Film/tablet adhesion, film thickness, internal stresses and bridging of the intagliations--a unified model with practical implications.
Building on previous work carried out over the past two decades, a unified and integrated model relating film/tablet adhesion, film thickness, internal stresses and the defect bridging of the intagliations has been developed. The model can explain the apparently anomalous results seen when measuring the adhesion of film coatings to tablet substrates as well as providing an insight into possible ways of preventing or minimising the incidence of bridging.
Rowe
Raymond C
RC
Institute of Pharmaceutical Innovation, University of Bradford, Bradford BD7 1DP, UK. r.c.rowe@bradford.ac.uk
D000268:Adhesiveness; D000465:Algorithms; D055598:Chemical Phenomena; D002626:Chemistry, Pharmaceutical / Q000706:statistics & numerical data*; D002627:Chemistry, Physical; D008956:Models, Chemical; D012997:Solvents; D013499:Surface Properties; D013607:Tablets / Q000737:chemistry*; D013608:Tablets, Enteric-Coated
D012997:Solvents; D013607:Tablets; D013608:Tablets, Enteric-Coated