title: Molecular evolution of peptide methionine sulfoxide reductases (MsrA and MsrB): on the early development of a mechanism that protects against oxidative damage.
abstract: Methionine sulfoxide reductases, enzymes that reverse the oxidation of methionine residues, have been described in a wide range of species. The reduction of the diastereoisomers of oxidized methionine is catalyzed by two different monomeric methionine sulfoxide reductases (MsrA and MsrB) and is best understood as an evolutionary response to high levels of oxygen either in the Earth's atmosphere or possibly in more localized environments. Phylogenetic analyses of these proteins suggest that their distribution is the outcome of a complex history including many paralogy and lateral gene transfer events.
authors.affiliation: Facultad de Ciencias, UNAM, Apartado Postal 70-407, Cd. Universitaria, 04510 Mexico DF, México.
authors.forename: Luis
authors.initials: L
authors.lastname: Delaye
authors.forename: Arturo
authors.initials: A
authors.lastname: Becerra
authors.forename: Leslie
authors.initials: L
authors.lastname: Orgel
authors.forename: Antonio
authors.initials: A
authors.lastname: Lazcano
mesh_terms: D000818:Animals; D001426:Bacterial Proteins / Q000502:physiology; D019143:Evolution, Molecular; D006801:Humans; D051150:Methionine Sulfoxide Reductases; D008840:Microfilament Proteins; D018384:Oxidative Stress; D010088:Oxidoreductases / Q000502:physiology*; D010802:Phylogeny; D012336:RNA, Ribosomal, 16S; D012337:RNA, Ribosomal, 18S; D013559:Symbiosis; D014157:Transcription Factors
chemical_list: D001426:Bacterial Proteins; D008840:Microfilament Proteins; D012336:RNA, Ribosomal, 16S; D012337:RNA, Ribosomal, 18S; D014157:Transcription Factors; D010088:Oxidoreductases; C120376:MSRB2 protein, human; D051150:Methionine Sulfoxide Reductases; C027219:methionine sulfoxide reductase