title: Serious complications after radiosynoviorthesis. Survey on frequency and treatment modalities.
abstract: OBJECTIVE
  Radiosynoviorthesis using intraarticular injection of beta-emitting radiocolloids is increasingly performed throughout Europe in patients with inflammatory joint disease. It is a cost-effective and safe treatment, local complications are very rare with only eight cases mentioned in the literature so far. No recommendations for therapy of tissue necrosis, infection or thromboembolism after radiosynoviorthesis are available.
  
  
  METHODS
  Using a standardized questionary, 260 nuclear medicine physicians and 20 medical liability insurances were asked for the kind and frequency of complications after radiosynoviorthesis between 1998 and 2003. The survey was terminated after nine months with a response of only 25.7%.
  
  
  RESULTS
  A total of 53 severe complications were documented (28 necroses, 12 thromboses, 13 joint infections). Eight other complications were seen but difficult to correlate directly with radiosynoviorthesis. Tissue necroses from yttrium-90 were successfully treated by surgical excision and closure of the defect. Rhenium-186-induced ulcers healed by hyperbaric oxygen therapy in two cases. Lesions from erbium-169 showed restoration by conservative treatment. Thromboembolic events happened after radiosynoviorthesis in joints of the lower limb only, mostly treated by conventional anticoagulation. Intraarticular infections showed restoration after intraarticular antibiotics in the majority of cases.
  
  
  CONCLUSIONS
  Severe complications after radiosynoviorthesis seem to be rare. However, because of the low return rate, a reliable frequency cannot be calculated. Nevertheless, important advices regarding treatment concepts can be taken from our data.
authors.affiliation: Clinic of Nuclear Medicine, University Hospital Schleswig-Holstein, Campus Kiel, Arnold-Heller-Str. 9, 24105 Kiel, Germany. ukampen@nuc-med.uni-kiel.de
authors.forename: W U
authors.initials: WU
authors.lastname: Kampen
authors.forename: E
authors.initials: E
authors.lastname: Matis
authors.forename: N
authors.initials: N
authors.lastname: Czech
authors.forename: Z
authors.initials: Z
authors.lastname: Soti
authors.forename: S
authors.initials: S
authors.lastname: Gratz
authors.forename: E
authors.initials: E
authors.lastname: Henze
mesh_terms: D006801:Humans; D007596:Joints / Q000000981:diagnostic imaging*; D007719:Knee Joint / Q000528:radiation effects; D011832:Radiation Injuries / Q000453:epidemiology; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000009:adverse effects* / Q000627:therapeutic use*; D011879:Radiotherapy Dosage; D012867:Skin / Q000528:radiation effects; D013583:Synovial Membrane / Q000000981:diagnostic imaging*
chemical_list: D019275:Radiopharmaceuticals