title: Verification of IACUC approval and the just-in-time PHS grant process.
abstract: Public Health Service Policy requires institutional animal care and use committees (IACUCs) to review and approve the animal care and use aspects of grant proposals submitted for funding. Initially, submission of verification of approval was required with submission of the proposal; however, in 2002, a ''just-in-time'' (JIT) process was begun to allow submission when it appeared that the proposal would be in the fundable range. After 3 yr, no evaluation of JIT and its impact on the IACUC has been published. An online survey designed by the authors to determine this impact is described. Invitations to participate in the survey were sent to 1002 IACUC chairs and administrators, and responses were received from 168. Surprisingly, 30% of respondents indicated that they did not review grant proposals at all. The majority of those respondents reported that they rely on principal investigator assurance that approved IACUC protocols match grant proposals. In the authors' experience, this procedure is not safe 23% of the time, and several respondents described the same experience. Most respondents indicated that they use JIT whenever possible for all investigators. Of those who reviewed grant proposals, most indicated that each review consumes 20 to 29 min, and most respondents indicated that the granting agency does not allow enough time for a JIT verification to complete a de novo submission and review of a protocol. Instead, the protocol must have been submitted and reviewed prior to the JIT request. Respondents indicated that there is considerable uncertainty about what the granting agency would do when an IACUC requires changes in a protocol during the JIT process.
authors.affiliation: Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE 68198-5850, USA. mmann@unmc.edu
authors.forename: Michael D
authors.initials: MD
authors.lastname: Mann
authors.forename: Ernest D
authors.initials: ED
authors.lastname: Prentice
mesh_terms: D035661:Animal Care Committees; D032761:Animal Experimentation; D000818:Animals; D000830:Animals, Laboratory; D005380:Financing, Government / Q000379:methods*; D006801:Humans; D012107:Research Design; D014481:United States; D014492:United States Public Health Service