Antihypertensive effects of Gynura procumbens extract in spontaneously hypertensive rats.
Aqueous extracts of Gynura procumbens (Lour.) Merr. were orally administered to spontaneously hypertensive (SHR) rats for 4 weeks, and antihypertensive effects were determined. Oral administration of 500 mg/kg of G. procumbens (Lour.) Merr. extract (GPE) resulted in significantly lower blood pressure in SHR rats compared with SHR rats not given GPE (P < .05). Furthermore, GPE-administered rats had significantly lower serum lactate dehydrogenase, creatine phosphate kinase, and increased nitric oxide (NO), a known vasodilator, compared with the non-GPE-administered SHR group (P < .05). These results suggest that oral administration of aqueous GPE may be useful for prevention and treatment of hypertension through increasing NO production in blood vessels.
Kim
Mi-Ja
MJ
Department of Obesity Management, Graduated School of Obesity Science, Dongduk Women's University, Seoul, Republic of Korea.
Lee
Hee Jae
HJ
Wiryowidagdo
Sumali
S
Kim
Hye Kyung
HK
D000818:Animals; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D019659:Asteraceae / Q000737:chemistry*; D001794:Blood Pressure; D003402:Creatine Kinase / Q000097:blood; D006973:Hypertension / Q000188:drug therapy*; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008297:Male; D009569:Nitric Oxide / Q000097:blood; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D051381:Rats; D011918:Rats, Inbred SHR; D013599:Systole
D000959:Antihypertensive Agents; D010936:Plant Extracts; D009569:Nitric Oxide; D007770:L-Lactate Dehydrogenase; D003402:Creatine Kinase