Pin1 flips Alzheimer's switch.
The biochemical processes leading to Alzheimer's disease are just now being elucidated. A recent study shows that a peptidyl-prolyl isomerase, Pin1, specifically regulates the degradation of amyloid precursor protein (APP). An alternative model for Pin1 regulation of APP processing is also proposed.
Etzkorn
Felicia A
FA
Department of Chemistry, Virginia Tech, Blacksburg, Virgina 24061, USA. fetzkorn@vt.edu
D000544:Alzheimer Disease / Q000378:metabolism* / Q000517:prevention & control; D016564:Amyloid beta-Protein Precursor / Q000737:chemistry / Q000378:metabolism*; D000818:Animals; D006801:Humans; D008954:Models, Biological; D000072340:NIMA-Interacting Peptidylprolyl Isomerase; D019696:Peptidylprolyl Isomerase / Q000737:chemistry* / Q000378:metabolism / Q000502:physiology*
D016564:Amyloid beta-Protein Precursor; D000072340:NIMA-Interacting Peptidylprolyl Isomerase; C000606846:PIN1 protein, human; D019696:Peptidylprolyl Isomerase