title: euHCVdb: the European hepatitis C virus database.
abstract: The hepatitis C virus (HCV) genome shows remarkable sequence variability, leading to the classification of at least six major genotypes, numerous subtypes and a myriad of quasispecies within a given host. A database allowing researchers to investigate the genetic and structural variability of all available HCV sequences is an essential tool for studies on the molecular virology and pathogenesis of hepatitis C as well as drug design and vaccine development. We describe here the European Hepatitis C Virus Database (euHCVdb, http://euhcvdb.ibcp.fr), a collection of computer-annotated sequences based on reference genomes. The annotations include genome mapping of sequences, use of recommended nomenclature, subtyping as well as three-dimensional (3D) molecular models of proteins. A WWW interface has been developed to facilitate database searches and the export of data for sequence and structure analyses. As part of an international collaborative effort with the US and Japanese databases, the European HCV Database (euHCVdb) is mainly dedicated to HCV protein sequences, 3D structures and functional analyses.
authors.affiliation: Institut de Biologie et Chimie des Protéines (UMR5086), CNRS, University of Lyon 1, IFR 128 BioSciences, Lyon-Gerland, France. c.combet@ibcp.fr
authors.forename: Christophe
authors.initials: C
authors.lastname: Combet
authors.forename: Nicolas
authors.initials: N
authors.lastname: Garnier
authors.forename: Céline
authors.initials: C
authors.lastname: Charavay
authors.forename: Delphine
authors.initials: D
authors.lastname: Grando
authors.forename: Daniel
authors.initials: D
authors.lastname: Crisan
authors.forename: Julien
authors.initials: J
authors.lastname: Lopez
authors.forename: Alexandre
authors.initials: A
authors.lastname: Dehne-Garcia
authors.forename: Christophe
authors.initials: C
authors.lastname: Geourjon
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Bettler
authors.forename: Chantal
authors.initials: C
authors.lastname: Hulo
authors.forename: Philippe
authors.initials: P
authors.lastname: Le Mercier
authors.forename: Ralf
authors.initials: R
authors.lastname: Bartenschlager
authors.forename: Helmut
authors.initials: H
authors.lastname: Diepolder
authors.forename: Darius
authors.initials: D
authors.lastname: Moradpour
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Pawlotsky
authors.forename: Charles M
authors.initials: CM
authors.lastname: Rice
authors.forename: Christian
authors.initials: C
authors.lastname: Trépo
authors.forename: François
authors.initials: F
authors.lastname: Penin
authors.forename: Gilbert
authors.initials: G
authors.lastname: Deléage
mesh_terms: D030562:Databases, Protein; D016679:Genome, Viral; D023281:Genomics; D016174:Hepacivirus / Q000235:genetics*; D020407:Internet; D008958:Models, Molecular; D011487:Protein Conformation; D020539:Sequence Analysis, Protein; D014584:User-Computer Interface; D014764:Viral Proteins / Q000737:chemistry* / Q000235:genetics*
chemical_list: D014764:Viral Proteins