title: Dopamine/serotonin receptor ligands. Part 15: Oxygenation of the benz-indolo-azecine LE 300 leads to novel subnanomolar dopamine D1/D5 antagonists.
abstract: Relying on the high affinities of the benz-indolo-azecine LE 300 (1) and the hydroxylated dibenz-azecine LE 404 (2b) for the D1/D5 receptor subtypes, we synthesized methoxylated, hydroxylated and an indole-N methylated derivatives of 1 (Fig. 1). Hydroxylation of azecine derivatives is beneficial with regard to the affinities and selectivities for all the dopamine receptor subtypes. The 'serotonin-derived' 3-oxygenated target compounds but not the 11-oxygenated analogues were superior to the unsubstituted LE 300. 11-Methoxy-7,14-dimethyl-6,7,8,9,14,15-hexahydro-5H-indolo[3,2-f][3]benzazecine (3e) was found to be the most potent antagonist at D2/D3/D4 and D5 receptor subtypes (Ki for D5 = 0.23 nmol) of all known benz-indolo-azecines.
authors.affiliation: Institut für Pharmazie, Lehrstuhl für Pharmazeutische/Medizinische Chemie, Friedrich-Schiller-Universität Jena, Philosophenweg 14, D-07743 Jena, Germany.
authors.forename: Christoph
authors.initials: C
authors.lastname: Enzensperger
authors.forename: Susann
authors.initials: S
authors.lastname: Kilian
authors.forename: Marit
authors.initials: M
authors.lastname: Ackermann
authors.forename: Anne
authors.initials: A
authors.lastname: Koch
authors.forename: Kristin
authors.initials: K
authors.lastname: Kelch
authors.forename: Jochen
authors.initials: J
authors.lastname: Lehmann
mesh_terms: D018492:Dopamine Antagonists / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D007211:Indoles / Q000737:chemistry* / Q000494:pharmacology; D008024:Ligands; D010100:Oxygen / Q000737:chemistry; D011954:Receptors, Dopamine / Q000187:drug effects*; D013329:Structure-Activity Relationship
chemical_list: C409874:7-methyl-6,7,8,9,14,15-hexahydro-5H-benz(d)indolo(2,3-g)azecine; D018492:Dopamine Antagonists; D007211:Indoles; D008024:Ligands; D011954:Receptors, Dopamine; D010100:Oxygen