title: Synthesis and biological evaluation of new conformationally biased integrin ligands based on a tetrahydroazoninone scaffold.
abstract: The synthesis of new conformationally biased cyclic pentapeptides, incorporating the RGD sequence, and built around a tetrahydroazoninone scaffold, is reported. They exhibit interesting activity towards integrin alphaVbeta3 and a remarkable selectivity in comparison with integrin alphaVbeta5.
authors.affiliation: Department of Chemistry and Industrial Chemistry, via Dodecaneso 31, 16146 Genova, Italy. banfi@chimica.unige.it
authors.forename: Luca
authors.initials: L
authors.lastname: Banfi
authors.forename: Andrea
authors.initials: A
authors.lastname: Basso
authors.forename: Gianluca
authors.initials: G
authors.lastname: Damonte
authors.forename: Federico
authors.initials: F
authors.lastname: De Pellegrini
authors.forename: Andrea
authors.initials: A
authors.lastname: Galatini
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Guanti
authors.forename: Ilaria
authors.initials: I
authors.lastname: Monfardini
authors.forename: Renata
authors.initials: R
authors.lastname: Riva
authors.forename: Carlo
authors.initials: C
authors.lastname: Scapolla
mesh_terms: D001391:Azo Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D039302:Integrin alphaVbeta3 / Q000378:metabolism; D016023:Integrins / Q000378:metabolism*; D008024:Ligands; D008968:Molecular Conformation; D009842:Oligopeptides; D010456:Peptides, Cyclic / Q000138:chemical synthesis* / Q000494:pharmacology*; D019030:Receptors, Vitronectin / Q000378:metabolism; D013329:Structure-Activity Relationship; D013379:Substrate Specificity
chemical_list: D001391:Azo Compounds; D039302:Integrin alphaVbeta3; D016023:Integrins; D008024:Ligands; D009842:Oligopeptides; D010456:Peptides, Cyclic; D019030:Receptors, Vitronectin; C064660:integrin alphaVbeta5; C047981:arginyl-glycyl-aspartic acid