title: Is mega dose of methotrexate beneficial to patients with acute lymphoblastic leukemia?
authors.affiliation: Departments of Oncology and Pharmaceutical Sciences, St Jude Children's Research Hospital, and Colleges of Medicine and Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee 38105, USA. ching-hon.pui@stjude.org
authors.forename: Ching-Hon
authors.initials: CH
authors.lastname: Pui
authors.forename: Mary V
authors.initials: MV
authors.lastname: Relling
authors.forename: William E
authors.initials: WE
authors.lastname: Evans
mesh_terms: D002490:Central Nervous System / Q000187:drug effects; D016543:Central Nervous System Neoplasms / Q000188:drug therapy; D002648:Child; D002986:Clinical Trials as Topic; D006801:Humans; D002955:Leucovorin / Q000627:therapeutic use; D008727:Methotrexate / Q000627:therapeutic use*; D010865:Pilot Projects; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy*; D016032:Randomized Controlled Trials as Topic; D012008:Recurrence; D012306:Risk
chemical_list: D002955:Leucovorin; D008727:Methotrexate