Receptor communication within the lymphocyte plasma membrane: a role for the thrombospondin family of matricellular proteins.
Lymphocytes, the principal cells of the immune system, carry out immune surveillance throughout the body by their unique capacity to constantly reposition themselves between a free-floating vascular state and a tissue state characterized by migration and frequent adhesive interactions with endothelial cells and components of the extracellular matrix. Therefore, mechanisms co-ordinating adhesion and migration with signals delivered through antigen recognition probably play a pivotal role for the regulation of lymphocyte behaviour and function. Endogenous thrombospondin-1 (TSP-1) seems to be the hub in such a mechanism for autocrine regulation of T cell adhesion and migration. TSP-1 functions as a mediator of cis interaction of vital receptors within the T lymphocyte plasma membrane, including integrins, low density lipoprotein receptor-related protein, calreticulin and integrin-associated protein.
Forslöw
A
A
Department of Laboratory Medicine, Division of Clinical Immunology, Karolinska Institute at Karolinska University Hospital Huddinge, SE-141 86, Stockholm, Sweden.
Liu
Z
Z
Sundqvist
K-G
KG
D000818:Animals; D019898:Autocrine Communication; D002448:Cell Adhesion; D002462:Cell Membrane / Q000378:metabolism; D002465:Cell Movement; D005109:Extracellular Matrix / Q000737:chemistry; D006801:Humans; D007107:Immune System / Q000502:physiology; D018448:Models, Immunological; D011956:Receptors, Cell Surface / Q000378:metabolism*; D013601:T-Lymphocytes / Q000166:cytology* / Q000276:immunology* / Q000378:metabolism; D019699:Thrombospondins / Q000737:chemistry / Q000378:metabolism*
D011956:Receptors, Cell Surface; D019699:Thrombospondins