title: Molecular design of alkylating pyrrole-imidazole polyamides with indole linker.
abstract: A series of novel DNA alkylating polyamide possessing indole linker was synthesized. The reactivities and specificities of these polyamides with double strand DNA were investigated by using high-resolution gel electrophoresis. The results revealed that the indole linker linked Py-Im polyamides have the high alkylating activities and sequence specificities comparable to vinyl linker linked Py-Im polyamides.
authors.affiliation: School of Biomedical Science, Tokyo Medical and Dental University, 2-3-10 Kanda-Surugadai, Chiyoda-ku, Tokyo 101-0062, Japan.
authors.forename: Shunta
authors.initials: S
authors.lastname: Sasaki
authors.forename: Akihiko
authors.initials: A
authors.lastname: Narita
authors.forename: Toshikazu
authors.initials: T
authors.lastname: Bando
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Sugiyama
mesh_terms: D000478:Alkylation; D007093:Imidazoles / Q000737:chemistry*; D007211:Indoles / Q000737:chemistry*; D009757:Nylons / Q000737:chemistry*; D011758:Pyrroles / Q000737:chemistry*
chemical_list: D007093:Imidazoles; D007211:Indoles; D009757:Nylons; D011758:Pyrroles; C029899:imidazole; C030374:indole