title: Prevalence of primary genotypic resistance in a UK centre: Comparison of primary HIV-1 and newly diagnosed treatment-naive individuals.
abstract: The worrying finding that up to 19% of newly diagnosed HIV-1 cases in the UK have genotypic evidence of transmitted drug-resistant HIV-1 (TrDR-HIV-1) does not concur with levels observed in one London centre. A study of the prevalence of resistance in primary HIV infection and newly diagnosed antiretroviral-naive individuals demonstrated significantly lower levels of TrDR-HIV-1 than previously reported. Variations in the prevalence of TrDR-HIV-1 may reflect the heterogeneity of methodologies and definitions used for resistance.
authors.affiliation: St Mary's Hospital, London, UK.
authors.forename: Julie
authors.initials: J
authors.lastname: Fox
authors.forename: Samantha
authors.initials: S
authors.lastname: Hill
authors.forename: Steve
authors.initials: S
authors.lastname: Kaye
authors.forename: Simon
authors.initials: S
authors.lastname: Dustan
authors.forename: Myra
authors.initials: M
authors.lastname: McClure
authors.forename: Sarah
authors.initials: S
authors.lastname: Fidler
authors.forename: Nicola E
authors.initials: NE
authors.lastname: Mackie
mesh_terms: D000328:Adult; D000368:Aged; D024882:Drug Resistance, Viral / Q000235:genetics*; D005260:Female; D005838:Genotype; D015658:HIV Infections / Q000188:drug therapy / Q000635:transmission / Q000821:virology*; D015497:HIV-1 / Q000187:drug effects* / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged