Hormone effects on fMRI and cognitive measures of encoding: importance of hormone preparation.
We compared fMRI and cognitive data from nine hormone therapy (HT)-naive women with data from women exposed to either opposed conjugated equine estrogens (CEE) (n = 10) or opposed estradiol (n = 4). Exposure to either form of HT was associated with healthier fMRI response; however, CEE-exposed women exhibited poorer memory performance than either HT-naive or estradiol-exposed subjects. These preliminary findings emphasize the need to characterize differential neural effects of various HTs.
Gleason
C E
CE
Section of Geriatrics and Gerontology, Department of Medicine, University of Wisconsin, 2870 University Ave., Suite 106, Madison, WI 53705, USA. ceg@medicine.wisc.edu
Schmitz
T W
TW
Hess
T
T
Koscik
R L
RL
Trivedi
M A
MA
Ries
M L
ML
Carlsson
C M
CM
Sager
M A
MA
Asthana
S
S
Johnson
S C
SC
D003071:Cognition / Q000187:drug effects* / Q000502:physiology; D004958:Estradiol / Q000494:pharmacology*; D015914:Estrogen Replacement Therapy / Q000379:methods; D004966:Estrogens, Conjugated (USP) / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008875:Middle Aged; D017698:Postmenopause / Q000187:drug effects / Q000502:physiology
D004966:Estrogens, Conjugated (USP); D004958:Estradiol