title: Anterior skull base surgery for secondary malignancies in retinoblastoma survivors: report of two cases.
abstract: With the improved survival rate of patients with retinoblastoma, the incidence of second malignancies has become substantial. We had two retinoblastoma survivors with secondary malignancies in the naso-ethmoidal complex, one a 21-year-old man with anaplastic carcinoma and the other a 16-year-old girl with malignant fibrous histiocytoma. They underwent repeated craniofacial surgery. Secondary malignancies arising at the nose and ethmoidal cells often invade the anterior skull base. The introduction of skull base surgery has provided wider surgical margins and increased the resultant likelihood of cure. Both patients have so far shown no evidence of recurrence.
authors.forename: K
authors.initials: K
authors.lastname: Ichimura
authors.forename: K
authors.initials: K
authors.lastname: Nibu
authors.forename: T
authors.initials: T
authors.lastname: Tanaka
authors.forename: H
authors.initials: H
authors.lastname: Takekoshi
authors.forename: T
authors.initials: T
authors.lastname: Sasaki
authors.forename: M
authors.initials: M
authors.lastname: Taniguchi
authors.forename: T
authors.initials: T
authors.lastname: Nakatsuka