title: Biologically active oxidized lipids (phytoprostanes) in the plant diet and parenteral lipid nutrition.
abstract: Phytoprostanes (PP) are autoxidation products of alpha-linolenate that are present in all plant tissues. Several classes of PP with a prostaglandin (PG) F1-, E1-, A1- and B1-like structure were identified and quantified by gas chromatography-mass spectrometry in vegetable oils and parenteral nutrition (intralipid). High levels of PP (0.09 up to 99 mg/l) were found even in apparently fresh vegetable oils. After oral consumption of olive or soybean oil, PPF1 were absorbed, found to circulate in plasma in conjugated form and excreted in free form into urine. Evidence is emerging that certain PP, such as the PPE1, may modulate the function of immune cells in a PG-like fashion. Here, we show that PPA1- and deoxy-PPJ1 display potent anti-inflammatory and apoptosis inducing activities similar to PGA1 and deoxy-PGJ2. Results of this study indicate that PP are novel, biologically active lipids in plant nutrition.
authors.affiliation: Julius-von-Sachs-Institute for Biosciences, Pharmaceutical Biology, University of Wuerzburg, Julius-von-Sachs-Platz 2, D-97082, Wuerzburg, Germany.
authors.forename: Kathrin
authors.initials: K
authors.lastname: Karg
authors.forename: Verena M
authors.initials: VM
authors.lastname: Dirsch
authors.forename: Angelika M
authors.initials: AM
authors.lastname: Vollmar
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Cracowski
authors.forename: François
authors.initials: F
authors.lastname: Laporte
authors.forename: Martin J
authors.initials: MJ
authors.lastname: Mueller
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D003517:Cyclopentanes / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D005217:Fat Emulsions, Intravenous / Q000737:chemistry; D005231:Fatty Acids, Unsaturated / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D006801:Humans; D019169:Jurkat Cells; D008297:Male; D013058:Mass Spectrometry; D051379:Mice; D009569:Nitric Oxide / Q000378:metabolism; D010288:Parenteral Nutrition; D010938:Plant Oils / Q000737:chemistry* / Q000378:metabolism*
chemical_list: D003517:Cyclopentanes; D005217:Fat Emulsions, Intravenous; D005231:Fatty Acids, Unsaturated; D010938:Plant Oils; D009569:Nitric Oxide