Peripheral nervous system involvement in patients with cancer.
Involvement of the peripheral nervous system (PNS) is common in patients with cancer and any part, including motor neurons, sensory ganglia, nerve roots, plexuses, cranial and peripheral nerves, and neuromuscular junctions, can be affected. Different mechanisms can initiate damage associated with cancer-related PNS disorders. These include tumour infiltration, toxicity of treatments, metabolic and nutritional perturbations, cachexia, virus infections, and paraneoplastic neurological syndromes. The type of cancer, lymphoma, or solid tumour is a further determinant of a PNS disorder. In this Review we discuss the different causes and mechanisms of disorders of the PNS in patients with cancer and we will focus on their assessment and diagnosis.
Antoine
Jean-Christophe
JC
Service de Neurologie, Hôpital Bellevue, CHU de Saint-Etienne. j.christophe.antoine@chu-st-etienne.fr
Camdessanché
Jean-Philippe
JP
D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D009369:Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D020361:Paraneoplastic Syndromes, Nervous System / Q000175:diagnosis / Q000473:pathology; D010523:Peripheral Nervous System Diseases / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology; D010524:Peripheral Nervous System Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000556:secondary*
D000970:Antineoplastic Agents