title: Pharmacokinetics-pharmacodynamics of antimicrobial therapy: it's not just for mice anymore.
abstract: Since the advent of the modern era of antimicrobial chemotherapy in the 1930s, animal infection models have allowed for the in vivo evaluation of antimicrobial agents for the treatment of experimentally induced infection. Today, animal pharmacokinetic-pharmacodynamic (PK-PD) infection models serve as a cornerstone of the preclinical assessment process for antibacterial agents and dose and dosing interval selection, as decision support for setting in vitro susceptibility breakpoints, and, finally, for the evaluation of the meaning of in vitro resistance. Over the past 15 years, considerable PK-PD data have been derived from infected patients for many classes of antimicrobial agents. These data provide the opportunity to confirm knowledge gained from animal PK-PD infection models.
authors.affiliation: Institute for Clinical Pharmacodynamics, Ordway Research Institute, Albany, NY 12208, USA. PAmbrose-ICPD@OrdwayResearch.org
authors.forename: Paul G
authors.initials: PG
authors.lastname: Ambrose
authors.forename: Sujata M
authors.initials: SM
authors.lastname: Bhavnani
authors.forename: Christopher M
authors.initials: CM
authors.lastname: Rubino
authors.forename: Arnold
authors.initials: A
authors.lastname: Louie
authors.forename: Tawanda
authors.initials: T
authors.lastname: Gumbo
authors.forename: Alan
authors.initials: A
authors.lastname: Forrest
authors.forename: George L
authors.initials: GL
authors.lastname: Drusano
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D019540:Area Under Curve; D016470:Bacteremia / Q000188:drug therapy / Q000382:microbiology; D001424:Bacterial Infections / Q000188:drug therapy* / Q000382:microbiology; D017714:Community-Acquired Infections / Q000188:drug therapy* / Q000382:microbiology; D004195:Disease Models, Animal; D006801:Humans; D051379:Mice; D012141:Respiratory Tract Infections / Q000188:drug therapy / Q000382:microbiology; D017192:Skin Diseases, Bacterial / Q000188:drug therapy / Q000382:microbiology
chemical_list: D000900:Anti-Bacterial Agents