title: Synthesis of encoded modified oligonucleotide libraries. Part 1: orthogonal chemistry.
abstract: The basis for further development of combinatorial libraries of modified oligonucleotides tagged by a codifying sequence is discussed. The chemistry involved in the orthogonal synthesis of both strands and some representative examples of building blocks are presented.
authors.affiliation: Instituto de Investigaciones en Ingeniería Genética y Biología Molecular, CONICET-UBA, Vuelta de Obligado 2490, Buenos Aires, Argentina.
authors.forename: Paula A
authors.initials: PA
authors.lastname: Sacca
authors.forename: Angelo
authors.initials: A
authors.lastname: Fontana
authors.forename: Javier M
authors.initials: JM
authors.lastname: Montserrat
authors.forename: Adolfo M
authors.initials: AM
authors.lastname: Iribarren
mesh_terms: D002626:Chemistry, Pharmaceutical / Q000379:methods; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D015723:Gene Library; D009841:Oligonucleotides / Q000138:chemical synthesis* / Q000235:genetics
chemical_list: D009841:Oligonucleotides