Novel numerical and graphical representation of DNA sequences and proteins.
We have introduced novel numerical and graphical representations of DNA, which offer a simple and unique characterization of DNA sequences. The numerical representation of a DNA sequence is given as a sequence of real numbers derived from a unique graphical representation of the standard genetic code. There is no loss of information on the primary structure of a DNA sequence associated with this numerical representation. The novel representations are illustrated with the coding sequences of the first exon of beta-globin gene of half a dozen species in addition to human. The method can be extended to proteins as is exemplified by humanin, a 24-aa peptide that has recently been identified as a specific inhibitor of neuronal cell death induced by familial Alzheimer's disease mutant genes.
Randić
M
M
National Institute of Chemistry, P.O. Box 3430, 1001 Ljubljana, Slovenia. mrandic@msn.com
Novic
M
M
Vikić-Topić
D
D
Plavsić
D
D
D016923:Cell Death; D003062:Codon; D019295:Computational Biology / Q000379:methods; D003196:Computer Graphics; D004247:DNA / Q000737:chemistry; D005091:Exons; D005914:Globins / Q000235:genetics; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000737:chemistry; D008962:Models, Theoretical; D009474:Neurons / Q000378:metabolism; D017422:Sequence Analysis, DNA / Q000379:methods*; D020539:Sequence Analysis, Protein / Q000379:methods*
D003062:Codon; D047908:Intracellular Signaling Peptides and Proteins; C427211:humanin; D005914:Globins; D004247:DNA