[Effect of dopamine combined with norepinephrine on the renal function in patients with septic shock].
OBJECTIVE
To investigate the effects of dopamine and norepinephrine on the renal function in the patients with septic shock.


METHODS
Eighty-seven patients with septic shock were divided into three groups (group A, B, C) according to the biggest infusing rate of norepinephrine, with the infusing rate of 0.5 - 0.9, 1.0 - 1.5, 1.6 - 2.0 microg x kg(-1) x min(-1), respectively. Mean arterial blood pressure (MAP), heart rate (HR), urine output, blood urea nitrogen (BUN), creatinine (CRE), urine albumin (U-ALB) and urine beta(2)-microglobulin (Ubeta(2)-MG) as well as APACHE III score in all the patients were detected.


RESULTS
Before anti-shock therapy was given, hypotension, tachycardia and oliguria occurred in all the 87 patients, and CRE, BUN, U-ALB, Ubeta(2)-MG and APACHE III score were abnormal in most cases. With the anti-shock therapy, MAP, HR, urine output and BUN, CRE in all patients returned to normal levels gradually, and U-ALB, Ubeta(2)-MG levels and APACHE III score also restored but still remained abnormal.


CONCLUSIONS
The first aim of treating septic shock should be restoring the organ blood supply, and based on volume resuscitation, dopamine, noradrenaline and other vasoactive drugs could be combined to maintain circulatory stability.
Hou
Li-chao
LC
Department of Anesthesiology, Xijing Hospital, the Fourth Military Medical University, Xi'an 710032, China.
Ji
Gen-lin
GL
Xiong
Li-ze
LZ
Chen
Shao-yang
SY
Chen
Min
M
Huo
Ting-ting
TT
Hu
Wen-neng
WN
Wang
Ya-li
YL
Wang
Chen
C
Bai
Xiao-guang
XG
D018806:APACHE; D000328:Adult; D000368:Aged; D001803:Blood Transfusion; D002316:Cardiotonic Agents / Q000008:administration & dosage*; D003131:Combined Modality Therapy; D004298:Dopamine / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007668:Kidney / Q000187:drug effects / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009638:Norepinephrine / Q000008:administration & dosage*; D012189:Retrospective Studies; D012772:Shock, Septic / Q000503:physiopathology / Q000628:therapy*; D014662:Vasoconstrictor Agents / Q000008:administration & dosage*
D002316:Cardiotonic Agents; D014662:Vasoconstrictor Agents; D004298:Dopamine; D009638:Norepinephrine