title: Risk factors for local tumor recurrence after segmental transarterial chemoembolization for hepatocellular carcinoma: the importance of tumor located in the segmental border zone.
abstract: OBJECTIVE
  We wanted to evaluate whether tumors located in a segmental border zone are predisposed to local recurrence after performing segmental transarterial chemoembolization for hepatocellular carcinoma.
  
  
  METHODS
  Seventy-three hepatocellular carcinoma nodules were retrospectively analyzed for local tumor recurrence after performing segmental transarterial chemoembolization by using follow-up CT studies (median follow-up period: 20 months, range: 4-77 months). The tumors were divided into two groups according to whether the lesions were located at the segmental border zone (Group I) or not (Group II). Comparison of the tumor characteristics and chemoembolization methods between the two groups was performed using the chi-square test. The local recurrence rates were compared by Kaplan-Meyer method and analyzed with the log rank test.
  
  
  RESULTS
  Local tumor recurrence occurred for 25 hepatocellular carcinoma nodules (42.9%). The follow-up periods, tumor characteristics and chemoembolization methods between Groups l and ll were comparable. The local recurrence rate was 64.0% (16/25) in Group I and 18.8% (9/48) in Group II. The difference was statistically significant on the univariate and multivariate analyses (p = 0.000 for both).
  
  
  CONCLUSIONS
  Tumor location in a segmental border zone was a significant risk factor for local tumor recurrence after performing segmental transarterial chemoembolization for hepatocellular carcinoma.
authors.affiliation: Department of Radiology, Seoul Veterans Hospital, Gangdong-Gu, Seoul, Korea. yunkucho2004@yahoo.co.kr
authors.forename: Yun Ku
authors.initials: YK
authors.lastname: Cho
authors.forename: Jin Wook
authors.initials: JW
authors.lastname: Chung
authors.forename: Yong-Sik
authors.initials: YS
authors.lastname: Ahn
authors.forename: Yoon-Ok
authors.initials: YO
authors.lastname: Park
authors.forename: Jae Kyun
authors.initials: JK
authors.lastname: Kim
authors.forename: Jong-Hoon
authors.initials: JH
authors.lastname: Byun
mesh_terms: D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000473:pathology* / Q000628:therapy*; D016461:Chemoembolization, Therapeutic; D016009:Chi-Square Distribution; D004317:Doxorubicin / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007459:Iodized Oil / Q000008:administration & dosage; D008113:Liver Neoplasms / Q000473:pathology* / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D007459:Iodized Oil; D004317:Doxorubicin