The potential of microscopic sterile sponge particles to induce foreign body reaction.
The sterile sponges may lose a significant amount of lint during their routine use in surgery, which is usually neglected. We designed an experimental model to evaluate the potential of sterile sponges to lose lint and to induce foreign body reaction in surgically created wounds. In 15 Wistar rats, separate subcutaneous pockets were created. Left-sided pockets were temporarily packed with sterile sponges, while the right-sided pockets remained empty. All the pockets were then irrigated with sterile saline. The presence of microscopic sponge particles was evaluated in the irrigation materials. After 4 weeks, the presence of inflammation and foreign body reaction were evaluated histologically. Microscopic sponge remnants were present in 14 of 15 samples collected from the left sides. The presence of foreign body giant cells with ingested sponge particles and formation of well-defined foreign body granulomas were observed only in samples collected from the left sides. A statistically significant difference was observed between the two sides when the intensity of inflammation was graded (P= 0.012). Cotton sponges used in surgery are shown to have a potential of losing invisible microscopic particles that have a potential to induce foreign body reaction.
Sari
Alper
A
Department of Plastic and Reconstructive Surgery, Faculty of Medicine, Mersin University, Zeytinlibahce Caddesi, Mersin, Turkey. dralpersari@yahoo.com
Basterzi
Yavuz
Y
Karabacak
Tuba
T
Tasdelen
Bahar
B
Demirkan
Ferit
F
D000818:Animals; D005549:Foreign-Body Reaction / Q000209:etiology* / Q000473:pathology; D010316:Particle Size; D051381:Rats; D017208:Rats, Wistar; D012107:Research Design; D015503:Surgical Sponges / Q000009:adverse effects*