Evaluation of GC-ion trap-MS/MS methodology for monitoring PCDD/Fs in infant formulas.
The application of high resolution gas chromatography in combination with low resolution mass spectrometry with electron ionization and MS/MS detection (HRGC-MS/MS) is tested for its use in the analysis of PCDD/Fs in infant formulas. Development of the analytical method was based upon EPA directrices and international recommendations. Calibration linearity was tested and average relative response for any native and labelled compound over the five-point calibration range below 14% was found. The precision and accuracy of the proposed analytical procedure are also presented. Results obtained are in agreement with EPA criteria. The method is applied to the analysis of a number of initial and follow-on milk based infant formulas. In general, HRGC-MS/MS constitutes an interesting method for the analysis of dioxins in such matrices.
Lorán
Susana
S
University of Zaragoza, Department of Animal Production and Food Science, Veterinary Faculty, C/Miguel Servet 177, 50013 Zaragoza, Spain.
Bayarri
Susana
S
Conchello
Pilar
P
Herrera
Antonio
A
D001572:Benzofurans / Q000032:analysis*; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods*; D041943:Infant Formula / Q000737:chemistry*; D000072317:Polychlorinated Dibenzodioxins / Q000031:analogs & derivatives* / Q000032:analysis; D015203:Reproducibility of Results; D053719:Tandem Mass Spectrometry / Q000379:methods*
D001572:Benzofurans; D000072317:Polychlorinated Dibenzodioxins; C023614:dibenzofuran