title: Effect of bovine lactoferrin on the immune responses of captive bottlenosed dolphins (Tursiops truncatus) being transported over long distances.
abstract: Bovine lactoferrin was administered orally, in feed, to six bottlenosed dolphins (Tursiops truncatus) before they were transported for approximately six hours; their stress responses were compared with those of five untreated dolphins. During the journey the dolphins had an increased plasma concentration of cortisol, and lymphopenia, eosinopenia and mild neutrophilia, indicating a stress response. The administration of lactoferrin did not affect the function of the dolphins' polymorphonuclear leucocytes, but affected their leucogram by maintaining the number of circulating eosinophils.
authors.affiliation: Department of Advanced Clinical Medicine, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, 1-1 Gakuencho, Sakai-shi, Osaka 599-8531, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Noda
authors.forename: M
authors.initials: M
authors.lastname: Aoki
authors.forename: H
authors.initials: H
authors.lastname: Akiyoshi
authors.forename: H
authors.initials: H
authors.lastname: Asaki
authors.forename: T
authors.initials: T
authors.lastname: Ogata
authors.forename: K
authors.initials: K
authors.lastname: Yamauchi
authors.forename: T
authors.initials: T
authors.lastname: Shimada
authors.forename: F
authors.initials: F
authors.lastname: Ohashi
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000836:Animals, Zoo; D050681:Bottle-Nosed Dolphin / Q000097:blood* / Q000276:immunology*; D005260:Female; D006854:Hydrocortisone / Q000097:blood; D007781:Lactoferrin / Q000008:administration & dosage / Q000494:pharmacology*; D007958:Leukocyte Count / Q000662:veterinary; D018655:Lymphocyte Count / Q000662:veterinary; D011897:Random Allocation; D013312:Stress, Physiological / Q000097:blood / Q000188:drug therapy / Q000662:veterinary*; D014186:Transportation
chemical_list: D007781:Lactoferrin; D006854:Hydrocortisone