title: Iron-deficiency anemia as presentation of pouchitis.
abstract: OBJECTIVE
  This study sought to describe the percentage and cause of anemia in patients who underwent ileal pouch with anal anastomosis (IPAA) for ulcerative colitis (UC), and to compare the distribution of complications in patients with and without anemia, especially pouchitis, after IPAA.
  
  
  BACKGROUND
  IPAA is the surgical procedure of choice for UC. Complications include pouchitis (40%), strictures (30%), small bowel obstruction (10%), pelvic sepsis (<5%), and urinary and sexual dysfunctions (<5%). Few studies have described the prevalence of anemia after IPAA, but no conclusive findings have been reported.
  
  
  METHODS
  Patients who had undergone IPAA for UC were recruited from the UPR Inflammatory Bowel Disease Clinic and the Gastroenterology Research Unit. Demographic and medical data were obtained. Anemia was diagnosed using standard hematologic criteria. Serum iron, ferritin, transferrin, folate, vitamin B12, erythropoietin, total iron-binding capacity, reticulocyte count, peripheral smear, and bone marrow aspirate were evaluated in patients with anemia. Data analysis was performed with EPI Info version 6.4d.
  
  
  RESULTS
  Iron-deficiency anemia was identified in 55.5% (10/18) of patients and pouchitis was found in 77% (14/18). All 10 patients with anemia had pouchitis, whereas only 4 of the 8 without anemia had pouchitis. In half of the anemic patients, pouchitis was asymptomatic.
  
  
  CONCLUSIONS
  Iron-deficiency anemia may be a clinical presenting sign of pouchitis. Hemoglobin levels may be considered as surveillance tools for pouchitis in patients with IPAA.
authors.affiliation: Gastroenterology Research Unit, Department of Medicine, University of Puerto Rico School of Medicine, University of Puerto Rico, San Juan, PR.
authors.forename: Rafael J
authors.initials: RJ
authors.lastname: Pastrana
authors.forename: Esther A
authors.initials: EA
authors.lastname: Torres
authors.forename: Jesús M
authors.initials: JM
authors.lastname: Arroyo
authors.forename: Cynthia E
authors.initials: CE
authors.lastname: Rivera
authors.forename: Carlos J
authors.initials: CJ
authors.lastname: Sánchez
authors.forename: Lilliana
authors.initials: L
authors.lastname: Morales
mesh_terms: D000328:Adult; D000368:Aged; D018798:Anemia, Iron-Deficiency / Q000097:blood / Q000175:diagnosis / Q000209:etiology*; D015415:Biomarkers / Q000097:blood; D003093:Colitis, Ulcerative / Q000601:surgery; D039021:Colonic Pouches / Q000009:adverse effects; D016099:Endoscopy, Gastrointestinal; D005260:Female; D005500:Follow-Up Studies; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007501:Iron / Q000097:blood; D008297:Male; D008875:Middle Aged; D019449:Pouchitis / Q000150:complications* / Q000175:diagnosis; D012720:Severity of Illness Index
chemical_list: D015415:Biomarkers; D006454:Hemoglobins; D007501:Iron