title: Automated synthesis of 18F analogue of paclitaxel (PAC): [18F]Paclitaxel (FPAC).
abstract: A positron-emitting paclitaxel (PAC) derivative could allow in vivo measurement of multidrug resistance in tumors and, therefore, predict a potential chemotherapeutic benefit to patients. [18F]Paclitaxel was produced using a 2-reaction vessel automated synthesizer followed by HPLC purification. Optimized reaction conditions resulted in radiochemical yields of 21.2+/-9.6% at end of bombardment, radiochemical purity >99%, and specific activity of 159+/-43 G Bq/micromol. [18F]Paclitaxel activities of 1.33+/-0.729 G Bq (n=7) were obtained in sterile, pyrogen-free solution for IV administration.
authors.affiliation: Molecular Imaging Center, Department of Radiology, Virginia Commonwealth University, Richmond, VA, USA. jdkalen@vcu.edu
authors.forename: Joseph D
authors.initials: JD
authors.lastname: Kalen
authors.forename: Jerry I
authors.initials: JI
authors.lastname: Hirsch
authors.forename: Karen A
authors.initials: KA
authors.lastname: Kurdziel
authors.forename: William C
authors.initials: WC
authors.lastname: Eckelman
authors.forename: Dale O
authors.initials: DO
authors.lastname: Kiesewetter
mesh_terms: D001331:Automation; D019008:Drug Resistance, Neoplasm; D005462:Fluorine Radioisotopes / Q000737:chemistry*; D006801:Humans; D009369:Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy; D017239:Paclitaxel / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D011786:Quality Control; D011854:Radiochemistry / Q000295:instrumentation* / Q000592:standards; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000138:chemical synthesis*
chemical_list: D005462:Fluorine Radioisotopes; D019275:Radiopharmaceuticals; D017239:Paclitaxel