title: Premorbid exercising in specific cognitive tasks prevents impairment of performance in parkinsonian monkeys.
abstract: Adult Cebus apella monkeys were exposed to either one, two or four series of cognitive tasks that place a demand on working memory and inhibitory control (Spatial Delayed Response and Object Retrieval Detour), before administration of the neurotoxin 1-methyl-1-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Following MPTP treatment, monkeys receiving more than one series successfully reached criteria at delays similar to those attained during the pre-MPTP stage for the Spatial Delayed Response task and avoided increased perseveration in the Object Retrieval Detour task. Results provide evidence that protection towards a neurotoxin in specific cognitive performances can be increased by repeated exposure to task-specific cognitive demands and that motor and cognitive impairment following MPTP treatment can be effectively dissociated in primates.
authors.affiliation: Unidad de Neurobiología Aplicada (UNA) (CEMIC), Av. Galván 4102 C1431FWO, Buenos Aires, Argentina.
authors.forename: Sebastián J
authors.initials: SJ
authors.lastname: Lipina
authors.forename: Jorge A
authors.initials: JA
authors.lastname: Colombo
mesh_terms: D000818:Animals; D001521:Behavior Therapy / Q000379:methods*; D015415:Biomarkers / Q000032:analysis / Q000378:metabolism; D002428:Cebus; D003072:Cognition Disorders / Q000209:etiology / Q000517:prevention & control / Q000628:therapy*; D015928:Cognitive Behavioral Therapy / Q000379:methods*; D018450:Disease Progression; D004298:Dopamine / Q000096:biosynthesis; D007150:Immunohistochemistry; D008297:Male; D009473:Neuronal Plasticity / Q000502:physiology; D009483:Neuropsychological Tests / Q000592:standards*; D020734:Parkinsonian Disorders / Q000150:complications* / Q000503:physiopathology / Q000523:psychology*; D011597:Psychomotor Performance / Q000187:drug effects / Q000502:physiology; D020127:Recovery of Function / Q000502:physiology; D013378:Substantia Nigra / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology; D014446:Tyrosine 3-Monooxygenase / Q000032:analysis / Q000378:metabolism
chemical_list: D015415:Biomarkers; D014446:Tyrosine 3-Monooxygenase; D004298:Dopamine