title: Aortic dissection complicating pregnancy following prophylactic aortic root replacement in a woman with Marfan syndrome.
abstract: Prophylactic aortic root replacement is the main factor explaining the increase in median probability of survival in Marfan syndrome (MFS) patients. In women with MFS, earlier root replacement has been suggested as a strategy to facilitate safe pregnancy. However, in this case report a pregnant patient with MFS who sustained a Type B aortic dissection in her second trimester, with fatal outcome, despite having had a prophylactic aortic root replacement five months prior to conception is described.
authors.forename: Colleen D
authors.initials: CD
authors.lastname: McDermott
authors.forename: Mathew
authors.initials: M
authors.lastname: Sermer
authors.forename: Samuel C
authors.initials: SC
authors.lastname: Siu
authors.forename: Tirone E
authors.initials: TE
authors.lastname: David
authors.forename: Jack M
authors.initials: JM
authors.lastname: Colman
mesh_terms: D000328:Adult; D000784:Aortic Dissection / Q000209:etiology*; D001014:Aortic Aneurysm / Q000209:etiology*; D001021:Aortic Valve / Q000601:surgery*; D017809:Fatal Outcome; D005260:Female; D005313:Fetal Death; D006350:Heart Valve Prosthesis; D006801:Humans; D008382:Marfan Syndrome / Q000150:complications / Q000601:surgery*; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000601:surgery*; D011262:Pregnancy Trimester, Second