Association between paclitaxel and necrotic pancreatitis.
To our knowledge this is the first reported case of paclitaxel associated necrotic pancreatitis requiring a pancreatic necrostomy. This was a near fatal complication associated with paclitaxel with a high resulting morbidity. Although this is a rare association physicians should be wary of the potential to develop severe pancreatitis in patients receiving this therapeautic agent. Monitoring of serum amylase during therapy is therefore warranted.
McMahon
M A
MA
Rheumatology, Beaumont Hospital, Beaumont Road, Dublin 9. mmcm75@yahoo.com
Kearns
G
G
McCaffrey
J
J
Grogan
L
L
D000328:Adult; D000972:Antineoplastic Agents, Phytogenic / Q000009:adverse effects* / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D017239:Paclitaxel / Q000009:adverse effects* / Q000627:therapeutic use; D019283:Pancreatitis, Acute Necrotizing / Q000139:chemically induced*
D000972:Antineoplastic Agents, Phytogenic; D017239:Paclitaxel