title: A case of HHV-6 associated acute necrotizing encephalopathy with increase of CD56bright NKcells.
abstract: We describe a 15-month-old girl with acute necrotizing encephalopathy (ANE) associated with HHV-6. Inflammatory cytokines were elevated in the CSF and serum and the number of CD56bright NK cells was significantly increased in the peripheral blood. CD56bright NK cells may be involved in the pathogenesis of ANE by producing inflammatory cytokines.
authors.affiliation: Department of Pediatrics, National Defense Medical College, Saitama, Japan. bokukubo17@hotmail.com
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Kubo
authors.forename: Kengo
authors.initials: K
authors.lastname: Sato
authors.forename: Daisuke
authors.initials: D
authors.lastname: Kobayashi
authors.forename: Akira
authors.initials: A
authors.lastname: Motegi
authors.forename: Osamu
authors.initials: O
authors.lastname: Kobayashi
authors.forename: Seiichirou
authors.initials: S
authors.lastname: Takeshita
authors.forename: Shigeaki
authors.initials: S
authors.lastname: Nonoyama
mesh_terms: D001927:Brain Diseases / Q000150:complications / Q000276:immunology / Q000821:virology*; D019002:CD56 Antigen / Q000276:immunology; D016207:Cytokines / Q000097:blood / Q000134:cerebrospinal fluid; D005260:Female; D015654:Herpesvirus 6, Human / Q000276:immunology / Q000472:pathogenicity*; D006801:Humans; D007074:Immunoglobulin G / Q000134:cerebrospinal fluid; D007223:Infant; D007694:Killer Cells, Natural / Q000276:immunology; D009336:Necrosis / Q000821:virology; D019349:Roseolovirus Infections / Q000150:complications / Q000276:immunology / Q000821:virology*
chemical_list: D019002:CD56 Antigen; D016207:Cytokines; D007074:Immunoglobulin G