Absolute configuration of sporotricale and structure of 6-hydroxysporotricale.
The absolute configuration of the two stereocenters of (+)-sporotricale (2a), a bioactive phthalide secondary metabolite, was determined through circular dichroism and by applying Mosher's method. The structure of 6-hydroxysporotricale (2c), isolated from cultures in vitro of Sporotrichum laxum, was also elucidated.
Bava
Adriana
A
Dipartimento di Chimica, Materiali ed Ingegneria Chimica "Giulio Natta" del Politecnico, CNR-Istituto di Chimica del Riconoscimento Molecolare, Sezione Quilico, via Mancinelli 7, 20131 Milan, Italy.
Dallavalle
Sabrina
S
Fronza
Giovanni
G
Nasini
Gianluca
G
Vajna de Pava
Orso
O
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D001572:Benzofurans / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D002645:Chickens; D049033:Chorioallantoic Membrane / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D042783:Endothelial Cells / Q000187:drug effects; D005346:Fibroblast Growth Factors / Q000187:drug effects; D015394:Molecular Structure; D018919:Neovascularization, Physiologic / Q000187:drug effects; D013175:Sporothrix / Q000737:chemistry*; D013237:Stereoisomerism; D015053:Zygote / Q000187:drug effects
C516509:6-hydroxysporotricale; D000970:Antineoplastic Agents; D001572:Benzofurans; C516510:sporotricale; D005346:Fibroblast Growth Factors