title: [Clinical study on pulmonary complications after allogeneic peripheral blood stem cell transplantation].
abstract: OBJECTIVE
  To explore the incidence, pathogenesis, risk factors and effective treatment of pulmonary complications after allogeneic peripheral blood stem cell transplantation (allo-PBSCT).
  
  
  METHODS
  Pulmonary complications in 70 patients received allo-PBSCT were analyzed.
  
  
  RESULTS
  Thirty one episodes were observed in 26 patients. Among them episodes were infectious complications, including bacteria pneumonia, pulmonary fungus disease, CMV interstitial pneumonia and tuberculosis, some cases were caused by two pathogens, and 11 episodes were noninfectious complications, including late-onset noninfectious pulmonary complications (LONIPCs) (n=9), pulmonary edema (n=1) and interstitial pneumonia (n=1). The overall mortality was 12.9%. Graft-versus-host disease (GVHD) prophylaxis without MTX, severe acute GVHD and extensive chronic GVHD were high risk factors for pulmonary complications and advanced disease at transplantation, extensive chronic GVHD were significantly associated with the incidence of LONIPCs.
  
  
  CONCLUSIONS
  Pulmonary disease is the main complication occurred in patients undergoing allo-PBSCT. It is of greatly importance to treat pathogens specifically and diagnose LONIPCs in its early stage.
authors.affiliation: Department of Hematology, PLA General Hospital, Beijing 100853, China.
authors.forename: Yi-zhuo
authors.initials: YZ
authors.lastname: Zhang
authors.forename: Wan-ming
authors.initials: WM
authors.lastname: Da
authors.forename: Bo-Long
authors.initials: BL
authors.lastname: Zhang
authors.forename: Chun-Ji
authors.initials: CJ
authors.lastname: Gao
authors.forename: Xiao-pin
authors.initials: XP
authors.lastname: Han
authors.forename: Wen-rong
authors.initials: WR
authors.lastname: Huang
authors.forename: Yu
authors.initials: Y
authors.lastname: Jing
authors.forename: Hong-hua
authors.initials: HH
authors.lastname: Li
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhao
authors.forename: Jian
authors.initials: J
authors.lastname: Bo
authors.forename: Shu-hong
authors.initials: SH
authors.lastname: Wang
authors.forename: Hai-yan
authors.initials: HY
authors.lastname: Zhu
authors.forename: Hai-jie
authors.initials: HJ
authors.lastname: Jin
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D006086:Graft vs Host Disease / Q000517:prevention & control; D006402:Hematologic Diseases / Q000601:surgery; D006801:Humans; D008171:Lung Diseases / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D036102:Peripheral Blood Stem Cell Transplantation / Q000009:adverse effects*