title: Myoelectric activity and motility of the Roux limb after cut or uncut Roux-en-Y gastrojejunostomy.
abstract: OBJECTIVE
  To explore the mechanisms of uncut Roux-en-Y gastrojejunostomy, which is used to decrease the occurrence of Roux stasis syndrome.
  
  
  METHODS
  The changes of myoelectric activity, mechanic motility and interstitial cells of Cajal (ICC) of the Roux limb after cut or uncut Roux-en-Y gastrojejunostomy were observed.
  
  
  RESULTS
  When compared with the cut group, the amplitude (1.15 +/- 0.15 mV vs 0.48 +/- 0.06 mV, P < 0.05) and frequency (14.4 +/- 1.9 cpm vs 9.5 +/- 1.1 cpm, P < 0.01) of slow waves and the incidence (98.2% +/- 10.4% vs 56.6% +/- 6.4%, P < 0.05) and amplitude (0.58 +/- 0.08 mV vs 0.23 +/- 0.06 mV, P < 0.01) of spike potential of the Roux limb in the uncut group were significantly higher. The migrating myoelectric complexes (MMC) phase III duration in the uncut group was significantly prolonged (6.5 +/- 1.1 min vs 4.4 +/- 0.8 min, P < 0.05), while the MMC cycle obviously shortened (42.5 +/- 6.8 vs 55.3 +/- 8.2 min, P < 0.05). Both gastric emptying rate (65.5% +/- 7.9% vs 49.3% +/- 6.8%, P < 0.01) and intestinal impelling ratio (53.4% +/- 7.4% vs 32.2% +/- 5.4%, P < 0.01) in the uncut group were significantly increased. The contractile force index of the isolated jejunal segment in the uncut group was significantly higher (36.8 +/- 5.1 vs 15.3 +/- 2.2, P < 0.01), and the expression of c-kit mRNA was significantly increased in the uncut group (0.82 +/- 0.11 vs 0.35 +/- 0.06, P < 0.01).
  
  
  CONCLUSIONS
  Uncut Roux-en-Y gastrojejunostomy may lessen the effects of operation on myoelectric activity such as slow waves, spike potential, and MMC, decrease the impairment of gastrointestinal motility, and remarkably increase the expression of c-kit mRNA.
authors.affiliation: Central Laboratory, First Clinical College of Harbin Medical University, Harbin 150001, Heilongjiang Province, China.
authors.forename: Ying-Mei
authors.initials: YM
authors.lastname: Zhang
authors.forename: Xiu-Li
authors.initials: XL
authors.lastname: Liu
authors.forename: Dong-Bo
authors.initials: DB
authors.lastname: Xue
authors.forename: Yun-Wei
authors.initials: YW
authors.lastname: Wei
authors.forename: Xiao-Guang
authors.initials: XG
authors.lastname: Yun
mesh_terms: D000713:Anastomosis, Roux-en-Y / Q000379:methods*; D000818:Animals; D015390:Gastric Bypass / Q000379:methods*; D005769:Gastrointestinal Motility / Q000502:physiology*; D008297:Male; D016065:Myoelectric Complex, Migrating / Q000502:physiology*; D011183:Postoperative Complications / Q000503:physiopathology* / Q000517:prevention & control; D051381:Rats; D017208:Rats, Wistar