title: Carbohydrate-based scaffolds in drug discovery.
abstract: Carbohydrates have been proven as valuable scaffolds to display pharmocophores and the resulting molecules have demonstrated useful biological activity towards various targets including the somatostatin receptors (SSTR), integrins, HIV-1 protease, matrix metalloproteinases (MMP), multidrug resistance-associated protein (MRP), and as RNA binders. Carbohydrate-based compounds have also shown antibacterial and herbicidal activity.
authors.affiliation: Alchemia Ltd, PO Box 6242, Upper Mt Gravatt, Qld 4122, Australia. bbecker@alchemia.com.au
authors.forename: Bernd
authors.initials: B
authors.lastname: Becker
authors.forename: Glenn C
authors.initials: GC
authors.lastname: Condie
authors.forename: Giang Thanh
authors.initials: GT
authors.lastname: Le
authors.forename: Wim
authors.initials: W
authors.lastname: Meutermans
mesh_terms: D002241:Carbohydrates / Q000737:chemistry*; D015195:Drug Design
chemical_list: D002241:Carbohydrates