Fat uses a TOLL-road to connect inflammation and diabetes.
The link between inflammation and diabetes is well established, but the nature of the link is unresolved. Obesity, inflammation, and insulin resistance are major characteristics of diabetes. A study by Flier and colleagues () identifies Toll-like receptor 4 signaling activated by fatty acids as part of that link. This receptor mediates inflammatory events and insulin resistance in peripheral organs.
Kim
Jason K
JK
Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, 500 University Drive (H166), C4600D, Hershey, Pennsylvania 17033, USA.
D000818:Animals; D003920:Diabetes Mellitus / Q000276:immunology*; D005227:Fatty Acids / Q000276:immunology*; D006801:Humans; D007249:Inflammation / Q000276:immunology; D007333:Insulin Resistance / Q000276:immunology*; D009765:Obesity / Q000276:immunology*; D051197:Toll-Like Receptor 4 / Q000276:immunology*
D005227:Fatty Acids; C495345:TLR4 protein, human; D051197:Toll-Like Receptor 4