HOW to wrap axons with crooked neck.
How can RNA processing direct specific aspects of nervous system development? In this issue of Neuron, Edenfeld et al. identified a novel function for two regulators of mRNA splicing in Drosophila: peripheral glial cells require Crooked neck (Crn) and Held out wings (HOW) to mediate migration and ensheathment of peripheral axons.
Salecker
Iris
I
MRC National Institute for Medical Research, Division of Molecular Neurobiology, The Ridgeway, London NW7 1AA, United Kingdom.
D000818:Animals; D001369:Axons / Q000378:metabolism*; D004330:Drosophila; D029721:Drosophila Proteins / Q000502:physiology*; D009457:Neuroglia / Q000502:physiology; D009687:Nuclear Proteins / Q000502:physiology*; D012326:RNA Splicing / Q000502:physiology; D016601:RNA-Binding Proteins / Q000502:physiology*
D029721:Drosophila Proteins; D009687:Nuclear Proteins; D016601:RNA-Binding Proteins; C069204:crn protein, Drosophila; C106296:how protein, Drosophila