Xlf1 is required for DNA repair by nonhomologous end joining in Schizosaccharomyces pombe.
The accurate repair of DNA double-strand breaks is essential for cell survival and maintenance of genome integrity. Here we describe xlf1+, a gene in the fission yeast Schizosaccharomyces pombe that is required for repair of double-strand breaks by nonhomologous end joining during G1 phase of the cell cycle. Xlf1 is the ortholog of budding yeast Nej1 and human XLF/Cernunnos proteins.
Cavero
Santiago
S
Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 90237, USA.
Chahwan
Charly
C
Russell
Paul
P
D000595:Amino Acid Sequence; D004260:DNA Repair / Q000235:genetics*; D016193:G1 Phase; D008969:Molecular Sequence Data; D011995:Recombination, Genetic; D012568:Schizosaccharomyces / Q000235:genetics*; D029702:Schizosaccharomyces pombe Proteins / Q000737:chemistry / Q000235:genetics*; D017385:Sequence Homology
D029702:Schizosaccharomyces pombe Proteins; C519230:XLF1 protein, S pombe