Neighboring-site effects of amino acid mutation.
Although the context dependence of nucleotide mutation has been supported by accumulating theoretical and experimental evidence, whether this effect can be extended to amino acid mutation remains obscure. As the amino acid doublets (20 x 20) are much more diverse than their nucleotide counterparts (4 x 4), any attempt to address the neighboring-site effects of amino acid mutation was frustrated by deficient amino acid mutation data. Based on the recently revealed 599,745 mutation sites in 45,137 orthologous proteins, we provide solid evidence for the first time to support the existence of neighboring-site effects in amino acid mutation, which is significantly important to improving the prevalent protein-evolution models.
Wang
Guang-Zhong
GZ
Shandong Provincial Research Center for Bioinformatic Engineering and Technique, Center for Advanced Study, Shandong University of Technology, Zibo 255049, PR China.
Chen
Ling-Ling
LL
Zhang
Hong-Yu
HY
D000595:Amino Acid Sequence; D019943:Amino Acid Substitution; D000596:Amino Acids / Q000737:chemistry; D009154:Mutation
D000596:Amino Acids