In situ immune response in brain and kidney during early relapsing fever borreliosis.
Characterization of the host immune response during initial pathogenesis of relapsing fever neuroborreliosis would be a key to understanding Borrelia persistence and factors driving the inflammatory process. We analyzed immune cells in brain and kidney with the highly invasive B. crocidurae during the first two weeks of murine infection. In both organs, microglia and/or macrophages predominated while T-cell changes were minimal. Compared to kidney, brain neutrophils infiltrated more rapidly and B-cells were essentially absent. Our results indicate that during early neuroborreliosis, brain defense is comprised primarily of innate immune cells while adaptive immunity plays a minor role.
Andersson
Marie
M
Umeå University, Department of Molecular Biology, SE-90187 Umeå, Sweden.
Nordstrand
Annika
A
Shamaei-Tousi
Alireza
A
Jansson
Anna
A
Bergström
Sven
S
Guo
Betty P
BP
D000818:Animals; D000943:Antigens, Differentiation / Q000378:metabolism; D001899:Borrelia Infections / Q000150:complications* / Q000276:immunology; D001921:Brain / Q000276:immunology*; D007150:Immunohistochemistry / Q000379:methods; D007668:Kidney / Q000276:immunology*; D008264:Macrophages / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D019581:Neuropil / Q000378:metabolism; D012061:Relapsing Fever / Q000209:etiology* / Q000276:immunology*; D013144:Spirochaetales / Q000302:isolation & purification; D013997:Time Factors
D000943:Antigens, Differentiation