title: [Chemical destruction of sacral nerve roots by alcohol injection for the treatment of overactive bladder].
abstract: BACKGROUND
  This study retrospectively reviewed the value of alcohol injection of sacral nerve roots after a lidocaine test in two indications: detrusor instability-detrusor hyperactivity syndrome and cystalgia.
  
  
  METHODS
  Single-centre retrospective study from January 1992 to March 2003. Twenty-eight patients (1 man, 27 women) were admitted to the urology department for lidocaine test injection because of detrusor hyperactivity 24 cases (idiopathic = 13, neurological = 11), and cystalgia in another 4 cases.
  
  
  RESULTS
  After the lidocaine test, infiltration of the sacral nerve roots (bilateral S3) by 70% alcohol was performed in 24/28 cases. The therapeutic effect was assessed at 1 month: 14 out of 24 patients reported that they were globally improved by the alcohol injection. The mean duration of the therapeutic effect was 3.8 months. In the longer term, only one of the 14 patients initially improved did not subsequently experience deterioration of the clinical features (with a follow-up of 8 months). A second alcohol injection was performed in 5/28 patients, with a positive result in only one case (4%).
  
  
  RESULTS
  6/24 (25%) patients developed lower limb pain that resolved over 2 to 3 months; 3/24 (12%) presented immediate postoperative urinary retention (that persisted in the long term in 1 case); 1/24 (4%) presented cicatricial anal incontinence.
  
  
  CONCLUSIONS
  Alcohol injection of sacral nerve roots is a simple and inexpensive technique, but is associated with morbidity, and has inconstant and only transient effects. It can only be considered exceptionally in highly selected cases when no more effective treatments are available, such as botulinum toxin injection or sacral nerve root neuromodulation.
authors.affiliation: Service d'Urologie, Hôpital Henry Gabrielle, Saint Genis Laval, France.
authors.forename: Mikael
authors.initials: M
authors.lastname: Hoch
authors.forename: Albert
authors.initials: A
authors.lastname: Leriche
authors.forename: Philippe
authors.initials: P
authors.lastname: Paparel
authors.forename: Nicolas
authors.initials: N
authors.lastname: Morel-Journel
authors.forename: Alain
authors.initials: A
authors.lastname: Ruffion
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002492:Central Nervous System Depressants / Q000008:administration & dosage*; D000431:Ethanol / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008160:Lumbosacral Plexus; D008297:Male; D008875:Middle Aged; D009407:Nerve Block / Q000379:methods*; D012189:Retrospective Studies; D013126:Spinal Nerve Roots / Q000187:drug effects; D053201:Urinary Bladder, Overactive / Q000188:drug therapy*
chemical_list: D002492:Central Nervous System Depressants; D000431:Ethanol