title: Analysis of DNA damage generated by high-energy particles.
abstract: Ionizing radiation generates isolated and localized multiple (i.e., clustered) lesions in DNA, and the latter is believed to be primarily responsible for deleterious biological consequences such as cell killing and mutations. In the present study, we irradiated plasmid and lambda DNA by ionizing radiations with different linear energy transfer (LET) values, and compared the yields of isolated and clustered DNA lesions.
authors.affiliation: Department of Mathematical and Life Sciences, Graduate School of Science, Hiroshima University, Higashi-Hiroshima 739-8526, Japan.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Terato
authors.forename: Ruri
authors.initials: R
authors.lastname: Tanaka
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Nakaarai
authors.forename: Yoshiya
authors.initials: Y
authors.lastname: Furusawa
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ide
mesh_terms: D002244:Carbon; D004249:DNA Damage; D005720:Gamma Rays; D007501:Iron; D018499:Linear Energy Transfer; D010957:Plasmids / Q000528:radiation effects; D011839:Radiation, Ionizing
chemical_list: D002244:Carbon; D007501:Iron