title: A three-component tandem reductive aldol reaction catalyzed by N-heterocyclic carbene-copper complexes.
abstract: [Structure: see text] An efficient catalytic system for the three-component coupling of electrophilic alkenes, aldehydes, and silane was optimized with a new family of copper N-heterocyclic carbene complexes. These catalysts do not require activation and show high activity (TOF>15,000 h-1) as well as some anti diastereoselectivity.
authors.affiliation: Unité de Chimie Organique et Médicinale, Place Louis Pasteur 1, Université catholique de Louvain, 1348 Louvain la Neuve, Belgium.
authors.forename: Alexandre
authors.initials: A
authors.lastname: Welle
authors.forename: Silvia
authors.initials: S
authors.lastname: Díez-González
authors.forename: Bernard
authors.initials: B
authors.lastname: Tinant
authors.forename: Steven P
authors.initials: SP
authors.lastname: Nolan
authors.forename: Olivier
authors.initials: O
authors.lastname: Riant
mesh_terms: D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D006571:Heterocyclic Compounds / Q000737:chemistry*; D006838:Hydrocarbons / Q000737:chemistry; D008697:Methane / Q000031:analogs & derivatives* / Q000737:chemistry; D008958:Models, Molecular; D010084:Oxidation-Reduction
chemical_list: D006571:Heterocyclic Compounds; D006838:Hydrocarbons; C030011:carbene; D003300:Copper; D008697:Methane