title: [8-hydroxy-2'-deoxyguanosine and lipid peroxidation in patients with heart failure].
abstract: OBJECTIVE
  Heart failure is associated with increased free radical production, which leads to a state of oxidative stress. Known markers of oxidative stress include 8-hydroxy-2'-deoxyguanosine, which reflects oxidative damage to DNA, and lipid peroxidation, which can be used to quantify damage to lipid-rich structures. The aims of this study were to compare 8-hydroxy-2'-deoxyguanosine and lipid peroxidation levels in heart failure patients and healthy subjects and to assess how these levels are influenced by heart failure etiology.
  
  
  METHODS
  The study included 78 patients (57 male, age 64 [14] years) with heart failure and 12 control subjects. Patients completed a questionnaire and were graded according to the New York Heart Association classification. Doppler echocardiography was performed and blood samples were obtained. 8-hydroxy-2'-deoxyguanosine and lipid peroxidation levels were determined.
  
  
  RESULTS
  Significant differences were observed between patients and control subjects in 8-hydroxy-2'-deoxyguanosine and lipid peroxidation levels, at 0.34 (0.54) ng/mL vs 0.04 (0.07) ng/mL (P<.05), and 18 (10) microM vs 8 (3) microM (P<.01), respectively. Subsequent analysis showed that heart failure etiology had a significant effect on the levels of the two markers (P<.05), which were highest in patients with hypertensive cardiomyopathy.
  
  
  CONCLUSIONS
  Levels of 8-hydroxy-2'-deoxyguanosine and lipid peroxidation were higher in heart failure patients than in control subjects. The most significant increases were found in patients with hypertensive cardiomyopathy.
authors.affiliation: Unidad de Cardiología, Centro de Investigación Hospital La Fe. Valencia, Spain. rivera_jmi@gva.es
authors.forename: Miguel
authors.initials: M
authors.lastname: Rivera
authors.forename: Esther
authors.initials: E
authors.lastname: Roselló-Lletí
authors.forename: Fernando
authors.initials: F
authors.lastname: García de Burgos
authors.forename: Vicente
authors.initials: V
authors.lastname: Bertomeu
authors.forename: Rafael
authors.initials: R
authors.lastname: Payá
authors.forename: Raquel
authors.initials: R
authors.lastname: Cortés
authors.forename: Luís
authors.initials: L
authors.lastname: Martínez-Dolz
authors.forename: Alejandro
authors.initials: A
authors.lastname: Jordán
authors.forename: Jose L
authors.initials: JL
authors.lastname: Pérez-Boscá
authors.forename: Antonio
authors.initials: A
authors.lastname: Salvador
authors.forename: Francisco
authors.initials: F
authors.lastname: Marín
authors.forename: Francisco
authors.initials: F
authors.lastname: Sogorb
authors.forename: Ricardo
authors.initials: R
authors.lastname: Valero
authors.forename: Vicente
authors.initials: V
authors.lastname: Miró
authors.forename: Manuel
authors.initials: M
authors.lastname: Portolés
mesh_terms: D000080242:8-Hydroxy-2'-Deoxyguanosine; D016022:Case-Control Studies; D003849:Deoxyguanosine / Q000031:analogs & derivatives* / Q000097:blood; D005260:Female; D006333:Heart Failure / Q000097:blood* / Q000378:metabolism; D006801:Humans; D015227:Lipid Peroxidation; D008297:Male; D008875:Middle Aged
chemical_list: D000080242:8-Hydroxy-2'-Deoxyguanosine; D003849:Deoxyguanosine