Built-in axial base binding on phenanthroline-strapped zinc(II) and iron(III) porphyrins.
In addition to the need for functional models of cytochrome c oxidase, structural models are still required for a better understanding of the small reorganizations occurring during the catalytic cycle. An efficient synthetic approach has been designed to prepare several phenanthroline-strapped porphyrins, two of them bearing two pendant imidazoles. These built-in bases are both potentially able to act as axial bases for the metalloporphyrin and as complementary ligands for copper if necessary. Diamagnetic zinc(II) was used to demonstrate that the distal/proximal selectivity demonstrated by exogenic bases binding studies can be extended to the coordination of iron(III). Combination of EPR and paramagnetic 1H NMR shows that the imidazole binding on the zinc species can be further extended to the iron(III) species in dilute conditions.
Melin
Frédéric
F
Chimie des Ligands à Architecture Contrôlée, LC3 CNRS-ULP, Institut Le Bel, 4 rue Blaise Pascal, 67070 Strasbourg Cedex, France.
Choua
Sylvie
S
Bernard
Maxime
M
Turek
Philippe
P
Weiss
Jean
J
D003300:Copper / Q000737:chemistry; D045304:Cytochromes c / Q000737:chemistry* / Q000378:metabolism*; D007501:Iron / Q000737:chemistry*; D008956:Models, Chemical; D015394:Molecular Structure; D010618:Phenanthrolines / Q000737:chemistry*; D011166:Porphyrins / Q000737:chemistry*; D015032:Zinc / Q000737:chemistry*
D010618:Phenanthrolines; D011166:Porphyrins; D003300:Copper; D045304:Cytochromes c; D007501:Iron; D015032:Zinc