title: Selection for simple major surface protein 2 variants during Anaplasma marginale transmission to immunologically naïve animals.
abstract: Anaplasma marginale, a rickettsial pathogen, evades clearance in the animal host by antigenic variation. Under immune selection, A. marginale expresses complex major surface protein 2 mosaics, derived from multiple donor sequences. However, these mosaics have a selective advantage only in the presence of adaptive immunity and are rapidly replaced by simple variants following transmission.
authors.affiliation: Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164-7040, USA. gpalmer@vetmed.wsu.edu
authors.forename: Guy H
authors.initials: GH
authors.lastname: Palmer
authors.forename: James E
authors.initials: JE
authors.lastname: Futse
authors.forename: Christina K
authors.initials: CK
authors.lastname: Leverich
authors.forename: Donald P
authors.initials: DP
authors.lastname: Knowles
authors.forename: Fred R
authors.initials: FR
authors.lastname: Rurangirwa
authors.forename: Kelly A
authors.initials: KA
authors.lastname: Brayton
mesh_terms: D042322:Anaplasma marginale / Q000235:genetics / Q000276:immunology*; D000712:Anaplasmosis / Q000276:immunology* / Q000382:microbiology / Q000635:transmission; D000818:Animals; D000942:Antigens, Bacterial / Q000235:genetics / Q000276:immunology*; D001425:Bacterial Outer Membrane Proteins / Q000235:genetics / Q000276:immunology*; D002417:Cattle; D003870:Dermacentor / Q000382:microbiology; D007113:Immunity, Innate; D008297:Male
chemical_list: D000942:Antigens, Bacterial; D001425:Bacterial Outer Membrane Proteins; C103348:msp2 protein, Anaplasma marginale