Slicer and the argonautes.
Though they started out as somewhat mysterious components of the RNAi effector complexes, Argonaute proteins have since taken center stage in RNAi gene silencing. They interact with small RNAs to effect gene silencing in all RNAi-related pathways known so far. We will review the dramatic advances in our understanding of the role of the Argonautes in RNAi through studies of their structure and function.
Tolia
Niraj H
NH
W.M. Keck Structural Biology Laboratory, Cold Spring Harbor, New York 11724, USA.
Joshua-Tor
Leemor
L
D000595:Amino Acid Sequence; D000818:Animals; D006801:Humans; D008958:Models, Molecular; D010448:Peptide Initiation Factors / Q000737:chemistry / Q000502:physiology*; D017434:Protein Structure, Tertiary; D020027:Pyrococcus furiosus / Q000737:chemistry / Q000502:physiology; D034622:RNA Interference / Q000502:physiology*; D012323:RNA Processing, Post-Transcriptional; D043244:Ribonuclease III / Q000145:classification / Q000502:physiology*; D029702:Schizosaccharomyces pombe Proteins / Q000737:chemistry / Q000502:physiology; D016415:Sequence Alignment; D015398:Signal Transduction
D010448:Peptide Initiation Factors; D029702:Schizosaccharomyces pombe Proteins; D043244:Ribonuclease III