title: The p53 network: p53 and its downstream genes.
abstract: The tumor-suppressor gene p53 and its downstream genes consist of a complicated gene network. p53 is a key molecular node in the network, which is activated in response to several cellular signals resulting in the maintenance of genetic stability. Several cellular signals may activate the p53 network. When the expression of P53 is elevated, P53-MDM2 module and the ubiquitin system can accurately regulate the expression level of P53. P53 can bind to specific DNA sequence, activate its downstream genes expression, and control cell-cycle arrest, DNA repair, and apoptosis. Elucidating the function of p53 gene network will help understand the interaction mechanisms of p53 and its downstream genes.
authors.affiliation: College of Bioinformation, Chongqing University of Posts and Telecommunications, Chongqing 400065, China. kxshu@yahoo.com.cn
authors.forename: Kun-Xian
authors.initials: KX
authors.lastname: Shu
authors.forename: Biao
authors.initials: B
authors.lastname: Li
authors.forename: Li-Xiang
authors.initials: LX
authors.lastname: Wu
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000502:physiology; D002453:Cell Cycle / Q000502:physiology; D005786:Gene Expression Regulation; D006801:Humans; D051736:Proto-Oncogene Proteins c-mdm2 / Q000378:metabolism; D016159:Tumor Suppressor Protein p53 / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*; D025801:Ubiquitin / Q000378:metabolism
chemical_list: D016159:Tumor Suppressor Protein p53; D025801:Ubiquitin; D051736:Proto-Oncogene Proteins c-mdm2