3-Hydroxychromones as cyclin-dependent kinase inhibitors: synthesis and biological evaluation.
A novel series of 3-hydroxychromones were prepared and found to be CDK inhibitors. Isothiazolidine 1,1-dioxide analogues showed potent CDK1 and CDK2 inhibitory activities and inhibited proliferation of EJ, HCT116, SW620, and MDAMB468 cancer cells.
Lee
Jinho
J
Department of Chemistry, Keimyung University, 1000 Sindang-Dong, Dalseo-Gu, Daegu 704-701, South Korea. jinho@kmu.ac.kr
Park
Taesik
T
Jeong
Shinwu
S
Kim
Kyoung-Hee
KH
Hong
Changyong
C
D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D001665:Binding Sites; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D002867:Chromones / Q000138:chemical synthesis* / Q000494:pharmacology*; D051357:Cyclin-Dependent Kinase 2 / Q000037:antagonists & inhibitors; D050756:Cyclin-Dependent Kinase Inhibitor Proteins / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D020128:Inhibitory Concentration 50; D011485:Protein Binding; D013329:Structure-Activity Relationship
C479534:3-hydroxychromone; D000970:Antineoplastic Agents; D002867:Chromones; D050756:Cyclin-Dependent Kinase Inhibitor Proteins; C495894:CDK2 protein, human; D051357:Cyclin-Dependent Kinase 2