title: Alpha-hit, cellular dose, cell transformation and inactivation probability distributions of radon progenies in the bronchial epithelium.
abstract: A fluid dynamics based model has been used to determine the deposition patterns of inhaled radon daughters in a realistic approach of the bronchial airway geometry. The interaction of the emitted alpha particles with epithelial cells has been analyzed by applying a complex hit probability model (Bronchial Alpha Hit Model). The biological response of the hit cells has been calculated by the Probability-Per-Unit-Track-Length Model, which relates the probability of a specific biological effect to the track length of alpha particles as a function of the particles' LET. The models mentioned above form a complex lung-radon interaction description. The calculations indicate that compared to the average values the transformation and cell killing probabilities are higher at bronchial carinal ridges. In addition, a considerable number of cells possessing a not negligible transformation and cell killing probabilities can also be found in the outer sides of the central zone.
authors.affiliation: KFKI Atomic Energy Research Institute, 1525 Budapest, Hungary. szoke@sunserv.kfki.hu
authors.forename: István
authors.initials: I
authors.lastname: Szoke
authors.forename: Imre
authors.initials: I
authors.lastname: Balásházy
authors.forename: Arpád
authors.initials: A
authors.lastname: Farkas
authors.forename: Werner
authors.initials: W
authors.lastname: Hofmann
authors.forename: Réka
authors.initials: R
authors.lastname: Szoke
authors.forename: Hatim
authors.initials: H
authors.lastname: Fakir
authors.forename: Erika
authors.initials: E
authors.lastname: Kis
mesh_terms: D000336:Aerosols / Q000009:adverse effects; D000396:Air Pollutants, Radioactive / Q000009:adverse effects; D000512:Alpha Particles; D001980:Bronchi / Q000503:physiopathology / Q000528:radiation effects*; D002470:Cell Survival / Q000528:radiation effects*; D002471:Cell Transformation, Neoplastic / Q000528:radiation effects*; D003198:Computer Simulation; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D018499:Linear Energy Transfer / Q000528:radiation effects; D008954:Models, Biological; D015233:Models, Statistical; D011829:Radiation Dosage; D011832:Radiation Injuries / Q000209:etiology / Q000503:physiopathology*; D011874:Radiometry / Q000379:methods*; D017687:Radon Daughters / Q000009:adverse effects*; D020545:Respiratory Mucosa / Q000503:physiopathology / Q000528:radiation effects*
chemical_list: D000336:Aerosols; D000396:Air Pollutants, Radioactive; D017687:Radon Daughters