title: Endurance training: an effective and safe treatment for patients with LGMD2I.
abstract: We studied the effect of aerobic training on conditioning in patients with limb-girdle muscular dystrophy type 2I (LGMD2I). Nine patients with LGMD2I cycled fifty 30-minute sessions at 65% of their maximal oxygen uptake over 12 weeks. Training significantly improved work capacity, paralleled by self-reported improvements. Creatine kinase levels did not increase significantly, and muscle morphology was unaffected. Moderate-intensity endurance training is a safe method to increase exercise performance and daily function in patients with LGMD2I.
authors.affiliation: Department of Neurology 2082, Rigshospitalet, Blegdamsvej 9, DK-2100 Copenhagen, Denmark. RH18329@rh.hosp.dk
authors.forename: M-L
authors.initials: ML
authors.lastname: Sveen
authors.forename: T D
authors.initials: TD
authors.lastname: Jeppesen
authors.forename: S
authors.initials: S
authors.lastname: Hauerslev
authors.forename: T O
authors.initials: TO
authors.lastname: Krag
authors.forename: J
authors.initials: J
authors.lastname: Vissing
mesh_terms: D000328:Adult; D015444:Exercise / Q000502:physiology*; D005081:Exercise Therapy / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000473:pathology / Q000502:physiology; D049288:Muscular Dystrophies, Limb-Girdle / Q000473:pathology / Q000628:therapy*; D010807:Physical Endurance / Q000502:physiology*