Stable hairpins having a loop consisting of 3'-deoxy-4'-C-(2-hydroxyethyl)thymidines.
A novel sugar-modified thymidine analogue, 3'-deoxy-4'-C-(2-hydroxyethyl)thymidine (X), was designed and synthesized to show that it can stabilize hairpin structures when it is present in the loop moiety, probably due to the flexibility of the one-carbon-elongated 4'-branched structure.
Shuto
Satoshi
S
Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.
Tamura
Yutaka
Y
Yamamoto
Yuji
Y
Kodama
Tetsuya
T
Hoshika
Shuichi
S
Ichikawa
Satoshi
S
Ueno
Yoshihito
Y
Ohtsuka
Eiko
E
Komatsu
Yasuo
Y
Matsuda
Akira
A
D002942:Circular Dichroism; D019295:Computational Biology; D004720:Endonucleases / Q000378:metabolism; D009690:Nucleic Acid Conformation; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis / Q000378:metabolism; D013816:Thermodynamics; D013936:Thymidine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry*; D044366:Transition Temperature
C521145:3'-deoxy-4'-C-(2-hydroxyethyl)thymidine; D009838:Oligodeoxyribonucleotides; D004720:Endonucleases; D013936:Thymidine