title: Synthesis of a novel inhibitor against MRSA and VRE: preparation from zerumbone ring opening material showing histidine-kinase inhibition.
abstract: Zerumbone ring-opening derivative 2 inhibited autophosphorylation of the essential histidine protein kinase (HPK), YycG, existing in Bacillus subtilis constituting a two-component system (TCS). However, it did not inhibit drug-resistant bacterium such as MRSA and VRE. Tryptophan derivative 34 also could be regulated by a TCS system like 2. In addition, 34 showed good inhibition against MRSA and VRE.
authors.affiliation: Department of Advanced Bioscience, Graduate School of Agriculture, Kinki University, Nara 631-8505, Japan. kitayama@nara.kindai.ac.jp
authors.forename: Takashi
authors.initials: T
authors.lastname: Kitayama
authors.forename: Risa
authors.initials: R
authors.lastname: Iwabuchi
authors.forename: Shu
authors.initials: S
authors.lastname: Minagawa
authors.forename: Seiji
authors.initials: S
authors.lastname: Sawada
authors.forename: Ryo
authors.initials: R
authors.lastname: Okumura
authors.forename: Kazuki
authors.initials: K
authors.lastname: Hoshino
authors.forename: John
authors.initials: J
authors.lastname: Cappiello
authors.forename: Ryutaro
authors.initials: R
authors.lastname: Utsumi
mesh_terms: D001412:Bacillus subtilis / Q000201:enzymology; D013293:Enterococcus faecalis / Q000187:drug effects*; D000071677:Histidine Kinase; D016106:Methicillin Resistance / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D010766:Phosphorylation; D011494:Protein Kinases / Q000187:drug effects*; D012717:Sesquiterpenes / Q000138:chemical synthesis* / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000201:enzymology; D014364:Tryptophan / Q000031:analogs & derivatives / Q000494:pharmacology
chemical_list: D012717:Sesquiterpenes; C403304:zerumbone; D014364:Tryptophan; D011494:Protein Kinases; D000071677:Histidine Kinase