[Evaluation of residual immune response against human pox virus before and after revaccination in healthy volunteers].
Although the risk of smallpox virus being used as a terrorist weapon is very low, it is mandatory to examine potential vaccination strategies, and also the residual immunization rate in the general population. During revaccination of a national intervention team, the residual immunity of 184 volunteers was determined by assaying T memory cells in the gamma interferon ELISpot test, and central T memory cell responses in a proliferation assay. Three-quarters of the subjects had a proliferative response. This response was lower after the age of 55 years but could be reactivated by revaccination.
Bricaire
François
F
Service des Maladies Infectieuses et Tropicales, G.H. Pitié-Salpêtrière, 47-83 Boulevard de l'Hôpital, 75013 Paris.
Combadière
Behazine
B
Rouleau
Etienne
E
Bossi
Philippe
P
Garin
Daniel
D
Lebrun-Vignes
Bénédicte
B
Autran
Brigitte
B
D000328:Adult; D000368:Aged; D023482:Bioterrorism; D004196:Disease Outbreaks / Q000517:prevention & control*; D005260:Female; D006801:Humans; D007117:Immunization, Secondary; D007156:Immunologic Memory; D008297:Male; D008875:Middle Aged; D012899:Smallpox / Q000517:prevention & control*; D012900:Smallpox Vaccine / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology; D014611:Vaccination; D014615:Vaccinia / Q000276:immunology*; D012901:Variola virus / Q000276:immunology*
D012900:Smallpox Vaccine