Development of a tissue-engineered bypass graft seeded with stem cells.
The gold standard conduit for bypass of diseased small-diameter arteries remains autologous vascular tissue. In the absence of such tissue, patients are offered bypass with prosthetic material, with far less durable results. Vascular tissue engineering, the creation of a vascular conduit by seeding a tubular scaffold with various cells, may offer an alternative approach to this difficult situation. Herein we review some of the significant challenges that remain in designing an ideal vascular conduit and outline potential solutions offered by a graft created by seeding natural vascular tissue (decellularized vein allograft) with readily available autologous cells (adipose-derived stem cells).
DiMuzio
Paul
P
Department of Surgery, Thomas Jefferson University, Philadelphia, PA, USA.
Fischer
Lauren
L
McIlhenny
Stephen
S
DiMatteo
Christopher
C
Golesorhki
Negar
N
Grabo
Daniel
D
Tarola
Nicholas
N
Mericli
Alexander
A
Shapiro
Irving
I
Tulenko
Thomas
T
D017667:Adipocytes / Q000502:physiology*; D000818:Animals; D001672:Biocompatible Materials; D001705:Bioprosthesis; D001807:Blood Vessel Prosthesis; D019917:Blood Vessel Prosthesis Implantation / Q000295:instrumentation*; D018929:Cell Culture Techniques; D002454:Cell Differentiation; D019070:Cell Lineage; D049109:Cell Proliferation; D002478:Cells, Cultured; D042783:Endothelial Cells / Q000502:physiology*; D006801:Humans; D011474:Prosthesis Design; D033581:Stem Cell Transplantation; D013234:Stem Cells / Q000502:physiology*; D023822:Tissue Engineering / Q000379:methods
D001672:Biocompatible Materials