ent-Abietane diterpenoids from Isodon rubescens var. rubescens.
ent-Abietane diterpenoids, hebeiabinins A-F (1-5), together with seven known diterpenoids were isolated from leaves of Isodon rubescens var. rubescens. The structures of 1-5 were established on the basis of spectroscopic analyses, including application of 2D NMR spectroscopic techniques. The diterpenoids isolated were evaluated for the cytotoxicity against A549, HT-29, and K562 tumor cells. Compound 5 was the most active with IC(50) value of 0.91 microM against A549 cells.
Huang
Sheng-Xiong
SX
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China.
Pu
Jian-Xin
JX
Xiao
Wei-Lie
WL
Li
Li-Mei
LM
Weng
Zhi-Ying
ZY
Zhou
Yan
Y
Han
Quan-Bin
QB
Peng
Shu-Lin
SL
Ding
Li-Sheng
LS
Lou
Li-Guang
LG
Sun
Han-Dong
HD
D045784:Abietanes / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D000970:Antineoplastic Agents / Q000633:toxicity; D045744:Cell Line, Tumor / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects*; D006801:Humans; D037602:Isodon / Q000737:chemistry* / Q000633:toxicity; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry*
D045784:Abietanes; D000970:Antineoplastic Agents; D010936:Plant Extracts