title: Progression from impaired fasting glucose and impaired glucose tolerance to diabetes in a high-risk screening programme in general practice: the ADDITION Study, Denmark.
abstract: OBJECTIVE
  To estimate the 1-year progression rates from both IFG and IGT to diabetes in individuals identified in a pragmatic diabetes screening programme in general practice (the ADDITION Study, Denmark [Anglo-Danish-Dutch Study of Intensive Treatment in People with Screen-Detected Diabetes in Primary Care]).
  
  
  METHODS
  Persons aged 40-69 years were screened for type 2 diabetes based on a high-risk, stepwise strategy. At baseline, anthropometric measurements, blood samples and questionnaire data were collected. A total of 1,160 persons had IFG or IGT at baseline: 811 (70%) accepted re-examination after 1 year. Glucose tolerance classification was based on the 1999 WHO definition. At follow-up, diabetes was based on one diabetic glucose value of fasting blood glucose or 2-h blood glucose.
  
  
  RESULTS
  At baseline, 308 persons had IFG and 503 had IGT. The incidence of diabetes was 17.6 and 18.8 per 100 person-years in the two groups, respectively.
  
  
  CONCLUSIONS
  IFG and IGT identified in general practice during a stepwise, high-risk screening programme for type 2 diabetes have high 1-year progression rates to diabetes. Consequently, intensive follow-up and intervention strategies are recommended for these high-risk individuals.
authors.affiliation: Steno Diabetes Center, Niels Steensensvej 2, DK-2820, Gentofte, Denmark. SSSR@steno.dk
authors.forename: S S
authors.initials: SS
authors.lastname: Rasmussen
authors.forename: C
authors.initials: C
authors.lastname: Glümer
authors.forename: A
authors.initials: A
authors.lastname: Sandbaek
authors.forename: T
authors.initials: T
authors.lastname: Lauritzen
authors.forename: K
authors.initials: K
authors.lastname: Borch-Johnsen
mesh_terms: D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D003718:Denmark / Q000453:epidemiology; D003920:Diabetes Mellitus / Q000453:epidemiology* / Q000235:genetics; D018450:Disease Progression; D005194:Family Practice / Q000706:statistics & numerical data; D018149:Glucose Intolerance / Q000453:epidemiology* / Q000503:physiopathology*; D006801:Humans; D008403:Mass Screening; D008875:Middle Aged; D012307:Risk Factors
chemical_list: D001786:Blood Glucose