title: Apoptosis-associated gene expression in HIV-infected patients in response to successful antiretroviral therapy.
abstract: The simultaneous expression of 19 apoptosis-related genes was analyzed by RNA-protection assay in peripheral blood mononuclear cells of HIV-infected patients before and during successful antiretroviral therapy (ART). After 12 months of therapy, the expression of the pro-apoptotic genes FAS, FAS-L, FAF-1, FADD, CASPASE-8, DR3, TRAIL, TNFR-1, TRADD, and BAX was significantly downregulated with respect to time 0, while that of BCL-2, BCL-XL, and MCL-1 was significantly upregulated. The data suggest that inhibition of cell death in HIV-positive patients under successful therapy is the result of a complex network of multifactor signaling, correlated with both death and survival of lymphocytes.
authors.affiliation: Department of Neuroscience, University of Rome Tor Vergata, Rome, Italy.
authors.forename: Emanuela
authors.initials: E
authors.lastname: Balestrieri
authors.forename: Sandro
authors.initials: S
authors.lastname: Grelli
authors.forename: Claudia
authors.initials: C
authors.lastname: Matteucci
authors.forename: Antonella
authors.initials: A
authors.lastname: Minutolo
authors.forename: Gabriella
authors.initials: G
authors.lastname: d'Ettorre
authors.forename: Fiorella
authors.initials: F
authors.lastname: Di Sora
authors.forename: Francesco
authors.initials: F
authors.lastname: Montella
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Vullo
authors.forename: Stefano
authors.initials: S
authors.lastname: Vella
authors.forename: Cartesio
authors.initials: C
authors.lastname: Favalli
authors.forename: Beatrice
authors.initials: B
authors.lastname: Macchi
authors.forename: Antonio
authors.initials: A
authors.lastname: Mastino
mesh_terms: D019380:Anti-HIV Agents / Q000627:therapeutic use; D017209:Apoptosis; D004359:Drug Therapy, Combination; D005786:Gene Expression Regulation; D015658:HIV Infections / Q000188:drug therapy* / Q000235:genetics / Q000276:immunology / Q000821:virology; D015497:HIV-1; D006801:Humans; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology / Q000378:metabolism* / Q000502:physiology; D011506:Proteins / Q000235:genetics / Q000378:metabolism; D018894:Reverse Transcriptase Inhibitors / Q000627:therapeutic use; D012260:Ribonucleases / Q000378:metabolism; D016896:Treatment Outcome
chemical_list: D019380:Anti-HIV Agents; D011506:Proteins; D018894:Reverse Transcriptase Inhibitors; D012260:Ribonucleases