title: Recombinant luteinizing hormone supplementation to recombinant follicle-stimulation hormone during induced ovarian stimulation in the GnRH-agonist protocol: a meta-analysis.
abstract: OBJECTIVE
  to compare the efficacy of recombinant LH supplementation for controlled ovarian stimulation in recombinant FSH and GnRH-agonist protocol.
  
  
  METHODS
  Search strategies included on-line surveys of databases. The fixed effects model was used for odds ratio and effect size (weighted mean difference). Four trials fulfilled the inclusion criteria.
  
  
  RESULTS
  a fewer days of stimulation (p<0.0001), a fewer total amount of r-FSH administered (p<0.0001) and a higher serum estradiol levels on the day of hCG administration (p<0.0001) were observed for the r-LH supplementation protocol. However, differences were not observed in number of oocyte retrieved, number of mature oocytes, clinical pregnancy per oocyte retrieval, implantation and miscarriage rates.
  
  
  CONCLUSIONS
  more randomized controlled trials are necessary before evidence-based recommendations regarding exogenous LH supplementation in ovarian stimulation protocols with FSH and GnRH-agonist for assisted reproduction treatment can be provided.
authors.affiliation: Center for Human Reproduction Prof. Franco Junior, Ribeirão Preto, SP, Brazil.
authors.forename: João Batista A
authors.initials: JB
authors.lastname: Oliveira
authors.forename: Ana Lucia
authors.initials: AL
authors.lastname: Mauri
authors.forename: Claudia G
authors.initials: CG
authors.lastname: Petersen
authors.forename: Anice M C
authors.initials: AM
authors.lastname: Martins
authors.forename: João
authors.initials: J
authors.lastname: Cornicelli
authors.forename: Mario
authors.initials: M
authors.lastname: Cavanha
authors.forename: Anagloria
authors.initials: A
authors.lastname: Pontes
authors.forename: Ricardo L R
authors.initials: RL
authors.lastname: Baruffi
authors.forename: José G
authors.initials: JG
authors.lastname: Franco
mesh_terms: D005260:Female; D005307:Fertilization in Vitro; D005640:Follicle Stimulating Hormone / Q000235:genetics / Q000378:metabolism / Q000627:therapeutic use*; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists*; D006801:Humans; D007986:Luteinizing Hormone / Q000235:genetics / Q000378:metabolism* / Q000627:therapeutic use; D010062:Ovulation Induction / Q000379:methods*; D011994:Recombinant Proteins / Q000235:genetics / Q000378:metabolism / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D011994:Recombinant Proteins; D007987:Gonadotropin-Releasing Hormone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone