title: Effects of simultaneous hepatic resection on healing of left-sided colonic anastomoses: an experimental study in rats.
abstract: BACKGROUND
  A combined colorectal and hepatic resection is considered too risky by many surgeons owing to the high risk of postoperative septic complications. The aim of the present study was to investigate the effects of hepatic resection on the healing of left-sided colonic anastomoses in rats on postoperative day 7.
  
  
  METHODS
  Fifty-four Sprague-Dawley rats were block-randomized into three groups. In each group, 1 cm of the left side of the colon was resected and anastomosed. Additionally, 40 or 70% of the liver was resected in group 2 and 3, respectively. Rats were killed on postoperative day 7. The abdominal cavity was inspected for the presence of complications. The bursting pressure and hydroxyproline content of the anastomoses were measured.
  
  
  RESULTS
  The total number of complications was significantly higher in group 3 than in group 2. Anastomotic bursting pressure and hydroxyproline content did not differ significantly among the groups.
  
  
  CONCLUSIONS
  Increasing the extent of simultaneous hepatic resection did not significantly affect the healing of left-sided colonic anastomoses in rats on postoperative day 7, although there was a tendency towards lower bursting pressure paralleling the extent of liver resection. Excessive hepatic resection with colectomy may increase postoperative complications.
authors.affiliation: Department of Surgery, Jichi Medical School, Tochigi, Japan. h-ssnm@jichi.ac.jp
authors.forename: Hideki
authors.initials: H
authors.lastname: Sasanuma
authors.forename: Frank Viborg
authors.initials: FV
authors.lastname: Mortensen
authors.forename: Masanobu
authors.initials: M
authors.lastname: Hyodo
authors.forename: Masaki
authors.initials: M
authors.lastname: Okada
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Yasuda
authors.forename: Peter
authors.initials: P
authors.lastname: Funch-Jensen
authors.forename: Hideo
authors.initials: H
authors.lastname: Nagai
mesh_terms: D000597:Amino Acids, Branched-Chain / Q000378:metabolism; D000714:Anastomosis, Surgical / Q000401:mortality*; D000818:Animals; D001835:Body Weight; D003082:Colectomy / Q000401:mortality; D003106:Colon / Q000378:metabolism / Q000601:surgery*; D006498:Hepatectomy / Q000401:mortality*; D006909:Hydroxyproline / Q000378:metabolism; D008099:Liver / Q000601:surgery*; D008297:Male; D009017:Morbidity; D011183:Postoperative Complications / Q000401:mortality; D011312:Pressure; D051381:Rats; D017207:Rats, Sprague-Dawley; D014945:Wound Healing
chemical_list: D000597:Amino Acids, Branched-Chain; D006909:Hydroxyproline