[Fasting serum glucose level and gastric cancer risk in a nested case-control study].
OBJECTIVE
Diabetes has been reported as a risk factor for several cancers. However, the association between diabetes and gastric cancer has been inconsistent. The aim of this study was to evaluate the association between the fasting serum glucose level and gastric cancer risk in Korea.


METHODS
Among the members of the Korean MultiCenter Cancer Cohort (KMCC) from 1993 to 2004, a total of 100 incident gastric cancer cases were ascertained until December 31, 2002 and 400 controls were matched according to age, sex, and year and area of enrollment. Of the eligible subjects, those without fasting serum glucose level information were excluded, with a total of 64 cases and 236 controls finally selected. On enrollment, all subjects completed a baseline demographic and lifestyle characteristics questionnaire, and had their fasting serum glucose level measured. The Helicobacter pylori infection status was determined by an immunoblot assay using long-term stored serum. The odds ratios (ORs) were estimated using conditional and unconditional logistic regression models adjusted for the H. pylori infection status, smoking, drinking, education, follow-up period and matching variables.


RESULTS
The ORs for risk of gastric cancer according to the serum glucose level were 1.33 [95% CI=0.50-3.53] and 1.66 [95% CI=0.55-5.02] for the categories of 100-125 and 126 mg/dL or greater, respectively, compared to the category of less than 100 mg/dL. No increased risk of gastric cancer according to the serum glucose level was found (p-trend=0.337).


CONCLUSIONS
This study provides no evidence for an association of the serum glucose level with gastric cancer.
Jun
Jae Kwan
JK
Department of Preventive Medicine, Seoul National University College of Medicine.
Gwack
Jin
J
Park
Sue Kyung
SK
Choi
Yun-Hee
YH
Kim
Yeonju
Y
Shin
Aesun
A
Chang
Soung-Hoon
SH
Shin
Hai-Rim
HR
Yoo
Keun-Young
KY
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001786:Blood Glucose / Q000032:analysis*; D016022:Case-Control Studies; D005215:Fasting; D005260:Female; D006801:Humans; D007723:Korea / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D012306:Risk; D013274:Stomach Neoplasms / Q000453:epidemiology* / Q000378:metabolism*
D001786:Blood Glucose