Global expression profiles in human normal and aneurysmal abdominal aorta based on two distinct whole genome microarray platforms.
Abdominal aortic aneurysms (AAA) are the thirteenth cause of death in the United States. The etiology of the disease is yet largely unknown, although several environmental risk factors (e.g., smoking) have been identified and the search for finding genetic risk factors has been initiated. The purpose of our study was to gain insight into the pathobiology of AAA by determining which genes are expressed in the abdominal aorta under either the diseased or normal states, thereby generating the whole-genome-wide expression profiles for these conditions.
Lenk
Guy M
GM
Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, 3317 Gordon H. Scott Hall of Basic Medical Sciences, 540 E. Canfield Ave., Detroit, MI 48201, USA.
Tromp
Gerard
G
Skunca
Magdalena
M
Gatalica
Zoran
Z
Berguer
Ramon
R
Kuivaniemi
Helena
H
D017544:Aortic Aneurysm, Abdominal / Q000235:genetics*; D015870:Gene Expression / Q000235:genetics*; D020869:Gene Expression Profiling; D015894:Genome, Human / Q000235:genetics*; D006801:Humans; D020411:Oligonucleotide Array Sequence Analysis