[Oxaliplatin in combination with calcium folinate and fluorouracil as neoadjuvant chemotherapy in the treatment of advanced gastric cancer].
OBJECTIVE
To evaluate the efficacy and toxicity of oxaliplatin in combination with calcium folinate and fluorouracil (OXA-LV5FU2) regimen as the neoadjuvant chemotherapy in the treatment of patients with advanced gastric cancer.


METHODS
Twenty-seven patients were treated with OXA-LV5FU2 before operation. Neoadjuvant chemotherapy regimens containing OXA 100 mg/m(2) iv 2 h d1, LV 200 mg/m(2) iv 2 h followed by 5-FU 400 mg/m(2) iv bolus and 5-FU 1 g/m(2) iv 48-72 h d1, 2 were administered every 2 to 3 weeks for 3 to 4 cycles before local treatment. The responses of the primary tumor and the chemotherapy toxicity were observed in each patient.


RESULTS
Twenty-four patients were treated with surgery. The radical resections were carried out in 14 cases. The overall clinical efficacy rate was 48.1% with 3.7% CR and 44.4% PR, SD was 33.3% and PD was 18.5%. Eight of the 27 cases were downstaged. The common toxicities were nausea, vomiting, peripheral neuropathy, leukocytopenia, alopecia and hepatosis. The toxicities relieved after symptomatic treatment. There was no relative risk of death during treatment.


CONCLUSIONS
OXA-LV5FU2 is a very effective and well tolerated regimen as neoadjuvant chemotherapy for advanced gastric cancer.
Fang
Yu
Y
Department of General Surgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, China. wyjwmj@yahoo.com.cn
Wang
Ya-jun
YJ
Li
Fei
F
Li
Jia
J
D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use*; D006801:Humans; D002955:Leucovorin / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D009367:Neoplasm Staging; D009944:Organoplatinum Compounds / Q000627:therapeutic use*; D000077150:Oxaliplatin; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology
D009944:Organoplatinum Compounds; D000077150:Oxaliplatin; D002955:Leucovorin; D005472:Fluorouracil