title: [Obesity, diabetes and insulin resistance. Alterations of insulin signalling].
abstract: Obesity is often associated with diabetes and insulin resistance. This review summarizes evidence obtained in our lab on the role of the serine phosphorylation of the insulin receptor substrate 1 in the down regulation of insulin signalling. The role of the ERK1 isoform in the development of adipose tissue and insulin sensitivity is also presented.
authors.affiliation: INSERM, U568, Faculté de Mèdecine, Université de Nice Sophia Antipolis, Avenue de Valombrose, 06107 Nice 02, France. lemarcha@unice.fr
authors.forename: Yannick
authors.initials: Y
authors.lastname: Le Marchand-Brustel
authors.forename: Philippe
authors.initials: P
authors.lastname: Gual
authors.forename: Myriam
authors.initials: M
authors.lastname: Aouadi
authors.forename: Thierry
authors.initials: T
authors.lastname: Grémeaux
authors.forename: Bernard
authors.initials: B
authors.lastname: Binétruy
authors.forename: Frédéric
authors.initials: F
authors.lastname: Bost
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Tanti
mesh_terms: D000273:Adipose Tissue / Q000502:physiology / Q000503:physiopathology; D003920:Diabetes Mellitus / Q000503:physiopathology*; D006801:Humans; D007328:Insulin / Q000502:physiology*; D055504:Insulin Receptor Substrate Proteins; D007333:Insulin Resistance / Q000502:physiology*; D048052:Mitogen-Activated Protein Kinase 3 / Q000378:metabolism; D009765:Obesity / Q000503:physiopathology*; D010750:Phosphoproteins / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*
chemical_list: C526292:IRS1 protein, human; D007328:Insulin; D055504:Insulin Receptor Substrate Proteins; D010750:Phosphoproteins; D048052:Mitogen-Activated Protein Kinase 3