The long term effects of chemotherapy on the central nervous system.
Cranial radiotherapy is known to have adverse effects on intelligence. A new study shows that chemotherapy is also toxic to the central nervous system, especially to neural progenitor cells and oligodendrocytes. By identifying the cell populations at risk, these results may help explain the neurological problems previously seen after chemotherapy.
Duffner
Patricia K
PK
Department of Neurology, Women and Children's Hospital of Buffalo, University of Buffalo School of Medicine, 219 Bryant St, Buffalo, NY 14222, USA. PatriciaDuffner@aol.com
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D001932:Brain Neoplasms / Q000188:drug therapy / Q000532:radiotherapy; D002490:Central Nervous System / Q000187:drug effects* / Q000473:pathology; D016543:Central Nervous System Neoplasms / Q000188:drug therapy / Q000532:radiotherapy; D003072:Cognition Disorders / Q000139:chemically induced / Q000517:prevention & control; D006801:Humans; D013995:Time
D000970:Antineoplastic Agents