title: SUMOylation code in cancer development and metastasis.
abstract: Protein modification by small ubiquitin-like modifier (SUMO) controls diverse cellular functions of protein targets including transcription factors and coregulators mainly in the nucleus and participates in maintaining cellular homeostasis. In addition, SUMO system plays important roles in DNA damage repair and maintaining genome integrity. Thus, in some cases, the loss of control on SUMOylation or deSUMOylation processes causes a defect in maintaining homeostasis and hence gives a cue to cancer development. Furthermore, recent study showed that SUMO system is also involved in cancer metastasis. In this review, we will summarize and discuss the possible role of SUMO system in cancer development and metastasis.
authors.affiliation: Department of Biological Sciences, Research Center for Functional Cellulomics, Seoul National University, Seoul 151-742, Korea. kikim@sookmyung.ac.kr
authors.forename: Keun Il
authors.initials: KI
authors.lastname: Kim
authors.forename: Sung Hee
authors.initials: SH
authors.lastname: Baek
mesh_terms: D000818:Animals; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000378:metabolism* / Q000473:pathology; D011499:Protein Processing, Post-Translational; D025841:Small Ubiquitin-Related Modifier Proteins / Q000378:metabolism*; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism
chemical_list: D025841:Small Ubiquitin-Related Modifier Proteins; D016159:Tumor Suppressor Protein p53