Oxachelin, a novel iron chelator and antifungal agent from Streptomyces sp. GW9/1258.
During a screening campaign for new antimicrobial and antifungal secondary metabolites from several thousand actinomycetes, a novel compound, isolated by activity guided fractionation, was oxachelin (1) from the new Streptomyces sp. GW9/1258. Oxachelin shows strong antibiotic activities against several fungi and Gram(+) bacteria. Additionally, oxachelin is a strong complexing ligand for Fe3+ (siderophore), possibly making it useful e.g. for iron excess diseases.
Sontag
Bernd
B
BioFocus DPI GmbH, Waldhofer Str. 104, D-69123 Heidelberg, Germany. bernd.sontag@glpg.com
Gerlitz
Martin
M
Paululat
Thomas
T
Rasser
Hans-Falk
HF
Grün-Wollny
Iris
I
Hansske
Friedrich G
FG
D000935:Antifungal Agents / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D005658:Fungi / Q000187:drug effects; D007502:Iron Chelating Agents / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D009842:Oligopeptides / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D010080:Oxazoles / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects; D013302:Streptomyces / Q000145:classification* / Q000378:metabolism*
D000935:Antifungal Agents; D007502:Iron Chelating Agents; D009842:Oligopeptides; D010080:Oxazoles; C516693:oxachelin