title: DNA replication in the archaea.
abstract: The archaeal DNA replication machinery bears striking similarity to that of eukaryotes and is clearly distinct from the bacterial apparatus. In recent years, considerable advances have been made in understanding the biochemistry of the archaeal replication proteins. Furthermore, a number of structures have now been obtained for individual components and higher-order assemblies of archaeal replication factors, yielding important insights into the mechanisms of DNA replication in both archaea and eukaryotes.
authors.affiliation: MRC Cancer Cell Unit, Hutchison MRC Research Centre, Hills Road, Cambridge CB2 2XZ, United Kingdom.
authors.forename: Elizabeth R
authors.initials: ER
authors.lastname: Barry
authors.forename: Stephen D
authors.initials: SD
authors.lastname: Bell
mesh_terms: D001105:Archaea / Q000201:enzymology / Q000235:genetics*; D002352:Carrier Proteins / Q000378:metabolism; D004261:DNA Replication; D019641:DNA, Archaeal / Q000096:biosynthesis; D004259:DNA-Directed DNA Polymerase / Q000378:metabolism; D019848:Gene Expression Regulation, Archaeal / Q000502:physiology; D020745:Genome, Archaeal
chemical_list: D002352:Carrier Proteins; D019641:DNA, Archaeal; D004259:DNA-Directed DNA Polymerase