title: Use of capillaries in the construction of an MRI phantom for the assessment of diffusion tensor imaging: demonstration of performance.
abstract: Although diffusion tensor imaging (DTI) shows great potential for the diagnosis of a variety of pathologies, no consensus for an appropriate assessment standard of DTI exists. This study examined the feasibility of using water-filled arrays of glass capillaries to construct a DTI phantom suitable for making repeated and reproducible measurements required in a quality assessment program. Three phantoms were constructed using arrays of capillaries with three inner diameters (23, 48, and 82 microm). Data were acquired using DTI protocols; the fractional anisotropy (FA), mean apparent diffusion coefficient (ADC) and principal eigenvectors of the diffusion tensors were calculated. This study demonstrated four results: (1) echo-planar images show that susceptibility within the capillary arrays does not lead to substantial differences in precessional frequency in regions containing the arrays and neither do the regions show noticeable image distortion; (2) principal eigenvectors of the diffusion tensors agree to within<10.3 degrees of the array orientations; (3) mean FA values (0.18-0.50) and ADC values (1.40-1.93x10-(3) mm2/s) within specified regions of interest are in general agreement with simulations after a simple noise correction; and (4) these array performance characteristics are observable using a typical clinical DTI protocol.
authors.affiliation: Department of Radiology, Medical College of Georgia, Augusta, GA 30912, USA. nyanasak@mcg.edu
authors.forename: Nathan
authors.initials: N
authors.lastname: Yanasak
authors.forename: Jerry
authors.initials: J
authors.lastname: Allison
mesh_terms: D016880:Anisotropy; D002196:Capillaries / Q000033:anatomy & histology*; D003198:Computer Simulation; D038524:Diffusion Magnetic Resonance Imaging; D005240:Feasibility Studies; D006801:Humans; D008962:Models, Theoretical; D009010:Monte Carlo Method; D019047:Phantoms, Imaging