title: A novel type of membranes based on cholesteryl phosphate.
abstract: Mixtures of the rigid amphiphile disodium cholesteryl phosphate (DCP) with the non-phosphorylated diacyl amphiphile dimyristoylglycerol (DMG) give self-organized systems in a wide range of pH, as demonstrated by differential microcalorimetry. These systems can be closed bilayer vesicles, as shown by optical microscopy (Nomarski and confocal). Neither DMG nor DCP, taken alone, give vesicles in these conditions but 10% DMG is enough to lead to the formation of vesicles from pH 5.8 to 9.3. These novel self-organized systems are akin to the classical eucaryotic ones, built on a phosphorylated diacylglycerol and free cholesterol (or analogues), the only difference being the site of the phosphate head-group.
authors.affiliation: Centre de Neurochimie, 5 rue Blaise Pascal, F-67084 Strasbourg.
authors.forename: Soheila
authors.initials: S
authors.lastname: Sedaghat
authors.forename: Laurent
authors.initials: L
authors.lastname: Désaubry
authors.forename: Stéphane
authors.initials: S
authors.lastname: Streiff
authors.forename: Nigel
authors.initials: N
authors.lastname: Ribeiro
authors.forename: Bernard
authors.initials: B
authors.lastname: Michels
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Nakatani
authors.forename: Guy
authors.initials: G
authors.lastname: Ourisson
mesh_terms: D002788:Cholesterol Esters / Q000032:analysis / Q000737:chemistry*; D008566:Membranes / Q000737:chemistry; D008567:Membranes, Artificial
chemical_list: D002788:Cholesterol Esters; D008567:Membranes, Artificial; C033095:cholesteryl phosphate