Microtubule capture: a concerted effort.
Kinetochores direct attachment of chromosomes to microtubules of the mitotic spindle during cell division. Three recent studies in Cell, including one in this issue, reveal important new roles for two kinetochore protein complexes-Ndc80 and INCENP-Survivin-in establishing the correct attachment of chromosomes to spindle microtubules (Cheeseman et al., 2006, DeLuca et al., 2006 and Sandall et al., 2006).
Kotwaliwale
Chitra
C
Fred Hutchinson Cancer Research Center, Division of Basic Sciences, 1100 Fairview Avenue North, A2-168, Seattle, WA 98109, USA.
Biggins
Sue
S
D000818:Animals; D064127:Aurora Kinases; D002453:Cell Cycle; D002868:Chromosomal Proteins, Non-Histone / Q000378:metabolism; D002875:Chromosomes / Q000737:chemistry / Q000378:metabolism*; D003598:Cytoskeletal Proteins / Q000378:metabolism; D006801:Humans; D018386:Kinetochores / Q000737:chemistry / Q000378:metabolism*; D008840:Microfilament Proteins / Q000378:metabolism; D008869:Microtubule-Associated Proteins / Q000378:metabolism*; D008870:Microtubules / Q000737:chemistry / Q000378:metabolism*; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism; D008941:Spindle Apparatus / Q000737:chemistry / Q000378:metabolism*
D002868:Chromosomal Proteins, Non-Histone; D003598:Cytoskeletal Proteins; C083767:INCENP protein, human; D008840:Microfilament Proteins; D008869:Microtubule-Associated Proteins; D064127:Aurora Kinases; D017346:Protein Serine-Threonine Kinases