Corneal toxicity from topical ocular and systemic medications.
OBJECTIVE
To review what is known about the adverse effects on the cornea from various classes of medications. New data from previously unreported cases of drug-related corneal toxicity are included.


METHODS
Data are garnered from a Medline literature review and from case reports collected by the World Health Organization, the Food and Drug Administration, and the National Registry of Drug-Induced Ocular Side Effects.


RESULTS
Aminoglycosides, bisphosphonates, chemotherapeutic medications, cyclooxygenase-2 inhibitors, fluoroquinolones, glaucoma eye drops, topical iodine, nonsteroidal anti-inflammatory eye drops, preservatives in eye drops, retinoids, topical anesthetics, topical steroids, and some herbal medications can cause corneal toxicity in some patients.


CONCLUSIONS
Ophthalmologists need to be aware of potential corneal toxicities that can arise from commonly prescribed medications.
Fraunfelder
F W
FW
Casey Eye Institute, Oregon Health and Science University, Portland, OR 97239-4197, USA. eyedrug@ohsu.edu
D003315:Cornea / Q000187:drug effects*; D003316:Corneal Diseases / Q000139:chemically induced*; D064420:Drug-Related Side Effects and Adverse Reactions; D005260:Female; D006801:Humans; D008297:Male; D008517:Phytotherapy / Q000009:adverse effects*; D010936:Plant Extracts / Q000009:adverse effects*; D011310:Preservatives, Pharmaceutical / Q000009:adverse effects*
D010936:Plant Extracts; D011310:Preservatives, Pharmaceutical