title: Rapid clearance of Lyme disease spirochetes lacking OspC from skin.
abstract: We previously demonstrated that Borrelia burgdorferi requires OspC to colonize a mammalian host. To delineate this requirement, we analyzed the clearance of ospC mutant spirochetes and found that they were eliminated within 48 h. We conclude that B. burgdorferi uses OspC to resist innate host defenses immediately after transmission.
authors.affiliation: Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA. ktilly@niaid.nih.gov
authors.forename: Kit
authors.initials: K
authors.lastname: Tilly
authors.forename: Aaron
authors.initials: A
authors.lastname: Bestor
authors.forename: Mollie W
authors.initials: MW
authors.lastname: Jewett
authors.forename: Patricia
authors.initials: P
authors.lastname: Rosa
mesh_terms: D000818:Animals; D000942:Antigens, Bacterial / Q000235:genetics; D001425:Bacterial Outer Membrane Proteins / Q000235:genetics; D025065:Borrelia burgdorferi / Q000235:genetics / Q000254:growth & development* / Q000276:immunology*; D017353:Gene Deletion; D007113:Immunity, Innate / Q000235:genetics; D008193:Lyme Disease / Q000276:immunology / Q000382:microbiology* / Q000635:transmission; D051379:Mice; D008809:Mice, Inbred C3H; D017192:Skin Diseases, Bacterial / Q000276:immunology / Q000382:microbiology / Q000635:transmission
chemical_list: D000942:Antigens, Bacterial; D001425:Bacterial Outer Membrane Proteins; C079616:OspC protein