Octaplex formation of d(GCGAAAGC) with the double A-quartet.
We reported that the sequence gcGA[X]1Agc adopts a specific structure to form several multiplexes. In the case of X=G, an octaplex formation occurs, in which the stacked double G-quartet stabilizes the architecture through potassium cation mediations. In the case of a mutant X=A, too, it has been found that the oligomers form an octaplex. The eight central A residues form a stacked double A-quartet, which is a first example of adenine associations. Several water molecules occupy the centre to stabilize the quartets, so that the octaplex seems to be swollen as compared with that of X=G. In any multiplex formations, the building block is a base-intercalated duplexes.
Mitomi
Kenta
K
Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohama, Japan.
Kondo
Jiro
J
Adachi
Wataru
W
Umeda
Shun-ichi
S
Fujita
Kazuhiro
K
Sunami
Tomoko
T
Takénaka
Akio
A
D000225:Adenine / Q000737:chemistry; D001483:Base Sequence; D004247:DNA / Q000737:chemistry*; D054856:G-Quadruplexes; D006147:Guanine / Q000737:chemistry; D018598:Minisatellite Repeats; D008958:Models, Molecular
D006147:Guanine; D004247:DNA; D000225:Adenine