Interaction between dopamine D1 and D2 receptors in modulation of the immune response.
The interaction between dopamine D1 and D2 receptors plays a role in immunomodulation. The results of thus interaction depends on the degree of receptor activation with selective agonists in different doses. Combined treatment with agonists of D1 and D2 receptors in high doses had a synergistic effect in the mechanisms of immunomodulation. Receptor agonists in low doses suppressed the immune response. Our results suggest that weak activation of one of these receptors is accompanied by inactivation of the other receptor type.
Devoino
L V
LV
Laboratory for Mechanisms of Neurochemical Modulation, Institute of Physiology, Siberian Division, Russian Academy of Medical Sciences, Novosibirsk.
Al'perina
E L
EL
Gevorgyan
M M
MM
Cheido
M A
MA
D015647:2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine / Q000494:pharmacology; D000818:Animals; D015259:Dopamine Agents / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D007155:Immunologic Factors / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D019257:Quinpirole / Q000494:pharmacology; D017447:Receptors, Dopamine D1 / Q000276:immunology* / Q000378:metabolism*; D017448:Receptors, Dopamine D2 / Q000276:immunology* / Q000378:metabolism*; D013154:Spleen / Q000276:immunology / Q000473:pathology
D015259:Dopamine Agents; D007155:Immunologic Factors; D017447:Receptors, Dopamine D1; D017448:Receptors, Dopamine D2; D019257:Quinpirole; D015647:2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine