Effect of Thymol on the spontaneous contractile activity of the smooth muscles.
Effects of Thymol on the spontaneous contractile activity (SCA) have been found in in vitro experiments with circular smooth-muscle strips (SMAs) from guinea pig stomach and vena portae. Thymol was found to possess an agonistic effect on the alpha(1)-, alpha(2)- and beta-adrenergic receptors. Its spasmolytic effect is registered at doses higher than 10(-6)M. Thymol in a dose of 10(-4)M inhibits 100% the SCA of the SMAs and reduces the excitatory effect of 10(-5)M ACH to 35%. It is assumed that Thymol has an analgesic effect through its action on the alpha(2)-adrenergic receptors of the nerve cells. By influencing the beta-adrenergic receptors in the adipose cells, it is possible to induce increased synthesis of fatty acids and glycerol, which is a prerequisite for increased heat release.
Beer
A-M
AM
Department of True Naturopathy, Blankenstein Hospital, Im Vogelsang 5-11, 45527 Hattingen, Germany. andre.beer@klinik-Blankenstein.de
Lukanov
J
J
Sagorchev
P
P
D000322:Adrenergic Agonists / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D004305:Dose-Response Relationship, Drug; D006168:Guinea Pigs; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects*; D008517:Phytotherapy; D011941:Receptors, Adrenergic / Q000187:drug effects; D013943:Thymol / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D046930:Thymus Plant
D000322:Adrenergic Agonists; D011941:Receptors, Adrenergic; D013943:Thymol