title: Antihyperglycemic activity and chemical constituents of Eysenhardtia platycarpa.
abstract: The methanolic extracts from branches (BEP) and leaves (LEP) of Eysenhardtia platycarpa significantly decreased the blood glucose levels in normal and streptozotocin (STZ)-induced diabetic rats. One new flavone, (1"R)-5,4',1"-trihydroxy-6,7-(3",3"-dimethylchroman)flavone (1), together with the known compounds 5,7-dihydroxy-6-methyl-8-prenylflavanone (3), 5,7-dihydroxy-8-methyl-6-prenylflavanone (4), 5,7-dihydroxy-6-prenylflavanone (5), 5,7-dihydroxy-8-prenylflavanone (6), 3-O-acetyloleanolic acid (7), oleanolic acid, 3beta-acetoxy-11alpha,12alpha-epoxy-oleanan-28,13beta-olide, lupeol, betulinic acid, beta-sitosterol, beta-sitosteryl beta-D-glucopyranoside, beta-sitosteryl palmitate, and 3-O-methyl-myo-inositol were isolated from BEP. Additionally, one new flavanone, (2S)-4'-O-methyl-6-methyl-8-prenylnaringenin (2), as well as the known compounds 3, 4, 6, 4'-O-methyl-8-prenylnaringenin (8), and 5-hydroxy-7-methoxy-8-prenylflavanone (9) were isolated from LEP. 3-O-Acetyloleanolic acid (7), identified as the major constituent of BEP, showed a significant decrease (31 mg/kg of body weight, P < 0.05) in the glucose level of STZ-induced diabetic rats. The obtained results correlate with the traditional use of this species.
authors.affiliation: Instituto de Química de la Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, Coyoacán 04510, México D.F.
authors.forename: José M
authors.initials: JM
authors.lastname: Narvaez-Mastache
authors.forename: María Luisa
authors.initials: ML
authors.lastname: Garduño-Ramírez
authors.forename: Laura
authors.initials: L
authors.lastname: Alvarez
authors.forename: Guillermo
authors.initials: G
authors.lastname: Delgado
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000187:drug effects; D007887:Fabaceae / Q000737:chemistry*; D047309:Flavones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D008297:Male; D008800:Mexico; D023421:Models, Animal; D015394:Molecular Structure; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D013311:Streptozocin / Q000494:pharmacology*
chemical_list: C516421:(1''R)-5,4',1''-trihydroxy-6,7-(3'',3''-dimethylchroman)flavone; D001786:Blood Glucose; D047309:Flavones; D007004:Hypoglycemic Agents; D013311:Streptozocin