Asperpyrone D and other metabolites of the plant-associated fungal strain Aspergillus tubingensis.
Bioactivity-guided fractionation of a cytotoxic extract of Aspergillus tubingensis, a fungal strain occurring in the rhizosphere of the Sonoran desert plant, Fallugia paradoxa, afforded a dimeric naphtho-gamma-pyrone asperpyrone D, nine known naphtho-gamma-pyrones, funalenone, and the cytotoxic cyclic penta-peptide, malformin A1.
Zhan
Jixun
J
Southwest Center for Natural Products Research and Commercialization, Office of Arid Lands Studies, College of Agriculture and Life Sciences, The University of Arizona, 250 East Valencia Road, Tucson, AZ 85706-6800, USA.
Gunaherath
G M Kamal B
GM
Wijeratne
E M Kithsiri
EM
Gunatilaka
A A Leslie
AA
D001230:Aspergillus / Q000378:metabolism*; D045744:Cell Line, Tumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D009281:Naphthalenes / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism*; D010944:Plants / Q000382:microbiology*; D011753:Pyrones / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism*; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared
D009281:Naphthalenes; D011753:Pyrones; C518859:asperpyrone D