Coeliac disease and primary hyperparathyroidism: an association?
Primary hyperparathyroidism may present with non-specific symptoms, and this may be one reason why patients with coeliac disease fail to improve despite compliance with a gluten-free diet. Seven case reports of primary hyperparathyroidism due to sporadic adenoma occurring in a series of 310 patients with coeliac disease are presented, highlighting the importance of looking for this condition in this population group. A prevalence of primary hyperparathyroidism of 2.3% in this series suggests a significant association between hyperparathyroidism and coeliac disease; most studies have indicated a prevalence of 3 in 1000 in the general population, although one study found that it may be as high as 21 in 1000 in women aged 55-75 years. The average age of patients in our series was 59 years and all but one were women. Further studies are needed to establish a possible association between primary hyperparathyroidism and coeliac disease.
Maida
M J
MJ
Department of Gastroenterology, Llandough Hospital, Penarth CF64 2XX, UK. mjmaida@doctors.org.uk
Praveen
E
E
Crimmins
S R
SR
Swift
G L
GL
D000236:Adenoma / Q000150:complications*; D000368:Aged; D002446:Celiac Disease / Q000209:etiology*; D005260:Female; D006801:Humans; D049950:Hyperparathyroidism, Primary / Q000150:complications*; D008875:Middle Aged; D010282:Parathyroid Neoplasms / Q000150:complications*