Predictive value of p53 and PCNA expression for occult neck metastases in patients with clinically node-negative oral tongue cancer.
OBJECTIVE
In an attempt to identify molecular markers predictive of occult neck metastases, we investigated whether positive p53 or proliferating cell nuclear antigen (PCNA) immunoreactivities on deparaffinized sections of the primary tumor are correlated to the presence of occult neck node metastases in oral tongue cancer patients with clinically negative cervical nodes (N0).


METHODS
Between 1986 and 1997, 37 clinically N0 patients who underwent neck dissection (25 male, 12 female; mean age 54 years) were selected for p53 and PCNA staining.


RESULTS
p53 and PCNA immunoreactivities were detected in 68% and 32%, respectively. There was no correlation between p53 or PCNA and other clinicopathological factors, such as tumor differentiation, tumor type, tumor size, and T-stage. Although tumor differentiation (P=0.03) and tumor size (P=0.03) were significantly correlated with occult neck metastases of oral tongue cancer by univariate analysis, no correlation was found between p53 or PCNA and the presence of occult neck metastasis.


CONCLUSIONS
p53 and/or PCNA expression are unsuitable as biological markers predictive of lymph node metastases of oral tongue cancer.


CONCLUSIONS
p53- or PCNA-positive status are not a reliable parameter for selection of elective neck dissection in the management of N0 oral tongue cancer patients.
Keum
Ki Chang
KC
Department of Radiation Oncology, Yonsei Cancer Center, Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul, and National Health Insurance Cooperation, Ilsan Hospital, Kyonggi, Korea.
Chung
Eun Ji
EJ
Koom
Woong Sub
WS
Cho
Jae Ho
JH
Cho
Sang Ho
SH
Choi
Eun Chang
EC
Lee
Chang Geol
CG
Suh
Chang Ok
CO
Kim
Gwi Eon
GE
D005260:Female; D006258:Head and Neck Neoplasms / Q000378:metabolism* / Q000556:secondary; D006801:Humans; D007150:Immunohistochemistry; D008207:Lymphatic Metastasis / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D037981:Neck Dissection; D011379:Prognosis; D018809:Proliferating Cell Nuclear Antigen / Q000378:metabolism*; D014062:Tongue Neoplasms / Q000378:metabolism* / Q000473:pathology; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*
D018809:Proliferating Cell Nuclear Antigen; D016159:Tumor Suppressor Protein p53