A graphical approach to relatedness inference.
The estimation of relatedness structure in natural populations using molecular marker data has become an important tool in population biology, resulting in a variety of estimation procedures for specific sampling scenarios. In this article a general approach is proposed, in which the detailed relationship structure, typically a pedigree graph or partition, is considered to be the object of inference. This makes available tools used in complex model selection theory which have demonstrated effectiveness. An important advantage of this approach is that it permits a fully Bayesian approach to the problem, providing a principled and accessible way to measure statistical error. The approach is demonstrated by applying the minimum description length principle. This technique is used in model selection to provide a rational way of comparing models of varying complexity. We show how the resulting score may be interpreted and applied as a Bayesian posterior density.
Almudevar
Anthony
A
Department of Biostatistics and Computational Biology, University of Rochester, Rochester, NY 14642, USA. anthony_almudevar@urmc.rochester.edu
D001499:Bayes Theorem; D003198:Computer Simulation; D006801:Humans; D008433:Mathematics; D008954:Models, Biological; D010375:Pedigree; D011156:Population Density; D011157:Population Dynamics