title: Interleukin-10 [ATA] promoter haplotype and prostate cancer risk: a population-based study.
abstract: Interleukin-10 (IL-10) is a multifunctional cytokine acting as inhibitor of inflammatory and immune responses as well as tumour induced angiogenesis. A common [ATA] haplotype formed by polymorphisms at positions -1082, -819 and -592in the promoter of the IL-10 gene is a strong determinant for IL-10 expression. The presence of this haplotype can be determined by analysis of the -592C>A polymorphism. To analyse the role of the IL-10 [ATA] haplotype in prostate cancer we performed a case-control study including 561 prostate cancer patients and 561 male, age-matched, control subjects without malignant disease. The IL-10 -592C>A polymorphism was determined by a 5'-nuclease assay (TaqMan). IL-10 -592 CC, CA and AA genotype frequencies were not significantly different between patients (53.6%, 40.0%, 6.4%) and controls (54.3%, 39.6%, 6.1%; p=0.96). IL-10 genotypes were furthermore not associated with tumour characteristics such as histological grade, T stage, PSA levels at diagnosis, or age at diagnosis. Therefore we conclude that the IL-10 -592C>A promoter polymorphism, tagging the IL-10 low-producer [ATA] haplotype, is not associated with risk for prostate cancer.
authors.affiliation: Department of Therapeutic Radiology and Oncology, Medical University of Graz, Auenbruggerplatz 32, 8036 Graz, Austria. tanja.eder@klinikum-graz.at
authors.forename: Tanja
authors.initials: T
authors.lastname: Eder
authors.forename: Ramona
authors.initials: R
authors.lastname: Mayer
authors.forename: Uwe
authors.initials: U
authors.lastname: Langsenlehner
authors.forename: Wilfried
authors.initials: W
authors.lastname: Renner
authors.forename: Peter
authors.initials: P
authors.lastname: Krippl
authors.forename: Thomas C
authors.initials: TC
authors.lastname: Wascher
authors.forename: Karl
authors.initials: K
authors.lastname: Pummer
authors.forename: Karin S
authors.initials: KS
authors.lastname: Kapp
mesh_terms: D000368:Aged; D006239:Haplotypes / Q000235:genetics*; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D008297:Male; D011110:Polymorphism, Genetic / Q000235:genetics; D011401:Promoter Regions, Genetic / Q000235:genetics*; D011471:Prostatic Neoplasms / Q000235:genetics*; D012307:Risk Factors
chemical_list: D016753:Interleukin-10