Serotonin's SOS signal.
Neurotransmitters relay signals within the brain and to peripheral tissues, allowing communication between nerve cells. New work from in this issue of Cell Metabolism reveals that, in C. elegans, serotonin functions during conditions of stress through the well-characterized insulin/IGF-1 signaling pathway, suggesting a mechanism for the stress response.
Tissenbaum
Heidi A
HA
Program in Gene Function and Expression and Program in Molecular Medicine, University of Massachusetts Medical School, Aaron Lazare Research Building Suite 615, 364 Plantation Street, Worcester, Massachusetts 01605, USA.
D021581:Active Transport, Cell Nucleus / Q000235:genetics; D000818:Animals; D030801:Animals, Genetically Modified; D017173:Caenorhabditis elegans / Q000235:genetics / Q000378:metabolism*; D029742:Caenorhabditis elegans Proteins / Q000235:genetics / Q000378:metabolism*; D002467:Cell Nucleus / Q000235:genetics / Q000378:metabolism; D005473:Fluoxetine / Q000494:pharmacology; D051858:Forkhead Transcription Factors / Q000235:genetics / Q000378:metabolism; D023421:Models, Animal; D009154:Mutation; D009474:Neurons / Q000378:metabolism*; D009490:Neurosecretory Systems / Q000378:metabolism; D017526:Receptor, IGF Type 1 / Q000235:genetics / Q000276:immunology; D011972:Receptor, Insulin / Q000235:genetics / Q000378:metabolism; D012701:Serotonin / Q000235:genetics / Q000378:metabolism*; D017367:Selective Serotonin Reuptake Inhibitors / Q000494:pharmacology; D015398:Signal Transduction / Q000187:drug effects; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*
D029742:Caenorhabditis elegans Proteins; D005473:Fluoxetine; D051858:Forkhead Transcription Factors; D017526:Receptor, IGF Type 1; D011972:Receptor, Insulin; D012701:Serotonin; D017367:Selective Serotonin Reuptake Inhibitors; D014157:Transcription Factors; C108831:daf-16 protein, C elegans; C107483:DAF-2 protein, C elegans