title: Cardiopulmonary effects of one-lung ventilation in supine patients.
abstract: The cardiopulmonary effects of one-lung ventilation (OLV), with continuous positive airway pressure (CPAP, 5 cm H2O) to the nonventilated lung, were compared to the effects of two-lung ventilation (TLV) in 12 supine patients undergoing coronary artery bypass grafting (CABG). Monitoring was performed with electrocardiography (ECG), arterial, and pulmonary artery catheters. Measurements of cardiac index (CI), heart rate (HR), systemic (MAP) and pulmonary artery pressures (PAP), pulmonary artery occlusion pressure (PAOP), mixed venous oxygen saturation (SvO2), and arterial blood for pH, PaO2, PaCO2 and HCO3- were performed with stable maintenance of anesthesia during both one- and two-lung ventilation. Mean values for CI, HR, MAP, MPAP, PVR, and SvO2 demonstrated no significant changes between OLV and TLV; systemic vascular resistance (SVR) and pulmonary artery occlusion pressure (PAOP) were statistically (P < 0.05) different, but of minor clinical significance. The data suggest that OLV, accompanied by CPAP (5 cm H2O) to the nonventilated lung, produces minimal changes in cardiopulmonary measurements in supine patients.
authors.affiliation: Department of Anesthesiology, Virginia Mason Medical Center, Seattle WA 98111, USA.
authors.forename: H I
authors.initials: HI
authors.lastname: Kashtan
authors.forename: D L
authors.initials: DL
authors.lastname: Brown
mesh_terms: D000328:Adult; D000368:Aged; D001794:Blood Pressure; D005260:Female; D006339:Heart Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D011175:Positive-Pressure Respiration; D011651:Pulmonary Artery / Q000503:physiopathology; D012121:Respiration, Artificial; D016683:Supine Position; D014655:Vascular Resistance
chemical_list: D010100:Oxygen