A ribonucleoside with pyrimido[4,5-d]pyrimidine-2,4,5,7-(1H,3H,6H,8H)-tetraone as a nucleobase, which universally binds to natural nucleosides.
A ribonucleoside with pyrimido[4,5-d]pyrimidine-2,4,5,7-(1H,3H,6H,8H)-tetraone, which is expected to serve as a universal base, was synthesized and binding affinity of this artificial nucleoside to natural nucleosides was investigated by UV analysis. As the result, it was revealed that the artificial derivative universally forms a base pair with four kinds of natural deoxyribonucleosides.
Kuroda
Kenji
K
Graduate School of Information Science, Nagoya University, Chikusa, Nagoya 464-8601, Japan.
Kodama
Hidehiko
H
Kataoka
Masanori
M
Hayakawa
Yoshihiro
Y
D020029:Base Pairing; D003853:Deoxyribonucleosides / Q000737:chemistry*; D011741:Pyrimidine Nucleosides / Q000737:chemistry*; D012263:Ribonucleosides / Q000138:chemical synthesis / Q000737:chemistry*
D003853:Deoxyribonucleosides; D011741:Pyrimidine Nucleosides; D012263:Ribonucleosides; C522073:pyrimido(4,5-d)pyrimidine-2,4,5,7-(1H,3H,6H,8H)-tetraone ribonucleoside