Discovery of selective irreversible inhibitors for Bruton's tyrosine kinase.
Pan
Zhengying
Z
Department of Medicinal Chemistry, Celera Genomics, 180 Kimball Way, South San Francisco, CA 94080, USA. zypan@yahoo.com
Scheerens
Heleen
H
Li
Shyr-Jiann
SJ
Schultz
Brian E
BE
Sprengeler
Paul A
PA
Burrill
L Chuck
LC
Mendonca
Rohan V
RV
Sweeney
Michael D
MD
Scott
Keana C K
KC
Grothaus
Paul G
PG
Jeffery
Douglas A
DA
Spoerke
Jill M
JM
Honigberg
Lee A
LA
Young
Peter R
PR
Dalrymple
Stacie A
SA
Palmer
James T
JT
D000255:Adenosine Triphosphate / Q000378:metabolism; D000077329:Agammaglobulinaemia Tyrosine Kinase; D000595:Amino Acid Sequence; D000818:Animals; D018501:Antirheumatic Agents / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000188:drug therapy / Q000201:enzymology; D001665:Binding Sites; D004195:Disease Models, Animal; D015195:Drug Design; D008969:Molecular Sequence Data; D009842:Oligopeptides / Q000737:chemistry / Q000378:metabolism; D047428:Protein Kinase Inhibitors / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D011505:Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D012377:Rodentia; D013329:Structure-Activity Relationship
D018501:Antirheumatic Agents; D009842:Oligopeptides; D047428:Protein Kinase Inhibitors; D000255:Adenosine Triphosphate; D011505:Protein-Tyrosine Kinases; D000077329:Agammaglobulinaemia Tyrosine Kinase