Alternative splicing of human and mouse NPFF2 receptor genes: Implications to receptor expression.
Alternative splicing has an important role in the tissue-specific regulation of gene expression. Here we report that similar to the human NPFF2 receptor, the mouse NPFF2 receptor is alternatively spliced. In human the presence of three alternatively spliced receptor variants were verified, whereas two NPFF2 receptor variants were identified in mouse. The alternative splicing affected the 5' untranslated region of the mouse receptor and the variants in mouse were differently distributed. The mouse NPFF system may also have species-specific features since the NPFF2 receptor mRNA expression differs from that reported for rat.
Ankö
Minna-Liisa
ML
Department of Biology, Abo Akademi University, Tykistökatu 6A, 2nd floor, FI-20520 Turku, Finland.
Ostergård
Maria
M
Lintunen
Minnamaija
M
Panula
Pertti
P
D017398:Alternative Splicing / Q000235:genetics*; D000818:Animals; D001483:Base Sequence; D002490:Central Nervous System / Q000378:metabolism; D006801:Humans; D017403:In Situ Hybridization; D051379:Mice; D008969:Molecular Sequence Data; D020033:Protein Isoforms / Q000235:genetics; D012333:RNA, Messenger / Q000235:genetics; D018013:Receptors, Neuropeptide / Q000235:genetics* / Q000378:metabolism*
D020033:Protein Isoforms; D012333:RNA, Messenger; D018013:Receptors, Neuropeptide; C083929:neuropeptide FF receptor