Spatial distribution patterns of excitatory and inhibitory synapses in the dendritic tree differ between jaw-closing and -opening motoneurons.
This paper reviews recent data on the spatial distribution of inhibitory and excitatory synapses on the dendritic tree of jaw-closing (JC) and -opening (JO) motoneurons in the cat, in which a combination of techniques employing intracellular injections of horseradish peroxidase and postembedding immunogold labelling was used. The dendritic tree is divided into three segments: primary and distal dendrites and intermediate dendrites between the two segments. The proportion of inhibitory boutons (immunoreactive for GABA and/or glycine) is slightly higher than proportion of excitatory boutons (immunoreactive for glutamate) in JC motoneurons, but this trend is reversed in JO motoneurons. In the two kinds of motoneuron, boutons immunoreactive to glycine alone are more numerous than boutons double-labelled to GABA and glycine, which, in turn, occur more frequently than boutons immunoreactive to GABA alone. In JC motoneurons, the packing density (number of boutons per 100 microm(2)) of the inhibitory boutons decreases somatofugally, but this trend is not applicable to the excitatory boutons. In contrast, the packing density of the inhibitory and excitatory boutons in JO motoneurons does not significantly differ among the three dendritic compartments, though it is slightly higher for the excitatory than the inhibitory ones on each dendritic segment. These differences have important implications for synaptic integration in JC and JO motoneurons.
Shigenaga
Yoshio
Y
Department of Oral Anatomy and Neurobiology, Graduate School of Dentistry, Osaka University, Suita, Osaka 565-0871, Japan. sigenaga@dent.osaka-u.a.jp
Bae
Yong Chul
YC
Moritani
Masayuki
M
Yoshida
Atsushi
A
D000818:Animals; D002415:Cats; D003712:Dendrites / Q000648:ultrastructure*; D018698:Glutamic Acid / Q000378:metabolism; D005998:Glycine / Q000378:metabolism; D008409:Mastication / Q000502:physiology*; D008410:Masticatory Muscles / Q000294:innervation* / Q000648:ultrastructure; D016253:Microscopy, Immunoelectron; D009046:Motor Neurons / Q000648:ultrastructure*; D013569:Synapses / Q000648:ultrastructure*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid; D005998:Glycine