Modifying the anti-inflammatory effects of high-density lipoprotein.
The anti-inflammatory effects of high-density lipoproteins (HDL) are well documented and include inhibition of low-density lipoprotein (LDL) oxidation, reduction of inflammatory cytokines and vascular leukocyte adhesion molecules, and participation in innate immunity. However, certain conditions, including coronary disease, diabetes mellitus, systemic inflammation, and a diet high in saturated fat, are associated with modification of HDL such that it paradoxically enhances LDL oxidation and/or vascular inflammation. Treatment with statins and/or apolipoprotein A1 mimetic peptides improves HDL's anti-inflammatory functions, and these as well as other medications may represent a novel pathway through which to target atherosclerosis.
Ansell
Benjamin J
BJ
Department of Medicine, David Geffen School of Medicine at UCLA, 100 UCLA Medical Plaza, Suite 525, Los Angeles, CA 90095, USA. bansell@mednet.ucla.edu
Fonarow
Gregg C
GC
Navab
Mohamad
M
Fogelman
Alan M
AM
D006801:Humans; D007249:Inflammation / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control; D018836:Inflammation Mediators / Q000502:physiology*; D008075:Lipoproteins, HDL / Q000009:adverse effects / Q000502:physiology*
D018836:Inflammation Mediators; D008075:Lipoproteins, HDL