title: Nanostructured biomaterials for tissue engineering bone.
abstract: Advances in several critical research fields (processing, catalytic, optical, actuation, electrical, mechanical, etc.) have started to benefit from nanotechnology. Nano-technology can be broadly defined as the use of materials and systems whose structures and components exhibit novel and significantly changed properties when control is gained at the atomic, molecular, and supramolecular levels. Specifically, such advances have been found for materials when particulate size is decreased to below 100 nm. However, to date, relatively few advantages have been described for biological applications (specifically, those involving bone tissue engineering). This chapter elucidates several promising examples of how nanophase materials can be used to improve orthopedic implant applications. These include mechanical advantages as well as altered cell functions, leading to increased bone tissue regeneration on a wide range of nanophase materials including ceramics, polymers, metals, and composites thereof. Such advances were previously unimaginable with conventional materials possessing large micron-sized particulates.
authors.affiliation: Division of Engineering and Orthopaedics, Brown University, Providence, RI 02912, USA. Thomas_Webster@Brown.edu
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Webster
authors.forename: Edward S
authors.initials: ES
authors.lastname: Ahn
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D018786:Bone Substitutes; D001842:Bone and Bones / Q000166:cytology* / Q000502:physiology*; D018929:Cell Culture Techniques / Q000379:methods*; D006801:Humans; D049329:Nanostructures / Q000737:chemistry*; D023822:Tissue Engineering / Q000379:methods*
chemical_list: D001672:Biocompatible Materials; D018786:Bone Substitutes