title: N-terminal brain natriuretic propeptide levels correlate with procalcitonin and C-reactive protein levels in septic patients.
abstract: The aim of this study was to find the relationship between N-terminal brain natriuretic propeptide (NT-proBNP), procalcitonin (PCT) and C-reactive protein (CRP) plasma concentrations in septic patients. This was a prospective study, performed at Medical University Hospital No. 5 in łódź. Twenty patients with sepsis and severe sepsis were included in the study. N-terminal brain natriuretic propeptide, procalcitonin and C-reactive protein concentrations, and survival were evaluated. In the whole studied group (128 measurements), the mean NT-proBNP, procalcitonin and C-reactive protein concentrations were, respectively: 140.80+/-84.65 pg/ml, 22.32+/-97.41 ng/ml, 128.51+/-79.05 mg/l. The correlations for the NT-proBNP level and procalcitonin and C-reactive protein levels were 0.3273 (p<0.001) and 0.4134 (p<0.001), respectively. NT-proBNP levels correlate with PCT and CRP levels in septic patients. In the survivor subgroup, the mean NT-proBNP plasma concentrations were significantly lower than in the non-survivor subgroup.
authors.affiliation: Department of Anaesthesiology and Intensive Care Unit, Bolesław Szarecki University Hospital No. 5 in Łódź, Medical University of Łódź, Poland.
authors.forename: Mariusz
authors.initials: M
authors.lastname: Piechota
authors.forename: Maciej
authors.initials: M
authors.lastname: Banach
authors.forename: Robert
authors.initials: R
authors.lastname: Irzmański
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Misztal
authors.forename: Jacek
authors.initials: J
authors.lastname: Rysz
authors.forename: Marcin
authors.initials: M
authors.lastname: Barylski
authors.forename: Magdalena
authors.initials: M
authors.lastname: Piechota-Urbańska
authors.forename: Jan
authors.initials: J
authors.lastname: Kowalski
authors.forename: Lucjan
authors.initials: L
authors.lastname: Pawlicki
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002097:C-Reactive Protein / Q000032:analysis*; D002116:Calcitonin / Q000097:blood*; D015740:Calcitonin Gene-Related Peptide; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D011498:Protein Precursors / Q000097:blood*; D018805:Sepsis / Q000097:blood*
chemical_list: C000606589:CALCA protein, human; D011498:Protein Precursors; D020097:Natriuretic Peptide, Brain; D002116:Calcitonin; D002097:C-Reactive Protein; D015740:Calcitonin Gene-Related Peptide