title: Expression of a supramolecular complex at a multivalent interface.
abstract: The multivalent binding of a supramolecular complex at a multivalent host surface by combining the orthogonal beta-cyclodextrin (CD) host-guest and metal ion-ethylenediamine coordination motifs is described. As a heterotropic, divalent linker, an adamantyl-functionalized ethylenediamine derivative was used. This was complexed with Cu(II) or Ni(II). The binding of the complexes to a CD self-assembled monolayer (SAM) was studied as a function of pH by means of surface plasmon resonance (SPR) spectroscopy. A heterotropic, multivalent binding model at interfaces was used to quantify the multivalent enhancement at the surface. The Cu(II) complex showed divalent binding to the CD surface with an enhancement factor higher than 100 relative to the formation of the corresponding divalent complex in solution. Similar behavior was observed for the Ni(II) system. Although the Ni(II) system could potentially be trivalent, only divalent binding was observed at the CD SAMs, which was confirmed by desorption experiments.
authors.affiliation: Laboratories for Supramolecular Chemistry & Technology and Molecular Nanofabrication, MESA+ Institute for Nanotechnology, University of Twente, P.O. Box 217, 7500 AE Enschede, The Netherlands.
authors.forename: Olga
authors.initials: O
authors.lastname: Crespo-Biel
authors.forename: Choon Woo
authors.initials: CW
authors.lastname: Lim
authors.forename: Bart Jan
authors.initials: BJ
authors.lastname: Ravoo
authors.forename: David N
authors.initials: DN
authors.lastname: Reinhoudt
authors.forename: Jurriaan
authors.initials: J
authors.lastname: Huskens
mesh_terms: D003300:Copper / Q000737:chemistry*; D005029:Ethylenediamines / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D008024:Ligands; D046911:Macromolecular Substances / Q000737:chemistry; D008958:Models, Molecular; D009532:Nickel / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry*; D012680:Sensitivity and Specificity; D020349:Surface Plasmon Resonance; D013499:Surface Properties; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D005029:Ethylenediamines; D008024:Ligands; D046911:Macromolecular Substances; D009942:Organometallic Compounds; D047392:beta-Cyclodextrins; C031234:ethylenediamine; D003300:Copper; D009532:Nickel; C031215:betadex