[Expression of BDNF and trk B in the cochleas of the aged rats].
OBJECTIVE
To explore the correlation between the expression of brain derived neurotrophic factor (BDNF) and presbycusis in the cochleae of the aged rats.


METHODS
The mRNA expression of BDNF and presbycusis in the cochleas of the aged rats was quantitated by real time PCR.


RESULTS
The expression of BDNF in the cochleas of the aged rats with presbycusis was obviously less than that in the control group. And the difference was statistically significant.


CONCLUSIONS
The expression of BDNF is closely correlated to presbycusis in the aged rats.
Li
Yuru
Y
Department of Otolaryngology, First Hospital of Harbin Medical University, Harbin 150001, China.
Liu
Delong
D
Zhang
Yuanyuan
Y
Wang
Ping
P
Du
Baodong
B
D000375:Aging; D000818:Animals; D019208:Brain-Derived Neurotrophic Factor / Q000378:metabolism*; D003051:Cochlea / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D020813:Receptor, trkB / Q000378:metabolism*
D019208:Brain-Derived Neurotrophic Factor; D020813:Receptor, trkB