title: Statistical analysis for haplotype-based matched case-control studies.
abstract: Using unphased genotype data, we studied statistical inference for association between a disease and a haplotype in matched case-control studies. Statistical inference for haplotype data is complicated due to ambiguity of genotype phases. An estimating equation-based method is developed for estimating odds ratios and testing disease-haplotype association. The method potentially can also be applied to testing haplotype-environment interaction. Simulation studies show that the proposed method has good performance. The performance of the method in the presence of departures from Hardy-Weinberg equilibrium is also studied.
authors.affiliation: Department of Statistics and Finance, University of Science and Technology of China, 96 Jinzhai Road, Hefei, Anhui 230026, China.
authors.forename: H
authors.initials: H
authors.lastname: Zhang
authors.forename: G
authors.initials: G
authors.lastname: Zheng
authors.forename: Z
authors.initials: Z
authors.lastname: Li
mesh_terms: D001699:Biometry / Q000379:methods*; D016022:Case-Control Studies; D002892:Chromosomes, Human, Pair 22 / Q000235:genetics; D005787:Gene Frequency; D023281:Genomics / Q000706:statistics & numerical data; D006239:Haplotypes; D006801:Humans; D016015:Logistic Models; D008957:Models, Genetic; D020641:Polymorphism, Single Nucleotide; D012507:Sarcoidosis / Q000235:genetics