[Experimental study on anti-tumor effect of extractive from Celastrus orbiculatus in vivo].
OBJECTIVE
To study the anti-tumor activity of extractive from Celastrus orbiculatus in vivo.


METHODS
Mice bearing transplanted tumor S180 and Heps were used to study the effects of acetoacetate and n-butanol extractive from C. orbiculatus. The changes in serum contents of SOD and malondialdehyde (MDA) content were assayed.


RESULTS
Acetoacetate and n-butanol extractive from C. orbiculatus significantly inhibited the growth of S180 and Heps tumor in mice. SOD content was obviously increased, MDA content obviously decreased in the serum after extractive treatment.


CONCLUSIONS
Acetoacetate and n-butanol extractive from C. orbiculatus have anti-tumor effects and anti-oxidative capacity.
Zhang
Jian
J
Medical School of Yangzhou University, Yangzhou 225001, China.
Xu
Yun-Ming
YM
Wang
Wei-Min
WM
Liu
Yan-Qing
YQ
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology*; D000975:Antioxidants / Q000302:isolation & purification / Q000494:pharmacology; D031247:Celastrus / Q000737:chemistry; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D005260:Female; D008114:Liver Neoplasms, Experimental / Q000097:blood / Q000473:pathology; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D051379:Mice; D008813:Mice, Inbred ICR; D009368:Neoplasm Transplantation; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D012510:Sarcoma 180 / Q000097:blood / Q000473:pathology*; D013482:Superoxide Dismutase / Q000097:blood
D000972:Antineoplastic Agents, Phytogenic; D000975:Antioxidants; D004365:Drugs, Chinese Herbal; D008315:Malondialdehyde; D013482:Superoxide Dismutase