title: Dual infection with HIV and malaria fuels the spread of both diseases in sub-Saharan Africa.
abstract: Mounting evidence has revealed pathological interactions between HIV and malaria in dually infected patients, but the public health implications of the interplay have remained unclear. A transient almost one-log elevation in HIV viral load occurs during febrile malaria episodes; in addition, susceptibility to malaria is enhanced in HIV-infected patients. A mathematical model applied to a setting in Kenya with an adult population of roughly 200,000 estimated that, since 1980, the disease interaction may have been responsible for 8,500 excess HIV infections and 980,000 excess malaria episodes. Co-infection might also have facilitated the geographic expansion of malaria in areas where HIV prevalence is high. Hence, transient and repeated increases in HIV viral load resulting from recurrent co-infection with malaria may be an important factor in promoting the spread of HIV in sub-Saharan Africa.
authors.affiliation: Statistical Center for HIV/AIDS Research and Prevention, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA. laith@scharp.org
authors.forename: Laith J
authors.initials: LJ
authors.lastname: Abu-Raddad
authors.forename: Padmaja
authors.initials: P
authors.lastname: Patnaik
authors.forename: James G
authors.initials: JG
authors.lastname: Kublin
mesh_terms: D000328:Adult; D017954:Africa South of the Sahara / Q000453:epidemiology; D000962:Antimalarials / Q000627:therapeutic use; D004198:Disease Susceptibility; D019353:Endemic Diseases; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000453:epidemiology* / Q000635:transmission / Q000821:virology; D015497:HIV-1 / Q000502:physiology; D006801:Humans; D007630:Kenya / Q000453:epidemiology; D016778:Malaria, Falciparum / Q000150:complications* / Q000188:drug therapy / Q000453:epidemiology* / Q000635:transmission; D008297:Male; D008433:Mathematics; D008954:Models, Biological; D015995:Prevalence; D012008:Recurrence; D012725:Sexual Behavior; D019562:Viral Load; D014766:Viremia; D014779:Virus Replication
chemical_list: D000962:Antimalarials