title: Chemical and biological consequences of locking the conformation of nucleosides at the two antipodal extremes of the pseudorotational cycle.
abstract: It is shown that in spite of the low energy barrier for the North (N)/South (S) equilibrium in nucleosides, enzymes show measurable differences in binding and/or catalytic activity between the two antipodal conformations.
authors.affiliation: Laboratory of Medicinal Chemistry, Center for Cancer Research, National Cancer Institute-Frederick, National Institutes of Health, Frederick, MD 21702, USA.
authors.forename: Victor E
authors.initials: VE
authors.lastname: Marquez
mesh_terms: D000818:Animals; D002522:Chlorocebus aethiops; D004798:Enzymes / Q000378:metabolism; D018259:Herpesvirus 1, Human / Q000502:physiology; D009690:Nucleic Acid Conformation; D009705:Nucleosides / Q000737:chemistry* / Q000378:metabolism*; D018047:Receptors, Purinergic P1 / Q000378:metabolism; D013329:Structure-Activity Relationship; D014709:Vero Cells
chemical_list: D004798:Enzymes; D009705:Nucleosides; D018047:Receptors, Purinergic P1