[Wound healing effect of Eludril in a model of human gingival mucosa].
BACKGROUND
The aim of this study was to evaluate and to compare the potential for wound healing of the buccal mucosa with the use of two mouth rinses; one containing 0.10% chlorhexidine with alcohol, the second containing 0.12% chlorhexidine without alcohol.


METHODS
Using a model of human buccal mucosa kept alive ex vivo, an immunohistochemical assessment of the mitotic potential of epithelial cells and a biochemical evaluation of the capacity of the fibroblasts of the gingival mucosa to synthesize collagen was performed.


RESULTS
A mouth rinse containing 0.10% chlorhexidine with alcohol (Eludril) did not alter the potential for epithelial proliferation and for collagen synthesis within the gingival chorion grown in survival conditions. The results revealed a significant difference between the two mouth rinses for each of the parameters studied. The most favourable results were obtained with the mouth rinse containing alcohol.


CONCLUSIONS
The presence of alcohol in a mouth rinse containing 0.10% chlorhexidine has no deleterious effects on healing capacity. On the contrary, it helps stimulate wound healing. The combination of chlorhexidine plus alcohol is superior for healing, chlorhexidine alone does not show any significant difference compared with the control.
Boisnic
S
S
Service de Stomatologie et de Chirurgie Maxillo-faciale, Hôpital de la Pitié-Salpêtrière, Paris, France.
Ben Slama
L
L
Branchet-Gumila
M C
MC
Watts
M
M
d'Arros
G
G
D000891:Anti-Infective Agents, Local / Q000494:pharmacology*; D002478:Cells, Cultured; D002710:Chlorhexidine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D003094:Collagen / Q000096:biosynthesis; D004338:Drug Combinations; D004847:Epithelial Cells / Q000187:drug effects / Q000378:metabolism; D000431:Ethanol / Q000494:pharmacology; D005347:Fibroblasts / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D008940:Mitotic Index; D009061:Mouth Mucosa / Q000166:cytology / Q000187:drug effects*; D009067:Mouthwashes / Q000494:pharmacology*; D009924:Organ Culture Techniques; D014945:Wound Healing / Q000187:drug effects*
D000891:Anti-Infective Agents, Local; D004338:Drug Combinations; D009067:Mouthwashes; D000431:Ethanol; D003094:Collagen; C010882:chlorhexidine gluconate; D002710:Chlorhexidine