title: How complete are current yeast and human protein-interaction networks?
abstract: We estimate the full yeast protein-protein interaction network to contain 37,800-75,500 interactions and the human network 154,000-369,000, but owing to a high false-positive rate, current maps are roughly only 50% and 10% complete, respectively. Paradoxically, releasing raw, unfiltered assay data might help separate true from false interactions.
authors.affiliation: Center for Systems and Synthetic Biology, Institute for Cellular and Molecular Biology, University of Texas at Austin, 2500 Speedway, Austin, TX 78712, USA.
authors.forename: G Traver
authors.initials: GT
authors.lastname: Hart
authors.forename: Arun K
authors.initials: AK
authors.lastname: Ramani
authors.forename: Edward M
authors.initials: EM
authors.lastname: Marcotte
mesh_terms: D030562:Databases, Protein; D006801:Humans; D011485:Protein Binding; D025941:Protein Interaction Mapping; D012441:Saccharomyces cerevisiae / Q000378:metabolism*; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism*
chemical_list: D029701:Saccharomyces cerevisiae Proteins