Heart rate and spectral EEG changes accompanying periodic and non-periodic leg movements during sleep.
OBJECTIVE
To evaluate the changes in heart rate (HR) and EEG spectra accompanying periodic (PLM) and non-periodic leg movements (NPLM) during sleep in patients with restless legs syndrome (RLS).


METHODS
Sixteen patients with RLS underwent one polysomnographic night recording; leg movements (LMs) during sleep were detected and classified as PLM or NPLM; up to 10 PLM and NPLM were chosen from NREM and REM sleep, for each patient and for each type (mono- or bilateral). EEG spectral analysis and HR were evaluated for 20s preceding and 30s following the onset of each LM.


RESULTS
EEG activation preceded LMs, particularly in the delta band which increased before the other frequency bands, in NREM sleep but not in REM sleep for PLM, and in both stages for NPLM. A similar difference was seen between mono- and bilateral LMs.


CONCLUSIONS
Sleep EEG, HR, and leg motor activity seems to be modulated by a complex dynamically interacting system of cortical and subcortical mechanisms, which influence each other.


CONCLUSIONS
Future studies on the clinical significance of leg motor events during sleep need to take into account events classifiable as "isolated" and to integrate the autonomic and EEG changes accompanying them.
Ferri
Raffaele
R
Sleep Research Centre, Department of Neurology I.C., Oasi Institute (IRCCS), 94018 Troina, Italy. rferri@oasi.en.it
Zucconi
Marco
M
Rundo
Francesco
F
Spruyt
Karen
K
Manconi
Mauro
M
Ferini-Strambi
Luigi
L
D001341:Autonomic Nervous System / Q000503:physiopathology; D004569:Electroencephalography / Q000379:methods*; D005071:Evoked Potentials; D005260:Female; D006339:Heart Rate; D006801:Humans; D007866:Leg / Q000294:innervation / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000294:innervation / Q000503:physiopathology; D010507:Periodicity; D017286:Polysomnography / Q000379:methods; D012148:Restless Legs Syndrome / Q000503:physiopathology*; D012890:Sleep