[Nebivolol effects on the cardiovascular system and the kidneys in pregnant and puerperal women with hypertension].
OBJECTIVE
To study nebivolol efficacy in pregnant and puerperal women with hypertension.


METHODS
Monitoring of endothelial function, central and peripheral hemodynamics (HD), myocardial function, intrarenal circulation and microalbuminuria (MAU) was performed in 90 pregnant (67 hypertensive and 23 normotensive) and 18 puerperal women who were diagnosed to have hypertension in pregnancy. The above parameters were estimated in 23 hypertensive gravidas and 18 puerperas treated with nebivolol.


RESULTS
Hypertensive gravidas had marked endothelial dysfunction (ED), impaired intrarenal HD, MAU, high total peripheral vascular resistance and left ventricular myocardial mass index (LVMMI). The puerperas with hypertension had ED, MAU, frequently HD disorders and a trend to a LVMMI rise. Nebivolol effectively reduced blood pressure, had a nephroprotective action, and improved HD and endothelial function.


CONCLUSIONS
Nebivolol (a highly selective beta 1-adrenoblocker) administration is effective pathogenetic treatment of pregnant and puerperal women with hypertension and may improve short- and long-term prognoses of such patients.
Tkacheva
O N
ON
Vertkin
A L
AL
Barabashkina
A V
AV
Vasil'eva
A V
AV
Razguliaeva
N F
NF
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology / Q000627:therapeutic use*; D000328:Adult; D000419:Albuminuria / Q000453:epidemiology; D001578:Benzopyrans / Q000494:pharmacology / Q000627:therapeutic use*; D004730:Endothelium, Vascular / Q000187:drug effects / Q000503:physiopathology; D004983:Ethanolamines / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000453:epidemiology* / Q000503:physiopathology; D007668:Kidney / Q000098:blood supply / Q000473:pathology; D009203:Myocardial Infarction / Q000188:drug therapy / Q000453:epidemiology / Q000503:physiopathology; D000068577:Nebivolol; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000188:drug therapy / Q000453:epidemiology* / Q000503:physiopathology; D011256:Pregnancy Outcome; D051436:Renal Insufficiency, Chronic / Q000453:epidemiology / Q000473:pathology
D000319:Adrenergic beta-Antagonists; D001578:Benzopyrans; D004983:Ethanolamines; D000068577:Nebivolol