title: Cacalol derivatives from Roldana angulifolia.
abstract: Four new modified eremophilanes, angulifolide (1) and angulifolins A-C (2-4), and two new triacetylglucosides (7 and 8) were isolated from Roldana angulifolia, together with several known compounds. The structures of the new compounds were elucidated by spectroscopic analysis and chemical reactions. The absolute configuration of compounds 2 and 3 was established by Mosher ester methodology. Cytotoxicity against selected human cancer cell lines was determined for the more abundant isolated metabolites.
authors.affiliation: Instituto de Química and Instituto de Biología, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, Coyoacán 04510, D.F., México.
authors.forename: Amira
authors.initials: A
authors.lastname: Arciniegas
authors.forename: Ana-L
authors.initials: AL
authors.lastname: Pérez-Castorena
authors.forename: José Luis
authors.initials: JL
authors.lastname: Villaseñor
authors.forename: Alfonso
authors.initials: A
authors.lastname: Romo de Vivar
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019659:Asteraceae / Q000737:chemistry*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D008800:Mexico; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D005960:Glucosides; D012717:Sesquiterpenes; C516380:angulifolide; C516377:angulifolin A; C516379:angulifolin B; C516378:angulifolin C; C497192:cacalol