Hyperbaric oxygen and bone marrow-derived endothelial progenitor cells in diabetic wound healing.
Endothelial progenitor cells (EPCs) are the key cellular effectors of postnatal vasculogenesis and play a central role in wound healing. In diabetes, there is a significant impairment in the number and function of circulating and wound-tissue EPC. Recent evidence indicates, that tissue-level hyperoxia achieved by therapeutic hyperbaric oxygen protocols (HBO2) can increase the mobilization of EPC from the bone marrow into peripheral blood. In this paper we review the recent reports on hyperoxia-mediated mobilization of bone marrow-derived EPC and postulate avenues of future research in this area as it applies to improving healing in chronic wounds affected by diabetes and peripheral arterial disease (PAD).
Gallagher
Katherine A
KA
Department of Surgery, Institute for Environmental Medicine, University of Pennsylvania Medical Center, Philadelphia 19124, USA.
Goldstein
Lee J
LJ
Thom
Stephen R
SR
Velazquez
Omaida C
OC
D000818:Animals; D001854:Bone Marrow Cells / Q000201:enzymology / Q000378:metabolism / Q000473:pathology*; D002465:Cell Movement; D003920:Diabetes Mellitus / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*; D017719:Diabetic Foot / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*; D042783:Endothelial Cells / Q000201:enzymology / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D006931:Hyperbaric Oxygenation; D051379:Mice; D018919:Neovascularization, Physiologic; D009569:Nitric Oxide / Q000378:metabolism; D019001:Nitric Oxide Synthase / Q000378:metabolism; D016491:Peripheral Vascular Diseases / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D016896:Treatment Outcome; D014945:Wound Healing
D009569:Nitric Oxide; D019001:Nitric Oxide Synthase