title: The prophylactic effectiveness of various antifungal agents against the progression of trichosporonosis fungemia to disseminated disease in a neutropenic mouse model.
abstract: Neutropenic mice with latent trichosporonemia were given various antifungal agents (amphotericin B, fluconazole, itraconazole) or saline to determine which antifungal agent could be useful for prophylaxis. The 3-week-survival rate was 80% in the fluconazole group, 50% in the amphotericin B group, 45% in the itraconazole group, and 30% in the saline group. Compared with the other antifungal agents, fluconazole offered superior prophylaxis against the progression of trichosporonosis fungemia to disseminated disease (P<0.05). These results suggest that clinical studies are warranted to investigate fluconazole prophylaxis of trichosporonosis progression in neutropenic patients, such as people receiving chemotherapy and patients who have received solid organ transplants.
authors.affiliation: Department of Infectious Diseases, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-machi, Yufu, Oita 879-5593, Japan. issei@med.oita-u.ac.jp
authors.forename: Issei
authors.initials: I
authors.lastname: Tokimatsu
authors.forename: Hisako
authors.initials: H
authors.lastname: Kushima
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Hashinaga
authors.forename: Kenji
authors.initials: K
authors.lastname: Umeki
authors.forename: Minoru
authors.initials: M
authors.lastname: Ohama
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ishii
authors.forename: Kenji
authors.initials: K
authors.lastname: Kishi
authors.forename: Kazufumi
authors.initials: K
authors.lastname: Hiramatsu
authors.forename: Jun-Ichi
authors.initials: J
authors.lastname: Kadota
mesh_terms: D000666:Amphotericin B / Q000494:pharmacology / Q000627:therapeutic use; D000825:Animal Structures / Q000473:pathology; D000818:Animals; D019072:Antibiotic Prophylaxis; D000935:Antifungal Agents / Q000494:pharmacology / Q000627:therapeutic use*; D003520:Cyclophosphamide / Q000494:pharmacology; D004195:Disease Models, Animal; D015725:Fluconazole / Q000494:pharmacology / Q000627:therapeutic use; D016469:Fungemia / Q000150:complications / Q000188:drug therapy* / Q000382:microbiology; D017964:Itraconazole / Q000494:pharmacology / Q000627:therapeutic use; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D008826:Microbial Sensitivity Tests; D009503:Neutropenia / Q000139:chemically induced / Q000150:complications*; D016019:Survival Analysis; D016896:Treatment Outcome; D014250:Trichosporon / Q000187:drug effects*
chemical_list: D000935:Antifungal Agents; D017964:Itraconazole; D000666:Amphotericin B; D003520:Cyclophosphamide; D015725:Fluconazole