title: Extracts and sesquiterpene derivatives from the red alga Laurencia chondrioides with antibacterial activity against fish and human pathogenic bacteria.
abstract: During screening of seaweeds from different places in Europe for antimicrobial activities against human and fish pathogenic bacteria, Laurencia chondrioides was identified as a promising species. By bioassay-guided isolation, followed by structure elucidation by mass spectrometry and 1H- and 13C-NMR spectrometry, two sesquiterpenoides of the chamigrene-type from the selected red seaweed Laurencia chondrioides were identified. Both compounds inhibit the growth of some fish and human pathogenic bacteria.
authors.affiliation: Institute of Pharmacy, Department of Pharmaceutical Biology, Ernst-Moritz-Arndt University of Greifswald, Jahnstrasse 17, D-17487 Greifswald.
authors.forename: Anne
authors.initials: A
authors.lastname: Bansemir
authors.forename: Natalie
authors.initials: N
authors.lastname: Just
authors.forename: Manfred
authors.initials: M
authors.lastname: Michalik
authors.forename: Ulrike
authors.initials: U
authors.lastname: Lindequist
authors.forename: Michael
authors.initials: M
authors.lastname: Lalk
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects* / Q000472:pathogenicity*; D005393:Fish Diseases / Q000382:microbiology / Q000517:prevention & control; D005399:Fishes / Q000382:microbiology*; D006801:Humans; D044722:Laurencia / Q000737:chemistry* / Q000502:physiology*; D008826:Microbial Sensitivity Tests; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D012717:Sesquiterpenes