Terbinafine-induced hepatic failure requiring liver transplantation.
Drug-induced liver disease accounts for about 50% of acute or subacute liver failure in the United States. United Network of Organ Sharing (UNOS) data suggest 8%-20% of liver transplantation in this country per year is for fulminant liver failure due to drugs. Even though the most common medication implicated in acute liver injury is acetaminophen (75%), there are numerous other drugs that are responsible for acute and chronic liver injury. A variety of antifungal medications are known to cause a wide range of liver injury from a mild hepatocellular-cholestatic injury pattern to acute/subacute liver failure. Terbinafine is one of the antifungals that have been associated with such liver injuries. We report a case of terbinafine-induced severe liver failure requiring liver transplantation.
Perveze
Zeeshan
Z
Piedmont Transplant Services, Piedmont Hospital, Atlanta, GA 30342, USA.
Johnson
Mark W
MW
Rubin
Raymond A
RA
Sellers
Marty
M
Zayas
Carlos
C
Jones
Jody L
JL
Cross
Rosemary
R
Thomas
Kimberly
K
Butler
Bradley
B
Shrestha
Roshan
R
D000082:Acetaminophen / Q000494:pharmacology; D000935:Antifungal Agents / Q000009:adverse effects*; D001652:Bile Ducts / Q000473:pathology; D002779:Cholestasis / Q000209:etiology; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000473:pathology; D017114:Liver Failure, Acute / Q000139:chemically induced*; D016031:Liver Transplantation / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009281:Naphthalenes / Q000009:adverse effects*; D000077291:Terbinafine
D000935:Antifungal Agents; D009281:Naphthalenes; D000082:Acetaminophen; D000077291:Terbinafine