title: [Epithelial advanced ovarian carcinoma in the central region of Tunisia: therapeutic results and prognostic factors on 104 patients].
abstract: Between 1994 and 2004, 104 patients with epithelial advanced ovarian cancer were treated in the central region of Tunisia (81 stage III and 23 stage IV). Average age of patients was 54 years. Primary surgery was optimal (residue < 2 cm) in 40 cases (38,5 % of patients). Fifty nine patients were treated with neo adjuvant chemotherapy based on platinum, associated to paclitaxel in 19 % of cases. Interval debulking surgery interested 30 patients and was optimal in 66,7 % of cases. Global survive was 57 % at 2 years and 27 % at 5 years. Survival rate for patients treated with optimal debulking surgery was similar to that of those treated with initial optimal surgery. Prognostic factors for a better survive were : age < 40 years (p < 0,05), stage III (p < 0,01), a normal level of CA125 after surgery (p < 0,01), primary optimal initial surgery (p < 0,02) and response to neoadjuvant chemotherapy (p < 0,01). Prognosis of ovarian carcinoma is worse in Tunisia as like as in the world. In case of extensive tumor, the neoadjuvant chemotherapy before interval debulking surgery permits to improve survive and quality of life in some patients.
authors.affiliation: Service de médecine carcinologique, CHU Farhat-Hached, Sousse, Tunisie. Leila.BenFatma@famso.rnu.tn
authors.forename: Leila
authors.initials: L
authors.lastname: Ben Fatma
authors.forename: Makram
authors.initials: M
authors.lastname: Hochlef
authors.forename: Olfa
authors.initials: O
authors.lastname: Gharbi
authors.forename: Amel
authors.initials: A
authors.lastname: Landolsi
authors.forename: Sami
authors.initials: S
authors.lastname: Limam
authors.forename: Imene
authors.initials: I
authors.lastname: Chabchoub
authors.forename: Nadra
authors.initials: N
authors.lastname: Cherif
authors.forename: Sassi
authors.initials: S
authors.lastname: Bouguizene
authors.forename: Tahar
authors.initials: T
authors.lastname: Yacoubi
authors.forename: Mohamed
authors.initials: M
authors.lastname: Bibi
authors.forename: Hedi
authors.initials: H
authors.lastname: Khairi
authors.forename: Slim
authors.initials: S
authors.lastname: Ben Ahmed
mesh_terms: D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D002277:Carcinoma / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D017024:Chemotherapy, Adjuvant; D005260:Female; D006801:Humans; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D010051:Ovarian Neoplasms / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D011379:Prognosis; D012189:Retrospective Studies; D014416:Tunisia