The pathophysiology of intracerebral haemorrhage.
Spontaneous intracerebral haemorrhage carries a high mortality rate and treatment of the disease raises more questions then answers. Mass effect, ischaemia and toxicity of blood components are responsible for brain tissue damage. Initially occurring disturbances of cerebral blood flow have a temporary character and do not play a key role in the pathology of intracerebral haematoma. Oedema formatting in the 24-48 hours after intracerebral bleeding is the result of multidirectional processes. The pathological mechanism that underlines it is the function of activation of systemic complement and cascade of coagulation. In the light of these findings, further clinical and experimental investigations should be focused on these factors.
Karwacki
Z
Z
Department of Neuroanaesthesiology, Medical University, Gdańsk, Poland. zkarw@amg.gda.pl
Kowiański
P
P
Witkowska
M
M
Karwacka
M
M
Dziewiatkowski
J
J
Moryś
J
J
D001777:Blood Coagulation / Q000502:physiology; D001812:Blood-Brain Barrier / Q000503:physiopathology; D001929:Brain Edema / Q000503:physiopathology; D002545:Brain Ischemia / Q000503:physiopathology; D002543:Cerebral Hemorrhage / Q000503:physiopathology*; D018450:Disease Progression; D006801:Humans; D009457:Neuroglia / Q000473:pathology