title: Mitoxantrone-related acute myeloblastic leukaemia in a patient with metastatic hormone-refractory prostate cancer.
abstract: Mitoxantrone is a DNA topoisomerase II poison commonly used for the treatment of hormone-refractory prostate cancer. The risk of secondary leukaemia is well described after mitoxantrone treatment in breast cancer and multiple sclerosis. Recent improvements of systemic chemotherapy increased the median survival in patients becoming resistant to androgen deprivation from 10 to 18 months. As a consequence, chemotherapy-related cumulative toxicities may become a more prominent clinical problem in this patient population. We report here the first case report of secondary leukaemia induced by mitoxantrone in metastatic hormone-refractory prostate cancer. This clinical observation invites us to reconsider the number of administrations to be recommended for mitoxantrone-sensitive metastatic prostate cancer patients.
authors.affiliation: Department of Internal Medicine, Assistance Publique-Hôpitaux de Paris, Teaching Hospital Cochin, University Paris 5, 27 rue du Faubourg Saint Jacques, 75679 Paris cedex 14, France.
authors.forename: Valérie
authors.initials: V
authors.lastname: Martinez
authors.forename: Olivier
authors.initials: O
authors.lastname: Mir
authors.forename: Julien
authors.initials: J
authors.lastname: Dômont
authors.forename: Didier
authors.initials: D
authors.lastname: Bouscary
authors.forename: François
authors.initials: F
authors.lastname: Goldwasser
mesh_terms: D000728:Androgens / Q000502:physiology*; D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D003561:Cytarabine / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D017403:In Situ Hybridization; D015470:Leukemia, Myeloid, Acute / Q000139:chemically induced*; D008297:Male; D008875:Middle Aged; D008942:Mitoxantrone / Q000009:adverse effects* / Q000627:therapeutic use; D009362:Neoplasm Metastasis; D011471:Prostatic Neoplasms / Q000150:complications* / Q000473:pathology
chemical_list: D000728:Androgens; D000964:Antimetabolites, Antineoplastic; D000970:Antineoplastic Agents; D003561:Cytarabine; D008942:Mitoxantrone