title: Use of nonsteroidal antiinflammatory drugs in dental practice. A review.
abstract: Nonsteroidal antiinflammatory drugs (NSAIDs) are drugs commonly prescribed in dental practice for the management of pain and swelling. Of these substances, paracetamol and ibuprofen are the most widely used. Their mechanism of action is based on the inhibition of cyclooxygenase, and therefore of prostaglandin synthesis. All of these drugs present a similar mechanism of action, as a result of which their side effects are also similar. The most frequent range from mild (e.g., nausea or vomiting) to serious gastric problems (such as gastric bleeding or perforation). Other side effects include an increased risk of vascular accidents (particularly acute myocardial infarction), renal toxicity secondary to a decrease in perfusion, and the risk of abnormal bleeding tendency due to the antiplatelet effect of these drugs. Their use is contraindicated in the third trimester of pregnancy, due to the induction of premature ductus arteriosus closure. The present study reviews the information currently available on NSAIDs, with special emphasis on those aspects related to dental practice.
authors.affiliation: Service of Stomatology. Valencia University General Hospital, Spain. poveda_raf@gva.es
authors.forename: Rafael
authors.initials: R
authors.lastname: Poveda Roda
authors.forename: José Vicente
authors.initials: JV
authors.lastname: Bagán
authors.forename: Yolanda
authors.initials: Y
authors.lastname: Jiménez Soriano
authors.forename: Lola
authors.initials: L
authors.lastname: Gallud Romero
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects / Q000627:therapeutic use*; D016861:Cyclooxygenase Inhibitors / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D009059:Mouth Diseases / Q000188:drug therapy*; D010146:Pain / Q000188:drug therapy*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D016861:Cyclooxygenase Inhibitors