The association between body size, prostate volume and prostate-specific antigen.
Increasing prostate volume contributes to urinary tract symptoms and may obscure prostate cancer detection. We investigated the association between obesity and prostate volume, prostate-specific antigen (PSA) and PSA density among 753 men referred for prostate biopsy. Among men with a negative biopsy, prostate volume significantly increased approximately 25% from the lowest to highest body mass index (BMI), waist or hip circumference or height categories. PSA was 0.7 ng/ml lower with a high waist-to-hip ratio. These associations were less consistent among subjects diagnosed with high-grade prostatic intraepithelial neoplasia or cancer. Our data suggest that obesity and height are independently associated with prostate volume..
Fowke
J H
JH
Vanderbilt Epidemiology Center, Division of Internal Medicine and Public Health, Vanderbilt University Medical Center, Nashville, TN 37232-8300, USA. jay.fowke@vanderbilt.edu
Motley
S S
SS
Cookson
M S
MS
Concepcion
R
R
Chang
S S
SS
Wills
M L
ML
Smith
J A
JA
D000005:Abdomen / Q000033:anatomy & histology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015992:Body Mass Index; D049628:Body Size; D006801:Humans; D008297:Male; D008875:Middle Aged; D011467:Prostate / Q000033:anatomy & histology*; D017430:Prostate-Specific Antigen / Q000032:analysis*; D011470:Prostatic Hyperplasia / Q000473:pathology*; D049629:Waist-Hip Ratio
D017430:Prostate-Specific Antigen