High-affinity RNA mimicking binding of 2',4'-BNANC towards complementary strands: a comparative study with 2',4'-BNA/LNA.
2',4'-BNA(NC), a bridged nucleic acid analogue, which was designed and synthesized in our laboratory, showed very high binding affinity towards complementary RNA and DNA strands. Its duplex-forming ability towards a single-stranded RNA was similar to or slightly higher than that of 2',4'-BNA and the overall triplex-forming ability against a double-stranded DNA was also better than that of 2',4'-BNA. 2',4'-BNA(NC) exhibited higher RNA selectivity than 2',4'-BNA.
Rahman
S M Abdur
SM
Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan.
Seki
Sayori
S
Utsuki
Kazushige
K
Obika
Satoshi
S
Miyashita
Kazuyuki
K
Imanishi
Takeshi
T
D001952:Bridged-Ring Compounds / Q000737:chemistry*; D004247:DNA / Q000737:chemistry*; D004277:DNA, Single-Stranded / Q000737:chemistry; D009711:Nucleotides / Q000737:chemistry*; D009841:Oligonucleotides / Q000737:chemistry; D012313:RNA / Q000737:chemistry*; D013696:Temperature
D001952:Bridged-Ring Compounds; D004277:DNA, Single-Stranded; D009711:Nucleotides; D009841:Oligonucleotides; C051802:triplex DNA; D012313:RNA; D004247:DNA