title: Phenol-directed enantioselective allylation of aldimines and ketimines.
abstract: [Structure: see text] Phenols are effective directing and activating groups for our allylchlorosilane reagents, allowing the highly enantioselective allylation of a range of 2-aminophenol-derived aldimines. When the phenol is incorporated into the substrate ketimines may be allylated highly enantioselectively, leading to the experimentally simple synthesis of a range of tertiary carbinamine structures.
authors.affiliation: Department of Chemistry, Columbia University, New York, New York 10027, USA.
authors.forename: Philippe M A
authors.initials: PM
authors.lastname: Rabbat
authors.forename: S Corey
authors.initials: SC
authors.lastname: Valdez
authors.forename: James L
authors.initials: JL
authors.lastname: Leighton
mesh_terms: D000478:Alkylation; D007097:Imines / Q000737:chemistry*; D010636:Phenols / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D007097:Imines; D010636:Phenols