Mitochondrial complex I inhibition in Parkinson's disease: how can curcumin protect mitochondria?
Selective damage of mitochondrial complex I within the dopaminergic neurons of the substantia nigra is the central event during Parkinson disease. Peroxynitrite is one of the important free radicals probably mediating complex I damage. Peroxynitrite inhibits brain complex I mainly by 3-nitrotyrosine and nitrosothiol formation, but how these modifications alter the structure-function relation of complex I is unclear. Curcumin pretreatment protects brain mitochondria against peroxynitrite in vitro by direct detoxification and prevention of 3-nitrotyrosine formation and in vivo by elevation of total cellular glutathione levels. These results suggest a potential therapeutic role for curcumin against nitrosative stress in neurological disorders.
Mythri
Rajeswara Babu
RB
Department of Psychopharmacology, National Institute of Mental Health and Neurosciences, Bangalore, Karnataka, India.
Jagatha
Balusamy
B
Pradhan
Nityananda
N
Andersen
Julie
J
Bharath
M M Srinivas
MM
D003474:Curcumin / Q000494:pharmacology*; D042967:Electron Transport Complex I / Q000037:antagonists & inhibitors*; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D006801:Humans; D008928:Mitochondria / Q000187:drug effects* / Q000201:enzymology; D018696:Neuroprotective Agents / Q000494:pharmacology*; D010300:Parkinson Disease / Q000201:enzymology* / Q000517:prevention & control
D004791:Enzyme Inhibitors; D018696:Neuroprotective Agents; D042967:Electron Transport Complex I; D003474:Curcumin