title: [Osteonecrosis associated with the use of biphosphonates: Case report].
abstract: Biphosphonates reduce the risk of skeletal events and are currently part of standards of therapy in myeloma. Recently, zoledronate and pamidronate have been linked to osteonecrosis of the jaw, specially after surgical dental procedures. We report a 84 year-old man with multiple myeloma who developed spontaneous osteonecrosis of both jaws, after 36 months of therapy with zoledronate with a cumulative dose of 136 mg. We discuss the pathogenic mechanisms, and review the recommendations on prevention and management of this new complication for neoplastic patients under prolonged therapy with biphosphonates.
authors.affiliation: Departamento de Oncohematología, Clínica Alemana de Santiago, Chile. tanguita@alemana.cl
authors.forename: Timoleón
authors.initials: T
authors.lastname: Anguita C
authors.forename: Jaime
authors.initials: J
authors.lastname: Agurto P
authors.forename: Iván
authors.initials: I
authors.lastname: Roa E
authors.forename: German
authors.initials: G
authors.lastname: Laissle C
mesh_terms: D000369:Aged, 80 and over; D050071:Bone Density Conservation Agents / Q000009:adverse effects*; D004164:Diphosphonates / Q000009:adverse effects*; D006801:Humans; D007093:Imidazoles / Q000009:adverse effects*; D007571:Jaw Diseases / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D009101:Multiple Myeloma / Q000188:drug therapy*; D010020:Osteonecrosis / Q000139:chemically induced* / Q000473:pathology; D000077268:Pamidronate; D000077211:Zoledronic Acid
chemical_list: D050071:Bone Density Conservation Agents; D004164:Diphosphonates; D007093:Imidazoles; D000077211:Zoledronic Acid; D000077268:Pamidronate