Transgenic probiotica as drug delivery systems: the golden bullet?
Functional human proteins are constitutively produced in genetically modified bacteria that survive on human mucosal surfaces, to the benefit of the host. The successful Phase I clinical trial with IL-10-producing Lactococcus lactis for Crohn's disease has opened new avenues for the use of transgenic bacteria as delivery vehicles. The major advantage of this novel strategy is the avoidance of systemic side effects associated with conventional therapies. This methodology opens up an alternative method for local delivery of therapeutic proteins to various mucosal tissues.
Yuvaraj
Saravanan
S
Peppelenbosch
Maikel P
MP
Bos
Nicolaas A
NA
D017321:Clinical Trials, Phase I as Topic; D003424:Crohn Disease / Q000628:therapy; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D016753:Interleukin-10 / Q000096:biosynthesis / Q000235:genetics*; D013294:Lactococcus lactis / Q000235:genetics* / Q000378:metabolism / Q000502:physiology; D019936:Probiotics / Q000008:administration & dosage*; D011994:Recombinant Proteins / Q000096:biosynthesis
D011994:Recombinant Proteins; D016753:Interleukin-10