title: 2'-Deoxy-4'-C-ethynyl-2-fluoroadenosine: a nucleoside reverse transcriptase inhibitor with highly potent activity against all HIV-1 strains, favorable toxic profiles and stability in plasma.
abstract: A working hypothesis to solve the critical problems of existing HAART was proposed. The study based on the hypothesis proved the validity of the hypothesis and resulted in the development of 2'-deoxy-4'-C-ethynyl-2-fluoro-adenosine (4'Ed2FA), a nucleoside reverse transcriptase inhibitor (NRTI) with highly potent activity against all HIV-1 strains, very favourable toxic profiles, and stability in plasma.
authors.affiliation: Yokohama College of Pharmacy, Yokohama, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ohrui
authors.forename: Satoru
authors.initials: S
authors.lastname: Kohgo
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Hayakawa
authors.forename: Eiichi
authors.initials: E
authors.lastname: Kodama
authors.forename: Masao
authors.initials: M
authors.lastname: Matsuoka
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Nakata
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Mitsuya
mesh_terms: D000818:Animals; D019380:Anti-HIV Agents / Q000097:blood / Q000494:pharmacology* / Q000633:toxicity; D003839:Deoxyadenosines / Q000097:blood / Q000494:pharmacology* / Q000633:toxicity; D004355:Drug Stability; D015497:HIV-1 / Q000187:drug effects*; D051379:Mice; D018894:Reverse Transcriptase Inhibitors / Q000097:blood / Q000494:pharmacology* / Q000633:toxicity
chemical_list: C520539:2'-deoxy-4'-C-ethynyl-2-fluoroadenosine; D019380:Anti-HIV Agents; D003839:Deoxyadenosines; D018894:Reverse Transcriptase Inhibitors