title: [Effectiveness of allogeneic peripheral blood stem cell transplantation in 23 patients with myelodysplastic syndromes].
abstract: OBJECTIVE
  To analyse the outcome of allogeneic peripheral blood stem cell transplantation (allo-PBSCT) for myelodysplastic syndromes (MDS).
  
  
  METHODS
  Twenty-three patients with MDS received G-CSF mobilized HLA-identical sibling allo-PBSCT. The numbers of mononuclear cells (MNC) and CD34+ cells were 8. 25 (4.50 -22.36) x 10(8)/kg and 5.59 (1.57 - 12.22) x 10(6)/kg respectively. CsA and shorten course MTX were used for graft-versus-host disease (GVHD) prophylaxis and MMF was given on + 1 d - +28 d posttransplantation.
  
  
  RESULTS
  Among 23 patients, 22 achieved hematopoietic recovery. The median time of ANC > 1.0 x 10(9)/L and BPC > 50 x 10(9)/L were + 13 (+ 11 - +17) days and + 30 (+13 + 102) days respectively. Two patients died of transplant related complications and three died of disease relapse, while 18 patients survived. Kaplan-Meier analysis showed disease free survival and relapse rate were (77.8 +/- 8.7)% and (14.4 +/- 7.5)% respectively.
  
  
  CONCLUSIONS
  Allo-PBSCT is an effective treatment for MDS patients.
authors.affiliation: Hematopoietic Stem Cell Transplantation Center of PLA, Affiliated Hospital of Chinese Academy of Military Medical Sciences, Beijing, China.
authors.forename: Liang-ding
authors.initials: LD
authors.lastname: Hu
authors.forename: Hu
authors.initials: H
authors.lastname: Chen
authors.forename: Min
authors.initials: M
authors.lastname: Jiang
authors.forename: Bo-tao
authors.initials: BT
authors.lastname: Li
authors.forename: Mao-quan
authors.initials: MQ
authors.lastname: Qin
authors.forename: Zhi-yong
authors.initials: ZY
authors.lastname: Yu
authors.forename: Yu-hang
authors.initials: YH
authors.lastname: Li
mesh_terms: D000293:Adolescent; D000328:Adult; D018952:Antigens, CD34; D017707:Erythrocyte Transfusion; D005260:Female; D006085:Graft Survival; D006086:Graft vs Host Disease / Q000517:prevention & control; D006801:Humans; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000601:surgery*; D036102:Peripheral Blood Stem Cell Transplantation / Q000379:methods*; D014184:Transplantation, Homologous; D016896:Treatment Outcome
chemical_list: D018952:Antigens, CD34