Selection of RNA-aptamer against human influenza B virus.
Developing specific probes that distinguishes types and subtypes of viruses by a single probe will have a great impact not only in developing specific diagnostic reagents but also in developing tailor-made drugs and dosage requirements depending upon the genotype that cause the infection. We have selected aptamers specific for hemagglutinin protein of human influenza virus B/Johannesburg/05/1999. The selected aptamer, Class A-20, bind specifically to hemagglutinin of B/Johannesburg/05/1999 and able to discriminate it from hemagglutinin of human influenza A virus.
Gopinath
Subash C B
SC
Institute for Biological Resources and Functions, National Institute of Advanced Industrial Science and Technology, Central 6, 1-1 Higashi, Tsukuba City 305-8566 Ibaraki, Japan.
Kawasaki
Kazunori
K
Kumar
Penmetcha K R
PK
D052157:Aptamers, Nucleotide; D019267:Hemagglutinin Glycoproteins, Influenza Virus / Q000032:analysis*; D006801:Humans; D009981:Influenza B virus / Q000145:classification*; D015345:Oligonucleotide Probes; D052156:SELEX Aptamer Technique
D052157:Aptamers, Nucleotide; D019267:Hemagglutinin Glycoproteins, Influenza Virus; D015345:Oligonucleotide Probes; C109963:hemagglutinin, avian influenza A virus