title: Antigen presentation by B lymphocytes: how receptor signaling directs membrane trafficking.
abstract: Antigen capture and presentation onto MHC class II molecules by B lymphocytes is mediated by their surface antigen receptor - the B-cell receptor (BCR). The BCR must therefore coordinate the transport of MHC class II- and antigen-containing vesicles for them to converge and ensure efficient processing. Recently, progress has been made in understanding which and how these vesicular transport events are molecularly linked to BCR signaling. In particular, recent studies have emphasized the key roles of membrane microdomains and the actin cytoskeleton in regulation of membrane trafficking upon BCR engagement.
authors.affiliation: Unité Inserm 653, Institut Curie, 12 rue Lhomond, 75005, Paris, France.
authors.forename: Fulvia
authors.initials: F
authors.lastname: Vascotto
authors.forename: Delphine
authors.initials: D
authors.lastname: Le Roux
authors.forename: Danielle
authors.initials: D
authors.lastname: Lankar
authors.forename: Gabrielle
authors.initials: G
authors.lastname: Faure-André
authors.forename: Pablo
authors.initials: P
authors.lastname: Vargas
authors.forename: Pierre
authors.initials: P
authors.lastname: Guermonprez
authors.forename: Ana-Maria
authors.initials: AM
authors.lastname: Lennon-Duménil
mesh_terms: D017951:Antigen Presentation / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D001693:Biological Transport, Active / Q000276:immunology; D002462:Cell Membrane / Q000276:immunology* / Q000378:metabolism; D011947:Receptors, Antigen, B-Cell / Q000502:physiology*; D015398:Signal Transduction / Q000276:immunology*
chemical_list: D011947:Receptors, Antigen, B-Cell