Pinkus tumor may originate from intraepidermal eccrine ducts and proliferate in the dermis.
To clarify the histopathogenesis of Pinkus tumor (fibroepithelial basal cell carcinoma, FEBCC), we have studied cytokeratin (CK) expression in FEBCC using ten different anti-keratin antibodies against CK 1, 7, 8, 10, 14, 15, 16, 17, 18 and 19. Tumor nests consisted of two epithelial components: duct-like structures and basaloid cells of anastomosing strands. In duct-like structure, CK 1, 10, 14, 16, 17 and 19 were detected. CK expression of duct-like structure showed the hyperproliferative state of eccrine intraepidermal ducts. In basaloid cells of anastomosing strands, CK 14 and 17 were detectable. These results suggested that duct-like structure originates from the intraepidermal duct and proliferates to spread in the dermis.
Kurokawa
Ichiro
I
Department of Dermatology, Mie University Graduate School of Medicine, 2-174 Edobachi, Tsu, Mie 514-8507, Japan. kuroichi@clin.medic.mie-u.ac.jp
Yokoyama
Tomoya
T
Nishimura
Keisuke
K
Hakamada
Arata
A
Isoda
Ken-ichi
K
Yamanaka
Kei-ichi
K
Tsubura
Airo
A
Mizutani
Hitoshi
H
D000369:Aged, 80 and over; D000906:Antibodies / Q000276:immunology; D002280:Basal Cell Carcinoma / Q000378:metabolism / Q000473:pathology*; D004439:Eccrine Glands / Q000378:metabolism / Q000473:pathology*; D004801:Eosine Yellowish-(YS); D004847:Epithelial Cells / Q000378:metabolism / Q000473:pathology; D006416:Hematoxylin; D006801:Humans; D007150:Immunohistochemistry; D007633:Keratins / Q000096:biosynthesis / Q000276:immunology; D008297:Male; D018225:Neoplasms, Fibroepithelial / Q000378:metabolism / Q000473:pathology*; D012878:Skin Neoplasms / Q000378:metabolism / Q000473:pathology*; D013194:Staining and Labeling / Q000379:methods
D000906:Antibodies; D007633:Keratins; D004801:Eosine Yellowish-(YS); D006416:Hematoxylin