title: Are genome-wide association studies all that we need to dissect the genetic component of complex human diseases?
abstract: With the availability of dense maps of anonymous and frequent SNPs spanning the whole human genome, genome-wide association studies are now becoming a reality. In this paper, we discuss the utility of these approaches to detect genetic risk variants involved in complex disease susceptibility and, in the best case scenario where a signal is detected, how helpful it will be to the understanding of the pathological process.
authors.affiliation: 1INSERM U535, University Paris Sud, Villejuif F-94817, France. bourgain@vjf.inserm.fr
authors.forename: Catherine
authors.initials: C
authors.lastname: Bourgain
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Génin
authors.forename: Nancy
authors.initials: N
authors.lastname: Cox
authors.forename: Françoise
authors.initials: F
authors.lastname: Clerget-Darpoux
mesh_terms: D030342:Genetic Diseases, Inborn; D020022:Genetic Predisposition to Disease; D015894:Genome, Human; D006801:Humans; D008957:Models, Genetic; D020412:Multifactorial Inheritance / Q000235:genetics*