A fluorous, Pummerer cyclative-capture strategy for the synthesis of N-heterocycles.
A fluorous, cyclative-capture strategy based on a new Pummerer cyclization process allows rapid access to tagged, heterocyclic frameworks. Convenient modification of the fluorous, heterocyclic scaffolds by using a variety of approaches including Pd-catalyzed cross-couplings is possible. Traceless, reductive cleavage of the fluorous-phase tag or oxidative cleavage and further elaboration, completes a strategy for the high-throughput, fluorous-phase synthesis of a diverse range of N-heterocycles.
McAllister
Laura A
LA
Department of Chemistry, The Joseph Black Building, The University of Glasgow, Glasgow G12 8QQ, Scotland.
McCormick
Rosemary A
RA
James
Karen M
KM
Brand
Stephen
S
Willetts
Nigel
N
Procter
David J
DJ
D003500:Cyclization; D005459:Fluorides / Q000737:chemistry*; D006571:Heterocyclic Compounds / Q000138:chemical synthesis*; D015394:Molecular Structure
D006571:Heterocyclic Compounds; D005459:Fluorides