Coexistence of nodular regenerative hyperplasia of the liver and pulmonary arterial hypertension in patients with connective tissue diseases: report of three cases and review of the literature.
Nodular regenerative hyperplasia of the liver (NRH) is known to be a rare condition in patients with connective tissue diseases (CTD). In this report, we document three patients with CTD who had both NRH and pulmonary hypertension (PH). All three patients developed PH during their course and thereafter developed NRH. The clinical course of these patients suggests that circulatory disturbance caused by PH might be a trigger for NRH.
Watabe
Hiroyuki
H
Department of Rheumatology and Infectious Diseases, Kitasato University School of Medicine, 1-15-1 Kitasato, Sagamihara, Kanagawa 228-8555, Japan. dm02036d@st.kitasato-u.ac.jp
Akahoshi
Tohru
T
Okada
Jun
J
Kokubu
Shigehiro
S
Kurihara
Yuko
Y
Kondo
Hirobumi
H
D000293:Adolescent; D000368:Aged; D003240:Connective Tissue Diseases / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D017809:Fatal Outcome; D005260:Female; D020518:Focal Nodular Hyperplasia / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D022781:Hepatocytes / Q000473:pathology; D006801:Humans; D006976:Hypertension, Pulmonary / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D011651:Pulmonary Artery / Q000473:pathology* / Q000503:physiopathology; D013902:Radiography, Thoracic