title: [Value of radioguided surgery with dobutamine 99mTc-MIBI in persistent secondary hyperparathyroidism].
abstract: 99mTc-MIBI is a radiopharmaceutical that has been successfully used for the detection of hyperfunctioning parathyroid glands and for radioguided surgery techniques. We report on the case of a 55 year old woman in hemodialysis, with secondary persistent hyperparathyroidism after total parathyroidectomy. The conventional double-phase 99mTc-MIBI parathyroid scintigraphy was negative. The study was repeated after sensibilization with intravenous low-dose dobutamine showing an area of increased focal uptake in the lower cervical region. With this finding, radioguided 99mTc-MIBI surgery was performed after dobutamine administration, using a hand held gamma probe. The technique was considered successful with the resection of parathyroid cervical tissue which was further confirmed as nodular hyperplasia. We conclude that this methodology has the potential of being a an useful tool for the intraoperative localization of remanent tissue in patients with secondary persistent/recurrent hyperparathyroidism.
authors.affiliation: Centro de Medicina Nuclear, Hospital de Clínicas, Universidad de la República, Montevideo, Uruguay.
authors.forename: A
authors.initials: A
authors.lastname: Quagliata
authors.forename: J J
authors.initials: JJ
authors.lastname: López
authors.forename: C
authors.initials: C
authors.lastname: Juri
authors.forename: O
authors.initials: O
authors.lastname: Alonso
mesh_terms: D004280:Dobutamine; D005260:Female; D006801:Humans; D006962:Hyperparathyroidism, Secondary / Q000000981:diagnostic imaging* / Q000601:surgery*; D008875:Middle Aged; D016105:Parathyroidectomy / Q000379:methods*; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D017256:Technetium Tc 99m Sestamibi
chemical_list: D019275:Radiopharmaceuticals; D004280:Dobutamine; D017256:Technetium Tc 99m Sestamibi