Synthesis and activity of Combretastatin A-4 analogues: 1,2,3-thiadiazoles as potent antitumor agents.
A series of 4,5-disubstitute-1,2,3-thiadiazole compounds were designed and synthesized as potent anticancer agents, some of them exhibited excellent in vitro and in vivo inhibitory activity.
Wu
Maojiang
M
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, SIBS, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, PR China.
Sun
Qiming
Q
Yang
Chunhao
C
Chen
Dongdong
D
Ding
Jian
J
Chen
Yi
Y
Lin
Liping
L
Xie
Yuyuan
Y
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis* / Q000494:pharmacology*; D002453:Cell Cycle / Q000187:drug effects; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D029765:Combretum / Q000737:chemistry; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007202:Indicators and Reagents; D051379:Mice; D009368:Neoplasm Transplantation; D011108:Polymers / Q000737:chemistry; D012510:Sarcoma 180 / Q000188:drug therapy / Q000473:pathology / Q000648:ultrastructure; D013267:Stilbenes / Q000138:chemical synthesis* / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013830:Thiadiazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D014404:Tubulin / Q000737:chemistry
D000972:Antineoplastic Agents, Phytogenic; D007202:Indicators and Reagents; D011108:Polymers; D013267:Stilbenes; D013830:Thiadiazoles; D014404:Tubulin; C058728:fosbretabulin