title: [Clinical application of collagen].
abstract: OBJECTIVE
  To review and evaluate the extensive and further research and the application of the collagen-based biomaterials in the field of clinical medicine.
  
  
  METHODS
  The clinical research and application of collagen-based biomaterials were comprehensively reviewed and evaluated on the basis of the up-to-date publications and our practical experiences in their studies and manufacturing.
  
  
  RESULTS
  The following five aspects concerned with the collagen-based biomaterials were evaluated: biological property, quality control, formulation of substrate and clinical application, immunogenicity and clinical side effect, and potential of the market development.
  
  
  CONCLUSIONS
  Collagen-based biomaterials have a great potential and market space in their clinical application.
authors.affiliation: Shanghai Qisheng Institute of Biomaterial & Technology, PR China. qish@shqisheng.com
authors.forename: Qisheng
authors.initials: Q
authors.lastname: Gu
mesh_terms: D001672:Biocompatible Materials; D003094:Collagen; D006801:Humans
chemical_list: D001672:Biocompatible Materials; D003094:Collagen