title: Liposomal delivery systems for encapsulation of ferrous sulfate: Preparation and characterization.
abstract: Liposomal delivery systems for water-soluble bioactives were prepared using the pro-liposome and the microfluidization technologies. Iron, an essential micronutrient as ferrous sulfate and ascorbic acid, as an antioxidant for iron were encapsulated in the liposomes. Liposomes prepared by the microfluidization technology using 6% (w/w) concentration of the lipid encapsulated with ferrous sulfate and ascorbic acid had particle size distributions around 150 to 200 nm, whereas liposomes from the pro-liposome technology resulted in particle sizes of about 5 microm. The encapsulation efficiency of ferrous sulfate was 58% for the liposomes prepared by the microfluidization using 6% (w/w) lipid and 7.5% of ferrous sulfate concentrations, and it was 11% for the liposomes from pro-liposome technology using 1.5% (w/v) lipid and 15% of ferrous-sulfate concentration. Both the liposomes exhibited similar levels of oxidative stability, demonstrating the feasibility of microfluidization-based liposomal delivery systems for large-scale food/nutraceutical applications.
authors.affiliation: Food Chemistry & Formulation Science, Food Science Australia, Werribee, Victoria, Australia. shantha.kosaraju@csiro.au
authors.forename: Shantha L
authors.initials: SL
authors.lastname: Kosaraju
authors.forename: Cindy
authors.initials: C
authors.lastname: Tran
authors.forename: Andrew
authors.initials: A
authors.lastname: Lawrence
mesh_terms: D016503:Drug Delivery Systems; D005296:Ferrous Compounds; D007501:Iron; D008081:Liposomes; D046529:Microscopy, Electron, Transmission; D010084:Oxidation-Reduction; D010316:Particle Size
chemical_list: D005296:Ferrous Compounds; D008081:Liposomes; C020748:ferrous sulfate; D007501:Iron