[White sponge naevus. Report of a family with respect to histopathologic, cytopathologic and DNA-cytometric aspects].
The white sponge naevus is a rare benign, hereditary autosomal dominant disorder of the mucosa. The oral mucosa is most often affected, but vaginal and anal mucosal surfaces may also be involved. Clinically, a whitish-grey, ragged, and folded surface that has no clear demarcation and appears sponge-like is characteristic, often creating problems in differential diagnosis. A potential risk for malignant transformation of white sponge naevus lesions has not been reported. The therapy for this benign hereditary disorder is unknown, however does not appear to be necessary. In the present report of a family with known white sponge naevus in three different generations, clinical, histopathologic, cytopathologic, DNA-cytomertric, and genetic aspects are described and discussed.
Harnisch
Hendrik
H
Klinik für Oralchirurgie und Stomatologie, Zahnmedizinische Kliniken der Universität Bern.
Paredes
Bruno E
BE
Spieler
Peter
P
Bornstein
Michael M
MM
D000293:Adolescent; D000368:Aged; D000782:Aneuploidy; D003581:Cytodiagnosis; D003937:Diagnosis, Differential; D005192:Family Health; D005260:Female; D006222:Hamartoma / Q000235:genetics* / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa / Q000473:pathology; D010375:Pedigree