Dysfunction of ionic channels in cardiomyocyte sarcolemma and cardiac arrhythmias.
The arrhythmic effects of Na+ and Ca2+ intracellular imbalance were examined on rats with aconitine-induced cardiac arrhythmias. Under conditions of Na(+)-dependent arrhythmogenesis, blockade of Ca(2+)-channels with verapamil aggravated cardiac rhythm disturbances. Correction of ionic imbalance by intravenous injection of calcium preparations in aconitine-induced arrhythmia promoted recovery of stable sinus rhythm and decreased animal mortality. Intracellular imbalance of Na+ and Ca2+ ions can underlie the arrhythmogenic effects of antiarrhythmic drugs.
Moroz
V M
VM
Vinnitsa National University of Medicine.
Lipnitskii
T N
TN
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology; D001145:Arrhythmias, Cardiac / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology*; D002118:Calcium / Q000378:metabolism; D005260:Female; D007473:Ion Channels / Q000378:metabolism; D007477:Ions / Q000737:chemistry*; D008297:Male; D032383:Myocytes, Cardiac / Q000378:metabolism*; D051381:Rats; D012508:Sarcolemma / Q000378:metabolism*; D012964:Sodium / Q000378:metabolism; D013997:Time Factors
D000889:Anti-Arrhythmia Agents; D007473:Ion Channels; D007477:Ions; D012964:Sodium; D002118:Calcium