Atorvastatin therapy associated with improvement in left ventricular remodeling in a case of idiopathic dilated cardiomyopathy.
Statins have pleiotropic effects such as anti-inflammatory and vascular protective effects that would be beneficial for patients with chronic heart failure. This report describes a patient with idiopathic dilated cardiomyopathy and a long-standing history of heart failure that was treated with atorvastatin in addition to conventional therapy that included beta-blockers. Atorvastatin therapy for 12 months was associated with an improvement in cardiac function and improved left ventricular remodeling and peak oxygen consumption. This result suggests that statin therapy may be a potential novel treatment strategy for patients with chronic heart failure.
Yamada
Takahisa
T
Division of Cardiology, Osaka General Medical Center, Japan. takaymda@nike.eonet.ne.jp
Node
Koichi
K
Mine
Takanao
T
Morita
Takashi
T
Kioka
Hidetaka
H
Tamaki
Shunsuke
S
Tsukamoto
Yasumasa
Y
Masuda
Masaharu
M
Okuda
Keiji
K
Fukunami
Masatake
M
D000328:Adult; D000924:Anticholesteremic Agents / Q000627:therapeutic use; D000069059:Atorvastatin; D002311:Cardiomyopathy, Dilated / Q000188:drug therapy*; D002317:Cardiovascular Agents / Q000627:therapeutic use*; D006538:Heptanoic Acids / Q000494:pharmacology* / Q000627:therapeutic use*; D006801:Humans; D006937:Hypercholesterolemia / Q000188:drug therapy; D008297:Male; D011758:Pyrroles / Q000494:pharmacology* / Q000627:therapeutic use*; D020257:Ventricular Remodeling / Q000187:drug effects*
D000924:Anticholesteremic Agents; D002317:Cardiovascular Agents; D006538:Heptanoic Acids; D011758:Pyrroles; D000069059:Atorvastatin