title: Psychiatric symptoms and cognitive dysfunction caused by Epstein-Barr virus-induced encephalitis.
abstract: Epstein-Barr virus (EBV) encephalitis is rare and shows a wide range of clinical manifestations. We report an immunocompromised patient with EBV encephalitis diagnosed by EBV-specific PCR and antibody testing in the cerebrospinal fluid who presented with psychiatric symptoms and cognitive dysfunction in the absence of any neurological impairments or infectious signs. Clinical recovery and clearance of cerebrospinal fluid EBV DNA appeared following ganciclovir treatment within 6 weeks.
authors.affiliation: Department of Psychiatry and Psychotherapy, Charite University Medicine Berlin, Campus Charite Mitte, Schumannstr. 20/21, 10117 Berlin, Germany. joachim.behr@charite.de
authors.forename: Joachim
authors.initials: J
authors.lastname: Behr
authors.forename: Martin
authors.initials: M
authors.lastname: Schaefer
authors.forename: Eckhard
authors.initials: E
authors.lastname: Littmann
authors.forename: Randolf
authors.initials: R
authors.lastname: Klingebiel
authors.forename: Andreas
authors.initials: A
authors.lastname: Heinz
mesh_terms: D000998:Antiviral Agents / Q000008:administration & dosage / Q000627:therapeutic use; D016026:Bone Marrow Transplantation; D001921:Brain / Q000473:pathology; D003072:Cognition Disorders / Q000188:drug therapy / Q000209:etiology* / Q000523:psychology*; D004247:DNA / Q000134:cerebrospinal fluid; D018792:Encephalitis, Viral / Q000150:complications* / Q000188:drug therapy / Q000523:psychology*; D020031:Epstein-Barr Virus Infections / Q000150:complications* / Q000188:drug therapy / Q000523:psychology*; D005500:Follow-Up Studies; D015774:Ganciclovir / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D007263:Infusions, Parenteral / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction / Q000379:methods; D035583:Rare Diseases; D016896:Treatment Outcome
chemical_list: D000998:Antiviral Agents; D004247:DNA; D015774:Ganciclovir