The potential role of podoplanin in tumour invasion.
Podoplanin is a small mucin-like transmembrane protein, widely expressed in various specialised cell types throughout the body. Here, we revisit the mechanism of podoplanin-mediated tumour invasion. We compare molecular pathways leading to single and collective cell invasion and discuss novel distinct concepts of tumour cell invasion.
Wicki
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A
Department of Clinical-Biological Sciences, Institute of Biochemistry and Genetics, Centre for Biomedicine, University of Basel, Basel, Switzerland.
Christofori
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G
D000199:Actins / Q000378:metabolism; D000818:Animals; D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism; D002465:Cell Movement; D003599:Cytoskeleton / Q000378:metabolism; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics; D006801:Humans; D008562:Membrane Glycoproteins / Q000235:genetics / Q000378:metabolism*; D051379:Mice; D009361:Neoplasm Invasiveness / Q000473:pathology / Q000503:physiopathology*; D009369:Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy; D000098853:Podoplanin
D000199:Actins; D014408:Biomarkers, Tumor; D008562:Membrane Glycoproteins; C490441:Pdpn protein, mouse; D000098853:Podoplanin; C117468:PDPN protein, human