title: Treatment with flunitrazepam of continuous spikes and waves during slow wave sleep (CSWS) in children.
abstract: We describe our treatment of two boys with continuous spikes and waves during slow wave sleep (CSWS). One of the boys was suffering from non-convulsive status epilepticus and the other from conscious disturbance with automatism. Their ictal EEG readings showed continuous diffuse spike and wave complexes, which were considered to show electrical status. The boys were diagnosed as having CSWS, and were later diagnosed with Landau-Kleffner syndrome (LKS). EEG readings returned to normal on intravenous injection of flunitazepam (FZP) at a dose of 0.02 mg/kg, suggesting that FZP is an effective treatment for CSWS.
authors.affiliation: Department of Pediatrics, Nippon Medical School Tama Nagayama Hospital, 1-7-1 Nagayama Tama, Tokyo 206-8512, Japan. kawakami@nms.ac.jp
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Kawakami
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Matsumoto
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Hashimoto
authors.forename: Kentaro
authors.initials: K
authors.lastname: Kuwabara
authors.forename: Kiyotaka
authors.initials: K
authors.lastname: Hirata
authors.forename: Takehisa
authors.initials: T
authors.lastname: Fujita
authors.forename: Osamu
authors.initials: O
authors.lastname: Fujino
mesh_terms: D000927:Anticonvulsants / Q000627:therapeutic use*; D002648:Child; D004569:Electroencephalography / Q000187:drug effects*; D004827:Epilepsy / Q000473:pathology*; D005445:Flunitrazepam / Q000627:therapeutic use*; D006801:Humans; D018887:Landau-Kleffner Syndrome / Q000175:diagnosis* / Q000188:drug therapy; D008297:Male; D012890:Sleep / Q000187:drug effects* / Q000502:physiology; D013226:Status Epilepticus / Q000188:drug therapy / Q000503:physiopathology
chemical_list: D000927:Anticonvulsants; D005445:Flunitrazepam