Microbial transformation of dehydrocostuslactone by Mucor polymorphosporus.
Biotransformation of dehydrocostuslactone (1) by Mucor polymorphosporus yielded four compounds, and their structures were identified as 11alpha,13-dihydrodehydrocostuslactone (2), 3alpha-hydroxy-11alpha,13-dihydrodehydrocostuslactone (3), 3beta-hydroxy-4beta,15,11alpha,13-tetrahydrodehydrocostuslactone (4) and 2beta-hydroxyl-11alpha,13-dihydrodehydrocostuslactone (5), respectively, on the basis of their spectral data. Among them, compound 5 is a new compound.
Ma
X-C
XC
The State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, China.
Wu
L-J
LJ
Guo
D-A
DA
D019659:Asteraceae / Q000737:chemistry*; D001711:Biotransformation; D007783:Lactones / Q000737:chemistry* / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009089:Mucor / Q000378:metabolism*; D010946:Plants, Medicinal / Q000378:metabolism*; D012717:Sesquiterpenes / Q000378:metabolism*; D013045:Species Specificity; D013053:Spectrophotometry
C517912:2beta-hydroxyl-11alpha,13-dihydrodehydrocostuslactone; D007783:Lactones; D012717:Sesquiterpenes; C083030:dehydrocostus lactone