Synthesis of peptide ribonucleic acid consisting of D- and L-gamma-glutamic acid as a backbone structure.
A novel nucleic acid model using peptide ribonucleic acid (PRNA), which contains 5-amino-5-deoxyribonucleoside as a recognition site for nucleic acids and consists D-glutamic acid (D-PRNA) instead of L-glutamic acid (L-PRNA) as a backbone structure, has been designed and synthesized. Difference between D-PRNA and L-PRNA oligomers was elucidated on the basis of the effects of chirality of gamma-glutamic acid backbone upon structure elucidated by CD spectra.
Wada
Takehiko
T
PRESTO, JST, Yamada-oka, Suita 565-0871, Japan.
Hashimoto
Yusuke
Y
Sato
Hirofumi
H
Inoue
Yoshihisa
Y
D002021:Buffers; D002942:Circular Dichroism; D018698:Glutamic Acid / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D009690:Nucleic Acid Conformation; D020135:Peptide Nucleic Acids / Q000138:chemical synthesis* / Q000737:chemistry; D012313:RNA / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
D002021:Buffers; D020135:Peptide Nucleic Acids; D018698:Glutamic Acid; D012313:RNA