[Experimental study of the efficacy of apovincaminic acid derivative on the model of reperfusive cerebral damage].
Neuroprotector properties of a new apovincaminic acid derivative (LHT 2 - 02) were studied on a model of acute brain ischemia in cats. LHT 2 - 02 has proved to be more effective than the reference drugs vinpocetin and glycine in preventing the reperfusive damage, which was manifested by decreased postishemic hyperglycemia and suppressed postishemic metabolic lactate acidosis.
Makarova
L M
LM
Prikhod'ko
M A
MA
Pogorelyĭ
V E
VE
Skachilova
S Ia
SIa
Sernov
L H
LH
Ermakova
G A
GA
D000140:Acidosis, Lactic / Q000188:drug therapy; D000818:Animals; D002545:Brain Ischemia / Q000517:prevention & control*; D002415:Cats; D005998:Glycine / Q000627:therapeutic use; D006943:Hyperglycemia / Q000188:drug therapy; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D015427:Reperfusion Injury / Q000517:prevention & control*; D014748:Vinca Alkaloids / Q000737:chemistry* / Q000627:therapeutic use*
C516363:LHT 2 - 02; D018696:Neuroprotective Agents; D014748:Vinca Alkaloids; C032858:apovincaminic acid; C013983:vinpocetine; D005998:Glycine