title: Evaluation of immunogenicity and tolerability of a live attenuated hepatitis a vaccine in Indian children.
abstract: An open non comparative study of a live attenuated H2 strain Hepatitis A vaccine of Chinese origin was carried out in 143 healthy Indian children aged 1 to 12 years (mean age 4.87 2.76 years; 88 boys, 55 girls). At baseline, all were negative for IgG HAV antibodies and had normal hematological and biochemical indices. Two months after a single dose of the vaccine (given subcutaneously), 137 children (i.e. 95.8 %) developed protective antibodies of IgG > 20 mIU / mL. The hematological and biochemical parameters remained within normal limits. There were no adverse events in any except mild fever in one child. In conclusion, live attenuated H2 strain Hepatitis A vaccine in a single dose was found to be immunogenic and safe in Indian children.
authors.affiliation: Department of Pediatrics, KEM Hospital, Pune 411 011, India. kemhrc@vsnl.com
authors.forename: Sheila
authors.initials: S
authors.lastname: Bhave
authors.forename: Ashish
authors.initials: A
authors.lastname: Bavdekar
authors.forename: Zinobia
authors.initials: Z
authors.lastname: Madan
authors.forename: Rasendrakumar
authors.initials: R
authors.lastname: Jha
authors.forename: Shraddha
authors.initials: S
authors.lastname: Bhure
authors.forename: Jayant
authors.initials: J
authors.lastname: Chaudhari
authors.forename: Anand
authors.initials: A
authors.lastname: Pandit
mesh_terms: D002648:Child; D002675:Child, Preschool; D005260:Female; D022362:Hepatitis A Vaccines / Q000009:adverse effects / Q000276:immunology*; D018937:Hepatitis C Antibodies / Q000097:blood; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007194:India; D007223:Infant; D008297:Male; D012449:Safety; D014613:Vaccines, Attenuated
chemical_list: D022362:Hepatitis A Vaccines; D018937:Hepatitis C Antibodies; D007074:Immunoglobulin G; D014613:Vaccines, Attenuated