Two new taxoids from Taxus chinensis.
Two new taxoids, 2,20-O-diacetyltaxumairol N (1) and 14beta-hydroxy-10-deacetyl-2-O-debenzoylbacatin III (2), were isolated from the needles and stems of Taxus chinensis. Their structures were determined on the basis of extensive 1D- and 2D-NMR-spectral analysis. Compound 1 showed weak cytotoxicity activity against T-24 (IC50 = 34 microg/ml) and QGY-7701 (IC50 = 22 microg/ml) cancer lines. Compound 2 showed no obvious cytotoxicity activity against T-24 (IC50 > 100 microg/ml) and QGY-7701 (IC50 > 100 microg/ml) cancer lines.
Xia
Zhi-Hua
ZH
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan 650204, PR China.
Peng
Li-Yan
LY
Zhao
Yu
Y
Xu
Gang
G
Zhao
Qin-Shi
QS
Sun
Han-Dong
HD
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D043823:Taxoids / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D020946:Taxus / Q000737:chemistry*
C517883:14-hydroxy-10-deacetyl-2-O-debenzoylbacatin III; C517882:2,20-O-diacetyltaxumairol N; D000972:Antineoplastic Agents, Phytogenic; D043823:Taxoids