title: Recovery from macular phototoxicity after corneal triple procedure.
abstract: OBJECTIVE
  Visual recovery from macular phototoxicity in 2 cases after prolonged exposure to operating microscope light from uncomplicated corneal triple-procedure surgery. Recovery is discussed in the context of repair and regeneration.
  
  
  METHODS
  Retrospective case reports.
  
  
  RESULTS
  Immediately postoperatively, both patients reported positive scotomata and were found to have macular retinal pigment epithelial depigmentation. In 1 case, the fovea was involved. By 6 to 12 months, the scotomata had disappeared despite large areas of retinal pigment epithelial hyperpigmentation remaining.
  
  
  CONCLUSIONS
  Recovery from macular phototoxicity occurs, although the mechanism remains unclear. Positive scotomata in these cases resolved over several months. The time scale of recovery was consistent with the time required for cellular replacement and possible differentiation from neural progenitor cells.
authors.affiliation: Department of Ophthalmology, University of Bristol, Bristol Eye Hospital, Bristol, United Kingdom.
authors.forename: Nathaniel E
authors.initials: NE
authors.lastname: Knox Cartwright
authors.forename: Derek M
authors.initials: DM
authors.lastname: Tole
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Haynes
authors.forename: John J
authors.initials: JJ
authors.lastname: Males
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Dick
authors.forename: Eric J
authors.initials: EJ
authors.lastname: Mayer
mesh_terms: D000368:Aged; D002387:Cataract Extraction; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D015948:Keratoplasty, Penetrating; D019654:Lens Implantation, Intraocular; D008027:Light / Q000009:adverse effects*; D008297:Male; D008853:Microscopy; D008875:Middle Aged; D009885:Ophthalmology / Q000295:instrumentation; D010857:Pigment Epithelium of Eye / Q000503:physiopathology*; D011832:Radiation Injuries / Q000209:etiology / Q000503:physiopathology*; D020127:Recovery of Function; D012160:Retina / Q000503:physiopathology / Q000528:radiation effects*; D012189:Retrospective Studies; D012607:Scotoma / Q000209:etiology / Q000503:physiopathology; D041623:Tomography, Optical Coherence