title: Cyclopentanone ring-cleaved pleuromutilin derivatives.
abstract: Ring-cleaved pleuromutilin derivatives comprised of a [5.3.1] bicyclic core structure have been synthesized and evaluated in vitro as antibacterial agents. Four of the compounds described were found to have MICs<or=4 microg/mL against marker strains of Streptococcus pneumoniae and Staphylococcus aureus.
authors.affiliation: Anti-infective Chemistry, Bristol-Myers Squibb Pharmaceutical Research Institute, 5 Research Parkway, P.O. Box 5100, Wallingford, CT 06492, USA. springd@wyeth.com <springd@wyeth.com>
authors.forename: Dane M
authors.initials: DM
authors.lastname: Springer
authors.forename: Amy
authors.initials: A
authors.lastname: Bunker
authors.forename: Bing-Yu
authors.initials: BY
authors.lastname: Luh
authors.forename: Margaret E
authors.initials: ME
authors.lastname: Sorenson
authors.forename: Jason T
authors.initials: JT
authors.lastname: Goodrich
authors.forename: Joanne J
authors.initials: JJ
authors.lastname: Bronson
authors.forename: Kenneth
authors.initials: K
authors.lastname: DenBleyker
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Dougherty
authors.forename: Joan
authors.initials: J
authors.lastname: Fung-Tomc
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D004224:Diterpenes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D011083:Polycyclic Compounds; D013211:Staphylococcus aureus / Q000187:drug effects; D013296:Streptococcus pneumoniae / Q000187:drug effects; D013329:Structure-Activity Relationship; D000097567:Pleuromutilins
chemical_list: D000900:Anti-Bacterial Agents; D004224:Diterpenes; D011083:Polycyclic Compounds; D000097567:Pleuromutilins