Synthesis of encoded modified oligonucleotide libraries. Part 1: orthogonal chemistry.
The basis for further development of combinatorial libraries of modified oligonucleotides tagged by a codifying sequence is discussed. The chemistry involved in the orthogonal synthesis of both strands and some representative examples of building blocks are presented.
Sacca
Paula A
PA
Instituto de Investigaciones en Ingeniería Genética y Biología Molecular, CONICET-UBA, Vuelta de Obligado 2490, Buenos Aires, Argentina.
Fontana
Angelo
A
Montserrat
Javier M
JM
Iribarren
Adolfo M
AM
D002626:Chemistry, Pharmaceutical / Q000379:methods; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D015723:Gene Library; D009841:Oligonucleotides / Q000138:chemical synthesis* / Q000235:genetics
D009841:Oligonucleotides