HLA-G, -E and -F: allelism, function and evolution.
The major histocompatibility complex class I genes comprise a bunch of classical genes (A, B, C), non-classical genes (E, F and G), pseudogenes and truncated genes. MHC-E, -F and -G are now considered immune "tolerization" molecules, which not only interact with NK cells but with T lymphocyte subsets and other cells and have a role in fetus acceptation. A strong positive directional selection is acting for maintaining the observed low polymorphism on E, F and G loci in human and apes. Invariance must be important for this non-classical class I proteins function.
Moscoso
J
J
Department of Immunology, Universidad Complutense, The Madrid Regional Blood Center, Madrid, Spain.
Serrano-Vela
J I
JI
Pacheco
R
R
Arnaiz-Villena
A
A
D000483:Alleles; D000818:Animals; D001483:Base Sequence; D017931:DNA Primers / Q000235:genetics; D019143:Evolution, Molecular; D005260:Female; D005333:Fetus / Q000276:immunology; D014644:Genetic Variation; D006680:HLA Antigens / Q000737:chemistry / Q000235:genetics* / Q000276:immunology*; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I / Q000737:chemistry / Q000235:genetics* / Q000276:immunology*; D006801:Humans; D007108:Immune Tolerance; D008958:Models, Molecular; D011247:Pregnancy; D011323:Primates / Q000235:genetics / Q000276:immunology; D000097625:HLA-E Antigens
D017931:DNA Primers; D006680:HLA Antigens; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I; D000097625:HLA-E Antigens; C062341:HLA-F antigens