title: Design, synthesis, and anticancer activity of fluorocyclopentenyl-pyrimidines.
abstract: Novel pyrimidine nucleosides with fluorocyclopentene ring were synthesized from D-ribose via stereoselective Grignard reaction and electrophilic vinyl fluorination as key steps. Among compounds tested, cytosine derivative 15a was found to show high growth inhibition against a broad range of human tumor cell lines.
authors.affiliation: Laboratory of Medicinal Chemistry, College of Pharmacy, Ewha Womans University, Seoul 120-750, Korea.
authors.forename: Long Xuan
authors.initials: LX
authors.lastname: Zhao
authors.forename: Mikyung
authors.initials: M
authors.lastname: Yun
authors.forename: Hea Ok
authors.initials: HO
authors.lastname: Kim
authors.forename: Jeong A
authors.initials: JA
authors.lastname: Lee
authors.forename: Won Jun
authors.initials: WJ
authors.lastname: Choi
authors.forename: Kang Man
authors.initials: KM
authors.lastname: Lee
authors.forename: Sang Kook
authors.initials: SK
authors.lastname: Lee
authors.forename: Young B
authors.initials: YB
authors.lastname: Lee
authors.forename: Chang Ho
authors.initials: CH
authors.lastname: Ahn
authors.forename: Lak Shin
authors.initials: LS
authors.lastname: Jeong
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D003517:Cyclopentanes / Q000737:chemistry; D006801:Humans; D011741:Pyrimidine Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: C520191:4-amino-1-(1-fluoro-3,4-dihydroxy-2-hydroxymethylcyclohexen-5-yl)-2(1H)-pyrimidinone; D000970:Antineoplastic Agents; D003517:Cyclopentanes; D011741:Pyrimidine Nucleosides