SFK-STAT pathway: an alternative and important way to malignancies.
Signal transducers and activators of transcription (STAT) proteins play a crucial role in mediating signals from a diverse spectrum of cytokine receptors. STAT is thought to be activated by JAK family kinases (JFK) in many cytokine receptor signal pathways; however, recent studies have demonstrated an alternative pathway to activate STAT by Src family kinases (SFK) in growth factor receptor signal. We also observed STAT5 phosphorylation by Lyn, a member of SFK, in our two recent studies. We introduce these studies and review the literature of STAT activation by SFK and aberrant activation of STAT by oncogenic signals.
Hayakawa
Fumihiko
F
Department of Hematology and Oncology, Nagoya University, Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan. bun-hy@med.nagoya-u.ac.jp
Naoe
Tomoki
T
D000818:Animals; D002471:Cell Transformation, Neoplastic; D006801:Humans; D053612:Janus Kinases / Q000235:genetics / Q000502:physiology; D009154:Mutation; D010766:Phosphorylation; D050791:STAT Transcription Factors / Q000235:genetics / Q000502:physiology*; D050799:STAT5 Transcription Factor / Q000235:genetics / Q000502:physiology; D015398:Signal Transduction; D019061:src-Family Kinases / Q000235:genetics / Q000502:physiology*
D050791:STAT Transcription Factors; D050799:STAT5 Transcription Factor; D053612:Janus Kinases; C060902:lyn protein-tyrosine kinase; D019061:src-Family Kinases