Retrograde control of neural circuit formation.
Glial-derived neurotrophic factor (GDNF), secreted by skeletal muscle, triggers expression of the ETS transcription factor Pea3 in a subset of motor neurons in the spinal cord. In this issue, find that this retrograde GDNF-Pea3 signal controls dendrite patterning and assembly of a sensory-motor reflex circuit.
Deppmann
Christopher D
CD
The Solomon H. Snyder Department of Neuroscience, Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Ginty
David D
DD
D000818:Animals; D003712:Dendrites / Q000502:physiology*; D051100:Glial Cell Line-Derived Neurotrophic Factor / Q000494:pharmacology; D051379:Mice; D008959:Models, Neurological; D009046:Motor Neurons / Q000502:physiology*; D009132:Muscles / Q000378:metabolism; D015398:Signal Transduction; D013116:Spinal Cord / Q000033:anatomy & histology / Q000166:cytology*; D014157:Transcription Factors / Q000235:genetics*
D051100:Glial Cell Line-Derived Neurotrophic Factor; D014157:Transcription Factors; C065788:transcription factor PEA3