title: Usefulness of serum pepsinogens in Helicobacter pylori chronic gastritis: relationship with inflammation, activity, and density of the bacterium.
abstract: We sought to study the relationship between serum pepsinogens and different histopathologic features of Helicobacter pylori-related chronic gastritis. One hundred forty-nine consecutive dyspeptic patients underwent endoscopy with biopsies; serum pepsinogens I and II were measured by immunoassay. Serum levels of pepsinogens (sPG) were significantly correlated with H. pylori density both of the corpus (sPGI: r = 0.32, P < .001; sPGII: r = 0.56, P < .001) and antrum (sPGI: r = 0.41, P < .001; sPGII: r = 0.43, P < .001) as well as with chronic inflammation (sPGI: r = 0.26, P < .001; sPGII: r = 0.49, P < .001) and activity (sPGI: r = 0.38, P < .001; sPGII: r = 0.50, P < .001) in the antrum. Only sPGII was correlated with chronic inflammation (r = 0.44, P < .001) and activity (r = 0.40, P < .001) in the corpus. SPGI was inversely correlated with atrophy (r = -0.33, P < .001) and intestinal metaplasia (r = -0.37, P < .001) in the corpus. sPGII levels could be considered as markers of gastric inflammation all over in the stomach. sPGI levels are inversely related to atrophic body gastritis.
authors.affiliation: Chair of Gastroenterology, Department of Clinical Sciences, University of Parma, Via Gramsci 14, 43100 Parma, Italy. francesco.dimario@unipr.it
authors.forename: Francesco
authors.initials: F
authors.lastname: Di Mario
authors.forename: Lucas Giovanni
authors.initials: LG
authors.lastname: Cavallaro
authors.forename: Ali Mahamat
authors.initials: AM
authors.lastname: Moussa
authors.forename: Pietro
authors.initials: P
authors.lastname: Caruana
authors.forename: Roberta
authors.initials: R
authors.lastname: Merli
authors.forename: Andrea
authors.initials: A
authors.lastname: Maini
authors.forename: Simone
authors.initials: S
authors.lastname: Bertolini
authors.forename: Nadia
authors.initials: N
authors.lastname: Dal Bó
authors.forename: Massimo
authors.initials: M
authors.lastname: Rugge
authors.forename: Giulia Martina
authors.initials: GM
authors.lastname: Cavestro
authors.forename: Giovanni
authors.initials: G
authors.lastname: Aragona
authors.forename: Mario
authors.initials: M
authors.lastname: Plebani
authors.forename: Angelo
authors.initials: A
authors.lastname: Franzé
authors.forename: Giorgio
authors.initials: G
authors.lastname: Nervi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D002908:Chronic Disease; D005260:Female; D005756:Gastritis / Q000097:blood* / Q000382:microbiology* / Q000473:pathology; D016481:Helicobacter Infections / Q000097:blood* / Q000473:pathology; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D008875:Middle Aged; D020116:Pepsinogen A / Q000097:blood*; D020115:Pepsinogen C / Q000097:blood*; D012720:Severity of Illness Index
chemical_list: D020115:Pepsinogen C; D020116:Pepsinogen A