title: Lovastatin possesses a fungistatic effect against Candida albicans, but does not trigger apoptosis in this opportunistic human pathogen.
abstract: Lovastatin inhibited the growth of Candida albicans in a fungistatic way. Although it triggers apoptosis in a great variety of eukaryotic cells, including many tumour cell lines, lovastatin failed to provoke apoptotic events in this human pathogen. The fungistatic behaviour of this statin might arise from its negative influence on membrane fluidity. Because yeast-->pseudomycelium and hyphae morphogenetic transitions took place under exposure to lovastatin morphogenetic switch and apoptotic cell death must be regulated independently in C. albicans.
authors.affiliation: Department of Microbiology and Biotechnology, Faculty of Science, University of Debrecen, Debrecen, Hungary.
authors.forename: Agnes
authors.initials: A
authors.lastname: Gyetvai
authors.forename: Tamás
authors.initials: T
authors.lastname: Emri
authors.forename: Krisztina
authors.initials: K
authors.lastname: Takács
authors.forename: Tímea
authors.initials: T
authors.lastname: Dergez
authors.forename: Andrea
authors.initials: A
authors.lastname: Fekete
authors.forename: Miklós
authors.initials: M
authors.lastname: Pesti
authors.forename: István
authors.initials: I
authors.lastname: Pócsi
authors.forename: Béla
authors.initials: B
authors.lastname: Lenkey
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D002176:Candida albicans / Q000187:drug effects* / Q000254:growth & development; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D053938:DNA Fragmentation / Q000187:drug effects; D004271:DNA, Fungal / Q000187:drug effects; D006801:Humans; D008148:Lovastatin / Q000494:pharmacology*
chemical_list: D000935:Antifungal Agents; D004271:DNA, Fungal; D008148:Lovastatin