Myeloproliferative disease in the pathogenesis and survival of Budd-Chiari syndrome.
We studied the etiology, diagnosis and natural course of myeloproliferative disease (MPD) in 40 consecutive patients with Budd-Chiari syndrome (BCS). In 38% of the BCS patients with MPD another etiological factor was found. JAK2 mutation was present in 41% of the tested BCS patients. Survival was not significantly affected by the presence of MPD.
Smalberg
Jasper H
JH
Darwish Murad
Sarwa
S
Braakman
Eric
E
Valk
Peter J
PJ
Janssen
Harry L A
HL
Leebeek
Frank W G
FW
D000328:Adult; D006502:Budd-Chiari Syndrome / Q000209:etiology* / Q000401:mortality*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009196:Myeloproliferative Disorders / Q000150:complications* / Q000401:mortality*; D016019:Survival Analysis