title: Targeting translation in hypoxic tumors.
abstract: Recent insight into how mammalian cells adapt their translational machinery to hypoxic conditions raises the possibility of targeting components of the regulatory networks involved to selectively inhibit metabolically compromised tumor cells and possibly manipulate a broad range of other physiological processes.
authors.affiliation: Skirball Institute of Biomolecular Medicine and the Department of Medicine, New York University School of Medicine, New York, New York 10016, USA. ron@saturn.med.nyu.edu
authors.forename: David
authors.initials: D
authors.lastname: Ron
authors.forename: Alan G
authors.initials: AG
authors.lastname: Hinnebusch
mesh_terms: D000818:Animals; D015687:Cell Hypoxia / Q000235:genetics*; D039561:Eukaryotic Initiation Factor-4E / Q000378:metabolism; D015972:Gene Expression Regulation, Neoplastic; D006706:Homeostasis; D006801:Humans; D008322:Mammals; D008954:Models, Biological; D009363:Neoplasm Proteins / Q000235:genetics; D009369:Neoplasms / Q000098:blood supply / Q000235:genetics* / Q000473:pathology*; D010101:Oxygen Consumption; D014176:Protein Biosynthesis
chemical_list: D039561:Eukaryotic Initiation Factor-4E; D009363:Neoplasm Proteins