title: Novel cutaneous uses for botulinum toxin type A.
abstract: Botulinum toxin type A is a neurotoxin produced by the bacterium Clostridium botulinum which causes a flaccid muscle paralysis. It has been used extensively in the field of dermatology for the treatment of dynamic rhytides and in the treatment of hyperhidrosis. Botulinum toxin has an excellent safety profile and few side effects when used for these purposes. Recently, botulinum toxin has also been used experimentally in a number of other dermatologic conditions with good results. These conditions include: persistent facial flushing, gustatory sweating and epiphora, anal fissures, familial benign pemphigus (Hailey-Hailey disease), dyshidrotic eczema, and following surgical wound closures. While randomized, controlled prospective trials are still needed to further understand the efficacy and safety of botulinum toxin in these conditions, anecdotal and case report data suggest that botulinum toxin is both safe and efficacious in these and many other procedures.
authors.affiliation: Drexel University College of Medicine, Philadelphia, PA 19144, USA. cb59@drexel.edu
authors.forename: Cheryl
authors.initials: C
authors.lastname: Bansal
authors.forename: Kenny J
authors.initials: KJ
authors.lastname: Omlin
authors.forename: Christine M
authors.initials: CM
authors.lastname: Hayes
authors.forename: Thomas E
authors.initials: TE
authors.lastname: Rohrer
mesh_terms: D000279:Administration, Cutaneous; D019274:Botulinum Toxins, Type A / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D009465:Neuromuscular Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D012871:Skin Diseases / Q000188:drug therapy*; D014945:Wound Healing
chemical_list: D009465:Neuromuscular Agents; D019274:Botulinum Toxins, Type A