Trisomy 8 as sole cytogenetic abnormality in a case of chronic lymphocytic leukemia.
A 49-year-old man, who had been diagnosed with chronic lymphocytic leukemia (CLL) in 2002, had a normal karyotype in his bone marrow. Trisomy 8 was demonstrated in his peripheral blood in 2005. Fluorescence in situ hybridization using an LSI CEP 8 probe performed on the archival bone marrow specimen showed three hybridization signals in 40% of 200 interphase cells scored. This confirmed that the trisomy 8 abnormality was present in both the blood and bone marrow samples. Trisomy 8 as the sole chromosomal abnormality in CLL is a very rare finding. The prognostic significance of trisomy 8 in CLL remains to be seen.
Lau
Lai-Ching
LC
Department of Pathology, Singapore General Hospital, Outram Road, Singapore 169608.
Kee
Su-Keyau
SK
Tien
Sim-Leng
SL
Koh Mickey
Boon-Chai
BC
D001853:Bone Marrow; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics; D015342:DNA Probes; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007399:Interphase; D007621:Karyotyping; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D014314:Trisomy
D015342:DNA Probes