Evaluation of immunogenicity and tolerability of a live attenuated hepatitis a vaccine in Indian children.
An open non comparative study of a live attenuated H2 strain Hepatitis A vaccine of Chinese origin was carried out in 143 healthy Indian children aged 1 to 12 years (mean age 4.87 2.76 years; 88 boys, 55 girls). At baseline, all were negative for IgG HAV antibodies and had normal hematological and biochemical indices. Two months after a single dose of the vaccine (given subcutaneously), 137 children (i.e. 95.8 %) developed protective antibodies of IgG > 20 mIU / mL. The hematological and biochemical parameters remained within normal limits. There were no adverse events in any except mild fever in one child. In conclusion, live attenuated H2 strain Hepatitis A vaccine in a single dose was found to be immunogenic and safe in Indian children.
Bhave
Sheila
S
Department of Pediatrics, KEM Hospital, Pune 411 011, India. kemhrc@vsnl.com
Bavdekar
Ashish
A
Madan
Zinobia
Z
Jha
Rasendrakumar
R
Bhure
Shraddha
S
Chaudhari
Jayant
J
Pandit
Anand
A
D002648:Child; D002675:Child, Preschool; D005260:Female; D022362:Hepatitis A Vaccines / Q000009:adverse effects / Q000276:immunology*; D018937:Hepatitis C Antibodies / Q000097:blood; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007194:India; D007223:Infant; D008297:Male; D012449:Safety; D014613:Vaccines, Attenuated
D022362:Hepatitis A Vaccines; D018937:Hepatitis C Antibodies; D007074:Immunoglobulin G; D014613:Vaccines, Attenuated