PU.1 and Junb: suppressing the formation of acute myeloid leukemia stem cells.
Improved understanding of the molecular pathways that suppress the genesis and maintenance of cancer stem cells will facilitate development of rationally targeted therapies. PU.1 is a transcription factor that is required for normal myelomonocytic differentiation in hematopoiesis, and reduced PU.1 activity has been associated with myeloid leukemogenesis in man and in mouse models. A recent study by Steidl et al. demonstrates that Junb and Jun, two AP-1 transcription factors, are critical downstream effectors of the tumor suppressor activity of PU.1, and that reduced expression of Junb, in particular, may be a common feature of acute myeloid leukemogenesis.
Somervaille
Tim C P
TC
Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA.
Cleary
Michael L
ML
D000818:Animals; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000517:prevention & control*; D051379:Mice; D014411:Neoplastic Stem Cells / Q000502:physiology*; D011518:Proto-Oncogene Proteins / Q000502:physiology*; D016755:Proto-Oncogene Proteins c-jun / Q000502:physiology*; D015534:Trans-Activators / Q000502:physiology*; D025521:Tumor Suppressor Proteins / Q000502:physiology*; D000099232:Proto-Oncogene Protein Spi-1
D011518:Proto-Oncogene Proteins; D016755:Proto-Oncogene Proteins c-jun; D015534:Trans-Activators; D025521:Tumor Suppressor Proteins; D000099232:Proto-Oncogene Protein Spi-1