Postevacuation hCG levels and risk of gestational trophoblastic neoplasia among women with partial molar pregnancies.
OBJECTIVE
To develop human chorionic gonadotropin (hCG) criteria that determine a patient's risk of developing persistent gestational trophoblastic neoplasia (GTN) or achieving remission after partial mole evacuation.


METHODS
We used a database from the New England Trophoblastic Disease Center to analyze hCG levels from 284 women with partial molar pregnancies diagnosed between 1973 and 2003.


RESULTS
An hCG level >199 mIU/mL in the third through eighth week following molar evacuation was associated with at least a 35% risk of GTN.


CONCLUSIONS
Women with partial mole who have elevated hCG levels within the first few weeks after molar evacuation are at increased risk for developing GTN.
Growdon
Whitfield B
WB
Donald P. Goldstein, M.D., Trophoblastic Tumor Registry, New England Trophoblastic Disease Center, USA.
Wolfberg
Adam J
AJ
Feltmate
Colleen M
CM
Goldstein
Donald P
DP
Genest
David R
DR
Chinchilla
Manuel E
ME
Berkowitz
Ross S
RS
Lieberman
Ellice S
ES
D014408:Biomarkers, Tumor / Q000097:blood*; D006063:Chorionic Gonadotropin / Q000097:blood*; D005260:Female; D031901:Gestational Trophoblastic Disease / Q000209:etiology*; D006801:Humans; D006828:Hydatidiform Mole / Q000097:blood / Q000150:complications*; D011247:Pregnancy; D012189:Retrospective Studies; D012306:Risk
D014408:Biomarkers, Tumor; D006063:Chorionic Gonadotropin