Inhibition of mite-induced immunoglobulin E synthesis, airway inflammation, and hyperreactivity by herbal medicine STA-1.
The availability of STA-1 in suppressing allergen-induced immunoglobulin E (IgE) synthesis, airway inflammation and hyperreactivity in a murine model was investigated. The mice were intraperitoneally sensitized with Dermatophagoides pteronyssinus group 5 allergen (Der p 5) and orally treated with 300 mg/kg of STA-1 every other day for 14 days. The Der p 5-specific immunologic responses including changes of specific immunoglobulin G and E, cells in the broncholarvage fluid, and airway hyperreactivity were measured when mice received inhalation challenge with Der p 5 after sensitization for 21 days. By comparing with sham-treated groups, the synthesis of Der p 5-specific IgE was downregulated while the influx of eosinophils and neutrophils in the airway were remarkably reduced. In addition, Der p 5-induced airway hyperreactivity also was significantly eliminated by STA-1 treatment. These results showed that STA-1 could effectively suppress the Der p 5-induced allergic reactions, and the availability of STA-1 for the treatment of allergic asthma was demonstrated in this study.
Chang
Tung-Ti
TT
Graduate Institute of Chinese Medical Science, China Medical University, Taichung, Taiwan, Republic of China.
Huang
Chieh-Chen
CC
Hsu
Ching-Hsiang
CH
D000336:Aerosols; D000403:Airway Resistance; D000818:Animals; D000918:Antibody Specificity; D039741:Antigens, Dermatophagoides / Q000276:immunology*; D001249:Asthma / Q000473:pathology; D016535:Bronchial Hyperreactivity / Q000188:drug therapy* / Q000209:etiology; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology / Q000276:immunology; D002452:Cell Count; D004365:Drugs, Chinese Herbal / Q000009:adverse effects / Q000627:therapeutic use* / Q000633:toxicity; D005260:Female; D007073:Immunoglobulin E / Q000096:biosynthesis*; D007074:Immunoglobulin G / Q000096:biosynthesis; D007249:Inflammation / Q000188:drug therapy* / Q000209:etiology; D007928:Lethal Dose 50; D051379:Mice; D008807:Mice, Inbred BALB C
D000336:Aerosols; D039741:Antigens, Dermatophagoides; D004365:Drugs, Chinese Herbal; D007074:Immunoglobulin G; C517526:STA-1 medicine; D007073:Immunoglobulin E