A new destruxin as inhibitor of vacuolar-type H+-ATPase of Saccharomyces cerevisiae.
In the course of our screening efforts to discover small molecules as selective inhibitors of vacuolar-type H+-ATPase of Saccharomyces cerevisiae, we have identified eight active destruxins, 1-8, from the fungus Metarhizium anisopliae. The structures were elucidated by extensive 1D- and 2D-NMR spectroscopy, and MS spectrometry. One of these compounds, 8, a regioisomer of chlorohydrin destruxin E (7), is a new destruxin.
Vázquez
María J
MJ
Assay Development and Compound Profiling Department, GlaxoSmithKline, R&D, Centro de Investigación Básica, Santiago Grisolía 4, E-28760 Tres Cantos, Madrid. maria-jesus.vazquez@gsk.com
Albarrán
María I
MI
Espada
Alfonso
A
Rivera-Sagredo
Alfonso
A
Díez
Emilio
E
Hueso-Rodríguez
Juan A
JA
D000818:Animals; D002645:Chickens; D047630:Depsipeptides / Q000378:metabolism* / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005285:Fermentation; D020128:Inhibitory Concentration 50; D052981:Metarhizium / Q000378:metabolism; D015394:Molecular Structure; D010010:Osteoclasts; D012441:Saccharomyces cerevisiae / Q000201:enzymology*; D013997:Time Factors; D025262:Vacuolar Proton-Translocating ATPases / Q000037:antagonists & inhibitors* / Q000378:metabolism
D047630:Depsipeptides; D025262:Vacuolar Proton-Translocating ATPases