Green tea extract thermogenesis-induced weight loss by epigallocatechin gallate inhibition of catechol-O-methyltransferase.
Epidemiological studies have shown that intake of tea catechins is associated with a lower risk of cardiovascular disease. The antioxidative activity of tea-derived catechins has been extensively studied. Reports have shown that green tea extract intake is associated with increased weight loss due to diet-induced thermogenesis, which is generally attributed to the catechin epigallocatechin gallate. That catechin-polyphenols are known to be capable of inhibiting catechol-O-methyltransferase (the enzyme that degrades norepinephrine) is a possible explanation for why the green tea extract is effective in stimulating thermogenesis by epigallocatechin gallate to augment and prolong sympathetic stimulation of thermogenesis. Knowledge about thermogenesis-induced weight loss produced by green tea's epigallocatechin gallate and its ability to inhibit catechol-O-methyltransferase is important for health benefits and for prolonging the action of norepinephrine in the synaptic cleft.
Shixian
Q
Q
South China Institute of Botany, Chinese Academy of Sciences, Guangzhou, China.
VanCrey
B
B
Shi
J
J
Kakuda
Y
Y
Jiang
Y
Y
D002001:Adipose Tissue, Brown / Q000378:metabolism; D000818:Animals; D028241:Camellia sinensis / Q000737:chemistry*; D002392:Catechin / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology; D065098:Catechol O-Methyltransferase Inhibitors; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D008297:Male; D008745:Methylation; D009638:Norepinephrine / Q000502:physiology; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D022722:Thermogenesis / Q000187:drug effects / Q000502:physiology*; D015431:Weight Loss
D065098:Catechol O-Methyltransferase Inhibitors; D004791:Enzyme Inhibitors; D010936:Plant Extracts; D002392:Catechin; C045651:epigallocatechin gallate; D009638:Norepinephrine