Disseminated Mycobacterium tuberculosis infection due to interferon gamma deficiency. Response to replacement therapy.
The case of a previously healthy HIV seronegative woman with disseminated Mycobacterium tuberculosis infection and markedly reduced interferon gamma production is reported here. Complete healing of her disseminated lesions was seen only after addition of subcutaneous interferon gamma to her tuberculosis treatment.
Seneviratne
Suranjith Luke
SL
Clinical Immunology Unit, Queens Medical Centre, Nottingham, UK. suran200@yahoo.co.uk
Doffinger
Rainer
R
Macfarlane
John
J
Ceron-Gutierrez
L
L
Amel Kashipaz
M R
MR
Robbins
A
A
Patel
T
T
Powell
P T
PT
Kumararatne
D S
DS
Powell
Richard J
RJ
D000279:Administration, Cutaneous; D005260:Female; D018023:HIV Seronegativity / Q000276:immunology*; D006801:Humans; D007371:Interferon-gamma / Q000008:administration & dosage / Q000172:deficiency*; D008875:Middle Aged; D009169:Mycobacterium tuberculosis / Q000276:immunology*; D014376:Tuberculosis / Q000188:drug therapy / Q000276:immunology*
D007371:Interferon-gamma