title: Review of radiosurgery of pineal parenchymal tumors. Long survival following 125-iodine brachytherapy of pineoblastomas in 2 cases.
abstract: OBJECTIVE
  The aim of the present work is to report the volumetric changes of tumor in two pineoblastoma patients treated with stereotactic interstitial irradiation and to present a review on radiosurgery of pineal parenchymal tumors.
  
  
  METHODS
  Two of our patients with pineoblastoma were treated with CT and image-fusion guided 125-iodine brachytherapy. The tumor volumes were determined with outlined contours on planning and control CT/MRI images and were compared.
  
  
  RESULTS
  Until January 2006, there were 61- and 58-month follow-up periods in the two cases. 56 and 53 months after irradiation the MRI images showed significant tumor shrinkage. In case 1 tumor volume was 0.76 cm (3) on the last control MRI image, compared to the 2.87 cm (3) at the time of interstitial irradiation, which means 73% shrinkage. In case 2, tumor volume measured with the last control MRI examination was 0.29 cm (3), which represents 77% shrinkage of the original tumor volume. In both Cases 1 and 2, PET examinations using (11)C-methionine showed no active tumor mass 56 and 53 months following brachytherapy.
  
  
  CONCLUSIONS
  Two successful treatments of pineoblastoma are reported. The interstitial irradiation of the tumors decreased their volumes significantly. The CT and image fusion-guided 125-iodine stereotactic brachytherapy can be planned well dosimetrically and is surgically precise.
authors.affiliation: St. John's Hospital Department of Neurosurgery, Budapest, Hungary. h1249jul@ellaa.hu
authors.forename: J
authors.initials: J
authors.lastname: Julow
authors.forename: A
authors.initials: A
authors.lastname: Viola
authors.forename: T
authors.initials: T
authors.lastname: Major
mesh_terms: D000368:Aged; D001706:Biopsy; D001918:Brachytherapy / Q000379:methods*; D001932:Brain Neoplasms / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery*; D002250:Carbon Radioisotopes; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use*; D008279:Magnetic Resonance Imaging; D008715:Methionine; D008875:Middle Aged; D010870:Pineal Gland / Q000473:pathology / Q000528:radiation effects / Q000601:surgery; D010871:Pinealoma / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery*; D049268:Positron-Emission Tomography; D016634:Radiosurgery / Q000379:methods*; D016019:Survival Analysis; D014057:Tomography, X-Ray Computed
chemical_list: D002250:Carbon Radioisotopes; D007457:Iodine Radioisotopes; D008715:Methionine