A sensitive gait parameter for quantification of arthritis in rats.
Quantification of arthritis is helpful for investigating pain mechanisms of arthritis and for developing new drugs. We assessed and identified a feasible parameter for quantification of rat arthritis using a novel gait analyzing system. Knee-joint injection with small doses of lambda-carrageenan decreased swing time ratio (STR, swing time of the non-treated hindlimb/swing time of the lambda-carrageenan-injected hindlimb) in a dose-dependent manner. Intraperitoneal treatment with indomethacin restored the decreased STR dose-dependently. The arthritis could not be accurately quantified by swing time and swelling, common indices of arthritis. These results show that STR is a sensitive, reliable parameter for quantification of arthritis.
Orito
Kensuke
K
Department of Veterinary Pharmacology, Azabu University School of Veterinary Medicine, Kanagawa 229-8501, Japan.
Kurozumi
Shogo
S
Ishii
Idaku
I
Tanaka
Akane
A
Sawada
Junko
J
Matsuda
Hiroshi
H
D000818:Animals; D001168:Arthritis / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology; D005684:Gait; D007213:Indomethacin / Q000627:therapeutic use; D008297:Male; D010147:Pain Measurement / Q000379:methods*; D051381:Rats; D017207:Rats, Sprague-Dawley
D007213:Indomethacin