Micro-reactors for PET tracer labeling.
Miniaturization of PET radiosynthesis devices (micro-reactors or microfluidic systems) is an emerging area that has the potential to deliver many advantages, such as more efficient use of hot-cell space for production of multiple radiotracers; use of less non-radioactive precursor for saving precious material and a reduced separation challenge; highly controlled, reproducible and reliable radiotracer production; and cheap, interchangeable, disposable and quality-assured radiochemistry processors. Several 'proof of principle' examples along with basics of micro-reactor flow control, mixing principle and design, and device fabrication are discussed in this chapter.
Lu
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PET Radiopharmaceutical Sciences, Molecular Imaging Branch, National Institute of Mental Health, NIH, Bethesda, MD 20892-1003, USA. ShuiyuLu@mail.nih.gov
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D000818:Animals; D002250:Carbon Radioisotopes / Q000737:chemistry; D004563:Electrochemistry; D005462:Fluorine Radioisotopes / Q000737:chemistry; D006801:Humans; D007700:Kinetics; D049268:Positron-Emission Tomography / Q000379:methods*; D014131:Trace Elements / Q000737:chemistry*
D002250:Carbon Radioisotopes; D005462:Fluorine Radioisotopes; D014131:Trace Elements