The role of the cytoskeleton in neuromuscular junction formation.
The cytoskeleton plays a vital role in neuromuscular junction (NMJ) formation. It is responsible for shaping synaptic membrane into folds opposed to presynaptic active zones and anchoring acetylcholine receptors (AChRs) to the crest of the junctional folds. Acetylcholine receptors (AChRs) associate with the actin cytoskeleton, the disruption of which affects spontaneous and agrin-induced AChR clusters (Prives et al., 1982; Connolly, 1984; Peng and Phelan, 1984; Bloch, 1986; Dai et al., 2000). How AChRs are tethered to the actin cytoskeleton remains unclear.
Dobbins
G Clement
GC
Program of Developmental Neurobiology, Institute of Molecular Medicine and Genetics, Department of Neurology, Medical College of Georgia, Augusta, GA 30912, USA.
Zhang
Bin
B
Xiong
Wen C
WC
Mei
Lin
L
D000185:Actinin / Q000502:physiology; D000818:Animals; D003599:Cytoskeleton / Q000502:physiology*; D049030:Dystroglycans / Q000502:physiology; D009124:Muscle Proteins / Q000502:physiology; D009469:Neuromuscular Junction / Q000502:physiology*; D049411:Utrophin / Q000502:physiology
D009124:Muscle Proteins; D049411:Utrophin; C051609:peripheral membrane protein 43K; D000185:Actinin; D049030:Dystroglycans