Crystal structure and DNA interaction of the facial-type rac-tris[2-(aminomethyl)benzimidazole]cobalt(III) complex.
rac-[Co(ambi)3]Cl3.3H2O corresponds to a tris-chelate complex bearing 2-(aminomethyl)benzimidazole (ambi) ligands bound to the Co(III) ion in a facial-type fashion. The high metal q/r ratio and electronic delocalization between coordination heterocyclic functionalities can provide powerful tools to minimize DNA condensation, which arises from the neutralization of the negatively charged sugar phosphate backbone in the presence of multivalent [Co(ambi)3]3+.
Gómez-Segura
Jordi
J
Departament de Química Inorgànica, Universitat de Barcelona, Martí i Franquès 1-11, Departament de Microbiologia, Universitat de Barcelona, Diagonal 645, Spain.
Prieto
María José
MJ
Font-Bardia
Mercè
M
Solans
Xavier
X
Moreno
Virtudes
V
D002614:Chelating Agents / Q000737:chemistry* / Q000378:metabolism; D018360:Crystallography, X-Ray; D004247:DNA / Q000737:chemistry* / Q000378:metabolism; D018625:Microscopy, Atomic Force; D009690:Nucleic Acid Conformation; D009942:Organometallic Compounds / Q000737:chemistry* / Q000378:metabolism; D013237:Stereoisomerism; D013403:Sugar Phosphates / Q000737:chemistry / Q000378:metabolism
D002614:Chelating Agents; D009942:Organometallic Compounds; D013403:Sugar Phosphates; C516722:tris(2-(aminomethyl)benzimidazole)cobalt(III); D004247:DNA