title: Lung volume reduction surgery.
abstract: Lung volume reduction surgery (LVRS) has been widely studied and has been available for the treatment of advanced emphysema for 10 years. This paper reviews some of the historical attempts at surgical treatment of emphysema, the physiology of LVRS, and the modern data on patient selection, risks, and benefits. Data from the National Emphysema Treatment Trial are presented in the context of the large body of case series and smaller randomized trials that have preceded that study. Future technologies of bronchoscopic lung volume reduction are also discussed.
authors.affiliation: Division of Pulmonary and Critical Care Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA. cbrown21@jhmi.edu
authors.forename: Cynthia D
authors.initials: CD
authors.lastname: Brown
authors.forename: Henry E
authors.initials: HE
authors.lastname: Fessler
mesh_terms: D001999:Bronchoscopy; D017079:Exercise Tolerance; D006801:Humans; D018579:Patient Selection; D011013:Pneumonectomy / Q000379:methods*; D011183:Postoperative Complications; D011656:Pulmonary Emphysema / Q000503:physiopathology / Q000601:surgery*; D011788:Quality of Life; D012129:Respiratory Function Tests; D020775:Thoracic Surgery, Video-Assisted; D013908:Thoracotomy