title: Highly efficient route to fused polycyclic aromatics via palladium-catalyzed aryne annulation by aryl halides.
abstract: Polycyclic aromatic and heteroaromatic hydrocarbons have been synthesized in high yield by two different processes involving the Pd-catalyzed annulation of arynes. The first process involves a Pd-catalyzed annulation of arynes by 2-halobiaryls and related vinylic halides. The second process utilizes a Pd-catalyzed double annulation of arynes by simple aryl halides. Both processes appear to involve the catalytic, stepwise coupling of two very reactive substrates, an aryne and an organopalladium species, to generate excellent yields of cross-coupled products.
authors.affiliation: Department of Chemistry, Iowa State University, Ames, Iowa 50011, USA.
authors.forename: Zhijian
authors.initials: Z
authors.lastname: Liu
authors.forename: Richard C
authors.initials: RC
authors.lastname: Larock
mesh_terms: D002384:Catalysis; D006219:Halogens / Q000737:chemistry*; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D011083:Polycyclic Compounds / Q000737:chemistry*
chemical_list: D006219:Halogens; D011083:Polycyclic Compounds; D010165:Palladium