title: Impact of comorbid anxiety disorders on health-related quality of life among patients with major depressive disorder.
abstract: OBJECTIVE
  This study examined the impact of comorbid anxiety disorders-posttraumatic stress disorder (PTSD), generalized anxiety disorder, and panic disorder-on health-related quality of life among primary care patients enrolled in a collaborative care depression intervention study for the Department of Veterans Affairs (VA).
  
  
  METHODS
  Baseline data were used from 324 participants in the Telemedicine Enhanced Antidepressant Management (TEAM) Study, a multisite randomized effectiveness trial targeting VA primary care patients with depression. Health-related quality of life was measured by using the Quality of Well-Being Scale, self-administered version (QWB-SA) and the mental component summary (MCS-12V) and physical component summary (PCS-12V) of the 12-item Short Form Health Survey for Veterans (SF-12V).
  
  
  RESULTS
  A majority of participants (69 percent) had at least one anxiety disorder. Generalized anxiety disorder and PTSD predicted scores on the QWB-SA. PTSD predicted scores on the PCS-12V, but none of the comorbid anxiety disorders predicted scores on the MCS-12V. In addition, social support, depression severity, and the number of chronic medical conditions significantly predicted QWB-SA scores; the number of self-reported chronic physical health conditions and the number of depression episodes significantly predicted PCS-12V scores; and social support and depression severity significantly predicted MCS-12V scores.
  
  
  CONCLUSIONS
  According to scores on the QWB-SA, generalized anxiety disorder and PTSD comorbid with major depressive disorder impair health-related quality of life above and beyond major depressive disorder alone.
authors.affiliation: Health Services Research and Development Center for Mental Healthcare and Outcomes Research, Central Arkansas Veterans Healthcare System, 2200 Fort Roots Drive, Building 58 (152/NLR), Little Rock, AR 72114, USA. dmittal@uams.edu
authors.forename: Dinesh
authors.initials: D
authors.lastname: Mittal
authors.forename: John C
authors.initials: JC
authors.lastname: Fortney
authors.forename: Jeffrey M
authors.initials: JM
authors.lastname: Pyne
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Edlund
authors.forename: Julie L
authors.initials: JL
authors.lastname: Wetherell
mesh_terms: D001008:Anxiety Disorders / Q000453:epidemiology / Q000523:psychology*; D002908:Chronic Disease; D015897:Comorbidity; D003865:Major Depressive Disorder / Q000453:epidemiology / Q000523:psychology*; D005260:Female; D006304:Health Status; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D015995:Prevalence; D011788:Quality of Life / Q000523:psychology*; D012720:Severity of Illness Index; D012944:Social Support; D013313:Stress Disorders, Post-Traumatic / Q000453:epidemiology / Q000523:psychology; D014481:United States; D014493:United States Department of Veterans Affairs