Activity-dependent regulation of BRINP family genes.
We previously identified a family of novel developmentally regulated genes: BRINP1, 2, and 3, which are predominantly and widely expressed in the CNS from earlier developmental stages to adulthood. In the present study, we investigated the activity-dependent regulation of BRINP expression in the CNS. Among the three BRINP genes, BRINP1-mRNA was specifically up-regulated in the dentate gyrus of mouse hippocampus by kainic acid treatment. In cultured hippocampal neurons, the induction of BRINP1-mRNA was also observed by the activation of glutamate receptors. Although BDNF-mRNA is up-regulated in a similar activity-dependent manner, BDNF itself did not induce BRINP1-mRNA. From these results, the physiological roles of the activity-dependent induction of BRINP1-mRNA are discussed.
Motomiya
Makoto
M
Division of Innovative Research, Creative Research Initiative SOUSEI (CRIS), Hokkaido University, Sapporo 001-0021, Japan.
Kobayashi
Miwako
M
Iwasaki
Norimasa
N
Minami
Akio
A
Matsuoka
Ichiro
I
D000818:Animals; D018797:Cell Cycle Proteins; D002478:Cells, Cultured; D005246:Feedback / Q000502:physiology; D005260:Female; D005786:Gene Expression Regulation / Q000502:physiology*; D006624:Hippocampus / Q000166:cytology / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL; D005810:Multigene Family / Q000502:physiology*; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism*; D009474:Neurons / Q000166:cytology / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism; D009435:Synaptic Transmission / Q000502:physiology*
C491992:BRINP1 protein, mouse; D018797:Cell Cycle Proteins; D009419:Nerve Tissue Proteins; D012333:RNA, Messenger