Role of obesity, insulin resistance, and steatosis in hepatitis C virus infection.
Hepatitis C, nonalcoholic fatty liver characterized by hepatic steatosis, and obesity inflict significant health and economic burdens on the Western world. Insulin resistance is the key player in these disease processes. Complex interplay between these conditions results in the ultimate phenotype of liver disease. This article focuses on the current understanding of host and viral interactions as well as on consequent clinical implications.
Puri
Puneet
P
Division of Gastroenterology, Hepatology and Nutrition, Department of Internal Medicine, Virginia Commonwealth University Health System, 1200 East Broad Street, Richmond, VA 23298, USA.
Sanyal
Arun J
AJ
D052436:Adipose Tissue, White / Q000378:metabolism / Q000821:virology; D005234:Fatty Liver / Q000378:metabolism / Q000821:virology*; D016174:Hepacivirus / Q000254:growth & development*; D019698:Hepatitis C, Chronic / Q000150:complications* / Q000378:metabolism / Q000821:virology; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D009765:Obesity / Q000378:metabolism / Q000821:virology*