title: Serum lipids, body mass index and waist circumference during pubertal development in Spanish adolescents: the AVENA Study.
abstract: OBJECTIVE
  To describe the effects of chronological age and biological age (pubertal development) on serum lipid and lipoprotein levels, body mass index (BMI) and waist circumference in Spanish adolescents.
  
  
  METHODS
  A representative Spanish sample of 526 adolescents (254 males and 272 females), were studied. Total cholesterol (TC), high density lipoprotein cholesterol (HDLc), triglycerides, apolipoprotein A1 and B, and lipoprotein(a) were measured, and low density lipoprotein cholesterol (LDLc) was calculated. Additional measurements included BMI and waist circumference. Adolescents were classified according to chronological age, and pubertal development (also age of menarche in females).
  
  
  RESULTS
  In males, serum TC levels were lower at late puberty in comparison with early puberty, and serum LDLc levels were lower at late puberty in comparison with mid and early puberty. Serum HDLc levels were lower at mid puberty in comparison with early and late puberty. Serum TC and LDLc levels were not different when analyzed according to chronological age. In females, HDLc levels were lower at late puberty in comparison with early and mid puberty, but no differences were found when HDLc and the other studied lipid and lipoprotein variables were analyzed according to chronological age, or age of menarche. All the observed differences persisted after adjusting for BMI and waist circumference. In female adolescents, both BMI and waist circumference were higher at late puberty in comparison with early and mid puberty, while in males, BMI and waist circumference were different when analyzed according to chronological age.
  
  
  CONCLUSIONS
  The results suggest that the assessment of pubertal development may provide additional valuable information when interpreting lipid profile and body fat in adolescents.
authors.affiliation: Departamento de Fisiología, Facultad de Medicina, Universidad de Granada, Granada, Spain. ruizj@ugr.es
authors.forename: J R
authors.initials: JR
authors.lastname: Ruiz
authors.forename: F B
authors.initials: FB
authors.lastname: Ortega
authors.forename: B
authors.initials: B
authors.lastname: Tresaco
authors.forename: J
authors.initials: J
authors.lastname: Wärnberg
authors.forename: J L
authors.initials: JL
authors.lastname: Mesa
authors.forename: M
authors.initials: M
authors.lastname: González-Gross
authors.forename: L A
authors.initials: LA
authors.lastname: Moreno
authors.forename: A
authors.initials: A
authors.lastname: Marcos
authors.forename: A
authors.initials: A
authors.lastname: Gutiérrez
authors.forename: M J
authors.initials: MJ
authors.lastname: Castillo
mesh_terms: D000293:Adolescent; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D009752:Nutritional Status; D011627:Puberty / Q000097:blood / Q000502:physiology*; D013030:Spain; D049629:Waist-Hip Ratio
chemical_list: D008055:Lipids