Efficiency of cardioplegic solutions containing L-arginine and L-aspartic acid.
In experiments on rats we studied the effects of cardioplegic solutions with L-aspartic acid or L-arginine on functional recovery and metabolism of isolated working heart after 40-min normothermal global ischemia and 30-min reperfusion. After reperfusion of the hearts preventively protected with cardioplegic solution containing L-aspartic acid or L-arginine, coronary flow decreased in comparison with the initial values. As a component of cardioplegic solution, L-arginine was less efficient in recovery of contractility and cardiac output of the hearts in comparison with L-aspartic acid. In hearts protected with L-aspartic acid, the postischemic levels of ATP and phosphocreatine were significantly higher, and the level of lactate was significantly lower than in hearts protected with L-arginine. In comparison with L-arginine, L-aspartic acid is a more efficient component of cardioplegic solution in protection of the heart from metabolic and functional damages caused by global ischemia and reperfusion.
Pisarenko
O I
OI
Institute of Experimental Cardiology, Russian Cardiology Research-and-Production Complex, Moscow. olpi@cardio.ru
Shul'zhenko
V S
VS
Studneva
I M
IM
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D001120:Arginine / Q000378:metabolism / Q000494:pharmacology*; D001224:Aspartic Acid / Q000494:pharmacology*; D001794:Blood Pressure; D002314:Cardioplegic Solutions / Q000378:metabolism* / Q000494:pharmacology; D002384:Catalysis; D007511:Ischemia / Q000473:pathology; D007773:Lactates / Q000378:metabolism; D010725:Phosphocreatine / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury; D013997:Time Factors
D002314:Cardioplegic Solutions; D007773:Lactates; D010725:Phosphocreatine; D001224:Aspartic Acid; D000255:Adenosine Triphosphate; D001120:Arginine