Effects of Helicobacter pylori infection on gut appetite peptide (leptin, ghrelin) expression in elderly inpatients.
The aim of the study was to investigate the relationship between gastritis and leptin and ghrelin in elderly patients. Patients older than 75 years undergoing an endoscopy were included. We reported data on nutritional status and Helicobacter pylori infection diagnosis (serology, 13C-urea breath test, culture, histology, and polymerase chain reaction on gastric biopsies). Gastric messenger RNA expression of leptin and ghrelin were quantified by real-time polymerase chain reaction. Sixty-two patients were included (84.7 +/- 5.2 years). H. pylori infection was associated with decreased gastric expression of leptin (p = .021), ghrelin (p =.002), and plasma ghrelin levels (p = .018). Atrophy was associated with decreased gastric leptin (p = .007) and ghrelin (p = .02). H. pylori infection correlated negatively with patient energy intake (r = -0.36; p = .001) and body mass index (r = -0.34; p = .018). The negative association between ghrelin and H. pylori infection may be related to a higher prevalence of atrophy and raises the possibility that H. pylori may be contributing to undernutrition in some older people.
Salles
Nathalie
N
INSERM ERI 10, Laboratoire de Bactériologie, Université Victor Segalen Bordeaux 2, Bât 2B RDC Zone Nord, 33076 Bordeaux cedex, France. nathalie.salles@chu-bordeaux.fr
Ménard
Armelle
A
Georges
Agnès
A
Salzmann
Mélanie
M
de Ledinghen
Victor
V
de Mascarel
Antoine
A
Emeriau
Jean-Paul
JP
Lamouliatte
Hervé
H
Mégraud
Francis
F
D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000378:metabolism; D015992:Body Mass Index; D016099:Endoscopy, Gastrointestinal; D002149:Energy Intake / Q000502:physiology; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism; D005757:Gastritis, Atrophic / Q000378:metabolism; D054439:Ghrelin; D016481:Helicobacter Infections / Q000378:metabolism*; D016480:Helicobacter pylori; D006801:Humans; D020738:Leptin / Q000235:genetics / Q000378:metabolism*; D008297:Male; D009752:Nutritional Status; D036361:Peptide Hormones / Q000235:genetics / Q000378:metabolism*; D016133:Polymerase Chain Reaction; D012333:RNA, Messenger / Q000378:metabolism; D012720:Severity of Illness Index; D013270:Stomach / Q000473:pathology
D054439:Ghrelin; D020738:Leptin; D036361:Peptide Hormones; D012333:RNA, Messenger