title: [Dyslipidemia and schizophrenia].
abstract: OBJECTIVE
  There is some evidence that the treatment with new ("atypical") neuroleptics is associated with a higher frequency of hyperlipidemia.
  
  
  OBJECTIVE
  In this study the serum lipid levels of patients with chronic schizophrenia were investigated.
  
  
  METHODS
  The serum lipid levels of 177 consecutively admitted schizophrenic patients treated at least 5 years were evaluated.
  
  
  RESULTS
  No gender differences of lipid concentrations could be detected. A considerable rate of the patients (35.6 %) showed elevated triglycerides (> 150 mg/dl) or elevated cholesterol levels (> 200 mg/dl; 43.9 %). The rate of patients with elevated cholesterol or triglyceride concentrations is associated with the duration of treatment. The comparison of different groups of neuroleptics yielded at best a trend to higher triglyceride levels in the patients treated with dibenzodiazepines compared to those receiving only classical neuroleptics. The triglyceride concentrations correlated with the body mass index (rho = 0.25, p < 0.01).
  
  
  CONCLUSIONS
  This study revealed evidence for an association of the rate of patients with elevated lipid levels and duration of neuroleptic treatment in schizophrenia patients.
authors.affiliation: Klinik für Psychiatrie und Psychotherapie, J.-W.-Goethe-Universität, Frankfurt/M. tilman.wetterling@vivantes.de
authors.forename: Tilman
authors.initials: T
authors.lastname: Wetterling
authors.forename: Barbara
authors.initials: B
authors.lastname: Schneider
authors.forename: Bernhard
authors.initials: B
authors.lastname: Weber
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D002784:Cholesterol / Q000097:blood; D002908:Chronic Disease; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood / Q000139:chemically induced*; D015228:Hypertriglyceridemia / Q000097:blood / Q000139:chemically induced*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D012559:Schizophrenia / Q000097:blood / Q000188:drug therapy*; D014280:Triglycerides / Q000097:blood
chemical_list: D014150:Antipsychotic Agents; D014280:Triglycerides; D002784:Cholesterol