title: Dynamic evolution of the CYP2ABFGST gene cluster in primates.
abstract: We have annotated and analyzed sequences from the CYP2ABFGST gene cluster for the chimpanzee and the Rhesus macaque, and compared them in detail to the complete map of the syntenic human cluster. While the macaque cluster has accumulated substantial differences in gene number and organization relative to the other two species, the chimpanzee cluster has remained surprisingly similar to the human cluster, given the evolutionary volatility of this gene family. The comparison will allow us to further refine our model of the evolution of this gene family in mammals.
authors.affiliation: Department of Zoology, Miami University, Oxford, OH 45056, USA. hoffmasm@muohio.edu
authors.forename: Susan M G
authors.initials: SM
authors.lastname: Hoffman
authors.forename: Shengyong
authors.initials: S
authors.lastname: Hu
mesh_terms: D000818:Animals; D001189:Aryl Hydrocarbon Hydroxylases / Q000235:genetics*; D002874:Chromosome Mapping; D019143:Evolution, Molecular; D006801:Humans; D008253:Macaca mulatta; D005810:Multigene Family; D002679:Pan troglodytes; D013250:Steroid Hydroxylases / Q000235:genetics*
chemical_list: D013250:Steroid Hydroxylases; D001189:Aryl Hydrocarbon Hydroxylases; C029009:steroid hormone 7-alpha-hydroxylase