title: Synthesis of novel 3-(alkylcarbamoyl)-2-aryl-1,2-dihydro-6,7-(methylenedioxy)-3H-quinazolin-4-ones as anticonvulsant agents.
abstract: A series of 3-(alkylcarbamoyl)-2-aryl-1,2-dihydro-6,7-(methylenedioxy)-3H-quinazolin-4-ones, compounds 3-6, were synthesized, and screened as anticonvulsant agents in DBA/2 mice against sound-induced seizure (Table). The new compounds were found to display anticonvulsant properties inferior to those of the known dehydro congeners 1 and 2. The binding affinities of 1-6 at the AMPA and NMDA receptors were also evaluated.
authors.affiliation: Dipartimento Farmaco-Chimico, Università degli Studi di Messina, Viale Annunziata, I-98168 Messina. nmicale@pharma.unime.it
authors.forename: Nicola
authors.initials: N
authors.lastname: Micale
authors.forename: Giovanna
authors.initials: G
authors.lastname: Postorino
authors.forename: Silvana
authors.initials: S
authors.lastname: Grasso
authors.forename: Maria
authors.initials: M
authors.lastname: Zappalà
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Zuccalà
authors.forename: Guido
authors.initials: G
authors.lastname: Ferreri
authors.forename: Giovambattista
authors.initials: G
authors.lastname: De Sarro
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis* / Q000378:metabolism / Q000627:therapeutic use; D015507:Drugs, Investigational / Q000138:chemical synthesis* / Q000378:metabolism / Q000627:therapeutic use; D051379:Mice; D008811:Mice, Inbred DBA; D011485:Protein Binding / Q000502:physiology; D011799:Quinazolines / Q000138:chemical synthesis* / Q000378:metabolism / Q000627:therapeutic use; D051381:Rats; D012640:Seizures / Q000517:prevention & control
chemical_list: D000927:Anticonvulsants; D015507:Drugs, Investigational; D011799:Quinazolines