title: [Soluble factors with inhibitory activity against type 1 Human Immunodeficiency Virus].
abstract: Soluble factors with inhibitory activity against type 1 Human Immunodeficiency Virus The pathogenesis of HIV-1 infection is a complex process that depends on multiple factors, including viral and host immune and genetic characteristics. This leads to a variable pattern of disease progression among those HIV-1-exposed individuals who become infected, while there are a number of individuals who remain healthy and HIV-1 seronegative despite being serially exposed to HIV-1. These variable outcomes of HIV-1 exposure suggest that there are mechanisms of natural resistance to HIV-1 infection. Although several genetic and adaptive immune mechanisms of resistance have been reported in some exposed seronegative and long-term non-progressor individuals, the mechanisms involved in controlling the establishment and progression of HIV-1 infection are not fully understood. Several soluble factors, such as defensins, chemokines, interferons and ribonucleases, among others, produced by cells of the immune system and epithelial tissues, have a broad anti-viral activity that might play a role as protective mechanisms during HIV-1 exposure. A better understanding of the mechanisms and role of these soluble factors during the natural resistance to HIV-1 infection may have important implications for the design of novel therapeutic strategies to combat the morbidity and mortality associated with the HIV-1 pandemic.
authors.affiliation: Grupo de Inmunovirología-Biogénesis, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia.
authors.forename: Wildeman
authors.initials: W
authors.lastname: Zapata
authors.forename: Carlos Julio
authors.initials: CJ
authors.lastname: Montoya
authors.forename: María Teresa
authors.initials: MT
authors.lastname: Rugeles
mesh_terms: D001685:Biological Factors / Q000276:immunology*; D015658:HIV Infections / Q000453:epidemiology / Q000276:immunology*; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate / Q000502:physiology*
chemical_list: D001685:Biological Factors