title: A genomewide linkage analysis of Kawasaki disease: evidence for linkage to chromosome 12.
abstract: Kawasaki disease (KD) is an acute systemic vasculitis syndrome that primarily affects infants and young children. The cause of KD is largely unknown, but its higher incidence in the Asian population and increased risk in patients' families suggests the existence of underlying genetic factors. To determine the loci of a susceptibility gene for KD, a genomewide linkage analysis with affected sib pairs was performed on 78 family samples collected from all over Japan. Multipoint linkage analysis using MAPMAKER/SIBS 2.0 identified evidence of linkage on 12q24 [maximum lod score (MLS) = 2.69]. Possible linkage (MLS > 1.0) was also found on 4q35, 5q34, 6q27, 7p15, 8q24, 18q23, 19q13, Xp22, and Xq27. This is the first large-scale study of the genetic susceptibility to KD, and our results, combined with the accumulated knowledge of the human genome, could greatly promote research on identification of the molecular pathogenesis of KD.
authors.affiliation: Laboratory for Gastrointestinal Diseases, SNP Research Center, RIKEN, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa, 230-0045, Japan. onouchi@src.riken.jp.
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Onouchi
authors.affiliation: Laboratory for Genetics of Allergic Diseases, SNP Research Center, RIKEN, Yokohama, Japan.
authors.forename: Mayumi
authors.initials: M
authors.lastname: Tamari
authors.affiliation: Laboratory for Statistical Analysis, SNP Research Center, RIKEN, Tokyo, Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Takahashi
authors.affiliation: Laboratory for Medical Informatics, SNP Research Center, RIKEN, Yokohama, Japan.
authors.forename: Tatsuhiko
authors.initials: T
authors.lastname: Tsunoda
authors.affiliation: Department of Public Health, Jichi Medical School, Minamikawachi, Tochigi, Japan.
authors.forename: Mayumi
authors.initials: M
authors.lastname: Yashiro
authors.affiliation: Department of Public Health, Jichi Medical School, Minamikawachi, Tochigi, Japan.
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Nakamura
authors.affiliation: Saitama Prefectural University, Koshigaya, Saitama, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yanagawa
authors.affiliation: Department of Preventive Medicine, Shinshu University School of Medicine, Matsumoto, Japan.
authors.forename: Keiko
authors.initials: K
authors.lastname: Wakui
authors.affiliation: Department of Preventive Medicine, Shinshu University School of Medicine, Matsumoto, Japan.
authors.forename: Yoshimitsu
authors.initials: Y
authors.lastname: Fukushima
authors.affiliation: Japan Kawasaki Disease Research Center, Tokyo, Japan.
authors.forename: Tomisaku
authors.initials: T
authors.lastname: Kawasaki
authors.affiliation: Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Nakamura
authors.affiliation: Laboratory for Gastrointestinal Diseases, SNP Research Center, RIKEN, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa, 230-0045, Japan.|Department of Public Health, Chiba University Graduate School of Medicine, Chiba, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Hata
mesh_terms: D002874:Chromosome Mapping; D002881:Chromosomes, Human, Pair 12 / Q000235:genetics*; D005190:Family; D005260:Female; D008040:Genetic Linkage; D015894:Genome, Human; D005838:Genotype; D006801:Humans; D008297:Male; D009080:Mucocutaneous Lymph Node Syndrome / Q000235:genetics*