title: Relationship of low-density lipoprotein particle size to insulin resistance and intima-media thickness in nondiabetic Koreans.
abstract: The aim of this study was to investigate whether low-density lipoprotein (LDL) particle size is associated with insulin resistance and to explore the association between LDL particle size and preclinical atherosclerosis in nondiabetic Korean population. We measured the carotid intima-media thickness (IMT), LDL particle size, and insulin resistance in 136 nondiabetic subjects. Low-density lipoprotein particle size was significantly correlated with insulin resistance, but the independent risk factors of LDL particle size determined by the multiple regression analysis were age, triglyceride, and high-density lipoprotein cholesterol (HDL-C). Carotid IMT was associated with traditional risk factors of atherosclerosis, which are age, HDL-C, LDL cholesterol, systolic and diastolic blood pressure, but LDL particle size was not correlated with carotid IMT. We conclude that LDL particle size was associated with insulin resistance, but age, triglyceride, and HDL-C contributed independently to the variability in LDL particle size, and LDL particle size was not a predictor of preclinical atherosclerosis in nondiabetic Koreans.
authors.affiliation: Department of Internal Medicine, College of Medicine, Yonsei University, Seoul, South Korea.
authors.forename: Jong Suk
authors.initials: JS
authors.lastname: Park
authors.forename: Jina
authors.initials: J
authors.lastname: Park
authors.forename: Chul Sik
authors.initials: CS
authors.lastname: Kim
authors.forename: Min Ho
authors.initials: MH
authors.lastname: Cho
authors.forename: Hai Jin
authors.initials: HJ
authors.lastname: Kim
authors.forename: Jeong-Ho
authors.initials: JH
authors.lastname: Kim
authors.forename: Chul Woo
authors.initials: CW
authors.lastname: Ahn
authors.forename: Kyung Rae
authors.initials: KR
authors.lastname: Kim
authors.forename: Bong Soo
authors.initials: BS
authors.lastname: Cha
authors.forename: Sung Kil
authors.initials: SK
authors.lastname: Lim
authors.forename: Hyun Chul
authors.initials: HC
authors.lastname: Lee
mesh_terms: D000328:Adult; D000368:Aged; D050197:Atherosclerosis / Q000209:etiology*; D002339:Carotid Arteries / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D008077:Lipoproteins, LDL / Q000737:chemistry*; D008079:Lipoproteins, VLDL / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010316:Particle Size; D012044:Regression Analysis; D017539:Tunica Intima / Q000473:pathology*; D017540:Tunica Media / Q000473:pathology*; D014463:Ultrasonography
chemical_list: D008077:Lipoproteins, LDL; D008079:Lipoproteins, VLDL