title: Role of hormone cofactors in the human papillomavirus-induced carcinogenesis of the uterine cervix.
abstract: If human papillomavirus (HPV) is necessary for the development of (pre)neoplastic lesions of the uterine cervix, it is not sufficient. Among the cofactors involved in the malignant transformation of cells infected by HPV, sex hormones may facilitate the cervical carcinogenesis by different mechanisms, including the induction of squamous metaplasia in the transformation zone of the cervix, interactions between steroid hormones and HPV gene expression and alterations of the local immune microenvironment.
authors.affiliation: Department of Pathology, CRCE-CBIG, B35, University of Liege, CHU Sart Tilman, 4000 Liege, Belgium. P.Delvenne@ulg.ac.be
authors.forename: Philippe
authors.initials: P
authors.lastname: Delvenne
authors.forename: Ludivine
authors.initials: L
authors.lastname: Herman
authors.forename: Natalia
authors.initials: N
authors.lastname: Kholod
authors.forename: Jean-Hubert
authors.initials: JH
authors.lastname: Caberg
authors.forename: Michaël
authors.initials: M
authors.lastname: Herfs
authors.forename: Jacques
authors.initials: J
authors.lastname: Boniver
authors.forename: Nathalie
authors.initials: N
authors.lastname: Jacobs
authors.forename: Pascale
authors.initials: P
authors.lastname: Hubert
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000276:immunology / Q000378:metabolism* / Q000473:pathology / Q000821:virology; D002472:Cell Transformation, Viral / Q000276:immunology; D002584:Cervix Uteri / Q000276:immunology / Q000378:metabolism / Q000473:pathology / Q000821:virology; D005260:Female; D015967:Gene Expression Regulation, Viral; D012739:Gonadal Steroid Hormones / Q000378:metabolism*; D006801:Humans; D008679:Metaplasia; D014412:Tumor Virus Infections / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D002583:Uterine Cervical Neoplasms / Q000276:immunology / Q000378:metabolism* / Q000473:pathology / Q000821:virology
chemical_list: D012739:Gonadal Steroid Hormones