title: Characterization of the epidemic influenza B viruses isolated during 2004-2005 season in Taiwan.
abstract: To characterize the antigenic and genetic relationships of influenza B viruses isolated during the 2004-2005 season, a total of 11,707 clinical respiratory samples were tested of which 1572 (13.5%) were positive for influenza (463 type A and 1109 type B influenza). Of the type B viruses, 348 isolates collected in different parts of Taiwan were further analyzed. Viruses belonging to both influenza B lineages, B/Yamagata/16/88 (B/Yam) and B/Victoris/2/87 (B/Vic) were detected, although an increasing number of B/Vic lineage isolates was obtained as the season progressed. Recent B/Vic-lineage isolates were found to have additional amino acid substitutions compared to isolates from previous seasons, indicating that viruses of this lineage continue to evolve significantly and may have the capacity to become the dominant influenza B viruses worldwide. Results presented in this report demonstrate that antigenically and genetically distinct viruses within both B/Vic and B/Yam lineages co-circulate and that reassortment among these two lineages occurs frequently contributing to the genetic diversity of the circulating strains.
authors.affiliation: Division of Research and Laboratory Diagnosis, Center for Disease Control, 161 Kun-Yang Street, Taipei, Taiwan, ROC. jeffy320@cdc.gov.tw
authors.forename: Jih-Hui
authors.initials: JH
authors.lastname: Lin
authors.forename: Shu-Chun
authors.initials: SC
authors.lastname: Chiu
authors.forename: Michael W
authors.initials: MW
authors.lastname: Shaw
authors.forename: Yung-Cheng
authors.initials: YC
authors.lastname: Lin
authors.forename: Cheng-Hao
authors.initials: CH
authors.lastname: Lee
authors.forename: Hour-Yung
authors.initials: HY
authors.lastname: Chen
authors.forename: Alexander
authors.initials: A
authors.lastname: Klimov
mesh_terms: D019943:Amino Acid Substitution / Q000235:genetics; D000956:Antigens, Viral / Q000032:analysis*; D001483:Base Sequence; D004196:Disease Outbreaks; D006801:Humans; D009981:Influenza B virus / Q000145:classification* / Q000235:genetics* / Q000276:immunology / Q000302:isolation & purification; D007251:Influenza, Human / Q000453:epidemiology* / Q000821:virology*; D008969:Molecular Sequence Data; D020125:Mutation, Missense / Q000235:genetics; D010802:Phylogeny; D012367:RNA, Viral / Q000235:genetics; D016865:Reassortant Viruses / Q000235:genetics; D017422:Sequence Analysis, DNA; D013624:Taiwan / Q000453:epidemiology
chemical_list: D000956:Antigens, Viral; D012367:RNA, Viral