title: Novel drug releasing system triggered by hybridization with target sequence.
abstract: We have already established the strategy of synchronous activation by hybridization, in which the highly reactive cross-linking agent, 2-amino-6-vinylpurine nucleoside analog can be generated from its stable precursors, the phenylsulfide derivatives, by a hybridization-promoted activation process with selectivity to cytosine. In this study, this in situ activation system was applied to method for the drug releasing system triggered by hybridization with the target sequence.
authors.affiliation: Institute of Multidisciplinary Research for Advanced Materials Tohoku University, Katahira 2-1-1, Aoba-ku, Sendai-Shi, Miyagi, Japan.
authors.forename: Shizuka
authors.initials: S
authors.lastname: Nakayama
authors.forename: Fumi
authors.initials: F
authors.lastname: Nagatsugi
authors.forename: Shigeki
authors.initials: S
authors.lastname: Sasaki
mesh_terms: D003432:Cross-Linking Reagents / Q000737:chemistry; D003596:Cytosine / Q000737:chemistry; D016503:Drug Delivery Systems / Q000379:methods*; D031541:Fluorescence Resonance Energy Transfer; D009693:Nucleic Acid Hybridization; D015345:Oligonucleotide Probes / Q000737:chemistry; D011687:Purines / Q000737:chemistry; D014753:Vinyl Compounds / Q000737:chemistry
chemical_list: C432203:2-amino-6-vinylpurine; D003432:Cross-Linking Reagents; D015345:Oligonucleotide Probes; D011687:Purines; D014753:Vinyl Compounds; D003596:Cytosine