A review of TRP channels splicing.
Ion channel functional diversity can be achieved at the structural level by means of three main mechanisms: (1) transcriptional regulation and processing of mRNA, (2) heteromerization of different pore-forming channel subunits and (3) incorporation of regulatory subunits to the functional channel complex. In this review article we will focus on one of these mechanisms, alternative pre-mRNA splicing, in the context of the TRP superfamily of cation channels. For this purpose, the basic principles governing pre-mRNA splicing will be introduced and comprehensive tables classifying only published spliced-variants of TRP channels will be presented.
Vázquez
Esther
E
Molecular Physiology and Channelopathies Group, Universitat Pompeu Fabra, Parc de Recerca Biomèdica de Barcelona, C/Dr. Aiguader 80, Barcelona 08003, Spain.
Valverde
Miguel A
MA
D017398:Alternative Splicing; D000818:Animals; D006801:Humans; D020033:Protein Isoforms / Q000096:biosynthesis / Q000235:genetics; D012326:RNA Splicing / Q000502:physiology*; D050052:TRPC Cation Channels / Q000096:biosynthesis / Q000235:genetics*
D020033:Protein Isoforms; D050052:TRPC Cation Channels