title: High seroprevalence of Epstein-Barr virus in children with multiple sclerosis.
abstract: We studied seroprevalence and concentrations of Epstein-Barr virus (EBV) antibodies in 147 pediatric patients with multiple sclerosis (MS) and paired controls. The children with MS showed a near-complete seropositivity for EBV antibody against virus capsid antigen (98.6% vs 72.1% in controls, p = 0.001) but did not display serologic evidence for a recent EBV infection. EBV antibody concentrations of pediatric patients with MS were significantly higher vs controls.
authors.affiliation: Brauweg 19, 37073 Goettingen, Germany. dani.pohl@gmx.net
authors.forename: D
authors.initials: D
authors.lastname: Pohl
authors.forename: B
authors.initials: B
authors.lastname: Krone
authors.forename: K
authors.initials: K
authors.lastname: Rostasy
authors.forename: E
authors.initials: E
authors.lastname: Kahler
authors.forename: E
authors.initials: E
authors.lastname: Brunner
authors.forename: M
authors.initials: M
authors.lastname: Lehnert
authors.forename: H-J
authors.initials: HJ
authors.lastname: Wagner
authors.forename: J
authors.initials: J
authors.lastname: Gärtner
authors.forename: F
authors.initials: F
authors.lastname: Hanefeld
mesh_terms: D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000097:blood; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D020031:Epstein-Barr Virus Infections / Q000453:epidemiology / Q000821:virology; D005260:Female; D005858:Germany / Q000453:epidemiology; D004854:Herpesvirus 4, Human / Q000302:isolation & purification* / Q000378:metabolism; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D009103:Multiple Sclerosis / Q000453:epidemiology / Q000821:virology*; D016036:Seroepidemiologic Studies
chemical_list: D000914:Antibodies, Viral