title: Atorvastatin therapy associated with improvement in left ventricular remodeling in a case of idiopathic dilated cardiomyopathy.
abstract: Statins have pleiotropic effects such as anti-inflammatory and vascular protective effects that would be beneficial for patients with chronic heart failure. This report describes a patient with idiopathic dilated cardiomyopathy and a long-standing history of heart failure that was treated with atorvastatin in addition to conventional therapy that included beta-blockers. Atorvastatin therapy for 12 months was associated with an improvement in cardiac function and improved left ventricular remodeling and peak oxygen consumption. This result suggests that statin therapy may be a potential novel treatment strategy for patients with chronic heart failure.
authors.affiliation: Division of Cardiology, Osaka General Medical Center, Japan. takaymda@nike.eonet.ne.jp
authors.forename: Takahisa
authors.initials: T
authors.lastname: Yamada
authors.forename: Koichi
authors.initials: K
authors.lastname: Node
authors.forename: Takanao
authors.initials: T
authors.lastname: Mine
authors.forename: Takashi
authors.initials: T
authors.lastname: Morita
authors.forename: Hidetaka
authors.initials: H
authors.lastname: Kioka
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Tamaki
authors.forename: Yasumasa
authors.initials: Y
authors.lastname: Tsukamoto
authors.forename: Masaharu
authors.initials: M
authors.lastname: Masuda
authors.forename: Keiji
authors.initials: K
authors.lastname: Okuda
authors.forename: Masatake
authors.initials: M
authors.lastname: Fukunami
mesh_terms: D000328:Adult; D000924:Anticholesteremic Agents / Q000627:therapeutic use; D000069059:Atorvastatin; D002311:Cardiomyopathy, Dilated / Q000188:drug therapy*; D002317:Cardiovascular Agents / Q000627:therapeutic use*; D006538:Heptanoic Acids / Q000494:pharmacology* / Q000627:therapeutic use*; D006801:Humans; D006937:Hypercholesterolemia / Q000188:drug therapy; D008297:Male; D011758:Pyrroles / Q000494:pharmacology* / Q000627:therapeutic use*; D020257:Ventricular Remodeling / Q000187:drug effects*
chemical_list: D000924:Anticholesteremic Agents; D002317:Cardiovascular Agents; D006538:Heptanoic Acids; D011758:Pyrroles; D000069059:Atorvastatin