Autoimmune regulator (AIRE) gene is expressed in human activated CD4+ T-cells and regulated by mitogen-activated protein kinase pathway.
The autoimmune regulator (AIRE) gene is a gene responsible for autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. Here we show that AIRE is expressed in human peripheral CD4-positive T-cells, and most highly in antigen-and interleukin 2-stimulated T (IL-2T) cells. Mitogen-activated protein kinases (MAPKs), including MAPK kinase (MEK) 1/2 and p38 MAPK, were phosphorylated in IL-2T cells and the expression of the AIRE gene was inhibited by a specific p38 MAPK inhibitor (SB203580), thereby indicating that AIRE gene expression is controlled by the MAPK pathway in IL-2T cells. These data suggested the possible significance of the AIRE gene in the peripheral immune system.
Nagafuchi
Seiho
S
Department of Medical Science and Technology, School of Medicine, Kyushu University, Fukuoka, Japan. nagafuchi@shs.kyushu-u.ac.jp
Katsuta
Hitoshi
H
Koyanagi-Katsuta
Rimiko
R
Yamasaki
Satoshi
S
Inoue
Yasushi
Y
Shimoda
Kazuya
K
Ikeda
Yukari
Y
Shindo
Mieko
M
Yoshida
Eiko
E
Matsuo
Tomohito
T
Ohno
Yuju
Y
Kogawa
Kazuhiko
K
Anzai
Keizo
K
Kurisaki
Hironori
H
Kudoh
Jun
J
Harada
Mine
M
Shimizu
Nobuyoshi
N
D015496:CD4-Positive T-Lymphocytes / Q000378:metabolism*; D005809:Genes, Regulator; D006801:Humans; D020935:MAP Kinase Signaling System / Q000502:physiology; D020928:Mitogen-Activated Protein Kinases / Q000037:antagonists & inhibitors / Q000378:metabolism / Q000502:physiology*; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*; D000096927:AIRE Protein
D020928:Mitogen-Activated Protein Kinases; D014157:Transcription Factors; D000096927:AIRE Protein