The untranslated regions of genes from Trypanosoma cruzi: perspectives for functional characterization of strains and isolates.
The sequencing of Trypanosoma cruzi genome has been completed and a great deal of information is now available. However, the organization of protozoa genomes is somewhat elusive and much effort must be applied to reveal all the information coded in the nucleotide sequences. Among the DNA segments that needs further investigation are the untranslated regions of genes. Many of the T. cruzi genes that were revealed by the genome sequencing lack information about the untranslated regions. In this paper, some features of these untranslated segments as well as their applications in T. cruzi populations are discussed.
Brandão
Adeilton
A
Departamento de Medicina Tropical, Instituto Oswaldo Cruz-Fiocruz, 21045-900 Rio de Janeiro, RJ, Brazil. abrandao@fiocruz.br
D000818:Animals; D002147:Calmodulin / Q000737:chemistry / Q000235:genetics; D017125:Genes, Protozoan / Q000235:genetics*; D009154:Mutation; D014349:Trypanosoma cruzi / Q000235:genetics*; D020506:Untranslated Regions / Q000737:chemistry / Q000235:genetics*
D002147:Calmodulin; D020506:Untranslated Regions