The expression of TCR-gamma delta/CD3 complex in neoplastic gamma delta T-cell.
We describe that the neoplastic gammadelta T-cells from patients with hepatosplenic gammadelta T-cell lymphoma have a lower expression of TCR-gammadelta/CD3 complex compared to their normal or reactive counterparts. Interestingly, with the use of an appropriate antibody association, this feature is easily and rapidly observed on flow cytometry graphics.
Baseggio
Lucile
L
Berger
Françoise
F
Monneret
Guillaume
G
Magaud
Jean-Pierre
JP
Salles
Gilles
G
Felman
Pascale
P
D017252:CD3 Complex / Q000096:biosynthesis* / Q000097:blood; D015972:Gene Expression Regulation, Neoplastic / Q000276:immunology*; D006801:Humans; D016399:Lymphoma, T-Cell / Q000097:blood* / Q000276:immunology; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000096:biosynthesis* / Q000097:blood
D017252:CD3 Complex; D016692:Receptors, Antigen, T-Cell, gamma-delta