Sugihiratake mushroom (angel's wing mushroom)-induced cryptogenic encephalopathy may involve vitamin D analogues.
In autumn 2004, many Japanese patients with renal failure developed cryptogenic encephalopathy by consuming sugihiratake mushroom, a Japanese delicacy. To elucidate the relationship between the cryptogenic cases and this mushroom, we conducted a multivariate analysis of metabolites in 'Probably Toxic' sugihiratake collected from the area of encephalopathy outbreaks, and 'Probably Safe' sugihiratake collected from unaffected areas using UPLC/ToF MS. The results indicate that the presence of milligram quantities of vitamin D-like compounds per 10 g of dried sugihiratake from the areas of encephalopathy outbreaks. Two hypotheses to induce the encephalopathy are proposed: the found metabolites are (1) vitamin D agonists, which induce acute and severe hypercalcemia and/or hyperammonemia and/or vitamin D toxicity, or (2) vitamin D antagonists, which induce acute and severe hypocalcemia.
Sasaki
Hideki
H
Nihon Waters K.K., Tokyo, Japan. hideki_sasaki@waters.com
Akiyama
Hiroshi
H
Yoshida
Yoshifumi
Y
Kondo
Kazunari
K
Amakura
Yoshiaki
Y
Kasahara
Yoshimasa
Y
Maitani
Tamio
T
D000363:Agaricales; D001927:Brain Diseases / Q000209:etiology*; D005517:Foodborne Diseases; D006801:Humans; D013058:Mass Spectrometry; D014807:Vitamin D / Q000031:analogs & derivatives*
D014807:Vitamin D