title: Morphologic and functional features of the canine cruciate ligaments.
abstract: OBJECTIVE
  To review the gross, microscopic, and functional anatomy of the cranial cruciate ligament (CCL) in dogs.
  
  
  METHODS
  Literature review.
  
  
  METHODS
  Reports of the anatomy and function of the cruciate ligaments in dogs were retrieved by search of the 1975-2005 PubMed database.
  
  
  RESULTS
  The CCL has an important biomechanical function resisting cranial drawer, hyperextension, and internal rotation and acts to fine tune and guide the stifle through its rolling and sliding motion. It has a complex architecture, and distinct geographic regions within the ligament have different functional roles depending on the angle and loading conditions. Collagen type I is the main component of the extracellular matrix; the fibrils have a crimped structure. The cruciate ligaments are almost completely covered by synovium, protecting them from synovial fluid. Cruciate blood supply is mainly of soft tissue origin. The intraligamentous network is relatively limited whereas the core of the middle third of the CCL is even less well vascularized. Neurohistologic studies are very limited in the dog. Various mechanoreceptors and proprioceptive receptors have been identified within the substance of the cruciate ligaments.
  
  
  CONCLUSIONS
  CCL structural characteristics play an important part in its complex behaviour with the crimped pattern of the collagen fibrils being an important determinant of its biomechanical properties. In contrast to reports of managing CCL rupture, there are few reports describing the microanatomy and neurovascular morphology of the cruciate ligaments.
  
  
  CONCLUSIONS
  Cruciate disease is likely multi-factorial. Improved understanding of CCL degradation leading to CCL rupture is critical to development of new diagnostic tests for cruciate disease in dogs. Appropriate intervention during the early stages of disease process might preserve CCL structural properties by preventing further collagen degradation. Accurate knowledge of functional and fiber bundle anatomy is imperative for reconstruction and restoration of normal stifle joint physiology. Reconstructive goals should alleviate existing instability and mimic normal kinematics. Knowledge of the exact function of the CCL in the neuromuscular control around the stifle joint could possibly explain osteoarthritis progression after CCL damage.
authors.affiliation: Departments of Small Animal Medicine and Clinical Biology, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium. hilde.derooster@Ugent.be
authors.forename: Hilde
authors.initials: H
authors.lastname: de Rooster
authors.forename: Tanya
authors.initials: T
authors.lastname: de Bruin
authors.forename: Henri
authors.initials: H
authors.lastname: van Bree
mesh_terms: D000818:Animals; D016118:Anterior Cruciate Ligament / Q000033:anatomy & histology* / Q000502:physiology* / Q000648:ultrastructure; D001696:Biomechanical Phenomena; D003094:Collagen / Q000378:metabolism; D004283:Dog Diseases / Q000473:pathology; D004285:Dogs / Q000033:anatomy & histology* / Q000502:physiology*; D007592:Joint Diseases / Q000473:pathology / Q000662:veterinary; D012422:Rupture, Spontaneous / Q000662:veterinary; D013582:Synovial Fluid / Q000378:metabolism
chemical_list: D003094:Collagen