Nonallergic rhinitis with eosinophilia syndrome and related disorders.
NARES is a clinical syndrome consisting of symptoms consistent with AR in which an absence of atopy has been demonstrated by allergen skin testing, with nasal cytology analysis showing greater than 20% eosinophils. Anosmia is a prominent feature not shared with AR. The pathophysiology of NARES is poorly understood, but a key component involves a self-perpetuating, chronic eosinophilic nasal inflammation with development of nasal micropolyposis and polyposis. Mast cells likely play an important role as well. NARES is a risk factor for the development of nasal polyposis and aspirin sensitivity, as well as obstructive sleep apnea. Treatment consists mainly of intranasal corticosteroids with or without the addition of second-generation antihistamines and/or LT receptor antagonists as an adjuvant.
Ellis
Anne K
AK
Department of Medicine, Division of Clinical Immunology and Allergy, McMaster University, Hamilton, Ontario, Canada.
Keith
Paul K
PK
D004802:Eosinophilia / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D006801:Humans; D009297:Nasal Mucosa / Q000473:pathology; D012220:Rhinitis / Q000145:classification / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D013577:Syndrome