The effect of treatment with crotapotin on the evolution of experimental autoimmune neuritis induced in Lewis rats.
Biomedical research in which venom components are being investigated for their potential as novel therapeutic agents has emerged as an interesting option. Crotapotin, which is purified from the venom of the rattlesnake Crotalus durissus terrificus, has been described as an anti-inflammatory agent that acts on the innate arm of the immune response. Here we have demonstrated that intraperitoneal administration of crotapotin significantly reduces the severity of experimental autoimmune neuritis (EAN), an experimental model for Guillain-Barré syndrome. The reduction of the severity of the disease is associated with a reduction in the mononuclear cells infiltrating the sciatic nerve and a significant decrease in the lymphocyte proliferative response to neuritogenic peptide.
Castro
Fabiano R
FR
Neuroimmunology Unit, Department of Microbiology and Immunology, University of Campinas, UNICAMP, Campinas, SP, Brazil.
Farias
Alessandro S
AS
Proença
Patricia L F
PL
de La Hoz
Cristiane
C
Langone
Francesco
F
Oliveira
Elaine C
EC
Toyama
Marcos H
MH
Marangoni
Sergio
S
Santos
Leonilda M B
LM
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D002851:Chromatography, High Pressure Liquid; D017839:Crotalus; D003439:Crotoxin / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004306:Dose-Response Relationship, Immunologic; D005260:Female; D020275:Guillain-Barre Syndrome; D007274:Injections, Intraperitoneal; D007963:Leukocytes, Mononuclear / Q000187:drug effects / Q000473:pathology; D008198:Lymph Nodes / Q000187:drug effects / Q000473:pathology; D008213:Lymphocyte Activation; D009185:Myelin Proteins / Q000276:immunology / Q000494:pharmacology; D009444:Neuritis, Autoimmune, Experimental / Q000276:immunology / Q000473:pathology / Q000517:prevention & control*; D051381:Rats; D011917:Rats, Inbred Lew; D012584:Sciatic Nerve / Q000187:drug effects / Q000473:pathology; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology
D000893:Anti-Inflammatory Agents; D009185:Myelin Proteins; C425263:P2 peptide; D003439:Crotoxin