title: Short communication: detection of quantitative trait loci influencing somatic cell score in Spanish Churra sheep.
abstract: Eleven half-sib ovine families, including 1,421 Spanish Churra ewes, were analyzed for 181 microsatellite markers spanning the entire autosomic ovine genome. Using a multimarker regression method, a daughter experimental design was used to identify putative quantitative trait loci (QTL) affecting the somatic cell score (SCS). Chromosome-wise significance thresholds were set empirically by permuting the phenotypic data. Marker order and genetic distances of the autosomic linkage map built for this commercial population were in accordance with the published ovine linkage map. An across-family association analysis revealed a region on chromosome 20 suggestive of evidence for a QTL. Segregation of the QTL into 2 families was inferred from the within-family analysis, and differences in the position of the suggested QTL were found between the 2 half-sib groups. This could be the result of incomplete information associated with the markers for the significant families. The location of the major histocompatibility complex in proximity to the across-family effect suggests this region may harbor a segregating QTL for the SCS in the Churra population. Studies in dairy cattle examining the SCS have reported linkage associations on corresponding bovine orthologous regions, supporting the validity of our findings.
authors.affiliation: Departamento de Producción Animal, Facultad de Veterinaria, Universidad de León, 24071, León, Spain.
authors.forename: B
authors.initials: B
authors.lastname: Gutiérrez-Gil
authors.forename: M F
authors.initials: MF
authors.lastname: El-Zarei
authors.forename: Y
authors.initials: Y
authors.lastname: Bayón
authors.forename: L
authors.initials: L
authors.lastname: Alvarez
authors.forename: L F
authors.initials: LF
authors.lastname: de la Fuente
authors.forename: F
authors.initials: F
authors.lastname: San Primitivo
authors.forename: J J
authors.initials: JJ
authors.lastname: Arranz
mesh_terms: D000818:Animals; D002452:Cell Count / Q000662:veterinary; D002874:Chromosome Mapping / Q000662:veterinary; D033481:Chromosomes, Mammalian / Q000235:genetics; D005260:Female; D006579:Heterozygote; D008297:Male; D018895:Microsatellite Repeats / Q000235:genetics; D008892:Milk / Q000166:cytology*; D040641:Quantitative Trait Loci; D012756:Sheep / Q000235:genetics*; D013030:Spain