Photoirradiation of polycyclic aromatic hydrocarbons with UVA light - a pathway leading to the generation of reactive oxygen species, lipid peroxidation, and dna damage.
Polycyclic aromatic hydrocarbons (PAHs) are a class of genotoxic environmental contaminants. We have long been interested in determining the mechanisms by which PAHs induce genotoxicity. Although the metabolic activation of PAHs leading to biological activities has been well studied, the photo-induced activation pathway has seldom reported. In this paper, we review the study of photoirradiation of PAHs with UVA irradiation results in (i) cytotoxicity and DNA damage (ii) DNA single strand cleavage; (iii) formation of 8-hydroxy-2'-deoxyguanosine adduct (8-OHdG), and (iv) formation of lipid peroxidation. Evidence has been shown that these photobiological activities are mediated by reactive oxygen species (ROS).
Yu
Hongtao
H
Department of Chemistry, Jackson State University, Jackson, MS 39217, USA. hongtao.yu@jsums.edu
Xia
Qingsu
Q
Yan
Jian
J
Herreno-Saenz
Diogenes
D
Wu
Yuh-Shen
YS
Tang
I-Wah
IW
Fu
Peter P
PP
D018736:DNA Adducts / Q000138:chemical synthesis / Q000528:radiation effects; D004249:DNA Damage; D004277:DNA, Single-Stranded / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects; D004785:Environmental Pollutants / Q000528:radiation effects / Q000633:toxicity; D006147:Guanine / Q000031:analogs & derivatives / Q000138:chemical synthesis; D008027:Light / Q000009:adverse effects; D015227:Lipid Peroxidation / Q000187:drug effects / Q000528:radiation effects; D008954:Models, Biological; D008962:Models, Theoretical; D010777:Photochemistry; D011084:Polycyclic Aromatic Hydrocarbons / Q000138:chemical synthesis / Q000528:radiation effects* / Q000633:toxicity*; D017382:Reactive Oxygen Species / Q000138:chemical synthesis*; D015398:Signal Transduction / Q000528:radiation effects; D014466:Ultraviolet Rays
D018736:DNA Adducts; D004277:DNA, Single-Stranded; D004785:Environmental Pollutants; D011084:Polycyclic Aromatic Hydrocarbons; D017382:Reactive Oxygen Species; C095911:polycyclic aromatic hydrocarbons-DNA adduct; C024829:8-hydroxyguanine; D006147:Guanine