Intestinal absorption of dietary carotenoids.
The assessment of carotenoid bioavailability has long been hampered by the limited knowledge of their absorption mechanisms. However, recent reports have elucidated important aspects of carotenoid digestion and absorption. Disruption of food matrix and increasing amounts of fat seem to enhance the absorption of carotenes to a larger extent than that of xanthophylls. Comparing different carotenoid species, xanthophylls seem to be more easily released from the food matrix and more efficiently micellized than the carotenes. On the other hand, carotenes are more efficiently taken up by the enterocytes. However, carotenoid emulsification and micellization steps are largely affected by the food matrix and dietary components, being the main determinant of carotenoid bioavailability from foodstuffs. Although the intestinal uptake of carotenoids has been thought to occur by simple diffusion, recent studies reported the existence of receptor-mediated transport of carotenoids in enterocytes. Comparisons between the intestinal absorption of a wide array of carotenoids would be useful to elucidate the absorption mechanism of each carotenoid species, in view of the recent indications that intestinal carotenoid uptake may involve the scavenger receptor class B type I and possibly other epithelial transporters. The unraveling of the whole mechanism underlying the absorption of carotenoids will be the challenge for future studies.
Yonekura
Lina
L
National Food Research Institute, Tsukuba, Ibaraki, Japan.
Nagao
Akihiko
A
D000818:Animals; D001692:Biological Transport; D002338:Carotenoids / Q000008:administration & dosage / Q000493:pharmacokinetics*; D004043:Dietary Fiber / Q000008:administration & dosage; D004058:Diffusion; D005227:Fatty Acids / Q000008:administration & dosage; D006801:Humans; D007408:Intestinal Absorption; D010840:Phytosterols / Q000008:administration & dosage; D051122:Scavenger Receptors, Class B / Q000502:physiology; D013395:Sucrose / Q000008:administration & dosage / Q000031:analogs & derivatives
D004043:Dietary Fiber; D005227:Fatty Acids; D010840:Phytosterols; C495124:SCARB1 protein, human; D051122:Scavenger Receptors, Class B; D002338:Carotenoids; D013395:Sucrose; C013692:sucrose polyester