[The change of transforming growth factor-beta1 in nonproliferation diabetic retinopathy].
OBJECTIVE
To evaluate the relationship between the level of transforming growth factor-beta1 (TGF-beta1) in serum of patients with nonproliferation diabetic retinopathy and the severity of this retinopathy, and to find out a new method for early intervention of diabetic retinopathy.


METHODS
TGF-beta1 in serum was measured in the three groups as following: group DR containing the patients with nonproliferation diabetic retinopathy identified by funds fluorescein angiography, group DM consisting of diabetic without diabetic retinopathy, and group C containing healthy people, and analysed statistically. Then the patients with diabetic retinopathy were divided into three subgroups based on the phase of retinopathy: DR1, DR2, DR3, which results were also analysed statistically.


RESULTS
The level of TGF-beta1 in serum had no significant difference between the group DM and group C, and the level of the group DR was higher than group DM or the group C significantly. The level of the group DR1 was lower than the group DR2 DR3 significantly.


CONCLUSIONS
In patients with nonproliferation diabetic retinopathy, the level of TGF-beta1, in serum is increased, and can reflect the severity of diabetic retinopathy. The level of TGF-beta1 in serum can also indicate the time of intervention to a certain extent.
ye
Jianhua
J
The First Affiliated Hospital, Guangdong Medicine College, Guangzhou 510080, China. dragonye2002@yahoo.com.cn
Lin
Xiaofeng
X
Ma
Chenghong
C
D000368:Aged; D003930:Diabetic Retinopathy / Q000097:blood* / Q000473:pathology; D006801:Humans; D008875:Middle Aged; D053773:Transforming Growth Factor beta1 / Q000097:blood*
D053773:Transforming Growth Factor beta1