title: Role of selective arterial secretin injection test in treatment of gastrinoma.
abstract: OBJECTIVE
  To study whether use of the selective arterial secretin injection test increased the rate of tumor localization and curative resection in patients with gastrinoma.
  
  
  METHODS
  Nine patients with gastrinoma were divided into 2 groups, before and after introduction of selective arterial secretin injection test; 4 patients before 1987 (Group 1) and 5 patients after 1988 (Group 2). Clinical results were compared retrospectively between groups.
  
  
  RESULTS
  Localization of primary gastrinoma was made with conventional imaging studies in 1 of the 4 patients in Group 1 and 3 of the 5 patients in Group 2. In contrast, use of the selective arterial secretin injection test was able to localize the primary tumor in 4 of the 5 patients in Group 2. Total gastrectomy was carried out in the 4 patients in Group 1, and pancreatoduodenectomy was the most frequently performed procedure (3 patients) in Group 2. Rate of curative resection was 25% and 80% in Groups 1 and 2, respectively.
  
  
  CONCLUSIONS
  These results indicate that combining selective arterial secretin injection test with conventional imaging studies contributes to increasing rate of curative resection of gastrinoma.
authors.affiliation: Division of Biological Regulation and Oncology, Tohoku University Graduate School of Medicine, Sendai, Japan. cshibata@gonryo.med.tohoku.ac.jp
authors.forename: Chikashi
authors.initials: C
authors.lastname: Shibata
authors.forename: Yuji
authors.initials: Y
authors.lastname: Funayama
authors.forename: Kouhei
authors.initials: K
authors.lastname: Fukushima
authors.forename: Ken-Ichi
authors.initials: K
authors.lastname: Takahashi
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Ueno
authors.forename: Munenori
authors.initials: M
authors.lastname: Nagao
authors.forename: Sho
authors.initials: S
authors.lastname: Haneda
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Watanabe
authors.forename: Katsuyoshi
authors.initials: K
authors.lastname: Kudoh
authors.forename: Atsushi
authors.initials: A
authors.lastname: Kohyama
authors.forename: Hiroo
authors.initials: H
authors.lastname: Naito
authors.forename: Iwao
authors.initials: I
authors.lastname: Sasaki
mesh_terms: D000328:Adult; D003952:Diagnostic Imaging; D005260:Female; D015408:Gastrinoma / Q000175:diagnosis* / Q000601:surgery*; D006801:Humans; D007269:Injections, Intra-Arterial; D008297:Male; D008875:Middle Aged; D010186:Pancreatic Function Tests; D010190:Pancreatic Neoplasms / Q000175:diagnosis* / Q000601:surgery*; D011379:Prognosis; D012633:Secretin / Q000008:administration & dosage; D016896:Treatment Outcome
chemical_list: D012633:Secretin