Flushing out of cerebrospinal fluid as a therapy for acute cerebellar dysfunction caused by high dose of cytosine arabinoside: a case report.
High dose of cytosine arabinoside is usually used in treatment of acute myelogenous leukemia. Here we report 1 case of a child who developed neurologic toxicity and rapidly improved after flushing out of cerebral spinal fluid, suggesting it could be treatment in the acute phase of toxicity. Efficacy of this treatment could be explained by reducing cytosine arabinoside metabolites in central nervous system.
Pellier
Isabelle
I
Unité d'Hematologie-Immunologie-Oncologie Pédiatrique, CHU Angers, France. IsPellier@chu-angers.fr
Leboucher
Bertrand
B
Rachieru
Petronela
P
Ifrah
Norbert
N
Rialland
Xavier
X
D000293:Adolescent; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage / Q000009:adverse effects*; D002526:Cerebellar Diseases / Q000139:chemically induced* / Q000628:therapy*; D002555:Cerebrospinal Fluid; D003561:Cytarabine / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000150:complications / Q000188:drug therapy*; D008297:Male
D000964:Antimetabolites, Antineoplastic; D003561:Cytarabine