title: Human papillomavirus detection in urine samples: an alternative screening method.
abstract: OBJECTIVE
  To investigate the usefulness of human papillomavirus detection in the urine of women with poor gynecologic attention.
  
  
  METHODS
  Fifty urine and 50 cervical samples from 50 women were analyzed. Polymerase chain reaction was performed on these 100 samples using consensus primers and a low-density microarray-based method for human papillomavirus typing.
  
  
  RESULTS
  The concordance of the results between both sample groups was 80%. In the urine samples, the sensitivity of polymerase chain reaction for high-grade squamous intraepithelial lesion was 100%, the specificity was 80%, the positive predictive value was 91%, and the negative predictive value was 100%.
  
  
  CONCLUSIONS
  Human papillomavirus detection in urine samples may be used as an alternative screening method for women with poor gynecologic attention.
authors.affiliation: Department of Pathology, University Hospital del Mar, Autonomous University of Barcelona, Barcelona, Catalonia, Spain. 86780@imas.imim.es
authors.forename: Francesc
authors.initials: F
authors.lastname: Alameda
authors.forename: Beatriz
authors.initials: B
authors.lastname: Bellosillo
authors.forename: Pere
authors.initials: P
authors.lastname: Fusté
authors.forename: Mercè
authors.initials: M
authors.lastname: Musset
authors.forename: Maria-Luisa
authors.initials: ML
authors.lastname: Mariñoso
authors.forename: Gemma
authors.initials: G
authors.lastname: Mancebo
authors.forename: Maria Teresa
authors.initials: MT
authors.lastname: Lopez-Yarto
authors.forename: Ramon
authors.initials: R
authors.lastname: Carreras
authors.forename: Sergi
authors.initials: S
authors.lastname: Serrano
mesh_terms: D000328:Adult; D052685:Alphapapillomavirus / Q000302:isolation & purification*; D002584:Cervix Uteri / Q000821:virology; D004279:DNA, Viral / Q000032:analysis / Q000652:urine; D005260:Female; D006801:Humans; D008403:Mass Screening; D008875:Middle Aged; D020411:Oligonucleotide Array Sequence Analysis; D030361:Papillomavirus Infections / Q000175:diagnosis* / Q000652:urine; D016133:Polymerase Chain Reaction; D012680:Sensitivity and Specificity; D014556:Urine / Q000821:virology*; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis* / Q000821:virology; D002578:Uterine Cervical Dysplasia / Q000175:diagnosis* / Q000821:virology
chemical_list: D004279:DNA, Viral