Morphochemical study of hippocampus of august rats after systemic treatment with amphetamine followed by injection of delta sleep-inducing peptide.
Quantitative interferometry showed that chronic amphetamine administration to August rats (2.5 mg/kg/day for 3 weeks) increased the area of neuronal cytoplasm and nuclei and content and concentrations of proteins in hippocampal CA3 neurons. These changes persisted after single injection of delta sleep-inducing peptide (60 microg/kg). The reaction of the entire neuronal population of hippocampal CA3 neurons to amphetamine is similar.
Gershtein
L M
LM
Laboratory of Brain Ultrastructure and Cytochemistry, Institute of Brain, Russian Academy of Medical Sciences, Moscow. es-gershtein@mtu-net.ru
Sergutina
A V
AV
Rakhmanova
V I
VI
D000662:Amphetamines / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism; D003593:Cytoplasm / Q000378:metabolism; D003701:Delta Sleep-Inducing Peptide / Q000627:therapeutic use*; D006624:Hippocampus / Q000187:drug effects* / Q000378:metabolism; D009474:Neurons / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D017208:Rats, Wistar
D000662:Amphetamines; D003701:Delta Sleep-Inducing Peptide