Posterior cingulate neurometabolite profiles and clinical phenotype in frontotemporal dementia.
Proton magnetic resonance spectroscopy was used to compare metabolite levels from a posterior cingulate voxel in a group of patients with 2 syndromic subtypes of frontotemporal dementia (n=10) and an age and education-matched group with Alzheimer disease (n=10). Overall, frontotemporal dementia was indistinguishable from Alzheimer disease, though differences in N-acetylaspartate emerged between patients with the SD and progressive nonfluent aphasia subtypes, attributable to 2 atypical results among the latter. Such values may index cases with atrophy in posterior cortical regions presenting with progressive nonfluent aphasia.
Garrard
Peter
P
Institute of Cognitive Neuroscience, University College London, and Department of Clinical Neurosciences, Royal Free Hospital, Pond Street, Hampstead, London, UK. p.garrard@ucl.ac.uk
Schott
Jonathan M
JM
MacManus
David G
DG
Hodges
John R
JR
Fox
Nicholas C
NC
Waldman
Adam D
AD
D000368:Aged; D000544:Alzheimer Disease / Q000378:metabolism / Q000473:pathology*; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000378:metabolism; D001284:Atrophy / Q000175:diagnosis / Q000378:metabolism; D003704:Dementia / Q000145:classification / Q000378:metabolism / Q000473:pathology*; D003937:Diagnosis, Differential; D005260:Female; D005625:Frontal Lobe / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D007294:Inositol / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D016555:Matched-Pair Analysis; D008875:Middle Aged; D013702:Temporal Lobe / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology
D001224:Aspartic Acid; D007294:Inositol; C000179:N-acetylaspartate