title: High serum soluble CD30 does not predict acute rejection in liver transplant patients.
abstract: Increased pre- and posttransplantation values of soluble CD30 (sCD30) have been shown to be associated with acute kidney transplant rejection. We sought to study whether high sCD30 could predict rejection early after liver transplantation. The study population included 54 consecutive liver transplant patients, whose samples were collected before liver transplantation and at discharge, which was at a mean time of 3 weeks after transplantation. During the first 6 months posttransplantation, 22 patients experienced an acute rejection episode. Serum sCD30 concentrations were measured by an enzyme-linked immunoassay; changes in serum sCD30 levels posttransplantation were also expressed as relative values compared with pretransplantation results. Liver patients before transplantation displayed higher serum sCD30 values compared with healthy controls: mean values +/- SD were 93 +/- 58 IU/mL vs 17 +/- 8 IU/mL, respectively. At 3 weeks after transplantation the mean sCD30 concentration in liver transplant patients decreased to 59 +/- 42 IU/mL (P = .005). The mean pretransplantation serum sCD30 value was slightly lower among rejecting vs nonrejecting patients: 78 +/- 43 IU/mL vs 104 +/- 65 IU/mL (P = NS). Posttransplantation values in both groups decreased significantly: 47 +/- 34 IU/mL in patients with rejection (P = .014) vs 69 +/- 45 IU/mL in patients without rejection (P = .012). The relative value at 3 weeks posttransplantation decreased slightly more among patients with vs without rejection (70% vs 88%; NS). No correlation was found between serum sCD30 and anti-HLA class I antibodies or crossmatch positivity. In conclusion, neither pre- nor posttransplantation sCD30 levels were associated with acute rejection in liver transplant patients.
authors.affiliation: Department of Clinical Chemistry, Kuopio University Hospital, Kuopio, Finland. irma.matinlauri@kuh.fi
authors.forename: I
authors.initials: I
authors.lastname: Matinlauri
authors.forename: K
authors.initials: K
authors.lastname: Höckerstedt
authors.forename: H
authors.initials: H
authors.lastname: Isoniemi
mesh_terms: D000208:Acute Disease; D015415:Biomarkers / Q000097:blood; D006084:Graft Rejection / Q000097:blood* / Q000276:immunology; D006801:Humans; D017730:Ki-1 Antigen / Q000097:blood*; D008107:Liver Diseases / Q000145:classification / Q000601:surgery; D016031:Liver Transplantation / Q000276:immunology / Q000502:physiology*; D011184:Postoperative Period; D011237:Predictive Value of Tests; D011300:Preoperative Care; D012086:Reoperation; D015203:Reproducibility of Results
chemical_list: D015415:Biomarkers; D017730:Ki-1 Antigen