A genomewide linkage analysis of Kawasaki disease: evidence for linkage to chromosome 12.
Kawasaki disease (KD) is an acute systemic vasculitis syndrome that primarily affects infants and young children. The cause of KD is largely unknown, but its higher incidence in the Asian population and increased risk in patients' families suggests the existence of underlying genetic factors. To determine the loci of a susceptibility gene for KD, a genomewide linkage analysis with affected sib pairs was performed on 78 family samples collected from all over Japan. Multipoint linkage analysis using MAPMAKER/SIBS 2.0 identified evidence of linkage on 12q24 [maximum lod score (MLS) = 2.69]. Possible linkage (MLS > 1.0) was also found on 4q35, 5q34, 6q27, 7p15, 8q24, 18q23, 19q13, Xp22, and Xq27. This is the first large-scale study of the genetic susceptibility to KD, and our results, combined with the accumulated knowledge of the human genome, could greatly promote research on identification of the molecular pathogenesis of KD.
Onouchi
Yoshihiro
Y
Laboratory for Gastrointestinal Diseases, SNP Research Center, RIKEN, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa, 230-0045, Japan. onouchi@src.riken.jp.
Tamari
Mayumi
M
Laboratory for Genetics of Allergic Diseases, SNP Research Center, RIKEN, Yokohama, Japan.
Takahashi
Atsushi
A
Laboratory for Statistical Analysis, SNP Research Center, RIKEN, Tokyo, Japan.
Tsunoda
Tatsuhiko
T
Laboratory for Medical Informatics, SNP Research Center, RIKEN, Yokohama, Japan.
Yashiro
Mayumi
M
Department of Public Health, Jichi Medical School, Minamikawachi, Tochigi, Japan.
Nakamura
Yoshikazu
Y
Department of Public Health, Jichi Medical School, Minamikawachi, Tochigi, Japan.
Yanagawa
Hiroshi
H
Saitama Prefectural University, Koshigaya, Saitama, Japan.
Wakui
Keiko
K
Department of Preventive Medicine, Shinshu University School of Medicine, Matsumoto, Japan.
Fukushima
Yoshimitsu
Y
Department of Preventive Medicine, Shinshu University School of Medicine, Matsumoto, Japan.
Kawasaki
Tomisaku
T
Japan Kawasaki Disease Research Center, Tokyo, Japan.
Nakamura
Yusuke
Y
Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Hata
Akira
A
Laboratory for Gastrointestinal Diseases, SNP Research Center, RIKEN, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa, 230-0045, Japan.|Department of Public Health, Chiba University Graduate School of Medicine, Chiba, Japan.
D002874:Chromosome Mapping; D002881:Chromosomes, Human, Pair 12 / Q000235:genetics*; D005190:Family; D005260:Female; D008040:Genetic Linkage; D015894:Genome, Human; D005838:Genotype; D006801:Humans; D008297:Male; D009080:Mucocutaneous Lymph Node Syndrome / Q000235:genetics*