New insights into the regulation of liver inflammation and oxidative stress.
Pro-inflammatory lipid mediators (i.e. eicosanoids), cytokines (i.e. TNF-alpha) and reactive oxygen species are targets of interest in the regulation of liver inflammation and oxidative stress. In the current review, we summarize recent advances in the pharmacological modulation of these pathways with especial emphasis on the participation of Kupffer cells, the liver resident macrophages and the cell type most directly related to the production of inflammatory mediators in this organ.
Ferré
Natàlia
N
Department of Biochemistry and Molecular Genetics, Hospital Clínic, Villarroel 170, Barcelona 08036, Spain. nferrep@clinic.ub.es
Clària
Joan
J
D000818:Animals; D016718:Arachidonic Acid / Q000378:metabolism; D016207:Cytokines / Q000378:metabolism; D006505:Hepatitis / Q000378:metabolism / Q000503:physiopathology*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism; D007728:Kupffer Cells / Q000378:metabolism; D018384:Oxidative Stress; D016212:Transforming Growth Factor beta / Q000378:metabolism
D016207:Cytokines; D036341:Intercellular Signaling Peptides and Proteins; D016212:Transforming Growth Factor beta; D016718:Arachidonic Acid