[Cardiomyocyte culture as a highly sensitive system for testing pharmacological activity of specific bradycardic agents].
Two antiarrhythmic agents were studied: verapamil and bradizole, a new bradycardic drug. It was found that both drugs exhibit a dose-dependent negative chronotropic effect on the culture of contractile cardiomyocytes of newborn rats. Bradizole showed more pronounced bradycardic properties than verapamil.
Neverova
M E
ME
Mkrtumova
N A
NA
Fidelina
O V
OV
Adamskaia
E I
EI
Tsorin
I B
IB
Chichkanov
G G
GG
Chudakov
L I
LI
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology*; D001562:Benzimidazoles / Q000494:pharmacology*; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D002478:Cells, Cultured; D009200:Myocardial Contraction; D032383:Myocytes, Cardiac / Q000187:drug effects*; D051381:Rats; D013438:Sulfhydryl Compounds / Q000494:pharmacology*; D014700:Verapamil / Q000494:pharmacology*
C111159:2-(2-(diethylamino)ethyl)thio-5-ethoxybenzimidazole; D000889:Anti-Arrhythmia Agents; D001562:Benzimidazoles; D002121:Calcium Channel Blockers; D013438:Sulfhydryl Compounds; D014700:Verapamil