title: Local thrombolytic treatment of cerebral venous thrombosis in three paediatric patients.
abstract: There is increasing evidence that local thrombolysis can be used with relative safety and efficacy in adults with superior sagittal sinus thrombosis (SSST). However, little data is available on the use of local thrombolysis in children with SSST. We report three patients who received local thrombolysis for dural sinus thrombosis. Two patients received urokinase and one patient received urokinase followed by local TPA infusion. Recanalization was achieved in two patients.
authors.affiliation: Department of Neurology, The Aga Khan University, Karachi, Turkey.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Wasay
authors.forename: Rohit
authors.initials: R
authors.lastname: Bakshi
authors.forename: Alper
authors.initials: A
authors.lastname: Dai
authors.forename: Steve
authors.initials: S
authors.lastname: Roach
mesh_terms: D002550:Cerebral Veins / Q000473:pathology*; D002648:Child; D002675:Child, Preschool; D003392:Cranial Sinuses / Q000473:pathology*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D012851:Sinus Thrombosis, Intracranial / Q000188:drug therapy* / Q000473:pathology; D015912:Thrombolytic Therapy; D014568:Urokinase-Type Plasminogen Activator / Q000008:administration & dosage / Q000627:therapeutic use*; D020246:Venous Thrombosis / Q000188:drug therapy* / Q000473:pathology
chemical_list: D014568:Urokinase-Type Plasminogen Activator