[Therapeutic effects of early administration of low-dose heparin in patients with severe sepsis].
OBJECTIVE
To study the therapeutic effects of early administration of low-dose heparin in patients with severe sepsis.


METHODS
Twenty-two patients were randomly divided into experimental group and control group. In addition to the routine treatment, the patients in experimental group were given low-dose heparin, while those in control group were not. Prothrombin time (PT), activated partial thromboplastin time (APTT), platelet count, APACHE II score, ICU days, hospital days, cure rate, and 28-day survival rate were investigated in the two groups.


RESULTS
After the treatment, PT and APTT recovered normal in the experimental group, but remained abnormal in the control group. There was no significant difference in platelet count between the two groups. ICU days in experimental group was shorter than that in control group (P < 0.01). Cure rate in experimental group was 81.8%, which was significantly higher than that in control group (54.5%). There was no significant difference in hospital days and 28-day survival rate between the two groups.


CONCLUSIONS
Early administration of low-dose heparin therapy can improve coagulative function in patients with severe sepsis, however, the survival rate was not improved.
Zhang
Xiao-juan
XJ
Department of Intensive Care Unit, the First Affiliated Hospital of China Medical University, Shenyang 110001, China. xiaojuan0926@tom.com
Ma
Xiao-chun
XC
D000368:Aged; D000925:Anticoagulants / Q000008:administration & dosage*; D003131:Combined Modality Therapy; D005260:Female; D006493:Heparin / Q000008:administration & dosage*; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D018805:Sepsis / Q000188:drug therapy / Q000401:mortality / Q000628:therapy*; D015996:Survival Rate; D016896:Treatment Outcome
D000925:Anticoagulants; D006493:Heparin