Tumorigenic potential and the molecular mechanism of the carcinogenic effect exerted by 2-nitroanisole.
The host-mediated in vitro/in vivo assay system was used to evaluate the tumorigenic potential of the aromatic nitro compound 2-nitroanisole (2-NA). After intraperitoneal administration of the compound, resident macrophages were recovered by peritoneal lavage from treated and untreated mice and cultured in soft agar. 2-NA was shown to be carcinogenic, and the tumorigenic potential was evaluated. Additionally, by establishment of a transformed peritoneal macrophage cell line, the underlying molecular mechanism of 2-NA's carcinogenic effect was studied.
Esmaeili
A
A
Department of Pediatric Cardiology, Johann Wolfgang Goethe University Hospital, 60590 Frankfurt am Main, Germany.
Schlatterer
K
K
Demirhan
I
I
Schlatterer
B
B
Nauck
M
M
Chandra
P
P
Chandra
A
A
D000818:Animals; D000840:Anisoles / Q000737:chemistry / Q000494:pharmacology*; D002273:Carcinogens / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects; D004591:Electrophoresis, Polyacrylamide Gel; D008264:Macrophages / Q000187:drug effects; D008297:Male; D051379:Mice; D013329:Structure-Activity Relationship
D000840:Anisoles; D002273:Carcinogens; C005328:2-nitroanisole