title: Sef and Sprouty expression in the developing ocular lens: implications for regulating lens cell proliferation and differentiation.
abstract: In many developmental systems, growth factor signalling must be temporally and spatially regulated, and this is commonly achieved by growth factor antagonists. Here, we describe the expression patterns of newly identified growth factor inhibitors, Sprouty and Sef, in the developing ocular lens. Sprouty and Sef are both expressed in the lens throughout embryogenesis, and become restricted to the lens epithelium, indicating that lens cell proliferation and fibre differentiation may be tightly regulated by such antagonists. Future studies will be aimed at understanding how these negative regulatory molecules modulate growth factor-induced signalling pathways and cellular processes in the lens.
authors.affiliation: Save Sight Institute, University of Sydney, NSW, Australia.
authors.forename: Jessica
authors.initials: J
authors.lastname: Boros
authors.forename: Peter
authors.initials: P
authors.lastname: Newitt
authors.forename: Qian
authors.initials: Q
authors.lastname: Wang
authors.forename: John W
authors.initials: JW
authors.lastname: McAvoy
authors.forename: Frank J
authors.initials: FJ
authors.lastname: Lovicu
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000502:physiology*; D049109:Cell Proliferation; D004848:Epithelium / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D007908:Lens, Crystalline / Q000166:cytology / Q000196:embryology* / Q000502:physiology; D008565:Membrane Proteins / Q000096:biosynthesis* / Q000235:genetics; D051379:Mice; D009419:Nerve Tissue Proteins / Q000096:biosynthesis* / Q000235:genetics; D051381:Rats; D017208:Rats, Wistar; D018123:Receptors, Interleukin / Q000096:biosynthesis / Q000235:genetics; D053722:Receptors, Interleukin-17 / Q000096:biosynthesis / Q000235:genetics
chemical_list: C477526:IL17RD protein, human; C518320:Il17rd protein, rat; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; D018123:Receptors, Interleukin; D053722:Receptors, Interleukin-17; C404992:Spry2 protein, rat