The effect of monomers on the formulation of polymeric nanocapsules based on polyureas and polyamides.
Formulation of nanocapsules based on polyureas and polyamides have been tested using a patented process. This method based on polycondensation reaction of two complementary monomers and spontaneous formation of oil in water emulsion, is an alternative concept to the known technique based on the same type of reaction used for the formulation of microcapsules, and in which the lipophilic monomer was emulsified in the organic phase before the formation of the polymeric membrane. Nanocapsules can be prepared from different monomers. Wall based on cross-linked polymer contributes to the stability of nanocapsules during and after formulation. The permeability of the polymeric wall is related to its crystallinity and contributes to the growth of nanocapsule membrane by the diffusion of the hydrophilic monomers to get stable colloidal suspensions.
Montasser
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Université Lyon 1, ISPB, Laboratoire de Génie Pharmacotechnique et Biogalénique, Lyon F-69003, France; CNRS, UMR5007, Laboratoire d'Automatique et de Génie des Procédés, Villeurbanne F-69622, France.
Briançon
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Université Lyon 1, ISPB, Laboratoire de Génie Pharmacotechnique et Biogalénique, Lyon F-69003, France; CNRS, UMR5007, Laboratoire d'Automatique et de Génie des Procédés, Villeurbanne F-69622, France. Electronic address: briancon@lagep.univ-lyon1.fr.
Fessi
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Université Lyon 1, ISPB, Laboratoire de Génie Pharmacotechnique et Biogalénique, Lyon F-69003, France; CNRS, UMR5007, Laboratoire d'Automatique et de Génie des Procédés, Villeurbanne F-69622, France.
D000473:Alkanes / Q000737:chemistry; D002626:Chemistry, Pharmaceutical; D003460:Crystallization; D003485:Cyanates / Q000737:chemistry; D003959:Diamines / Q000737:chemistry; D004337:Drug Carriers; D004339:Drug Compounding; D004655:Emulsions; D005029:Ethylenediamines / Q000737:chemistry; D017953:Isocyanates; D015394:Molecular Structure; D053769:Nanocapsules; D009757:Nylons / Q000737:chemistry*; D009821:Oils / Q000737:chemistry; D010316:Particle Size; D010539:Permeability; D010795:Phthalic Acids / Q000737:chemistry; D011073:Polyamines / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*; D013678:Technology, Pharmaceutical / Q000379:methods*; D014051:Toluene 2,4-Diisocyanate / Q000737:chemistry; D014867:Water / Q000737:chemistry
D000473:Alkanes; D003485:Cyanates; D003959:Diamines; D004337:Drug Carriers; D004655:Emulsions; D005029:Ethylenediamines; D017953:Isocyanates; D053769:Nanocapsules; D009757:Nylons; D009821:Oils; D010795:Phthalic Acids; D011073:Polyamines; D011108:Polymers; C005391:diethylenetriamine; D014867:Water; C015262:1,6-hexamethylene diisocyanate; C061659:sebacoyl chloride; D014051:Toluene 2,4-Diisocyanate; C045786:polyurea; C031234:ethylenediamine; C007297:1,6-diaminohexane