The recognition of Z-DNA by chiral helicene.
Enantiomeric helicenes of (P)-A and (M)-A were synthesized. The binding of the helicenes to B- and Z-DNA was studied quantitatively by CD, equilibrium dialysis, and fluorescence spectroscopy. Enantiomeric (P)-A not only bound selectively to Z-DNA, but also effectively converted the B-DNA conformation to Z-DNA. The enantio-selectivity of the helicenes offers a new route for the rational design of inhibitors of biological functions that may depend on Z-DNA.
Xu
Yan
Y
Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo, Kyoto 606-8501, Japan.
Sugiyama
Hiroshi
H
Tanaka
Kazuhiko
K
Osuga
Hideji
H
D002942:Circular Dichroism; D043542:DNA, Z-Form / Q000737:chemistry*; D007700:Kinetics; D008958:Models, Molecular; D011083:Polycyclic Compounds / Q000737:chemistry*; D013816:Thermodynamics
D043542:DNA, Z-Form; D011083:Polycyclic Compounds; C031660:helicenes