[Analysis the clinic and cytogenetics of myelodysplastic syndrome].
OBJECTIVE
To analysis the relationship among cytogenetics, morphology and prognosis of the myelodysplastic syndrome (MDS) patients.


METHODS
Cytogenetics analysis of bone marrow cells was performed by direct method and/or 24 h culture method. The karyotype was analysed by R banding technique.


RESULTS
Out of the 50 MDS patients, 22 were found with abnormal karyotype: two of them were +8, four of them were -7, four of them were 5q-, nine of them were 7q-, two of them were 20q- and one of them was 6q-. There are six patients had complex changes in chromosome.


CONCLUSIONS
5q-, -7, 7q- are the most classic translocation in the MDS. The patients with 5q- have better prognosis and the patients with -7, 7q- have worse prognosis. Cytogenetics is very important in the MDS's diagnosis, progress and prognosis.
Cen
Ling
L
Department of Blood Laboratory, Changzhou No.2 People's Hospital, Changzhou, Jiangsu, 213003, P. R. China. cenling76@yahoo.com.cn
Zhou
Min
M
Zhao
Ying-hao
YH
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002869:Chromosome Aberrations; D002872:Chromosome Deletion; D002895:Chromosomes, Human, Pair 5; D002897:Chromosomes, Human, Pair 7; D005260:Female; D006801:Humans; D007621:Karyotyping; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000235:genetics*; D011379:Prognosis