Chemotaxis: Cofilin in the driver's seat.
A cell responds to a chemotactic signal by activating actin polymerization and forming a protrusion oriented towards the source. Recent work shows that the activity of cofilin, a protein that creates new barbed ends for actin filament elongation, amplifies and specifies the direction of the response in carcinoma cells.
Hitchcock-Degregori
Sarah E
SE
Department of Neuroscience and Cell Biology, Robert Wood Johnson Medical School, 675 Hoes Lane West, Piscataway, New Jersey 08854-8021, USA. hitchcoc@umdnj.edu
D008841:Actin Cytoskeleton / Q000378:metabolism; D051339:Actin Depolymerizing Factors / Q000502:physiology*; D000199:Actins / Q000378:metabolism*; D000818:Animals; D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology*; D002630:Chemotactic Factors / Q000378:metabolism; D002633:Chemotaxis / Q000502:physiology*; D004815:Epidermal Growth Factor / Q000378:metabolism; D054461:Lim Kinases; D009362:Neoplasm Metastasis; D011494:Protein Kinases / Q000378:metabolism; D010738:Type C Phospholipases / Q000378:metabolism
D051339:Actin Depolymerizing Factors; D000199:Actins; D002630:Chemotactic Factors; D004815:Epidermal Growth Factor; D011494:Protein Kinases; D054461:Lim Kinases; D010738:Type C Phospholipases