Investigation of colon-specific dosage forms of ondansetron prepared with natural polymers.
The aim of this study was to develop colon-specific delivery systems of ondansetron using natural polymers such as guar gum and sodium alginate. For this purpose colon specific matrix tablets were prepared by a direct compression method. The physical properties of the tablets were tested and in vitro release studies were performed by a flow-through cell apparatus. The amount of polymers affected the in vitro drug release from the matrix tablets. A high amount of polymers provided slow drug release whereas the release of ondansetron from the tablets prepared with low amount of polymers was found to be fast. Ondansetron-alginate and/or guar gum matrix tablet formulations can deliver the drug to the small and large intestine thus these matrix may be a promising system for the reduction of visceral sensitivity and inhibition of motor activity in irritable bowel syndrome (IBS).
Tuğcu-Demiröz
F
F
Gazi University, Faculty of Pharmacy, Ankara, Turkey.
Acartürk
F
F
Takka
S
S
D000464:Alginates / Q000737:chemistry*; D055598:Chemical Phenomena; D002626:Chemistry, Pharmaceutical; D002627:Chemistry, Physical; D003106:Colon / Q000378:metabolism*; D016503:Drug Delivery Systems; D005079:Excipients; D005685:Galactans / Q000737:chemistry*; D008351:Mannans / Q000737:chemistry*; D017294:Ondansetron / Q000008:administration & dosage* / Q000737:chemistry; D053149:Plant Gums / Q000737:chemistry*; D011108:Polymers; D012702:Serotonin Antagonists / Q000008:administration & dosage* / Q000737:chemistry
D000464:Alginates; D005079:Excipients; D005685:Galactans; D008351:Mannans; D053149:Plant Gums; D011108:Polymers; D012702:Serotonin Antagonists; D017294:Ondansetron; C007894:guar gum