title: Infectious haemolytic anaemia causes jaundice outbreaks in seawater-cultured coho salmon, Oncorhynchus kisutch (Walbaum), in Chile.
abstract: In the last 9 years, epizootics of an icterus condition has affected coho salmon, Oncorhynchus kisutch (Walbaum), reared in seawater cages in southern regions of Chile. At necropsy, fish from field cases exhibited signs of jaundice accompanied by pale light-brown livers and dark spleens. Histopathological and haematological results indicated that these fish presented haemolytic anaemia. After microbiological examination no bacterial or viral agents could be identified as aetiological agents of this disease. In an infectivity trial, coho salmon, Atlantic salmon, Salmo salar L., and rainbow trout, Oncorhynchus mykiss (Walbaum), were inoculated intraperitoneally with a filtrate of an organ homogenate (0.45 microm) from a diseased coho salmon and held for 60 days in tanks supplied with fresh water. The disease was only reproduced in coho salmon in which mortalities, beginning at day 23 post-inoculation (p.i.), reached a cumulative value of 24% at day 27 p.i. This condition was transmitted to non-inoculated cohabiting coho salmon suggesting that it is a waterborne disease. Thus, this icteric condition is caused by an infectious form of haemolytic anaemia, probably of viral aetiology, and coho salmon are more susceptible than either Atlantic salmon or rainbow trout.
authors.affiliation: Unit of Pathology of Aquatic Animals, Department of Animal Pathology, Faculty of Veterinary Sciences, University of Chile, Santiago de Chile, Chile. psmith@uchile.cl
authors.forename: P A
authors.initials: PA
authors.lastname: Smith
authors.forename: J
authors.initials: J
authors.lastname: Larenas
authors.forename: J
authors.initials: J
authors.lastname: Contreras
authors.forename: J
authors.initials: J
authors.lastname: Cassigoli
authors.forename: C
authors.initials: C
authors.lastname: Venegas
authors.forename: M E
authors.initials: ME
authors.lastname: Rojas
authors.forename: A
authors.initials: A
authors.lastname: Guajardo
authors.forename: S
authors.initials: S
authors.lastname: Pérez
authors.forename: S
authors.initials: S
authors.lastname: Díaz
mesh_terms: D000743:Anemia, Hemolytic / Q000473:pathology / Q000662:veterinary*; D000818:Animals; D017756:Aquaculture; D002677:Chile / Q000453:epidemiology; D004196:Disease Outbreaks; D005393:Fish Diseases / Q000097:blood / Q000473:pathology*; D007565:Jaundice / Q000453:epidemiology / Q000473:pathology / Q000662:veterinary*; D017684:Oncorhynchus kisutch; D012623:Seawater