title: Vancomycin-resistant Enterococcus faecalis endocarditis: linezolid failure and strain characterization of virulence factors.
abstract: Infective endocarditis due to vancomycin-resistant (VR) Enterococcus faecalis has only rarely been reported. We report a case of VR E. faecalis endocarditis that failed to respond to linezolid therapy, outline the virulence traits of the isolate, and review previously published cases of VR E. faecalis endocarditis.
authors.affiliation: Division of Infectious Diseases, Department of Medicine, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA. tsigrelis.constantine@mayo.edu
authors.forename: Constantine
authors.initials: C
authors.lastname: Tsigrelis
authors.forename: Kavindra V
authors.initials: KV
authors.lastname: Singh
authors.forename: Thais D
authors.initials: TD
authors.lastname: Coutinho
authors.forename: Barbara E
authors.initials: BE
authors.lastname: Murray
authors.forename: Larry M
authors.initials: LM
authors.lastname: Baddour
mesh_terms: D000081:Acetamides / Q000627:therapeutic use*; D000328:Adult; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D004697:Endocarditis, Bacterial / Q000188:drug therapy* / Q000382:microbiology; D013293:Enterococcus faecalis / Q000145:classification / Q000187:drug effects* / Q000472:pathogenicity*; D005260:Female; D016908:Gram-Positive Bacterial Infections / Q000188:drug therapy / Q000382:microbiology; D006801:Humans; D000069349:Linezolid; D023303:Oxazolidinones / Q000627:therapeutic use*; D017211:Treatment Failure; D020713:Vancomycin Resistance; D014774:Virulence; D037521:Virulence Factors / Q000235:genetics / Q000378:metabolism
chemical_list: D000081:Acetamides; D000890:Anti-Infective Agents; D001426:Bacterial Proteins; D023303:Oxazolidinones; D037521:Virulence Factors; D000069349:Linezolid