title: Essential thrombocythemia in a dog.
abstract: A two-year old male Welsh Corgi was referred for persistent thrombocytosis and occasional seizure. Hematological findings indicated marked thrombocytosis, eosinophilia, basophilia and moderate anemia. Bone marrow examination revealed marked megakaryocytic hyperplasia with morphologic abnormality. A diagnosis of essential thrombocythemia was made and the treatment was initiated with combination chemotherapy and maintained by prednisolone and busulfan. The dog successfully achieved complete remission on 100 days after initial presentation and has been good in health without chemotherapy since then.
authors.affiliation: Sanyo Animal Medical Center, Okayama, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Mizukoshi
authors.forename: Yasuhito
authors.initials: Y
authors.lastname: Fujino
authors.forename: Kuniyoshi
authors.initials: K
authors.lastname: Yasukawa
authors.forename: Hidefumi
authors.initials: H
authors.lastname: Matumoto
authors.forename: Shingo
authors.initials: S
authors.lastname: Matsumura
authors.forename: Teppei
authors.initials: T
authors.lastname: Nagasaki
authors.forename: Koichi
authors.initials: K
authors.lastname: Ohno
authors.forename: Hajime
authors.initials: H
authors.lastname: Tsujimoto
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Shimoda
mesh_terms: D000818:Animals; D002066:Busulfan / Q000627:therapeutic use; D004283:Dog Diseases / Q000188:drug therapy / Q000473:pathology*; D004285:Dogs; D004359:Drug Therapy, Combination; D008297:Male; D011239:Prednisolone / Q000627:therapeutic use; D013920:Thrombocythemia, Essential / Q000473:pathology / Q000662:veterinary*; D016896:Treatment Outcome
chemical_list: D011239:Prednisolone; D002066:Busulfan