Cytotoxic ent-kaurane diterpenoids from Isodon eriocalyx.
Five new ent-kaurane diterpenoids, epi-maoecrystal N (1), eriocalyxin G (2), maoecrystal W (3), maoecrystal X (4), and maoecrystal Y (5), along with 22 known ones, were isolated from Isodon eriocalyx (Dunn.) Hara., and their structures were determined by spectroscopic methods. All diterpenoids, except for 3 and 13, were evaluated for inhibition of the K562, T-24, Me180, QGY-7701, and BIU87 cell lines (Table 2).
Shen
Yun-Heng
YH
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, PR China.
Wen
Zhi-Ying
ZY
Xu
Gang
G
Xiao
Wei-Lie
WL
Peng
Li-Yan
LY
Lin
Zhong-Wen
ZW
Sun
Han-Dong
HD
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D003603:Cytotoxins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D045786:Diterpenes, Kaurane / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D037602:Isodon; D020014:K562 Cells; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018515:Plant Leaves
D000972:Antineoplastic Agents, Phytogenic; D003603:Cytotoxins; D004224:Diterpenes; D045786:Diterpenes, Kaurane; D010936:Plant Extracts