title: Effect of anthocyanin-rich extract from black rice (Oryza sativa L. indica) on hyperlipidemia and insulin resistance in fructose-fed rats.
abstract: This study was designed to evaluate the effect of an anthocyanin-rich extract from black rice on hyperlipidemia and insulin resistance in fructose-fed rats. Rats fed fructose diet for 4 weeks exhibited significantly higher plasma insulin levels and lower insulin sensitivity than the control rats fed AIN-93G diet. Dietary supplementation with the anthocyanin-rich extract (5 g/kg of high-fructose diet) prevented the development of fructose-induced insulin resistance. After fructose-induced insulin resistance had been established, 4-week treatment with the anthocyanin-rich extract (5 g/kg of high-fructose diet) or pioglitazone (270 mg/kg of high-fructose diet) ameliorated the glucose intolerance and hyperlipidemia, but the extract failed to reverse the fructose-induced hyperinsulinemia as pioglitazone did. In addition, rats supplemented by the extract exhibited lower oxidative stress than the fructose-fed controls, as indicated by the lower concentrations of plasma thiobarbituric acid reactive substances and blood oxidized glutathione. Overall, these results suggest that the anthocyanin-rich extract from black rice improves certain metabolic abnormalities associated with diets high in fructose.
authors.affiliation: Department of Nutrition, School of Public Health, Sun Yat-sen University (Northern Campus), 74 Zhongshan Road 2, Guangzhou, Guangdong Province, 510080, P. R. China.
authors.forename: Honghui
authors.initials: H
authors.lastname: Guo
authors.forename: Wenhua
authors.initials: W
authors.lastname: Ling
authors.forename: Qing
authors.initials: Q
authors.lastname: Wang
authors.forename: Chi
authors.initials: C
authors.lastname: Liu
authors.forename: Yan
authors.initials: Y
authors.lastname: Hu
authors.forename: Min
authors.initials: M
authors.lastname: Xia
authors.forename: Xiang
authors.initials: X
authors.lastname: Feng
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Xia
mesh_terms: D000818:Animals; D000872:Anthocyanins / Q000627:therapeutic use*; D019540:Area Under Curve; D001786:Blood Glucose / Q000378:metabolism; D005632:Fructose / Q000009:adverse effects; D005978:Glutathione / Q000097:blood / Q000378:metabolism; D006949:Hyperlipidemias / Q000188:drug therapy*; D000960:Hypolipidemic Agents / Q000627:therapeutic use*; D007328:Insulin / Q000378:metabolism; D007333:Insulin Resistance; D008297:Male; D012275:Oryza / Q000737:chemistry*; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D017392:Thiobarbituric Acid Reactive Substances / Q000032:analysis / Q000378:metabolism; D016896:Treatment Outcome
chemical_list: D000872:Anthocyanins; D001786:Blood Glucose; D000960:Hypolipidemic Agents; D007328:Insulin; D010936:Plant Extracts; D017392:Thiobarbituric Acid Reactive Substances; D005632:Fructose; D005978:Glutathione