title: Meloxicam tolerance in hypersensitivity to nonsteroidal anti-inflammatory drugs.
abstract: BACKGROUND
  Patients with aspirin-sensitive respiratory and skin diseases experience cross reactions to all nonsteroidal anti-inflammatory drugs (NSAIDs) which inhibit cyclooxigenase (COX) enzymes. The need to identify an alternative drug that is safe and reliable is a common problem in clinical practice.
  
  
  OBJECTIVE
  The aim of this study was to test the tolerability of meloxicam in NSAID-sensitive patients.
  
  
  METHODS
  Between January 2005 and February 2006 we performed single-blind oral challenge tests with meloxicam in NSAID-intolerant patients, exposing them first to placebo and then, after 30 minutes, to the first dose of meloxicam (7.5 mg). After 30 minutes, if no response appeared, the last dose of meloxicam (15 mg) was given, for a total accumulated dose of 22.5 mg. The test was considered positive if urticaria, erythema. and/or angioedema appeared.
  
  
  RESULTS
  We tested 114 patients: 36% men and 64% women whose mean age was 45.81 years. Meloxicam was well tolerated in 109 of the 114 patients (95.62%) and only 5 (4.38%) developed an adverse reaction (urticaria in all cases).
  
  
  CONCLUSIONS
  This study shows that meloxicam can be a good option for NSAID-intolerant patients: it was safe for over 95% of the patients and is easier to obtain than celecoxib or etoricoxib. However, we think that a patient should be tested in an allergy unit before it is prescribed.
authors.affiliation: Unitat D'Allèrgia a Medicaments, Hospital Dos de Maig, Barcelona, Spain. 33940mvd@comb.es
authors.forename: M Viñas
authors.initials: MV
authors.lastname: Domingo
authors.forename: M J Castillo
authors.initials: MJ
authors.lastname: Marchuet
authors.forename: M T Dordal
authors.initials: MT
authors.lastname: Culla
authors.forename: R Serra
authors.initials: RS
authors.lastname: Joanpere
authors.forename: E Martí
authors.initials: EM
authors.lastname: Guadaño
mesh_terms: D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects* / Q000276:immunology; D001241:Aspirin / Q000009:adverse effects / Q000276:immunology; D052246:Cyclooxygenase 2 Inhibitors / Q000009:adverse effects* / Q000276:immunology; D004342:Drug Hypersensitivity; D005260:Female; D006801:Humans; D008297:Male; D000077239:Meloxicam; D008875:Middle Aged; D016037:Single-Blind Method; D013843:Thiazines / Q000009:adverse effects* / Q000276:immunology; D013844:Thiazoles / Q000009:adverse effects* / Q000276:immunology
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D052246:Cyclooxygenase 2 Inhibitors; D013843:Thiazines; D013844:Thiazoles; D001241:Aspirin; D000077239:Meloxicam