Phenotypic analysis of hepatic T lymphocytes in a dog with chronic hepatitis.
We evaluated hepatic T lymphocyte phenotypes in a dog with chronic hepatitis. Before treatment, numerous CD3+ lymphocytes were demonstrated in the liver, and the ratio of CD4+/CD8+ was remarkably high (2.96; reference range, 0.33+/-0.12). After treatment, CD3+ lymphocyte infiltration in the liver was reduced, and the ratio of CD4+/CD8+ decreased to 0.31. Therefore, hepatic T lymphocytes, especially CD4+ lymphocytes, might play a central role in the pathogenesis of this dog with chronic hepatitis.
Sakai
Manabu
M
Laboratory of Comprehensive Veterinary Clinical Studies, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, Kanagawa, Japan.
Otani
Isao
I
Ishigaki
Kumiko
K
Edamura
Kazuya
K
Takahashi
Tomoko
T
Koie
Hiroshi
H
Yamaya
Yoshiki
Y
Watari
Toshihiro
T
Shibuya
Hisashi
H
Sato
Tsuneo
T
Kanayama
Kiichi
K
Tokuriki
Mikihiko
M
Hasegawa
Atsuhiko
A
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000818:Animals; D004283:Dog Diseases / Q000188:drug therapy* / Q000276:immunology*; D004285:Dogs; D006521:Hepatitis, Chronic / Q000188:drug therapy / Q000276:immunology / Q000662:veterinary*; D016130:Immunophenotyping / Q000662:veterinary*; D008099:Liver / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
D000305:Adrenal Cortex Hormones