Dose-dependent immune response to Mycobacterium bovis BCG vaccination in neonates.
In 10-week-old infants vaccinated at birth with Japanese Mycobacterium bovis BCG, the number of dermal needle penetrations correlated positively with frequency of proliferating CD4(+) T cells in whole blood following BCG stimulation for 6 days but did not correlate with secreted cytokine levels after 7 h or interferon CD4(+) T-cell frequency after 12 h of BCG stimulation.
Davids
Virginia
V
South African Tuberculosis Vaccine Initiative (SATVI), Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.
Hanekom
Willem
W
Gelderbloem
Sebastian J
SJ
Hawkridge
Anthony
A
Hussey
Gregory
G
Sheperd
Ronel
R
Workman
Lesley
L
Soler
Jorge
J
Murray
Rose Ann
RA
Ress
Stanley R
SR
Kaplan
Gilla
G
D001500:BCG Vaccine / Q000276:immunology*; D004306:Dose-Response Relationship, Immunologic; D006801:Humans; D007223:Infant; D007231:Infant, Newborn / Q000276:immunology*; D014376:Tuberculosis / Q000276:immunology / Q000517:prevention & control*
D001500:BCG Vaccine