title: Breach delivery: increased solute uptake points to a defective skin barrier in atopic dermatitis.
abstract: Evidence is now emerging for enhanced penetration of chemical solutes into uninvolved skin of atopic dermatitis patients. Along with the recent discovery of prevalent null mutations in the gene encoding filaggrin, a protein essential for stratum corneum formation, these data point to an innate epidermal-barrier defect in atopy.
authors.affiliation: Epithelial Genetics Group, Human Genetics Unit, Division of Pathology and Neuroscience, University of Dundee, Ninewells Hospital and Medical School, Dundee, United Kingdom. w.h.i.mclean@dundee.ac.uk
authors.forename: W H Irwin
authors.initials: WH
authors.lastname: McLean
authors.forename: Peter R
authors.initials: PR
authors.lastname: Hull
mesh_terms: D003876:Dermatitis, Atopic / Q000235:genetics / Q000378:metabolism*; D000091344:Filaggrin Proteins; D006801:Humans; D007381:Intermediate Filament Proteins / Q000235:genetics*; D009154:Mutation; D010539:Permeability; D011092:Polyethylene Glycols / Q000493:pharmacokinetics; D012867:Skin / Q000378:metabolism*
chemical_list: C000717249:FLG protein, human; D000091344:Filaggrin Proteins; D007381:Intermediate Filament Proteins; D011092:Polyethylene Glycols