[Evaluation of the influence of GSTT1 and GSTM1 null genotypes in head and neck carcinogenesis].
BACKGROUND
To evaluate the influence of GSTM1 and GSTT1 null genotypes in head and neck carcinogenesis.


METHODS
The frequencies of GSTM1 and GSTT1 null genotypes were evaluated by multiplex polymerase chain reaction (PCR) in 45 patients with head and neck squamous cell carcinoma and in 45 control group individuals. Both groups were composed of smokers paired by gender, age and race.


RESULTS
The GSTT1 null genotype was found in 24.4% of the patients and 17.7% of the control group (P= 0.606), while 44.4% of the patients and 48.8% of the control group were bearers of the GSTM1 null genotype (P=0.832). No associations between GSTT1 and GSTMI null genotypes and primary tumor sites were found.


CONCLUSIONS
In our study, it was impossible to establish the influence of the GSTT1 and GSTM1 null genotypes in head and neck carcinogenesis.
Goloni-Bertollo
Eny Maria
EM
Faculdade de Medicina de São José do Rio Preto--FAMERP e no departamento de Biologia da Unidade de Pesquisa em Genética e Biologia Molecular, UPGEM São José do Rio Preto, SP.
Biselli
Joice Matos
JM
Corrêa
Léa Carolina Delima
LC
Maníglia
José Victor
JV
Rossit
Andréa Regina Baptista
AR
Ruiz
Mariângela Torreglosa
MT
Pavarino-Bertelli
Erika Cristina
EC
D002294:Carcinoma, Squamous Cell / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease; D005838:Genotype; D005982:Glutathione Transferase / Q000235:genetics*; D006258:Head and Neck Neoplasms / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics
D005982:Glutathione Transferase; C413545:glutathione S-transferase T1