Comparison of the effects of taurine with those of related sulfur-containing compounds on pyridoxal-induced adrenomedullary catecholamine release and glycogenolysis in the rat.
Taurine (2-aminoethanesulfonic acid) is known to attenuate the release of adrenomedullary catecholamines and ensuing hepatic glycogenolysis and hyperglycemia induced by pyridoxal in the rat. Using this animal model, the present study was undertaken to assess the impact that simple structural modifications of the taurine molecule might have on its antagonistic actions against PL. Removal of the amino group (ethanesulfonic acid) or shortening the carbon chain by one methylene (2-aminomethanesulfonic acid) raised the protective actions of taurine. While N-alkylation (N-methyltaurine) or replacement of the amino group by hydroxyl (isethionic acid) had a lowering effect, substituting a sulfhydryl group (2-mercaptoethanesulfonic acid) for the 2-amino group abolished all antagonistic properties associated with taurine. The sulfinic acid analog (hypotaurine) was equipotent with taurine, but the carboxylate isostere (beta-alanine) was inactive. Propranolol, a nonspecific beta-adrenoceptor antagonist, enhanced the antiglycogenolytic effect of taurine and of all structurally related compounds capable of attenuating the outflow of adrenal catecholamines elicited by pyridoxal.
Lau-Cam
Cesar A
CA
Department of Pharmaceutical Science, St. John's University, College of Pharmacy and Allied Health Professions, Jamaica, NY 11439, USA. claucam@usa.net
Patel
Jagir P
JP
D000313:Adrenal Medulla / Q000187:drug effects* / Q000378:metabolism; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002395:Catecholamines / Q000097:blood*; D006003:Glycogen / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D008297:Male; D011730:Pyridoxal / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013457:Sulfur Compounds / Q000378:metabolism*; D013654:Taurine / Q000737:chemistry / Q000378:metabolism*; D014803:Vitamin B Complex / Q000494:pharmacology*
D001786:Blood Glucose; D002395:Catecholamines; D013457:Sulfur Compounds; D014803:Vitamin B Complex; D013654:Taurine; D011730:Pyridoxal; D006003:Glycogen