New chemical constituents from the endophyte Streptomyces species LR4612 cultivated on Maytenus hookeri.
From solid cultures of the biologically important endophyte Streptomyces species LR4612, cultivated on Maytenus hookeri, four new and two known compounds were isolated. The new compounds were identified as (2S*,3S*)-5-amino-3-hydroxy-5-oxopentan-2-yl 3-(formylamino)-2-hydroxybenzoate (1), N-[(3R*,4R*)-3-amino-3,4-dihydro-4-methyl-2,6-dioxo-2H,6H-1,5-benzodioxocin-10-yl]formamide (2), (5beta,6alpha)-6,11-dihydroxyeudesmane (3), and 5-(6,7-dihydroxy-6-methyloctyl)furan-2(5H)-one (4); the known compounds were elucidated as sorbicillin (5) and N-acetyltyramine (6). The structures were established by HR-ESI-MS and in-depth NMR analyses.
Zhao
Pei-Ji
PJ
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Science, Kunming 650204, Yunnan, PR China.
Li
Guo-Hong
GH
Shen
Yue-Mao
YM
D029755:Maytenus / Q000382:microbiology*; D018517:Plant Roots / Q000382:microbiology; D013302:Streptomyces / Q000737:chemistry* / Q000254:growth & development* / Q000302:isolation & purification