Loss of embryonic MET signaling alters profiles of hippocampal interneurons.
Hippocampal interneurons arise in the ventral forebrain and migrate dorsally in response to cues, including hepatocyte growth factor/scatter factor which signals via its receptor MET. Examination of the hippocampus in adult mice in which MET had been inactivated in the embryonic proliferative zones showed an increase in parvalbumin-expressing cells in the dentate gyrus, but a loss of these cells in the CA3 region. An overall loss of calretinin-expressing cells was seen throughout the hippocampus. A similar CA3 deficit of parvalbumin and calretinin cells was observed when MET was eliminated only in postmitotic cells. These data suggest that MET is required for the proper hippocampal development, and embryonic perturbations lead to long-term anatomical defects with possible learning and memory dysfunction.
Martins
Gabriela J
GJ
Program in Neuroscience, University of Maryland School of Medicine, Baltimore, MD 21201, USA. gmart001@umaryland.edu
Plachez
Céline
C
Powell
Elizabeth M
EM
D000818:Animals; D017209:Apoptosis / Q000235:genetics; D064032:Calbindin 2; D002135:Calcium-Binding Proteins / Q000378:metabolism*; D002452:Cell Count; D015536:Down-Regulation / Q000235:genetics; D018507:Gene Expression Regulation, Developmental / Q000235:genetics; D006624:Hippocampus / Q000002:abnormalities* / Q000166:cytology / Q000378:metabolism*; D007395:Interneurons / Q000166:cytology / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D009433:Neural Inhibition / Q000235:genetics; D009434:Neural Pathways / Q000002:abnormalities / Q000166:cytology / Q000378:metabolism; D010320:Parvalbumins / Q000378:metabolism; D019859:Proto-Oncogene Proteins c-met / Q000235:genetics*; D064030:S100 Calcium Binding Protein G / Q000378:metabolism; D015398:Signal Transduction / Q000235:genetics; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
C576511:Calb2 protein, mouse; D064032:Calbindin 2; D002135:Calcium-Binding Proteins; D010320:Parvalbumins; D064030:S100 Calcium Binding Protein G; D005680:gamma-Aminobutyric Acid; D019859:Proto-Oncogene Proteins c-met