RegTransBase--a database of regulatory sequences and interactions in a wide range of prokaryotic genomes.
RegTransBase is a manually curated database of regulatory interactions in prokaryotes that captures the knowledge in public scientific literature using a controlled vocabulary. Although several databases describing interactions between regulatory proteins and their binding sites are already being maintained, they either focus mostly on the model organisms Escherichia coli and Bacillus subtilis or are entirely computationally derived. RegTransBase describes a large number of regulatory interactions reported in many organisms and contains the following types of experimental data: the activation or repression of transcription by an identified direct regulator, determining the transcriptional regulatory function of a protein (or RNA) directly binding to DNA (RNA), mapping or prediction of a binding site for a regulatory protein and characterization of regulatory mutations. Currently, RegTransBase content is derived from about 3000 relevant articles describing over 7000 experiments in relation to 128 microbes. It contains data on the regulation of about 7500 genes and evidence for 6500 interactions with 650 regulators. RegTransBase also contains manually created position weight matrices (PWM) that can be used to identify candidate regulatory sites in over 60 species. RegTransBase is available at http://regtransbase.lbl.gov.
Kazakov
Alexei E
AE
Institute for Information Transmission Problems, RAS. Bolshoi Karetny pereulok 19, Moscow, 127994, Russia.
Cipriano
Michael J
MJ
Novichkov
Pavel S
PS
Minovitsky
Simon
S
Vinogradov
Dmitry V
DV
Arkin
Adam
A
Mironov
Andrey A
AA
Gelfand
Mikhail S
MS
Dubchak
Inna
I
D001426:Bacterial Proteins / Q000378:metabolism*; D001665:Binding Sites; D030561:Databases, Nucleic Acid; D015964:Gene Expression Regulation, Bacterial; D016680:Genome, Bacterial; D020407:Internet; D050436:Regulatory Elements, Transcriptional; D014157:Transcription Factors / Q000378:metabolism*; D014584:User-Computer Interface
D001426:Bacterial Proteins; D014157:Transcription Factors