title: Pulmonary vein total occlusion following catheter ablation for atrial fibrillation: clinical implications after long-term follow-up.
abstract: OBJECTIVE
  We present the clinical course and management outcomes of patients with total pulmonary vein occlusion (PVO).
  
  
  BACKGROUND
  Pulmonary vein occlusion is a rare complication that can develop after radiofrequency catheter ablation (RFA) of atrial fibrillation (AF). The long term follow-up data of patients diagnosed with PVO are minimal.
  
  
  METHODS
  Data from 18 patients with complete occlusion of at least one pulmonary vein (PV) were prospectively collected. All patients underwent RFA for AF using different strategies between September 1999 and May 2004. Pulmonary vein occlusion was diagnosed using computed tomography (CT) and later confirmed by angiography when intervention was warranted. Lung perfusion scans were performed on all patients before and after intervention. The percent stenoses of the veins draining each independent lung were added together to yield an average cumulative stenosis of the vascular cross-sectional area draining the affected lung (cumulative stenosis index [CSI]).
  
  
  RESULTS
  The patients' symptoms had a positive correlation with the CSI (r = 0.843, p < 0.05) and a negative one with the lung perfusion (r = -0.667, p < 0.05). A CSI > or =75% correlated well with low lung perfusion (<25%; r = -0.854, p < 0.01). Patients with a CSI > or =75% appeared to improve mostly when early (r = -0.497) and repeat dilation/stenting (r = 0.0765) were performed.
  
  
  CONCLUSIONS
  Patients with single PVO are mostly asymptomatic and should undergo routine imaging. On the other hand, patients with concomitant ipsilateral PV stenosis/PVO and a CSI > or =75% require early and, when necessary, repeated pulmonary interventions for restoration of pulmonary flow and prevention of associated lung disease.
authors.affiliation: Department of Cardiovascular Medicine, Section of Cardiac Electrophysiology and Pacing, Cleveland Clinic, Cleveland, Ohio 44195, USA.
authors.forename: Luigi
authors.initials: L
authors.lastname: Di Biase
authors.forename: Tamer S
authors.initials: TS
authors.lastname: Fahmy
authors.forename: Oussama M
authors.initials: OM
authors.lastname: Wazni
authors.forename: Rong
authors.initials: R
authors.lastname: Bai
authors.forename: Dimpi
authors.initials: D
authors.lastname: Patel
authors.forename: Dhanunjaya
authors.initials: D
authors.lastname: Lakkireddy
authors.forename: Jennifer E
authors.initials: JE
authors.lastname: Cummings
authors.forename: Robert A
authors.initials: RA
authors.lastname: Schweikert
authors.forename: J David
authors.initials: JD
authors.lastname: Burkhardt
authors.forename: Claude S
authors.initials: CS
authors.lastname: Elayi
authors.forename: Mohamed
authors.initials: M
authors.lastname: Kanj
authors.forename: Lucie
authors.initials: L
authors.lastname: Popova
authors.forename: Subramanya
authors.initials: S
authors.lastname: Prasad
authors.forename: David O
authors.initials: DO
authors.lastname: Martin
authors.forename: Lourdes
authors.initials: L
authors.lastname: Prieto
authors.forename: Walid
authors.initials: W
authors.lastname: Saliba
authors.forename: Patrick
authors.initials: P
authors.lastname: Tchou
authors.forename: Mauricio
authors.initials: M
authors.lastname: Arruda
authors.forename: Andrea
authors.initials: A
authors.lastname: Natale
mesh_terms: D001281:Atrial Fibrillation / Q000628:therapy*; D017115:Catheter Ablation / Q000009:adverse effects*; D003251:Constriction, Pathologic; D006801:Humans; D011667:Pulmonary Veins; D011668:Pulmonary Veno-Occlusive Disease / Q000209:etiology*