title: On the measurement of human osteosarcoma cell elastic modulus using shear assay experiments.
abstract: This paper presents a method for determining the elastic modulus of human osteosarcoma (HOS) cells. The method involves a combination of shear assay experiments and finite element analysis. Following in-situ observations of cell deformation during shear assay experiments, a digital image correlation (DIC) technique was used to determine the local displacement and strain fields. Finite element analysis was then used to determine the Young's moduli of HOS cells. This involved a match of the maximum shear stresses estimated from the experimental shear assay measurements and those calculated from finite element simulations.
authors.affiliation: Princeton Institute for Science and Technology of Materials (PRISM) and Department of Mechanical and Aerospace Engineering, Princeton University, Princeton, NJ 08544, USA.
authors.forename: Yifang
authors.initials: Y
authors.lastname: Cao
authors.forename: Randy
authors.initials: R
authors.lastname: Bly
authors.forename: Will
authors.initials: W
authors.lastname: Moore
authors.forename: Zhan
authors.initials: Z
authors.lastname: Gao
authors.forename: Alberto M
authors.initials: AM
authors.lastname: Cuitino
authors.forename: Wole
authors.initials: W
authors.lastname: Soboyejo
mesh_terms: D001696:Biomechanical Phenomena / Q000295:instrumentation / Q000379:methods; D055592:Biophysical Phenomena; D001703:Biophysics; D045744:Cell Line, Tumor; D004548:Elasticity; D020342:Finite Element Analysis; D006801:Humans; D007091:Image Processing, Computer-Assisted; D012516:Osteosarcoma / Q000473:pathology / Q000503:physiopathology*; D013314:Stress, Mechanical; D014783:Viscosity