Identification of a unique transgenic mouse line that develops megabladder, obstructive uropathy, and renal dysfunction.
Urinary tract malformations, obstructive uropathy, and hypoplasia/dysplasia are extremely important in terms of pediatric health care costs, with end-stage renal failure in children estimated to cost >$15 billion annually in the United States alone. Even so, little is known regarding the mechanisms that control these processes. Identified was a unique mutant mouse model that develops in utero megabladder, resulting in variable hydroureteronephrosis and chronic renal failure secondary to obstructive uropathy. These animals, designated mgb for megabladder, possess a primary defect in bladder smooth muscle development that is apparent by embryonic day 15. The mgb mouse represents an excellent model for the study of normal and pathogenic bladder development, including the postnatal progression of chronic renal failure that results from the development of in utero obstructive uropathy.
Singh
Sunita
S
Columbus Children's Research Institute, 700 Children's Drive, Suite WA 2014, Columbus, OH 43205, USA.
Robinson
Melissa
M
Nahi
Fatin
F
Coley
Brian
B
Robinson
Michael L
ML
Bates
Carlton M
CM
Kornacker
Karl
K
McHugh
Kirk M
KM
D000818:Animals; D002417:Cattle; D002869:Chromosome Aberrations; D003001:Cloning, Molecular; D018450:Disease Progression; D006360:Heat-Shock Proteins / Q000235:genetics*; D006720:Homozygote; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007674:Kidney Diseases / Q000235:genetics*; D008297:Male; D051379:Mice; D008822:Mice, Transgenic; D009130:Muscle, Smooth / Q000473:pathology; D027981:Symporters / Q000235:genetics*; D001743:Urinary Bladder / Q000002:abnormalities* / Q000473:pathology; D014570:Urologic Diseases / Q000235:genetics*
D006360:Heat-Shock Proteins; D027981:Symporters