title: Polymorphisms in genes related to bacterial lipopolysaccharide/peptidoglycan signaling and gastric precancerous lesions in a population at high risk for gastric cancer.
abstract: As Helicobacter pylori (HP) is a Gram-negative bacterium, we investigated the associations between several functional polymorphisms in genes involved in lipopolysaccharide (LPS) signaling and the prevalence of various stages of gastric premalignant lesions in a Venezuelan population. The two NOD2 polymorphisms, del3020insC and Gly908Arg, were too infrequent to study their associations with gastric lesions. The risk of intestinal metaplasia (IM) was significantly increased among subjects with the CD14 T-260 allele compared to those without this allele. A similar, but nonsignificant increase in risk for dysplasia was observed among homozygotes of this allele. There was no association between TLR4 Asp299Gly polymorphism and any type of lesions, except for a slight nonsignificant increase in risk of IM associated with the AA genotype among subjects with a higher histological HP score. These results suggest that genetic polymorphisms in HP LPS signaling may be implicated in the development of intermediate stages of gastric premalignant lesions.
authors.affiliation: Karmanos Cancer Institute, 110 East Warren Avenue, Detroit, Michigan 48201, USA. katoi@med.wayne.edu
authors.forename: Ikuko
authors.initials: I
authors.lastname: Kato
authors.forename: Federico
authors.initials: F
authors.lastname: Canzian
authors.forename: Martyn
authors.initials: M
authors.lastname: Plummer
authors.forename: Silvia
authors.initials: S
authors.lastname: Franceschi
authors.forename: Leen-Jan
authors.initials: LJ
authors.lastname: van Doorn
authors.forename: Jorge
authors.initials: J
authors.lastname: Vivas
authors.forename: Gladys
authors.initials: G
authors.lastname: Lopez
authors.forename: Yanhui
authors.initials: Y
authors.lastname: Lu
authors.forename: Lydie
authors.initials: L
authors.lastname: Gioia-Patricola
authors.forename: Richard K
authors.initials: RK
authors.lastname: Severson
authors.forename: Ann G
authors.initials: AG
authors.lastname: Schwartz
authors.forename: Nubia
authors.initials: N
authors.lastname: Muñoz
mesh_terms: D000328:Adult; D005260:Female; D005773:Gastroscopy; D005838:Genotype; D016481:Helicobacter Infections; D016480:Helicobacter pylori / Q000235:genetics*; D006801:Humans; D018950:Lipopolysaccharide Receptors / Q000235:genetics*; D008070:Lipopolysaccharides / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D053473:Nod2 Signaling Adaptor Protein / Q000378:metabolism*; D010457:Peptidoglycan / Q000378:metabolism*; D011110:Polymorphism, Genetic; D011230:Precancerous Conditions / Q000235:genetics*; D013274:Stomach Neoplasms / Q000453:epidemiology / Q000235:genetics* / Q000382:microbiology; D051197:Toll-Like Receptor 4 / Q000235:genetics*; D014687:Venezuela / Q000453:epidemiology
chemical_list: D018950:Lipopolysaccharide Receptors; D008070:Lipopolysaccharides; C429018:NOD2 protein, human; D053473:Nod2 Signaling Adaptor Protein; D010457:Peptidoglycan; C495345:TLR4 protein, human; D051197:Toll-Like Receptor 4