title: Mikania laevigata syrup does not induce side effects on reproductive system of male Wistar rats.
abstract: Mikania laevigata (Asteraceae) is a native plant from South America and popularly used as antispasmodic and to treat respiratory diseases. Coumarin is the major chemical substance found in this plant, which have been shown to have antifertility activity in female rats. This study evaluates the toxicity of the exposure to the Mikania laevigata syrup using coumarin as chemical marker on reproductive endpoints in male Wistar rats. Endpoints including reproductive organs weight, sperm and spermatids numbers and sperm morphology were evaluated. Animals were treated daily with Mikania laevigata syrup (3.5; 7.0 and 14.0mg/kg of coumarin) during 90 days by oral gavage. No alterations were observed in body and organ weights, sperm and spermatids numbers as well as sperm morphology of the male rats after the exposure to the Mikania laevigata syrup. Results therefore suggest absence of male reproductive toxicity of the Mikania laevigata syrup at tested doses.
authors.affiliation: Department of Pharmacology, Sector of Biological Sciences, Universidade Federal do Paraná, Centro Politécnico, Jardim das Américas, Curitiba, PR, Brazil.
authors.forename: Carlos
authors.initials: C
authors.lastname: Graça
authors.forename: Cristina Setim
authors.initials: CS
authors.lastname: Freitas
authors.forename: Cristiane Hatsuko
authors.initials: CH
authors.lastname: Baggio
authors.forename: Paulo Roberto
authors.initials: PR
authors.lastname: Dalsenter
authors.forename: Maria Consuelo Andrade
authors.initials: MC
authors.lastname: Marques
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001938:Brazil; D003374:Coumarins / Q000032:analysis; D004305:Dose-Response Relationship, Drug; D004822:Epididymis / Q000187:drug effects; D005298:Fertility / Q000187:drug effects*; D005837:Genitalia, Male / Q000187:drug effects*; D007441:Intubation, Gastrointestinal; D008297:Male; D035742:Mikania; D010276:Parasympatholytics / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D011467:Prostate / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D019141:Respiratory System Agents / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D012669:Seminal Vesicles / Q000187:drug effects; D013076:Sperm Count; D013091:Spermatogenesis / Q000187:drug effects; D013094:Spermatozoa / Q000187:drug effects*; D013737:Testis / Q000187:drug effects; D013997:Time Factors
chemical_list: D003374:Coumarins; D010276:Parasympatholytics; D010936:Plant Extracts; D019141:Respiratory System Agents; C030123:coumarin