title: Markedly raised intake of saturated and monounsaturated fatty acids in rats on a high-fat ketogenic diet does not inhibit carbon recycling of 13C-alpha-linolenate.
abstract: Under various dietary and physiological conditions, carbon from alpha-linolenic acid (ALA) is extensively recycled into saturated and monounsaturated fatty acids. In this study we investigated whether carbon is still recycled from ALA when a dietary source of saturated and monounsaturated fatty acids is provided in excess. 13C-labeled ALA was given to rats consuming a high-fat ketogenic diet and to rats consuming a low-fat control diet. In rats on the ketogenic diet, 13C recycling from alpha-linolenate into several, but not all, saturated and monounsaturated fatty acids matched or exceeded that in the controls (P < 0.05). We conclude that carbon recycling into saturated and monounsaturated fatty acids persists when the main end products of ALA recycling are provided in excess, using a ketogenic diet.
authors.affiliation: Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada M5S 3E2.
authors.forename: Ameer Y
authors.initials: AY
authors.lastname: Taha
authors.forename: Mary Ann
authors.initials: MA
authors.lastname: Ryan
authors.forename: Stephen C
authors.initials: SC
authors.lastname: Cunnane
mesh_terms: D000818:Animals; D002244:Carbon / Q000378:metabolism*; D002247:Carbon Isotopes; D004032:Diet; D005227:Fatty Acids / Q000737:chemistry / Q000378:metabolism*; D005229:Fatty Acids, Monounsaturated / Q000378:metabolism; D050356:Lipid Metabolism; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D017962:alpha-Linolenic Acid / Q000378:metabolism*
chemical_list: D002247:Carbon Isotopes; D005227:Fatty Acids; D005229:Fatty Acids, Monounsaturated; D017962:alpha-Linolenic Acid; D002244:Carbon