title: Basis of decreased risk of gastric cancer in severe atrophic gastritis with eradication of Helicobacter pylori.
abstract: Helicobacter pylori infection induces chronic gastritis and lowers gastric juice ascorbic acid concentrations. We investigated how H. pylori eradication affected multiple variables that could prevent or delay development of new or occult gastric cancer in patients with early gastric cancer treated by endoscopic mucosal resection. Gastric juice pH, nitrite concentrations, and total vitamin C concentrations, serum concentrations of vitamin C and specific H. pylori antibody, and intensity of neutrophil infiltration in gastric mucosa were determined before and after successful H. pylori eradication. Successful eradication increased acid output and ascorbic acid secretion into gastric juice, accompanied by disappearance of polymorphonuclear infiltration from the surface epithelium and decreased gastric juice nitrite concentrations. Our data suggest that H. pylori eradication decreases the nitrosation rate as the ratio of vitamin C to nitrite increases. This decreases reactive oxygen species and nitric oxide, eliminating their damaging effect on DNA and reducing cell turnover.
authors.affiliation: Department of Internal Medicine, Hiroshima Red Cross Hospital & Atomic-Bomb Survivors Hospital, 1-9-6 Senda-machi, Hiroshima, 730-8619, Japan. atari7mb@pc4.so-net.ne.jp
authors.forename: Akira
authors.initials: A
authors.lastname: Tari
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Kitadai
authors.forename: Masaharu
authors.initials: M
authors.lastname: Sumii
authors.forename: Atsunori
authors.initials: A
authors.lastname: Sasaki
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Tani
authors.forename: Sinji
authors.initials: S
authors.lastname: Tanaka
authors.forename: Kazuaki
authors.initials: K
authors.lastname: Chayama
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001205:Ascorbic Acid / Q000032:analysis / Q000097:blood; D005260:Female; D005750:Gastric Juice / Q000737:chemistry; D005753:Gastric Mucosa / Q000382:microbiology; D005755:Gastrins / Q000097:blood; D005757:Gastritis, Atrophic / Q000150:complications* / Q000382:microbiology*; D016481:Helicobacter Infections / Q000150:complications* / Q000188:drug therapy; D016480:Helicobacter pylori; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008875:Middle Aged; D009573:Nitrites / Q000032:analysis; D013274:Stomach Neoplasms / Q000209:etiology* / Q000378:metabolism
chemical_list: D005755:Gastrins; D009573:Nitrites; D001205:Ascorbic Acid