Solid-state characterization of two polymorphic forms of R-albuterol sulfate.
R-albuterol (levalbuterol) is a drug used for asthma therapy and some formulations of it are in solid dosage forms. The aim of this work was to describe and characterize two polymorphic modifications of R-albuterol sulfate by means of typical structure-sensitive analytical techniques such as X-ray powder diffraction, FT-IR spectroscopy, visual and microscopic inspection, and DSC. Substantial differences were observed between the solid-state properties of the crystals, confirming the existence of at least two polymorphic forms for R-albuterol sulfate: Form I and Form II.
Palacio
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MA
Agencia Córdoba Ciencia SE, Unidad CEPROCOR, Santa María de Punilla 5164, Córdoba, Argentina.
Cuffini
S
S
Badini
R
R
Karlsson
A
A
Palacios
S M
SM
D000420:Albuterol / Q000737:chemistry*; D001993:Bronchodilator Agents / Q000737:chemistry*; D002152:Calorimetry, Differential Scanning; D003460:Crystallization; D004355:Drug Stability; D008853:Microscopy / Q000379:methods; D015394:Molecular Structure; D011208:Powders; D017550:Spectroscopy, Fourier Transform Infrared; D014961:X-Ray Diffraction
D001993:Bronchodilator Agents; D011208:Powders; D000420:Albuterol