Pharmacokinetics and milk penetration of ibafloxacin after intravenous administration to lactating goats.
The pharmacokinetic behavior of ibafloxacin was studied after intravenous administration of a single dose of 15 mg/kg to 6 healthy lactating goats. Plasma concentrations of ibafloxacin were determined by high-performance liquid chromatography with fluorescence detection. The data for concentration versus time could best be described by a 2-compartment model. The mean plasma ibafloxacin clearance (and standard error) was 1.05 (0.10) L/h x kg. The mean steady-state volume of distribution was 1.65 (0.42) L/kg. The mean elimination half-life was 3.76 (0.30) h. Ibafloxacin penetration from the blood to the milk was poor. The ratio between the areas under the concentration-time curve of milk and plasma was 0.20 (0.01), indicating scant penetration of ibafloxacin into the milk.
Marín
Pedro
P
Department of Pharmacology, Faculty of Veterinary Medicine, University of Murcia, Campus de Espinardo, 30.071-Murcia, Spain. pmarin@um.es
Cárceles
Carlos M
CM
Escudero
Elisa
E
Fernández-Varón
Emilio
E
D000818:Animals; D019540:Area Under Curve; D002851:Chromatography, High Pressure Liquid / Q000379:methods / Q000662:veterinary; D004350:Drug Residues / Q000032:analysis*; D005260:Female; D005453:Fluorescence; D006041:Goats / Q000097:blood / Q000378:metabolism*; D006207:Half-Life; D007275:Injections, Intravenous / Q000662:veterinary; D007774:Lactation / Q000378:metabolism*; D008892:Milk / Q000737:chemistry*; D011807:Quinolizines / Q000493:pharmacokinetics*
D011807:Quinolizines; C049886:ibafloxacin