title: [Cardiomyocyte culture as a highly sensitive system for testing pharmacological activity of specific bradycardic agents].
abstract: Two antiarrhythmic agents were studied: verapamil and bradizole, a new bradycardic drug. It was found that both drugs exhibit a dose-dependent negative chronotropic effect on the culture of contractile cardiomyocytes of newborn rats. Bradizole showed more pronounced bradycardic properties than verapamil.
authors.forename: M E
authors.initials: ME
authors.lastname: Neverova
authors.forename: N A
authors.initials: NA
authors.lastname: Mkrtumova
authors.forename: O V
authors.initials: OV
authors.lastname: Fidelina
authors.forename: E I
authors.initials: EI
authors.lastname: Adamskaia
authors.forename: I B
authors.initials: IB
authors.lastname: Tsorin
authors.forename: G G
authors.initials: GG
authors.lastname: Chichkanov
authors.forename: L I
authors.initials: LI
authors.lastname: Chudakov
mesh_terms: D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology*; D001562:Benzimidazoles / Q000494:pharmacology*; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D002478:Cells, Cultured; D009200:Myocardial Contraction; D032383:Myocytes, Cardiac / Q000187:drug effects*; D051381:Rats; D013438:Sulfhydryl Compounds / Q000494:pharmacology*; D014700:Verapamil / Q000494:pharmacology*
chemical_list: C111159:2-(2-(diethylamino)ethyl)thio-5-ethoxybenzimidazole; D000889:Anti-Arrhythmia Agents; D001562:Benzimidazoles; D002121:Calcium Channel Blockers; D013438:Sulfhydryl Compounds; D014700:Verapamil