title: Myelodysplastic syndrome complicated with inflammatory intestinal ulcers: significance of trisomy 8.
abstract: Three cases of myelodysplastic syndrome (MDS) complicated with inflammatory intestinal ulcers all had cytogenetic abnormalities with trisomy 8. The first two patients were diagnosed with intestinal Behçets disease and were successfully treated with salazosulphapiridine, and the third patient died after leukemic transformation. We review the reported cases of MDS complicated with Behçets disease. Most of these cases are Japanese, having intestinal involvement as well as cytogenetic abnormalities with trisomy 8. We discuss the significance of trisomy 8 in intestinal involvement in MDS.
authors.affiliation: Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kawabata
authors.forename: Toshioki
authors.initials: T
authors.lastname: Sawaki
authors.forename: Takafumi
authors.initials: T
authors.lastname: Kawanami
authors.forename: Kumiko
authors.initials: K
authors.lastname: Shimoyama
authors.forename: Hiromi
authors.initials: H
authors.lastname: Karasawa
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Fukushima
authors.forename: Yasufumi
authors.initials: Y
authors.lastname: Masaki
authors.forename: Noriyoshi
authors.initials: N
authors.lastname: Ogawa
authors.forename: Yuko
authors.initials: Y
authors.lastname: Hirose
authors.forename: Kazuaki
authors.initials: K
authors.lastname: Ozaki
authors.forename: Koshi
authors.initials: K
authors.lastname: Shimanaka
authors.forename: Shujiro
authors.initials: S
authors.lastname: Takase
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ueno
authors.forename: Hisanori
authors.initials: H
authors.lastname: Umehara
mesh_terms: D000368:Aged; D001528:Behcet Syndrome / Q000150:complications; D001853:Bone Marrow / Q000473:pathology; D002898:Chromosomes, Human, Pair 8; D005260:Female; D006801:Humans; D007249:Inflammation / Q000150:complications*; D007410:Intestinal Diseases / Q000150:complications*; D008297:Male; D009190:Myelodysplastic Syndromes / Q000150:complications* / Q000235:genetics* / Q000473:pathology; D014314:Trisomy; D014456:Ulcer / Q000150:complications*