Virological characterization of an infection with a dual-tropic, multidrug-resistant HIV-1 and further evolution on antiretroviral therapy.
We studied a case of recent infection with multidrug-resistant (MDR) HIV-1. Over 16 months off-therapy, the CD4 cell count decreased from 419 to 184 cells/mul. Antiretroviral therapy (ART) then led to an incomplete virological response but to an immunological benefit, concurrently with a shift to CCR5-only tropism and a reduction in replication capacity. ART, even if suboptimal, can be of interest in the case of MDR virus infection.
Masquelier
Bernard
B
Department of Virologie et Immunologie Biologique, CHU de Bordeaux, Bordeaux, France.
Capdepont
Sophie
S
Neau
Didier
D
Peuchant
Olivia
O
Taupin
Jean-Luc
JL
Coakley
Eoin
E
Lie
Yolanda
Y
Carpentier
Wassila
W
Dabis
François
F
Fleury
Hervé J A
HJ
D000328:Adult; D044966:Anti-Retroviral Agents / Q000627:therapeutic use*; D018791:CD4 Lymphocyte Count; D024921:Drug Resistance, Multiple, Viral; D005838:Genotype; D015658:HIV Infections / Q000188:drug therapy* / Q000276:immunology / Q000821:virology; D015497:HIV-1 / Q000235:genetics; D006801:Humans; D008297:Male; D019713:Receptors, CCR5 / Q000378:metabolism; D019562:Viral Load
D044966:Anti-Retroviral Agents; D019713:Receptors, CCR5