Trichotomoside: a new antioxidative phenylpropanoid glycoside from Clerodendron trichotomum.
The structure and antioxidant properties of a new natural glycoside, trichotomoside (1), isolated from Clerodendron trichotomum, were investigated. Trichotomoside was identified as 2-(3-hydroxy-4-methoxyphenyl)ethyl 3-O-(2,3-di-O-acetyl-alpha-L-rhamnopyranosyl)-4-O-[(2E)-3-(3-hydroxy-4-methoxyphenyl)prop-2-enoyl]-beta-D-glucopyranoside. The compound was active towards intracellular reactive oxygen species (ROS) and exhibited DPPH-radical-scavenging effects. The radical-scavenging activity of 1 was found to protect the viability of Chinese hamster lung fibroblasts (V79-4 cells) exposed to H2O2 and gamma-irradiation.
Chae
Sungwook
S
Natural Products Research Institute and College of Pharmacy, Seoul National University, Seoul 110-460, Korea.
Kang
Kyoung Ah
KA
Kim
Ju Sun
JS
Hyun
Jin Won
JW
Kang
Sam Sik
SS
D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects / Q000502:physiology; D032409:Clerodendrum; D006224:Cricetinae; D003412:Cricetulus; D004305:Dose-Response Relationship, Drug; D016166:Free Radical Scavengers / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018547:Plant Stems; D020005:Propanols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D000975:Antioxidants; D016166:Free Radical Scavengers; D006027:Glycosides; D010936:Plant Extracts; D020005:Propanols; C439395:1-phenylpropanol