Three coexisting lymphomas in one patient: genetically related or only a coincidence?
The simultaneous manifestation of different lymphomas in the same patient or even in the same tissue, defined as composite lymphoma, is very rare. The exceptional case of a patient who, presented with simultaneous manifestation of three different lymphomas after 30 years of successful treatment of a nodal T cell lymphoma is reported here. The three lymphomas were: (1) primary cutaneous marginal zone B cell lymphoma (MZBL); (2) nodal Epstein-Barr virus (EBV)-associated classic Hodgkin's lymphoma (cHL) of the B cell type; and (3) peripheral T cell lymphoma coexisting in the skin and cervical lymph node. Immunohistochemical and molecular analyses showed different clonal origins of EBV-negative cutaneous MZBL and EBV-positive B cell cHL and, in addition, the presence of the same clonal T cell population in the skin and lymph node. The simultaneous occurrence of three different, clonally unrelated lymphomas in one patient at the same time has not been reported yet.
Steinhoff
M
M
Department of Dermatology and Allergy, Charité-Universitaetsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany. matthias.steinhoff@charite.de
Assaf
C
C
Anagnostopoulos
I
I
Geilen
C C
CC
Stein
H
H
Hummel
M
M
D000368:Aged; D020031:Epstein-Barr Virus Infections / Q000150:complications; D005260:Female; D006689:Hodgkin Disease / Q000235:genetics / Q000276:immunology / Q000473:pathology / Q000821:virology; D006801:Humans; D016130:Immunophenotyping; D008223:Lymphoma / Q000235:genetics / Q000276:immunology / Q000473:pathology*; D016393:Lymphoma, B-Cell / Q000235:genetics / Q000276:immunology / Q000473:pathology; D016411:Lymphoma, T-Cell, Peripheral / Q000235:genetics / Q000276:immunology / Q000473:pathology; D009378:Neoplasms, Multiple Primary / Q000235:genetics / Q000276:immunology / Q000473:pathology*; D012878:Skin Neoplasms / Q000235:genetics / Q000276:immunology / Q000473:pathology