Synthesis and bioactivity of novel caffeic acid esters from Zuccagnia punctata.
Synthesis of novel caffeic acid esters (1 and 2) was accomplished starting from appropriately substituted benzaldehydes (3 and 9). While compound 2 exhibited potent anti-oxidative activity in both the nitroblue tetrazolium and 1,1-diphenyl-2-picrylhydrazyl radical-scavenging models, compound 1 showed moderate 5-lipoxygenase inhibitory activity.
Ramachandra
M S
MS
Laila Impex Research Centre, Unit 1, Phase III, Jawahar Autonagar, Vijayawada, 520 007, India.
Subbaraju
G V
GV
D000975:Antioxidants / Q000138:chemical synthesis* / Q000378:metabolism; D001547:Benzaldehydes / Q000737:chemistry; D001713:Biphenyl Compounds; D002109:Caffeic Acids / Q000138:chemical synthesis* / Q000737:chemistry; D004952:Esters / Q000138:chemical synthesis; D007887:Fabaceae / Q000737:chemistry*; D016859:Lipoxygenase Inhibitors; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009580:Nitroblue Tetrazolium; D010851:Picrates
C517905:1'-methyl-3'-(3,4-dihyrdoxyphenyl)-propyl caffeate; C517906:1'-methyl-3'-(4-hydroxyphenyl)propyl caffeate; D000975:Antioxidants; D001547:Benzaldehydes; D001713:Biphenyl Compounds; D002109:Caffeic Acids; D004952:Esters; D016859:Lipoxygenase Inhibitors; D010851:Picrates; D009580:Nitroblue Tetrazolium; C004931:1,1-diphenyl-2-picrylhydrazyl