title: Outcomes of patients with haematological malignancies admitted to intensive care unit. A comparative review of allogeneic haematopoietic stem cell transplantation data.
abstract: The outcomes of 55 consecutive haemato-oncology patients admitted to the intensive care unit (ICU) were retrospectively analysed. Twenty-eight patients were admitted following haemopoietic stem cell transplantation (HSCT). Thirty-nine patients were admitted with respiratory failure, and all patients required respiratory support. Seventeen patients survived to be discharged from ICU, with an actuarial 1-year survival of 18%. Overall survival between patients who received intensive chemotherapy and those who underwent allogeneic HSCT was not significantly different (19% vs. 10%, P = 0.19). None of the nine myeloablative HSCT recipients survived (median survival: 9 d). Six of the 15 reduced-intensity conditioned HSCT recipients survived beyond 1 year (median survival: 1050 d, range: 438-1437).
authors.affiliation: Haematological Medicine, Kings College London and Kings College Hospital, London, UK.
authors.forename: Ziyi
authors.initials: Z
authors.lastname: Lim
authors.forename: Antonio
authors.initials: A
authors.lastname: Pagliuca
authors.forename: Sylwia
authors.initials: S
authors.lastname: Simpson
authors.forename: Simon
authors.initials: S
authors.lastname: Cottam
authors.forename: Max
authors.initials: M
authors.lastname: Ervine
authors.forename: Aloysius Y L
authors.initials: AY
authors.lastname: Ho
authors.forename: Stephen
authors.initials: S
authors.lastname: Devereux
authors.forename: Ghulam J
authors.initials: GJ
authors.lastname: Mufti
mesh_terms: D000328:Adult; D000368:Aged; D003422:Critical Care; D005260:Female; D019337:Hematologic Neoplasms / Q000150:complications / Q000401:mortality / Q000601:surgery*; D018380:Hematopoietic Stem Cell Transplantation / Q000401:mortality; D017052:Hospital Mortality; D006801:Humans; D007362:Intensive Care Units; D008297:Male; D008875:Middle Aged; D016016:Proportional Hazards Models; D012074:Remission Induction / Q000379:methods; D012131:Respiratory Insufficiency / Q000401:mortality / Q000628:therapy; D012189:Retrospective Studies; D012307:Risk Factors; D015996:Survival Rate; D014184:Transplantation, Homologous; D016896:Treatment Outcome