title: Solid-phase synthesis and CD spectroscopic investigations of novel beta-peptides from L-aspartic acid and beta-amino-L-alanine.
abstract: [structure: see text] A solid-phase synthesis method for the preparation of novel beta3- and beta2-peptides derived from l-aspartic acid and beta-amino-l-alanine, respectively, is described. The methodology allows independent buildup of the beta-peptide backbone and the introduction of sequential side chain substitutions. Representative peptides from the two classes, an amino-substituted beta3-hexapeptide and an acyl-substituted beta2-hexapeptide, have been prepared, and their solution conformation is studied by circular dichroism (CD) spectroscopy.
authors.affiliation: Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada.
authors.forename: Sahar
authors.initials: S
authors.lastname: Ahmed
authors.forename: Reem
authors.initials: R
authors.lastname: Beleid
authors.forename: Tara
authors.initials: T
authors.lastname: Sprules
authors.forename: Kamaljit
authors.initials: K
authors.lastname: Kaur
mesh_terms: D000586:Amination; D001224:Aspartic Acid / Q000737:chemistry*; D002942:Circular Dichroism; D015394:Molecular Structure; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry; D011422:Propionates / Q000737:chemistry; D015091:beta-Alanine / Q000737:chemistry*
chemical_list: D010455:Peptides; D011422:Propionates; D015091:beta-Alanine; D001224:Aspartic Acid; C029658:propionic acid