Central pontine myelinolysis after liver transplantation: MR diffusion, spectroscopy and perfusion findings.
Magnetic resonance spectroscopy (MRS) and perfusion of central pontine myelinolysis (CPM) have been rarely reported. One case of CPM that developed after liver transplantation was analyzed with serial diffusion-weighted imaging (DWI), MRS and MR perfusion. During the acute phase, a pontine lesion showed an obvious high-signal intensity on DWI with decreased apparent diffusion coefficient value, decreased N-acetylaspartate (NAA)/creatine (Cr) ratio, increased choline (Cho)/Cr ratio and increased perfusion on the cerebral blood volume map. In a later phase, the lesion showed isosignal intensity on DWI, further decreased NAA/Cr ratio, increased Cho/Cr ratio and decreased perfusion. The increase in lesion perfusion during the acute phase may reflect a higher metabolic activity due to an increase in cell number and activity.
Guo
Yong
Y
Department of Radiology, General Navy Hospital, Beijing, China. guoyong27@hotmail.com
Hu
Jin-Hua
JH
Lin
Wei
W
Zheng
Kui-Hong
KH
D000328:Adult; D038524:Diffusion Magnetic Resonance Imaging; D006801:Humans; D016031:Liver Transplantation / Q000009:adverse effects*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D017590:Myelinolysis, Central Pontine / Q000175:diagnosis* / Q000209:etiology