title: Assessment of endoleak significance after endovascular repair of abdominal aortic aneurysms: a lumped parameter model.
abstract: The outcome of endovascular repair of abdominal aortic aneurysms (AAAs) is greatly compromised by the possible occurrence of endoleak. Previously, the causes and effects of endoleak on a patient-specific basis have mainly been investigated in experimental studies. In order to both reconcile and physically substantiate the various experimental findings, a lumped parameter model of an incompletely excluded AAA was developed. After experimental validation, the model was applied to study the effects on the intrasac pressure of the degree of endoleak, the degree of stent-graft compliance, and the resistance of a possible outflow tract formed by a branching vessel. It is concluded that the presence of endoleak leads to elevated intrasac pressure, the mean of which is mainly governed by the outflow tract resistance, while the pulse pressure is governed by both the endoleak resistance and the stent-graft compliance. Based on the agreement of the current results with previous findings, it is further concluded that the lumped parameter modelling method provides a useful numerical tool for validating experimental endoleak studies.
authors.affiliation: Department of Biomedical Engineering, Eindhoven University of Technology, The Netherlands. b.j.m.wolters@tue.nl
authors.forename: B J B M
authors.initials: BJ
authors.lastname: Wolters
authors.forename: M
authors.initials: M
authors.lastname: Emmer
authors.forename: M C M
authors.initials: MC
authors.lastname: Rutten
authors.forename: G W H
authors.initials: GW
authors.lastname: Schurink
authors.forename: F N
authors.initials: FN
authors.lastname: van de Vosse
mesh_terms: D000465:Algorithms; D001011:Aorta / Q000473:pathology; D017544:Aortic Aneurysm, Abdominal / Q000601:surgery*; D019917:Blood Vessel Prosthesis Implantation / Q000009:adverse effects; D003198:Computer Simulation; D004867:Equipment Design; D006801:Humans; D008955:Models, Cardiovascular; D015233:Models, Statistical; D008962:Models, Theoretical; D011183:Postoperative Complications / Q000209:etiology*; D011312:Pressure; D012984:Software; D015607:Stents; D013997:Time Factors; D016896:Treatment Outcome