title: Small molecules keep mitotic kinases in check.
abstract: The remarkable progress in the discovery of small molecules that target protein kinases continues, and two recent reports have described alternative approaches to this task: homology modeling and phenotype-based screening. Compounds targeting the nucleotide binding pockets of polo-like kinases in particular provide significant new insights into the molecular mechanisms controlling cell-division phenotypes.
authors.affiliation: Department of Obstetrics and Gynecology, School of Medicine, J. W. Goethe-University, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany. strebhardt@em.uni-frankfurt.de
authors.forename: Klaus
authors.initials: K
authors.lastname: Strebhardt
mesh_terms: D001665:Binding Sites / Q000187:drug effects / Q000502:physiology; D008938:Mitosis / Q000187:drug effects / Q000502:physiology*; D047428:Protein Kinase Inhibitors / Q000737:chemistry* / Q000494:pharmacology; D011494:Protein Kinases / Q000378:metabolism*
chemical_list: D047428:Protein Kinase Inhibitors; D011494:Protein Kinases