title: TGF-beta1 gene polymorphism in liver graft recipients.
abstract: Cytokines are known to be important mediators during liver graft outcome and their gene polymorphism could affect the overall expression and secretion of cytokines. In this retrospective study, we analyzed the effect of TGF-beta1 polymorphism in 150 liver allograft recipients. Genotyping PCR-SSP were performed for TGF-beta1 gene (codon 10T/C and 25C/G). TGF-beta1 polymorphism at codon 10 and 25 correlate borderline with liver graft acceptance and when the combination between codon 10 and 25 was analyzed, it revealed that T/T G/C genotype and the TC haplotype were significantly associated with graft acceptance (p<0.05). TGF-beta1 high secretor phenotype was also increased in the acute rejection group close to significance (p=0.06). In conclusion, these findings show a correlation between TGF-beta1 gene polymorphism and liver graft acceptance.
authors.affiliation: Immunology, Hospital Universitario Virgen de la Arrixaca, 30120 Murcia, Spain.
authors.forename: Jorge
authors.initials: J
authors.lastname: Gómez-Mateo
authors.forename: Luis
authors.initials: L
authors.lastname: Marin
authors.forename: María R
authors.initials: MR
authors.lastname: López-Alvarez
authors.forename: M Rosa
authors.initials: MR
authors.lastname: Moya-Quiles
authors.forename: Manuel
authors.initials: M
authors.lastname: Miras
authors.forename: Isabel
authors.initials: I
authors.lastname: Marin-Moreno
authors.forename: Carmen
authors.initials: C
authors.lastname: Botella
authors.forename: Pascual
authors.initials: P
authors.lastname: Parrilla
authors.forename: María R
authors.initials: MR
authors.lastname: Alvarez-López
authors.forename: Manuel
authors.initials: M
authors.lastname: Muro
mesh_terms: D003062:Codon / Q000235:genetics; D005838:Genotype; D006085:Graft Survival / Q000235:genetics / Q000276:immunology; D006239:Haplotypes; D006801:Humans; D016031:Liver Transplantation / Q000276:immunology*; D020641:Polymorphism, Single Nucleotide; D011379:Prognosis; D053773:Transforming Growth Factor beta1 / Q000235:genetics*
chemical_list: D003062:Codon; D053773:Transforming Growth Factor beta1