[Preparation of magnetic solid liposome nanoparticles of paclitaxel].
OBJECTIVE
To study a new way to prepare high-dosage paclitaxel entrapped magnetic targeted nanoparticles and evaluate its quality.


METHODS
Fe3O4 nanoparticles are prepared by co-depositing, at the same time ultrasonic is used to decrease soft agglomerate of nanoparticles and increase disperse level of it. The property of nanoparticles surface is improved to make the integrating of liposome and nanoparticle to be tighter. At last, paclitaxel entrapped magnetic solid liposome nanoparticles have been prepared by microemulsion-curing under low-temperature. The loading efficiency and encapsulating rate were determined by reverse-phase high-perfomance chromatography.


RESULTS
The nanoparticles have spherical shape. Diameter of nanoparticle ranged from 150 nm to 170 nm. 98.29% of the drug is entrapped in the particle.


CONCLUSIONS
Magnetic susceptibility of nanoparticles is high, and the nanoparticles meet with the demand of targeted delivery system.
Xin
Sheng-Chang
SC
Department of Pharmacy, General Hospital of Guangzhou Military Command, Guangzhou 510010, China.
Wu
Xin-Rong
XR
Zhou
Li-Zhen
LZ
D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000737:chemistry; D004339:Drug Compounding / Q000379:methods*; D016503:Drug Delivery Systems; D004655:Emulsions; D052203:Ferrosoferric Oxide / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D008081:Liposomes; D053758:Nanoparticles / Q000008:administration & dosage / Q000737:chemistry*; D017239:Paclitaxel / Q000008:administration & dosage / Q000737:chemistry*; D010316:Particle Size; D013696:Temperature; D014465:Ultrasonics
D000972:Antineoplastic Agents, Phytogenic; D004655:Emulsions; D008081:Liposomes; D017239:Paclitaxel; D052203:Ferrosoferric Oxide