Sensitivity of rabies virus to type I interferon is determined by the phosphoprotein gene.
The growth of a virulent strain of fixed rabies virus, Nishigahara, in mouse neuroblastoma NA cells treated with type I interferon (IFN) was compared with that of a derivative avirulent strain, Ni-CE. Nishigahara strain was slightly sensitive to IFN treatment but still grew more efficiently than did Ni-CE strain in IFN-treated NA cells. Furthermore, a virulent chimeric virus with the phosphoprotein gene from Nishigahara strain in the Ni-CE genome was less sensitive to IFN treatment than was Ni-CE strain, indicating that the IFN sensitivity is determined by the phosphoprotein gene of the virus.
Shimizu
Kenta
K
The United Graduate School of Veterinary Sciences, Faculty of Applied Biological Sciences, Gifu University, Gifu, Japan.
Ito
Naoto
N
Sugiyama
Makoto
M
Minamoto
Nobuyuki
N
D000818:Animals; D024882:Drug Resistance, Viral / Q000502:physiology*; D007370:Interferon Type I / Q000494:pharmacology*; D051379:Mice; D018832:Molecular Chaperones; D010750:Phosphoproteins / Q000235:genetics / Q000502:physiology*; D011818:Rabies / Q000821:virology*; D011820:Rabies virus / Q000187:drug effects* / Q000235:genetics / Q000472:pathogenicity; D015678:Viral Structural Proteins / Q000235:genetics / Q000502:physiology*; D014774:Virulence / Q000235:genetics
D007370:Interferon Type I; D018832:Molecular Chaperones; C103961:P phosphoprotein, Rabies virus; D010750:Phosphoproteins; D015678:Viral Structural Proteins