Argentine population genetic structure: large variance in Amerindian contribution.
Argentine population genetic structure was examined using a set of 78 ancestry informative markers (AIMs) to assess the contributions of European, Amerindian, and African ancestry in 94 individuals members of this population. Using the Bayesian clustering algorithm STRUCTURE, the mean European contribution was 78%, the Amerindian contribution was 19.4%, and the African contribution was 2.5%. Similar results were found using weighted least mean square method: European, 80.2%; Amerindian, 18.1%; and African, 1.7%. Consistent with previous studies the current results showed very few individuals (four of 94) with greater than 10% African admixture. Notably, when individual admixture was examined, the Amerindian and European admixture showed a very large variance and individual Amerindian contribution ranged from 1.5 to 84.5% in the 94 individual Argentine subjects. These results indicate that admixture must be considered when clinical epidemiology or case control genetic analyses are studied in this population. Moreover, the current study provides a set of informative SNPs that can be used to ascertain or control for this potentially hidden stratification. In addition, the large variance in admixture proportions in individual Argentine subjects shown by this study suggests that this population is appropriate for future admixture mapping studies.
Seldin
Michael F
MF
Rowe Program in Human Genetics, Department of Biological Chemistry, University of California Davis, Davis, CA 95616, USA. mfseldin@ucdavis.edu
Tian
Chao
C
Shigeta
Russell
R
Scherbarth
Hugo R
HR
Silva
Gabriel
G
Belmont
John W
JW
Kittles
Rick
R
Gamron
Susana
S
Allevi
Alberto
A
Palatnik
Simon A
SA
Alvarellos
Alejandro
A
Paira
Sergio
S
Caprarulo
Cesar
C
Guillerón
Carolina
C
Catoggio
Luis J
LJ
Prigione
Cristina
C
Berbotto
Guillermo A
GA
García
Mercedes A
MA
Perandones
Carlos E
CE
Pons-Estel
Bernardo A
BA
Alarcon-Riquelme
Marta E
ME
D044466:Asian People / Q000235:genetics; D001499:Bayes Theorem; D044383:Black People / Q000235:genetics; D005787:Gene Frequency; D005819:Genetic Markers; D014644:Genetic Variation; D005828:Genetics, Population; D006801:Humans; D007199:Indians, South American / Q000235:genetics*; D017058:Mexican Americans / Q000235:genetics; D044465:White People / Q000235:genetics
D005819:Genetic Markers