title: Peculiarities of hemoglobin interaction with serum proteins of mice with Ehrlich carcinoma.
abstract: In male C57Bl/6 mice with transplanted Ehrlich carcinoma, hemoglobin forms a complex with serum proteins characterized by a molecular weight of about 300 kDa. The complex incorporates proteins weighing 100, 68, 65, and 15 kDa identified by MALDI-TOF mass spectrometry as haptoglobin, serum albumin, gi/26341396 nameless protein Mus musculus, and alpha-hemoglobin, respectively. This complex can possess biological activity and contribute to the control of tumor growth.
authors.affiliation: N. N. Blokhin Cancer Research Center, Russian Academy of Medical Sciences, Moscow.
authors.forename: S M
authors.initials: SM
authors.lastname: Sitdikova
authors.forename: B S
authors.initials: BS
authors.lastname: Amandzholov
authors.forename: M V
authors.initials: MV
authors.lastname: Serebryakova
authors.forename: M Yu
authors.initials: MY
authors.lastname: Zhdanovich
authors.forename: M V
authors.initials: MV
authors.lastname: Kiselevskii
authors.forename: F V
authors.initials: FV
authors.lastname: Donenko
mesh_terms: D000818:Animals; D001798:Blood Proteins / Q000378:metabolism*; D002286:Carcinoma, Ehrlich Tumor / Q000378:metabolism*; D002850:Chromatography, Gel; D002852:Chromatography, Ion Exchange; D004591:Electrophoresis, Polyacrylamide Gel; D006454:Hemoglobins / Q000378:metabolism*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D046912:Multiprotein Complexes / Q000096:biosynthesis*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
chemical_list: D001798:Blood Proteins; D006454:Hemoglobins; D046912:Multiprotein Complexes