Synthesis and antiviral evaluation of some sugar arylglycinoylhydrazones and their oxadiazoline derivatives.
Sugar N-arylaminoacetylhydrazones 2-5 were prepared by the reaction of N-arylaminoacetylhydrazides 1 with equivalent amounts of the corresponding monosaccharides. Per-O-acetyl derivatives 6-9 of sugar hydrazones 2-5 were prepared by using acetic anhydride in pyridine at room temperature, while on boiling with acetic anhydride, cyclization had taken place to give the oxadiazolines 10-12. The prepared compounds were tested for antiviral activity against Herpes Simplex virus type-1 (HSV-1) and hepatitis-A virus (HAV, MBB-cell culture adapted strain). Plaque reduction infectivity assay was used to determine virus count reduction as a result of treatment with tested compounds.
Abdel-Aal
Mohammed T
MT
Photochemistry Department, National Research Centre, Cairo, Egypt. mtaha2000_2000@yahoo.com
El-Sayed
Wael A
WA
El-Ashry
El-Sayed H
el-SH
D000814:Aniline Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*; D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002522:Chlorocebus aethiops; D004353:Drug Evaluation, Preclinical; D030041:Hepatitis A virus / Q000187:drug effects; D018259:Herpesvirus 1, Human / Q000187:drug effects; D006835:Hydrazones / Q000138:chemical synthesis* / Q000494:pharmacology*; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D010069:Oxadiazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D013055:Spectrophotometry, Infrared; D010948:Viral Plaque Assay
D000814:Aniline Compounds; D000998:Antiviral Agents; D006835:Hydrazones; D007202:Indicators and Reagents; D010069:Oxadiazoles