Host epigenetic modifications by oncogenic viruses.
Epigenetic alterations represent an important step in the initiation and progression of most human cancers, but it is difficult to differentiate the early cancer causing alterations from later consequences. Oncogenic viruses can induce transformation via expression of only a small number of viral genes. Therefore, the mechanisms by which oncogenic viruses cause cancer may provide clues as to which epigenetic alterations are critical in early carcinogenesis.
Flanagan
J M
JM
CR-UK Viral Oncology Group, Wolfson Institute for Biomedical Research, Gower Street, University College London, London WC1E 6BT, UK. j.flanagan@ucl.ac.uk
D044127:Epigenesis, Genetic; D006801:Humans; D009369:Neoplasms / Q000235:genetics / Q000821:virology*; D014780:Viruses / Q000472:pathogenicity*