Small molecules keep mitotic kinases in check.
The remarkable progress in the discovery of small molecules that target protein kinases continues, and two recent reports have described alternative approaches to this task: homology modeling and phenotype-based screening. Compounds targeting the nucleotide binding pockets of polo-like kinases in particular provide significant new insights into the molecular mechanisms controlling cell-division phenotypes.
Strebhardt
Klaus
K
Department of Obstetrics and Gynecology, School of Medicine, J. W. Goethe-University, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany. strebhardt@em.uni-frankfurt.de
D001665:Binding Sites / Q000187:drug effects / Q000502:physiology; D008938:Mitosis / Q000187:drug effects / Q000502:physiology*; D047428:Protein Kinase Inhibitors / Q000737:chemistry* / Q000494:pharmacology; D011494:Protein Kinases / Q000378:metabolism*
D047428:Protein Kinase Inhibitors; D011494:Protein Kinases