Synthesis of an advanced intermediate en route to the mitomycin natural products.
[Structure: see text] An advanced intermediate in our planned synthesis of mitomycin C has been acquired in nine steps from tert-butyl glyoxylate. The aziridinyl pyrrolidine and quinone subunits are coupled regioselectively to arrive at an enamine that is prepared for C10 homologation.
Williams
Amie L
AL
Department of Chemistry, Vanderbilt University, Nashville, Tennessee 37235-1822, USA.
Srinivasan
Jayasree M
JM
Johnston
Jeffrey N
JN
D001688:Biological Products / Q000138:chemical synthesis*; D016685:Mitomycin / Q000138:chemical synthesis*
D001688:Biological Products; D016685:Mitomycin