Can ageing be prevented by dietary restriction?
This paper disputes the suggestion of Hipkiss [Hipkiss, A., 2006. On the mechanisms of ageing suppression by dietary restriction-is persistent glycolysis the problem? Mech. Ageing Dev. 127, 8-15], according to which dietary restriction by decreasing methylglyoxal production may prevent ageing. A list of arguments is given to support the refusal of hypothesis: (i) it has never been proven that the main source of methylglyoxal is its formation from triose-phosphate intermediates of glycolysis; (ii) the above note particularly applies to pathological conditions as acetone breakdown and amino acid metabolism also come into picture under these circumstances; (iii) glycolysis is of vital importance, thus its inhibition or a sharp restriction of carbohydrate uptake are unlikely beneficial for those tissues that are exclusively dependent on glycolysis in the regard of their energy production. Taken these concerns into account and considered all the promising attempts to influence the toxic effects of methylglyoxal, it is feared that the theory, as it is, cannot offer benefit to prevent ageing.
Kalapos
Miklós Péter
MP
Theoretical Biology Research Group, Dámvad utca 18, H-1029 Budapest, Hungary. MKalapos@Freestart.Hu
D000096:Acetone / Q000031:analogs & derivatives / Q000378:metabolism; D000105:Acetyl Coenzyme A / Q000378:metabolism; D000375:Aging / Q000502:physiology*; D000449:Aldehyde Reductase / Q000378:metabolism; D000818:Animals; D031204:Caloric Restriction; D019392:Cytochrome P-450 CYP2E1 / Q000378:metabolism; D006019:Glycolysis; D006801:Humans; D011765:Pyruvaldehyde / Q000378:metabolism*
D000096:Acetone; D000105:Acetyl Coenzyme A; D011765:Pyruvaldehyde; D000449:Aldehyde Reductase; D019392:Cytochrome P-450 CYP2E1; C006495:aminoacetone