RNA recognition and recognition control of alpha-peptide ribonucleic acids containing arginine residue by external factors.
A novel nucleic acid model using alpha-peptide ribonucleic acid (alpha-PRNA) possessing alternative alpha-PRNA/lysine and alpha-PRNA/arginine sequences, where the lysine or arginine residue are expected to stabilize the complex not only by the conventional hydrogen-bonding interactions between the complementary nucleobase pairs but also through the electrostatic interactions between basic amino acid side-chain groups and DNA's phosphate anions on the backbone. These alpha-PRNAs form stable sequence-specific complex with the complementary DNA.
Wada
Takehiko
T
Department of Applid Chemistry, Graduate School of Engineering, Osaka University, Yamada-oka, Suita 565-0871, Japan.
Maeda
Yoshiki
Y
Sawa
Nobuya
N
Sato
Hirofumi
H
Futaki
Shiroh
S
Inoue
Yoshihisa
Y
D001120:Arginine / Q000737:chemistry*; D001881:Borates / Q000737:chemistry; D002942:Circular Dichroism; D004247:DNA / Q000737:chemistry; D008239:Lysine / Q000737:chemistry; D009691:Nucleic Acid Denaturation; D009693:Nucleic Acid Hybridization; D009841:Oligonucleotides / Q000138:chemical synthesis / Q000737:chemistry; D010455:Peptides / Q000737:chemistry*; D012313:RNA / Q000737:chemistry*
D001881:Borates; D009841:Oligonucleotides; D010455:Peptides; D012313:RNA; D004247:DNA; D001120:Arginine; D008239:Lysine