Investigating biological activity spectrum for novel quinoline analogues.
The lack of the wide spectrum of biological data is an important obstacle preventing the efficient molecular design. Quinoline derivatives are known to exhibit a variety of biological effects. In the current publication, we tested a series of novel quinoline analogues for their photosynthesis-inhibiting activity (the inhibition of photosynthetic electron transport in spinach chloroplasts (Spinacia oleracea L.) and the reduction of chlorophyll content in Chlorella vulgaris Beij.). Moreover, antiproliferative activity was measured using SK-N-MC neuroepithelioma cell line. We described the structure-activity relationships (SAR) between the chemical structure and biological effects of the synthesized compounds. We also measured the lipophilicity of the novel compounds by means of the RP-HPLC and illustrate the relationships between the RP-HPLC retention parameter logK (the logarithm of capacity factor K) and logP data calculated by available programs.
Musiol
Robert
R
Institute of Chemistry, University of Silesia, Szkolna 9, 40007 Katowice, Poland.
Jampilek
Josef
J
Kralova
Katarina
K
Richardson
Des R
DR
Kalinowski
Danuta
D
Podeszwa
Barbara
B
Finster
Jacek
J
Niedbala
Halina
H
Palka
Anna
A
Polanski
Jaroslaw
J
D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects; D048408:Chlorella vulgaris / Q000187:drug effects*; D002734:Chlorophyll; D002736:Chloroplasts / Q000187:drug effects*; D002851:Chromatography, High Pressure Liquid; D004579:Electron Transport / Q000187:drug effects; D006801:Humans; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D018241:Neuroectodermal Tumors, Primitive, Peripheral / Q000188:drug therapy; D010788:Photosynthesis / Q000187:drug effects; D011804:Quinolines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D018724:Spinacia oleracea / Q000187:drug effects*; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
D000935:Antifungal Agents; D000970:Antineoplastic Agents; D011804:Quinolines; D002734:Chlorophyll