title: Comparison of methylprednisolone and ketoprofen after multiple third molar extraction: a randomized controlled study.
abstract: In a prospective, double blind, and randomized study, we compared methylprednisolone and ketoprofen after anesthesia for multiple third molar extraction. In addition to paracetamol, 90 patients were allocated to receive intravenously either ketoprofen 100 mg or methylprednisolone 1 mg/kg. Severity of pain was measured with visual analogue scale (VAS) in recovery room. Sixty-three percent of patients receiving methylprednisolone had a VAS score <30 mm compared with 42% of those receiving ketoprofen (P = 0.04), with no difference in the consumption of morphine. We observed only marginal difference between methylprednisolone and ketoprofen to relieve pain after this surgery.
authors.affiliation: Department of Intensive Care Medicine and Trauma Center, Centre Hospitalier et Universitaire Nord, Marseille, France. marc.leone@ap-hm.fr
authors.forename: Marc
authors.initials: M
authors.lastname: Leone
authors.forename: Olivier
authors.initials: O
authors.lastname: Richard
authors.forename: François
authors.initials: F
authors.lastname: Antonini
authors.forename: Sébastien
authors.initials: S
authors.lastname: Rousseau
authors.forename: Wajdi
authors.initials: W
authors.lastname: Chabaane
authors.forename: Laurent
authors.initials: L
authors.lastname: Guyot
authors.forename: Claude
authors.initials: C
authors.lastname: Martin
mesh_terms: D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D004487:Edema / Q000517:prevention & control*; D004812:Epidemiologic Methods; D005260:Female; D006801:Humans; D007660:Ketoprofen / Q000627:therapeutic use*; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use*; D008964:Molar, Third / Q000601:surgery*; D010147:Pain Measurement; D010149:Postoperative Pain / Q000188:drug therapy*; D014081:Tooth Extraction / Q000009:adverse effects
chemical_list: D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D007660:Ketoprofen; D008775:Methylprednisolone