title: Development of a tissue-engineered bypass graft seeded with stem cells.
abstract: The gold standard conduit for bypass of diseased small-diameter arteries remains autologous vascular tissue. In the absence of such tissue, patients are offered bypass with prosthetic material, with far less durable results. Vascular tissue engineering, the creation of a vascular conduit by seeding a tubular scaffold with various cells, may offer an alternative approach to this difficult situation. Herein we review some of the significant challenges that remain in designing an ideal vascular conduit and outline potential solutions offered by a graft created by seeding natural vascular tissue (decellularized vein allograft) with readily available autologous cells (adipose-derived stem cells).
authors.affiliation: Department of Surgery, Thomas Jefferson University, Philadelphia, PA, USA.
authors.forename: Paul
authors.initials: P
authors.lastname: DiMuzio
authors.forename: Lauren
authors.initials: L
authors.lastname: Fischer
authors.forename: Stephen
authors.initials: S
authors.lastname: McIlhenny
authors.forename: Christopher
authors.initials: C
authors.lastname: DiMatteo
authors.forename: Negar
authors.initials: N
authors.lastname: Golesorhki
authors.forename: Daniel
authors.initials: D
authors.lastname: Grabo
authors.forename: Nicholas
authors.initials: N
authors.lastname: Tarola
authors.forename: Alexander
authors.initials: A
authors.lastname: Mericli
authors.forename: Irving
authors.initials: I
authors.lastname: Shapiro
authors.forename: Thomas
authors.initials: T
authors.lastname: Tulenko
mesh_terms: D017667:Adipocytes / Q000502:physiology*; D000818:Animals; D001672:Biocompatible Materials; D001705:Bioprosthesis; D001807:Blood Vessel Prosthesis; D019917:Blood Vessel Prosthesis Implantation / Q000295:instrumentation*; D018929:Cell Culture Techniques; D002454:Cell Differentiation; D019070:Cell Lineage; D049109:Cell Proliferation; D002478:Cells, Cultured; D042783:Endothelial Cells / Q000502:physiology*; D006801:Humans; D011474:Prosthesis Design; D033581:Stem Cell Transplantation; D013234:Stem Cells / Q000502:physiology*; D023822:Tissue Engineering / Q000379:methods
chemical_list: D001672:Biocompatible Materials