title: Relevance of MICA antibodies in acute humoral rejection in renal transplant patients.
abstract: The presence of MICA antibodies was examined in eleven patients diagnosed with AHR. MICA typing was performed in both recipients and donors. Sera were collected sequentially: pre-transplant, at the AHR episode and at follow-up. Sera from 30 patients with functioning graft were also analysed. A stable MICA()008 transfected cell line was used as target to identify MICA antibodies. MICA antibodies were not detected pre-transplant nor post-transplant in patients receiving a compatible graft. MICA antibodies were detected post-transplant AHR in patients receiving an incompatible graft. The persistence of MICA antibodies was associated with chronic graft dysfunction in 3 of 4 patients in this series; although it was not always associated with the graft loss in treated AHR. None of the 30 patients in the control group with long-term functioning grafts showed antibodies to MICA()008. This report provides some insights of the relevance of MICA antibodies in AHR.
authors.affiliation: Immunology Service, Hospital Clinic Barcelona, IDIBAPS, Villarroel 170, Barcelona, Spain.
authors.forename: Núria
authors.initials: N
authors.lastname: Amézaga
authors.forename: M
authors.initials: M
authors.lastname: Crespo
authors.forename: M
authors.initials: M
authors.lastname: Lopez-Cobos
authors.forename: M A
authors.initials: MA
authors.lastname: Millán
authors.forename: O
authors.initials: O
authors.lastname: Viñas
authors.forename: M
authors.initials: M
authors.lastname: Solé
authors.forename: F
authors.initials: F
authors.lastname: Oppenheimer
authors.forename: J
authors.initials: J
authors.lastname: Martorell
authors.forename: M G
authors.initials: MG
authors.lastname: Ercilla
mesh_terms: D000208:Acute Disease; D002460:Cell Line; D002908:Chronic Disease; D006084:Graft Rejection / Q000209:etiology* / Q000276:immunology*; D015395:Histocompatibility Antigens Class I / Q000235:genetics; D006801:Humans; D007518:Isoantibodies / Q000097:blood*; D016030:Kidney Transplantation / Q000009:adverse effects* / Q000276:immunology*; D011446:Prospective Studies; D011994:Recombinant Proteins / Q000235:genetics / Q000276:immunology; D014162:Transfection
chemical_list: D015395:Histocompatibility Antigens Class I; D007518:Isoantibodies; C099187:MHC class I-related chain A; D011994:Recombinant Proteins