Wnt signaling and gastrointestinal tumorigenesis in mouse models.
The canonical Wnt signaling plays important roles in embryonic development and tumorigenesis. For the latter, induced mutations in mice have greatly contributed to our understanding of the molecular mechanisms of cancer initiation and progression. Here, I will review recent reports on gastrointestinal cancer model mice, with an emphasis on the roles of the Wnt signal pathway. They include: mouse models for familial adenomatous polyposis; modifying factors that affect mouse intestinal polyposis, including the genes that help cancer progression; Wnt target genes that affect mouse intestinal polyposis; and a mouse model of gastric cancer that mimics Helicobacter pyroli infection.
Taketo
M M
MM
Department of Pharmacology, Graduate School of Medicine, Kyoto University, Yoshida-Konoé-cho, Sakyo, Kyoto, Japan. taketo@mfour.med.kyoto-u.ac.jp
D011125:Adenomatous Polyposis Coli / Q000235:genetics; D000818:Animals; D004195:Disease Models, Animal; D018450:Disease Progression; D005770:Gastrointestinal Neoplasms / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D008954:Models, Biological; D009154:Mutation; D015398:Signal Transduction; D051153:Wnt Proteins / Q000235:genetics / Q000502:physiology*
D051153:Wnt Proteins