Inhibitory effects of peony root extract on the large conductance calcium-activated potassium current essential in production of bursting activity.
To elucidate the mechanism of inhibitory action of peony root extract on pentylenetetrazol-induced bursting activity, effects of peony root extract on the iberiotoxin-sensitive large conductance calcium-activated potassium (BKCa) current that plays an essential role in the production of bursting activity were investigated. Peony root extract showed a clear inhibitory effect on the iberiotoxin-sensitive calcium-activated potassium current. Peony root extract also showed clear inhibitory effects on spontaneous bursting activity and BKCa current in the cerebral cortical neurons of the EL mouse, a hereditary epilepsy animal model. These results together with our previous studies, including the protective effect against neuron damage, indicate that peony root extract is a promising herbal drug for inhibition of convulsions.
Sugaya
Eiichi
E
Aieido clinic for Kampo (Japanese Herbal) Medicine, Musashino-shi, Tokyo, Japan. sugaya-ea@u01.gate01.com
Jin
Wen
W
Sugaya
Aiko
A
Sunaga
Katsuyoshi
K
Tsuda
Tadashi
T
D000200:Action Potentials / Q000187:drug effects*; D000818:Animals; D000927:Anticonvulsants / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D002478:Cells, Cultured; D002540:Cerebral Cortex / Q000166:cytology / Q000196:embryology; D051379:Mice; D008815:Mice, Inbred Strains; D029596:Paeonia; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018517:Plant Roots; D024681:Potassium Channels, Calcium-Activated / Q000187:drug effects*; D012640:Seizures / Q000188:drug therapy
D000927:Anticonvulsants; D010936:Plant Extracts; D024681:Potassium Channels, Calcium-Activated