BV/ODV-E26: a palmitoylated, multifunctional structural protein of Autographa californica nucleopolyhedrovirus.
Autographa californica nucleopolyhedrovirus Ac16 is 1 of 17 genes conserved within Type 1 nucleopolyhedroviruses. This report demonstrates that multiple isoforms of the protein encoded by Ac16, BV/ODV-E26 (E26), are present in the infected cell. One form of E26 associates with viral DNA or DNA-binding proteins, while a second form associates with intracellular membranes and this is likely due to palmitoylation. The different forms of E26 present unique epitopes that can be discriminated by antiserum produced to bacterially or virally produced antigen. A summation of the data now available on E26 suggests that it is a multifunctional protein and the functional states assume unique conformations that can be discriminated by differing antisera.
Burks
Jared K
JK
Department of Biology, Texas A&M University, TX, USA.
Summers
Max D
MD
Braunagel
Sharon C
SC
D000595:Amino Acid Sequence; D000818:Animals; D001692:Biological Transport; D002460:Cell Line; D002462:Cell Membrane / Q000378:metabolism; D002467:Cell Nucleus / Q000378:metabolism; D004279:DNA, Viral / Q000096:biosynthesis / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000378:metabolism / Q000502:physiology; D005814:Genes, Viral; D017874:Immediate-Early Proteins / Q000378:metabolism; D008969:Molecular Sequence Data; D017924:Nucleopolyhedroviruses / Q000737:chemistry*; D020033:Protein Isoforms / Q000502:physiology; D016415:Sequence Alignment; D018411:Spodoptera / Q000821:virology; D015534:Trans-Activators / Q000378:metabolism; D014759:Viral Envelope Proteins / Q000378:metabolism; D014764:Viral Proteins / Q000502:physiology*
C069183:Ac-IE-1 protein, Autographa californica nucleopolyhedrovirus; D004279:DNA, Viral; D004268:DNA-Binding Proteins; D017874:Immediate-Early Proteins; D020033:Protein Isoforms; D015534:Trans-Activators; D014759:Viral Envelope Proteins; D014764:Viral Proteins