Haplotype probabilities for multiple-strain recombinant inbred lines.
Recombinant inbred lines (RIL) derived from multiple inbred strains can serve as a powerful resource for the genetic dissection of complex traits. The use of such multiple-strain RIL requires a detailed knowledge of the haplotype structure in such lines. Broman (2005) derived the two- and three-point haplotype probabilities for 2(n)-way RIL; the former required hefty computation to infer the symbolic results, and the latter were strictly numerical. We describe a simpler approach for the calculation of these probabilities, which allowed us to derive the symbolic form of the three-point haplotype probabilities. We also extend the two-point results for the case of additional generations of intermating, including the case of 2(n)-way intermated recombinant inbred populations (IRIP).
Teuscher
Friedrich
F
Research Unit Genetics and Biometry, Research Institute for the Biology of Farm Animals, Dummerstorf, Germany.
Broman
Karl W
KW
D000818:Animals; D003433:Crosses, Genetic; D006239:Haplotypes / Q000235:genetics*; D008390:Markov Chains; D051379:Mice; D008815:Mice, Inbred Strains / Q000235:genetics*; D008957:Models, Genetic; D011336:Probability