title: Angiotensin in the kidney: a key to understanding hypertension?
abstract: A crosstransplantation study between genetically matched angiotensin AT1 receptor knockout and wild-type mice revealed that renal AT1 receptors are required for the development of angiotensin II-induced hypertension (). However, in this experimental setting, hypertension-related left ventricular hypertrophy seemed to depend on blood pressure elevation rather than on the expression of AT1 receptors in the heart.
authors.affiliation: Center for Cardiovascular Research, Institute of Pharmacology, Charité-Universitätsmedizin Berlin, 10115 Berlin, Germany.
authors.forename: Ulrike Muscha
authors.initials: UM
authors.lastname: Steckelings
authors.forename: Rainer
authors.initials: R
authors.lastname: Rettig
authors.forename: Thomas
authors.initials: T
authors.lastname: Unger
mesh_terms: D000804:Angiotensin II / Q000378:metabolism*; D000818:Animals; D006801:Humans; D006973:Hypertension / Q000378:metabolism*; D017379:Hypertrophy, Left Ventricular / Q000503:physiopathology; D007668:Kidney / Q000378:metabolism*; D016030:Kidney Transplantation; D051379:Mice; D018345:Mice, Knockout; D009206:Myocardium / Q000378:metabolism; D044140:Receptor, Angiotensin, Type 1 / Q000378:metabolism
chemical_list: D044140:Receptor, Angiotensin, Type 1; D000804:Angiotensin II