Associations between connexin37 gene polymorphism and markers of subclinical atherosclerosis: the Cardiovascular Risk in Young Finns study.
OBJECTIVE
Connexin37 (cx37) C1019T polymorphism has been shown to associate with coronary artery disease in different populations. We investigated whether this polymorphism associates with carotid artery intima-media thickness (IMT), carotid artery compliance (CAC) and brachial artery flow mediated dilatation (FMD) - i.e., early ultrasound markers of subclinical atherosclerosis - in a clinically healthy population of young Finnish adults.


RESULTS
1440 individuals from the Cardiovascular Risk in Young Finns study were genotyped and studied using cardiovascular risk factor and ultrasound data obtained in 2001. In linear regression models, no significant association between the cx37 polymorphism and carotid IMT, CAC or brachial artery FMD (ANOVA, p=0.159, 0.151 and 0.547), respectively, was found in the whole population or in women and men separately.


CONCLUSIONS
The connexin37 C1019T polymorphism is not related with markers of subclinical atherosclerosis in young adults.
Collings
Auni
A
Laboratory of Atherosclerosis Genetics, Centre for Laboratory Medicine, Tampere University Hospital, Tampere University Medical School, Finland. Auni.Collings@psghp.fi
Islam
Md Shaheenul
MS
Juonala
Markus
M
Rontu
Riikka
R
Kähönen
Mika
M
Hutri-Kähönen
Nina
N
Laitinen
Tomi
T
Marniemi
Jukka
J
Viikari
Jorma S A
JS
Raitakari
Olli T
OT
Lehtimäki
Terho J
TJ
D000328:Adult; D000367:Age Factors; D001916:Brachial Artery / Q000502:physiology; D002340:Carotid Artery Diseases / Q000000981:diagnostic imaging / Q000235:genetics*; D015331:Cohort Studies; D017630:Connexins / Q000235:genetics*; D005260:Female; D005387:Finland; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D017539:Tunica Intima / Q000000981:diagnostic imaging; D017540:Tunica Media / Q000000981:diagnostic imaging; D014463:Ultrasonography; D014664:Vasodilation / Q000235:genetics* / Q000502:physiology; D000097006:Gap Junction alpha-4 Protein
D017630:Connexins; D000097006:Gap Junction alpha-4 Protein