title: The effect of administering erythropoiesis-stimulating proteins in patients with chronic heart failure: results from a retrospective study.
abstract: Anemia is prevalent in patients with chronic heart failure and is associated with worse symptoms and poor prognosis. The authors reviewed the charts of all patients (N=467) treated at Texas Heart Institute from January 2000 to October 2003, during which time a clinical protocol offered treatment with erythropoiesis-stimulating proteins. Post-treatment, the authors observed a significant increase in mean +/- SD hemoglobin, from 9.9+/-1.1 g/dL to 11.7+/-1.5 g/dL (P<.0001), improvement of renal function (a decrease in mean levels of creatinine and blood urea nitrogen), and fewer hospital admissions (1.0+/-1.4 vs 1.8+/-1.6; P=.0003) without an increase in adverse clinical events, compared with pretreatment and compared with an untreated control group. These results suggest a potential benefit of anemia treatment with recombinant erythropoiesis-stimulating proteins in patients with chronic heart failure.
authors.affiliation: Department of Cardiopulmonary Transplantation, Texas Heart Institute at St Luke's Episcopal Hospital, Houston, TX 77225-0345, USA.
authors.forename: Reynolds M
authors.initials: RM
authors.lastname: Delgado
authors.forename: Rajko
authors.initials: R
authors.lastname: Radovancevic
authors.forename: Charles C
authors.initials: CC
authors.lastname: van Rossem
authors.forename: Sebastiaan J M
authors.initials: SJ
authors.lastname: Gaemers
authors.forename: Stratego
authors.initials: S
authors.lastname: Castanes
authors.forename: Stephen C
authors.initials: SC
authors.lastname: Adams
authors.forename: Arthur W
authors.initials: AW
authors.lastname: Bracey
authors.forename: Branislav
authors.initials: B
authors.lastname: Radovancevic
mesh_terms: D000368:Aged; D000740:Anemia / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D004921:Erythropoietin / Q000627:therapeutic use*; D005260:Female; D006333:Heart Failure / Q000097:blood / Q000150:complications* / Q000188:drug therapy; D006397:Hematinics; D006454:Hemoglobins / Q000032:analysis; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood; D011994:Recombinant Proteins; D012189:Retrospective Studies
chemical_list: D006397:Hematinics; D006454:Hemoglobins; D011994:Recombinant Proteins; D004921:Erythropoietin; D020097:Natriuretic Peptide, Brain