Surfaces of fluorinated pyridinium block copolymers with enhanced antibacterial activity.
Polystyrene-b-poly(4-vinylpyridine) copolymers were quaternized with 1-bromohexane and 6-perfluorooctyl-1-bromohexane. Surfaces prepared from these polymers were characterized by contact angle measurements, near-edge X-ray absorption fine structure spectroscopy and X-ray photoelectron spectroscopy. The fluorinated pyridinium surfaces showed enhanced antibacterial activity compared to their nonfluorinated counterparts. Even a polymer with a relatively low molecular weight pyridinium block showed high antimicrobial activity. The bactericidal effect was found to be related to the molecular composition and organization in the top 2-3 nm of the surface and increased with increasing hydrophilicity and pyridinium concentration of the surface.
Krishnan
Sitaraman
S
Department of Materials Science and Engineering, Cornell University, Ithaca, NY 14853, USA.
Ward
Rebekah J
RJ
Hexemer
Alexander
A
Sohn
Karen E
KE
Lee
Kristen L
KL
Angert
Esther R
ER
Fischer
Daniel A
DA
Kramer
Edward J
EJ
Ober
Christopher K
CK
D000900:Anti-Bacterial Agents / Q000737:chemistry*; D004926:Escherichia coli / Q000254:growth & development*; D005466:Fluorocarbons / Q000737:chemistry*; D006846:Hydrocarbons, Halogenated / Q000737:chemistry*; D011137:Polystyrenes / Q000737:chemistry*; D011145:Polyvinyls / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry*; D013052:Spectrometry, X-Ray Emission / Q000379:methods; D013211:Staphylococcus aureus; D013499:Surface Properties
D000900:Anti-Bacterial Agents; D005466:Fluorocarbons; D006846:Hydrocarbons, Halogenated; D011137:Polystyrenes; D011145:Polyvinyls; D011725:Pyridines; C509607:polystyrene-block-poly(4-vinylpyridine); C118701:1-bromohexane