title: Eudesmane derivatives from Hieracium intybaceum.
abstract: Two new eudesmanolides, 4beta-H,3beta-(beta-D-glucopyranosyloxy)eudesma-1,11(13)-dien-12,6-olide (5a) and 3beta-D-glucopyranosyloxyeudesma-1,4(15),11(13)-trien-12,6-olide (5b), as well as two related, known compounds, tuberiferin (7a) and dehydrobrachylaenolide (7b), were isolated from the CH2Cl2 extract of subaerial parts of Hieracium intybaceum All. Compounds 6a, 6b, 8a, and 8b, the Me esters of the corresponding sesquiterpenic acids related to 5a, 5b, 7a, and 7b, respectively, were obtained as artifacts during the isolation process. Additionally, linoleic acid (1), linolenic acid (2), the lignane syringaresinol 4'-O-beta-D-glucopyranoside (3), and the guaianolide dehydrocostus lactone (4) were also isolated from H. intybaceum. Structure elucidations were based on mass spectrometry and extensive 1D- and 2D-NMR spectroscopy.
authors.affiliation: Institut für Pharmazie, Abteilung Pharmakognosie, Leopold-Franzens-Universität Innsbruck, Innrain 52, Josef-Moeller-Haus, A-6020 Innsbruck.
authors.forename: Sandra
authors.initials: S
authors.lastname: Grass
authors.forename: Christian
authors.initials: C
authors.lastname: Zidorn
authors.forename: Ernst P
authors.initials: EP
authors.lastname: Ellmerer
authors.forename: Hermann
authors.initials: H
authors.lastname: Stuppner
mesh_terms: D019659:Asteraceae; D035261:Plant Components, Aerial; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification; D045787:Sesquiterpenes, Eudesmane / Q000737:chemistry* / Q000302:isolation & purification*
chemical_list: D010936:Plant Extracts; D045787:Sesquiterpenes, Eudesmane; C015872:eudesmane