[Time course changes in cytokines content and gas composition in blood of patients with salmonellosis and acute shigellosis].
OBJECTIVE
To study changes in serum concentrations of interleukines (IL) and tumor necrosis factor alpha (TNFa) in the course of acute moderate and severe shigellosis and salmonellosis; to elicit their correlation with disorders of gas and electrolyte blood composition and acid-base balance (ABB).


METHODS
A total of 39 patients with salmonellosis and 32 patients with acute shigellosis admitted to infectious hospital N 2 entered the study. The following parameters were assessed: serum concentrations of IL-1, IL-IO and TNFa; ABB, gas and electrolyte blood composition; leucocytic intoxication index (LII). The tests were made on the disease day 2-3 and 6-7 (in severe salmonellosis on day 10-11).


RESULTS
In moderate salmonellesis and acute shigellosis the level of proinflammatory cytokines (IL-1 and TNFa) diminished while in severe acute intestinal infection their concentration was high reflecting imbalance of immune response. Content of IL-10 depends on etiology and severity of the course of infectious process - the highest IL-10 concentrations were found in patients with severe salmonellosis on the disease day 10-11. A direct correlation was confirmed between IL-1, TNFa and LII in the disease onset in all patients with acute intestinal infections.


CONCLUSIONS
An important role of IL-1, IL-10 and TNFa in pathogenesis of bacterial intestinal infections is confirmed. A correlation exists between blood gas composition and concentration of cytokines.
Martynova
N N
NN
Erovichenkov
A A
AA
Allenov
M N
MN
Pak
S G
SG
Umbetova
K t
Kt
D000136:Acid-Base Equilibrium; D000293:Adolescent; D000328:Adult; D001784:Blood Gas Analysis; D016207:Cytokines / Q000097:blood*; D004405:Dysentery, Bacillary / Q000276:immunology*; D005260:Female; D006801:Humans; D007375:Interleukin-1 / Q000097:blood; D016753:Interleukin-10 / Q000097:blood; D008297:Male; D008875:Middle Aged; D012480:Salmonella Infections / Q000276:immunology*; D012477:Salmonella enteritidis; D012763:Shigella flexneri; D013997:Time Factors; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D014882:Water-Electrolyte Balance
D016207:Cytokines; D007375:Interleukin-1; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10