The central role of osteoblasts in the metastasis of prostate cancer.
Prostate cancer (PCa) is the most common malignancy in men. Although mortality from PCa has been declining over the past decade, metastasis can substantially shorten survival time and remains a major challenge in maintaining quality of life for survivors. PCa cells preferentially metastasize to bone and typically result in osteoblastic lesions. In the late stages of disease, however, osteolytic lesions are observed. The mechanisms of PCa bone metastasis are still unclear, but relationships between the PCa cells and the bone tissue elements are suspected of being more complex than initially thought. Far from being an innocent bystander, the bone participates actively in the metastatic process and provides the cancer cells with growth factors and a fertile environment. Among the various cells in the bone environment, osteoblasts have a central role through their bidirectional interactions with the PCa cells. This review discusses the possible mechanisms of PCa bone metastasis and highlights the essential role of osteoblasts in the metastasis of PCa to bone.
Choueiri
Michel B
MB
Department of Molecular Pathology, The University of Texas M D Anderson Cancer Center, Houston, TX, USA. mchoueir@mdanderson.org
Tu
Shi-Ming
SM
Yu-Lee
Li-Yuan
LY
Lin
Sue-Hwa
SH
D000818:Animals; D001859:Bone Neoplasms / Q000378:metabolism* / Q000473:pathology* / Q000628:therapy; D066246:ErbB Receptors / Q000378:metabolism; D006801:Humans; D008297:Male; D010006:Osteoblasts / Q000378:metabolism / Q000473:pathology*; D011471:Prostatic Neoplasms / Q000378:metabolism / Q000473:pathology*; D020893:Receptor, ErbB-3
C507128:MDA-BF-1, human; D066246:ErbB Receptors; D020893:Receptor, ErbB-3