title: [Fasting serum glucose level and gastric cancer risk in a nested case-control study].
abstract: OBJECTIVE
  Diabetes has been reported as a risk factor for several cancers. However, the association between diabetes and gastric cancer has been inconsistent. The aim of this study was to evaluate the association between the fasting serum glucose level and gastric cancer risk in Korea.
  
  
  METHODS
  Among the members of the Korean MultiCenter Cancer Cohort (KMCC) from 1993 to 2004, a total of 100 incident gastric cancer cases were ascertained until December 31, 2002 and 400 controls were matched according to age, sex, and year and area of enrollment. Of the eligible subjects, those without fasting serum glucose level information were excluded, with a total of 64 cases and 236 controls finally selected. On enrollment, all subjects completed a baseline demographic and lifestyle characteristics questionnaire, and had their fasting serum glucose level measured. The Helicobacter pylori infection status was determined by an immunoblot assay using long-term stored serum. The odds ratios (ORs) were estimated using conditional and unconditional logistic regression models adjusted for the H. pylori infection status, smoking, drinking, education, follow-up period and matching variables.
  
  
  RESULTS
  The ORs for risk of gastric cancer according to the serum glucose level were 1.33 [95% CI=0.50-3.53] and 1.66 [95% CI=0.55-5.02] for the categories of 100-125 and 126 mg/dL or greater, respectively, compared to the category of less than 100 mg/dL. No increased risk of gastric cancer according to the serum glucose level was found (p-trend=0.337).
  
  
  CONCLUSIONS
  This study provides no evidence for an association of the serum glucose level with gastric cancer.
authors.affiliation: Department of Preventive Medicine, Seoul National University College of Medicine.
authors.forename: Jae Kwan
authors.initials: JK
authors.lastname: Jun
authors.forename: Jin
authors.initials: J
authors.lastname: Gwack
authors.forename: Sue Kyung
authors.initials: SK
authors.lastname: Park
authors.forename: Yun-Hee
authors.initials: YH
authors.lastname: Choi
authors.forename: Yeonju
authors.initials: Y
authors.lastname: Kim
authors.forename: Aesun
authors.initials: A
authors.lastname: Shin
authors.forename: Soung-Hoon
authors.initials: SH
authors.lastname: Chang
authors.forename: Hai-Rim
authors.initials: HR
authors.lastname: Shin
authors.forename: Keun-Young
authors.initials: KY
authors.lastname: Yoo
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001786:Blood Glucose / Q000032:analysis*; D016022:Case-Control Studies; D005215:Fasting; D005260:Female; D006801:Humans; D007723:Korea / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D012306:Risk; D013274:Stomach Neoplasms / Q000453:epidemiology* / Q000378:metabolism*
chemical_list: D001786:Blood Glucose