The stepping motor protein as a feedback control ratchet.
It is explained how going from a one headed motor protein to a stepping two headed motor protein is equivalent to going from a stochastically flashing ratchet to a feedback control ratchet. Both these ratchets have been well studied in the literature and their speeds and efficiencies are briefly reviewed. Next it is shown how a feedback control ratchet mechanism model can account for very accurate recent data obtained on kinesin. Finally, the role of internal friction in the operation of stepping motor proteins is discussed.
Bier
Martin
M
Department of Physics, East Carolina University, Greenville, NC 27858, USA. bierm@ecu.edu
D000818:Animals; D055592:Biophysical Phenomena; D001703:Biophysics; D005246:Feedback; D017276:Friction; D066298:In Vitro Techniques; D008954:Models, Biological; D020409:Molecular Motor Proteins / Q000502:physiology*; D009038:Motion; D009068:Movement; D013269:Stochastic Processes; D049490:Systems Biology
D020409:Molecular Motor Proteins