Distinct requirements for interleukin-6 in airway inflammation induced by diesel exhaust in mice.
To clarify the possible role of interleukin-6 in aggravation of inflammatory responses in diesel exhaust-exposed mice, we compared the infiltration of inflammatory cells and the production of chemokines between interleukin-6-deficient and wild-type mice following 0, 1.0, or 3.0 mg diesel particles/m3 diesel exhaust inhalation for 4 weeks. Exposure to diesel exhaust significantly increased the number of inflammatory cells and the amount of CCL17 and CXCL3 in bronchoalveolar lavage fluids from wild-type mice, but not in interleukin-6-deficient mice. These findings suggest that interleukin-6 plays a critical role in airway inflammatory responses induced by diesel exhaust inhalation.
Fujimaki
Hidekazu
H
National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan. fujimaki@nies.go.jp
Kurokawa
Yoshika
Y
Yamamoto
Shoji
S
Satoh
Masahiko
M
D000818:Animals; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology; D002478:Cells, Cultured; D018925:Chemokines / Q000096:biosynthesis; D019743:Chemokines, CXC; D016207:Cytokines / Q000096:biosynthesis; D007249:Inflammation / Q000378:metabolism* / Q000473:pathology*; D015850:Interleukin-6 / Q000235:genetics / Q000502:physiology*; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D012140:Respiratory Tract Diseases / Q000473:pathology*; D001335:Vehicle Emissions / Q000633:toxicity*
D018925:Chemokines; D019743:Chemokines, CXC; C577095:Cxcl3 protein, mouse; D016207:Cytokines; D015850:Interleukin-6; D001335:Vehicle Emissions