title: In vitro inhibition of acetylcholinesterase by crude plant extracts from Colombian flora.
abstract: The methanol extracts from five different plant families (Asteraceae, Euphorbiaceae, Melastomataceae, Rubiaceae, and Solanaceae) collected at Regional Natural Park Ucumarí (Colombia), were screened for their acetylcholinesterase inhibitory activity through the modified Ellman's spectrophotometric method. The best inhibitory activities on this study were shown by the extracts of Solanum leucocarpum Dunal (IC50 = 204.59 mg/l) and Witheringia coccoloboides (Damm) (IC50 = 220.68 mg/l), both plants belonging to the Solanaceae family.
authors.affiliation: Grupo de Biotecnología-Productos Naturales, Escuela de Tecnología Química, Universidad Tecnológica de Pereira, Pereira, Risaralda, Colombia. janino@utp.edu.co
authors.forename: Jaime
authors.initials: J
authors.lastname: Niño
authors.forename: Jimmy A
authors.initials: JA
authors.lastname: Hernández
authors.forename: Yaned M
authors.initials: YM
authors.lastname: Correa
authors.forename: Oscar M
authors.initials: OM
authors.lastname: Mosquera
mesh_terms: D000110:Acetylcholinesterase; D019659:Asteraceae / Q000737:chemistry; D002800:Cholinesterase Inhibitors / Q000302:isolation & purification / Q000494:pharmacology*; D003105:Colombia; D019665:Euphorbiaceae / Q000737:chemistry; D020128:Inhibitory Concentration 50; D019684:Magnoliopsida / Q000737:chemistry*; D035322:Melastomataceae / Q000737:chemistry; D010936:Plant Extracts / Q000494:pharmacology; D019666:Rubiaceae / Q000737:chemistry; D019657:Solanaceae / Q000737:chemistry; D013053:Spectrophotometry
chemical_list: D002800:Cholinesterase Inhibitors; D010936:Plant Extracts; D000110:Acetylcholinesterase