title: New insights into the assessment of the prosthetic valve performance in the presence of subaortic stenosis through a fluid-structure interaction model.
abstract: The aim of this study was to contribute to improving the accuracy of clinical assessments of valve performance in situations involving the concomitant presence of a prosthetic valve and subaortic stenosis (SAS). Physiological flow in a two-dimensional model for a bileaflet mechanical heart valve was investigated numerically in terms of the fluid-structure interactions. The fluid dynamics in a model with SAS of the left ventricle outflow tract were compared with those given by a healthy model. The results show that in the model with SAS, one leaflet did not close during the observed systolic phase, whereas the other one showed similar behaviour to that of the leaflet in the healthy model. In addition, the main flow did not occur along the central axis and a deviated jet was set up between leaflets, contrary to what occurred in the model without SAS. Current clinical diagnostic indices, which are mainly based on the central jet flow velocities, are therefore unsuitable for use in this pathological situation and should be used with great caution.
authors.affiliation: IRPHE UMR 6594, Equipe de Biomécanique Cardiovasculaire, Marseille, France. carine.guivier@irphe.univ-mrs.fr
authors.forename: Carine
authors.initials: C
authors.lastname: Guivier
authors.forename: Valerie
authors.initials: V
authors.lastname: Deplano
authors.forename: Philippe
authors.initials: P
authors.lastname: Pibarot
mesh_terms: D001024:Aortic Valve Stenosis / Q000503:physiopathology*; D001783:Blood Flow Velocity; D003198:Computer Simulation; D006350:Heart Valve Prosthesis; D006352:Heart Ventricles / Q000503:physiopathology; D006801:Humans; D008955:Models, Cardiovascular; D013314:Stress, Mechanical