[Studies on diterpenoids from Andrographis paniculata].
OBJECTIVE
To study the diterpenoids in the 85% ethanol extract of the aerial parts of Andrographis paniculata.


METHODS
Fourteen diterpenoids from the 85% EtOH extract were isolated by the silica gel, Sephadex LH-20, ODS column chromatography and HPLC, and their structures were identified by the spectal analyses and chemical evidences.


RESULTS
The 14 compounds were obtained and identified as neoandrographolide (1), 3, 14-di-deoxyandrographolide (2), andrographolide (3), 14-deoxy-11, 12-didehydroandrographolide (4), 19-hydroxy-8 (17), 13-labdadien-15, 16-olide (5), 14-deoxy-andrographolide (6), 3-oxo-14-deoxy-andrographolide (7), isoandrographolide, (8), bisandrographolide (9, 10, 11), deoxyandrographiside (12), 14-deoxy-11, 12-didehydroandrographiside (13), andrographiside (14), respectively.


CONCLUSIONS
Compound 7 was a new natural product, and compound 5 was obtained for the first time from the Andrographis species.
Chen
Li-Xia
LX
Department of Natural Products Chemistry, Shenyang Pharmaceutical University, Shenyang 110016, China.
Qu
Ge-Xia
GX
Qiu
Feng
F
D035685:Andrographis / Q000737:chemistry*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification*; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification; D015394:Molecular Structure; D035261:Plant Components, Aerial / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D013764:Tetrahydronaphthalenes / Q000737:chemistry / Q000302:isolation & purification
C523880:19-hydroxy-8(17),13-labdadien-15,16-olide; C523879:3-oxo-14-deoxyandrographolide; D004224:Diterpenes; D005960:Glucosides; D013764:Tetrahydronaphthalenes; C030419:andrographolide; C082497:neoandrographolide