title: Central pontine myelinolysis after liver transplantation: MR diffusion, spectroscopy and perfusion findings.
abstract: Magnetic resonance spectroscopy (MRS) and perfusion of central pontine myelinolysis (CPM) have been rarely reported. One case of CPM that developed after liver transplantation was analyzed with serial diffusion-weighted imaging (DWI), MRS and MR perfusion. During the acute phase, a pontine lesion showed an obvious high-signal intensity on DWI with decreased apparent diffusion coefficient value, decreased N-acetylaspartate (NAA)/creatine (Cr) ratio, increased choline (Cho)/Cr ratio and increased perfusion on the cerebral blood volume map. In a later phase, the lesion showed isosignal intensity on DWI, further decreased NAA/Cr ratio, increased Cho/Cr ratio and decreased perfusion. The increase in lesion perfusion during the acute phase may reflect a higher metabolic activity due to an increase in cell number and activity.
authors.affiliation: Department of Radiology, General Navy Hospital, Beijing, China. guoyong27@hotmail.com
authors.forename: Yong
authors.initials: Y
authors.lastname: Guo
authors.forename: Jin-Hua
authors.initials: JH
authors.lastname: Hu
authors.forename: Wei
authors.initials: W
authors.lastname: Lin
authors.forename: Kui-Hong
authors.initials: KH
authors.lastname: Zheng
mesh_terms: D000328:Adult; D038524:Diffusion Magnetic Resonance Imaging; D006801:Humans; D016031:Liver Transplantation / Q000009:adverse effects*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D017590:Myelinolysis, Central Pontine / Q000175:diagnosis* / Q000209:etiology