Sugar modification as a means to increase the biological performance of oligonucleotides.
Modification of the ribose unit in DNA and RNA profoundly influences the self-rcognition and the biological properties of the nucleic acids. Conformational restriction of the ribose units, as in LNA and tricyclo-DNA, has been identified as a powerful tool to increase DNA and RNA affinity as well as biological stability and antisense properties. Apart from that sugar modified DNA analogues, as homo-DNA, have shown to be orthogonal base-pairing systems which by virtue of non-crosscommunicating with the natural nucleic acids open novel applications in biotechnology.
Leumann
Christian J
CJ
Department of Chemistry & Biochemistry, University of Bern, Freiestrasse 3, CH-3012 Bern, Switzerland.
D015342:DNA Probes / Q000737:chemistry; D009838:Oligodeoxyribonucleotides / Q000737:chemistry*; D020319:Oligodeoxyribonucleotides, Antisense / Q000737:chemistry; D012266:Ribose / Q000737:chemistry*
D015342:DNA Probes; D009838:Oligodeoxyribonucleotides; D020319:Oligodeoxyribonucleotides, Antisense; D012266:Ribose