Revenge of the NRD: preferential degradation of nonfunctional eukaryotic rRNA.
Eukaryotic cells have several quality control systems that monitor the proper processing of RNAs during RNA biogenesis or the function of cytoplasmic mRNAs. A recent study in Molecular Cell by LaRiviere et al. (2006) shows that after production, mature rRNA is also subject to quality control and nonfunctional ribosomes are targeted for destruction by a novel ribosome surveillance mechanism.
Doma
Meenakshi K
MK
Howard Hughes Medical Institute, Department of Molecular and Cellular Biology, University of Arizona, Tucson, Arizona 85721, USA.
Parker
Roy
R
D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism; D005057:Eukaryotic Cells; D006801:Humans; D012322:RNA Precursors / Q000378:metabolism*; D012323:RNA Processing, Post-Transcriptional; D012335:RNA, Ribosomal / Q000378:metabolism*
D012322:RNA Precursors; D012335:RNA, Ribosomal