title: Pathogenesis of thoracic and abdominal aortic aneurysms.
abstract: The major disease processes affecting the aorta are aortic aneurysms and dissections. Aneurysms are usually described in terms of their anatomic location, with thoracic aortic aneurysms (TAAs) involving the ascending and descending aorta in the thoracic cavity and abdominal aortic aneurysms (AAAs) involving the infrarenal abdominal aorta. Both thoracic and abdominal aortas are elastic arteries, and share similarities in their physical structures and cellular components. However, thoracic and abdominal aortas differ in their biochemical properties and the origin of their vascular smooth muscle cells (VSMCs). These similarities and differences between thoracic and abdominal aortas provide the basis for the various pathologic mechanisms observed in this disease. This review focuses on the comparison of the pathologic mechanisms involved in TAA and AAA.
authors.affiliation: Department of Internal Medicine, University of Texas Medical School, Houston, 6431 Fannin, MSB 6.039, Houston, TX 77030, USA. Dongchuan.Guo@uth.tmc.edu
authors.forename: Dong-Chuan
authors.initials: DC
authors.lastname: Guo
authors.forename: Christina L
authors.initials: CL
authors.lastname: Papke
authors.forename: Rumin
authors.initials: R
authors.lastname: He
authors.forename: Dianna M
authors.initials: DM
authors.lastname: Milewicz
mesh_terms: D000818:Animals; D017544:Aortic Aneurysm, Abdominal / Q000209:etiology* / Q000276:immunology / Q000473:pathology*; D017545:Aortic Aneurysm, Thoracic / Q000209:etiology* / Q000276:immunology / Q000473:pathology*; D050197:Atherosclerosis / Q000209:etiology / Q000473:pathology; D006801:Humans; D007249:Inflammation / Q000276:immunology