title: S-adenosylmethionine (SAM)-accumulating sake yeast suppresses acute alcohol-induced liver injury in mice.
abstract: The suppressive effects on acute alcoholic liver injury of S-adenosylmethionine (SAM) and the sake yeast, Saccharomyces cerevisiae Kyokai No. 9, have been shown previously. To enhance the suppression of acute alcoholic liver injury by sake yeast, we prepared SAM-accumulating sake yeast (SAM yeast). Male C57BL/6 mice that had been fed on a diet containing 0.25% SAM yeast or sake yeast for two weeks received three doses of ethanol (5 g/kg BW). In the mice fed on the SAM yeast, the ethanol-induced increases in both triglyceride (TG) and alanine aminotransferase (ALT) were significantly repressed. In addition, the SAM yeast-fed mice did not show an ethanol-induced decrease in hepatic SAM level, suggesting that a disorder of methionine metabolism in the liver caused by ethanol was relieved by the SAM yeast. These results suggest that the SAM yeast had a stronger effect suppressing acute alcoholic liver injury in mice than the sake yeast.
authors.affiliation: National Research Institute of Brewing, Hiroshima. izu@nrib.go.jp
authors.forename: Hanae
authors.initials: H
authors.lastname: Izu
authors.forename: Megumi
authors.initials: M
authors.lastname: Shobayashi
authors.forename: Yasuko
authors.initials: Y
authors.lastname: Manabe
authors.forename: Kuniyasu
authors.initials: K
authors.lastname: Goto
authors.forename: Haruyuki
authors.initials: H
authors.lastname: Iefuji
mesh_terms: D000410:Alanine Transaminase / Q000378:metabolism; D000818:Animals; D000431:Ethanol / Q000633:toxicity*; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000293:injuries / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D012436:S-Adenosylmethionine / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000378:metabolism*; D014280:Triglycerides / Q000378:metabolism
chemical_list: D014280:Triglycerides; D000431:Ethanol; D012436:S-Adenosylmethionine; D000410:Alanine Transaminase