title: Reversible binding of heme to proteins in cellular signal transduction.
abstract: Heme plays critical roles in numerous biological phenomena. Recent evidence has uncovered a new role of heme in cellular signal transduction, and its mechanism involves reversible binding of heme to proteins. This Account highlights the novel function of heme as an intracellular messenger in the regulation of gene expression and ion channel function.
authors.affiliation: Department of Physiology, University of Pennsylvania, Philadelphia, PA 19104, USA.
authors.forename: Shangwei
authors.initials: S
authors.lastname: Hou
authors.forename: Mark F
authors.initials: MF
authors.lastname: Reynolds
authors.forename: Frank T
authors.initials: FT
authors.lastname: Horrigan
authors.forename: Stefan H
authors.initials: SH
authors.lastname: Heinemann
authors.forename: Toshinori
authors.initials: T
authors.lastname: Hoshi
mesh_terms: D000818:Animals; D005786:Gene Expression Regulation; D006418:Heme / Q000096:biosynthesis / Q000737:chemistry / Q000378:metabolism*; D006420:Hemeproteins / Q000737:chemistry / Q000378:metabolism; D007473:Ion Channels / Q000378:metabolism; D011485:Protein Binding; D015398:Signal Transduction
chemical_list: D006420:Hemeproteins; D007473:Ion Channels; D006418:Heme