title: Reactivation of hepatitis in a bladder cancer patient receiving chemotherapy.
abstract: Reactivation of hepatitis is a serious complication of chemotherapy in hepatitis B virus (HBV) carriers. There are many reports of this in lymphoma patients but few in urological cancer patients. A 59-year-old woman with bladder cancer who was an HBV carrier developed severe liver dysfunction after 2 cycles of chemotherapy. The diagnosis was reactivation of hepatitis. She improved with administration of lamivudine with a steroid and is currently well without disease. Care should be taken about the risk of reactivation when performing chemotherapy in HBV carriers and prophylaxis by lamivudine should be considered.
authors.affiliation: Department of Renal and Genito-urinary Surgery, Graduate School of Medicine, Hokkaido University, Kita-15, Nishi-7, Sapporo, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Higashiyama
authors.forename: Toru
authors.initials: T
authors.lastname: Harabayashi
authors.forename: Nobuo
authors.initials: N
authors.lastname: Shinohara
authors.forename: Makoto
authors.initials: M
authors.lastname: Chuma
authors.forename: Shuhei
authors.initials: S
authors.lastname: Hige
authors.forename: Katsuya
authors.initials: K
authors.lastname: Nonomura
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects*; D002945:Cisplatin / Q000009:adverse effects*; D015251:Epirubicin / Q000009:adverse effects*; D005260:Female; D006509:Hepatitis B / Q000139:chemically induced*; D006801:Humans; D008727:Methotrexate / Q000009:adverse effects*; D008875:Middle Aged; D012008:Recurrence; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy*
chemical_list: D000970:Antineoplastic Agents; D015251:Epirubicin; D002945:Cisplatin; D008727:Methotrexate