title: Using enzymatic reactions to enhance the photodynamic therapy effect of porphyrin dityrosine phosphates.
abstract: This paper reports the synthesis and photodynamic therapy (PDT) effect of a porphyrin derivative containing tyrosine phosphate, which promises a new, useful approach to develop PDT agents.
authors.affiliation: Department of Chemistry, The Hong Kong University of Science & Technology, Clear Water Bay, Hong Kong, China.
authors.forename: Gaolin
authors.initials: G
authors.lastname: Liang
authors.forename: Ling
authors.initials: L
authors.lastname: Wang
authors.forename: Zhimou
authors.initials: Z
authors.lastname: Yang
authors.forename: Hokee
authors.initials: H
authors.lastname: Koon
authors.forename: Naiki
authors.initials: N
authors.lastname: Mak
authors.forename: Chi K
authors.initials: CK
authors.lastname: Chang
authors.forename: Bing
authors.initials: B
authors.lastname: Xu
mesh_terms: D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D004305:Dose-Response Relationship, Drug; D005021:Ethylamines / Q000737:chemistry; D006367:HeLa Cells; D006801:Humans; D008027:Light; D015394:Molecular Structure; D010744:Phosphoric Monoester Hydrolases / Q000737:chemistry* / Q000378:metabolism; D019000:Phosphotyrosine / Q000737:chemistry* / Q000378:metabolism; D010778:Photochemotherapy / Q000379:methods; D017319:Photosensitizing Agents / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D011166:Porphyrins / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D011524:Protoporphyrins / Q000737:chemistry; D013053:Spectrophotometry; D014230:Triazoles / Q000737:chemistry; D014508:Urea / Q000031:analogs & derivatives / Q000737:chemistry
chemical_list: D005021:Ethylamines; D017319:Photosensitizing Agents; D011166:Porphyrins; D011524:Protoporphyrins; D014230:Triazoles; D019000:Phosphotyrosine; C027070:N,N-diisopropylethylamine; D014508:Urea; D010744:Phosphoric Monoester Hydrolases; C074712:2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate