Hyponatremia, hypophosphatemia, and hypouricemia in a girl with macrophage activation syndrome.
Macrophage activation syndrome, a life-threatening complication of rheumatic disorders, is accompanied by the overproduction of cytokines. We describe a girl with macrophage activation syndrome complicating systemic-onset juvenile arthritis who developed hyponatremia, hypophosphatemia, and hypouricemia associated with a high level of serum tumor necrosis factor alpha. Renal proximal tubule dysfunction was considered to be the cause, which may be attributable to tumor necrosis factor alpha.
Yamazawa
Kazuki
K
Department of Pediatrics, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.
Kodo
Kazuki
K
Maeda
Jun
J
Omori
Sayu
S
Hida
Mariko
M
Mori
Tetsuya
T
Awazu
Midori
M
D005260:Female; D006801:Humans; D007010:Hyponatremia / Q000209:etiology*; D017674:Hypophosphatemia / Q000209:etiology*; D007223:Infant; D008262:Macrophage Activation; D008659:Metabolic Diseases / Q000097:blood / Q000209:etiology*; D013577:Syndrome; D014527:Uric Acid / Q000097:blood*
D014527:Uric Acid