title: Cruentaren, a new antifungal salicylate-type macrolide from Byssovorax cruenta (myxobacteria) with inhibitory effect on mitochondrial ATPase activity. Fermentation and biological properties.
abstract: The novel macrolide cruentaren A was produced at levels up to 3.2 mg/liter by cultures of the myxobacterium Byssovorax cruenta. The new compound strongly inhibited the growth of yeasts and filamentous fungi and showed high cytotoxicity against L929 mouse fibroblast cells. A minor co-metabolite of cruentaren A, named cruentaren B, and identified as a six-membered lactone isomer of cruentaren A, showed only marginal cytotoxicity and no antifungal activity. Cruentaren A inhibited F0F1 mitochondrial ATP-hydrolysis in submitochondrial particles of yeasts and beef heart.
authors.affiliation: Helmholtz Centre for Infection Research, Inhoffenstrasse 7, D-38124 Braunschweig, Germany. brigitte.kunze@helmholtz-hzi.de
authors.forename: Brigitte
authors.initials: B
authors.lastname: Kunze
authors.forename: Heinrich
authors.initials: H
authors.lastname: Steinmetz
authors.forename: Gerhard
authors.initials: G
authors.lastname: Höfle
authors.forename: Markus
authors.initials: M
authors.lastname: Huss
authors.forename: Helmut
authors.initials: H
authors.lastname: Wieczorek
authors.forename: Hans
authors.initials: H
authors.lastname: Reichenbach
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology*; D002417:Cattle; D005285:Fermentation; D005347:Fibroblasts; D005658:Fungi / Q000187:drug effects; D049934:Isocoumarins / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology*; D018942:Macrolides / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology*; D051379:Mice; D008928:Mitochondria / Q000187:drug effects / Q000201:enzymology; D025261:Mitochondrial Proton-Translocating ATPases / Q000037:antagonists & inhibitors*; D015394:Molecular Structure
chemical_list: D000935:Antifungal Agents; D049934:Isocoumarins; D018942:Macrolides; C516694:cruentaren A; C516695:cruentaren B; D025261:Mitochondrial Proton-Translocating ATPases