Regulation and specificity of S-nitrosylation and denitrosylation.
Signal transduction from nitric oxide (NO) is important in physiological processes such as smooth muscle relaxation and neurotransmission. NO signaling occurs through a variety of mechanisms, including S-nitrosylation (SNO) of sulfhydryl groups in protein. A paper in this issue of the journal dissects the regulatory system involved in SNO of caspase-3 and highlights the need for more direct investigations of the complex biological regulation by NO signaling.
Tannenbaum
Steven R
SR
Division of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA. srt@mit.edu
White
Forest M
FM
D000818:Animals; D053148:Caspase 3 / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D008954:Models, Biological; D008956:Models, Chemical; D009130:Muscle, Smooth / Q000378:metabolism; D009474:Neurons / Q000378:metabolism; D009569:Nitric Oxide / Q000737:chemistry*; D009584:Nitrogen / Q000737:chemistry*; D015538:Nitrosation; D026403:S-Nitrosothiols / Q000737:chemistry*; D015398:Signal Transduction
D026403:S-Nitrosothiols; D009569:Nitric Oxide; D053148:Caspase 3; D009584:Nitrogen