title: To die or not to die: a HAT trick.
abstract: In this issue of Molecular Cell, two manuscripts (Sykes et al., 2006) propose that the decision to undergo apoptosis upon DNA damage is mediated through acetylation of p53 within its DNA-binding domain by MYST histone acetyltransferases.
authors.affiliation: LBME, CNRS and Université Paul Sabatier, 118 Route de Narbonne, 31062 Toulouse, France.
authors.forename: Sandrine
authors.initials: S
authors.lastname: Tyteca
authors.forename: Gaëlle
authors.initials: G
authors.lastname: Legube
authors.forename: Didier
authors.initials: D
authors.lastname: Trouche
mesh_terms: D000107:Acetylation; D000818:Animals; D017209:Apoptosis; D051017:Apoptosis Regulatory Proteins / Q000378:metabolism; D002453:Cell Cycle; D050759:Cyclin-Dependent Kinase Inhibitor p21 / Q000378:metabolism; D051548:Histone Acetyltransferases / Q000378:metabolism* / Q000502:physiology*; D006801:Humans; D000074443:Lysine Acetyltransferase 5; D011518:Proto-Oncogene Proteins / Q000378:metabolism; D051736:Proto-Oncogene Proteins c-mdm2 / Q000378:metabolism; D015533:Transcriptional Activation; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*; D050880:p300-CBP Transcription Factors / Q000502:physiology
chemical_list: D051017:Apoptosis Regulatory Proteins; C438378:BBC3 protein, human; C493956:CDKN1A protein, human; D050759:Cyclin-Dependent Kinase Inhibitor p21; D011518:Proto-Oncogene Proteins; D016159:Tumor Suppressor Protein p53; D051548:Histone Acetyltransferases; C098489:KAT5 protein, human; C496552:KAT8 protein, human; D000074443:Lysine Acetyltransferase 5; D050880:p300-CBP Transcription Factors; C497206:MDM2 protein, human; D051736:Proto-Oncogene Proteins c-mdm2