title: Tracing immature myelin in acute disseminated encephalomyelitis.
abstract: Inherent abnormalities of myelin have been suggested in the pathogenesis of multiple sclerosis (MS). We investigated myelin in acute disseminated encephalomyelitis (ADEM) patients by magnetic resonance spectroscopy (MRS) and cerebrospinal fluid (CSF) analysis for citrulline, a marker of immature myelin. A citrulline peak was observed in the normal appearing white matter of 7/15 patients and of 1/10 age-matched neurological controls (p=0.08). CSF citrulline was elevated in 4/6 patients. Alterations in the composition of myelin might predispose to or follow acute inflammatory disorders of the central nervous system.
authors.affiliation: Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey.
authors.forename: Banu
authors.initials: B
authors.lastname: Anlar
authors.forename: Kader
authors.initials: K
authors.lastname: Karli-Oğuz
authors.forename: Osman Yücel
authors.initials: OY
authors.lastname: Yurtyapan
authors.forename: Nesrin
authors.initials: N
authors.lastname: Senbil
authors.forename: Ozlem
authors.initials: O
authors.lastname: Hergüner
authors.forename: Sakir
authors.initials: S
authors.lastname: Altunbaşak
authors.forename: F Müjgan
authors.initials: FM
authors.lastname: Sönmez
authors.forename: Pinar
authors.initials: P
authors.lastname: Ozdemir-Geyik
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D002851:Chromatography, High Pressure Liquid; D002956:Citrulline / Q000378:metabolism*; D004673:Encephalomyelitis, Acute Disseminated / Q000134:cerebrospinal fluid / Q000378:metabolism*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D009186:Myelin Sheath / Q000378:metabolism*
chemical_list: D002956:Citrulline