title: Biotechnological production and bioactivities of mollisin and two new, structurally related fungal naphthoquinone metabolites.
abstract: The antibiotic and fungicidal deuteromycete Mollisia caesia Sacc. was cultivated on a large scale. Mollisin (1; = 8-(dichloroacetyl)-5-hydroxy-2,7-dimethylnaphthalene-1,4-dione) and two new tri- and tetrahalogenated metabolites, mollisin A (2) and mollisin B (3) were isolated from M. caesia. The formation of 2 and 3 indicates that the biosynthesis of these compounds starts from a C(16) polyketide (Scheme). Mollisin (1) shows strong fungicidal activities against Sclerophoma pityophila (Corda) v. Höhn and Heterobasidion annosum (Fr.) Bref., which is one of the most-destructive basidiomycetes in coniferous forests. The metabolites 1-3 possess interesting pharmacological activities in assays in search of anti-inflammatory and antiproliferative drugs.
authors.affiliation: Mycosym Environment GmbH, Andresenstrasse 1a, D-06766 Wolfen.
authors.forename: Siegfried
authors.initials: S
authors.lastname: Johne
authors.forename: Roland
authors.initials: R
authors.lastname: Watzke
authors.forename: Wolfram
authors.initials: W
authors.lastname: Meusel
authors.forename: Ute
authors.initials: U
authors.lastname: Möllmann
authors.forename: Albert
authors.initials: A
authors.lastname: Härtl
authors.forename: Hans-Martin
authors.initials: HM
authors.lastname: Dahse
authors.forename: Burkhard
authors.initials: B
authors.lastname: Matthes
authors.forename: Karlheinz
authors.initials: K
authors.lastname: Seifert
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D045744:Cell Line, Tumor; D006801:Humans; D003904:Mitosporic Fungi / Q000737:chemistry / Q000378:metabolism*; D015394:Molecular Structure; D009285:Naphthoquinones / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology
chemical_list: D000935:Antifungal Agents; D000970:Antineoplastic Agents; D009285:Naphthoquinones; C516791:mollisin A; C516792:mollisin B; C010610:mollisin