Can the peroxosuccinate complex in the catalytic cycle of taurine/alpha-ketoglutarate dioxygenase (TauD) act as an alternative oxidant?
Density functional theoretical studies on the catalytic properties of the peroxosuccinate intermediate in the catalytic cycle of taurine/alpha-ketoglutarate dioxygenase suggest that it cannot act as a second oxidant.
de Visser
Sam P
SP
The Manchester Interdisciplinary Biocenter and the School of Chemical Engineering and Analytical Science, 131 Princess Street, Manchester, M1 7DN, UK. sam.devisser@manchester.ac.uk
D000475:Alkenes / Q000737:chemistry; D002384:Catalysis; D020134:Catalytic Domain; D004852:Epoxy Compounds / Q000737:chemistry; D006900:Hydroxylation; D007501:Iron / Q000737:chemistry; D006899:Mixed Function Oxygenases / Q000737:chemistry*; D008956:Models, Chemical; D015394:Molecular Structure; D016877:Oxidants / Q000737:chemistry*; D010084:Oxidation-Reduction; D010100:Oxygen / Q000737:chemistry; D010545:Peroxides / Q000737:chemistry*; D019802:Succinic Acid / Q000737:chemistry*; D013816:Thermodynamics
D000475:Alkenes; D004852:Epoxy Compounds; D016877:Oxidants; D010545:Peroxides; D019802:Succinic Acid; C013658:propylene; D007501:Iron; D006899:Mixed Function Oxygenases; C433064:taurine-alpha-ketoglutarate dioxygenase; D010100:Oxygen