title: Remineralisation of carious enamel lesions after application of a CHX/F-mouthrinse compared with sole CHX- and placebo-application.
abstract: OBJECTIVE
  The purpose of this cross-over, double-blind, placebo-controlled, randomised in situ study was to evaluate the remineralisation of demineralised enamel specimens using a CHX/NaF mouthrinse in comparison with a CHX- and a placebo-mouthrinse.
  
  
  METHODS
  Twenty-four volunteers received intraoral appliances with mounted demineralised enamel specimens. They rinsed their mouths twice a day (10 ml for 1 minute) with the respective preparation. After 14 days, the in situ mineral gain and fluoride uptake were determined.
  
  
  RESULTS
  Mineral gain was significantly higher after using CHX/F mouthrinse (358.4 +/- 372.1 Vol.% X microm) compared with CHX (95.6+/-192.2 Vol.% X microm) and placebo treatment (80.8 +/- 159.6 Vol.% x microm). Moreover, CHX/F treatment (2751.1+/-1494.9 microg/cm(3)) resulted in a significantly higher fluoride uptake compared with CHX- (83.8+/-94.0 microg/cm(3)) and placebo- (136.6+/-137.3 microg/cm(3)) mouthrinses.
  
  
  CONCLUSIONS
  The in situ study approves that using a CHX/F mouthrinse supports the remineralisation of initial carious lesions.
authors.affiliation: Department of Operative Dentistry and Periodontology, Albert-Ludwigs-University of Freiburg, Germany. markus.altenburger@uniklinik-freiburg.de
authors.forename: Markus Jörg
authors.initials: MJ
authors.lastname: Altenburger
authors.forename: Manfred
authors.initials: M
authors.lastname: Klasser
authors.forename: Jörg Fabian
authors.initials: JF
authors.lastname: Schirrmeister
authors.forename: Elmar
authors.initials: E
authors.lastname: Hellwig
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D000818:Animals; D002327:Cariostatic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D002417:Cattle; D002710:Chlorhexidine / Q000009:adverse effects / Q000627:therapeutic use*; D018592:Cross-Over Studies; D004311:Double-Blind Method; D004338:Drug Combinations; D004408:Dysgeusia / Q000139:chemically induced; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa / Q000187:drug effects; D009067:Mouthwashes / Q000009:adverse effects / Q000627:therapeutic use*; D012969:Sodium Fluoride / Q000009:adverse effects / Q000627:therapeutic use*; D017001:Tooth Demineralization / Q000188:drug therapy*; D014089:Tooth Remineralization / Q000379:methods*
chemical_list: D002327:Cariostatic Agents; D004338:Drug Combinations; D009067:Mouthwashes; D012969:Sodium Fluoride; D002710:Chlorhexidine