[The morphologic variants of KSHV/HHV 8-associated lymphoproliferations].
KSHV/HHV 8 infection is associated with primary effusion lymphoma, multicentric Castleman disease (MCD) and MCD-associated plasmablastic lymphoma. We report the case of an HIV-infected male with Kaposi sarcoma, MCD in the lymph node and development of a KSHV/HHV 8-associated plasmablastic lymphoma in the liver. Immunohistochemistry revealed an HHV 8 infection of plasmablasts showing cytoplasmic IgM/lambda expression. To the best of our knowledge, liver infiltration by a MCD-associated HHV 8 positive plasmablastic lymphoma has not been documented previously. The differential diagnosis is discussed.
Loddenkemper
C
C
Institut für Pathologie, Konsultations- und Referenzzentrum für Lymphknoten- und Hämatopathologie, Charité-Universitätsmedizin Berlin, Campus Benjamin Franklin, Berlin. christoph.loddenkemper@charite.de
Longerich
T
T
Schneider
T
T
Anagnostopoulos
I
I
Foss
H D
HD
Schirmacher
P
P
Stein
H
H
D000328:Adult; D014644:Genetic Variation; D006679:HIV Seropositivity; D019288:Herpesvirus 8, Human / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology / Q000556:secondary; D008207:Lymphatic Metastasis; D008232:Lymphoproliferative Disorders / Q000473:pathology* / Q000821:virology*; D008297:Male; D009362:Neoplasm Metastasis; D012514:Sarcoma, Kaposi / Q000473:pathology*