title: Congenital CMV infection in symptomatic infants in Delhi and surrounding areas.
abstract: Many viral infections are associated with significant maternal and fetal consequences during pregnancy among which cytomegalovirus is one of the most important agent, globally. Both primary and recurrent infection due to this virus can result in fetal infection. Samples from Congenital Anoammaled babies are referred to NICD from Delhi based Government hospitals and surrounding areas for diagnosis of congenital infections like Toxoplasm, Rubella, CMV and Herpes. In the present study, accumulated data is presented for the most common teratogenic virus--Cytomegalovirus prevalence as a causative agent for congenital infection in New Born babies at Delhi and surrounding areas. 96 samples from symptomatic babies in the age group of few days to 6 months exhibiting different congenital anomalies, were reported between 1 st Jan 04 to 30 th April/05. All the blood samples were tested for the detection of CMV (IgM) antibodies using m-capture ELISA technique. 18(18.75%) samples from babies showed positive titres for CMV-IgM antibodies. None of the mothers of positive babies were found positive for CMV-IgM antibodies but all were serologically exposed to CMV virus previously as their serum samples were positive for CMV-IgG antibodies indicating primary infection in the past or reactivation/reinfection with a different strain of CMV in the early pregnancy.
authors.affiliation: Department of Microbiology, National Institute of Communicable Diseases, Directorate General of Health Services, 22 Shamnath Marg, Delhi, India. shashikhare@hotmail.com
authors.forename: Inderjeet
authors.initials: I
authors.lastname: Gandhoke
authors.forename: Ramesh
authors.initials: R
authors.lastname: Aggarwal
authors.forename: Shiv
authors.initials: S
authors.lastname: Lal
authors.forename: Shashi
authors.initials: S
authors.lastname: Khare
mesh_terms: D000013:Congenital Abnormalities / Q000821:virology*; D003587:Cytomegalovirus / Q000276:immunology; D003586:Cytomegalovirus Infections / Q000151:congenital* / Q000453:epidemiology* / Q000821:virology; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D007194:India / Q000453:epidemiology; D007223:Infant; D007231:Infant, Newborn; D049590:Postpartum Period / Q000097:blood / Q000276:immunology
chemical_list: D007074:Immunoglobulin G; D007075:Immunoglobulin M