[Use of novel radiation fractionation regimens in organ-sparing therapy of bladder cancer].
The findings of evaluation of complex organ-sparing therapy of 153 patients with invasive bladder cancer are discussed. Transurethral resection of the exophytic end of tumor was followed by two courses of polychemotherapy plus combined treatment. Radiotherapy was carried out by conventional fractionation (group I), hyperfractionation (group II) and accelerated hyperfractionation (group III) (total focal dose--up to 60-66 Gy). Overall and corrected 5-year survival rates were: 47.3 +/- 7.5% and 51.7 +/- 7.5% (group I), 65.6 +/- 1% and 70.4 +/- 8.4% (group II), 53.9% +/- 6.8% and 61.9% +/- 6.8% (group III), respectively. Our tentative results suggest that further efforts be made to improve the efficiency of radiotherapy by introduction of novel techniques.
Gumenetskaia
Iu V
IuV
Gulibov
I A
IA
Kariakin
O B
OB
Popov
A M
AM
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D015653:Cystectomy / Q000379:methods; D019583:Dose Fractionation, Radiation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018714:Radiotherapy, Adjuvant; D016896:Treatment Outcome; D014521:Urethra; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy / Q000532:radiotherapy* / Q000601:surgery