title: Stereoselective synthesis of methyl monate C.
abstract: [Structure: see text] The stereoselective synthesis of methyl monate C 2 is described using as a key step an ene-intramolecular modified Sakurai cyclization (IMSC) reaction to prepare tetrahydropyran 5. An asymmetric allylic alkylation, followed by a cross-metathesis, enables the insertion of the right-hand side chain.
authors.affiliation: Université Catholique de Louvain, Département de Chimie, Bâtiment Lavoisier, Place Louis Pasteur 1, B-1348 Louvain-la-Neuve, Belgium.
authors.forename: Livia
authors.initials: L
authors.lastname: van Innis
authors.forename: Jean Marc
authors.initials: JM
authors.lastname: Plancher
authors.forename: István E
authors.initials: IE
authors.lastname: Markó
mesh_terms: D000478:Alkylation; D007700:Kinetics; D016712:Mupirocin / Q000138:chemical synthesis*; D013237:Stereoisomerism
chemical_list: D016712:Mupirocin