Cyclopentanone ring-cleaved pleuromutilin derivatives.
Ring-cleaved pleuromutilin derivatives comprised of a [5.3.1] bicyclic core structure have been synthesized and evaluated in vitro as antibacterial agents. Four of the compounds described were found to have MICs<or=4 microg/mL against marker strains of Streptococcus pneumoniae and Staphylococcus aureus.
Springer
Dane M
DM
Anti-infective Chemistry, Bristol-Myers Squibb Pharmaceutical Research Institute, 5 Research Parkway, P.O. Box 5100, Wallingford, CT 06492, USA. springd@wyeth.com <springd@wyeth.com>
Bunker
Amy
A
Luh
Bing-Yu
BY
Sorenson
Margaret E
ME
Goodrich
Jason T
JT
Bronson
Joanne J
JJ
DenBleyker
Kenneth
K
Dougherty
Thomas J
TJ
Fung-Tomc
Joan
J
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D004224:Diterpenes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D011083:Polycyclic Compounds; D013211:Staphylococcus aureus / Q000187:drug effects; D013296:Streptococcus pneumoniae / Q000187:drug effects; D013329:Structure-Activity Relationship; D000097567:Pleuromutilins
D000900:Anti-Bacterial Agents; D004224:Diterpenes; D011083:Polycyclic Compounds; D000097567:Pleuromutilins