title: Pinkus tumor may originate from intraepidermal eccrine ducts and proliferate in the dermis.
abstract: To clarify the histopathogenesis of Pinkus tumor (fibroepithelial basal cell carcinoma, FEBCC), we have studied cytokeratin (CK) expression in FEBCC using ten different anti-keratin antibodies against CK 1, 7, 8, 10, 14, 15, 16, 17, 18 and 19. Tumor nests consisted of two epithelial components: duct-like structures and basaloid cells of anastomosing strands. In duct-like structure, CK 1, 10, 14, 16, 17 and 19 were detected. CK expression of duct-like structure showed the hyperproliferative state of eccrine intraepidermal ducts. In basaloid cells of anastomosing strands, CK 14 and 17 were detectable. These results suggested that duct-like structure originates from the intraepidermal duct and proliferates to spread in the dermis.
authors.affiliation: Department of Dermatology, Mie University Graduate School of Medicine, 2-174 Edobachi, Tsu, Mie 514-8507, Japan. kuroichi@clin.medic.mie-u.ac.jp
authors.forename: Ichiro
authors.initials: I
authors.lastname: Kurokawa
authors.forename: Tomoya
authors.initials: T
authors.lastname: Yokoyama
authors.forename: Keisuke
authors.initials: K
authors.lastname: Nishimura
authors.forename: Arata
authors.initials: A
authors.lastname: Hakamada
authors.forename: Ken-ichi
authors.initials: K
authors.lastname: Isoda
authors.forename: Kei-ichi
authors.initials: K
authors.lastname: Yamanaka
authors.forename: Airo
authors.initials: A
authors.lastname: Tsubura
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Mizutani
mesh_terms: D000369:Aged, 80 and over; D000906:Antibodies / Q000276:immunology; D002280:Basal Cell Carcinoma / Q000378:metabolism / Q000473:pathology*; D004439:Eccrine Glands / Q000378:metabolism / Q000473:pathology*; D004801:Eosine Yellowish-(YS); D004847:Epithelial Cells / Q000378:metabolism / Q000473:pathology; D006416:Hematoxylin; D006801:Humans; D007150:Immunohistochemistry; D007633:Keratins / Q000096:biosynthesis / Q000276:immunology; D008297:Male; D018225:Neoplasms, Fibroepithelial / Q000378:metabolism / Q000473:pathology*; D012878:Skin Neoplasms / Q000378:metabolism / Q000473:pathology*; D013194:Staining and Labeling / Q000379:methods
chemical_list: D000906:Antibodies; D007633:Keratins; D004801:Eosine Yellowish-(YS); D006416:Hematoxylin