Three-dimensional structure of a cyclic-nucleotide phosphodiesterase from human brain.
2',3'-Cyclic-nucleotide 3'-phosphodiesterase (CNP) is found mainly in the central nervous system of vertebrates and catalyzes the hydrolysis of 2',3'-cyclic nucleotides to produce 2'-nucleotides in vitro. Recently, CNP has been identified as a member of the 2H phosphoesterase superfamily. Here we have determined the crystal structure of the catalytic fragment of human CNP (hCNP-CF) at 1.3 A resolution.
Sakamoto
Yasumitsu
Y
School of Pharmaceutical Sciences, Showa University, Tokyo 142-8555, Japan.
Tanaka
Nobutada
N
Ichimiya
Tomomi
T
Kurihara
Tadashi
T
Nakamura
Kazuo T
KT
D015087:2',3'-Cyclic-Nucleotide Phosphodiesterases / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism; D001921:Brain / Q000201:enzymology*; D003460:Crystallization; D018360:Crystallography, X-Ray; D006801:Humans
D015087:2',3'-Cyclic-Nucleotide Phosphodiesterases