Costimulation tunes tumor-specific activation of redirected T cells in adoptive immunotherapy.
Redirecting T cell effector functions towards pre-defined target cells represents an attractive concept in the adoptive immunotherapy of malignant diseases. Our understanding of the mechanisms of T cell activation and costimulation as well as the design of recombinant T cell receptors have made major progress in the last years. Translating recent concepts of T cell stimulation into recombinant protein design provides the basis to engineer T cells with both pre-defined specificity and costimulatory capacity in order to enhance anti-tumor immunity and to break tolerance. Dual signaling immunoreceptors providing the CD3zeta signal simultaneously with an appropriate costimulatory signal moreover allows to modulate the quality of the anti-tumor T cell response in a predicted fashion.
Hombach
Andreas
A
Tumorgenetik, Klinik I für Innere Medizin, and Zentrum für Molekulare Medizin Köln, Klinikum der Universität zu Köln, Köln, Germany.
Abken
Hinrich
H
D000818:Animals; D006801:Humans; D007108:Immune Tolerance; D016219:Immunotherapy, Adoptive; D008213:Lymphocyte Activation / Q000276:immunology*; D009369:Neoplasms / Q000276:immunology; D011948:Receptors, Antigen, T-Cell / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*; D019139:Tumor Escape
D011948:Receptors, Antigen, T-Cell