title: Local alendronate increases fixation of implants inserted with bone compaction: 12-week canine study.
abstract: Bone compaction has been shown to increase initial implant fixation. Furthermore, bone compaction creates a peri-implant zone of autograft that exerts osteoconductive properties. We have previously shown that locally applied bisphosphonate (alendronate) at 4-week observation can preserve the autograft generated by bone compaction. We now investigate whether the increased amount of autograft, seen at 4 weeks, can increase implant osseointegration and biomechanical fixation. Porous-coated titanium implants were bilaterally inserted with bone compaction into the proximal part of tibia of 10 dogs. On the right side, local bisphosphonate was injected into the bone cavity prior to bone compaction immediately prior to implant insertion. On the left side, saline was used as control. Observation period was 12 weeks. Locally applied bisphosphonate significantly increased biomechanical implant fixation (approximately twofold), bone-to-implant contact (1.2-fold), and peri-implant bone volume fraction (2.3-fold). This study indicates that local alendronate treatment can increase early implant osseointegration and biomechanical fixation of implants inserted by use of bone compaction. Long term effects remain unknown.
authors.affiliation: Orthopaedic Research Laboratory, Department of Orthopaedics, Aarhus University Hospital, Norrebrogade 44, Bldg. 1A, DK-8000 Aarhus C, Denmark. tvj@studmed.au.dk
authors.forename: Thomas
authors.initials: T
authors.lastname: Jakobsen
authors.forename: Søren
authors.initials: S
authors.lastname: Kold
authors.forename: Joan E
authors.initials: JE
authors.lastname: Bechtold
authors.forename: Brian
authors.initials: B
authors.lastname: Elmengaard
authors.forename: Kjeld
authors.initials: K
authors.lastname: Søballe
mesh_terms: D019386:Alendronate / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D001696:Biomechanical Phenomena; D004164:Diphosphonates / Q000008:administration & dosage / Q000494:pharmacology*; D004285:Dogs; D005260:Female; D016268:Internal Fixators; D016348:Osseointegration / Q000187:drug effects* / Q000502:physiology; D019736:Prostheses and Implants; D013977:Tibia / Q000187:drug effects / Q000502:physiology; D014025:Titanium
chemical_list: D004164:Diphosphonates; D014025:Titanium; D019386:Alendronate