title: Building addressable libraries: The use of a mass spectrometry cleavable linker for monitoring reactions on a microelectrode array.
abstract: Time-of-flight secondary ion mass spectrometry (TOF SIMS) has been used in conjunction with a mass spectrometry cleavable linker to determine the percent conversion of reactions that were conducted site-selectively on an addressable microelectrode array. When combined with fluorescence techniques for analysis of the reactions, the TOF SIMS experiment provides a means for optimization of both reaction confinement and reaction efficiency on the microelectrode arrays.
authors.affiliation: Department of Chemistry, Washington University, St. Louis, Missouri 63130, USA.
authors.forename: Ceng
authors.initials: C
authors.lastname: Chen
authors.forename: Gabriella
authors.initials: G
authors.lastname: Nagy
authors.forename: Amy V
authors.initials: AV
authors.lastname: Walker
authors.forename: Karl
authors.initials: K
authors.lastname: Maurer
authors.forename: Andy
authors.initials: A
authors.lastname: McShea
authors.forename: Kevin D
authors.initials: KD
authors.lastname: Moeller
mesh_terms: D002138:Calibration; D003432:Cross-Linking Reagents / Q000737:chemistry*; D016208:Databases, Factual; D004566:Electrodes; D013058:Mass Spectrometry / Q000379:methods*; D046228:Microarray Analysis / Q000379:methods*; D015394:Molecular Structure; D010084:Oxidation-Reduction
chemical_list: D003432:Cross-Linking Reagents