title: [Comparison of retrograde amnesia changes within different injury levels of cerebral concussion in rats].
abstract: OBJECTIVE
  To investigate the retrograde amnesia changes within different injury levels of cerebral concussion in rats.
  
  
  METHODS
  A metallic pendulum striker device of brain injury was deployed to duplicate CC models of different injury levels within Sprague-Dawley (S-D) rats. The investigated animals were divided into two groups according to classification standard, that is, Pure Cerebral Concussion (PCC) group and Complicated Cerebral Concussion (CCC) group. One control group was used, and each group included 8 animals. The retrograde amnesia of each group was assessed by Morris Water Maze (MWM) Test from 3 days preinjury to 7 days postconcussion.
  
  
  RESULTS
  Compared with the control group, the retrograde amnesia was detected within 3 days in PCC group, and 5 days in CCC group after injury. At the same time, the two groups both manifested space recognition deficit.
  
  
  CONCLUSIONS
  The retrograde amnesia existed in both pure cerebral concussion group and complicated cerebral concussion. Furthermore, the lasting time of retrograde amnesia in animals correlates to the injury level of brain concussion.
authors.affiliation: Department of Forensic Medicine, Kunming Medical College, Kunming, China.
authors.forename: Jian-Xing
authors.initials: JX
authors.lastname: Liu
authors.forename: Jian-Yun
authors.initials: JY
authors.lastname: Yu
authors.forename: Bing-Ying
authors.initials: BY
authors.lastname: Xu
authors.forename: Li-Ping
authors.initials: LP
authors.lastname: Guo
authors.forename: Guang-Ming
authors.initials: GM
authors.lastname: Lan
authors.forename: Xu-Dong
authors.initials: XD
authors.lastname: Zhao
authors.forename: Zhong-Tang
authors.initials: ZT
authors.lastname: Feng
mesh_terms: D000648:Amnesia, Retrograde / Q000209:etiology / Q000523:psychology*; D000818:Animals; D001924:Brain Concussion / Q000150:complications / Q000473:pathology / Q000523:psychology*; D004195:Disease Models, Animal; D005260:Female; D015601:Injury Severity Score; D008297:Male; D018782:Maze Learning; D008568:Memory; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors