For a healthy histone code, a little SUMO in the tail keeps the acetyl away.
Chemical modification of histones through a growing number of post-translational mechanisms is an integral part of transcription. A recent report provides exciting new evidence that conjugation of the ubiquitin-like protein SUMO to histones opposes acetylation and establishes SUMOylation as an important histone mark linked to transcriptional repression.
Iñiguez-Lluhí
Jorge A
JA
Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan 48109-0632, USA. iniguez@umich.edu
D000107:Acetylation; D000818:Animals; D042421:Histone Code / Q000502:physiology*; D006801:Humans; D025841:Small Ubiquitin-Related Modifier Proteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*
D025841:Small Ubiquitin-Related Modifier Proteins