Realizing the cosmetic potential of topical photodynamic therapy.
Several open studies report the efficacy of topical photodynamic therapy (PDT) for non-melanoma skin cancer (NMSC) and precursor lesions. PDT may also be effective in various inflammatory and infectious dermatoses. As a tissue sparing modality, PDT may be preferable for large and/or multiple lesions and those in sites where disfigurement or poor healing from conventional therapies is a particular risk. Limited comparison data confirms that topical PDT achieves superior cosmesis to conventional therapies in actinic keratoses, squamous cell carcinoma in-situ and basal cell carcinoma. This review assesses the current data and proposes potential future applications for topical PDT including the treatment of photo-damaged skin.
Morton
C A
CA
Department of Dermatology, Falkirk Royal Infirmary, Falkirk, UK. colin.morton@fvah.scot.nhs.uk
D003357:Cosmetic Techniques; D006801:Humans; D010778:Photochemotherapy / Q000379:methods*; D012871:Skin Diseases / Q000188:drug therapy*