title: In vitro activities of cloxyquin (5-chloroquinolin-8-ol) against Mycobacterium tuberculosis.
abstract: The in vitro activities of cloxyquin (5-chloroquinolin-8-ol) against 9 standard strains and 150 clinical isolates of Mycobacterium tuberculosis were studied. The MICs ranged from 0.062 to 0.25 microg/ml. The MIC(50) and MIC(90) were 0.125 and 0.25 microg/ml, respectively. These indicate that cloxyquin exhibited good antituberculosis activity, even for multidrug-resistant isolates.
authors.affiliation: Division of Microbiology, Department of Pathology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Rama VI Road, Bangkok 10400, Thailand. Poonpilas@hotmail.com
authors.forename: Poonpilas
authors.initials: P
authors.lastname: Hongmanee
authors.forename: Kamolchanok
authors.initials: K
authors.lastname: Rukseree
authors.forename: Benjamas
authors.initials: B
authors.lastname: Buabut
authors.forename: Boontiwa
authors.initials: B
authors.lastname: Somsri
authors.forename: Prasit
authors.initials: P
authors.lastname: Palittapongarnpim
mesh_terms: D000995:Antitubercular Agents / Q000494:pharmacology*; D002739:Chloroquinolinols / Q000494:pharmacology*; D024901:Drug Resistance, Multiple, Bacterial; D006801:Humans; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D013329:Structure-Activity Relationship; D014397:Tuberculosis, Pulmonary / Q000382:microbiology
chemical_list: D000995:Antitubercular Agents; D002739:Chloroquinolinols; C519493:cloxyquin