title: seco-Cycloartane triterpenes from Gardenia aubryi.
abstract: Three new 3,4-seco-cycloartanes, secaubryenol (1), secaubrytriol (2), and secaubryolide (3), were isolated from an exudate collected on the aerial parts of Gardenia aubryi, in addition to the known (24S)-cycloartane-24,25-diol-3-one, coccinetane A, herbacetin 3,8-dimethyl ether, hibiscetin 3,8,3',4'-tetramethyl ether, and conyzatin. The structures of 1 and 2 were established by mass spectrometry and NMR experiments, while the relative configuration of 2 was defined unequivocally using X-ray crystallography. The in vitro cytotoxic activity of compounds 1-3 was evaluated against four human solid tumor cell lines.
authors.affiliation: Laboratory of Pharmacognosy and Natural Products Chemistry, Department of Pharmacy, University of Athens, Panepistimiopolis-Zografou, Athens GR-15771, Greece.
authors.forename: Raphaël
authors.initials: R
authors.lastname: Grougnet
authors.forename: Prokopios
authors.initials: P
authors.lastname: Magiatis
authors.forename: Sofia
authors.initials: S
authors.lastname: Mitaku
authors.forename: Stella
authors.initials: S
authors.lastname: Loizou
authors.forename: Paraskevi
authors.initials: P
authors.lastname: Moutsatsou
authors.forename: Aris
authors.initials: A
authors.lastname: Terzis
authors.forename: Pierre
authors.initials: P
authors.lastname: Cabalion
authors.forename: François
authors.initials: F
authors.lastname: Tillequin
authors.forename: Sylvie
authors.initials: S
authors.lastname: Michel
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D032062:Gardenia / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D008968:Molecular Conformation; D015394:Molecular Structure; D009510:New Caledonia; D010946:Plants, Medicinal / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D014315:Triterpenes; C516505:secaubryenol; C516507:secaubryolide; C516506:secaubrytriol; C085352:cycloartane