Auraptene decreases the activity of matrix metalloproteinases in dextran sulfate sodium-induced ulcerative colitis in ICR mice.
Previously we reported that auraptene was a potent suppressant for matrix metalloproteinase (MMP)-7 expression in HT-29 human colon cancer cells. In the present study, we examined the effects of auraptene on MMP-2, -7, and -9 expression in colonic mucosa from dextran sulfate sodium (DSS)-induced ulcerative colitis mice. Auraptene remarkably suppressed the DSS-induced gelatinolytic activity of MMP-7 as well as the expression of MMP-2 and -9, suggesting that it might be useful in anti-metastatic therapies via the targeting of MMPs.
Kawabata
Kyuichi
K
Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University.
Murakami
Akira
A
Ohigashi
Hajime
H
D000818:Animals; D003093:Colitis, Ulcerative / Q000139:chemically induced* / Q000201:enzymology; D003374:Coumarins / Q000494:pharmacology*; D016264:Dextran Sulfate / Q000633:toxicity*; D005260:Female; D061965:Matrix Metalloproteinase Inhibitors; D051379:Mice; D008813:Mice, Inbred ICR
D003374:Coumarins; D061965:Matrix Metalloproteinase Inhibitors; D016264:Dextran Sulfate; C105832:aurapten