[High relationship between ciprofloxacin use and prevalence of ESBL Klebsiella pneumoniae].
BACKGROUND
To assess the relationship between ciprofloxacin use and the prevalence of extended spectrum betalactamases (ESBL) Klebsiella pneumoniae.


METHODS
Semestral mean values regarding use of antibiotic and prevalence of ESBL Kp were compared during 9 semesters using linear regression and coefficient of correlation.


RESULTS
The only statistically significant correlation was ciprofloxacin use and ESBL(+) K. pneumoniae prevalence, with a coefficient of correlation of 0.86 and p = 0.0027 using linear regression.


CONCLUSIONS
Ciprofloxacin use must be taking into account when considering infection control programs due to high prevalence rates of ESBL(+) K. pneumoniae in the hospital setting.
Bermejo
Joaquín
J
Departamento de Estadística, Hospital Español, Rosario, Argentina. jbermejo@uolsinectis.com.ar
Bencomo
Blanca
B
Arnesi
Nora
N
Lesnaberes
Patricia
P
Borda
Noemí
N
Notario
Rodolfo
R
D000900:Anti-Bacterial Agents / Q000009:adverse effects / Q000627:therapeutic use*; D002511:Cephalosporins / Q000009:adverse effects / Q000627:therapeutic use*; D002939:Ciprofloxacin / Q000009:adverse effects / Q000627:therapeutic use*; D003430:Cross-Sectional Studies; D024881:Drug Resistance, Bacterial; D006801:Humans; D007710:Klebsiella Infections / Q000188:drug therapy / Q000382:microbiology*; D007711:Klebsiella pneumoniae / Q000187:drug effects* / Q000201:enzymology; D008826:Microbial Sensitivity Tests; D012307:Risk Factors; D001618:beta-Lactamases / Q000096:biosynthesis* / Q000187:drug effects
D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D002939:Ciprofloxacin; D001618:beta-Lactamases