Pyrimidine as constituent of natural biologically active compounds.
This review describes the various manifestations of the pyrimidine system (alkylated, glycosylated, benzo-annelated.). These comprise pyrimidine nucleosides as well as alkaloids and antibiotics--some of them have been discovered and isolated from natural sources already long time ago, others have been reported very recently. A short overview on pyrimidine syntheses (prebiotic synthesis, biosynthesis, and metabolism) is given. The biological activities of most of the pyrimidine analogs are briefly described, and, in some cases, syntheses are formulated.
Lagoja
Irene M
IM
Laboratory of Medicinal Chemistry, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, B-3000 Leuven. irene.lagoja@rega.kuleuven.ac.be
D001688:Biological Products / Q000737:chemistry*; D011743:Pyrimidines / Q000737:chemistry* / Q000378:metabolism
D001688:Biological Products; D011743:Pyrimidines