title: Two new taxoids from Taxus chinensis.
abstract: Two new taxoids, 2,20-O-diacetyltaxumairol N (1) and 14beta-hydroxy-10-deacetyl-2-O-debenzoylbacatin III (2), were isolated from the needles and stems of Taxus chinensis. Their structures were determined on the basis of extensive 1D- and 2D-NMR-spectral analysis. Compound 1 showed weak cytotoxicity activity against T-24 (IC50 = 34 microg/ml) and QGY-7701 (IC50 = 22 microg/ml) cancer lines. Compound 2 showed no obvious cytotoxicity activity against T-24 (IC50 > 100 microg/ml) and QGY-7701 (IC50 > 100 microg/ml) cancer lines.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan 650204, PR China.
authors.forename: Zhi-Hua
authors.initials: ZH
authors.lastname: Xia
authors.forename: Li-Yan
authors.initials: LY
authors.lastname: Peng
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhao
authors.forename: Gang
authors.initials: G
authors.lastname: Xu
authors.forename: Qin-Shi
authors.initials: QS
authors.lastname: Zhao
authors.forename: Han-Dong
authors.initials: HD
authors.lastname: Sun
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D043823:Taxoids / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D020946:Taxus / Q000737:chemistry*
chemical_list: C517883:14-hydroxy-10-deacetyl-2-O-debenzoylbacatin III; C517882:2,20-O-diacetyltaxumairol N; D000972:Antineoplastic Agents, Phytogenic; D043823:Taxoids