Weight-bearing, aerobic exercise increases markers of bone formation during short-term weight loss in overweight and obese men and women.
We investigated the impact of weight-bearing, aerobic exercise- and diet-induced weight loss on markers of bone turnover during a larger study of changes in metabolic fitness during short-term weight reduction using a repeated-measures, within-subject experimental design. Subjects (N = 19) underwent 6 weeks of energy restriction (reduced by approximately 3140 kJ/d) and aerobic exercise ( approximately 1675 kJ/d, walking or jogging at 60% maximum oxygen consumption) to induce a 5% reduction in body weight. Bone turnover markers and hormones were measured in serum collected at baseline and after 6 weeks of weight loss. Despite a 5% reduction in body weight at week 6, markers of bone formation, osteocalcin, and bone alkaline phosphatase, were significantly increased, and resorption markers, C-terminal cross-links of type I collagen and soluble receptor activator of nuclear factor kappaB ligand, were unchanged after 6 weeks of energy restriction and exercise. The concentration of leptin was significantly reduced after weight loss, but insulin-like growth factor I (IGF-I) and cortisol levels were unaffected. In conclusion, weight-bearing, aerobic exercise training may favorably affect the balance between bone resorption and formation during weight loss.
Hinton
Pamela S
PS
Department of Nutritional Sciences, University of Missouri-Columbia, Columbia, MO 65211, USA. hintonp@missouri.edu
Rector
R Scott
RS
Thomas
Tom R
TR
D000293:Adolescent; D000328:Adult; D000469:Alkaline Phosphatase / Q000097:blood; D001862:Bone Resorption / Q000517:prevention & control; D015444:Exercise; D005260:Female; D006801:Humans; D020738:Leptin / Q000097:blood; D008297:Male; D009765:Obesity / Q000378:metabolism*; D015675:Osteocalcin / Q000097:blood; D010012:Osteogenesis; D050177:Overweight; D015431:Weight Loss; D016474:Weight-Bearing
D020738:Leptin; D015675:Osteocalcin; D000469:Alkaline Phosphatase