Contractile responses of rabbit bladder neck to adrenaline, acetylcholine and papaverine after doxazosin treatment.
It has been demonstrated that long-term administration of doxazosin, an alpha 1 adrenoceptor antagonist, causes an up-regulation in the expression of alpha 1 adrenoceptor subtype mRNAs in the rat genitourinary tract. The aim of this study is to determine whether this up-regulation does have any effect on contractile response of rabbit bladder neck to adrenaline, acethylcholine and papaverin after long-term doxazosin treatment. Fourteen rabbits, treated with doxazosin 3 mg/kg/day p.o for 6 months, and were fed with a diet of standard laboratory rabbit chow (100 g/kg/day). Ten rabbits received the same amount of regular chow but no drug. Contractile responses of rabbit bladder neck to adrenaline acethylcholine and papaverine were measured.
Eroglu
Muzaffer
M
School of Medicine, Clinics of Urology, Abant Izzet Baysal University, Bolu 14280, Turkey.
Sezgin
Aysun
A
Semercioz
Atilla
A
Metin
Ahmed
A
Kandirali
Engin
E
Ali Onur
M
M
D000109:Acetylcholine / Q000494:pharmacology*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D017292:Doxazosin / Q000494:pharmacology*; D004837:Epinephrine / Q000494:pharmacology*; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D009126:Muscle Relaxation / Q000187:drug effects; D010208:Papaverine / Q000494:pharmacology*; D011817:Rabbits; D051381:Rats; D001743:Urinary Bladder / Q000187:drug effects*
D010208:Papaverine; D000109:Acetylcholine; D017292:Doxazosin; D004837:Epinephrine