Reversible binding of heme to proteins in cellular signal transduction.
Heme plays critical roles in numerous biological phenomena. Recent evidence has uncovered a new role of heme in cellular signal transduction, and its mechanism involves reversible binding of heme to proteins. This Account highlights the novel function of heme as an intracellular messenger in the regulation of gene expression and ion channel function.
Hou
Shangwei
S
Department of Physiology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Reynolds
Mark F
MF
Horrigan
Frank T
FT
Heinemann
Stefan H
SH
Hoshi
Toshinori
T
D000818:Animals; D005786:Gene Expression Regulation; D006418:Heme / Q000096:biosynthesis / Q000737:chemistry / Q000378:metabolism*; D006420:Hemeproteins / Q000737:chemistry / Q000378:metabolism; D007473:Ion Channels / Q000378:metabolism; D011485:Protein Binding; D015398:Signal Transduction
D006420:Hemeproteins; D007473:Ion Channels; D006418:Heme