title: Prognostic significance of plasma resistin levels in patients with atherothrombotic ischemic stroke.
abstract: BACKGROUND
  Resistin (RSN) is an adipocytokine involved in insulin resistance, obesity and atherosclerosis. This study aimed to investigate the association between plasma RSN and outcome after ischemic stroke.
  
  
  METHODS
  RSN measured within 24 h after the event was related to functional outcome and 5-year survival in 211 subjects with first-ever atherothrombotic ischemic stroke. Prognosis was assessed by the Kaplan Meier and the Cox techniques.
  
  
  RESULTS
  The probabilities of death were 80.4%, 46.2% and 15.7% (p<0.001) for patients stratified according to tertiles of RSN (>30 ng/mL, 20-30 ng/mL and<20 ng/mL, respectively). The proportion of dependency (modified Rankin Scale score>or=3) was greater in 5-year survivors with RSN in the upper tertile (6/11 [54.5%]) compared to the middle (20/56 [35.7%]) and the lowest tertile (8/43 [18.6%]; p<0.01). C-reactive protein levels (hazard ratio [HR] 3.96 [95% CI 2.06, 8.91]; p<0.001), coronary heart disease (2.69 [1.62, 6.23]; p<0.001), RSN levels (2.12 [1.31, 5.08] p<0.001), National Institute of Health Stroke Scale score (2.02 [1.23, 4.49]; p<0.01) and age (1.84 [1.19, 3.93]; p<0.01) were independent predictors of death.
  
  
  CONCLUSIONS
  High plasma RSN appears to be associated with increased risk of 5-year mortality or disability after atherothrombotic ischemic stroke, independently of other adverse predictors.
authors.affiliation: Center for the Prevention of Cardiovascular Disease, Hygeias Melathron, Third University Department of Medicine, Medical School, Sotiria Hospital, Athens, Greece. sefstath@tellas.gr
authors.forename: Stamatis P
authors.initials: SP
authors.lastname: Efstathiou
authors.forename: Aphrodite G
authors.initials: AG
authors.lastname: Tsiakou
authors.forename: Dimitrios I
authors.initials: DI
authors.lastname: Tsioulos
authors.forename: Themistoklis N
authors.initials: TN
authors.lastname: Panagiotou
authors.forename: Angelos V
authors.initials: AV
authors.lastname: Pefanis
authors.forename: Apostolos D
authors.initials: AD
authors.lastname: Achimastos
authors.forename: Theodore D
authors.initials: TD
authors.lastname: Mountokalakis
mesh_terms: D000328:Adult; D000368:Aged; D050197:Atherosclerosis / Q000097:blood* / Q000401:mortality; D002545:Brain Ischemia / Q000097:blood* / Q000401:mortality; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D052243:Resistin / Q000097:blood*; D020521:Stroke / Q000097:blood* / Q000401:mortality
chemical_list: C499624:RETN protein, human; D052243:Resistin