Decreased expression of tumor protein p53-induced nuclear protein 1 (TP53INP1) in breast carcinoma.
BACKGROUND
Tumor protein p53-induced nuclear protein 1 (TP53INP1) is a stress-induced protein and plays a role in cell cycle arrest and p53-mediated apoptosis. In this study, TP53INP1 expression in human breast carcinoma was investigated.


METHODS
TP53INP1 and aberrant p53 expression were investigated immunohistochemically in 81 cases of breast carcinoma.


RESULTS
Diffuse and intense TP53INP1 expression was observed in the normal mammary gland. Decreased TP53INP1 expression was found in 45 cases (55.6%) of breast carcinoma. The TP53INP1 expression level was inversely linked to tumor size, positive lymph node metastasis, high histological grade and aberrant p53 expression.


CONCLUSIONS
Decreased expression of TP53INP1 is involved in breast carcinoma progression.
Ito
Yasuhiro
Y
Department of Surgery, Kuma Hospital, 8-2-35, Shimoyamate-Dori, Chuo-ku, Kobe City, 650-0011, Japan. ito01@kuma-h.or.jp
Motoo
Yoshiharu
Y
Yoshida
Hiroshi
H
Iovanna
Juan Lucio
JL
Takamura
Yuuki
Y
Miya
Akihiro
A
Kuma
Kanji
K
Miyauchi
Akira
A
D001943:Breast Neoplasms / Q000235:genetics*; D002352:Carrier Proteins / Q000235:genetics*; D005260:Female; D006360:Heat-Shock Proteins / Q000235:genetics*; D006801:Humans; D007150:Immunohistochemistry
D002352:Carrier Proteins; D006360:Heat-Shock Proteins; C429767:TP53INP1 protein, human