Control of DNA hybridization by photoswitchable mismatch binding ligands.
We herein demonstrate that mismatch binding ligands (MBL) can function as a molecular glue which brings two single stranded DNA (ssDNA) together to form the double stranded DNA (dsDNA). Incorporation of a photoisomerizable azobenzene linkage provides further ability of reversibly controlling duplex stability with light.
Dohno
Chikara
C
The Institute of Scientific and Industrial Research, Osaka University, 8-1 Mihogaoka, Ibaraki 567-0047, Japan.
Uno
Shin-nosuke
SN
Nakatani
Kazuhiko
K
D001391:Azo Compounds / Q000737:chemistry* / Q000528:radiation effects*; D020137:Base Pair Mismatch; D004247:DNA / Q000737:chemistry*; D004277:DNA, Single-Stranded / Q000737:chemistry; D006860:Hydrogen Bonding; D007536:Isomerism; D008024:Ligands; D008958:Models, Molecular; D009287:Naphthyridines / Q000737:chemistry* / Q000528:radiation effects*; D009693:Nucleic Acid Hybridization; D010777:Photochemistry; D013696:Temperature
C522081:4,4'-bis(3-(7-methylnaphthyridin-2-ylcarbamoyloxy)propylaminomethyl)azobenzene; D001391:Azo Compounds; D004277:DNA, Single-Stranded; D008024:Ligands; D009287:Naphthyridines; D004247:DNA