title: Pilomatrix carcinoma with lymph node and pulmonary metastases.
abstract: METHODS
  A 72-year-old male patient developed a locally recurrent pilomatrix carcinoma (PC) of the right upper shank. Within a 2-year period he also developed bilateral pulmonary as well as inguinal, cervical and paraaortic lymph node metastases. After external-beam radiation therapy (EBRT) alone, sole interstitial high-dose-rate (HDR) brachytherapy (BRT) or postoperative EBRT with interstitial HDR-BRT boost, the patient demonstrated regressive or stable disease at the lymphatic sites. Systemic chemotherapy with intravenous paclitaxel failed to assure a substantial pulmonary response. In the course of the disease after 28 months pulmonary progression has led to continuing clinical deterioration.
  
  
  CONCLUSIONS
  In accordance with literature data the hitherto course of this case corroborates that radiation therapy (RT) modalities can play an important role in the treatment of PC.
authors.affiliation: Strahlenklinik, Klinikum Offenbach, Starkenburgring 66, 63069, Offenbach, Germany. ntselis@hotmail.com
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Tselis
authors.forename: Reinhard
authors.initials: R
authors.lastname: Heyd
authors.forename: Hans-Georg
authors.initials: HG
authors.lastname: Vogt
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Zamboglou
mesh_terms: D000368:Aged; D001918:Brachytherapy; D003131:Combined Modality Therapy; D018450:Disease Progression; D019583:Dose Fractionation, Radiation; D005500:Follow-Up Studies; D006201:Hair Diseases / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology / Q000532:radiotherapy / Q000556:secondary*; D008197:Lymph Node Excision; D008207:Lymphatic Metastasis / Q000473:pathology / Q000532:radiotherapy*; D008279:Magnetic Resonance Imaging; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D018296:Pilomatrixoma / Q000473:pathology / Q000532:radiotherapy / Q000556:secondary* / Q000601:surgery; D011867:Radioisotope Teletherapy; D011880:Radiotherapy Planning, Computer-Assisted; D018714:Radiotherapy, Adjuvant; D019233:Retreatment; D012878:Skin Neoplasms / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D014057:Tomography, X-Ray Computed