A novel HLA-DRB1*11 allele, DRB1*1155, was found in a patient through routine DRB1 typing using sequence-specific primers (SSP) and confirmed by allele-specific sequence-based typing.
In comparison with DRB1*1155 allele, DRB1*1103 differs at position 220/221, 'GC' is changed to 'CT', or DRB1*1125 differs at position 210/211, 'AG' is substituted with 'GA'. This results in a single amino acid exchange depending on the closest related allele investigated, whether DRB*1103 codon 74 alanine (GCG) is changed to leucine (CTG) or DRB1*1125 codon 71 arginine (GAG) is replaced with glutamic acid.
Witter
K
K
Labor für Immungenetik, University Munich, Munich, Germany. klaus.witter@med.uni-muenchen.de
Wittmann
G
G
Lehmeier
A M
AM
Albert
T
T
Kauke
T
T
D000483:Alleles; D001483:Base Sequence; D017931:DNA Primers; D005260:Female; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006801:Humans; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D017422:Sequence Analysis, DNA
D017931:DNA Primers; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; C519310:HLA-DRB1*11:55 antigen