title: Carinatumins A-C, new alkaloids from Lycopodium carinatum inhibiting acetylcholinesterase.
abstract: Three new Lycopodium alkaloids, carinatumins A-C (1-3), have been isolated from the club moss Lycopodium carinatum. Structures and stereochemistry of 1-3 were elucidated on the basis of 2D NMR correlations. Carinatumins A (1) and B (2) exhibited a potent inhibitory activity against acetylcholinesterase.
authors.affiliation: Faculty of Pharmaceutical Sciences, Hoshi University, Shinagawa-ku, Tokyo 142-8501, Japan.
authors.forename: Chee Yan
authors.initials: CY
authors.lastname: Choo
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Hirasawa
authors.forename: Chiaki
authors.initials: C
authors.lastname: Karimata
authors.forename: Koichiro
authors.initials: K
authors.lastname: Koyama
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Sekiguchi
authors.forename: Jun'ichi
authors.initials: J
authors.lastname: Kobayashi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Morita
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification; D002228:Carbenicillin / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology; D002800:Cholinesterase Inhibitors / Q000737:chemistry* / Q000302:isolation & purification*; D032502:Lycopodium / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry; D011728:Pyridones / Q000302:isolation & purification* / Q000494:pharmacology; D013237:Stereoisomerism
chemical_list: D000470:Alkaloids; D002800:Cholinesterase Inhibitors; D011728:Pyridones; C518511:carinatumin B; C518512:carinatumin C; C100244:carbenicillin indanyl; D002228:Carbenicillin