Synthesis and antiviral properties of aza-analogues of acyclovir.
Aza-analogues of Acyclovir were obtained from N-(2-pivaloyloxyethyl)-N-(pivaloyloxymethyl)-p-toluenesulfonamide via a one-pot base silylation/nucleoside coupling procedure. The antiviral activities of all aza-nucleosides in vitro against a variety of viruses were evaluated. None of these compounds displayed any specific antiviral effects.
Koszytkowska-Stawińska
Mariola
M
Faculty of Chemistry, Warsaw University of Technology, Warszawa, Poland. mkoszyt@ch.pw.edu.pl
Kaleta
Katarzyna
K
Sas
Wojciech
W
De Clercq
Erik
E
D000212:Acyclovir / Q000031:analogs & derivatives*; D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D002522:Chlorocebus aethiops; D006367:HeLa Cells; D006801:Humans; D009705:Nucleosides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D013449:Sulfonamides / Q000737:chemistry; D014709:Vero Cells; D014780:Viruses / Q000187:drug effects
D000998:Antiviral Agents; C518809:N-(2-pivaloyloxyethyl)-N-(pivaloyloxymethyl)-4-toluenesulfonamide; D009705:Nucleosides; D013449:Sulfonamides; D000212:Acyclovir