title: Antifungal constituents from the Chinese moss Homalia trichomanoides.
abstract: Bioautographic assay on TLC plates was adopted to guide the fractionation of the Et2O extract of Homalia trichomanoides (Hedw.) B. S. G., which led to the isolation of the novel p-terphenyl derivative trichomanin (= 4,4''-dihydroxy-1,1':4',1''-terphenyl-2',3',5',6'-tetrayl tetrakis(phenylacetate); 1), together with five known compounds: 3alpha-methoxyserrat-14-en-21beta-ol (2), 3beta-methoxyserrat-14-en-21beta-ol (3), 3beta-methoxyserrat-14-en-21-one (4), atranorin (5), and methyl 2,4-dihydroxy-3,6-dimethylbenzoate (6). Their structures were determined on the basis of spectral data (1D- and 2D-NMR, MS), X-ray crystallographic analysis, and chemical transformation. Compounds 3, 5, and 6 exhibited antifungal activity against Candida albicans, with minimum inhibitory doses (MID) of 2.0, 2.0, and 0.6 microg, respectively.
authors.affiliation: School of Pharmaceutical Sciences, Shandong University, No. 44 West Wenhua Road, Jinan 250012, PR China.
authors.forename: Xiao-ning
authors.initials: XN
authors.lastname: Wang
authors.forename: Wen-tao
authors.initials: WT
authors.lastname: Yu
authors.forename: Hong-xiang
authors.initials: HX
authors.lastname: Lou
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry* / Q000494:pharmacology*; D044002:Bryophyta / Q000737:chemistry*; D002176:Candida albicans / Q000187:drug effects; D002681:China; D008958:Models, Molecular; D015394:Molecular Structure
chemical_list: D000935:Antifungal Agents