title: Electrochemical determination of dipyridamole at a carbon paste electrode using cetyltrimethyl ammonium bromide as enhancing element.
abstract: Electrochemical behaviors of dipyridamole (DIP) at a carbon paste electrode in the presence of cetyltrimethyl ammonium bromide (CTAB) were investigated by voltammetry, chronocoulometry and electrochemical impedance spectroscopy (EIS). The results indicated that the electrochemical responses of DIP are apparently improved by CTAB, due to the enhanced accumulation of dipyridamole at the carbon paste electrode surface. Electrochemical parameters for the oxidation of DIP were explored by chronocoulometry. Under optimal conditions, the oxidation peak current at 0.53 V was proportional to DIP concentration in the range of 0.03-12 microg mL-1, with a detection limit of 0.01 microg mL-1 for 120 s accumulation by different pulse voltammetry (DPV). This method was applied to the determination of DIP in the tablet samples. The results were satisfying compared with that obtained by standardized method of high performance liquid chromatography (HPLC).
authors.affiliation: College of Chemistry and Materials Science, South-Central University for Nationalities, Wuhan 430074, China. lichychem@163.com
authors.forename: Chunya
authors.initials: C
authors.lastname: Li
mesh_terms: D002244:Carbon / Q000737:chemistry*; D000077286:Cetrimonium; D002593:Cetrimonium Compounds / Q000737:chemistry*; D004176:Dipyridamole / Q000032:analysis*; D004563:Electrochemistry; D004566:Electrodes; D006863:Hydrogen-Ion Concentration; D015394:Molecular Structure; D010084:Oxidation-Reduction; D013499:Surface Properties; D013501:Surface-Active Agents / Q000737:chemistry; D013997:Time Factors
chemical_list: D002593:Cetrimonium Compounds; D013501:Surface-Active Agents; D004176:Dipyridamole; D002244:Carbon; D000077286:Cetrimonium