title: Multifocal lamellar keratitis following laser in situ keratomileusis.
abstract: Over a period of approximately 7 months, multiple subepithelial spots were noted in one or both corneas of some patients examined 2 to 6 months after laser in situ keratomileusis (LASIK). The lesions appeared identical to adenovirus keratitis. The eyes were quiet, had good vision, and no patient had a history of adenoviral keratoconjunctivitis. In all eyes, the lesions resolved spontaneously or with topical steroid eyedrops. All investigations were negative for adenovirus. Corneal laser scanning in vivo confocal microscopy revealed Langerhans cells in the epithelium, which disappeared after the lesions resolved.
authors.affiliation: Eye Institute, Auckland, New Zealand. bruce@hadden.co.nz
authors.forename: Osmond Bruce
authors.initials: OB
authors.lastname: Hadden
authors.forename: Dipika
authors.initials: D
authors.lastname: Patel
authors.forename: Trevor Buchanan
authors.initials: TB
authors.lastname: Gray
authors.forename: Antony Trevor
authors.initials: AT
authors.lastname: Morris
authors.forename: Charles Peter
authors.initials: CP
authors.lastname: Ring
mesh_terms: D003318:Corneal Opacity / Q000175:diagnosis / Q000209:etiology*; D003319:Corneal Stroma / Q000473:pathology*; D005469:Fluorometholone / Q000627:therapeutic use; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007634:Keratitis / Q000175:diagnosis / Q000209:etiology*; D020731:Keratomileusis, Laser In Situ / Q000009:adverse effects*; D007801:Langerhans Cells / Q000473:pathology; D018613:Microscopy, Confocal; D009883:Ophthalmic Solutions / Q000627:therapeutic use
chemical_list: D005938:Glucocorticoids; D009883:Ophthalmic Solutions; D005469:Fluorometholone