Discovery of (Z)-2-phenyl-3-(1H-pyrrol-2-yl)acrylonitrile derivatives active against Haemonchus contortus and Ctenocephalides felis (cat flea).
A series of 2-phenyl-3-(1H-pyrrol-2-yl)acrylonitrile derivatives were synthesized and evaluated for in vitro activity against the endoparasite Haemonchus contortus and the ectoparasite Ctenocephalides felis. Some compounds had significant in vitro activity against these parasites.
Ali
Abdelselam
A
CSIRO, Molecular and Health Technologies, Bayview Avenue, Clayton, Vic. 3168, Australia.
Bliese
Marianne
M
Rasmussen
Jo-Anne M
JA
Sargent
Roger M
RM
Saubern
Simon
S
Sawutz
David G
DG
Wilkie
John S
JS
Winkler
David A
DA
Winzenberg
Kevin N
KN
Woodgate
Ruth C J
RC
D000181:Acrylonitrile / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D000818:Animals; D000969:Antinematodal Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D000977:Antiparasitic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002415:Cats; D006189:Haemonchus / Q000187:drug effects*; D007306:Insecticides / Q000138:chemical synthesis* / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D005423:Siphonaptera / Q000502:physiology*; D013329:Structure-Activity Relationship
C518728:(Z)-2-phenyl-3-(1H-pyrrol-2-yl)acrylonitrile; D000969:Antinematodal Agents; D000977:Antiparasitic Agents; D007306:Insecticides; D000181:Acrylonitrile