title: A novel type of membrane based on cholesteryl phosphocholine, cholesteryl phosphate, or sitosteryl phosphate, and dimyristoylglycerol.
abstract: Mixtures of amphiphilic cholesteryl phosphate (CP), sitosteryl phosphate (SP), or cholesteryl phosphocholine (CPC) with the nonphosphoryl diacyl lipid dimyristoylglycerol (DMG) or with cholesterol give self-organized systems (giant vesicles) in a wide range of pH, as demonstrated by fluorescence microscopy, differential scanning calorimetry, and small-angle X-ray scattering. The water permeability of a 1 : 1 molar mixture of CPC and DMG was also measured by a stopped-flow/light-scattering method. The novel self-organized systems are akin to natural eukaryotic ones, the only difference being the site of the phosphate-containing head-group, located on cholesterol instead of DMG. They might be present in some organisms not yet studied for the composition of their membranes.
authors.affiliation: Centre de Neurochimie, 5, rue Blaise Pascal, F-67084-Strasbourg.
authors.forename: Mari
authors.initials: M
authors.lastname: Gotoh
authors.forename: Nigel
authors.initials: N
authors.lastname: Ribeiro
authors.forename: Bernard
authors.initials: B
authors.lastname: Michels
authors.forename: Mourad
authors.initials: M
authors.lastname: Elhabiri
authors.forename: Anne-Marie
authors.initials: AM
authors.lastname: Albrecht-Gary
authors.forename: Jun
authors.initials: J
authors.lastname: Yamashita
authors.forename: Masakatsu
authors.initials: M
authors.lastname: Hato
authors.forename: Guy
authors.initials: G
authors.lastname: Ourisson
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Nakatani
mesh_terms: D002788:Cholesterol Esters / Q000032:analysis / Q000737:chemistry*; D020404:Glycerophospholipids / Q000032:analysis / Q000737:chemistry*; D008567:Membranes, Artificial; D010767:Phosphorylcholine / Q000032:analysis / Q000737:chemistry*; D012855:Sitosterols / Q000032:analysis / Q000737:chemistry*
chemical_list: D002788:Cholesterol Esters; D020404:Glycerophospholipids; D008567:Membranes, Artificial; D012855:Sitosterols; D010767:Phosphorylcholine; C033095:cholesteryl phosphate; C025473:gamma-sitosterol