High affinity not in the vicinity?
Functional interactions between the p75 neurotrophin receptor (p75NTR) and the Trk receptors were demonstrated several years ago, but their mechanistic basis remains uncertain. In this issue of Neuron, Wehrman et al. provide a three-dimensional structure of the full TrkA ectodomain complexed to NGF and examine the possibility of a ternary p75NTR-NGF-TrkA complex.
Barker
Philip A
PA
Centre for Neuronal Survival, Montreal Neurological Institute, McGill University, 3801 University Avenue, Montreal, Quebec H3A 2B4, Canada. phil.barker@mcgill.ca
D000818:Animals; D001665:Binding Sites / Q000502:physiology; D006801:Humans; D008024:Ligands; D046911:Macromolecular Substances / Q000737:chemistry / Q000378:metabolism; D020932:Nerve Growth Factor / Q000737:chemistry* / Q000378:metabolism; D009474:Neurons / Q000378:metabolism*; D017434:Protein Structure, Tertiary / Q000502:physiology; D020800:Receptor, Nerve Growth Factor / Q000737:chemistry* / Q000378:metabolism; D020917:Receptor, trkA / Q000737:chemistry* / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology
D008024:Ligands; D046911:Macromolecular Substances; D020800:Receptor, Nerve Growth Factor; D020932:Nerve Growth Factor; D020917:Receptor, trkA