Carbohydrate-based scaffolds in drug discovery.
Carbohydrates have been proven as valuable scaffolds to display pharmocophores and the resulting molecules have demonstrated useful biological activity towards various targets including the somatostatin receptors (SSTR), integrins, HIV-1 protease, matrix metalloproteinases (MMP), multidrug resistance-associated protein (MRP), and as RNA binders. Carbohydrate-based compounds have also shown antibacterial and herbicidal activity.
Becker
Bernd
B
Alchemia Ltd, PO Box 6242, Upper Mt Gravatt, Qld 4122, Australia. bbecker@alchemia.com.au
Condie
Glenn C
GC
Le
Giang Thanh
GT
Meutermans
Wim
W
D002241:Carbohydrates / Q000737:chemistry*; D015195:Drug Design
D002241:Carbohydrates