title: Osteonecrosis of the jaw and bisphosphonates--putting the risk in perspective.
abstract: Osteonecrosis of the jaw is a poorly understood condition that has recently been associated with the use of potent bisphosphonate treatment. The prevalence appears to be approximately 1-10% in patients with malignancy treated with very high doses of intravenous bisphosphonates. In Paget's disease and osteoporosis, where the doses of bisphosphonate used are an order of magnitude lower than the oncology dose, the prevalence appears to be much lower--probably less than 1 in 60,000. The aim of this article is to put the risks of osteonecrosis of the jaw into context with the benefits of bisphosphonate treatment in these clinical scenarios.
authors.affiliation: Department of Medicine, University of Auckland. m.bolland@auckland.ac.nz
authors.forename: Mark
authors.initials: M
authors.lastname: Bolland
authors.forename: David
authors.initials: D
authors.lastname: Hay
authors.forename: Andrew
authors.initials: A
authors.lastname: Grey
authors.forename: Ian
authors.initials: I
authors.lastname: Reid
authors.forename: Tim
authors.initials: T
authors.lastname: Cundy
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003729:Dental Care; D004164:Diphosphonates / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007571:Jaw Diseases / Q000139:chemically induced* / Q000503:physiopathology / Q000517:prevention & control; D008297:Male; D009369:Neoplasms / Q000188:drug therapy; D010001:Osteitis Deformans / Q000188:drug therapy; D010020:Osteonecrosis / Q000139:chemically induced* / Q000503:physiopathology / Q000517:prevention & control; D015663:Osteoporosis, Postmenopausal / Q000517:prevention & control; D018570:Risk Assessment
chemical_list: D004164:Diphosphonates