Connecting cell-cycle activation to neurodegeneration in Drosophila.
Studies in cell-culture systems and in postmortem tissue from human disease have suggested a connection between cell-cycle activation and neurodegeneration. The fruit fly Drosophila melanogaster has recently emerged as a powerful model system in which to model neurodegenerative diseases. Here we review work in the fly that has begun to address some of the important questions regarding the relationship between cell-cycle activation and neurodegeneration in vivo, including recent data implicating cell-cycle activation as a downstream effector of tau-induced neurodegeneration. We suggest how powerful research tools in Drosophila might be utilized to approach fundamental questions that remain.
Khurana
Vikram
V
Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Harvard New Research Building Room 652, 77 Louis Pasteur Avenue, Boston, MA 02115, USA.
Feany
Mel B
MB
D000818:Animals; D002453:Cell Cycle / Q000502:physiology*; D002455:Cell Division; D004195:Disease Models, Animal; D004330:Drosophila / Q000502:physiology*; D009410:Nerve Degeneration / Q000473:pathology*; D009474:Neurons / Q000166:cytology / Q000473:pathology / Q000502:physiology; D015398:Signal Transduction; D024801:Tauopathies / Q000473:pathology