title: Adaptive allocation and failure saving in randomised clinical trials.
abstract: In the present work, we develop a randomized two-treatment single period response adaptive design by combining two contrasting aspects (i.e., ethics and optimality), where optimality is defined in a meaningful way. We compare this rule with some of the existing rules by computing various performance measures of the rules.
authors.affiliation: Department of Statistics, University of Calcutta, Kolkata, India. bandyopadhyay@yahoo.com
authors.forename: Uttam
authors.initials: U
authors.lastname: Bandyopadhyay
authors.forename: Rahul
authors.initials: R
authors.lastname: Bhattacharya
mesh_terms: D000465:Algorithms; D003866:Depressive Disorder / Q000188:drug therapy / Q000523:psychology; D005473:Fluoxetine / Q000627:therapeutic use; D006801:Humans; D011569:Psychiatric Status Rating Scales; D016032:Randomized Controlled Trials as Topic / Q000941:ethics / Q000706:statistics & numerical data*; D012107:Research Design / Q000706:statistics & numerical data; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D005473:Fluoxetine; D017367:Selective Serotonin Reuptake Inhibitors