[The influence of ACE-inhibitor on endothelin concentration and some metabolic parameters in young hypertensives].
The aim of this study was to assess the influence of trandolapril on blood pressure and ET-1 plasma activity in young patients with essential mild-to-moderate hypertension.


METHODS
19 persons with essential mild-to-moderate hypertension were enrolled into the study: the average age of this group was 17,6 +/- 1,4 years. The blood pressure and serum concentration of ET-1 in plasma were measured before enrolling and after 42 days of trandolapril (2 mg per day) therapy. The concentration of endothelin-1 was measured using RIA method.


RESULTS
In the studied group, after trandolapril therapy SBP was reduced from 142.6 +/- 9,7 mmHg to 129.3 +/- 8,4 mmHg (p<0,003), DBP from 85.7 +/- 6,9 mmHg to 79.8 +/- 8,6 mmHg (p<0,01). The average serum concentration of endothelin-1 was: before therapy 9,33 +/- 1,9 fmol/ml and after therapy 8,96 +/- 2,2 fmol/ml (non-significant).


CONCLUSIONS
1. Young hypertensives treated with trandolapril (ACEI) showed significant decrease of SBP and DBP 2. 6-weeks trandolapril therapy was associated with the reduction of serum concentration of ET-1, but without statistical significance.
Bryl
Wiesław
W
Akademia Medyczna w Poznaniu, Katedra i Klinika Chorób Wewnetrznych, Zaburzeń Metabolicznych i Nadciśnienia Tetniczego. wieslawbryl@wp.pl
Pupek-Musialik
Danuta
D
D000293:Adolescent; D000328:Adult; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D019332:Endothelin-1 / Q000097:blood* / Q000187:drug effects; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000378:metabolism*; D007211:Indoles / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D016896:Treatment Outcome
D000806:Angiotensin-Converting Enzyme Inhibitors; D019332:Endothelin-1; D007211:Indoles; C052035:trandolapril