Double strand DNA cleavage with a binuclear iron complex.
Covalently linking two single strand DNA cleaving agents resulted in a new biomimetic binuclear iron complex capable of effecting oxidative double strand DNA cleavage.
van den Berg
Tieme A
TA
Department of Organic and Molecular Inorganic Chemistry, Stratingh Institute, University of Groningen, Nijenborgh 4, 9747 AG, Groningen, The Netherlands.
Feringa
Ben L
BL
Roelfes
Gerard
G
D004247:DNA / Q000737:chemistry*; D053903:DNA Breaks, Double-Stranded; D053837:DNA Cleavage; D004269:DNA, Bacterial / Q000737:chemistry; D004278:DNA, Superhelical / Q000737:chemistry; D005296:Ferrous Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D007700:Kinetics; D015394:Molecular Structure; D010957:Plasmids / Q000737:chemistry; D011725:Pyridines / Q000138:chemical synthesis / Q000737:chemistry
D004269:DNA, Bacterial; D004278:DNA, Superhelical; D005296:Ferrous Compounds; D011725:Pyridines; D004247:DNA