title: Severe Japanese spotted fever successfully treated with fluoroquinolone.
abstract: A 77 years old woman who had a bite with eschar on her left arm, was admitted to emergency ward in our hospital, because of high fever, severe malaise, skin eruption, and consciousness disturbance beginning 5 days previously. She was diagnosed as Japanese spotted fever by seropositive of Rickettsia japonica (R. japonica) antibody, and successfully treated with fluoroquinolone, after minocycline hydrochloride had been proven ineffective. R. japonica-specific DNA was detected by PCR from the tick: Haemaphysalis hystricis larvae collected from a mountainous location in Fukuoka, Japan where the patient had been bitten.
authors.affiliation: Nagasaki University Graduate School of Biomedical Sciences, Department of Molecular Microbiology and Immunology, the Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan.
authors.forename: Masafumi
authors.initials: M
authors.lastname: Seki
authors.forename: Naruhiko
authors.initials: N
authors.lastname: Ikari
authors.forename: Seigo
authors.initials: S
authors.lastname: Yamamoto
authors.forename: Yuhki
authors.initials: Y
authors.lastname: Yamagata
authors.forename: Kosuke
authors.initials: K
authors.lastname: Kosai
authors.forename: Katsunori
authors.initials: K
authors.lastname: Yanagihara
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Kakugawa
authors.forename: Shintaro
authors.initials: S
authors.lastname: Kurihara
authors.forename: Koichi
authors.initials: K
authors.lastname: Izumikawa
authors.forename: Yoshitsugu
authors.initials: Y
authors.lastname: Miyazaki
authors.forename: Yasuhito
authors.initials: Y
authors.lastname: Higashiyama
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Hirakata
authors.forename: Takayoshi
authors.initials: T
authors.lastname: Tashiro
authors.forename: Shigeru
authors.initials: S
authors.lastname: Kohno
mesh_terms: D000368:Aged; D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D004269:DNA, Bacterial / Q000302:isolation & purification; D005260:Female; D024841:Fluoroquinolones / Q000627:therapeutic use*; D006801:Humans; D007564:Japan; D008911:Minocycline / Q000627:therapeutic use; D016133:Polymerase Chain Reaction; D019233:Retreatment; D012281:Rickettsia / Q000235:genetics; D012282:Rickettsia Infections / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology*; D012720:Severity of Illness Index; D013987:Ticks / Q000737:chemistry / Q000382:microbiology; D017211:Treatment Failure; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D004269:DNA, Bacterial; D024841:Fluoroquinolones; D008911:Minocycline