title: [The analysis of plasma homocysteine among 1020 residents in community].
abstract: OBJECTIVE
  To study the plasma homocysteine (Hcy) distributive characteristics in different sex and age groups of the community residents in Guangdong, and to analyze its associated factors as well as its effects on cerebral artery stenosis.
  
  
  METHODS
  In this study, we presented data concerning 2500 residents who had undergone a systematic health checkup,including clinical and biologic examinations. Plasma was saved from 1020 residents who were asymptomatic but having TCD examination. Hcy concentration was measured by fluorescence ration biochemical assay kit.
  
  
  RESULTS
  The average plasma Hcy levels of males (15.0 micromol/L+/-5.8 micromol/L) were significantly higher than those of females (12.4 micromol/L-I 3.9 micromol/L, P< 0.05). Hcy level increased parallel with age. The prevalence rate of hyperhomocysteinemia in males (47.2%) was higher than in females (23.2%). Hcy levels in MCA stenosis group (18.3 micromol/L+ 5.3 micromol/L) were significantly higher than that in control group (12.9 micromol/L+/- 4.6 micromol/L, P< 0.05). Based on logistic regression analysis, Hcy was only associated with sex and age, but not with blood lipids etc.
  
  
  CONCLUSIONS
  Hcy levels were different in sex and age groups which emerged as independent predictors of hyperhomocysteinemia but had no association with blood lipids in the community residents, suggesting that hyperhomocysteinemia might worsen cerebral artery stenosis.
authors.affiliation: Department of Neurology, the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China.
authors.forename: Ming-hui
authors.initials: MH
authors.lastname: Guo
authors.forename: Jia-xing
authors.initials: JX
authors.lastname: Huang
authors.forename: Rui-jin
authors.initials: RJ
authors.lastname: Lin
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhang
authors.forename: Ya-li
authors.initials: YL
authors.lastname: Chen
mesh_terms: D002681:China / Q000453:epidemiology; D005260:Female; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D020138:Hyperhomocysteinemia / Q000453:epidemiology*; D008297:Male; D015995:Prevalence; D012016:Reference Values
chemical_list: D006710:Homocysteine