In vitro potentiation of antimalarial activities by daphnetin derivatives against Plasmodium falciparum.
OBJECTIVE
To screen the antimalarial compounds of daphnetin derivatives against Plasmodium falciparum in vitro.


METHODS
Plasmodium faciparum (FCC1) was cultured in vitro by a modified method of Trager and Jensen. Antimalarial compounds were screened by microscopy-based assay and microfluorimetric method.


RESULTS
DA79 and DA78 showed potent antimalarial activity against Plasmodium falciparum cultured in vitro.


CONCLUSIONS
Though the relationship between the structures of daphnetin derivatives and their antimalarial activities has not been clarified yet, this study may provide a new direction for discovery of more potential antimalarial compounds.
Huang
Fang
F
National Institute of Parasite Diseases, Chinese Center for Disease Control and Prevention, Shanghai 200025, China. huangfang78@yahoo.com.cn
Tang
Lin-Hua
LH
Yu
Lin-Qian
LQ
Ni
Yi-Chang
YC
Wang
Qin-Mei
QM
Nan
Fa-Jun
FJ
D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000493:pharmacokinetics* / Q000494:pharmacology; D010963:Plasmodium falciparum / Q000187:drug effects*; D014468:Umbelliferones / Q000737:chemistry / Q000493:pharmacokinetics* / Q000494:pharmacology
D000962:Antimalarials; D014468:Umbelliferones; C039952:daphnetin