title: Chemical natures and application of 6-formylpterin derivatives.
abstract: Pterin, an analog of guanine, is an electron transfer compound in biological systems. Among the analogs, 6-formylpterin (6FP) has been demonstrated to have many marked physiological and pharmacological activities. In vitro, 6FP converts molecular oxygen to reactive oxygen species (ROS) in the presence of NADH or NADPH under light illumination, with the oxidation of NADH is to NAD(+). In the present study, it has been elucidated that some of 6FP derivatives in which the 3-position of 6FP is modified have such unique activities even in the dark where the most of in vivo biological events occur.
authors.affiliation: Institute of advanced Energy, Kyoto University, Uji 611-0011, Japan.
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Nonogawa
authors.forename: Sommani
authors.initials: S
authors.lastname: Piyanart
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Arai
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Endo
authors.forename: Seung Pil
authors.initials: SP
authors.lastname: Pack
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Kodaki
authors.forename: Keisuke
authors.initials: K
authors.lastname: Makino
mesh_terms: D003624:Darkness; D009243:NAD / Q000737:chemistry*; D010084:Oxidation-Reduction; D011622:Pterins / Q000737:chemistry*
chemical_list: D011622:Pterins; D009243:NAD; C005926:2-amino-4-hydroxy-6-formylpteridine