[The role of intravascular autorossette-formation in the onset of anemia in patients with chronic cardiac failure].
OBJECTIVE
To study intensity of intravascular autorossette-formation (ARF) and its role in development of anemia in patients with chronic heart failure (CHF).


METHODS
Blood smears (Romanovsky-Gimze stain) were obtained from 210 patients with CHF (functional class I-III) treated as indicated. Total number of autorossettes (AR) and AR with red cell lysis in them were calculated in the blood smears.


RESULTS
The number of endogenic AR increases with higher functional class of CHF, duration of the disease, number of drugs. With increasing number of AR and AR with exocytic lysis, number of red cells and blood hemoglobin concentration lower.


CONCLUSIONS
It is suggested that phenomenon of intravascular autorossette-formation is involved in pathogenesis of anemia in CHF patients and a cause of anemia may be much more complicated that it was thought initially.
Volkov
V S
VS
Korichkina
L N
LN
Solov'eva
A V
AV
D000368:Aged; D000740:Anemia / Q000209:etiology*; D002196:Capillaries / Q000473:pathology; D002303:Cardiac Output, Low / Q000150:complications*; D016022:Case-Control Studies; D004906:Erythrocyte Count; D004912:Erythrocytes / Q000473:pathology*; D005260:Female; D006454:Hemoglobins / Q000032:analysis; D006461:Hemolysis; D006801:Humans; D008297:Male; D009000:Monocytes / Q000473:pathology; D009504:Neutrophils / Q000473:pathology
D006454:Hemoglobins