title: From autophagic to necrotic cell death in Dictyostelium.
abstract: Among unusual models to study cell death mechanisms, the protist Dictyostelium is remarkable because of its strategic phylogenetic position, with early emergence among eukaryotes and unicellular/multicellular transition, and its very favorable experimental and genetic flexibility. Dictyostelium shows developmental vacuolar cell death, and in vitro monolayer approaches revealed both an autophagic vacuolar and a necrotic type of cell death. These are described in some detail, as well as implications and future prospects.
authors.affiliation: Centre d'Immunologie de Marseille-Luminy, Université de la Méditerranée, Case 906, 13288 Marseille Cedex 9, France.
authors.forename: Emilie
authors.initials: E
authors.lastname: Tresse
authors.forename: Artemis
authors.initials: A
authors.lastname: Kosta
authors.forename: Marie-Françoise
authors.initials: MF
authors.lastname: Luciani
authors.forename: Pierre
authors.initials: P
authors.lastname: Golstein
mesh_terms: D000818:Animals; D001343:Autophagy; D016923:Cell Death; D004023:Dictyostelium / Q000502:physiology*; D009336:Necrosis