A simple Tracerlab module modification for automated on-column [11C]methylation and [11C]carboxylation.
A modification of commercial [11C]methylation module which can be implemented for both on-column [11C]methylation and [11C]carboxylation in the same automated system is described. This module configuration was applied to the solid-phase synthesis of N-[11C]methyl-choline ([11C]choline) and L-(S-methyl-[11C])methionine ([11C]methionine), using [11C]CH(3)I as methylating agent, as well as to the synthesis of [11C]acetate by [11C]carboxylation with [11C]CO2 of methylmagnesium chloride with high and reproducible radiochemical yields in short reaction time, demonstrating to be a fast and reliable tool for the production of these [11C]radiopharmaceuticals for clinical use.
Lodi
Filippo
F
Nuclear Medicine Unit, S. Orsola Hospital, Bologna, Italy.
Trespidi
Silvia
S
Di Pierro
Donato
D
Marengo
Mario
M
Farsad
Mohsen
M
Fanti
Stefano
S
Franchi
Roberto
R
Boschi
Stefano
S
D019342:Acetic Acid / Q000138:chemical synthesis; D001331:Automation; D002250:Carbon Radioisotopes / Q000737:chemistry*; D002794:Choline / Q000138:chemical synthesis; D006801:Humans; D007202:Indicators and Reagents; D008715:Methionine / Q000138:chemical synthesis; D008745:Methylation; D049268:Positron-Emission Tomography; D011854:Radiochemistry / Q000295:instrumentation*; D019275:Radiopharmaceuticals / Q000138:chemical synthesis*
D002250:Carbon Radioisotopes; D007202:Indicators and Reagents; D019275:Radiopharmaceuticals; D008715:Methionine; D002794:Choline; D019342:Acetic Acid