title: Genetic influences on variation in female orgasmic function: a twin study.
abstract: Orgasmic dysfunction in females is commonly reported in the general population with little consensus on its aetiology. We performed a classical twin study to explore whether there were observable genetic influences on female orgasmic dysfunction. Adult females from the TwinsUK register were sent a confidential survey including questions on sexual problems. Complete responses to the questions on orgasmic dysfunction were obtained from 4037 women consisting of 683 monozygotic and 714 dizygotic pairs of female twins aged between 19 and 83 years. One in three women (32%) reported never or infrequently achieving orgasm during intercourse, with a corresponding figure of 21% during masturbation. A significant genetic influence was seen with an estimated heritability for difficulty reaching orgasm during intercourse of 34% (95% confidence interval 27-40%) and 45% (95% confidence interval 38-52%) for orgasm during masturbation. These results show that the wide variation in orgasmic dysfunction in females has a genetic basis and cannot be attributed solely to cultural influences. These results should stimulate further research into the biological and perhaps evolutionary processes governing female sexual function.
authors.affiliation: Primary Care Sciences Research Centre, Keele University, Staffordshire ST5 5BG, UK.
authors.forename: Kate M
authors.initials: KM
authors.lastname: Dunn
authors.forename: Lynn F
authors.initials: LF
authors.lastname: Cherkas
authors.forename: Tim D
authors.initials: TD
authors.lastname: Spector
mesh_terms: D000328:Adult; D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D014644:Genetic Variation / Q000502:physiology*; D006801:Humans; D008297:Male; D008418:Masturbation / Q000453:epidemiology / Q000473:pathology / Q000523:psychology; D008875:Middle Aged; D009948:Orgasm / Q000502:physiology*; D012725:Sexual Behavior / Q000502:physiology / Q000523:psychology; D020018:Sexual Dysfunctions, Psychological / Q000453:epidemiology / Q000503:physiopathology; D018433:Twin Studies as Topic; D014429:Twins, Dizygotic / Q000235:genetics; D014430:Twins, Monozygotic / Q000235:genetics; D016387:Women's Health