Immunohistochemical localization of endothelial isoform (eNOS) in human cerebral arteries and the aorta.
The common carotid, vertebral, posterior cerebral arteries, and the aorta were studied in the human in terms of its eNOS expression. In around 10 weeks of gestation, the developing intima began to express notable eNOS. In the adult, the positive eNOS sites were in the endothelial cells and the tunica media where the smooth muscles were. In the vessels with athrosclerotic changes, eNOS was down regulated in the endothelial layer and most of the tunica media but was significantly upregulated in the tunica media around the lesion. The protein changes are related to the onset of the athrosclerotic diseases.
Liang
Yong
Y
Institute of Cell Biology, Medical College of Zhejiang University, Hangzhou, Zhejiang, P.R., China.
Fang
Marong
M
Li
Jicheng
J
Yew
David T
DT
D000368:Aged; D001011:Aorta / Q000196:embryology / Q000201:enzymology* / Q000473:pathology; D050197:Atherosclerosis / Q000378:metabolism* / Q000473:pathology; D002536:Cerebral Arteries / Q000196:embryology / Q000201:enzymology* / Q000473:pathology; D004730:Endothelium, Vascular / Q000201:enzymology / Q000473:pathology; D005333:Fetus; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D009131:Muscle, Smooth, Vascular / Q000201:enzymology / Q000473:pathology; D052250:Nitric Oxide Synthase Type III / Q000378:metabolism*; D017540:Tunica Media / Q000201:enzymology / Q000473:pathology
C496314:NOS3 protein, human; D052250:Nitric Oxide Synthase Type III