title: Artificially engineered magnetic nanoparticles for ultra-sensitive molecular imaging.
abstract: Successful development of ultra-sensitive molecular imaging nanoprobes for the detection of targeted biological objects is a challenging task. Although magnetic nanoprobes have the potential to perform such a role, the results from probes that are currently available have been far from optimal. Here we used artificial engineering approaches to develop innovative magnetic nanoprobes, through a process that involved the systematic evaluation of the magnetic spin, size and type of spinel metal ferrites. These magnetism-engineered iron oxide (MEIO) nanoprobes, when conjugated with antibodies, showed enhanced magnetic resonance imaging (MRI) sensitivity for the detection of cancer markers compared with probes currently available. Also, we successfully visualized small tumors implanted in a mouse. Such high-performance, nanotechnology-based molecular probes could enhance the ability to visualize other biological events critical to diagnostics and therapeutics.
authors.affiliation: Department of Chemistry and Nanomedical National Core Research Center, Yonsei University, Seoul 120-749, Korea.
authors.forename: Jae-Hyun
authors.initials: JH
authors.lastname: Lee
authors.forename: Yong-Min
authors.initials: YM
authors.lastname: Huh
authors.forename: Young-wook
authors.initials: YW
authors.lastname: Jun
authors.forename: Jung-wook
authors.initials: JW
authors.lastname: Seo
authors.forename: Jung-tak
authors.initials: JT
authors.lastname: Jang
authors.forename: Ho-Taek
authors.initials: HT
authors.lastname: Song
authors.forename: Sungjun
authors.initials: S
authors.lastname: Kim
authors.forename: Eun-Jin
authors.initials: EJ
authors.lastname: Cho
authors.forename: Ho-Geun
authors.initials: HG
authors.lastname: Yoon
authors.forename: Jin-Suck
authors.initials: JS
authors.lastname: Suh
authors.forename: Jinwoo
authors.initials: J
authors.lastname: Cheon
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000737:chemistry; D061067:Antibodies, Monoclonal, Humanized; D014408:Biomarkers, Tumor / Q000032:analysis; D002460:Cell Line; D045744:Cell Line, Tumor; D005260:Female; D005290:Ferric Compounds / Q000737:chemistry; D006367:HeLa Cells; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008280:Magnetics; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D053758:Nanoparticles / Q000737:chemistry*; D036103:Nanotechnology / Q000379:methods*; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology; D009374:Neoplasms, Experimental / Q000175:diagnosis / Q000378:metabolism; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000032:analysis / Q000276:immunology; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D000068878:Trastuzumab
chemical_list: D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D014408:Biomarkers, Tumor; D005290:Ferric Compounds; D018719:Erb-b2 Receptor Tyrosine Kinases; D000068878:Trastuzumab; C000499:ferric oxide