2'-Deoxy-4'-C-ethynyl-2-fluoroadenosine: a nucleoside reverse transcriptase inhibitor with highly potent activity against all HIV-1 strains, favorable toxic profiles and stability in plasma.
A working hypothesis to solve the critical problems of existing HAART was proposed. The study based on the hypothesis proved the validity of the hypothesis and resulted in the development of 2'-deoxy-4'-C-ethynyl-2-fluoro-adenosine (4'Ed2FA), a nucleoside reverse transcriptase inhibitor (NRTI) with highly potent activity against all HIV-1 strains, very favourable toxic profiles, and stability in plasma.
Ohrui
Hiroshi
H
Yokohama College of Pharmacy, Yokohama, Japan.
Kohgo
Satoru
S
Hayakawa
Hiroyuki
H
Kodama
Eiichi
E
Matsuoka
Masao
M
Nakata
Tomohiro
T
Mitsuya
Hiroyuki
H
D000818:Animals; D019380:Anti-HIV Agents / Q000097:blood / Q000494:pharmacology* / Q000633:toxicity; D003839:Deoxyadenosines / Q000097:blood / Q000494:pharmacology* / Q000633:toxicity; D004355:Drug Stability; D015497:HIV-1 / Q000187:drug effects*; D051379:Mice; D018894:Reverse Transcriptase Inhibitors / Q000097:blood / Q000494:pharmacology* / Q000633:toxicity
C520539:2'-deoxy-4'-C-ethynyl-2-fluoroadenosine; D019380:Anti-HIV Agents; D003839:Deoxyadenosines; D018894:Reverse Transcriptase Inhibitors