[Platelet peripheral benzodiazepine receptors in alcoholism].
The peripheral-type benzodiazepine receptor (PBR) is an transmembrane protein, distinct pharmacologically, structurally and functionally from the central-type benzodiazepine receptor. The kinetic binding parameters of the specific PBR ligand, the PK11195, have been evaluated in platelets from 36 male alcoholic patients in relation to 19 healthy sex-matched controls. A significant increase of mean value of platelet PBR density was observed in patients as compared to the controls (4733 +/- 379 and 3358 +/- 242 fmol/mg proteins, p < 0.005). There are no statistically significant changes in the receptor affinity values in the group of patients.
Shushpanova
T V
TV
Semke
V Ia
VIa
D000328:Adult; D000437:Alcoholism / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D001792:Blood Platelets / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011963:Receptors, GABA-A / Q000097:blood*; D012720:Severity of Illness Index
D015415:Biomarkers; D011963:Receptors, GABA-A