Antimicrobial resistance of community-acquired bloodstream isolates of viridans group streptococci.
Infections due to antimicrobial-resistant viridans group streptococci are increasing. The present study was done to determine the frequency of antibiotic resistance among community-acquired viridans group streptococci isolated from blood cultures and to identify the risk factors associated with acquiring antibiotic-resistant viridans group streptococci. Twenty-eight community-acquired viridans group streptococcal isolates were recovered from 27 patients, of which 89%, 86%, 79%, 61%, and 39% were susceptible to ceftriaxone, clindamycin, tetracycline, penicillin, and erythromycin, respectively; 100% were susceptible to levofloxacin and vancomycin. Among the patients with previous antibiotic use, 73% had penicillin non-susceptible viridans group streptococci, compared with 18% who did not receive prior antibiotics (p = 0.006). Patients with and without prior antibiotic use, 27% and 0%, respectively, had ceftriaxone non-susceptible viridans group streptococci isolates, respectively (p = 0.05). Patients with and without prior antibiotic use, 45% and 6%, respectively, had tetracycline non-susceptible viridans group streptococci isolates, respectively (p = 0.02). No other risk factors for isolation of non-susceptible viridans group streptococci were identified.
Yap
R L
RL
Division of Infectious Diseases, Rhode Island Hospital, 593 Eddy St., Providence, RI 02903, USA.
Mermel
L A
LA
Maglio
J
J
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016470:Bacteremia / Q000188:drug therapy* / Q000453:epidemiology / Q000382:microbiology; D002648:Child; D002675:Child, Preschool; D017714:Community-Acquired Infections / Q000453:epidemiology / Q000382:microbiology; D024901:Drug Resistance, Multiple, Bacterial; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D012237:Rhode Island / Q000453:epidemiology; D012307:Risk Factors; D034363:Viridans Streptococci / Q000187:drug effects* / Q000472:pathogenicity*