title: Analysis of HIV type 1 diversity in pregnant women from four Latin American and Caribbean countries.
abstract: Worldwide, the distribution of HIV-1 subtypes and intersubtype recombinants is not homogeneous. In Latin America and the Caribbean, HIV-1 subtype B predominates. However, in the south of Brazil and in countries of the Southern cone (Argentina, Chile, Paraguay, and Uruguay) there is a different distribution of viral subtypes and intersubtype recombinants. The aim of this work was to analyze HIV-1 diversity in a cohort of pregnant women (with primarily heterosexual acquisition of the infection) who were diagnosed with HIV-1 infection during their current pregnancy and who received ARVs during pregnancy for perinatal transmission prophylaxis. Analysis of 121 partial pol sequences from subjects enrolled in Argentina, Brazil, the Bahamas, and Mexico was performed by phylogenetic and recombinant characterization. Different prevalences of subtype B were observed (100% for specimens from Mexico and the Bahamas, 61% for Brazil, and 30% for Argentina). Subtypes C and F were found, along with BC, BF, FC, and CBF recombinants in specimens from Brazilians. A high prevalence of BF recombinants was found (70%) in specimens from Argentina. The different patterns of HIV- 1 subtypes and intersubtype recombinants in South America (Argentina and Brazil) compared to those in Central and North America should be considered in the design of future HIV-1 vaccine trials.
authors.affiliation: Centro Nacional de Referencia para el SIDA, School of Medicine, University of Buenos Aires, Buenos Aires, Argentina.
authors.forename: Manuel
authors.initials: M
authors.lastname: Gomez-Carrillo
authors.forename: Sandra
authors.initials: S
authors.lastname: Pampuro
authors.forename: Adriana
authors.initials: A
authors.lastname: Duran
authors.forename: Marcelo
authors.initials: M
authors.lastname: Losso
authors.forename: D Robert
authors.initials: DR
authors.lastname: Harris
authors.forename: Jennifer S
authors.initials: JS
authors.lastname: Read
authors.forename: Geraldo
authors.initials: G
authors.lastname: Duarte
authors.forename: Ricardo
authors.initials: R
authors.lastname: De Souza
authors.forename: Luis
authors.initials: L
authors.lastname: Soto-Ramirez
authors.forename: Horacio
authors.initials: H
authors.lastname: Salomón
mesh_terms: D001118:Argentina / Q000453:epidemiology; D001444:Bahamas / Q000453:epidemiology; D001938:Brazil / Q000453:epidemiology; D005260:Female; D015684:Gene Products, pol / Q000235:genetics; D014644:Genetic Variation; D015658:HIV Infections / Q000453:epidemiology* / Q000821:virology*; D015497:HIV-1 / Q000235:genetics* / Q000302:isolation & purification*; D006801:Humans; D008800:Mexico / Q000453:epidemiology; D010802:Phylogeny; D011247:Pregnancy
chemical_list: D015684:Gene Products, pol