Clinical features of colorectal cancer before emergency presentation: a population-based case-control study.
OBJECTIVE
To identify the clinical features of colorectal cancer presenting as a surgical emergency.


METHODS
Population-based case-control study.


METHODS
All general practices in Exeter Primary Care Trust, Devon, UK. Participants. 349 patients with colorectal cancer, 62 of these having an emergency presentation. Five randomly selected controls matched by age, sex and general practice for each case.


METHODS
The entire primary care record, from 24 months to 30 days before diagnosis, was coded using the International Classification of Primary Care-2.


METHODS
Symptom reporting by patients with emergency presentation of colorectal cancer compared with matched controls and non-emergency presentations.


RESULTS
Eight features of colorectal cancer were associated with the 62 emergency presentations of colorectal cancer. 39 (63%) of patients had reported at least one symptom to their doctors a minimum of 30 days before the diagnosis. In multivariable analysis, three features remained independently associated with cancer: abdominal pain, odds ratio 6.2 (95% CI 2.8-14), P<0.001; loss of weight 3.4 (1.3-8.5), P=0.01; and diarrhoea 3.4 (1.2-5.7), P=0.02. When emergency presentations were compared with elective cases, abdominal pain was more common [interaction odds ratio 2.3 (1.6-3.3); P=0.047] and rectal bleeding less common [0.30 (0.08, 1.0); P=0.040].


CONCLUSIONS
The majority of patients destined to have an emergency presentation of colorectal cancer have reported symptoms of their cancer to their doctor well before the emergency. Some emergency presentations should therefore be preventable.
Cleary
Jonathan
J
Academic Unit of Primary Health Care, Department of Community Based Medicine, University of Bristol The Grange, 1 Woodland Road, Bristol BS8 1AU, UK.
Peters
Tim J
TJ
Sharp
Deborah
D
Hamilton
William
W
D015746:Abdominal Pain / Q000209:etiology; D000328:Adult; D000368:Aged; D015179:Colorectal Neoplasms / Q000150:complications / Q000175:diagnosis*; D003967:Diarrhea / Q000209:etiology; D042241:Early Diagnosis; D004630:Emergencies / Q000145:classification; D004739:England; D005194:Family Practice / Q000592:standards* / Q000706:statistics & numerical data; D006801:Humans; D007415:Intestinal Obstruction / Q000209:etiology; D016015:Logistic Models; D008875:Middle Aged; D015999:Multivariate Analysis; D010342:Patient Acceptance of Health Care; D011320:Primary Health Care / Q000592:standards* / Q000706:statistics & numerical data; D013997:Time Factors; D015431:Weight Loss