title: The in vitro bioactivity of two novel hydrophilic, partially degradable bone cements.
abstract: Composite bone cements were prepared with bioactive glasses (MgO-SiO(2)-3CaO.P(2)O(5)) of different reactivities. The matrix of these so-called hydrophilic, partially degradable and bioactive cements was composed of a starch/cellulose acetate blend and poly(2-hydroxyethyl methacrylate). The addition of 30 wt.% of glasses to this system made them bioactive in acellular medium: a dense apatite layer formed on the surface after 7 days of immersion in simulated body fluid. This was demonstrated both by microscopic and infrared spectroscopic techniques. The composition of the glass and, consequently, its structure was found to have important effects on the rate of the apatite formation. The combination of reactivity obtained by one formulation with the hydrophilic and degradable character of these cements makes them a very promising alternative to conventional acrylic bone cements, by allowing a better stabilization of the implant and a stronger adhesion to the bone.
authors.affiliation: 3B's Research Group - Biomaterials, Biodegradables and Biomimetics, University of Minho, Campus of Gualtar, 4710-057 Braga, Portugal. lfboesel@dep.uminho.pt
authors.forename: Luciano F
authors.initials: LF
authors.lastname: Boesel
authors.forename: Sandra C P
authors.initials: SC
authors.lastname: Cachinho
authors.forename: Maria H V
authors.initials: MH
authors.lastname: Fernandes
authors.forename: Rui L
authors.initials: RL
authors.lastname: Reis
mesh_terms: D001031:Apatites / Q000737:chemistry; D001672:Biocompatible Materials / Q000737:chemistry; D001843:Bone Cements / Q000737:chemistry*; D001842:Bone and Bones / Q000378:metabolism; D005898:Glass / Q000737:chemistry*; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D011108:Polymers / Q000737:chemistry; D019904:Polymethyl Methacrylate / Q000737:chemistry*; D013055:Spectrophotometry, Infrared; D017550:Spectroscopy, Fourier Transform Infrared; D013499:Surface Properties; D013997:Time Factors
chemical_list: D001031:Apatites; D001672:Biocompatible Materials; D001843:Bone Cements; D011108:Polymers; D019904:Polymethyl Methacrylate