Instantaneous carbon-carbon bond formation using a microchannel reactor with a catalytic membrane.
Instantaneous catalytic carbon-carbon bond forming reactions were achieved in a microchannel reactor having a polymeric palladium complex membrane. The catalytic membrane was constructed inside the microchannel via self-assembling complexation at the interface between the organic and aqueous phases flowing laminarly, where non-cross-linked polymer-bound phosphine and ammonium tetrachloropalladate dissolved, respectively. A palladium-catalyzed coupling reaction of aryl halides and arylboronic acids was performed using the microchannel reactor to give quantitative yields of biaryls within 4 s of retention time in the defined channel region.
Uozumi
Yasuhiro
Y
Institute for Molecular Science (IMS) and the Graduate University for Advanced Studies, Higashi-yama 5-1, Myodaiji, Okazaki 444-8787, Japan. uo@ims.ac.jp
Yamada
Yoichi M A
YM
Beppu
Tomohiko
T
Fukuyama
Naoshi
N
Ueno
Masaharu
M
Kitamori
Takehiko
T