title: Effects of different stages of endometriosis on the outcome of in vitro fertilization.
abstract: OBJECTIVE
  This study was undertaken to evaluate the effects of different stages of endometriosis on the outcome of treatment in an in vitro fertilization (IVF) program.
  
  
  METHODS
  This was a retrospective, matched case-control study in an academic tertiary referral centre. The study group consisted of 87 women with laparoscopically diagnosed endometriosis, and the control group consisted of 87 age-matched women undergoing IVF for different reasons. The primary outcomes were duration of stimulation, total gonadotropin dose requirement, peak serum estradiol level, total number of oocytes retrieved, fertilization rate, embryo quality, implantation rate, and clinical pregnancy rate. The effect of obliteration of the cul-de-sac by endometriosis was also evaluated.
  
  
  RESULTS
  Women with endometriosis required significantly higher gonadotropin doses than women in the control group (P < 0.01). The fertilization rate was significantly lower for women with endometriosis (P < 0.05), although there was no difference in embryo quality or in the number of embryos transferred. In patients with an obliterated cul-de-sac, fewer oocytes were retrieved than in patients in the control group (P < 0.01).
  
  
  CONCLUSIONS
  The presence of endometriosis, including stages III and IV, does not affect IVF outcome. However, women with endometriosis require more gonadotropin stimulation than those with no endometriosis. Women with an obliterated cul-de-sac have fewer oocytes retrieved than women without obliteration.
authors.affiliation: Department of Obstetrics and Gynecology, McGill University, Montreal QC.
authors.forename: Raedah
authors.initials: R
authors.lastname: Al-Fadhli
authors.affiliation: Department of Obstetrics and Gynecology, McGill University, Montreal QC.
authors.forename: Simon M
authors.initials: SM
authors.lastname: Kelly
authors.affiliation: Department of Obstetrics and Gynecology, McGill University, Montreal QC.
authors.forename: Togas
authors.initials: T
authors.lastname: Tulandi
authors.affiliation: Department of Obstetrics and Gynecology, McGill University, Montreal QC.
authors.forename: Seang
authors.initials: S
authors.lastname: Lin Tan
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D010064:Embryo Implantation / Q000502:physiology*; D004624:Embryo Transfer; D004715:Endometriosis / Q000150:complications*; D005260:Female; D005307:Fertilization in Vitro; D005640:Follicle Stimulating Hormone / Q000494:pharmacology*; D006801:Humans; D009865:Oocytes / Q000502:physiology; D017063:Outcome Assessment, Health Care; D011247:Pregnancy; D018873:Pregnancy Rate; D012189:Retrospective Studies
chemical_list: D005640:Follicle Stimulating Hormone