title: Getting axons onto the right path: the role of transcription factors in axon guidance.
abstract: The normal function of the nervous system requires that the constituent neurons are precisely 'wired together'. During embryogenesis, each neuron extends an axonal process, which can navigate a considerable distance to its target. Although a number of the receptors and guidance signals that direct axonal growth have been identified, less is known about the transcription factors that regulate the expression of these molecules within the neuron and its environment. This review examines recent studies in vertebrates and Drosophila that address the identity of the transcription factors that either control the repertoire of guidance receptors and signals that permits an axon to take a particular trajectory or act themselves as novel extracellular guidance factors.
authors.affiliation: Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA.
authors.forename: Samantha J
authors.initials: SJ
authors.lastname: Butler
authors.forename: Guy
authors.initials: G
authors.lastname: Tear
mesh_terms: D000818:Animals; D001369:Axons / Q000502:physiology* / Q000648:ultrastructure; D004330:Drosophila / Q000502:physiology / Q000648:ultrastructure; D029721:Drosophila Proteins / Q000502:physiology; D018398:Homeodomain Proteins / Q000502:physiology; D008959:Models, Neurological; D009419:Nerve Tissue Proteins / Q000502:physiology; D009420:Nervous System / Q000254:growth & development*; D014157:Transcription Factors / Q000502:physiology*; D014714:Vertebrates
chemical_list: D029721:Drosophila Proteins; D018398:Homeodomain Proteins; D009419:Nerve Tissue Proteins; D014157:Transcription Factors