Physical theory of the competition that allows HIV to escape from the immune system.
Competition within the immune system may degrade immune control of viral infections. We formalize the evolution that occurs in both HIV-1 and the immune system quasispecies. Inclusion of competition in the immune system leads to a novel balance between the immune response and HIV-1, in which the eventual outcome is HIV-1 escape rather than control. The analytical model reproduces the three stages of HIV-1 infection. We propose a vaccine regimen that may be able to reduce competition between T cells, potentially eliminating the third stage of HIV-1.
Wang
Guanyu
G
Department of Bioengineering and Department of Physics and Astronomy, Rice University, Houston, Texas 77005-1892, USA.
Deem
Michael W
MW
D005075:Biological Evolution; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D007107:Immune System / Q000821:virology*; D018448:Models, Immunological