title: Lactic acidosis in children with acute exacerbation of severe asthma.
abstract: This is a retrospective case series reporting lactic acidosis in four pediatric patients with acute severe asthma treated with nebulized beta2-agonists in a pediatric intensive care unit of a tertiary care teaching facility. During treatment with beta2-agonists, these patients developed lactic acidosis with a peak concentration of 5.2 to 13 mmol/l. Lactic acidosis improved within 24 h after discontinuation or decrease in the dosage of beta2-agonists. We conclude that the intensive use of beta2-agonists for acute severe asthma in children may be the primary and significant cause of lactic acidosis.
authors.forename: Pulin B
authors.initials: PB
authors.lastname: Koul
authors.forename: Milan
authors.initials: M
authors.lastname: Minarik
authors.forename: Balagangadhar R
authors.initials: BR
authors.lastname: Totapally
mesh_terms: D000140:Acidosis, Lactic / Q000139:chemically induced*; D000293:Adolescent; D000318:Adrenergic beta-Agonists / Q000009:adverse effects*; D000420:Albuterol / Q000009:adverse effects*; D001249:Asthma / Q000188:drug therapy*; D002648:Child; D006801:Humans; D008297:Male; D012189:Retrospective Studies
chemical_list: D000318:Adrenergic beta-Agonists; D000420:Albuterol