Three-dimensional structure of the ternary complex of yeast tyrosyl-tRNA synthetase.
The archaeal/eukaryotic tyrosyl tRNA synthetase (TyrRS)-tRNA(Tyr) pairs do not cross-react with their prokaryotic counterparts. Recently, crystal structure analyses of prokaryotic and archaeal TyrRSs complexed with their cognate tRNA(Tyr) have been reported, however, no structure is available for eukaryotic TyrRS complexed with its cognate tRNA(Tyr). Here we report the crystal structure of yeast Tyrosyl-tRNA synthetase (yTyrRS) complexed with its cognate tRNA(Tyr) and Tyr-AMP analog.
Tsunoda
Masaru
M
School of Pharmaceutical Sciences, Showa University, Tokyo 142-8555, Japan.
Kusakabe
Yoshio
Y
Tanaka
Nobutada
N
Ohno
Satoshi
S
Nakamura
Masashi
M
Senda
Toshiya
T
Sekine
Mitsuo
M
Yokogawa
Takashi
T
Nishikawa
Kazuya
K
Nakamura
Kazuo T
KT
D003460:Crystallization; D018360:Crystallography, X-Ray; D012441:Saccharomyces cerevisiae / Q000201:enzymology*; D014448:Tyrosine-tRNA Ligase / Q000737:chemistry*
D014448:Tyrosine-tRNA Ligase