title: Pediatric penile tumors of mesenchymal origin.
abstract: OBJECTIVE
  To describe 2 cases of mesenchymal pediatric penile tumors in a 13-year-old boy and an 11-month-old infant. Mesenchymal tumors are rare in the male external genitalia.
  
  
  METHODS
  Two patients, one aged 13 years and one 11 months, presented with painless penile masses at the penoscrotal junction. The evaluation included serial clinical examinations and ultrasonography. Both lesions were surgically excised after increasing in size. Because of malignancy, the first patient underwent wide reexcision of the tumor site.
  
  
  RESULTS
  The pathologic findings of the first case were combined dermatofibrosarcoma protuberans, giant cell fibroblastoma, and fibrosarcoma, a malignant tumor. Immunohistochemical staining showed strong and diffuse CD34 cytoplasmic positivity in the giant cell fibroblastoma and dermatofibrosarcoma protuberans components; the dedifferentiated fibrosarcoma tumor cells were negative for this antibody. The second case was myofibroma, a benign fibroblastic tumor with a prominent myofibroblastic component that is congenital and tends to occur within the first few months after birth. Neither patient had recurrence at 16 months and 3 years of follow-up. To our knowledge, this is the first reported case of combined dermatofibrosarcoma protuberans, giant cell fibroblastoma, and fibrosarcoma of the penis and the second reported case of isolated penile myofibroma.
  
  
  CONCLUSIONS
  Penile tumors should be included in the differential diagnosis of pediatric penile masses. Surgical resection is often curative, but patients with malignant tumors should receive careful follow-up to monitor for recurrence.
authors.affiliation: Department of Urology, Children's Hospital Boston, Boston, Massachusetts, USA. beisner@partners.org
authors.forename: Brian H
authors.initials: BH
authors.lastname: Eisner
authors.forename: Sarah J
authors.initials: SJ
authors.lastname: McAleer
authors.forename: Patricio C
authors.initials: PC
authors.lastname: Gargollo
authors.forename: Antonio
authors.initials: A
authors.lastname: Perez-Atayde
authors.forename: David A
authors.initials: DA
authors.lastname: Diamond
authors.forename: Jack S
authors.initials: JS
authors.lastname: Elder
mesh_terms: D000293:Adolescent; D003937:Diagnosis, Differential; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D008297:Male; D008637:Mesenchymoma / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D010412:Penile Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D018608:Ultrasonography, Doppler; D013521:Urologic Surgical Procedures, Male / Q000379:methods