title: Relation between plasma oxLDL antibodies and oxLDL in the circulation.
abstract: OBJECTIVE
  To investigate the possible relationship between circulating oxLDL and oxLDL Ab concentrations in order to better understand the role of oxLDL Ab in atherosclerosis.
  
  
  METHODS
  In a cross-sectional study of 86 patients undergoing ultrasonographic scanning of the carotid artery, concentration of circulating oxLDL and oxLDL Ab were determined by ELISA. For multivariate analysis, we also measured many conventional cardiovascular risk factors. Spearman's rank correlation test and chi-square test were used to evaluate the correlation between circulating oxLDL and oxLDL Ab. A stepwise multiple regression analysis and Logistic regression analysis were used to study the influencing factors.
  
  
  RESULTS
  There was no linear correlation between circulating oxLDL and oxLDL Ab. Circulating oxLDL was influenced by HDL, systolic blood pressure and body mass index, while only TC was independent factor associating with oxLDL Ab.
  
  
  CONCLUSIONS
  The present study showed that oxLDL was present at a low concentration in the circulation, and that plasma oxLDL had no linear correlation with oxLDL antibodies. However, the issue still needs further study.
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Shandong University, no.44 Wen Hua Xi Road, Jinan, Shandong 250012, People's Republic of China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.forename: Xueqiang
authors.initials: X
authors.lastname: Fang
authors.forename: Shumei
authors.initials: S
authors.lastname: Wang
authors.forename: Yueqiu
authors.initials: Y
authors.lastname: Feng
authors.forename: Jinghai
authors.initials: J
authors.lastname: Yin
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D050197:Atherosclerosis / Q000097:blood* / Q000000981:diagnostic imaging / Q000276:immunology / Q000503:physiopathology; D001323:Autoantibodies / Q000097:blood*; D001794:Blood Pressure; D015992:Body Mass Index; D002339:Carotid Arteries / Q000000981:diagnostic imaging; D002784:Cholesterol / Q000097:blood; D003430:Cross-Sectional Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008075:Lipoproteins, HDL / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood* / Q000276:immunology; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D012737:Sex Factors; D014463:Ultrasonography
chemical_list: D001323:Autoantibodies; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; C099252:oxidized low density lipoprotein; D002784:Cholesterol