A family predisposition to adult T-cell leukemia.
We report here the rare case of a family predisposed to adult T-cell leukemia (ATL). Six of seven siblings developed ATL with ages of onset of 77, 48, 60, 64, 72, and 62 years old. Although virological tests for human T-lymphotropic virus type 1 were unavailable for two of the six patients, all were diagnosed with ATL based on their clinical, hematological, and histopathological features. Two of the six patients were tested for HLA haplotypes using fresh blood samples, and both were carriers of the HLA-A*26 allele known in the southern Japanese population to be susceptible to ATL. This series of genetic traits may help explain the familial predisposition to ATL.
Nomura
Kouichiro
K
Internal Medicine, Kagoshima Prefectural Hokusatsu Hospital, Kagoshima, Japan.
Utsunomiya
Atae
A
Furushou
Hironori
H
Tara
Mitsutoshi
M
Hazeki
Masashi
M
Tokunaga
Masayoshi
M
Uozumi
Kimiharu
K
Hanada
Shuichi
S
Yashiki
Shinji
S
Tajima
Kazuo
K
Sonoda
Shunro
S
D000368:Aged; D005260:Female; D020022:Genetic Predisposition to Disease; D015234:HLA-A Antigens / Q000235:genetics*; D015490:HTLV-I Infections / Q000150:complications; D015368:Human T-lymphotropic virus 1; D006801:Humans; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010375:Pedigree
D015234:HLA-A Antigens