[Effect of leptin in the treatment of obesity and influences of diet in the secretion and action of hormone].
The obesity is a multicausal disease that includes exogenous and endogenous factors. We emphasized the leptin, a hormone produced by adipose tissue, whose receiver is in the hypothalamus. The leptin has been considered important in the development of the obesity, because it influences in the energy intake and expenditure. In the revision one sets out to evaluate the leptin like factor related to the development of the obesity, as well as the influence of diet in the secretion and action of leptin. In the human obesity, the deficiency of functional leptin is rare, nevertheless, can exist leptin resistance. After the loss weight it happens reduction in the leptin levels, which can be in the recovery of body weight. The leptin is regulated by food intake and their circulating levels and potential of action are associated with content of macronutrients of the diet and the body composition individually. Nevertheless, studies demonstrated the high and the low food intake can influence in the leptin secretion, independent of the effect on adiposity. In addition, the fat of diet presents important effect in secretion and action of leptin. Also the zinc deficiency has been associated with the reduced levels of leptin. Several experimental studies have been made to evaluate the effect of the administration of leptin in treatment of obesity, by means of injections, inhalation or more active forms of leptin. Nevertheless, we need similar studies with humans. Is important the development of studies that associate the environmental factors, particularly the diet, with regulation of serum levels and action of leptin in humans.
Rosado
E L
EL
Departamento de Nutrição e Dietética, Instituto de Nutrição Josué de Castro, Universidade Federal do Rio de Janeiro-RJ, Brasil. elianerosado@nutricao.ufrj.br
Monteiro
J B
JB
Chaia
V
V
do Lago
M F
MF
D001835:Body Weight / Q000502:physiology; D002986:Clinical Trials as Topic; D004032:Diet; D006801:Humans; D020738:Leptin / Q000378:metabolism* / Q000494:pharmacology / Q000627:therapeutic use; D009765:Obesity / Q000188:drug therapy*
D020738:Leptin