title: Synthesis and cytotoxic evaluation of a series of resveratrol derivatives.
abstract: A total of 17 resveratrol (=(E)-5-[2-(4-hydroxyphenyl)ethenyl]benzene-1,3-diol) derivatives were synthesized from resveratrol (RES) through a facile approach. Among them, 13 compounds, 2 and 6-17, were reported for the first time, while 1 and 3-5 had already been reported several years ago. The cytotoxic activities of these compounds were evaluated against human nasopharyngeal epidermoid tumor cell line KB, and compounds 1 and 8-11 showed strong anticancer activities in vitro, comparable with that of 5-fluorouracil, an anticancer drug. On the basis of the experimental data obtained, structure-activity relationships are discussed.
authors.affiliation: Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, P.R. China.
authors.forename: Ban-Feng
authors.initials: BF
authors.lastname: Ruan
authors.forename: Xian-Feng
authors.initials: XF
authors.lastname: Huang
authors.forename: Hui
authors.initials: H
authors.lastname: Ding
authors.forename: Chen
authors.initials: C
authors.lastname: Xu
authors.forename: Hui-Ming
authors.initials: HM
authors.lastname: Ge
authors.forename: Hai-Liang
authors.initials: HL
authors.lastname: Zhu
authors.forename: Ren-Xiang
authors.initials: RX
authors.lastname: Tan
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007624:KB Cells; D015394:Molecular Structure; D000077185:Resveratrol; D013237:Stereoisomerism; D013267:Stilbenes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D013267:Stilbenes; D000077185:Resveratrol