Erythrocyte-derived epoxyeicosatrienoic acids.
Red blood cells (RBCs) are reservoirs for cis- and trans-epoxyeicosatrienoic acids (EETs) that can be released. The sources of EET release from RBCs include direct synthesis from arachidonic acid, peroxidation of phospholipids and EETs esterified into cellular phospholipids. The release of EETs from RBCs can be through cytosolic phospholipase A2 (PLA2), secretory PLA2 and other responses associated with ATP release from RBCs. The erythrocyte ATP, purinergic receptors, ATP-binding cassette transporters, PLA2 and cytoskeleton rearrangement may all participate in EET release in the microcirculatory deformation of RBCs. EETs are vasodilatory and are candidate endothelium-derived hyperpolarizing factors. Due to the anti-hypertensive, fibrinolytic, and anti-thrombotic properties of EETs, their release from RBCs is replete with implications for the control of circulation and rheological characteristics of the circulating blood.
Jiang
Houli
H
Department of Pharmacology, New York Medical College, Valhalla, New York 10595, USA. houli.jiang@nymc.edu
D015126:8,11,14-Eicosatrienoic Acid / Q000031:analogs & derivatives* / Q000097:blood; D000255:Adenosine Triphosphate / Q000097:blood; D000818:Animals; D016718:Arachidonic Acid / Q000097:blood; D004852:Epoxy Compounds / Q000097:blood; D004912:Erythrocytes / Q000378:metabolism*; D006801:Humans; D008833:Microcirculation / Q000502:physiology; D010741:Phospholipases A / Q000378:metabolism; D054467:Phospholipases A2; D018048:Receptors, Purinergic P2 / Q000502:physiology; D058486:Receptors, Purinergic P2X7
D004852:Epoxy Compounds; C546468:P2RX7 protein, human; D018048:Receptors, Purinergic P2; D058486:Receptors, Purinergic P2X7; D016718:Arachidonic Acid; D000255:Adenosine Triphosphate; D010741:Phospholipases A; D054467:Phospholipases A2; D015126:8,11,14-Eicosatrienoic Acid