Pretreatment with empty liposomes attenuates the immunopathology of invasive pulmonary aspergillosis in corticosteroid-immunosuppressed mice.
In a nonneutropenic murine model of invasive pulmonary aspergillosis, pretreatment with empty liposomes (E-lipo) was nearly as effective as 10 mg/kg of body weight liposomal amphotericin B and superior to 1 mg/kg amphotericin B deoxycholate. The beneficial immunomodulatory properties of E-lipo appear to compensate for their lack of direct antifungal activity.
Lewis
Russell E
RE
Department of Clinical Sciences and Administration, The University of Houston College of Pharmacy, Texas Medical Center Campus, 1441 Moursund Street, Houston, TX 77030, USA. rlewis@uh.edu
Chamilos
Georgios
G
Prince
Randall A
RA
Kontoyiannis
Dimitrios P
DP
D000305:Adrenal Cortex Hormones / Q000494:pharmacology*; D000666:Amphotericin B / Q000494:pharmacology; D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology; D001229:Aspergillosis, Allergic Bronchopulmonary / Q000188:drug therapy* / Q000276:immunology* / Q000473:pathology; D004337:Drug Carriers / Q000494:pharmacology; D005260:Female; D025301:Hyphae / Q000276:immunology; D007155:Immunologic Factors; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D008081:Liposomes / Q000494:pharmacology*; D008168:Lung / Q000382:microbiology / Q000473:pathology; D051379:Mice; D008807:Mice, Inbred BALB C; D009504:Neutrophils / Q000187:drug effects / Q000276:immunology; D013534:Survival
D000305:Adrenal Cortex Hormones; D000935:Antifungal Agents; D004337:Drug Carriers; D007155:Immunologic Factors; D007166:Immunosuppressive Agents; D008081:Liposomes; D000666:Amphotericin B