title: Mortality in patients with Parkinson's disease treated by stimulation of the subthalamic nucleus.
abstract: Subthalamic nucleus (STN) stimulation improves motor disability and quality of life in patients with advanced Parkinson's disease (PD). Short-term mortality is low, but little is known about long-term mortality. We assessed mortality and causes of death in 171 consecutive PD patients treated by STN stimulation. Surgery was performed after a median lagtime of 13 years from PD onset at a median age of 57 years. The median follow-up after surgery was 41 months. Sixteen patients died 8 to 83 months after neurosurgery. Poorer cognitive function was the only predictive factor for mortality (standardized mortality ratio = 2.9; 95% confidence interval [CI], 1.6-4.7; P < 0.0001). Based on a historical comparison of 118 operated patients with 39 nonoperated patients from a different population, survival among operated patients was not better (hazard ratio = 1.2; 95% CI, 0.7-2.1).
authors.affiliation: Centre d'Investigation Clinique, Fédération de Neurologie and National Institute of Health and Medical Research (INSERM) Unit 679 (former Unit 289), Hôpital de la Salpêtrière, Paris, France.
authors.forename: Michael W M
authors.initials: MW
authors.lastname: Schüpbach
authors.forename: Marie Laure
authors.initials: ML
authors.lastname: Welter
authors.forename: Anne Marie
authors.initials: AM
authors.lastname: Bonnet
authors.forename: Alexis
authors.initials: A
authors.lastname: Elbaz
authors.forename: Brandon R
authors.initials: BR
authors.lastname: Grossardt
authors.forename: Valerie
authors.initials: V
authors.lastname: Mesnage
authors.forename: Jean Luc
authors.initials: JL
authors.lastname: Houeto
authors.forename: David
authors.initials: D
authors.lastname: Maltête
authors.forename: Luc
authors.initials: L
authors.lastname: Mallet
authors.forename: Walter A
authors.initials: WA
authors.lastname: Rocca
authors.forename: Alain
authors.initials: A
authors.lastname: Mallet
authors.forename: Yves
authors.initials: Y
authors.lastname: Agid
mesh_terms: D000328:Adult; D000368:Aged; D002423:Cause of Death; D003072:Cognition Disorders / Q000175:diagnosis; D046690:Deep Brain Stimulation / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D010300:Parkinson Disease / Q000453:epidemiology / Q000401:mortality* / Q000628:therapy*; D011184:Postoperative Period; D011237:Predictive Value of Tests; D020531:Subthalamic Nucleus / Q000502:physiology*; D015996:Survival Rate