title: Toll-like receptor-2-mediated C-C chemokine receptor 3 and eotaxin-driven eosinophil influx induced by Mycobacterium bovis BCG pleurisy.
abstract: An acute and persistent eosinophil infiltration is observed during Mycobacterium bovis BCG pleural infection in mice. Eosinophil accumulation, lipid body formation, and eotaxin production were significantly reduced in BCG-infected Toll-like receptor-2 (TLR2)-deficient mice compared to wild-type mice. Neutralization of eotaxin or CCR3 drastically inhibited BCG-induced eosinophil accumulation and lipid body formation, indicating that BCG-induced eosinophil recruitment and activation is largely dependent of TLR2-mediated eotaxin generation.
authors.affiliation: Laboratório de Imunofarmacologia, Departamento de Fisiologia e Farmacodinâmica, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Av. Brasil 4365, Manguinhos, Rio de Janeiro 21045-900, Brazil.
authors.forename: Heloisa
authors.initials: H
authors.lastname: D'Avila
authors.forename: Patrícia E
authors.initials: PE
authors.lastname: Almeida
authors.forename: Natália R
authors.initials: NR
authors.lastname: Roque
authors.forename: Hugo C
authors.initials: HC
authors.lastname: Castro-Faria-Neto
authors.forename: Patrícia T
authors.initials: PT
authors.lastname: Bozza
mesh_terms: D000818:Animals; D054413:Chemokine CCL11; D019742:Chemokines, CC / Q000502:physiology*; D002631:Chemotactic Factors, Eosinophil / Q000502:physiology*; D002634:Chemotaxis, Leukocyte / Q000276:immunology*; D004804:Eosinophils / Q000166:cytology / Q000276:immunology* / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D009163:Mycobacterium bovis / Q000276:immunology*; D054397:Receptors, CCR3; D019707:Receptors, Chemokine / Q000502:physiology*; D051195:Toll-Like Receptor 2 / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D014396:Tuberculosis, Pleural / Q000276:immunology* / Q000378:metabolism / Q000662:veterinary
chemical_list: C515457:Ccl11 protein, mouse; C515351:Ccr3 protein, mouse; D054413:Chemokine CCL11; D019742:Chemokines, CC; D002631:Chemotactic Factors, Eosinophil; D054397:Receptors, CCR3; D019707:Receptors, Chemokine; C493486:Tlr2 protein, mouse; D051195:Toll-Like Receptor 2