The sodium salt of diethyl 1H-pyrazole-3,5-dicarboxylate as an efficient amphiphilic receptor for dopamine and amphetamines. crystal structure and solution studies.
The sodium salt of the diethyl 1H-pyrazole-3,5-dicarboxylate (2) of amphiphilic character is able to interact with (+)-amphetamine, (+)-methamphetamine, and dopamine, yielding stable complexes. Crystal structure of 2 with (+)-amphetamine leads to a very nice double helical supramolecular structure.
Reviriego
Felipe
F
Instituto de Química Médica, Centro de Química Orgánica Manuel Lora Tamayo, CSIC, Juan de la Cierva 3, 28006 Madrid, Spain.
Rodríguez-Franco
Maria Isabel
MI
Navarro
Pilar
P
García-España
Enrique
E
Liu-Gonzalez
Malva
M
Verdejo
Begoña
B
Domènech
Antonio
A
D000662:Amphetamines / Q000737:chemistry*; D002264:Carboxylic Acids / Q000737:chemistry*; D003460:Crystallization; D018360:Crystallography, X-Ray; D004298:Dopamine / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D011720:Pyrazoles / Q000737:chemistry*; D012492:Salts / Q000737:chemistry; D012996:Solutions / Q000737:chemistry; D013237:Stereoisomerism; D014867:Water / Q000737:chemistry
D000662:Amphetamines; D002264:Carboxylic Acids; D011720:Pyrazoles; D012492:Salts; D012996:Solutions; C516857:diethyl 1H-pyrazole-3,5-dicarboxylate; D014867:Water; D004298:Dopamine