Outcome of surgical treatment for recurrent thymic epithelial tumors with reference to world health organization histologic classification system.
OBJECTIVE
The aim of this study was to clarify the significance of surgical treatment for recurrent thymic epithelial tumors with reference to the World Health Organization (WHO) histological classification system.


METHODS
Among 67 patients with tumor recurrence, 22 underwent a re-resection. There were 1 patient with a type AB tumor, 5 with type B1 tumors, 10 with type B2 tumors, 5 with type B3 tumors, and 1 with a carcinoma.


RESULTS
The 10-year survival rate following the initial resection was 70% in patients who underwent a re-resection and 35% in those who did not. The average intervals from the initial resection to re-resection were 10.3, 7.8, 6.0, 2.4, and 2.6 years for patients with type AB, B1, B2, B3 tumors, and carcinoma, respectively. The patient with a type AB tumor was alive at 2.4 years after re-resection, 12.7 years after the initial resection. The 5-year survival rates following re-resection in the patients with type B1, B2, and B3 tumors were 100, 56, and 60, respectively. The patient with a carcinoma died as a result of the tumor 2 years after re-resection.


CONCLUSIONS
WHO histological classification indicates the outcome of surgical treatment for recurrent thymic epithelial tumors.
Okumura
Meinoshin
M
Department of Surgery (E1), Osaka University Graduate School of Medicine, Osaka, Japan. meinosin@surg1.med.osaka-u.ac.jp
Shiono
Hiroyuki
H
Inoue
Masayoshi
M
Tanaka
Hisaichi
H
Yoon
Hyun-Eng
HE
Nakagawa
Katsuhiro
K
Matsumura
Akihide
A
Ohta
Mitsunori
M
Iuchi
Keiji
K
Matsuda
Hikaru
H
D000328:Adult; D000368:Aged; D006801:Humans; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000601:surgery*; D009367:Neoplasm Staging; D012086:Reoperation; D015996:Survival Rate; D013945:Thymoma / Q000145:classification* / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D013953:Thymus Neoplasms / Q000145:classification* / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D016896:Treatment Outcome; D014944:World Health Organization