Tandem Staudinger-azaWittig mediated ring expansion: rapid access to new isofagomine-tetrahydroxyazepane hybrids.
New seven-membered iminosugars with potent and selective inhibition towards glycosidases have been prepared as 1-N-iminosugar homologues via a tandem Staudinger-azaWittig mediated ring expansion.
Li
Hongqing
H
Ecole Normale Supérieure, Département de Chimie, UMR 8642, Université Pierre et Marie Curie-Paris 6, 75005 Paris, France.
Zhang
Yongmin
Y
Vogel
Pierre
P
Sinaÿ
Pierre
P
Blériot
Yves
Y
D001381:Azepines / Q000737:chemistry*; D044602:Cellulases / Q000037:antagonists & inhibitors / Q000737:chemistry; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry; D005087:Glucan 1,4-alpha-Glucosidase / Q000037:antagonists & inhibitors / Q000737:chemistry; D006026:Glycoside Hydrolases / Q000037:antagonists & inhibitors / Q000737:chemistry; D050112:Imino Pyranoses / Q000737:chemistry; D050111:Imino Sugars / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010880:Piperidines / Q000737:chemistry*; D043323:alpha-Mannosidase / Q000037:antagonists & inhibitors / Q000737:chemistry
C105399:3,4,5,6-tetrahydroxyazepane; D001381:Azepines; D004791:Enzyme Inhibitors; D050112:Imino Pyranoses; D050111:Imino Sugars; D010880:Piperidines; C098432:isofagomine; D044602:Cellulases; D006026:Glycoside Hydrolases; D043323:alpha-Mannosidase; D005087:Glucan 1,4-alpha-Glucosidase