title: Exercise improves albumin fractional synthetic rate in chronic hemodialysis patients.
abstract: OBJECTIVE
  To determine whether exercise augments the improvements in fractional synthetic rate (FSR) of albumin observed with nutrition alone.
  
  
  METHODS
  Randomized crossover study. Each patient randomly participated in two protein metabolism kinetic studies using primed-constant infusion of (13C) leucine 2 h before, during and 2 h after hemodialysis. Plasma enrichments of (13C) leucine and (13C) ketoisocaproate were examined to determine the FSR of albumin.
  
  
  METHODS
  General Clinical Research Center at Vanderbilt University Medical Center.
  
  
  METHODS
  Five chronic hemodialysis (CHD) patients.
  
  
  METHODS
  Intra-dialytic parenteral nutrition (IDPN) with or without exercise.
  
  
  RESULTS
  Exercise performance during hemodialysis significantly improves the FSR of albumin beyond what is observed with IDPN alone (26.2+/-3.1% per day versus 17.7+/-1.9% per day, P<0.05).
  
  
  CONCLUSIONS
  Exercise improves albumin fractional synthetic rate beyond what is observed with IDPN alone in the acute setting in CHD patients.
authors.affiliation: Department of Medicine, Division of Nephrology, Vanderbilt University School of Medicine, Nashville, TN, USA.
authors.forename: L B
authors.initials: LB
authors.lastname: Pupim
authors.forename: P J
authors.initials: PJ
authors.lastname: Flakoll
authors.forename: T A
authors.initials: TA
authors.lastname: Ikizler
mesh_terms: D000418:Albumins / Q000378:metabolism; D002208:Caproates / Q000493:pharmacokinetics*; D002247:Carbon Isotopes; D018592:Cross-Over Studies; D015444:Exercise / Q000502:physiology*; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000628:therapy*; D007930:Leucine / Q000493:pharmacokinetics*; D008297:Male; D008875:Middle Aged; D010288:Parenteral Nutrition; D006435:Renal Dialysis; D012709:Serum Albumin / Q000032:analysis*
chemical_list: D000418:Albumins; D002208:Caproates; D002247:Carbon Isotopes; D012709:Serum Albumin; D007930:Leucine