title: Design, synthesis and evaluation of oligomer conjugated MGBpolyamide-nucleoside hybrid as a novel gene expression control compound.
abstract: DNA oligomers conjugated pyrrolepolyamide (minor groove binder)-deoxyguanosine hybrid were synthesized as novel gene expression control compounds. From T(m) values and CD spectral analysis, it was found that oligomers conjugated hybrid possess high recognition ability and very high binding ability for the DNA that includes pyrrolepolyamide match site.
authors.affiliation: School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.
authors.forename: Etsuko
authors.initials: E
authors.lastname: Kawashima
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Ohba
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Terui
authors.forename: Kazuo
authors.initials: K
authors.lastname: Kamaike
mesh_terms: D002942:Circular Dichroism; D004247:DNA / Q000737:chemistry; D003849:Deoxyguanosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D005786:Gene Expression Regulation; D015316:Genetic Therapy; D020319:Oligodeoxyribonucleotides, Antisense / Q000737:chemistry*; D011758:Pyrroles / Q000138:chemical synthesis / Q000737:chemistry*; D013696:Temperature
chemical_list: C520215:2'-deoxy-N(2)-(3-(4-(4-(4-formamido-1-methylpyrrole-2-carboxamido)-1-methylpyrrole-2-carboxamido)-1-methylpyrrole-2-carboxamido)propyl)guanosine; D020319:Oligodeoxyribonucleotides, Antisense; D011758:Pyrroles; D004247:DNA; D003849:Deoxyguanosine