Disturbances of the CD95 (APO-1/Fas) system in disorders of lymphohaematopoietic cells.
Control of tissue homeostasis is maintained through programs that balance proliferation and cell death. Physiologic cell death is primarily mediated through apoptosis. Deregulations of the cellular programs and genes that determine apoptosis have recently been considered to be involved in a variety of human diseases. One of the central regulatory systems for apoptosis is the CD95 (APO-1/Fas) system. Defects in the CD95 cell surface receptor and deregulated expression of CD95 and the CD95 ligand have been shown to be involved in diseases such as lymphoproliferation, AIDS and haematopoietic failure. This review summarizes our current knowledge on the implication of the CD95 system especially in lymphohaematopoietic diseases in humans.
Debatin
K M
KM
Hematology/Oncology, University Children's Hospital and Division of Molecular Oncology, German Cancer Research Center, Im Neuenheimer Feld 150, 69120 Heidelberg, Germany.