Spindle cell carcinoma arising in the pharynx, with granulocytosis and high serum granulocyte colony stimulating factor titre.
We report the case of a 67-year-old man with a left pharyngeal tumour, whose peripheral blood showed granulocytosis (white blood cell count, 58,300/microl) and a high serum granulocyte colony stimulating factor titre (184 pg/ml). The tumour showed pleomorphic proliferation of atypical spindle cells in a myxomatous stroma, revealing a sarcomatous pattern. The spindle-shaped neoplastic cells had irregularly shaped nuclei, a thick nuclear membrane, prominent eosinophilic nucleoli and abundant cytoplasm. They strongly expressed wide-spectrum keratin, cytokeratins (CAM5.2, MNF116), vimentin and vascular endothelial growth factor. A few neoplastic cells expressed granulocyte colony stimulating factor. A spindle cell carcinoma was diagnosed. This may be the first documented case of a granulocyte colony stimulating factor producing cancer arising in the pharynx. The patient died four months after the initial symptoms appeared.
Kanayama
R
R
Department of Otorhinopharyngolaryngology, Mito Saiseikai General Hospital, Mito, Ibaraki, Japan.
Oka
K
K
Fukunaga
M
M
Tomisawa
H
H
Takahashi
Y
Y
Okano
M
M
Hakozaki
H
H
D000368:Aged; D002277:Carcinoma / Q000378:metabolism* / Q000473:pathology; D017809:Fatal Outcome; D016179:Granulocyte Colony-Stimulating Factor / Q000378:metabolism*; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D010610:Pharyngeal Neoplasms / Q000378:metabolism* / Q000473:pathology
D016179:Granulocyte Colony-Stimulating Factor