Surface modification of poly(oligoethylene oxide methacrylate) for resisting protein adsorption.
We prepare poly(2-methoxyethyl-, 2-(2-methoxyethoxy)ethyl-, 2-[2-(2-methoxyethoxy)ethoxy]ethyl methacrylate) (p(nEOMA), n=1, 2, and 3) brushed surfaces with varying the polymer density by surface initiated polymerization. The amount of bovine serum albumin (BSA) adsorbed on the surfaces is investigated. The mobility of the polymer chain in the polymer/water interfaces and the structure of adsorbed water on the surfaces are characterized by Electron Spin Resonance (ESR) and transmission-Fourier transform infrared (FT-IR) spectroscopy, respectively. This work reports the relationship between these surface properties and albumin adsorption. As a result, the surface having both a high molecular mobility and bulk-like water found to be very effective in preventing albumin adsorption.
Tsukagoshi
Tatsuya
T
Department of Industrial Chemistry, Faculty of Engineering, Tokyo University of Science, 12-1 Ichigaya-Funagawara, Shinjuku-ku, Tokyo 162-0826, Japan.
Kondo
Yukishige
Y
Yoshino
Norio
N
D000327:Adsorption; D000818:Animals; D002417:Cattle; D004578:Electron Spin Resonance Spectroscopy; D008689:Methacrylates / Q000737:chemistry*; D015394:Molecular Structure; D011092:Polyethylene Glycols / Q000737:chemistry*; D012710:Serum Albumin, Bovine / Q000737:chemistry*; D012822:Silicon Dioxide / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared; D013499:Surface Properties; D014867:Water / Q000737:chemistry
D008689:Methacrylates; C517620:poly(oligoethylene oxide methacrylate); D014867:Water; D012710:Serum Albumin, Bovine; D011092:Polyethylene Glycols; D012822:Silicon Dioxide