Elevated plasma concentrations of the endogenous nitric oxide synthase inhibitor asymmetric dimethylarginine in citrullinemia.
Citrullinemia is an inborn error of the urea cycle with deficiency of the argininosuccinate synthase. It is characterized by elevated concentrations of l-citrulline and decreased levels of l-arginine in body fluids. Asymmetric dimethylarginine is an endogenous inhibitor of nitric oxide synthase that converts l-arginine to l-citrulline and nitric oxide (NO). Asymmetric dimethylarginine is hydrolyzed by the enzyme dimethylarginine dimethylaminohydrolase to l-citrulline and dimethylamine. Elevation of l-citrulline in citrullinemia prompted us to study the l-arginine/NO pathway in this disorder. In 8 children with citrullinemia (3 days to 3 years of age), elevated plasma levels of asymmetric dimethylarginine (P = .028) were found compared with age-matched healthy children. We hypothesize that the l-arginine/NO pathway plays a role in the pathophysiology of citrullinemia.
Lücke
Thomas
T
Department of Pediatrics, Medical School of Hannover, Carl Neuberg Str. 1, D-30625 Hannover, Germany. luecke.thomas@mh-hannover.de
Tsikas
Dimitrios
D
Kanzelmeyer
Nele
N
Vaske
Bernhard
B
Das
Anibh Martin
AM
D001120:Arginine / Q000031:analogs & derivatives* / Q000097:blood / Q000502:physiology / Q000652:urine; D020159:Citrullinemia / Q000097:blood* / Q000209:etiology; D004791:Enzyme Inhibitors / Q000097:blood*; D006801:Humans; D009569:Nitric Oxide / Q000502:physiology; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors*
D004791:Enzyme Inhibitors; D009569:Nitric Oxide; C018524:N,N-dimethylarginine; D001120:Arginine; D019001:Nitric Oxide Synthase