Taurine attenuates pyridoxal-induced adrenomedullary catecholamine release and glycogenolysis in the rat.
The vitamin B6 vitamers, pyridoxine, pyridoxal and pyridoxamine are capable of promoting the mobilization of hepatic glycogen stores and hyperglycemia in the rat. These effects, which are dose-related and far greater with pyridoxal than with the other B6 vitamers, follow the outpouring of adrenomedullary catecholamines into the circulation. By taking advantage of this animal model, the present study was undertaken to examine the validity of a previously held view that taurine can suppress the release of adrenomedullary catecholamines. By treating Sprague-Dawley rats with intraperitoneal doses of pyridoxal, taurine, beta-alanine, specific pharmacological antagonists (atropine, hexamethonium, labetalol, propranolol, verapamil) and their combinations, it was determined that the attenuating action of taurine on pyridoxal-induced glycogenolysis is centered in the adrenal gland.
Patel
Jagir P
JP
St. John's University, College of Pharmacy and Allied Health Professions, Jamaica, NY 11439, USA.
Lau-Cam
Cesar A
CA
D000313:Adrenal Medulla / Q000378:metabolism*; D000315:Adrenalectomy; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002395:Catecholamines / Q000097:blood*; D006003:Glycogen / Q000378:metabolism*; D008297:Male; D011730:Pyridoxal / Q000378:metabolism*; D011733:Pyridoxamine / Q000378:metabolism; D011736:Pyridoxine / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D013153:Splanchnic Nerves / Q000601:surgery; D013562:Sympathectomy; D013654:Taurine / Q000378:metabolism*; D014803:Vitamin B Complex / Q000378:metabolism
D001786:Blood Glucose; D002395:Catecholamines; D014803:Vitamin B Complex; D013654:Taurine; D011730:Pyridoxal; D011733:Pyridoxamine; D006003:Glycogen; D011736:Pyridoxine