Roles of nitric oxide synthase inhibitor on antinociceptive effects of mu-opioid agonist in mice.
In the present study, it was found that intraperitoneal (i.p.) pre-injection of N(G)-nitro-L-arginine methyl ester (L-NAME) significantly influenced the endomorphin-1 (EM-1) and endomorphin-2 (EM-2) induced antinociception. These effects could be inhibited or reversed by L-Arg or naloxone. Our results suggest that the modulatory effect of NO system on the mu-receptor evoked analgesia is different between the two mu receptor subtypes.
Chena
Li-Xiang
LX
Department of Bioengineering, Zhengzhou University, 100 Science Road, Zhengzhou, 450001, Peoples Republic of China.
Qia
Yuan-Ming
YM
Wangb
Rui
R
Duan
Xin
X
Gao
Yan-Feng
YF
Yang
Ding-Jian
DJ
D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D008297:Male; D051379:Mice; D019331:NG-Nitroarginine Methyl Ester / Q000494:pharmacology*; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors*; D009842:Oligopeptides / Q000494:pharmacology*; D010146:Pain / Q000188:drug therapy*; D017450:Receptors, Opioid, mu / Q000819:agonists*
D000700:Analgesics; D004791:Enzyme Inhibitors; D009842:Oligopeptides; D017450:Receptors, Opioid, mu; C105293:endomorphin 1; C105294:endomorphin 2; D019001:Nitric Oxide Synthase; D019331:NG-Nitroarginine Methyl Ester