title: Adult stem cell therapy: dream or reality?
abstract: Adult stem cells may be an invaluable source of plastic cells for tissue regeneration. The bone marrow contains different subpopulations of adult stem cells easily accessible for transplantation. However the therapeutic value of adult stem cell is a question of debate in the scientific community. We have investigated the potential benefits of adult hematopoietic stem cell transplantation in animal models of demyelinating and motor neuron diseases. Our results suggest that transplantation of HSC have direct and indirect neuroregenerative and neuroprotective effects.
authors.affiliation: Hospital Morales Meseguer, Servicio de Hematología, Facultad de Medicina, Murcia, Spain. jmoraled@um.es
authors.forename: Jose M
authors.initials: JM
authors.lastname: Moraleda
authors.forename: Miguel
authors.initials: M
authors.lastname: Blanquer
authors.forename: Patricia
authors.initials: P
authors.lastname: Bleda
authors.forename: Paqui
authors.initials: P
authors.lastname: Iniesta
authors.forename: Francisco
authors.initials: F
authors.lastname: Ruiz
authors.forename: Sonia
authors.initials: S
authors.lastname: Bonilla
authors.forename: Carmen
authors.initials: C
authors.lastname: Cabanes
authors.forename: Lucía
authors.initials: L
authors.lastname: Tabares
authors.forename: Salvador
authors.initials: S
authors.lastname: Martinez
mesh_terms: D000818:Animals; D003711:Demyelinating Diseases / Q000628:therapy; D018380:Hematopoietic Stem Cell Transplantation / Q000639:trends*; D006801:Humans; D051379:Mice; D016472:Motor Neuron Disease / Q000628:therapy; D009416:Nerve Regeneration; D009422:Nervous System Diseases / Q000628:therapy*; D019636:Neurodegenerative Diseases / Q000628:therapy