Signal transduction mechanisms in memory disorders.
This chapter explores some of the molecular events contributing to memory formation and how, when these events malfunction, disturbances in memory occur. After a brief discussion of signaling in the hippocampus, we will explore the topics of human mental retardation syndromes that involve disruption of these processes, including Angelman syndrome (AS), Neurofibromatosis 1 (NF1)-associated learning disorders, Coffin-Lowry syndrome (CLS), Rubinstein-Taybi syndrome (RTS), and Rett syndrome (RTT).
Shalin
Sara C
SC
Department of Neuroscience, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.
Egli
Regula
R
Birnbaum
Shari G
SG
Roth
Tania L
TL
Levenson
Johathan M
JM
Sweatt
J David
JD
D000818:Animals; D006624:Hippocampus / Q000503:physiopathology; D006801:Humans; D008607:Intellectual Disability / Q000503:physiopathology; D008569:Memory Disorders / Q000503:physiopathology*; D015398:Signal Transduction / Q000502:physiology*