title: Brewing controversies: Darwinian perspective on the adaptive and maladaptive effects of caffeine and ethanol as dietary autonomic modulators.
abstract: Ethanol and caffeine are two of the oldest human drugs. Their pervasive integration into the modern human diet may reflect behavioral attempts to correct maladaptations induced by evolutionary displacement of the autonomic system. The dietary adoption of caffeine may parallel the emergence of cognition as an independent basis of competition. Enhancement of the cognitive ability to gather and process information likely evolved as a valuable adjunct to physical behavior in prehistoric fight-or-flight encounters. Caffeine effectively exploits this pre-existing association between adrenergic activity and cognitive readiness, leading to its use in the modern environment where success in competition increasingly depends on cognitive, rather than physical, prowess. Ethanol may have emerged as a dietary means to buffer the maladaptive chronic sympathetic activation and fear response associated with stressful lifestyles and the social phobias associated with the dissolution of kin networks. We explore the health implications of ethanol and caffeine use, with particular attention to their acute and chronic effects on the autonomic axis. The putative protective effects of ethanol in surviving major trauma or reducing inflammation and heart disease may relate to tempering the behavioral and cardiovascular consequences of catastrophic or chronic sympathetic activation. Acute or chronic abuse of ethanol manifests paradoxical pro-adrenergic effects such as tremors and insomnia that may partly represent compensatory responses. Compensatory remodeling may also explain why confirmation of detrimental effects related to caffeine-induced sympathetic activation has proven elusive; indeed, paradoxical pro-vagal benefits may eventually be recognized. Ethanol and caffeine are potential agents that may beneficially expand the dynamic range of the autonomic system. In an environment where the Darwinian value of knowledge has increasingly supplanted that of physical traits, the consumption of caffeine and alcohol may represent both a cause and an effect of modern human evolution.
authors.affiliation: Stanford University, Radiology, 470 University Avenue, Palo Alto, CA 94301, United States. ayun@stanford.edu
authors.forename: Anthony J
authors.initials: AJ
authors.lastname: Yun
authors.forename: John D
authors.initials: JD
authors.lastname: Doux
authors.forename: Stephanie M
authors.initials: SM
authors.lastname: Daniel
mesh_terms: D000222:Adaptation, Physiological / Q000187:drug effects / Q000235:genetics; D001341:Autonomic Nervous System / Q000187:drug effects* / Q000503:physiopathology*; D001342:Autonomic Nervous System Diseases / Q000503:physiopathology* / Q000517:prevention & control*; D005075:Biological Evolution; D002110:Caffeine / Q000008:administration & dosage*; D019587:Dietary Supplements; D000431:Ethanol / Q000008:administration & dosage*; D006801:Humans
chemical_list: D002110:Caffeine; D000431:Ethanol