title: Preoperative analgesia with local lidocaine infiltration for abdominal hysterectomy pain management.
abstract: OBJECTIVE
  To evaluate the impact of preemptive local analgesia at the incision site in reducing pain in women undergoing abdominal hysterectomy for a benign myomatous uterus.
  
  
  METHODS
  In this prospective, randomized, double-blinded, placebo-controlled study, 20 mL of 1% lidocaine or 0.9% saline was injected at the abdominal incision site prior to the performance of the hysterectomy. Thirty-two women were enrolled in the study, 16 received preemptive analgesia while 14 were treated by placebo; 2 were excluded. All operations were performed under general anesthesia. The standard postoperative pain treatment consisted of oral analgesia with ibuprofen (400 mg) in liquid-filled capsules. Morphine (10 mg) was used for rescue analgesia. Pain intensity was self-evaluated with the use of a 100 mm visual analog scale.
  
  
  RESULTS
  Compared to the placebo group, women who received preemptive analgesia with lidocaine 1% perceived a significant reduction in postoperative pain in the first hours after surgery (2 h: 50.1+/-27.9 versus 70.6+/-22.6, p=0.043; 5 h: 42.5+/-25.2 versus 64.6+/-28.3, p=0.043; 8 h: 31.2+/-22.4 versus 53.3+/-30.3, p=0.031).
  
  
  CONCLUSIONS
  Preemptive analgesia with lidocaine 1% is a simple, cheap and efficient mode to reduce pain in the first hours after hysterectomy.
authors.affiliation: Department of Obstetrics and Gynecology, Rambam Medical Center, Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
authors.forename: Lior
authors.initials: L
authors.lastname: Lowenstein
authors.forename: Etan Z
authors.initials: EZ
authors.lastname: Zimmer
authors.forename: Michael
authors.initials: M
authors.lastname: Deutsch
authors.forename: Yuri
authors.initials: Y
authors.lastname: Paz
authors.forename: Dina
authors.initials: D
authors.lastname: Yaniv
authors.forename: Peter
authors.initials: P
authors.lastname: Jakobi
mesh_terms: D000328:Adult; D000779:Anesthetics, Local / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007044:Hysterectomy / Q000009:adverse effects*; D007889:Leiomyoma / Q000601:surgery; D008012:Lidocaine / Q000008:administration & dosage*; D008875:Middle Aged; D010149:Postoperative Pain / Q000188:drug therapy*; D011446:Prospective Studies; D014594:Uterine Neoplasms / Q000601:surgery
chemical_list: D000779:Anesthetics, Local; D008012:Lidocaine