Asymmetric division: motor persistence pays off.
A new study shows that an antagonistic force model can explain a number of complex mitotic spindle movements in the first mitosis of the Caenorhabditis elegans embryo by simply assuming that cortical force generators become increasingly persistent in their interaction with microtubules during mitosis.
Gardner
Melissa K
MK
Department of Biomedical Engineering, University of Minnesota, 7-132 Hasselmo Hall, 312 Church Street S.E., Minneapolis, Minnesota 55455, USA.
Odde
David J
DJ
D000818:Animals; D017173:Caenorhabditis elegans / Q000166:cytology / Q000196:embryology*; D029742:Caenorhabditis elegans Proteins / Q000378:metabolism; D002455:Cell Division; D004625:Embryo, Nonmammalian / Q000166:cytology* / Q000378:metabolism; D008870:Microtubules / Q000502:physiology*; D008938:Mitosis; D008954:Models, Biological; D020409:Molecular Motor Proteins / Q000378:metabolism; D008941:Spindle Apparatus / Q000378:metabolism
D029742:Caenorhabditis elegans Proteins; D020409:Molecular Motor Proteins