title: Sodium hyaluronate eye drops prevent late-onset bleb leakage after trabeculectomy with mitomycin C.
abstract: OBJECTIVE
  To evaluate the efficacy of sodium hyaluronate eye drops for prevention of late-onset bleb leakage after trabeculectomy with mitomycin C (MMC).
  
  
  METHODS
  Sixty-eight patients (68 eyes) who had trabeculectomy with MMC from March 1995 to February 2002 at the Marui Eye Clinic or the Department of Ophthalmology, Fukushima Medical University Hospital were examined in this study. Twenty-two were treated postoperatively with sodium hyaluronate eye drops (sodium hyaluronate group) and 46 eyes were not treated postoperatively (control group). The blebs were classified according to the avascular area, epithelial defect and degree of bleb wall leakage. Both groups were assigned classes (0, avascular or partial avascular bleb; 1, avascular or partial avascular bleb with an epithelial defect; 2, avascular or partial avascular bleb with oozing; 3, avascular or partial avascular bleb with a point of leakage).
  
  
  RESULTS
  Follow-up duration ranged from 10 to 116 months (mean+/-SD, 57.6+/-30.5). The incidence of reclassification from class 1 to class 0 was significantly greater in the sodium hyaluronate group (four of six class 1 eyes improved to class 0 after application of sodium hyaluronate eye drops) than in the control group (zero of 10 eyes) (P=0.008). And, the incidence of reclassification from class 1 to class 2 or class 3 was significantly smaller in the sodium hyaluronate group (one of six eyes) than in the control group (nine of 10 eyes) (P=0.008).
  
  
  CONCLUSIONS
  Sodium hyaluronate eye drops may prevent late-onset bleb leakage after trabeculectomy with MMC.
authors.affiliation: The Marui Eye Clinic, Minamisouma, Fukushima, Minamisouma, Japan. hide1234@ruby.ocn.ne.jp
authors.forename: H
authors.initials: H
authors.lastname: Sagara
authors.forename: T
authors.initials: T
authors.lastname: Iida
authors.forename: K
authors.initials: K
authors.lastname: Suzuki
authors.forename: T
authors.initials: T
authors.lastname: Fujiwara
authors.forename: H
authors.initials: H
authors.lastname: Koizumi
authors.forename: K
authors.initials: K
authors.lastname: Yago
mesh_terms: D000328:Adult; D000368:Aged; D001082:Aqueous Humor / Q000378:metabolism*; D001768:Blister / Q000150:complications; D019573:Epithelium, Corneal / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006820:Hyaluronic Acid / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000009:adverse effects*; D019384:Nucleic Acid Synthesis Inhibitors / Q000009:adverse effects*; D009883:Ophthalmic Solutions; D011182:Postoperative Care / Q000379:methods; D013666:Tears / Q000502:physiology; D014130:Trabeculectomy / Q000009:adverse effects* / Q000379:methods; D016896:Treatment Outcome
chemical_list: D019384:Nucleic Acid Synthesis Inhibitors; D009883:Ophthalmic Solutions; D016685:Mitomycin; D006820:Hyaluronic Acid