title: Central neurocytoma: a clinico-pathological study of eight cases.
abstract: Central neurocytomas are benign neuronal tumours generally found in the lateral or third ventricles. They are rare, comprising < 1% of all brain tumours. It is frequently confused with other tumours of the central nervous system particularly oligodendroglioma. The present study was done to analyse the histopathological features including immunohistochemical profile of these rare tumours. Eight cases were taken up for the study. Seven of the cases had an intraventricular location and one was located outside the ventricles. Increased intracranial pressure was the most common presenting symptom. Microscopically all tumours were composed of small uniform cells with perinuclear halos and regular round nuclei. The tumour in extraventricular location showed atypical features. Immunohistochemistry showed positivity for neuronal markers. The present series highlights the characteristic clinical and pathological findings of this rare brain tumour. Immunostaining for neuronal markers are essential for distinguishing them from other small round cell tumours of the brain.
authors.affiliation: Department of Histopathology, Post Graduate Institute of Medical Education and Research, Chandigarh 160012.
authors.forename: L S
authors.initials: LS
authors.lastname: Rajesh
authors.forename: Deepali
authors.initials: D
authors.lastname: Jain
authors.forename: B D
authors.initials: BD
authors.lastname: Radotra
authors.forename: A K
authors.initials: AK
authors.lastname: Banerjee
authors.forename: V K
authors.initials: VK
authors.lastname: Khosla
authors.forename: R K
authors.initials: RK
authors.lastname: Vasishta
mesh_terms: D000293:Adolescent; D000328:Adult; D002551:Cerebral Ventricle Neoplasms / Q000473:pathology* / Q000503:physiopathology*; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D019586:Intracranial Hypertension; D008297:Male; D009419:Nerve Tissue Proteins / Q000378:metabolism; D018306:Neurocytoma / Q000473:pathology* / Q000503:physiopathology*; D009474:Neurons / Q000378:metabolism*; D016708:Synaptophysin / Q000378:metabolism
chemical_list: D009419:Nerve Tissue Proteins; D016708:Synaptophysin