[Adenocarcinomas of the ethmoid sinus: retrospective analysis of prognostic factors].
OBJECTIVE
Determinate the different prognostic factors of survival in ethmoidal sinus adenocarcinomas (ADK).


METHODS
60 patients with ethmoidal sinus ADK. 59 men and one woman. Average of 62.2 years (41-82). Retrospective study between 1985 and 2005. The following data were analyzed: exposure time to wood dust, disease incidence, primary clinical symptoms and ASA score. Radiological data were recovered by tomodensitometry and magnetic resonance imaging. Histological groups were described. TNM classification according to UICC 2002 and Roux/Brasnu was established on clinical and radiological constatations. Different treatments used were analyzed. Estimate of survival rate and impact of different prognostic factors were based on Kaplan-Meier actuarial method and multivariate analysis.


RESULTS
Incidence rate was 2.86 patients a year. Exposure average time to wood dust was 25.6 years (2-44). T3/T4 stages were predominant (66.7%). the survival rate was 46.5% at 5 years. The survival rate was significantly superior respectively in T1 and T2 stages than in T3 and T4 stages, and in T4a than in T4b stages. Extension of the lesion to the sphenoid sinus was revealed as a significant bad prognostic factor. The ASA score and the exposure time to wood dust were not identified as statistically significant prognosis factors.


CONCLUSIONS
Survival factors of ethmoïd sinus ADK were T stage and the extension of the tumor to the sphenoid sinus. On the results of this study, we consider that extension in sphenoïd sinus could be include in TNM classification of ethmoïd sinus adenocarcinomas.
Liétin
B
B
Service d'ORL et de Chirurgie de la face et du cou, Centre hospitalier universitaire, BP 69 63003 Clermont-Ferrand Cedex 1.
Mom
T
T
Avan
P
P
Llompart
X
X
Kemeny
J-L
JL
Chazal
J
J
Russier
M
M
Gilain
L
L
D000230:Adenocarcinoma / Q000175:diagnosis* / Q000209:etiology / Q000401:mortality / Q000628:therapy; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004391:Dust; D005005:Ethmoid Sinus; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009784:Occupational Diseases / Q000175:diagnosis* / Q000209:etiology / Q000401:mortality / Q000628:therapy; D016273:Occupational Exposure / Q000009:adverse effects; D010255:Paranasal Sinus Neoplasms / Q000175:diagnosis* / Q000209:etiology / Q000401:mortality / Q000628:therapy; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D015996:Survival Rate; D014934:Wood / Q000009:adverse effects
D004391:Dust