title: Determination of gate-on and -off timing in respiration-gated radiotherapy.
abstract: The purpose of this study was to develop an efficient method of determining gate-on and -off timing in respiration-gated radiotherapy. Gate-on and -off timing in a breathing cycle were defined as the respiratory signal level for the start of irradiation (Ls) in the expiration phase and that for the end of irradiation (Le) in the inspiration phase, respectively. Thirty subjects participated in this study. The diaphragm was used as the tracking target, and time-dependent changes in the position of the target were measured together with those in the respiratory signal level. For each subject, the following maps were created by varying the combination of Ls and Le: absolute target displacement (ATD) map, relative target displacement (RTD) map, and gate-on duty cycle (GDC) map. By classifying respiratory signal waveforms, three respiratory types were derived (A: the length of end-expiration level >40% of a breathing cycle, B: the length of end-expiration level <or=40% and that of end-inspiration level >20% of a breathing cycle, and C: the length of end-expiration level <or=40% and that of end-inspiration level <or=20% of a breathing cycle). For each respiratory type, average RTD and GDC maps were created. We presented an algorithm to obtain the optimal Ls and Le using the RTD (or ATD) and GDC maps, and this algorithm was verified by demonstrating that, in determining Ls and Le for a subject, the average RTD and GDC maps corresponding to the subject's respiratory type could be used effectively.
authors.affiliation: Anzai Medical Co., Ltd.
authors.forename: Shigeru
authors.initials: S
authors.lastname: Sase
authors.forename: Takeshi
authors.initials: T
authors.lastname: Sasaki
authors.forename: Hiroyoshi
authors.initials: H
authors.lastname: Fukukita
authors.forename: Takeji
authors.initials: T
authors.lastname: Sakae
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Akine
mesh_terms: D000328:Adult; D000368:Aged; D000465:Algorithms; D003964:Diaphragm / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011881:Radiotherapy, Computer-Assisted / Q000379:methods*; D012119:Respiration; D012143:Respiratory Physiological Phenomena