A double-blind controlled study of a nonhydroquinone bleaching cream in the treatment of melasma.
BACKGROUND
Melasma is an acquired hypermelanosis predominantly affecting the face of women. It is often recalcitrant to treatment with hypopigmenting agents.


OBJECTIVE
To assess the efficacy of a nonhydroquinone cream (Amelan M) vs. another (Mela-D) as treatment for melasma.


METHODS
Twenty-two French women with bilateral epidermal and/or mixed melasma were enrolled in a split-faced prospective trial lasting 4 months during summer season weeks. Twelve patients applied once-daily Amelan M to one side of the face with sun-protective factor 60 UVA sunscreen each morning and Mela-D once-daily to the other side of the face. Pigmentation was measured objectively using a mexameter and the melasma area and severity index (MASI) were measured subjectively.


RESULTS
The mean decrease of pigmentation was statistically significant on the MASI with both cream and only with Amelan M with the mexameter. Some adverse side effects were observed.


CONCLUSIONS
Amelan M is really more effective than Mela D cream on melasma. Even though some side effects were observed patients preferred the Amelan M-treated side.
Levy
Jean Luc
JL
Centre Laser Dermatologique, Marseille, France. laserder@jeanluclevy.com
Pons
Fredéric
F
Agopian
Lise
L
Besson
Regis
R