title: [Relationship between quinone oxidoreductase1 gene ns-cSNP and genetic susceptibility of esophageal cancer].
abstract: OBJECTIVE
  To explore the relationship between quinone oxidoreductase1 (NQO1) gene nonsynonymous cSNP and the genetic susceptibility of esophageal cancer.
  
  
  METHODS
  Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and Allele-Specific PCR (AS-PCR) were employed to assess the polymorphism of NQO1 genes both in 106 patients with esophageal cancer and control subjects matched by age, gender and origin.
  
  
  RESULTS
  It was shown that no C/C genotype was found at 406 of NQO1. The allelic frequency of NQO1 609T was significantly higher in patients with esophageal cancer than in the control subjects (P < 0.005) and the individuals with 609T allelic genotype of NQO1 gene were at greater risk to develop esophageal cancer (OR = 4.76, 95% CI = 1.064 - 3.397). But Individuals with mutant allele of NQO1 465 genotype did not show the rising risk of esophageal cancer.
  
  
  CONCLUSIONS
  The NQO1 C609T polymorphisms should likely be associated with the genetic susceptibility of esophageal cancer.
authors.affiliation: School of Public Health, Southeast University, Nanjing 210009, China.
authors.forename: Wen-cui
authors.initials: WC
authors.lastname: Zhang
authors.forename: Li-hong
authors.initials: LH
authors.lastname: Yin
authors.forename: Yue-pu
authors.initials: YP
authors.lastname: Pu
authors.forename: Ge-yu
authors.initials: GY
authors.lastname: Liang
authors.forename: Xu
authors.initials: X
authors.lastname: Hu
authors.forename: Yao-zhen
authors.initials: YZ
authors.lastname: Liu
authors.forename: Yong-sheng
authors.initials: YS
authors.lastname: Cui
mesh_terms: D000483:Alleles; D002681:China; D004938:Esophageal Neoplasms / Q000208:ethnology / Q000235:genetics*; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D016660:NAD(P)H Dehydrogenase (Quinone) / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
chemical_list: D016660:NAD(P)H Dehydrogenase (Quinone); C447479:NQO1 protein, human