title: Sequential one-pot bimetallic Ir(III)/Pd(0) catalysed mono-/bis-alkylation and spirocyclisation processes of 1,3-dimethylbarbituric acid and allenes.
abstract: Microwave assisted indirect functionalization of alcohols with 1,3-dimethylbarbituric acid followed by spirocyclisation employing a sequential one-pot Ir(III)/Pd(0) catalysed process, involving the formation of three new C-C bonds, one spirocyclic ring and one di- or tri-substituted exocyclic alkene, is described.
authors.affiliation: Molecular Innovation, Diversity and Automated Synthesis Centre, School of Chemistry, University of Leeds, Leeds, UK.
authors.forename: Christian
authors.initials: C
authors.lastname: Löfberg
authors.forename: Ronald
authors.initials: R
authors.lastname: Grigg
authors.forename: Ann
authors.initials: A
authors.lastname: Keep
authors.forename: Andrew
authors.initials: A
authors.lastname: Derrick
authors.forename: Visuvanathar
authors.initials: V
authors.lastname: Sridharan
authors.forename: Colin
authors.initials: C
authors.lastname: Kilner
mesh_terms: D000466:Alkadienes / Q000737:chemistry*; D000478:Alkylation; D001463:Barbiturates / Q000138:chemical synthesis* / Q000737:chemistry; D001592:Benzyl Alcohols / Q000737:chemistry; D002384:Catalysis; D018360:Crystallography, X-Ray; D003500:Cyclization; D006571:Heterocyclic Compounds / Q000138:chemical synthesis / Q000737:chemistry; D007495:Iridium / Q000737:chemistry*; D008872:Microwaves; D008958:Models, Molecular; D008968:Molecular Conformation; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D013141:Spiro Compounds / Q000138:chemical synthesis / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000466:Alkadienes; D001463:Barbiturates; D001592:Benzyl Alcohols; D006571:Heterocyclic Compounds; D013141:Spiro Compounds; D007495:Iridium; C025947:propadiene; D010165:Palladium; C018924:1,3-dimethylbarbituric acid