title: Determination of five nitrobenzoic acids in groundwater by solid-phase extraction and liquid chromatography-mass spectrometry.
abstract: A method involving solid-phase extraction (SPE) and reversed-phase liquid chromatography-mass spectrometry (LC-MS) has been developed for determination, in groundwater, of nitrobenzoic acids associated with 2,4,6-trinitrotoluene production. Pre-concentration on a co-polymer-based SPE cartridge enabled quantitative extraction of the analytes from water. Investigation of negative ion electrospray and atmospheric-pressure chemical ionization mass spectrometry indicated the sensitivity of APCI was more than twice that of ESI. An 15N-labeled internal standard was used to achieve more accurate quantitation and mass assignment. Recovery was better than 80% when 10 mL water was extracted with the SPE cartridge. Combination of SPE with LC-MS analysis resulted in method detection limits of less than 5 microg L-1. The method has been used for analysis of groundwater samples collected from a site of a former ammunition plant. Contamination with nitrobenzoic acids was determined at microg L-1 levels.
authors.affiliation: Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Kowloon, Hong Kong.
authors.forename: Wai-Tang
authors.initials: WT
authors.lastname: Ma
authors.forename: Wan
authors.initials: W
authors.lastname: Chan
authors.forename: Klaus
authors.initials: K
authors.lastname: Steinbach
authors.forename: Zongwei
authors.initials: Z
authors.lastname: Cai