title: SFK-STAT pathway: an alternative and important way to malignancies.
abstract: Signal transducers and activators of transcription (STAT) proteins play a crucial role in mediating signals from a diverse spectrum of cytokine receptors. STAT is thought to be activated by JAK family kinases (JFK) in many cytokine receptor signal pathways; however, recent studies have demonstrated an alternative pathway to activate STAT by Src family kinases (SFK) in growth factor receptor signal. We also observed STAT5 phosphorylation by Lyn, a member of SFK, in our two recent studies. We introduce these studies and review the literature of STAT activation by SFK and aberrant activation of STAT by oncogenic signals.
authors.affiliation: Department of Hematology and Oncology, Nagoya University, Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan. bun-hy@med.nagoya-u.ac.jp
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Hayakawa
authors.forename: Tomoki
authors.initials: T
authors.lastname: Naoe
mesh_terms: D000818:Animals; D002471:Cell Transformation, Neoplastic; D006801:Humans; D053612:Janus Kinases / Q000235:genetics / Q000502:physiology; D009154:Mutation; D010766:Phosphorylation; D050791:STAT Transcription Factors / Q000235:genetics / Q000502:physiology*; D050799:STAT5 Transcription Factor / Q000235:genetics / Q000502:physiology; D015398:Signal Transduction; D019061:src-Family Kinases / Q000235:genetics / Q000502:physiology*
chemical_list: D050791:STAT Transcription Factors; D050799:STAT5 Transcription Factor; D053612:Janus Kinases; C060902:lyn protein-tyrosine kinase; D019061:src-Family Kinases