Human MutLalpha: the jack of all trades in MMR is also an endonuclease.
Recently, Paul Modrich's group reported the discovery of an intrinsic endonuclease activity for human MutLalpha. This breakthrough provides a satisfactory answer to the longstanding puzzle of a missing nuclease activity in human mismatch repair and will undoubtedly lead to new investigations of DNA repair and replication. Here, the implications of this exciting new finding are discussed in the context of mismatch repair in Escherichia coli and humans.
Yang
Wei
W
Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA. Wei.Yang@nih.gov
D000251:Adenosine Triphosphatases; D053843:DNA Mismatch Repair; D045643:DNA Repair Enzymes; D004720:Endonucleases; D004926:Escherichia coli; D029968:Escherichia coli Proteins; D006801:Humans; D000070956:MutL Proteins; D009363:Neoplasm Proteins
D029968:Escherichia coli Proteins; C074770:MutL protein, E coli; C500929:MutLalpha protein, human; D009363:Neoplasm Proteins; D004720:Endonucleases; D000251:Adenosine Triphosphatases; D000070956:MutL Proteins; D045643:DNA Repair Enzymes