Effects of carprofen on renal function during medetomidine-propofol-isoflurane anesthesia in dogs.
OBJECTIVE
To investigate effects of carprofen on indices of renal function and results of serum bio-chemical analyses and effects on cardiovascular variables during medetomidine-propofol-isoflurane anesthesia in dogs.


METHODS
8 healthy male Beagles.


METHODS
A randomized crossover study was conducted with treatments including saline (0.9% NaCl) solution (0.08 mL/kg) and carprofen (4 mg/kg) administered IV. Saline solution or carprofen was administered 30 minutes before induction of anesthesia and immediately before administration of medetomidine (20 microg/kg, IM). Anesthesia was induced with propofol and maintained with inspired isoflurane in oxygen. Blood gas concentrations and ventilation were measured. Cardiovascular variables were continuously monitored via pulse contour cardiac output (CO) measurement. Renal function was assessed via glomerular filtration rate (GFR), renal blood flow (RBF), scintigraphy, serum biochemical analyses, urinalysis, and continuous CO measurements. Hematologic analysis was performed.


RESULTS
Values did not differ significantly between the carprofen and saline solution groups. For both treatments, sedation and anesthesia caused changes in results of serum biochemical and hematologic analyses; a transient, significant increase in urine alkaline phosphatase activity; and blood flow diversion to the kidneys. The GFR increased significantly in both groups despite decreased CO, mean arterial pressure, and absolute RBF variables during anesthesia.


CONCLUSIONS
Carprofen administered IV before anesthesia did not cause detectable, significant adverse effects on renal function during medetomidine-propofol-isoflurane anesthesia in healthy Beagles.
Frendin
Jan H M
JH
Department of Clinical Sciences, Faculty of Veterinary Medicine and Animal Science, University of Agricultural Sciences, SE-750 07 Uppsala, Sweden.
Boström
Ingrid M
IM
Kampa
Naruepon
N
Eksell
Per
P
Häggström
Jens U
JU
Nyman
Görel C
GC
D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage / Q000494:pharmacology; D018685:Anesthetics, Inhalation / Q000008:administration & dosage / Q000494:pharmacology; D018686:Anesthetics, Intravenous / Q000008:administration & dosage / Q000494:pharmacology; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000494:pharmacology*; D001784:Blood Gas Analysis / Q000662:veterinary; D002227:Carbazoles / Q000008:administration & dosage / Q000494:pharmacology*; D002319:Cardiovascular System / Q000187:drug effects; D003404:Creatinine / Q000097:blood / Q000652:urine; D018592:Cross-Over Studies; D004285:Dogs / Q000502:physiology*; D005919:Glomerular Filtration Rate / Q000187:drug effects; D007530:Isoflurane / Q000008:administration & dosage / Q000494:pharmacology; D007668:Kidney / Q000187:drug effects* / Q000502:physiology; D008297:Male; D020926:Medetomidine / Q000008:administration & dosage / Q000494:pharmacology; D015742:Propofol / Q000008:administration & dosage / Q000494:pharmacology; D012119:Respiration / Q000187:drug effects; D013997:Time Factors
D018712:Analgesics, Non-Narcotic; D018685:Anesthetics, Inhalation; D018686:Anesthetics, Intravenous; D000894:Anti-Inflammatory Agents, Non-Steroidal; D002227:Carbazoles; D003404:Creatinine; D007530:Isoflurane; C007005:carprofen; D020926:Medetomidine; D015742:Propofol