Effect of substituents at the 5-position of the pyridine ring of imidacloprid on insecticidal activity against Periplaneta americana.
The insecticidal activities of imidacloprid derivatives with a wide range of substituents at the 5-position on the pyridine ring against American cockroaches, Periplaneta americana (L.), were measured by injection with and without synergists propyl 2-propynyl phenylphosphonate and piperonyl butoxide. The log(1/MLD) value (MLD = minimal lethal dose in mol) without synergists was 7.96 for the methyl derivative, and the values were lower for other derivatives. Synergists enhanced the potencies of all the compounds tested. Considering these compounds and those with other substituents at this position, the region for maximum activity was predicted to be in the conjunction of the pyridyl 6-chlorine atom with a lipophilic small group in the 5-position.
Kagabu
Shinzo
S
Department of Chemistry, Faculty of Education, Gifu University, Gifu 501-1193, Japan. kagabus@gifu-u.ac.jp
Murase
Yuko
Y
Imai
Rie
R
Ito
Nakako
N
Nishimura
Keiichiro
K
D000818:Animals; D007093:Imidazoles; D007306:Insecticides / Q000138:chemical synthesis*; D015394:Molecular Structure; D000073943:Neonicotinoids; D009574:Nitro Compounds; D010526:Periplaneta
D007093:Imidazoles; D007306:Insecticides; D000073943:Neonicotinoids; D009574:Nitro Compounds; C082359:imidacloprid