title: Quality of life in patients with hepatocellular carcinoma received surgical resection.
abstract: BACKGROUND
  Hepatocellular carcinoma (HCC) is one the most common malignancies in the world. As the prognosis for HCC patients is poor, the quality of life (QOL) is becoming more important on the outcome assessments. The aim of this study was to evaluate QOL in HCC patients.
  
  
  METHODS
  A total of 161 patients with HCC were enrolled at a university hospital. Most of these patients received surgical resections. They were assessed with Taiwan versions of WHOQOL-BREF, EORTC QLQ-C30, and utility measures. The WHOQOL-BREF domain scores for the HCC patients were compared to healthy normative Taiwan population, using general linear models controlling for gender and age. Multiple logistic regressions were applied to explore association between a better QOL and clinical/sociodemographic variables.
  
  
  RESULTS
  Compared with healthy people, the HCC patients had reduced QOL in physical domains, but better environmental QOL. After controlling gender, age, education, and employment, duration of HCC more than 1 year was associated with better QOL scores. WHOQOL-BREF could be cross-validated with EORTC QLQ-C30.
  
  
  CONCLUSIONS
  Survival over 1 year was associated with better QOL in HCC patients. WHOQOL-BREF could be a valid QOL instrument for the assessments of QOL in HCC patients.
authors.affiliation: Department of Neurology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
authors.forename: Lukas Jyuhn-Hsiarn
authors.initials: LJ
authors.lastname: Lee
authors.forename: Chien-Hung
authors.initials: CH
authors.lastname: Chen
authors.forename: Grace
authors.initials: G
authors.lastname: Yao
authors.forename: Chih-Wen
authors.initials: CW
authors.lastname: Chung
authors.forename: Jin-Chuan
authors.initials: JC
authors.lastname: Sheu
authors.forename: Po-Huang
authors.initials: PH
authors.lastname: Lee
authors.forename: Yih-Jian
authors.initials: YJ
authors.lastname: Tsai
authors.forename: Jung-Der
authors.initials: JD
authors.lastname: Wang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D006528:Carcinoma, Hepatocellular / Q000401:mortality / Q000523:psychology* / Q000601:surgery*; D005163:Factor Analysis, Statistical; D005260:Female; D006305:Health Status Indicators; D006498:Hepatectomy; D006801:Humans; D008113:Liver Neoplasms / Q000401:mortality / Q000523:psychology* / Q000601:surgery*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D015203:Reproducibility of Results