[The growth constraining diet causes various strategy of adaptation in young and adult animals].
The glucose-6-phosphatase activity of microsomes and phosphorylative mitochondrial activity of liver cells, alanine- and aspartate aminotransferase activities in plasma of blood of young (3 month) and adult (21 month) male rats kept under three various diets resulting in a various degree of a growth inhibition and losses of weight of a body have been studied. There were selected diets giving to animals the food full-valued by composition but limited by quantity. Experiment proceeded 50 days. It was found out various metabolic strategy of adaptation in young and adult animals in reply to this influence. Experimentally this phenomenon revealed itself in various correlations between researched metabolic parameters at young and adult rats. Activity of researched enzymes in adult animals changed in a greater degree in comparison with a base level than at young ones. Researchers suppose that the revealed distinctions of metabolic strategy of adaptation in young and adult animals can be attributed to their generated epigenotypes.
Bozhkov
A I
AI
Dlubovskaia
V L
VL
Maleev
V A
VA
Dmitriev
Iu V
IuV
Beletskaia
L B
LB
D000222:Adaptation, Physiological; D000375:Aging / Q000502:physiology*; D000821:Animal Feed; D000818:Animals; D001835:Body Weight; D004032:Diet; D004734:Energy Metabolism; D006128:Growth / Q000502:physiology*; D008297:Male; D044342:Malnutrition / Q000378:metabolism* / Q000503:physiopathology; D051381:Rats; D017208:Rats, Wistar