Molecular signatures define myogenic stem cell populations.
Developmental and regenerative mechanisms are directed by stem cell populations. Skeletal muscle is a dynamic tissue that is capable of adapting to stress and severe injury due to a resident somatic stem cell population. In response to a severe injury that destroys upward of 90% of the tissue, skeletal muscle efficiently and reproducibly regenerates damaged tissue and restores the cellular architecture within a 2-wk period. Recent studies have localized and examined the molecular regulation of skeletal muscle stem cell populations using emerging molecular biological technologies. These studies enhance the understanding of the regulatory mechanisms that direct the somatic stem cell populations and the role they play in development and regeneration. Furthermore, these basic science studies will serve as a platform for future therapies directed toward patients with myopathic diseases.
Martin
Cindy M
CM
Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX 75390, USA.
Russell
Jamie L
JL
Ferdous
Anwarul
A
Garry
Daniel J
DJ
D000818:Animals; D051858:Forkhead Transcription Factors / Q000502:physiology; D006801:Humans; D051379:Mice; D024510:Muscle Development / Q000502:physiology*; D018482:Muscle, Skeletal / Q000166:cytology / Q000502:physiology*; D013234:Stem Cells / Q000166:cytology / Q000502:physiology*
C495879:FOXK1 protein, human; D051858:Forkhead Transcription Factors