title: Comparison of fibrinolytic and metabolic system parameters in obese patients with polycystic ovary syndrome and women with simple obesity.
abstract: The present study aimed to assess the fibrinolytic and metabolic system parameters in obese patients with polycystic ovary syndrome (PCOS) and to compare them in obese PCOS patients and women with simple obesity. We studied 19 obese women with PCOS (age: 25.1 +/- 4.6 years, body mass index (BMI): 34.7 +/- 3.9 kg/m2; mean +/- standard deviation) and 20 age- and BMI-matched ovulatory controls. We measured blood levels of 17beta-estradiol, testosterone, prolactin, luteinizing hormone (LH), follicle-stimulating hormone (FSH), dehydroepiandrosterone sulfate (DHEAS), total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), glucose and insulin. The following fibrinolytic tests were also performed: euglobulin clot lysis time, plasminogen level, alpha2-antiplasmin activity, plasminogen activator inhibitor-1 activity, fibrinogen concentration and estimated fibrinolytic activity. Testosterone and LH levels were significantly higher in obese women with PCOS (p < 0.01 and p < 0.001, respectively). The groups did not differ with regard to 17beta-estradiol, prolactin, FSH, DHEAS, TC, TG, HDL-C, LDL-C, glucose and insulin. All of the fibrinolysis parameters with the exception of plasminogen were comparable between the two groups. Serum plasminogen level was lower in obese PCOS patients than in women with simple obesity (p < 0.05). Euglobulin clot lysis time was positively correlated with insulin (r = 0.88, p < 0.05) in both groups. Our results show that fibrinolysis is not suppressed in women with PCOS and that there is no difference in fibrinolytic activity between obese patients with PCOS and women with simple obesity.
authors.affiliation: Department of Gynecological Endocrinology, University of Medical Sciences of Poznań, Poznań, Poland.
authors.forename: R
authors.initials: R
authors.lastname: Słopień
authors.forename: K
authors.initials: K
authors.lastname: Lewandowski
authors.forename: E
authors.initials: E
authors.lastname: Kolacz
authors.forename: K
authors.initials: K
authors.lastname: Zawilska
authors.forename: A
authors.initials: A
authors.lastname: Warenik-Szymankiewicz
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D016022:Case-Control Studies; D002784:Cholesterol / Q000097:blood; D003687:Dehydroepiandrosterone / Q000097:blood; D004958:Estradiol / Q000097:blood; D005260:Female; D005342:Fibrinolysis; D005343:Fibrinolytic Agents / Q000097:blood*; D006065:Gonadotropins, Pituitary / Q000097:blood; D006801:Humans; D007328:Insulin / Q000097:blood; D009765:Obesity / Q000097:blood*; D011085:Polycystic Ovary Syndrome / Q000097:blood*; D013739:Testosterone / Q000097:blood
chemical_list: D001786:Blood Glucose; D005343:Fibrinolytic Agents; D006065:Gonadotropins, Pituitary; D007328:Insulin; D013739:Testosterone; D003687:Dehydroepiandrosterone; D004958:Estradiol; D002784:Cholesterol