Does previous response to clomifene citrate influence the selection of gonadotropin dosage given in subsequent superovulation treatment cycles?
OBJECTIVE
To determine whether ovarian response to previous clomifene treatment could influence the selection of the starting dose of gonadotropins in subsequent in vitro fertilization (IVF) or intra uterine insemination (IUI).


METHODS
Forty three anovular women who had received clomifene for ovulation induction followed by gonadotropins for IUI or IVF superovulation were reviewed retrospectively. Data on gonadotropin dose were compared between clomifene-resistant patients and clomifene responders.


RESULTS
IVF patients who had had prior superovulation/IUI treatment received similar doses of gonadotropins regardless of response to clomifene (1610 IU versus 1560 IU, p = 0.74). In IVF patients not receiving prior IUI treatment, the clomifene-resistant women were given higher doses of gonadotropins than those responding to clomifene (2500 IU versus 1440 IU, p = 0.042).


CONCLUSIONS
We found that, in our Unit, clinicians appeared to use prior non-response to clomifene as a reason for prescribing a higher starting dose of gonadotropins in IVF treatment, a practice that is not evidence-based.
Nguyen
Tien Huu
TH
Academic Unit of Clinical Pharmacology, University of Sheffield, Sheffield, United Kingdom.
Lennard
Martin S
MS
Ghobadi
Cyrus
C
Rostami-Hodjegan
Amin
A
Ledger
William L
WL
D000858:Anovulation; D002996:Clomiphene / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004958:Estradiol / Q000097:blood; D005260:Female; D005300:Fertility Agents, Female / Q000627:therapeutic use*; D005307:Fertilization in Vitro / Q000379:methods; D006062:Gonadotropins / Q000627:therapeutic use*; D006801:Humans; D010060:Ovulation / Q000187:drug effects; D018579:Patient Selection; D013480:Superovulation
D005300:Fertility Agents, Female; D006062:Gonadotropins; D002996:Clomiphene; D004958:Estradiol