[The retinoid acid injected into sub retinal space couldn't reverse the retinal degeneration of mouse].
OBJECTIVE
To study the prevention of retinoid acid (RA) to the retinal degeneration when being injected into sub retinal space.


METHODS
10(-3) mol/L RA and phosphate buffered saline (PBS) were injected into the sub retinal space of 8 retinal degeneration (rd) mice respectively. The eye was analysed under microscopy one month after injection. 12 rd mice sorted as 4 groups were contrast; there were 3 rd mice whose mouse age was 7, 14, 28 days and 3 months respectively in each group.


RESULTS
The cells in inner nucleus layer had proliferated very much in part of tested eyes at one month. There were no difference between group RA and group PBS.


CONCLUSIONS
The degeneration of retina couldn't be stopped and the degenerated retina couldn't be restored to normal through the injection RA into the sub retinal space of rd mouse.
Zhang
Liang
L
Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China.
Tang
Shibo
S
Huang
Bing
B
Chen
Xigu
X
Lai
Yingrong
Y
D000287:Administration, Topical; D000818:Animals; D051379:Mice; D008809:Mice, Inbred C3H; D012160:Retina / Q000473:pathology; D012162:Retinal Degeneration / Q000188:drug therapy*; D014212:Tretinoin / Q000008:administration & dosage*
D014212:Tretinoin