Vitreous levels of interleukin-8 in patients with proliferative diabetic retinopathy.
OBJECTIVE
To determine the levels of interleukin 8 (IL-8) in the vitreous of patients with proliferative diabetic retinopathy (PDR).


METHODS
Observational case-control study.


METHODS
Vitreous fluid samples were obtained by vitreoretinal surgery from 71 eyes of patients with diabetes mellitus type 2 with PDR and from 17 eyes of nondiabetic patients with a macular hole. PDR was classified as active and inactive and subdivided according to the extent of large-vessel gliotic obliteration. The cytokine levels were measured by cytometric bead array method.


RESULTS
The vitreous levels of IL-8 were significantly higher in patients with PDR in comparison with the control subjects (P < .001) and in patients with higher extent of large vessel gliotic obliteration (P < .001). A vitreous level of IL-8 was not associated with the presence of active PDR.


CONCLUSIONS
Increased levels of IL-8 in PDR were associated with a higher extent of large-vessel gliotic obliteration.
Petrovic
Mojca Globocnik
MG
University Eye Clinic, Medical Centre Ljubljana, Zaloska 29a, 1000 Ljubljana, Slovenia. ngpetrovic@yahoo.com
Korosec
Peter
P
Kosnik
Mitja
M
Hawlina
Marko
M
D000368:Aged; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000378:metabolism; D003930:Diabetic Retinopathy / Q000209:etiology / Q000378:metabolism*; D005911:Gliosis / Q000378:metabolism; D006801:Humans; D016209:Interleukin-8 / Q000378:metabolism*; D008875:Middle Aged; D015861:Retinal Neovascularization / Q000209:etiology / Q000378:metabolism; D014822:Vitreous Body / Q000378:metabolism*
D016209:Interleukin-8