title: Oxidative stress and protein oxidation in pseudoexfoliation syndrome.
abstract: OBJECTIVE
  To investigate the oxidant/antioxidant status and protein oxidation in pseudoexfoliation syndrome.
  
  
  METHODS
  The activity of serum superoxide dismutase (SOD) and the levels of serum malondialdehyde (MDA) and protein carbonyl (PC) were measured in 50 patients with pseudoexfoliation (PEX) and in 55 healthy controls.
  
  
  RESULTS
  There was significant difference in the SOD activity in PEX group compared with the control group (p < 0.001). In addition, MDA and PC levels were significantly higher in patients than in the controls (p < 0.001).
  
  
  CONCLUSIONS
  Decrease in SOD activity and the higher levels of MDA and PC indicate increased oxidative stress. Our results suggest a possible role of oxidative stress in pathology of PEX syndrome.
authors.affiliation: Department of Ophthalmology, Fatih University, Medical School, Ankara, Turkey. ramazanyagci@yahoo.com
authors.forename: Ramazan
authors.initials: R
authors.lastname: Yağci
authors.forename: Ahmet
authors.initials: A
authors.lastname: Gürel
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Ersöz
authors.forename: Uğgur C
authors.initials: UC
authors.lastname: Keskin
authors.forename: Ibrahim F
authors.initials: IF
authors.lastname: Hepşen
authors.forename: Sunay
authors.initials: S
authors.lastname: Duman
authors.forename: Ramazan
authors.initials: R
authors.lastname: Yiğitoğlu
mesh_terms: D000368:Aged; D017889:Exfoliation Syndrome / Q000097:blood*; D006801:Humans; D008315:Malondialdehyde / Q000097:blood*; D008875:Middle Aged; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D050050:Protein Carbonylation; D013482:Superoxide Dismutase / Q000097:blood*
chemical_list: D008315:Malondialdehyde; D013482:Superoxide Dismutase