title: The possible influence of L-histidine on the origin of the first peptides on the primordial Earth.
abstract: One of the most unsettled problems of prebiotic evolution and the origin of life is the explanation why one enantiomeric form of biomolecules prevailed. In the experiments presented in this paper, the influence of L-histidine on the peptide formation in the Salt-Induced Peptide Formation (SIPF) reaction of the enantiomeric forms of valine, proline, serine, lysine, and tryptophan, and the catalytic effects in this first step toward the first building blocks of proteins on the primordial earth were investigated. In the majority of the produced dipeptides, a remarkable increase of yields was shown, and the preference of the L-amino acids in the peptide formation in most cases cannot be denied. In summary, our data provide further experimental evidence for the plausibility of the SIPF reaction and point at a possible important role of L-histidine in the chemical evolution on the primordial Earth.
authors.affiliation: Division of Theoretical Chemistry, Institute of General, Inorganic and Theoretical Chemistry, University of Innsbruck, Innrain 52a, A-6020 Innsbruck.
authors.forename: Hannes
authors.initials: H
authors.lastname: Reiner
authors.forename: Kristof
authors.initials: K
authors.lastname: Plankensteiner
authors.forename: Daniel
authors.initials: D
authors.lastname: Fitz
authors.forename: Bernd Michael
authors.initials: BM
authors.lastname: Rode
mesh_terms: D002384:Catalysis; D019295:Computational Biology; D018534:Earth, Planet; D019418:Evolution, Chemical; D006639:Histidine / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D010455:Peptides / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D010455:Peptides; D006639:Histidine