Ultrastructural characteristics of type A epithelioid cells during BCG-granulomatosis and treatment with lysosomotropic isoniazid.
We studied BCG-granulomas, their cellular composition, and ultrastructure of type A epithelioid cells in the liver of male BALB/c mice with spontaneous granulomatous inflammation. The animals received free isoniazid or isoniazid conjugated with lysosomotropic intracellularly prolonged matrix (dialdehyde dextran, molecular weight 65-75 kDa). Lysosomotropic isoniazid was accumulated in the vacuolar apparatus of epithelioid cells and produced a stimulatory effect on plastic processes in these cells.
Shkurupii
V A
VA
Department of General Pathology, Research Center of Clinical and Experimental Medicine, Siberian Division of the Russian Academy of Medical Sciences. sck@soramn.ru
Kozyaev
M A
MA
Nadeev
A P
AP
D000447:Aldehydes / Q000494:pharmacology; D000818:Animals; D000995:Antitubercular Agents / Q000494:pharmacology*; D003911:Dextrans / Q000737:chemistry; D004847:Epithelial Cells / Q000187:drug effects* / Q000648:ultrastructure*; D006099:Granuloma / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D007249:Inflammation; D007538:Isoniazid / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects* / Q000382:microbiology / Q000648:ultrastructure; D008247:Lysosomes / Q000378:metabolism*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009163:Mycobacterium bovis / Q000378:metabolism*
D000447:Aldehydes; D000995:Antitubercular Agents; D003911:Dextrans; D007538:Isoniazid