The limits of disclosure: what research subjects want to know about investigator financial interests.
Research participants' views about investigator financial interests were explored. Reactions ranged from concern to acceptance, indifference, and even encouragement. Although most wanted such information, some said it did not matter, was private, or was burdensome, and other factors were more important to research decisions. Very few said it would affect their research decisions, and many assumed that institutions managed potential conflicts of interest. Although disclosure of investigator financial interest information to research participants is often recommended, its usefulness is limited, especially when participation is desired because of illness.
Grady
Christine
C
Section on Human Subjects Research, Department ofClinical Bioethics, Clinical Center, NIH, USA.
Horstmann
Elizabeth
E
Sussman
Jeffrey S
JS
Hull
Sara Chandros
SC
D001294:Attitude to Health; D035843:Biomedical Research / Q000191:economics* / Q000941:ethics; D016265:Conflict of Interest / Q000191:economics*; D003657:Decision Making; D030881:Disclosure / Q000941:ethics*; D028744:Ethics Committees, Research / Q000191:economics* / Q000941:ethics; D006801:Humans; D007258:Informed Consent; D007407:Interviews as Topic; D036301:Qualitative Research; D035842:Research Subjects / Q000523:psychology*; D012109:Research Support as Topic; D036302:Therapeutic Human Experimentation / Q000191:economics / Q000941:ethics; D035502:Trust; D014481:United States