[Application endoscopic mucosal resection to therapy early gastrointestinal cancer and precancerous lesion].
OBJECTIVE
To explore the clinical value of endoscopic mucosal resection (EMR) on early gastrointestinal cancer and precancerous lesion.


METHODS
The EMR data of 42 lesions from 28 patients, collected from Apr. 2001 to Dec. 2005, were retrospectively analyzed. All the lesions were confirmed histologically before and after operation.


RESULTS
Forty-two lesions were removed by the EMR from 28 patients. Lesion types observed under endoscopy were as follows: type I 9 lesions (type Isp 2 lesions, type Is 7 lesions), type II 33 lesions (type IIa 23 lesions, type IIa + IIc 4 lesions, type IIb 6 lesions). Thirty-eight EMRs were performed by using snare resection techniques and 4 EMRs by using suction cap-assisted techniques. The size of lesions changed from 0.6 cm x 0.6 cm to 3.0 cm x 3.5 cm. Complete resections were achieved in 36 of 40, among them, 2 lesions were divided into 2 pieces and 1 lesion was divided into 3 pieces. Post-EMR histopathologic evaluation revealed the following


RESULTS
carcinoma in 4 lesions, high-grade dysplasia (HGD) in 11 lesions, middle-grade dysplasia (MGD) in 17 lesions, adenoma in 6 lesions, non-adenoma in 2 lesions. The pathology match rate between local biopsy and EMR was 60.0%. The detection rates of cancer, HGD and MGD by EMR were higher than that by routine biopsy. No serious complications were seen in this study.


CONCLUSIONS
Endoscopic mucosal resection has significant impact on the endoscopic intervention treatment of early cancer and precancerous lesion in digestive tract.
Ou
Xi-long
XL
Department of Gastroenterology, Affiliated Zhongda Hospital of Southeast University, Nanjing 210009, China. Ouxilong@126.com
Sun
Wei-hao
WH
Cao
Da-zhong
DZ
Yu
Qian
Q
Yu
Ting
T
Yan
Fang
F
Zhang
You-zhen
YZ
Wu
Zi-ying
ZY
Liu
Shun-ying
SY
D000328:Adult; D000368:Aged; D004724:Endoscopy; D004938:Esophageal Neoplasms / Q000601:surgery; D004945:Esophagoscopy / Q000379:methods; D005260:Female; D005743:Gastrectomy / Q000379:methods; D005753:Gastric Mucosa / Q000473:pathology / Q000601:surgery*; D005770:Gastrointestinal Neoplasms / Q000473:pathology / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011230:Precancerous Conditions / Q000473:pathology / Q000601:surgery; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000601:surgery