Tea catechins attenuate chronic ventricular remodeling after myocardial ischemia in rats.
Tea catechins have many biological functions; these effects are induced by the suppression of several inflammatory factors. However, the effects of catechins on ventricular remodeling after myocardial ischemia have not been well investigated. To test the hypothesis that catechins can attenuate chronic ventricular remodeling after myocardial ischemia, we performed oral administration of catechins into rat myocardial ischemia models. We analyzed the mechanisms using physiological, pathological and molecular examinations. Although severe myocardial fibrosis with enhancement of inflammatory factors were observed in the non-treated ischemia group on day 28, catechins attenuated these changes with suppressed NF-kappaB and matrix metalloproteinases without systemic adverse effects. Catechins are potent for the suppression of chronic ventricular remodeling after myocardial ischemia because they are critically involved in the suppression of several inflammatory genes.
Suzuki
Jun-ichi
J
Department of Cardiovascular Medicine, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo-ku, Tokyo 113-8519, Japan. jsuzuki.cvm@tmd.ac.jp
Ogawa
Masahito
M
Maejima
Yasuhiro
Y
Isobe
Kazuya
K
Tanaka
Hiroyuki
H
Sagesaka
Yuko M
YM
Isobe
Mitsuaki
M
D000818:Animals; D002392:Catechin / Q000737:chemistry / Q000494:pharmacology*; D005786:Gene Expression Regulation / Q000187:drug effects*; D007249:Inflammation / Q000378:metabolism / Q000473:pathology; D018836:Inflammation Mediators / Q000378:metabolism*; D008297:Male; D017202:Myocardial Ischemia / Q000378:metabolism* / Q000473:pathology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013662:Tea / Q000737:chemistry; D020257:Ventricular Remodeling / Q000187:drug effects*
D018836:Inflammation Mediators; D013662:Tea; D002392:Catechin