[Process mechanism of Atractylodes macrocephala and conversion of sesquiterpenes].
OBJECTIVE
To research the process mechanism of Atractylodes macrocephala and conversion of sesquiterpenes from it.


METHODS
The contents of atractylenolide I, II and III in the different processed herbal medicines were determined by HPLC. The conversion of the sesquiterpenes was proved by the separation of oxides of atractylone.


RESULTS
The contents of atractylenolide I and III increased after frying, and at high temperature the content of atract ylenolide III decreased. After oxidation, atractylone converted to atractylenolide I, III and biatractylenolide, and atractylenolide III converted to atractylenolide II after dehydration when heated.


CONCLUSIONS
Atractylone can convert to atractylenolides during process of A. macrocephala, and the contents of each component are related to the level of process.
Li
Wei
W
Nanjing University of Traditional Chinese Medicine, Nanjing 210029, China.
Wen
Hong-Mei
HM
Cui
Xiao-Bing
XB
Zhang
Ke-Wei
KW
D031174:Atractylodes / Q000737:chemistry*; D003890:Desiccation; D006358:Hot Temperature; D007783:Lactones / Q000032:analysis* / Q000737:chemistry; D015394:Molecular Structure; D010084:Oxidation-Reduction; D010946:Plants, Medicinal / Q000737:chemistry*; D027343:Rhizome / Q000737:chemistry; D012717:Sesquiterpenes / Q000032:analysis* / Q000737:chemistry; D013678:Technology, Pharmaceutical / Q000379:methods*; D013696:Temperature
D007783:Lactones; D012717:Sesquiterpenes; C424804:atractylenolide I; C458582:atractylenolide II; C424802:atractylenolide III