Phospholipid scramblase 1.
Phospholipid scramblase 1 (PLSCR1) is a calcium-binding, multiply palmitoylated type II endofacial plasma membrane protein, while unpalmitoylated PLSCR1 protein can import into the nucleus, where it binds to genomic DNA. Although the original work showed that PLSCR1 contributes to the transbilayer movement of phospholipids, the following studies revealed that PLSCR1 expression can be induced by some cytokines such as interferon, epidermal growth factor, and also by leukemic cell differentiation-inducing agents such as all-trans retinoic acid (ATRA) and phorbol 12-myristate 13-acetate (PMA). PLSCR1 was also shown to interact with several protein kinases including c-Abl, c-Src, protein kinase Cdelta as well as some other proteins such as onzin, suggesting the roles of PLSCR1 in cell signaling. Indeed, the current evidence proposes that PLSCR1 contributes to cell proliferation, differentiation, apoptosis, and plays roles in the pathogenesis of cancers, especially leukemia.
Huang
Ying
Y
Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Ministry of Education of China, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China.
Zhao
Qian
Q
Chen
Guo-Qiang
GQ
D017209:Apoptosis; D002454:Cell Differentiation; D049109:Cell Proliferation; D016207:Cytokines / Q000378:metabolism; D006801:Humans; D007938:Leukemia / Q000473:pathology; D049294:Phospholipid Transfer Proteins / Q000502:physiology*; D010743:Phospholipids / Q000378:metabolism; D011494:Protein Kinases / Q000378:metabolism
D016207:Cytokines; C493422:PLSCR1 protein, human; D049294:Phospholipid Transfer Proteins; D010743:Phospholipids; D011494:Protein Kinases