Subcutaneous panniculitis-like T-cell lymphoma in a 26-month-old child with a review of the literature.
Subcutaneous panniculitis-like T-cell lymphoma is a rare cytotoxic T-cell lymphoma of the skin that preferentially infiltrates the subcutaneous tissue. We report here this lymphoma occurring in a 26-month-old Korean girl. She presented with multiple erythematous subcutaneous nodules on both extremities and her back along with systemic symptoms. She had a protracted course of multiple erythematous subcutaneous nodules for 1 month and a spiking fever was often noted. The histopathologic findings for the subcutaneous nodules were lobular panniculitis-like material that was composed of atypical lymphocytes and histiocytes. The atypical lymphocytes characteristically rimmed individual fat cells in a lace-like pattern and some of the histiocytes showed phagocytosed white blood cells occasionally. Immunophenotypic studies showed CD3(+), CD45RO(+), CD20(-), CD4(-), CD8(+), and CD56(-). She is currently being treated with combination chemotherapy of cyclophosphamide, doxorubicin, vincristine, and prednisolone.
Yim
Jun Hee
JH
Department of Dermatology, Kangnam St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Kim
Mi-Yeon
MY
Kim
Hyung Ok
HO
Cho
Bin
B
Chung
Nak-Gyun
NG
Park
Young Min
YM
D002675:Child, Preschool; D005260:Female; D006801:Humans; D016399:Lymphoma, T-Cell / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D015434:Panniculitis / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D040521:Subcutaneous Tissue / Q000473:pathology*