Microwave-assisted synthesis of new polysubstituted dienaminoesters and their cyclization to 3-bromo-2(1H)-pyridinones.
A microwave-assisted, telescoped synthesis, involving a Michael-type addition followed by intramolecular cyclization, provides an effective entry to the polysubstituted 3-bromo-2(1H)-pyridinone core.
Adams
Jeff
J
Chemistry Process Research and Development, Custom Synthesis Laboratory, Amgen Inc., Thousand Oaks, California 91320, USA.
Hardin
Alison
A
Vounatsos
Filisaty
F
D003500:Cyclization; D004952:Esters / Q000138:chemical synthesis* / Q000737:chemistry / Q000528:radiation effects*; D008872:Microwaves; D015394:Molecular Structure; D011728:Pyridones / Q000138:chemical synthesis* / Q000737:chemistry / Q000528:radiation effects*; D013237:Stereoisomerism
D004952:Esters; D011728:Pyridones