Assessment of the effect of mefloquine on artesunate pharmacokinetics in healthy male volunteers.
The effect of mefloquine on artesunate pharmacokinetics was assessed in 20 volunteers given artesunate for 3 days, followed > or =21 days later by combination therapy for 3 days. The areas under the concentration-time curve from 0 h to infinity for dihydroartemisinin, the active metabolite of artesunate, were similar on day 3 of the two dosing periods (P = 0.12), implying no interaction.
Davis
Timothy M E
TM
School of Medicine and Pharmacology, University of Western Australia, Fremantle Hospital, P.O. Box 480, Fremantle, Western Australia 6959, Australia. tdavis@cyllene.uwa.edu.au
England
Michelle
M
Dunlop
Anne-Marie
AM
Page-Sharp
Madhu
M
Cambon
Nathalie
N
Keller
Thomas G
TG
Heidecker
János L
JL
Ilett
Kenneth F
KF
D000328:Adult; D000962:Antimalarials / Q000493:pharmacokinetics* / Q000494:pharmacology*; D019540:Area Under Curve; D037621:Artemisinins / Q000097:blood / Q000493:pharmacokinetics*; D000077332:Artesunate; D002851:Chromatography, High Pressure Liquid; D004347:Drug Interactions; D006801:Humans; D008297:Male; D015767:Mefloquine / Q000494:pharmacology*; D008875:Middle Aged; D012717:Sesquiterpenes / Q000097:blood / Q000493:pharmacokinetics*; D013056:Spectrophotometry, Ultraviolet
D000962:Antimalarials; D037621:Artemisinins; D012717:Sesquiterpenes; D000077332:Artesunate; C039060:artenimol; D015767:Mefloquine