Evaluation of anxiolytic potential of Celastrus oil in rat models of behaviour.
The Celastrus oil, extracted from seeds of Celastrus paniculatus tested at 2 dose levels (1 and 1.5 g/kg), exhibited significant anxiolytic activity and did not produce tolerance. The non-sedative nature and reversal of buspirone induced behaviour (in open field exploration) point to the serotonergic mechanism underlying the anxiolysis, inspiring further research.
Rajkumar
Ramamoorthy
R
J.S.S. College of Pharmacy, Ooty, India. rajkumarrna@yahoo.com
Kumar
Elavarasan Prem
EP
Sudha
Suresh
S
Suresh
Bhojraj
B
D000818:Animals; D014151:Anti-Anxiety Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D001008:Anxiety Disorders / Q000188:drug therapy; D001522:Behavior, Animal / Q000187:drug effects*; D029753:Celastraceae; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D023421:Models, Animal; D008517:Phytotherapy; D010938:Plant Oils / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D012639:Seeds
D014151:Anti-Anxiety Agents; D010938:Plant Oils; C097139:Celastrus oil