title: A new era in periodontal and periimplant regeneration: use of growth-factor enhanced matrices incorporating rhPDGF.
abstract: A new, powerful off-the-shelf wound healing and bone regeneration technology termed growth-factor enhanced matrix (GEM) has recently become available for clinical use. This graft material consists of a concentrated solution of pure recombinant human platelet-derived growth factor (rhPDGF-BB), the synthetic form of the body's key natural wound healing stimulator PDGF-BB, and an osteoconductive (bone scaffold) matrix. This is the first available purified, recombinant (synthetic) growth factor product and is the result of over a decade of extensive research. Clinical and animal study results with this graft material demonstrate that it is capable of simultaneously promoting wound healing, regeneration of bone, and acceleration of gingival attach-plent gain in challenging periodontal and periimplant defects.
authors.affiliation: BioMimetic Therapeutics, Inc., Franklin, Tennessee, USA.
authors.forename: Samuel E
authors.initials: SE
authors.lastname: Lynch
authors.forename: Leslie
authors.initials: L
authors.lastname: Wisner-Lynch
authors.forename: Myron
authors.initials: M
authors.lastname: Nevins
authors.forename: Marc L
authors.initials: ML
authors.lastname: Nevins
mesh_terms: D016301:Alveolar Bone Loss / Q000601:surgery; D000818:Animals; D000077214:Becaplermin; D001857:Bone Matrix / Q000637:transplantation; D001861:Bone Regeneration / Q000187:drug effects; D018786:Bone Substitutes / Q000627:therapeutic use*; D015921:Dental Implants; D017823:Furcation Defects / Q000601:surgery; D005881:Gingiva / Q000187:drug effects; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods*; D006801:Humans; D010012:Osteogenesis / Q000187:drug effects; D010510:Periodontal Diseases / Q000601:surgery*; D010982:Platelet-Derived Growth Factor / Q000627:therapeutic use*; D020574:Proto-Oncogene Proteins c-sis; D011994:Recombinant Proteins; D023822:Tissue Engineering; D014945:Wound Healing / Q000187:drug effects
chemical_list: D018786:Bone Substitutes; D015921:Dental Implants; D010982:Platelet-Derived Growth Factor; D020574:Proto-Oncogene Proteins c-sis; D011994:Recombinant Proteins; D000077214:Becaplermin