title: Development of physical and numerical techniques of Alanine/EPR dosimetry in radiotherapy.
abstract: In this work, a set of 50 alanine dosimeters has been used in a radiotherapy context, simulating a two-dimensional treatment in a non-overlapping dosimeter configuration. The dose is reconstructed from physical and numerical simulation of the electron paramagnetic resonance signal, calculating the spin density. Thus, it can be used to better adjust the error in the calibration curve to give a final accuracy of <0.03 Gy. A complete set of experimental test parameters have been used with a standard dosimeter in order to obtain the best analysis configuration. These results indicate that for a conventional treatment of some hundreds of mGy, this method can be useful with a correct signal validation. A numerical test and fitting software has been developed. The general use of alanine/electron paramagnetic resonance dosimetry in radiotherapy context is discussed.
authors.affiliation: Departamento de Física, Universidade de Aveiro, 3810-193 Aveiro, Portugal.
authors.forename: F
authors.initials: F
authors.lastname: Castro
authors.forename: F
authors.initials: F
authors.lastname: Ponte
authors.forename: L
authors.initials: L
authors.lastname: Pereira
mesh_terms: D000409:Alanine / Q000737:chemistry* / Q000528:radiation effects*; D003198:Computer Simulation; D017076:Computer-Aided Design; D004578:Electron Spin Resonance Spectroscopy / Q000295:instrumentation* / Q000379:methods; D004867:Equipment Design; D019544:Equipment Failure Analysis; D008956:Models, Chemical; D011874:Radiometry / Q000295:instrumentation* / Q000379:methods*; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000295:instrumentation* / Q000379:methods; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D000409:Alanine