title: Synthesis and biological activity of 4'',6''-unsaturated cyclic ADP-carbocyclic-ribose.
abstract: 4'',6''-Unsaturated cyclic ADP-carbocyclic-ribose (3) was designed as a novel stale mimic of cyclic ADP-ribose, an intracellular Ca2+-mobilizing second messenger, based on the previous SAR studies, and was successfully synthesized.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo 060-0812, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Kudoh
authors.forename: Takashi
authors.initials: T
authors.lastname: Murayama
authors.forename: Akira
authors.initials: A
authors.lastname: Matsuda
authors.forename: Satoshi
authors.initials: S
authors.lastname: Shuto
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002478:Cells, Cultured; D036563:Cyclic ADP-Ribose / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D051379:Mice
chemical_list: C439996:cyclic ADP-carbocyclic-ribose; D036563:Cyclic ADP-Ribose; D002118:Calcium