Synthesis and base recognition ability of oligoribonucleotides incorporating 2'-O-methyl-3-deazaguanosine.
2'-O-methyl-oligoribonucleotides incorporating a 3-deazaguanine (3DG) were synthesized. Melting temperature (Tm value) analysis indicates the stability and base discriminating ability of the 2'-O-methyl-RNA/RNA duplex.
Seio
Kohji
K
Frontier Collaborative Research Center, Tokyo Institute of Technology, Nagatsuda, Midoriku, Yokohama 226-8503, Japan.
Sasami
Takeshi
T
Sekine
Mitsuo
M
D020137:Base Pair Mismatch; D020029:Base Pairing; D006151:Guanosine / Q000031:analogs & derivatives* / Q000737:chemistry; D009843:Oligoribonucleotides / Q000138:chemical synthesis* / Q000737:chemistry*
C521144:2'-O-methyl-3-deazaguanosine; D009843:Oligoribonucleotides; D006151:Guanosine; C010568:3-deazaguanosine