title: Enantioselective direct aza hetero-Diels-Alder reaction catalyzed by chiral Brønsted acids.
abstract: [Structure: see text] The first chiral Brønsted acid-catalyzed asymmetric direct aza hetero-Diels-Alder reaction has been described. The phosphoric acids, prepared from binol and H8-binol derivatives, have shown catalytic ability for the reaction of cyclohexenone with N-PMP-benzaldimine. A chiral phosphoric acid, derived from 3,3-di(4-chloropheneyl)-H8-binol, exhibited superior enantioselectivity, affording fairly good yields and enantioselectivities for the reaction of a range of aromatic aldimines with cyclohexenone.
authors.affiliation: Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, University of Science and Technology of China, Hefei, 230026, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Liu
authors.forename: Lin-Feng
authors.initials: LF
authors.lastname: Cun
authors.forename: Ai-Qiao
authors.initials: AQ
authors.lastname: Mi
authors.forename: Yao-Zhong
authors.initials: YZ
authors.lastname: Jiang
authors.forename: Liu-Zhu
authors.initials: LZ
authors.lastname: Gong