title: Clinicopathologic assessment of prenatally diagnosed lung diseases.
abstract: OBJECTIVE
  To investigate the clinical features and pathologic diagnosis of prenatally diagnosed lung diseases.
  
  
  METHODS
  The medical records of 28 fetuses with prenatally diagnosed lung diseases were reviewed with regard to perinatal courses, ultrasonographic measurement of the lesion volume ratio, and the histopathology of lung tissue.
  
  
  RESULTS
  Of the 23 fetuses with a prenatal diagnosis of congenital cystic adenomatoid malformation (CCAM), 4 required an emergency lobectomy (1 prenatally and 3 postnatally), whereas the other 14 showed uneventful courses after birth. The pathologic diagnosis of the resected lungs included CCAM (n = 4), lobar emphysema (n = 2), intralobar sequestration (n = 2), and bronchial atresia (n = 1). The peak value of the lesion volume ratio was significantly higher in the CCAM cases that required urgent surgery than in the non-CCAM cases (2.29 +/- 0.46 vs 1.20 +/- 0.21, P < .001). The ratio decreased after the 25th to the 30th week to less than 1.0 in the 5 non-CCAM cases, but remained higher than 2.0 in the 4 CCAM cases. Prenatally diagnosed extralobar pulmonary sequestration caused massive pleural effusion requiring a fetal intervention in 4 of the 5 fetuses.
  
  
  CONCLUSIONS
  The prenatally diagnosed lung lesions include various kinds of pulmonary diseases. Regardless of the diseases, sequential ultrasonographic assessment may predict perinatal risks.
authors.affiliation: Department of Surgery, National Center for Child Health and Development, Tokyo 157-8535, Japan. kuroda-t@ncchd.go.jp
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Kuroda
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Morikawa
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Kitano
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Sago
authors.forename: Satoshi
authors.initials: S
authors.lastname: Hayashi
authors.forename: Toshiro
authors.initials: T
authors.lastname: Honna
authors.forename: Morihiro
authors.initials: M
authors.lastname: Saeki
mesh_terms: D015615:Cystic Adenomatoid Malformation of Lung, Congenital / Q000000981:diagnostic imaging* / Q000473:pathology*; D005260:Female; D006801:Humans; D011013:Pneumonectomy; D011247:Pregnancy; D011296:Prenatal Diagnosis; D012189:Retrospective Studies; D014463:Ultrasonography