title: Antitumor-promoting effects of new sesquiterpenes from Crossopetalum tonduzii.
abstract: Seven new sesquiterpenes (1-7) with a 'dihydro-beta-agarofuran' (= 5,11-epoxy-5beta,10alpha-eudesmane) skeleton were isolated from Crossopetalum tonduzii. Their structures were elucidated spectroscopically, especially by means of homo- and heteronuclear NMR correlation (COSY, ROESY, HSQC, and HMBC). The absolute configurations of the new compounds were determined by circular dichroism (CD) studies and by chemical correlations via the derivatives 8-11. The new compounds showed moderate antitumor-promoting effects with respect to the activation of the Epstein-Barr virus early antigen (EBV-EA).
authors.affiliation: Instituto Universitario de Bio-Orgánica Antonio González, Universidad de La Laguna, Avenida Astrofísico Francisco Sánchez 2, La Laguna, 38206 Tenerife.
authors.forename: Cristina R
authors.initials: CR
authors.lastname: Mendoza
authors.forename: Ignacio A
authors.initials: IA
authors.lastname: Jiménez
authors.forename: Harukuni
authors.initials: H
authors.lastname: Tokuda
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kushida
authors.forename: Isabel L
authors.initials: IL
authors.lastname: Bazzocchi
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D029753:Celastraceae / Q000737:chemistry*; D045744:Cell Line, Tumor; D006801:Humans; D015394:Molecular Structure; D012717:Sesquiterpenes / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D012717:Sesquiterpenes