Asymmetric cooperativity in tandem hybridization of the DNA conjugates bearing chiral metal complexes.
Each of the enantiomers of [Ru(phen)2(dppz)]2+ (phen = 1,10-phenanthroline, dppz = dipyrido[3,2-a:2',3'-c]phenazine) complex was attached to the 5' end of the short oligonucleotide to form a pair of the conjugates. The delta-isomer of them showed a high cooperativity in tandem hybridization to the repetitive sequence, while the lambda-isomer did not.
Ihara
Toshihiro
T
Department of Applied Chemistry and Biochemistry, Faculty of Engineering, Kumamoto University, 2-39-1 Kurokami, Kumamoto 860-8555, Japan.
Kitamura
Yusuke
Y
Okada
Kenji
K
Tazaki
Masato
M
Jyo
Akinori
A
D015342:DNA Probes / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000737:chemistry*; D009838:Oligodeoxyribonucleotides / Q000737:chemistry; D009942:Organometallic Compounds / Q000737:chemistry*; D012091:Repetitive Sequences, Nucleic Acid; D013237:Stereoisomerism; D016615:Telomere / Q000737:chemistry
D015342:DNA Probes; D005456:Fluorescent Dyes; D009838:Oligodeoxyribonucleotides; D009942:Organometallic Compounds; C466600:Ru(phen)(2)dipyrido(3,2-a-2',3'-c)phenazine