title: Placebo-controlled double-blind clomipramine trial for the treatment of anxiety or fear in beagles during ground transport.
abstract: The purpose of this explorative study was, first, to document changes in physiological parameters and behavior observed in dogs following ground transport and, second, to measure the effects on the above variables of a short-term administration of clomipramine, anecdotally already prescribed in private veterinary practice to reduce fear, anxiety, or both. Twenty-four beagles were randomly allocated to either clomipramine (2 mg/kg, q12h for 7 d) or placebo treatment, and then transported 3 times in a truck for 1 hour. Physiological parameters (cortisol, neutrophil:lymphocyte (N:L) ratio, heart rate) and behavior were recorded and analyzed. Clomipramine significantly reduced plasma cortisol (P < 0.05) following transport and tended (P = 0.07) to reduce N:L ratio. Clomipramine tended to only reduce "moving and panting" and drooling. Short-term administration of clomipramine appears to slightly reduce fear, anxiety, or both during transport. More research is needed to confirm the efficacy of this treatment and the appropriate dosage.
authors.affiliation: Université de Montréal, Faculté de Médecine Vétéinaire, Centre Hospitalier, Universitaire Vétérinaire, C.P. 5000, Saint-Hyacinthe, Québec. diane.frank@umontreal.ca
authors.forename: Diane
authors.initials: D
authors.lastname: Frank
authors.forename: Audrey
authors.initials: A
authors.lastname: Gauthier
authors.forename: Renée
authors.initials: R
authors.lastname: Bergeron
mesh_terms: D000818:Animals; D014151:Anti-Anxiety Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001007:Anxiety / Q000097:blood / Q000188:drug therapy*; D001522:Behavior, Animal / Q000187:drug effects* / Q000502:physiology; D002997:Clomipramine / Q000009:adverse effects / Q000627:therapeutic use*; D004283:Dog Diseases / Q000097:blood / Q000188:drug therapy*; D004285:Dogs; D004311:Double-Blind Method; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology; D006854:Hydrocortisone / Q000097:blood; D018655:Lymphocyte Count / Q000662:veterinary; D008297:Male; D009504:Neutrophils / Q000378:metabolism; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects / Q000627:therapeutic use; D014186:Transportation; D016896:Treatment Outcome
chemical_list: D014151:Anti-Anxiety Agents; D002997:Clomipramine; D006854:Hydrocortisone; D017367:Selective Serotonin Reuptake Inhibitors