[Clinical application of collagen].
OBJECTIVE
To review and evaluate the extensive and further research and the application of the collagen-based biomaterials in the field of clinical medicine.


METHODS
The clinical research and application of collagen-based biomaterials were comprehensively reviewed and evaluated on the basis of the up-to-date publications and our practical experiences in their studies and manufacturing.


RESULTS
The following five aspects concerned with the collagen-based biomaterials were evaluated: biological property, quality control, formulation of substrate and clinical application, immunogenicity and clinical side effect, and potential of the market development.


CONCLUSIONS
Collagen-based biomaterials have a great potential and market space in their clinical application.
Gu
Qisheng
Q
Shanghai Qisheng Institute of Biomaterial & Technology, PR China. qish@shqisheng.com
D001672:Biocompatible Materials; D003094:Collagen; D006801:Humans
D001672:Biocompatible Materials; D003094:Collagen