Tissue-specific expression of Riken 2810430M08 and its function in T-cell immune responses.
Riken 2810430M08 is a gene with unknown functions. According to in situ hybridization (ISH), it presented a pattern of temporal expression, peaking in the mid-gestation (embryonic Days e9-e14) stage in most tissues. In the late-gestation stage and during the adulthood, Riken 2810430M08 was expressed in some tissues with and without a robust proliferation program. Thus, the gene might have important functions that are related and unrelated to proliferation. Its expression was induced after T-cell receptor stimulation in T cells. However, transgenic mice with actin promoter-driven expression of Riken 2810430M08 showed normal in vitro and in vivo T cells responses, such as fetal thymus development, adult T cells activation marker expression, lymphokine secretion, proliferation and migration, and delayed type hypersensitivity (DTH). The expression of Riken 2810430M08 during ontogeny has provided useful clues for further investigation. Additional studies are warranted to examine its role in immune and other systems.
Wu
Tao
T
Institute of Cardiology, the First Affiliated Hospital, Zhejiang University, Hangzhou, China.
Hu
Shenjiang
S
Qiao
Xiaoying
X
Luo
Hongyu
H
Wu
Jiangping
J
D000199:Actins / Q000378:metabolism; D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D002454:Cell Differentiation; D002465:Cell Movement; D049109:Cell Proliferation; D004622:Embryo, Mammalian; D005786:Gene Expression Regulation; D005796:Genes; D006968:Hypersensitivity, Delayed / Q000276:immunology; D017403:In Situ Hybridization; D008213:Lymphocyte Activation / Q000235:genetics / Q000502:physiology; D008222:Lymphokines / Q000378:metabolism; D051379:Mice; D008822:Mice, Transgenic; D020411:Oligonucleotide Array Sequence Analysis; D011401:Promoter Regions, Genetic; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D011948:Receptors, Antigen, T-Cell / Q000276:immunology*; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology*; D013950:Thymus Gland / Q000166:cytology / Q000196:embryology / Q000276:immunology*; D013997:Time Factors; D014018:Tissue Distribution
D000199:Actins; D015415:Biomarkers; D008222:Lymphokines; D012333:RNA, Messenger; D011948:Receptors, Antigen, T-Cell