Current concepts in adult stem cell therapy for stroke.
Acute ischemic stroke causes a disturbance of neuronal circuitry and disruption of the blood-brain-barrier that can lead to functional disabilities. At present, thrombolytic therapy inducing recanalization of the occluded vessels in the cerebral infarcted area is a commonly used therapeutic strategy. However, only a minority of patients have timely access to this kind of therapy. Therefore, finding other techniques to effectively treat stroke patients is an important research goal. Stem cell therapies, such as adult stem cell transplantation, are promising strategies for the treatment of stroke. Preclinical experimental studies have included the application of human stem cells from various sources including the brain, bone marrow, umbilical cord, and adipose tissue. This review provides an update on current preclinical cell-therapies for stroke, focusing on stem cells derived from adult sources.
Ding
Dah-Ching
DC
Graduate Institute of Medical Science, School of Medicine, Tzu Chi University, and Neuro-Medical Scientific Center, Buddhist Tzu-Chi General Hospital, Hualien, Taiwan.
Shyu
Woei-Cherng
WC
Lin
Shinn-Zong
SZ
Li
Hung
H
D000328:Adult; D053687:Adult Stem Cells / Q000166:cytology; D000368:Aged; D002545:Brain Ischemia / Q000628:therapy; D006801:Humans; D008875:Middle Aged; D033581:Stem Cell Transplantation / Q000379:methods*; D013234:Stem Cells / Q000166:cytology; D020521:Stroke / Q000628:therapy*