title: [Polymorphic analysis of two Y chromosome short tandem repeat loci in Chinese Chengdu Han population].
abstract: OBJECTIVE
  To reveal the distribution of genetic polymorphism of two novel Y chromosome short tandem repeat (Y-STR) loci (DYS508, DYS516) in Chinese Chengdu Han population.
  
  
  METHODS
  Two Y-STR loci were amplified with PCR. The products of PCR were analyzed with polyacrylamide gel electrophoresis. Each allele of these 2 Y-STR loci was sequenced and the allele ladders were constructed. Alleles of these Y-STR loci were nominated according to recommendations of the International Society of Forensic Genetics (ISFG).
  
  
  RESULTS
  Six and 6 alleles were observed in loci DYS508 and DYS516 respectively. The gene diversity of DYS508 and DYS516 was 0.7242 and 0.7931 respectively. The diversity of haplotype for these Y-STR loci was 0.9397. The value of discrimination power and the exclusion chance of paternity for these Y-STR loci were same as the value of haplotype diversity.
  
  
  CONCLUSIONS
  Both Y-STR loci are high genetic polymorphic. They are beneficial to the test of male-female mixtures and paternity identification in forensic science.
authors.affiliation: Department of Pathology, College of Basic Medical Sciences, Fujian Medical University, Fuzhou, Fujian, 350004, P. R. China.
authors.forename: Jing-dong
authors.initials: JD
authors.lastname: Lin
authors.forename: Ai-ming
authors.initials: AM
authors.lastname: Huang
authors.forename: Jian-wen
authors.initials: JW
authors.lastname: Huang
mesh_terms: D044466:Asian People / Q000235:genetics*; D002681:China; D041322:Chromosomes, Human, Y / Q000235:genetics*; D005260:Female; D053803:Forensic Genetics / Q000379:methods; D005787:Gene Frequency; D006239:Haplotypes; D006801:Humans; D008297:Male; D010334:Paternity; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D020080:Tandem Repeat Sequences