Effects of diesel exhaust particles on human neutrophil activation.
Diesel exhaust particles (DEP) are associated with respiratory disease and exposure to diesel exhaust induces an inflammatory response associated with marked leukocytic infiltration in the lung. This study examined whether neutrophils are activated by the active component of DEP (methanol extract of DEP [me-DEP]). The authors demonstrated that neutrophils exposed to me-DEP had increased levels of the f-actin content, the surface expression of adhesion molecules, and the release of interleukin (IL-8) and leukotriene B4 (LTB4), superoxide, and matrix metalloproteinase (MMP-9). Thus, the author conclude that DEP exposure activates neutrophils and that these activated neutrophils could contribute to the adverse respiratory health effects associated with DEP and to the pathogenesis of chronic inflammatory lung diseases.
Matsuzaki
Tatsu
T
Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan.
Amakawa
Kazuhisa
K
Yamaguchi
Kazuhiro
K
Ishizaka
Akitoshi
A
Terashima
Takeshi
T
Matsumaru
Akiko
A
Morishita
Tetsuo
T
D000199:Actins / Q000378:metabolism; D000328:Adult; D000393:Air Pollutants / Q000633:toxicity*; D039481:CD11b Antigen / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D006861:Hydrogen Peroxide / Q000378:metabolism; D016209:Interleukin-8 / Q000378:metabolism; D007975:Leukotriene B4 / Q000378:metabolism; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000378:metabolism; D018375:Neutrophil Activation / Q000187:drug effects* / Q000276:immunology; D009504:Neutrophils / Q000187:drug effects* / Q000276:immunology / Q000473:pathology; D001335:Vehicle Emissions / Q000633:toxicity*
D000199:Actins; D000393:Air Pollutants; D039481:CD11b Antigen; D016209:Interleukin-8; D001335:Vehicle Emissions; D007975:Leukotriene B4; D006861:Hydrogen Peroxide; D020780:Matrix Metalloproteinase 9