Pilomatrix carcinoma with lymph node and pulmonary metastases.
METHODS
A 72-year-old male patient developed a locally recurrent pilomatrix carcinoma (PC) of the right upper shank. Within a 2-year period he also developed bilateral pulmonary as well as inguinal, cervical and paraaortic lymph node metastases. After external-beam radiation therapy (EBRT) alone, sole interstitial high-dose-rate (HDR) brachytherapy (BRT) or postoperative EBRT with interstitial HDR-BRT boost, the patient demonstrated regressive or stable disease at the lymphatic sites. Systemic chemotherapy with intravenous paclitaxel failed to assure a substantial pulmonary response. In the course of the disease after 28 months pulmonary progression has led to continuing clinical deterioration.


CONCLUSIONS
In accordance with literature data the hitherto course of this case corroborates that radiation therapy (RT) modalities can play an important role in the treatment of PC.
Tselis
Nikolaos
N
Strahlenklinik, Klinikum Offenbach, Starkenburgring 66, 63069, Offenbach, Germany. ntselis@hotmail.com
Heyd
Reinhard
R
Vogt
Hans-Georg
HG
Zamboglou
Nikolaos
N
D000368:Aged; D001918:Brachytherapy; D003131:Combined Modality Therapy; D018450:Disease Progression; D019583:Dose Fractionation, Radiation; D005500:Follow-Up Studies; D006201:Hair Diseases / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology / Q000532:radiotherapy / Q000556:secondary*; D008197:Lymph Node Excision; D008207:Lymphatic Metastasis / Q000473:pathology / Q000532:radiotherapy*; D008279:Magnetic Resonance Imaging; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D018296:Pilomatrixoma / Q000473:pathology / Q000532:radiotherapy / Q000556:secondary* / Q000601:surgery; D011867:Radioisotope Teletherapy; D011880:Radiotherapy Planning, Computer-Assisted; D018714:Radiotherapy, Adjuvant; D019233:Retreatment; D012878:Skin Neoplasms / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D014057:Tomography, X-Ray Computed