title: Evidence that brain MAO A activity does not correspond to MAO A genotype in healthy male subjects.
abstract: BACKGROUND
  A functional polymorphism in the promoter region of the monoamine oxidase A (MAO A) gene has two common alleles that are referred to as the high and low MAO A genotypes. We report the first in vivo human study to determine whether there is an association between MAO A genotype and brain MAO A activity in healthy male subjects.
  
  
  METHODS
  Brain MAO A activity was measured with positron emission tomography and [(11)C]clorgyline in 38 healthy adult male nonsmokers genotyped for MAO A polymorphism.
  
  
  RESULTS
  There was no significant difference in brain MAO A activity between the high (n = 26) and low (n = 12) MAO A genotypes.
  
  
  CONCLUSIONS
  The lack of an association between the high and low MAO A genotype and brain MAO A activity suggests that this polymorphism by itself does not contribute to differences in brain MAO A activity in healthy adult male subjects.
authors.affiliation: Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA. fowler@bnl.gov
authors.forename: Joanna S
authors.initials: JS
authors.lastname: Fowler
authors.forename: Nelly
authors.initials: N
authors.lastname: Alia-Klein
authors.forename: Aarti
authors.initials: A
authors.lastname: Kriplani
authors.forename: Jean
authors.initials: J
authors.lastname: Logan
authors.forename: Benjamin
authors.initials: B
authors.lastname: Williams
authors.forename: Wei
authors.initials: W
authors.lastname: Zhu
authors.forename: Ian W
authors.initials: IW
authors.lastname: Craig
authors.forename: Frank
authors.initials: F
authors.lastname: Telang
authors.forename: Rita
authors.initials: R
authors.lastname: Goldstein
authors.forename: Nora D
authors.initials: ND
authors.lastname: Volkow
authors.forename: Paul
authors.initials: P
authors.lastname: Vaska
authors.forename: Gene-Jack
authors.initials: GJ
authors.lastname: Wang
mesh_terms: D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging / Q000187:drug effects / Q000201:enzymology*; D001931:Brain Mapping; D002250:Carbon Radioisotopes / Q000378:metabolism; D003010:Clorgyline / Q000494:pharmacology; D006801:Humans; D008297:Male; D018598:Minisatellite Repeats / Q000235:genetics; D008995:Monoamine Oxidase / Q000187:drug effects / Q000235:genetics* / Q000378:metabolism*; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals / Q000378:metabolism; D012016:Reference Values
chemical_list: D002250:Carbon Radioisotopes; D008996:Monoamine Oxidase Inhibitors; D019275:Radiopharmaceuticals; D008995:Monoamine Oxidase; D003010:Clorgyline