title: Cytotoxic farnesyl glycosides from Pittosporum pancheri.
abstract: Bioassay guided purification of the ethanolic extract of the bark of New Caledonian Pittosporum pancheri Brongn. and Gris (Pittosporaceae) led to the isolation and characterization of two new farnesyl monoglycosides, pancherins A and B. The structure of these compounds were determined on the basis of spectroscopic studies. The new compounds displayed a significant activity in the in vitro cytotoxic assay against KB cancer cell line, and pancherin A inhibits weakly farnesyl protein transferase.
authors.affiliation: Institut de Chimie des Substances Naturelles, CNRS, 1 Avenue de la Terrasse, 91198 Gif-sur-Yvette Cedex, France.
authors.forename: Véronique
authors.initials: V
authors.lastname: Eparvier
authors.forename: Odile
authors.initials: O
authors.lastname: Thoison
authors.forename: Hadjira
authors.initials: H
authors.lastname: Bousserouel
authors.forename: Françoise
authors.initials: F
authors.lastname: Guéritte
authors.forename: Thierry
authors.initials: T
authors.lastname: Sévenet
authors.forename: Marc
authors.initials: M
authors.lastname: Litaudon
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D006801:Humans; D007624:KB Cells / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology; D018547:Plant Stems / Q000737:chemistry; D019685:Rosales / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
chemical_list: D000970:Antineoplastic Agents; D006027:Glycosides; D010936:Plant Extracts; D012717:Sesquiterpenes