Myoelectric activity and motility of the Roux limb after cut or uncut Roux-en-Y gastrojejunostomy.
OBJECTIVE
To explore the mechanisms of uncut Roux-en-Y gastrojejunostomy, which is used to decrease the occurrence of Roux stasis syndrome.


METHODS
The changes of myoelectric activity, mechanic motility and interstitial cells of Cajal (ICC) of the Roux limb after cut or uncut Roux-en-Y gastrojejunostomy were observed.


RESULTS
When compared with the cut group, the amplitude (1.15 +/- 0.15 mV vs 0.48 +/- 0.06 mV, P < 0.05) and frequency (14.4 +/- 1.9 cpm vs 9.5 +/- 1.1 cpm, P < 0.01) of slow waves and the incidence (98.2% +/- 10.4% vs 56.6% +/- 6.4%, P < 0.05) and amplitude (0.58 +/- 0.08 mV vs 0.23 +/- 0.06 mV, P < 0.01) of spike potential of the Roux limb in the uncut group were significantly higher. The migrating myoelectric complexes (MMC) phase III duration in the uncut group was significantly prolonged (6.5 +/- 1.1 min vs 4.4 +/- 0.8 min, P < 0.05), while the MMC cycle obviously shortened (42.5 +/- 6.8 vs 55.3 +/- 8.2 min, P < 0.05). Both gastric emptying rate (65.5% +/- 7.9% vs 49.3% +/- 6.8%, P < 0.01) and intestinal impelling ratio (53.4% +/- 7.4% vs 32.2% +/- 5.4%, P < 0.01) in the uncut group were significantly increased. The contractile force index of the isolated jejunal segment in the uncut group was significantly higher (36.8 +/- 5.1 vs 15.3 +/- 2.2, P < 0.01), and the expression of c-kit mRNA was significantly increased in the uncut group (0.82 +/- 0.11 vs 0.35 +/- 0.06, P < 0.01).


CONCLUSIONS
Uncut Roux-en-Y gastrojejunostomy may lessen the effects of operation on myoelectric activity such as slow waves, spike potential, and MMC, decrease the impairment of gastrointestinal motility, and remarkably increase the expression of c-kit mRNA.
Zhang
Ying-Mei
YM
Central Laboratory, First Clinical College of Harbin Medical University, Harbin 150001, Heilongjiang Province, China.
Liu
Xiu-Li
XL
Xue
Dong-Bo
DB
Wei
Yun-Wei
YW
Yun
Xiao-Guang
XG
D000713:Anastomosis, Roux-en-Y / Q000379:methods*; D000818:Animals; D015390:Gastric Bypass / Q000379:methods*; D005769:Gastrointestinal Motility / Q000502:physiology*; D008297:Male; D016065:Myoelectric Complex, Migrating / Q000502:physiology*; D011183:Postoperative Complications / Q000503:physiopathology* / Q000517:prevention & control; D051381:Rats; D017208:Rats, Wistar