title: Do psychological distress and somatization contribute to misattribution of asthma? A Chilean study.
abstract: OBJECTIVE
  The aim of this study was to assess the association between asthma and distress by whether symptoms of asthma present alone or are accompanied by atopy or bronchial reactivity to methacholine [bronchial responsiveness (BHR)], hence, to ascertain whether overreporting of asthma symptoms occurs in those with distress.
  
  
  METHODS
  We studied 601 young adults in four groups: those with asthma symptoms and atopy or positive BHR, those with asthma symptoms only, those with atopy or positive BHR only, and controls. The main independent variables were the General Health Questionnaire-12 (GHQ-12) and 45 physical symptoms to assess somatization.
  
  
  RESULTS
  The somatization score was highly associated with asthma symptoms alone and asthma symptoms with BHR or atopy, GHQ-12 with asthma alone and asthma and BHR or atopy related to a control group. After adjustment for somatization, GHQ-12 was not associated with the asthma outcomes.
  
  
  CONCLUSIONS
  Excess asthma symptom reporting due to psychological distress or somatization as a cause of the association is unlikely.
authors.affiliation: Division of Asthma, Allergy and Lung Biology, and Academic Department of Psychological Medicine, King's College London, London, United Kingdom. roberto.rona@iop.kcl.ac.uk
authors.forename: Roberto J
authors.initials: RJ
authors.lastname: Rona
authors.forename: Nigel C
authors.initials: NC
authors.lastname: Smeeton
authors.forename: Hugo
authors.initials: H
authors.lastname: Amigo
authors.forename: Claudio
authors.initials: C
authors.lastname: Vargas
mesh_terms: D000328:Adult; D001249:Asthma / Q000175:diagnosis / Q000523:psychology*; D016535:Bronchial Hyperreactivity / Q000523:psychology; D001985:Bronchial Provocation Tests; D005260:Female; D006801:Humans; D008297:Male; D012130:Respiratory Hypersensitivity / Q000175:diagnosis / Q000523:psychology; D012737:Sex Factors; D012803:Sick Role; D013001:Somatoform Disorders / Q000175:diagnosis / Q000523:psychology*; D013315:Stress, Psychological / Q000150:complications*; D011795:Surveys and Questionnaires