title: Case report: Cystoscopic use of cyanoacrylate glue for bleeding during transurethral resection of bladder tumors.
abstract: An 81-year-old woman with a history of nephroureterectomy and bladder cuff excision for grade 3 stage pT3N0M0 transitional-cell neoplasia presented with three bladder neoplasms. She also had symptomatic varicose veins in the lower extremities and received low-molecular-weight heparin. During transurethral resection of the tumors, deep ablation of the base of one lesion resulted in significant arterial bleeding that could not be controlled with normal endoscopic techniques. On the basis of previous positive experience, we endoscopically injected 3 mL of cyanoacrylate glue (Glubran 2) deeply (5 mm) into the tissue surrounding the bleeding site, making four injections with a device used for collagen injections. The area was irrigated with mannitol and sorbitol, and within a few seconds, there was complete remission of bleeding. We waited a further 90 seconds with the bladder distended to allow the substance to lose its adhesive properties so as to avoid having the bladder walls stick together. The catheter was removed on the third day, with resumption of micturition and clear urine. This appears to be the first case of cystoscopic use of cyanoacrylate glue to control bleeding.
authors.affiliation: Urology Unit, Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy. luca.carmignani@unimi.it
authors.forename: Luca
authors.initials: L
authors.lastname: Carmignani
authors.forename: Pietro
authors.initials: P
authors.lastname: Acquati
authors.forename: Francesco
authors.initials: F
authors.lastname: Rocco
mesh_terms: D000269:Adhesives / Q000627:therapeutic use*; D000369:Aged, 80 and over; D000925:Anticoagulants / Q000009:adverse effects; D002295:Carcinoma, Transitional Cell / Q000150:complications / Q000601:surgery*; D003487:Cyanoacrylates / Q000627:therapeutic use*; D015653:Cystectomy / Q000009:adverse effects; D003558:Cystoscopy; D005260:Female; D006801:Humans; D007866:Leg / Q000098:blood supply; D017762:Nadroparin / Q000009:adverse effects; D019106:Postoperative Hemorrhage / Q000209:etiology / Q000601:surgery / Q000628:therapy*; D001749:Urinary Bladder Neoplasms / Q000150:complications / Q000601:surgery*; D014648:Varicose Veins / Q000150:complications / Q000188:drug therapy
chemical_list: D000269:Adhesives; D000925:Anticoagulants; D003487:Cyanoacrylates; D017762:Nadroparin; C421461:glubran 2