Synthesis and alternate-stranded triple helix forming ability of novel anthraquinone modified alpha-beta chimeric DNA.
A series of novel alpha-beta chimeric oligonucleotides bearing an anthraquinone-conjugated non-nucleosidic backbone were synthesized as a triplex-forming oligonucleotide (TFO). UV-melting experiments revealed that the obtained modified chimera TFOs form remarkably stable alternate-stranded triplex almost regardless to the stereochemistry of the incorporated non-nucleosidic backbone unit.
Moriguchi
Tomohisa
T
Department of Chemistry, Gunma University, 1-5-1 Tenjincho, Kiryu, Gunma 376-8515, Japan.
Azam
A T M Zafrul
AT
Shinozuka
Kazuo
K
D000880:Anthraquinones / Q000737:chemistry*; D004247:DNA / Q000737:chemistry*; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis / Q000737:chemistry*; D013237:Stereoisomerism
D000880:Anthraquinones; D009838:Oligodeoxyribonucleotides; C051802:triplex DNA; D004247:DNA