title: Inflammatory myofibroblastic tumor of the larynx with anaplastic lymphoma kinase (ALK) protein overexpression. A case report.
abstract: Inflammatory myofibroblastic tumor is an uncommon lesion which mainly develops in the lung and is extremely rare in the larynx. It may be easily misinterpreted as a malignant epithelial or mesenchymal spindle cell neoplasm. Histological and clinical knowledge of this lesion is important to exclude misdiagnosis and inappropriate treatment. We report a case of inflammatory myofibroblastic tumor arising on the right vocal cord of a 23-year-old man. The tumor was composed of a mixture of spindle cells and inflammatory elements. Immunohistochemical investigation revealed that the neoplastic cells expressed anaplastic lymphoma kinase (ALK) protein.
authors.affiliation: Institute of Pathologic Anatomy and Histology, Division of Cancer Research, Perugia Medical School, University of Perugia, Perugia, Italy. guidobellezza@virgilio.it
authors.forename: Guido
authors.initials: G
authors.lastname: Bellezza
authors.forename: Antonio
authors.initials: A
authors.lastname: Cavaliere
authors.forename: Rachele
authors.initials: R
authors.lastname: Del Sordo
authors.forename: Angelo
authors.initials: A
authors.lastname: Sidoni
mesh_terms: D000328:Adult; D000077548:Anaplastic Lymphoma Kinase; D015971:Gene Expression Regulation, Enzymologic; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007150:Immunohistochemistry; D007249:Inflammation / Q000201:enzymology; D007822:Laryngeal Neoplasms / Q000201:enzymology* / Q000473:pathology; D008297:Male; D009379:Neoplasms, Muscle Tissue / Q000201:enzymology* / Q000473:pathology; D011505:Protein-Tyrosine Kinases / Q000378:metabolism*; D020794:Receptor Protein-Tyrosine Kinases; D015854:Up-Regulation
chemical_list: C000626173:ALK protein, human; D000077548:Anaplastic Lymphoma Kinase; D011505:Protein-Tyrosine Kinases; D020794:Receptor Protein-Tyrosine Kinases