title: Comparative study of pathological changes in the mouse viscera in infection caused by two orthopoxviruses.
abstract: The mechanisms of infection development in intraperitoneal inoculation of mice by ectromelia virus strain K-1 and cowpox strain EP-2 were studied. Ultrastructural parameters of virus assembly and maturation are described. Differences in the types of cells replicating the viruses and in the type of visceral injuries were detected. The studies showed a local type of strain EP-2 cowpox infection and dissemination of ectromelia strain K-1.
authors.affiliation: Vector State Research Center of Virology and Biotechnology, Novosibirsk.
authors.forename: I V
authors.initials: IV
authors.lastname: Vinogradov
authors.forename: G V
authors.initials: GV
authors.lastname: Kochneva
authors.forename: E M
authors.initials: EM
authors.lastname: Malkova
authors.forename: S N
authors.initials: SN
authors.lastname: Shchelkunov
authors.forename: E I
authors.initials: EI
authors.lastname: Ryabchikova
mesh_terms: D000818:Animals; D017209:Apoptosis; D015608:Cowpox virus / Q000378:metabolism; D003593:Cytoplasm / Q000378:metabolism; D005347:Fibroblasts / Q000648:ultrastructure; D008214:Lymphocytes / Q000473:pathology / Q000648:ultrastructure; D008264:Macrophages / Q000821:virology; D008297:Male; D051379:Mice; D018155:Orthopoxvirus / Q000378:metabolism*; D010537:Peritoneum / Q000648:ultrastructure; D011213:Poxviridae Infections / Q000821:virology; D013154:Spleen / Q000648:ultrastructure; D014781:Viscera / Q000473:pathology* / Q000821:virology*