title: Assembly of 3-acyloxindoles via cui/L-proline-catalyzed intramolecular arylation of beta-keto amides.
abstract: [Structure: see text] Intramolecular coupling of beta-keto 2-iodoanilides catalyzed by CuI/L-proline in DMSO occurs at room temperature, affording substituted 3-acyloxindoles in good yield. Electronic effects on the aromatic ring have little influence on this reaction. Variations at the 1, 3, 4, 5, and 6 positions of the oxindoles were achieved by employing the corresponding amides.
authors.affiliation: Department of Chemistry, Fudan University, and State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai 200032, China.
authors.forename: Biao
authors.initials: B
authors.lastname: Lu
authors.forename: Dawei
authors.initials: D
authors.lastname: Ma
mesh_terms: D000577:Amides / Q000737:chemistry*; D002384:Catalysis; D007211:Indoles / Q000737:chemistry*; D011392:Proline / Q000737:chemistry*
chemical_list: D000577:Amides; D007211:Indoles; D011392:Proline