title: Antiinflammatory activity of ethanol extracts of Hypericum perforatum L., H. barbatum Jacq., H. hirsutum L., H. richeri Vill. and H. androsaemum L. in rats.
abstract: Ethanol extracts of the aerial parts of six Hypericum species, H. barbatum, H. androsaemum, H. richerii, H. hirsutum, H. perforatum and H. perforatum cultivated on mountain Tara were tested for antiinflammatory activity in comparison with indomethacin (IND) using the carrageenan-induced rat paw edema test. It was found that all examined extracts produced antiinflammatory activity, particularly those from H. hirsutum, and both wild and cultivated H. perforatum. A dose-dependent antiinflammatory effect was especially pronounced in extracts showing some lower antiinflammatory activity. There was no correlation between the amount of hypericin in the extracts and their antiinflammatory activity.
authors.affiliation: Institute for Medicinal Plants Research, Tadeusa Kosćuska 1, 11000 Belgrade, Serbia and Montenegro. ksavikin@iplb.co.yu
authors.forename: Katarina
authors.initials: K
authors.lastname: Savikin
authors.forename: Silva
authors.initials: S
authors.lastname: Dobrić
authors.forename: Vanja
authors.initials: V
authors.lastname: Tadić
authors.forename: Gordana
authors.initials: G
authors.lastname: Zdunić
mesh_terms: D000818:Animals; D000873:Anthracenes; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000737:chemistry; D020902:Hypericum / Q000737:chemistry*; D007213:Indomethacin / Q000494:pharmacology; D010569:Perylene / Q000031:analogs & derivatives / Q000032:analysis; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D051381:Rats
chemical_list: D000873:Anthracenes; D000893:Anti-Inflammatory Agents; D010936:Plant Extracts; D000431:Ethanol; D010569:Perylene; C004965:hypericin; D007213:Indomethacin