title: Increasing evidence for immune-mediated processes and new therapeutic approaches in abdominal aortic aneurysms--a review.
abstract: Animal models for abdominal aortic aneurysms (AAAs), immunogenetical and pathophysiological studies support the importance of immune-mediated processes in the pathogenesis of AAA disease. Neutrophils, natural killer (NK) cells, monocytes/macrophages, and proinflammatory cytokines are involved in the complex and dynamic tissue remodeling of the AAA vessel wall. Our group showed an increased prevalence of circulating interferon-gamma (IFN-gamma) producing CD28(-) T cells especially in smaller AAAs, thus supporting the concept of a T cell-mediated pathophysiology of AAAs, especially during the early development of AAAs. Further research should now assess the possible benefit of anti-inflammatory therapeutic approaches in AAA patients, especially with small AAAs.
authors.affiliation: Department of Internal Medicine, Clinical Division of General Internal Medicine, Innsbruck Medical University, Innsbruck, Austria.
authors.forename: Christina
authors.initials: C
authors.lastname: Duftner
authors.forename: Rüdiger
authors.initials: R
authors.lastname: Seiler
authors.forename: Christian
authors.initials: C
authors.lastname: Dejaco
authors.forename: Gustav
authors.initials: G
authors.lastname: Fraedrich
authors.forename: Michael
authors.initials: M
authors.lastname: Schirmer
mesh_terms: D000818:Animals; D000906:Antibodies / Q000276:immunology; D017544:Aortic Aneurysm, Abdominal / Q000235:genetics / Q000276:immunology* / Q000628:therapy*; D015415:Biomarkers / Q000097:blood; D015395:Histocompatibility Antigens Class I / Q000276:immunology; D006801:Humans; D007167:Immunotherapy; D018836:Inflammation Mediators / Q000097:blood
chemical_list: D000906:Antibodies; D015415:Biomarkers; D015395:Histocompatibility Antigens Class I; D018836:Inflammation Mediators