title: Dectin-1 is required for beta-glucan recognition and control of fungal infection.
abstract: Beta-glucan is one of the most abundant polysaccharides in fungal pathogens, yet its importance in antifungal immunity is unclear. Here we show that deficiency of dectin-1, the myeloid receptor for beta-glucan, rendered mice susceptible to infection with Candida albicans. Dectin-1-deficient leukocytes demonstrated significantly impaired responses to fungi even in the presence of opsonins. Impaired leukocyte responses were manifested in vivo by reduced inflammatory cell recruitment after fungal infection, resulting in substantially increased fungal burdens and enhanced fungal dissemination. Our results establish a fundamental function for beta-glucan recognition by dectin-1 in antifungal immunity and demonstrate a signaling non-Toll-like pattern-recognition receptor required for the induction of protective immune responses.
authors.affiliation: Sir William Dunn School of Pathology, University of Oxford, Oxford OX13RE, UK.
authors.forename: Philip R
authors.initials: PR
authors.lastname: Taylor
authors.forename: S Vicky
authors.initials: SV
authors.lastname: Tsoni
authors.forename: Janet A
authors.initials: JA
authors.lastname: Willment
authors.forename: Kevin M
authors.initials: KM
authors.lastname: Dennehy
authors.forename: Marcela
authors.initials: M
authors.lastname: Rosas
authors.forename: Helen
authors.initials: H
authors.lastname: Findon
authors.forename: Ken
authors.initials: K
authors.lastname: Haynes
authors.forename: Chad
authors.initials: C
authors.lastname: Steele
authors.forename: Marina
authors.initials: M
authors.lastname: Botto
authors.forename: Siamon
authors.initials: S
authors.lastname: Gordon
authors.forename: Gordon D
authors.initials: GD
authors.lastname: Brown
mesh_terms: D000818:Animals; D002175:Candida / Q000276:immunology*; D002177:Candidiasis / Q000276:immunology* / Q000517:prevention & control; D005260:Female; D020022:Genetic Predisposition to Disease; D037181:Lectins, C-Type; D007962:Leukocytes / Q000276:immunology; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D051379:Mice; D018345:Mice, Knockout; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D047071:beta-Glucans / Q000276:immunology* / Q000378:metabolism; D000099181:Dectin-1
chemical_list: D037181:Lectins, C-Type; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; D047071:beta-Glucans; D000099181:Dectin-1