Impact of rotavirus infections on outpatient clinic visits in chile.
BACKGROUND
Incorporation of new rotavirus vaccines into national programs of developing countries will rely on well-designed cost-effective analysis based on accurate assessment of disease burden. For Chile, rotavirus disease burden is determined mostly by outpatient clinic and emergency room visits and by hospitalizations. We previously estimated a yearly incidence of 8000 and 53,000 hospitalizations and emergency room visits respectively for children <or=3 years of age.


OBJECTIVE
The objective of this study was to quantify the impact of rotavirus as a cause of outpatient clinic visits.


METHODS
A prospective surveillance protocol between the Health Ministry and the University of Chile in 11 outpatient clinics from 6 regions included reporting of all acute diarrhea cases in children <5 years of age and collection of a stool sample for the first 5 children per week.


RESULTS
A total of 5217 acute diarrhea episodes requiring an outpatient medical visit for a total assigned population of 41,927 children <5 years of age were reported from August 1, 2004, to October 30, 2005, in the 11 clinics. A total of 179 rotavirus positive samples were detected from 1313 stools collected for an overall positivity of 13.6% (95% confidence limit: 11.8-15.6%). Rotavirus outpatient visits occurred during all 15 months without a clear seasonal predominance and peaked between 6 months and 2 years of age. G4 types predominated during the 15-month period.


CONCLUSIONS
For Chilean children </=3 years of age, a yearly estimate of 11,658 to 16,305 outpatient medical visits need to be added to previous disease burden estimates.
O'Ryan
Miguel
M
Microbiology and Mycology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile. moryan@med.uchile.cl
Díaz
Janepsy
J
Mamani
Nora
N
Navarrete
Marisol
M
Vallebuono
Clelia
C
D000554:Ambulatory Care Facilities / Q000706:statistics & numerical data*; D002675:Child, Preschool; D002677:Chile / Q000453:epidemiology; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D011159:Population Surveillance / Q000379:methods; D011446:Prospective Studies; D012401:Rotavirus / Q000302:isolation & purification*; D012400:Rotavirus Infections / Q000453:epidemiology*; D012703:Serotyping / Q000379:methods