[Clinical analysis of yuziwan in the treatment of 30 sterile men with abnormal protamine].
OBJECTIVE
To study the clinical application and effects of Yuziwan in the treatment of male sterility patient with abnormal protamine.


METHODS
The changes of protamine, semen and sex hormones of 30 male sterility patients treated by Yuziwan were observed before and after the treatment.


RESULTS
After a 3-month course of treatment, 9 cases were cured, 15 obviously improved and 6 failed to respond. The ratio of histone to protamine was decreased from (1.34 +/- 0.52) before the treatment to (0.72 +/- 0.32) after it, with significant difference (P < 0.01), the semen quality obviously improved (P < 0.05), and the LH and T levels markedly raised (P < 0.01). Yuziwan evidently improved the abnormal protamine, sperm quality and endocrine function of the sterility patients.


CONCLUSIONS
Yuziwan has good curative effect on male sterility.
Wang
Xu-chu
XC
Center of Reproductive Medicine, Cangzhou Hospital of Integrated TMC and Western Medicine, Cangzhou, Hebei 061001, China. yixiangzhai@sina.com
Li
Hai-song
HS
Pan
Tian-ming
TM
D000328:Adult; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D006657:Histones / Q000378:metabolism; D006801:Humans; D007248:Infertility, Male / Q000188:drug therapy* / Q000378:metabolism; D008297:Male; D008517:Phytotherapy; D011479:Protamines / Q000378:metabolism
D004365:Drugs, Chinese Herbal; D006657:Histones; D011479:Protamines