Rulers over randomness: stroma cells guide lymphocyte migration in lymph nodes.
How is the amoeboid movement of lymphocytes in secondary lymphoid organs orchestrated? In this issue of Immunity, Bajénoff et al. (2006) demonstrate that stromal cell networks serve as guidance structures that direct and limit the migration of B and T cells in lymph nodes.
Mempel
Thorsten R
TR
Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA.
Junt
Tobias
T
von Andrian
Ulrich H
UH
D000818:Animals; D002634:Chemotaxis, Leukocyte / Q000276:immunology*; D006801:Humans; D008198:Lymph Nodes / Q000276:immunology*; D008214:Lymphocytes / Q000276:immunology*; D018448:Models, Immunological; D017154:Stromal Cells / Q000276:immunology*