Synthesis of 5''-substituted cyclic ADP-carbocyclic-ribose as biological tools.
5''-Branched cyclic ADP-carbocyclic-riboses (4 and 5) were designed as biological tools for identifying the target proteins of cyclic ADP-ribose, an intracellular Ca(2+)-mobilizing second messenger. One of the targets, 4, successfully synthesized.
Sakaguchi
Natsumi
N
Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo 060-0812, Japan.
Kudoh
Takashi
T
Murayama
Takashi
T
Arisawa
Mitsuhiro
M
Matsuda
Akira
A
Shuto
Satoshi
S
D000241:Adenosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D001952:Bridged-Ring Compounds / Q000138:chemical synthesis / Q000737:chemistry; D020013:Calcium Signaling
D001952:Bridged-Ring Compounds; D000241:Adenosine