Stereoselective synthesis of methyl monate C.
[Structure: see text] The stereoselective synthesis of methyl monate C 2 is described using as a key step an ene-intramolecular modified Sakurai cyclization (IMSC) reaction to prepare tetrahydropyran 5. An asymmetric allylic alkylation, followed by a cross-metathesis, enables the insertion of the right-hand side chain.
van Innis
Livia
L
Université Catholique de Louvain, Département de Chimie, Bâtiment Lavoisier, Place Louis Pasteur 1, B-1348 Louvain-la-Neuve, Belgium.
Plancher
Jean Marc
JM
Markó
István E
IE
D000478:Alkylation; D007700:Kinetics; D016712:Mupirocin / Q000138:chemical synthesis*; D013237:Stereoisomerism
D016712:Mupirocin