Streptococcus pneumoniae pilus subunits protect mice against lethal challenge.
Streptococcus pneumoniae is a major public health threat worldwide. The recent discovery that this pathogen possesses pili led us to investigate their protective abilities in a mouse model of intraperitoneal infection. Both active and passive immunization with recombinant pilus subunits afforded protection against lethal challenge with the S. pneumoniae serotype 4 strain TIGR4.
Gianfaldoni
Claudia
C
Novartis Vaccines and Diagnostics s.r.l., Research Center, Via Fiorentina 1, I-53100 Siena, Italy.
Censini
Stefano
S
Hilleringmann
Markus
M
Moschioni
Monica
M
Facciotti
Claudia
C
Pansegrau
Werner
W
Masignani
Vega
V
Covacci
Antonello
A
Rappuoli
Rino
R
Barocchi
Michèle Anne
MA
Ruggiero
Paolo
P
D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood; D000942:Antigens, Bacterial / Q000008:administration & dosage / Q000276:immunology*; D016470:Bacteremia; D004195:Disease Models, Animal; D005260:Female; D010861:Fimbriae, Bacterial / Q000276:immunology*; D007116:Immunization, Passive; D051379:Mice; D008807:Mice, Inbred BALB C; D011008:Pneumococcal Infections / Q000517:prevention & control*; D022242:Pneumococcal Vaccines / Q000276:immunology*; D013296:Streptococcus pneumoniae / Q000276:immunology*; D016019:Survival Analysis; D014611:Vaccination; D022223:Vaccines, Subunit / Q000276:immunology; D014614:Vaccines, Synthetic / Q000276:immunology
D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D022242:Pneumococcal Vaccines; D022223:Vaccines, Subunit; D014614:Vaccines, Synthetic