title: Cognitive phenotypes in temporal lobe epilepsy.
abstract: The objective of this study is to determine if distinct cognitive phenotypes could be identified in temporal lobe epilepsy. Epilepsy patients (n = 96) and healthy controls (n = 82) underwent comprehensive neuropsychological assessment. Adjusted (age, gender, and education) test scores for epilepsy subjects were grouped into cognitive domains (intelligence, language, visuoperception, immediate and delayed memory, executive function, and cognitive/psychomotor speed). Cluster analysis revealed three distinct cognitive profiles types: (1) minimally impaired (47% of subjects); (2) memory impaired (24%); and (3) memory, executive, and speed impaired (29%). The three cluster groups exhibited different patterns of results on demographic, clinical epilepsy, brain volumetrics, and cognitive course over a 4-year interval. The specific profile characteristics of the identified cognitive phenotypes are presented and their implications for the investigation of the neurobehavioral complications of epilepsy are discussed.
authors.affiliation: Department of Neurology, University of Wisconsin-Madison, Madison, Wisconsin 53792, USA. hermann@neurology.wisc.edu
authors.forename: Bruce
authors.initials: B
authors.lastname: Hermann
authors.forename: Michael
authors.initials: M
authors.lastname: Seidenberg
authors.forename: Eun-Jeong
authors.initials: EJ
authors.lastname: Lee
authors.forename: Fong
authors.initials: F
authors.lastname: Chan
authors.forename: Paul
authors.initials: P
authors.lastname: Rutecki
mesh_terms: D000293:Adolescent; D000328:Adult; D002908:Chronic Disease; D003072:Cognition Disorders / Q000145:classification* / Q000175:diagnosis / Q000453:epidemiology*; D004833:Epilepsy, Temporal Lobe / Q000175:diagnosis / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index; D013702:Temporal Lobe / Q000473:pathology; D014888:Wechsler Scales