title: Hydrogen bond removal of pterin derivative whose structure is similar to nucleic acid bases.
abstract: Pterin, an analog of guanine, is an electron transfer compound in biological systems. Among the analogs, 6-formylpterin (6FP) has been demonstrated to have many marked physiological and pharmacological activities and it is, therefore, worthwhile to elucidate whole mechanism of its activities. Unfortunately, however, 6FP is hardly soluble in water and organic solvents. Like nucleic acid bases, 6FP makes intermolecular hydrogen bonds and forms stacking structure causing such drawback nature. This has made mechanistic studies on 6FP activities extremely difficult. In this study, we carried out derivatization for 6FP and succeeded in increasing water solubility with maintaining its physiological activities.
authors.affiliation: Institute of Advanced Energy, Kyoto University, Uji 611-0011, Japan.
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Nonogawa
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Arai
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Endo
authors.forename: Seung Pil
authors.initials: SP
authors.lastname: Pack
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Kodaki
authors.forename: Keisuke
authors.initials: K
authors.lastname: Makino
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry*; D045744:Cell Line, Tumor; D006147:Guanine / Q000737:chemistry; D006801:Humans; D006860:Hydrogen Bonding; D011622:Pterins / Q000737:chemistry*; D012995:Solubility; D014867:Water / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D011622:Pterins; D014867:Water; D006147:Guanine; C005926:2-amino-4-hydroxy-6-formylpteridine