[Progress in studies of glutathione S-transferase P1 and prostate cancer].
Prostate cancer ( PCa) is an important genitourinary malignancy with increasing morbidity and mortality. Glutathione S-transferase P1 ( GSTP1) , as a phrase- II enzyme, has an important role in the activation and detoxification of carcinogens. There is a close association between GSTP1 gene polymorphisms and the risk of Pca. GSTP1 CpG island hypermethylation can reliably distinguish Pca from benign prostatic hyperplasia( BPH) and promises to be an important molecular marker for the diagnosis of Pca. This paper summarizes the association of GSTP1 with the diagnosis and risk of Pca.
Hou
Gao-feng
GF
Department of Urology, First Hospital, Heilongiiang University of Traditional Chinese Medicine, Harbin, Heilongjiang 150040, China.
Sui
Yong
Y
An
Li-wen
LW
D051549:Glutathione S-Transferase pi / Q000235:genetics; D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000175:diagnosis / Q000209:etiology
C496556:GSTP1 protein, human; D051549:Glutathione S-Transferase pi