title: In situ immune response in brain and kidney during early relapsing fever borreliosis.
abstract: Characterization of the host immune response during initial pathogenesis of relapsing fever neuroborreliosis would be a key to understanding Borrelia persistence and factors driving the inflammatory process. We analyzed immune cells in brain and kidney with the highly invasive B. crocidurae during the first two weeks of murine infection. In both organs, microglia and/or macrophages predominated while T-cell changes were minimal. Compared to kidney, brain neutrophils infiltrated more rapidly and B-cells were essentially absent. Our results indicate that during early neuroborreliosis, brain defense is comprised primarily of innate immune cells while adaptive immunity plays a minor role.
authors.affiliation: Umeå University, Department of Molecular Biology, SE-90187 Umeå, Sweden.
authors.forename: Marie
authors.initials: M
authors.lastname: Andersson
authors.forename: Annika
authors.initials: A
authors.lastname: Nordstrand
authors.forename: Alireza
authors.initials: A
authors.lastname: Shamaei-Tousi
authors.forename: Anna
authors.initials: A
authors.lastname: Jansson
authors.forename: Sven
authors.initials: S
authors.lastname: Bergström
authors.forename: Betty P
authors.initials: BP
authors.lastname: Guo
mesh_terms: D000818:Animals; D000943:Antigens, Differentiation / Q000378:metabolism; D001899:Borrelia Infections / Q000150:complications* / Q000276:immunology; D001921:Brain / Q000276:immunology*; D007150:Immunohistochemistry / Q000379:methods; D007668:Kidney / Q000276:immunology*; D008264:Macrophages / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D019581:Neuropil / Q000378:metabolism; D012061:Relapsing Fever / Q000209:etiology* / Q000276:immunology*; D013144:Spirochaetales / Q000302:isolation & purification; D013997:Time Factors
chemical_list: D000943:Antigens, Differentiation