Neuropsychological profiles of patients with obsessive-compulsive disorder: early onset versus late onset.
In this study, we assess the neuropsychological profiles of both early and late symptom-onset obsessive-compulsive disorder (OCD) patients. The early and late-onset OCD patients are compared to the control group with a series of neuropsychological measurements. The late-onset OCD patients exhibited impaired performance on the immediate and the delayed recall conditions of the Rey-Osterrieth Complex Figure Test (RCFT) and the letter and category fluency of the Controlled Oral Word Association Test (COWA), compared to the normal controls and the early-onset OCD patients. The controls and early-onset OCD patients did not differ on any of the neuropsychological measurements taken in this study. These results suggest that different neurophysiological mechanisms are in play in early and late-onset OCD patients, and age of onset can serve as a potential marker for the subtyping of OCD.
Hwang
Seon Hee
SH
Clinical Research Center, Seoul National University Hospital, Seoul, South Korea.
Kwon
Jun Soo
JS
Shin
Yong-Wook
YW
Lee
Kyung Jin
KJ
Kim
Young Youn
YY
Kim
Myung-Sun
MS
D000328:Adult; D000367:Age Factors; D017668:Age of Onset; D003072:Cognition Disorders / Q000175:diagnosis / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D009771:Obsessive-Compulsive Disorder / Q000175:diagnosis / Q000453:epidemiology* / Q000523:psychology; D012720:Severity of Illness Index