title: Ion-channel sensors based on ETH 1001 ionophore embedded in charged-alkanethiol self-assembled monolayers on gold electrode surfaces.
abstract: An ion-channel sensor was demonstrated by immobilizing ETH 1001, an ionophore for ion-selective electrodes, on a gold electrode surface. The approach for preparing the sensor was to incorporate the ionophore into a mixed self-assembled monolayer of 10-mercaptodecanesulfonate and 11-hydroxy-1-undecanethiol formed on the surface. The voltammetric responses for the thus prepared sensor to the primary cation Ca(2+) were observed by using [Fe(CN)(6)](3-/4-) as an electroactive marker. The ionophore was stably immobilized on the electrode surface with the hydrophobic interaction between its alkyl chains and those of the alkanethiol. The introduction of a proper charge density to the electrode surface improved the sensor sensitivity with retaining the selective response to Ca(2+) against Mg(2+) with concentrations above 10(-4) M.
authors.affiliation: Department of Chemistry, School of Science, The University of Tokyo, Japan. aoki-h@aist.go.jp
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Aoki
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Umezawa
authors.forename: Alberto
authors.initials: A
authors.lastname: Vertova
authors.forename: Sandra
authors.initials: S
authors.lastname: Rondinini