title: Structural properties of proteins specific to the myelin sheath.
abstract: The myelin sheath is an insulating membrane layer surrounding myelinated axons in vertebrates, which is formed when the plasma membrane of an oligodendrocyte or a Schwann cell wraps itself around the axon. A large fraction of the total protein in this membrane layer is comprised of only a small number of individual proteins, which have certain intriguing structural properties. The myelin proteins are implicated in a number of neurological diseases, including, for example, autoimmune diseases and peripheral neuropathies. In this review, the structural properties of a number of myelin-specific proteins are described.
authors.affiliation: Department of Biochemistry, University of Oulu, Oulu, Finland. petri.kursula@oulu.fi
authors.forename: P
authors.initials: P
authors.lastname: Kursula
mesh_terms: D063309:2',3'-Cyclic Nucleotide 3'-Phosphodiesterase; D000595:Amino Acid Sequence; D000818:Animals; D006801:Humans; D007136:Immunoglobulins / Q000737:chemistry; D008565:Membrane Proteins / Q000737:chemistry; D008958:Models, Molecular; D008969:Molecular Sequence Data; D004676:Myelin Basic Protein / Q000737:chemistry; D018993:Myelin P0 Protein / Q000737:chemistry; D009185:Myelin Proteins / Q000737:chemistry*; D009186:Myelin Sheath / Q000737:chemistry* / Q000648:ultrastructure; D018992:Myelin-Associated Glycoprotein / Q000737:chemistry; D063308:Myelin-Oligodendrocyte Glycoprotein; D010727:Phosphoric Diester Hydrolases / Q000737:chemistry; D017434:Protein Structure, Tertiary; D016415:Sequence Alignment; D033921:Vesicular Transport Proteins / Q000737:chemistry; D015032:Zinc / Q000032:analysis
chemical_list: D007136:Immunoglobulins; C571326:MOG protein, human; C501262:MYRIP protein, human; D008565:Membrane Proteins; D004676:Myelin Basic Protein; D018993:Myelin P0 Protein; D009185:Myelin Proteins; D018992:Myelin-Associated Glycoprotein; D063308:Myelin-Oligodendrocyte Glycoprotein; D033921:Vesicular Transport Proteins; C086745:periaxin; D010727:Phosphoric Diester Hydrolases; D063309:2',3'-Cyclic Nucleotide 3'-Phosphodiesterase; C571337:CNP protein, human; D015032:Zinc