Role of protein kinase C in the effect of ATP on contractile function of the isolated strip from mouse diaphragm.
We studied the effects of adenosine and ATP on contractile function of the isolated strip from mouse diaphragm. ATP significantly increased the strength of muscle contraction induced by carbachol. Adenosine had no effect on carbachol-induced muscle contraction. P2 receptor antagonist suramin abolished the effect of ATP. The positive chronotropic effect of ATP was not observed after treatment with specific protein kinase C inhibitor chelerythrine. Our results indicate that the effect of ATP on contractile function of mouse diaphragm is realized via protein kinase C.
Teplov
A Yu
AY
Department of Pathophysiology, Pharmaceutical Faculty, Kazan State Medical University. alikteplov@mail.ru
Grishin
S N
SN
Zefirov
A L
AL
Ziganshin
A U
AU
D000241:Adenosine / Q000494:pharmacology; D000255:Adenosine Triphosphate / Q000378:metabolism*; D000470:Alkaloids / Q000378:metabolism; D000818:Animals; D053119:Benzophenanthridines / Q000378:metabolism; D002217:Carbachol / Q000494:pharmacology; D002316:Cardiotonic Agents / Q000494:pharmacology; D003964:Diaphragm / Q000201:enzymology* / Q000378:metabolism; D005260:Female; D008297:Male; D051379:Mice; D009119:Muscle Contraction / Q000502:physiology*; D009132:Muscles / Q000201:enzymology*; D011493:Protein Kinase C / Q000378:metabolism / Q000502:physiology*; D013498:Suramin / Q000494:pharmacology; D014665:Vasodilator Agents / Q000494:pharmacology
D000470:Alkaloids; D053119:Benzophenanthridines; D002316:Cardiotonic Agents; D014665:Vasodilator Agents; D013498:Suramin; D000255:Adenosine Triphosphate; D002217:Carbachol; C016299:chelerythrine; D011493:Protein Kinase C; D000241:Adenosine