Clinical resolution of a neonatally eroded giant congenital melanocytic nevus.
We report an unusual occurrence of spontaneous pigmentary regression with a desmoplastic reaction in a neonatally eroded giant congenital melanocytic nevus. This process has been documented with photographs and skin biopsy specimens. Neonatal histology demonstrated connective tissue proliferation. Histology at age 5 years also demonstrated a very high proportion of amelanotic dermal nevus cells. Regression of pigmentation in our patient may be due to a decrease in melanin production by dermal nevus cells rather than a decrease in their number.
Gass
Julia K
JK
Depatment of Dermatology, Cambridge University Hospitals NHS Foundation Trust, Addenbrooke's Hospital, Cambridge, UK. julia.gass@addenbrookes.nhs.uk
Grant
John W
JW
Hall
Per N
PN
Atherton
David J
DJ
Burrows
Nigel P
NP
D002675:Child, Preschool; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009508:Nevus, Pigmented / Q000175:diagnosis* / Q000473:pathology*; D012075:Remission, Spontaneous