Delivery mode and efficacy of BMP-2 in association with implants.
Bone healing may be improved in implant patients by the administration of osteogenic agents, such as bone morphogenetic protein 2 (BMP-2). But the efficacy of BMP-2 depends upon its mode of application. We hypothesized that BMP-2 is capable of a higher osteogenic efficacy when delivered physiologically, viz., when incorporated into a calcium-phosphate carrier that mimics mineralized bone matrix, than when administered via simple pharmacological modes, such as by adsorption onto a carrier surface. Using an ectopic rat model, we compared the osteoinductive efficacies of calcium-phosphate implant-coatings bearing either incorporated, adsorbed, or incorporated and adsorbed BMP-2. When adsorbed directly onto the naked implant surface, BMP-2 was not osteogenic. When adsorbed onto a calcium-phosphate coating, it was osteoinductive, but not highly efficacious. When BMP-2 was incorporated into calcium-phosphate coatings, it was a potent bone-inducer, whose efficacy was compromised, not potentiated, by the additional deposition of an adsorbed pool.
Liu
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ITI Research Institute for Dental and Skeletal Biology, University of Bern, Switzerland.
Huse
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de Groot
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Buser
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Hunziker
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EB
D000327:Adsorption; D000497:Alloys / Q000737:chemistry; D000818:Animals; D040761:Biomimetic Materials / Q000737:chemistry; D055396:Bone Morphogenetic Protein 2; D019485:Bone Morphogenetic Proteins / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology; D002130:Calcium Phosphates / Q000737:chemistry; D020099:Coated Materials, Biocompatible / Q000737:chemistry; D062109:Dermatologic Surgical Procedures; D020007:Implants, Experimental; D008297:Male; D023421:Models, Animal; D009999:Ossification, Heterotopic / Q000139:chemically induced; D010012:Osteogenesis / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D014025:Titanium / Q000737:chemistry; D016212:Transforming Growth Factor beta / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology
D000497:Alloys; C525720:Bmp2 protein, rat; D055396:Bone Morphogenetic Protein 2; D019485:Bone Morphogenetic Proteins; D002130:Calcium Phosphates; D020099:Coated Materials, Biocompatible; D016212:Transforming Growth Factor beta; C031462:titanium alloy (TiAl6V4); C020243:calcium phosphate; D014025:Titanium