A new stilbene glucoside from the roots of Polygonum multiflorum Thunb.
One new stilbene glucoside (6), along with five known compounds (1-5), were isolated from the roots of Polygonum multiflorum Thumb., and their chemical structures established based on physicochemical and spectroscopic data. Of the compounds, compound 3 showed DNA topoisomerase I and II inhibitory activities.
Xu
Ming-Lu
ML
College of Pharmacy, Yeungnam University, Gyongsan, 712-749, Korea.
Zheng
Ming Shan
MS
Lee
Yeon-Kyong
YK
Moon
Dong-Cheol
DC
Lee
Chong-Soon
CS
Woo
Mi-Hee
MH
Jeong
Byeong-Seon
BS
Lee
Eung Seok
ES
Jahng
Yurngdong
Y
Chang
Hyeun-Wook
HW
Lee
Seung-Ho
SH
Son
Jong-Keun
JK
D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology; D045744:Cell Line, Tumor; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002855:Chromatography, Thin Layer; D004354:Drug Screening Assays, Antitumor; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D018517:Plant Roots / Q000737:chemistry; D028502:Polygonum / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet; D013267:Stilbenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D013778:Tetrazolium Salts; D013844:Thiazoles; D059004:Topoisomerase I Inhibitors; D059005:Topoisomerase II Inhibitors
D000972:Antineoplastic Agents, Phytogenic; D004791:Enzyme Inhibitors; D005960:Glucosides; D013267:Stilbenes; D013778:Tetrazolium Salts; D013844:Thiazoles; D059004:Topoisomerase I Inhibitors; D059005:Topoisomerase II Inhibitors; C022616:thiazolyl blue