title: Frequent hypermethylation of the DNA repair gene MGMT in long-term survivors of glioblastoma multiforme.
abstract: We have performed a methylation-specific PCR approach to comparatively analyze the MGMT promoter methylation status in 186 glioblastomas (GBM) from patients with classic survival and nine from patients with long-term survival (LTS GBM). The methylation rate in LTS GBM was significantly higher (77.8% vs. 39.2%, P = 0.033) which suggests that MGMT hypermethylation is a frequent hallmark of LTS GBM and contributes to characterize this intriguing GBM subtype.
authors.forename: Ramon
authors.initials: R
authors.lastname: Martinez
authors.forename: Gabriele
authors.initials: G
authors.lastname: Schackert
authors.forename: Ricard
authors.initials: R
authors.lastname: Yaya-Tur
authors.forename: Iñigo
authors.initials: I
authors.lastname: Rojas-Marcos
authors.forename: James G
authors.initials: JG
authors.lastname: Herman
authors.forename: Manel
authors.initials: M
authors.lastname: Esteller
mesh_terms: D000328:Adult; D000368:Aged; D016543:Central Nervous System Neoplasms / Q000235:genetics* / Q000503:physiopathology; D019175:DNA Methylation; D015254:DNA Modification Methylases / Q000235:genetics*; D045643:DNA Repair Enzymes / Q000235:genetics*; D005909:Glioblastoma / Q000235:genetics* / Q000503:physiopathology; D006801:Humans; D008875:Middle Aged; D016019:Survival Analysis; D025521:Tumor Suppressor Proteins / Q000235:genetics*
chemical_list: D025521:Tumor Suppressor Proteins; D015254:DNA Modification Methylases; C515491:MGMT protein, human; D045643:DNA Repair Enzymes