title: Revenge of the NRD: preferential degradation of nonfunctional eukaryotic rRNA.
abstract: Eukaryotic cells have several quality control systems that monitor the proper processing of RNAs during RNA biogenesis or the function of cytoplasmic mRNAs. A recent study in Molecular Cell by LaRiviere et al. (2006) shows that after production, mature rRNA is also subject to quality control and nonfunctional ribosomes are targeted for destruction by a novel ribosome surveillance mechanism.
authors.affiliation: Howard Hughes Medical Institute, Department of Molecular and Cellular Biology, University of Arizona, Tucson, Arizona 85721, USA.
authors.forename: Meenakshi K
authors.initials: MK
authors.lastname: Doma
authors.forename: Roy
authors.initials: R
authors.lastname: Parker
mesh_terms: D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism; D005057:Eukaryotic Cells; D006801:Humans; D012322:RNA Precursors / Q000378:metabolism*; D012323:RNA Processing, Post-Transcriptional; D012335:RNA, Ribosomal / Q000378:metabolism*
chemical_list: D012322:RNA Precursors; D012335:RNA, Ribosomal