title: [Role of therapeutics for allergic diseases in targeting histamine H1 receptor gene expression].
abstract: Histamine H(1) receptors are down-regulated as one step in receptor desensitization. Five phosphorylation sites of the H(1) receptor seem to play a key role in receptor down-regulation. In contrast, an increase in the H(1) receptor expression level following its mRNA elevation was found in the nasal mucosa in hypersensitivity model rats. Up-regulation of the H(1) receptor was induced by the direct stimulation of the H(1) receptor. H(1) receptor up-regulation was suppressed by pretreatment with antiallergic agents.
authors.affiliation: Department of Molecular Pharmacology, Graduate School of Health Biosciences, The University of Tokushima, Tokushima City, Japan. hfukui@ph.tokushima-u.ac.jp
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Fukui
mesh_terms: D000818:Animals; D018926:Anti-Allergic Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D016207:Cytokines / Q000235:genetics / Q000378:metabolism; D015536:Down-Regulation / Q000187:drug effects; D004365:Drugs, Chinese Herbal / Q000494:pharmacology / Q000627:therapeutic use; D005786:Gene Expression Regulation / Q000187:drug effects; D006640:Histidine Decarboxylase / Q000235:genetics / Q000378:metabolism; D006801:Humans; D006967:Hypersensitivity / Q000188:drug therapy*; D009297:Nasal Mucosa / Q000378:metabolism; D008517:Phytotherapy; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D011969:Receptors, Histamine H1 / Q000235:genetics* / Q000378:metabolism; D015854:Up-Regulation / Q000187:drug effects
chemical_list: D018926:Anti-Allergic Agents; D016207:Cytokines; D004365:Drugs, Chinese Herbal; D012333:RNA, Messenger; D011969:Receptors, Histamine H1; D006640:Histidine Decarboxylase