title: Chronicles in drug discovery.
abstract: Chronicles in Drug Discovery features special interest reports on advances in drug discovery and development. This month we focus on the progress of the ongoing search for safe and effective chemopreventive agents. Chemoprevention is a strategy to decrease the risk of developing cancer by using agents that prevent or abrogate carcinogenic processes. Bowman- Birk inhibitor concentrate, budesonide, NCX-4016 and statins are all undergoing investigation in the clinical setting as potential chemopreventive agents for head and neck, lung, colon and breast cancers, respectively.
authors.affiliation: Prous Science Medical Information Department, Barcelona, Spain. journals@prous.com
authors.forename: Maria Angels
authors.initials: MA
authors.lastname: Moral
authors.forename: Valeria K
authors.initials: VK
authors.lastname: Khurdayan
authors.forename: Jordi
authors.initials: J
authors.lastname: Bozzo
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D016588:Anticarcinogenic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001241:Aspirin / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D019819:Budesonide / Q000494:pharmacology / Q000627:therapeutic use*; D002471:Cell Transformation, Neoplastic / Q000187:drug effects; D018890:Chemoprevention; D002986:Clinical Trials as Topic; D004353:Drug Evaluation, Preclinical; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D009369:Neoplasms / Q000517:prevention & control; D011230:Precancerous Conditions / Q000188:drug therapy; D014358:Trypsin Inhibitor, Bowman-Birk Soybean / Q000494:pharmacology / Q000627:therapeutic use*; D014361:Trypsin Inhibitors / Q000627:therapeutic use
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D016588:Anticarcinogenic Agents; D005938:Glucocorticoids; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D014358:Trypsin Inhibitor, Bowman-Birk Soybean; D014361:Trypsin Inhibitors; D019819:Budesonide; C102148:nitroaspirin; D001241:Aspirin