Estrogens and aspects of prostate disease.
Estrogens have long been associated with the processes involved in prostate carcinogenesis, particularly in cancer suppression. However, the synergistic influence of low concentrations of estrogens, together with androgens, in promoting aberrant growth of the gland has also been recognized. As new insights into the complex molecular events implicated in growth regulation of the prostate are revealed, the role of the estrogens has become clearer. The present review considers this role in relation to the pathogenesis of prostate cancer and the potential cancer-repressive influence of the dietary estrogens.
Prezioso
Domenico
D
Oncology Center, Antwerpen, Belgium.
Denis
Louis J
LJ
Klocker
Helmut
H
Sciarra
Alexandria
A
Reis
Mario
M
Naber
Kurt
K
Lobel
Bernard
B
Pacik
Dalibor
D
Griffiths
Keith
K
D004967:Estrogens / Q000009:adverse effects / Q000502:physiology*; D006801:Humans; D008297:Male; D017410:Practice Guidelines as Topic; D011469:Prostatic Diseases / Q000188:drug therapy / Q000209:etiology*; D011471:Prostatic Neoplasms / Q000209:etiology* / Q000235:genetics; D011472:Prostatitis / Q000209:etiology
D004967:Estrogens