Building addressable libraries: The use of a mass spectrometry cleavable linker for monitoring reactions on a microelectrode array.
Time-of-flight secondary ion mass spectrometry (TOF SIMS) has been used in conjunction with a mass spectrometry cleavable linker to determine the percent conversion of reactions that were conducted site-selectively on an addressable microelectrode array. When combined with fluorescence techniques for analysis of the reactions, the TOF SIMS experiment provides a means for optimization of both reaction confinement and reaction efficiency on the microelectrode arrays.
Chen
Ceng
C
Department of Chemistry, Washington University, St. Louis, Missouri 63130, USA.
Nagy
Gabriella
G
Walker
Amy V
AV
Maurer
Karl
K
McShea
Andy
A
Moeller
Kevin D
KD
D002138:Calibration; D003432:Cross-Linking Reagents / Q000737:chemistry*; D016208:Databases, Factual; D004566:Electrodes; D013058:Mass Spectrometry / Q000379:methods*; D046228:Microarray Analysis / Q000379:methods*; D015394:Molecular Structure; D010084:Oxidation-Reduction
D003432:Cross-Linking Reagents