title: Validation study of fractional exhaled nitric oxide measurements using a handheld monitoring device.
abstract: We tested reproducibility of exhaled nitric oxide (FE(NO)) and inter-operator handling when measured with a handheld device, NIOX MINO. We enrolled 20 volunteers using a priori goals of acceptable reproducibility to be mean within-subject standard deviation less than 3 parts per billion (ppb) for FE(NO) measurements less than 30 ppb, and mean coefficient of variation less than 10% for FE(NO) measurements more than 30 ppb. Seventeen subjects with measurements less than 30 ppb displayed a mean standard deviation of 1.15, and 3 subjects with FE(NO) more than 30 ppb had a mean coefficient of variation of 2.4%. We conclude that NIOX MINO demonstrates excellent reproducibility for all ranges of FE(NO).
authors.affiliation: The Department of Emergency Medicine, Loma Linda University School of Medicine, 11234 Anderson Street, Loma Linda, CA 92354, USA. mgill@ahs.llumc.edu
authors.forename: Michelle
authors.initials: M
authors.lastname: Gill
authors.forename: Gavin R
authors.initials: GR
authors.lastname: Graff
authors.forename: Alan J
authors.initials: AJ
authors.lastname: Adler
authors.forename: Raed A
authors.initials: RA
authors.lastname: Dweik
mesh_terms: D000293:Adolescent; D000328:Adult; D001944:Breath Tests / Q000295:instrumentation*; D002648:Child; D004867:Equipment Design; D045853:Exhalation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide; D011446:Prospective Studies; D015203:Reproducibility of Results
chemical_list: D009569:Nitric Oxide