title: [Neovascularisation as a cause of recurrence after varicose veins operation].
abstract: OBJECTIVE
  Following surgical therapy, new varicose veins may develop, in particular at the site of the previous saphenofemoral junction. The objective of this study is the appreciation of the causes of the bad results of surgical procedures in the treatment of varicose veins and the proposal of the possibilities of their prevention.
  
  
  METHODS
  Retrospective study of the group of 404 patients (573 procedures) with the diagnosis of the recurrence after previous radical surgery was performed. After exclusion of perforator refluxes, the most frequently, the great saphenous vein territory was affected (86%), followed by the small saphenous vein territory (14%). The group of 30 consecutive patients (35 limbs) with saphenofemoral or saphenopopliteal recurrence was selected for this study. Based on preoperative ultrasound and per-operative morphological findings, in 12 patients (14 limbs) - 8 women and 4 men, meticulous histopathological examination of the venous tissue block from the saphenofemoral or saphenopopliteal region, VEGF (Vascular endothelial growth factor) and protein S-100 investigation were performed.
  
  
  RESULTS
  In 14 limbs with sonographic and clinical suspition for neovascularisation, this entity was confirmed in 11 of them (79%) which represents 31.42% of the whole group.
  
  
  CONCLUSIONS
  The varicose veins recurrences can be observed not only after technically or tactically imperfect primary procedure (which is surely the most common cause of the varicose veins recurrence), but also after the operations performed by the experienced venous surgeon in the perfect way. Neovascularisation explains a certain number of postoperative recurrences despite correctly conducted disconnection of the saphenous termination. The endovascular procedures (endovenous laser or radiofrequency saphenous obliteration) without open groin access can minimise the possibility of this complication.
authors.affiliation: Ustav zdravotnických studií Univerzity Pardubice. kaspar@flebocentrum.cz
authors.forename: S
authors.initials: S
authors.lastname: Kaspar
authors.forename: D
authors.initials: D
authors.lastname: Hadzi Nikolov
authors.forename: T
authors.initials: T
authors.lastname: Danek
authors.forename: R
authors.initials: R
authors.lastname: Maixner
authors.forename: K
authors.initials: K
authors.lastname: Havlícek
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007866:Leg / Q000098:blood supply*; D008297:Male; D008875:Middle Aged; D009389:Neovascularization, Pathologic / Q000150:complications* / Q000503:physiopathology; D012008:Recurrence; D009418:S100 Proteins / Q000032:analysis; D014648:Varicose Veins / Q000503:physiopathology / Q000601:surgery*; D042461:Vascular Endothelial Growth Factor A / Q000032:analysis; D014680:Veins / Q000737:chemistry
chemical_list: D009418:S100 Proteins; D042461:Vascular Endothelial Growth Factor A