title: Metal ion binding of substituted pyrimidine base pairs in DNA duplexes.
abstract: DNA duplexes containing 5-substituted uracil pairs and N4-substituted cytosine pairs have been chemically prepared and interactions between the duplexes and metal ions have been investigated. Substitutions at the 5-position with the electron withdrawing groups, such as bromo, fluoro and cyano groups, largely alter the binding selectivity of the duplexes and the metal ions.
authors.affiliation: Department of Chemistry, Graduate School and Faculty of Science, Tokyo Metropolitan University, 1-1 Minami-ohsawa, Hachioji, Tokyo 192-0397, Japan.
authors.forename: Yuko
authors.initials: Y
authors.lastname: Watanabe
authors.forename: Takahiro
authors.initials: T
authors.lastname: Minowa
authors.forename: Akira
authors.initials: A
authors.lastname: Ono
mesh_terms: D020029:Base Pairing; D001483:Base Sequence; D003596:Cytosine / Q000737:chemistry*; D004247:DNA / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D008670:Metals / Q000737:chemistry*; D008969:Molecular Sequence Data; D009691:Nucleic Acid Denaturation; D009692:Nucleic Acid Heteroduplexes / Q000737:chemistry*; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis / Q000737:chemistry; D013696:Temperature; D014498:Uracil / Q000737:chemistry*
chemical_list: D008670:Metals; D009692:Nucleic Acid Heteroduplexes; D009838:Oligodeoxyribonucleotides; D014498:Uracil; D003596:Cytosine; D004247:DNA