title: A novel hydrogel crosslinked hyaluronan with glycol chitosan.
abstract: A novel hydrogel was prepared by crosslinking hyaluronan with glycol chitosan in aqueous solution using water soluble carbodiimide at nearly neutral pH and room temperature. The products can be easily formulated into injectable gels, various films, membranes and sponges for soft tissue augmentation, viscosupplementation, drug delivery, preventing adhesion of post operation, wound dressing and tissue engineering scaffolds. The said hydrogel has high water adsorption property and biostability. Rheololgical results of the gel showed a soft and viscoelastic structure. FTIR further confirmed the formation of amide bonds between carboxyl groups of hyaluronan and amine groups of glycol chitosan and no N-acylurea and other derivatives were identified.
authors.affiliation: Mentor Biopolymers Ltd Herriot Watt Research Park, Edinburgh, EH14 4AP, United Kingdom. wwang@miswaco.com
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry; D048271:Chitosan / Q000031:analogs & derivatives* / Q000737:chemistry; D003432:Cross-Linking Reagents / Q000737:chemistry; D005022:Ethyldimethylaminopropyl Carbodiimide / Q000031:analogs & derivatives; D006018:Glycols / Q000737:chemistry; D006820:Hyaluronic Acid / Q000737:chemistry; D020100:Hydrogels / Q000737:chemistry; D012996:Solutions; D014867:Water
chemical_list: D001672:Biocompatible Materials; D003432:Cross-Linking Reagents; D006018:Glycols; D020100:Hydrogels; D012996:Solutions; D014867:Water; D006820:Hyaluronic Acid; D048271:Chitosan; D005022:Ethyldimethylaminopropyl Carbodiimide