title: Arylamine N-acetyltransferase responsible for acetylation of 2-aminophenols in Streptomyces griseus.
abstract: An arylamine N-acetyltransferase (NAT) responsible for the N acetylation of exogenous 3-amino-4-hydroxybenzoic acid in Streptomyces griseus was identified and characterized. This enzyme was distinct from other eukaryotic and bacterial NATs in that it acetylated various 2-aminophenol derivatives more effectively than it acetylated 5-aminosalicylic acid, and thus it may be involved in the metabolism of xenobiotic compounds.
authors.affiliation: Department of Biotechnology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan.
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Suzuki
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Ohnishi
authors.forename: Sueharu
authors.initials: S
authors.lastname: Horinouchi
mesh_terms: D000107:Acetylation; D062365:Aminobenzoates / Q000378:metabolism*; D000627:Aminophenols / Q000378:metabolism*; D001191:Arylamine N-Acetyltransferase / Q000235:genetics / Q000502:physiology*; D001483:Base Sequence; D004926:Escherichia coli / Q000235:genetics; D062385:Hydroxybenzoates; D008969:Molecular Sequence Data; D011994:Recombinant Proteins / Q000096:biosynthesis; D013305:Streptomyces griseus / Q000378:metabolism*; D013379:Substrate Specificity
chemical_list: D062365:Aminobenzoates; D000627:Aminophenols; D062385:Hydroxybenzoates; D011994:Recombinant Proteins; C110924:3-amino-4-hydroxybenzoic acid; C027667:2-aminophenol; D001191:Arylamine N-Acetyltransferase