Three-dimensional structure of S-adenosyl-L-homocysteine hydrolase from Plasmodium falciparum.
Structural information of Plasmodium falciparum S-adenosyl-L-homocysteine hydrolase (PfSAHH) has been expected to provide new-type chemotherapeutic agents against malaria. Here we report the crystal structure of PfSAHH. The present structure should provide opportunities to design potent and selective PfSAHH inhibitors.
Tanaka
Nobutada
N
School of Pharmaceutical Sciences, Showa University, Tokyo 142-8555, Japan.
Nakanishi
Masayuki
M
Kusakabe
Yoshio
Y
Shiraiwa
Katsura
K
Yabe
Saori
S
Ito
Yasutomo
Y
Kitade
Yukio
Y
Nakamura
Kazuo T
KT
D043383:Adenosylhomocysteinase / Q000737:chemistry*; D000818:Animals; D003460:Crystallization; D018360:Crystallography, X-Ray; D010963:Plasmodium falciparum / Q000201:enzymology*
D043383:Adenosylhomocysteinase