Relationship between serum resistin concentrations and inflammatory markers in patients with type 2 diabetes mellitus.
To examine whether serum resistin concentrations are associated with metabolic or inflammatory markers in patients with type 2 diabetes mellitus, we examined serum concentrations levels and metabolic or inflammatory markers in 56 patients with type 2 diabetes mellitus and 41 healthy subjects. Serum levels of resistin, serum amyloid A, and soluble vascular cell adhesion molecule-1 were measured by enzyme-linked immunosorbent assay. Serum resistin levels were significantly elevated in diabetic patients compared with those in healthy subjects. Serum resistin concentrations did not correlate with body mass index; however, there was a significant positive correlation between resistin and soluble vascular cell adhesion molecule-1 in diabetic patients. Based on the present results, we conclude that resistin appears to be associated with vascular inflammatory markers in patients with type 2 diabetes mellitus.
Hui-Bing
Huang
H
Department of Endocrinology and Metabolism, NHO Nagasaki Medical Center, Omura 856-8652, Japan.
Migita
Kiyoshi
K
Miyashita
Taichiro
T
Maeda
Yumi
Y
Nakamura
Minoru
M
Yatsuhashi
Hiroshi
H
Ishibashi
Hiromi
H
Eguchi
Katsumi
K
Kimura
Hironori
H
D000328:Adult; D000368:Aged; D015415:Biomarkers; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D052243:Resistin / Q000097:blood*; D000685:Serum Amyloid A Protein / Q000032:analysis*; D019010:Vascular Cell Adhesion Molecule-1 / Q000097:blood*
D015415:Biomarkers; D015850:Interleukin-6; C499624:RETN protein, human; D052243:Resistin; D000685:Serum Amyloid A Protein; D019010:Vascular Cell Adhesion Molecule-1