title: Non-Hodgkin's lymphoma as an exemplar of the effects of genetics and genomics.
abstract: OBJECTIVE
  To discuss the interface of genetics and genomics science in the identification and management of non-Hodgkin's lymphoma. The field of oncology is an exemplar of how the genomic revolution is influencing more individualized care and treatment of people with cancer and their families.
  
  
  METHODS
  Integrated review of the cancer genetics and genomics literature.
  
  
  METHODS
  Published peer-reviewed research, conference proceedings, and peer-reviewed internet sites regarding the genetics and genomics of cancer and non-Hodgkin's lymphoma were reviewed, analyzed, and data synthesized.
  
  
  RESULTS
  All malignancies have a genetic and genomic basis. Genetic and genomic break-throughs are rapidly being applied to all aspects of cancer care including: (a) identification of at-risk individuals before disease occurs, (b) diagnosis and characterization of disease and its aggressiveness when it appears via gene expression, (c) and individualization of therapies over the disease course based on these new molecular technologies.
  
  
  CONCLUSIONS
  Oncology nurses in every role, clinical subspecialty, and type of education are among the first nurses to integrate genetic and genomic information in such a broad context. This experience shows how genetic and genomic discoveries will interface with other health conditions and ultimately, will affect the practice of all nurses.
authors.affiliation: National Institutes of Health, National Cancer Institute, Center for Cancer Research, Genetics Branch, 8901 Wisconsin Ave., Building 8, RM 5101, Bethesda, MD 20889-5105, USA. calzonek@mail.nih.gov
authors.forename: Kathleen A
authors.initials: KA
authors.lastname: Calzone
authors.forename: Dale Halsey
authors.initials: DH
authors.lastname: Lea
authors.forename: Agnes
authors.initials: A
authors.lastname: Masny
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics; D004273:DNA, Neoplasm / Q000032:analysis; D005820:Genetic Testing; D023281:Genomics; D006801:Humans; D016393:Lymphoma, B-Cell / Q000175:diagnosis / Q000235:genetics* / Q000451:nursing / Q000628:therapy; D016403:Lymphoma, Large B-Cell, Diffuse / Q000175:diagnosis / Q000235:genetics* / Q000451:nursing / Q000628:therapy; D009859:Oncology Nursing; D011110:Polymorphism, Genetic / Q000235:genetics
chemical_list: D014408:Biomarkers, Tumor; D004273:DNA, Neoplasm