title: Neuropharmacological properties of Xylocarpus moluccensis.
abstract: The methanolic extracts of the barks and pneumatophores of Xylocarpus moluccensis were assessed for their effects on the central nervous system (CNS) using a series of established pharmacological tests including pentobarbitone-induced sleeping time, open field, hole cross, hole-board and evasions tests in mice model. These extracts produced a dose-dependent reduction of the onset and duration of pentobarbitone-induced hypnosis, reduction of locomotor and exploratory activities in the open field, hole cross, head-dip and evasion tests. These results suggest that both the bark and pneumatophore extracts possess CNS depressant activity, the pneumatophore extract being more potent than the bark extract.
authors.affiliation: School of Biomedical Sciences, University of Ulster at Coleraine, Cromore Road, Coleraine BT52 1SA, Co. Londonderry, Northern Ireland, UK. s.sarker@ulster.ac.uk
authors.forename: Satyajit D
authors.initials: SD
authors.lastname: Sarker
authors.forename: Shaikh J
authors.initials: SJ
authors.lastname: Uddin
authors.forename: Jamil A
authors.initials: JA
authors.lastname: Shilpi
authors.forename: Razina
authors.initials: R
authors.lastname: Rouf
authors.forename: Monzur-E-Mohsina
authors.initials: ME
authors.lastname: Ferdous
authors.forename: Lutfun
authors.initials: L
authors.lastname: Nahar
mesh_terms: D000818:Animals; D002490:Central Nervous System / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006993:Hypnotics and Sedatives / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D029582:Meliaceae; D051379:Mice; D010424:Pentobarbital; D008517:Phytotherapy; D024301:Plant Bark; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018514:Plant Structures; D011597:Psychomotor Performance / Q000187:drug effects; D012890:Sleep / Q000187:drug effects*
chemical_list: D006993:Hypnotics and Sedatives; D010936:Plant Extracts; D010424:Pentobarbital