Immune activation and normal levels of endogenous antivirals are seen in healthy adolescents born of HIV-infected mothers.
Immunological analyses performed in healthy adolescents born of HIV-infected (seroreverters) or healthy mothers (healthy controls; HC) showed that immune activation and a skewing of postthymic differentiation are present in adolescent seroreverters. In-utero HIV exposure results in long-lasting imprinting on the immune system. Alternatively, an immune response naturally more prone to activation could prevent vertical infection. Endogenous antivirals (APOBEC, TRIM5alpha) were comparable in seroreverters and HC, and might not play a role in resistance to vertical HIV infection.
Vigano
Alessandra
A
Department of Pediatrics, Luigi Sacco Hospital, Milan, Italy.
Saresella
Marina
M
Schenal
Monica
M
Erba
Paola
P
Piacentini
Luca
L
Tornaghi
Raffaella
R
Naddeo
Valentina
V
Giacomet
Vania
V
Borelli
Manuela
M
Trabattoni
Daria
D
Clerici
Mario
M
D000293:Adolescent; D000328:Adult; D002648:Child; D005260:Female; D015658:HIV Infections / Q000276:immunology / Q000635:transmission; D018023:HIV Seronegativity / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular; D018445:Infectious Disease Transmission, Vertical; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious; D011297:Prenatal Exposure Delayed Effects