title: Propylthiouracil-related hemorrhagic diathesis: a case report and review of the literature.
abstract: We present an unusual case of a drug-related hemorrhagic diathesis. One month prior to admission, the patient was diagnosed at another medical center as having Graves' disease and propylthiouracil therapy (PTU) was initiated. Since clinical recovery was not achieved, the PTU was quickly increased to an unconventional daily dose of 1,000 mg. The patient was referred to our hospital because of spontaneous epistaxis, multiple ecchymoses and prolonged prothrombin time (PT) and activated partial thromboplastin time (aPTT), which developed soon after the increase in PTU dose. Drug-related hemorrhagic diathesis was considered, after other possible causes had been eliminated. To the best of our knowledge, this is the first reported case of spontaneous hemorrhage due to PTU use.
authors.affiliation: Department of Internal Medicine, Gaziantep University, Gaziantep TR-27310, Turkey.
authors.forename: Ersin
authors.initials: E
authors.lastname: Akarsu
authors.forename: Hakan
authors.initials: H
authors.lastname: Buyukhatipoglu
authors.forename: Sebnem
authors.initials: S
authors.lastname: Aktaran
authors.forename: Ramazan
authors.initials: R
authors.lastname: Geyik
mesh_terms: D000328:Adult; D013956:Antithyroid Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006111:Graves Disease / Q000188:drug therapy; D006474:Hemorrhagic Disorders / Q000097:blood / Q000139:chemically induced*; D006801:Humans; D010314:Partial Thromboplastin Time; D011441:Propylthiouracil / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D011517:Prothrombin Time
chemical_list: D013956:Antithyroid Agents; D011441:Propylthiouracil