title: A family predisposition to adult T-cell leukemia.
abstract: We report here the rare case of a family predisposed to adult T-cell leukemia (ATL). Six of seven siblings developed ATL with ages of onset of 77, 48, 60, 64, 72, and 62 years old. Although virological tests for human T-lymphotropic virus type 1 were unavailable for two of the six patients, all were diagnosed with ATL based on their clinical, hematological, and histopathological features. Two of the six patients were tested for HLA haplotypes using fresh blood samples, and both were carriers of the HLA-A*26 allele known in the southern Japanese population to be susceptible to ATL. This series of genetic traits may help explain the familial predisposition to ATL.
authors.affiliation: Internal Medicine, Kagoshima Prefectural Hokusatsu Hospital, Kagoshima, Japan.
authors.forename: Kouichiro
authors.initials: K
authors.lastname: Nomura
authors.forename: Atae
authors.initials: A
authors.lastname: Utsunomiya
authors.forename: Hironori
authors.initials: H
authors.lastname: Furushou
authors.forename: Mitsutoshi
authors.initials: M
authors.lastname: Tara
authors.forename: Masashi
authors.initials: M
authors.lastname: Hazeki
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Tokunaga
authors.forename: Kimiharu
authors.initials: K
authors.lastname: Uozumi
authors.forename: Shuichi
authors.initials: S
authors.lastname: Hanada
authors.forename: Shinji
authors.initials: S
authors.lastname: Yashiki
authors.forename: Kazuo
authors.initials: K
authors.lastname: Tajima
authors.forename: Shunro
authors.initials: S
authors.lastname: Sonoda
mesh_terms: D000368:Aged; D005260:Female; D020022:Genetic Predisposition to Disease; D015234:HLA-A Antigens / Q000235:genetics*; D015490:HTLV-I Infections / Q000150:complications; D015368:Human T-lymphotropic virus 1; D006801:Humans; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010375:Pedigree
chemical_list: D015234:HLA-A Antigens