title: WY 14,643 inhibits human aldose reductase activity.
abstract: Aldose reductase (AR) is implicated to play a critical role in diabetes and cardiovascular complications because of the reaction it catalyzes. Our data reveal that peroxisome proliferator WY 14,643, follows a pure non-competitive inhibition pattern in the aldehyde reduction activity as well as in the alcohol oxidation activity of AR. This finding communicates for the first time a novel feature of WY 14,643 in regulating AR activity. In addition, this observation indicates that AR, AR-like proteins and aldo-keto reductase (AKR) members may be involved in the WY 14,643 mechanism of action when it is administered as PPAR agonist.
authors.affiliation: Division of Immunology, Beckman Research Institute and City of Hope National Medical Center, 1450 E. Duarte Road, Duarte, CA 91010, USA.
authors.forename: Sara
authors.initials: S
authors.lastname: Klemin
authors.forename: Richard Y
authors.initials: RY
authors.lastname: Calvo
authors.forename: Stephanie
authors.initials: S
authors.lastname: Bond
authors.forename: Heather
authors.initials: H
authors.lastname: Dingess
authors.forename: Balakrishnan
authors.initials: B
authors.lastname: Rajkumar
authors.forename: Rachel
authors.initials: R
authors.lastname: Perez
authors.forename: Lucy
authors.initials: L
authors.lastname: Chow
authors.forename: Ganesaratnam K
authors.initials: GK
authors.lastname: Balendiran
mesh_terms: D000449:Aldehyde Reductase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D019905:Benzyl Alcohol / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D015394:Molecular Structure; D010084:Oxidation-Reduction; D011743:Pyrimidines / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D004791:Enzyme Inhibitors; D011743:Pyrimidines; C006253:pirinixic acid; D000449:Aldehyde Reductase; D019905:Benzyl Alcohol