Customized PEG-derived copolymers for tissue-engineering applications.
PEG-containing copolymers play a prominent role as biomaterials for different applications ranging from drug delivery to tissue engineering. These custom-designed materials offer enormous possibilities to change the overall characteristics of biomaterials by improving their biocompatibility and solubility, as well as their ability to crystallize in polymer blends and to resist protein adsorption. This article demonstrates various principles of PEG-based material design that are applied to fine tune the properties of biomaterials for different tissue engineering applications. More specifically, strategies are described to develop PEG copolymers with various block compositions and specific bulk properties, including low melting points and improved surface hydrophilicity. Highly hydrated polymer gel networks for promoting cellular growth or suppressing protein adsorption and cell adhesion are introduced. By incorporating selectively cleavable cross-links, these hydrophilic polymers can also serve as smart hydrogel scaffolds, mimicking the natural extracellular matrix for cell cultivation and tissue growth. Ultimately, these developments lead to the creation of biomimetic materials to immobilize bioactive compounds, allowing precise control of cellular adhesion and tissue growth. [image: see text]
Tessmar
Joerg K
JK
Department of Pharmaceutical Technology, University of Regensburg, Universitätsstrasse 31, 93040 Regensburg, Germany. joerg.tessmar@chemie.uni-regensburg.de
Göpferich
Achim M
AM
D001672:Biocompatible Materials / Q000737:chemistry*; D040761:Biomimetic Materials; D001704:Biopolymers / Q000737:chemistry*; D005782:Gels; D008968:Molecular Conformation; D011092:Polyethylene Glycols / Q000737:chemistry*; D012995:Solubility; D023822:Tissue Engineering / Q000379:methods* / Q000639:trends; D014867:Water
D001672:Biocompatible Materials; D001704:Biopolymers; D005782:Gels; D014867:Water; D011092:Polyethylene Glycols