Role of hormone cofactors in the human papillomavirus-induced carcinogenesis of the uterine cervix.
If human papillomavirus (HPV) is necessary for the development of (pre)neoplastic lesions of the uterine cervix, it is not sufficient. Among the cofactors involved in the malignant transformation of cells infected by HPV, sex hormones may facilitate the cervical carcinogenesis by different mechanisms, including the induction of squamous metaplasia in the transformation zone of the cervix, interactions between steroid hormones and HPV gene expression and alterations of the local immune microenvironment.
Delvenne
Philippe
P
Department of Pathology, CRCE-CBIG, B35, University of Liege, CHU Sart Tilman, 4000 Liege, Belgium. P.Delvenne@ulg.ac.be
Herman
Ludivine
L
Kholod
Natalia
N
Caberg
Jean-Hubert
JH
Herfs
Michaël
M
Boniver
Jacques
J
Jacobs
Nathalie
N
Hubert
Pascale
P
D002294:Carcinoma, Squamous Cell / Q000276:immunology / Q000378:metabolism* / Q000473:pathology / Q000821:virology; D002472:Cell Transformation, Viral / Q000276:immunology; D002584:Cervix Uteri / Q000276:immunology / Q000378:metabolism / Q000473:pathology / Q000821:virology; D005260:Female; D015967:Gene Expression Regulation, Viral; D012739:Gonadal Steroid Hormones / Q000378:metabolism*; D006801:Humans; D008679:Metaplasia; D014412:Tumor Virus Infections / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D002583:Uterine Cervical Neoplasms / Q000276:immunology / Q000378:metabolism* / Q000473:pathology / Q000821:virology
D012739:Gonadal Steroid Hormones