title: HLA-G, -E and -F: allelism, function and evolution.
abstract: The major histocompatibility complex class I genes comprise a bunch of classical genes (A, B, C), non-classical genes (E, F and G), pseudogenes and truncated genes. MHC-E, -F and -G are now considered immune "tolerization" molecules, which not only interact with NK cells but with T lymphocyte subsets and other cells and have a role in fetus acceptation. A strong positive directional selection is acting for maintaining the observed low polymorphism on E, F and G loci in human and apes. Invariance must be important for this non-classical class I proteins function.
authors.affiliation: Department of Immunology, Universidad Complutense, The Madrid Regional Blood Center, Madrid, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Moscoso
authors.forename: J I
authors.initials: JI
authors.lastname: Serrano-Vela
authors.forename: R
authors.initials: R
authors.lastname: Pacheco
authors.forename: A
authors.initials: A
authors.lastname: Arnaiz-Villena
mesh_terms: D000483:Alleles; D000818:Animals; D001483:Base Sequence; D017931:DNA Primers / Q000235:genetics; D019143:Evolution, Molecular; D005260:Female; D005333:Fetus / Q000276:immunology; D014644:Genetic Variation; D006680:HLA Antigens / Q000737:chemistry / Q000235:genetics* / Q000276:immunology*; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I / Q000737:chemistry / Q000235:genetics* / Q000276:immunology*; D006801:Humans; D007108:Immune Tolerance; D008958:Models, Molecular; D011247:Pregnancy; D011323:Primates / Q000235:genetics / Q000276:immunology; D000097625:HLA-E Antigens
chemical_list: D017931:DNA Primers; D006680:HLA Antigens; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I; D000097625:HLA-E Antigens; C062341:HLA-F antigens