title: A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes.
abstract: Recent studies suggest that thousands of genes may contribute to breast cancer pathophysiologies when deregulated by genomic or epigenomic events. Here, we describe a model "system" to appraise the functional contributions of these genes to breast cancer subsets. In general, the recurrent genomic and transcriptional characteristics of 51 breast cancer cell lines mirror those of 145 primary breast tumors, although some significant differences are documented. The cell lines that comprise the system also exhibit the substantial genomic, transcriptional, and biological heterogeneity found in primary tumors. We show, using Trastuzumab (Herceptin) monotherapy as an example, that the system can be used to identify molecular features that predict or indicate response to targeted therapies or other physiological perturbations.
authors.affiliation: Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94270, USA. rmneve@lbl.gov
authors.forename: Richard M
authors.initials: RM
authors.lastname: Neve
authors.forename: Koei
authors.initials: K
authors.lastname: Chin
authors.forename: Jane
authors.initials: J
authors.lastname: Fridlyand
authors.forename: Jennifer
authors.initials: J
authors.lastname: Yeh
authors.forename: Frederick L
authors.initials: FL
authors.lastname: Baehner
authors.forename: Tea
authors.initials: T
authors.lastname: Fevr
authors.forename: Laura
authors.initials: L
authors.lastname: Clark
authors.forename: Nora
authors.initials: N
authors.lastname: Bayani
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Coppe
authors.forename: Frances
authors.initials: F
authors.lastname: Tong
authors.forename: Terry
authors.initials: T
authors.lastname: Speed
authors.forename: Paul T
authors.initials: PT
authors.lastname: Spellman
authors.forename: Sandy
authors.initials: S
authors.lastname: DeVries
authors.forename: Anna
authors.initials: A
authors.lastname: Lapuk
authors.forename: Nick J
authors.initials: NJ
authors.lastname: Wang
authors.forename: Wen-Lin
authors.initials: WL
authors.lastname: Kuo
authors.forename: Jackie L
authors.initials: JL
authors.lastname: Stilwell
authors.forename: Daniel
authors.initials: D
authors.lastname: Pinkel
authors.forename: Donna G
authors.initials: DG
authors.lastname: Albertson
authors.forename: Frederic M
authors.initials: FM
authors.lastname: Waldman
authors.forename: Frank
authors.initials: F
authors.lastname: McCormick
authors.forename: Robert B
authors.initials: RB
authors.lastname: Dickson
authors.forename: Michael D
authors.initials: MD
authors.lastname: Johnson
authors.forename: Marc
authors.initials: M
authors.lastname: Lippman
authors.forename: Stephen
authors.initials: S
authors.lastname: Ethier
authors.forename: Adi
authors.initials: A
authors.lastname: Gazdar
authors.forename: Joe W
authors.initials: JW
authors.lastname: Gray
mesh_terms: D001943:Breast Neoplasms / Q000145:classification* / Q000235:genetics* / Q000473:pathology / Q000628:therapy; D045744:Cell Line, Tumor; D005260:Female; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D023281:Genomics; D006801:Humans; D009363:Neoplasm Proteins / Q000032:analysis
chemical_list: D009363:Neoplasm Proteins