title: [A case of primary small cell carcinoma arising from the common bile duct].
abstract: Small cell carcinoma is usually seen in the lung, but rarely involves the gastrointestinal tract including biliary tract. A 65 year-old man was admitted because of obstructive jaundice. A smooth-surfaced round intraluminal mass with proximal bile duct dilatation was seen in the proximal common bile duct on endoscopic retrograde cholangiogram. Under the diagnosis of bile duct cancer, pylorus-preserving pancreatoduodenectomy was done. Pathology revealed a 2 cm sized small cell carcinoma in the proximal common bile duct and distal common hepatic duct. On immunohistochemical stain, the tumor cells were positive for neuroendocrine markers CD56 and synaptophysin. After surgery, the patient received 5 cycles of adjuvant chemotherapy with VIP (etoposide, ifosfamide, and cisplatin) regimen. However, the patient died of liver metastasis 12 months after the diagnosis. We report a case of extrapulmonary small cell carcinoma arising from the common bile duct.
authors.affiliation: Department of Internal Medicine, and Pathology, Chungbuk National University, College of Medicine and Medical Research Institute, Heungdeok-Gu, Cheongju, Korea.
authors.forename: Won Joong
authors.initials: WJ
authors.lastname: Jeon
authors.forename: Hee Bok
authors.initials: HB
authors.lastname: Chae
authors.forename: Seon Mee
authors.initials: SM
authors.lastname: Park
authors.forename: Sei Jin
authors.initials: SJ
authors.lastname: Youn
authors.forename: Jae Woon
authors.initials: JW
authors.lastname: Choi
authors.forename: Seok Hyoung
authors.initials: SH
authors.lastname: Kim
mesh_terms: D000368:Aged; D001650:Bile Duct Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000601:surgery; D018288:Carcinoma, Small Cell / Q000150:complications / Q000175:diagnosis* / Q000601:surgery; D002760:Cholangiopancreatography, Endoscopic Retrograde; D003135:Common Bile Duct / Q000000981:diagnostic imaging / Q000601:surgery; D017809:Fatal Outcome; D006801:Humans; D008113:Liver Neoplasms / Q000175:diagnosis / Q000556:secondary; D008297:Male; D049268:Positron-Emission Tomography; D014057:Tomography, X-Ray Computed