title: Histopathologic study of long-bone growth plates confirms the basset hound as an osteochondrodysplastic breed.
abstract: Osteochondrodysplasias are caused by abnormal development and growth of cartilage and bone. These abnormalities have been reported in both humans and animals with dwarfism. The basset hound is considered a breed with a disproportionate prevalence of dwarfism, the cause of which is unknown. To determine the type of osteochondrodysplasia in this breed, we analyzed histologically the growth plates from the long bones of a basset hound and a Doberman pinscher, both 2 mo old. Tissue was fixed in 4% paraformaldehyde, embedded in paraffin, sectioned at 5 microm, stained with hematoxylin and eosin, and analyzed by light microscopy. Our results suggest that by this method the basset hound can be defined only as a breed having osteochondrodysplasia due to a primary cartilage problem in the growth plate.
authors.affiliation: Centro de Investigaciones y de Estudios Avanzados en Salud Animal, Facultad de Medicina Veterinaria y Zootecnia, Universidad Autónoma del Estado de México, Toluca Edo. México. simonmc@uaemex.mx
authors.forename: Simón
authors.initials: S
authors.lastname: Martínez
authors.forename: Raúl
authors.initials: R
authors.lastname: Fajardo
authors.forename: Jesús
authors.initials: J
authors.lastname: Valdés
authors.forename: Raúl
authors.initials: R
authors.lastname: Ulloa-Arvizu
authors.forename: Rogelio
authors.initials: R
authors.lastname: Alonso
mesh_terms: D000818:Animals; D001842:Bone and Bones / Q000000981:diagnostic imaging / Q000473:pathology; D002356:Cartilage / Q000000981:diagnostic imaging / Q000473:pathology; D004283:Dog Diseases / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology; D004285:Dogs; D005260:Female; D006132:Growth Plate / Q000000981:diagnostic imaging / Q000473:pathology*; D008297:Male; D010009:Osteochondrodysplasias / Q000453:epidemiology / Q000235:genetics / Q000473:pathology / Q000662:veterinary*; D010375:Pedigree; D015995:Prevalence; D011859:Radiography