title: Immune activation and normal levels of endogenous antivirals are seen in healthy adolescents born of HIV-infected mothers.
abstract: Immunological analyses performed in healthy adolescents born of HIV-infected (seroreverters) or healthy mothers (healthy controls; HC) showed that immune activation and a skewing of postthymic differentiation are present in adolescent seroreverters. In-utero HIV exposure results in long-lasting imprinting on the immune system. Alternatively, an immune response naturally more prone to activation could prevent vertical infection. Endogenous antivirals (APOBEC, TRIM5alpha) were comparable in seroreverters and HC, and might not play a role in resistance to vertical HIV infection.
authors.affiliation: Department of Pediatrics, Luigi Sacco Hospital, Milan, Italy.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Vigano
authors.forename: Marina
authors.initials: M
authors.lastname: Saresella
authors.forename: Monica
authors.initials: M
authors.lastname: Schenal
authors.forename: Paola
authors.initials: P
authors.lastname: Erba
authors.forename: Luca
authors.initials: L
authors.lastname: Piacentini
authors.forename: Raffaella
authors.initials: R
authors.lastname: Tornaghi
authors.forename: Valentina
authors.initials: V
authors.lastname: Naddeo
authors.forename: Vania
authors.initials: V
authors.lastname: Giacomet
authors.forename: Manuela
authors.initials: M
authors.lastname: Borelli
authors.forename: Daria
authors.initials: D
authors.lastname: Trabattoni
authors.forename: Mario
authors.initials: M
authors.lastname: Clerici
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D005260:Female; D015658:HIV Infections / Q000276:immunology / Q000635:transmission; D018023:HIV Seronegativity / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular; D018445:Infectious Disease Transmission, Vertical; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious; D011297:Prenatal Exposure Delayed Effects