Ethanol-related traits in mice selectively bred for differential sensitivity to methamphetamine-induced activation.
Acute drug stimulation has been proposed to be an endophenotype for drug abuse. The authors previously reported the short-term selective breeding of lines of mice for low (LMACT) and high (HMACT) stimulation to methamphetamine (MA). These mice were used to examine whether common genes influence the locomotor response to MA and ethanol. Additionally, the authors tested these mice for ethanol drinking, locomotor sensitization, and clearance. LMACT mice were less stimulated by ethanol and consumed more ethanol than HMACT mice, but the lines did not differ in ethanol-induced sensitization. A small difference in ethanol clearance rate (0.1 mg/ml/h) likely had little impact on behavior. Some common genes may influence the locomotor response to MA and ethanol, as well as ethanol drinking.
Kamens
Helen M
HM
Department of Behavioral Neuroscience, Portland Alcohol Research Center, Oregon Health & Science University, OR, USA.
Burkhart-Kasch
Sue
S
McKinnon
Carrie S
CS
Li
Na
N
Reed
Cheryl
C
Phillips
Tamara J
TJ
D000428:Alcohol Drinking; D000704:Analysis of Variance; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D002492:Central Nervous System Depressants / Q000097:blood / Q000494:pharmacology*; D000697:Central Nervous System Stimulants / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D000431:Ethanol / Q000097:blood / Q000494:pharmacology*; D008694:Methamphetamine / Q000494:pharmacology*; D051379:Mice; D008810:Mice, Inbred C57BL; D009043:Motor Activity / Q000187:drug effects* / Q000235:genetics; D012641:Selection, Genetic
D002492:Central Nervous System Depressants; D000697:Central Nervous System Stimulants; D000431:Ethanol; D008694:Methamphetamine