Clinical significance of serum angiocidin levels in hepatocellular carcinoma.
Angiocidin, a tumor-secreted protein, was measured in serum of 27 healthy volunteers and 33 hepatocellular carcinoma (HCC) patients. Healthy controls either hepatitis B surface antigen (HBsAg) positive or negative showed undetectable levels. Patients had levels of angiocidin ranging from 15.09 to 195.73 pg/ml. Patients with stages III-IV had higher levels of angiocidin (97+/-13 pg/ml, n=17) compared to those with stages I-II (63+/-37 pg/ml, n=16), p<0.043. Patients with microsatellite tumor nodules had higher average levels (98+/-55 pg/ml, n=17) compared to those without microsatellite nodules (51+/-27 pg/ml, n=20), p<0.032. Our studies suggest that angiocidin predicts advanced stage and intra-hepatic metastasis.
Sabherwal
Yamini
Y
Center for Neurovirology, Department of Neuroscience, Temple University, Philadelphia, PA 19122, USA.
Rothman
Vicki L
VL
Poon
Ronnie T P
RT
Tuszynski
George P
GP
D015153:Blotting, Western; D006528:Carcinoma, Hepatocellular / Q000097:blood / Q000473:pathology*; D002352:Carrier Proteins / Q000097:blood* / Q000378:metabolism / Q000592:standards; D045744:Cell Line, Tumor; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000097:blood / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D046988:Proteasome Endopeptidase Complex; D016601:RNA-Binding Proteins; D012015:Reference Standards
D002352:Carrier Proteins; C498506:PSMD4 protein, human; D016601:RNA-Binding Proteins; D046988:Proteasome Endopeptidase Complex