Weighing in on fistula failure.
Obesity, though not commonly reported as a cause of fistula failure, may influence fistula survival by making it difficult to cannulate the vein and possibly by releasing adipokines, such as interleukin-6, tumor necrosis factor-alpha, plasminogen activator inhibitor-1, or adiponectin, that modulate the development of neointimal hyperplasia and thrombosis leading to fistula failure.
Dixon
B S
BS
Veterans Affairs Medical Center, Nephrology Division, University of Iowa School of Medicine, Iowa City, Iowa 52242-1081, USA. bradley-dixon@uiowa.edu
D001158:Arteries / Q000473:pathology; D001166:Arteriovenous Shunt, Surgical / Q000009:adverse effects*; D006801:Humans; D006965:Hyperplasia; D007676:Kidney Failure, Chronic / Q000150:complications / Q000628:therapy; D009765:Obesity / Q000150:complications; D006435:Renal Dialysis / Q000009:adverse effects; D017211:Treatment Failure; D014680:Veins / Q000473:pathology