title: Mucormycosis mimicks sinusitis in a diabetic adult.
abstract: Fungal sinusitis caused by invasive fungal infections, such as Mucormycosis, occurs predominantly in an immunocompromised patient. However, invasive cranial bone mycoses are rare and are usually associated with host immunodeficiency. They are difficult to diagnose, and in many cases are fatal. Treatment consists of antifungal chemotherapy, radical surgical debridement, and control of the underlying immunological condition. We report a case of Mucormycosis in a patient with type 1 diabetes mellitus. The patient had a history of dental pathology and associated renal dysfunction. The patient was managed by extensive surgical debridement followed by amphotericin B lipid complex injection (Abelcet 5 mg/bw kg/day) as an antifungal agent. Our patient's ocular function was affected. The radical treatment and follow-up by a multidisciplinary team eliminated the mucor-related consequences, however, the patient died because of end-stage renal failure. In conclusion, type 1 diabetes may be associated with invasive fungal sinusitis.
authors.affiliation: National Medical Center, Department of ENT, Szabolcs utca 35. 1135-Budapest, Hungary. szalaigy@ogyik.hu
authors.forename: György
authors.initials: G
authors.lastname: Szalai
authors.forename: Veronika
authors.initials: V
authors.lastname: Fellegi
authors.forename: Zsuzsanna
authors.initials: Z
authors.lastname: Szabó
authors.forename: Lajos Csokonai
authors.initials: LC
authors.lastname: Vitéz
mesh_terms: D000328:Adult; D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D003922:Diabetes Mellitus, Type 1 / Q000150:complications*; D003928:Diabetic Nephropathies; D003937:Diagnosis, Differential; D006801:Humans; D008297:Male; D009091:Mucormycosis / Q000175:diagnosis* / Q000188:drug therapy; D012852:Sinusitis / Q000175:diagnosis* / Q000000981:diagnostic imaging; D014057:Tomography, X-Ray Computed
chemical_list: D000935:Antifungal Agents; D000666:Amphotericin B