Cross-talk between the endocytic pathway and the endoplasmic reticulum in cross-presentation by MHC class I molecules.
Cross-presentation of exogenous proteins on MHC class I complexes contributes to the priming CD8(+) T-cell responses. However, the mechanisms by which antigen-presenting cells transfer internalized proteins to the MHC class I loading pathway are not well understood. Endocytosed proteins often appear to require proteasomal processing and transport into the endoplasmic reticulum, but the intracellular routes involved in cross-presentation remain unclear. Understanding the molecular and cellular basis of cross-presentation will illuminate novel aspects of cell physiology and might lead to improved vaccine design.
Monu
Ngozi
N
Cancer Institute, New York University School of Medicine, 522 First Avenue, New York, NY 10016, USA.
Trombetta
E Sergio
ES
D000818:Animals; D045142:Cross-Priming / Q000276:immunology*; D004705:Endocytosis / Q000276:immunology*; D004721:Endoplasmic Reticulum / Q000276:immunology* / Q000378:metabolism; D015395:Histocompatibility Antigens Class I / Q000276:immunology* / Q000378:metabolism*; D006801:Humans; D015398:Signal Transduction / Q000276:immunology*
D015395:Histocompatibility Antigens Class I