title: Amiodarone pulmonary toxicity: a patient with three recurrences of pulmonary toxicity and consideration of the probable risk for relapse.
abstract: A 44-year-old man was treated with amiodarone for dilated cardiomyopathy. After 53 months, he developed amiodarone-induced interstitial pneumonia. Amiodarone treatment was terminated, and the patient was given corticosteroids. These treatments were effective. However, pneumonitis recurred whenever prednisolone was reduced to less than 5 mg per day. Considering the patient's background characteristics, we considered his body mass index (BMI, kg/m(2)) and found his to be high. When four additional patients with amiodarone pulmonary toxicity were reviewed at our institute, a correlation between BMI and the duration of shadow disappearance was found (R(2)=0.8695). Because amiodarone is lipophilic, the patient's high BMI might have influenced the repeated appearance of pulmonary toxicity.
authors.affiliation: Department of Respiratory Medicine, International Medical Center of Japan, Tokyo, Japan.
authors.forename: Kaori
authors.initials: K
authors.lastname: Okayasu
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Takeda
authors.forename: Jun
authors.initials: J
authors.lastname: Kojima
authors.forename: Atsuto
authors.initials: A
authors.lastname: Yoshizawa
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Kobayashi
authors.forename: Haruhito
authors.initials: H
authors.lastname: Sugiyama
authors.forename: Koichiro
authors.initials: K
authors.lastname: Kudo
mesh_terms: D000328:Adult; D000638:Amiodarone / Q000009:adverse effects* / Q000627:therapeutic use; D000889:Anti-Arrhythmia Agents / Q000009:adverse effects* / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000627:therapeutic use; D015992:Body Mass Index; D002311:Cardiomyopathy, Dilated / Q000188:drug therapy* / Q000473:pathology; D004305:Dose-Response Relationship, Drug; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000188:drug therapy; D008297:Male; D011239:Prednisolone / Q000008:administration & dosage / Q000627:therapeutic use; D013902:Radiography, Thoracic; D012008:Recurrence; D019233:Retreatment; D014057:Tomography, X-Ray Computed
chemical_list: D000889:Anti-Arrhythmia Agents; D000893:Anti-Inflammatory Agents; D011239:Prednisolone; D000638:Amiodarone