A three-component tandem reductive aldol reaction catalyzed by N-heterocyclic carbene-copper complexes.
[Structure: see text] An efficient catalytic system for the three-component coupling of electrophilic alkenes, aldehydes, and silane was optimized with a new family of copper N-heterocyclic carbene complexes. These catalysts do not require activation and show high activity (TOF>15,000 h-1) as well as some anti diastereoselectivity.
Welle
Alexandre
A
Unité de Chimie Organique et Médicinale, Place Louis Pasteur 1, Université catholique de Louvain, 1348 Louvain la Neuve, Belgium.
Díez-González
Silvia
S
Tinant
Bernard
B
Nolan
Steven P
SP
Riant
Olivier
O
D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D006571:Heterocyclic Compounds / Q000737:chemistry*; D006838:Hydrocarbons / Q000737:chemistry; D008697:Methane / Q000031:analogs & derivatives* / Q000737:chemistry; D008958:Models, Molecular; D010084:Oxidation-Reduction
D006571:Heterocyclic Compounds; D006838:Hydrocarbons; C030011:carbene; D003300:Copper; D008697:Methane