Microgravity dependence of excitable biological and physicochemical media.
Neuronal tissue and especially the central nervous system (CNS) is an excitable medium. Self-organisation, pattern formation, and propagating excitation waves as typical characteristics in excitable media consequently have been found in neuronal tissue. The properties of such phenomena in excitable media do critically depend on the parameters (i.e., electromagnetic fields, temperature, chemical drugs) of the system and on small external forces to which gravity belongs. The spreading depression, a propagating excitation depression wave of neuronal activity, is one of the best described of the those wave phenomena in the CNS. Especially in the retina as a true part of the CNS it can be easily observed with optical techniques due to the high intrinsic optical signal of this tissue. Another of such waves in neuronal tissue is the propagating action potential in nerve fibres. In this paper, data from our laboratories concerning the influence of gravity on the velocity of propagating waves in excitable media are summarized mainly in terms of the retinal spreading depression and propagating action potentials. Additionally, we have used waves in gels of the Belousov-Zhabotinsky reaction as the physicochemical model system of biological activity as the properties of these waves follow the same theories as the spreading depression and action potentials and they have some striking similarities in wave behavior. Thus propagating Belousov-Zhabotinsky waves are described by their gravity dependence.
Hanke
W
W
Institute of Physiology, University of Hohenheim, Stuttgart, Federal Republic of Germany. hanke@uni-hohenheim.de
Fernandes de Lima
V M
VM
Wiedemann
M
M
Meissner
K
K
D000200:Action Potentials; D000818:Animals; D002645:Chickens; D013181:Cortical Spreading Depression; D004574:Electromagnetic Fields; D009474:Neurons / Q000502:physiology*; D009924:Organ Culture Techniques / Q000295:instrumentation; D012032:Refractory Period, Electrophysiological; D012160:Retina / Q000166:cytology / Q000502:physiology*; D058428:Silica Gel; D012822:Silicon Dioxide / Q000737:chemistry*; D013026:Space Flight / Q000295:instrumentation*; D013997:Time Factors; D014741:Video Recording; D014893:Weightlessness
D058428:Silica Gel; D012822:Silicon Dioxide