Molecular design of alkylating pyrrole-imidazole polyamides with indole linker.
A series of novel DNA alkylating polyamide possessing indole linker was synthesized. The reactivities and specificities of these polyamides with double strand DNA were investigated by using high-resolution gel electrophoresis. The results revealed that the indole linker linked Py-Im polyamides have the high alkylating activities and sequence specificities comparable to vinyl linker linked Py-Im polyamides.
Sasaki
Shunta
S
School of Biomedical Science, Tokyo Medical and Dental University, 2-3-10 Kanda-Surugadai, Chiyoda-ku, Tokyo 101-0062, Japan.
Narita
Akihiko
A
Bando
Toshikazu
T
Sugiyama
Hiroshi
H
D000478:Alkylation; D007093:Imidazoles / Q000737:chemistry*; D007211:Indoles / Q000737:chemistry*; D009757:Nylons / Q000737:chemistry*; D011758:Pyrroles / Q000737:chemistry*
D007093:Imidazoles; D007211:Indoles; D009757:Nylons; D011758:Pyrroles; C029899:imidazole; C030374:indole