Relationship between autoimmune phenomena and disease stage and therapy in B-cell chronic lymphocytic leukemia.
The aim of this multicenter GIMEMA study was to correlate autoimmune complications (AIC) in B-cell chronic lymphocytic leukemia (B-CLL) with stage and therapy. Autoimmune hemolytic anemia (129/194 cases) and autoimmune thrombocytopenia (35/194 cases) were typically present in advanced and multi-treated disease. Age over the median, stage C and first and second line therapy were identified as independent risk factors by multivariate analysis. In contrast, non-hematologic AIC (30/194 cases) and the presence of serological markers of autoimmunity were mostly observed in early B-CLL, suggesting different pathogenic mechanisms underlying hematologic and non-hematologic autoimmune phenomena in B-CLL.
Barcellini
Wilma
W
Department of Haematology, Padiglione Granelli, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Via F. Sforza 35 20122 Milan, Italy. wbarcel@policlinico.mi.it
Capalbo
Silvana
S
Agostinelli
Rosa Maria
RM
Mauro
Francesca Romana
FR
Ambrosetti
Achille
A
Calori
Rossella
R
Cortelezzi
Agostino
A
Laurenti
Luca
L
Pogliani
Enrico Maria
EM
Pedotti
Paola
P
Liso
Vincenzo
V
Girelli
Gabriella
G
Mandelli
Franco
F
Zanella
Alberto
A
D000368:Aged; D000369:Aged, 80 and over; D000744:Anemia, Hemolytic, Autoimmune / Q000276:immunology*; D000970:Antineoplastic Agents / Q000627:therapeutic use; D005260:Female; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000276:immunology* / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000276:immunology*; D012189:Retrospective Studies
D000970:Antineoplastic Agents