Anti-ulcer activity of Adhatoda vasica Nees.
Adhatoda vasica Nees (Acantheceae), commonly known as Vasaka, is a well-known plant in indigenous systems of medicine and is used for its beneficial effects, particularly in bronchitis. The present investigation was carried out to study the anti-ulcer activity of Adhatoda vasica leaves using two ulcer models (1) Ethanol-induced, and (2) Pylorus ligation plus aspirin-induced models. Adhatoda vasica leaf powder showeda considerable degree of anti-ulcer activity in experimental rats when compared with a control. The highest degree of activity (80%) was observed in the ethanol-induced ulceration model. Results of the study suggest that in addition to its classically established pharmacological activities, the plant also has immense potential as an anti-ulcer agent of great therapeutic relevance.
Shrivastava
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N
Department of Pharmacognosy and Phytochemistry, B.V. Patel Pharmaceutical Education & Research Development Centre, Ahmedabad, Gujarat, India.
Srivastava
A
A
Banerjee
A
A
Nivsarkar
M
M
D000284:Administration, Oral; D000818:Animals; D000897:Anti-Ulcer Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D001241:Aspirin; D000431:Ethanol; D005260:Female; D027902:Justicia; D008026:Ligation; D008297:Male; D008517:Phytotherapy; D018515:Plant Leaves; D051381:Rats; D017207:Rats, Sprague-Dawley; D013276:Stomach Ulcer / Q000139:chemically induced / Q000517:prevention & control*
D000897:Anti-Ulcer Agents; D000431:Ethanol; D001241:Aspirin