title: Pretransplant soluble CD30 level has limited effect on acute rejection, but affects graft function in living donor kidney transplantation.
abstract: BACKGROUND
  Serum soluble CD30 (sCD30) levels might be a useful marker of immunologic status in pre transplant (Tx) recipients. We retrospectively correlated preTx sCD30 levels (high versus low) on postTx graft survival, incidence of acute rejection, and graft function using stored preTx serum.
  
  
  METHODS
  Of 254 recipients who underwent kidney Tx, 120 recipients were enrolled under the uniform criteria (living donor, age >25 years, viral hepatitis free, diabetes free).
  
  
  RESULTS
  The preTx sCD30 was not significantly associated with differences in graft survival rate during 47.5+/-11.4 months of follow-up (P = 0.5901). High sCD30 (> or =115 U/ml) was associated with a higher incidence of clinically or pathologically defined acute rejection than low sCD30, but the difference was not statistically significant (33.9% vs. 22.4%, P = 0.164). The response rate to antirejection therapy in patients with high sCD30 was inferior to those with low sCD30, but also was not statistically significant (33.3% vs. 7.7%, P = 0.087). However, mean serum creatinine levels in high sCD30 patients at one month, one year, and three years postTx were significantly different from those with low sCD30 (P < 0.05). In multiple regression analysis, acute rejection episodes, donor age, kidney weight/recipient body weight ratio, and preTx sCD30 levels were independent variables affecting the serum creatinine level three years postTx.
  
  
  CONCLUSIONS
  PreTx sCD30 level has a limited effect on the incidence of acute rejection and response to antirejection treatment, but inversely and independently affects serum creatinine level after living donor kidney transplantation.
authors.affiliation: Department of Surgery, Yonsei University College of Medicine, Seoul, South Korea.
authors.forename: Myoung Soo
authors.initials: MS
authors.lastname: Kim
authors.forename: Hae Jin
authors.initials: HJ
authors.lastname: Kim
authors.forename: Soon Il
authors.initials: SI
authors.lastname: Kim
authors.forename: Hyung Joon
authors.initials: HJ
authors.lastname: Ahn
authors.forename: Man Ki
authors.initials: MK
authors.lastname: Ju
authors.forename: Hyun Jung
authors.initials: HJ
authors.lastname: Kim
authors.forename: Kyung Ock
authors.initials: KO
authors.lastname: Jeon
authors.forename: Yu Seun
authors.initials: YS
authors.lastname: Kim
mesh_terms: D000328:Adult; D003404:Creatinine / Q000097:blood*; D005260:Female; D006084:Graft Rejection / Q000453:epidemiology*; D006085:Graft Survival / Q000276:immunology; D006801:Humans; D015994:Incidence; D017730:Ki-1 Antigen / Q000097:blood* / Q000276:immunology; D007668:Kidney / Q000502:physiology*; D016030:Kidney Transplantation / Q000276:immunology*; D019520:Living Donors; D008297:Male; D008875:Middle Aged
chemical_list: D017730:Ki-1 Antigen; D003404:Creatinine