Torsade de pointes induced by short-term oral amiodarone therapy.
Although amiodarone appears to have few pro-arrhythmic effects, torsade de pointes (TdP) has been observed during long-term drug administration, usually in conjunction with electrolyte disturbances, a change in drug dosage, or concomitant drug therapy. We report two cases of amiodarone-induced TdP shortly after administration of a low dose of oral amiodarone, in the absence of predisposing factors.
Lim
Hong Euy
HE
Division of Cardiology, Korea University Cardiovascular Center, Ansan Hospital, 516 Gojan-1-Dong, Danwon-ku, Ansan 425-707, Republic of Korea. hongeuy@korea.ac.kr
Pak
Hui-Nam
HN
Ahn
Jeong Cheon
JC
Song
Woo Hyuk
WH
Kim
Young-Hoon
YH
D000284:Administration, Oral; D000328:Adult; D000369:Aged, 80 and over; D000638:Amiodarone / Q000008:administration & dosage / Q000009:adverse effects*; D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage / Q000009:adverse effects*; D001281:Atrial Fibrillation / Q000150:complications* / Q000188:drug therapy / Q000503:physiopathology; D009202:Cardiomyopathies / Q000150:complications* / Q000188:drug therapy / Q000503:physiopathology; D003324:Coronary Artery Disease / Q000150:complications* / Q000188:drug therapy / Q000503:physiopathology; D005260:Female; D006801:Humans; D013575:Syncope / Q000150:complications* / Q000188:drug therapy / Q000503:physiopathology; D013997:Time Factors; D016171:Torsades de Pointes / Q000139:chemically induced* / Q000188:drug therapy / Q000503:physiopathology
D000889:Anti-Arrhythmia Agents; D000638:Amiodarone