[Dyslipidemia and schizophrenia].
OBJECTIVE
There is some evidence that the treatment with new ("atypical") neuroleptics is associated with a higher frequency of hyperlipidemia.


OBJECTIVE
In this study the serum lipid levels of patients with chronic schizophrenia were investigated.


METHODS
The serum lipid levels of 177 consecutively admitted schizophrenic patients treated at least 5 years were evaluated.


RESULTS
No gender differences of lipid concentrations could be detected. A considerable rate of the patients (35.6 %) showed elevated triglycerides (> 150 mg/dl) or elevated cholesterol levels (> 200 mg/dl; 43.9 %). The rate of patients with elevated cholesterol or triglyceride concentrations is associated with the duration of treatment. The comparison of different groups of neuroleptics yielded at best a trend to higher triglyceride levels in the patients treated with dibenzodiazepines compared to those receiving only classical neuroleptics. The triglyceride concentrations correlated with the body mass index (rho = 0.25, p < 0.01).


CONCLUSIONS
This study revealed evidence for an association of the rate of patients with elevated lipid levels and duration of neuroleptic treatment in schizophrenia patients.
Wetterling
Tilman
T
Klinik für Psychiatrie und Psychotherapie, J.-W.-Goethe-Universität, Frankfurt/M. tilman.wetterling@vivantes.de
Schneider
Barbara
B
Weber
Bernhard
B
D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D002784:Cholesterol / Q000097:blood; D002908:Chronic Disease; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood / Q000139:chemically induced*; D015228:Hypertriglyceridemia / Q000097:blood / Q000139:chemically induced*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D012559:Schizophrenia / Q000097:blood / Q000188:drug therapy*; D014280:Triglycerides / Q000097:blood
D014150:Antipsychotic Agents; D014280:Triglycerides; D002784:Cholesterol