title: Three-dimensional structure of S-adenosyl-L-homocysteine hydrolase from Plasmodium falciparum.
abstract: Structural information of Plasmodium falciparum S-adenosyl-L-homocysteine hydrolase (PfSAHH) has been expected to provide new-type chemotherapeutic agents against malaria. Here we report the crystal structure of PfSAHH. The present structure should provide opportunities to design potent and selective PfSAHH inhibitors.
authors.affiliation: School of Pharmaceutical Sciences, Showa University, Tokyo 142-8555, Japan.
authors.forename: Nobutada
authors.initials: N
authors.lastname: Tanaka
authors.forename: Masayuki
authors.initials: M
authors.lastname: Nakanishi
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Kusakabe
authors.forename: Katsura
authors.initials: K
authors.lastname: Shiraiwa
authors.forename: Saori
authors.initials: S
authors.lastname: Yabe
authors.forename: Yasutomo
authors.initials: Y
authors.lastname: Ito
authors.forename: Yukio
authors.initials: Y
authors.lastname: Kitade
authors.forename: Kazuo T
authors.initials: KT
authors.lastname: Nakamura
mesh_terms: D043383:Adenosylhomocysteinase / Q000737:chemistry*; D000818:Animals; D003460:Crystallization; D018360:Crystallography, X-Ray; D010963:Plasmodium falciparum / Q000201:enzymology*
chemical_list: D043383:Adenosylhomocysteinase