title: [New drugs; nitisinone].
abstract: Nitisinone is an inhibitor of 4-hydroxyphenyl-pyruvate dioxygenase (4HPPD). Its rare area of use is hereditary tyrosinaemia, a life-threatening disease in which the last step in the catabolism of tyrosine cannot be taken due to the absence of an enzyme. The inhibition of 4HPPD, an enzyme that is active early in the catabolic cascade, prevents the accumulation of toxic metabolites of tyrosine.
authors.affiliation: Centre for Human Drug Research, Zernikedreef 10, 2333 CL Leiden. ac@chdr.nl
authors.forename: A F
authors.initials: AF
authors.lastname: Cohen
authors.forename: H
authors.initials: H
authors.lastname: van Bronswijk
mesh_terms: D003512:Cyclohexanones / Q000627:therapeutic use*; D004791:Enzyme Inhibitors / Q000627:therapeutic use*; D006801:Humans; D009579:Nitrobenzoates / Q000627:therapeutic use*; D014443:Tyrosine / Q000378:metabolism*; D020176:Tyrosinemias / Q000188:drug therapy* / Q000378:metabolism*
chemical_list: D003512:Cyclohexanones; D004791:Enzyme Inhibitors; D009579:Nitrobenzoates; D014443:Tyrosine; C077073:nitisinone