title: Wave dissipation in flexible tubes in the time domain: in vitro model of arterial waves.
abstract: Earlier work of wave dissipation in flexible tubes and arteries has been carried out predominantly in the frequency domain and most of the studies used the measured pressure waveform for presenting the results. In this work we investigate the pattern of wave dissipation in the time domain using the separated forward and backward travelling waves in flexible tubes. We tested four sizes of latex tubes of 2m in length each, where a single semi-sinusoidal in shape, pressure wave, was produced at the inlet of each tube. Simultaneous measurements of pressure and flow waveforms were recorded every 5cm along the tubes and wave speed was determined using the pressure-velocity loop method (PU-loop). The measured data and wave speed were used to separate the pressure waveform and wave intensity, into their forward and backward directions, using wave intensity analysis (WIA). Also, the energy carried by the wave was calculated by integrating the relevant area under the wave intensity curve. The peak of the measured pressure waveform increased downstream, however, the peak of the separated forward pressure waveform decreased exponentially along the tube. Wave intensity and energy also dissipated exponentially along the travelling distance. The peaks of the separated pressure and wave intensity decreased in the forward in a similar exponential way to that in the backward direction in all four tube sizes. Also, the smaller the size of the tube the greater wave dissipation it caused. We conclude that wave separation is useful in studying wave dissipation in elastic tubes, and WIA provides a convenient method for determining the dissipation of the energy carried by the wave along the travelled distance. The separated pressure waveform, wave intensity and wave energy dissipate exponentially with the travelling distance, and wave dissipation varies conversely with the diameter of elastic tubes.
authors.affiliation: Brunel Institute for Bioengineering and School of Engineering and Design, Brunel University, Uxbridge, Middlesex, UK.
authors.forename: J
authors.initials: J
authors.lastname: Feng
authors.forename: Q
authors.initials: Q
authors.lastname: Long
authors.forename: A W
authors.initials: AW
authors.lastname: Khir
mesh_terms: D000818:Animals; D001158:Arteries / Q000502:physiology*; D001783:Blood Flow Velocity / Q000502:physiology; D004548:Elasticity; D006801:Humans; D008955:Models, Cardiovascular; D011673:Pulsatile Flow / Q000502:physiology; D012212:Rheology; D017725:Ventricular Pressure / Q000502:physiology