title: Phase transfer catalyzed enantioselective Strecker reactions of alpha-amido sulfones with cyanohydrins.
abstract: A study into the use of a chiral phase-transfer catalyst in conjunction with acetone cyanohydrin to effect the enantioselective formation of alpha-amino nitriles from alpha-amido sulfones is described. This novel catalytic asymmetric Strecker reaction is analyzed with regard to the possible mechanistic basis.
authors.affiliation: Department of Organic Chemistry A. Mangini, University of Bologna, V. Risorgimento 4, 40136 Bologna, Italy. rph@alu.ua.es
authors.forename: Raquel P
authors.initials: RP
authors.lastname: Herrera
authors.forename: Valentina
authors.initials: V
authors.lastname: Sgarzani
authors.forename: Luca
authors.initials: L
authors.lastname: Bernardi
authors.forename: Francesco
authors.initials: F
authors.lastname: Fini
authors.forename: Daniel
authors.initials: D
authors.lastname: Pettersen
authors.forename: Alfredo
authors.initials: A
authors.lastname: Ricci
mesh_terms: D002254:Carbonates / Q000737:chemistry; D002384:Catalysis; D015394:Molecular Structure; D009570:Nitriles / Q000138:chemical synthesis* / Q000737:chemistry; D044367:Phase Transition; D011188:Potassium / Q000737:chemistry; D013237:Stereoisomerism; D013450:Sulfones / Q000737:chemistry*; D014867:Water / Q000737:chemistry
chemical_list: D002254:Carbonates; D009570:Nitriles; D013450:Sulfones; C430593:cyanohydrin; D014867:Water; C037593:potassium carbonate; D011188:Potassium