beta-catenin destruction complex: insights and questions from a structural perspective.
At the heart of the canonical Wnt signaling pathway is the beta-catenin destruction complex, which functions in the absence of Wnt signaling to keep the cytosolic and nuclear levels of beta-catenin very low by promoting the phosphorylation and ubiquitination of beta-catenin. Structural studies, combined with other experimental approaches, have begun to provide important insights into the mechanism of the destruction complex. We suggest a working model for the destruction complex based on the existing structural and experimental data, and focus on the questions that this model and other studies have raised about the function of the complex in both the normal and Wnt-inhibited states.
Kimelman
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Department of Biochemistry, University of Washington, Seattle, WA 98195-7350, USA. kimelman@u.washington.edu
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D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism; D003110:Colonic Neoplasms / Q000378:metabolism; D003600:Cytosol / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D010766:Phosphorylation; D011487:Protein Conformation; D013234:Stem Cells / Q000378:metabolism; D025801:Ubiquitin / Q000737:chemistry; D051176:beta Catenin / Q000737:chemistry* / Q000502:physiology*
D025801:Ubiquitin; D051176:beta Catenin