title: [Survival by a young woman with malnutrition due to alcoholism and eating disorders and with acute respiratory distress syndrome due to severe pneumonia who showed increased serum neutrophil elastase activity].
abstract: A 30-year-old woman with malnutrition due to alcoholism and eating disorders was found to have acute respiratory distress syndrome (ARDS) and sepsis due to severe Streptococcus pneumoniae pneumonia. S. pneumoniae was detected by an in vitro rapid immunochromatographic assay for S. pneumoniae antigen in urine on the day of admission and by blood culture 2 days after admission. Symptoms and laboratory findings improved after treatment with sivelestat sodium hydrate, antibiotics, and mechanical ventilation. Treatment with sivelestat sodium hydrate also decreased serum neutrophil elastase activity. This case demonstrates the usefulness of early treatment with sivelestat sodium hydrate in ARDS due to severe pneumonia.
authors.affiliation: Division of Allergy and Respiratory Diseases, Nara Hospital, Kinki University School of Medicine.
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Nakajima
authors.forename: Hirochiyo
authors.initials: H
authors.lastname: Sawaguchi
authors.forename: Shigenori
authors.initials: S
authors.lastname: Nakajima
mesh_terms: D000328:Adult; D000437:Alcoholism / Q000150:complications*; D001068:Feeding and Eating Disorders / Q000150:complications*; D005260:Female; D005998:Glycine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006801:Humans; D019272:Leukocyte Elastase / Q000097:blood*; D044342:Malnutrition / Q000150:complications* / Q000209:etiology; D011018:Pneumonia, Pneumococcal / Q000150:complications*; D012128:Respiratory Distress Syndrome / Q000188:drug therapy* / Q000209:etiology; D013449:Sulfonamides / Q000627:therapeutic use*
chemical_list: D013449:Sulfonamides; C069195:sivelestat; D019272:Leukocyte Elastase; D005998:Glycine