[Nitrates in the practice of treatment of cardiovascular diseases].
Mechanisms of emergence of endothelial dysfunction underlying development of ischemic heart disease with peculiarities of its 24-hour cycles are considered in detail. Data on metabolism of organic nitrates, determining basis of "replacement" therapy with nitrates in deficit of nitric oxide (endothelium dependent factor of relaxation) are summarized. Results of multicenter controlled studies on comparative assessment of therapeutic efficacy of tri-, di-, and mononitrates are discussed. High antianginal efficacy of once daily administration of a drug with original pharmacokinetics--isosorbide-5-mononitrate in good tolerability and minimal side effects is shown.
Shilov
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AM
D000787:Angina Pectoris / Q000188:drug therapy; D002318:Cardiovascular Diseases / Q000188:drug therapy*; D006801:Humans; D007548:Isosorbide Dinitrate / Q000031:analogs & derivatives; D009566:Nitrates / Q000627:therapeutic use*; D014665:Vasodilator Agents / Q000627:therapeutic use
D009566:Nitrates; D014665:Vasodilator Agents; D007548:Isosorbide Dinitrate; C030397:isosorbide-5-mononitrate