[Effect of vilon on neuroendocrine status and sexual function of old male rats].
The hypogonadal status of hemigonadectomised male rats has been choseh as a model of age-related sexual function decline in animals. The effect of dipeptide Vilon on parameters of sexual function and neuroendocrine status was studied. The results showed that regular introduction of Vilon in a dose of 50 microg per rat activates sexual function in old male rats. The obtained data confirm that Vilon significantly affects neuroendocrine status of animals, as well as the level of LH, prolactin and ACTH and changes the content of neurotransmitters in hypothalamus. We consider the changes in sexual function caused by Vilon not relate to change in one parameter only, but are mediated by a set of neuroendocrine and neuromediatorial factors. Significant decrease in prolactin content in blood is worthy of notice, as age-related hypersecretion of this hormone is one of the main factors leading to age-related sexual function decline.
Kudriavtseva
T A
TA
Zaĭchenko
I N
IN
Efremov
O M
OM
Baĭramov
A A
AA
Grigor'ev
E I
EI
Ryzhak
G A
GA
D000324:Adrenocorticotropic Hormone / Q000097:blood; D000375:Aging / Q000097:blood / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D004151:Dipeptides / Q000494:pharmacology*; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D009490:Neurosecretory Systems / Q000187:drug effects* / Q000378:metabolism; D009919:Orchiectomy; D011388:Prolactin / Q000097:blood; D051381:Rats; D012726:Sexual Behavior, Animal / Q000187:drug effects*; D013739:Testosterone / Q000097:blood
D004151:Dipeptides; D013739:Testosterone; D000324:Adrenocorticotropic Hormone; D011388:Prolactin; D007986:Luteinizing Hormone; C415909:lysylglutamic acid