title: Bioactive constituents from Chinese natural medicines. XX. Inhibitors of antigen-induced degranulation in RBL-2H3 cells from the seeds of Psoralea corylifolia.
abstract: The ethyl acetate-soluble fraction of the methanolic extract from the seeds of Psoralea corylifolia was found to inhibit the release of beta-hexosaminidase, as a marker of antigen-IgE-induced degranulation in RBL-2H3 cells. Sixteen constituents were isolated from the ethyl acetate-soluble fraction and several constituents, Delta(1),3-hydroxybakuchiol (IC(50) = 49 microM), Delta(3),2-hydroxybakuchiol (69 microM, bavachin (58 microM), and psoralidin (ca. 100 microM), showed inhibitory activities against the antigen-induced degranulation.
authors.affiliation: Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto 607-8412, Japan.
authors.forename: Hisashi
authors.initials: H
authors.lastname: Matsuda
authors.forename: Sachiko
authors.initials: S
authors.lastname: Sugimoto
authors.forename: Toshio
authors.initials: T
authors.lastname: Morikawa
authors.forename: Koudai
authors.initials: K
authors.lastname: Matsuhira
authors.forename: Eri
authors.initials: E
authors.lastname: Mizuguchi
authors.forename: Seikou
authors.initials: S
authors.lastname: Nakamura
authors.forename: Masayuki
authors.initials: M
authors.lastname: Yoshikawa
mesh_terms: D015550:Cell Degranulation / Q000187:drug effects* / Q000276:immunology; D002460:Cell Line; D002851:Chromatography, High Pressure Liquid; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry / Q000379:methods; D008516:Medicine, Chinese Traditional; D029907:Psoralea / Q000737:chemistry* / Q000196:embryology; D012639:Seeds / Q000737:chemistry*; D001619:beta-N-Acetylhexosaminidases / Q000037:antagonists & inhibitors / Q000378:metabolism
chemical_list: D001619:beta-N-Acetylhexosaminidases