The effects of dopamine on the respiratory system: friend or foe?
Dopamine (DA) is an immediate precursor of noradrenaline that has stimulatory or inhibitory effects on a variety of adrenergic receptors. DA is primarily used in the management of circulatory shock for its combined vasopressor and inotropic effects, but it may also exert significant effects on the respiratory system Although the respiratory effects of intravenous DA attract less attention than its hemodynamic effects, there is evidence that DA affects ventilation, pulmonary circulation, bronchial diameter, neuromodulation of sensory pulmonary nerves and lung water clearance. Through these complex mechanisms, DA may exert beneficial as well as detrimental effects on respiration. DA may have beneficial effects on the respiratory system by decreasing oedema formation and improving respiratory muscle function, but can also have deleterious effects, by inhibiting ventilation. Hence, DA may be beneficial in lung oedema, but harmful in cases of difficult weaning from mechanical ventilation. DA should be used with caution in patients with heart failure during weaning from mechanical respiration; however, critically ill patients with chronic obstructive pulmonary disease (COPD) do not show this negative effect of DA on ventilatory drive.
Ciarka
Agnieszka
A
Cardiology Department, Erasme University Hospital, Free University of Brussels, Belgium. aciarka@ulb.ac.be
Vincent
Jean-Louis
JL
van de Borne
Philippe
P
D000818:Animals; D004298:Dopamine / Q000494:pharmacology* / Q000627:therapeutic use; D015633:Extravascular Lung Water / Q000187:drug effects; D006801:Humans; D029424:Pulmonary Disease, Chronic Obstructive / Q000188:drug therapy; D012119:Respiration / Q000187:drug effects*; D012129:Respiratory Function Tests; D012132:Respiratory Muscles / Q000187:drug effects; D013566:Sympathomimetics / Q000494:pharmacology* / Q000627:therapeutic use
D013566:Sympathomimetics; D004298:Dopamine