title: Anaesthetic and cardiopulmonary effects of intramuscular morphine, medetomidine and ketamine administered to telemetered cats.
abstract: The quality and duration of anaesthesia, cardiorespiratory effects and recovery characteristics of a morphine, medetomidine, ketamine (MMK) drug combination were determined in cats. Six healthy, adult female cats were administered 0.2 mg/kg morphine sulphate, 60 microg/kg medetomidine hydrochloride, and 5 mg/kg ketamine hydrochloride intramuscularly. Atipamezole was administered intramuscularly at 120 min after MMK administration. Time to lateral recumbency, intubation, extubation and sternal recumbency were recorded. Cardiorespiratory variables and response to a noxious stimulus were recorded before and at 3 min and 10 min increments after drug administration until sternal recumbency. The time to lateral recumbency and intubation were 1.9+/-1.2 and 4.3+/-1.2 min, respectively. Body temperature and haemoglobin saturation with oxygen remained unchanged compared to baseline values throughout anaesthesia. Respiratory rate, tidal volume, minute volume, heart rate, and blood pressure were significantly decreased during anaesthesia compared to baseline values. One cat met criteria for hypotension (systolic blood pressure <90 mmHg). End tidal carbon dioxide increased during anaesthesia compared to baseline values. All but one cat remained non-responsive to noxious stimuli from 3 to 120 min. Time to extubation and sternal recumbency following atipamezole were 2.9+/-1.1 and 4.7+/-1.0 min, respectively. MMK drug combination produced excellent short-term anaesthesia and analgesia with minimal cardiopulmonary depression. Anaesthesia lasted for at least 120 min in all but one cat and was effectively reversed by atipamezole.
authors.affiliation: Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, 601 Vernon Tharp Street, Columbus, OH 43210-1089, United States.
authors.forename: Ashley J
authors.initials: AJ
authors.lastname: Wiese
authors.forename: William W
authors.initials: WW
authors.lastname: Muir
mesh_terms: D000701:Analgesics, Opioid / Q000008:administration & dosage; D000704:Analysis of Variance; D000758:Anesthesia / Q000662:veterinary*; D019162:Anesthetics, Combined / Q000008:administration & dosage; D000778:Anesthetics, Dissociative / Q000008:administration & dosage; D000818:Animals; D002415:Cats / Q000502:physiology*; D002492:Central Nervous System Depressants / Q000008:administration & dosage*; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006993:Hypnotics and Sedatives / Q000008:administration & dosage; D007273:Injections, Intramuscular / Q000662:veterinary; D007649:Ketamine / Q000008:administration & dosage*; D020926:Medetomidine / Q000008:administration & dosage*; D009020:Morphine / Q000008:administration & dosage*; D012119:Respiration / Q000187:drug effects
chemical_list: D000701:Analgesics, Opioid; D019162:Anesthetics, Combined; D000778:Anesthetics, Dissociative; D002492:Central Nervous System Depressants; D006993:Hypnotics and Sedatives; D007649:Ketamine; D009020:Morphine; D020926:Medetomidine