title: Interferon receptor expression in multiple sclerosis patients.
abstract: To determine the gene expression of IFNAR1, IFNAR2 and MxA protein and the association with IFNbeta treatment response in MS patients. MS patients treated with IFNbeta had a significant decrease in IFNAR1 and IFNAR2 expression, and a significant increase in MxA compared to non-treated patients and healthy controls. Also, those patients who had a good response to treatment had a significant decrease in IFNAR1 and IFNAR2 expression compared to non-responders, non-treated patients and healthy controls. IFNbeta influences the expression of its receptors, and is greater in patients who respond to IFNbeta treatment. This down-regulation could be indicative of the response to IFNbeta.
authors.affiliation: Research Laboratory, Carlos Haya Hospital, Málaga, Spain.
authors.forename: Begoña
authors.initials: B
authors.lastname: Oliver
authors.forename: Cristobalina
authors.initials: C
authors.lastname: Mayorga
authors.forename: Victoria
authors.initials: V
authors.lastname: Fernández
authors.forename: Laura
authors.initials: L
authors.lastname: Leyva
authors.forename: Antonio
authors.initials: A
authors.lastname: León
authors.forename: Gloria
authors.initials: G
authors.lastname: Luque
authors.forename: Juan C
authors.initials: JC
authors.lastname: López
authors.forename: Jose A
authors.initials: JA
authors.lastname: Tamayo
authors.forename: Maria J
authors.initials: MJ
authors.lastname: Pinto-Medel
authors.forename: Enrique
authors.initials: E
authors.lastname: de Ramon
authors.forename: Eva
authors.initials: E
authors.lastname: Blanco
authors.forename: Ana
authors.initials: A
authors.lastname: Alonso
authors.forename: Oscar
authors.initials: O
authors.lastname: Fernández
mesh_terms: D000328:Adult; D005260:Female; D005786:Gene Expression Regulation / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D016899:Interferon-beta / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000188:drug therapy / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism; D017471:Receptors, Interferon / Q000235:genetics / Q000378:metabolism*; D020133:Reverse Transcriptase Polymerase Chain Reaction / Q000379:methods
chemical_list: D012333:RNA, Messenger; D017471:Receptors, Interferon; D016899:Interferon-beta