Myofibroblastic sarcoma of the nasal cavity and paranasal sinus: a clinicopathologic study of 6 cases and review of the literature.
OBJECTIVE
We describe the clinicopathologic features of 6 cases of myofibroblastic sarcoma (MS) occurring in the nasal cavity and paranasal sinus.


METHODS
The paraffin-embedded tissues of 6 cases of MS were stained immunohistochemically and examined by electron microscopy.


RESULTS
Clinically, a painless enlarging mass was the most common symptom, followed by the nasal obstruction, epistaxis, copious rhinorrhea, and proptosis. Histologically, the tumors showed a diffusely infiltrative growth pattern and consisted mainly of spindle cells with abundant eosinophilic cytoplasm. The hypocellular myxoid areas and the hypercellular fibrous areas were identified. Immunohistochemically, all 6 tumors were positive for vimentin, alpha-smooth muscle actin, calponin, and fibronectin. Ultrastructural examination in 3 cases showed characteristic features of myofibroblast. Follow-up in 6 patients revealed high local recurrence rate (6 out of 6).


CONCLUSIONS
Myofibroblastic sarcoma of the nasal cavity and paranasal sinus exhibit diverse histologic appearances and a strong aggressive behavior.
Meng
Guo-Zhao
GZ
Department of Pathology and Laboratory of Pathology, West China Hospital, Zichuan University, Chengdu City, PR China
Zhang
Hong-Ying
HY
Bu
Hong
H
Yang
Guang-Hua
GH
Zhang
Xian-Liang
XL
Yang
Guo
G
D000199:Actins / Q000032:analysis; D000293:Adolescent; D000328:Adult; D000368:Aged; D002135:Calcium-Binding Proteins / Q000032:analysis; D017809:Fatal Outcome; D005260:Female; D005353:Fibronectins / Q000032:analysis; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008840:Microfilament Proteins / Q000032:analysis; D008875:Middle Aged; D009217:Myosarcoma / Q000737:chemistry / Q000473:pathology* / Q000648:ultrastructure; D009361:Neoplasm Invasiveness; D009669:Nose Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000648:ultrastructure; D010255:Paranasal Sinus Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000648:ultrastructure; D014746:Vimentin / Q000032:analysis; D000096985:Calponins
D000199:Actins; D002135:Calcium-Binding Proteins; D005353:Fibronectins; D008840:Microfilament Proteins; D014746:Vimentin; D000096985:Calponins