Identification of a Smad phosphatase.
Activation of Smad signaling pathways downstream of TGF-beta superfamily ligands via receptor-mediated Smad phosphorylation is well understood, but little is known about the phosphatases that turn off Smad activity. Now in Cell, Feng and colleagues (Lin, X., et al. (2006) Cell 125 , 915-928) report their discovery that PPM1A acts as a Smad phosphatase to terminate TGF-beta signaling.
Hill
Caroline S
CS
Cancer Research UK London Research Institute, 44 Lincoln's Inn Fields, London, WC2A 3PX, United Kingdom. caroline.hill@cancer.org.uk
D000818:Animals; D006801:Humans; D010749:Phosphoprotein Phosphatases / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D010744:Phosphoric Monoester Hydrolases / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D051896:Smad Proteins, Receptor-Regulated / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D016212:Transforming Growth Factor beta / Q000037:antagonists & inhibitors / Q000502:physiology
D051896:Smad Proteins, Receptor-Regulated; D016212:Transforming Growth Factor beta; D010749:Phosphoprotein Phosphatases; D010744:Phosphoric Monoester Hydrolases