Linkage of schizophrenia with chromosome 1q32 in Korean multiplex families.
Chromosome 1q contains a few loci for which modest evidence of linkage with schizophrenia has been reported in several independent studies. However, markers showing the peak linkage signal are dispersed over a large chromosomal region. In addition, inconsistent findings have been generated from different populations or different subgroups of the same populations. The purpose of the current study is to determine whether those loci are linked to schizophrenia in the Korean population. We investigated 46 Korean multiplex schizophrenia families, initially using 11 microsatellite markers spanning around 91 cM region of 1p22 approximately 42. In a non-parametric linkage analysis, D1S249 located on 1q32.1 showed statistical evidence suggestive of linkage. At the second stage analysis for narrowing down the region, four additional nearby markers were genotyped. In the single point analysis, we found another suggestive linkage signal at D1S2891. The highest NPL score of 2.67 (P = 0.0039) was obtained in the multi-point analysis. This study provides supportive evidence for linkage of chromosome 1q32 with schizophrenia.
Jang
Yong Lee
YL
Department of Psychiatry, Samsung Medical Center, Sungkyunkwan University School of Medicine, Kagnam-Gu, Seoul, Korea.
Kim
Jong Won
JW
Lee
Yu-Sang
YS
Park
Dong Yeon
DY
Cho
Eun-Young
EY
Jeun
Hyun Ok
HO
Lee
Dongsoo
D
Hong
Kyung Sue
KS
D002878:Chromosomes, Human, Pair 1; D005190:Family; D008040:Genetic Linkage; D005838:Genotype; D006801:Humans; D007723:Korea; D008126:Lod Score; D018895:Microsatellite Repeats; D012559:Schizophrenia / Q000235:genetics*