Primary cutaneous marginal zone B-cell lymphoma of MALT type in a child.
Marginal zone B-cell lymphoma (MZBCL) of mucosa-associated lymphoid tissue type is a peculiar variant of B-cell neoplasm showing distinct clinical and pathologic features. Its occurrence in children or adolescents is extremely uncommon. We describe the case of an 11-year-old boy who developed such a lymphomatous process involving primarily the skin. The tumor was characterized by a maturing plasma cell population that included immunoblasts, heavy-chain but not light-chain restriction suggestive of monoclonality, and a prevalent, focally granulomatous component of histiocytes. As an additional interesting feature, a trisomy 3 was demonstrated by fluorescence in situ hybridization analysis. The clinical, morphological, phenotypic, and genetic characteristics seen in our patient do not differ significantly from those described in primary cutaneous MZBCL occurring in adults.
Dargent
Jean-Louis
JL
Department of Anatomic Pathology, Centre Hospitalier Universitaire Saint-Pierre/Institut Jules Bordet, Institut Jules Bordet, 1 rue Héger-Bordet, 1000 Brussels, Belgium. jl.dargent@skynet.be
Devalck
Christine
C
De Mey
Albert
A
Vandeweyer
Eric
E
Lespagnard
Laurence
L
Heimann
Pierre
P
D014408:Biomarkers, Tumor / Q000032:analysis; D002648:Child; D002893:Chromosomes, Human, Pair 3; D018572:Disease-Free Survival; D006644:Histiocytes / Q000737:chemistry / Q000473:pathology; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D018442:Lymphoma, B-Cell, Marginal Zone / Q000235:genetics / Q000473:pathology* / Q000601:surgery; D008297:Male; D010950:Plasma Cells / Q000737:chemistry / Q000473:pathology; D012878:Skin Neoplasms / Q000235:genetics / Q000473:pathology* / Q000601:surgery; D014314:Trisomy
D014408:Biomarkers, Tumor