Benzophenanthridine alkaloids from Zanthoxylum nitidum (Roxb.) DC, and their analgesic and anti-inflammatory activities.
Seven benzophenanthridine alkaloids, 1-7, were isolated from the roots of Zanthoxylum nitidum. Among them, two novel alkaloids, named (R)-8-[(R)-1-hydroxyethyl]dihydrochelerythrine (1) and 8-methoxynorchelerythrine (2), were structurally identified as new compounds on the basis of the spectroscopic analysis. Bioactivity evaluation showed that nitidine (3), dihydrochelerythrine (4), oxyavicine (5), 8-methoxychelerythrine (6), and 8-hydroxydihydrochelerythrine (7) exhibit comparable analgesic and anti-inflammatory effects as hydrocortisone.
Hu
Jiang
J
Department of Phytochemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, P.R. China.
Zhang
Wei-Dong
WD
Liu
Run-Hui
RH
Zhang
Chuan
C
Shen
Yun-Heng
YH
Li
Hui-Liang
HL
Liang
Ming-Jin
MJ
Xu
Xi-Ke
XK
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use; D053119:Benzophenanthridines / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use; D004487:Edema / Q000188:drug therapy; D008297:Male; D051379:Mice; D015394:Molecular Structure; D010146:Pain / Q000188:drug therapy; D018517:Plant Roots / Q000737:chemistry; D013329:Structure-Activity Relationship; D032106:Zanthoxylum / Q000737:chemistry*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D053119:Benzophenanthridines