[Stem cells from human adipose tissue: a new tool for pharmacological studies and for clinical applications].
Multipotent adult stem cells constitute an unlimited source of differentiated cells that could be used in pharmacological studies and in medicine. The presence of stem cells in different tissues, such as bone marrow, skin, muscle, has been reported. However, stem cells are rare in these tissues, are difficult to isolate and to maintain ex vivo. As adipose tissue allows extraction of a large volume of tissue with limited morbidity, this tissue could be an exciting alternative stem cell source. We have recently identified and isolated multipotent stem cells from adipose tissue of young donors. These cells, named human Multipotent Adipose-Derived Stem (hMADS) cells, exhibit features of stem cells, i.e. a high ability to self-renew and the capacity to differentiate in different lineages at the single cell level. The adipocyte differentiation of hMADS cells has been thoroughly studied and differentiated cells exhibit the unique characteristics of human adipocytes. The effects of HIV drugs on the development of hMADS cells into adipocytes will be discussed. Finally, the therapeutic potential of hMADS cells has been revealed after their transplantation into muscles of mdx mice, an animal model of Duchenne muscular dystrophy. Therefore, hMADS cells provides a powerful cellular model for drug screenings and their regenerative properties suggest that these cells could be an important tool for cell-mediated therapy.
Dani
Christian
C
Equipe "Cellules souches et Différenciation", UMR6543 CNRS, Institut de Recherches Signalisation, Biologie du Développement et Cancer, Centre de Biochimie, Parc Valrose, 06108 Nice, France. dani@unice.fr
D052242:Adiponectin / Q000502:physiology; D000273:Adipose Tissue / Q000502:physiology* / Q000503:physiopathology; D002454:Cell Differentiation; D006801:Humans; D020738:Leptin / Q000502:physiology; D039902:Multipotent Stem Cells / Q000502:physiology*; D009765:Obesity / Q000503:physiopathology*; D033581:Stem Cell Transplantation; D014183:Transplantation, Heterologous
D052242:Adiponectin; D020738:Leptin