title: Possible applications of antibodies or their genes in cancer therapy.
abstract: In this review article the possible applications of anti-tumor-associated antigen (TAA) antibodies in the therapy of cancer have been summarized. First, recombinant monoclonal antibodies (MAbs) are increasingly being used as therapeutic agents, especially in combination with anti-cancer drugs. Second, conjugation of antibody therapy with toxins or radioisotopes offers more therapeutic approaches. Third, development of cytotoxic T-lymphocyte (CTL) or natural killer (NK)-cell populations with anti-TAA antibody activity may be important for the success of cancer immunotherapy because the downregulated HLA class I molecules and the non-ubiquitous expression of NK receptor ligands in tumor tissues constitute the major tumor escape mechanism facing tumor-specific CTL- and/or NK-cell-mediated responses. Finally, in cancer gene therapy, the strategies to target viral vectors carrying therapeutic genes to tumor tissues by modifying the tropisms with MAbs or their genes against TAAs are also very promising.
authors.affiliation: Department of Biochemistry, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka, 814-0180, Japan. kurokima@fukuoka-u.ac.jp
authors.forename: Masahide
authors.initials: M
authors.lastname: Kuroki
authors.forename: Jian
authors.initials: J
authors.lastname: Huang
authors.forename: Hirotomo
authors.initials: H
authors.lastname: Shibaguchi
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Tanaka
authors.forename: Jun
authors.initials: J
authors.lastname: Zhao
authors.forename: Naixiang
authors.initials: N
authors.lastname: Luo
authors.forename: Ken
authors.initials: K
authors.lastname: Hachimine
authors.forename: Tetsushi
authors.initials: T
authors.lastname: Kinugasa
authors.forename: Shin-Ichi
authors.initials: S
authors.lastname: Maekawa
authors.forename: Sotaro
authors.initials: S
authors.lastname: Enatsu
authors.forename: Wakako
authors.initials: W
authors.lastname: Hamanaka
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Fukami
authors.forename: Motomu
authors.initials: M
authors.lastname: Kuroki
mesh_terms: D000818:Animals; D000906:Antibodies / Q000235:genetics* / Q000276:immunology / Q000627:therapeutic use*; D000911:Antibodies, Monoclonal / Q000276:immunology / Q000627:therapeutic use; D000951:Antigens, Neoplasm / Q000276:immunology*; D006801:Humans; D007116:Immunization, Passive / Q000379:methods*; D009369:Neoplasms / Q000276:immunology* / Q000628:therapy*
chemical_list: D000906:Antibodies; D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm