Radical-scavenging activities of new hydroxylated ursane triterpenes from cv. Annurca apples.
Two new ursolic acid triterpene derivatives, compounds 2 and 3, have been isolated from cv. Annurca apple fruit, a high-quality apple variety widely cultivated in southern Italy, together with the known 2-oxopomolic acid (1). The new compounds were identified by means of different spectroscopic techniques as 3-epi-2-oxopomolic acid (= (3alpha)-3,19-dihydroxy-2-oxours-12-en-28-oic acid; 2) and (1alpha)-1-hydroxy-3-oxours-12-en-28-oic acid (3). Compounds 1-3 were tested for their radical-scavenging activities with the aid of a 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay (Fig. 2). All three constituents showed activities similar to that of the reference antioxidant alpha-tocopherol (vitamin E).
D'Abrosca
Brigida
B
Dipartimento di Scienze della Vita, Seconda Università degli Studi di Napoli, via Vivaldi 43, I-81100 Caserta.
Fiorentino
Antonio
A
Monaco
Pietro
P
Pacifico
Severina
S
D016166:Free Radical Scavengers / Q000737:chemistry*; D005638:Fruit / Q000737:chemistry*; D027845:Malus / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism; D014315:Triterpenes / Q000737:chemistry*
C516968:1-hydroxy-3-oxours-12-en-28-oic acid; C412808:2-oxopomolic acid; D016166:Free Radical Scavengers; D014315:Triterpenes