title: Iron overload in the liver diagnostic and quantification.
abstract: Hereditary Hemochromatosis is the most frequent modality of iron overload. Since 1996 genetic tests have facilitated significantly the non-invasive diagnosis of the disease. There are however many cases of negative genetic tests that require confirmation by hepatic iron quantification which is traditionally performed by hepatic biopsy. There are many studies that have demonstrated the possibility of performing hepatic iron quantification with Magnetic Resonance. However, a consensus has not been reached yet regarding the technique or the possibility to reproduce the same method of calculus in different machines. This article reviews the state of the art of the question and delineates possible future lines to standardise this non-invasive method of hepatic iron quantification.
authors.affiliation: Osatek SA, P Dr. Beguiristain 109, 20014, San Sebastian, Guipuzcoa, Spain. jmalustiza@osatek.es
authors.forename: Jose M
authors.initials: JM
authors.lastname: Alústiza
authors.forename: Agustin
authors.initials: A
authors.lastname: Castiella
authors.forename: Maria D
authors.initials: MD
authors.lastname: De Juan
authors.forename: Jose I
authors.initials: JI
authors.lastname: Emparanza
authors.forename: Jose
authors.initials: J
authors.lastname: Artetxe
authors.forename: Maite
authors.initials: M
authors.lastname: Uranga
mesh_terms: D006432:Hemochromatosis / Q000175:diagnosis* / Q000235:genetics / Q000378:metabolism; D006801:Humans; D007501:Iron / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008279:Magnetic Resonance Imaging
chemical_list: D007501:Iron