title: Synthesis and biological evaluation of some 6-substituted purines.
abstract: We report herein the synthesis and the in vitro antileishmanial evaluation of a series of 6-substituted purines. The most active compounds against Leishmania amazonensis promastigotes were 6-(3'-chloropropylthio)purine 2 [11,12] [corrected] 6-(3'-(thioethylamine)propylthio)purine 5, 6-(alpha-aceticacidthio)purine 7 and 6-(6'-deoxy-1'-O-methyl-beta-D-ribofuranose)purine 14 with an IC(50)=50, 50, 39 and 29 microM, respectively.
authors.affiliation: Departamento de Parasitologia, Microbiologia e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Juiz de Fora, Campus Universitario, Bairro Martelos, Juiz de Fora, Minas Gerais 36036-900, Brazil.
authors.forename: Fernanda Gambogi
authors.initials: FG
authors.lastname: Braga
authors.forename: Elaine Soares
authors.initials: ES
authors.lastname: Coimbra
authors.forename: Magnum
authors.initials: M
authors.lastname: de Oliveira Matos
authors.forename: Arturene Maria
authors.initials: AM
authors.lastname: Lino Carmo
authors.forename: Marisa Damato
authors.initials: MD
authors.lastname: Cancio
authors.forename: Adilson David
authors.initials: AD
authors.lastname: da Silva
mesh_terms: D000818:Animals; D005021:Ethylamines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D007891:Leishmania / Q000187:drug effects*; D008264:Macrophages / Q000187:drug effects; D051379:Mice; D015394:Molecular Structure; D021261:Parasitic Sensitivity Tests; D011687:Purines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: C527447:6-(3'-(thioethylamine)propylthio)purine; C527444:6-(3'-chloropropylthio)purine; C527446:6-(6'-deoxy-1'-O-methyl-beta-D-ribofuranose)purine; D005021:Ethylamines; D011687:Purines