Thermosensitive Y-shaped micelles of poly(oleic acid-Y-N-isopropylacrylamide) for drug delivery.
A novel thermosensitive amphiphilic copolymer comprised of two hydrophobic poly(oleic acid) (POA) segments and one hydrophilic poly(N-isopropylacrylamide) (PNIPAAm) segment was designed and synthesized. The structure of the copolymer was confirmed as Y-shaped by FTIR, 1H NMR, and SEC-MALLS analysis. A cytotoxicity study shows that the P(OA-Y-NIPAAm) copolymer exhibits good biocompatibility. The copolymer may self-assemble into micelles in water, with the hydrophobic POA segments at the cores of micelles and the hydrophilic PNIPAAm segments as the outer shells. The resulting micelles demonstrate temperature sensitivity with a lower critical solution temperature (LCST) of 31.5 degrees C and a critical micelle concentration (CMC) of 12.6 mg L(-1). Transmission electron microscopy (TEM) shows that the micelles exhibit a nanospheric morphology within a narrow size range of approximately 10-30 nm. A study of controlled release reveals that the self-assembled micelles have great potential as drug carriers.
Li
Yong-Yong
YY
Key Laboratory of Biomedical Polymers of the Ministry of Education and Department of Chemistry, Wuhan University, Wuhan 430072, PR China.
Zhang
Xian-Zheng
XZ
Kim
Gwang-Chol
GC
Cheng
Han
H
Cheng
Si-Xue
SX
Zhuo
Ren-Xi
RX
D016475:3T3 Cells; D000180:Acrylic Resins / Q000633:toxicity; D000818:Animals; D001672:Biocompatible Materials; D003692:Delayed-Action Preparations; D016503:Drug Delivery Systems; D006358:Hot Temperature; D051379:Mice; D008823:Micelles; D019301:Oleic Acid / Q000633:toxicity; D000099166:Polyacrylamides
D000180:Acrylic Resins; D001672:Biocompatible Materials; D003692:Delayed-Action Preparations; D008823:Micelles; D019301:Oleic Acid; D000099166:Polyacrylamides