Scavenging effect and antispasmodic activity of the essential oil of Cyclotrichium niveum.
The radical scavenging and the spasmolitic activity of Cyclotrichium niveum essential oil were evaluated in vitro. It showed an IC(50) of 1750 microg/ml on DPPH method and dose dependently (0.1, 0.5 and 1 mg/ml) inhibits the contraction induced by carbachol on rabbit bladder from 15 to 100%. Moreover, it was able to inhibit the rat ileum muscle by 30 to 100%.
Cetinus
Senay Akkuş
SA
Department of Chemistry, Faculty of Science and Literature, Cumhuriyet University, 58140 Turkey. scetinus@cumhuriyet.edu.tr
Göze
Ismihan
I
Saraç
Bülent
B
Vural
Nilüfer
N
D000818:Animals; D001713:Biphenyl Compounds; D002217:Carbachol; D004305:Dose-Response Relationship, Drug; D005260:Female; D016166:Free Radical Scavengers / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D010276:Parasympatholytics / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D008517:Phytotherapy; D010851:Picrates / Q000737:chemistry; D035261:Plant Components, Aerial; D010938:Plant Oils / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D010946:Plants, Medicinal; D011817:Rabbits; D051381:Rats; D017208:Rats, Wistar; D001743:Urinary Bladder / Q000187:drug effects
D001713:Biphenyl Compounds; D016166:Free Radical Scavengers; D010276:Parasympatholytics; D010851:Picrates; D010938:Plant Oils; D002217:Carbachol; C004931:1,1-diphenyl-2-picrylhydrazyl