title: Antipyretic effect of Mao-to, a Japanese herbal medicine, for treatment of type A influenza infection in children.
abstract: Mao-to is a Japanese traditional herbal medicine which has been used since ancient times for the treatment of influenza-like illness. This study was conducted to evaluate the effect of oral Mao-to administration in children with type A influenza, in comparison to Oseltamivir. We performed a controlled trial of 60 children, from 5 months through 13 years of age, with fever and influenza-like symptom of up to 48 h duration. Diagnosis of influenza type A was performed by virus isolation or detection of a viral gene by RT-PCR. Patients assigned into the following 3 groups: oral Mao-to powder (TJ-27) 0.06 g/kg body wt./dose three times daily (n=17), Oseltamivir 2 mg/kg body wt./dose twice daily (n=18) or both oral Mao-to plus Oseltamivir (n=14). The median duration of fever after treatment was significantly shorter in the Mao-to and Mao-to plus Oseltamivir groups, compared with the Oseltamivir only group (15 h [95%CI 13.2-22.1] p<0.01; 18 h[15.2-27.7] p<0.05; 24 h[23.5-43.0], respectively). Oral Mao-to administration was effective in the control of fever due to type A influenza infection in children.
authors.affiliation: Department of Pediatrics, Self Defense Force Sendai Hospital, Minaminometate 1-1, Miyaginoku, Sendai, Miyagi, Japan. bokukubo17@hotmail.com
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Kubo
authors.forename: Hidekazu
authors.initials: H
authors.lastname: Nishimura
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage / Q000627:therapeutic use*; D000998:Antiviral Agents / Q000008:administration & dosage / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D017931:DNA Primers; D004279:DNA, Viral / Q000032:analysis; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D005334:Fever / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D007223:Infant; D009980:Influenza A virus / Q000235:genetics / Q000302:isolation & purification; D007251:Influenza, Human / Q000150:complications / Q000188:drug therapy; D007564:Japan; D008297:Male; D008516:Medicine, Chinese Traditional; D053139:Oseltamivir / Q000008:administration & dosage / Q000627:therapeutic use; D008517:Phytotherapy; D020133:Reverse Transcriptase Polymerase Chain Reaction; D016896:Treatment Outcome
chemical_list: D018712:Analgesics, Non-Narcotic; D000998:Antiviral Agents; D017931:DNA Primers; D004279:DNA, Viral; D004365:Drugs, Chinese Herbal; C493483:Mao-to; D053139:Oseltamivir