title: Autophagy and neurodegeneration.
abstract: Autophagy mediates the bulk degradation of cytosolic proteins and organelles. Recent studies using neuron-specific knockout mouse models demonstrate that autophagy deficiency leads to protein aggregation and neurodegeneration, even in the absence of disease-related aggregate-prone proteins.
authors.affiliation: Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, USA.
authors.forename: Congcong
authors.initials: C
authors.lastname: He
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Klionsky
mesh_terms: D000818:Animals; D001343:Autophagy / Q000235:genetics / Q000502:physiology*; D006801:Humans; D009410:Nerve Degeneration / Q000235:genetics / Q000378:metabolism* / Q000473:pathology*; D019636:Neurodegenerative Diseases / Q000235:genetics / Q000378:metabolism* / Q000473:pathology*