[Effects of risperidone on polysomnography in patients with first-episode schizophrenia].
OBJECTIVE
To investigate the effects of risperidone on the polysomnography (PSG) in the patients with first-episode schizophrenia.


METHODS
Twenty-five patients with first-episode schizophrenia, 13 males and 12 females, aged 29 +/- 8, underwent polysomnographic recording for 4 consecutive nights, the first night being used for acclimatization, and on the 3 rd and 4 th nights risperidone in the dose of 1.2 mg was administered before going to bed. Forty-four healthy persons, 23 males and 21 females, aged 28 +/- 8, underwent polysomnographic recording for 2 consecutive nights, the first night being used for acclimatization.


RESULTS
The baseline PSG recording showed that in comparison with the normal control group the total sleep time of the schizophrenia patients was shorter (378 min +/- 30 min vs 462 min +/- 21 min), sleep latency was longer (30 min +/- 14 min vs 18 min +/- 8 min), rapid eye movement (REM) sleep latency was shorter (59 min +/- 20 min vs 88 min +/- 10 min), REM sleep time was shorter (61 min +/- 17 min vs 84 min +/- 12 min), awakening time was longer (34 min +/- 17 min vs 15 min +/- 5 min), stage 1 (S1) time was longer (22% +/- 10% vs 9.0% +/- 1.7%), S3 time and S4 time were shorter, and the sleep efficacy was lower (86% +/- 10%) (P < 0.05 approximately P < 0.01); however, there was no significant difference in the S2 time between these 2 groups (54% +/- 16% vs 56% +/- 4%, P > 0.05). In the schizophrenia group, in comparison with the baseline levels in the third and fourth nights the total sleep times were significantly increased (406 min +/- 34 min and 428 min +/- 31 min respectively), the awakening times were significantly decreased (23 min +/- 15 min and 19 min +/- 8 min respectively), and S1 times were significantly decreased (14 min +/- 9 min and 10 min +/- 9 min respectively), with such changes time-dependently; and in the 4 th night the REM sleep time was significantly increased (87 min +/- 20 min) and the sleep efficacy was significantly improved (93% +/- 12%) (P < 0.05 approximately P < 0.01), however, there were no significant differences in the sleep latency and slow wave sleep (both P > 0.05).


CONCLUSIONS
Risperidone significantly improves the quality of sleep.
Chen
Xing-shi
XS
Department of Electrophysiology, Shanghai Institute of Mental Health, Shanghai, China.
Zhang
Ming-dao
MD
Lou
Fei-ying
FY
Wang
Hong-xing
HX
Wang
Ji-jun
JJ
Liang
Jian-hua
JH
Chen
Chong
C
Chen
Xin-wei
XW
Liu
Li
L
Gao
Cun-you
CY
Liu
Ping
P
Liu
Xiao-wei
XW
D000328:Adult; D014150:Antipsychotic Agents / Q000494:pharmacology / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017286:Polysomnography / Q000187:drug effects*; D018967:Risperidone / Q000494:pharmacology / Q000627:therapeutic use*; D012559:Schizophrenia / Q000188:drug therapy* / Q000503:physiopathology; D012890:Sleep / Q000187:drug effects; D013997:Time Factors
D014150:Antipsychotic Agents; D018967:Risperidone