[Fatty acid mobilization and their use in adipose tissue].
An excess of fat mass excess predisposes to multiple complications such as type 2 diabetes, cardiovascular diseases or cancer. A dysregulation of lipid metabolism contributes to the development of obesity and the metabolic syndrome. Recent data on lipid mobilization in adipose tissue have revealed a complex pathway involving a human specific hormonal control of lipolysis via the natriuretic peptides and a new triglyceride lipase, ATGL. Activation of fatty acid reesterification and oxidation can lead to an increase in fatty acid utilization. Targeting these key steps of lipid metabolism (adipose tissue lipolysis and fatty acid oxidation) constitutes a potential strategy for the treatment of obesity and associated metabolic disorders.
Mazzucotelli
Anne
A
INSERM U586, Unité de recherche sur les obésités, Toulouse, F-31432 France.
Langin
Dominique
D
D000273:Adipose Tissue / Q000502:physiology* / Q000503:physiopathology; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000503:physiopathology / Q000517:prevention & control; D015444:Exercise; D005227:Fatty Acids / Q000378:metabolism*; D006801:Humans; D008053:Lipid Mobilization / Q000502:physiology*; D008066:Lipolysis / Q000502:physiology; D008954:Models, Biological; D009765:Obesity / Q000503:physiopathology / Q000517:prevention & control
D005227:Fatty Acids