title: Subcutaneous panniculitis-like T-cell lymphoma in a 26-month-old child with a review of the literature.
abstract: Subcutaneous panniculitis-like T-cell lymphoma is a rare cytotoxic T-cell lymphoma of the skin that preferentially infiltrates the subcutaneous tissue. We report here this lymphoma occurring in a 26-month-old Korean girl. She presented with multiple erythematous subcutaneous nodules on both extremities and her back along with systemic symptoms. She had a protracted course of multiple erythematous subcutaneous nodules for 1 month and a spiking fever was often noted. The histopathologic findings for the subcutaneous nodules were lobular panniculitis-like material that was composed of atypical lymphocytes and histiocytes. The atypical lymphocytes characteristically rimmed individual fat cells in a lace-like pattern and some of the histiocytes showed phagocytosed white blood cells occasionally. Immunophenotypic studies showed CD3(+), CD45RO(+), CD20(-), CD4(-), CD8(+), and CD56(-). She is currently being treated with combination chemotherapy of cyclophosphamide, doxorubicin, vincristine, and prednisolone.
authors.affiliation: Department of Dermatology, Kangnam St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
authors.forename: Jun Hee
authors.initials: JH
authors.lastname: Yim
authors.forename: Mi-Yeon
authors.initials: MY
authors.lastname: Kim
authors.forename: Hyung Ok
authors.initials: HO
authors.lastname: Kim
authors.forename: Bin
authors.initials: B
authors.lastname: Cho
authors.forename: Nak-Gyun
authors.initials: NG
authors.lastname: Chung
authors.forename: Young Min
authors.initials: YM
authors.lastname: Park
mesh_terms: D002675:Child, Preschool; D005260:Female; D006801:Humans; D016399:Lymphoma, T-Cell / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D015434:Panniculitis / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D040521:Subcutaneous Tissue / Q000473:pathology*