title: Contribution of oxidative-reductive reactions to high-molecular-weight hyaluronan catabolism.
abstract: Since the content of hyaluronan (HA)-degrading enzymes in synovial fluid (SF), if any, is extremely low, the high rate of HA turnover in SF is to result from a cause different from enzymatic catabolism. An alternative and plausible mechanism is that of oxidative-reductive degradation of HA chains by a combined action of oxygen and transition metal cations maintained in a reduced oxidation state by ascorbate.
authors.affiliation: Institute of Experimental Pharmacology, Slovak Academy of Sciences, Dúbravská cesta 9, SK-84104 Bratislava. ladislav.soltes@savba.sk
authors.forename: Ladislav
authors.initials: L
authors.lastname: Soltés
authors.forename: Monika
authors.initials: M
authors.lastname: Stankovská
authors.forename: Grigorij
authors.initials: G
authors.lastname: Kogan
authors.forename: Peter
authors.initials: P
authors.lastname: Gemeiner
authors.forename: Robert
authors.initials: R
authors.lastname: Stern
mesh_terms: D006820:Hyaluronic Acid / Q000737:chemistry*; D006821:Hyaluronoglucosaminidase / Q000378:metabolism*; D008970:Molecular Weight; D010084:Oxidation-Reduction
chemical_list: D006820:Hyaluronic Acid; D006821:Hyaluronoglucosaminidase