title: [Progress in studies of glutathione S-transferase P1 and prostate cancer].
abstract: Prostate cancer ( PCa) is an important genitourinary malignancy with increasing morbidity and mortality. Glutathione S-transferase P1 ( GSTP1) , as a phrase- II enzyme, has an important role in the activation and detoxification of carcinogens. There is a close association between GSTP1 gene polymorphisms and the risk of Pca. GSTP1 CpG island hypermethylation can reliably distinguish Pca from benign prostatic hyperplasia( BPH) and promises to be an important molecular marker for the diagnosis of Pca. This paper summarizes the association of GSTP1 with the diagnosis and risk of Pca.
authors.affiliation: Department of Urology, First Hospital, Heilongiiang University of Traditional Chinese Medicine, Harbin, Heilongjiang 150040, China.
authors.forename: Gao-feng
authors.initials: GF
authors.lastname: Hou
authors.forename: Yong
authors.initials: Y
authors.lastname: Sui
authors.forename: Li-wen
authors.initials: LW
authors.lastname: An
mesh_terms: D051549:Glutathione S-Transferase pi / Q000235:genetics; D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000175:diagnosis / Q000209:etiology
chemical_list: C496556:GSTP1 protein, human; D051549:Glutathione S-Transferase pi