title: Efficacy of a milbemycin oxime-praziquantel combination product against adult and immature stages of Toxocara cati in cats and kittens after induced infection.
abstract: Two studies were performed to examine the efficacy of milbemycin oxime against fourth-stage larvae or adults of Toxocara cati. In the study to determine efficacy against fourth-stage larvae, 20 domestic shorthair cats were inoculated with 500 embryonated eggs. Four weeks after inoculation, the animals were allocated to two groups, and cats in one group were treated with medicated tablets containing 4 mg milbemycin oxime and 10mg praziquantel (MILBEMAX) and cats in the other group with placebo tablets. Seven days after treatment the animals were euthanatized and necropsied for worm counting. The number of worms found was significantly (p=0.0002) lower in cats treated with medicated tablets than in cats treated with placebo tablets. The reduction in the number of worms was 96.53%. In the study to determine efficacy against mature adult worms, 13 kittens were inoculated with T. cati embryonated eggs. On day 45 after inoculation and after the infection had been confirmed through faecal examinations for 11 out of the 13 animals, the 11 infected animals were allocated to two groups and treated as in the first study. Seven days after treatment, all animals were euthanatized and necropsied for worm counting. The number of worms found was significantly (p=0.0043) lower in kittens treated with medicated tablets than in kittens treated with placebo tablets. The reduction in the number of worms was 95.90%. No adverse effects were recorded during either study. It is concluded that the milbemycin oxime-praziquantel tablets that were used are efficacious for the control of T. cati infections in cats.
authors.affiliation: Novartis Animal Health Inc, CH-4002 Basel, Switzerland.
authors.forename: R
authors.initials: R
authors.lastname: Schenker
authors.forename: D
authors.initials: D
authors.lastname: Bowman
authors.forename: C
authors.initials: C
authors.lastname: Epe
authors.forename: R
authors.initials: R
authors.lastname: Cody
authors.forename: W
authors.initials: W
authors.lastname: Seewald
authors.forename: G
authors.initials: G
authors.lastname: Strehlau
authors.forename: P
authors.initials: P
authors.lastname: Junquera
mesh_terms: D000375:Aging; D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage / Q000627:therapeutic use*; D002371:Cat Diseases / Q000188:drug therapy*; D002415:Cats; D004338:Drug Combinations; D005243:Feces / Q000469:parasitology; D005260:Female; D018942:Macrolides / Q000008:administration & dosage* / Q000627:therapeutic use*; D008297:Male; D011223:Praziquantel / Q000008:administration & dosage* / Q000627:therapeutic use*; D014120:Toxocariasis / Q000188:drug therapy*
chemical_list: D000871:Anthelmintics; D004338:Drug Combinations; D018942:Macrolides; C078973:milbemycin oxime; D011223:Praziquantel