title: [Pathogenicity of Corynebacterium diphtheriae circulating in Rostov-on-Don City and Rostov region during interepidemic period].
abstract: Main pathogenic characteristics (toxin production, tox-gene detection, adhesiveness) of 59 strains of C. diphtheriae circulating in Rostov-on-Don city and Rostov region in 2004-2005 were studied. Study of toxigenicity of 15 tox+ C.di phtheriae strains showed full coincidence of Elek immunoprecipitation test and polymerase chain reaction (PCR). Presence of part of A-fragment of tox-gene was detected in 5 (11.4%) of 44 C. diphtheriae strains that were negative in Elek test. Hemagglutinating activity of toxin producing strains was intermediate (40%) or high (60%). Among non-toxigenic strains those with intermediate adhesiveness were predominated (45,5%), the intermediate or high adhesiveness was detected in strains positive in PCR. Obtained characteristics of C. diphtheriae can be useful for surveillance for diphtheria infection during interepidemic period.
authors.forename: G G
authors.initials: GG
authors.lastname: Kharseeva
authors.forename: E P
authors.initials: EP
authors.lastname: Moskalenko
authors.forename: A L
authors.initials: AL
authors.lastname: Trukhachev
authors.forename: T V
authors.initials: TV
authors.lastname: Mitrofanova
mesh_terms: D001422:Bacterial Adhesion; D003353:Corynebacterium diphtheriae / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D004165:Diphtheria / Q000382:microbiology / Q000517:prevention & control*; D004167:Diphtheria Toxin / Q000032:analysis / Q000235:genetics / Q000378:metabolism; D005798:Genes, Bacterial / Q000235:genetics; D006386:Hemagglutination Tests; D006801:Humans; D047468:Immunoprecipitation; D016133:Polymerase Chain Reaction; D012426:Russia / Q000453:epidemiology; D037521:Virulence Factors / Q000032:analysis*
chemical_list: D004167:Diphtheria Toxin; D037521:Virulence Factors