Unilateral congenital corneal keloid with anterior segment mesenchymal dysgenesis and subluxated lens: case report and review of literature.
OBJECTIVE
To report the unusual association of unilateral congenital corneal keloid with anterior-segment mesenchymal dysgenesis and bilateral subluxated lens.


METHODS
A 20-year old man presented with a mass lesion involving the left cornea. The corneal lesion had been present since birth. On biomicroscopic examination, a well-defined vascularized, grayish-white mass occupying the whole of the left cornea was seen. The right eye showed multiple peripheral corneal opacities with iridocorneal adhesions, a poorly defined supranasal limbus, and a subluxated lens. Excision biopsy of the mass was done for histopathologic examination.


RESULTS
Histopathologic examination of the excised corneal mass showed features consistent with that of a corneal keloid: thickened keratinized epithelium, absent Bowman membrane layer, and fibrovascular hyperplasia composed of hyalinized collagen fibers with irregular orientation of the collagen lamellae. During penetrating keratoplasty of the left eye, an anomalous iris pattern with poorly defined angle and a supranasal subluxated lens was also observed. Extraction of the subluxated lens was also done. The graft failed subsequent to a nonhealing persistent epithelial defect.


CONCLUSIONS
Our case report highlights the rare association of a unilateral congenital corneal keloid with anterior-segment mesenchymal dysgenesis and bilateral subluxated lens.
Vanathi
M
M
Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India. vanathi_g@yahoo.com
Sen
Seema
S
Panda
Anita
A
Dada
Tanuj
T
Behera
Geeta
G
Khokhar
Sudharshan
S
D000328:Adult; D000869:Anterior Eye Segment / Q000002:abnormalities*; D003316:Corneal Diseases / Q000151:congenital* / Q000601:surgery; D005124:Eye Abnormalities / Q000150:complications* / Q000601:surgery; D006801:Humans; D007627:Keloid / Q000151:congenital* / Q000601:surgery; D015948:Keratoplasty, Penetrating; D007906:Lens Subluxation / Q000150:complications* / Q000601:surgery; D008297:Male; D008648:Mesoderm / Q000473:pathology