title: Mycobacterium tuberculosis triggers formation of lymphoid structure in murine lungs.
abstract: The hallmark of pulmonary tuberculosis is the granuloma, which consists predominantly of lymphocytes and macrophages and promotes immune-cell interaction with the causative pathogen, Mycobacterium tuberculosis. Granuloma formation is a highly organized process, which depends on leukocyte recruitment facilitated by adhesion molecules and chemokines. Thus, during chronic experimental tuberculosis, granulomata display characteristics of lymphoid structures comprising follicular aggregation of B cells, formation of high endothelial venules, presence of follicular dendritic cells, and expression of the homeostatic chemokines CXCL13 and CCL19. CCR7-/- mice, which are deficient in CCL19 and CCL21 signaling, exhibit increased local inflammatory infiltrates but no follicular B-cell aggregation within those lymphoid structures. However, CCR7-deficient mice are fully capable to control pulmonary tuberculosis; at time points later than 6 weeks postinfection, they carry a lower bacterial load in peripheral organs. Our results show that, during chronic pulmonary tuberculosis in mice, the homeostatic chemokine signaling-network contributes to spatial organization of the granulomatous response, which participates in both containment of M. tuberculosis and the latter's dissemination to other organs.
authors.affiliation: Department of Immunology, Max Planck Institute for Infection Biology, D-10117 Berlin, Germany.
authors.forename: Antje
authors.initials: A
authors.lastname: Kahnert
authors.forename: Uta E
authors.initials: UE
authors.lastname: Höpken
authors.forename: Maik
authors.initials: M
authors.lastname: Stein
authors.forename: Silke
authors.initials: S
authors.lastname: Bandermann
authors.forename: Martin
authors.initials: M
authors.lastname: Lipp
authors.forename: Stefan H E
authors.initials: SH
authors.lastname: Kaufmann
mesh_terms: D000818:Animals; D008168:Lung / Q000276:immunology / Q000382:microbiology* / Q000473:pathology*; D051379:Mice; D008807:Mice, Inbred BALB C; D009169:Mycobacterium tuberculosis / Q000276:immunology*; D014376:Tuberculosis / Q000276:immunology / Q000382:microbiology / Q000473:pathology*