title: Effects of dietary supplements of selenium, vitamin E or combinations of the two on antibody responses of broilers.
abstract: 1. The effects of selenium and vitamin E supplementation on some immune parameters were investigated in broilers. 2. Broiler chicks were fed on maize-soybean diets with different concentrations of vitamin E (0-200 mg/kg) and selenium (0-0.2 mg/kg diet) either alone or in combinations from 1 to 42 d of age. 3. Chicks were immunised against Newcastle disease virus (NDV) vaccine at 21 d of age and haemagglutination inhibition (HI) titres were determined after 10 d. 4. Chicks receiving supplements of 200 mg vitamin E/kg and 0.2 mg selenium/kg produced significantly higher HI antibody titres. This was associated with an increased serum concentration of total immunoglobulins and circulatory immune complexes. 5. The chicks given 200 mg vitamin E/kg and 0.2 mg selenium/kg had significantly heavier spleen and bursa. 6. These results suggested that vitamin E and selenium have synergistic effects on immune responses.
authors.affiliation: College of Veterinary Science, Punjab Agricultural University, Ludhiana, Punjab, India.
authors.forename: H
authors.initials: H
authors.lastname: Singh
authors.forename: S
authors.initials: S
authors.lastname: Sodhi
authors.forename: R
authors.initials: R
authors.lastname: Kaur
mesh_terms: D000821:Animal Feed / Q000032:analysis; D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D000936:Antigen-Antibody Complex / Q000097:blood*; D001835:Body Weight; D002645:Chickens / Q000097:blood / Q000276:immunology*; D004032:Diet / Q000662:veterinary; D019587:Dietary Supplements; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D005260:Female; D006385:Hemagglutination Inhibition Tests / Q000662:veterinary; D007136:Immunoglobulins / Q000097:blood*; D008221:Lymphoid Tissue / Q000187:drug effects; D008297:Male; D012643:Selenium / Q000008:administration & dosage / Q000494:pharmacology*; D014810:Vitamin E / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D000936:Antigen-Antibody Complex; D007136:Immunoglobulins; D014810:Vitamin E; D012643:Selenium