title: Adiponectin and cardiovascular disease: state of the art?
abstract: The cardiometabolic syndrome, associated with increased cardiovascular disease risk in the industrialized world, is estimated to affect one in four adults. Although the mechanisms linking obesity and cardiovascular disease remain unclear, research continues to unravel the molecular pathways behind this pandemic. Adipose tissue has emerged as a metabolically active participant in mediating vascular complications, serving as an active endocrine and paracrine organ secreting adipokines, which participate in diverse metabolic processes. Among these adipokines is adiponectin, which seems to possess antiatherogenic and anti-inflammatory effects and may be protective against cardiovascular disease development. The current review describes the pathophysiology of adiponectin in atherosclerotic disease.
authors.affiliation: Department of General Internal Medicine, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Paul E
authors.initials: PE
authors.lastname: Szmitko
authors.forename: Hwee
authors.initials: H
authors.lastname: Teoh
authors.forename: Duncan J
authors.initials: DJ
authors.lastname: Stewart
authors.forename: Subodh
authors.initials: S
authors.lastname: Verma
mesh_terms: D052242:Adiponectin / Q000502:physiology*; D000818:Animals; D002318:Cardiovascular Diseases / Q000378:metabolism* / Q000503:physiopathology*; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology; D024821:Metabolic Syndrome / Q000378:metabolism* / Q000503:physiopathology*; D009765:Obesity / Q000378:metabolism / Q000503:physiopathology
chemical_list: D052242:Adiponectin