A two phase harmonic model for left ventricular function.
A minimal model for mechanical motion of the left ventricle is proposed. The model assumes the left ventricle to be a harmonic oscillator with two distinct phases, simulating the systolic and diastolic phases, at which both the amplitude and the elastic constant of the oscillator are different. Taking into account the pressure within the left ventricle, the model shows qualitative agreement with functional parameters of the left ventricle. The model allows for a natural explanation of heart failure with preserved systolic left ventricular function, also termed diastolic heart failure. Specifically, the rise in left ventricular filling pressures following increased left-ventricular wall stiffness is attributed to a mechanism aimed at preserving heart rate and cardiac output.
Dubi
Shay
S
Sackler Faculty of Medicine, Tel Aviv University, Israel.
Dubi
Chen
C
Dubi
Yonatan
Y
D001683:Biological Clocks; D054144:Heart Failure, Diastolic / Q000503:physiopathology; D008954:Models, Biological; D009200:Myocardial Contraction / Q000502:physiology*; D016277:Ventricular Function, Left / Q000502:physiology*; D017725:Ventricular Pressure