title: Ionic-liquid-supported synthesis: a novel liquid-phase strategy for organic synthesis.
abstract: Soluble ionic liquids have recently been used as supports for catalyst/reagent immobilization and synthesis in homogeneous solution phase. The wide range of ionic liquid supports available makes their use as supports compatible with most common chemistries. The solubility properties of these ionic liquid supports can be tuned by the variation of cations and anions to make them phase separate from less polar organic solvents and aqueous media. The ionic-liquid-supported species can therefore be purified from the reaction mixture by simple washings. Ionic-liquid-supported catalysts and reagents have been prepared and used, and they are easily recovered and reused. Parallel and combinatorial libraries of small molecules have been synthesized. Ionic-liquid-supported synthesis (ILSS) has been applied to the preparation of oligopeptides and oligosaccharides. The comparison of ILSS with solid-phase synthesis, soluble-polymer-supported synthesis, and fluorous phase synthesis has been highlighted where applicable.
authors.affiliation: Department of Chemistry, McGill University, Montreal, Quebec, Canada.
authors.forename: Weishi
authors.initials: W
authors.lastname: Miao
authors.forename: Tak Hang
authors.initials: TH
authors.lastname: Chan
mesh_terms: D002236:Carbohydrate Conformation; D002241:Carbohydrates / Q000138:chemical synthesis*; D002625:Chemistry, Organic / Q000379:methods*; D007477:Ions; D010455:Peptides / Q000138:chemical synthesis*; D011487:Protein Conformation
chemical_list: D002241:Carbohydrates; D007477:Ions; D010455:Peptides