title: Health-related quality of life in French people living with HIV in 2003: results from the national ANRS-EN12-VESPA Study.
abstract: OBJECTIVE
  Since the advent of HAART, the assessment of health-related quality of life (HRQL) has become a major concern in the therapeutic follow-up of people living with HIV.
  
  
  METHODS
  HRQL was evaluated for 2235 participants in the ANRS-EN12-VESPA Study. These participants completed the Medical Outcome Study 36-Item Short Form Health Survey (MOS SF-36) questionnaire. Anxiety and depression were assessed using the Hospital Anxiety and Depression (HAD) scale. Individuals were considered to have an 'acceptable' physical (and mental) HRQL if their MOS SF-36 scores were greater than the 25 percentile of the corresponding age-sex-specific distribution of scores in the French general population.
  
  
  METHODS
  Logistic regression models were used to identify factors associated with an 'acceptable' physical and mental HRQL among demographic, psychosocial and clinical characteristics. Potential selection bias caused by non-random missing responses to the MOS SF-36 questionnaire was statistically tested.
  
  
  RESULTS
  Physical and mental HRQL were 'acceptable' in 1176 (53%) and 1152 (51%) individuals, respectively. After adjusting for sociodemographic factors, HIV clinical status and hepatitis C co-infection, high HAD scores and the consumption of anxiolytic, antidepressant and hypnotic drugs were found to be negatively associated with normal physical and mental HRQL.
  
  
  CONCLUSIONS
  The role of disclosure and discrimination is determinant in HRQL, and the various cultural and psychological dimensions require further research. The presence of other infections or co-morbidities requires a comprehensive care system including medical staff and social worker teams. HIV should increasingly be regarded as a chronic disease characterized by different pathological conditions requiring a comprehensive and multidisciplinary approach.
authors.affiliation: 1 INSERM Research Unit 379 Epidemiology and Social Sciences Applied to Medical Innovation, Marseille, France.
authors.forename: Marie
authors.initials: M
authors.lastname: Préau
authors.forename: Fabienne
authors.initials: F
authors.lastname: Marcellin
authors.forename: Marie Patrizia
authors.initials: MP
authors.lastname: Carrieri
authors.forename: France
authors.initials: F
authors.lastname: Lert
authors.forename: Yolande
authors.initials: Y
authors.lastname: Obadia
authors.forename: Bruno
authors.initials: B
authors.lastname: Spire
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active; D001294:Attitude to Health; D004812:Epidemiologic Methods; D005260:Female; D015658:HIV Infections / Q000188:drug therapy / Q000523:psychology / Q000534:rehabilitation*; D006305:Health Status Indicators; D006801:Humans; D008297:Male; D008603:Mental Health; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D011594:Psychometrics; D011788:Quality of Life; D015983:Selection Bias
chemical_list: D019380:Anti-HIV Agents