title: Efficacy of two triple eradication regimens in children with Helicobacter pylori infection.
abstract: Triple therapy with bismuth subsalicylate, amoxicillin, metronidazole (BAM) or with omeprazole, amoxicillin, clarithromycin (OAC) has been commonly used for the eradication of Helicobacter pylori infection. We compared the efficacy of these triple therapies in children with H. pylori infection. We retrospectively analyzed results in 233 children with H. pylori infection and treated with OAC (n=141) or BAM (n=92). Overall eradication rates of triple therapy with OAC and BAM were 74% and 85%, respectively, which showed no statistical difference. Our study showed that the triple therapy with BAM was more effective for the first-line eradication of H. pylori infection in Korean children, but has no statistical difference with OAC regimen.
authors.affiliation: Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Songpa-Gu, Seoul, Korea.
authors.forename: Jungi
authors.initials: J
authors.lastname: Choi
authors.forename: Joo Young
authors.initials: JY
authors.lastname: Jang
authors.forename: Joon Sung
authors.initials: JS
authors.lastname: Kim
authors.forename: Hwa Young
authors.initials: HY
authors.lastname: Park
authors.forename: Yon Ho
authors.initials: YH
authors.lastname: Choe
authors.forename: Kyung Mo
authors.initials: KM
authors.lastname: Kim
mesh_terms: D000293:Adolescent; D000658:Amoxicillin / Q000008:administration & dosage*; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D001729:Bismuth / Q000008:administration & dosage*; D002648:Child; D002675:Child, Preschool; D017291:Clarithromycin / Q000008:administration & dosage*; D004338:Drug Combinations; D005260:Female; D016481:Helicobacter Infections / Q000188:drug therapy*; D016480:Helicobacter pylori / Q000187:drug effects*; D006801:Humans; D008297:Male; D008795:Metronidazole / Q000008:administration & dosage*; D009853:Omeprazole / Q000008:administration & dosage*; D009942:Organometallic Compounds / Q000008:administration & dosage*; D012189:Retrospective Studies; D012459:Salicylates / Q000008:administration & dosage*; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D004338:Drug Combinations; D009942:Organometallic Compounds; D012459:Salicylates; D008795:Metronidazole; C015715:bismuth subsalicylate; D000658:Amoxicillin; D017291:Clarithromycin; D009853:Omeprazole; D001729:Bismuth