Taurine transport and transporter localization in peripheral blood lymphocytes of controls and major depression patients.
Taurine concentration is increased in peripheral blood lymphocytes in a group of depressed subjects. After this observation [3H]taurine transport was measured in lymphocytes of 10 major depression patients (19-60 years old), diagnosed by the criteria of the American Psychiatric Association, with moderate severity as determined by Hamilton Scale for Depression (32 +/- 6). The control group comprised 10 subjects (20-56 years old). Taurine transporter and CD4+ (helpers) and CD8+ (cytolytic) T lymphocytes were immunolabeled. No significant differences were observed in immunochemical analyses. CD4+ cells were 53% and CD8+ cells 28% of the total lymphocytes in both controls and patients. Two taurine transport components, high and low affinity, were demonstrated in both groups. Taurine transporter was present in 16% of CD4+ and CD8+ lymphocytes in controls and patients. This preliminary report exhibits the presence of taurine transporter in peripheral blood lymphocytes but no differences were observed between controls and depressed subjects.
Fazzino
Fili
F
Laboratorio de Neuroquímica, Centro de Biofísica y Bioquímica, Instituto Venezolano de Investigaciones Científicas, Caracas, Venezuela.
Urbina
Mary
M
Mata
Salvador
S
Lima
Lucimey
L
D000293:Adolescent; D000328:Adult; D003865:Major Depressive Disorder / Q000097:blood* / Q000175:diagnosis; D006801:Humans; D008214:Lymphocytes / Q000166:cytology / Q000378:metabolism*; D008562:Membrane Glycoproteins / Q000097:blood*; D026901:Membrane Transport Proteins / Q000097:blood*; D008875:Middle Aged; D013654:Taurine / Q000378:metabolism*; D000099247:Taurine Transporters
D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D013654:Taurine; D000099247:Taurine Transporters