[Analysis of sensitivity of stromal stem cells (CFU-f) from rat bone marrow and fetal liver to 5-fluorouracil].
The sensitivity of stromal stem cells (CFU-f) from rat bone marrow and fetal liver to the cytotoxic effect of 5-fluorouracil (5-FU) was compared in vivo and in vitro. Cells from both tissues demonstrated a similar resistance to 5-FU in vitro; however, stromal stem cells from fetal liver proved notably more sensitive to 5-FU compared to marrow CFU-f in vivo. Cells forming colonies of different size were identified in stem cell populations from both tissues. Cells giving rise to small colonies had a higher resistance to 5-FU both in vivo and in vitro.
Paiushina
O V
OV
Damaratskaia
E I
EI
Bueverova
E I
EI
Nikonova
T M
TM
Butorina
N N
NN
Molchanova
E A
EA
Starostin
V I
VI
D000818:Animals; D000963:Antimetabolites / Q000494:pharmacology*; D001853:Bone Marrow / Q000378:metabolism*; D002478:Cells, Cultured; D003114:Colony-Forming Units Assay / Q000379:methods; D004351:Drug Resistance / Q000187:drug effects / Q000502:physiology*; D005260:Female; D005333:Fetus / Q000166:cytology / Q000378:metabolism; D005472:Fluorouracil / Q000494:pharmacology*; D008099:Liver / Q000166:cytology / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D013234:Stem Cells / Q000166:cytology / Q000378:metabolism*; D017154:Stromal Cells / Q000166:cytology / Q000378:metabolism
D000963:Antimetabolites; D005472:Fluorouracil