title: [FTIR spectroscopic characterization of freshly removed breast cancer tissues].
abstract: OBJECTIVE
  To identify the FTIR spectroscopic characterization of breast cancer and explore the possibility of application of FTIR in differentiation of malignant and benign breast lesions.
  
  
  METHODS
  FTIR spectra of surgically removed fresh breast tissues were measured by spectrometer equipped with mid-infrared fiber optics and an ATR probe. Peaks in the spectra were measured and relative intensity ratios were calculated and analyzed if there are significant differences between the spectra of malignant and benign breast lesions.
  
  
  RESULTS
  There were significant differences (P < 0.05) between the spectra of malignant breast cancers and benign breast tissues in the relative intensity ratios of different peaks (I1640/ I1550 and I1160/I1120 for protein structures; I1640/I1460 and I1550/I1460 for relative content of protein and lipid; I1460/I1400 for lipid structures; I1310/I1240 for nucleic acid).
  
  
  CONCLUSIONS
  FTIR spectroscopy could be a useful tool in clinical diagnosis of breast cancer.
authors.affiliation: Department of General Surgery, Third Hospital of Peking University, Beijing 100083, China.
authors.forename: Su
authors.initials: S
authors.lastname: Zhou
authors.forename: Zhi
authors.initials: Z
authors.lastname: Xu
authors.forename: Xiao-Feng
authors.initials: XF
authors.lastname: Ling
authors.forename: Qing-Bo
authors.initials: QB
authors.lastname: Li
authors.forename: Yi-Zhuang
authors.initials: YZ
authors.lastname: Xu
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.forename: Hong-Mei
authors.initials: HM
authors.lastname: Zhao
authors.forename: Li-Xin
authors.initials: LX
authors.lastname: Wang
authors.forename: Kuan-Yong
authors.initials: KY
authors.lastname: Hou
authors.forename: Xiao-Si
authors.initials: XS
authors.lastname: Zhou
authors.forename: Jin-Guang
authors.initials: JG
authors.lastname: Wu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001940:Breast / Q000737:chemistry / Q000473:pathology; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000378:metabolism; D018270:Carcinoma, Ductal, Breast / Q000175:diagnosis* / Q000378:metabolism; D005260:Female; D018226:Fibroadenoma / Q000175:diagnosis* / Q000378:metabolism; D006801:Humans; D008055:Lipids / Q000032:analysis; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000032:analysis; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D017550:Spectroscopy, Fourier Transform Infrared / Q000379:methods*
chemical_list: D008055:Lipids; D009363:Neoplasm Proteins