title: Long-term results of breast cancer irradiation treatment with low-dose-rate external irradiation.
abstract: OBJECTIVE
  The aim of this study was to assess beam therapy with low-dose-rate (LDR) external irradiation in a group of patients with breast cancer.
  
  
  METHODS
  This trial compared, from 1986 to 1989, patients with advanced breast cancer treated either by conventional fractionation or low-dose-rate (LDR) external radiotherapy (dose-rate 15 mGy/min, 5 sessions of 9 Gy delivered on 5 consecutive days).
  
  
  RESULTS
  A total of 21 patients were included in the fractionated therapy arm. At follow-up 15 years after treatment, 7 local recurrences had occurred, 3 patients had died of cancer, 18 patients were alive, 10 were without evidence of disease, and 6 had evidence of disease. A total of 22 patients had been included in the LDR arm of the study. Of these, 11 had received a dose of 45 Gy; thereafter, in view of severe local reactions, the dose was reduced to 35 Gy. There was no local recurrence in patients who had received 45 Gy, although there were 2 local recurrences among the 11 patients after 35 Gy. The sequelae were severe in patients who received 45 Gy but were comparable to those observed in patients treated by fractionated radiotherapy who received 35 Gy. The higher efficacy of tumor control in patients treated by LDR irradiation as well as the lower tolerance of normal tissue are probably related to the lack of repopulation.
  
  
  CONCLUSIONS
  Although the patient numbers in this study are limited, based on our study results we conclude that the data for LDR irradiation are encouraging and that further investigation is warranted.
authors.affiliation: Centre Antoine Béclère, Faculté de Médecine, Paris, France.
authors.forename: Bernard
authors.initials: B
authors.lastname: Pierquin
authors.forename: Maurice
authors.initials: M
authors.lastname: Tubiana
authors.forename: Camille
authors.initials: C
authors.lastname: Pan
authors.forename: Jean-Léon
authors.initials: JL
authors.lastname: Lagrange
authors.forename: Elie
authors.initials: E
authors.lastname: Calitchi
authors.forename: Yves
authors.initials: Y
authors.lastname: Otmezguine
mesh_terms: D001918:Brachytherapy / Q000379:methods; D001943:Breast Neoplasms / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D004307:Dose-Response Relationship, Radiation; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008408:Mastectomy; D011879:Radiotherapy Dosage