title: A study on medicinal plants from Malaysia focused on Acalypha siamensis Oliv. ex Gage. isolation and structure of a new tetraterpene, acalyphaser A.
abstract: As a part of our chemical studies on Malaysian medicinal plants, five Malaysian plant species were evaluated by cytotoxicity assays using P388 murine leukemia cells. Since Acalypha siamensis exhibited the strongest growth inhibition, its constituents were studied as the object of search for bioactive materials. A novel tetraterpene, acalyphaser A (1), was isolated in the course of the purification. Its structure was elucidated on the basis of 1D- and 2D-NMR techniques, and mass spectrometry.
authors.affiliation: Faculty of Pharmaceutical Science, Life Science Center and Center for Area Research and Development, Kobe Gakuin University, 518 Arise Ikawadani-cho, Nishi-ku, Kobe 651-2180, Japan.
authors.forename: Hiroto
authors.initials: H
authors.lastname: Kambara
authors.forename: Takeshi
authors.initials: T
authors.lastname: Yamada
authors.forename: Makiko
authors.initials: M
authors.lastname: Tsujioka
authors.forename: Shunyo
authors.initials: S
authors.lastname: Matsunaga
authors.forename: Reiko
authors.initials: R
authors.lastname: Tanaka
authors.forename: Hamed I
authors.initials: HI
authors.lastname: Ali
authors.forename: Christophe
authors.initials: C
authors.lastname: Wiart
authors.forename: Mohd
authors.initials: M
authors.lastname: Yusof
authors.forename: Hamina
authors.initials: H
authors.lastname: Hassan
authors.forename: Abu
authors.initials: A
authors.lastname: Hanifah
authors.forename: Zeesharina Mohd
authors.initials: ZM
authors.lastname: Fauzi
authors.forename: Nor Hana
authors.initials: NH
authors.lastname: Mazlan
authors.forename: Michael
authors.initials: M
authors.lastname: Jay
authors.forename: Munetaka
authors.initials: M
authors.lastname: Kunishima
authors.forename: Eiichi
authors.initials: E
authors.lastname: Akaho
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival; D002851:Chromatography, High Pressure Liquid; D004354:Drug Screening Assays, Antitumor; D019665:Euphorbiaceae; D007202:Indicators and Reagents / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry / Q000379:methods*; D051379:Mice; D008956:Models, Chemical; D010936:Plant Extracts / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D013729:Terpenes / Q000737:chemistry*; D013778:Tetrazolium Salts / Q000494:pharmacology; D013844:Thiazoles / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D007202:Indicators and Reagents; D010936:Plant Extracts; D013729:Terpenes; D013778:Tetrazolium Salts; D013844:Thiazoles; C517254:acalyphaser A; C022616:thiazolyl blue