title: [A case of drug-induced pneumonitis due to amiodarone].
abstract: An 80-year-old man, who had been taking the antiarrhythmic drug amiodarone for chronic atrial fibrillation since October 2004, developed dyspnea and fever in June 2005, and was admitted to our hospital. Chest X-ray and CT scan showed ground-glass opacities in all lung fields. Arterial blood gas analysis revealed hypoxemia. These findings led to a diagnosis of acute respiratory distress syndrome. Oral amiodarone was discontinued, and steroid pulse therapy was started; however, the disease progressed rapidly, and the patient died on the fourth hospital day. Autopsy showed diffuse alveolar damage, accumulation of edema fluid in the alveolar spaces, and the presence of foamy macrophages, leading to a diagnosis of amiodarone-induced pulmonary damage.
authors.affiliation: Department of Respiratory Internal Medicine, Fujita Health University Second Educational Hospital.
authors.forename: Kashin
authors.initials: K
authors.lastname: Kobayashi
authors.forename: Takahiko
authors.initials: T
authors.lastname: Horiguchi
authors.forename: Rieko
authors.initials: R
authors.lastname: Kondo
authors.forename: Mamoru
authors.initials: M
authors.lastname: Shiga
authors.forename: Masahiro
authors.initials: M
authors.lastname: Hirose
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Itou
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Torigoe
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Hayashi
authors.forename: Daisuke
authors.initials: D
authors.lastname: Ouhira
mesh_terms: D000369:Aged, 80 and over; D000638:Amiodarone / Q000009:adverse effects*; D000889:Anti-Arrhythmia Agents / Q000009:adverse effects*; D001281:Atrial Fibrillation / Q000188:drug therapy; D002908:Chronic Disease; D006801:Humans; D008297:Male; D012128:Respiratory Distress Syndrome / Q000139:chemically induced* / Q000473:pathology
chemical_list: D000889:Anti-Arrhythmia Agents; D000638:Amiodarone