Short and efficient approach towards buxozine-C, an alkaloid from Buxus sempervirens.
Buxus alkaloids display a wide range of interesting pharmacological activities. Here, we present a short and efficient approach towards one of the alkaloids, buxozine-C. The first synthesis has been achieved with 91% yield starting from cyclovirobuxine-D by forming a tetrahydro-oxazine ring with formaldehyde at room temperature.
Liu
Hai-Feng
HF
Institute of Pharmaceutical Engineering, Department of Chemistry and Chemical Engineering, Southeast University, Nanjing, P.R. China.
Ji
Min
M
Cai
Jin
J
D031235:Buxus / Q000737:chemistry*; D005557:Formaldehyde; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D010078:Oxazines / Q000138:chemical synthesis*; D013055:Spectrophotometry, Infrared; D014315:Triterpenes / Q000138:chemical synthesis*; D014934:Wood
D007202:Indicators and Reagents; D010078:Oxazines; D014315:Triterpenes; C517964:buxozine C; D005557:Formaldehyde