title: Scavenging effect and antispasmodic activity of the essential oil of Cyclotrichium niveum.
abstract: The radical scavenging and the spasmolitic activity of Cyclotrichium niveum essential oil were evaluated in vitro. It showed an IC(50) of 1750 microg/ml on DPPH method and dose dependently (0.1, 0.5 and 1 mg/ml) inhibits the contraction induced by carbachol on rabbit bladder from 15 to 100%. Moreover, it was able to inhibit the rat ileum muscle by 30 to 100%.
authors.affiliation: Department of Chemistry, Faculty of Science and Literature, Cumhuriyet University, 58140 Turkey. scetinus@cumhuriyet.edu.tr
authors.forename: Senay Akkuş
authors.initials: SA
authors.lastname: Cetinus
authors.forename: Ismihan
authors.initials: I
authors.lastname: Göze
authors.forename: Bülent
authors.initials: B
authors.lastname: Saraç
authors.forename: Nilüfer
authors.initials: N
authors.lastname: Vural
mesh_terms: D000818:Animals; D001713:Biphenyl Compounds; D002217:Carbachol; D004305:Dose-Response Relationship, Drug; D005260:Female; D016166:Free Radical Scavengers / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D010276:Parasympatholytics / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D008517:Phytotherapy; D010851:Picrates / Q000737:chemistry; D035261:Plant Components, Aerial; D010938:Plant Oils / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D010946:Plants, Medicinal; D011817:Rabbits; D051381:Rats; D017208:Rats, Wistar; D001743:Urinary Bladder / Q000187:drug effects
chemical_list: D001713:Biphenyl Compounds; D016166:Free Radical Scavengers; D010276:Parasympatholytics; D010851:Picrates; D010938:Plant Oils; D002217:Carbachol; C004931:1,1-diphenyl-2-picrylhydrazyl