title: Acute renal failure associated with use of inhaled tobramycin for treatment of chronic airway colonization with Pseudomonas aeruginosa.
abstract: Aminoglycoside nephrotoxicity is a well-known clinical entity that complicates the course of infectious diseases treated under this antibiotic regime. Recently, a new administration form of tobramycin, inhaled tobramycin (TOBI), has been approved to improve the antibacterial activity and reduce nephrotoxicity. We describe the clinical case of a 73-year-old woman with chronic-obstructive pulmonary disease (COPD) who developed acute renal failure (ARF) after using TOBI. Clinical presentation and biochemical parameters were compatible with aminoglycoside-induced renal failure. Based on the clinical findings presented here, a surveillance program should be established to monitor the presence of factors predisposing to renal failure, and to measure serum levels of tobramycin.
authors.affiliation: Nephrology Department, "Marques de Valdecilla" Hospital, University of Cantabria, Santander, Cantabria, Spain.
authors.forename: M J
authors.initials: MJ
authors.lastname: Izquierdo
authors.forename: C
authors.initials: C
authors.lastname: Gomez-Alamillo
authors.forename: F
authors.initials: F
authors.lastname: Ortiz
authors.forename: E R
authors.initials: ER
authors.lastname: Calabia
authors.forename: J C
authors.initials: JC
authors.lastname: Ruiz
authors.forename: A L M
authors.initials: AL
authors.lastname: de Francisco
authors.forename: M
authors.initials: M
authors.lastname: Arias
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced*; D000280:Administration, Inhalation; D000368:Aged; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects*; D015169:Colony Count, Microbial; D005260:Female; D006801:Humans; D011552:Pseudomonas Infections / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy*; D011550:Pseudomonas aeruginosa / Q000302:isolation & purification*; D029424:Pulmonary Disease, Chronic Obstructive / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy*; D013902:Radiography, Thoracic; D014031:Tobramycin / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D000900:Anti-Bacterial Agents; D014031:Tobramycin