title: Exploring cocrystal-cocrystal reactivity via liquid-assisted grinding: the assembling of racemic and dismantling of enantiomeric cocrystals.
abstract: The reaction between pairs of enantiomeric cocrystals involving caffeine or theophylline and a chiral cocrystal former has been investigated by liquid-assisted grinding: we demonstrate two different outcomes for such cocrystal-cocrystal reactions.
authors.affiliation: Pfizer Institute for Pharmaceutical Materials Science, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK.
authors.forename: Tomislav
authors.initials: T
authors.lastname: Friscić
authors.forename: László
authors.initials: L
authors.lastname: Fábián
authors.forename: Jonathan C
authors.initials: JC
authors.lastname: Burley
authors.forename: William
authors.initials: W
authors.lastname: Jones
authors.forename: W D Samuel
authors.initials: WD
authors.lastname: Motherwell
mesh_terms: D002110:Caffeine / Q000737:chemistry*; D003460:Crystallization / Q000379:methods; D018360:Crystallography, X-Ray; D006860:Hydrogen Bonding; D008697:Methane / Q000031:analogs & derivatives / Q000737:chemistry; D008958:Models, Molecular; D015394:Molecular Structure; D009595:Nitroparaffins / Q000737:chemistry; D013237:Stereoisomerism; D013644:Tartrates / Q000737:chemistry*; D013806:Theophylline / Q000737:chemistry*
chemical_list: D009595:Nitroparaffins; D013644:Tartrates; D002110:Caffeine; D013806:Theophylline; D008697:Methane; C008640:nitromethane; C029768:tartaric acid