title: The persistence of humoral and cellular immunities more than three decades after smallpox vaccination.
abstract: This study assessed the persistence of humoral (neutralising antibody titre to vaccinia virus) and cellular (immediate vaccinia-specific interferon (IFN)-gamma-producing T-cell) immunities to smallpox in a Korean population. Individuals who were vaccinated 25-60 years previously had higher neutralising antibody titres (geometric mean titre (GMT) 13.7; 95% CI 11.0-17.2) than vaccinia-naive individuals (GMT 6.7; 95% CI 5.5-8.0; p <0.001). However, there was no significant difference in cellular immunity between individuals vaccinated previously and vaccinia-naive individuals, and only 15% of the individuals vaccinated previously displayed an immediate IFN-gamma-producing effector-memory response in ELISPOT assays.
authors.affiliation: Center for Infectious Diseases, National Institute of Health, Seoul, Republic of Korea.
authors.forename: S-H
authors.initials: SH
authors.lastname: Kim
authors.forename: S-G
authors.initials: SG
authors.lastname: Yeo
authors.forename: K-H
authors.initials: KH
authors.lastname: Park
authors.forename: J-W
authors.initials: JW
authors.lastname: Bang
authors.forename: H-B
authors.initials: HB
authors.lastname: Kim
authors.forename: N-J
authors.initials: NJ
authors.lastname: Kim
authors.forename: Y
authors.initials: Y
authors.lastname: Jee
authors.forename: H
authors.initials: H
authors.lastname: Cho
authors.forename: M-D
authors.initials: MD
authors.lastname: Oh
authors.forename: K-W
authors.initials: KW
authors.lastname: Choe
mesh_terms: D000328:Adult; D000914:Antibodies, Viral / Q000097:blood*; D005260:Female; D006801:Humans; D007371:Interferon-gamma / Q000096:biosynthesis; D007723:Korea; D008297:Male; D008875:Middle Aged; D009500:Neutralization Tests; D012899:Smallpox / Q000276:immunology* / Q000517:prevention & control; D012900:Smallpox Vaccine / Q000008:administration & dosage / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*; D013997:Time Factors; D014611:Vaccination; D014616:Vaccinia virus / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral; D012900:Smallpox Vaccine; D007371:Interferon-gamma