From vivarium to bedside: lessons learned from animal models.
In this review, we focus primarily on information obtained by studying mouse models of heritable ocular diseases. These models have proven to be important in advancing our understanding of disease etiology and of pathological consequences of heritable disorders. Careful phenotypic analyses of these models have lead to hypotheses regarding the function of various molecules as well as the mechanisms underlying the observed pathologies. Specific examples of the utility of mouse models in vision research are discussed.
Budzynski
Ewa
E
The Jackson Laboratory, Bar Harbor, ME 04609, USA.
Lee
Yongsuk
Y
Sakamoto
Kenji
K
Naggert
Juergen K
JK
Nishina
Patsy M
PM
D000818:Animals; D004195:Disease Models, Animal; D015785:Eye Diseases, Hereditary / Q000235:genetics*; D006799:Housing, Animal; D006801:Humans; D019095:Point-of-Care Systems; D012164:Retinal Diseases / Q000235:genetics*