Genetic diversity and population structure of Mycobacterium tuberculosis in HIV-1-infected compared with uninfected individuals in Burkina Faso.
HIV-1 infection and HIV-1-induced immune deficiency may play a role in selecting particular Mycobacterium tuberculosis (MTB) strains (i.e. genotypes). We compared 43 MTB isolates obtained from HIV-1-infected patients with 77 MTB isolates obtained from HIV-1-uninfected patients in Burkina Faso, by means of DNA fingerprinting methods (MIRU-VNTR plus spoligotyping). This study suggests a lack of structure of the MTB population caused by HIV-1 infection and a similar genetic diversity of MTB in HIV-1-infected compared with uninfected individuals.
Godreuil
Sylvain
S
Laboratoire de Bactériologie, Hôpital Universitaire Arnaud de Villeneuve, Montpellier, France.
Renaud
François
F
Van de Perre
Philippe
P
Carriere
Christian
C
Torrea
Gabriela
G
Banũls
Anne-Laure
AL
D017088:AIDS-Related Opportunistic Infections / Q000382:microbiology*; D000293:Adolescent; D000328:Adult; D000368:Aged; D002050:Burkina Faso; D016172:DNA Fingerprinting; D004269:DNA, Bacterial / Q000235:genetics; D003906:Developing Countries; D005260:Female; D014644:Genetic Variation; D015497:HIV-1; D006801:Humans; D008297:Male; D008875:Middle Aged; D009169:Mycobacterium tuberculosis / Q000235:genetics* / Q000302:isolation & purification; D014397:Tuberculosis, Pulmonary / Q000382:microbiology*
D004269:DNA, Bacterial