Angiotensin in the kidney: a key to understanding hypertension?
A crosstransplantation study between genetically matched angiotensin AT1 receptor knockout and wild-type mice revealed that renal AT1 receptors are required for the development of angiotensin II-induced hypertension (). However, in this experimental setting, hypertension-related left ventricular hypertrophy seemed to depend on blood pressure elevation rather than on the expression of AT1 receptors in the heart.
Steckelings
Ulrike Muscha
UM
Center for Cardiovascular Research, Institute of Pharmacology, Charité-Universitätsmedizin Berlin, 10115 Berlin, Germany.
Rettig
Rainer
R
Unger
Thomas
T
D000804:Angiotensin II / Q000378:metabolism*; D000818:Animals; D006801:Humans; D006973:Hypertension / Q000378:metabolism*; D017379:Hypertrophy, Left Ventricular / Q000503:physiopathology; D007668:Kidney / Q000378:metabolism*; D016030:Kidney Transplantation; D051379:Mice; D018345:Mice, Knockout; D009206:Myocardium / Q000378:metabolism; D044140:Receptor, Angiotensin, Type 1 / Q000378:metabolism
D044140:Receptor, Angiotensin, Type 1; D000804:Angiotensin II