title: [The influence of aging on pathologic and immunobiologic parameters of invasive ductal breast carcinoma].
abstract: OBJECTIVE
  Most human cancers, including breast one, increase in frequency with aging. The aim of this study was to explore the hypothesis that aging also alters breast cancer biology.
  
  
  METHODS
  The study included 120 women with primary invasive ductal carcinoma of the breast. We correlated the patients age and diagnosis with the commonly used clinical, pathological factors and newer tumor biomarkers. Immunohistochemical staining was conducted for p53, c-erbB-2, Ki-67, estrogen (ER), progesterone (PR) receptors, and angiogenesis.
  
  
  RESULTS
  In our study, the patients with axillary lymph node metastases and negative steroid hormone receptors (ER and PR) were significantly younger than the patients with nodal involvement and positive hormone receptors. There was also a significant association between the patients age, diagnosis and angiogenesis. No association was found between the patients age and tumour size, histological grade, p53, c-erbB-2, and Ki-67.
  
  
  CONCLUSIONS
  The results of our study supported only partially the hypothesis that the breast cancer biology is significantly affected by a patient's age.
authors.affiliation: Odeljenje za patologiju i citodijagnostiku, Institut za onkologiju Sremska Kamenica. kapicl@Eunet.yu
authors.forename: Tatjana
authors.initials: T
authors.lastname: Ivković-Kapicl
authors.forename: Slavica
authors.initials: S
authors.lastname: Knezević-Usaj
authors.forename: Milana
authors.initials: M
authors.lastname: Panjković
authors.forename: Dejan
authors.initials: D
authors.lastname: Nincić
authors.forename: Katarina
authors.initials: K
authors.lastname: Mastilović
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging; D014408:Biomarkers, Tumor / Q000032:analysis; D001943:Breast Neoplasms / Q000378:metabolism / Q000473:pathology*; D018270:Carcinoma, Ductal, Breast / Q000378:metabolism / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008207:Lymphatic Metastasis; D008875:Middle Aged; D011960:Receptors, Estrogen / Q000032:analysis; D011980:Receptors, Progesterone / Q000032:analysis
chemical_list: D014408:Biomarkers, Tumor; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone