Fungal metabolites of (E)-guggulsterone and their antibacterial and radical-scavenging activities.
Fungal transformation of (E)-guggulsterone (= (17E)-pregna-4,17-diene-3,16-dione; 1) by Rhizopus stolonifer, Fusarium lini, Cunninghamella elegans, or Gibberella fujikuroi afforded ten hydroxylated metabolites (2-11; Scheme), which were fully characterized. Compounds 4-11 have not been described yet. Some of these novel hydroxylated metabolites, as well as acetylated derivatives thereof, exhibited significant antibacterial and radical-scavenging activities (Table 3).
Choudhary
M Iqbal
MI
H. E. J. Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi-75270, Pakistan. hej@cyber.net.pk
Shah
S Adnan Ali
SA
Sami
Amtul
A
Ajaz
Asma
A
Shaheen
Farzana
F
D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D016166:Free Radical Scavengers / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D005658:Fungi / Q000378:metabolism*; D015394:Molecular Structure; D011282:Pregnenediones / Q000737:chemistry* / Q000378:metabolism
D000900:Anti-Bacterial Agents; D016166:Free Radical Scavengers; D011282:Pregnenediones; C023617:pregna-4,17-diene-3,16-dione