Using enzymatic reactions to enhance the photodynamic therapy effect of porphyrin dityrosine phosphates.
This paper reports the synthesis and photodynamic therapy (PDT) effect of a porphyrin derivative containing tyrosine phosphate, which promises a new, useful approach to develop PDT agents.
Liang
Gaolin
G
Department of Chemistry, The Hong Kong University of Science & Technology, Clear Water Bay, Hong Kong, China.
Wang
Ling
L
Yang
Zhimou
Z
Koon
Hokee
H
Mak
Naiki
N
Chang
Chi K
CK
Xu
Bing
B
D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D004305:Dose-Response Relationship, Drug; D005021:Ethylamines / Q000737:chemistry; D006367:HeLa Cells; D006801:Humans; D008027:Light; D015394:Molecular Structure; D010744:Phosphoric Monoester Hydrolases / Q000737:chemistry* / Q000378:metabolism; D019000:Phosphotyrosine / Q000737:chemistry* / Q000378:metabolism; D010778:Photochemotherapy / Q000379:methods; D017319:Photosensitizing Agents / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D011166:Porphyrins / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D011524:Protoporphyrins / Q000737:chemistry; D013053:Spectrophotometry; D014230:Triazoles / Q000737:chemistry; D014508:Urea / Q000031:analogs & derivatives / Q000737:chemistry
D005021:Ethylamines; D017319:Photosensitizing Agents; D011166:Porphyrins; D011524:Protoporphyrins; D014230:Triazoles; D019000:Phosphotyrosine; C027070:N,N-diisopropylethylamine; D014508:Urea; D010744:Phosphoric Monoester Hydrolases; C074712:2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate