title: Computational analysis of blood flow in an integrated model of the left ventricle and the aorta.
abstract: To study the effects of intraventricular flow dynamics on the aortic flow, we created an integrated model of the left ventricle and aorta and conducted a computer simulation of diastolic and systolic blood flow within this model. The results demonstrated that the velocity profile at the aortic annulus changed dynamically, and was influenced by the intraventricular flow dynamics. The profile was almost flat in early systole but became nonuniform as systole progressed, and was skewed toward the posterior side in midsystole and toward the anterior side in later systole. At a distance from the aortic annulus, a different velocity profile was induced by the twisting and torsion of the aorta. In the ascending aorta, the fastest flow was initially located in the posteromedial sector, and it moved to the posterior section along the circumference as systole progressed. The nonuniformity of the aortic inflow gave rise to a complex wall shear stress (WSS) distribution in the aorta. A comparison of the WSS distribution obtained in this integrated analysis with that obtained in flow calculations using an isolated aorta model with Poiseuille and flat inlet conditions showed that intraventricular flow affected the WSS distribution in the ascending aorta. These results address the importance of an integrated analysis of flow in the left ventricle and aorta.
authors.affiliation: Department of Bioengineering and Robotics, Physiological Flow Studies Laboratory, Graduate School of Engineering, Tohoku University, Aoba 01, Sendai 980-8579, Japan. masanorin@pfsl.mech.tohoku.ac.jp
authors.forename: Masanori
authors.initials: M
authors.lastname: Nakamura
authors.forename: Shigeo
authors.initials: S
authors.lastname: Wada
authors.forename: Takami
authors.initials: T
authors.lastname: Yamaguchi
mesh_terms: D000818:Animals; D001011:Aorta / Q000502:physiology*; D001783:Blood Flow Velocity / Q000502:physiology*; D003198:Computer Simulation; D004548:Elasticity; D006801:Humans; D008955:Models, Cardiovascular; D033081:Shear Strength; D018511:Systems Integration; D013599:Systole / Q000502:physiology*; D016276:Ventricular Function