Membranoproliferative glomerulonephritis in a patient with Wilson's disease.
Wilson's disease is an autosomal recessive disorder of hepatobiliary copper metabolism. Glomerular diseases can ensue during the course of Wilson's disease and membranous nephropathy is the eventual pathology in the majority of these cases. Membranoproliferative glomerulonephritis (MPGN) has rarely been reported in patients with Wilson's disease. Further, in this report, we present a patient with Wilson's disease who had developed MPGN during follow-up due to D-penicillamine therapy. This case is presented to draw attention to the rare association of Wilson's disease and MPGN and to discuss the possible underlying causes.
Ozçakar
Z Birsin
ZB
Department of Pediatric Nephrology, Ankara University Medical School, Ankara, Turkey. zbozcakar@yahoo.com
Ekim
Mesiha
M
Ensari
Arzu
A
Kuloglu
Zarife
Z
Yüksel
Selçuk
S
Acar
Banu
B
Kirsaçlioglu
Ceyda
C
Kansu
Aydan
A
Yalçinkaya
Fatoş
F
Girgin
Nurten
N
D000293:Adolescent; D002614:Chelating Agents / Q000008:administration & dosage / Q000009:adverse effects*; D015432:Glomerulonephritis, Membranoproliferative / Q000139:chemically induced* / Q000473:pathology; D006527:Hepatolenticular Degeneration / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D008297:Male; D010396:Penicillamine / Q000008:administration & dosage / Q000009:adverse effects*
D002614:Chelating Agents; D010396:Penicillamine