Oxidative stress and protein oxidation in pseudoexfoliation syndrome.
OBJECTIVE
To investigate the oxidant/antioxidant status and protein oxidation in pseudoexfoliation syndrome.


METHODS
The activity of serum superoxide dismutase (SOD) and the levels of serum malondialdehyde (MDA) and protein carbonyl (PC) were measured in 50 patients with pseudoexfoliation (PEX) and in 55 healthy controls.


RESULTS
There was significant difference in the SOD activity in PEX group compared with the control group (p < 0.001). In addition, MDA and PC levels were significantly higher in patients than in the controls (p < 0.001).


CONCLUSIONS
Decrease in SOD activity and the higher levels of MDA and PC indicate increased oxidative stress. Our results suggest a possible role of oxidative stress in pathology of PEX syndrome.
Yağci
Ramazan
R
Department of Ophthalmology, Fatih University, Medical School, Ankara, Turkey. ramazanyagci@yahoo.com
Gürel
Ahmet
A
Ersöz
Ibrahim
I
Keskin
Uğgur C
UC
Hepşen
Ibrahim F
IF
Duman
Sunay
S
Yiğitoğlu
Ramazan
R
D000368:Aged; D017889:Exfoliation Syndrome / Q000097:blood*; D006801:Humans; D008315:Malondialdehyde / Q000097:blood*; D008875:Middle Aged; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D050050:Protein Carbonylation; D013482:Superoxide Dismutase / Q000097:blood*
D008315:Malondialdehyde; D013482:Superoxide Dismutase