title: Liquid and solid gastric emptying in adults treated for Hirschsprung's disease during early childhood.
abstract: OBJECTIVE
  Dysmotility of the upper gastrointestinal tract has been reported in children with Hirschsprung's disease. In the present study, gastric emptying was studied in adult patients with Hirschsprung's disease to elucidate whether there is a persisting involvement of the upper gastrointestinal tract in this group of patients.
  
  
  METHODS
  Gastric emptying of caloric liquids and solids was studied in 16 adult patients with surgically treated Hirschsprung's disease during early childhood and in age-matched controls. To examine liquid emptying, the paracetamol absorption test was applied using a meal containing glucose, lactose, maize oil, water (2020 kJ) and paracetamol. To examine solid emptying, the 13C gastric emptying breath test was applied using a meal containing white bread, margarine, a one-egg omelette (1050 kJ) and [13C]-octanoic acid. Gastrointestinal symptoms were recorded according to a standardized questionnaire.
  
  
  RESULTS
  For liquid meal emptying, the time until emptying commenced was 8.1+/-1.9 and 2.9+/-0.9 min (mean+/-SE) in patients and controls, respectively (p=0.02). Thereafter, the first 25% of the meal emptied in 6.8+/-0.8 and 12.1+/-1.1 min in patients and controls, respectively (p=0.0005). The overall emptying rate tended to be delayed in patients compared with controls (p=0.06). For the solid meal, a delay in emptying was evident (p=0.02). The patients reported more symptoms from the upper gastrointestinal tract than the controls, but the symptoms were not significantly related to the emptying pathology demonstrated.
  
  
  CONCLUSIONS
  The present study demonstrates that adult patients with Hirschsprung's disease have an abnormal pattern of gastric emptying, indicating persisting involvement of the upper gastrointestinal tract.
authors.affiliation: Department of Medicine, Ullevål University Hospital, Oslo, Norway. a.w.medhus@medisin.uio.no
authors.forename: Asle W
authors.initials: AW
authors.lastname: Medhus
authors.forename: Kristin
authors.initials: K
authors.lastname: Bjørnland
authors.forename: Ragnhild
authors.initials: R
authors.lastname: Emblem
authors.forename: Einar
authors.initials: E
authors.lastname: Husebye
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D001944:Breath Tests; D002648:Child; D005260:Female; D005502:Food; D005746:Gastric Emptying; D006627:Hirschsprung Disease / Q000097:blood / Q000503:physiopathology*; D006801:Humans; D007328:Insulin / Q000097:blood; D008297:Male; D008892:Milk; D012996:Solutions
chemical_list: D001786:Blood Glucose; D007328:Insulin; D012996:Solutions