Pregnancy and pregnancy outcome among women with inflammatory skin diseases.
OBJECTIVE
The effect of inflammatory skin diseases on pregnancy has been incompletely characterized. We sought to estimate the incidence of pregnancy and pregnancy outcomes among women with inflammatory skin diseases.


METHODS
Cohort study of women with atopic dermatitis (AD), psoriasis, other inflammatory skin diseases, and comparison group, followed for pregnancies and pregnancy outcomes.


RESULTS
There were 3,131 pregnancies among 64,773 woman-years (4.8/100) in women with skin diseases, and 2,592 pregnancies among 59,826 woman-years (4.3/100) in the comparison group. The age-standardized incidence of pregnancy was similar to the comparison group [rate ratio (RR) = 1.2, 95% confidence interval (CI) 1.0-1.4 for AD, RR = 1.1, 95% CI 1.0-1.2 for psoriasis, and RR = 1.1, 95% CI 1.0-1.1 for other]. Spontaneous abortion was also similar to the comparison group (RR = 1.2 for AD, 95% CI 1.0-1.4, RR = 1.1, 95% CI 1.0-1.2 for psoriasis, and RR = 1.1, 95% CI 1.0-1.1 for other).


CONCLUSIONS
Our results suggest little effect of skin disease on incidence or outcome of pregnancy.
Seeger
John D
JD
Ingenix Epidemiology, Auburndale, MA, USA. jseeger@epidemiology.com
Lanza
Lee L
LL
West
William A
WA
Fernandez
Carlos
C
Rivero
Elena
E
D000293:Adolescent; D000328:Adult; D002648:Child; D016001:Confidence Intervals; D003876:Dermatitis, Atopic / Q000453:epidemiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D008875:Middle Aged; D011247:Pregnancy; D011248:Pregnancy Complications; D011256:Pregnancy Outcome / Q000453:epidemiology*; D011565:Psoriasis / Q000453:epidemiology*; D012189:Retrospective Studies; D014481:United States / Q000453:epidemiology