title: [Pulmonary scintigraphy in evaluating the efficiency of surfactant therapy in the complex treatment of patients with destructive pulmonary tuberculosis].
abstract: Functional impairments of the mucociliary system (MCS) are known to develop in destructive tuberculous inflammation in the lung tissue. The effect of surfactant agents and their production stimulants is to recover the ventilation and gas exchange functions of the lung. The radioaerosol technique that adequately characterizes the deposition of an inhaled agent in the bronchial tree and records the state of mucociliary clearance (MCC) and MCS in different portions of the lung by the rate of tracer washout is of the greatest information value for the evaluation of MCC in vivo. Its normal values are in rather wide ranges so the absolute values are of low informative value. By taking into account the variability in the tracer washout range in health, the authors used only the time course of relative changes in this parameter--before and after surfactant therapy. The capacities of pulmonary scintigraphy were employed to monitor the efficiency of treatment for tuberculosis. The percentage of the activities in the areas of the right and left lung individually and in combination was estimated, by constructing the tracer washout curve. The percentage of 60-minute tracer washout was borne in mind to determine the rate of MCC.
authors.forename: N V
authors.initials: NV
authors.lastname: Chernichenko
authors.forename: A T
authors.initials: AT
authors.lastname: Sigaev
authors.forename: O V
authors.initials: OV
authors.lastname: Lovacheva
authors.forename: V V
authors.initials: VV
authors.lastname: Erokhin
mesh_terms: D000280:Administration, Inhalation; D005500:Follow-Up Studies; D006801:Humans; D009079:Mucociliary Clearance / Q000187:drug effects; D011663:Pulmonary Surfactants / Q000008:administration & dosage / Q000627:therapeutic use*; D011877:Radionuclide Imaging; D012189:Retrospective Studies; D016896:Treatment Outcome; D014397:Tuberculosis, Pulmonary / Q000000981:diagnostic imaging* / Q000188:drug therapy* / Q000378:metabolism
chemical_list: D011663:Pulmonary Surfactants