Primary rhabdomyosarcoma of the breast in a 13-year-old girl: report of a case.
We report a case of primary alveolar rhabdomyosarcoma of the breast in a 13-year-old Japanese girl. The patient initially presented with a 13 x 8-cm mass in her left breast, which was diagnosed as alveolar rhabdomyosarcoma after an excisional biopsy. Genetic expression of the tumor revealed t(2;13)(q35-37;q14). She underwent modified radical mastectomy (Bt + Ax) and nine lymph nodes were found to be involved. Systemic examinations showed multiple bone and lung metastases 2 weeks after her operation. Despite chemotherapy with doxorubicin, ifosfamide, and actinomycin D, which resulted in remission for 6 months, she died of the disease 8 months after surgery.
Nogi
Hiroko
H
Department of Breast and Endocrine Surgery, Jikei University School of Medicine, 3-25-8 Nishi-shinbashi, Tokyo 105-8461, Japan.
Kobayashi
Tadashi
T
Kawase
Kazumi
K
Tabei
Isao
I
Toriumi
Yasuo
Y
Suzuki
Masafumi
M
Kawakami
Makio
M
Morikawa
Toshiaki
T
Uchida
Ken
K
D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001859:Bone Neoplasms / Q000556:secondary*; D001943:Breast Neoplasms / Q000235:genetics / Q000473:pathology* / Q000628:therapy; D003609:Dactinomycin / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007069:Ifosfamide / Q000008:administration & dosage; D008175:Lung Neoplasms / Q000556:secondary*; D008408:Mastectomy; D018232:Rhabdomyosarcoma, Alveolar / Q000235:genetics / Q000473:pathology* / Q000628:therapy
D003609:Dactinomycin; D004317:Doxorubicin; D007069:Ifosfamide