Carbohydrate antigens: synthesis aspects and immunological applications in cancer.
Tumor Associated Carbohydrate Antigens (TACAs) constitute powerful tools as tumor markers and as targets for anticancer immunotherapy. In this review, methods of production of glycopeptide-based vaccines, as well as results of preclinical and clinical studies in cancer patients are discussed.
Freire
Teresa
T
CNRS, URA2128, Unité de Chimie Organique, Paris, France. tfreire@pasteur.fr
Bay
Sylvie
S
Vichier-Guerre
Sophie
S
Lo-Man
Richard
R
Leclerc
Claude
C
D000951:Antigens, Neoplasm / Q000096:biosynthesis* / Q000276:immunology; D014408:Biomarkers, Tumor / Q000096:biosynthesis* / Q000276:immunology; D006031:Glycosylation; D006801:Humans; D009369:Neoplasms / Q000175:diagnosis / Q000276:immunology*
D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor