The road from teratocarcinoma to human embryonic stem cells.
In this article, a brief review of the research that began with the study of murine teratomas of the testis and ultimately led to the culture of human embryonic stem cells is discussed. Most of the space will be devoted to the studies in which the author personally took part, and the discussion will also touch upon some of the crucial experiments important for the understanding of this entire research effort.
Damjanov
Ivan
I
Department of Pathology, The University of Kansas School of Medicine, Kansas City 66160-7410, USA. idamjano@kumc.edu
D000818:Animals; D035843:Biomedical Research / Q000639:trends; D018929:Cell Culture Techniques / Q000379:methods; D053595:Embryonic Stem Cells / Q000378:metabolism* / Q000648:ultrastructure; D006801:Humans; D008297:Male; D051379:Mice; D018243:Teratocarcinoma / Q000378:metabolism* / Q000648:ultrastructure; D013724:Teratoma / Q000378:metabolism* / Q000648:ultrastructure; D013736:Testicular Neoplasms / Q000378:metabolism* / Q000648:ultrastructure; D014407:Tumor Cells, Cultured