First chiral phosphoroamidite-phosphite ligands for highly enantioselective and versatile Pd-catalyzed asymmetric allylic substitution reactions.
[reaction: see text] A series of phosphite-phosphoroamidite ligands, derived from readily available d-xylose, has been successfully applied for the first time in the Pd-catalyzed allylic substitution of several substrates with different steric and electronic properties, with high enantioselectivities (ee's up to 98) and activities in standard conditions.
Raluy
Eva
E
Departament de Química Física i Inorgànica, Universitat Rovira i Virgili, C/ Marcelli Domingo, s/n 43007 Tarragona, Spain.
Claver
Carmen
C
Pàmies
Oscar
O
Diéguez
Montserrat
M