Does povidone-iodine liposome hydrogel influence postoperative intra-abdominal adhesions?
OBJECTIVE
To evaluate the effect of PVP-I liposome hydrogel on intraperitoneal postoperative adhesions.


METHODS
Thirty Wistar -Albino male rats were randomly divided into three groups. After midline laparotomy, a 1 cm(2) area of the caecum was abraded with a sterile gauze until subserosal haemorrhage had developed. A 1 x 1 cm patch of peritoneum located opposite of caecal abrasion was completely dissected. In group 1 (control group, C) adhesion induction was performed and nothing was applied to the wounds. In group 2 and 3, PVP-I solution (3%) (group 2, PI) and PVP-I liposome hydrogel (group 3, PIL) were applied to the caecal abrasion areas and peritoneal defects. Adhesions were classified according to a classification system based on the evaluation of the appearance, extent and strength of the adhesions on postoperative 2lst day.


RESULTS
There was no significant difference of the adhesion scores between the groups (U1 = 45, p > 0.05 ; U2 = 48, p > 0.05 ; U3 = 47.5, p > 0.05).


CONCLUSIONS
We found that PVP liposome hydrogel did not influence postoperative intraabdominal adhesions and should be further explored for its potential use in various intraabdominal procedures.
Adibelli
M A
MA
Department of General Surgery, Ankara Training and Research Hospital, Ankara, Turkey.
Ozcan
A H
AH
Kismet
K
K
Erel
S
S
Kilicoglu
B
B
Gollu
A
A
Akkus
M A
MA
D000818:Animals; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000494:pharmacology*; D007410:Intestinal Diseases / Q000473:pathology*; D008081:Liposomes; D008297:Male; D010532:Peritoneal Diseases / Q000473:pathology*; D011183:Postoperative Complications; D011206:Povidone-Iodine / Q000494:pharmacology*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D000267:Tissue Adhesions; D014945:Wound Healing / Q000187:drug effects
D008081:Liposomes; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D011206:Povidone-Iodine