Remission of IgA nephropathy after allogeneic peripheral blood stem cell transplantation followed by immunosuppression for acute lymphocytic leukemia.
We report a case with immunoglobulin A (IgA) nephropathy, showing IgA deposition which disappeared after peripheral blood stem cell transplantation (PBSCT) for acute lymphocytic leukemia (ALL). In 1996, a 28-year-old man was diagnosed with IgA nephropathy by renal biopsy. Steroid therapy improved proteinuria from 3 g/day to 1 g/day. In 2003, he received PBSCT following the initial therapy for ALL. After complete remission, urinary protein and hematuria remained at between (-) and (+/-). In 2004, the second renal biopsy specimen revealed no deposit of IgA or C3. These findings suggested that immune reconstruction with PBSCT following immunosuppression therapy was of benefit to IgA nephropathy.
Iwata
Yasunori
Y
Department of Internal Medicine, Toyama Prefectural Central Hospital, Toyama, Japan.
Wada
Takashi
T
Uchiyama
Akio
A
Miwa
Atsuo
A
Nakaya
Izaya
I
Tohyama
Tadashi
T
Yamada
Yuhji
Y
Kurokawa
Toshiro
T
Yoshida
Takashi
T
Ohta
Satoshi
S
Yokoyama
Hitoshi
H
Iida
Hiroyuki
H
D000328:Adult; D005922:Glomerulonephritis, IGA / Q000150:complications* / Q000473:pathology*; D006801:Humans; D007165:Immunosuppression Therapy; D007668:Kidney / Q000473:pathology; D008297:Male; D036102:Peripheral Blood Stem Cell Transplantation; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000601:surgery*; D012074:Remission Induction