title: [Breast-conserving therapy for centrally located primary breast cancer].
abstract: OBJECTIVE
  The goal of the study is to investigate the feasibility of breast-conserving therapy for early primary breast carcinoma centrally located in the breast.
  
  
  METHODS
  157 patients with stage I or II primary breast cancer located in the central part of the breast were operated with extended local excision and axillary lymph node dissection. Nipple-areola complex was excised in 18 patients. Ninety-three patients received two to six cycles neo-adjuvant chemotherapy. Radiotherapy was given postoperatively to the whole remaining breast.
  
  
  RESULTS
  The clinical response rate was 87.1% (81/93) and pathologic complete remission rate was 15.1% (14/93) after neo-adjuvant chemotherapy. Breast conservation surgery was performed successfully for all the patients in this series. After a median follow-up of 23 months (range 6-53 months), there was no recurrence in the ipsilateral breast. The aesthetic effect of the conserved breast was satisfactory including excellent for 88 patients and good for 48 patients representing of 86.6% of all cases.
  
  
  CONCLUSIONS
  Breast conserving surgery is suitable for the early centrally located primary breast carcinoma. Though the short-term results are satisfactory, the long-term follow-up is still needed for the final outcome.
authors.affiliation: Breast Cancer Center, Peking Cancer Institute (Hospital), School of Oncology, Peking University, Beijing 100036, China. jinfeng_li@hotmail.com
authors.forename: Jin-Feng
authors.initials: JF
authors.lastname: Li
authors.forename: Tao
authors.initials: T
authors.lastname: Ouyang
authors.forename: Tian-Feng
authors.initials: TF
authors.lastname: Wang
authors.forename: Yun-Tao
authors.initials: YT
authors.lastname: Xie
authors.forename: Zhao-Qing
authors.initials: ZQ
authors.lastname: Fan
authors.forename: Ben-Yao
authors.initials: BY
authors.lastname: Lin
mesh_terms: D000328:Adult; D000368:Aged; D001365:Axilla; D001943:Breast Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery*; D018270:Carcinoma, Ductal, Breast / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery*; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D005240:Feasibility Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008197:Lymph Node Excision; D008207:Lymphatic Metastasis; D015412:Mastectomy, Segmental / Q000379:methods*; D008875:Middle Aged; D012074:Remission Induction; D016896:Treatment Outcome