title: A new S4-ligated zinc-peptide 1:2 complex for the hydrolytic cleavage of DNA.
abstract: A new sulfur-ligated Zn-peptide 1:2 complex, [Zn(II)(Boc-NH-Cys-Gly-Cys-OMe)2]2- (2), was prepared, characterized, and tested for its DNA-binding and -cleavage properties. Complex 2 was found to cleave DNA hydrolytically. The negative charge in 2 reduces the affinity of the complex for DNA, and enhances its binding specificity.
authors.affiliation: Department of Chemistry, Osmania University, Hyderabad-500 007, India. rabi_pr@rediffmail.com
authors.forename: Pulimamidi R
authors.initials: PR
authors.lastname: Reddy
authors.forename: Sepuru K
authors.initials: SK
authors.lastname: Mohan
authors.forename: Pallerla
authors.initials: P
authors.lastname: Manjula
authors.forename: Tushar K
authors.initials: TK
authors.lastname: Chakraborty
mesh_terms: D004247:DNA / Q000032:analysis / Q000737:chemistry* / Q000378:metabolism; D006868:Hydrolysis; D010455:Peptides / Q000032:analysis / Q000737:chemistry* / Q000378:metabolism; D011485:Protein Binding / Q000502:physiology; D015032:Zinc / Q000032:analysis / Q000737:chemistry* / Q000378:metabolism
chemical_list: D010455:Peptides; D004247:DNA; D015032:Zinc