title: Poor prognosis of intraoperative rupture of mature cystic teratoma with malignant transformation.
abstract: OBJECTIVE
  To present the phenomenon of the postoperative rapid progression of mature cystic teratoma (MCT) with malignant transformation (MT) when intraoperative spillage occurs during operation.
  
  
  METHODS
  Two patients with MCT were treated, one with total hysterectomy plus bilateral salpingo-oophorectomy in an exploratory laparotomy, and the other with cystectomy with laparoscopy, respectively. Tumor spillage occurred during both operations. The postoperative pathology showed MCT with MT (squamous cell carcinoma type). Both patients were referred to our hospital and underwent treatment (3 months and 8 days, respectively, after the initial operation). At the secondary laparotomy for staging surgery, tumor dissemination was observed in both patients.
  
  
  CONCLUSIONS
  Whether or not tumor dissemination is correlated with tumor rupture during operation, we emphasize that any patient with a preoperative diagnosis of MCT should have it removed intact to avoid the possibly catastrophic event of tumor dissemination.
authors.affiliation: Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, and Institute of Emergency and Critical Care Medicine, National Yang-Ming University, Taipei, Taiwan.
authors.forename: Kuo-Chang
authors.initials: KC
authors.lastname: Wen
authors.forename: Wei-Ming
authors.initials: WM
authors.lastname: Hu
authors.forename: Nae-Fang
authors.initials: NF
authors.lastname: Twu
authors.forename: Pwu
authors.initials: P
authors.lastname: Chen
authors.forename: Peng-Hui
authors.initials: PH
authors.lastname: Wang
mesh_terms: D000038:Abscess / Q000601:surgery; D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D002471:Cell Transformation, Neoplastic; D017024:Chemotherapy, Adjuvant; D018450:Disease Progression; D005184:Fallopian Tube Diseases / Q000601:surgery; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007431:Intraoperative Complications / Q000473:pathology*; D008875:Middle Aged; D010049:Ovarian Diseases / Q000601:surgery; D010051:Ovarian Neoplasms / Q000473:pathology* / Q000601:surgery; D011379:Prognosis; D013724:Teratoma / Q000473:pathology* / Q000601:surgery