title: Lipid peroxidation is enhanced in Yusho victims 35 years after accidental poisoning with polychlorinated biphenyls in Nagasaki, Japan.
abstract: Thirty-five years have passed since the accidental poisoning with polychlorinated biphenyls (PCB) in Japan and yet high concentrations of PCB are still detected in the serum of the victims. PCB produces superoxide and thus victims are considered to be in a persistent state of oxidative stress. Urinary concentrations of 8-isoprostane (8IP) in the victims and age-matched controls were measured to assess this hypothesis. The mean urinary concentration of 8IP was significantly higher than that in the controls. There was a positive correlation between urinary 8IP and serum concentrations of cholinesterase. It was considered that Yusho is an oxidative stress and 8IP is a useful tool for checking the oxidative condition in Yusho victims.
authors.affiliation: Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan. kasimizu@net.nagasaki-u.ac.jp
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Shimizu
authors.forename: Fumihide
authors.initials: F
authors.lastname: Ogawa
authors.forename: Jens J
authors.initials: JJ
authors.lastname: Thiele
authors.forename: Sangjae
authors.initials: S
authors.lastname: Bae
authors.forename: Shinichi
authors.initials: S
authors.lastname: Sato
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000652:urine; D015237:Dinoprost / Q000031:analogs & derivatives / Q000652:urine; D018876:Environmental Illness / Q000209:etiology / Q000378:metabolism*; D004785:Environmental Pollutants / Q000506:poisoning*; D005506:Food Contamination; D005517:Foodborne Diseases / Q000209:etiology / Q000378:metabolism*; D006801:Humans; D007564:Japan; D015227:Lipid Peroxidation / Q000187:drug effects*; D018384:Oxidative Stress / Q000187:drug effects*; D011078:Polychlorinated Biphenyls / Q000097:blood / Q000506:poisoning*
chemical_list: D015415:Biomarkers; D004785:Environmental Pollutants; C075750:8-epi-prostaglandin F2alpha; D015237:Dinoprost; D011078:Polychlorinated Biphenyls