Flipping off the riboswitch: RNA structures that control gene expression.
Riboswitches are metabolite-sensing RNA structures that have been discovered in regulatory regions of messenger RNA (mRNA). They have the remarkable ability to shut off the transcription or translation of their own mRNAs in response to binding a specific metabolite. In other words, riboswitches regulate their own genes using RNA instead of protein. Three new crystal structures reveal how S-adenosylmethionine and thiamine pyrophosphate riboswitches accomplish this task.
Sashital
Dipali G
DG
Department of Biochemistry, University of Wisconsin-Madison, 433 Babcock Drive, Madison, Wisconsin 53706, USA.
Butcher
Samuel E
SE
D000818:Animals; D052157:Aptamers, Nucleotide / Q000737:chemistry*; D005786:Gene Expression Regulation / Q000235:genetics*; D006801:Humans; D012313:RNA / Q000737:chemistry* / Q000502:physiology; D012436:S-Adenosylmethionine / Q000737:chemistry* / Q000235:genetics / Q000502:physiology; D013835:Thiamine Pyrophosphate / Q000737:chemistry* / Q000235:genetics / Q000502:physiology*
D052157:Aptamers, Nucleotide; D012313:RNA; D012436:S-Adenosylmethionine; D013835:Thiamine Pyrophosphate