title: Discovery of selective irreversible inhibitors for Bruton's tyrosine kinase.
authors.affiliation: Department of Medicinal Chemistry, Celera Genomics, 180 Kimball Way, South San Francisco, CA 94080, USA. zypan@yahoo.com
authors.forename: Zhengying
authors.initials: Z
authors.lastname: Pan
authors.forename: Heleen
authors.initials: H
authors.lastname: Scheerens
authors.forename: Shyr-Jiann
authors.initials: SJ
authors.lastname: Li
authors.forename: Brian E
authors.initials: BE
authors.lastname: Schultz
authors.forename: Paul A
authors.initials: PA
authors.lastname: Sprengeler
authors.forename: L Chuck
authors.initials: LC
authors.lastname: Burrill
authors.forename: Rohan V
authors.initials: RV
authors.lastname: Mendonca
authors.forename: Michael D
authors.initials: MD
authors.lastname: Sweeney
authors.forename: Keana C K
authors.initials: KC
authors.lastname: Scott
authors.forename: Paul G
authors.initials: PG
authors.lastname: Grothaus
authors.forename: Douglas A
authors.initials: DA
authors.lastname: Jeffery
authors.forename: Jill M
authors.initials: JM
authors.lastname: Spoerke
authors.forename: Lee A
authors.initials: LA
authors.lastname: Honigberg
authors.forename: Peter R
authors.initials: PR
authors.lastname: Young
authors.forename: Stacie A
authors.initials: SA
authors.lastname: Dalrymple
authors.forename: James T
authors.initials: JT
authors.lastname: Palmer
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D000077329:Agammaglobulinaemia Tyrosine Kinase; D000595:Amino Acid Sequence; D000818:Animals; D018501:Antirheumatic Agents / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000188:drug therapy / Q000201:enzymology; D001665:Binding Sites; D004195:Disease Models, Animal; D015195:Drug Design; D008969:Molecular Sequence Data; D009842:Oligopeptides / Q000737:chemistry / Q000378:metabolism; D047428:Protein Kinase Inhibitors / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D011505:Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D012377:Rodentia; D013329:Structure-Activity Relationship
chemical_list: D018501:Antirheumatic Agents; D009842:Oligopeptides; D047428:Protein Kinase Inhibitors; D000255:Adenosine Triphosphate; D011505:Protein-Tyrosine Kinases; D000077329:Agammaglobulinaemia Tyrosine Kinase