title: Chemotherapy of leishmaniasis Part VI: synthesis and bioevaluation of some novel terpenyl S,N- and N,N-acetals.
abstract: Some novel terpene based oxoketene S,N-acetals 2(a-g) and N,N-acetals 3(a-c) have been synthesized from oxoketene dithioacetal 1. The compounds were screened for their in vivo antileishmanial activity. Some of the compounds showed 50-70% inhibition in the hamster model.
authors.affiliation: Division of Medicinal Chemistry, Central Drug Research Institute, Chatter Manzil, Lucknow 226001, Uttar Pradesh, India. shivajins@yahoo.co.in
authors.forename: S N
authors.initials: SN
authors.lastname: Suryawanshi
authors.forename: Susmita
authors.initials: S
authors.lastname: Pandey
authors.lastname: Rashmirathi
authors.forename: B A
authors.initials: BA
authors.lastname: Bhatt
authors.forename: Suman
authors.initials: S
authors.lastname: Gupta
mesh_terms: D000080:Acetals / Q000138:chemical synthesis / Q000627:therapeutic use*; D000818:Animals; D000981:Antiprotozoal Agents / Q000138:chemical synthesis / Q000627:therapeutic use*; D006224:Cricetinae; D004195:Disease Models, Animal; D007893:Leishmania donovani / Q000187:drug effects*; D007896:Leishmaniasis / Q000188:drug therapy*; D008297:Male; D015394:Molecular Structure; D021261:Parasitic Sensitivity Tests; D013729:Terpenes / Q000138:chemical synthesis / Q000627:therapeutic use*
chemical_list: D000080:Acetals; D000981:Antiprotozoal Agents; D013729:Terpenes