relationship between non-rapid-eye-movement sleep and cognitive performance in healthy individuals as well as in persons with schizophrenia.
Forest
Geneviève
G
Centre de recherche Fernand-Seguin, Hôpital Louis-H. Lafontaine, 7331 Hochelaga, Montreal, Quebec, Canada H1N 3V2.
Poulin
Julie
J
Daoust
Anne-Marie
AM
Lussier
Isabelle
I
Stip
Emmanuel
E
Godbout
Roger
R
D000208:Acute Disease; D000328:Adult; D014150:Antipsychotic Agents; D001288:Attention / Q000502:physiology*; D001332:Automatism; D002680:Chin; D003072:Cognition Disorders / Q000175:diagnosis / Q000453:epidemiology; D004569:Electroencephalography; D004576:Electromyography; D004585:Electrooculography; D005133:Eye Movements / Q000502:physiology; D005260:Female; D006760:Hospitalization; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D011930:Reaction Time / Q000502:physiology; D012559:Schizophrenia / Q000453:epidemiology / Q000503:physiopathology* / Q000534:rehabilitation; D012720:Severity of Illness Index; D012894:Sleep Stages / Q000502:physiology*; D013997:Time Factors
D014150:Antipsychotic Agents