Neuropharmacological properties of Xylocarpus moluccensis.
The methanolic extracts of the barks and pneumatophores of Xylocarpus moluccensis were assessed for their effects on the central nervous system (CNS) using a series of established pharmacological tests including pentobarbitone-induced sleeping time, open field, hole cross, hole-board and evasions tests in mice model. These extracts produced a dose-dependent reduction of the onset and duration of pentobarbitone-induced hypnosis, reduction of locomotor and exploratory activities in the open field, hole cross, head-dip and evasion tests. These results suggest that both the bark and pneumatophore extracts possess CNS depressant activity, the pneumatophore extract being more potent than the bark extract.
Sarker
Satyajit D
SD
School of Biomedical Sciences, University of Ulster at Coleraine, Cromore Road, Coleraine BT52 1SA, Co. Londonderry, Northern Ireland, UK. s.sarker@ulster.ac.uk
Uddin
Shaikh J
SJ
Shilpi
Jamil A
JA
Rouf
Razina
R
Ferdous
Monzur-E-Mohsina
ME
Nahar
Lutfun
L
D000818:Animals; D002490:Central Nervous System / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006993:Hypnotics and Sedatives / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D029582:Meliaceae; D051379:Mice; D010424:Pentobarbital; D008517:Phytotherapy; D024301:Plant Bark; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018514:Plant Structures; D011597:Psychomotor Performance / Q000187:drug effects; D012890:Sleep / Q000187:drug effects*
D006993:Hypnotics and Sedatives; D010936:Plant Extracts; D010424:Pentobarbital