title: [Morphometric analysis of the palpebral fissure in patients with thyroid-related disfunction before and after application of botulinum toxin].
abstract: BACKGROUND
  Botulinum toxin is an alternative treatment for retraction of ocular thyroid related dysfunction. The aim of this study was to evaluate the effects of this medication on upper lid position, levator palpebrae superioris muscle function and corneal exposure.
  
  
  METHODS
  Seven patients were enrolled into the study. The palpebral fissure images were acquired by a digital camera and transferred to a computer video edition program in order to be processed and analyzed. The levator palpebrae superioris muscle function and lacrimal film tests were also studied.
  
  
  RESULTS
  The distance between upper eyelid superior margin and light reflection on the center of the cornea had a significantly reduction in its measurements after toxin injection. The muscle function was diminished and there were improvement in corneal exposure after treatment.
  
  
  CONCLUSIONS
  Botulinum toxin injection could be an alternative treatment for upper eyelid retraction; it may relieve symptoms and improve eye appearance.
authors.affiliation: Departamento de Otorrinolaringologia e Oftalmologia, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, SP. patriciagrativol@yahoo.com.br
authors.forename: Patrícia Grativol
authors.initials: PG
authors.lastname: Costa
authors.forename: Fábio Petersen
authors.initials: FP
authors.lastname: Saraiva
authors.forename: Suzana
authors.initials: S
authors.lastname: Matayoshi
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D019274:Botulinum Toxins, Type A / Q000627:therapeutic use*; D003941:Diagnostic Techniques, Ophthalmological; D005141:Eyelid Diseases / Q000188:drug therapy / Q000473:pathology*; D005143:Eyelids / Q000187:drug effects*; D005260:Female; D049970:Graves Ophthalmopathy / Q000188:drug therapy / Q000473:pathology*; D006801:Humans; D008875:Middle Aged; D009465:Neuromuscular Agents / Q000627:therapeutic use*; D013666:Tears / Q000187:drug effects / Q000378:metabolism; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D009465:Neuromuscular Agents; D019274:Botulinum Toxins, Type A