Homocysteine toxicity in organotypic cultures of rat retina.
Effects of homocysteine in toxic concentrations on retinal neurons were studied in vitro. In organotypic roller cultures of postnatal (8-12-day-old) and adult rat retina homocysteine caused multiple damage to neurons in the outer nuclear layer, in deep compartments of the inner nuclear layer, and ganglion cell layer.
Viktorov
I V
IV
Laboratory of Experimental Neurocytology, Institute of Brain Research, Russian Academy of Medical Sciences, Moscow. ivic@4unet.ru
Aleksandrova
O P
OP
Alekseeva
N Yu
NY
D000818:Animals; D000831:Animals, Newborn; D002467:Cell Nucleus / Q000378:metabolism; D005724:Ganglia / Q000378:metabolism; D006710:Homocysteine / Q000737:chemistry / Q000633:toxicity*; D009474:Neurons / Q000378:metabolism; D009924:Organ Culture Techniques / Q000379:methods; D051381:Rats; D012160:Retina / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology*
D006710:Homocysteine