title: [Current approaches to intraoperative diagnosis and treatment of low cardiac output during cardiosurgical operations].
abstract: The paper deals with the development of a diagnostic and therapeutic algorithm of intraoperative heart failure during cardiosurgical operations on the basis of evaluation of systolic and diastolic functions of the left and right ventricles. The study included 101 patients with low cardiac output in the postperfusion period. All the patients suffered from coronary heart disease and they underwent myocardial revascularizing operations under extracorporeal circulation. In all the patients, in addition to traditional hemodynamic parameters (heart rate, blood pressure, central venous pressure), the functional status of the left and right ventricles was evaluated by transesophageal Doppler echocardiography (TED echoCG) and the thermodilution technique using a Swan-Ganz catheter having a prompt thermistor. Evaluating the diastolic and diastolic functions of the right and left ventricles makes it possible to identify 2 types of left and right ventricular failure: 1) that due to systolic dysfunction and 2) that due to concomitance of systolic and diastolic dysfunctions. Dobutrex (5-7.5 microg/kg/min) should be used in right ventricular systolic dysfunction. Amrinone (5-10 microg/kg/min) should be given to patients with concomitance of systolic and diastolic dysfunction; in this situation, a combination of dobutrex and nitroglycerin (100-150 ng/kg/min) may be used. The drugs of choice in impaired left ventricular systolic function are epinephrine (30-100 ng/kg/min), dopamine (5-10 microg/kg/min), or dobutrex (5-7.5 microg/kg/min). Their combination with sodium nitroprusside can enhance the efficiency of therapy. In patients with left ventricular failure caused by systolic and diastolic dysfunction, epinephrine, dopamine, or dobutrex may be combined with amrinone (5-10 microg/kg/min) or nitroglycerin (100-150 ng/kg/min).
authors.forename: A G
authors.initials: AG
authors.lastname: Iavorovskiĭ
authors.forename: E V
authors.initials: EV
authors.lastname: Flerov
authors.forename: V A
authors.initials: VA
authors.lastname: Sandrikov
authors.forename: A A
authors.initials: AA
authors.lastname: Buniatian
mesh_terms: D000676:Amrinone / Q000627:therapeutic use; D001794:Blood Pressure / Q000187:drug effects; D002303:Cardiac Output, Low / Q000175:diagnosis* / Q000188:drug therapy*; D006348:Cardiac Surgical Procedures; D002316:Cardiotonic Agents / Q000627:therapeutic use*; D003327:Coronary Disease / Q000601:surgery*; D003971:Diastole / Q000187:drug effects; D004280:Dobutamine / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007431:Intraoperative Complications / Q000175:diagnosis* / Q000188:drug therapy*; D008297:Male; D005996:Nitroglycerin / Q000627:therapeutic use; D009599:Nitroprusside / Q000627:therapeutic use; D013318:Stroke Volume / Q000187:drug effects; D013599:Systole / Q000187:drug effects; D014665:Vasodilator Agents / Q000627:therapeutic use*; D018487:Ventricular Dysfunction, Left / Q000175:diagnosis / Q000188:drug therapy; D018497:Ventricular Dysfunction, Right / Q000175:diagnosis / Q000188:drug therapy
chemical_list: D002316:Cardiotonic Agents; D014665:Vasodilator Agents; D009599:Nitroprusside; D004280:Dobutamine; D005996:Nitroglycerin; D000676:Amrinone