title: Antihyperglycemic, antistress and nootropic activity of roots of Rubia cordifolia Linn.
abstract: Effect of alcoholic extract of roots of Rubia cordifolia was studied on elevated blood glucose level in alloxan treated animals. The extract reduced the blood sugar level raised by alloxan. Effect of alcoholic extract was also investigated on cold restraint induced stress and on scopolamine-induced memory impairment. Alcoholic extract enhanced brain gamma-amino-n-butyric acid (GABA) levels and decreased brain dopamine and plasma corticosterone levels. Acidity and ulcers caused due to cold restraint stress were inhibited by alcoholic extract. Animals treated with alcoholic extract spent more time in open arm in elevated plus maze model. It also antagonized scopolamine induced learning and memory impairment. Baclofen induced catatonia was potentiated by alcoholic extract.
authors.affiliation: MAEERs Maharashtra Institute of Pharmacy, Kothrud, Pune 411 038, India.
authors.forename: Rupali A
authors.initials: RA
authors.lastname: Patil
authors.forename: Swati C
authors.initials: SC
authors.lastname: Jagdale
authors.forename: Sanjay B
authors.initials: SB
authors.lastname: Kasture
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D003345:Corticosterone / Q000097:blood; D004298:Dopamine / Q000378:metabolism; D005260:Female; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D008297:Male; D051379:Mice; D018697:Nootropic Agents / Q000494:pharmacology*; D010936:Plant Extracts / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry; D045470:Rubia / Q000737:chemistry*; D013312:Stress, Physiological / Q000517:prevention & control*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D018697:Nootropic Agents; D010936:Plant Extracts; D005680:gamma-Aminobutyric Acid; D004298:Dopamine; D003345:Corticosterone