Lens induction in vertebrates: variations on a conserved theme of signaling events.
This review provides an overview of our current understanding of signaling mechanisms involved in lens induction, which are presented in context of the major stages of lens induction (competence, bias, inhibition and specification). Although the process of lens induction is generally well conserved, we highlight aspects of induction that vary among species. Finally, this review identifies future challenges in forming an integrated network of signaling pathways involved in lens induction.
Donner
Amy L
AL
Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. adonner@rics.bwh.harvard.edu
Lachke
Salil A
SA
Maas
Richard L
RL
D000818:Animals; D017124:Conserved Sequence; D004627:Embryonic Induction / Q000502:physiology*; D006801:Humans; D007908:Lens, Crystalline / Q000737:chemistry / Q000196:embryology* / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*