[The tissue-specific effect of synthetic peptides-biologic regulators in organotypic tissues culture in young and old rats].
The synthetic peptides--cardiogen, bronchogen, prostamax and pancragen were used to investigate their effect on organotypic tissue culture of explants from heart, lungs, prostatic gland and pancreas of young (3-week old) and aged (18-month old) rats. The peptide effective concentration of 0.05 ng/ml showed a stimulating effect in appropriate tissue cultures as compared to the control explants in all groups of rats. So these bioregulatory peptides can be used in clinic practice for the stimulation of reparative processes in the appropriate tissues while ageing.
Zakutskiĭ
A N
AN
Chalisova
N I
NI
Ryzhak
G A
GA
Aniskina
A I
AI
Filippov
S V
SV
Zeziulin
P N
PN
D000375:Aging / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D006321:Heart / Q000187:drug effects; D008168:Lung / Q000187:drug effects / Q000378:metabolism; D008297:Male; D009206:Myocardium / Q000378:metabolism; D009928:Organ Specificity; D010179:Pancreas / Q000187:drug effects / Q000378:metabolism; D010455:Peptides / Q000378:metabolism / Q000494:pharmacology*; D011467:Prostate / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D046509:Tissue Culture Techniques
D010455:Peptides