Dengue hemorrhagic Fever caused by sequential dengue 1-3 virus infections over a long time interval: Havana epidemic, 2001-2002.
A dengue epidemic caused by dengue virus 3 (DENV-3) occurred in Cuba in 2001-2002. It included cases of dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS). We report neutralizing antibody studies on sera from 54 of 78 DHF/DSS patients that provide evidence of infections occurring in the sequence DENV-1 followed by DENV-3. No sera showed infection in the sequence DENV-2 followed by DENV-3. Some sera showed a pattern of infection in the sequence DENV-1 followed by DENV-2 and then DENV-3. However definitive categorization of a tertiary infection was not possible because of broadly reactive antibodies, which could have been raised by infections in the sequence DENV-1 then DENV-3.
Alvarez
Mayling
M
Department of Virology, Pan American Health Organization/World Health Organization Collaborating Center for the Study of Dengue and Its Vector, Pedro Kourí Tropical Medicine Institute, Havana, Cuba.
Rodriguez-Roche
Rosmari
R
Bernardo
Lídice
L
Vázquez
Susana
S
Morier
Luis
L
Gonzalez
Daniel
D
Castro
Osvaldo
O
Kouri
Gustavo
G
Halstead
Scott B
SB
Guzman
Maria G
MG
D000914:Antibodies, Viral / Q000097:blood; D003462:Cuba / Q000453:epidemiology; D003716:Dengue Virus / Q000145:classification / Q000302:isolation & purification; D006801:Humans; D009500:Neutralization Tests; D019595:Severe Dengue / Q000453:epidemiology*; D013997:Time Factors
D000914:Antibodies, Viral