Evaluation of the progeny of rats treated with topoisomerase II inhibitor vepesid.
Progeny of Wistar rats treated with vepesid 1, 3, and 6 months before mating is characterized by common pathological changes. These changes were more pronounced and more diverse in animals descending from females receiving the cytostatic compared to the progeny of treated males. The severity of toxic effects depended on the period between mating and vepesid treatment. Cytostatic treatment 3 months before mating was associated with minimum toxicity for the progeny.
Borovskaya
T G
TG
Institute of Pharmacology, Tomsk Research Center, Siberian Division, Russian Academy of Medical Sciences. mmu@pharm.tsu.ru
Gol'dberg
V E
VE
Shchemerova
Yu A
YA
Perova
A V
AV
Timina
E A
EA
Pakhomova
A V
AV
D000014:Abnormalities, Drug-Induced; D000818:Animals; D000831:Animals, Newborn; D000972:Antineoplastic Agents, Phytogenic / Q000633:toxicity*; D005047:Etoposide / Q000633:toxicity*; D005260:Female; D005313:Fetal Death / Q000139:chemically induced; D008297:Male; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors; D059005:Topoisomerase II Inhibitors
D000972:Antineoplastic Agents, Phytogenic; D059005:Topoisomerase II Inhibitors; D005047:Etoposide