When CDK1 rides the telomere cycle.
Reconstitution of telomeric DNA at each cell division implies the coordination of DNA semiconservative replication with several processing events still poorly understood. Two reports published recently in Molecular Cell show that a cell-cycle cyclin-dependent kinase, Cdk1p, is required to create the cell-cycle-regulated overhang ().
Teixeira
M Teresa
MT
Laboratoire de Biologie Moléculaire de la Cellule of Ecole Normale Supérieure de Lyon, UMR CNRS/INRA/ENS, IFR 128 BioSciences Lyon Gerland, 46 Allée d'Italie, 69364 Lyon Cedex 07, France.
Gilson
Eric
E
D016203:CDC2 Protein Kinase / Q000378:metabolism*; D017489:CDC28 Protein Kinase, S cerevisiae / Q000378:metabolism*; D002453:Cell Cycle / Q000502:physiology*; D018797:Cell Cycle Proteins / Q000378:metabolism*; D008954:Models, Biological; D012441:Saccharomyces cerevisiae; D016615:Telomere / Q000378:metabolism*
D018797:Cell Cycle Proteins; D016203:CDC2 Protein Kinase; D017489:CDC28 Protein Kinase, S cerevisiae