Synthesis of L-beta-3'-deoxy-3',3'-difluoro-4'-thionucleosides.
[Structure: see text] An efficient route to L-beta-3'-deoxy-3',3'-difluoro-4'-thionucleosides, thio-containing analogues of highly bioactive gemcitabine, is described. Our synthesis highlighted the installation of the thioacetyl group in high efficiency and construction of 3-deoxy-3,3-difluorothiofuranose skeleton in a novel method.
Zheng
Feng
F
Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, China.
Zhang
Xiao-Hua
XH
Qiu
Xiao-Long
XL
Zhang
Xingang
X
Qing
Feng-Ling
FL
D008958:Models, Molecular; D019906:Nuclear Magnetic Resonance, Biomolecular; D013872:Thionucleosides / Q000138:chemical synthesis*
D013872:Thionucleosides