Colloidal microgels in drug delivery applications.
Colloidal microgels have recently received attention as environmentally responsive systems and now are increasingly used in applications as carriers for therapeutic drugs and diagnostic agents. Synthetic microgels consist of a crosslinked polymer network that provides a depot for loaded drugs, protection against environmental hazards and template for post-synthetic modification or vectorization of the drug carriers. The aim of this manuscript is to review recent attempts to develop new microgel formulations for oral drug delivery, to design metal-containing microgels for diagnostic and therapeutic applications, and to advance approaches including the systemic administration of microgels. Novel nanogel drug delivery systems developed in the authors' laboratory are discussed in details including aspects of their synthesis, vectorization and recent applications for encapsulation of low molecular weight drugs or formulation of biological macromolecules. The findings reviewed here are encouraging for further development of the nanogels as intelligent drug carriers with such features as targeted delivery and triggered drug release.
Vinogradov
Serguei V
SV
Center for Drug Delivery and Nanomedicine and Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, NE 68198, USA. vinograd@unmc.edu
D000284:Administration, Oral; D000818:Animals; D002626:Chemistry, Pharmaceutical; D003102:Colloids; D004247:DNA / Q000737:chemistry / Q000378:metabolism; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D004339:Drug Compounding; D016503:Drug Delivery Systems; D006801:Humans; D020100:Hydrogels / Q000737:chemistry*; D008670:Metals / Q000737:chemistry; D009077:Mucins / Q000737:chemistry; D000080385:Nanogels; D036103:Nanotechnology; D004364:Pharmaceutical Preparations / Q000008:administration & dosage / Q000737:chemistry / Q000378:metabolism; D011092:Polyethylene Glycols / Q000138:chemical synthesis*; D011094:Polyethyleneimine / Q000138:chemical synthesis*; D011108:Polymers / Q000737:chemistry*; D012995:Solubility; D000267:Tissue Adhesions; D014162:Transfection / Q000379:methods
D003102:Colloids; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D020100:Hydrogels; D008670:Metals; D009077:Mucins; D000080385:Nanogels; D004364:Pharmaceutical Preparations; D011108:Polymers; C413692:polyethylene glycol polyethyleneimine nanogel; D011092:Polyethylene Glycols; D011094:Polyethyleneimine; D004247:DNA