title: A simple Tracerlab module modification for automated on-column [11C]methylation and [11C]carboxylation.
abstract: A modification of commercial [11C]methylation module which can be implemented for both on-column [11C]methylation and [11C]carboxylation in the same automated system is described. This module configuration was applied to the solid-phase synthesis of N-[11C]methyl-choline ([11C]choline) and L-(S-methyl-[11C])methionine ([11C]methionine), using [11C]CH(3)I as methylating agent, as well as to the synthesis of [11C]acetate by [11C]carboxylation with [11C]CO2 of methylmagnesium chloride with high and reproducible radiochemical yields in short reaction time, demonstrating to be a fast and reliable tool for the production of these [11C]radiopharmaceuticals for clinical use.
authors.affiliation: Nuclear Medicine Unit, S. Orsola Hospital, Bologna, Italy.
authors.forename: Filippo
authors.initials: F
authors.lastname: Lodi
authors.forename: Silvia
authors.initials: S
authors.lastname: Trespidi
authors.forename: Donato
authors.initials: D
authors.lastname: Di Pierro
authors.forename: Mario
authors.initials: M
authors.lastname: Marengo
authors.forename: Mohsen
authors.initials: M
authors.lastname: Farsad
authors.forename: Stefano
authors.initials: S
authors.lastname: Fanti
authors.forename: Roberto
authors.initials: R
authors.lastname: Franchi
authors.forename: Stefano
authors.initials: S
authors.lastname: Boschi
mesh_terms: D019342:Acetic Acid / Q000138:chemical synthesis; D001331:Automation; D002250:Carbon Radioisotopes / Q000737:chemistry*; D002794:Choline / Q000138:chemical synthesis; D006801:Humans; D007202:Indicators and Reagents; D008715:Methionine / Q000138:chemical synthesis; D008745:Methylation; D049268:Positron-Emission Tomography; D011854:Radiochemistry / Q000295:instrumentation*; D019275:Radiopharmaceuticals / Q000138:chemical synthesis*
chemical_list: D002250:Carbon Radioisotopes; D007202:Indicators and Reagents; D019275:Radiopharmaceuticals; D008715:Methionine; D002794:Choline; D019342:Acetic Acid