Intestinal IgA synthesis: a primitive form of adaptive immunity that regulates microbial communities in the gut.
Our intestine is colonized by an impressive community of bacteria, that has profound effects on the immune functions. The relationship between gut microbiota and the immune system is one of reciprocity: bacteria have important contribution in nutrient processing and education of the immune system and conversely, the immune system, particularly gut-associated lymphoid tissues (GALT) plays a key role in shaping the repertoire of gut microbiota. In this review we discuss new insights into the role of IgA in the maintenance of immune homeostasis and the reciprocal interactions between gut B cells and intestinal bacteria.
Suzuki
Keiichiro
K
RIKEN Research Center for Allergy and Immunology, Mucosal Immunity Laboratory, Yokohama, Kanagawa 230-0045, Japan.
Ha
Seon-ah
SA
Tsuji
Masayuki
M
Fagarasan
Sidonia
S
D001402:B-Lymphocytes / Q000276:immunology* / Q000382:microbiology; D001419:Bacteria / Q000276:immunology*; D018407:Bacterial Physiological Phenomena; D041981:Gastrointestinal Tract / Q000276:immunology* / Q000382:microbiology*; D006706:Homeostasis; D006801:Humans; D018928:Immunity, Mucosal; D007070:Immunoglobulin A / Q000096:biosynthesis* / Q000276:immunology* / Q000378:metabolism; D007075:Immunoglobulin M / Q000096:biosynthesis / Q000276:immunology / Q000378:metabolism; D007413:Intestinal Mucosa / Q000276:immunology* / Q000382:microbiology; D010950:Plasma Cells / Q000276:immunology / Q000382:microbiology
D007070:Immunoglobulin A; D007075:Immunoglobulin M