title: Yacht-maker's lung: A case of hypersensitivity pneumonitis in yacht manufacturing.
abstract: We present a case of hypersensitivity pneumonitis in a 46-year-old female working at a yacht manufacturing company. She reported a 2-month history of progressive dyspnea, chest tightness, and daytime, nocturnal, and exertional cough in temporal relationship to work where she was exposed to chemicals involved in the manufacture of yachts. Treatment with systemic antibiotic therapy, inhaled bronchodilators, and inhaled corticosteroids provided minimal relief of symptoms. Spirometry revealed a restrictive defect and a chest x-ray demonstrated a diffuse interstitial pattern. She improved on oral corticosteroids and with avoidance of her work environment had resolution of her symptoms and normalization of her spirometry. Among the various chemicals the patient was exposed to, the most likely causative agents for her symptoms were dimethyl phthalate and styrene. Although the specific chemical or antigen could not be determined, the history and objective findings are consistent with occupational hypersensitivity pneumonitis. This represents a case of hypersensitivity pneumonitis related to the manufacture of yachts.
authors.affiliation: Section of Allergy and Immunology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
authors.forename: Kristen K
authors.initials: KK
authors.lastname: Volkman
authors.forename: James G
authors.initials: JG
authors.lastname: Merrick
authors.forename: Michael C
authors.initials: MC
authors.lastname: Zacharisen
mesh_terms: D000542:Alveolitis, Extrinsic Allergic / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008875:Middle Aged; D010795:Phthalic Acids / Q000633:toxicity; D012129:Respiratory Function Tests; D012767:Ships; D020058:Styrene / Q000633:toxicity
chemical_list: D010795:Phthalic Acids; C024629:dimethyl phthalate; D020058:Styrene