title: Blood pressure, fatigue, and the pathogenesis of aneurysmal subarachnoid hemorrhage.
abstract: BACKGROUND
  Endovascular embolization and BP reduction appear to protect cerebral aneurysms from rupture, although they do not totally eliminate aneurysm wall stress as does surgical clipping. We investigate the possible mechanisms of rupture to offer an explanation for this.
  
  
  METHODS
  Fatigue modeling of cerebral aneurysms using BP as the source of wall stress loading and calculating the increase in cycles to failure produced by a reduction in stress loading.
  
  
  RESULTS
  A modest reduction in the stress loading of aneurysms leads to a disproportionately large increase in the time taken for them to rupture. This result is based on the following assumptions and is thus restricted to aneurysm for which they may reasonably be true. Fatigue is the dominant mode of failure. The final decline in strength is rapid. The aneurysm lasts at least 6 weeks before rupturing.
  
  
  CONCLUSIONS
  A slight reduction in the stress on aneurysm walls can dramatically reduce their risk of rupture.
authors.affiliation: Neurosurgery (School of Surgical and Reproductive Sciences), Newcastle University, Newcastle General Hospital, NE4 6BE Newcastle upon Tyne, UK. patrick.mitchell@ncl.ac.uk
authors.forename: Patrick
authors.initials: P
authors.lastname: Mitchell
authors.forename: Danny
authors.initials: D
authors.lastname: Birchall
authors.forename: A David
authors.initials: AD
authors.lastname: Mendelow
mesh_terms: D017542:Aneurysm, Ruptured / Q000209:etiology / Q000503:physiopathology / Q000628:therapy; D018450:Disease Progression; D004621:Embolization, Therapeutic / Q000379:methods; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000503:physiopathology*; D002532:Intracranial Aneurysm / Q000150:complications / Q000453:epidemiology / Q000503:physiopathology; D008959:Models, Neurological; D018763:Muscle Fatigue; D009130:Muscle, Smooth / Q000503:physiopathology*; D013345:Subarachnoid Hemorrhage / Q000209:etiology / Q000503:physiopathology* / Q000628:therapy