title: Constitutional complex chromosomal rearrangements in azoospermic men--case report and literature review.
abstract: Complex chromosomal rearrangements are very rare and may lead to spermatogenic defect. We report on an infertile man with complex constitutional chromosomal rearrangements. The chromosomal breakpoints were located at 9p22, 13q22, and 21p11. This is the seventh case, to our knowledge, of complex chromosome rearrangements in a man presenting with a spermatogenic defect. The spermatogenic defect may be ascribed to disruption of sterile genes during chromosomal breakage or abnormal meiotic segregation of the rearranged chromosomes.
authors.affiliation: Department of Obstetrics and Gynecology, Tainan Hospital, Department of Health, Tainan, Taiwan.
authors.forename: I-Wen
authors.initials: IW
authors.lastname: Lee
authors.forename: Mei-Tsz
authors.initials: MT
authors.lastname: Su
authors.forename: Chao-Chin
authors.initials: CC
authors.lastname: Hsu
authors.forename: Ying-Hui
authors.initials: YH
authors.lastname: Lin
authors.forename: Pei-Yi
authors.initials: PY
authors.lastname: Chen
authors.forename: Pao-Lin
authors.initials: PL
authors.lastname: Kuo
mesh_terms: D000328:Adult; D053713:Azoospermia / Q000175:diagnosis / Q000235:genetics*; D019457:Chromosome Breakage; D002882:Chromosomes, Human, Pair 13; D002891:Chromosomes, Human, Pair 21; D002899:Chromosomes, Human, Pair 9; D006801:Humans; D008297:Male; D012307:Risk Factors; D014178:Translocation, Genetic / Q000235:genetics*