title: Histopathologic abnormalities of the lymphoreticular tissues in organic cation transporter 2 deficiency: evidence for impaired B cell maturation.
abstract: Immunohistology of lymphoreticular tissues of a fatal case of organic cation transporter 2 deficiency revealed inhibited proliferation with increased apoptosis in the germinal centers, resulting in "burned out" follicles. This is indicative of impaired antigen driven B cell affinity maturation. Defective humoral immune response might explain the recurrent infections in untreated organic cation transporter 2 deficiency.
authors.affiliation: Department of Medical Genetics and Child Development, University of Pécs, Pécs, Hungary.
authors.forename: Katalin
authors.initials: K
authors.lastname: Komlósi
authors.forename: Viktória
authors.initials: V
authors.lastname: Havasi
authors.forename: Judit
authors.initials: J
authors.lastname: Bene
authors.forename: Norbert
authors.initials: N
authors.lastname: Süle
authors.forename: László
authors.initials: L
authors.lastname: Pajor
authors.forename: Raffaella
authors.initials: R
authors.lastname: Nicolai
authors.forename: Paola
authors.initials: P
authors.lastname: Benatti
authors.forename: Menotti
authors.initials: M
authors.lastname: Calvani
authors.forename: Béla
authors.initials: B
authors.lastname: Melegh
mesh_terms: D001402:B-Lymphocytes / Q000473:pathology*; D049108:Cell Enlargement; D049109:Cell Proliferation; D002675:Child, Preschool; D018450:Disease Progression; D006801:Humans; D007223:Infant; D008221:Lymphoid Tissue / Q000378:metabolism / Q000473:pathology*; D008297:Male; D027701:Organic Cation Transport Proteins / Q000172:deficiency*; D012141:Respiratory Tract Infections / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D000074058:Solute Carrier Family 22 Member 5
chemical_list: D027701:Organic Cation Transport Proteins; C492020:SLC22A5 protein, human; D000074058:Solute Carrier Family 22 Member 5