Interferon receptor expression in multiple sclerosis patients.
To determine the gene expression of IFNAR1, IFNAR2 and MxA protein and the association with IFNbeta treatment response in MS patients. MS patients treated with IFNbeta had a significant decrease in IFNAR1 and IFNAR2 expression, and a significant increase in MxA compared to non-treated patients and healthy controls. Also, those patients who had a good response to treatment had a significant decrease in IFNAR1 and IFNAR2 expression compared to non-responders, non-treated patients and healthy controls. IFNbeta influences the expression of its receptors, and is greater in patients who respond to IFNbeta treatment. This down-regulation could be indicative of the response to IFNbeta.
Oliver
Begoña
B
Research Laboratory, Carlos Haya Hospital, Málaga, Spain.
Mayorga
Cristobalina
C
Fernández
Victoria
V
Leyva
Laura
L
León
Antonio
A
Luque
Gloria
G
López
Juan C
JC
Tamayo
Jose A
JA
Pinto-Medel
Maria J
MJ
de Ramon
Enrique
E
Blanco
Eva
E
Alonso
Ana
A
Fernández
Oscar
O
D000328:Adult; D005260:Female; D005786:Gene Expression Regulation / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D016899:Interferon-beta / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000188:drug therapy / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism; D017471:Receptors, Interferon / Q000235:genetics / Q000378:metabolism*; D020133:Reverse Transcriptase Polymerase Chain Reaction / Q000379:methods
D012333:RNA, Messenger; D017471:Receptors, Interferon; D016899:Interferon-beta