Targeting translation in hypoxic tumors.
Recent insight into how mammalian cells adapt their translational machinery to hypoxic conditions raises the possibility of targeting components of the regulatory networks involved to selectively inhibit metabolically compromised tumor cells and possibly manipulate a broad range of other physiological processes.
Ron
David
D
Skirball Institute of Biomolecular Medicine and the Department of Medicine, New York University School of Medicine, New York, New York 10016, USA. ron@saturn.med.nyu.edu
Hinnebusch
Alan G
AG
D000818:Animals; D015687:Cell Hypoxia / Q000235:genetics*; D039561:Eukaryotic Initiation Factor-4E / Q000378:metabolism; D015972:Gene Expression Regulation, Neoplastic; D006706:Homeostasis; D006801:Humans; D008322:Mammals; D008954:Models, Biological; D009363:Neoplasm Proteins / Q000235:genetics; D009369:Neoplasms / Q000098:blood supply / Q000235:genetics* / Q000473:pathology*; D010101:Oxygen Consumption; D014176:Protein Biosynthesis
D039561:Eukaryotic Initiation Factor-4E; D009363:Neoplasm Proteins