Parity, tubal sterilization, hysterectomy and risk of primary fallopian tube carcinoma in Finland, 1975-2004.
We studied the possible relationship among parity, female sterilization, hysterectomy and the risk of primary fallopian tube carcinoma (PFTC) in a case-control study in Finland in cases occurring between 1975 and 2004. A total of 573 PFTC cases were identified from the Finnish Cancer Registry, and 10 age-matched controls per case were randomly selected from the Finnish Central Population Registry. In multivariate analysis (including 189 PFTC cases and 1764 controls) parity was protective: the odds ratio (OR) for 1-2 deliveries was 0.63 (95% CI 0.44-0.91) and for > or =3 deliveries, 0.32 (95% CI 0.19-0.52). The OR for sterilization was 0.74 (95% CI 0.42-1.30) and for hysterectomy 1.27 (95% CI 0.73-2.21). Our findings suggest a possible hormonal background as regards the development of PFTC.
Riska
Annika
A
Department of Obstetrics and Gynaecology, Helsinki University Central Hospital, Haartmaninkatu 2, 00290 Helsinki, Finland. annika.riska@pp.inet.fi
Sund
Reijo
R
Pukkala
Eero
E
Gissler
Mika
M
Leminen
Arto
A
D002277:Carcinoma / Q000453:epidemiology*; D016022:Case-Control Studies; D005185:Fallopian Tube Neoplasms / Q000453:epidemiology*; D005260:Female; D005387:Finland / Q000453:epidemiology; D006801:Humans; D007044:Hysterectomy; D010298:Parity; D011247:Pregnancy; D012307:Risk Factors; D013246:Sterilization, Tubal