title: The speed of lexical activation is altered in Parkinson's disease.
abstract: Disturbed comprehension of complex noncanonical sentences in Parkinson's disease (PD) has been linked to dopamine depletion and delayed lexical retrieval. The aim of the present study was to replicate findings of delayed lexical activation in PD patients with noncanonical sentence processing difficulties, and investigate the influence of dopamine depletion on these changes to lexical access. In the first experiment, 20 patients with PD (tested whilst 'on' dopaminergic medication) and 23 controls participated in a list priming experiment. In this paradigm, stimuli are presented as a continuous list of words/nonwords, and semantic priming effects were measured across inter-stimulus intervals (ISIs) of 500 ms, 1000 ms and 1500 ms, with data analyzed using multivariate analyses of variance. The results revealed longer delays in lexical activation for PD patients with poor comprehension of noncanonical sentences, suggesting that the speed of lexical access may be compromised in PD, and that this feature may contribute to certain sentencecomprehension difficulties. In the second experiment, 7 patients with PD who participated in the first experiment, performed the same lexical decision task while 'off' their dopaminergic medication. Semantic priming effects were measured across ISIs of 500 ms and 1500 ms. Within group comparisons revealed a different pattern of semantic priming for the PD patients when 'on' compared to 'off' medication, providing further support for a dopaminergic influence on the speed of information processing and lexical activation.
authors.affiliation: Centre for Research in Language Processing and Linguistics, The University of Queensland, Brisbane, Australia.
authors.forename: Anthony J
authors.initials: AJ
authors.lastname: Angwin
authors.forename: Helen J
authors.initials: HJ
authors.lastname: Chenery
authors.forename: David A
authors.initials: DA
authors.lastname: Copland
authors.forename: Bruce E
authors.initials: BE
authors.lastname: Murdoch
authors.forename: Peter A
authors.initials: PA
authors.lastname: Silburn
mesh_terms: D000161:Acoustic Stimulation / Q000379:methods; D000368:Aged; D016022:Case-Control Studies; D032882:Comprehension / Q000187:drug effects / Q000502:physiology*; D015259:Dopamine Agents / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007980:Levodopa / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010153:Paired-Associate Learning / Q000187:drug effects / Q000502:physiology*; D010300:Parkinson Disease / Q000188:drug therapy / Q000503:physiopathology*; D011930:Reaction Time / Q000187:drug effects / Q000502:physiology*; D012660:Semantics; D013997:Time Factors
chemical_list: D015259:Dopamine Agents; D007980:Levodopa