Pretransplant soluble CD30 level has limited effect on acute rejection, but affects graft function in living donor kidney transplantation.
BACKGROUND
Serum soluble CD30 (sCD30) levels might be a useful marker of immunologic status in pre transplant (Tx) recipients. We retrospectively correlated preTx sCD30 levels (high versus low) on postTx graft survival, incidence of acute rejection, and graft function using stored preTx serum.


METHODS
Of 254 recipients who underwent kidney Tx, 120 recipients were enrolled under the uniform criteria (living donor, age >25 years, viral hepatitis free, diabetes free).


RESULTS
The preTx sCD30 was not significantly associated with differences in graft survival rate during 47.5+/-11.4 months of follow-up (P = 0.5901). High sCD30 (> or =115 U/ml) was associated with a higher incidence of clinically or pathologically defined acute rejection than low sCD30, but the difference was not statistically significant (33.9% vs. 22.4%, P = 0.164). The response rate to antirejection therapy in patients with high sCD30 was inferior to those with low sCD30, but also was not statistically significant (33.3% vs. 7.7%, P = 0.087). However, mean serum creatinine levels in high sCD30 patients at one month, one year, and three years postTx were significantly different from those with low sCD30 (P < 0.05). In multiple regression analysis, acute rejection episodes, donor age, kidney weight/recipient body weight ratio, and preTx sCD30 levels were independent variables affecting the serum creatinine level three years postTx.


CONCLUSIONS
PreTx sCD30 level has a limited effect on the incidence of acute rejection and response to antirejection treatment, but inversely and independently affects serum creatinine level after living donor kidney transplantation.
Kim
Myoung Soo
MS
Department of Surgery, Yonsei University College of Medicine, Seoul, South Korea.
Kim
Hae Jin
HJ
Kim
Soon Il
SI
Ahn
Hyung Joon
HJ
Ju
Man Ki
MK
Kim
Hyun Jung
HJ
Jeon
Kyung Ock
KO
Kim
Yu Seun
YS
D000328:Adult; D003404:Creatinine / Q000097:blood*; D005260:Female; D006084:Graft Rejection / Q000453:epidemiology*; D006085:Graft Survival / Q000276:immunology; D006801:Humans; D015994:Incidence; D017730:Ki-1 Antigen / Q000097:blood* / Q000276:immunology; D007668:Kidney / Q000502:physiology*; D016030:Kidney Transplantation / Q000276:immunology*; D019520:Living Donors; D008297:Male; D008875:Middle Aged
D017730:Ki-1 Antigen; D003404:Creatinine