title: [The relationship between ACE I/D polymorphism and HDL cholesterol].
abstract: OBJECTIVE
  The purpose of this study is to evaluate the association of the angiotensin converting enzyme (ACE) insertion/deletion (I/D) polymorphism with cardiovascular disease risk factors.
  
  
  METHODS
  Out of a total of 608 middle-aged adults who visited local health centers, 424 subjects (104 male, 320 female) who had not been diagnosed with hypertension, diabetes mellitus, or hyperlipidemia were included in this study. ACE genotypes were determined in all subjects by polymerase chain reaction methods.
  
  
  RESULTS
  Statistical differences in high-density lipoprotein (HDL) cholesterol levels according to ACE genotype were observed using ANOVA (p<0.05), but no differences were found in other cardiovascular risk factors. Specifically, men with the DD and DI genotypes had significantly lower HDL cholesterol levels than those with the II genotype based on the LSD multi-comparison test (p<0.05).
  
  
  CONCLUSIONS
  In men, the D-allele of the ACE I/D polymorphism was significantly associated with reduced HDL cholesterol levels. In the future, larger studies are needed to confirm this relationship between ACE I/D polymorphism and HDL cholesterol.
authors.affiliation: Department of Preventive Medicine, Medical Research Center for Cancer Molecular Therapy, College of Medicine, Dong-A University.
authors.forename: Chang Hun
authors.initials: CH
authors.lastname: You
authors.forename: Young Seoub
authors.initials: YS
authors.lastname: Hong
authors.forename: Jong Young
authors.initials: JY
authors.lastname: Kwak
authors.forename: Na Young
authors.initials: NY
authors.lastname: Kim
authors.forename: Mee Sook
authors.initials: MS
authors.lastname: Roh
authors.forename: Kap Yeol
authors.initials: KY
authors.lastname: Jung
authors.forename: Yong Hwan
authors.initials: YH
authors.lastname: Lee
authors.forename: Jung Man
authors.initials: JM
authors.lastname: Kim
authors.forename: Joon Youn
authors.initials: JY
authors.lastname: Kim
mesh_terms: D002318:Cardiovascular Diseases / Q000235:genetics / Q000503:physiopathology; D008076:Cholesterol, HDL / Q000097:blood*; D005260:Female; D015438:Health Behavior; D006801:Humans; D008297:Male; D008875:Middle Aged; D016254:Mutagenesis, Insertional; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D012307:Risk Factors; D017384:Sequence Deletion
chemical_list: D008076:Cholesterol, HDL; D007703:Peptidyl-Dipeptidase A