In vitro and in vivo performance of a novel surface treatment to enhance osseointegration of endosseous implants.
OBJECTIVE
This article shows the in vitro and in vivo characterization of a new biomimetic treatment developed to enhance the osseointegration of titanium dental implants.


METHODS
A novel biomimetic treatment of titanium was developed. Its physicochemical properties and biologic and in vivo performance were considered and studied. Mineralization capability was assessed by soaking test in simulated body fluid solution, and cytocompatibility was assessed using osteoblast-like MG63 cell culture. Histomorphometric analysis was performed at 3 time points using a sheep animal model.


RESULTS
In vitro tests confirmed the biomimetic potential of the considered novel treatment. Histomorphometric analysis indicated its potential for rapid and good-quality osseointegration.


CONCLUSIONS
The in vitro and in vivo test results indicated that the proposed novel treatment possesses a significant potential to increase the rate of osteointegration of titanium for endosseous dental implants.
Chiesa
Roberto
R
Department of Chemistry, Materials, and Chemical Engineering G. Natta, Polyitecnico di Milano, Milan, Italy. roberto.chiesa@polimi.it
Giavaresi
Gianluca
G
Fini
Milena
M
Sandrini
Enrico
E
Giordano
Carmen
C
Bianchi
Andrea
A
Giardino
Roberto
R
D000704:Analysis of Variance; D000818:Animals; D040761:Biomimetic Materials / Q000633:toxicity; D001842:Bone and Bones / Q000601:surgery; D002118:Calcium / Q000032:analysis; D045744:Cell Line, Tumor; D020099:Coated Materials, Biocompatible / Q000633:toxicity; D045662:Dental Etching; D003758:Dental Implantation, Endosseous; D015921:Dental Implants; D017267:Dental Prosthesis Design; D004577:Electron Probe Microanalysis; D004595:Electroplating / Q000379:methods; D006801:Humans; D020007:Implants, Experimental; D016348:Osseointegration; D010006:Osteoblasts / Q000187:drug effects; D010710:Phosphates / Q000032:analysis; D012756:Sheep; D013499:Surface Properties; D014025:Titanium
D020099:Coated Materials, Biocompatible; D015921:Dental Implants; D010710:Phosphates; C009495:titanium dioxide; D014025:Titanium; D002118:Calcium