title: Characterization of a line of pigs previously selected for increased litter size for RBP4 and follistatin.
abstract: The objective of this study was to determine if selection response for increased litter size in pigs could be partially attributed to three type 1 marker loci coding for genes known to affect litter size: oestrogen receptor (ESR), retinol-binding protein 4 (RBP4) and follistatin (FS). In the high litter size line (LS), pigs from the largest litters, based on number of pigs born alive (NBA), were retained to parent the next generation. A randomly selected control line (LC) was maintained. Gilts were reared in litters of 10 pigs or less to minimize maternal effects. Pigs were measured at generations 10-12. Additional traits scored were number of fully formed pigs (NFF) and number of mummified fetuses (MUM). Breeding values for NFF and NBA were greater (p < 0.05) in LS than LC in generations 11 and 12, but no significant line differences were found for MUM. The A allele of the ESR locus was fixed in both lines. After adjustment for effects of genetic drift, frequency of the two alleles segregating for the FS and RBP4 loci did not differ significantly between lines. No significant additive or dominance effects of the FS markers were detected for NFF, NBA and MUM in either LS or LC. Response to selection for increased litter size could not be attributed to effects at the ESR, RBP4 or FS loci.
authors.affiliation: Department of Animal Science, North Carolina State University, Raleigh, NC 27695-7621, USA.
authors.forename: C D
authors.initials: CD
authors.lastname: Blowe
authors.forename: K E
authors.initials: KE
authors.lastname: Boyette
authors.forename: M S
authors.initials: MS
authors.lastname: Ashwell
authors.forename: E J
authors.initials: EJ
authors.lastname: Eisen
authors.forename: O W
authors.initials: OW
authors.lastname: Robison
authors.forename: J P
authors.initials: JP
authors.lastname: Cassady
mesh_terms: D000818:Animals; D005260:Female; D038681:Follistatin / Q000235:genetics*; D008098:Litter Size / Q000235:genetics*; D008297:Male; D016133:Polymerase Chain Reaction; D011247:Pregnancy; D011960:Receptors, Estrogen / Q000235:genetics; D012177:Retinol-Binding Proteins / Q000235:genetics*; D034421:Sus scrofa / Q000235:genetics* / Q000502:physiology
chemical_list: D038681:Follistatin; D011960:Receptors, Estrogen; D012177:Retinol-Binding Proteins