title: Telithromycin inhibits the number of viable bacteria but not lymphocyte accumulation in a murine model of chronic respiratory infection.
abstract: The 14-membered macrolides, such as clarithromycin (CAM) and erythromycin (EM), are effective against diffuse panbronchiolitis. However, there have been no studies on the effects of telithromycin (TEL) on chronic respiratory infection in vivo. In this study, we determined the effect of TEL on an experimental murine model of chronic respiratory infection caused by Pseudomonas aeruginosa with biofilm formation. TEL significantly reduced the number of viable bacteria but had no effect on the proliferation of lymphocytes. In contrast, CAM decreased the number of lymphocytes but had no effect on the number of viable bacteria in the lung. These results suggest that TEL and CAM have different effects on chronic respiratory infection caused by P. aeruginosa.
authors.affiliation: Second Department of Internal Medicine, Nagasaki University Graduate School of Pharmaceutical Sciences, Nagasaki, Japan. kyana-ngs@umin.ac.jp
authors.forename: Katsunori
authors.initials: K
authors.lastname: Yanagihara
authors.forename: Misuzu
authors.initials: M
authors.lastname: Kuroki
authors.forename: Norihide
authors.initials: N
authors.lastname: Higuchi
authors.forename: Hideaki
authors.initials: H
authors.lastname: Ohno
authors.forename: Yasuhito
authors.initials: Y
authors.lastname: Higashiyama
authors.forename: Yoshitsugu
authors.initials: Y
authors.lastname: Miyazaki
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Hirakata
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Mukae
authors.forename: Kazunori
authors.initials: K
authors.lastname: Tomono
authors.forename: Yohei
authors.initials: Y
authors.lastname: Mizuta
authors.forename: Jun-Ichi
authors.initials: J
authors.lastname: Kadota
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Tsukamoto
authors.forename: Shigeru
authors.initials: S
authors.lastname: Kohno
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use; D018441:Biofilms / Q000187:drug effects; D002908:Chronic Disease; D017291:Clarithromycin / Q000494:pharmacology / Q000627:therapeutic use; D004195:Disease Models, Animal; D048628:Ketolides / Q000494:pharmacology* / Q000627:therapeutic use; D008168:Lung / Q000276:immunology; D008214:Lymphocytes / Q000187:drug effects; D008297:Male; D051379:Mice; D011552:Pseudomonas Infections / Q000188:drug therapy*; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000302:isolation & purification; D012141:Respiratory Tract Infections / Q000188:drug therapy* / Q000382:microbiology
chemical_list: D000900:Anti-Bacterial Agents; D048628:Ketolides; D017291:Clarithromycin; C106791:telithromycin