Human papillomavirus detection in urine samples: an alternative screening method.
OBJECTIVE
To investigate the usefulness of human papillomavirus detection in the urine of women with poor gynecologic attention.


METHODS
Fifty urine and 50 cervical samples from 50 women were analyzed. Polymerase chain reaction was performed on these 100 samples using consensus primers and a low-density microarray-based method for human papillomavirus typing.


RESULTS
The concordance of the results between both sample groups was 80%. In the urine samples, the sensitivity of polymerase chain reaction for high-grade squamous intraepithelial lesion was 100%, the specificity was 80%, the positive predictive value was 91%, and the negative predictive value was 100%.


CONCLUSIONS
Human papillomavirus detection in urine samples may be used as an alternative screening method for women with poor gynecologic attention.
Alameda
Francesc
F
Department of Pathology, University Hospital del Mar, Autonomous University of Barcelona, Barcelona, Catalonia, Spain. 86780@imas.imim.es
Bellosillo
Beatriz
B
Fusté
Pere
P
Musset
Mercè
M
Mariñoso
Maria-Luisa
ML
Mancebo
Gemma
G
Lopez-Yarto
Maria Teresa
MT
Carreras
Ramon
R
Serrano
Sergi
S
D000328:Adult; D052685:Alphapapillomavirus / Q000302:isolation & purification*; D002584:Cervix Uteri / Q000821:virology; D004279:DNA, Viral / Q000032:analysis / Q000652:urine; D005260:Female; D006801:Humans; D008403:Mass Screening; D008875:Middle Aged; D020411:Oligonucleotide Array Sequence Analysis; D030361:Papillomavirus Infections / Q000175:diagnosis* / Q000652:urine; D016133:Polymerase Chain Reaction; D012680:Sensitivity and Specificity; D014556:Urine / Q000821:virology*; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis* / Q000821:virology; D002578:Uterine Cervical Dysplasia / Q000175:diagnosis* / Q000821:virology
D004279:DNA, Viral