title: Primary cutaneous marginal zone B-cell lymphoma of MALT type in a child.
abstract: Marginal zone B-cell lymphoma (MZBCL) of mucosa-associated lymphoid tissue type is a peculiar variant of B-cell neoplasm showing distinct clinical and pathologic features. Its occurrence in children or adolescents is extremely uncommon. We describe the case of an 11-year-old boy who developed such a lymphomatous process involving primarily the skin. The tumor was characterized by a maturing plasma cell population that included immunoblasts, heavy-chain but not light-chain restriction suggestive of monoclonality, and a prevalent, focally granulomatous component of histiocytes. As an additional interesting feature, a trisomy 3 was demonstrated by fluorescence in situ hybridization analysis. The clinical, morphological, phenotypic, and genetic characteristics seen in our patient do not differ significantly from those described in primary cutaneous MZBCL occurring in adults.
authors.affiliation: Department of Anatomic Pathology, Centre Hospitalier Universitaire Saint-Pierre/Institut Jules Bordet, Institut Jules Bordet, 1 rue Héger-Bordet, 1000 Brussels, Belgium. jl.dargent@skynet.be
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Dargent
authors.forename: Christine
authors.initials: C
authors.lastname: Devalck
authors.forename: Albert
authors.initials: A
authors.lastname: De Mey
authors.forename: Eric
authors.initials: E
authors.lastname: Vandeweyer
authors.forename: Laurence
authors.initials: L
authors.lastname: Lespagnard
authors.forename: Pierre
authors.initials: P
authors.lastname: Heimann
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D002648:Child; D002893:Chromosomes, Human, Pair 3; D018572:Disease-Free Survival; D006644:Histiocytes / Q000737:chemistry / Q000473:pathology; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D018442:Lymphoma, B-Cell, Marginal Zone / Q000235:genetics / Q000473:pathology* / Q000601:surgery; D008297:Male; D010950:Plasma Cells / Q000737:chemistry / Q000473:pathology; D012878:Skin Neoplasms / Q000235:genetics / Q000473:pathology* / Q000601:surgery; D014314:Trisomy
chemical_list: D014408:Biomarkers, Tumor