title: [Polymorphisms analysis of short tandem repeat loci D21S1433, D21S1442, D21S1444, D21S2051 in Guangdong Han nationality in China].
abstract: OBJECTIVE
  To investigate the polymorphic distribution of short tandem repeat (STR) sequences D21S1433, D21S1442, D21S1444, D21S2051 in Guangdong Han nationality in China.
  
  
  METHODS
  Using quantitative fluorescens PCR technology, the authors analyzed 200 unrelated samples to acknowledge the allele frequency, heterozygosity and other genetic information.
  
  
  RESULTS
  D21S1433, D21S1442, D21S1444, D21S2051 were tested in 200 samples, which were tested to be statistical according to Hardy-Weinberg equilibrium (P> 0.05), 9, 10, 9 and 5 alleles were detected separately in each STRs. The heterozygosity of each STR was 0.818, 0.820, 0.770, and 0.261. The polymorphic information content > 0.7 in D21S1433, D21S1442, D21S1444, while D21S2051 owned only 0.247 polymorphic information.
  
  
  CONCLUSIONS
  D21S1433, D21S1442, D21S1444 are found to have high heterozygosity and polymorphic information content, and they could provide useful markers for genetic purposes, while D21S2051 is not informative in Guangdong Han nationality in China.
authors.affiliation: Research Center of Prenatal Diagnosis, Women and Children Hospital, Guangzhou, Guangdong, 510180, P. R. China.
authors.forename: Xin
authors.initials: X
authors.lastname: Yang
authors.forename: Can
authors.initials: C
authors.lastname: Liao
authors.forename: Yi-ning
authors.initials: YN
authors.lastname: Huang
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.forename: Cui-xing
authors.initials: CX
authors.lastname: Yi
authors.forename: Sao-qing
authors.initials: SQ
authors.lastname: Wu
authors.forename: Ming
authors.initials: M
authors.lastname: Pan
authors.forename: Sun-yan
authors.initials: SY
authors.lastname: Hu
authors.forename: Si-ming
authors.initials: SM
authors.lastname: Yuan
mesh_terms: D000483:Alleles; D044466:Asian People / Q000235:genetics*; D002681:China; D005260:Female; D005787:Gene Frequency; D005828:Genetics, Population; D006579:Heterozygote; D006801:Humans; D016133:Polymerase Chain Reaction / Q000379:methods; D011110:Polymorphism, Genetic; D011247:Pregnancy; D020080:Tandem Repeat Sequences / Q000235:genetics*