title: Fluoride concentrations in dental plaque and saliva after the use of a fluoride dentifrice preceded by a calcium lactate rinse.
abstract: Plaque fluoride concentrations ([F]) are directly related to plaque calcium concentrations [Ca]. Attempts to increase plaque F uptake from dentifrices or rinses have used methods designed to increase plaque [Ca] but with inconsistent results. This double-blind, double-crossover study tested the effect of a 150 mM calcium lactate rinse used prior to brushing with placebo or fluoridated dentifrices (1030 p.p.m. as NaF) on plaque and salivary [F] and [Ca]. Sixteen children (8-10 yr of age) were randomly assigned to four different groups according to the four treatments (placebo dentifrice or fluoridated dentifrice preceded by calcium lactate or deionized water prerinses). Plaque and saliva were collected 1 and 12 h after brushing on day 7 after starting to use the dentifrices. F was determined using the electrode and Ca was determined using atomic absorption spectrometry. Plaque and salivary [Ca] were not significantly increased after use of the calcium lactate prerinse, except for plaque [Ca] 1 h after the use of the placebo dentifrice. A significant increase in salivary [F] was associated with the calcium lactate prerinse only at 1 h after the use of the fluoridated dentifrice. The the calcium lactate prerinse did not significantly affect plaque [F] under any condition.
authors.affiliation: Department of Pediatric Dentistry, Orthodontics and Public Health, Bauru Dental School, University of São Paulo, Bauru, SP, Brazil.
authors.forename: Juliano P
authors.initials: JP
authors.lastname: Pessan
authors.forename: Cristina M
authors.initials: CM
authors.lastname: Sicca
authors.forename: Tatiana S
authors.initials: TS
authors.lastname: de Souza
authors.forename: Salete M B
authors.initials: SM
authors.lastname: da Silva
authors.forename: Gary M
authors.initials: GM
authors.lastname: Whitford
authors.forename: Marília A R
authors.initials: MA
authors.lastname: Buzalaf
mesh_terms: D002118:Calcium / Q000032:analysis; D017610:Calcium Compounds / Q000493:pharmacokinetics*; D002327:Cariostatic Agents / Q000627:therapeutic use*; D002648:Child; D018592:Cross-Over Studies; D003773:Dental Plaque / Q000737:chemistry / Q000378:metabolism / Q000517:prevention & control*; D003802:Dentifrices / Q000627:therapeutic use*; D004311:Double-Blind Method; D005459:Fluorides / Q000032:analysis; D006801:Humans; D007773:Lactates / Q000493:pharmacokinetics*; D016014:Linear Models; D009067:Mouthwashes / Q000493:pharmacokinetics*; D012463:Saliva / Q000737:chemistry; D012969:Sodium Fluoride / Q000627:therapeutic use*
chemical_list: D017610:Calcium Compounds; D002327:Cariostatic Agents; D003802:Dentifrices; D007773:Lactates; D009067:Mouthwashes; C110051:calcium lactate; D012969:Sodium Fluoride; D005459:Fluorides; D002118:Calcium