[Clinical study on pulmonary complications after allogeneic peripheral blood stem cell transplantation].
OBJECTIVE
To explore the incidence, pathogenesis, risk factors and effective treatment of pulmonary complications after allogeneic peripheral blood stem cell transplantation (allo-PBSCT).


METHODS
Pulmonary complications in 70 patients received allo-PBSCT were analyzed.


RESULTS
Thirty one episodes were observed in 26 patients. Among them episodes were infectious complications, including bacteria pneumonia, pulmonary fungus disease, CMV interstitial pneumonia and tuberculosis, some cases were caused by two pathogens, and 11 episodes were noninfectious complications, including late-onset noninfectious pulmonary complications (LONIPCs) (n=9), pulmonary edema (n=1) and interstitial pneumonia (n=1). The overall mortality was 12.9%. Graft-versus-host disease (GVHD) prophylaxis without MTX, severe acute GVHD and extensive chronic GVHD were high risk factors for pulmonary complications and advanced disease at transplantation, extensive chronic GVHD were significantly associated with the incidence of LONIPCs.


CONCLUSIONS
Pulmonary disease is the main complication occurred in patients undergoing allo-PBSCT. It is of greatly importance to treat pathogens specifically and diagnose LONIPCs in its early stage.
Zhang
Yi-zhuo
YZ
Department of Hematology, PLA General Hospital, Beijing 100853, China.
Da
Wan-ming
WM
Zhang
Bo-Long
BL
Gao
Chun-Ji
CJ
Han
Xiao-pin
XP
Huang
Wen-rong
WR
Jing
Yu
Y
Li
Hong-hua
HH
Zhao
Yu
Y
Bo
Jian
J
Wang
Shu-hong
SH
Zhu
Hai-yan
HY
Jin
Hai-jie
HJ
D000293:Adolescent; D000328:Adult; D005260:Female; D006086:Graft vs Host Disease / Q000517:prevention & control; D006402:Hematologic Diseases / Q000601:surgery; D006801:Humans; D008171:Lung Diseases / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D036102:Peripheral Blood Stem Cell Transplantation / Q000009:adverse effects*