title: Surfaces of fluorinated pyridinium block copolymers with enhanced antibacterial activity.
abstract: Polystyrene-b-poly(4-vinylpyridine) copolymers were quaternized with 1-bromohexane and 6-perfluorooctyl-1-bromohexane. Surfaces prepared from these polymers were characterized by contact angle measurements, near-edge X-ray absorption fine structure spectroscopy and X-ray photoelectron spectroscopy. The fluorinated pyridinium surfaces showed enhanced antibacterial activity compared to their nonfluorinated counterparts. Even a polymer with a relatively low molecular weight pyridinium block showed high antimicrobial activity. The bactericidal effect was found to be related to the molecular composition and organization in the top 2-3 nm of the surface and increased with increasing hydrophilicity and pyridinium concentration of the surface.
authors.affiliation: Department of Materials Science and Engineering, Cornell University, Ithaca, NY 14853, USA.
authors.forename: Sitaraman
authors.initials: S
authors.lastname: Krishnan
authors.forename: Rebekah J
authors.initials: RJ
authors.lastname: Ward
authors.forename: Alexander
authors.initials: A
authors.lastname: Hexemer
authors.forename: Karen E
authors.initials: KE
authors.lastname: Sohn
authors.forename: Kristen L
authors.initials: KL
authors.lastname: Lee
authors.forename: Esther R
authors.initials: ER
authors.lastname: Angert
authors.forename: Daniel A
authors.initials: DA
authors.lastname: Fischer
authors.forename: Edward J
authors.initials: EJ
authors.lastname: Kramer
authors.forename: Christopher K
authors.initials: CK
authors.lastname: Ober
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry*; D004926:Escherichia coli / Q000254:growth & development*; D005466:Fluorocarbons / Q000737:chemistry*; D006846:Hydrocarbons, Halogenated / Q000737:chemistry*; D011137:Polystyrenes / Q000737:chemistry*; D011145:Polyvinyls / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry*; D013052:Spectrometry, X-Ray Emission / Q000379:methods; D013211:Staphylococcus aureus; D013499:Surface Properties
chemical_list: D000900:Anti-Bacterial Agents; D005466:Fluorocarbons; D006846:Hydrocarbons, Halogenated; D011137:Polystyrenes; D011145:Polyvinyls; D011725:Pyridines; C509607:polystyrene-block-poly(4-vinylpyridine); C118701:1-bromohexane