Electrochemotherapy of Mycosis fungoides by interferon-alpha.
Eight patients with 29 lesions of histologically verified 1st stage of Mycosis fungoides were successfully treated by electrochemotherapy with interferon-alpha. For this purpose 8 biphasic pulses were used, each of 50+50 micros duration with 900 micros interpulse intervals, resulting in a burst of 7.1 ms total duration. Compared to the traditional monoimmunotherapy with interferon-alpha applied three times weekly for a total of 4 weeks, the electrochemotherapy was very efficient. Complete response (CR) was observed in 25 (86%) of the 29 treated lesions by single-act electrochemotherapy with interferon-alpha. At the end of the 12-month period, all 29 lesions showed 100% complete response (CR). New lesions for a period of 12 months were not observed. The expected mechanism involved in multiple cytotoxic action of interferon-alpha could be the local increased concentration in the tumour and prolongation of the time of its action after the application of pulses.
Peycheva
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E
National Centre of Oncology, Clinic of Oncodermatology, 6 Plovdivsko pole Blv., 1756 Sofia, Bulgaria.
Daskalov
I
I
Tsoneva
I
I
D020533:Angiogenesis Inhibitors / Q000008:administration & dosage; D000970:Antineoplastic Agents / Q000008:administration & dosage; D053672:Electrochemotherapy / Q000379:methods*; D006801:Humans; D015552:Injections, Intralesional / Q000379:methods; D016898:Interferon-alpha / Q000008:administration & dosage*; D009182:Mycosis Fungoides / Q000188:drug therapy* / Q000473:pathology*; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D016896:Treatment Outcome
D020533:Angiogenesis Inhibitors; D000970:Antineoplastic Agents; D016898:Interferon-alpha