Antiamnesic effect of combined treatment with galantamine and estradiol in middle-aged ovariectomized female rats.
The effect of chronic combined treatment with galantamine and 17beta-estradiol on passive avoidance retention was studied in middle-aged ovariectomized female rats (15 months) with scopolamine-induced amnesia. Combined treatment with galantamine and estradiol completely restored retrieval of memory traces in middle-aged ovariectomized female rats.
Losev
N A
NA
S. V. Anichkov Department of Neuropharmacology, Institute of Experimental Medicine, Russian Academy of Medical Sciences, St. Petersburg.
Fedotova
Yu O
YO
Sapronov
N S
NS
D000647:Amnesia / Q000188:drug therapy*; D000818:Animals; D004958:Estradiol / Q000378:metabolism / Q000494:pharmacology*; D004967:Estrogens / Q000172:deficiency; D005260:Female; D005702:Galantamine / Q000494:pharmacology*; D008568:Memory / Q000187:drug effects*; D018727:Muscarinic Antagonists / Q000494:pharmacology; D010052:Ovariectomy; D010053:Ovary / Q000502:physiology*; D051381:Rats; D012601:Scopolamine / Q000494:pharmacology; D013997:Time Factors
D004967:Estrogens; D018727:Muscarinic Antagonists; D005702:Galantamine; D004958:Estradiol; D012601:Scopolamine