A discrete-event approach to transcription control with dynamic event-controllability.
This paper presents a discrete-event approach to the synthesis of transcription control for a class of (computational) gene networks. Given a set of genes and protein-gene and/or protein-protein interaction patterns, this approach can be used to synthesize a transcription control induced by these interaction patterns, and as a consequence, determine the behavior of the gene network. This proposed approach is demonstrated in the synthesis of a transcription control that produces the observed (logical) behavior in the induction of a phage lambda lysogen.
Chen
Peter C Y
PC
Department of Mechanical Engineering, Faculty of Engineering, National University of Singapore, Singapore. mpechenp@nus.edu.sg
D010582:Bacteriophage lambda / Q000235:genetics; D001699:Biometry; D008242:Lysogeny / Q000235:genetics; D008957:Models, Genetic; D015233:Models, Statistical; D014158:Transcription, Genetic