Phase transfer catalyzed enantioselective Strecker reactions of alpha-amido sulfones with cyanohydrins.
A study into the use of a chiral phase-transfer catalyst in conjunction with acetone cyanohydrin to effect the enantioselective formation of alpha-amino nitriles from alpha-amido sulfones is described. This novel catalytic asymmetric Strecker reaction is analyzed with regard to the possible mechanistic basis.
Herrera
Raquel P
RP
Department of Organic Chemistry A. Mangini, University of Bologna, V. Risorgimento 4, 40136 Bologna, Italy. rph@alu.ua.es
Sgarzani
Valentina
V
Bernardi
Luca
L
Fini
Francesco
F
Pettersen
Daniel
D
Ricci
Alfredo
A
D002254:Carbonates / Q000737:chemistry; D002384:Catalysis; D015394:Molecular Structure; D009570:Nitriles / Q000138:chemical synthesis* / Q000737:chemistry; D044367:Phase Transition; D011188:Potassium / Q000737:chemistry; D013237:Stereoisomerism; D013450:Sulfones / Q000737:chemistry*; D014867:Water / Q000737:chemistry
D002254:Carbonates; D009570:Nitriles; D013450:Sulfones; C430593:cyanohydrin; D014867:Water; C037593:potassium carbonate; D011188:Potassium