Hox genes: realising the importance of realisators.
A recent study for the first time unravels a complete Hox regulatory network sufficient for the specification of a simple organ in Drosophila, linking Hox output to one specific group of executive genes, the realisators. As these genes have a direct effect on cellular functions and are required in most cell types, Hox genes may ultimately execute their function in controlling segmental fate by fine-tuning the spatial and temporal expression levels of these realisators.
Lohmann
Ingrid
I
Max-Planck-Institute for Developmental Biology, Department for Molecular Biology, Spemannstrasse 37-39, 72076 Tübingen, Germany. ilohmann@tuebingen.mpg.de
D000818:Animals; D015820:Cadherins / Q000502:physiology; D002448:Cell Adhesion; D016764:Cell Polarity; D004330:Drosophila / Q000196:embryology / Q000235:genetics*; D029721:Drosophila Proteins / Q000235:genetics*; D005801:Genes, Homeobox / Q000502:physiology*; D018398:Homeodomain Proteins / Q000235:genetics*; D038081:Organogenesis
C062393:Abd-B proteins, Drosophila; D015820:Cadherins; D029721:Drosophila Proteins; D018398:Homeodomain Proteins