title: Pyoderma vegetans associated with severe psoriatic arthritis: good response to etanercept.
abstract: Pyoderma vegetans (PV) is an inflammatory dermatosis, characterized clinically by large exudative vegetating plaques, and histopathologically by epidermal pseudoepitheliomatous hyperplasia and dense inflammatory infiltrates. Although PV is a very rare condition, it is a chronic disorder that may accompany any systemic process that compromises immunity. Treatment is very difficult, and correction of predisposing causes may be useful. We present a 49-year-old woman affected by severe psoriatic arthritis since she was 19, with giant verrucous plaques on her lower limbs that had worsened progressively during the last 15 years. After ruling out other vegetating cutaneous disorders, PV was diagnosed in association with psoriasis. Despite numerous previous systemic and topical therapeutic attempts no response was observed. Etanercept was introduced, which resulted in a marked improvement within 3 weeks. Herein, we report a diagnostic and therapeutic challenge of the first case of PV associated with psoriasis that presented a good response to etanercept.
authors.affiliation: Department of Dermatology, Hospital Clínic de Barcelona, Barcelona University, Barcelona, Spain. criscarrer@yahoo.es
authors.forename: Cristina
authors.initials: C
authors.lastname: Carrera
authors.forename: Jose M
authors.initials: JM
authors.lastname: Mascaró
authors.forename: Juan A
authors.initials: JA
authors.lastname: Moreno-Romero
authors.forename: Pilar
authors.initials: P
authors.lastname: Iranzo
authors.forename: Josep
authors.initials: J
authors.lastname: Palou
authors.forename: Esther
authors.initials: E
authors.lastname: Zamora
authors.forename: Carmen
authors.initials: C
authors.lastname: Herrero
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D015535:Arthritis, Psoriatic / Q000150:complications* / Q000188:drug therapy; D001706:Biopsy; D000068800:Etanercept; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007074:Immunoglobulin G / Q000627:therapeutic use*; D008875:Middle Aged; D011711:Pyoderma / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D018124:Receptors, Tumor Necrosis Factor / Q000627:therapeutic use*; D011993:Recombinant Fusion Proteins; D012867:Skin / Q000473:pathology
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D007074:Immunoglobulin G; D018124:Receptors, Tumor Necrosis Factor; D011993:Recombinant Fusion Proteins; D000068800:Etanercept