title: Dose distribution for endovascular brachytherapy using Ir-192 sources: comparison of Monte Carlo calculations with radiochromic film measurements.
abstract: An analysis of Ir-192 source distribution using the Monte Carlo method and radiochromic film experiments for endovascular brachytherapy is presented. Three different source possibilities, namely, mHDR Ir-192 sources with 5 mm and 2.5 mm step sizes and Ir-192 seed sources with 1 mm air gap are investigated to obtain uniform radial dose distribution throughout the treatment area. From this study, it is inferred that mHDR Ir-192 sources with 2.5 mm step size are effective for getting dose uniformity. Hence, different restenosis geometries, namely, linear, dumb bell and hairpin, are simulated with 2.5 mm step size, 15 mHDR Ir-192 sources using the Monte Carlo technique and the results are compared experimentally by using radiochromic films. The results from both methods agreed to within 7%. Further, it is also inferred that for the dosimetry of endovascular brachytherapy, the film dosimetry may be considered adequate, even if the film calibration is time consuming and requires adequate dosimetric procedures.
authors.affiliation: Division of Medical Physics and Lasers, Department of Physics, Anna University, Chennai 600 025, India.
authors.forename: C S
authors.initials: CS
authors.lastname: Sureka
authors.forename: C Sunil
authors.initials: CS
authors.lastname: Sunny
authors.forename: K V
authors.initials: KV
authors.lastname: Subbaiah
authors.forename: P
authors.initials: P
authors.lastname: Aruna
authors.forename: S
authors.initials: S
authors.lastname: Ganesan
mesh_terms: D001918:Brachytherapy / Q000295:instrumentation* / Q000379:methods*; D002138:Calibration; D003327:Coronary Disease / Q000532:radiotherapy*; D004307:Dose-Response Relationship, Radiation; D005373:Film Dosimetry / Q000379:methods*; D006801:Humans; D007496:Iridium Radioisotopes / Q000627:therapeutic use*; D009010:Monte Carlo Method; D019047:Phantoms, Imaging; D011874:Radiometry / Q000379:methods*; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted; D014962:X-Ray Film
chemical_list: D007496:Iridium Radioisotopes