title: Serial radionuclide angiographic assessment of left ventricular ejection fraction and regional wall motion after mitral valve replacement in patients with rheumatic disease.
abstract: BACKGROUND
  This study was designed to prospectively investigate the effects of total or partial chordal-sparing and chordal-nonsparing mitral valve replacement (MVR) procedures on regional and global ventricular function in a rheumatic population using sequential multiple-gated acquisition scan.
  
  
  METHODS
  One hundred five consecutive patients undergoing different techniques of chordal preservation procedures during MVR are included in this prospective study. Fifteen patients had complete excision of the chordopapillary apparatus (group 1), 34 had total chordal preservation (group 2), and 56 had preservation of the posterior chordopapillary apparatus (group 3). Radionuclide-derived left ventricular ejection fraction (LVEF) and regional wall motion (RWM) studies on 99 survivors were performed preoperatively, at discharge, at 1 year, and at 2 years.
  
  
  RESULTS
  At discharge, there was a decline in LVEF in all the 3 groups. Statistically significant improvement in ejection fraction occurred in the chordal preservation groups (2 and 3) (P < .05) as compared with the nonchordal group immediately and late postoperatively. Only the total chordal group (2) demonstrated complete recovery of LVEF by 2 years postoperatively. Significant and persistent RWM abnormalities were noted in both the nonchordal and posterior chordal groups.
  
  
  CONCLUSIONS
  We conclude that complete retention of the chordopapillary apparatus during MVR provides superior results compared with nonchordal and partial chordal preservation in terms of preservation of LVEF and reduced incidence of abnormal postoperative RWM.
authors.affiliation: Cardiothoracic Centre, All India Institute of Medical Sciences, New Delhi, India. ujjwalchow@rediffmail.com
authors.forename: Ujjwal K
authors.initials: UK
authors.lastname: Chowdhury
authors.forename: Jayanth K H
authors.initials: JK
authors.lastname: Venkataiya
authors.forename: Chetan D
authors.initials: CD
authors.lastname: Patel
authors.forename: Sandeep
authors.initials: S
authors.lastname: Seth
authors.forename: Rakesh
authors.initials: R
authors.lastname: Yadav
authors.forename: Rajvir
authors.initials: R
authors.lastname: Singh
authors.forename: Ganapathy K
authors.initials: GK
authors.lastname: Subramaniam
authors.forename: Vishwas
authors.initials: V
authors.lastname: Malik
authors.forename: Panangipalli
authors.initials: P
authors.lastname: Venugopal
mesh_terms: D000328:Adult; D002815:Chordae Tendineae / Q000601:surgery; D005260:Female; D015637:Gated Blood-Pool Imaging; D006349:Heart Valve Diseases / Q000000981:diagnostic imaging / Q000401:mortality / Q000503:physiopathology / Q000601:surgery*; D019918:Heart Valve Prosthesis Implantation / Q000379:methods; D006801:Humans; D008297:Male; D008943:Mitral Valve; D011184:Postoperative Period; D011446:Prospective Studies; D012214:Rheumatic Heart Disease / Q000000981:diagnostic imaging / Q000401:mortality / Q000503:physiopathology / Q000601:surgery*; D013318:Stroke Volume; D016896:Treatment Outcome; D016277:Ventricular Function, Left