Causes of neuronal heterotopia other than migration disturbances.
A differentiated form of cerebellocortical fragments (case 1) in the white matter or even in the cerebellar dentate nucleus, found in a fetus with trisomy 13, may be due to an auto-transplantation accompanied by a penetrating vessel. A similar condition was observed in the Ammon's horn (case 2) incidentally as a heterotopic tissue fragment of the dentate fascia. Further cause of heterotopia may be speculated as a mechanical separation by a surrounding and developing tissue part in case of organized, differentiated cerebellocortical heterotopia in the white matter (cases 3-5) which were clinically silent. Migration disturbances are not the only cause of neuronal heterotopia since the structure of heterotopia is differentiated and organized by tissue components.
Hori
Akira
A
Research Institute for Longevity Medicine, Fukushimura (Welfare Village) Hospital, Toyohashi, Japan. hori@chojuken.net
D000328:Adult; D000369:Aged, 80 and over; D001808:Blood Vessels / Q000473:pathology; D001927:Brain Diseases / Q000209:etiology* / Q000473:pathology; D002465:Cell Movement; D002531:Cerebellum; D002540:Cerebral Cortex / Q000098:blood supply / Q000473:pathology; D002828:Choristoma / Q000209:etiology* / Q000473:pathology; D005260:Female; D005333:Fetus; D006624:Hippocampus / Q000098:blood supply / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged