In vitro postantibiotic effect of colistin on multidrug-resistant Acinetobacter baumannii.
Infections by multidrug-resistant Acinetobacter baumannii constitute an increasing threat for critically ill patients. Colistin is often the only antimicrobial retaining activity against these strains. The postantibiotic effect (PAE) of colistin was studied on 19 isolates of A. baumannii resistant to ampicillin/sulbactam, ciprofloxacin, and carbapenems with the viable count method. The mean PAEs of 1x MIC and 4x MIC concentrations of colistin on the tested isolates were 3.90 and 4.48 h, respectively, indicating that a modified dosage scheme with increased dosing intervals might retain activity whereas minimizing the incidence of adverse effects.
Plachouras
Diamantis
D
4th Department of Internal Medicine, University of Athens, Medical School, 124 62 Athens, Greece.
Giamarellos-Bourboulis
Evangelos J
EJ
Kentepozidis
Nikolaos
N
Baziaka
Fotini
F
Karagianni
Vassiliki
V
Giamarellou
Helen
H
D040981:Acinetobacter baumannii / Q000187:drug effects* / Q000254:growth & development; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D003091:Colistin / Q000494:pharmacology*; D003470:Culture Media; D004305:Dose-Response Relationship, Drug; D024901:Drug Resistance, Multiple, Bacterial; D006801:Humans; D008826:Microbial Sensitivity Tests / Q000592:standards
D000900:Anti-Bacterial Agents; D003470:Culture Media; D003091:Colistin