Evaluation of the in vivo activity of tribendimidine against Schistosoma mansoni, Fasciola hepatica, Clonorchis sinensis, and Opisthorchis viverrini.
We examined the in vivo activity of tribendimidine against selected trematodes. A single 150-mg/kg dose of tribendimidine achieved a 99.1% reduction of Clonorchis sinensis in rats. A 400-mg/kg dose of tribendimidine reduced Opisthorchis viverrini in hamsters by 95.7%. High doses of tribendimidine showed no activity against Schistosoma mansoni and Fasciola hepatica.
Keiser
Jennifer
J
Swiss Tropical Institute, P.O. Box, CH-4002 Basel, Switzerland. jennifer.keiser@unibas.ch
Shu-Hua
Xiao
X
Chollet
Jacques
J
Tanner
Marcel
M
Utzinger
Jürg
J
D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use*; D003003:Clonorchiasis / Q000188:drug therapy* / Q000469:parasitology; D003004:Clonorchis sinensis / Q000187:drug effects; D006224:Cricetinae; D005210:Fasciola hepatica / Q000187:drug effects*; D005211:Fascioliasis / Q000188:drug therapy* / Q000469:parasitology; D005260:Female; D008297:Male; D008647:Mesocricetus; D051379:Mice; D009891:Opisthorchis / Q000187:drug effects* / Q000469:parasitology; D010655:Phenylenediamines / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D012550:Schistosoma mansoni / Q000187:drug effects*; D012555:Schistosomiasis mansoni / Q000188:drug therapy* / Q000469:parasitology*
D000871:Anthelmintics; D010655:Phenylenediamines; C056017:tribendimidine