title: Recurrent optic disc and retinal vasculitis in a patient with drug-induced urticarial vasculitis.
abstract: The purpose of this study was to report recurrent optic disc and retinal vasculitis in a patient with drug-induced urticarial vasculitis. Complete ophthalmological examination including fluorescein angiography and visual field examination were done. A 53-year-old woman with recurrent painful urticarial skin lesions following trimethoprim sulfamethoxazole usage had the clinical and histopathological diagnosis of urticarial vasculitis. Two years after cutaneous manifestations, she began to notice visual disturbances in both eyes that recurred at 1-year intervals. Her ophthalmological findings were consistent with recurrent vasculitis of the optic nerve and retina. Treatment with high-dose corticosteroids and hydroxychloroquine resulted in the resolution of cutaneous and ocular manifestations. This patient demonstrates that recurrent occlusive vasculitis of the optic nerve and retina can occur in this rare disease. These patients should be examined periodically by ophthalmologists.
authors.affiliation: Department of Ophthalmology, Faculty of Medicine, Ankara University, Ankara, Turkey. fbatioglu@hotmail.com
authors.forename: Figen
authors.initials: F
authors.lastname: Batioğlu
authors.forename: Pelin
authors.initials: P
authors.lastname: Taner
authors.forename: Olcay Tiryaki
authors.initials: OT
authors.lastname: Aydintuğ
authors.forename: Aylin Okçu
authors.initials: AO
authors.lastname: Heper
authors.forename: Emin
authors.initials: E
authors.lastname: Ozmert
mesh_terms: D000890:Anti-Infective Agents / Q000009:adverse effects*; D003879:Dermatologic Agents / Q000627:therapeutic use; D004345:Drug Industry; D004359:Drug Therapy, Combination; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D006886:Hydroxychloroquine / Q000627:therapeutic use; D008775:Methylprednisolone / Q000627:therapeutic use; D008875:Middle Aged; D009898:Optic Disk / Q000098:blood supply*; D020551:Pulse Therapy, Drug; D012008:Recurrence; D031300:Retinal Vasculitis / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy; D016896:Treatment Outcome; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000009:adverse effects*; D014581:Urticaria / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy; D018366:Vasculitis, Leukocytoclastic, Cutaneous / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy
chemical_list: D000890:Anti-Infective Agents; D003879:Dermatologic Agents; D005938:Glucocorticoids; D006886:Hydroxychloroquine; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D008775:Methylprednisolone