Synthesis of purin-2-yl carboxylate from O6-methylguanosine.
O6-methylguanosine derivative was treated with sodium nitrite or isoamylnitrite in the presence of the carboxylic acid to give the purin-2-yl carboxylate (2), an unusual product bearing a carboxylic group at 2-position of purine moiety.
Maruyama
Tokumi
T
Faculty of Pharmaceutical Sciences at Kagawa Campus, Tokushima Bunri University, Shido 1314-1, Sanuki City, Kagawa 769-2193, Japan. maruyama@ph.bunri-u.ac.jp
Moriwaka
Nobuyasu
N
Demizu
Yosuke
Y
Ohtsuka
Masami
M
D006151:Guanosine / Q000031:analogs & derivatives* / Q000737:chemistry; D011684:Purine Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry
D011684:Purine Nucleosides; D006151:Guanosine; C046175:6'-O-methylguanosine