title: Umbilical serum concentrations of chemokines (RANTES and MGSA/GRO-alpha) in preterm and term neonates.
abstract: BACKGROUND
  The objective of this study was to explore the relationship between labor (preterm and term) and umbilical blood serum regulated on activation, normal T cell expressed and secreted (RANTES) and melanoma growth stimulatory activity/growth-related oncogene-a (MSGA/GRO-alpha) concentration, and to determine whether early sepsis and pneumonia are associated with changes in concentrations of the chemokines (RANTES and MSGA/GRO-alpha) in umbilical blood serum.
  
  
  METHODS
  Umbilical blood was obtained from 67 neonates in the following groups: (i) preterm neonates with early sepsis; (ii) preterm neonates with pneumonia; (iii) non-infected preterm neonates; and (iv) full-term healthy neonates. RANTES and MGSA/GRO-alpha concentrations were determined by use of a commercially available immunoassay kit.
  
  
  RESULTS
  Non-infected preterm neonates had lower RANTES concentrations than healthy term neonates. Preterm infected neonates (pneumonia or sepsis) did not have higher RANTES concentrations than non-infected preterm neonates. In contrast, non-infected preterm neonates had higher MSGA/GRO-alpha concentrations than full-term healthy neonates. And preterm neonates with sepsis had higher MGSA/GRO-alpha concentrations than preterm ones with pneumonia and non-infected preterm ones.
  
  
  CONCLUSIONS
  Preterm neonates had constitutively lower RANTES concentrations than term ones and it seems that during infection RANTES concentrations did not increase. MGSA/GRO-a concentrations were constitutively higher in preterm than term neonates, and septic events further increased its concentrations in preterm neonates.
authors.affiliation: Department of Perinatology, Medical University of Silesia, Chorzow, Poland. olejnik@pik-net.pl
authors.forename: Barbara
authors.initials: B
authors.lastname: Królak-Olejnik
authors.forename: Brygida
authors.initials: B
authors.lastname: Beck
authors.forename: Igor
authors.initials: I
authors.lastname: Olejnik
mesh_terms: D016470:Bacteremia / Q000097:blood; D016022:Case-Control Studies; D018946:Chemokine CCL5 / Q000097:blood*; D054360:Chemokine CXCL1; D019743:Chemokines, CXC / Q000097:blood*; D005312:Fetal Blood / Q000737:chemistry*; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000097:blood*; D010500:Perinatology; D011014:Pneumonia / Q000097:blood*; D012189:Retrospective Studies
chemical_list: C475829:CXCL1 protein, human; D018946:Chemokine CCL5; D054360:Chemokine CXCL1; D019743:Chemokines, CXC