[Liver damage in treatment of latent tuberculous infection by isoniazid].
OBJECTIVE
To study the frequency and degree of liver damage as adverse effect of isoniazid (INH) preventive therapy in Japanese people.


OBJECTIVE
Chart review of Japanese persons who started isoniazid preventive chemotherapy in the two clinics in Tokyo, from 2003/1/1 to 2004/12/31.


RESULTS
There were 779 cases who did not transiently or completely stop INH preventive therapy because of adverse effect, and 26 cases who stopped INH transiently or completely because of liver damage as adverse effect (total 805 cases). In 371 cases, of those 779 cases, AST (asparate aminotransferase) and ALT (alanine aminotransferase) was measured after starting INH at least once. In 14.9% (59/397) of these 391 cases (= 371 + 26), liver damage as adverse effect was found. In 1.51% (6/397), liver damage with AST and/or ALT higher than 400 IU/L was found. Clinical hepatitis, associated with clinical symptom of hepatitis, was seen in 0.37% (3/805). Hepatitis with liver failure was seen in 0.12%. There was no death due to liver damage.


CONCLUSIONS
Liver damage as adverse effect of isoniazid (INH) preventive therapy in Japanese people is not rare.
Ito
Kunihiko
K
Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association (JATA). ito@jata.or.jp
Hoshino
Hitoshi
H
Nakazono
Tomoaki
T
Masuyama
Hidenori
H
Sugita
Hironobu
H
Yoshiyama
Takashi
T
Kato
Seiya
S
D000293:Adolescent; D000328:Adult; D000995:Antitubercular Agents / Q000009:adverse effects*; D044466:Asian People; D056486:Chemical and Drug Induced Liver Injury; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D007538:Isoniazid / Q000009:adverse effects*; D007564:Japan / Q000453:epidemiology; D008107:Liver Diseases / Q000175:diagnosis / Q000453:epidemiology; D014376:Tuberculosis / Q000517:prevention & control*
D000995:Antitubercular Agents; D007538:Isoniazid