A study on medicinal plants from Malaysia focused on Acalypha siamensis Oliv. ex Gage. isolation and structure of a new tetraterpene, acalyphaser A.
As a part of our chemical studies on Malaysian medicinal plants, five Malaysian plant species were evaluated by cytotoxicity assays using P388 murine leukemia cells. Since Acalypha siamensis exhibited the strongest growth inhibition, its constituents were studied as the object of search for bioactive materials. A novel tetraterpene, acalyphaser A (1), was isolated in the course of the purification. Its structure was elucidated on the basis of 1D- and 2D-NMR techniques, and mass spectrometry.
Kambara
Hiroto
H
Faculty of Pharmaceutical Science, Life Science Center and Center for Area Research and Development, Kobe Gakuin University, 518 Arise Ikawadani-cho, Nishi-ku, Kobe 651-2180, Japan.
Yamada
Takeshi
T
Tsujioka
Makiko
M
Matsunaga
Shunyo
S
Tanaka
Reiko
R
Ali
Hamed I
HI
Wiart
Christophe
C
Yusof
Mohd
M
Hassan
Hamina
H
Hanifah
Abu
A
Fauzi
Zeesharina Mohd
ZM
Mazlan
Nor Hana
NH
Jay
Michael
M
Kunishima
Munetaka
M
Akaho
Eiichi
E
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival; D002851:Chromatography, High Pressure Liquid; D004354:Drug Screening Assays, Antitumor; D019665:Euphorbiaceae; D007202:Indicators and Reagents / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry / Q000379:methods*; D051379:Mice; D008956:Models, Chemical; D010936:Plant Extracts / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D013729:Terpenes / Q000737:chemistry*; D013778:Tetrazolium Salts / Q000494:pharmacology; D013844:Thiazoles / Q000494:pharmacology
D000970:Antineoplastic Agents; D007202:Indicators and Reagents; D010936:Plant Extracts; D013729:Terpenes; D013778:Tetrazolium Salts; D013844:Thiazoles; C517254:acalyphaser A; C022616:thiazolyl blue