title: Virological characterization of an infection with a dual-tropic, multidrug-resistant HIV-1 and further evolution on antiretroviral therapy.
abstract: We studied a case of recent infection with multidrug-resistant (MDR) HIV-1. Over 16 months off-therapy, the CD4 cell count decreased from 419 to 184 cells/mul. Antiretroviral therapy (ART) then led to an incomplete virological response but to an immunological benefit, concurrently with a shift to CCR5-only tropism and a reduction in replication capacity. ART, even if suboptimal, can be of interest in the case of MDR virus infection.
authors.affiliation: Department of Virologie et Immunologie Biologique, CHU de Bordeaux, Bordeaux, France.
authors.forename: Bernard
authors.initials: B
authors.lastname: Masquelier
authors.forename: Sophie
authors.initials: S
authors.lastname: Capdepont
authors.forename: Didier
authors.initials: D
authors.lastname: Neau
authors.forename: Olivia
authors.initials: O
authors.lastname: Peuchant
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Taupin
authors.forename: Eoin
authors.initials: E
authors.lastname: Coakley
authors.forename: Yolanda
authors.initials: Y
authors.lastname: Lie
authors.forename: Wassila
authors.initials: W
authors.lastname: Carpentier
authors.forename: François
authors.initials: F
authors.lastname: Dabis
authors.forename: Hervé J A
authors.initials: HJ
authors.lastname: Fleury
mesh_terms: D000328:Adult; D044966:Anti-Retroviral Agents / Q000627:therapeutic use*; D018791:CD4 Lymphocyte Count; D024921:Drug Resistance, Multiple, Viral; D005838:Genotype; D015658:HIV Infections / Q000188:drug therapy* / Q000276:immunology / Q000821:virology; D015497:HIV-1 / Q000235:genetics; D006801:Humans; D008297:Male; D019713:Receptors, CCR5 / Q000378:metabolism; D019562:Viral Load
chemical_list: D044966:Anti-Retroviral Agents; D019713:Receptors, CCR5