Novel aspects of prions, their receptor molecules, and innovative approaches for TSE therapy.
1. Prion diseases are a group of rare, fatal neurodegenerative diseases, also known as transmissible spongiform encephalopathies (TSEs), that affect both animals and humans and include bovine spongiform encephalopathy (BSE) in cattle, scrapie in sheep, chronic wasting disease (CWD) in deer and elk, and Creutzfeldt-Jakob disease (CJD) in humans. TSEs are usually rapidly progressive and clinical symptoms comprise dementia and loss of movement coordination due to the accumulation of an abnormal isoform (PrP(Sc)) of the host-encoded prion protein (PrP(c)). 2. This article reviews the current knowledge on PrP(c) and PrP(Sc), prion replication mechanisms, interaction partners of prions, and their cell surface receptors. Several strategies, summarized in this article, have been investigated for an effective antiprion treatment including development of a vaccination therapy and screening for potent chemical compounds. Currently, no effective treatment for prion diseases is available. 3. The identification of the 37 kDa/67 kDa laminin receptor (LRP/LR) and heparan sulfate as cell surface receptors for prions, however, opens new avenues for the development of alternative TSE therapies.
Vana
Karen
K
Laboratorium für Molekulare Biologie, Genzentrum, Institut für Biochemie der Ludwig-Maximilians-Universität München, Feodor-Lynen-Str. 25, 81377, München, Germany.
Zuber
Chantal
C
Nikles
Daphne
D
Weiss
Stefan
S
D000818:Animals; D004261:DNA Replication; D006497:Heparan Sulfate / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D017096:Prion Diseases / Q000628:therapy*; D011328:Prions / Q000378:metabolism / Q000502:physiology*; D017474:Receptors, Laminin / Q000378:metabolism / Q000502:physiology*
D006497:Heparan Sulfate; D011328:Prions; D017474:Receptors, Laminin