Sirtuins: a conserved key unlocking AceCS activity.
Bacterial acetyl-coenzyme A (acetyl-CoA) synthetase (AceCS), an evolutionarily conserved enzyme that converts acetate to acetyl-CoA, is activated by sirtuin-mediated deacetylation. Two recent studies show that this mechanism of regulation is also crucial for mammalian AceCS activity, indicating that control of metabolism at the step of converting acetate to acetyl-CoA is conserved. These findings highlight a metabolic regulatory network controlled by sirtuins that has implications for the mechanisms of calorie restriction and modulation of mammalian lifespan.
North
Brian J
BJ
Department of Pathology, Paul F. Glenn Laboratories for the Biological Mechanisms of Aging, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA. brian_north@hms.harvard.edu
Sinclair
David A
DA
D000106:Acetate-CoA Ligase / Q000378:metabolism*; D000818:Animals; D031204:Caloric Restriction; D005943:Gluconeogenesis / Q000187:drug effects; D006801:Humans; D051379:Mice; D024101:Mitochondrial Proteins / Q000502:physiology; D056564:Sirtuin 1; D056566:Sirtuin 3; D037761:Sirtuins / Q000502:physiology*
D024101:Mitochondrial Proteins; C466093:SIRT3 protein, human; C470545:Sirt1 protein, mouse; D056564:Sirtuin 1; D056566:Sirtuin 3; D037761:Sirtuins; D000106:Acetate-CoA Ligase