[Expression of key regulatory apoptotic proteins and their role in thymic involution in human aging].
Immunohistochemical verification of the expression of pro-apoptotic protein p53 and anti-apoptotic protein mcl-1 in non-lymphoid structures of human thymus of different age groups has been carried out. It has been shown, that thymic involution starts very early in postnatal ontogenesis, which is testified by the decrease of mcl-1 expression during first months of child life, and at the same time the expression of pro-apoptotic protein p53 noticeably increases during the first year. It was established that deceleration of thymic involution is connected with the decrease of p53 expression, but not with the increase of mcl-1 expression during aging.
Poliakova
V O
VO
Benberin
V V
VV
D000375:Aging / Q000502:physiology*; D017209:Apoptosis / Q000502:physiology*; D006801:Humans; D064549:Myeloid Cell Leukemia Sequence 1 Protein; D009363:Neoplasm Proteins / Q000096:biosynthesis*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000096:biosynthesis*; D013950:Thymus Gland / Q000378:metabolism / Q000502:physiology*; D016159:Tumor Suppressor Protein p53 / Q000096:biosynthesis*
D064549:Myeloid Cell Leukemia Sequence 1 Protein; D009363:Neoplasm Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D016159:Tumor Suppressor Protein p53