Preparation of thin polymer films with drug release and protein adsorption resistance.
Thin polymer films with the ability of both drug release and protein adsorption resistance were formed on silicon substrates and silica particles. The films were made of a block copolymer of poly(N-isopropylacrylamide) (p(AAm)) that can load and release drugs and poly(2-methoxyethyl methacrylate) (p(MEMA)) that can suppress protein adsorption. Aspirin and bovine serum albumin were respectively used as model substances for testing the abilities of the films to load and release drugs and to suppress protein adsorption. The films were immersed in a phosphate buffer saline (pH 7.4) for 100 days to evaluate their water resistance. The experimental results showed that the films have both drug release and protein adsorption resistance and are highly stable against PBS.
Tsukagoshi
Tatsuya
T
Department of Industrial Chemistry, Faculty of Engineering, Tokyo University of Science, 12-1 Ichigaya-Funagawara, Shinjuku-ku, Tokyo 162-0826, Japan.
Kondo
Yukishige
Y
Yoshino
Norio
N
D000180:Acrylic Resins / Q000737:chemistry*; D000327:Adsorption; D001241:Aspirin / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D004339:Drug Compounding / Q000379:methods; D004355:Drug Stability; D008567:Membranes, Artificial; D015394:Molecular Structure; D010316:Particle Size; D011109:Polymethacrylic Acids / Q000737:chemistry*; D012710:Serum Albumin, Bovine / Q000737:chemistry*; D012825:Silicon / Q000737:chemistry; D012822:Silicon Dioxide / Q000737:chemistry; D013499:Surface Properties
D000180:Acrylic Resins; D004337:Drug Carriers; D008567:Membranes, Artificial; D011109:Polymethacrylic Acids; C518842:poly(2-methoxyethyl methacrylate); C052970:poly-N-isopropylacrylamide; D012710:Serum Albumin, Bovine; D012822:Silicon Dioxide; D001241:Aspirin; D012825:Silicon