title: Reverse right ventricular remodeling after pulmonary endarterectomy in patients with chronic thromboembolic pulmonary hypertension: utility of magnetic resonance imaging to demonstrate restoration of the right ventricle.
abstract: OBJECTIVE
  Pulmonary arterial hypertension causes right ventricular remodeling; that is, right ventricular dilatation, hypertrophy, and leftward ventricular septal bowing. We studied the effect of pulmonary endarterectomy on the restoration of right ventricular remodeling in patients with chronic thromboembolic pulmonary hypertension by magnetic resonance imaging.
  
  
  METHODS
  In 17 patients with chronic thromboembolic pulmonary hypertension, before and at least 4 months after pulmonary endarterectomy, and in 12 healthy controls, right ventricular and left ventricular end-diastolic and end-systolic volumes (milliliters) and mass (grams per meter squared) and leftward ventricular septal bowing (1 divided by the radius of curvature in centimeters) were determined by magnetic resonance imaging.
  
  
  RESULTS
  Before pulmonary endarterectomy, right ventricular volumes, left ventricular end-diastolic volume, right ventricular mass, and leftward ventricular septal bowing differed significantly between patients with chronic thromboembolic pulmonary hypertension and healthy control subjects. After pulmonary endarterectomy, pulmonary hemodynamics improved, and right and left ventricular volumes and leftward ventricular septal bowing normalized; right ventricular mass decreased significantly (46 +/- 14 to 31 +/- 9 g x m(-2), P< .0005), but did not completely normalize. The change in total pulmonary resistance correlated with the change in right ventricular ejection fraction (r = 0.50, P < .05), right ventricular mass (r = 0.63, P < .01), and leftward ventricular septal bowing (r = 0.50, P < .05).
  
  
  CONCLUSIONS
  Right ventricular remodeling was observed in patients with chronic thromboembolic pulmonary hypertension and restored almost completely after a hemodynamically successful pulmonary endarterectomy. Magnetic resonance imaging is a valuable tool to evaluate cardiac remodeling and function in patients with chronic thromboembolic pulmonary hypertension, both before and after pulmonary endarterectomy.
authors.affiliation: Department of Pulmonology of the Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
authors.forename: Herre J
authors.initials: HJ
authors.lastname: Reesink
authors.forename: J Tim
authors.initials: JT
authors.lastname: Marcus
authors.forename: Igor I
authors.initials: II
authors.lastname: Tulevski
authors.forename: Stuart
authors.initials: S
authors.lastname: Jamieson
authors.forename: Jaap J
authors.initials: JJ
authors.lastname: Kloek
authors.forename: Anton
authors.initials: A
authors.lastname: Vonk Noordegraaf
authors.forename: Paul
authors.initials: P
authors.lastname: Bresser
mesh_terms: D000328:Adult; D000368:Aged; D001794:Blood Pressure; D004691:Endarterectomy; D005260:Female; D006352:Heart Ventricles / Q000473:pathology*; D006801:Humans; D006976:Hypertension, Pulmonary / Q000209:etiology / Q000473:pathology* / Q000503:physiopathology; D019028:Magnetic Resonance Imaging, Cine; D008297:Male; D008875:Middle Aged; D011651:Pulmonary Artery / Q000601:surgery*; D011655:Pulmonary Embolism / Q000150:complications / Q000601:surgery*; D014655:Vascular Resistance; D016276:Ventricular Function; D020257:Ventricular Remodeling