title: 99mTc(CO)3-VIP analogues: preparation and evaluation as tumor imaging agent.
abstract: Vasoactive intestinal peptide (VIP) receptors are expressed abundantly on many types of tumors and, hence, radiolabeled VIP analogues are being explored for tumor imaging and therapy. Here, we report synthesis of three VIP analogues and their radiolabeling with (99m)Tc via a novel tricarbonyl synthon. The radiolabeled product could be prepared in high yields (>95%) and stability. In vitro studies showed significant uptake of (99m)Tc(CO)((3))-VP05 in human colon carcinoma cells. Biodistribution studies in animal tumor model showed 0.4-1%ID/g tumor uptake.
authors.affiliation: Radiopharmaceuticals Division, Bhabha Atomic Research Centre, Mumbai 400085, India.
authors.forename: Kanchan
authors.initials: K
authors.lastname: Kothari
authors.forename: Sudhanand
authors.initials: S
authors.lastname: Prasad
authors.forename: Aruna
authors.initials: A
authors.lastname: Korde
authors.forename: Archana
authors.initials: A
authors.lastname: Mukherjee
authors.forename: Archana
authors.initials: A
authors.lastname: Mathur
authors.forename: Manu
authors.initials: M
authors.lastname: Jaggi
authors.forename: Meera
authors.initials: M
authors.lastname: Venkatesh
authors.forename: Ambikalmajan M R
authors.initials: AM
authors.lastname: Pillai
authors.forename: Rama
authors.initials: R
authors.lastname: Mukherjee
authors.forename: Natesan
authors.initials: N
authors.lastname: Ramamoorthy
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D003110:Colonic Neoplasms / Q000000981:diagnostic imaging*; D006801:Humans; D007553:Isotope Labeling; D051379:Mice; D015609:Organotechnetium Compounds / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D011877:Radionuclide Imaging; D014660:Vasoactive Intestinal Peptide / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000493:pharmacokinetics
chemical_list: D015609:Organotechnetium Compounds; C519829:techentium 99m tricarbonyl VD5 peptide; C519828:technetium 99m tricarbonyl VD4 peptide; C519827:technetium 99m tricarbonyl VP05 peptide; D014660:Vasoactive Intestinal Peptide