title: The association between body size, prostate volume and prostate-specific antigen.
abstract: Increasing prostate volume contributes to urinary tract symptoms and may obscure prostate cancer detection. We investigated the association between obesity and prostate volume, prostate-specific antigen (PSA) and PSA density among 753 men referred for prostate biopsy. Among men with a negative biopsy, prostate volume significantly increased approximately 25% from the lowest to highest body mass index (BMI), waist or hip circumference or height categories. PSA was 0.7 ng/ml lower with a high waist-to-hip ratio. These associations were less consistent among subjects diagnosed with high-grade prostatic intraepithelial neoplasia or cancer. Our data suggest that obesity and height are independently associated with prostate volume..
authors.affiliation: Vanderbilt Epidemiology Center, Division of Internal Medicine and Public Health, Vanderbilt University Medical Center, Nashville, TN 37232-8300, USA. jay.fowke@vanderbilt.edu
authors.forename: J H
authors.initials: JH
authors.lastname: Fowke
authors.forename: S S
authors.initials: SS
authors.lastname: Motley
authors.forename: M S
authors.initials: MS
authors.lastname: Cookson
authors.forename: R
authors.initials: R
authors.lastname: Concepcion
authors.forename: S S
authors.initials: SS
authors.lastname: Chang
authors.forename: M L
authors.initials: ML
authors.lastname: Wills
authors.forename: J A
authors.initials: JA
authors.lastname: Smith
mesh_terms: D000005:Abdomen / Q000033:anatomy & histology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015992:Body Mass Index; D049628:Body Size; D006801:Humans; D008297:Male; D008875:Middle Aged; D011467:Prostate / Q000033:anatomy & histology*; D017430:Prostate-Specific Antigen / Q000032:analysis*; D011470:Prostatic Hyperplasia / Q000473:pathology*; D049629:Waist-Hip Ratio
chemical_list: D017430:Prostate-Specific Antigen