[Advances in studies on pharmacokinetics of aristolochic acid I].
Aristolochic acid I (AA-I) was absorbed and distributed quickly in vivo, the plasma concentration-time curve were fit with the open two-compartment model and one-compartment model, respectively. The elimination of AA-I has relationship with the dosage, the low dose group eliminates more quickly than the high dose group. The characters of pharmacokinetics of AA-I induce the cumulation of AA-I in vivo and the nephrotoxin to the kidney and other viscera.
Wang
Guan
G
School of Traditional Chinese Material Medica, Shenyang Pharmaceutical University, Shenyang 110016, China.
Wang
Zhi-Min
ZM
Sun
Qi-Shi
QS
D000284:Administration, Oral; D000818:Animals; D030022:Aristolochia / Q000737:chemistry; D034341:Aristolochic Acids / Q000008:administration & dosage / Q000302:isolation & purification / Q000493:pharmacokinetics* / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007275:Injections, Intravenous; D007668:Kidney / Q000378:metabolism*; D007674:Kidney Diseases / Q000139:chemically induced; D007769:Lactams / Q000378:metabolism / Q000633:toxicity; D008099:Liver / Q000378:metabolism; D010946:Plants, Medicinal / Q000737:chemistry; D014018:Tissue Distribution
D034341:Aristolochic Acids; D007769:Lactams; C000228:aristolochic acid I