[Genetic relationships of Moscow and foreign strains of Haemophilus influenzae, serotype B].
46 Haemophilus influenzae strains of serotype b, isolated on the territory of Moscow and compared with foreign strains, were characterized by the method of multilocus sequencing-typing. Among the strains circulating in Moscow 10 variants of sequence-types were observed; of these, only one variant (CT-6) had been described earlier. The analysis of the data revealed that the strains under study were distributed in two clonal complexes; the overwhelming majority of the strains belonged to sequence-type 6. The distribution of Moscow strains in clonal complexes repeated the clonal organization detected in foreign strains. The conclusion was made that lower morbidity rate in Hib meningitis in Moscow (in comparison with that in the countries of Europe and America before the introduction of prophylactic vaccination) was not due to the peculiar genetic features of the circulating strains.
Mironov
K O
KO
Platonov
A E
AE
Koroleva
I S
IS
Shipulin
G A
GA
D000569:Americas; D002675:Child, Preschool; D016000:Cluster Analysis; D017931:DNA Primers; D005060:Europe; D005787:Gene Frequency; D005798:Genes, Bacterial; D014644:Genetic Variation; D006192:Haemophilus Infections / Q000382:microbiology*; D019741:Haemophilus influenzae type b / Q000145:classification / Q000235:genetics* / Q000472:pathogenicity; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D009031:Moscow; D020539:Sequence Analysis, Protein; D012984:Software; D014774:Virulence / Q000235:genetics
D017931:DNA Primers