Sirtuins as potential targets for metabolic syndrome.
Metabolic syndrome threatens health gains made during the past century. Physiological processes degraded by this syndrome are often oppositely affected by calorie restriction, which extends lifespan and prevents disease in rodents. Recent research in the field of ageing has begun to identify important mediators of calorie restriction, offering the hope of new drugs to improve healthspan. Moreover, if metabolic syndrome and calorie restriction are opposite extremes of the same metabolic spectrum, calorie restriction mimetics might provide another therapeutic approach to metabolic syndrome. Sirtuins and other important metabolic pathways that affect calorie restriction may serve as entry points for drugs to treat metabolic syndrome.
Guarente
Leonard
L
Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA. leng@mit.edu
D055372:AMP-Activated Protein Kinases; D000818:Animals; D031204:Caloric Restriction; D006801:Humans; D024821:Metabolic Syndrome / Q000378:metabolism*; D008928:Mitochondria / Q000378:metabolism; D009097:Multienzyme Complexes / Q000378:metabolism; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism; D037761:Sirtuins / Q000378:metabolism*; D014157:Transcription Factors / Q000378:metabolism
D009097:Multienzyme Complexes; D014157:Transcription Factors; C111264:peroxisome-proliferator-activated receptor-gamma coactivator-1; D017346:Protein Serine-Threonine Kinases; D055372:AMP-Activated Protein Kinases; D037761:Sirtuins