title: Tumor macrophage redox and effector mechanisms associated with hypoxia.
abstract: Monocytes are recruited from the circulation into solid tumors where they differentiate into macrophages with unique phenotypes. While macrophages utilize oxygen in a broad range of immune effector functions, the generation of reactive oxygen and nitrogen oxide species is less clear in the setting of hypoxia, which can be a prominent feature of solid tumors. The relationships among innate immunity, redox systems, and the plasticity of phenotypic changes tumor-associated macrophages undergo in conjunction with tumor hypoxia will be examined.
authors.affiliation: Radiation Biology Branch, National Cancer Institute, NIH, 10/B3-B69, 9000 Rockville Pike, Bethesda, MD 20892, USA. SP@nih.gov
authors.forename: Michael Graham
authors.initials: MG
authors.lastname: Espey
mesh_terms: D000818:Animals; D006801:Humans; D000860:Hypoxia / Q000209:etiology* / Q000473:pathology; D007113:Immunity, Innate; D008264:Macrophages / Q000378:metabolism* / Q000473:pathology; D009369:Neoplasms / Q000150:complications* / Q000473:pathology / Q000628:therapy; D010084:Oxidation-Reduction