Emergence and dissemination of Enterobacteriaceae isolates producing CTX-M-1-like enzymes in Spain are associated with IncFII (CTX-M-15) and broad-host-range (CTX-M-1, -3, and -32) plasmids.
The spread of CTX-M-1-like enzymes in Spain is associated with particular plasmids of broad-host-range IncN (blaCTX-M-32, blaCTX-M-1), IncL/M (blaCTX-M-1), and IncA/C2 (blaCTX-M-3) or narrow-host-range IncFII (blaCTX-M-15). The identical genetic surroundings of blaCTX-M-32 and blaCTX-M-1 and their locations on related 40-kb IncN plasmids indicate the in vivo evolution of this element.
Novais
Angela
A
Servicio de Microbiología, Hospital Universitario Ramón y Cajal, IMSALUD, Carretera de Colmenar, km. 9.1, Madrid 28034, Spain.
Cantón
Rafael
R
Moreira
Raquel
R
Peixe
Luísa
L
Baquero
Fernando
F
Coque
Teresa M
TM
D024881:Drug Resistance, Bacterial; D004755:Enterobacteriaceae / Q000201:enzymology* / Q000235:genetics / Q000302:isolation & purification; D019143:Evolution, Molecular; D006801:Humans; D010957:Plasmids; D013030:Spain; D001618:beta-Lactamases / Q000096:biosynthesis / Q000235:genetics / Q000378:metabolism
C473109:beta-lactamase CTX-M-15; C417271:beta-lactamase CTX-M-3; C055184:beta-lactamase TEM-3; D001618:beta-Lactamases; C487656:beta-lactamase CTX-M-32, E coli