title: [Tramadol-induced hypoglycemia. 2 cases].
abstract: BACKGROUND
  Tramadol has been approved in France since 1994 for the treatment of moderate to severe pain. The most commonly reported adverse effects involve the central nervous system and gastrointestinal tract. To our knowledge, hypoglycemia has not previously been reported.
  
  
  METHODS
  We report 2 cases of hypoglycemia related to tramadol, one in a nondiabetic 88-year-old woman, and the other in a diabetic 8-year-old girl. Hypoglycemia resolved after tramadol discontinuation.
  
  
  CONCLUSIONS
  The French Pharmacovigilance (Adverse Drug Reports) database includes several cases of hypoglycemia in patients receiving tramadol. Reports from the literature of dextropropoxyphene-induced hypoglycemia and a pharmacological study of tramadol in rats suggest that the micro opioid receptor is the principal target involved in this hypoglycemic mechanism.
authors.affiliation: Centre Régional de Pharmacovigilance, Pôle des Pathologies Lourdes et Vigilances, Dijon. aurelie.grandvuillemin@chu-dijon.fr
authors.forename: Aurélie
authors.initials: A
authors.lastname: Grandvuillemin
authors.forename: Geneviève
authors.initials: G
authors.lastname: Jolimoy
authors.forename: François
authors.initials: F
authors.lastname: Authier
authors.forename: Anne
authors.initials: A
authors.lastname: Dautriche
authors.forename: Fabienne
authors.initials: F
authors.lastname: Duhoux
authors.forename: Catherine
authors.initials: C
authors.lastname: Sgro
mesh_terms: D000284:Administration, Oral; D000368:Aged; D000369:Aged, 80 and over; D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000009:adverse effects*; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000150:complications; D005260:Female; D006801:Humans; D007003:Hypoglycemia / Q000139:chemically induced*; D013997:Time Factors; D014147:Tramadol / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D000701:Analgesics, Opioid; D014147:Tramadol