Effects of glucose-insulin-potassium solution on cardiac cytokines and enzymes.
OBJECTIVE
The aim of this study was to assess the effects of glucose-insulin-potassium (GIK) solution on intraoperative cardiac cytokines and cardiac enzymes in coronary artery bypass surgery patients.


METHODS
The study group consisted of 49 patients with unstable angina who required urgent CABG. Patients were randomized to a GIK (n = 25) or a non-GIK (n = 24) group. The GIK group received 500 ml of 30 % dextrose solution, containing 100 IU insulin and 80 mEq of potassium, at a rate of 1 ml x kg (-1) x h (-1). The control group received an equivalent rate of 5 % dextrose. Serum cytokine levels were measured in blood samples obtained from coronary sinus blood samples. Cardiac enzymes such as creatinin kinase (CK), myocardial band of creatinin kinase (CK-MB) and Troponin-T were measured immediately after operation and at 6, 24 and 48 hours after operation.


RESULTS
No patient in the two groups developed ECG or enzyme changes after surgery suggestive of acute myocardial infarction and myocyte damage. Interleukin-10 concentrations were greater in the GIK group (31.10 +/- 3.36) than in the non-GIK group (19.10 +/- 4.32) ( P < 0.05).


CONCLUSIONS
We conclude that a GIK solution increases the serum cardioprotective interleukin-10 concentrations in CABG patients with unstable angina pectoris. We found no significant difference in any of the other parameters respecting myocyte damage.
Celkan
M A
MA
Department of Cardiovascular Surgery, School of Medicine, Gaziantep University, Gaziantep, Turkey. celkan@superonline.com
Kazaz
H
H
Daglar
B
B
Celik
A
A
Koruk
S
S
Kocoglu
H
H
D000789:Angina, Unstable / Q000097:blood* / Q000201:enzymology / Q000601:surgery; D002314:Cardioplegic Solutions / Q000494:pharmacology*; D001026:Coronary Artery Bypass; D052279:Creatine Kinase, MB Form / Q000097:blood*; D016207:Cytokines / Q000097:blood*; D005260:Female; D005947:Glucose / Q000494:pharmacology; D006321:Heart / Q000187:drug effects; D006801:Humans; D007328:Insulin / Q000494:pharmacology; D016753:Interleukin-10 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D016209:Interleukin-8 / Q000097:blood; D007432:Intraoperative Period; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000201:enzymology / Q000378:metabolism*; D011188:Potassium / Q000494:pharmacology
D002314:Cardioplegic Solutions; D016207:Cytokines; D007328:Insulin; D015850:Interleukin-6; D016209:Interleukin-8; C030396:glucose-insulin-potassium cardioplegic solution; D016753:Interleukin-10; D052279:Creatine Kinase, MB Form; D005947:Glucose; D011188:Potassium