Increased angiogenesis at the site of abdominal aortic aneurysm rupture.
Abdominal aortic aneurysm (AAA) rupture is associated with elevated levels of matrix metalloproteinase (MMP). Medial neovascularization is a known characteristic of established AAAs and involves proteolytic degradation of extracellular matrix by MMPs to facilitate endothelial cell proliferation and migration. This study evaluated the extent of neovascularization in abdominal aortic aneurysm rupture. Results indicated upregulation of proangiogenic cytokines and increased medial neovascularization at the aneurysm rupture edge compared with paired aneurysm anterior sac. Further investigations into the role of angiogenesis in aneurysm rupture may open novel therapeutic avenues to prevent aneurysm rupture.
Choke
Edward
E
Department of Vascular Surgery, 4th Floor St. James Wing, St. George's Hospital, Blackshaw Rd., London SW17 0QT.
Cockerill
Gillian W
GW
Dawson
Joseph
J
Wilson
Richard W
RW
Jones
Alun
A
Loftus
Ian M
IM
Thompson
Matthew M
MM
D017544:Aortic Aneurysm, Abdominal / Q000235:genetics / Q000473:pathology*; D001019:Aortic Rupture / Q000235:genetics / Q000473:pathology*; D001706:Biopsy; D016207:Cytokines / Q000235:genetics; D005786:Gene Expression Regulation; D006801:Humans; D039482:Integrin alpha5 / Q000235:genetics; D009389:Neovascularization, Pathologic / Q000235:genetics / Q000473:pathology*
D016207:Cytokines; D039482:Integrin alpha5