title: CIAT with simultaneous epimerization at two stereocenters. Synthesis of substituted beta-methyl-alpha-homophenylalanines.
abstract: Diastereoselective aza-Michael additions of phenylethylamine to 3-aroylbutenoic acids are reported. During these processes, efficient control over two new stereogenic centers on the Michael acceptor has been possible via crystallization-induced asymmetric transformation (CIAT). As an application, a convenient two-step synthesis of anti-beta-methylhomophenylalanines is also described.
authors.affiliation: Department of organic chemistry, Slovak University of Technology, Radlinského 9, SK-81237, Bratislava, Slovakia. dusan.berkes@stuba.sk
authors.forename: Dusan
authors.initials: D
authors.lastname: Berkes
authors.forename: Pavol
authors.initials: P
authors.lastname: Jakubec
authors.forename: Dagmar
authors.initials: D
authors.lastname: Winklerová
authors.forename: Frantisek
authors.initials: F
authors.lastname: Povazanec
authors.forename: Adam
authors.initials: A
authors.lastname: Daich