title: PREDNOD, a prediction server for peptide binding to the H-2g7 haplotype of the non-obese diabetic mouse.
abstract: The non-obese diabetic (NOD) mouse is a widely used animal model for study of autoimmune diseases, in particular human type 1 diabetes mellitus (T1DM). Identification of the subset of peptides that bind MHC molecules comprising the H-2g7 haplotype of NOD mouse and thereby representing potential NOD T-cell epitopes is important for research into the pathogenesis and immunotherapy of T1DM. The H-2g7 haplotype comprises the MHC class-I molecules Kd and Db and a single class-II molecule I-Ag7. We have developed a prediction system, PREDNOD, for accurate identification of peptides that bind the MHC molecules constituting the H-2g7 haplotype. PREDNOD is accessible at http://antigen.i2r.a-star.edu.sg/Ag7.
authors.affiliation: Institute for Infocomm Research, 21 Heng Mui Keng Terrace, Singapore, Singapore, 119613.
authors.forename: Menaka
authors.initials: M
authors.lastname: Rajapakse
authors.forename: Guang Lan
authors.initials: GL
authors.lastname: Zhang
authors.forename: Kellathur N
authors.initials: KN
authors.lastname: Srinivasan
authors.forename: Bertil
authors.initials: B
authors.lastname: Schmidt
authors.forename: Nikolai
authors.initials: N
authors.lastname: Petrovsky
authors.forename: Vladimir
authors.initials: V
authors.lastname: Brusic
mesh_terms: D000465:Algorithms; D000595:Amino Acid Sequence; D000818:Animals; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology / Q000378:metabolism*; D018984:Epitopes, T-Lymphocyte / Q000276:immunology; D006183:H-2 Antigens / Q000276:immunology / Q000378:metabolism*; D006239:Haplotypes; D051379:Mice; D016688:Mice, Inbred NOD / Q000276:immunology / Q000378:metabolism*; D018448:Models, Immunological; D008969:Molecular Sequence Data; D010455:Peptides; D011237:Predictive Value of Tests; D011485:Protein Binding; D012984:Software
chemical_list: D018984:Epitopes, T-Lymphocyte; D006183:H-2 Antigens; D010455:Peptides