Abnormal multifocal electroretinogram (mfERG) in ethambutol toxicity.
OBJECTIVE
To report the abnormal multifocal electroretinogram (mfERG) findings in two cases of presumed ethambutol toxicity.


METHODS
Retrospective observational case series.


METHODS
Two patients with ethambutol toxicity and visual loss.


METHODS
Multifocal electroretinography.


METHODS
Waveform measurements on multifocal electroretinography.


RESULTS
Two patients with bilateral visual loss due to ethambutol toxicity underwent mfERG testing that disclosed both diffuse and central field loss compatible with retinal dysfunction as a contributing mechanism to the visual field loss.


CONCLUSIONS
Ethambutol toxicity affects not only the optic nerve but probably other retinal elements based upon abnormal mfERG findings.
Kardon
Randy H
RH
Department of Ophthalmology, The University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242, USA.
Morrisey
Mary C
MC
Lee
Andrew G
AG
D000369:Aged, 80 and over; D000995:Antitubercular Agents / Q000009:adverse effects*; D004596:Electroretinography; D004977:Ethambutol / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008875:Middle Aged; D012160:Retina / Q000187:drug effects* / Q000503:physiopathology; D012164:Retinal Diseases / Q000139:chemically induced* / Q000175:diagnosis / Q000503:physiopathology; D014786:Vision Disorders / Q000139:chemically induced* / Q000175:diagnosis / Q000503:physiopathology; D014792:Visual Acuity; D058609:Visual Field Tests; D014794:Visual Fields
D000995:Antitubercular Agents; D004977:Ethambutol