title: Autoantibodies to the inhibitor of apoptosis protein survivin in patients with brain tumors.
abstract: Survivin is a member of the inhibitor of apoptosis protein (IAP) family and is frequently expressed in cancers, including meningiomas and gliomas. Survivin may be associated with tumor progression and poor prognosis of patients with brain tumors. Using ELISA and immunoblot analysis we asked whether survivin is capable of eliciting a humoral immune response in patients with meningiomas and gliomas. Survivin-specific antibodies were detected in 5 of 42 (11.9%) patients with meningiomas and 3 of 35 (8.6%) patients with malignant gliomas of the WHO grades 3 and 4, but not in healthy controls. Tumors of patients with detectable anti-survivin antibodies demonstrated survivin expression in at least 20% of the tumor cells as assessed by immunohistochemistry. We conclude that patients with meningiomas and malignant gliomas can mount a high-titer IgG immune response against the 'universal' tumor-associated antigen survivin. Anti-survivin antibodies may represent attractive tools for diagnosis and follow-up of brain tumors.
authors.affiliation: Molecular Neurooncology Laboratory, Department of Neurosurgery, Martin Luther University Halle-Wittenberg, D-06097 Halle, Germany. ariane.soeling@medizin.uni-halle.de
authors.forename: Ariane
authors.initials: A
authors.lastname: Söling
authors.forename: Eva-Maria
authors.initials: EM
authors.lastname: Plugge
authors.forename: Marc
authors.initials: M
authors.lastname: Schmitz
authors.forename: Bernd
authors.initials: B
authors.lastname: Weigle
authors.forename: Roland
authors.initials: R
authors.lastname: Jacob
authors.forename: Jörg
authors.initials: J
authors.lastname: Illert
authors.forename: Hans-Jürgen
authors.initials: HJ
authors.lastname: Holzhausen
authors.forename: Nikolai G
authors.initials: NG
authors.lastname: Rainov
mesh_terms: D000328:Adult; D000368:Aged; D017209:Apoptosis / Q000276:immunology; D001323:Autoantibodies / Q000097:blood*; D001932:Brain Neoplasms / Q000276:immunology* / Q000473:pathology; D005910:Glioma / Q000276:immunology / Q000473:pathology; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D051034:Inhibitor of Apoptosis Proteins; D008579:Meningioma / Q000276:immunology / Q000473:pathology; D008869:Microtubule-Associated Proteins / Q000235:genetics / Q000276:immunology*; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000235:genetics / Q000276:immunology*; D009367:Neoplasm Staging; D011994:Recombinant Proteins / Q000276:immunology; D012016:Reference Values; D000077022:Survivin
chemical_list: D001323:Autoantibodies; C107489:BIRC5 protein, human; D007074:Immunoglobulin G; D051034:Inhibitor of Apoptosis Proteins; D008869:Microtubule-Associated Proteins; D009363:Neoplasm Proteins; D011994:Recombinant Proteins; D000077022:Survivin