New benzopyran-based openers of the mitochondrial ATP-sensitive potassium channel with potent anti-ischemic properties.
This study was aimed at evaluating, on a limited number of benzopyran compounds, whether the insertion of an electron-rich spirocyclic substituent at the C4 carbon of the benzopyran molecular nucleus may improve the cardioprotective properties against ischemia. Some of the new compounds (1b, 2b, and 4b) exhibited interesting anti-ischemic properties without affecting significantly the blood pressure parameters.
Breschi
Maria C
MC
Dipartimento di Scienze Farmaceutiche and Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, Università di Pisa, Via Bonanno 6, I-56126 Pisa, Italy.
Calderone
Vincenzo
V
Martelli
Alma
A
Minutolo
Filippo
F
Rapposelli
Simona
S
Testai
Lara
L
Tonelli
Federica
F
Balsamo
Aldo
A
D000255:Adenosine Triphosphate / Q000494:pharmacology*; D000818:Animals; D001011:Aorta / Q000187:drug effects; D001578:Benzopyrans / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D002316:Cardiotonic Agents / Q000494:pharmacology*; D007511:Ischemia / Q000188:drug therapy*; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008929:Mitochondria, Heart / Q000187:drug effects* / Q000378:metabolism; D015428:Myocardial Reperfusion Injury / Q000188:drug therapy*; D015221:Potassium Channels / Q000187:drug effects*; D051381:Rats; D014664:Vasodilation / Q000187:drug effects
D001578:Benzopyrans; D002316:Cardiotonic Agents; D015221:Potassium Channels; D000255:Adenosine Triphosphate; D007770:L-Lactate Dehydrogenase