title: Reconstruction of fetal cardiac vectors from multichannel fMCG data using recursively applied and projected multiple signal classification.
abstract: Previous attempts at unequivocal specification of signal strength in fetal magnetocardiographic (fMCG) recordings have used an equivalent current dipole (ECD) to estimate the cardiac vector at the peak of the averaged QRS complex. However, even though the magnitude of fetal cardiac currents are anticipated to be relatively stable, ECD-based estimates of signal strength show substantial and unrealistic variation when comparing results from different time windows of the same recording session. The present study highlights the limitations of the ECD model, and proposes a new methodology for fetal cardiac source reconstruction. The proposed strategy relies on recursive subspace projections to estimate multiple dipoles that account for the distributed myocardial currents. The dipoles are reconstructed from spatio-temporal fMCG data, and are subsequently used to derive estimators of the cardiac vector over the entire QRS. The new method is evaluated with respect to simulated data derived from a model of ventricular depolarization, which was designed to account for the complexity of the fetal cardiac source configuration on the QRS interval. The results show that the present methodology overcomes the drawbacks of conventional ECD fitting, by providing robust estimators of the cardiac vector. Additional evaluation with real fMCG data show fetal cardiac vectors whose morphology closely resembles that obtained in adult MCG.
authors.affiliation: Hoglund Brain Imaging Center, The University of Kansas Medical Center, Kansas City, KS 66103, USA. mpopescu@kumc.edu
authors.forename: Mihai
authors.initials: M
authors.lastname: Popescu
authors.forename: Elena-Anda
authors.initials: EA
authors.lastname: Popescu
authors.forename: Kathleen
authors.initials: K
authors.lastname: Fitzgerald-Gustafson
authors.forename: William B
authors.initials: WB
authors.lastname: Drake
authors.forename: Jeffrey D
authors.initials: JD
authors.lastname: Lewine
mesh_terms: D000465:Algorithms; D015148:Cardiotocography / Q000379:methods*; D003198:Computer Simulation; D003936:Diagnosis, Computer-Assisted / Q000379:methods*; D006801:Humans; D053798:Magnetocardiography / Q000379:methods*; D008955:Models, Cardiovascular; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014672:Vectorcardiography / Q000379:methods*