title: Response of matrix metalloproteinase-9 to olfactory nerve injury.
abstract: Matrix metalloproteinases function in the remodeling of the extracellular matrix during growth and development as well as in injury and disease processes. We examined the role of matrix metalloproteinase-9 in a model of olfactory nerve injury in mice. We measured changes in matrix metalloproteinase-9 protein levels for up to 60 days following olfactory nerve transection. Matrix metalloproteinase-9 levels increased within hours after injury, peaked at day 1 and were elevated for approximately 2 weeks before returning to control levels over the 60-day time period. The increase in matrix metalloproteinase-9 was temporally associated with the degeneration of olfactory neurons that follows nerve transection and with increased gliosis. Our results demonstrate a temporal relationship between matrix metalloproteinase-9 elevation, degeneration of olfactory neurons and gliosis.
authors.affiliation: Department of Physiology, School of Medicine, Virginia Commonwealth University, Richmond, Virginia 23298-0551, USA. rcostanz@vcu.edu
authors.forename: Richard M
authors.initials: RM
authors.lastname: Costanzo
authors.forename: Lisa A
authors.initials: LA
authors.lastname: Perrino
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Kobayashi
mesh_terms: D000818:Animals; D015153:Blotting, Western / Q000379:methods; D004195:Disease Models, Animal; D005786:Gene Expression Regulation / Q000502:physiology*; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D020780:Matrix Metalloproteinase 9 / Q000378:metabolism*; D051379:Mice; D051842:Olfactory Marker Protein / Q000378:metabolism; D020431:Olfactory Nerve Diseases / Q000201:enzymology*; D013997:Time Factors
chemical_list: D005904:Glial Fibrillary Acidic Protein; D051842:Olfactory Marker Protein; D020780:Matrix Metalloproteinase 9