[The inhibitor of free radical processes decrease of protein biosynthesis in gun short wound tissues and weaken development of the general adaptation syndrome].
The dynamics of total protein biosynthesis and procollagen biosynthesis in skeletal muscle of injury tissues with the antioxidant BHT (dibunol) treatment and with common healing were studied. The obtained date indicate that the AO treatment reduce the rate of biosynthesis both the total proteins and procollagen at the 3th day of healing. Dibunol also considerably reduce the protein biosynthesis in adrenals and brake of corticosteroids biogenesis as measured by ESR-signals intensity of reduced adrenodoxine. AO treatment also reduce the protein biosynthesis in thymus, spleen and bone marrow. The lowering of functional activity of endocrine and immune systems indicate that the AO significantly inhibit the systemic reactions of organism induced by acute wound affect. It was suggested that as "primary mediator" of stress-reaction may be considered lipoperoxide radicals and decay products of lipohydroperoide.
Todorov
I N
IN
Bogdanov
G N
GN
Mitrokhin
Iu I
IuI
Varfolomeev
V N
VN
Sidorenko
L I
LI
Mishchenko
D V
DV
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002084:Butylated Hydroxytoluene / Q000494:pharmacology*; D004703:Endocrine System / Q000187:drug effects / Q000378:metabolism; D005609:Free Radicals / Q000378:metabolism; D005790:General Adaptation Syndrome / Q000188:drug therapy / Q000378:metabolism*; D007107:Immune System / Q000187:drug effects / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D009928:Organ Specificity / Q000187:drug effects; D014176:Protein Biosynthesis / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D014945:Wound Healing / Q000187:drug effects; D014948:Wounds, Gunshot / Q000188:drug therapy / Q000378:metabolism*
D000975:Antioxidants; D005609:Free Radicals; D002084:Butylated Hydroxytoluene