title: Ultra heat treatment destroys cholesterol-lowering effect of soy protein.
abstract: A randomized, placebo-controlled, double-blind clinical study was performed to investigate the dose-dependent response of serum cholesterol after consuming an ultra-heat-treated milk containing a soy protein preparation. Eighty hypercholesterolemic subjects were assigned to one of four study groups receiving 12.5 or 25 g soy protein (active treatment) or casein (placebo) daily over a period of 4 weeks. The trial substances were provided as ready-made, ultra-heated milk preparations. Before and after the treatment, serum concentrations of total, low-density lipoprotein, and high-density lipoprotein cholesterol were determined. Unexpectedly, at the end of the study, low-density lipoprotein cholesterol concentrations were significantly increased compared with baseline in all study groups. The magnitude of this increase (17-19%) was similar in all active and placebo study groups. Soy protein supplements previously shown to be effective in reducing serum cholesterol had in this study no such lipid-lowering effect after ultra heat treatment.
authors.affiliation: Karolinska Institute, Stockholm, Sweden. hoie@nutripharma.com
authors.forename: Lars H
authors.initials: LH
authors.lastname: Hoie
authors.forename: Ake
authors.initials: A
authors.lastname: Sjoholm
authors.forename: Marie
authors.initials: M
authors.lastname: Guldstrand
authors.forename: Hans-Joachim F
authors.initials: HJ
authors.lastname: Zunft
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Lueder
authors.forename: Hans-Joachim
authors.initials: HJ
authors.lastname: Graubaum
authors.forename: Joerg
authors.initials: J
authors.lastname: Gruenwald
mesh_terms: D000328:Adult; D000368:Aged; D001628:Beverages; D002364:Caseins / Q000378:metabolism; D002784:Cholesterol / Q000097:blood*; D019587:Dietary Supplements; D004311:Double-Blind Method; D005260:Female; D005511:Food Handling / Q000379:methods*; D006358:Hot Temperature / Q000009:adverse effects*; D006801:Humans; D006937:Hypercholesterolemia / Q000178:diet therapy*; D008075:Lipoproteins, HDL / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male; D008875:Middle Aged; D010840:Phytosterols / Q000378:metabolism; D030262:Soybean Proteins / Q000378:metabolism*; D013025:Glycine max; D017211:Treatment Failure
chemical_list: D002364:Caseins; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D010840:Phytosterols; D030262:Soybean Proteins; D002784:Cholesterol