title: The effect of zaltoprofen on physiotherapy for limited shoulder movement in breast cancer patients: a single-blinded before-after trial.
abstract: OBJECTIVE
  To determine the efficacy of oral administration of zaltoprofen on shoulder range of motion (ROM) exercises for breast cancer patients after surgery.
  
  
  METHODS
  Single-blind, before-after trial.
  
  
  METHODS
  Rehabilitation facility in a Japanese university hospital.
  
  
  METHODS
  Forty breast cancer patients (age range, 37-72y) with limited shoulder movement after surgery.
  
  
  METHODS
  Single session of physiotherapy (PT) with or without oral administration of zaltoprofen.
  
  
  METHODS
  Active shoulder ROM in flexion, abduction, and external rotation, as well as subjective pain score during shoulder movements.
  
  
  RESULTS
  Active shoulder movements after ingesting a zaltoprofen tablet significantly improved in flexion, abduction (P<.001), and external rotation (P<.005). PT treatment improved flexion and abduction ROM in both the zaltoprofen and control groups and led to significantly larger flexion and abduction movements in the zaltoprofen group than in the control group (P<.01). There were no differences in pain scores between groups, but 2 patients who did not receive zaltoprofen complained of increased pain just after ROM exercises.
  
  
  CONCLUSIONS
  Zaltoprofen taken orally before ROM exercises for painful shoulder after breast cancer surgery may enhance the effects of PT.
authors.affiliation: Department of Rehabilitation Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan. khase@sc.itc.keio.ac.jp
authors.forename: Kimitaka
authors.initials: K
authors.lastname: Hase
authors.forename: Michiyo
authors.initials: M
authors.lastname: Kamisako
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Fujiwara
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Tsuji
authors.forename: Meigen
authors.initials: M
authors.lastname: Liu
mesh_terms: D000328:Adult; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D001578:Benzopyrans / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000503:physiopathology / Q000601:surgery; D005260:Female; D006801:Humans; D008875:Middle Aged; D009068:Movement / Q000502:physiology; D010147:Pain Measurement; D026741:Physical Therapy Modalities; D011183:Postoperative Complications / Q000503:physiopathology; D011422:Propionates / Q000627:therapeutic use*; D016059:Range of Motion, Articular / Q000502:physiology*; D012785:Shoulder Joint / Q000503:physiopathology*; D020069:Shoulder Pain / Q000188:drug therapy* / Q000503:physiopathology; D016037:Single-Blind Method
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D001578:Benzopyrans; D011422:Propionates; C043940:pyranoprofen