title: On the enigma of pain and hyperalgesia: A molecular perspective.
abstract: Pain is a common symptom of injuries and inflammatory-related conditions. The perception of pain, commonly known as nociception, depends on integrated receptors and molecular pathways. Inflammatory mediators are involved in the genesis, persistence, and severity of pain. Noxious stimuli can trigger a cascade of inflammatory loops that feedback onto sensory modalities and domains of the CNS, in an attempt to alert the brain of deregulated homeostasis. Understanding the mechanisms of pain continue to make nociception and hyperalgesia a burgeoning field of research.
authors.affiliation: Molecular Signaling Research Group, Division of Biological Sciences, Department of Biology and Biomedical Sciences, Faculty of Arts and Sciences, Lebanese International University, Beirut, Lebanon. john.haddad@yahoo.co.uk
authors.forename: John J
authors.initials: JJ
authors.lastname: Haddad
mesh_terms: D000818:Animals; D016207:Cytokines / Q000276:immunology*; D006801:Humans; D006930:Hyperalgesia / Q000150:complications / Q000276:immunology*; D007249:Inflammation / Q000150:complications / Q000276:immunology*; D018836:Inflammation Mediators / Q000276:immunology*; D018448:Models, Immunological; D016328:NF-kappa B / Q000276:immunology*; D010146:Pain / Q000150:complications / Q000276:immunology*
chemical_list: D016207:Cytokines; D018836:Inflammation Mediators; D016328:NF-kappa B