title: [Induratio penis plastica--localized or diffusive fibromatosis of tunica albuginea penis?].
abstract: OBJECTIVE
  The part of the tunica albuginea that is not affected by localized pathological fibrosis is excised by the Nesbit contralateral excisional corporalplasty in patients with induratio penis plastica (IPP). The aim of this study was to find out if there were any histological changes of the macroscopically normal tunica albuginea excised during the Nesbit corporalplasty.
  
  
  METHODS
  A total of 31 patients, mean age 45 +/- 7.65 years, were surgical treated for extensive penile curvature (impossible or difficult penile imission in the vagina), using the Nesbit surgical technique. The tunica albuginea tissue was manipulated by Allis's clamps and excised in the shape of a diamond and placed in the 4% formaldehyde solution for histological analysis. The excised tunica albuginea was not wider than 1 cm, while the histological preparations were 3 to 5 microm thick, and they were stained with hematoxylin-eosin. The excised tunica albuginea tissue appeared macroscopically (anatomically) normal in all of the operated patients. In 28 (90.3%) patients opperated for dorsal curvature of the penis, the tissue of the tunica albuginea was excised from the urethral ridge, while in 3 (9.7%) patients operated for lateral curvature, the tissue was excised from the lateral corpus cavernosum.
  
  
  RESULTS
  The histological results were normal in 12 (38.7%) patients, while in 19 (61.3%) cases the findings indicated fibrosis of tunica albuginea. No significant difference in the patients age was found between these two groups (p = 0.09). The analysis of a total number of histological results of the patients with tunica albuginea fibrosis in relation to the patients with normal results showed that there was no significant difference (chi2 = 1,2; df = 1; p > 0.05), suggesting that the macroscopically normal tunica albuginea is not always expected to yield normal histological result.
  
  
  CONCLUSIONS
  Significantly more reported histological results of tunica albuginea fibrosis in the location that appeared normal macroscopically (chi2 = 27.5; df = 1; p < 0.01) indicated that, in the majority of IPP patients (61.3%), pathological lesion was diffusive with localized phenotypic expression plaque in the tunica albuginea, showing that, in the majority of cases noxa acted diffusely.
authors.affiliation: Institut za urologiju i nefrologiju, Klinicki centar Srbije, Beograd.
authors.forename: Dorde
authors.initials: D
authors.lastname: Nale
authors.forename: Sava
authors.initials: S
authors.lastname: Mićić
authors.forename: Ivan
authors.initials: I
authors.lastname: Vuković
authors.forename: Radoslav
authors.initials: R
authors.lastname: Radosavljević
mesh_terms: D005355:Fibrosis; D006801:Humans; D008297:Male; D008875:Middle Aged; D010411:Penile Induration / Q000473:pathology* / Q000601:surgery; D010413:Penis / Q000473:pathology* / Q000601:surgery; D013519:Urogenital Surgical Procedures / Q000379:methods