[Effect of L-arginine on antioxidant system and NADH2-depended methemoglobinereductase activity in rat blood].
We investigated the influence of L-arginine, a nitric oxide precursor, on the state of hemoglobin and basic parts of the antioxidant system. We revealed the negative influence of NO hyperproduction on the oxygen transport by haemoglobin, which is manifested by the increase of MetHb concentration and decrease of the MetHb-reductase activity. Also increase of glutathioneperoxidase, glutathionereductase and glutathion-etransferase activities were documentated; at the same time catalase activity in the erythrocyte hemolisate was decreased. This can point on the dominating role of glutathione in the protection of erythrocyte membrane and hemoglobin under the condition of oxidative stress, which was induced by NO hyperproduction.
Skliarov
O Ia
OIa
Fedevych
Iu M
IuM
Melekh
O Ia
OIa
Stadnyk
V V
VV
D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D001120:Arginine / Q000494:pharmacology*; D042966:Cytochrome-B(5) Reductase / Q000097:blood*; D004910:Erythrocyte Membrane / Q000187:drug effects / Q000201:enzymology; D008054:Lipid Peroxides / Q000378:metabolism; D008297:Male; D009097:Multienzyme Complexes / Q000378:metabolism*; D009247:NADH, NADPH Oxidoreductases / Q000378:metabolism*; D009569:Nitric Oxide / Q000378:metabolism*; D020030:Nitric Oxide Donors / Q000494:pharmacology*; D018384:Oxidative Stress / Q000187:drug effects; D051381:Rats
D000975:Antioxidants; D008054:Lipid Peroxides; D009097:Multienzyme Complexes; D020030:Nitric Oxide Donors; D009569:Nitric Oxide; D001120:Arginine; C023107:NADH oxidase; D009247:NADH, NADPH Oxidoreductases; D042966:Cytochrome-B(5) Reductase