Malformations in the offspring of women with thyroid cancer treated with radioiodine for the ablation of thyroid remnants.
BACKGROUND
Since ovarian function is only temporarily compromised by radioiodine therapy, many women with thyroid cancer treated with radioiodine can become pregnant. The present study evaluated the evolution of these pregnancies and the consequences for the offspring.


METHODS
We retrospectively analyzed 78 pregnancies of 66 women submitted to total thyroidectomy, followed by radioiodine therapy 3.75-5.5 GBq (131)I, mean 4.64 GBq). In all patients, conception occurred one year after ablative therapy (mean of 30 months). Age ranged form 19 to 36 years (mean of 30.6 years) at the time of radioiodine treatment and from 23 to 39 years (mean of 32.8 years) at the time of conception.


RESULTS
Four (5.1%) of the 78 pregnancies resulted in spontaneous abortions. Three (4%) of the 74 deliveries were preterm and there was no case of stillbirth. The birthweight was > 2500 g in 94.6% of the children (+/- SD: 3350 +/- 450 g) and only one infant (1.3%) presented an apparent malformation at birth (intraventricular communication). No difference in the age at the time of radioiodine therapy or conception or in radioiodine dose was observed between pregnancies with an unfavorable outcome and those with a favorable outcome.


CONCLUSIONS
We conclude that pregnancies that occur 12 months after ablative therapy are safe.
do Rosário
Pedro Weslley S
PW
Endocrinology and Metabolism Service, Department of Thyroid, Santa Casa de Belo Horizonte, MG. pedrorosario@globo.com
Barroso
Alvaro Luís
AL
Rezende
Leonardo Lamego
LL
Padrão
Eduardo Lanza
EL
Borges
Michelle A Ribeiro
MA
Purisch
Saulo
S
D000014:Abnormalities, Drug-Induced; D000022:Abortion, Spontaneous / Q000139:chemically induced; D002277:Carcinoma / Q000532:radiotherapy* / Q000601:surgery; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007457:Iodine Radioisotopes / Q000009:adverse effects* / Q000627:therapeutic use; D010053:Ovary / Q000528:radiation effects; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000139:chemically induced*; D011256:Pregnancy Outcome; D012189:Retrospective Studies; D013964:Thyroid Neoplasms / Q000532:radiotherapy* / Q000601:surgery; D013965:Thyroidectomy
D007457:Iodine Radioisotopes