Hepatoprotective effect of fetal tissue cytosol and its thermostable fraction in rats with carbon tetrachloride-induced hepatitis.
Pretreatment of rats with cytosol of fetal tissue or its thermostable fraction prevented death of animals from CCl4 intoxication, decreased serum transaminase activities and level of TBA-reactive products, and normalized the prooxidant/antioxidant balance in the liver. The effect of cytosol was more pronounced than that of its thermostable fraction.
Cherkashina
D V
DV
Institute of Cryobiology and Cryomedicine Problems, National Academy of Sciences of Ukraine, Kharkov. danusha@ukr.net
Petrenko
A Yu
AY
D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D002251:Carbon Tetrachloride / Q000633:toxicity; D002252:Carbon Tetrachloride Poisoning / Q000628:therapy*; D003600:Cytosol / Q000378:metabolism*; D004622:Embryo, Mammalian / Q000378:metabolism; D006505:Hepatitis / Q000378:metabolism / Q000628:therapy*; D006801:Humans; D008099:Liver / Q000187:drug effects*; D008297:Male; D016877:Oxidants / Q000378:metabolism; D051381:Rats
D000975:Antioxidants; D016877:Oxidants; D002251:Carbon Tetrachloride