Antiherpetic flavones from the heartwood of Artocarpus gomezianus.
The heartwood of Artocarpus gomezianus was investigated for anti-herpetic principles. During the course of the separation, a new compound, artogomezianone (1), was isolated, along with the known compounds cycloartocarpin (2), isocyclomorusin (3), artocarpin (4), norcycloartocarpin (5), norartocarpetin (6), and oxyresveratrol (7). Evaluation of these isolates for inhibitory effects against herpes simplex virus (HSV) types 1 and 2 was carried out using the inactivation method. Compounds 2, 3, 6 and 7 showed moderate activities against both types of HSV, while 1, 4 and 5 were basically inactive.
Likhitwitayawuid
Kittisak
K
Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand. lkittisa@chula.ac.th
Chaiwiriya
Saowalak
S
Sritularak
Boonchoo
B
Lipipun
Vimolmas
V
D000818:Animals; D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D031622:Artocarpus / Q000737:chemistry*; D002522:Chlorocebus aethiops; D047309:Flavones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018259:Herpesvirus 1, Human / Q000187:drug effects* / Q000254:growth & development; D018258:Herpesvirus 2, Human / Q000187:drug effects* / Q000254:growth & development; D015394:Molecular Structure; D014709:Vero Cells; D010948:Viral Plaque Assay
D000998:Antiviral Agents; D047309:Flavones