In vitro acetylcholinesterase inhibitory properties of thymol, carvacrol and their derivatives thymoquinone and thymohydroquinone.
The aim of this study was to examine in vitro the inhibitory activity exerted by the main constituents of essential oil obtained from the aromatic plant Thymus vulgaris L. on acetylcholinesterase (AChE). The total essential oil and selected compounds, specifically linalool and thymol, carvacrol and their derivatives thymoquinone and thymohydroquinone, were tested for AChE inhibition. Thymohydroquinone exhibited the strongest AChE inhibitory effect over the range of concentrations. The AChE inhibitory potential decreased in the following order: thymohydroquinone > carvacrol > thymoquinone > essential oil > thymol > linalool. It is interesting that the AChE inhibitory effect exerted by carvacrol was 10 times stronger than that exerted by its isomer thymol, although thymol and carvacrol have a very similar structure.
Jukic
Mila
M
Faculty of Chemistry and Technology, Department of Biochemistry, University of Split, Teslina 10/V, 21000 Split, Croatia. mila@ktf-split.hr
Politeo
Olivera
O
Maksimovic
Milka
M
Milos
Mia
M
Milos
Mladen
M
D000110:Acetylcholinesterase / Q000187:drug effects*; D000544:Alzheimer Disease / Q000188:drug therapy; D016227:Benzoquinones / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D000081007:Cymenes; D004305:Dose-Response Relationship, Drug; D004791:Enzyme Inhibitors / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D039821:Monoterpenes / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D008517:Phytotherapy; D010938:Plant Oils / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D013943:Thymol / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000494:pharmacology / Q000627:therapeutic use; D046930:Thymus Plant
D016227:Benzoquinones; D000081007:Cymenes; D004791:Enzyme Inhibitors; D039821:Monoterpenes; D010938:Plant Oils; C003465:thymohydroquinone; D013943:Thymol; C073316:carvacrol; D000110:Acetylcholinesterase; C003466:thymoquinone