Diphenyl ditelluride effect on embryo/fetal development in mice: interspecies differences.
It is well established that diphenyl ditelluride, (PhTe)(2), is a potent teratogen in rats, however, little is known about its effects on embryo/fetal development in mice. The present study was undertaken to investigate whether any differences exist on embryo/fetal development of mice exposed to (PhTe)(2) during distinctive periods of gestation compared to rats. Dams were treated subcutaneously (s.c.) with 0.12 or 60.0 mg/kg (PhTe)(2) on gestational day (GD) 4, 8 or 14. Cesarean section was performed on GD18 and external and skeletal alterations were examined. The lower dose did not affect any parameter evaluated in mouse fetuses. The maternal body weight for 60 mg/kg (PhTe)(2) groups, at all periods studied, was not affected. Maternal liver and spleen weights were increased at GD8. At GD14, maternal relative weight of kidney was also increased. A significant reduction in the number of implantation sites at GD4 was found. At GD4 and GD14, there was a reduction in the fetal weight and biometry. A few signs of reduced ossification in sternebrae and limbs were observed at GD14 in (PhTe)(2) group. In conclusion, (PhTe)(2) was not toxic to dams and affected some fetal endpoints only at the dose about 500-fold higher than the dose that was teratogenic in rats, suggesting a different developmental toxicity induced by (PhTe)(2) among species. Thus, the mice were less susceptible to toxic effects induced by (PhTe)(2) than were rats.
Roman
Silvane Souza
SS
Departamento de Química, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, CEP 97105-900, Santa Maria, RS, Brazil.
Nava
Alexandra
A
Favero
Alexandre Marafon
AM
Weis
Simone Nardin
SN
Zeni
Gilson
G
Rocha
Joao B T
JB
Nogueira
Cristina Wayne
CW
D000818:Animals; D001555:Benzene Derivatives / Q000633:toxicity*; D001842:Bone and Bones / Q000187:drug effects / Q000196:embryology; D004305:Dose-Response Relationship, Drug; D010064:Embryo Implantation / Q000187:drug effects; D047108:Embryonic Development / Q000187:drug effects*; D005260:Female; D047109:Fetal Development / Q000187:drug effects*; D020567:Fetal Weight / Q000187:drug effects; D007279:Injections, Subcutaneous; D008099:Liver / Q000187:drug effects / Q000473:pathology; D018811:Maternal Exposure; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D009942:Organometallic Compounds / Q000633:toxicity*; D010012:Osteogenesis / Q000187:drug effects; D011247:Pregnancy; D013045:Species Specificity; D013154:Spleen / Q000187:drug effects / Q000473:pathology; D013691:Tellurium; D013723:Teratogens / Q000633:toxicity*; D013997:Time Factors
D001555:Benzene Derivatives; D009942:Organometallic Compounds; D013723:Teratogens; C434247:diphenylditelluride; D013691:Tellurium