title: Treatment of experimental peri-implantitis using autogenous bone grafts and platelet-enriched fibrin glue in dogs.
abstract: OBJECTIVE
  The purpose of this study was to evaluate the effects of autogenous bone grafts and platelet-enriched fibrin glue in the treatment of peri-implantitis.
  
  
  METHODS
  Thirty-six screw-type commercially pure titanium implants with rough acid-etched surfaces were inserted into 6 mongrel dogs 3 months after extraction of mandibular premolars. After 3 months of healing, peri-implantitis was induced by placing gauze and wire around the implants. Once peri-implantitis was created, surgical treatments involving a combination of autogenous bone grafts and platelet-enriched fibrin glue, autogenous bone grafts alone, or a conventional flap procedure only (control) were carried out. Six months later, biopsies of the implant sites were taken and prepared for ground sectioning and analysis.
  
  
  RESULTS
  The amount of reosseointegration was significantly higher in peri-implantitis defects treated with combined autogenous bone grafts and platelet-enriched fibrin glue as compared with the other 2 treatment procedures. A mean bone-to-implant contact of 50.1% was obtained in the peri-implantitis lesions treated with combined autogenous bone grafts and platelet-enriched fibrin glue. The corresponding values for the autogenous bone grafts and control groups were 19.3% and 6.5%, respectively.
  
  
  CONCLUSIONS
  The present study demonstrates that surgical treatment involving the combined use of autogenous bone grafts and platelet-enriched fibrin glue might effectively promote reosseointegration in lesions resulting from peri-implantitis.
authors.affiliation: Department of Oral & Maxillofacial Surgery, College of Dentistry, Yonsei University, Seoul and Wonju, South Korea.
authors.forename: Tae-Min
authors.initials: TM
authors.lastname: You
authors.forename: Byung-Ho
authors.initials: BH
authors.lastname: Choi
authors.forename: Shi-Jiang
authors.initials: SJ
authors.lastname: Zhu
authors.forename: Jae-Hyung
authors.initials: JH
authors.lastname: Jung
authors.forename: Seoung-Ho
authors.initials: SH
authors.lastname: Lee
authors.forename: Jin-Young
authors.initials: JY
authors.lastname: Huh
authors.forename: Hyun-Jung
authors.initials: HJ
authors.lastname: Lee
authors.forename: Jingxu
authors.initials: J
authors.lastname: Li
mesh_terms: D016301:Alveolar Bone Loss / Q000601:surgery*; D000818:Animals; D001792:Blood Platelets; D016025:Bone Transplantation / Q000379:methods*; D015921:Dental Implants / Q000009:adverse effects*; D004285:Dogs; D005260:Female; D015718:Fibrin Tissue Adhesive / Q000627:therapeutic use*; D007085:Ilium / Q000637:transplantation; D008336:Mandibular Diseases / Q000601:surgery; D014014:Tissue Adhesives / Q000627:therapeutic use*
chemical_list: D015921:Dental Implants; D015718:Fibrin Tissue Adhesive; D014014:Tissue Adhesives