Comprehensive association analysis of the NOS2A gene with Parkinson disease.
Inducible nitric oxide synthase (NOS2A) may be involved in the oxidative stress pathology of Parkinson disease (PD). Two previous studies reported an association of a single nucleotide polymorphism (rs1060826) with PD. A replication study of 340 German patients and 680 controls showed no significant association between 12 genotyped polymorphisms and PD. NOS2A is therefore not a major susceptibility locus in our relatively young sample population.
Schulte
C
C
Hertie-Institute for Clinical Brain Research, Section for Neurodegenerative Diseases, University of Tübingen, Hoppe-Seyler Str. 3, 72076 Tübingen, Germany.
Sharma
M
M
Mueller
J C
JC
Lichtner
P
P
Prestel
J
J
Berg
D
D
Gasser
T
T
D000483:Alleles; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006801:Humans; D015810:Linkage Disequilibrium / Q000235:genetics; D018895:Microsatellite Repeats / Q000235:genetics; D008875:Middle Aged; D052247:Nitric Oxide Synthase Type II / Q000235:genetics*; D010300:Parkinson Disease / Q000201:enzymology* / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics
C496319:NOS2 protein, human; D052247:Nitric Oxide Synthase Type II