title: Functional imaging before and after constraint-induced language therapy for aphasia using magnetoencephalography.
abstract: Five patients with chronic aphasia underwent functional imaging using magnetoencephalography (MEG) before and after constraint-induced language therapy (CILT). Patients who responded well to CILT exhibited a greater degree of late MEG activation in posterior language areas of the left hemisphere and homotopic areas of the right hemisphere prior to therapy than those who did not respond well. Response to CILT, however, was positively correlated with the degree of pre-therapy MEG activity within posterior areas of the right hemisphere only on an individual basis.
authors.affiliation: Division of Clinical Neurosciences in the Department of Neurosurgery, University of Texas - Houston Health Science Center, Houston, Texas 77030, USA. Joshua.i.breier@uth.tmc.edu
authors.forename: Joshua I
authors.initials: JI
authors.lastname: Breier
authors.forename: Lynn M
authors.initials: LM
authors.lastname: Maher
authors.forename: Barbra
authors.initials: B
authors.lastname: Novak
authors.forename: Andrew C
authors.initials: AC
authors.lastname: Papanicolaou
mesh_terms: D000368:Aged; D001037:Aphasia / Q000175:diagnosis* / Q000503:physiopathology / Q000628:therapy*; D001931:Brain Mapping / Q000379:methods; D015984:Causality; D002540:Cerebral Cortex / Q000033:anatomy & histology / Q000503:physiopathology*; D004522:Educational Status; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D007802:Language; D007807:Language Tests; D007808:Language Therapy / Q000379:methods* / Q000639:trends; D008279:Magnetic Resonance Imaging; D015225:Magnetoencephalography / Q000379:methods* / Q000639:trends; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011930:Reaction Time / Q000502:physiology; D020127:Recovery of Function / Q000502:physiology; D016896:Treatment Outcome; D014705:Verbal Behavior / Q000502:physiology