Studies on the alkaloid constituents of Evodia rutaecarpa (Juss) Benth var. bodinaieri (Dode) Huang and their acute toxicity in mice.
Six alkaloids (1-6) have been isolated from the fruits of Evodia rutaecarpa (Juss) Benth var. bodinaieri (Dode) Huang, two of which are new compounds, identified as 2-undecyl-4(1H)-quinolone (4) and 1-methyl-2-undecanone-10'-4(1H)-quinolone (5); the known compounds were identified as rutaecarpine (1), evodiamine (2), 1-methyl-2-undecyl-4(1H)-quinoline (3) and 2-undecanone-10'-4(1H)-quinolone (6). Compounds 1-5 were evaluated for their acute toxicity.
Yang
X-W
XW
State Key Laboratory of Natural & Biomimetic Drugs, School of Pharmaceutical Sciences, and Medical and Healthy Analysis Center, Peking University, Beijing, 100083, China. xwyang@mail.bjmu.edu.cn
Zhang
H
H
Li
M
M
Du
L-J
LJ
Yang
Z
Z
Xiao
S-Y
SY
D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D000818:Animals; D000431:Ethanol; D032086:Evodia / Q000737:chemistry*; D005638:Fruit / Q000737:chemistry*; D007928:Lethal Dose 50; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry; D011804:Quinolines / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D013053:Spectrophotometry; D023382:Toxicity Tests, Acute
C517910:1-methyl-2-undecanone-10'-4(1H)-quinolone; C517911:2-undecyl-4(1H)-quinolone; D000470:Alkaloids; D010936:Plant Extracts; D011804:Quinolines; D000431:Ethanol