title: [A recurrent endocrine cell cancer of the stomach showing almost complete remission after chemotherapy for 1 year].
abstract: We report a recurrent case of gastric endocrine cell cancer that showed a remarkable response to systemic chemotherapy. A 70-year-old male who underwent gastroscopy at our hospital showed a 0-IIa-like lesion, but no abnormal CT findings. He was diagnosed with gastric cancer, and underwent a proximal gastrectomy. The resected specimen showed endocrine cell cancer. The tumor was Grimelius-positive histologically and chromogranin A-and NSE-positive immunohistochemically. About 2 years after surgery, liver, lymph node, and bone metastases were detected. Systemic chemotherapy with TS-1 and CDDP was started, and the lesions progressed. Then, by approximately 1 year after CDDP and CPT-11 treatments, the recurrent lesions had diminished remarkably and were no longer seen on CT or FDG-PET.
authors.affiliation: Dept. of Thoracic and Visceral Organ Surgery, Gunma University School of Medicine.
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Sunose
authors.forename: Izumi
authors.initials: I
authors.lastname: Takeyoshi
authors.forename: Susumu
authors.initials: S
authors.lastname: Kawate
authors.forename: Kunihiro
authors.initials: K
authors.lastname: Hamada
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Tsutsumi
authors.forename: Kazuhisa
authors.initials: K
authors.lastname: Arakawa
authors.forename: Nozomi
authors.initials: N
authors.lastname: Tohgo
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Toya
authors.forename: Susumu
authors.initials: S
authors.lastname: Ohwada
authors.forename: Kenji
authors.initials: K
authors.lastname: Kashiwabara
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Morishita
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000473:pathology / Q000556:secondary / Q000601:surgery; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001859:Bone Neoplasms / Q000188:drug therapy* / Q000556:secondary; D002166:Camptothecin / Q000008:administration & dosage / Q000031:analogs & derivatives; D018288:Carcinoma, Small Cell / Q000188:drug therapy* / Q000473:pathology / Q000556:secondary / Q000601:surgery; D002945:Cisplatin / Q000008:administration & dosage; D004334:Drug Administration Schedule; D005743:Gastrectomy; D006801:Humans; D000077146:Irinotecan; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary; D008297:Male; D012074:Remission Induction; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery
chemical_list: D000077146:Irinotecan; D002945:Cisplatin; D002166:Camptothecin