[Expression of vascular permeability factor in human vocal cord polyps].
OBJECTIVE
This study aimed to analyse the expression of vascular permeability factor (VPF) in human vocal fold polyps. Meanwhile, we studied the pathogenesis of vocal cord polyp further.


METHODS
The expression of VPF were detected with immunohistochemical staining in the 37 cases with vocal cord polyps and 11 healthy vocal folds tissues (SP method). Meanwhile,the positive results were contrasted.


RESULTS
The percent of positive expression of VPF was 51.35 in vocal cord polyps. This expression tended not to be increased greatly compared with the percent of positive expression of VPF (18.18%) in healthy vocal fold (P > 0.05). But,the percent of positive vascular counts of VPF in the vocal cord polyps (56.66 +/- 25.48) %was higher than that in the healthy vocal fold tissues (37.11 +/- 29.52)% (P < 0.05). In the vocal cord polyps , there was no significant difference in the expression of VPF between the male and female( P > 0.05).


CONCLUSIONS
The VPF may play a key role in the formation of heavy edema of vocal cord polyps. The VPF may be involved in the formation and development of vocal cord polyps . If we can control the produce of VPF in the vocal cord polyps, we may find a new way to treat it.
Wu
Ping
P
Department of Otolaryngology, the Second Affiliated Hospital of Kunming Medical College, Kunming,650101, China.
Liu
Tao
T
Zheng
Mingxiu
M
Chen
Jing
J
D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007818:Laryngeal Diseases / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011127:Polyps / Q000378:metabolism*; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism*; D014827:Vocal Cords
C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A