title: Disseminated Mycobacterium tuberculosis infection due to interferon gamma deficiency. Response to replacement therapy.
abstract: The case of a previously healthy HIV seronegative woman with disseminated Mycobacterium tuberculosis infection and markedly reduced interferon gamma production is reported here. Complete healing of her disseminated lesions was seen only after addition of subcutaneous interferon gamma to her tuberculosis treatment.
authors.affiliation: Clinical Immunology Unit, Queens Medical Centre, Nottingham, UK. suran200@yahoo.co.uk
authors.forename: Suranjith Luke
authors.initials: SL
authors.lastname: Seneviratne
authors.forename: Rainer
authors.initials: R
authors.lastname: Doffinger
authors.forename: John
authors.initials: J
authors.lastname: Macfarlane
authors.forename: L
authors.initials: L
authors.lastname: Ceron-Gutierrez
authors.forename: M R
authors.initials: MR
authors.lastname: Amel Kashipaz
authors.forename: A
authors.initials: A
authors.lastname: Robbins
authors.forename: T
authors.initials: T
authors.lastname: Patel
authors.forename: P T
authors.initials: PT
authors.lastname: Powell
authors.forename: D S
authors.initials: DS
authors.lastname: Kumararatne
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Powell
mesh_terms: D000279:Administration, Cutaneous; D005260:Female; D018023:HIV Seronegativity / Q000276:immunology*; D006801:Humans; D007371:Interferon-gamma / Q000008:administration & dosage / Q000172:deficiency*; D008875:Middle Aged; D009169:Mycobacterium tuberculosis / Q000276:immunology*; D014376:Tuberculosis / Q000188:drug therapy / Q000276:immunology*
chemical_list: D007371:Interferon-gamma