title: Synthesis, characterization, antibacterial activity, and interaction with DNA of the vanadyl-enrofloxacin complex.
abstract: The neutral mononuclear vanadyl complex with the quinolone antibacterial drug enrofloxacin has been prepared and characterized with physicochemical and spectroscopic techniques and molecular mechanics calculations. The interaction of the complex with calf-thymus DNA has also been investigated and the antimicrobial activity has been evaluated against three different microorganisms.
authors.affiliation: Institute of Physical Chemistry, NCSR Demokritos, GR-15310 Aghia Paraskevi Attikis, Greece.
authors.forename: Eleni K
authors.initials: EK
authors.lastname: Efthimiadou
authors.forename: Nikos
authors.initials: N
authors.lastname: Katsaros
authors.forename: Alexandra
authors.initials: A
authors.lastname: Karaliota
authors.forename: George
authors.initials: G
authors.lastname: Psomas
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D004247:DNA / Q000737:chemistry*; D000077422:Enrofloxacin; D004926:Escherichia coli / Q000187:drug effects; D024841:Fluoroquinolones / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D015363:Quinolones / Q000737:chemistry; D013057:Spectrum Analysis; D013211:Staphylococcus aureus / Q000187:drug effects; D013329:Structure-Activity Relationship; D014638:Vanadates / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones; D015363:Quinolones; D000077422:Enrofloxacin; D014638:Vanadates; D004247:DNA; C427203:calf thymus DNA