title: Discovery of (Z)-2-phenyl-3-(1H-pyrrol-2-yl)acrylonitrile derivatives active against Haemonchus contortus and Ctenocephalides felis (cat flea).
abstract: A series of 2-phenyl-3-(1H-pyrrol-2-yl)acrylonitrile derivatives were synthesized and evaluated for in vitro activity against the endoparasite Haemonchus contortus and the ectoparasite Ctenocephalides felis. Some compounds had significant in vitro activity against these parasites.
authors.affiliation: CSIRO, Molecular and Health Technologies, Bayview Avenue, Clayton, Vic. 3168, Australia.
authors.forename: Abdelselam
authors.initials: A
authors.lastname: Ali
authors.forename: Marianne
authors.initials: M
authors.lastname: Bliese
authors.forename: Jo-Anne M
authors.initials: JA
authors.lastname: Rasmussen
authors.forename: Roger M
authors.initials: RM
authors.lastname: Sargent
authors.forename: Simon
authors.initials: S
authors.lastname: Saubern
authors.forename: David G
authors.initials: DG
authors.lastname: Sawutz
authors.forename: John S
authors.initials: JS
authors.lastname: Wilkie
authors.forename: David A
authors.initials: DA
authors.lastname: Winkler
authors.forename: Kevin N
authors.initials: KN
authors.lastname: Winzenberg
authors.forename: Ruth C J
authors.initials: RC
authors.lastname: Woodgate
mesh_terms: D000181:Acrylonitrile / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D000818:Animals; D000969:Antinematodal Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D000977:Antiparasitic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002415:Cats; D006189:Haemonchus / Q000187:drug effects*; D007306:Insecticides / Q000138:chemical synthesis* / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D005423:Siphonaptera / Q000502:physiology*; D013329:Structure-Activity Relationship
chemical_list: C518728:(Z)-2-phenyl-3-(1H-pyrrol-2-yl)acrylonitrile; D000969:Antinematodal Agents; D000977:Antiparasitic Agents; D007306:Insecticides; D000181:Acrylonitrile