title: Investigating biological activity spectrum for novel quinoline analogues.
abstract: The lack of the wide spectrum of biological data is an important obstacle preventing the efficient molecular design. Quinoline derivatives are known to exhibit a variety of biological effects. In the current publication, we tested a series of novel quinoline analogues for their photosynthesis-inhibiting activity (the inhibition of photosynthetic electron transport in spinach chloroplasts (Spinacia oleracea L.) and the reduction of chlorophyll content in Chlorella vulgaris Beij.). Moreover, antiproliferative activity was measured using SK-N-MC neuroepithelioma cell line. We described the structure-activity relationships (SAR) between the chemical structure and biological effects of the synthesized compounds. We also measured the lipophilicity of the novel compounds by means of the RP-HPLC and illustrate the relationships between the RP-HPLC retention parameter logK (the logarithm of capacity factor K) and logP data calculated by available programs.
authors.affiliation: Institute of Chemistry, University of Silesia, Szkolna 9, 40007 Katowice, Poland.
authors.forename: Robert
authors.initials: R
authors.lastname: Musiol
authors.forename: Josef
authors.initials: J
authors.lastname: Jampilek
authors.forename: Katarina
authors.initials: K
authors.lastname: Kralova
authors.forename: Des R
authors.initials: DR
authors.lastname: Richardson
authors.forename: Danuta
authors.initials: D
authors.lastname: Kalinowski
authors.forename: Barbara
authors.initials: B
authors.lastname: Podeszwa
authors.forename: Jacek
authors.initials: J
authors.lastname: Finster
authors.forename: Halina
authors.initials: H
authors.lastname: Niedbala
authors.forename: Anna
authors.initials: A
authors.lastname: Palka
authors.forename: Jaroslaw
authors.initials: J
authors.lastname: Polanski
mesh_terms: D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects; D048408:Chlorella vulgaris / Q000187:drug effects*; D002734:Chlorophyll; D002736:Chloroplasts / Q000187:drug effects*; D002851:Chromatography, High Pressure Liquid; D004579:Electron Transport / Q000187:drug effects; D006801:Humans; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D018241:Neuroectodermal Tumors, Primitive, Peripheral / Q000188:drug therapy; D010788:Photosynthesis / Q000187:drug effects; D011804:Quinolines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D018724:Spinacia oleracea / Q000187:drug effects*; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
chemical_list: D000935:Antifungal Agents; D000970:Antineoplastic Agents; D011804:Quinolines; D002734:Chlorophyll