Photochemical evaluation of dual fluorescence of a novel DNA groove binder.
We synthesized the fluorophore-tethered oligopeptide showing a dual fluorescence in water, and the ratiometric fluorescence change of the modified oligopeptide was induced by the binding to DNA. The equilibrium of the modified oligopeptide between two excited states, a locally excited (LE) state and an intramolecular charge transfer (ICT) state, was controlled depending to DNA structures.
Tanaka
Kazuo
K
Frontier Research System, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.
Tainaka
Kazuki
K
Fujishima
Shohei
S
Okamoto
Akimitsu
A
D004247:DNA / Q000737:chemistry*; D004159:Diphenylamine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D005456:Fluorescent Dyes / Q000138:chemical synthesis / Q000737:chemistry*; D009690:Nucleic Acid Conformation; D009842:Oligopeptides / Q000138:chemical synthesis / Q000737:chemistry*; D010069:Oxadiazoles / Q000138:chemical synthesis / Q000737:chemistry*; D010777:Photochemistry; D013050:Spectrometry, Fluorescence; D014867:Water / Q000737:chemistry
D005456:Fluorescent Dyes; D009842:Oligopeptides; D010069:Oxadiazoles; D014867:Water; D004247:DNA; D004159:Diphenylamine