title: Reduction and solution of the chemical master equation using time scale separation and finite state projection.
abstract: The dynamics of chemical reaction networks often takes place on widely differing time scales--from the order of nanoseconds to the order of several days. This is particularly true for gene regulatory networks, which are modeled by chemical kinetics. Multiple time scales in mathematical models often lead to serious computational difficulties, such as numerical stiffness in the case of differential equations or excessively redundant Monte Carlo simulations in the case of stochastic processes. We present a model reduction method for study of stochastic chemical kinetic systems that takes advantage of multiple time scales. The method applies to finite projections of the chemical master equation and allows for effective time scale separation of the system dynamics. We implement this method in a novel numerical algorithm that exploits the time scale separation to achieve model order reductions while enabling error checking and control. We illustrate the efficiency of our method in several examples motivated by recent developments in gene regulatory networks.
authors.affiliation: Department of Mechanical Engineering, University of California-Santa Barbara, Santa Barbara, CA 93106-5070, USA.
authors.forename: Slaven
authors.initials: S
authors.lastname: Peles
authors.forename: Brian
authors.initials: B
authors.lastname: Munsky
authors.forename: Mustafa
authors.initials: M
authors.lastname: Khammash
mesh_terms: D001704:Biopolymers / Q000378:metabolism*; D002468:Cell Physiological Phenomena; D003198:Computer Simulation; D005786:Gene Expression Regulation / Q000502:physiology*; D008954:Models, Biological; D008956:Models, Chemical; D009010:Monte Carlo Method; D015398:Signal Transduction / Q000502:physiology*; D013269:Stochastic Processes
chemical_list: D001704:Biopolymers