title: [Effects of vasectomy on prostatic histomorphology and cell apoptosis in rats].
abstract: OBJECTIVE
  To detect the effects of vasectomy on the growth and apoptosis of prostatic tissue cells.
  
  
  METHODS
  Forty-five SD rats were divided at random into three groups of fifteen each. Vasectomy (Vsm) model was established by ligating the bilateral vas deferens of the rats in Group A and testosterone propionate and normal saline were subcutaneously injected in those of Groups B and C, respectively. The area percentage of each part in the prostatic tissue was measured with computer-assisted image analysis system. The apoptotic rate was examined with TUNEL.
  
  
  RESULTS
  The ratio of stromal area to epithelial plus lumen area in the prostatic tissues in Groups A, B and C were (29.20 +/- 6.85), (39.77 +/- 7.58) and (48.90 +/- 6.49), respectively, and the differences were significant statistically (P all < 0.05). The apoptosis rates in Groups A, B and C were (6.39 +/- 0.84)%, (2.62 +/- 0.57)% and (4.58 +/- 0.93)%, respectively, significantly higher in Group A than in Groups B and C (P all < 0.05).
  
  
  CONCLUSIONS
  Vasectomy may induce interstitium reduction and cell apoptosis in the prostatic tissues of rats, which may help prevent benign prostatic hyperplasia.
authors.affiliation: Research Institute of Urology, Weifang Medical College, Weifang, Shandong 261042, China. sdwfgdj123@163.com
authors.forename: Dian-jun
authors.initials: DJ
authors.lastname: Gao
authors.forename: Jin-sheng
authors.initials: JS
authors.lastname: Wu
authors.forename: Lian-jun
authors.initials: LJ
authors.lastname: Pan
authors.forename: Feng
authors.initials: F
authors.lastname: Feng
mesh_terms: D000818:Animals; D017209:Apoptosis; D007091:Image Processing, Computer-Assisted; D020287:In Situ Nick-End Labeling; D008297:Male; D011467:Prostate / Q000033:anatomy & histology / Q000166:cytology*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D043343:Testosterone Propionate / Q000008:administration & dosage; D014659:Vasectomy
chemical_list: D043343:Testosterone Propionate