title: Influence of acute exercise on hyperglycemia in insulin-treated type 2 diabetes.
abstract: BACKGROUND
  The impact of exercise on blood glucose homeostasis has not been assessed in long-standing type 2 diabetes patients receiving exogenous insulin treatment.
  
  
  OBJECTIVE
  To study the effects of an acute bout of exercise on the subsequent 24-h blood glucose excursions under free-living conditions in insulin-treated type 2 diabetes patients.
  
  
  METHODS
  Eleven male type 2 diabetes patients (59 +/- 2 yr) performed an acute bout of exercise. One day before the exercise bout, a continuous glucose monitoring system (GlucoDay, A. Menarini Diagnostics) was inserted subcutaneously in the periumbilical region. The glucose sensor continuously measured glucose concentrations in the dialysate during a 48-h period.
  
  
  RESULTS
  The prevalence of hyperglycemic glucose excursions was reduced by 39% during a 24-h period (equivalent to 3 h) after an acute bout of exercise (P < 0.05). Average glucose concentrations 24 h before and after the exercise bout did not differ (NS). Mean dialysate glucose concentrations and the prevalence of hyperglycemic periods correlated strongly with baseline blood HbA1c concentrations (Pearson's R = 0.69, P < 0.05).
  
  
  CONCLUSIONS
  An acute bout of exercise effectively reduces the prevalence of hyperglycemia during a 24-h period under free-living conditions in long-standing type 2 diabetes patients on exogenous insulin therapy.
authors.affiliation: Department of Movement Sciences, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands. S.Praet@mmc.nl
authors.forename: Stephan F
authors.initials: SF
authors.lastname: Praet
authors.forename: Ralph J
authors.initials: RJ
authors.lastname: Manders
authors.forename: A G
authors.initials: AG
authors.lastname: Lieverse
authors.forename: Harm
authors.initials: H
authors.lastname: Kuipers
authors.forename: Coen D
authors.initials: CD
authors.lastname: Stehouwer
authors.forename: Hans A
authors.initials: HA
authors.lastname: Keizer
authors.forename: Luc J
authors.initials: LJ
authors.lastname: van Loon
mesh_terms: D000368:Aged; D001786:Blood Glucose / Q000032:analysis; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000188:drug therapy*; D015444:Exercise; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D006943:Hyperglycemia / Q000097:blood / Q000517:prevention & control*; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D007328:Insulin / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D018670:Monitoring, Ambulatory; D010807:Physical Endurance
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin; D007004:Hypoglycemic Agents; D007328:Insulin