title: Two-dimensional population map of cortical connections in the human internal capsule.
abstract: OBJECTIVE
  To exploit diffusion imaging tractography to produce a two-dimensional (xy) probabilistic population map of the cortical connections within the human internal capsule (IC).
  
  
  METHODS
  Diffusion tensor imaging (DTI) was carried out on 11 healthy volunteers. We parceled an axial section of the IC according to its connections to the prefrontal, premotor, primary motor, primary somatosensory, posterior parietal, and occipital cortices using our locally developed probabilistic algorithm.
  
  
  RESULTS
  A consistent topographical organization was generated that was consistent with our anatomical knowledge of the IC. In addition, our study shows that in humans the anterior half of the IC is occupied by the prefrontal cortex.
  
  
  CONCLUSIONS
  This map may be of clinical use for correlating neurological deficit with hemispheric lesions, particularly those that affect sensorimotor function.
authors.affiliation: Centre for Functional MRI of the Brain, Department of Clinical Neurology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom. mojtaba@fmrib.ox.ac
authors.forename: Mojtaba
authors.initials: M
authors.lastname: Zarei
authors.forename: Heidi
authors.initials: H
authors.lastname: Johansen-Berg
authors.forename: Mark
authors.initials: M
authors.lastname: Jenkinson
authors.forename: Olga
authors.initials: O
authors.lastname: Ciccarelli
authors.forename: Alan J
authors.initials: AJ
authors.lastname: Thompson
authors.forename: Paul M
authors.initials: PM
authors.lastname: Matthews
mesh_terms: D000328:Adult; D000465:Algorithms; D001931:Brain Mapping / Q000379:methods*; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D017352:Echo-Planar Imaging; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D020772:Internal Capsule / Q000033:anatomy & histology*; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results