title: Four-dimensional measurement of lung tumor displacement using 256-multi-slice CT-scanner.
abstract: The concept of internal target volume is of marked importance for radiotherapy to lung tumors as respiration-induced motion is important. Individualized assessment of motion is required as tumor site may not predict the extent or pattern of tumor motion. We performed volumetric cine scanning using the 256-multi-slice CT (256MSCT) to study tumor motion during free breathing in 14 inpatients who were treated with carbon-ion radiotherapy. Motion assessment in 16 respiratory phases of the cine CT revealed most tumors to show hysteresis-like behavior. Isocenter displacement between peak exhalation and inhalation for the average of the right and left lungs were 7 mm, 7 mm and 15 mm for the upper, middle and lower lobes, respectively. Cine CT with the 256MSCT improved the evaluation of tumor displacement and overcomes some of the limitations associated with current CT methods. Volumetric cine CT data provides useful data on motion for planning in all radiation approaches for lung tumors.
authors.affiliation: Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba, Japan. smori1@partners.org
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Mori
authors.forename: Masahiro
authors.initials: M
authors.lastname: Endo
authors.forename: Shuhei
authors.initials: S
authors.lastname: Komatsu
authors.forename: Tomoyasu
authors.initials: T
authors.lastname: Yashiro
authors.forename: Susumu
authors.initials: S
authors.lastname: Kandatsu
authors.forename: Masayuki
authors.initials: M
authors.lastname: Baba
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology / Q000532:radiotherapy; D008297:Male; D008875:Middle Aged; D009038:Motion; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*; D012119:Respiration; D014057:Tomography, X-Ray Computed / Q000379:methods*