title: The protein encoded by the gene proliferation disrupter (prod) is associated with the telomeric retrotransposon array in Drosophila melanogaster.
abstract: We report in this paper that the PROD protein, encoded by the gene proliferation disrupter (prod), is associated with the telomeric chromatin in Drosophila melanogaster. It binds to a region just upstream of the promoter of the telomere-specific retrotransposon HeT-A, which is located in the long 3'untranslated region of the element near its oligo(A) tail. Reduction of PROD in prod heterozygote flies results in elevated levels of HeT-A RNA in the ovaries, suggesting that PROD functions as a repressor of HeT-A transcriptional activity at the telomeres.
authors.affiliation: Department of Genetics and Molecular Biology, University of Szeged, Szeged, Hungary.
authors.forename: Tibor
authors.initials: T
authors.lastname: Török
authors.forename: Cecil
authors.initials: C
authors.lastname: Benitez
authors.forename: Sándor
authors.initials: S
authors.lastname: Takács
authors.forename: Harald
authors.initials: H
authors.lastname: Biessmann
mesh_terms: D000818:Animals; D002843:Chromatin / Q000235:genetics / Q000378:metabolism*; D002868:Chromosomal Proteins, Non-Histone / Q000235:genetics* / Q000378:metabolism; D002871:Chromosome Banding; D017931:DNA Primers; D029721:Drosophila Proteins / Q000235:genetics* / Q000378:metabolism; D004331:Drosophila melanogaster / Q000235:genetics*; D005260:Female; D005786:Gene Expression Regulation / Q000235:genetics*; D015683:Gene Products, gag / Q000235:genetics / Q000378:metabolism; D008957:Models, Genetic; D010053:Ovary / Q000378:metabolism; D011485:Protein Binding; D012097:Repressor Proteins / Q000235:genetics* / Q000378:metabolism; D018626:Retroelements / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction; D016615:Telomere / Q000235:genetics / Q000378:metabolism*
chemical_list: D002843:Chromatin; D002868:Chromosomal Proteins, Non-Histone; D017931:DNA Primers; D029721:Drosophila Proteins; D015683:Gene Products, gag; C103996:HeT-A-gag protein, Drosophila; D012097:Repressor Proteins; D018626:Retroelements; C103826:prod protein, Drosophila