IL-6 signaling pathway in keloids: a target for pharmacologic intervention?
Keloids are cosmetically devastating lesions with considerable morbidity. Ghazizadeh et al. document enhanced expression of IL-6 and its receptors in keloid fibroblasts, with a concomitant increase in collagen biosynthesis. Anti-IL-6 antibodies or blocking the IL-6 receptors elicits reduced collagen synthesis, suggesting a role for IL-6 in the regulation of collagen gene expression. These observations imply the feasibility of a pharmacologic platform, based on the targeting of the IL-6 signaling pathway, in keloids.
Uitto
Jouni
J
Department of Dermatology and Cutaneous Biology, Jefferson Medical College, and Jefferson Institute of Molecular Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA. Jouni.Uitto@jefferson.edu
D003094:Collagen / Q000378:metabolism; D006801:Humans; D015850:Interleukin-6 / Q000502:physiology; D007627:Keloid / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects*; D000093242:Interleukin-6 Inhibitors
D003094:Collagen; D015850:Interleukin-6; D000093242:Interleukin-6 Inhibitors