Lovastatin possesses a fungistatic effect against Candida albicans, but does not trigger apoptosis in this opportunistic human pathogen.
Lovastatin inhibited the growth of Candida albicans in a fungistatic way. Although it triggers apoptosis in a great variety of eukaryotic cells, including many tumour cell lines, lovastatin failed to provoke apoptotic events in this human pathogen. The fungistatic behaviour of this statin might arise from its negative influence on membrane fluidity. Because yeast-->pseudomycelium and hyphae morphogenetic transitions took place under exposure to lovastatin morphogenetic switch and apoptotic cell death must be regulated independently in C. albicans.
Gyetvai
Agnes
A
Department of Microbiology and Biotechnology, Faculty of Science, University of Debrecen, Debrecen, Hungary.
Emri
Tamás
T
Takács
Krisztina
K
Dergez
Tímea
T
Fekete
Andrea
A
Pesti
Miklós
M
Pócsi
István
I
Lenkey
Béla
B
D000935:Antifungal Agents / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D002176:Candida albicans / Q000187:drug effects* / Q000254:growth & development; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D053938:DNA Fragmentation / Q000187:drug effects; D004271:DNA, Fungal / Q000187:drug effects; D006801:Humans; D008148:Lovastatin / Q000494:pharmacology*
D000935:Antifungal Agents; D004271:DNA, Fungal; D008148:Lovastatin