title: Development of hepatocellular carcinoma (HCC) in a patient 17 years after recovery from chronic hepatitis B and seroconversion to anti-HBs.
abstract: A 63-year-old man was admitted to hospital in 2003 for treatment of a hepatocellular carcinoma (HCC). He was negative for HBs antigen (HBsAg) and anti-HCV antibody, and positive for anti-HBs. He had a past history of chronic hepatitis B. In 1986, HBsAg had become negative with the development of anti-HBs. In 2003, an HCC was detected and liver resection was carried out. Histological examination revealed moderately differentiated HCC and slightly fibrotic liver. It is suggested that a diagnosis of HCC, combined with negativity for HBsAg and anti-HCV antibody, may include cases of past recovery from chronic hepatitis B, such as this case.
authors.affiliation: Department of Gastroenterology and Metabology, Ehime Graduate University School of Medicine.
authors.forename: Shuichiro
authors.initials: S
authors.lastname: Shigematsu
authors.forename: Teru
authors.initials: T
authors.lastname: Kumagi
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Hiasa
authors.forename: Tomorou
authors.initials: T
authors.lastname: Yoshida
authors.forename: Masashi
authors.initials: M
authors.lastname: Hirooka
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Tokumoto
authors.forename: Bunzo
authors.initials: B
authors.lastname: Matsuura
authors.forename: Kojiro
authors.initials: K
authors.lastname: Michitaka
authors.forename: Norio
authors.initials: N
authors.lastname: Horiike
authors.forename: Taiji
authors.initials: T
authors.lastname: Tohyama
authors.forename: Morikazu
authors.initials: M
authors.lastname: Onji
mesh_terms: D000914:Antibodies, Viral / Q000276:immunology*; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis / Q000209:etiology* / Q000276:immunology; D004198:Disease Susceptibility; D006509:Hepatitis B / Q000276:immunology*; D006515:Hepatitis B virus / Q000276:immunology*; D006801:Humans; D008099:Liver / Q000473:pathology; D008113:Liver Neoplasms / Q000175:diagnosis / Q000209:etiology* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D012307:Risk Factors
chemical_list: D000914:Antibodies, Viral