Antispasmodic effects of Persea cordata bark fractions on guinea pig ileum.
The present study describes the antispasmodic activity of some fractions from the bark of Persea cordata, against guinea pig ileum contracted by acetylcholine and histamine. Hexane and dichloromethane fractions demonstrated the most promising biological effects, having similar potency to that of papaverine, a well-known antispasmodic agent.
Cechinel-Filho
Valdir
V
Núcleo de Investigações Químico-Farmacêuticas (NIQFAR)/CCS, Universidade do Vale do Itajaí (UNIVALI), 88302-202, Itajaí, SC, Brazil. cechinel@univali.br
Zampirolo
Júlio A
JA
Stulzer
Hellen K
HK
Schlemper
Valfredo
V
D000109:Acetylcholine; D000818:Animals; D004305:Dose-Response Relationship, Drug; D006168:Guinea Pigs; D006632:Histamine; D007082:Ileum / Q000187:drug effects*; D009119:Muscle Contraction / Q000187:drug effects*; D010276:Parasympatholytics / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D027421:Persea; D008517:Phytotherapy; D024301:Plant Bark; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use
D010276:Parasympatholytics; D010936:Plant Extracts; D006632:Histamine; D000109:Acetylcholine