title: [18F]Fluorodeoxyglucose as a memory marker of transient myocardial ischaemia.
abstract: BACKGROUND
  Experimental data have shown that glucose utilization increases during acute myocardial ischaemia, and may persist for up to 24 h. Whether fluorodeoxyglucose (FDG) uptake can be imaged as a memory marker of ischaemia in humans is unknown.
  
  
  METHODS
  Patients with mild-to-moderate ischaemia on exercise single photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) underwent repeat exercise testing within 1-2 weeks. Positron emission tomography (PET) was performed after injection of FDG 60 min post-exercise. SPECT and PET images were assessed visually, aided by circumferential profile-based analysis modified for 'hot-spot' imaging.
  
  
  RESULTS
  Twelve men with stress SPECT ischaemia (mean age, 69 years; nine with known coronary artery disease) were studied. The mean rate-pressure products for the first (SPECT) and second (FDG PET) exercise tests were similar (22,841+/-7321 vs. 22,680+/-7393 mmHg x bpm, P=NS). Overall, six of 12 patients studied had evidence of FDG uptake. The extent of ischaemia on SPECT was similar in FDG positive and FDG negative patients (summed difference score 10.6+/-6.9 vs. 8.0+/-1.6, P=NS). All patients with a positive FDG scan had uptake in either an ischaemic SPECT region or in a territory with known CAD by angiography.
  
  
  CONCLUSIONS
  Regional myocardial uptake of FDG is enhanced even when injected 1 h post-exercise stress in a subset of patients with ischaemia on exercise SPECT MPI. The ability to image FDG uptake injected 1 h after an ischaemic episode suggests the potential utility of FDG as a memory marker of transient ischaemia.
authors.affiliation: Division of Cardiology, Brown Medical School, Rhode Island Cardiology Center, Providence, Rhode Island, USA.
authors.forename: Brian G
authors.initials: BG
authors.lastname: Abbott
authors.forename: Yi-Hwa
authors.initials: YH
authors.lastname: Liu
authors.forename: James A
authors.initials: JA
authors.lastname: Arrighi
mesh_terms: D000368:Aged; D000792:Angiography / Q000379:methods; D019788:Fluorodeoxyglucose F18 / Q000493:pharmacokinetics*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D017202:Myocardial Ischemia / Q000188:drug therapy*; D009206:Myocardium / Q000473:pathology; D010477:Perfusion; D049268:Positron-Emission Tomography / Q000379:methods*; D011312:Pressure; D015203:Reproducibility of Results; D013997:Time Factors; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*
chemical_list: D019788:Fluorodeoxyglucose F18