Maintaining hematopoietic stem cells in the vascular niche.
In this issue of Immunity, Sugiyama et al. (2006) provide evidence that most bone-marrow hematopoietic stem cells (HSCs) reside in vascular niches containing reticular cells that secrete CXCL12, a chemokine that promotes HSC maintenance.
Kiel
Mark J
MJ
Howard Hughes Medical Institute, Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, USA.
Morrison
Sean J
SJ
D000818:Animals; D001853:Bone Marrow / Q000098:blood supply / Q000648:ultrastructure*; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D006413:Hematopoietic System / Q000166:cytology*; D006801:Humans; D010006:Osteoblasts / Q000166:cytology