Allergic contact dermatitis from pimecrolimus in a patient with tacrolimus allergy.
A 15-year-old male with previously documented allergic contact dermatitis from tacrolimus was allergic to pimecrolimus. This was demonstrated by double-blinded, right-versus-left provocative use testing with pimecrolimus cream 1% versus inactive vehicle applied twice daily to normal skin. The active cream but not its vehicle caused preauricular dermatitis starting after 1 week and caused isolated papules on the extensor wrist starting after 2 weeks. Patch testing on the patient's back was weakly positive (1+) with pimecrolimus cream 1% and negative with the vehicle. Higher concentrations of pimecrolimus were not available for testing. Patch tests on 30 control patients with pimecrolimus cream 1% were negative.
Shaw
Daniel W
DW
Department of Medicine, Division of Dermatology, University of California, San Diego 92103-8420, USA. dwshaw@ucsd.edu
Maibach
Howard I
HI
Eichenfield
Lawrence F
LF
D000293:Adolescent; D017449:Dermatitis, Allergic Contact / Q000276:immunology*; D003876:Dermatitis, Atopic / Q000188:drug therapy*; D003879:Dermatologic Agents / Q000009:adverse effects*; D004342:Drug Hypersensitivity / Q000276:immunology*; D006801:Humans; D007166:Immunosuppressive Agents / Q000276:immunology*; D008297:Male; D010328:Patch Tests; D016559:Tacrolimus / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000276:immunology*
D003879:Dermatologic Agents; D007166:Immunosuppressive Agents; C117268:pimecrolimus; D016559:Tacrolimus