title: Mechanisms of nucleic acid translocases: lessons from structural biology and single-molecule biophysics.
abstract: Enzymes that translocate nucleic acids using ATP hydrolysis include DNA and RNA helicases, viral genome packaging motors and chromatin remodeling ATPases. Recent structural analysis, in conjunction with single-molecule studies, has revealed a wealth of new insights into how these enzymes use ATP-driven conformational changes to move on nucleic acids.
authors.affiliation: Gene Center, Feodor-Lynen-Strasse 25, D-81377 Munich, Germany. hopfner@lmb.uni-muenchen.de
authors.forename: Karl-Peter
authors.initials: KP
authors.lastname: Hopfner
authors.forename: Jens
authors.initials: J
authors.lastname: Michaelis
mesh_terms: D000251:Adenosine Triphosphatases / Q000737:chemistry / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000378:metabolism; D004265:DNA Helicases / Q000737:chemistry / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000737:chemistry / Q000378:metabolism; D009696:Nucleic Acids / Q000737:chemistry / Q000378:metabolism*; D011487:Protein Conformation; D020365:RNA Helicases / Q000737:chemistry / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins / Q000737:chemistry / Q000378:metabolism; D014157:Transcription Factors / Q000737:chemistry / Q000378:metabolism; D014166:Transferases / Q000737:chemistry* / Q000378:metabolism*
chemical_list: D004268:DNA-Binding Proteins; D009696:Nucleic Acids; D029701:Saccharomyces cerevisiae Proteins; D014157:Transcription Factors; D000255:Adenosine Triphosphate; D014166:Transferases; D000251:Adenosine Triphosphatases; C499333:SNF2 protein, S cerevisiae; D004265:DNA Helicases; D020365:RNA Helicases