Vascular evaluation in laryngeal diseases: comparison between contact endoscopy and laser Doppler flowmetry.
OBJECTIVE
To determine the efficacies of 2 methods for evaluating vascular changes in laryngeal diseases.


METHODS
Prospective comparative study.


METHODS
University hospital.


METHODS
Twenty-four adults planning to undergo laryngomicrosurgery for unilateral lesions in their vocal cords.


METHODS
Vascular evaluation was performed using contact endoscopy and laser Doppler flowmetry during laryngomicrosurgery.


METHODS
Morphological and physiological variables of the vascular changes.


RESULTS
Contact endoscopy examinations revealed changes in the fine vascular network patterns in the vocal cords. Hypervascularity was present in patients with polyps but not in those with nodules, and the degree of vascularity was variable in patients with malignant neoplasms. Patients with papillomas and patients in the postradiation therapy group showed hypovascularity with losses in the capillary network. Laser Doppler flowmetry revealed high mean blood flows in patients with polyps, dysplasia, and malignant neoplasms, whereas patients with papillomas and those in the postradiation therapy group had low blood flows. The variables measured by laser Doppler flowmetry and endoscopy were strongly correlated.


CONCLUSIONS
Evaluations of morphological and physiological changes of vascularity in laryngeal diseases are important for understanding their pathophysiology, and combining contact endoscopy and laser Doppler flowmetry is useful in such evaluations.
Sone
Michihiko
M
Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, Japan. michsone@med.nagoya-u.ac.jp
Sato
Eisuke
E
Hayashi
Hideo
H
Fujimoto
Yasushi
Y
Nakashima
Tsutomu
T
D000328:Adult; D001783:Blood Flow Velocity / Q000502:physiology*; D018450:Disease Progression; D006801:Humans; D007818:Laryngeal Diseases / Q000473:pathology* / Q000503:physiopathology* / Q000601:surgery; D007828:Laryngoscopy / Q000379:methods*; D017078:Laser-Doppler Flowmetry / Q000379:methods*; D008866:Microsurgery / Q000379:methods; D011446:Prospective Studies; D015203:Reproducibility of Results; D014827:Vocal Cords / Q000098:blood supply*