Importance of the trans-sulfuration pathway in cancer prevention and promotion.
The trans-sulfuration pathway is a biochemical mechanism that links methionine metabolism to the biosynthesis of cellular redox-controlling molecules, like cysteine, glutathione, and taurine. While there is some knowledge about the metabolic intermediates and enzymes that participate in trans-sulfuration, little is known about the physiological importance of this mechanism. Deficiencies within the trans-sulfuration pathway induces (i) the generation of reactive species of oxygen (ROS) and halogens (RHS), (ii) homocyst(e)ine accumulation, and (iii) the synthesis of proinflammatory molecules by macrophages, and contribute to humans pathologies like atherosclerosis and tumor development. In this review we outline the role of this biochemical pathway in tumor development and analyze current findings on the role of trans-sulfuration in mammalian physiology. The potential relationship between chronic inflammation, and tumor and atherosclerotic development are discussed.
Rosado
Joemerson Osório
JO
Instituto de Biotecnologia/Departamento de Ciências Biomédicas, Laboratório de Genética Toxicológica-206, Universidade de Caxias do Sul, Rua Francisco Getúlio Vargas 1130-Bloco 57, Caxias do Sul, RS, Brazil.
Salvador
Mirian
M
Bonatto
Diego
D
D043383:Adenosylhomocysteinase / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D003541:Cystathionine beta-Synthase / Q000378:metabolism; D003542:Cystathionine gamma-Lyase / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism; D006801:Humans; D008715:Methionine / Q000378:metabolism*; D008958:Models, Molecular; D008969:Molecular Sequence Data; D009369:Neoplasms / Q000378:metabolism / Q000503:physiopathology / Q000517:prevention & control; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D011487:Protein Conformation; D013455:Sulfur / Q000378:metabolism*; D013654:Taurine / Q000378:metabolism
D013654:Taurine; D013455:Sulfur; D008715:Methionine; D043383:Adenosylhomocysteinase; D003541:Cystathionine beta-Synthase; D003542:Cystathionine gamma-Lyase; D005978:Glutathione