title: Reduction in orofacial clefts following folic acid fortification of the U.S. grain supply.
abstract: BACKGROUND
  Folic acid fortification in the United States became mandatory January 1, 1998, to reduce the occurrence of neural tube defects (NTDs). We evaluated the impact of folic acid fortification on orofacial clefts using United States birth certificate data for 45 states and the District of Columbia.
  
  
  METHODS
  Prevalence ratios (PRs) were calculated comparing orofacial cleft prevalence among births prefortification (1/1990-12/1996) and postfortification (10/1998-12/2002), based on fortification status at conception. The JoinPoint Regression Program and exponentially weighted moving average charts (EWMA) were used to assess the timing of any statistically significant changes in prevalence. Data were stratified by maternal race/ethnicity, age, smoking, and timing of prenatal care.
  
  
  RESULTS
  Orofacial clefts declined following folic acid fortification (PR=0.94; 95% CI: 0.92-0.96). The EWMA chart flagged a significant decrease in the fourth quarter of 1998. The JoinPoint graph had one change in slope, with a significant quarterly percent change (-0.34) between 1996 and 2002. The decline in orofacial clefts occurred in non-Hispanic Whites but not other racial/ethnic groups, nonsmokers but not women who reported smoking during pregnancy, and women who received prenatal care in the first trimester but not women who began receiving care later in pregnancy.
  
  
  CONCLUSIONS
  Folic acid fortification in the United States was associated with a small decrease in orofacial cleft prevalence, with the timing of the decline consistent with the introduction of fortification. The decline is much smaller than that observed for NTDs, but nonetheless suggests an additional benefit of this public health intervention.
authors.affiliation: National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA. myazdy@cdc.gov
authors.forename: Mahsa M
authors.initials: MM
authors.lastname: Yazdy
authors.forename: Margaret A
authors.initials: MA
authors.lastname: Honein
authors.forename: Jian
authors.initials: J
authors.lastname: Xing
mesh_terms: D002971:Cleft Lip / Q000453:epidemiology* / Q000517:prevention & control*; D002972:Cleft Palate / Q000453:epidemiology* / Q000517:prevention & control*; D002523:Edible Grain; D005260:Female; D005492:Folic Acid / Q000627:therapeutic use*; D005523:Food Supply; D005527:Food, Fortified; D006801:Humans; D016742:Preconception Care; D011247:Pregnancy; D011295:Prenatal Care; D015995:Prevalence; D044469:Racial Groups; D014481:United States
chemical_list: D005492:Folic Acid