Models of abdominal aortic aneurysm: characterization and clinical applications.
Abdominal aortic aneurysms (AAAs) are responsible for considerable morbidity, mortality, and cost to society. The pathogenesis of AAA formation, however, remains poorly understood. Animal models have been used in a range of experiments designed to provide further objective scientific assessment of the pathogenesis as well as the treatment of AAA. The purpose of this manuscript is to review the current models of AAA and their potential clinical implications.
Chaer
Rabih A
RA
Division of Vascular Surgery, New York Presbyterian Hospital, Cornell University, Weill Medical School, NY 10021, USA.
DeRubertis
Brian G
BG
Hynecek
Robert
R
Kent
K Craig
KC
Faries
Peter L
PL
D000818:Animals; D017544:Aortic Aneurysm, Abdominal / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D001807:Blood Vessel Prosthesis; D019917:Blood Vessel Prosthesis Implantation / Q000295:instrumentation*; D004195:Disease Models, Animal; D004285:Dogs; D006801:Humans; D018810:Magnetic Resonance Angiography; D019028:Magnetic Resonance Imaging, Cine; D051379:Mice; D011312:Pressure; D011474:Prosthesis Design; D011475:Prosthesis Failure; D015607:Stents; D014654:Vascular Patency