title: [Meta-analysis of association of deletion allele of angiotensin-converting enzyme gene with coronary heart disease in China].
abstract: OBJECTIVE
  To qualitatively and quantitatively assess the evidence regarding the relation of ACE I/D polymorphism to coronary heart disease (CHD) risk.
  
  
  METHODS
  Medline (January 1994 to February 2005) and China Hospital Knowledge Databases (January 1994 to May 2005) were retrieved for all publications relating to case-control studies reporting a link between CHD risk factors and the ACE I/D polymorphism. All 16 association studies were identified and a meta-analysis was conducted by using the RevMan 4.2 estimate for odds ratio (OR) to determine whether the DD genotype might predict the outcome in CHD.
  
  
  RESULTS
  Sixteen out of 48 identified studies reporting data on 1345 CHD patients and 1286 matched controls fulfilled these inclusion criteria. The overall distribution of genotypes in the control subjects was 35.88% II, 40.86% ID, and 23.26% DD. The odds ratio for CHD for DD versus ID/II genotypes across all studies was 2.56 [95% CI, 2.09 - 3.13]. The relative CHD risk appeared to be increased with the D allele (chi(Trend)(2) = 97.12, P < 0.01).
  
  
  CONCLUSIONS
  ACE gene I/D polymorphism should be associated with susceptivity of coronary heart disease in China. The CHD risk is increased significantly in individuals with DD genotypes. The ACE D allele should be a risk factor for CHD.
authors.affiliation: Departmant of Cardiology, Jinan University 2nd Medical College, Shenzhen 518020, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Jiang
authors.forename: Shao-hong
authors.initials: SH
authors.lastname: Dong
authors.forename: Lin-jie
authors.initials: LJ
authors.lastname: Luo
authors.forename: Yi
authors.initials: Y
authors.lastname: Sun
authors.forename: Yu-hua
authors.initials: YH
authors.lastname: Liao
mesh_terms: D000483:Alleles; D002681:China; D003327:Coronary Disease / Q000235:genetics*; D017353:Gene Deletion; D020022:Genetic Predisposition to Disease; D006801:Humans; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length
chemical_list: D007703:Peptidyl-Dipeptidase A