DNA nanowire sensitive to the surrounding condition.
We designed and synthesized an artificial DNA that undergoes a structural transition induced by metal ions. A 2, 2'-bipyridine unit was incorporated into the main chain of d(G4T4G4) instead of thymine. Structural analyses of the artificial DNA with and without metal ions demonstrated that micromolar concentrations of metal ions can induce a structural transition of antiparallel G-quadruplex to a G-wire, which shows the DNA is promising as a controllable and switchable supramolecular device.
Miyoshi
Daisuke
D
Frontier Institute for Biomolecular Engineering Research, Konan University, 8-9-1 Okamoto, Higashinada-ku, Kobe 658-8501, Japan.
Wang
Zhong-Ming
ZM
Karimata
Hisae
H
Sugimoto
Naoki
N
D015082:2,2'-Dipyridyl / Q000737:chemistry*; D002614:Chelating Agents / Q000737:chemistry*; D004247:DNA / Q000138:chemical synthesis / Q000737:chemistry*; D054856:G-Quadruplexes; D006147:Guanine / Q000737:chemistry; D008670:Metals / Q000737:chemistry; D053770:Nanowires / Q000737:chemistry*
D002614:Chelating Agents; D008670:Metals; D015082:2,2'-Dipyridyl; D006147:Guanine; D004247:DNA