title: Pyrimido[4,5-d]pyrimidine-2,4,5,7-(1H, 3H, 6H, 8H)-tetraone as a novel universal base.
abstract: A derivative of pyrimido[4,5-d]pyrimidine-2,4,5,7-(1H,3H,6H,8H)-tetraone (PPT), which may form various keto-enol tautomers suitable for forming base pairs with all natural bases, and is thus expected to serve as a universal base, was synthesized. The ability of PPT to form base pairs with natural bases was evaluated by UV analysis.
authors.affiliation: Research Center for Computational Science, National Institutes for Natural Sciences, Okazaki 444-8787, Japan.
authors.forename: Masanori
authors.initials: M
authors.lastname: Kataoka
authors.forename: Taisuke
authors.initials: T
authors.lastname: Hirano
authors.forename: Kenji
authors.initials: K
authors.lastname: Kuroda
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Hayakawa
mesh_terms: D020029:Base Pairing; D006860:Hydrogen Bonding; D011744:Pyrimidinones / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: C520195:1-(2-tert-butyldiphenylsiloxyethyl)pyrimido(4,5-d)pyrimidine-2,4,55,7-(1H,3H,6H,8H)-tetraone; D011744:Pyrimidinones; C520194:pyrimido(4,5-d)pyrimidine-2,4,5,7-(1H,3H,6H,8H)-tetraone