Solitary brain metastasis from classic biphasic pulmonary blastoma: a case report and review of the literature.
BACKGROUND
Classic biphasic pulmonary blastoma (CBPB) is a rare and aggressive primary malignancy, brain metastases of this type of tumor are even rarer.


METHODS
A 51-year-old male patient with a solitary cerebral metastasis, diagnosed ten months after left pneumonectomy for a CBPB, was treated by surgery and accelerated hypofractionated radiotherapy.


RESULTS
The patient died 15 months after partial removal of the brain metastasis. Literature review revealed only 4 cases of solitary brain metastases from this type of malignancy. The present case is the second one reported with a combined treatment of surgery and radiotherapy resulting in the longest survival.


CONCLUSIONS
The best treatment for CBPB is difficult to determine because of the small number of cases, however, the combination of surgery with radiotherapy seems to be effective. The effectiveness of chemotherapy has not been ascertained.
Kouvaris
John R
JR
Departement of Radiation Oncology, Aretaieion Hospital, Medical School, University of Athens, Greece. johnkouv@aretaieio.uoa.gr
Gogou
Penelope V
PV
Papacharalampous
Xenofon N
XN
Kostara
Helen J
HJ
Balafouta
Myrsini J
MJ
Vlahos
Lambros J
LJ
D001932:Brain Neoplasms / Q000175:diagnosis* / Q000556:secondary*; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D018202:Pulmonary Blastoma / Q000175:diagnosis* / Q000556:secondary*; D035583:Rare Diseases / Q000175:diagnosis