Synthesis, crystal structure, magnetic property and nuclease activity of a new binuclear cobalt(II) complex.
One new binuclear Co(II) complex of N,N,N',N'-tetrakis(2-benzimidazolylmethyl)-2-hydroxyl-1,3-diaminopropane (HL), [Co(2)L(mu(2)-Cl)](ClO(4))(2) x 3CH(3)CN x C(2)H(5)OC(2)H(5) (1), has been synthesized and its crystal structure and magnetic properties are shown. In 1, each Co(II) atom has a distorted trigonal bipyramidal geometry with a N(3)OCl donor set. The central two Co(II) atoms are bridged by one alkoxo-O atom and one Cl atom with the Co1-Co2 separation of 3.239 A. Susceptibility data of 1 indicate strong intramolecular antiferromagnetic coupling of the high-spin Co(II) atoms. In this paper, the interaction with calf thymus DNA was investigated by UV absorption and fluorescent spectroscopy. Results show the complex binds to ct-DNA with a intercalative mode. The interaction between complex 1 and pBR322 DNA has also been investigated by submarine gel electrophoresis, noticeably, the complex exhibits effective DNA cleavage activity in the absence of any external agents.
Tian
Jin-Lei
JL
Department of Chemistry, Nankai University, Tianjin 300071, PR China.
Feng
Li
L
Gu
Wen
W
Xu
Guang-Jun
GJ
Yan
Shi-Ping
SP
Liao
Dai-Zheng
DZ
Jiang
Zong-Hui
ZH
Cheng
Peng
P
D000818:Animals; D002417:Cattle; D003035:Cobalt / Q000737:chemistry*; D018360:Crystallography, X-Ray; D004247:DNA / Q000187:drug effects / Q000378:metabolism; D003851:Deoxyribonucleases / Q000378:metabolism; D006868:Hydrolysis; D066298:In Vitro Techniques; D008280:Magnetics; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology; D013050:Spectrometry, Fluorescence; D013053:Spectrophotometry; D013056:Spectrophotometry, Ultraviolet
D009942:Organometallic Compounds; D003035:Cobalt; D004247:DNA; D003851:Deoxyribonucleases