title: A case of mixed connective tissue disease presenting with nephrotic syndrome.
abstract: A 70-year-old woman was admitted to our hospital for the treatment of diffuse scleroderma and marked edema in the lower extremities. Renal biopsy revealed membranous change, interstitial nephritis, and intimal hyperplasia of the small arteries. The patient was diagnosed as having mixed connective tissue disease (MCTD) presenting with nephrotic syndrome (NS). She responded well to a combination treatment consisting of methylprednisolone (m-PSL) pulse therapy, oral PSL, and cyclosporine A (CsA). We speculated on the actual pathogenesis of NS in this case of MCTD.
authors.affiliation: Department of Internal Medicine, Chugoku Central Hospital of the Mutual Aid Association of Public School Teachers, 6-3-1 Nishifukatsu-cho, Fukuyama 721-8581, Japan. h-kuroda@fukuyama.hiroshima.med.or.jp
authors.forename: Hiro
authors.initials: H
authors.lastname: Kuroda
authors.forename: Keita
authors.initials: K
authors.lastname: Ishii
authors.forename: Yuji
authors.initials: Y
authors.lastname: Negoro
authors.forename: Hiroko
authors.initials: H
authors.lastname: Sugiyama
authors.forename: Junko
authors.initials: J
authors.lastname: Inoue
authors.forename: Chiga
authors.initials: C
authors.lastname: Ogurusu
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kikuchi
authors.forename: Keisei
authors.initials: K
authors.lastname: Shimoe
authors.forename: Katsutoshi
authors.initials: K
authors.lastname: Sunami