title: Deltaran prevents an adverse effect of emotional stress on the course of cerebral ischemia in low-resistant animals.
abstract: Local cerebral blood flow in the left hemisphere decreased most significantly in low-resistant Wistar rats preexposed to emotional stress. Deltaran selectively increased blood flow in the left hemisphere and improved blood supply to neuronal activity unit of the brain in these animals. This drug prevented progressive decrease in local cerebral blood flow in both hemispheres during the acute stage of ischemia. The effect of Deltaran was related to modulation of collateral blood flow and adequate blood supply to neuronal activity unit in the brain tissue. Deltaran decreased the mortality rate (by 62%) and alleviated the symptoms of cerebral ischemia. The positive effect of Deltaran was more pronounced in the left hemisphere.
authors.affiliation: Institute of Neurology, Russian Academy of Medical Sciences, Moscow.
authors.forename: I L
authors.initials: IL
authors.lastname: Konorova
authors.forename: I V
authors.initials: IV
authors.lastname: Gannushkina
authors.forename: E V
authors.initials: EV
authors.lastname: Koplik
authors.forename: A L
authors.initials: AL
authors.lastname: Antelava
mesh_terms: D000818:Animals; D002545:Brain Ischemia / Q000401:mortality / Q000473:pathology*; D003701:Delta Sleep-Inducing Peptide / Q000494:pharmacology / Q000627:therapeutic use*; D004338:Drug Combinations; D004569:Electroencephalography; D005998:Glycine / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012039:Regional Blood Flow / Q000187:drug effects; D013315:Stress, Psychological / Q000188:drug therapy* / Q000503:physiopathology*; D013687:Telencephalon / Q000098:blood supply*
chemical_list: D004338:Drug Combinations; C515717:deltaran; D003701:Delta Sleep-Inducing Peptide; D005998:Glycine