Eosinophilic myocarditis: case series and review of literature.
Although the etiology of eosinophilic myocarditis (EM) is not always apparent, several causes are identified, including hypersensitivity to a drug or substance, with the heart as the target organ. However, symptoms and signs of hypersensitivity are not found in all patients. EM can lead to progressive myocardial damage with destruction of the conduction system and refractory heart failure. The present report describes three cases of biopsy-proven EM with different presentations, including acute coronary syndrome, cardiogenic shock and newly diagnosed heart failure. In one patient, hypersensitivity to sumatriptan was suspected to be the underlying cause. All patients responded well to treatment with steroids, angiotensin-converting enzyme inhibitors and beta-blockers. There was a complete recovery of the ventricular function in all cases.
Al Ali
Abdullah M
AM
Division of Cardiology, Department of Medicine, St Paul's Hospital, University of British Columbia, Vancouver.
Straatman
Lynn P
LP
Allard
Michael F
MF
Ignaszewski
Andrew P
AP
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D000328:Adult; D000789:Angina, Unstable / Q000188:drug therapy / Q000209:etiology; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D004802:Eosinophilia / Q000139:chemically induced / Q000175:diagnosis* / Q000188:drug therapy; D005938:Glucocorticoids / Q000627:therapeutic use; D006333:Heart Failure / Q000188:drug therapy / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy / Q000209:etiology; D009205:Myocarditis / Q000139:chemically induced / Q000175:diagnosis* / Q000188:drug therapy; D009206:Myocardium / Q000473:pathology; D009336:Necrosis; D011241:Prednisone / Q000627:therapeutic use; D017366:Serotonin Receptor Agonists / Q000009:adverse effects; D012770:Shock, Cardiogenic / Q000188:drug therapy / Q000209:etiology; D018170:Sumatriptan / Q000009:adverse effects
D000319:Adrenergic beta-Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors; D005938:Glucocorticoids; D017366:Serotonin Receptor Agonists; D018170:Sumatriptan; D011241:Prednisone