title: Characterisation of some experimental silicones.
abstract: Release of antimicrobials/antibacterials like chlorhexidine diacetate (CHD) has proved successful in inhibiting Candidal colonisation of silicone-based biomaterials. However, their addition will increase water uptake and may compromise the mechanical integrity. Two experimental silicones (S1 and S2) differing only in the surface treatment of the filler, were investigated. Ultimate tensile strength (UTS), % elongation at break (Eb), Shore A hardness and, when doped with 1% CHD, water uptake and CHD release were measured. Elastic modulus (E) was calculated from the hardness measurements. There was no significant difference in UTS and Eb between the two materials. However S1 had a higher hardness (30.6 +/- 0.97) and thus E (0.76 MPa) than S2 (hardness = 23.8 +/- 0.48, E = 0.45 MPa). Water uptake for S2 (0.6%) was higher than for S2 (0.1) and addition of CHD dramatically increased the uptake of both (S1 = 3.1%, S2 = 4.0%). Release of CHD was higher for S2 (30%) than S1 (27%). Equating osmotic pressure within the droplets with elastic restraining force gave an extension ratio of 1.95 for S1 and 5.39 for S2. Thus, addition of a hydrophilic agent can compromise the mechanical integrity of low modulus silicones.
authors.affiliation: Biomaterials in Relation to Dentistry, IRC in Biomedical Materials, Barts & the London, Queen Mary's School of Medicine & Dentistry, Francis Bancoft Building, Mile End Road, London, E1 4NS, UK. s.parker@qmul.ac.uk
authors.forename: S
authors.initials: S
authors.lastname: Parker
authors.forename: I
authors.initials: I
authors.lastname: Meththananda
authors.forename: M
authors.initials: M
authors.lastname: Braden
authors.forename: G J
authors.initials: GJ
authors.lastname: Pearson
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry*; D002710:Chlorhexidine / Q000031:analogs & derivatives / Q000737:chemistry; D004548:Elasticity; D006244:Hardness; D008422:Materials Testing; D012828:Silicones / Q000737:chemistry*; D013718:Tensile Strength; D014867:Water
chemical_list: D001672:Biocompatible Materials; D012828:Silicones; D014867:Water; D002710:Chlorhexidine