title: [Rofecoxib-induced psychosis].
abstract: Acute psychosis is a possible side effect of many centrally acting drugs. Its appearance is facilitated by certain conditions like advanced age, comedication, or comorbidity. We report two cases of acute psychotic syndromes with visual (Case 1 + 2) and auditory (Case 1) hallucinations under rofecoxib, a cyclooxygenase-2-inhibitor. This is one of the first reports of psychotic disorders under rofecoxib intake. We present a review of the literature on mental side effects of NSAID and on the pharmacological basis of the association of cyclooxygenase-inhibitors and mental disorders.
authors.affiliation: Neurologische Klinik der Universität Ulm (Direktor: Prof. Dr. med. A. C. Ludolph). michael.sabolek@uni-ulm.de
authors.forename: Michael
authors.initials: M
authors.lastname: Sabolek
authors.forename: Alexander
authors.initials: A
authors.lastname: Unrath
authors.forename: Anne-Dorte
authors.initials: AD
authors.lastname: Sperfeld
authors.forename: Bernhard J
authors.initials: BJ
authors.lastname: Connemann
authors.forename: Jan
authors.initials: J
authors.lastname: Kassubek
mesh_terms: D000368:Aged; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D016861:Cyclooxygenase Inhibitors / Q000627:therapeutic use / Q000633:toxicity*; D005260:Female; D005500:Follow-Up Studies; D006212:Hallucinations / Q000139:chemically induced* / Q000175:diagnosis; D006801:Humans; D007783:Lactones / Q000627:therapeutic use / Q000633:toxicity*; D008297:Male; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000188:drug therapy*; D011605:Psychoses, Substance-Induced / Q000175:diagnosis / Q000209:etiology*; D012075:Remission, Spontaneous; D013450:Sulfones / Q000627:therapeutic use / Q000633:toxicity*
chemical_list: D016861:Cyclooxygenase Inhibitors; D007783:Lactones; D013450:Sulfones; C116926:rofecoxib