title: [Structure-functional changes in the rat pancreas after glucose injection].
abstract: Electron microscopic method was used to study the effect of hyperglycemia on the pancreas of albino rats (n = 20) after intraperitoneal administration of 40% glucose solution (daily, for 5 days). The data obtained suggest that repeated administration of glucose was accompanied by marked changes in the structure B-endocrinocytes, indicative of the increased secretion of the insulin. This resulted in the appearance of new small pancreatic islets, that consisted of B-endocrinocytes and acino-insular cells. Most frequently acinar-insular cells were located at the periphery of newly formed islets. The latter often had a symplast-type structural organization.
authors.forename: V F
authors.initials: VF
authors.lastname: Ivanova
authors.forename: A A
authors.initials: AA
authors.lastname: Puzyrev
mesh_terms: D000818:Animals; D005947:Glucose / Q000633:toxicity; D006943:Hyperglycemia / Q000139:chemically induced / Q000473:pathology*; D007274:Injections, Intraperitoneal; D007515:Islets of Langerhans / Q000473:pathology / Q000648:ultrastructure; D008297:Male; D046529:Microscopy, Electron, Transmission; D010179:Pancreas / Q000473:pathology*; D051381:Rats
chemical_list: D005947:Glucose