Common gamma chain cytokines: dissidence in the details.
Cytokines of the common cytokine-receptor gamma-chain (gamma(c)) family are essential for the development and maintenance of lymphocytes. Herein, we will focus on the roles of interleukin-2 (IL-2), IL-7, IL-15 and IL-21, in the orchestration of CD8 T cell responses. Among these cytokines, IL-7 has emerged as a master regulator of survival of immature and mature T lymphocytes, while IL-2, IL-15 and IL-21 appear to have specific functions in T cell homeostasis and differentiation. Hence, the gamma(c) has evolved as an elegant anchor through which related cytokines regulate distinct biological responses in T cells.
Alves
Nuno L
NL
Department of Experimental Immunology, Academical Medical Center (AMC), Amsterdam, The Netherlands. n.m.lagesalves@amc.uva.nl
Arosa
Fernando A
FA
van Lier
René A W
RA
D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D002454:Cell Differentiation / Q000276:immunology / Q000502:physiology; D006706:Homeostasis / Q000276:immunology; D006801:Humans; D053631:Interleukin Receptor Common gamma Subunit / Q000819:agonists / Q000502:physiology; D007378:Interleukins / Q000502:physiology* / Q000627:therapeutic use; D008213:Lymphocyte Activation / Q000276:immunology
D053631:Interleukin Receptor Common gamma Subunit; D007378:Interleukins