seco-Cycloartane triterpenes from Gardenia aubryi.
Three new 3,4-seco-cycloartanes, secaubryenol (1), secaubrytriol (2), and secaubryolide (3), were isolated from an exudate collected on the aerial parts of Gardenia aubryi, in addition to the known (24S)-cycloartane-24,25-diol-3-one, coccinetane A, herbacetin 3,8-dimethyl ether, hibiscetin 3,8,3',4'-tetramethyl ether, and conyzatin. The structures of 1 and 2 were established by mass spectrometry and NMR experiments, while the relative configuration of 2 was defined unequivocally using X-ray crystallography. The in vitro cytotoxic activity of compounds 1-3 was evaluated against four human solid tumor cell lines.
Grougnet
Raphaël
R
Laboratory of Pharmacognosy and Natural Products Chemistry, Department of Pharmacy, University of Athens, Panepistimiopolis-Zografou, Athens GR-15771, Greece.
Magiatis
Prokopios
P
Mitaku
Sofia
S
Loizou
Stella
S
Moutsatsou
Paraskevi
P
Terzis
Aris
A
Cabalion
Pierre
P
Tillequin
François
F
Michel
Sylvie
S
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D032062:Gardenia / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D008968:Molecular Conformation; D015394:Molecular Structure; D009510:New Caledonia; D010946:Plants, Medicinal / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D000972:Antineoplastic Agents, Phytogenic; D014315:Triterpenes; C516505:secaubryenol; C516507:secaubryolide; C516506:secaubrytriol; C085352:cycloartane