Should we discard the renal allografts from cardiac death donors that have total ischemic time longer than 24 hours?
OBJECTIVE
The objective of this study was to investigate the outcome of transplantation using kidney grafts donated after cardiac death (DCD) with a total ischemic time (TIT) longer than 24 hours.


METHODS
We followed 373 kidneys recovered from DCD donors and transplanted at 41 centers. All kidneys were procured from uncontrolled DCD donors. Grafts were classified into two groups according to TIT. We recorded renal function and duration of the survival period for each graft.


RESULTS
Fifty-three grafts had a TIT longer than 24 hours (group 1). The other 320 grafts had a TIT less than 24 hours (group 2). The number of never functioning grafts were three in group 1 (5.7%) and 17 in group 2 (5.3%). Delayed graft function (DGF) occurred in 44 group 1 (83.0%) and 254 group 2 kidneys (79.4%) for intervals of 13.5 +/- 12.6 versus 10.9 +/- 12.6 days, respectively. Graft survival rates at 3, 5, and 10 years posttransplant were 84.9%, 73.0%, 64.1% for group 1, and 76.3%, 69.9%, 57.1% for group 2. In a Cox proportional hazards model, TIT longer than 24 hours was not a significant independent risk factor.


CONCLUSIONS
Our results showed that even kidneys with TITs of over 24 hours yielded comparable results despite a higher incidence of DGF.
Hayakawa
K
K
Department of Urology, Fujita Health University, Toyoake, Aichi, Japan.
Kubota
Y
Y
Sasaki
H
H
Kusaka
M
M
Maruyama
T
T
Shiroki
R
R
Hoshinaga
K
K
D016757:Death, Sudden, Cardiac; D005500:Follow-Up Studies; D006085:Graft Survival; D006801:Humans; D007511:Ischemia / Q000401:mortality*; D007668:Kidney; D016030:Kidney Transplantation / Q000502:physiology*; D018579:Patient Selection; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D012307:Risk Factors; D013997:Time Factors; D014019:Tissue Donors / Q000706:statistics & numerical data*; D016896:Treatment Outcome