Copper(I)-catalyzed enantio- and diastereoselective tandem reductive aldol reaction.
[Structure: see text] An efficient method for the enantioselective tandem reductive aldol reaction of methyl acrylate with aldehydes is reported. By using a copper(I) precursor and a proper diphosphane ligand, high reactivities can be reached, with TOF up to 40,000 h-1. Taniaphos-based ligands lead to enantioselectivities of up to 97% in the case of the major syn diastereoisomer.
Chuzel
Olivier
O
Unité de chimie organique et médicinale, Université catholique de Louvain, Place Louis Pasteur, 1, 1348 Louvain-la-Neuve, Belgium.
Deschamp
Julia
J
Chausteur
Christophe
C
Riant
Olivier
O
D000447:Aldehydes / Q000737:chemistry; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D008024:Ligands; D013237:Stereoisomerism
D000447:Aldehydes; D008024:Ligands; D003300:Copper