Influence of RGD-containing oligopeptide-coated surface on bone formation in vitro and in vivo.
New bone formation on an RGD-containing oligopeptide-coated surface in vitro and in vivo was investigated. The surface showed two-fold higher osteoblastic cell adhesion and differentiation in vitro, and revealed statistically significant in vivo bone formation compared with the control (P < 0.05).
Kim
Tae-Il
TI
Department of Periodontology, Intellectual Biointerface Engineering Center, Seoul National University, Seoul, South Korea.
Lee
Gene
G
Jang
Jun-Hyeog
JH
Chung
Chong-Pyoung
CP
Ku
Young
Y
D002448:Cell Adhesion / Q000187:drug effects; D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects; D020099:Coated Materials, Biocompatible / Q000008:administration & dosage / Q000737:chemistry; D005353:Fibronectins / Q000008:administration & dosage* / Q000737:chemistry*; D006801:Humans; D009842:Oligopeptides / Q000008:administration & dosage* / Q000737:chemistry*; D010006:Osteoblasts / Q000166:cytology* / Q000187:drug effects / Q000502:physiology*; D010012:Osteogenesis / Q000187:drug effects / Q000502:physiology*
D020099:Coated Materials, Biocompatible; D005353:Fibronectins; D009842:Oligopeptides; C047981:arginyl-glycyl-aspartic acid