title: Evidence that RpoS (sigmaS) in Borrelia burgdorferi is controlled directly by RpoN (sigma54/sigmaN).
abstract: The alternative sigma factor (RpoN-RpoS) pathway controls the expression of key virulence factors in Borrelia burgdorferi. However, evidence to support whether RpoN controls rpoS directly or, perhaps, indirectly via a transactivator has been lacking. Herein we provide biochemical and genetic evidence that RpoN directly controls rpoS in B. burgdorferi.
authors.affiliation: Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9048, USA.
authors.forename: Alexandra H
authors.initials: AH
authors.lastname: Smith
authors.forename: Jon S
authors.initials: JS
authors.lastname: Blevins
authors.forename: Gulnaz N
authors.initials: GN
authors.lastname: Bachlani
authors.forename: Xiaofeng F
authors.initials: XF
authors.lastname: Yang
authors.forename: Michael V
authors.initials: MV
authors.lastname: Norgard
mesh_terms: D000942:Antigens, Bacterial / Q000235:genetics; D001425:Bacterial Outer Membrane Proteins / Q000235:genetics; D001426:Bacterial Proteins / Q000235:genetics*; D001483:Base Sequence; D001665:Binding Sites; D025065:Borrelia burgdorferi / Q000235:genetics*; D015964:Gene Expression Regulation, Bacterial; D008969:Molecular Sequence Data; D016297:Mutagenesis, Site-Directed; D011401:Promoter Regions, Genetic; D051877:RNA Polymerase Sigma 54 / Q000502:physiology*; D012808:Sigma Factor / Q000235:genetics*
chemical_list: D000942:Antigens, Bacterial; D001425:Bacterial Outer Membrane Proteins; D001426:Bacterial Proteins; C079616:OspC protein; D012808:Sigma Factor; C069567:sigma factor KatF protein, Bacteria; D051877:RNA Polymerase Sigma 54