[The relationship between ACE I/D polymorphism and HDL cholesterol].
OBJECTIVE
The purpose of this study is to evaluate the association of the angiotensin converting enzyme (ACE) insertion/deletion (I/D) polymorphism with cardiovascular disease risk factors.


METHODS
Out of a total of 608 middle-aged adults who visited local health centers, 424 subjects (104 male, 320 female) who had not been diagnosed with hypertension, diabetes mellitus, or hyperlipidemia were included in this study. ACE genotypes were determined in all subjects by polymerase chain reaction methods.


RESULTS
Statistical differences in high-density lipoprotein (HDL) cholesterol levels according to ACE genotype were observed using ANOVA (p<0.05), but no differences were found in other cardiovascular risk factors. Specifically, men with the DD and DI genotypes had significantly lower HDL cholesterol levels than those with the II genotype based on the LSD multi-comparison test (p<0.05).


CONCLUSIONS
In men, the D-allele of the ACE I/D polymorphism was significantly associated with reduced HDL cholesterol levels. In the future, larger studies are needed to confirm this relationship between ACE I/D polymorphism and HDL cholesterol.
You
Chang Hun
CH
Department of Preventive Medicine, Medical Research Center for Cancer Molecular Therapy, College of Medicine, Dong-A University.
Hong
Young Seoub
YS
Kwak
Jong Young
JY
Kim
Na Young
NY
Roh
Mee Sook
MS
Jung
Kap Yeol
KY
Lee
Yong Hwan
YH
Kim
Jung Man
JM
Kim
Joon Youn
JY
D002318:Cardiovascular Diseases / Q000235:genetics / Q000503:physiopathology; D008076:Cholesterol, HDL / Q000097:blood*; D005260:Female; D015438:Health Behavior; D006801:Humans; D008297:Male; D008875:Middle Aged; D016254:Mutagenesis, Insertional; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D012307:Risk Factors; D017384:Sequence Deletion
D008076:Cholesterol, HDL; D007703:Peptidyl-Dipeptidase A