title: Successful treatment of myelodysplastic syndrome-induced pyoderma gangrenosum.
abstract: We report successful treatment of a refractory myelodysplastic syndrome-associated pyoderma gangrenosum with the combination of thalidomide and interferon-alpha2a in a single patient. A non-healing wound developed on a 40-year-old woman's left thumb after minor trauma. Massive ulcerovegetative lesions developed after reconstruction surgery. Histopathological examination of the bone marrow and cytogenetic studies revealed an atypical myeloproliferative/myelodysplastic syndrome. The skin lesions resolved dramatically after two months of thalidomide and interferon-alpha2a combination therapy and the haematological status improved.
authors.affiliation: Department of Internal Medicine, Division of Haematology, Hacettepe University Medical School, Turkey. ekoca@hacettepe.edu.tr
authors.forename: E
authors.initials: E
authors.lastname: Koca
authors.forename: A E
authors.initials: AE
authors.lastname: Duman
authors.forename: D
authors.initials: D
authors.lastname: Cetiner
authors.forename: Y
authors.initials: Y
authors.lastname: Buyukasik
authors.forename: I C
authors.initials: IC
authors.lastname: Haznedaroglu
authors.forename: A
authors.initials: A
authors.lastname: Uner
authors.forename: B
authors.initials: B
authors.lastname: Demirhan
authors.forename: U
authors.initials: U
authors.lastname: Kerimoglu
authors.forename: I
authors.initials: I
authors.lastname: Barista
authors.forename: M
authors.initials: M
authors.lastname: Calguneri
authors.forename: O I
authors.initials: OI
authors.lastname: Ozcebe
mesh_terms: D000328:Adult; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000008:administration & dosage*; D009190:Myelodysplastic Syndromes / Q000150:complications* / Q000188:drug therapy; D017511:Pyoderma Gangrenosum / Q000188:drug therapy* / Q000209:etiology*; D011994:Recombinant Proteins; D013792:Thalidomide / Q000008:administration & dosage*; D016896:Treatment Outcome
chemical_list: D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; D013792:Thalidomide