title: [Comparison of two schemes of administering the Russian protamine sulfate after extracorporeal circulation in cardiosurgical patients].
abstract: The paper presents data of a study comparing two schemes (Scheme 1: a heparin/protamine ratio of 1:2; Scheme 2: a heparin/protamine ratio of 1:3) for administering protamine sulfate to neutralize heparin in patients after extracorporeal circulation. A larger dose of protamine sulfate is shown to induce significant thrombocytic dysfunction, resulting in increased postoperative hemorrhage. To minimize protamine sulfate doses required for neutralization of the anticoagulant effect of heparin is a way of preventing these complications.
authors.forename: M A
authors.initials: MA
authors.lastname: Charnaia
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Morozov
authors.forename: V G
authors.initials: VG
authors.lastname: Gladysheva
authors.forename: A M
authors.initials: AM
authors.lastname: Isaeva
mesh_terms: D001792:Blood Platelets / Q000187:drug effects; D001026:Coronary Artery Bypass; D005112:Extracorporeal Circulation; D006487:Hemostasis / Q000187:drug effects*; D006494:Heparin Antagonists / Q000008:administration & dosage* / Q000009:adverse effects; D006801:Humans; D011182:Postoperative Care; D011479:Protamines / Q000008:administration & dosage* / Q000009:adverse effects
chemical_list: D006494:Heparin Antagonists; D011479:Protamines