Lignans from Arctium lappa and their inhibition of LPS-induced nitric oxide production.
A new butyrolactone sesquilignan, isolappaol C (1), together with four known lignans, lappaol C (2), lappaol D (3), lappaol F (4), and diarctigenin (5), were isolated from the methanolic extract of the seeds from the Arctium lappa plant. The structure of isolappaol C (1) was determined by spectral analysis including 1D- and 2D-NMR. All the isolates were evaluated for their inhibitory effects on the LPS-induced nitric oxide production using murine macrophage RAW264.7 cells. Lappaol F (4) and diarctigenin (5) strongly inhibited NO production in the LPS-stimulated RAW264.7 cells with IC(50) values of 9.5 and 9.6 microM, respectively.
Park
So Young
SY
College of Pharmacy, Chungbuk National University, Cheongju 361-763, Korea.
Hong
Seong Su
SS
Han
Xiang Hua
XH
Hwang
Ji Sang
JS
Lee
Dongho
D
Ro
Jai Seup
JS
Hwang
Bang Yeon
BY
D000818:Animals; D031170:Arctium / Q000737:chemistry*; D002460:Cell Line; D017705:Lignans / Q000494:pharmacology*; D008070:Lipopolysaccharides / Q000494:pharmacology*; D051379:Mice; D009569:Nitric Oxide / Q000096:biosynthesis*; D013057:Spectrum Analysis / Q000379:methods
D017705:Lignans; D008070:Lipopolysaccharides; D009569:Nitric Oxide; C532887:diarctigenin