Lipoprotein-associated phospholipase A2 concentrations in plasma are associated with the extent of coronary artery disease and correlate to adipose tissue levels of marine n-3 fatty acids.
Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) is an emerging risk factor for cardiovascular disease. In the present study, plasma levels of Lp-PLA(2) were measured in patients (n=301) admitted to elective coronary angiography because of suspected coronary artery disease (CAD). In a multiple linear regression analysis, the degree of CAD (0-, 1-, 2- or 3-vessel disease) and plasma LDL cholesterol significantly correlated to Lp-PLA(2) levels. Also the content of the marine n-3 fatty acid, eicosapentaenoic acid (EPA) in adipose tissue, a measure of long-term intake of seafood independently and inversely (r=-0.18, p<0.01) correlated with plasma levels of Lp-PLA(2). The results support the view that Lp-PLA(2) may relate to CAD and that intake of marine n-3 fatty acids might reduce plasma Lp-PLA(2) suggesting another mechanism by which n-3 fatty acids could reduce the risk of cardiovascular disease.
Schmidt
Erik Berg
EB
Department of Cardiology and Center for Cardiovascular Research, Aalborg Hospital, Århus University Hospitals, Sdr. Skovvej 15, 9100 Aalborg, Denmark. Electronic address: ebs@dadlnet.dk.
Koenig
Wolfgang
W
Department of Internal Medicine II-Cardiology, University of Ulm Medical Center, Ulm, Germany.
Khuseyinova
Natalie
N
Department of Internal Medicine II-Cardiology, University of Ulm Medical Center, Ulm, Germany.
Christensen
Jeppe Hagstrup
JH
Department of Nephrology, Aalborg Hospital, Århus University Hospitals, Denmark.
D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase / Q000097:blood*; D000273:Adipose Tissue / Q000737:chemistry*; D000368:Aged; D003324:Coronary Artery Disease / Q000097:blood / Q000503:physiopathology*; D003718:Denmark; D015525:Fatty Acids, Omega-3 / Q000032:analysis*; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D017747:Seafood
D015525:Fatty Acids, Omega-3; D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase