Heterochromatin revisited.
The formation of heterochromatin, which requires methylation of histone H3 at lysine 9 and the subsequent recruitment of chromodomain proteins such as heterochromatin protein HP1, serves as a model for the role of histone modifications and chromatin assembly in epigenetic control of the genome. Recent studies in Schizosaccharomyces pombe indicate that heterochromatin serves as a dynamic platform to recruit and spread a myriad of regulatory proteins across extended domains to control various chromosomal processes, including transcription, chromosome segregation and long-range chromatin interactions.
Grewal
Shiv I S
SI
Laboratory of Molecular Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. grewals@mail.nih.gov
Jia
Songtao
S
D000818:Animals; D042002:Chromatin Assembly and Disassembly; D000090266:Chromobox Protein Homolog 5; D002868:Chromosomal Proteins, Non-Histone / Q000235:genetics / Q000378:metabolism; D016798:Ciliophora / Q000235:genetics / Q000378:metabolism; D044127:Epigenesis, Genetic; D006570:Heterochromatin / Q000235:genetics* / Q000378:metabolism*; D006657:Histones / Q000235:genetics / Q000378:metabolism; D008322:Mammals / Q000235:genetics / Q000378:metabolism; D008957:Models, Genetic; D010944:Plants / Q000235:genetics / Q000378:metabolism; D034622:RNA Interference; D012568:Schizosaccharomyces / Q000235:genetics / Q000378:metabolism; D029702:Schizosaccharomyces pombe Proteins / Q000235:genetics / Q000378:metabolism
D002868:Chromosomal Proteins, Non-Histone; D006570:Heterochromatin; D006657:Histones; D029702:Schizosaccharomyces pombe Proteins; D000090266:Chromobox Protein Homolog 5