RNA learns from antisense.
RNA interference provides powerful tools for controlling gene expression in cultured cells. Whether RNAi will provide similarly powerful drugs is unknown. Lessons from development of antisense oligonucleotide drugs may provide some clues.
Corey
David R
DR
Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd., Dallas, Texas 75390-9041, USA. david.corey@utsouthwestern.edu
D000818:Animals; D002626:Chemistry, Pharmaceutical; D015870:Gene Expression / Q000187:drug effects; D006801:Humans; D008954:Models, Biological; D016376:Oligonucleotides, Antisense / Q000737:chemistry* / Q000494:pharmacology; D012313:RNA / Q000737:chemistry* / Q000502:physiology*; D034622:RNA Interference / Q000502:physiology*; D034741:RNA, Small Interfering / Q000737:chemistry* / Q000494:pharmacology / Q000502:physiology*
D016376:Oligonucleotides, Antisense; D034741:RNA, Small Interfering; D012313:RNA