title: Quality of life after contralateral prophylactic mastectomy in newly diagnosed high-risk breast cancer patients who underwent BRCA1/2 gene testing.
abstract: OBJECTIVE
  Recent studies indicate that high-risk breast cancer patients (ie, women who carry mutations in BRCA1/2 genes) who opt for contralateral prophylactic mastectomy (CPM) have a substantially reduced risk of developing contralateral breast cancer. However, the immediate and long-term impact of this decision on women's quality of life and psychosocial functioning is largely unknown. In this study, we compared the impact of BRCA1/2 genetic test result and CPM on these outcomes among newly diagnosed breast cancer patients who opted for CPM at the time of their definitive surgical treatment versus patients who did not.
  
  
  METHODS
  Participants were 149 high-risk women who underwent genetic counseling and testing for alterations in the BRCA1/2 genes. We measured self-reported quality of life, cancer-specific distress, and genetic testing-specific distress using standardized instruments before receipt of genetic test results and again 1 and 12 months later.
  
  
  RESULTS
  Compared with patients who chose breast conservation or unilateral mastectomy, those who chose mastectomy of the affected breast and CPM of the unaffected breast did not report diminished quality of life or elevated distress.
  
  
  CONCLUSIONS
  With respect to quality of life and distress, patients who choose CPM fare as well as those who do not in the first year after surgery.
authors.affiliation: Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC 20007-2401, USA.
authors.forename: Kenneth P
authors.initials: KP
authors.lastname: Tercyak
authors.forename: Beth N
authors.initials: BN
authors.lastname: Peshkin
authors.forename: Barbara M
authors.initials: BM
authors.lastname: Brogan
authors.forename: Tiffani
authors.initials: T
authors.lastname: DeMarco
authors.forename: Marie F
authors.initials: MF
authors.lastname: Pennanen
authors.forename: Shawna C
authors.initials: SC
authors.lastname: Willey
authors.forename: Colette M
authors.initials: CM
authors.lastname: Magnant
authors.forename: Sarah
authors.initials: S
authors.lastname: Rogers
authors.forename: Claudine
authors.initials: C
authors.lastname: Isaacs
authors.forename: Marc D
authors.initials: MD
authors.lastname: Schwartz
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000235:genetics* / Q000517:prevention & control* / Q000523:psychology; D005260:Female; D019398:Genes, BRCA1; D024522:Genes, BRCA2; D005817:Genetic Counseling; D020022:Genetic Predisposition to Disease; D006801:Humans; D008408:Mastectomy / Q000523:psychology*; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000517:prevention & control*; D011788:Quality of Life; D013315:Stress, Psychological