Novel urease inhibitors from Daphne oleoids.
Phytochemical investigations on the chloroform and ethyl acetate soluble fractions of the roots of the Daphne oleoids led to the isolation of the coumarin glycosides 1-6. Compound 5 with IC50 values 22.05 and 26.30 microM repectively, was found to be the most active of these compounds when screened against Bacillus pasteurii and jack bean urease enzymes in a concentration-dependent fashion.
Ayaz
Muhammad
M
HEJ Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi 75270, Pakistan.
Lodhi
Muhammad Arif
MA
Riaz
Muhammad
M
Ul-haq
Azhar
A
Malik
Abdul
A
Choudhary
M Iqbal
MI
D032364:Daphne / Q000737:chemistry*; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014510:Urease / Q000037:antagonists & inhibitors* / Q000378:metabolism
D004791:Enzyme Inhibitors; D010936:Plant Extracts; D014510:Urease