Myocardial ischemia and ventricular fibrillation: pathophysiology and clinical implications.
Ventricular fibrillation (VF) and myocardial ischemia are inseparable. The first clinical manifestation of myocardial ischemia or infarction may be sudden cardiac death in 20-25% of patients. The occurrence of potentially lethal arrhythmia is the end result of a cascade of pathophysiological abnormalities that result from complex interactions between coronary vascular events, myocardial injury, and changes in autonomic tone, metabolic conditions and ionic state of the myocardium. It is also related to the time from the onset of ischemia. Within the first few minutes there is abundant ventricular arrhythmogenesis usually lasting for 30 min. Triggers for ischemic VF occur at the border zone or regionally ischemic heart. The border zone of ischemia is the predominant site of fragmentation. Acute ischemia opens K(ATP) channels and causes acidosis and hypoxia of myocardial cells leading to a large dispersion in repolarization across the border zone. Abnormalities of intracellular Ca2+ handling also occur in the first few minutes of acute myocardial ischemia and may be an important cause of arrhythmias in human coronary artery disease. Substrate on the other hand transforms triggers into VF and serves to maintain it through fragmentation of waves in the ischemic zone. Thrombin levels, stretch, catecholamine, genetic predisposition, etc. are some of these factors. Reentry models described are spiral wave reentry, 3 dimensional rotors, reentry around 'M' cells and figure-of-eight reentry. Continuing efforts to better understand these arrhythmias will help identify patients of myocardial ischemia prone to arrhythmias.
Luqman
Nazar
N
The Department of Cardiology, RIPAS Hospital, Brunei Darussalam.
Sung
Ruey J
RJ
Wang
Chun-Li
CL
Kuo
Chi-Tai
CT
D015220:Calcium Channels / Q000502:physiology; D006801:Humans; D017202:Myocardial Ischemia / Q000150:complications* / Q000503:physiopathology*; D015221:Potassium Channels / Q000502:physiology; D012307:Risk Factors; D014693:Ventricular Fibrillation / Q000209:etiology* / Q000503:physiopathology*
D015220:Calcium Channels; D015221:Potassium Channels