Hypervirulence of a rough variant of the Mycobacterium abscessus type strain.
We isolated a rough variant of Mycobacterium abscessus CIP 104536T during experimental infection of mice. We show that this variant has lost the ability to produce glycopeptidolipids, is hyperlethal for C57BL/6 mice infected intravenously, and induces a strong tumor necrosis factor-alpha response by murine monocyte-derived macrophages.
Catherinot
E
E
Laboratoire de Microbiologie, Hôpital Raymond Poincaré, 104 Bd Raymond Poincaré, 92380 Garches, France.
Clarissou
J
J
Etienne
G
G
Ripoll
F
F
Emile
J-F
JF
Daffé
M
M
Perronne
C
C
Soudais
C
C
Gaillard
J-L
JL
Rottman
M
M
D000818:Animals; D004195:Disease Models, Animal; D006017:Glycolipids / Q000096:biosynthesis; D006020:Glycopeptides / Q000096:biosynthesis; D008264:Macrophages / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL; D009154:Mutation; D009165:Mycobacterium Infections, Nontuberculous / Q000276:immunology / Q000382:microbiology*; D016926:Mycobacterium chelonae / Q000276:immunology / Q000472:pathogenicity* / Q000502:physiology; D016019:Survival Analysis; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis; D014774:Virulence
D006017:Glycolipids; D006020:Glycopeptides; D014409:Tumor Necrosis Factor-alpha