title: Regioselectively N-methylated azacalix[8]arene octamethyl ether prepared by catalytic aryl amination reaction using a temporal N-silylation protocol.
abstract: [Structure: see text] A temporal N-silylation protocol in the catalytic aryl amination reaction has been devised to prepare nitrogen-bridged calixarene analogues. The protocol involves a smooth in situ N-silylation before aryl amination reaction, followed by spontaneous cleavage of the N-Si bond in the usual workup process, to furnish secondary aromatic amines as the cross-coupled product with no silyl group on the nitrogen atom. A successful application to the preparation of regioselectively N-methylated azacalix[8]arene is described, together with the crystallographic analysis.
authors.affiliation: Graduate School of Human and Environmental Studies, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan.
authors.forename: Koichi
authors.initials: K
authors.lastname: Ishibashi
authors.forename: Hirohito
authors.initials: H
authors.lastname: Tsue
authors.forename: Satoshi
authors.initials: S
authors.lastname: Tokita
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Matsui
authors.forename: Hiroki
authors.initials: H
authors.lastname: Takahashi
authors.forename: Rui
authors.initials: R
authors.lastname: Tamura
mesh_terms: D000586:Amination; D002384:Catalysis; D008745:Methylation; D019158:N-Acetylneuraminic Acid / Q000737:chemistry*
chemical_list: D019158:N-Acetylneuraminic Acid