title: Increased inhibitory input to CA1 pyramidal cells alters hippocampal gamma frequency oscillations in the MK-801 model of acute psychosis.
abstract: The phencyclidine compound MK-801 can induce psychosis with symptoms which closely resemble those observed in an acute schizophrenic episode. Here we used an in vitro model of psychosis after systemic administration of MK-801. We found that kainate-induced gamma frequency field oscillations in animals previously exposed to MK-801 have significantly higher power than in control animals. The intrinsic membrane properties of pyramidal cells, such as membrane input resistance and time constant, were not found to be different. In contrast, the MK-801 cells exhibited significantly more depolarized resting membrane potentials than control cells. We propose cellular alterations in Na+-K+-pump activity and increases in phasic inhibition in MK-801 cells to be the respective underlying mechanisms responsible for the more depolarized resting membrane potentials and the increased power of gamma frequency oscillations observed in MK-801 pretreated animals.
authors.affiliation: Institute of Neurophysiology, Charité-Universitätsmedizin Berlin, Tucholskystr. 2, 10117 Berlin, Germany.
authors.forename: Colin
authors.initials: C
authors.lastname: Kehrer
authors.forename: Tamar
authors.initials: T
authors.lastname: Dugladze
authors.forename: Nino
authors.initials: N
authors.lastname: Maziashvili
authors.forename: Anna
authors.initials: A
authors.lastname: Wójtowicz
authors.forename: Dietmar
authors.initials: D
authors.lastname: Schmitz
authors.forename: Uwe
authors.initials: U
authors.lastname: Heinemann
authors.forename: Tengis
authors.initials: T
authors.lastname: Gloveli
mesh_terms: D000208:Acute Disease; D000818:Animals; D004195:Disease Models, Animal; D016291:Dizocilpine Maleate / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000494:pharmacology; D018690:Excitatory Amino Acid Agonists / Q000494:pharmacology; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology*; D006624:Hippocampus / Q000166:cytology / Q000187:drug effects / Q000503:physiopathology*; D053444:Inhibitory Postsynaptic Potentials / Q000187:drug effects / Q000502:physiology; D007608:Kainic Acid / Q000494:pharmacology; D051379:Mice; D008810:Mice, Inbred C57BL; D009433:Neural Inhibition / Q000187:drug effects; D009924:Organ Culture Techniques; D010042:Ouabain / Q000494:pharmacology; D011605:Psychoses, Substance-Induced / Q000503:physiopathology; D017966:Pyramidal Cells / Q000187:drug effects* / Q000502:physiology; D012559:Schizophrenia / Q000139:chemically induced / Q000503:physiopathology*; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors / Q000378:metabolism
chemical_list: D004791:Enzyme Inhibitors; D018690:Excitatory Amino Acid Agonists; D018691:Excitatory Amino Acid Antagonists; D010042:Ouabain; D016291:Dizocilpine Maleate; D000254:Sodium-Potassium-Exchanging ATPase; D007608:Kainic Acid