A pair of novel cytotoxic polyprenylated xanthone epimers from gamboges.
Two new polyprenylated xanthone epimers were isolated from gamboges of Garcinia hanburyi, and identified by detailed spectroscopic analysis as 30-hydroxygambogic acid (2a) and its (2S)-epimer 30-hydroxyepigambogic acid (2b). Both compounds exhibited significant cytotoxicities against the human leukemia K562/S and the corresponding doxorubicin-resistant K562/R cell lines (Table 2).
Han
Quan-Bin
QB
Laboratory of Chinese Medicine, Hong Kong Jockey Club Institute of Chinese Medicine, Hong Kong, PR China.
Yang
Ling
L
Wang
Yu-Lin
YL
Qiao
Chun-Feng
CF
Song
Jing-Zheng
JZ
Sun
Han-Dong
HD
Xu
Hong-Xi
HX
D045744:Cell Line, Tumor; D003603:Cytotoxins / Q000737:chemistry / Q000302:isolation & purification*; D004365:Drugs, Chinese Herbal; D029760:Garcinia; D006801:Humans; D020014:K562 Cells; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification; D044004:Xanthones / Q000737:chemistry / Q000302:isolation & purification*
D003603:Cytotoxins; D004365:Drugs, Chinese Herbal; D010936:Plant Extracts; D044004:Xanthones