Acute lung injury/acute respiratory distress syndrome (ALI/ARDS): the mechanism, present strategies and future perspectives of therapies.
Acute lung injury/acute respiratory distress syndrome (ALI/ARDS), which manifests as non-cardiogenic pulmonary edema, respiratory distress and hypoxemia, could be resulted from various processes that directly or indirectly injure the lung. Extensive investigations in experimental models and humans with ALI/ARDS have revealed many molecular mechanisms that offer therapeutic opportunities for cell or gene therapy. Herein the present strategies and future perspectives of the treatment for ALI/ARDS, include the ventilatory, pharmacological, as well as cell therapies.
Luh
Shi-ping
SP
Department of Surgery, Chung-Shan Medical University Hospital, 402 Taichung, Taiwan, China. luh572001@yahoo.com.tw
Chiang
Chi-huei
CH
D000208:Acute Disease; D000818:Animals; D017690:Cell Transplantation; D015316:Genetic Therapy; D006801:Humans; D008168:Lung / Q000503:physiopathology; D055370:Lung Injury; D012121:Respiration, Artificial; D012128:Respiratory Distress Syndrome / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy*