[A short test for potential carcinogenicity of water soluble synthetic polymers].
The effect of synthetic water-soluble polymer with different structure on the appearance in SZNA mice of carcinogen-protein adducts (CPA) containing endogenous carcinogen, 3-oxyanthranilic acid (3-OAA), was investigated. CPA containing 3-OAA (3-OAA-CPA) were detected during the administration of 24 of 30 investigated polymers. The induction of 3-OAA-CPA and the character of their distribution in the organism (in all investigated tissues: serum, extracts of liver, spleen, lungs and kidneys tissues or in single tissues) depended on the chemical structure of polymers. It is concluded, that synthetic polymers represent potential cancerogenic danger, because their administration causes formation of 3-OAA-CPA in the organism of animals.
Belokhvostova
A T
AT
Postapenkova
L S
LS
Panarin
E F
EF
Solovskiĭ
M V
MV
Ivanova
N P
NP
Nazarova
O V
OV
Gavrilova
I I
II
Ershov
A Iu
AIu
D000818:Animals; D015197:Carcinogenicity Tests / Q000379:methods; D002273:Carcinogens / Q000633:toxicity*; D051379:Mice; D011108:Polymers / Q000633:toxicity*; D062367:ortho-Aminobenzoates / Q000633:toxicity*
D002273:Carcinogens; D011108:Polymers; D062367:ortho-Aminobenzoates; C008740:3-oxyanthranilic acid