Erythropoietin in cardiorenal anemia syndrome.
Incidents of heart and renal failure (HF, RF) together, are increasing in our country and all over the world, so a great attention has been dedicated to this problem recently. These diseases together have shown bad results because of the process of accelerated arteriosclerosis, structural changes of myocardium, oxidative stress, inflammation, increased activities of sympathetic nervous system (SNS), increased activities of a renin-angiotensin-aldosterone system (RAAS) (1). These factors are crucial in the development of patho-physiological process and consequential development of anemia, that together with heart and renal failure through interaction, cause serious disorder that we call the cardio-renal anemia syndrome (2). We examined effects of erythropoietin (Epoetin beta) at 90 (60 men and 30 women) pre-dialysed and dialysed patients with HF signs during a period of three years in individual dozes of 2000-6000 units subcutaneous (sc) weekly. Using computer S PLUS and SAS multiple variant analysis we have got correlations by Pearson. Epoetin beta significantly develops anemia parameters: number of erythrocytes (r=0.51779; p<0.0001), hemoglobin (r=0.38811; p<0.0002), MCV (r=0.59876; p<0.0001) at patients with HF. Positive effects are seen at NYHA class (r=0.59906; p<0.0001), on quality of life before and after prescribing medicine. Parameters of renal functions are improving: more urea (r =0.45557; p<0.0001) than creatinine (r=0.26397; p<0.00119) and potassium values K(+)) are not changed significantly (r=0.02060; p<0.8471). Epoetin beta has been useful in treatment of pre-dialysed and dialysed patients with HF and anemia by improving functional ability of myocardium and quality of life.
Fazlibegović
Emir
E
Clinical Hospital Mostar, Bijeli Brijeg, 88000 Mostar, Bosnia and Herzegovina.
Hadziomerović
Mustafa
M
Corić
Slavica
S
Babić
Emil
E
Fazlibegović
Fadila
F
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000740:Anemia / Q000188:drug therapy*; D001786:Blood Glucose / Q000378:metabolism; D001806:Blood Urea Nitrogen; D003404:Creatinine / Q000097:blood; D003583:Cytokinins / Q000097:blood / Q000502:physiology; D004906:Erythrocyte Count; D004921:Erythropoietin / Q000627:therapeutic use*; D005260:Female; D006331:Heart Diseases / Q000097:blood / Q000188:drug therapy*; D006410:Hematopoiesis / Q000502:physiology; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000473:pathology; D007676:Kidney Failure, Chronic / Q000097:blood / Q000188:drug therapy*; D008297:Male; D044342:Malnutrition / Q000150:complications; D008875:Middle Aged; D011188:Potassium / Q000097:blood; D011994:Recombinant Proteins; D006435:Renal Dialysis; D013577:Syndrome; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism / Q000502:physiology
D001786:Blood Glucose; D003583:Cytokinins; D006454:Hemoglobins; D011994:Recombinant Proteins; D014409:Tumor Necrosis Factor-alpha; D004921:Erythropoietin; D003404:Creatinine; D011188:Potassium