[IFN-gamma and TGF-beta1, levels in the expressed prostatic secretions of patients with chronic abacterial prostatitis].
OBJECTIVE
To investigate the levels of pro-inflammatory cytokine IFN-gamma and anti-inflammatory cytokine TGF-beta1, in the expressed prostatic secretion (EPS) of men with chronic abacterial prostatitis and their clinical significance.


METHODS
The levels of IFN-gamma and TGF-beta1, in the EPS of 20 patients with inflammatory chronic pelvic pain syndrome (type III A), 20 patients with non-inflammatory chronic pelvic pain syndrome (type Ill B) and 10 healthy men were measured using enzyme-linked immunosorbent assay (ELISA). The results were analysed comparatively with NIH-chronic prostatitis symptom index (NIH-CPSI).


RESULTS
IFN--gamma and TGF-beta1 levels were higher in III ([14.92 +/- 7. 85)], [8477.50 +/- 4612.45] ng/L) and III B ([13.74 +/- 5.96], [7946.50 +/- 5044.06] ng/L) prostatitis patients than those in the controls ([7.47 +/- 1.49], [2462.50 +/- 985.31] ng/L), P < 0.05 and P < 0.001 respectively. There was no statistically significant difference in cytokine levels between III A and Il B prostatitis patients. No correlation was found between NIH-CPSI and cytokine levels, r = 0.02, P = 0.86, r = 0.31, P = 0.76.


CONCLUSIONS
IFN-gamma and TGF-beta1, play a very important role in the etiology of chronic abacterial prostatitis and can be the objective parameters in the diagnosis of chronic abacterial prostatitis.
Ding
Xie-gang
XG
Department of Urology, Zhongnan Hospital, Wuhan University, Wuhan, Hubei 430071, China. dxg1014_0_0@sohu.com
Li
Shi-wen
SW
Zheng
Xin-min
XM
Hu
Li-quan
LQ
D000328:Adult; D012634:Bodily Secretions / Q000737:chemistry; D002908:Chronic Disease; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007371:Interferon-gamma / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D017699:Pelvic Pain / Q000175:diagnosis; D011467:Prostate / Q000378:metabolism*; D011472:Prostatitis / Q000175:diagnosis*; D053773:Transforming Growth Factor beta1 / Q000032:analysis*
D053773:Transforming Growth Factor beta1; D007371:Interferon-gamma