Wolff-Chaikoff effect in a newborn: is it an overlooked problem?
Hypothyroidism is a serious endocrine disorder emerging from deficient production of thyroid hormone (thyroid gland agenesis or dysgenesis, or inborn metabolic defects of thyroid hormone production) or a defect in thyroid hormonal receptor activity. Prevention of iodine organification by means of using iodine-containing drugs or solutions is a protective mechanism for the body and is known as the Wolff-Chaikoff effect. This effect blocks thyroid hormone generation and is often transient, with thyroid hormone synthesis recovering in a few days or weeks. We present a neonate with transient thyroid dysfunction resulting from topical exposure to iodine-containing antiseptic solution. Our aim was to increase awareness that the use of antiseptic iodine solutions in neonates may result in transient hypothyroidism through the Wolff-Chaikoff effect and should be considered after the use of iodine-containing solutions or drugs.
Aliefendioğlu
Didem
D
Department of Pediatrics, Faculty of Medicine, Kirikkale University, Kirikkale 71100, Turkey. didem.aliefendioglu@gmail.com
Sanli
Cihat
C
Cakmak
Murat
M
Ağar
Ayça
A
Albayrak
Meryem
M
Evliyaoğlu
Olcay
O
D000891:Anti-Infective Agents, Local / Q000009:adverse effects*; D005260:Female; D006554:Hernia, Umbilical / Q000601:surgery*; D006801:Humans; D007037:Hypothyroidism / Q000139:chemically induced* / Q000150:complications / Q000175:diagnosis* / Q000378:metabolism; D007231:Infant, Newborn; D017613:Iodine Compounds / Q000009:adverse effects* / Q000378:metabolism; D007565:Jaundice / Q000209:etiology; D013960:Thyroid Function Tests
D000891:Anti-Infective Agents, Local; D017613:Iodine Compounds