Eruptive cherry angiomas associated with vitiligo: provoked by topical nitrogen mustard?
We report a 27-year-old man who had suffered with vitiligo for 7 years and with eruptive cherry angiomas within or around the repigmented vitiliginous skin for 2 years. After continual therapy for vitiligo with topical nitrogen mustard in a concentration of 0.001% for 5 years, multiple cherry angiomas erupted within or around the repigmented vitiliginous plaques. The discontinue therapy with nitrogen mustard stopped the appearance of new cherry angiomas. The presence of eruptive cherry angiomas was evident and was confirmed by histopathology. We suggest that the chronic chemical stimuli caused by topical nitrogen mustard might result in the formation of eruptive cherry angiomas.
Ma
Hui-Jun
HJ
Department of Dermatology, The Airforce General Hospital of Chinese People's Liberation Army, Beijing, China. melanocytes@163.com
Zhao
Guang
G
Shi
Fei
F
Wang
Yi-Xia
YX
D000328:Adult; D000477:Alkylating Agents / Q000009:adverse effects*; D002196:Capillaries / Q000473:pathology; D003879:Dermatologic Agents / Q000009:adverse effects*; D006391:Hemangioma / Q000139:chemically induced* / Q000473:pathology; D006801:Humans; D008297:Male; D008466:Mechlorethamine / Q000009:adverse effects*; D012878:Skin Neoplasms / Q000139:chemically induced* / Q000473:pathology; D012880:Skin Pigmentation / Q000187:drug effects; D013684:Telangiectasis / Q000473:pathology; D014820:Vitiligo / Q000188:drug therapy*
D000477:Alkylating Agents; D003879:Dermatologic Agents; D008466:Mechlorethamine