Preparation and characterization of solid dispersions of piroxicam with hydrophilic carriers.
The objective of this study was to improve the dissolution rate of a poor water soluble drug, piroxicam, by solid dispersion technique. Solid dispersions were prepared by three different methods depending on the type of carrier. The dissolution rate of piroxicam was markedly increased in solid dispersion of myrj 52, Eudragit E100 and mannitol. Solubility studies revealed a marked increase in the solubility of piroxicam with an increase in myrj 52 and Eudragit E100 concentrations. Data from the X-ray diffraction and FT-IR spectroscopy showed that piroxicam was amorphous in the solid dispersions prepared with dextrin and Eudragit E100.
Valizadeh
Hadi
H
Department of Pharmaceutics, Tabriz University of Medical Sciences, Tabriz, Iran. valizadeh@tbzmed.ac.ir
Zakeri-Milani
Parvin
P
Barzegar-Jalali
Mohammad
M
Mohammadi
Ghobad
G
Danesh-Bahreini
Mohammad-Ali
MA
Adibkia
Khosro
K
Nokhodchi
Ali
A
D000179:Acrylates / Q000008:administration & dosage; D004337:Drug Carriers; D006863:Hydrogen-Ion Concentration; D010894:Piroxicam / Q000008:administration & dosage* / Q000737:chemistry; D011108:Polymers / Q000008:administration & dosage; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared; D014961:X-Ray Diffraction
D000179:Acrylates; D004337:Drug Carriers; C477020:Eudragit E100; D011108:Polymers; D010894:Piroxicam