title: [Effects of risperidone on polysomnography in patients with first-episode schizophrenia].
abstract: OBJECTIVE
  To investigate the effects of risperidone on the polysomnography (PSG) in the patients with first-episode schizophrenia.
  
  
  METHODS
  Twenty-five patients with first-episode schizophrenia, 13 males and 12 females, aged 29 +/- 8, underwent polysomnographic recording for 4 consecutive nights, the first night being used for acclimatization, and on the 3 rd and 4 th nights risperidone in the dose of 1.2 mg was administered before going to bed. Forty-four healthy persons, 23 males and 21 females, aged 28 +/- 8, underwent polysomnographic recording for 2 consecutive nights, the first night being used for acclimatization.
  
  
  RESULTS
  The baseline PSG recording showed that in comparison with the normal control group the total sleep time of the schizophrenia patients was shorter (378 min +/- 30 min vs 462 min +/- 21 min), sleep latency was longer (30 min +/- 14 min vs 18 min +/- 8 min), rapid eye movement (REM) sleep latency was shorter (59 min +/- 20 min vs 88 min +/- 10 min), REM sleep time was shorter (61 min +/- 17 min vs 84 min +/- 12 min), awakening time was longer (34 min +/- 17 min vs 15 min +/- 5 min), stage 1 (S1) time was longer (22% +/- 10% vs 9.0% +/- 1.7%), S3 time and S4 time were shorter, and the sleep efficacy was lower (86% +/- 10%) (P < 0.05 approximately P < 0.01); however, there was no significant difference in the S2 time between these 2 groups (54% +/- 16% vs 56% +/- 4%, P > 0.05). In the schizophrenia group, in comparison with the baseline levels in the third and fourth nights the total sleep times were significantly increased (406 min +/- 34 min and 428 min +/- 31 min respectively), the awakening times were significantly decreased (23 min +/- 15 min and 19 min +/- 8 min respectively), and S1 times were significantly decreased (14 min +/- 9 min and 10 min +/- 9 min respectively), with such changes time-dependently; and in the 4 th night the REM sleep time was significantly increased (87 min +/- 20 min) and the sleep efficacy was significantly improved (93% +/- 12%) (P < 0.05 approximately P < 0.01), however, there were no significant differences in the sleep latency and slow wave sleep (both P > 0.05).
  
  
  CONCLUSIONS
  Risperidone significantly improves the quality of sleep.
authors.affiliation: Department of Electrophysiology, Shanghai Institute of Mental Health, Shanghai, China.
authors.forename: Xing-shi
authors.initials: XS
authors.lastname: Chen
authors.forename: Ming-dao
authors.initials: MD
authors.lastname: Zhang
authors.forename: Fei-ying
authors.initials: FY
authors.lastname: Lou
authors.forename: Hong-xing
authors.initials: HX
authors.lastname: Wang
authors.forename: Ji-jun
authors.initials: JJ
authors.lastname: Wang
authors.forename: Jian-hua
authors.initials: JH
authors.lastname: Liang
authors.forename: Chong
authors.initials: C
authors.lastname: Chen
authors.forename: Xin-wei
authors.initials: XW
authors.lastname: Chen
authors.forename: Li
authors.initials: L
authors.lastname: Liu
authors.forename: Cun-you
authors.initials: CY
authors.lastname: Gao
authors.forename: Ping
authors.initials: P
authors.lastname: Liu
authors.forename: Xiao-wei
authors.initials: XW
authors.lastname: Liu
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000494:pharmacology / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017286:Polysomnography / Q000187:drug effects*; D018967:Risperidone / Q000494:pharmacology / Q000627:therapeutic use*; D012559:Schizophrenia / Q000188:drug therapy* / Q000503:physiopathology; D012890:Sleep / Q000187:drug effects; D013997:Time Factors
chemical_list: D014150:Antipsychotic Agents; D018967:Risperidone