Preservation of the blood brain barrier integrity may underlie neuroprotective effects of statins in Alzheimer's disease.
Ghribi
Othman
O
Department of Pharmacology, Physiology and Therapeutics, University of North Dakota School of Medicine and Health Sciences, 501 North Columbia Road, Grand Forks, ND 58202, USA. oghribi@medicine.nodak.edu
D000544:Alzheimer Disease / Q000188:drug therapy* / Q000503:physiopathology; D001812:Blood-Brain Barrier / Q000187:drug effects*; D001921:Brain / Q000378:metabolism; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000493:pharmacokinetics / Q000627:therapeutic use*; D006937:Hypercholesterolemia / Q000188:drug therapy; D018696:Neuroprotective Agents / Q000493:pharmacokinetics / Q000627:therapeutic use*; D017035:Pravastatin / Q000493:pharmacokinetics / Q000627:therapeutic use*; D016032:Randomized Controlled Trials as Topic; D019821:Simvastatin / Q000493:pharmacokinetics / Q000627:therapeutic use*
D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D018696:Neuroprotective Agents; D019821:Simvastatin; D017035:Pravastatin