Effect of xenogenic immobilized bone matrix on the course of wound process.
The effect of xenogenic demineralized bone matrix as a component of film coating on healing of a full-thickness skin wound was studied. Regenerative processes were more intensive in wounds dressed with a complex film containing demineralized bone matrix than in uncovered wounds and wounds covered with films without bone matrix. Film coating with antibiotics suppressed the development of wound microflora. In vitro experiments demonstrated different effects of demineralized bone matrix on some enzymes in rat skin and liver homogenates. Biological activity of xenogenic demineralized bone matrix as a component of wound coating is shown.
Anfimov
P E
PE
Nizhny Novgorod Institute of Traumatology and Orthopedics, Ministry of Health of Russian Federation.
Zimin
Yu V
YV
Denisov
V M
VM
Bushuev
Yu I
YI
Pylaeva
S I
SI
Krasnova
N S
NS
D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D001857:Bone Matrix / Q000378:metabolism*; D001842:Bone and Bones / Q000473:pathology*; D015496:CD4-Positive T-Lymphocytes / Q000378:metabolism; D008099:Liver / Q000378:metabolism / Q000382:microbiology; D008214:Lymphocytes / Q000378:metabolism; D008297:Male; D051381:Rats; D013997:Time Factors; D014945:Wound Healing
D001672:Biocompatible Materials