title: Effect of GABAergic and adrenergic agents on activity of Na+/K+ pump and Cl(-)-cotransport in somatic muscle cells of earthworm Lumbricus Terrestris.
abstract: GABA, baclofen, epinephrine, and norepinephrine hyperpolarized the membrane of earthworm somatic cells. This effect was prevented by furosemide, removal of Cl- from the medium, or activation of Na+/K+ pump by 3-fold increase external potassium concentration. It was hypothesized that GABA, baclofen, epinephrine, and norepinephrine stimulate Na+/K+ transport via specific receptor inputs, but their effect on resting potential can be realized only under conditions of working Cl- symport.
authors.affiliation: Kazan State Medical University. emvolkov@kzn.ru
authors.forename: E M
authors.initials: EM
authors.lastname: Volkov
authors.forename: A R
authors.initials: AR
authors.lastname: Sabirova
authors.forename: L F
authors.initials: LF
authors.lastname: Nurullin
authors.forename: S N
authors.initials: SN
authors.lastname: Grishin
authors.forename: A L
authors.initials: AL
authors.lastname: Zefirov
mesh_terms: D018663:Adrenergic Agents / Q000494:pharmacology*; D000818:Animals; D018682:GABA Agents / Q000494:pharmacology*; D008564:Membrane Potentials / Q000187:drug effects*; D009132:Muscles / Q000187:drug effects* / Q000378:metabolism; D009835:Oligochaeta / Q000378:metabolism*; D049992:Sodium Chloride Symporters / Q000378:metabolism*; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*
chemical_list: D018663:Adrenergic Agents; D018682:GABA Agents; D049992:Sodium Chloride Symporters; D000254:Sodium-Potassium-Exchanging ATPase