title: Large common fragile site genes and cancer.
abstract: The common fragile sites are large regions of genomic instability that are found in all individuals and are hot spots for chromosomal rearrangements and deletions. A number of the common fragile sites have been found to span genes that are encoded by very large genomic regions. Two of these genes, FHIT and WWOX, have already been demonstrated to function as tumor suppressors. In this review we will discuss the large common fragile site genes that have been identified to date, and the role that these genes appear to play both in cellular responses to stress and in the development of cancer.
authors.affiliation: Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, 200 First Street, S.W., Rochester, MN 55905, United States. smith.david@mayo.edu
authors.forename: David I
authors.initials: DI
authors.lastname: Smith
authors.forename: Sarah
authors.initials: S
authors.lastname: McAvoy
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhu
authors.forename: Damon S
authors.initials: DS
authors.lastname: Perez
mesh_terms: D017766:Acid Anhydride Hydrolases / Q000235:genetics; D019457:Chromosome Breakage; D043283:Chromosome Fragile Sites; D002873:Chromosome Fragility; D052138:Genes, Neoplasm; D016147:Genes, Tumor Suppressor; D020022:Genetic Predisposition to Disease; D016678:Genome; D015894:Genome, Human; D042822:Genomic Instability; D006801:Humans; D008957:Models, Genetic; D009363:Neoplasm Proteins / Q000235:genetics; D009369:Neoplasms / Q000235:genetics*; D010088:Oxidoreductases / Q000235:genetics; D025521:Tumor Suppressor Proteins; D000074584:WW Domain-Containing Oxidoreductase; D000099170:Bis(5'-adenosyl)triphosphatase
chemical_list: D017766:Acid Anhydride Hydrolases; D009363:Neoplasm Proteins; D010088:Oxidoreductases; D025521:Tumor Suppressor Proteins; D000074584:WW Domain-Containing Oxidoreductase; D000099170:Bis(5'-adenosyl)triphosphatase; C486071:WWOX protein, human