[Endothelial dysfunction in peritoneal dialysis patients and its relationship to nutrition].
Endothelial dysfunction (ED) in peritoneal dialysis patients plays pivotal role in progression of atherosclerosis and hemostasis disturbances. Malnutrition is one of the most important complication of PD. Both ED and malnutrition cause higher rate of cardiovascular events in these patients. 32 PD patients were analyzed. Endothelial function was assessed by measurements of serum level of vWF:Ag; t-Pa:Ag; TM:Ag. Nutritional status assessment included: body mass index-BMI, MAMC measurements; and serum albumin, total protein, prealbumin, transferrin, cholesterol, insulin, insulin like growth factor-1 (IGF-1). There were higher levels of vWF:Ag but lower of t-PA:Ag and TM:Ag after 12 month of observation. Serum levels of prealbumin, insulin, cholesterol were stable, but there were lower levels of albumin, IGF-1, and higher of transferrin at the end of the follow up. There were no differences in anthropometric indices during the follow up. We found statistically significant linear correlations: t-Pa:Ag vs prealbumin; t-Pa:Ag vs cholesterol; TM:Ag vs albumin. In the course of 12 months observation of peritoneal dialysis patients we found deterioration of endothelial function, expressed by evaluated endothelial antigens. Some correlations found in our study might express close relationship between endothelial function markers and nutritional status.
Donderski
Rafał
R
Uniwersytet Mikołaja Kopernika w Toruniu, Collegium Medicum w Bydgoszczy. kiknefichw@cm.umk.pl
Grajewska
Magdalena
M
Chmielewski
Michał
M
Odrowaz-Sypniewska
Grazyna
G
Kotschy
Maria
M
Manitius
Jacek
J
Rutkowski
Bolesław
B
D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000378:metabolism; D042783:Endothelial Cells / Q000378:metabolism*; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000503:physiopathology / Q000628:therapy*; D008297:Male; D044342:Malnutrition / Q000209:etiology* / Q000503:physiopathology*; D008875:Middle Aged; D010531:Peritoneal Dialysis, Continuous Ambulatory / Q000009:adverse effects* / Q000379:methods; D011502:Protein-Energy Malnutrition / Q000097:blood; D012709:Serum Albumin / Q000032:analysis; D014841:von Willebrand Factor / Q000032:analysis
D015415:Biomarkers; D012709:Serum Albumin; D014841:von Willebrand Factor