[Expressions of TGF-betaR I, Smad2, Smad3 and Smad7 in keloids].
OBJECTIVE
To investigate the expression of TGF-betaR I, Smad2, Smad3 and Smad7 in keloids, normal scars and normal skins. Discuss the significance of these proteins in the course of keloid.


METHODS
Immunohistochemistry method was used to detect the expression intensity and distribution of these proteins in above 3 kinds of different tissues in 44 cases. Statistics was used to analyze the data.


RESULTS
The expression of TGF-betaR I were much stronger in keloid than in the other two tissues. The expression of Smad7 were lower in keloids. The increase expression of Smad2,3 were not obvious, but they were found to accumulate in the nucleus.


CONCLUSIONS
The results indicate that over-expression of TGF-betaR I, low-expression of Smad7 and accumulation of Smad2,3 may be one of the etiological factors of keloids. This research may provide a new idea to prevent and treat keloids or other fibrosis diseases in the future.
Sun
Yi
Y
Department of Plastic Surgery, Zhejiang Provincial People's Hospital, Hangzhou 310014, China.
Song
Jian-xing
JX
Wang
Zi-min
ZM
Chen
Jiang-ping
JP
Chen
Ying
Y
Tan
Xiao-jie
XJ
Bai
Jin
J
D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D007627:Keloid / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D000077293:Receptor, Transforming Growth Factor-beta Type I; D018125:Receptors, Transforming Growth Factor beta / Q000378:metabolism*; D051899:Smad2 Protein / Q000378:metabolism*; D051900:Smad3 Protein / Q000378:metabolism*; D051906:Smad7 Protein / Q000378:metabolism*; D055815:Young Adult
D018125:Receptors, Transforming Growth Factor beta; D051899:Smad2 Protein; D051900:Smad3 Protein; D051906:Smad7 Protein; D017346:Protein Serine-Threonine Kinases; D000077293:Receptor, Transforming Growth Factor-beta Type I