Enzymatic formation of quinolone alkaloids by a plant type III polyketide synthase.
[Structure: see text] Benzalacetone synthase from Rheum palmatum efficiently catalyzed condensation of N-methylanthraniloyl-CoA (or anthraniloyl-CoA) with malonyl-CoA (or methylmalonyl-CoA) to produce 4-hydroxy-2(1H)-quinolones, a novel alkaloidal scaffold produced by a type III polyketide synthase (PKS). Manipulation of the functionally divergent type III PKSs by a nonphysiological substrate thus provides an efficient method for production of pharmaceutically important quinolone alkaloids.
Abe
Ikuro
I
School of Pharmaceutical Sciences and the COE 21 Program, University of Shizuoka, Shizuoka 422-8526, Japan. abei@ys7.u-shizuoka-ken.ac.jp
Abe
Tsuyoshi
T
Wanibuchi
Kiyofumi
K
Noguchi
Hiroshi
H
D000470:Alkaloids / Q000737:chemistry*; D048630:Polyketide Synthases / Q000378:metabolism*; D015363:Quinolones / Q000737:chemistry*; D012250:Rheum / Q000201:enzymology*
D000470:Alkaloids; D015363:Quinolones; D048630:Polyketide Synthases