RNA interference: big applause for silencing in Stockholm.
Eight years ago, Craig Mello, Andrew Fire, and their coworkers provided the first demonstration that double-stranded RNA (dsRNA) triggers the gene-silencing technique that we now call RNA interference (RNAi). For this landmark discovery, Mello and Fire are honored with this year's Nobel Prize in Physiology or Medicine.
Zamore
Phillip D
PD
Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA. phillip.zamore@umassmed.edu
D000818:Animals; D017173:Caenorhabditis elegans / Q000235:genetics; D049673:History, 20th Century; D049674:History, 21st Century; D009613:Nobel Prize; D034622:RNA Interference; D012330:RNA, Double-Stranded; D034741:RNA, Small Interfering / Q000235:genetics; D014481:United States
D012330:RNA, Double-Stranded; D034741:RNA, Small Interfering