title: Multicentre evaluation of performance of C-reactive protein analysis over a one-year period.
abstract: This communication deals with a longitudinal evaluation of C-reactive protein (CRP) analysis during a one-year period using a single lot of liquid control sera (3 levels) (BIOREF-CRP levels 1, 2 and 3) in different laboratories. A total of 652 sets of data were returned from 20 participating laboratories using 13 different reagent-measuring device combinations. The use of the control materials was defined in a standard operating procedure. Data was returned to the organizers on a monthly basis and questions could be asked or problems presented during the evaluation period. Although the performance of different reagents varied, the control materials were shown to be stable over the whole of the evaluation period when stored at 4-7 degrees C in a refrigerator/cold room. Typical problems were encountered, examples of which are presented here in graphical and tabular form.
authors.affiliation: BIOREF Biochemische Referenzmaterialien GmbH, Mömbris, Germany.
authors.forename: N
authors.initials: N
authors.lastname: Bewarder
authors.forename: F
authors.initials: F
authors.lastname: Abmeier
authors.forename: S
authors.initials: S
authors.lastname: Bergmann
authors.forename: S
authors.initials: S
authors.lastname: Drohla
authors.forename: V
authors.initials: V
authors.lastname: Drescher
authors.forename: A
authors.initials: A
authors.lastname: Gerstmeyer
authors.forename: S
authors.initials: S
authors.lastname: Kuss
authors.forename: L
authors.initials: L
authors.lastname: Melamies
authors.forename: R
authors.initials: R
authors.lastname: Miksch
authors.forename: V
authors.initials: V
authors.lastname: Ortin
authors.forename: A
authors.initials: A
authors.lastname: Rietschel-Klein
authors.forename: V
authors.initials: V
authors.lastname: Neumeister
authors.forename: J
authors.initials: J
authors.lastname: Odarjuk
authors.forename: M M
authors.initials: MM
authors.lastname: Stratmann
authors.forename: A
authors.initials: A
authors.lastname: Weinhold
authors.forename: B
authors.initials: B
authors.lastname: Wiesner
authors.forename: D A
authors.initials: DA
authors.lastname: Wildbredt
authors.forename: P
authors.initials: P
authors.lastname: Wollenberg
authors.forename: J
authors.initials: J
authors.lastname: Zinsmeyer
authors.forename: M
authors.initials: M
authors.lastname: Zogbaum
authors.forename: P
authors.initials: P
authors.lastname: Zwerenz
authors.forename: M
authors.initials: M
authors.lastname: Zwirner
authors.forename: W G
authors.initials: WG
authors.lastname: Wood
mesh_terms: D002097:C-Reactive Protein / Q000032:analysis*; D006801:Humans; D007202:Indicators and Reagents; D008137:Longitudinal Studies; D009391:Nephelometry and Turbidimetry / Q000379:methods; D015203:Reproducibility of Results
chemical_list: D007202:Indicators and Reagents; D002097:C-Reactive Protein