Dynamics of morphofunctional changes in immune organs of BALB/c mice with experimental hepatitis.
The time course of morphofunctional changes in the liver, thymus, and spleen was observed in BALB/c mice with Con A-induced experimental hepatitis. The progress of alterative changes in the liver was paralleled by intensification of accidental involution of the thymus. On day 1 of hepatitis development high proliferative and cytostatic activity of splenocytes was paralleled by hemorrhagic necroses and depletion of the peri-arteriolar lymphoid sheaths in the spleen (T-zones), presumably due to migration of activated lymphocytes to the liver and barrier tissues. Later normalization of lymphocyte proliferative activity was paralleled by recovery and hyperplasia of the splenic T-cell zones.
Obernikhin
S S
SS
Institute of Human Morphology, Russian Academy of Medical Sciences, Moscow. ober@mail.ru
Makarova
O V
OV
Malaitsev
V V
VV
Bogdanova
I M
IM
Boltovskaya
M N
MN
D000818:Animals; D049109:Cell Proliferation; D004195:Disease Models, Animal; D006505:Hepatitis / Q000276:immunology*; D022781:Hepatocytes / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000378:metabolism; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009336:Necrosis; D013154:Spleen / Q000166:cytology; D013950:Thymus Gland / Q000378:metabolism