title: Asperpyrone D and other metabolites of the plant-associated fungal strain Aspergillus tubingensis.
abstract: Bioactivity-guided fractionation of a cytotoxic extract of Aspergillus tubingensis, a fungal strain occurring in the rhizosphere of the Sonoran desert plant, Fallugia paradoxa, afforded a dimeric naphtho-gamma-pyrone asperpyrone D, nine known naphtho-gamma-pyrones, funalenone, and the cytotoxic cyclic penta-peptide, malformin A1.
authors.affiliation: Southwest Center for Natural Products Research and Commercialization, Office of Arid Lands Studies, College of Agriculture and Life Sciences, The University of Arizona, 250 East Valencia Road, Tucson, AZ 85706-6800, USA.
authors.forename: Jixun
authors.initials: J
authors.lastname: Zhan
authors.forename: G M Kamal B
authors.initials: GM
authors.lastname: Gunaherath
authors.forename: E M Kithsiri
authors.initials: EM
authors.lastname: Wijeratne
authors.forename: A A Leslie
authors.initials: AA
authors.lastname: Gunatilaka
mesh_terms: D001230:Aspergillus / Q000378:metabolism*; D045744:Cell Line, Tumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D009281:Naphthalenes / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism*; D010944:Plants / Q000382:microbiology*; D011753:Pyrones / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism*; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D009281:Naphthalenes; D011753:Pyrones; C518859:asperpyrone D