title: Convenient synthesis of 3',5'-cyclic diguanylic acid (cdiGMP).
abstract: We herein report a convenient synthesis of 3',5'-cyclic diguanylic acid (cdiGMP) through the modified H-phosphonate chemistry. The 1-(4-chlorophenyl)-4-ethoxypiperidin-4-yl (Cpep) group was used as protecting group for the 2'-hydroxy functions of ribonucleosides. Homogeneous cdiGMP was obtained after removal of the protecting groups.
authors.affiliation: Department of Chemistry, Brock University, 500 Glenridge Ave., St. Catharines, Ontario L2S 3A1, Canada.
authors.forename: Hongbin
authors.initials: H
authors.lastname: Yan
authors.forename: Eric
authors.initials: E
authors.lastname: Humes
mesh_terms: D002851:Chromatography, High Pressure Liquid; D006152:Cyclic GMP / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry
chemical_list: C062025:bis(3',5')-cyclic diguanylic acid; D006152:Cyclic GMP