title: New gemacranolides from Eupatorium hualienense.
abstract: Phytochemical investigation of Eupatorium hualienense (C. H. Ou, S. W. Chung, C. I. Peng) has resulted in the isolation of the new sesquiterpene lactones 1-5, named eupahualins A-E, along with the known heliangolide eupasimplicin B (6). The structures of the isolated compounds were established through detailed spectral analyses, especially by means of 2D-NMR techniques. Compounds 1-4 and 6 showed significant activities against cell lines of human chronic myelogenous leukemia (K562) and human bone cancer (U2OS).
authors.affiliation: Institute of Marine Resources, National Sun Yat-sen University, 70 Lien-Hai Road, Kaohsiung, Taiwan 80424, Republic of China.
authors.forename: Ya-Ching
authors.initials: YC
authors.lastname: Shen
authors.forename: Jiun-Yang
authors.initials: JY
authors.lastname: Jang
authors.forename: Ashraf Taha
authors.initials: AT
authors.lastname: Khalil
authors.forename: Lien Chai
authors.initials: LC
authors.lastname: Chiang
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D036602:Eupatorium / Q000737:chemistry*; D006801:Humans; D007783:Lactones / Q000737:chemistry* / Q000494:pharmacology; D015394:Molecular Structure; D012717:Sesquiterpenes / Q000737:chemistry* / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D007783:Lactones; D012717:Sesquiterpenes