Chloro- and bromophenols from cultures of Mycena alcalina.
Three new chlorinated phenols have been isolated from mycelial cultures of the mushroom Mycena alcalina. Their structures were determined by mass spectrometry and 1D and 2D NMR experiments. Addition of bromide to the medium resulted in the production of the corresponding brominated phenols. In addition, small amounts of the nonhalogenated precursor were also isolated, indicating that the halogenated metabolites are generated by a regioselectively operating halogenase.
Peters
Silke
S
Institut für Organische Chemie und Biochemie II der Technischen Universität München, Lichtenbergstrasse 4, D-85747 Garching, Germany.
Spiteller
Peter
P
D000363:Agaricales / Q000737:chemistry*; D002733:Chlorophenols / Q000737:chemistry / Q000302:isolation & purification*; D006842:Hydrocarbons, Brominated / Q000737:chemistry / Q000302:isolation & purification*; D019906:Nuclear Magnetic Resonance, Biomolecular; D010088:Oxidoreductases / Q000378:metabolism*; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification*; D013237:Stereoisomerism
D002733:Chlorophenols; D006842:Hydrocarbons, Brominated; D010636:Phenols; C516514:alcalinaphenol A; C516516:alcalinaphenol B; C516515:alcalinaphenol C; D010088:Oxidoreductases