title: Expression of semaphorin 6D in gastric carcinoma and its significance.
abstract: OBJECTIVE
  To investigate the protein and mRNA expression of semaphorin 6D in gastric carcinoma and its significance.
  
  
  METHODS
  The protein and mRNA expression of semaphorin 6D was detected by semi-quantitative reverse transcription PCR and Western blotting respectively in 30 cases of gastric carcinoma and normal gastric mucosa.
  
  
  RESULTS
  The protein and mRNA expression of semaphorin 6D in gastric carcinoma was significantly higher than that in normal gastric mucosa (0.24 +/- 0.06 vs 0.19 +/- 0.07, 0.26 +/- 0.09 vs 0.20 +/- 0.10, P < 0.05).
  
  
  CONCLUSIONS
  Semaphorin 6D may play an important role in the occurrence and development of gastric carcinoma, and is related to tumor angiogenesis.
authors.affiliation: Department of General Surgery, General Hospital of Chinese PLA, 28 Fuxing Road, Beijing 100853, China.
authors.forename: Xiang-Yang
authors.initials: XY
authors.lastname: Zhao
authors.forename: Lin
authors.initials: L
authors.lastname: Chen
authors.forename: Qian
authors.initials: Q
authors.lastname: Xu
authors.forename: Yu-Hong
authors.initials: YH
authors.lastname: Li
mesh_terms: D000328:Adult; D000368:Aged; D002454:Cell Differentiation; D005260:Female; D005753:Gastric Mucosa / Q000473:pathology*; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008297:Male; D008875:Middle Aged; D009389:Neovascularization, Pathologic / Q000235:genetics; D012333:RNA, Messenger / Q000235:genetics; D012334:RNA, Neoplasm / Q000235:genetics; D039961:Semaphorins / Q000235:genetics*; D013274:Stomach Neoplasms / Q000235:genetics* / Q000473:pathology / Q000601:surgery
chemical_list: D012333:RNA, Messenger; D012334:RNA, Neoplasm; D039961:Semaphorins