title: Macroporous hydrogels based on 2-hydroxyethyl methacrylate. Part 5: hydrolytically degradable materials.
abstract: Macroporous hydrogels based on 2-hydroxyethyl methacrylate, 2-ethoxyethyl methacrylate and N-(2-hydroxypropyl)methacrylamide, methacrylic acid and [2-(methacryloyloxy)ethyl]trimethylammonium chloride crosslinked with N,O-dimethacryloylhydroxylamine were prepared. Hydrogels were degraded in a buffer of pH 7.4. Completely water-soluble polymers were obtained over time periods ranging from 2 to 40 days. The process of degradation was followed gravimetrically and by optical and electron microscopy. In vivo biological tests with hydrogels based on copolymers of 2-ethoxyethyl methacrylate/N-(2-hydroxypropyl)methacrylamide were performed.
authors.affiliation: Academy of Sciences of the Czech Republic, Institute of Macromolecular Chemistry, 16206, Prague 6, Czech Republic. pradny@imc.cas.cz
authors.forename: Martin
authors.initials: M
authors.lastname: Prádný
authors.forename: Jirí
authors.initials: J
authors.lastname: Michálek
authors.forename: Petr
authors.initials: P
authors.lastname: Lesný
authors.forename: Ales
authors.initials: A
authors.lastname: Hejcl
authors.forename: Jirí
authors.initials: J
authors.lastname: Vacík
authors.forename: Miroslav
authors.initials: M
authors.lastname: Slouf
authors.forename: Eva
authors.initials: E
authors.lastname: Syková
mesh_terms: D020341:Absorbable Implants; D000818:Animals; D001672:Biocompatible Materials / Q000378:metabolism* / Q000627:therapeutic use; D005260:Female; D020100:Hydrogels / Q000378:metabolism* / Q000627:therapeutic use; D006868:Hydrolysis; D008422:Materials Testing / Q000379:methods; D008689:Methacrylates / Q000378:metabolism* / Q000627:therapeutic use; D016062:Porosity; D051381:Rats; D017208:Rats, Wistar; D013118:Spinal Cord Diseases / Q000473:pathology / Q000628:therapy
chemical_list: D001672:Biocompatible Materials; D020100:Hydrogels; D008689:Methacrylates; C005044:hydroxyethyl methacrylate