title: Oppositines A and B, sesquiterpene pyridine alkaloids from a Sri Lankan Pleurostylia opposita.
abstract: Two new sesquiterpene pyridine alkaloids, oppositines A (1) and B (2), have been isolated from the plant Pleurostylia opposita, collected in Sri Lanka. The compounds were isolated and purified by solvent/solvent partitioning, column chromatography, and HPLC. Their structures were assigned on the basis of extensive 1D and 2D NMR studies as well as analysis by HRESIMS. Oppositines A (1) and B (2) showed moderate cytotoxicity against HCT116 cell lines with EC50 values of 27 +/- 2 and 26 +/- 3 microM, respectively.
authors.affiliation: Department of Medicinal Chemistry, University of Utah, Salt Lake City, UT 84112, USA.
authors.forename: Emily L
authors.initials: EL
authors.lastname: Whitson
authors.forename: S M V Damayanthi
authors.initials: SM
authors.lastname: Mala
authors.forename: Charles A
authors.initials: CA
authors.lastname: Veltri
authors.forename: Tim S
authors.initials: TS
authors.lastname: Bugni
authors.forename: E Dilip
authors.initials: ED
authors.lastname: de Silva
authors.forename: Chris M
authors.initials: CM
authors.lastname: Ireland
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D029753:Celastraceae / Q000737:chemistry*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013188:Sri Lanka
chemical_list: D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D012717:Sesquiterpenes; C516373:oppositine A; C516374:oppositine B