Deletion of the Trypanosoma brucei superoxide dismutase gene sodb1 increases sensitivity to nifurtimox and benznidazole.
It has been more than 25 years since it was first reported that nifurtimox and benznidazole promote superoxide production in trypanosomes. However, there has been no direct evidence of an association between the drug-induced free radicals and trypanocidal activity. Here, we identify a superoxide dismutase required to protect Trypanosoma brucei from drug-generated superoxide.
Prathalingham
S Radhika
SR
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London WC1E 7HT, United Kingdom.
Wilkinson
Shane R
SR
Horn
David
D
Kelly
John M
JM
D000818:Animals; D017353:Gene Deletion; D017125:Genes, Protozoan; D009547:Nifurtimox / Q000494:pharmacology*; D009593:Nitroimidazoles / Q000493:pharmacokinetics*; D021261:Parasitic Sensitivity Tests; D013482:Superoxide Dismutase / Q000235:genetics*; D014346:Trypanosoma brucei brucei / Q000187:drug effects* / Q000201:enzymology / Q000235:genetics*
D009593:Nitroimidazoles; D013482:Superoxide Dismutase; D009547:Nifurtimox; C009999:benzonidazole