Anti-SSA/Ro antibody as a risk factor for fluorouracil-induced drug eruptions showing acral erythema and discoid-lupus-erythematosus-like lesions.
BACKGROUND
It is well known that fluorouracil (FU) agents frequently induce discoid-lupus-erythematosus (DLE)-like eruptions and acral erythema in Japan. However, the etiology of these drug eruptions caused by FU agents has not been clarified yet.


OBJECTIVE
To determine if the existence of anti-SSA/Ro antibody may be a risk factor for FU-agent-induced DLE-like eruptions and acral erythema.


METHODS
Six patients with FU-agent-induced drug eruptions showing DLE-like lesions and acral erythema were enrolled in this study. The titers of anti-SSA/Ro antibody in the sera and the histopathology of the skin lesions were examined.


RESULTS
Biopsy specimens from DLE-like eruptions and all 5 examined acral erythema cases showed lichenoid change of the basal keratinocytes. Direct immunofluorescence studies revealed deposition of immunoglobulins along the basement membrane zone in the lesions of both DLE-like eruptions and acral erythema. Further, all 6 cases had high titers of serum anti-SSA/Ro antibody, which did not decline within 6 months after cessation of the causative drug.


CONCLUSIONS
We propose that anti-SSA/Ro antibody may be a risk factor for FU-agent-induced drug eruptions showing acral erythema and DLE-like eruptions.
Adachi
Atsuko
A
Department of Dermatology, Hyogo Prefectural Kakogawa Hospital, Kakogawa, Japan. adc4954@ybb.ne.jp
Nagai
Hiroshi
H
Horikawa
Tatsuya
T
D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000009:adverse effects*; D001323:Autoantibodies / Q000276:immunology*; D001706:Biopsy; D003937:Diagnosis, Differential; D003875:Drug Eruptions / Q000276:immunology* / Q000473:pathology; D004797:Enzyme-Linked Immunosorbent Assay; D004890:Erythema / Q000175:diagnosis*; D005260:Female; D005472:Fluorouracil / Q000009:adverse effects*; D005500:Follow-Up Studies; D006225:Hand; D006801:Humans; D008179:Lupus Erythematosus, Discoid / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D012261:Ribonucleoproteins / Q000276:immunology*; D000099207:SS-A Antigen
D000964:Antimetabolites, Antineoplastic; D001323:Autoantibodies; D005472:Fluorouracil; D012261:Ribonucleoproteins; D000099207:SS-A Antigen