A new sesquiterpene ester inhibiting no production from the fruits of Celastrus orbiculatus.
A new beta-dihydroagarofuran sesquiterpene ester, 1beta,2beta,6alpha, 13-tetraacetoxy-9alpha-cinnamoyloxy-beta-dihydroagarofuran (1), and the known compound 1beta,6alpha,13-triacetoxy-9alpha-benzoyloxy-beta-dihydroagarofuran (2), have been isolated from the fruits of Celastrus orbiculatus Thunb. Their structures have been elucidated on the basis of spectroscopic methods. Compound 1 shows moderate activity of inhibiting LPS-induced nitric oxide production in murine macrophage RAW264.7 cells, with an IC50 of 55.4 microM.
Guo
Y-Q
YQ
Research Department of Natural Medicine, Shenyang Pharmaceutical University, Shenyang, 110016, China.
Li
X
X
Lee
J-J
JJ
Xu
J
J
Li
N
N
Meng
D-L
DL
Wang
J-H
JH
D000818:Animals; D031247:Celastrus / Q000737:chemistry*; D002460:Cell Line; D002681:China; D002851:Chromatography, High Pressure Liquid; D004952:Esters / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D005638:Fruit / Q000737:chemistry*; D005663:Furans / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D015394:Molecular Structure; D009569:Nitric Oxide / Q000037:antagonists & inhibitors; D010946:Plants, Medicinal / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
C517954:1beta,2beta,6alpha, 13-tetraacetoxy-9alpha-cinnamoyloxy-beta-dihydroagarofuran; D004952:Esters; D005663:Furans; D012717:Sesquiterpenes; D009569:Nitric Oxide