Primary synovial sarcoma in fallopian tube: case report and literature review.
Synovial sarcoma, a malignant mesenchymal neoplasm, occurs mostly near the joints of the extremities and occasionally outside the joint such as lung. We report a case of soft tissue sarcoma arising in the fallopian tube origin that showed characteristic pathological appearance of biphasic synovial sarcoma. Molecular analysis detected a fusion gene transcript of synovial sarcoma translocation (SYT) gene from chromosome 18 and synovial sarcoma X chromosome breakpoint 1 (SSX1) gene, which is believed to pathognomonic for synovial sarcoma of joint origin. Recurrent abdominal tumor, observed at 12 month after the initial surgery and following chemotherapy using doxorubicin, cisplatin and ifosfamide, partially responded to chemotherapy using paclitaxel and carboplatin and, then, optimal surgery was performed. This is the first report of a synovial sarcoma arising in the fallopian tube.
Mitsuhashi
Akira
A
Department of Reproductive Medicine, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan. makira-cib@umin.ac.jp
Nagai
Yuichiro
Y
Suzuka
Kiyomi
K
Yamazawa
Koji
K
Nojima
Takayuki
T
Nikaido
Takashi
T
Ishikura
Hiroshi
H
Matsui
Hideo
H
Shozu
Makio
M
D000328:Adult; D001483:Base Sequence; D005185:Fallopian Tube Neoplasms / Q000235:genetics / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D015514:Oncogene Proteins, Fusion / Q000235:genetics; D013584:Sarcoma, Synovial / Q000235:genetics / Q000473:pathology* / Q000601:surgery
D015514:Oncogene Proteins, Fusion; C116512:SYT-SSX fusion protein