title: Immunohistochemical characterization of Kisselev nodules (ectopic lymphoid follicles) in wild boar (Sus scrofa L.).
abstract: This paper describes the histopathological features and cellular distribution of T lymphocytes (CD3), B cells (CD79), follicular dendritic cells (FDC) and macrophages (alpha-1-antitrypsin, lysozyme) in lymphoid aggregates (Kisselev nodules) found in the lung, kidney and liver of wild boar (Sus scrofa L.). The distribution of immunoreactive cells, tested for antibodies, was similar to that found in the cortex of lymph nodes: lymphoid follicles with germinal centers mainly consisting of CD79+ B cells with sparse interfollicular tissue (CD3+ T lymphocytes). This finding and the association of these structures with helminthic infections suggests that local humoral immunity is central to the organism's response to parasitic challenge. The presence of follicular dendritic cells confirms the high degree of organization of these lymphoid-like structures. The role of other pathogenic factors and the induction of chronic inflammatory reaction in these ectopic lymphoid sites is also discussed.
authors.affiliation: Department of Comparative Biomedical Sciences, Faculty of Veterinary Medicine, Teramo University, Piazza Aldo Moro 45, 64100 Teramo, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Palmieri
authors.forename: M
authors.initials: M
authors.lastname: Brunetti
authors.forename: L
authors.initials: L
authors.lastname: Della Salda
mesh_terms: D000818:Animals; D002828:Choristoma / Q000175:diagnosis / Q000662:veterinary*; D007150:Immunohistochemistry / Q000662:veterinary*; D007668:Kidney / Q000473:pathology; D008099:Liver / Q000473:pathology; D008168:Lung / Q000473:pathology; D008221:Lymphoid Tissue / Q000473:pathology*; D034421:Sus scrofa; D013553:Swine Diseases / Q000175:diagnosis*