Small leucine-rich proteoglycans in the aging skeleton.
Small Leucine-Rich Proteoglyans (SLRPs) are major skeletal extracellular matrix (ECM) components that comprise a family of 13 members containing repeats of a leucine-rich motif. To examine SLRP function, we generated mice deficient in one or more member and analyzed them at the tissue, cell and molecular levels. This review outlines the novel research findings uncovered using these new animal models.
Young
M F
MF
Craniofacial and Skeletal Diseases Branch, NIDCR, NIH, Bethesda, MD 20892, USA. myoung@dir.nidcr.nih.gov
Bi
Y
Y
Ameye
L
L
Xu
T
T
Wadhwa
S
S
Heegaard
A
A
Kilts
T
T
Chen
X D
XD
D000375:Aging / Q000502:physiology*; D020816:Amino Acid Motifs; D000818:Animals; D058578:Biglycan; D001842:Bone and Bones / Q000166:cytology / Q000502:physiology*; D018920:Coculture Techniques; D058575:Decorin; D005109:Extracellular Matrix / Q000502:physiology; D016326:Extracellular Matrix Proteins / Q000235:genetics / Q000502:physiology*; D000071235:Fibromodulin; D051379:Mice; D018345:Mice, Knockout; D023421:Models, Animal; D010006:Osteoblasts / Q000166:cytology / Q000502:physiology; D010010:Osteoclasts / Q000166:cytology / Q000502:physiology; D010012:Osteogenesis / Q000502:physiology; D010805:Physical Conditioning, Animal / Q000502:physiology; D011509:Proteoglycans / Q000235:genetics / Q000502:physiology*
C546885:Bgn protein, mouse; D058578:Biglycan; C546879:Dcn protein, mouse; D058575:Decorin; D016326:Extracellular Matrix Proteins; C000604332:Fmod protein, mouse; D011509:Proteoglycans; D000071235:Fibromodulin