Adult stem cell therapy: dream or reality?
Adult stem cells may be an invaluable source of plastic cells for tissue regeneration. The bone marrow contains different subpopulations of adult stem cells easily accessible for transplantation. However the therapeutic value of adult stem cell is a question of debate in the scientific community. We have investigated the potential benefits of adult hematopoietic stem cell transplantation in animal models of demyelinating and motor neuron diseases. Our results suggest that transplantation of HSC have direct and indirect neuroregenerative and neuroprotective effects.
Moraleda
Jose M
JM
Hospital Morales Meseguer, Servicio de Hematología, Facultad de Medicina, Murcia, Spain. jmoraled@um.es
Blanquer
Miguel
M
Bleda
Patricia
P
Iniesta
Paqui
P
Ruiz
Francisco
F
Bonilla
Sonia
S
Cabanes
Carmen
C
Tabares
Lucía
L
Martinez
Salvador
S
D000818:Animals; D003711:Demyelinating Diseases / Q000628:therapy; D018380:Hematopoietic Stem Cell Transplantation / Q000639:trends*; D006801:Humans; D051379:Mice; D016472:Motor Neuron Disease / Q000628:therapy; D009416:Nerve Regeneration; D009422:Nervous System Diseases / Q000628:therapy*; D019636:Neurodegenerative Diseases / Q000628:therapy