[The effect of nuclear factor-kappaB protein expression in spiral ganglion cells of cochlea by overdosage sodium salicylate injection in guinea pigs].
OBJECTIVE
To study the effect of sodium salicylate on the nuclear factor-kappaB (NF-kappaB) protein expression in spiral ganglion cells.


METHODS
Forty-eight healthy guinea pigs were randomly divided into four groups: group A: the control group (0.9% sodium chloride); group B: sodium salicylate [450 mg/(kg x d)] group; group C: sodium salicylate [450 mg/(kg x d)]+chlorpromazine [5 mg/(kg x d)] group; group D: sodium salicylate [450 mg/(kg x d)] +nimodipine [3 mg/(kg x d)] group. The protein expression level of NF-kappaB was examined by immunohistochemical method.


RESULTS
The protein expression of NF-kappaB in spiral ganglion cells of group B was significantly higher than that of other groups.


CONCLUSIONS
Sodium salicylate can promote the protein expression of NF-kappaB in cochlear spiral ganglion cells. Nimodipine and chloropazine can weaken the protein expression of NF-kappaB, which is caused by sodium salicylate in cochlear spiral ganglion cells.
Lü
Hong
H
Department of Otolaryngology, First Affiliated Hospital of Xianning Medical College, Xianning 437100, China.
Wu
Lilian
L
Zeng
Ying
Y
D000818:Animals; D054644:Ear Auricle; D006168:Guinea Pigs; D016328:NF-kappa B / Q000378:metabolism*; D012980:Sodium Salicylate / Q000494:pharmacology*; D013136:Spiral Ganglion / Q000187:drug effects* / Q000378:metabolism*
D016328:NF-kappa B; D012980:Sodium Salicylate