Impact of donor and recipient factors on allograft survival in lung transplantation: A single-center analysis.
BACKGROUND
It remains unclear which donor and recipient factors influence long-term allograft function in lung transplantation (LTx).


METHODS
From October 1988 to February 2005, a total of 280 recipients underwent LTx at our center. Donor data and cause of death (CoD) were analyzed. The CoD was categorized according to rate of increase in intracranial pressure at the time of death. Each donor and recipient factor was correlated with long-term graft function. Recipient details, type of transplant, indication for transplant, and time on waiting list were analyzed. Recipients were stratified based on allograft ischemia time (AIT): 0 to 6, 6 to 8, 8 to 10, and >10 hours.


RESULTS
Mean donor age was 30.9 years (36.7% male); 49.8% were cytomegalovirus (CMV) positive. Donor CoD was characterized by a slow rise in intracranial pressure (ICP) in 34.4%, rapid ICP in 18.7%, an intermediate ICP in 44.3%, and with no rise in 2.6%. A graft survival benefit was seen with female donors (P = .048); 34.4% of recipients ultimately developed graft failure at long term follow-up. Mean recipient age was 48 years; 63% were male and mean body-mass index (BMI) was 23.6; 60.2% had single lung transplantation, and mean wait list time was 323 days. Mean AIT totaled 421 minutes. Graft survival was longer with AIT of 8 to 10 hours compared to 6 to 8 hours (P = .03).


CONCLUSIONS
Donor factor analysis implied only female donor status conferred a long-term graft survival advantage. Intracranial pressure rise differences appear clinically unimportant. Prolonged cold ischemic time (>10 hours) or low recipient BMI did not adversely affect allograft function in our review.
Lindsey
J D
JD
University of Wisconsin Hospitals, Madison, Wisconsin 53705, USA. jdlindse@wisc.edu
Wigfield
C H
CH
Nath
D S
DS
Anderson
J E
JE
Leverson
G E
GE
Love
R B
RB
D000328:Adult; D002423:Cause of Death; D003586:Cytomegalovirus Infections / Q000453:epidemiology / Q000635:transmission; D005163:Factor Analysis, Statistical; D005260:Female; D006085:Graft Survival / Q000502:physiology*; D006801:Humans; D008171:Lung Diseases / Q000145:classification / Q000601:surgery; D016040:Lung Transplantation / Q000401:mortality / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D016019:Survival Analysis; D014019:Tissue Donors / Q000706:statistics & numerical data*; D014184:Transplantation, Homologous / Q000502:physiology