title: Remission of IgA nephropathy after allogeneic peripheral blood stem cell transplantation followed by immunosuppression for acute lymphocytic leukemia.
abstract: We report a case with immunoglobulin A (IgA) nephropathy, showing IgA deposition which disappeared after peripheral blood stem cell transplantation (PBSCT) for acute lymphocytic leukemia (ALL). In 1996, a 28-year-old man was diagnosed with IgA nephropathy by renal biopsy. Steroid therapy improved proteinuria from 3 g/day to 1 g/day. In 2003, he received PBSCT following the initial therapy for ALL. After complete remission, urinary protein and hematuria remained at between (-) and (+/-). In 2004, the second renal biopsy specimen revealed no deposit of IgA or C3. These findings suggested that immune reconstruction with PBSCT following immunosuppression therapy was of benefit to IgA nephropathy.
authors.affiliation: Department of Internal Medicine, Toyama Prefectural Central Hospital, Toyama, Japan.
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Iwata
authors.forename: Takashi
authors.initials: T
authors.lastname: Wada
authors.forename: Akio
authors.initials: A
authors.lastname: Uchiyama
authors.forename: Atsuo
authors.initials: A
authors.lastname: Miwa
authors.forename: Izaya
authors.initials: I
authors.lastname: Nakaya
authors.forename: Tadashi
authors.initials: T
authors.lastname: Tohyama
authors.forename: Yuhji
authors.initials: Y
authors.lastname: Yamada
authors.forename: Toshiro
authors.initials: T
authors.lastname: Kurokawa
authors.forename: Takashi
authors.initials: T
authors.lastname: Yoshida
authors.forename: Satoshi
authors.initials: S
authors.lastname: Ohta
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Yokoyama
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Iida
mesh_terms: D000328:Adult; D005922:Glomerulonephritis, IGA / Q000150:complications* / Q000473:pathology*; D006801:Humans; D007165:Immunosuppression Therapy; D007668:Kidney / Q000473:pathology; D008297:Male; D036102:Peripheral Blood Stem Cell Transplantation; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000601:surgery*; D012074:Remission Induction