Synthesis and biological activity of 5',9-anhydro-3-purine-isonucleosides as potential anti-hepatitis C virus agents.
In order to study structure-activity relationships among the derivatives and congeners of 5',9-anhydro-3-(beta-D-ribofuranosyl)xanthine for anti-hepatitis C virus activity, a series of 5',9-anhydro-purine-isonucleosides with a substituent (s) at 6- or/and 8-position of the purine moiety were synthesized, and their anti-hepatitis C virus activity and cytotoxicity were evaluated and discussed.
Chun
Byoung-Kwon
BK
Pharmasset, Inc., Princeton, New Jersey 08540, USA. kwon.chun@pharmasset.com
Wang
Peiyuan
P
Hassan
Abdalla
A
Du
Jinfa
J
Tharnish
Phillip M
PM
Murakami
Eisuke
E
Stuyver
Lieven
L
Otto
Michael J
MJ
Schinazi
Raymond F
RF
Watanabe
Kyoichi A
KA
D000998:Antiviral Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D002478:Cells, Cultured; D016174:Hepacivirus / Q000187:drug effects*; D006801:Humans; D011684:Purine Nucleosides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D012367:RNA, Viral / Q000187:drug effects; D013329:Structure-Activity Relationship; D014779:Virus Replication / Q000187:drug effects
D000998:Antiviral Agents; D011684:Purine Nucleosides; D012367:RNA, Viral