Synthesis and biological evaluation of novel compounds related to 1-arylnaphthalene lignans and isoquinolines.
Novel compounds designed as hybrids of 1-arylnaphthalene lignans with isoquinoline alkaloids were prepared and evaluated for their cytotoxicities on human tumor cell lines, such as A549, Hela, PC-3, CNE, BEL-7404, and KB. Some of the synthetic compounds exhibited their IC50 values on selected cell lines at 10(-6) M scale. The preliminary CoMFA molecular-modelling studies of these synthetic analogues were also performed.
Ding
Hongxia
H
Department of Traditional Chinese Medicine and Natural Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310031, PR China.
Lu
Wei
W
Li
Haibo
H
Yang
Leixiang
L
Zhang
Qijun
Q
Zhou
Changxin
C
Wu
Xiumei
X
Baudoin
Olivier
O
Cai
Junchao
J
Guéritte
Françoise
F
Zhao
Yu
Y
D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D006801:Humans; D007546:Isoquinolines / Q000737:chemistry* / Q000494:pharmacology*; D017705:Lignans / Q000737:chemistry* / Q000494:pharmacology*; D008958:Models, Molecular; D015394:Molecular Structure
D000970:Antineoplastic Agents; D007546:Isoquinolines; D017705:Lignans