Performance of different ovarian reserve markers for predicting the numbers of oocytes retrieved and mature oocytes.
OBJECTIVE
To assess the performance of different ovarian reserve tests for predicting the total numbers of oocytes retrieved and mature oocytes.


METHODS
A retrospective study was performed on 71 women undergoing their first IVF/intracytoplasmic sperm injection treatment. Basal ovarian reserve screening was performed on days 2-3 of a spontaneous cycle. Patients were down-regulated with the GnRH agonist, whereas ovarian stimulation was carried out with recombinant FSH, starting from day 2 to 3 of the cycle. The main outcome measures were the numbers of oocytes retrieved and mature oocytes.


RESULTS
The total number of oocytes was positively correlated with AFC (p<0.0001) and E(2) levels post-GnRH (p<0.004), whereas there was an inverse correlation with age (p<0.0001). The number of mature oocytes also correlated with AFC (p<0.008) and E(2) levels post-GnRH (p<0.009), and inversely with age (p<0.0004). Univariate linear regression of square root of number of oocytes (SQNO) shows that acceptable predictors of number oocytes, based on model significance and R(2) are AFC (R(2)=0.215), age (R(2)=0.24) and E(2) variation (R(2)=0.09). The following model is proposed to predict the number of mature oocytes: ln(MO)=ln(NO)-2.09+0.028 AGE+0.03 BMI.


CONCLUSIONS
The number of antral follicles and patient age appear to be good markers of ovarian response in IVF treatments. Additional information is provided by stimulated E(2) levels.
Lorusso
Filomenamila
F
Department of General and Specialist Surgery, Gynaecology and Obstetric Unit A, University of Bari, Bari, Italy. milalorusso@yahoo.it
Vicino
Mario
M
Lamanna
Giuseppina
G
Trerotoli
Paolo
P
Serio
Gabriella
G
Depalo
Raffaella
R
D000328:Adult; D003661:Decision Support Techniques; D005260:Female; D005307:Fertilization in Vitro; D005640:Follicle Stimulating Hormone / Q000008:administration & dosage; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists; D006801:Humans; D009865:Oocytes / Q000502:physiology*; D006080:Ovarian Follicle / Q000502:physiology*; D010062:Ovulation Induction; D011247:Pregnancy; D012189:Retrospective Studies; D020554:Sperm Injections, Intracytoplasmic
D007987:Gonadotropin-Releasing Hormone; D005640:Follicle Stimulating Hormone