Particulate air pollution and nonfatal cardiac events. Part I. Air pollution, personal activities, and onset of myocardial infarction in a case-crossover study.
We conducted a prospective case-crossover study to assess the association of particulate air pollution with onset of nonfatal myocardial infarction (MI). Patients who had survived MIs between February 1999 and July 2001 were identified based on the Coronary Event Registry in Augsburg, Southern Germany. The study included 851 MI subjects with known date and time of MI who had survived the first 24 hours and had completed the Registry's standard interview. Of these subjects, 691 provided case and control information for subject-specific MI triggers collected by a diary assessing the 4 days before symptom onset. The exposures of interest were the total number concentration (TNC) of particles as an indicator for ultrafine particles and the mass of particles with an aerodynamic diameter no larger than 2.5 microm (PM2.5). We conducted conditional logistic regression analyses using different control-selection strategies in a case-crossover approach, and Poisson regression analyses of the time-series data.
Peters
Annette
A
Institute of Epidemiology of the GSF-National Research Center of Environmental and Health, Neuherberg, Germany. peters@gsf.de
von Klot
Stephanie
S
Heier
Margit
M
Trentinaglia
Ines
I
Cyrys
Josef
J
Hörmann
Allmut
A
Hauptmann
Michael
M
Wichmann
H Erich
HE
Löwel
Hannelore
H
D000203:Activities of Daily Living; D000328:Adult; D000368:Aged; D000393:Air Pollutants / Q000009:adverse effects* / Q000032:analysis; D016022:Case-Control Studies; D018592:Cross-Over Studies; D004781:Environmental Exposure / Q000009:adverse effects* / Q000032:analysis; D005260:Female; D005858:Germany / Q000453:epidemiology; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000453:epidemiology / Q000209:etiology*; D010316:Particle Size; D016012:Poisson Distribution; D011446:Prospective Studies; D012042:Registries; D012307:Risk Factors; D013997:Time Factors
D000393:Air Pollutants