title: [Epidermoid carcinoma larynx in stage IV].
abstract: OBJECTIVE
  To determine the survival, loco-regional control, distant metastases and second primary in stage IV laryngeal carcinoma treated by surgery and radiotherapy.
  
  
  METHODS
  Retrospective study of 147 patients treated with surgery and radiotherapy with a 5 year minimun follow-up.
  
  
  RESULTS
  Overall and cause specific survival at 5 and 10 years was 42%, 35% and 49%, 45.8% respectively. Loco-regional control was 57.7 % and 54.7% at 5 and 10 years. Local recurrences presented in 25.7%, regional recurrences in 74.2%, and distant metastases 10.9%. Second primary tumors developed in 12% of the patients, 50% of the cases in the lungs. Factors related to survival are evaluated.
  
  
  CONCLUSIONS
  In our experience, surgery with postoperative radiotherapy in N+, controls 45% of stage IV laryngeal carcinoma. Regional recurrencies are the main cause of failure, more frequent in N+ patientes, present in the first 36 months after treatment.
authors.affiliation: Servicio de Otorrinolaringología, Hospital Universitario Juan Canalejo, A Coruña. jhg@canalejo.org
authors.forename: J Herranz
authors.initials: JH
authors.lastname: González-Botas
authors.forename: J C
authors.initials: JC
authors.lastname: Vázquez Barro
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D012042:Registries