title: Necrotizing fasciitis due to a methicillin-sensitive Staphylococcus aureus isolate harboring an enterotoxin gene cluster.
abstract: Benign papular eruption on the left leg of a 72-year-old diabetic man developed into rapidly spreading necrotizing fasciitis despite antimicrobial therapy and surgical debridements. This led to eventual amputation to control the infection. The etiological agent was a Staphylococcus aureus isolate harboring the enterotoxin gene cluster seg, sei, sem, sen, and seo but lacked all common toxin genes, including Panton-Valentine leukocidin.
authors.affiliation: Department of Internal Medicine, Marshfield Clinic, Marshfield, Wisconsin, USA.
authors.forename: William R
authors.initials: WR
authors.lastname: Morgan
authors.forename: Michael D
authors.initials: MD
authors.lastname: Caldwell
authors.forename: Jennifer M
authors.initials: JM
authors.lastname: Brady
authors.forename: Mary E
authors.initials: ME
authors.lastname: Stemper
authors.forename: Kurt D
authors.initials: KD
authors.lastname: Reed
authors.forename: Sanjay K
authors.initials: SK
authors.lastname: Shukla
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004768:Enterotoxins / Q000235:genetics*; D019115:Fasciitis, Necrotizing / Q000382:microbiology* / Q000473:pathology; D006801:Humans; D007866:Leg / Q000473:pathology; D008297:Male; D008712:Methicillin / Q000494:pharmacology*; D005810:Multigene Family; D013203:Staphylococcal Infections / Q000382:microbiology / Q000473:pathology; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000235:genetics / Q000472:pathogenicity; D018089:Superantigens / Q000235:genetics; D014774:Virulence
chemical_list: D000900:Anti-Bacterial Agents; D004768:Enterotoxins; D018089:Superantigens; C419397:enterotoxin G, staphylococcal; C419398:enterotoxin I, staphylococcal; D008712:Methicillin