Nucleosides as anticancer agents: from concept to the clinic.
The continuing use of nucleosides as anticancer agents is discussed. Examples include the newly approved drug clofarabine as well as 4'-thio-ara-C, a drug that has initiated clinical trials. New directions in anticancer drug discovery will also be discussed.
Secrist
John A
JA
Southern Research Institute, Birmingham, AL, USA.
D000227:Adenine Nucleotides / Q000737:chemistry* / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000627:therapeutic use; D001087:Arabinonucleosides / Q000737:chemistry* / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D000077866:Clofarabine; D015195:Drug Design; D006801:Humans; D009705:Nucleosides / Q000737:chemistry / Q000627:therapeutic use
D000227:Adenine Nucleotides; D000970:Antineoplastic Agents; D001087:Arabinonucleosides; D009705:Nucleosides; D000077866:Clofarabine; C411255:4'-thio-arabinofuranosylcytosine