[Susceptibility genes for the development of autoimmune thyroid disease].
Autoimmune thyroid disease (AITD) is caused by an immune response to self thyroid antigens. Twin studies and familial aggregation indicated that AITD is a complex disease with genetic factors and major histocompatibility complex is the most clearly established genetic factor. We confirmed the association of the co-receptor CTLA4 with AITD. We have identified the association of the SNP in the Fc receptor-like 3 with several autoimmune diseases, including AITD, SLE and rheumatoid arthritis, which SNP affected the level of autoantibody production. Furthermore, we have identified ZFAT as a susceptibility gene in 8q24 for AITD by whole-genome linkage analysis and further SNP-based dense mapping. The associated SNP in ZFAT affected the antisense transcript of ZFAT, which in turn affected the ZFAT expression.
Shirasawa
Senji
S
Department of Cell Biology, School of Medicine, Fukuoka University.
D015703:Antigens, CD / Q000235:genetics / Q000502:physiology; D000943:Antigens, Differentiation / Q000235:genetics / Q000502:physiology; D001327:Autoimmune Diseases / Q000235:genetics*; D060908:CTLA-4 Antigen; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006111:Graves Disease / Q000235:genetics; D006680:HLA Antigens / Q000235:genetics / Q000502:physiology; D050031:Hashimoto Disease / Q000235:genetics; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D011971:Receptors, Immunologic / Q000235:genetics / Q000502:physiology; D013959:Thyroid Diseases / Q000235:genetics*; D016335:Zinc Fingers / Q000235:genetics / Q000502:physiology
D015703:Antigens, CD; D000943:Antigens, Differentiation; D060908:CTLA-4 Antigen; C556706:CTLA4 protein, human; C457775:FCRL3 protein, human; D006680:HLA Antigens; D011971:Receptors, Immunologic