Synthesis, spectral properties, and antitumor activity of a new axially substituted phthalocyanine complex of zirconium(IV) with citric acid.
The new axially substituted phthalocyanine (pc) complex of zirconium(IV) with citric acid is reported. It has been shown that the replacement of two Cl-atoms with two citric acid fragments takes place as the result of the reaction between [ZrCl2(pc)] and citric acid. The complex [Zr(citrate)2(pc)] was formed. The spectroscopic properties of the synthesized compound in DMSO, RPMI 1640 medium with and without fetal calf serum (FCS), H2O, and buffer (Tris) solutions have been described. Antitumor activity of this compound has been studied. The cytostatic activity was observed in the concentration range of 6.1-9.0x10(9) molecules [Zr(citrate)2(pc)]/cell and occurred in 4-6 h after treatment with [Zr(citrate)2(pc)] solution.
Tomachynski
Larisa A
LA
V.I. Vernadskii Institute of General & Inorganic Chemistry, 32/34, Prospect Palladina, Kiev-142, 03680, Ukraine.
Chernii
Victor Y
VY
Gorbenko
Helena N
HN
Filonenko
Valeriy V
VV
Volkov
Sergey V
SV
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D045744:Cell Line, Tumor; D019343:Citric Acid / Q000138:chemical synthesis* / Q000494:pharmacology; D007211:Indoles / Q000138:chemical synthesis* / Q000494:pharmacology; D054833:Isoindoles; D051379:Mice; D013057:Spectrum Analysis; D013237:Stereoisomerism; D015040:Zirconium / Q000737:chemistry* / Q000494:pharmacology
D000970:Antineoplastic Agents; D007211:Indoles; D054833:Isoindoles; D019343:Citric Acid; D015040:Zirconium; C013647:phthalocyanine