title: Role of respiratory syncytial virus in acute otitis media: implications for vaccine development.
abstract: We summarize herein the results of various virologic studies of acute otitis media (AOM) conducted at our site over a 10-year period. Among 566 children with AOM, respiratory syncytial virus (RSV) was the most common virus identified in either middle ear fluid or nasal wash; it was found in 16% of all children and 38% of virus-positive children. Seventy-one percent of the children with RSV were 1 year of age or older, which was significantly older than all other viruses combined (P=0.045). RSV infection was associated with the common bacterial pathogens causing AOM. Past efforts to develop vaccines for RSV have emphasized prevention of lower respiratory tract infection in infants, which is a more serious problem but less common than AOM. Our results suggest that RSV vaccines that work only against infection in older children may have value in preventing AOM, the most common pediatric disease.
authors.affiliation: Departments of Pediatrics, University of Texas Medical Branch, Galveston, TX 77555-0371, United States. jpatel@utmb.edu
authors.forename: Janak A
authors.initials: JA
authors.lastname: Patel
authors.forename: Dang T
authors.initials: DT
authors.lastname: Nguyen
authors.forename: Krystal
authors.initials: K
authors.lastname: Revai
authors.forename: Tasnee
authors.initials: T
authors.lastname: Chonmaitree
mesh_terms: D000208:Acute Disease; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D010033:Otitis Media / Q000175:diagnosis / Q000453:epidemiology / Q000517:prevention & control / Q000821:virology; D015995:Prevalence; D018357:Respiratory Syncytial Virus Infections / Q000453:epidemiology* / Q000517:prevention & control* / Q000821:virology; D022261:Respiratory Syncytial Virus Vaccines; D018113:Respiratory Syncytial Virus, Human / Q000276:immunology* / Q000302:isolation & purification
chemical_list: D022261:Respiratory Syncytial Virus Vaccines