[Peripheral T-cell lymphoma presenting with eosinophilia due to interleukin-5 produced by lymphoma cells].
A 72-year-old male was admitted to our hospital to determine the cause of neck lymphadenopathies. He was diagnosed pathologically by a lymph node biopsy as having peripheral T-cell lymphoma (PTCL). He also had developed eosinophilia and his serum concentration of Interleukin-5 (IL-5) was extremely high. Immunostaining of a resected lymph node revealed that there were lymphoma cells which were stained with anti-IL-5 antibody. After 2 courses of CHOP therapy, the lymphadenopathies and eosinophilia disappeared and the concentration of serum IL-5 was normalized. It was suggested that IL-5 produced by lymphoma cells had induced his eosinophilia.
Matsunaga
Takuya
T
Fourth Department of Internal Medicine, Sapporo Medical University, School of Medicine.
Sato
Tsutomu
T
Iyama
Satoshi
S
Tanaka
Shingo
S
Murase
Kazuyuki
K
Sato
Yasushi
Y
Kobune
Masayoshi
M
Takimoto
Rishu
R
Kato
Junji
J
Kuroda
Hiroyuki
H
Niitsu
Yoshiro
Y
D000368:Aged; D004802:Eosinophilia / Q000209:etiology*; D006801:Humans; D015848:Interleukin-5 / Q000096:biosynthesis*; D016411:Lymphoma, T-Cell, Peripheral / Q000150:complications / Q000378:metabolism*; D008297:Male
D015848:Interleukin-5