title: Efficacy of sertraline in posttraumatic stress disorder secondary to interpersonal trauma or childhood abuse.
abstract: BACKGROUND
  In posttraumatic stress disorder (PTSD), the nature of the trauma and the age of occurrence may have substantial effects on psychobiological sequelae and treatment response. Interpersonal trauma (physical/sexual assault) and childhood abuse are both prevalent and associated with later PTSD. This analysis was conducted to specifically assess the efficacy of sertraline in the treatment of PTSD secondary to interpersonal trauma or childhood abuse.
  
  
  METHODS
  395 adult patients with PTSD were randomized to 12-weeks double-blind treatment with flexible dose sertraline (50-200 mg/d) or placebo. Patients with different index traumas were compared in terms of baseline demographic and clinical characteristics, as well as treatment response. Primary efficacy variables included part 2 of the Clinician Administered PTSD Scale (CAPS-2).
  
  
  RESULTS
  Interpersonal trauma and childhood abuse were both more common in females than males, and were associated with early age at time of index trauma and longer duration of PTSD, but not with PTSD symptom severity. Sertraline was significantly more effective than placebo on most primary efficacy variables, irrespective of whether patients had experienced interpersonal trauma or childhood abuse.
  
  
  CONCLUSIONS
  These data demonstrate that sertraline is valuable for the treatment of PTSD, irrespective of whether the precipitating trauma involves interpersonal trauma in general, or childhood abuse in particular.
authors.affiliation: Department of Psychiatry, University of Cape Town, Cape Town, South Africa. dan.stein@curie.uct.ac.za
authors.forename: Dan J
authors.initials: DJ
authors.lastname: Stein
authors.forename: Bessel A
authors.initials: BA
authors.lastname: van der Kolk
authors.forename: Carol
authors.initials: C
authors.lastname: Austin
authors.forename: Rana
authors.initials: R
authors.lastname: Fayyad
authors.forename: Cathryn
authors.initials: C
authors.lastname: Clary
mesh_terms: D000328:Adult; D000928:Antidepressive Agents / Q000009:adverse effects / Q000627:therapeutic use*; D002648:Child; D002649:Child Abuse / Q000523:psychology*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007398:Interpersonal Relations; D008016:Life Change Events; D008297:Male; D008875:Middle Aged; D010552:Personality Assessment; D016032:Randomized Controlled Trials as Topic; D020280:Sertraline / Q000009:adverse effects / Q000627:therapeutic use*; D013313:Stress Disorders, Post-Traumatic / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D000928:Antidepressive Agents; D020280:Sertraline