title: Addison's disease due to adrenal tuberculosis: contrast-enhanced CT features and clinical duration correlation.
abstract: OBJECTIVE
  To describe CT morphology of untreated adrenal tuberculosis during the different stages of the natural history of the disease and to evaluate the diagnostic implications of CT features.
  
  
  METHODS
  We retrospectively evaluated CT features in 42 patients with documented adrenal tuberculosis for the location, size, morphology, and enhancement patterns shown on CT images. The clinical duration were correlated with the CT features.
  
  
  RESULTS
  Of the 42 patients with untreated adrenal tuberculosis, bilaterally enlarged adrenal glands were revealed in 38 cases (91%), unilaterally enlarged in 3 cases (7%), and normal size in 1 case (2%). Of the 41 cases (98%) with enlargement, mass-like enlargement was seen in 20 cases (49%) and enlargement with preserved contours in 21 cases (51%). Peripheral rim enhancement presented in 22 cases (52%) on contrast-enhanced CT. Non-enhanced CT scan revealed calcification in 21 cases (50%). As the duration of Addison's disease increased, the presence of calcification and contour preservation increased concomitantly (p<0.001), whereas peripheral rim enhancement and mass-like enlargement decreased concomitantly on CT images (p<0.001).
  
  
  CONCLUSIONS
  CT may be helpful in diagnosing adrenal tuberculosis when clinically suspected, and CT features are correlated to the clinical duration of Addison's disease.
authors.affiliation: Department of Radiology, West China Hospital, Sichuan University, #37 Guo Xue Xiang, Chengdu, Sichuan 610041, China.
authors.forename: Ying-Kun
authors.initials: YK
authors.lastname: Guo
authors.forename: Zhi-Gang
authors.initials: ZG
authors.lastname: Yang
authors.forename: Yuan
authors.initials: Y
authors.lastname: Li
authors.forename: En-Sen
authors.initials: ES
authors.lastname: Ma
authors.forename: Yu-Ping
authors.initials: YP
authors.lastname: Deng
authors.forename: Peng-Qiu
authors.initials: PQ
authors.lastname: Min
authors.forename: Long-Lin
authors.initials: LL
authors.lastname: Yin
authors.forename: Jian
authors.initials: J
authors.lastname: Hu
authors.forename: Xiao-Chun
authors.initials: XC
authors.lastname: Zhang
authors.forename: Tian-Wu
authors.initials: TW
authors.lastname: Chen
mesh_terms: D000224:Addison Disease / Q000000981:diagnostic imaging* / Q000382:microbiology*; D000307:Adrenal Gland Diseases / Q000150:complications* / Q000000981:diagnostic imaging*; D000328:Adult; D000368:Aged; D003287:Contrast Media; D006801:Humans; D007472:Iohexol / Q000031:analogs & derivatives; D016014:Linear Models; D008875:Middle Aged; D015203:Reproducibility of Results; D014057:Tomography, X-Ray Computed / Q000379:methods*; D014383:Tuberculosis, Endocrine / Q000150:complications* / Q000000981:diagnostic imaging*
chemical_list: D003287:Contrast Media; D007472:Iohexol; C038192:iopromide