Synthesis and properties of DNA analogs consisting of the benzene-phosphate backbone.
This paper describes DNA analog synthesis consisting of the benzene-phosphate backbone, of which the monomer units are built from benzene-core units connected via a biaryl-like axis to the nucleobases. It was found that the duplex comprised of the analogs had a non-helical structure and was thermally more stable than the corresponding natural DNA duplex.
Ueno
Yoshihito
Y
Department of Biomolecular Science, Faculty of Engineering, Gifu University, Yanagido, Gifu 501-1193, Japan.
Kato
Takumi
T
Sato
Kumiko
K
Ito
Yasutomo
Y
Ebihara
Masahiro
M
Jiye
Jin
J
Kitade
Yukio
Y
D001554:Benzene / Q000737:chemistry*; D002942:Circular Dichroism; D018360:Crystallography, X-Ray; D004247:DNA / Q000138:chemical synthesis* / Q000737:chemistry* / Q000528:radiation effects; D009690:Nucleic Acid Conformation / Q000528:radiation effects; D009692:Nucleic Acid Heteroduplexes / Q000528:radiation effects; D009943:Organophosphorus Compounds / Q000138:chemical synthesis / Q000737:chemistry; D010710:Phosphates / Q000737:chemistry*; D044366:Transition Temperature; D014466:Ultraviolet Rays
D009692:Nucleic Acid Heteroduplexes; D009943:Organophosphorus Compounds; D010710:Phosphates; C434331:phosphoramidite; D004247:DNA; D001554:Benzene