Constitutional complex chromosomal rearrangements in azoospermic men--case report and literature review.
Complex chromosomal rearrangements are very rare and may lead to spermatogenic defect. We report on an infertile man with complex constitutional chromosomal rearrangements. The chromosomal breakpoints were located at 9p22, 13q22, and 21p11. This is the seventh case, to our knowledge, of complex chromosome rearrangements in a man presenting with a spermatogenic defect. The spermatogenic defect may be ascribed to disruption of sterile genes during chromosomal breakage or abnormal meiotic segregation of the rearranged chromosomes.
Lee
I-Wen
IW
Department of Obstetrics and Gynecology, Tainan Hospital, Department of Health, Tainan, Taiwan.
Su
Mei-Tsz
MT
Hsu
Chao-Chin
CC
Lin
Ying-Hui
YH
Chen
Pei-Yi
PY
Kuo
Pao-Lin
PL
D000328:Adult; D053713:Azoospermia / Q000175:diagnosis / Q000235:genetics*; D019457:Chromosome Breakage; D002882:Chromosomes, Human, Pair 13; D002891:Chromosomes, Human, Pair 21; D002899:Chromosomes, Human, Pair 9; D006801:Humans; D008297:Male; D012307:Risk Factors; D014178:Translocation, Genetic / Q000235:genetics*