title: [Evaluation of the influence of GSTT1 and GSTM1 null genotypes in head and neck carcinogenesis].
abstract: BACKGROUND
  To evaluate the influence of GSTM1 and GSTT1 null genotypes in head and neck carcinogenesis.
  
  
  METHODS
  The frequencies of GSTM1 and GSTT1 null genotypes were evaluated by multiplex polymerase chain reaction (PCR) in 45 patients with head and neck squamous cell carcinoma and in 45 control group individuals. Both groups were composed of smokers paired by gender, age and race.
  
  
  RESULTS
  The GSTT1 null genotype was found in 24.4% of the patients and 17.7% of the control group (P= 0.606), while 44.4% of the patients and 48.8% of the control group were bearers of the GSTM1 null genotype (P=0.832). No associations between GSTT1 and GSTMI null genotypes and primary tumor sites were found.
  
  
  CONCLUSIONS
  In our study, it was impossible to establish the influence of the GSTT1 and GSTM1 null genotypes in head and neck carcinogenesis.
authors.affiliation: Faculdade de Medicina de São José do Rio Preto--FAMERP e no departamento de Biologia da Unidade de Pesquisa em Genética e Biologia Molecular, UPGEM São José do Rio Preto, SP.
authors.forename: Eny Maria
authors.initials: EM
authors.lastname: Goloni-Bertollo
authors.forename: Joice Matos
authors.initials: JM
authors.lastname: Biselli
authors.forename: Léa Carolina Delima
authors.initials: LC
authors.lastname: Corrêa
authors.forename: José Victor
authors.initials: JV
authors.lastname: Maníglia
authors.forename: Andréa Regina Baptista
authors.initials: AR
authors.lastname: Rossit
authors.forename: Mariângela Torreglosa
authors.initials: MT
authors.lastname: Ruiz
authors.forename: Erika Cristina
authors.initials: EC
authors.lastname: Pavarino-Bertelli
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease; D005838:Genotype; D005982:Glutathione Transferase / Q000235:genetics*; D006258:Head and Neck Neoplasms / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics
chemical_list: D005982:Glutathione Transferase; C413545:glutathione S-transferase T1