title: The total synthesis of (+/-)-11-O-debenzoyltashironin.
abstract: The total synthesis of the putative non-peptidyl neurotrophic factor 11-O-debenzoyltashironin has been accomplished. The key transformation involves a biomimetic oxidative dearomatization/transannular Diels-Alder sequence that closes the tetracyclic carbon skeleton present in the natural product.
authors.affiliation: Department of Chemistry, Columbia University, Havemeyer Hall, 3000 Broadway, New York, NY 10027, USA.
authors.forename: Silas P
authors.initials: SP
authors.lastname: Cook
authors.forename: Alessandra
authors.initials: A
authors.lastname: Polara
authors.forename: Samuel J
authors.initials: SJ
authors.lastname: Danishefsky
mesh_terms: D001952:Bridged-Ring Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D029523:Illicium / Q000737:chemistry*; D015394:Molecular Structure; D010084:Oxidation-Reduction; D013237:Stereoisomerism
chemical_list: C516856:11-O-debenzoyltashironin; D001952:Bridged-Ring Compounds