title: Malignant transformation of conus medullaris ganglioglioma: case report.
abstract: Intramedullary gangliogliomas are indolent tumors of the spine with rare cases of malignant transformation. Conus medullaris gangliogliomas are extremely rare but are usually associated with good clinical outcome after gross total resection. We describe the first reported case of a ganglioglioma of the conus medullaris that progressed to glioblastoma multiforme 1 year after subtotal resection and radiotherapy. The paraplegic patient lacked neurological function below the level of the lesion and thus was treated with cordectomy caudal to the root entry zones of the T10 sensory roots.
authors.affiliation: Department of Neurosurgery, University of Utah School of Medicine, 175 N Medical Drive, Salt Lake City, UT 84132, USA.
authors.forename: Amin
authors.initials: A
authors.lastname: Amini
authors.forename: Steven S
authors.initials: SS
authors.lastname: Chin
authors.forename: Meic H
authors.initials: MH
authors.lastname: Schmidt
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use; D003131:Combined Modality Therapy; D003606:Dacarbazine / Q000031:analogs & derivatives / Q000627:therapeutic use; D018303:Ganglioglioma / Q000150:complications / Q000473:pathology* / Q000628:therapy; D005909:Glioblastoma / Q000150:complications / Q000473:pathology* / Q000628:therapy; D006801:Humans; D008161:Lumbosacral Region; D008279:Magnetic Resonance Imaging; D008297:Male; D019635:Neurosurgical Procedures; D010264:Paraplegia / Q000209:etiology; D011878:Radiotherapy; D013120:Spinal Cord Neoplasms / Q000150:complications / Q000473:pathology* / Q000628:therapy; D000077204:Temozolomide
chemical_list: D000970:Antineoplastic Agents; D003606:Dacarbazine; D000077204:Temozolomide