The functions of RPS19 and their relationship to Diamond-Blackfan anemia: a review.
The relatively new study of ribosomal proteins has allowed for greater understanding of protein synthesis; however the connection between ribosomal proteins' roles and that of disease pathophysiology has not yet been established. RPS19 is a ribosomal protein linked to Diamond-Blackfan anemia whose functions have begun to be elucidated. We review here the known roles of RPS19 in both ribosome construction and other extra-ribosomal functions and discuss their relationship to Diamond-Blackfan anemia.
Morimoto
Kenji
K
Division of Hematology/Oncology, Department of Pediatrics, UCLA Mattel Children's Hospital, CA 90095, USA. kmorimoto@mednet.ucla.edu
Lin
Shou
S
Sakamoto
Kathleen
K
D029503:Anemia, Diamond-Blackfan / Q000235:genetics* / Q000378:metabolism; D020022:Genetic Predisposition to Disease; D006801:Humans; D012269:Ribosomal Proteins / Q000235:genetics* / Q000378:metabolism; D012270:Ribosomes / Q000235:genetics / Q000378:metabolism*
D012269:Ribosomal Proteins; C040343:ribosomal protein S19