title: Osteoclast-like giant cell tumors of the pancreas and liver.
abstract: Osteoclast-like giant cell tumors (OGCT) are rare abdominal tumors, which mainly occur in the pancreas. The neoplasms are composed of two distinct cell populations and frequently show an inhomogenous appearance with cystic structures. However, due to the rarity of these tumors, only very limited clinical data are available. Imaging features and sonographic appearance have hardly been characterized. Here we report on two cases of osteoclast-like giant cell tumors, one located within the pancreas, the other within the liver, in which OGCTs are extremely rare. Both patients were investigated by contrast sonography, which demonstrated a complex, partly cystic and strongly vascularized tumor within the head of the pancreas in the first patient and a large, hypervascularized neoplasm with calcifications within the liver in the second patient. The liver OGCT responded well to a combination of carboplatin, etoposide and paclitaxel. With a combination of surgical resection, radiofrequency ablation and chemotherapy, the patient's survival is currently more than 15 mo, making him the longest survivor with an OGCT of the liver to date.
authors.affiliation: Fourth Department of Medicine, Charité University Hospital, Berlin, Germany.
authors.forename: Juergen
authors.initials: J
authors.lastname: Bauditz
authors.forename: Birgit
authors.initials: B
authors.lastname: Rudolph
authors.forename: Wolfram
authors.initials: W
authors.lastname: Wermke
mesh_terms: D003131:Combined Modality Therapy; D003937:Diagnosis, Differential; D005870:Giant Cell Tumors / Q000098:blood supply / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy; D006801:Humans; D008113:Liver Neoplasms / Q000098:blood supply / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D010010:Osteoclasts / Q000473:pathology*; D010190:Pancreatic Neoplasms / Q000098:blood supply / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy