Anti-SARS-CoV activity of nucleoside analogs having 6-chloropurine as a nucleobase.
Nucleoside analogs that have 6-chloropurine as a nucleobase were synthesized and evaluated to develop novel anti-SARS-CoV agents. Two compounds among them showed promising activity that was comparable to mizoribine and ribavirin. Moreover, one of the compounds showed a structurally unique property.
Ikejiri
Masahiro
M
Faculty of Pharmaceutical Sciences at Kagawa Campus, Tokushima Bunri University, 1314-1 Shido, Sanuki, Kagawa 769-2193, Japan.
Saijo
Masayuki
M
Morikawa
Shigeru
S
Fukushi
Shuetsu
S
Mizutani
Tetsuya
T
Kurane
Ichiro
I
Maruyama
Tokumi
T
D000998:Antiviral Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D011684:Purine Nucleosides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D011687:Purines / Q000737:chemistry*; D045473:Severe acute respiratory syndrome-related coronavirus / Q000187:drug effects* / Q000254:growth & development; D010948:Viral Plaque Assay
D000998:Antiviral Agents; D011684:Purine Nucleosides; D011687:Purines; C079308:6-chloropurine