Environmental risk factors for prevention and molecular intervention of cervical cancer.
Cervical cancer (CC) is potentially the most preventable and treatable cancer in human but it is a leading cause for cancer morbidity and mortality in women around the world. Therefore, more innovative prevention and treatment protocols need to be developed and implemented. With better understanding of the etiology of the disease, specific prevention protocols that involve life-style modifications to minimize the impact of environmental risk factors can be developed. It may be necessary to implement unique modification protocols for different countries. In addition, antiviral vaccine is a highly promising prevention approach. With respect to therapy, the development of more specific protocols that have fewer side effects is needed. With the availability of sophisticated molecular techniques, a new generation of targeted approach that has the potential to generate outstanding efficacy is being tested. Using the siRNA technology against the expression of human papillomavirus oncogenes, specific biological pathways that are essential to the growth and survival of the CC cells can be interrupted. Another promising approach is the molecular intervention of the estrogen pathway by blocking the expression of estrogen receptors. These molecular techniques may work by reactivating endogenous regulatory processes, e.g., the core apoptotic machinery, that can cause self-destruction of the CC cells, thus providing potentially effective molecular therapy. These topics are discussed in this review.
Au
William W
WW
Department of Preventive Medicine and Community Health, The University of Texas Medical Branch, Galveston, TX 77555-1110, USA. Electronic address: william.au@utmb.edu.
Abdou-Salama
Salama
S
Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, TX, USA.
Sierra-Torres
Carlos H
CH
Laboratorio de Genética Humana, Departamento de Ciencias Fisiológicas, Facultad Ciencias de la Salud, Universidad del Cauca, Popayán, Colombia.
Al-Hendy
Ayman
A
Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, TX, USA.
D004777:Environment; D005260:Female; D015316:Genetic Therapy; D006801:Humans; D012307:Risk Factors; D002583:Uterine Cervical Neoplasms / Q000209:etiology* / Q000517:prevention & control / Q000628:therapy