3-O-beta-D-glucosyl-(1-->6)-beta-D-glucosyl-kaempferol isolated from Sauropus androgenus reduces body weight gain in Wistar rats.
The young sticks and leaves of Sauropus androgynus (SA) that had been used as a health food for body weight reduction, led to an outbreak of obliterative bronchiolitis in Taiwan. This study tested the toxicity and anti-obesity features of the SA-isolated compound, 3-O-beta-D-glucosyl-(1-->6)-beta-D-glucosyl-kaempferol (GGK), on male Wistar rats receiving 6 or 60 mg/kg of GGK orally as well as partial purified EtOAc and n-BuOH fractions of SA extract daily for 28 d. Sixty milligrams per kilogram GGK treatment significantly reduced food intake in rats by 15% (p<0.05). The reduced food intake corresponded to decreases in body weight in the high or low dose GGK groups, as compared to the control groups. The serum levels of free triglyceride significantly decreased in GGK-treated rats. GGK treatment led to succesive reductions in daily food intake and body weight without obvious histopathological changes in Wistar rats. Thus, GGK may be potentially to be developed as a safe and novel compound for anti-obesity treatment.
Yu
Shih-Fing
SF
Institute of Pharmaceutical Sciences, College of Medicine, National Taiwan University, and Department of Forensic Medicine, National Taiwan University Hospital, Taipei, Taiwan.
Shun
Chia-Tung
CT
Chen
Tzer-Ming
TM
Chen
Yen-Hui
YH
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004187:Disaccharides / Q000302:isolation & purification* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D019665:Euphorbiaceae / Q000737:chemistry*; D044949:Kaempferols / Q000302:isolation & purification* / Q000494:pharmacology; D008099:Liver / Q000473:pathology; D008168:Lung / Q000473:pathology; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D015430:Weight Gain / Q000187:drug effects*
C516944:3-O-glucosyl-1-6-glucosylkaempferol; D004187:Disaccharides; D044949:Kaempferols