title: A simple NMR analysis of the protonation equilibrium that accompanies aminoglycoside recognition: dramatic alterations in the neomycin-B protonation state upon binding to a 23-mer RNA aptamer.
abstract: A complete characterisation of the protonation equilibrium that accompanies the molecular recognition of neomycin-B by a specific RNA receptor has been achieved by employing simple NMR measurements.
authors.affiliation: Instituto de Química Orgánica General (CSIC), c/Juan de la Cierva 3, Madrid, Spain.
authors.forename: Felix
authors.initials: F
authors.lastname: Freire
authors.forename: Igor
authors.initials: I
authors.lastname: Cuesta
authors.forename: Francisco
authors.initials: F
authors.lastname: Corzana
authors.forename: Julia
authors.initials: J
authors.lastname: Revuelta
authors.forename: Carlos
authors.initials: C
authors.lastname: González
authors.forename: Milos
authors.initials: M
authors.lastname: Hricovini
authors.forename: Agatha
authors.initials: A
authors.lastname: Bastida
authors.forename: Jesús
authors.initials: J
authors.lastname: Jiménez-Barbero
authors.forename: Juan Luis
authors.initials: JL
authors.lastname: Asensio
mesh_terms: D000617:Aminoglycosides / Q000737:chemistry*; D000838:Anions / Q000737:chemistry; D052157:Aptamers, Nucleotide / Q000737:chemistry*; D001483:Base Sequence; D001665:Binding Sites; D005601:Framycetin / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D011522:Protons; D017186:Titrimetry
chemical_list: D000617:Aminoglycosides; D000838:Anions; D052157:Aptamers, Nucleotide; D011522:Protons; D005601:Framycetin