[A new look at adipocyte lipid droplets: towards a role in the sensing of triacylglycerol stores?].
Lipid droplets have been considered for a long time as inert intracytoplasmic deposits formed within cells under various conditions. Recently, new tools and new approaches have been used to visualize and study these intracellular structures. This revealed new aspects of lipid droplets biology and pointed out their organized structure and dynamic composition. In adipocytes, the specialized cell type for the storage of energy as fat, lipid droplets are particularly well-developed organelles, and exhibit unique properties. Also discussed in this paper is the view that lipid droplets, through specific candidate constituents, can play a role in the sensing of the level of their lipid stores by adipocytes.
Blouin
Cédric
C
INSERM U671, Université Pierre et Marie Curie, Centre de Recherches Biomédicales des Cordeliers, 15, rue de l'ecole de médecine 75006 Paris, France.
Hajduch
Eric
E
Dugail
Isabelle
I
D017667:Adipocytes / Q000502:physiology* / Q000648:ultrastructure; D000273:Adipose Tissue / Q000502:physiology; D006801:Humans; D008954:Models, Biological; D015388:Organelles / Q000502:physiology / Q000648:ultrastructure; D010743:Phospholipids / Q000378:metabolism; D011506:Proteins / Q000502:physiology; D014280:Triglycerides / Q000378:metabolism*
D010743:Phospholipids; D011506:Proteins; D014280:Triglycerides