Gene expression profile of abdominal aortic aneurysm rupture.
To search for novel transcriptional pathways that are activated in abdominal aortic aneurysm rupture, cDNA microarrays were used to compare global mRNA expression at the aneurysm rupture edge to anterior sac, and selected results were confirmed using quantitative real-time-polymerase chain reaction (QRT-PCR). This study identified apoptosis, angiogenesis, and inflammation as potentially important participants during the process of aneurysm rupture.
Choke
Edward
E
Department of Cardiovascular Sciences, Academic Vascular Surgery Unit, St. George's, University of London, UK.
Thompson
Matthew M
MM
Jones
Alun
A
Torsney
Evelyn
E
Dawson
Joseph
J
Laing
Kenneth
K
Nasr
Hosaam
H
Loftus
Ian M
IM
Cockerill
Gillian W
GW
D017544:Aortic Aneurysm, Abdominal / Q000235:genetics*; D001019:Aortic Rupture / Q000235:genetics*; D015870:Gene Expression; D020869:Gene Expression Profiling; D006801:Humans; D020411:Oligonucleotide Array Sequence Analysis; D012333:RNA, Messenger / Q000235:genetics
D012333:RNA, Messenger