title: Talosins A and B: new isoflavonol glycosides with potent antifungal activity from Kitasatospora kifunensis MJM341. II. Physicochemical properties and structure determination.
abstract: In our screening program for new antifungal agents from microbial secondary metabolites, two new isoflavonol glycosides, with potent antifungal activity, talosins A and B, were isolated from the culture broth of Kitasatospora kifunensis MJM341. Talosins A and B were determined to be genistein 7-alpha-L-6-deoxy-talopyranoside and genistein 4',7-di-alpha-L-6-deoxy-talopyranoside, respectively, by spectroscopic studies. They are the first flavonoid glycosides incorporating 6-deoxy-talose as a sugar component.
authors.affiliation: Korea Research Institute of Bioscience and Biotechnology, P.O. Box 115, Yuseong-Gu, Daejeon, 305-600, Korea.
authors.forename: Won-Gon
authors.initials: WG
authors.lastname: Kim
authors.forename: Tae Mi
authors.initials: TM
authors.lastname: Yoon
authors.forename: Hyung Jin
authors.initials: HJ
authors.lastname: Kwon
authors.forename: Joo Won
authors.initials: JW
authors.lastname: Suh
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry*; D006027:Glycosides / Q000737:chemistry*; D007529:Isoflavones / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D013306:Streptomycetaceae / Q000737:chemistry*
chemical_list: D000935:Antifungal Agents; D006027:Glycosides; D007529:Isoflavones; C516692:genistein 4',7'-bis(6-deoxytalopyranoside); C516691:genistein 7-(6-deoxytalopyranoside)