title: Cracking up: symmetry breaking in cellular systems.
abstract: The shape of animal cells is, to a large extent, determined by the cortical actin network that underlies the cell membrane. Because of the presence of myosin motors, the actin cortex is under tension, and local relaxation of this tension can result in cortical flows that lead to deformation and polarization of the cell. Cortex relaxation is often regulated by polarizing signals, but the cortex can also rupture and relax spontaneously. A similar tension-induced polarization is observed in actin gels growing around beads, and we propose that a common mechanism governs actin gel rupture in both systems.
authors.affiliation: Max Planck Institute of Molecular Cell Biology and Genetics, Dresden 01307, Germany.
authors.forename: Ewa
authors.initials: E
authors.lastname: Paluch
authors.forename: Jasper
authors.initials: J
authors.lastname: van der Gucht
authors.forename: Cécile
authors.initials: C
authors.lastname: Sykes
mesh_terms: D000199:Actins / Q000737:chemistry*; D000818:Animals; D002477:Cells / Q000737:chemistry*; D022082:Cellular Structures / Q000737:chemistry*; D005782:Gels / Q000737:chemistry; D040542:Mechanotransduction, Cellular / Q000502:physiology; D013314:Stress, Mechanical
chemical_list: D000199:Actins; D005782:Gels