Development of hepatocellular carcinoma (HCC) in a patient 17 years after recovery from chronic hepatitis B and seroconversion to anti-HBs.
A 63-year-old man was admitted to hospital in 2003 for treatment of a hepatocellular carcinoma (HCC). He was negative for HBs antigen (HBsAg) and anti-HCV antibody, and positive for anti-HBs. He had a past history of chronic hepatitis B. In 1986, HBsAg had become negative with the development of anti-HBs. In 2003, an HCC was detected and liver resection was carried out. Histological examination revealed moderately differentiated HCC and slightly fibrotic liver. It is suggested that a diagnosis of HCC, combined with negativity for HBsAg and anti-HCV antibody, may include cases of past recovery from chronic hepatitis B, such as this case.
Shigematsu
Shuichiro
S
Department of Gastroenterology and Metabology, Ehime Graduate University School of Medicine.
Kumagi
Teru
T
Hiasa
Yoichi
Y
Yoshida
Tomorou
T
Hirooka
Masashi
M
Tokumoto
Yoshio
Y
Matsuura
Bunzo
B
Michitaka
Kojiro
K
Horiike
Norio
N
Tohyama
Taiji
T
Onji
Morikazu
M
D000914:Antibodies, Viral / Q000276:immunology*; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis / Q000209:etiology* / Q000276:immunology; D004198:Disease Susceptibility; D006509:Hepatitis B / Q000276:immunology*; D006515:Hepatitis B virus / Q000276:immunology*; D006801:Humans; D008099:Liver / Q000473:pathology; D008113:Liver Neoplasms / Q000175:diagnosis / Q000209:etiology* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D012307:Risk Factors
D000914:Antibodies, Viral