title: Heritability of bipolar EEG spectra in a large sib-pair population.
abstract: The additive genetic heritability of both monopolar and bipolar EEG spectral power in a sample of 305 non-twin sibships comprising 690 individuals (age range 7-65) was estimated in order to investigate their regional variation. The heritabilities of the bipolar EEG spectral power ranged from 0.10 to 0.63 in 38 electrode-pairs, and those of monopolar power ranged from 0.23 to 0.68 in 19 electrodes in six frequency bands from theta to high beta. The bipolar data shows significantly greater topographic variation compared to that of the monopolar data. The mean of bivariate genetic correlations were consistently lower for the bipolar data and the coefficients of variation consistently higher when compared to those of the monopolar data for each of the frequency bands. The results from the bipolar derivations are in greater accord with genetic findings in brain anatomy and show the possibility of multiple genetic sources for the phenotypic variability of EEG activity.
authors.affiliation: Neurodynamics Laboratory, SUNY Downstate Medical Center, Brooklyn, NY, USA.
authors.forename: Yongqiang
authors.initials: Y
authors.lastname: Tang
authors.forename: David B
authors.initials: DB
authors.lastname: Chorlian
authors.forename: Madhavi
authors.initials: M
authors.lastname: Rangaswamy
authors.forename: Sean
authors.initials: S
authors.lastname: O'Connor
authors.forename: Robert
authors.initials: R
authors.lastname: Taylor
authors.forename: John
authors.initials: J
authors.lastname: Rohrbaugh
authors.forename: Bernice
authors.initials: B
authors.lastname: Porjesz
authors.forename: Henri
authors.initials: H
authors.lastname: Begleiter
mesh_terms: D000513:Alpha Rhythm; D000704:Analysis of Variance; D001611:Beta Rhythm; D001714:Bipolar Disorder / Q000235:genetics* / Q000503:physiopathology*; D001931:Brain Mapping; D003866:Depressive Disorder / Q000235:genetics* / Q000503:physiopathology; D004569:Electroencephalography; D006801:Humans; D008957:Models, Genetic; D035781:Siblings