Androgen receptor coregulators and their involvement in the development and progression of prostate cancer.
The androgen receptor signaling axis plays an essential role in the development, function and homeostasis of male urogenital structures including the prostate gland although the mechanism by which the AR axis contributes to the initiation, progression and metastatic spread of prostate cancer remains somewhat enigmatic. A number of molecular events have been proposed to act at the level of the AR and associated coregulators to influence the natural history of prostate cancer including deregulated expression, somatic mutation, and post-translational modification. The purpose of this article is to review the evidence for deregulated expression and function of the AR and associated coactivators and corepressors and how such events might contribute to the progression of prostate cancer by controlling the selection and expression of AR targets.
Chmelar
Renée
R
Department of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Buchanan
Grant
G
Need
Eleanor F
EF
Tilley
Wayne
W
Greenberg
Norman M
NM
D000818:Animals; D018450:Disease Progression; D051548:Histone Acetyltransferases / Q000378:metabolism*; D006801:Humans; D008297:Male; D056920:Nuclear Receptor Coactivator 1; D011471:Prostatic Neoplasms / Q000235:genetics / Q000378:metabolism*; D011944:Receptors, Androgen / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction; D025841:Small Ubiquitin-Related Modifier Proteins / Q000378:metabolism; D014157:Transcription Factors / Q000378:metabolism*
D011944:Receptors, Androgen; D025841:Small Ubiquitin-Related Modifier Proteins; D014157:Transcription Factors; D051548:Histone Acetyltransferases; C538859:NCOA1 protein, human; D056920:Nuclear Receptor Coactivator 1