Reduction of right medial pulvinar volume and neuron number in schizophrenia.
Several studies have described a reduction of pulvinar volume and/or neuronal number in schizophrenia (SZ). In order to better localize these changes, we assessed volume and neuronal number of the pulvinar and several of its subdivisions in postmortem material from subjects with chronic SZ and subjects with no psychiatric history. Total pulvinar volume and neuronal number were significantly lower in SZ and these differences were significant in only in its medial division. The medial pulvinar interconnects various heteromodal cortical regions suggesting that these deficits may contribute to the abnormalities of higher order integrative functions characteristic of schizophrenia.
Byne
William
W
Division of Basic and Laboratory Research, Bronx Veterans Affairs Medical Center, Bronx, NY 10467, USA. william.byne@mssm.edu
Fernandes
Jason
J
Haroutunian
Vhram
V
Huacon
Dennis
D
Kidkardnee
Smith
S
Kim
John
J
Tatusov
Alex
A
Thakur
Uma
U
Yiannoulos
Georgia
G
D000368:Aged; D000369:Aged, 80 and over; D002452:Cell Count; D004292:Dominance, Cerebral / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009474:Neurons / Q000473:pathology; D020649:Pulvinar / Q000473:pathology*; D012016:Reference Values; D012559:Schizophrenia / Q000473:pathology*; D013223:Statistics as Topic