Vascular endothelium summary statement I: Health promotion and chronic disease prevention.
The endothelium can be considered a discrete organ with pathophysiologic implications and as such has both diagnostic and therapeutic possibilities. It is essential for the normal function of the cardiovascular, cerebrovascular, renovascular, and pulmonary vascular system. The endothelium is directly involved in the development and progression of heart disease, stroke, peripheral vascular disease, venous thrombosis, insulin resistance, diabetes, chronic kidney failure, tumor growth, metastases and adverse reproductive outcomes for both the mother and her newborn child. Consequently the endothelium represents an objective biological determinant on which to base new multidisciplinary prevention and health promotion strategies. This summary statement suggests some possible avenues for clinical and public health research.
Hooper
W Craig
WC
National Center for Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention (CDC), Mailstop DO-2, 1600 Clifton Road, Atlanta, GA 30333, USA. chooper@cdc.gov
Catravas
John D
JD
Heistad
Donald D
DD
Sessa
William C
WC
Mensah
George A
GA
D000818:Animals; D035843:Biomedical Research / Q000639:trends; D002318:Cardiovascular Diseases / Q000209:etiology* / Q000503:physiopathology / Q000517:prevention & control*; D002908:Chronic Disease; D004059:Diffusion of Innovation; D004730:Endothelium, Vascular / Q000503:physiopathology*; D014943:Global Health; D015438:Health Behavior; D006293:Health Promotion; D006801:Humans; D011322:Primary Prevention