A recurrent in-frame insertion in a CEBPA transactivation domain is a polymorphism rather than a mutation that does not affect gene expression profiling-based clustering of AML.
Wouters
Bas J
BJ
Louwers
Irene
I
Valk
Peter J M
PJ
Löwenberg
Bob
B
Delwel
Ruud
R
D000208:Acute Disease; D022762:CCAAT-Enhancer-Binding Proteins / Q000235:genetics* / Q000502:physiology; D016000:Cluster Analysis; D015331:Cohort Studies; D004252:DNA Mutational Analysis; D020440:Gene Duplication; D020869:Gene Expression Profiling; D006801:Humans; D007951:Leukemia, Myeloid / Q000453:epidemiology / Q000235:genetics*; D016254:Mutagenesis, Insertional; D011110:Polymorphism, Genetic; D017434:Protein Structure, Tertiary; D015533:Transcriptional Activation
D022762:CCAAT-Enhancer-Binding Proteins; C515848:CEBPA protein, human