New findings from the Bipolar Collaborative Network: clinical implications for therapeutics.
In this article, we highlight recent Bipolar Collaborative Network data. We found that childhood-onset bipolar illness is common, often goes untreated for more than a decade, and carries a poor prognosis. During randomized studies of adjunctive medications in depression: 1) Venlafaxine showed higher switch rates than bupropion or sertraline; 2) Tranylcypromine was as well tolerated as lamotrigine; and 3) Modafinil was more effective than placebo. Finally, in treatment of overweight and obesity, topiramate and sibutramine showed equal efficacy but poor tolerability, and zonisamide data showed that it may be useful for mood and weight loss.
Post
Robert M
RM
Penn State College of Medicine, Hershey, PA, USA. robert.post@speakeasy.net
Altshuler
Lori L
LL
Frye
Mark A
MA
Suppes
Trisha
T
McElroy
Susan
S
Keck
Paul E
PE
Leverich
Gabriele S
GS
Kupka
Ralph
R
Nolen
Willem A
WA
Grunze
Heinz
H
D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects / Q000627:therapeutic use*; D000928:Antidepressive Agents / Q000009:adverse effects / Q000627:therapeutic use*; D018692:Antimanic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001714:Bipolar Disorder / Q000175:diagnosis / Q000188:drug therapy* / Q000523:psychology; D002648:Child; D003865:Major Depressive Disorder / Q000175:diagnosis / Q000188:drug therapy / Q000523:psychology; D003937:Diagnosis, Differential; D006801:Humans; D011379:Prognosis
D000927:Anticonvulsants; D000928:Antidepressive Agents; D018692:Antimanic Agents