One-step synthesis of hypoxanthine from glycinamide and diformylurea.
Because of their easy availability and their relative chemical stability, urea, formic acid, and glycine might have played a role in the assembly process of nucleobases. In this paper, a short reaction path is described to prepare hypoxanthine starting from the above mentioned precursors. The formation of hypoxanthine has been verified by high-resolution mass spectrometry with the 15N-labelled urea as starting material, and HPLC analysis. The yield of this condensation reaction has been determined spectrophotometrically.
Lagoja
Irene M
IM
Laboratory of Medicinal Chemistry, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, B-3000 Leuven.
Herdewijn
Piet
P
D005561:Formates / Q000138:chemical synthesis*; D005998:Glycine / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D019271:Hypoxanthine / Q000138:chemical synthesis*; D014508:Urea / Q000138:chemical synthesis*
D005561:Formates; C030544:formic acid; D019271:Hypoxanthine; C018556:glycine amide; D014508:Urea; D005998:Glycine