title: Synthesis of carbocyclic analogues of 4'-ethynyl- and 4'-cyano-d4T.
abstract: Synthesis of carbocyclic analogues of 4'-ethynyl and cyano-d4T (4 and 5) was investigated. The ethynyl or cyano group was constructed by conversion of the ester function of key intermediate 13. The carbocyclic unit 12 was prepared from readily available beta-keto ester 6.
authors.affiliation: School of Pharmaceutical Sciences, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Kumamoto
authors.forename: Keisuke
authors.initials: K
authors.lastname: Kato
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Haraguchi
authors.forename: Hiromichi
authors.initials: H
authors.lastname: Tanaka
authors.forename: Takao
authors.initials: T
authors.lastname: Nitanda
authors.forename: Masanori
authors.initials: M
authors.lastname: Baba
authors.forename: Ginger E
authors.initials: GE
authors.lastname: Dutschman
authors.forename: Yung-Chi
authors.initials: YC
authors.lastname: Cheng
mesh_terms: D000146:Acids, Carbocyclic / Q000737:chemistry*; D019380:Anti-HIV Agents / Q000138:chemical synthesis* / Q000737:chemistry; D018119:Stavudine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry
chemical_list: C521141:4'-cyano-2',3'-didehydro-2',3'-dideoxythymidine; C505960:4'-ethynylstavudine; D000146:Acids, Carbocyclic; D019380:Anti-HIV Agents; D018119:Stavudine