title: The "domino theory" of hunger: the hypothalamus is hot.
abstract: Mechanisms by which the hypothalamus senses nutritional status are important for many metabolic diseases, including obesity and diabetes. Now, report that hypothalamic neurons sense nutritional deficit through a cascade of events involving leptin, corticosterone, and glial production of thyroid hormone, leading to neuronal induction of uncoupling protein.
authors.affiliation: Department of Neuroscience and Department of Geriatrics, Mount Sinai School of Medicine, New York, NY 10029, USA. charles.mobbs@mssm.edu
authors.forename: Charles V
authors.initials: CV
authors.lastname: Mobbs
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D004734:Energy Metabolism; D005215:Fasting; D006815:Hunger; D007031:Hypothalamus / Q000166:cytology / Q000378:metabolism*; D007473:Ion Channels / Q000378:metabolism; D020738:Leptin / Q000378:metabolism; D051379:Mice; D024101:Mitochondrial Proteins / Q000378:metabolism; D009474:Neurons / Q000378:metabolism*; D022722:Thermogenesis; D014284:Triiodothyronine / Q000378:metabolism; D000071246:Uncoupling Protein 2
chemical_list: D007473:Ion Channels; D020738:Leptin; D024101:Mitochondrial Proteins; D000071246:Uncoupling Protein 2; D014284:Triiodothyronine; D000255:Adenosine Triphosphate