Ganglioside-specific IgG and IgA recruit leukocyte effector functions in Guillain-Barré syndrome.
The capacity of ganglioside-specific autoantibodies to recruit leukocyte effector functions was studied. Serum samples from 87 patients with Guillain-Barré (GBS) or Miller Fisher syndrome (MFS), containing GM1-, GQ1b-, or GD1b-specific IgG or IgA, were tested for leukocyte activating capacity. Ganglioside-specific IgG antibodies generally induced leukocyte activation, irrespective of specificity. The magnitude of leukocyte degranulation correlated with GM1- and GQ1b-specific IgG titers, but not with disease severity. Finally, GM1-specific IgA activated leukocytes through the IgA receptor, FcalphaRI (CD89). Therefore, both ganglioside-specific IgG and IgA can recruit leukocyte effector functions, which may be relevant in the pathogenesis of GBS and MFS.
van Sorge
Nina M
NM
Department of Immunology, University Medical Center Utrecht, Lundlaan 6, 3584 EA Utrecht, The Netherlands.
Yuki
Nobuhiro
N
Koga
Michiaki
M
Susuki
Keiichiro
K
Jansen
Marc D
MD
van Kooten
Cees
C
Wokke
John H J
JH
van de Winkel
Jan G J
JG
van der Pol
W-Ludo
WL
van den Berg
Leonard H
LH
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000918:Antibody Specificity; D015703:Antigens, CD / Q000378:metabolism; D001323:Autoantibodies / Q000276:immunology*; D015550:Cell Degranulation; D002648:Child; D002675:Child, Preschool; D005260:Female; D005677:G(M1) Ganglioside / Q000276:immunology; D005732:Gangliosides / Q000276:immunology*; D020275:Guillain-Barre Syndrome / Q000097:blood / Q000276:immunology*; D006801:Humans; D007070:Immunoglobulin A / Q000276:immunology*; D007074:Immunoglobulin G / Q000276:immunology*; D007962:Leukocytes / Q000276:immunology* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D019846:Miller Fisher Syndrome / Q000097:blood / Q000276:immunology; D011961:Receptors, Fc / Q000378:metabolism
D015703:Antigens, CD; D001323:Autoantibodies; C036832:Fc(alpha) receptor; D005732:Gangliosides; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D011961:Receptors, Fc; C033851:ganglioside, GD1b; D005677:G(M1) Ganglioside; C039129:GQ1b ganglioside