title: Relationships between degree of azotaemia and blood pressure, urinary protein:creatinine ratio and fractional excretion of electrolytes in dogs with renal azotaemia.
abstract: Blood pressure (BP) was measured in 31 renal azotaemic dogs by oscillometric measurement at the posterior tibia artery, and urine and blood samples were collected. Haematology, blood chemistry and urinalysis were performed and urinary protein:creatinine ratio (UPC) and fractional excretions of electrolytes (FE(e)) were calculated. The results showed that only 19% of dogs with renal azotaemia were hypertensive, whereas almost all of them had high urinary protein and electrolyte excretions. There was no association between BP, UPC and FE(e). A positive correlation was found between all pairs of electrolyte fractional excretions. When the severity of renal impairment was observed using plasma creatinine concentration, neither BP nor UPC was correlated. Only the FE( e ) was associated with the degree of azotaemia. The results suggest that dogs with renal azotaemia do not necessarily have hypertension. The fractional urinary excretion of electrolytes may be a good indicator for severity of renal dysfunction in azotaemic dogs.
authors.affiliation: Department of Physiology, Chulalongkorn University, Bangkok, Thailand. Chollada.B@Chula.ac.th
authors.forename: C
authors.initials: C
authors.lastname: Buranakarl
authors.forename: K
authors.initials: K
authors.lastname: Ankanaporn
authors.forename: S
authors.initials: S
authors.lastname: Thammacharoen
authors.forename: M
authors.initials: M
authors.lastname: Trisiriroj
authors.forename: T
authors.initials: T
authors.lastname: Maleeratmongkol
authors.forename: P
authors.initials: P
authors.lastname: Thongchai
authors.forename: S
authors.initials: S
authors.lastname: Panasjaroen
mesh_terms: D000818:Animals; D053099:Azotemia / Q000473:pathology / Q000652:urine / Q000662:veterinary*; D001794:Blood Pressure; D002712:Chlorides / Q000652:urine; D003404:Creatinine / Q000652:urine; D004283:Dog Diseases / Q000473:pathology* / Q000652:urine*; D004285:Dogs; D005260:Female; D006973:Hypertension / Q000473:pathology / Q000652:urine / Q000662:veterinary*; D008274:Magnesium / Q000652:urine; D008297:Male; D011188:Potassium / Q000652:urine; D011507:Proteinuria / Q000473:pathology / Q000652:urine / Q000662:veterinary; D012964:Sodium / Q000652:urine; D018709:Statistics, Nonparametric
chemical_list: D002712:Chlorides; D012964:Sodium; D003404:Creatinine; D008274:Magnesium; D011188:Potassium