title: Multislice CT in emergency room management of patients with chest pain and medium-low probability of acute coronary syndrome.
abstract: OBJECTIVE
  The main cause of acute chest pain, which accounts for 6.5% of urgent medical examinations in emergency rooms in Italy, is acute coronary syndrome (ACS). We performed this prospective study to evaluate the diagnostic accuracy of a 16-channel computed tomography (CT) scanner with dedicated software in a group of patients with chest pain and medium to low risk of ACS.
  
  
  METHODS
  This study involved a selected group of 31 patients reporting chest pain with a medium to low probability of ACS, defined on the basis of preliminary tests [electrocardiogram (ECG) and serum cardiac markers]. Coronary angiography, performed within 24 h of MSCT, was used as the gold standard.
  
  
  RESULTS
  MSCT identified the presence of occlusions and significant (>50%) or nonsignificant stenoses in the main coronary segments, with a sensitivity of 65%, a specificity of 98.8%, a positive predictive value (PPV) of 81.2%, a negative predictive value (NPV) of 97.3% and an accuracy of 96.4%. Significant stenoses and occlusions were detected with a sensitivity of 71.4%, a specificity of 99.6%, a PPV of 93.7%, an NPV of 97.7% and an accuracy of 97.5%.
  
  
  CONCLUSIONS
  Due to its high NPV, this technique can rule out significant stenoses or coronary occlusions provided that image quality is excellent. In patients with a medium to low coronary risk, MSCT is a more accurate indicator of the need for coronary angiography than is exercise stress testing, which is less expensive but has lower predictive values.
authors.affiliation: UO di Radiologia, Istituti Ospitalieri di Cremona, Viale Concordia 1, 26100, Cremona, Italy. lucioolivetti@libero.it
authors.forename: L
authors.initials: L
authors.lastname: Olivetti
authors.forename: G
authors.initials: G
authors.lastname: Mazza
authors.forename: D
authors.initials: D
authors.lastname: Volpi
authors.forename: F
authors.initials: F
authors.lastname: Costa
authors.forename: O
authors.initials: O
authors.lastname: Ferrari
authors.forename: S
authors.initials: S
authors.lastname: Pirelli
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D002637:Chest Pain / Q000000981:diagnostic imaging*; D017023:Coronary Angiography; D023921:Coronary Stenosis / Q000000981:diagnostic imaging*; D004562:Electrocardiography; D004632:Emergency Medical Services; D005080:Exercise Test; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000000981:diagnostic imaging; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012307:Risk Factors; D012680:Sensitivity and Specificity; D036542:Tomography, Spiral Computed