Dietary anthocyanin-rich tart cherry extract inhibits intestinal tumorigenesis in APC(Min) mice fed suboptimal levels of sulindac.
A promising approach for cancer chemoprevention might be a combination therapy utilizing dietary phytochemicals and anticarcinogenic pharmaceuticals at a suboptimal dosage to minimize any potential adverse side effects. To test this hypothesis, various dosages of anthocyanin-rich tart cherry extract were fed in combination with suboptimal levels of the nonsteroidal anti-inflammatory drug sulindac to APCMin mice for 19 weeks. By the end of the feeding period, fewer mice that were fed the anthocyanin-rich extract in combination with sulindac lost more than 10% of body weight than mice fed sulindac alone. Mice that were fed anthocyanin-rich extract (at any dose) in combination with sulindac had fewer tumors and a smaller total tumor burden (total tumor area per mouse) in the small intestine when compared to mice fed sulindac alone. These results suggest that a dietary combination of tart cherry anthocyanins and sulindac is more protective against colon cancer than sulindac alone.
Bobe
Gerd
G
Department of Food Science and Human Nutrition, Bioactive Natural Products and Phytoceuticals, Department of Horticulture, and National Food Safety and Toxicology Center, Michigan State University, East Lansing, MI 44824, USA.
Wang
Bing
B
Seeram
Navindra P
NP
Nair
Muraleedharan G
MG
Bourquin
Leslie D
LD
D011125:Adenomatous Polyposis Coli / Q000235:genetics; D000818:Animals; D000872:Anthocyanins / Q000008:administration & dosage* / Q000032:analysis; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D004032:Diet; D005260:Female; D005638:Fruit / Q000737:chemistry*; D007414:Intestinal Neoplasms / Q000235:genetics / Q000517:prevention & control*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008817:Mice, Mutant Strains; D009154:Mutation; D010936:Plant Extracts / Q000008:administration & dosage / Q000737:chemistry; D027861:Prunus / Q000737:chemistry*; D013467:Sulindac / Q000008:administration & dosage*
D000872:Anthocyanins; D000970:Antineoplastic Agents; D010936:Plant Extracts; D013467:Sulindac