Progression from impaired fasting glucose and impaired glucose tolerance to diabetes in a high-risk screening programme in general practice: the ADDITION Study, Denmark.
OBJECTIVE
To estimate the 1-year progression rates from both IFG and IGT to diabetes in individuals identified in a pragmatic diabetes screening programme in general practice (the ADDITION Study, Denmark [Anglo-Danish-Dutch Study of Intensive Treatment in People with Screen-Detected Diabetes in Primary Care]).


METHODS
Persons aged 40-69 years were screened for type 2 diabetes based on a high-risk, stepwise strategy. At baseline, anthropometric measurements, blood samples and questionnaire data were collected. A total of 1,160 persons had IFG or IGT at baseline: 811 (70%) accepted re-examination after 1 year. Glucose tolerance classification was based on the 1999 WHO definition. At follow-up, diabetes was based on one diabetic glucose value of fasting blood glucose or 2-h blood glucose.


RESULTS
At baseline, 308 persons had IFG and 503 had IGT. The incidence of diabetes was 17.6 and 18.8 per 100 person-years in the two groups, respectively.


CONCLUSIONS
IFG and IGT identified in general practice during a stepwise, high-risk screening programme for type 2 diabetes have high 1-year progression rates to diabetes. Consequently, intensive follow-up and intervention strategies are recommended for these high-risk individuals.
Rasmussen
S S
SS
Steno Diabetes Center, Niels Steensensvej 2, DK-2820, Gentofte, Denmark. SSSR@steno.dk
Glümer
C
C
Sandbaek
A
A
Lauritzen
T
T
Borch-Johnsen
K
K
D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D003718:Denmark / Q000453:epidemiology; D003920:Diabetes Mellitus / Q000453:epidemiology* / Q000235:genetics; D018450:Disease Progression; D005194:Family Practice / Q000706:statistics & numerical data; D018149:Glucose Intolerance / Q000453:epidemiology* / Q000503:physiopathology*; D006801:Humans; D008403:Mass Screening; D008875:Middle Aged; D012307:Risk Factors
D001786:Blood Glucose