title: Benzylamides from Salvadora persica.
abstract: A phytochemical investigation of stems from Salvadora persica resulted in the first isolation of four benzylamides from a natural source. The isolated compounds were identified as butanediamide, N1,N4-bis(phenylmethyl)-2(S)-hydroxy-butanediamide (1), N-benzyl-2-phenylacetamide (2), N-benzylbenzamide (3) and benzylurea (4). The structure elucidation was accomplished using spectroscopic methods, especially 2D NMR and HREIMS. Compound 2 revealed a significant inhibitory effect on human collagen-induced platelet aggregation, and a moderate antibacterial activity against Escherichia coli.
authors.affiliation: Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt. ashraf_khalil2001@yahoo.com
authors.forename: Ashraf Taha
authors.initials: AT
authors.lastname: Khalil
mesh_terms: D000577:Amides / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001593:Benzyl Compounds / Q000737:chemistry*; D003094:Collagen / Q000037:antagonists & inhibitors / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects; D006801:Humans; D066298:In Vitro Techniques; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D018547:Plant Stems / Q000737:chemistry; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology; D032121:Salvadoraceae / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: D000577:Amides; D000900:Anti-Bacterial Agents; D001593:Benzyl Compounds; D007202:Indicators and Reagents; D010975:Platelet Aggregation Inhibitors; D003094:Collagen