title: Synthesis of L-beta-3'-deoxy-3',3'-difluoro-4'-thionucleosides.
abstract: [Structure: see text] An efficient route to L-beta-3'-deoxy-3',3'-difluoro-4'-thionucleosides, thio-containing analogues of highly bioactive gemcitabine, is described. Our synthesis highlighted the installation of the thioacetyl group in high efficiency and construction of 3-deoxy-3,3-difluorothiofuranose skeleton in a novel method.
authors.affiliation: Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Zheng
authors.forename: Xiao-Hua
authors.initials: XH
authors.lastname: Zhang
authors.forename: Xiao-Long
authors.initials: XL
authors.lastname: Qiu
authors.forename: Xingang
authors.initials: X
authors.lastname: Zhang
authors.forename: Feng-Ling
authors.initials: FL
authors.lastname: Qing
mesh_terms: D008958:Models, Molecular; D019906:Nuclear Magnetic Resonance, Biomolecular; D013872:Thionucleosides / Q000138:chemical synthesis*
chemical_list: D013872:Thionucleosides