Lactobacillus acidophilus modulates intestinal pain and induces opioid and cannabinoid receptors.
Abdominal pain is common in the general population and, in patients with irritable bowel syndrome, is attributed to visceral hypersensitivity. We found that oral administration of specific Lactobacillus strains induced the expression of mu-opioid and cannabinoid receptors in intestinal epithelial cells, and mediated analgesic functions in the gut-similar to the effects of morphine. These results suggest that the microbiology of the intestinal tract influences our visceral perception, and suggest new approaches for the treatment of abdominal pain and irritable bowel syndrome.
Rousseaux
Christel
C
Institut National de la Santé et de la Recherche Médicale (INSERM) U795, Hôpital Swynghedauw, Rue A Verhaeghe, 59037 Lille Cedex, France.
Thuru
Xavier
X
Gelot
Agathe
A
Barnich
Nicolas
N
Neut
Christel
C
Dubuquoy
Laurent
L
Dubuquoy
Caroline
C
Merour
Emilie
E
Geboes
Karen
K
Chamaillard
Mathias
M
Ouwehand
Arthur
A
Leyer
Greg
G
Carcano
Didier
D
Colombel
Jean-Frédéric
JF
Ardid
Denis
D
Desreumaux
Pierre
P
D015746:Abdominal Pain / Q000503:physiopathology* / Q000517:prevention & control; D000284:Administration, Oral; D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000494:pharmacology; D000818:Animals; D063387:Cannabinoid Receptor Antagonists; D003106:Colon / Q000187:drug effects / Q000382:microbiology / Q000503:physiopathology; D004305:Dose-Response Relationship, Drug; D019073:HT29 Cells; D006801:Humans; D007211:Indoles / Q000008:administration & dosage / Q000494:pharmacology; D007422:Intestines / Q000187:drug effects / Q000382:microbiology / Q000503:physiopathology*; D007779:Lactobacillus acidophilus / Q000502:physiology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009020:Morphine / Q000008:administration & dosage / Q000494:pharmacology; D009270:Naloxone / Q000008:administration & dosage / Q000494:pharmacology; D009292:Narcotic Antagonists / Q000008:administration & dosage / Q000494:pharmacology; D019936:Probiotics / Q000008:administration & dosage / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D043885:Receptor, Cannabinoid, CB2 / Q000037:antagonists & inhibitors / Q000096:biosynthesis / Q000502:physiology; D043882:Receptors, Cannabinoid / Q000096:biosynthesis / Q000502:physiology*; D011957:Receptors, Opioid / Q000096:biosynthesis / Q000502:physiology*; D017450:Receptors, Opioid, mu / Q000037:antagonists & inhibitors / Q000096:biosynthesis / Q000502:physiology; D012007:Rectum / Q000187:drug effects / Q000382:microbiology / Q000503:physiopathology
D000701:Analgesics, Opioid; D063387:Cannabinoid Receptor Antagonists; D007211:Indoles; D009292:Narcotic Antagonists; D043885:Receptor, Cannabinoid, CB2; D043882:Receptors, Cannabinoid; D011957:Receptors, Opioid; D017450:Receptors, Opioid, mu; D009270:Naloxone; D009020:Morphine; C094023:iodopravadoline