title: Association of CHRM2 with IQ: converging evidence for a gene influencing intelligence.
abstract: The cholinergic neurotransmitter system is thought to be involved in many aspects of memory, attention, and higher cognition. In the Collaborative Study on the Genetics of Alcoholism (COGA) sample, we have previously reported linkage and association to the cholinergic muscarinic 2 receptor gene (CHRM2) on chromosome 7 with evoked EEG oscillations (Jones et al. 2004), providing evidence that this gene may be involved in human brain dynamics and cognition. In addition, a small number of genetic markers were genotyped in CHRM2 in the Minnesota Twin and Family Study (Comings et al. 2003) and a Dutch family study (Gosso et al. 2006, in press) and both research groups found evidence that this gene may be involved in intelligence. In the COGA sample, we have extensively genotyped SNPs within and flanking the CHRM2 gene. We find evidence of association with multiple SNPs across CHRM2 and Performance IQ, as measured by the Wechsler Adult Intelligence Scale-Revised (WAIS-R). These results remain significant after taking into account alcohol dependence and depression diagnoses in the sample.
authors.affiliation: Department of Psychiatry, Washington University in St. Louis, 660 South Euclid Ave., Box 8134, St. Louis, MO 63130, USA. dickd@psychiatry.wustl.edu
authors.forename: Danielle M
authors.initials: DM
authors.lastname: Dick
authors.forename: Fazil
authors.initials: F
authors.lastname: Aliev
authors.forename: John
authors.initials: J
authors.lastname: Kramer
authors.forename: Jen C
authors.initials: JC
authors.lastname: Wang
authors.forename: Anthony
authors.initials: A
authors.lastname: Hinrichs
authors.forename: Sarah
authors.initials: S
authors.lastname: Bertelsen
authors.forename: Sam
authors.initials: S
authors.lastname: Kuperman
authors.forename: Marc
authors.initials: M
authors.lastname: Schuckit
authors.forename: John
authors.initials: J
authors.lastname: Nurnberger
authors.forename: Howard J
authors.initials: HJ
authors.lastname: Edenberg
authors.forename: Bernice
authors.initials: B
authors.lastname: Porjesz
authors.forename: Henri
authors.initials: H
authors.lastname: Begleiter
authors.forename: Victor
authors.initials: V
authors.lastname: Hesselbrock
authors.forename: Alison
authors.initials: A
authors.lastname: Goate
authors.forename: Laura
authors.initials: L
authors.lastname: Bierut
mesh_terms: D000437:Alcoholism / Q000235:genetics; D002874:Chromosome Mapping; D002897:Chromosomes, Human, Pair 7; D005190:Family; D005260:Female; D005838:Genotype; D006801:Humans; D007360:Intelligence / Q000235:genetics*; D008297:Male; D020641:Polymorphism, Single Nucleotide; D043585:Receptor, Muscarinic M2 / Q000235:genetics*; D018433:Twin Studies as Topic; D014481:United States; D014888:Wechsler Scales
chemical_list: C487078:CHRM2 protein, human; D043585:Receptor, Muscarinic M2