title: Patterns of normal human brain plasticity after practice and their implications for neurorehabilitation.
abstract: OBJECTIVE
  To illustrate how our knowledge about normal patterns of experience-induced plasticity can provide insights into the mechanisms of neurorehabilitation; to provide an overview of the practice-effects literature in order to simplify and amalgamate a large number of heterogeneous findings and identify typical patterns of practice effects and their determining factors; and to concentrate on the impact of practice on higher cognitive functions, such as working memory, and present some preliminary but promising behavioral data that show how practice on a complex cognitive task can benefit cognitive functioning more generally.
  
  
  METHODS
  We performed a systematic search for peer-reviewed journal articles using computerized databases (PubMed, ISI Web of Science, PsycINFO).
  
  
  METHODS
  Neuroimaging studies using functional magnetic resonance imaging (fMRI) or positron-emission tomography (PET) to examine functional activation changes as a result of practice on sensory, motor, or cognitive tasks in normal (healthy) populations were included in the review. Further studies were identified that examined the effects of rehabilitative training on functional activations in clinical populations using fMRI or PET.
  
  
  METHODS
  Important characteristics of the selected studies were summarized in a systematic manner so to enable the extraction of specific factors impacting on the pattern of practice effects observed.
  
  
  RESULTS
  We identified a number of factors that impact on the patterns of practice effects observed and discuss how the insights gained from the study of healthy populations can by applied to rehabilitation of cognitive deficits in clinical populations.
  
  
  CONCLUSIONS
  Progress in our understanding of neurorehabilitative plasticity will be enabled by neuroimaging examinations of cognitive rehabilitation training grounded in a knowledge of normal (healthy) patterns of brain activation and practice-induced plasticity.
authors.affiliation: School of Psychology and Trinity College Institute of Neuroscience, Trinity College, Dublin, Ireland.
authors.forename: Clare
authors.initials: C
authors.lastname: Kelly
authors.forename: John J
authors.initials: JJ
authors.lastname: Foxe
authors.forename: Hugh
authors.initials: H
authors.lastname: Garavan
mesh_terms: D001921:Brain / Q000502:physiology*; D001927:Brain Diseases / Q000473:pathology / Q000503:physiopathology / Q000534:rehabilitation*; D003071:Cognition / Q000502:physiology; D006801:Humans; D008279:Magnetic Resonance Imaging; D009473:Neuronal Plasticity / Q000502:physiology*; D049268:Positron-Emission Tomography; D011214:Practice, Psychological; D020127:Recovery of Function / Q000502:physiology