Protective effect of thiazolo[5,4-b]indole in toxic pulmonary edema.
Antiedematous activity of new thiazolo[5,4-b]indole derivatives containing a fragment of isothiourea and characterized by higher antihypoxic activity compared to known antihypoxants was studied on a model of toxic edema of the lungs in mice. Compounds exhibiting high activity on two models of hypoxia (hypobaric and hemic) better protected from lung edema than compounds active only in hypobaric hypoxia.
Marysheva
V V
VV
Department of Pharmacology, S. M. Kirov Military Medical Academy, St. Petersburg.
Torkunov
P A
PA
Shabanov
P D
PD
D000818:Animals; D000860:Hypoxia; D007211:Indoles / Q000494:pharmacology*; D007700:Kinetics; D008168:Lung / Q000187:drug effects; D008297:Male; D051379:Mice; D008956:Models, Chemical; D010705:Phosgene / Q000378:metabolism; D011654:Pulmonary Edema / Q000188:drug therapy*; D051381:Rats; D013844:Thiazoles / Q000494:pharmacology*; D013890:Thiourea / Q000494:pharmacology
D007211:Indoles; D013844:Thiazoles; D010705:Phosgene; D013890:Thiourea