[Molecular mechanisms in development of colorectal cancer metastasis].
The colorectal cancer can be mainly treated by surgery. Metastases are responsible for the poor prognosis. Development of metastases is a difficult, multi-level regulated process with complex molecular interactions. During the past decade, these mechanisms have become better known. Some parts of it had been clarified, others are still targets of the research. Analysis of this system can lead to find substances or methods, which could inhibit the development of metastases. Our aim was an exposition of the factors taking part in the process of development of colorectal metastases.
Bognár
Gábor
G
Sebészeti Klinika. bgabor@kut.sote.hu
Ledniczky
György
G
István
Gábor
G
Ondrejka
Pál
P
D000818:Animals; D017209:Apoptosis / Q000235:genetics; D002448:Cell Adhesion / Q000235:genetics; D015815:Cell Adhesion Molecules / Q000235:genetics / Q000378:metabolism*; D049109:Cell Proliferation; D015179:Colorectal Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology*; D005109:Extracellular Matrix / Q000378:metabolism; D006801:Humans; D009362:Neoplasm Metastasis / Q000235:genetics / Q000503:physiopathology*; D009360:Neoplastic Cells, Circulating / Q000378:metabolism; D009389:Neovascularization, Pathologic / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology*
D015815:Cell Adhesion Molecules