Basic Science for the clinician 41: tails of cytokine receptor activation and control: JAKs, STATs, PIASs, and SOCSs.
We now have an emerging sense of the details of how cytokines deliver their signals through the specific receptors to which they bind and the means by which these messages are modulated. Using common mechanisms, many of which have been described in past articles in this series, tight controls are maintained over this signaling. A better understanding of the molecular details of these pathways has provided insights into the pathogenesis of some malignancies and immunodeficiency syndromes and may ultimately yield therapeutic agents of use in the treatment of inflammatory and autoimmune diseases.
Sigal
Leonard H
LH
Pharmaceutical Research Institute, Bristol-Myers Squibb, Princeton, NJ 08543-4000, USA. leonard.sigal@bms.com
D000818:Animals; D053612:Janus Kinases / Q000378:metabolism*; D050828:Protein Inhibitors of Activated STAT / Q000378:metabolism*; D018121:Receptors, Cytokine / Q000378:metabolism*; D050791:STAT Transcription Factors / Q000378:metabolism*; D015398:Signal Transduction; D050826:Suppressor of Cytokine Signaling Proteins / Q000378:metabolism*; D018909:src Homology Domains
D050828:Protein Inhibitors of Activated STAT; D018121:Receptors, Cytokine; D050791:STAT Transcription Factors; D050826:Suppressor of Cytokine Signaling Proteins; D053612:Janus Kinases