Endomorphin-1 analogs with enhanced metabolic stability and systemic analgesic activity: design, synthesis, and pharmacological characterization.
We synthesized four new analogs of endomorphin-1 by systematic chemical modifications. To identify the best possible drug candidates for clinical pain management and to investigate the potential contribution of these alterations to the biological activity, their pharmacological properties were determined. All of the analogs showed significantly enhanced metabolic stability. The fact that centrally mediated analgesia following peripheral administration was observed with one of the analogs suggested the approach design undertaken here had validity in the development of endomorphin-1 as a successful opioid drug for the clinic.
Liu
Hongmei
H
State Key Laboratory of Applied Organic Chemistry, and Institute of Biochemistry and Molecular Biology, School of Life Sciences, Lanzhou University, Lanzhou 730000, People's Republic of China.
Zhang
Bangzhi
B
Liu
Xuefeng
X
Wang
Changlin
C
Ni
Jingman
J
Wang
Rui
R
D000700:Analgesics / Q000138:chemical synthesis* / Q000494:pharmacology; D000701:Analgesics, Opioid; D000818:Animals; D015195:Drug Design; D004355:Drug Stability; D051379:Mice; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000494:pharmacology*; D010146:Pain / Q000188:drug therapy; D010599:Pharmacokinetics
D000700:Analgesics; D000701:Analgesics, Opioid; D009842:Oligopeptides; C105293:endomorphin 1