title: New findings from the Bipolar Collaborative Network: clinical implications for therapeutics.
abstract: In this article, we highlight recent Bipolar Collaborative Network data. We found that childhood-onset bipolar illness is common, often goes untreated for more than a decade, and carries a poor prognosis. During randomized studies of adjunctive medications in depression: 1) Venlafaxine showed higher switch rates than bupropion or sertraline; 2) Tranylcypromine was as well tolerated as lamotrigine; and 3) Modafinil was more effective than placebo. Finally, in treatment of overweight and obesity, topiramate and sibutramine showed equal efficacy but poor tolerability, and zonisamide data showed that it may be useful for mood and weight loss.
authors.affiliation: Penn State College of Medicine, Hershey, PA, USA. robert.post@speakeasy.net
authors.forename: Robert M
authors.initials: RM
authors.lastname: Post
authors.forename: Lori L
authors.initials: LL
authors.lastname: Altshuler
authors.forename: Mark A
authors.initials: MA
authors.lastname: Frye
authors.forename: Trisha
authors.initials: T
authors.lastname: Suppes
authors.forename: Susan
authors.initials: S
authors.lastname: McElroy
authors.forename: Paul E
authors.initials: PE
authors.lastname: Keck
authors.forename: Gabriele S
authors.initials: GS
authors.lastname: Leverich
authors.forename: Ralph
authors.initials: R
authors.lastname: Kupka
authors.forename: Willem A
authors.initials: WA
authors.lastname: Nolen
authors.forename: Heinz
authors.initials: H
authors.lastname: Grunze
mesh_terms: D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects / Q000627:therapeutic use*; D000928:Antidepressive Agents / Q000009:adverse effects / Q000627:therapeutic use*; D018692:Antimanic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001714:Bipolar Disorder / Q000175:diagnosis / Q000188:drug therapy* / Q000523:psychology; D002648:Child; D003865:Major Depressive Disorder / Q000175:diagnosis / Q000188:drug therapy / Q000523:psychology; D003937:Diagnosis, Differential; D006801:Humans; D011379:Prognosis
chemical_list: D000927:Anticonvulsants; D000928:Antidepressive Agents; D018692:Antimanic Agents