Premorbid exercising in specific cognitive tasks prevents impairment of performance in parkinsonian monkeys.
Adult Cebus apella monkeys were exposed to either one, two or four series of cognitive tasks that place a demand on working memory and inhibitory control (Spatial Delayed Response and Object Retrieval Detour), before administration of the neurotoxin 1-methyl-1-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Following MPTP treatment, monkeys receiving more than one series successfully reached criteria at delays similar to those attained during the pre-MPTP stage for the Spatial Delayed Response task and avoided increased perseveration in the Object Retrieval Detour task. Results provide evidence that protection towards a neurotoxin in specific cognitive performances can be increased by repeated exposure to task-specific cognitive demands and that motor and cognitive impairment following MPTP treatment can be effectively dissociated in primates.
Lipina
Sebastián J
SJ
Unidad de Neurobiología Aplicada (UNA) (CEMIC), Av. Galván 4102 C1431FWO, Buenos Aires, Argentina.
Colombo
Jorge A
JA
D000818:Animals; D001521:Behavior Therapy / Q000379:methods*; D015415:Biomarkers / Q000032:analysis / Q000378:metabolism; D002428:Cebus; D003072:Cognition Disorders / Q000209:etiology / Q000517:prevention & control / Q000628:therapy*; D015928:Cognitive Behavioral Therapy / Q000379:methods*; D018450:Disease Progression; D004298:Dopamine / Q000096:biosynthesis; D007150:Immunohistochemistry; D008297:Male; D009473:Neuronal Plasticity / Q000502:physiology; D009483:Neuropsychological Tests / Q000592:standards*; D020734:Parkinsonian Disorders / Q000150:complications* / Q000503:physiopathology / Q000523:psychology*; D011597:Psychomotor Performance / Q000187:drug effects / Q000502:physiology; D020127:Recovery of Function / Q000502:physiology; D013378:Substantia Nigra / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology; D014446:Tyrosine 3-Monooxygenase / Q000032:analysis / Q000378:metabolism
D015415:Biomarkers; D014446:Tyrosine 3-Monooxygenase; D004298:Dopamine