title: Cyclooxygenase-2 and colorectal cancer chemoprevention: the beta-catenin connection.
abstract: Colorectal cancer poses a major clinical challenge in the developed world where this disease is common. Recent findings suggest that the prostaglandin E(2), the proinflammatory product of elevated cyclooxygenase-2 activity in colon cancer, stimulates cancer cell growth through a G protein-dependent signaling pathway coupling the prostaglandin EP2 receptor to beta-catenin control. These findings provide new insights into the molecular framework needed to evaluate chemopreventive strategies for colorectal cancer.
authors.affiliation: Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, NIH, Bethesda, Maryland 20892-4340, USA.
authors.forename: Maria Domenica
authors.initials: MD
authors.lastname: Castellone
authors.forename: Hidemi
authors.initials: H
authors.lastname: Teramoto
authors.forename: J Silvio
authors.initials: JS
authors.lastname: Gutkind
mesh_terms: D015179:Colorectal Neoplasms / Q000378:metabolism / Q000503:physiopathology / Q000517:prevention & control*; D051546:Cyclooxygenase 2 / Q000378:metabolism*; D052246:Cyclooxygenase 2 Inhibitors / Q000627:therapeutic use*; D015232:Dinoprostone / Q000378:metabolism; D019204:GTP-Binding Proteins / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D018078:Receptors, Prostaglandin E / Q000502:physiology; D058307:Receptors, Prostaglandin E, EP2 Subtype; D015398:Signal Transduction / Q000502:physiology; D051176:beta Catenin / Q000502:physiology
chemical_list: D052246:Cyclooxygenase 2 Inhibitors; C545644:PTGER2 protein, human; D018078:Receptors, Prostaglandin E; D058307:Receptors, Prostaglandin E, EP2 Subtype; D051176:beta Catenin; D051546:Cyclooxygenase 2; D019204:GTP-Binding Proteins; D015232:Dinoprostone