Severe Japanese spotted fever successfully treated with fluoroquinolone.
A 77 years old woman who had a bite with eschar on her left arm, was admitted to emergency ward in our hospital, because of high fever, severe malaise, skin eruption, and consciousness disturbance beginning 5 days previously. She was diagnosed as Japanese spotted fever by seropositive of Rickettsia japonica (R. japonica) antibody, and successfully treated with fluoroquinolone, after minocycline hydrochloride had been proven ineffective. R. japonica-specific DNA was detected by PCR from the tick: Haemaphysalis hystricis larvae collected from a mountainous location in Fukuoka, Japan where the patient had been bitten.
Seki
Masafumi
M
Nagasaki University Graduate School of Biomedical Sciences, Department of Molecular Microbiology and Immunology, the Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan.
Ikari
Naruhiko
N
Yamamoto
Seigo
S
Yamagata
Yuhki
Y
Kosai
Kosuke
K
Yanagihara
Katsunori
K
Kakugawa
Tomoyuki
T
Kurihara
Shintaro
S
Izumikawa
Koichi
K
Miyazaki
Yoshitsugu
Y
Higashiyama
Yasuhito
Y
Hirakata
Yoichi
Y
Tashiro
Takayoshi
T
Kohno
Shigeru
S
D000368:Aged; D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D004269:DNA, Bacterial / Q000302:isolation & purification; D005260:Female; D024841:Fluoroquinolones / Q000627:therapeutic use*; D006801:Humans; D007564:Japan; D008911:Minocycline / Q000627:therapeutic use; D016133:Polymerase Chain Reaction; D019233:Retreatment; D012281:Rickettsia / Q000235:genetics; D012282:Rickettsia Infections / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology*; D012720:Severity of Illness Index; D013987:Ticks / Q000737:chemistry / Q000382:microbiology; D017211:Treatment Failure; D016896:Treatment Outcome
D000900:Anti-Bacterial Agents; D004269:DNA, Bacterial; D024841:Fluoroquinolones; D008911:Minocycline