title: Clinical aspects of the link between chronic sinonasal diseases and asthma.
abstract: Chronic sinonasal diseases (CSDs) are common comorbidity of asthma. The aim of this study was to assess comprehensively CSD in a population of asthma patients and determine whether the clinical factors in both diseases were related to each other. Eighty adult stable asthmatic patients with sinonasal symptoms (SNSs) of 3 months and who were nonresponsive to aggressive medical treatment were prospectively investigated. All patients underwent a detailed ear, nose, and throat examination and were evaluated by paranasal sinus computed tomography (PNS-CT). The severity of asthma was compared with SNS scores (SNSSs) and sinonasal involvement on PNS-CT. Asthma was severe in 12.5%, moderate in 55%, and mild in 32.5% of cases. There were 15 (18.7%) patients in stage 0, 16 (20%) patients in stage 1, 21 (26.2%) patients in stage 2, and 28 (35%) patients in stage 3 according to PNS-CT scoring. There was no correlation between asthma severity and CT stages, total opacification scores (TOSs), anatomic variations, and SNSSs. Although SNSSs were similar in patients with nasal polyps (NPs) and without NPs, patients with NPs showed significantly higher TOSs and CT stages (p < 0.05). The presence of NPs and age and duration of disease were related to severity of asthma (p < 0.05). Nonatopic asthmatic patients had both more severe asthma (p = 0.05) and more extensive CT findings (p = 0.01). The use of clinical symptoms alone is not very reliable in predicting the presence or severity of CSD. Therefore, SNSs should be supported with objective criteria such as nasal endoscopy and PNS-CT scan. Furthermore, sinonasal involvement may exist independently from severity of asthma.
authors.affiliation: Division of Allergic Diseases, Department of Respiratory Diseases, Ankara University School of Medicine, Ankara, Turkey. bdursun@medicine.ankara.edu.tr
authors.forename: A Berna
authors.initials: AB
authors.lastname: Dursun
authors.forename: Betül Ayşe
authors.initials: BA
authors.lastname: Sin
authors.forename: Engin
authors.initials: E
authors.lastname: Dursun
authors.forename: Zeynep
authors.initials: Z
authors.lastname: Misirligil
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001249:Asthma / Q000175:diagnosis / Q000235:genetics / Q000503:physiopathology*; D002908:Chronic Disease; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000235:genetics; D008297:Male; D008875:Middle Aged; D010254:Paranasal Sinus Diseases / Q000175:diagnosis / Q000235:genetics / Q000503:physiopathology*; D012720:Severity of Illness Index; D012737:Sex Factors; D012907:Smoking / Q000503:physiopathology