A new Bacillus pasteurii urease inhibitor from Euphorbia decipiens.
Inhibition of Bacillus pasteurii urease enzyme by 3,7,15-tri-O-acetyl-5-O-nicotinoyl-13,14-dihydroxymyrsinol (1), a diterpene ester with a myrsinol-type skeleton, isolated from Euphorbia decipiens Boiss. and Buhse, was un-competitive consistent with the molecular docking results. The Ki value was 117.40 +/- 0.7 microM.
Lodhi
Muhammad Arif
MA
Dr. Panjwani Center for Molecular Medicine and Drug Research, HEJ Research Institute of Chemistry, University of Karachi, Karachi-75270, Pakistan.
Hussain
Javid
J
Abbasi
Muhammad Athar
MA
Jassbi
Amir Reza
AR
Choudhary
Muhammad Iqbal
MI
Ahmad
Viqar Uddin
VU
D001407:Bacillus / Q000201:enzymology*; D001665:Binding Sites; D003198:Computer Simulation; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D028481:Euphorbia / Q000737:chemistry*; D007700:Kinetics; D008958:Models, Molecular; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D017434:Protein Structure, Tertiary; D014510:Urease / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000378:metabolism
D004224:Diterpenes; D004791:Enzyme Inhibitors; D010936:Plant Extracts; D014510:Urease