Catalytic enantioselective Diels-Alder reaction in ionic liquid via a recyclable chiral In(III) complex.
[Structure: see text] A recyclable, air- and moisture-stable chiral indium complex in [hmim][PF6-] ionic liquid has been developed. The cycloaddition of a variety of cyclic and open-chained dienes to 2-methacrolein and 2-bromoacrolein resulted in good yields and excellent enantioselectivities (up to 98% ee). Moreover, the chiral In(III) complex can be reused for seven successive cycles with comparable enantioselectivities and yields without loss of catalytic activity.
Fu
Fan
F
School of Physical & Mathematical Sciences, Division of Chemistry and Biological Chemistry, Nanyang Technological University, 1 Nanyang Walk, Blk 5, Level 3, Singapore 637616.
Teo
Yong-Chua
YC
Loh
Teck-Peng
TP