title: Terbinafine-induced hepatic failure requiring liver transplantation.
abstract: Drug-induced liver disease accounts for about 50% of acute or subacute liver failure in the United States. United Network of Organ Sharing (UNOS) data suggest 8%-20% of liver transplantation in this country per year is for fulminant liver failure due to drugs. Even though the most common medication implicated in acute liver injury is acetaminophen (75%), there are numerous other drugs that are responsible for acute and chronic liver injury. A variety of antifungal medications are known to cause a wide range of liver injury from a mild hepatocellular-cholestatic injury pattern to acute/subacute liver failure. Terbinafine is one of the antifungals that have been associated with such liver injuries. We report a case of terbinafine-induced severe liver failure requiring liver transplantation.
authors.affiliation: Piedmont Transplant Services, Piedmont Hospital, Atlanta, GA 30342, USA.
authors.forename: Zeeshan
authors.initials: Z
authors.lastname: Perveze
authors.forename: Mark W
authors.initials: MW
authors.lastname: Johnson
authors.forename: Raymond A
authors.initials: RA
authors.lastname: Rubin
authors.forename: Marty
authors.initials: M
authors.lastname: Sellers
authors.forename: Carlos
authors.initials: C
authors.lastname: Zayas
authors.forename: Jody L
authors.initials: JL
authors.lastname: Jones
authors.forename: Rosemary
authors.initials: R
authors.lastname: Cross
authors.forename: Kimberly
authors.initials: K
authors.lastname: Thomas
authors.forename: Bradley
authors.initials: B
authors.lastname: Butler
authors.forename: Roshan
authors.initials: R
authors.lastname: Shrestha
mesh_terms: D000082:Acetaminophen / Q000494:pharmacology; D000935:Antifungal Agents / Q000009:adverse effects*; D001652:Bile Ducts / Q000473:pathology; D002779:Cholestasis / Q000209:etiology; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000473:pathology; D017114:Liver Failure, Acute / Q000139:chemically induced*; D016031:Liver Transplantation / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009281:Naphthalenes / Q000009:adverse effects*; D000077291:Terbinafine
chemical_list: D000935:Antifungal Agents; D009281:Naphthalenes; D000082:Acetaminophen; D000077291:Terbinafine