title: Pharmacokinetics and metabolism of 3,4-dichlorophenyl-propenoyl-sec.-butylamine in rats by high performance liquid chromatography-ion trap mass spectrometry.
abstract: The pharmacokinetics (PK) and metabolism of 3,4-dichlorophenyl-propenoyl-sec.-butylamine (3,4-DCPB), a novel antiepileptic drug, were investigated after its oral administration to rats (100 mg/kg) by HPLC. The absorption and elimination of 3,4-DCPB were rapid. 3,4-DCPB was found to undergo extensive metabolism as the major route of elimination. Structures of the metabolites present in rat plasma were identified with liquid chromatography-electrospray ionization-mass spectrometry (LC-ESI-MS/MS). It was concluded that 3,4-DCPB was involved in the multiple metabolic pathways (hydrolysis, dealkylation and oxidation) and the hydrolysis product, 3,4-dichloro-cinnamic acid (M1) appeared to be the major metabolite.
authors.affiliation: Department of Pharmacology, Basic Medical School, Beijing University, 38 Xue-Yuan Road, Beijing 100083, China.
authors.forename: Shu-Mei
authors.initials: SM
authors.lastname: Wang
authors.forename: Gui-Fang
authors.initials: GF
authors.lastname: Dou
authors.forename: Qiang
authors.initials: Q
authors.lastname: Li
authors.forename: Ting
authors.initials: T
authors.lastname: Liu
authors.forename: Zhi-Yun
authors.initials: ZY
authors.lastname: Meng
authors.forename: Ya-Qing
authors.initials: YQ
authors.lastname: Lou
authors.forename: Guo-Liang
authors.initials: GL
authors.lastname: Zhang
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000097:blood / Q000493:pharmacokinetics*; D002082:Butylamines / Q000097:blood / Q000493:pharmacokinetics*; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods*; D053719:Tandem Mass Spectrometry / Q000379:methods*
chemical_list: C521222:3,4-dichlorophenyl-propenoyl-sec-butylamine; D000927:Anticonvulsants; D002082:Butylamines