[Nefopam by continuous intravenous injection and adverse drug reactions: which causality assessment?].
We report the case of a 77-year-old man, with nefopam postoperative analgesia, who developed subacute neurological symptoms, whereas he had profound hypoprotidemia and acute renal failure. Chronological, semiological and bibliographical criteria are in favour of causality assessment. The plasma nefopam concentration (135 ng/ml) during the neurological symptoms is another argument.
Ould-Ahmed
M
M
Département d'anesthésie-réanimation-urgences, HIA Desgenettes, 108, boulevard Pinel, BP 25, 69998 Lyon, France. mehdi.oa@wanadoo.fr <mehdi.oa@wanadoo.fr>
Drouillard
I
I
El-Kartouti
A
A
Wey
P-F
PF
Lions
C
C
Martinez
J-Y
JY
D058186:Acute Kidney Injury / Q000139:chemically induced; D000368:Aged; D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage* / Q000009:adverse effects*; D006801:Humans; D007019:Hypoproteinemia / Q000139:chemically induced; D007275:Injections, Intravenous; D008297:Male; D009340:Nefopam / Q000008:administration & dosage* / Q000009:adverse effects*; D010149:Postoperative Pain / Q000188:drug therapy
D018712:Analgesics, Non-Narcotic; D009340:Nefopam