title: Factors affecting morbidity and mortality in gangrenous cholecystitis.
abstract: BACKGROUND
  Gangrenous cholecystitis is a serious complication of acute cholecystitis. Male gender, older age, leukocytosis, cardio-vascular diseases and diabetes were reported as factors that increase the risk of gangrenous cholecystitis. The aim our study was to determine variables affecting morbidity and mortality as well as to define the independent risk factors in Gangrenous Cholecystitis.
  
  
  METHODS
  Fifty three patients who had been treated for Gangrenous Cholecystitis were reviewed. The variables are defined as follows: age, gender, systemic diseases, Mannheim Peritonitis index, aspartate aminotransferase, alanine aminotransferase, white blood cell count and type of surgery. In order to determine the independent risk factors that might affect morbidity and mortality in Gangrenous Cholecystitis, we made use of multivariate logistic regression analysis.
  
  
  RESULTS
  The independent risk factors affecting on morbidity were age (P = 0.037), existing systemic disease (P = 0.047) and > or = 29 Mannheim Peritonitis index (P = 0.008), and the independent risk factors affecting on mortality were age (P = 0.046), white blood cell count (P = 0.035). Pre-operative and post-operative third day aspartate amino-transferase and alanine aminotransferase average values were compared, there was a significant difference (P < 0.0001, P < 0.0001 respectively).
  
  
  CONCLUSIONS
  We found that older age, > or = 29 Mannheim Peritonitis index and existence of systemic diseases were independent risk factors affecting morbidity. Older age and lower of white blood cell count were independent risk factors affecting mortality. We believe that further comprehensive studies, involving prospective, multi-center and a large number of patients, are needed.
authors.affiliation: Department of General Surgery, School of Medicine, University of Dicle, Diyarbakir/Turkey. sgirgin@dicle.edu.tr
authors.forename: S
authors.initials: S
authors.lastname: Girgin
authors.forename: E
authors.initials: E
authors.lastname: Gedik
authors.forename: I H
authors.initials: IH
authors.lastname: Taçyildiz
authors.forename: Y
authors.initials: Y
authors.lastname: Akgün
authors.forename: B
authors.initials: B
authors.lastname: Baç
authors.forename: E
authors.initials: E
authors.lastname: Uysal
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000410:Alanine Transaminase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D002318:Cardiovascular Diseases / Q000150:complications; D002764:Cholecystitis / Q000209:etiology / Q000401:mortality*; D048909:Diabetes Complications; D005260:Female; D005734:Gangrene / Q000209:etiology / Q000401:mortality; D006801:Humans; D007964:Leukocytosis / Q000150:complications; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012307:Risk Factors; D012737:Sex Factors
chemical_list: D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase