title: Bioactive oligostilbenoids from the stem bark of Hopea exalata.
abstract: Hopeanolin (1), an unusual resveratral trimer with an ortho-quinone nucleus, was isolated and characterized from the stem bark of Hopea exalata. Also obtained were six known stibenoids, shoreaphenol (2), vaticanol G (3), alpha-viniferin (4), pauciflorol A (5), vaticanol A (6), and trans-3,5,4'-trihydroxystilbene 2-C-glucoside (7). The structure of 1 was determined by spectroscopic data interpretation. Compounds 1-7 were tested for antifungal activity and inhibitory effects against jack bean urease. Hopeanolin (1) demonstrated antifungal activity in the MIC value range 0.1-22.5 microg/mL.
authors.affiliation: Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, People's Republic of China.
authors.forename: Hui Ming
authors.initials: HM
authors.lastname: Ge
authors.forename: Bo
authors.initials: B
authors.lastname: Huang
authors.forename: Shu Hua
authors.initials: SH
authors.lastname: Tan
authors.forename: Da Hua
authors.initials: da H
authors.lastname: Shi
authors.forename: Yong Chun
authors.initials: YC
authors.lastname: Song
authors.forename: Ren Xiang
authors.initials: RX
authors.lastname: Tan
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D020448:Ericales / Q000737:chemistry*; D007887:Fabaceae / Q000201:enzymology; D006576:Heterocyclic Compounds, 4 or More Rings / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015394:Molecular Structure; D024301:Plant Bark / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D014510:Urease / Q000037:antagonists & inhibitors*
chemical_list: D000935:Antifungal Agents; D004365:Drugs, Chinese Herbal; D006576:Heterocyclic Compounds, 4 or More Rings; C516413:hopeanolin; D014510:Urease