title: Intraocular lens opacification after nonpenetrating glaucoma surgery with mitomycin-C.
abstract: A 58-year-old woman had successful phacoemulsification with intraocular lens (IOL) implantation in January 2001. Two years later, nonpenetrating glaucoma surgery with mitomycin-C (MMC) 0.02% was performed for uncontrolled glaucoma. Two months later, opacification of the anterior IOL surface was observed. The IOL was removed and a hydrophobic acrylic AcrySof IOL (Alcon) implanted. The opacified IOL was studied by flame atomic absorption spectrometry, which showed the presence of calcium carbonate. A new IOL of the same model was placed in an aqueous solution with calcium carbonate and basic pH, and the same opacification developed. We hypothesize that the change in aqueous humor pH after glaucoma surgery and the characteristics of the IOL precipitated deposition of calcium.
authors.affiliation: Department of Ophthalmology, Clínica Universitaria de Navarra, Universidad de Navarra, Pamplona, Spain. jmoreno@unav.es
authors.forename: Javier
authors.initials: J
authors.lastname: Moreno-Montañés
authors.forename: Juan Antonio
authors.initials: JA
authors.lastname: Palop
authors.forename: Pío
authors.initials: P
authors.lastname: García-Gómez
authors.forename: Henar
authors.initials: H
authors.lastname: Heras
authors.forename: José Angel
authors.initials: JA
authors.lastname: Cristóbal
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage*; D002114:Calcinosis / Q000209:etiology; D002119:Calcium Carbonate / Q000032:analysis; D003131:Combined Modality Therapy; D020878:Device Removal; D005260:Female; D005902:Glaucoma, Open-Angle / Q000188:drug therapy / Q000601:surgery*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007429:Intraocular Pressure; D019654:Lens Implantation, Intraocular; D007910:Lenses, Intraocular; D008875:Middle Aged; D016685:Mitomycin / Q000008:administration & dosage*; D018918:Phacoemulsification; D011183:Postoperative Complications; D011475:Prosthesis Failure; D012086:Reoperation; D012599:Sclerostomy; D013054:Spectrophotometry, Atomic
chemical_list: D000903:Antibiotics, Antineoplastic; D016685:Mitomycin; D002119:Calcium Carbonate