Growth regulation: a beginning for the hippo pathway.
A signaling pathway involving two protein kinases, Hippo and Warts, restricts the growth of imaginal discs in Drosophila. Four recent studies taken together show that the protocadherin Fat can regulate Warts in two different ways.
Hariharan
Iswar K
IK
Department of Molecular and Cell Biology, 361 LSA, University of California Berkeley, Berkeley, California 94720, USA.
D000818:Animals; D015815:Cell Adhesion Molecules / Q000378:metabolism*; D018797:Cell Cycle Proteins / Q000378:metabolism; D004330:Drosophila / Q000254:growth & development* / Q000378:metabolism; D029721:Drosophila Proteins / Q000378:metabolism*; D005123:Eye / Q000254:growth & development / Q000378:metabolism; D047908:Intracellular Signaling Peptides and Proteins; D007814:Larva / Q000378:metabolism; D008565:Membrane Proteins / Q000378:metabolism; D008954:Models, Biological; D011494:Protein Kinases / Q000378:metabolism*; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D015398:Signal Transduction; D014921:Wings, Animal / Q000254:growth & development / Q000378:metabolism; D000099317:Hippo Kinases
D015815:Cell Adhesion Molecules; D018797:Cell Cycle Proteins; D029721:Drosophila Proteins; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins; D011494:Protein Kinases; D017346:Protein Serine-Threonine Kinases; C085090:ex protein, Drosophila; C472307:ft protein, Drosophila; C465504:sav protein, Drosophila; C093503:wts protein, Drosophila; C499474:hpo protein, Drosophila; D000099317:Hippo Kinases