The CASH (color, architecture, symmetry, and homogeneity) algorithm for dermoscopy.
BACKGROUND
The color, architecture, symmetry, and homogeneity (CASH) algorithm for dermoscopy includes a feature not used in prior algorithms, namely, architecture. Architectural order/disorder is derived from current concepts regarding the biology of benign versus malignant melanocytic neoplasms.


OBJECTIVE
We sought to evaluate the accuracy of the CASH algorithm.


METHODS
A total CASH score (TCS) was calculated for dermoscopic images of 325 melanocytic neoplasms. Sensitivity, specificity, diagnostic accuracy, and receiver operating characteristic curve analyses were performed by comparing the TCS with the histopathologic diagnoses for all lesions.


RESULTS
The mean TCS was 12.28 for melanoma, 7.62 for dysplastic nevi, and 5.24 for nondysplastic nevi. These differences were statistically significant (P < .001). A TCS of 8 or more yielded a sensitivity of 98% and specificity of 68% for the diagnosis of melanoma.


CONCLUSIONS
This is a single-evaluator pilot study. Additional studies are needed to verify the CASH algorithm.


CONCLUSIONS
The CASH algorithm can distinguish melanoma from melanocytic nevi with sensitivity and specificity comparable with other algorithms. Further study is warranted to determine its intraobserver and interobserver correlations.
Henning
J Scott
JS
Ronald O. Perelman Department of Dermatology, New York University School of Medicine and Sloan-Kettering Cancer Center, New York 10016, USA.
Dusza
Stephen W
SW
Wang
Steven Q
SQ
Marghoob
Ashfaq A
AA
Rabinovitz
Harold S
HS
Polsky
David
D
Kopf
Alfred W
AW
D000465:Algorithms; D019540:Area Under Curve; D003430:Cross-Sectional Studies; D046169:Dermoscopy / Q000379:methods / Q000592:standards*; D003937:Diagnosis, Differential; D008544:Melanocytes / Q000648:ultrastructure; D008545:Melanoma / Q000175:diagnosis / Q000648:ultrastructure*; D009508:Nevus, Pigmented / Q000151:congenital / Q000175:diagnosis / Q000648:ultrastructure; D010858:Pigmentation; D010865:Pilot Projects; D011237:Predictive Value of Tests; D012372:ROC Curve; D015203:Reproducibility of Results; D012720:Severity of Illness Index; D012878:Skin Neoplasms / Q000175:diagnosis / Q000648:ultrastructure*