title: Curative endoscopic resection of early esophageal adenocarcinomas (Barrett's cancer).
abstract: BACKGROUND
  In view of the increasing incidence of adenocarcinoma in Barrett's esophagus and the mortality and high morbidity rates associated with surgical therapy for this condition, safe and effective but less invasive methods of treatment are needed.
  
  
  OBJECTIVE
  To evaluate efficacy and safety of endoscopic resection in these patients.
  
  
  METHODS
  Single-center prospective study.
  
  
  METHODS
  Teaching hospital, conducted between October 1996 and September 2003.
  
  
  METHODS
  A total of 100 consecutive patients (mean age, 62.1 +/- 10.9 years; range, 31-86 years) with low-risk adenocarcinoma of the esophagus (macroscopic types I, IIa, IIb, and IIc; lesion diameter up to 20 mm; mucosal lesion without invasion into lymph vessels and veins; and histologic grades G1 and G2) arising in Barrett's metaplasia.
  
  
  METHODS
  Endoscopic resection with the suck-and-cut technique.
  
  
  METHODS
  Complete local remission.
  
  
  RESULTS
  A total of 144 resections (1.47 per patient) were performed without technical problems. No major complications and only 11 minor ones (bleedings without decrease of Hb >2 g/dL; treated with injection therapy) occurred. Complete local remission was achieved in 99 of the 100 patients after 1.9 months (range, 1-18 months) and a maximum of 3 resections. During a mean follow-up period of 36.7 months, recurrent or metachronous carcinomas were found in 11% of the patients, but successful repeat treatment with endoscopic resection was possible in all of these cases. The calculated 5-year survival rate was 98%. Two patients died of other causes.
  
  
  CONCLUSIONS
  Nonblinded, nonrandomized study.
  
  
  CONCLUSIONS
  Endoscopic resection is associated with favorable outcomes for low-risk patients with early esophageal adenocarcinoma (Barrett's carcinoma).
authors.affiliation: Department of Internal Medicine II, HSK Wiesbaden, Teaching Hospital of the University of Mainz, Wiesbaden, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Ell
authors.forename: Andrea
authors.initials: A
authors.lastname: May
authors.forename: Oliver
authors.initials: O
authors.lastname: Pech
authors.forename: Liebwin
authors.initials: L
authors.lastname: Gossner
authors.forename: Erwin
authors.initials: E
authors.lastname: Guenter
authors.forename: Angelika
authors.initials: A
authors.lastname: Behrens
authors.forename: Lars
authors.initials: L
authors.lastname: Nachbar
authors.forename: Josephus
authors.initials: J
authors.lastname: Huijsmans
authors.forename: Michael
authors.initials: M
authors.lastname: Vieth
authors.forename: Manfred
authors.initials: M
authors.lastname: Stolte
mesh_terms: D000230:Adenocarcinoma / Q000000981:diagnostic imaging / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D000368:Aged; D001471:Barrett Esophagus / Q000000981:diagnostic imaging / Q000401:mortality / Q000473:pathology / Q000517:prevention & control / Q000601:surgery*; D016099:Endoscopy, Gastrointestinal / Q000379:methods; D019160:Endosonography; D004938:Esophageal Neoplasms / Q000000981:diagnostic imaging / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D015993:Life Tables; D008297:Male; D008875:Middle Aged; D009092:Mucous Membrane / Q000601:surgery; D011446:Prospective Studies; D054328:Proton Pump Inhibitors; D016896:Treatment Outcome
chemical_list: D054328:Proton Pump Inhibitors