Anti-tumor-initiating effects of monascin, an azaphilonoid pigment from the extract of Monascus pilosus fermented rice (red-mold rice).
Monascin (1) constitutes one of the azaphilonoid pigments in the extracts of Monascus pilosus-fermented rice (red-mold rice). Compound 1 was evaluated for its anti-tumor-initiating activity via oral administration on the two-stage carcinogenesis of mouse skin tumor induced by peroxynitrite (ONOO-; PN) or by ultraviolet light B (UVB) as an initiator and 12-O-tetradecanoylphorbol-13-acetate (TPA) as a promoter. Compound 1 exhibited marked inhibitory activity on both PN- and UVB-induced mouse skin carcinogenesis tests. These findings suggest that compound 1 may be valuable as potential cancer chemopreventive agent in chemical and environmental carcinogenesis.
Akihisa
Toshihiro
T
College of Science and Technology, Nihon University, 1-8 Kanda Surugadai, Chiyoda-ku, Tokyo 101-8308, Japan. akihisa@chem.cst.nihon-u.ac.jp
Tokuda
Harukuni
H
Ukiya
Motohiko
M
Kiyota
Ayaka
A
Yasukawa
Ken
K
Sakamoto
Naoyuki
N
Kimura
Yumiko
Y
Suzuki
Takashi
T
Takayasu
Junko
J
Nishino
Hoyoku
H
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D005260:Female; D006575:Heterocyclic Compounds, 3-Ring / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D051379:Mice; D018632:Mice, Inbred SENCAR; D015394:Molecular Structure; D032741:Monascus / Q000378:metabolism*; D012275:Oryza / Q000378:metabolism* / Q000382:microbiology*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D012878:Skin Neoplasms / Q000139:chemically induced / Q000473:pathology*; D013047:Specific Pathogen-Free Organisms; D013997:Time Factors
D000970:Antineoplastic Agents; D006575:Heterocyclic Compounds, 3-Ring; D010936:Plant Extracts; C517880:monascin