The correlation between levels of IL-7Ralpha expression and responsiveness to IL-7 is lost in CD4 lymphocytes from HIV-infected patients.
Measurements of Bcl-2 and CD25 expression suggested that IL-7R function is modified in CD4 lymphocytes of untreated viraemic patients. The extent of IL-7R function restoration post-HAART was analysed. A positive linear relationship was demonstrated between IL-7Ralpha expression and the magnitude of IL-7-induced responses in healthy individuals, whereas this relationship is lost in HIV-infected patients, suggesting that viraemic patients suffer a receptor signaling transduction defect in IL-7R function. IL-7 responsiveness is only partly restored by HAART.
Colle
Jean-Hervé
JH
Unité Immunogénétique Cellulaire, Département Infection et Epidémiologie, Institut Pasteur, Paris, France.
Moreau
Jean-Louis
JL
Fontanet
Arnaud
A
Lambotte
Olivier
O
Delfraissy
Jean-François
JF
Thèze
Jacques
J
D019380:Anti-HIV Agents / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D016022:Case-Control Studies; D015658:HIV Infections / Q000188:drug therapy / Q000276:immunology*; D006801:Humans; D053645:Interleukin-2 Receptor alpha Subunit / Q000276:immunology; D015851:Interleukin-7 / Q000276:immunology*; D053699:Interleukin-7 Receptor alpha Subunit / Q000276:immunology; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000276:immunology; D020395:Receptors, Interleukin-7 / Q000276:immunology*; D019562:Viral Load
D019380:Anti-HIV Agents; D053645:Interleukin-2 Receptor alpha Subunit; D015851:Interleukin-7; D053699:Interleukin-7 Receptor alpha Subunit; D019253:Proto-Oncogene Proteins c-bcl-2; D020395:Receptors, Interleukin-7; C415350:interleukin-7 receptor, alpha chain