title: Vitamin A deficiency alters pulmonary parenchymal collagen and tissue mechanics.
abstract: The mechanical properties of the pulmonary parenchyma are strongly influenced by the collagen and elastic fibers that course through the alveolar interstitium and interconnect the bronchovascular bundles. Vitamin A deficiency (VAD) produces effacement and remodeling of the alveolar architecture, resulting in alternating areas of alveolar dilatation and collapse. To better understand the mechanical consequences and reversibility of this remodeling process, we have examined how the remodeling of collagen and elastic fibers correlates with the mechanical properties of the lung parenchyma in VAD rats. An oscillatory impulse was applied at different levels of stress on the fiber network and the tissue damping (G), elastance (H), hysteresivity (G/H, eta) were analyzed. At a supra-physiological functional residual capacity, the lung parenchyma of VAD rats exhibited a lower G and H than Vitamin A sufficient (VAS) rats, which was accompanied by a significant decrease in the quantity of parenchymal collagen and collagen fibers. Retinoic acid (RA) administration restored the parenchymal collagen and mechanical properties.
authors.affiliation: Department of Veterans Affairs Research Service, University of Iowa Carver College of Medicine, IA, USA. Stephen-mcgowan@uiowa.edu
authors.forename: S E
authors.initials: SE
authors.lastname: McGowan
authors.forename: A J
authors.initials: AJ
authors.lastname: Holmes
mesh_terms: D000399:Air Pressure; D000818:Animals; D003094:Collagen / Q000378:metabolism*; D004548:Elasticity; D004549:Elastin / Q000378:metabolism; D005260:Female; D008168:Lung / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology*; D008176:Lung Volume Measurements; D008855:Microscopy, Electron, Scanning; D009127:Muscle Rigidity / Q000503:physiopathology; D011175:Positive-Pressure Respiration; D011650:Pulmonary Alveoli / Q000502:physiology; D001261:Pulmonary Atelectasis / Q000503:physiopathology; D051381:Rats; D011917:Rats, Inbred Lew; D012121:Respiration, Artificial; D015656:Respiratory Mechanics / Q000502:physiology*; D035441:Thoracic Wall / Q000503:physiopathology; D014802:Vitamin A Deficiency / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology*
chemical_list: D003094:Collagen; D004549:Elastin