Hair versus plasma concentrations as indicator of indinavir exposure in HIV-1-infected patients treated with indinavir/ritonavir combination.
Large intra-individual variability in plasma levels may limit the interest of therapeutic drug monitoring based on a single determination. Indinavir concentrations were determined both in plasma and hair samples, and correlated with concomitant plasma HIV-RNA in 43 HIV-infected patients. In multivariate analysis, significant association was found between HIV-RNA below 50 copies/ml and indinavir concentrations in hair but not in plasma, suggesting that hair concentrations gave more extensive information on drug exposure than a single plasma sample.
Duval
Xavier
X
Services des Maladies Infectieuses et Tropicales, Biostatistique et Recherche Clinique, Paris, France.
Peytavin
Gilles
G
Breton
Guillaume
G
Ecobichon
Jean-Luc
JL
Descamps
Diane
D
Thabut
Gabriel
G
Leport
Catherine
C
D023241:Antiretroviral Therapy, Highly Active; D016001:Confidence Intervals; D004338:Drug Combinations; D015658:HIV Infections / Q000097:blood / Q000188:drug therapy*; D015497:HIV-1; D006197:Hair / Q000737:chemistry*; D006801:Humans; D019469:Indinavir / Q000032:analysis* / Q000097:blood / Q000627:therapeutic use; D016017:Odds Ratio; D019438:Ritonavir / Q000032:analysis / Q000097:blood / Q000627:therapeutic use
D004338:Drug Combinations; D019469:Indinavir; D019438:Ritonavir