title: Evaluation of anxiolytic potential of Celastrus oil in rat models of behaviour.
abstract: The Celastrus oil, extracted from seeds of Celastrus paniculatus tested at 2 dose levels (1 and 1.5 g/kg), exhibited significant anxiolytic activity and did not produce tolerance. The non-sedative nature and reversal of buspirone induced behaviour (in open field exploration) point to the serotonergic mechanism underlying the anxiolysis, inspiring further research.
authors.affiliation: J.S.S. College of Pharmacy, Ooty, India. rajkumarrna@yahoo.com
authors.forename: Ramamoorthy
authors.initials: R
authors.lastname: Rajkumar
authors.forename: Elavarasan Prem
authors.initials: EP
authors.lastname: Kumar
authors.forename: Suresh
authors.initials: S
authors.lastname: Sudha
authors.forename: Bhojraj
authors.initials: B
authors.lastname: Suresh
mesh_terms: D000818:Animals; D014151:Anti-Anxiety Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D001008:Anxiety Disorders / Q000188:drug therapy; D001522:Behavior, Animal / Q000187:drug effects*; D029753:Celastraceae; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D023421:Models, Animal; D008517:Phytotherapy; D010938:Plant Oils / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D012639:Seeds
chemical_list: D014151:Anti-Anxiety Agents; D010938:Plant Oils; C097139:Celastrus oil