Intravascular cell-to-cell adhesive interactions and bone metastasis.
Metastatic cancer spread to bones, causing intractable pain, pathological fractures, spinal cord compression, and ultimately death, represents massive clinical problem. Intravascular cell-to-cell heterotypic (between cancer and other types of cells) and homotypic (between cancer cells) adhesive interactions, leading to the establishment of metastatic deposits in bone marrow vasculature, represent important rate-limiting steps in bone metastasis. In this review, we discuss molecular and cellular mechanisms underpinning metastasis-associated intravascular cell-to-cell adhesive interactions, their role in a multi-step metastatic cascade, and a potential for therapeutic targeting of early metastasis-associated adhesive events.
Glinsky
Vladislav V
VV
Harry S. Truman Memorial Veterans' Hospital, Columbia, MO 65201, USA. glinskiivl@missouri.edu
D000818:Animals; D001792:Blood Platelets / Q000166:cytology; D001854:Bone Marrow Cells / Q000473:pathology; D001859:Bone Neoplasms / Q000098:blood supply / Q000378:metabolism / Q000473:pathology* / Q000556:secondary*; D002448:Cell Adhesion; D015815:Cell Adhesion Molecules / Q000378:metabolism; D004727:Endothelium / Q000473:pathology; D006801:Humans
D015815:Cell Adhesion Molecules