Nucleolipids: natural occurrence, synthesis, molecular recognition, and supramolecular assemblies as potential precursors of life and bioorganic materials.
Nucleolipids are hybrid molecules composed of a nucleobase, a nucleoside, a nucleotide or an oligonucleotide (either DNA or RNA), and a lipophilic moiety, which might be either simply a single- or double-chained alkyl (or alkenyl) moiety or a carbocyclic hydrocarbon such as cholesterol, a vitamin, or a bile acid. This review covers all aspects of nucleolipids, namely their natural occurrence, their synthesis, their molecular recognition, as well as aggregation behavior, either in aqueous or non-aqueous solution. Potential future aspects of nucleolipids in material sciences and for the elucidation of biochemical reactions in living cells are discussed.
Rosemeyer
Helmut
H
Katholieke Universiteit Leuven, Dept. Farmaceutische Wetenschappen, Afd. Medicinale Chemie, Minderbroederstraat 10, B-3000 Leuven. helmut.rosemeyer@rega.kuleuven.ac.be
D000900:Anti-Bacterial Agents / Q000737:chemistry; D008055:Lipids / Q000737:chemistry*; D009705:Nucleosides / Q000737:chemistry*; D009711:Nucleotides / Q000737:chemistry*
D000900:Anti-Bacterial Agents; D008055:Lipids; D009705:Nucleosides; D009711:Nucleotides