Anaplastic large cell lymphoma with involvement of the pancreas presenting as panniculitis in a patient with a history of acute myeloid leukemia--case report and review of the literature.
A 66-year-old man with history of acute myeloid leukemia (AML) presented with B-symptoms and abdominal pain. A CT scan of the abdomen demonstrated an enlargement of the head and uncinate of pancreas and diffuse lymphadenopathy. The patient developed respiratory distress and expired. An autopsy of the pancreas revealed clusters of large, atypical cells, which morphologically and immunophenotypically were consistent with CD30 positive, ALK-negative anaplastic large cell lymphoma (ALCL) of T-cell lineage and multifocal fat necrosis (panniculitis) in the peripancreatic adipose tissue. This is the first case of ALCL of the pancreas and panniculitis in a patient with history of AML.
Ahmed
Bilal
B
Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USA.
Estey
Elihu
E
Manning
John
J
David
Cynthia
C
Keating
Michael J
MJ
Kantarjian
Hagop
H
Tsimberidou
Apostolia-Maria
AM
D000208:Acute Disease; D000368:Aged; D017809:Fatal Outcome; D006801:Humans; D007951:Leukemia, Myeloid / Q000188:drug therapy*; D017728:Lymphoma, Large-Cell, Anaplastic / Q000737:chemistry / Q000175:diagnosis* / Q000473:pathology; D008297:Male; D009363:Neoplasm Proteins / Q000032:analysis; D016609:Neoplasms, Second Primary / Q000175:diagnosis* / Q000473:pathology; D010179:Pancreas / Q000473:pathology*; D015434:Panniculitis / Q000209:etiology*; D012131:Respiratory Insufficiency / Q000209:etiology
D009363:Neoplasm Proteins