Ubiquitin hubs in oncogenic networks.
Ubiquitin is an important regulator of diverse biological functions including cell cycle progression, apoptosis, cell proliferation, and DNA damage responses. Crucial proteins involved in the control of such diverse functions are modified by ubiquitin and are frequently altered during oncogenesis. Here, we define such proteins as key-nodes regulated by ubiquitin, discuss examples of their oncogenic aberrations, and indicate how pharmacologic manipulation of such molecular hubs might improve anticancer therapy.
Crosetto
Nicola
N
Institute of Biochemistry II, Goethe University Hospital, Frankfort on the Main, Germany.
Bienko
Marzena
M
Dikic
Ivan
I
D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D002453:Cell Cycle / Q000502:physiology*; D049109:Cell Proliferation; D004249:DNA Damage / Q000502:physiology*; D006801:Humans; D016328:NF-kappa B / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology; D016212:Transforming Growth Factor beta / Q000502:physiology; D025801:Ubiquitin / Q000502:physiology*; D051153:Wnt Proteins / Q000502:physiology
D016328:NF-kappa B; D016212:Transforming Growth Factor beta; D025801:Ubiquitin; D051153:Wnt Proteins