Irradiation-induced uterine malignant mixed müllerian tumor.
OBJECTIVE
To report a case of a patient with cervical squamous cell carcinoma stage IIIB who was diagnosed with malignant mixed müllerian tumor (MMMT) 5 years after radiotherapy.


METHODS
A 57-year-old female patient with cervical squamous cell carcinoma FIGO stage IIIB received pelvic irradiation for her disease. After radiotherapy, she was followed-up every 6 months. At 60 months, Papanicolaou smear revealed abnormal cancer cells and secondary MMMT was diagnosed. The patient underwent surgical treatment followed by chemotherapy. However, the cancer recurred 8 months after surgery and the patient died 1 month later.


CONCLUSIONS
Patients with cervical cancer administered irradiation many years previously remain at high risk of secondary malignancies. In these cases, long-term follow-up with extreme caution is mandatory. For patients with any types of symptoms, aggressive and immediate investigation is suggested in order to detect possible occult malignancies.
Huang
Ying-Ti
YT
Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital, Linkou Medical Center and Chang Gung University College of Medicine, Kwei-Shan, Tao-Yuan, Taiwan.
Huang
Kuan-Gen
KG
Ueng
Shir-Hwa
SH
Shaw
Sheng-Wen
SW
D000230:Adenocarcinoma / Q000175:diagnosis / Q000209:etiology*; D002294:Carcinoma, Squamous Cell / Q000532:radiotherapy*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008875:Middle Aged; D018200:Mixed Tumor, Mullerian / Q000175:diagnosis / Q000209:etiology*; D009364:Neoplasm Recurrence, Local; D009381:Neoplasms, Radiation-Induced / Q000175:diagnosis*; D011878:Radiotherapy / Q000009:adverse effects; D002583:Uterine Cervical Neoplasms / Q000532:radiotherapy*