title: Confirmation of Chagas' cardiomyopathy following heart transplantation.
abstract: We report a case of Chagas' cardiomyopathy confirmed in a patient after heart transplantation. The patient initially presented with symptoms of congestive heart failure and was found to have positive serology for prior Trypanosoma cruzi infection. Despite optimal medical management, the patient had deterioration of his cardiac function and he underwent heart transplantation. Pathology examination of the explanted heart confirmed Chagas' cardiomyopathy. The cardiac sequelae of Chagas' disease include arrhythmias, aneurysm, thromboembolism, cardiomyopathy, and sudden death. We review the epidemiology, cardiac pathology, and evaluation of patients with Chagas' cardiac disease. We discuss the clinical features of Chagas' cardiomyopathy and available treatments including cardiac transplantation.
authors.affiliation: Division of Cardiology, Department of Medicine, University of Washington, 1914 N 34th Street, Suite 105, Seattle, WA 98103, USA. bapp@u.washington.edu
authors.forename: Binh An P
authors.initials: BA
authors.lastname: Phan
authors.forename: Michael A
authors.initials: MA
authors.lastname: Laflamme
authors.forename: April
authors.initials: A
authors.lastname: Stempien-Otero
authors.forename: Ajit P
authors.initials: AP
authors.lastname: Limaye
authors.forename: Frederick S
authors.initials: FS
authors.lastname: Buckner
authors.forename: Wayne C
authors.initials: WC
authors.lastname: Levy
mesh_terms: D000818:Animals; D002598:Chagas Cardiomyopathy / Q000469:parasitology / Q000473:pathology*; D018450:Disease Progression; D006333:Heart Failure / Q000469:parasitology* / Q000601:surgery; D016027:Heart Transplantation; D006801:Humans; D008297:Male; D008875:Middle Aged; D014349:Trypanosoma cruzi / Q000276:immunology