Acetyl- and butyrylcholinesterase activities decrease in human colon adenocarcinoma.
Apart from the hydrolysis of acetylcholine (ACh), acetyl- (AChE) and butyrylcholinesterase (BChE), through noncatalytic mechanisms, intervene in hematopoiesis, morphogenesis, and neurogenesis (Layer and Willbold, 1995; Soreq and Seidman, 2001). Cholinesterase (ChE) molecules occur as globular (G1, G2, and G4) and asymmetric (A4, A8, and A12) forms (Legay, 2000; Massoulié, 2002). The G species might display amphiphilic (GA) or hydrophilic (GH) properties (Perrier et al., 2002). The involvement of ChEs in tumorigenesis is supported by the measurement of ChE activity in tumors (García-Ayllón et al., 2001; Ruiz-Espejo et al., 2003), the amplification of ChE genes in leukemias and ovarian tumors, and the relationship between the expression of AChE and the aggressiveness of astrocytomas(Perry et al., 2002). This research was undertaken to determine whether ChE activity is altered in gut carcinomas.
Montenegro
María Fernanda
MF
Departamento de Bioquímica y Biología Molecular-A, Universidad de Murcia, 30071 Murcia, Spain.
Ruiz-Espejo
Francisco
F
Campoy
Francisco Javier
FJ
Muñoz-Delgado
Encarnación
E
de la Cadena
María Páez
MP
Cabezas-Herrera
Juan
J
Vidal
Cecilio J
CJ
D000110:Acetylcholinesterase / Q000378:metabolism*; D000230:Adenocarcinoma / Q000201:enzymology*; D002091:Butyrylcholinesterase / Q000378:metabolism*; D003106:Colon / Q000201:enzymology; D003110:Colonic Neoplasms / Q000201:enzymology*; D006801:Humans; D007700:Kinetics; D012007:Rectum / Q000201:enzymology; D012016:Reference Values
D000110:Acetylcholinesterase; D002091:Butyrylcholinesterase