title: Decreased chemiluminescence in leukocyte adhesion deficiency presenting with recurrent sepsis, amoebiasis and Candida albicans urinary tract infection.
abstract: Leukocyte adhesion deficiency (LAD) is a rare disorder of cellular immunity, generally due to various mutations producing reduced or altered expression of membrane integrins. The authors report a case of LAD due to integrins expression imbalance. LAD was suspected after recurrent sepsis, fungal infection and amoebiasis with persistent leukocytosis. Neutrophils were studied with chemiluminescence showing decreased functional activity: up to now, this seems the first chemiluminescence study of neutrophil function and the first report of amoebiasis at the onset in LAD.
authors.affiliation: Pediatric Infectious Disease Unit, Department of Pediatrics, Sacro Cuore Catholic University, Rome, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Valentini
authors.forename: P
authors.initials: P
authors.lastname: De Sole
authors.forename: D
authors.initials: D
authors.lastname: De Luca
authors.forename: P
authors.initials: P
authors.lastname: Plaisant
authors.forename: P
authors.initials: P
authors.lastname: Puggioni
authors.forename: M C
authors.initials: MC
authors.lastname: Rossi
authors.forename: C
authors.initials: C
authors.lastname: Rumi
authors.forename: O
authors.initials: O
authors.lastname: Ranno
mesh_terms: D000818:Animals; D040881:CD11a Antigen / Q000032:analysis*; D039481:CD11b Antigen / Q000032:analysis*; D002177:Candidiasis / Q000188:drug therapy / Q000276:immunology; D004748:Entamoeba histolytica / Q000302:isolation & purification; D004749:Entamoebiasis / Q000276:immunology; D005260:Female; D006801:Humans; D007223:Infant; D018370:Leukocyte-Adhesion Deficiency Syndrome / Q000276:immunology*; D007964:Leukocytosis / Q000276:immunology; D049449:Luminescence; D009504:Neutrophils / Q000276:immunology; D012008:Recurrence; D018805:Sepsis / Q000188:drug therapy / Q000276:immunology; D014552:Urinary Tract Infections / Q000276:immunology / Q000382:microbiology
chemical_list: D040881:CD11a Antigen; D039481:CD11b Antigen