title: Antiviral activity of nucleoside analogues against SARS-coronavirus (SARS-coV).
abstract: The recent outbreak of severe acute respiratory syndrome (SARS), which is an acute respiratory illness, is caused by newly discovered SARS coronavirus (SARS-CoV). Herein we describe the antiviral activity of several classes of nucleoside analogues evaluated against SARS-CoV in Vero 76 cells, some of which exhibited moderate activity.
authors.affiliation: The University of Georgia, College of Pharmacy, Athens, GA, USA. dchu@rx.uga.edu
authors.forename: Chung K
authors.initials: CK
authors.lastname: Chu
authors.forename: Srinivas
authors.initials: S
authors.lastname: Gadthula
authors.forename: Xin
authors.initials: X
authors.lastname: Chen
authors.forename: Hyunah
authors.initials: H
authors.lastname: Choo
authors.forename: Sureyya
authors.initials: S
authors.lastname: Olgen
authors.forename: Dale L
authors.initials: DL
authors.lastname: Barnard
authors.forename: Robert W
authors.initials: RW
authors.lastname: Sidwell
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology*; D002522:Chlorocebus aethiops; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009705:Nucleosides / Q000737:chemistry / Q000494:pharmacology*; D045473:Severe acute respiratory syndrome-related coronavirus / Q000187:drug effects*; D013329:Structure-Activity Relationship; D014709:Vero Cells; D014779:Virus Replication / Q000187:drug effects
chemical_list: D000998:Antiviral Agents; D009705:Nucleosides