[Structure peculiarities of muscle regenerates and state of thymus under He-Ne laser therapy in different periods after muscle trauma].
We studied the gastrocnemius muscle regeneration and the reactive changes in thymus of rats under different regimens of He-Ne laser therapy of both operated legs (632.8 nm; 2.5-3.0 mW/cm(2) ). Laser radiation (10 exposures by 3 min within 1-15 days after muscle trauma, 4.5-5.4 J/cm(2) total dose per each leg) stimulated inflammatory reaction, muscle healing and favored preservation of muscle tissue in regenerates. The changes in thymus mass, its histological structure, size of cortex and thymocite mitotic index pointed to the increase of the functional load on thymus and delay of its recovery. The same dose of laser therapy of muscles within 16-30 days after trauma led to the increase of muscle tissue sclerotization in regenerates. The reactive changes in thymus were less pronounced. Threefold decrease of laser dose (10 exposures by 1 min for 1-15 days, 1.5-1.8 J/cm(2)) suppressed inflammatory reaction, impaired the muscle regeneration. The increase of functional activity in thymus was not observed.
Buliakova
N V
NV
Azarova
V S
VS
D000818:Animals; D004307:Dose-Response Relationship, Radiation; D005260:Female; D028022:Low-Level Light Therapy; D008938:Mitosis / Q000528:radiation effects*; D018482:Muscle, Skeletal / Q000293:injuries* / Q000378:metabolism / Q000473:pathology; D009929:Organ Size / Q000528:radiation effects; D051381:Rats; D013950:Thymus Gland / Q000378:metabolism / Q000473:pathology / Q000528:radiation effects*; D013997:Time Factors; D014945:Wound Healing / Q000528:radiation effects*; D014947:Wounds and Injuries / Q000378:metabolism / Q000473:pathology / Q000532:radiotherapy*