Structure and cytotoxicity of a new lanostane-type triterpene glycoside from the sea cucumber Holothuria hilla.
A new triterpene glycoside, hillaside C (1), was isolated from the sea cucumber Holothuria hilla Lesson, which is found in the South China Sea, and its structure has been elucidated by spectral analysis (ESI-MS and NMR) and chemical transformations. Four known compounds, holothuria A, thymine, uracil, and cholesterol, were also obtained. Compound 1 exhibited significant cytotoxicity against eight human tumor cell lines (A-549, MCF-7, IA9, CAKI-1, PC-3, KB, KB-VIN, and HCT-8) with IC50 values in the range of 0.15-3.20 microg/ml.
Wu
Jun
J
Research Center for Marine Drugs, College of Pharmacy, Second Military Medical University, 325 Guo-He Road, Shanghai, 200433, P.R. China. wu919067@126.com
Yi
Yang-Hua
YH
Tang
Hai-Feng
HF
Zou
Zheng-Rong
ZR
Wu
Hou-Ming
HM
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D045744:Cell Line, Tumor; D002784:Cholesterol / Q000737:chemistry; D004354:Drug Screening Assays, Antitumor; D006027:Glycosides / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D008956:Models, Chemical; D012616:Sea Cucumbers; D021241:Spectrometry, Mass, Electrospray Ionization; D013941:Thymine / Q000737:chemistry; D014315:Triterpenes / Q000737:chemistry* / Q000494:pharmacology; D014498:Uracil / Q000737:chemistry
D000970:Antineoplastic Agents; D006027:Glycosides; D014315:Triterpenes; C517476:hillaside C; D014498:Uracil; D002784:Cholesterol; D013941:Thymine