title: Osteonecrosis of the jaws in patients with bone metastasis receiving intravenous bisphosphonates. A rising concern.
abstract: Osteonecrosis of the jaws (ONJ) is a recognized complication of bisphosphonates (BP) therapy in cancer patients with bone metastasis. We report 2 additional cases of ONJ in women with breast cancer after long-term exposure to BP, discussing some considerations about the presentation and management of this rare and new complication.
authors.affiliation: Servicio de Oncología Médica, Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, Spain. dagubuj@gobiernodecanarias.org
authors.forename: D
authors.initials: D
authors.lastname: Aguiar Bujanda
authors.forename: M A
authors.initials: MA
authors.lastname: Cabrera Suárez
authors.forename: U
authors.initials: U
authors.lastname: Bohn Sarmiento
authors.forename: S
authors.initials: S
authors.lastname: Quintero Pérez
authors.forename: J
authors.initials: J
authors.lastname: Aguiar Morales
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D050071:Bone Density Conservation Agents / Q000009:adverse effects*; D001859:Bone Neoplasms / Q000188:drug therapy / Q000556:secondary*; D001943:Breast Neoplasms / Q000473:pathology / Q000628:therapy; D003131:Combined Modality Therapy; D004164:Diphosphonates / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007093:Imidazoles / Q000009:adverse effects*; D007571:Jaw Diseases / Q000139:chemically induced*; D008408:Mastectomy; D008875:Middle Aged; D010020:Osteonecrosis / Q000139:chemically induced*; D011878:Radiotherapy; D000077211:Zoledronic Acid
chemical_list: D050071:Bone Density Conservation Agents; D004164:Diphosphonates; D007093:Imidazoles; D000077211:Zoledronic Acid