title: fMRI bold signal analysis using a novel nonparametric statistical method.
abstract: We present in this article a novel analytical method that enables the application of nonparametric rank-order statistics to fMRI data analysis, since it takes the omnipresent serial correlations (temporal autocorrelations) properly into account. Comparative simulations, using the common General Linear Model and the permutation test, confirm the validity and usefulness of our approach. Our simulations, which are performed with both synthetic and real fMRI data, show that our method requires significantly less computation time than permutation-based methods, while offering the same order of robustness and returning more information about the evoked response when combined with/compared to the results obtained with the common General Lineal Model approach.
authors.affiliation: K.U.Leuven, Laboratorium voor Neuro- en Psychofysiologie, Herestraat 49-bus 1021, B-3000 Leuven, Belgium. patrick.demaziere@med.kuleuven.be
authors.forename: Patrick A
authors.initials: PA
authors.lastname: De Mazière
authors.forename: Marc M
authors.initials: MM
authors.lastname: Van Hulle
mesh_terms: D000465:Algorithms; D000818:Animals; D001921:Brain / Q000502:physiology*; D001931:Brain Mapping / Q000379:methods*; D003198:Computer Simulation; D003627:Data Interpretation, Statistical; D005071:Evoked Potentials / Q000502:physiology*; D000882:Haplorhini; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008959:Models, Neurological; D015233:Models, Statistical