Suppression of symptoms of alcohol dependence and craving using high-dose baclofen.
OBJECTIVE
To further test whether the baclofen-induced suppression of motivation to consume alcohol in animals could be transposed to humans.


METHODS
A patient who had neither tolerated nor benefited from other alcohol treatment modalities was put on trial with baclofen on a dosage up to 140 mg/day.


RESULTS
The patient reported dramatic reduction in cravings for and preoccupation with alcohol.


CONCLUSIONS
High-dose baclofen therapy was associated with complete and prolonged suppression of symptoms and consequences of alcohol-dependence.
Bucknam
William
W
wbucknam@hotmail.com
D000427:Alcohol Deterrents / Q000627:therapeutic use*; D000437:Alcoholism / Q000523:psychology / Q000534:rehabilitation*; D001418:Baclofen / Q000627:therapeutic use*; D015928:Cognitive Behavioral Therapy; D018755:GABA Agonists / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009042:Motivation; D012008:Recurrence; D016896:Treatment Outcome
D000427:Alcohol Deterrents; D018755:GABA Agonists; D001418:Baclofen