title: Ramosetron versus ondansetron in the prevention of chemotherapy-induced gastrointestinal side effects: A prospective randomized controlled study.
abstract: BACKGROUND
  This study observed and compared the preventive effects of ramosetron and ondansetron on gastrointestinal side effects caused by cisplatin-containing chemotherapy.
  
  
  METHODS
  Fifty patients with malignant tumors undergoing their first chemotherapy were randomly divided into two groups, and each group received 0.3 mg of ramosetron and 16 mg of ondansetron in a prospective crossover comparison study.
  
  
  RESULTS
  Data were collected for analysis of the therapeutic effect in 47 cases and for adverse events in 50 cases. Both drugs showed similar results in regard to chemotherapy-induced gastrointestinal side effects, emesis and appetite loss on day 1, but by day 5, ramosetron was significantly better than ondansetron in terms of controlling appetite loss. From days 3-5, ramosetron tended to be more effective than ondansetron in its antiemetic action. The incidence of headache, fatigue and constipation was the same for both drugs.
  
  
  CONCLUSIONS
  Ramosetron is a long-lasting and safe antiemetic agent.
authors.affiliation: Department of Medical Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. syk@pubem.cicams.ac.cn
authors.forename: Yuankai
authors.initials: Y
authors.lastname: Shi
authors.forename: Xiaohui
authors.initials: X
authors.lastname: He
authors.forename: Sheng
authors.initials: S
authors.lastname: Yang
authors.forename: Bin
authors.initials: B
authors.lastname: Ai
authors.forename: Changgong
authors.initials: C
authors.lastname: Zhang
authors.forename: Dingzhi
authors.initials: D
authors.lastname: Huang
authors.forename: Mei
authors.initials: M
authors.lastname: Dong
authors.forename: Peng
authors.initials: P
authors.lastname: Liu
authors.forename: Shengyu
authors.initials: S
authors.lastname: Zhou
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Han
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000855:Anorexia / Q000139:chemically induced / Q000517:prevention & control*; D000932:Antiemetics / Q000009:adverse effects / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D001562:Benzimidazoles / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009325:Nausea / Q000139:chemically induced / Q000517:prevention & control*; D009369:Neoplasms / Q000188:drug therapy; D017294:Ondansetron / Q000009:adverse effects / Q000627:therapeutic use*; D014839:Vomiting / Q000139:chemically induced / Q000517:prevention & control*
chemical_list: D000932:Antiemetics; D001562:Benzimidazoles; D017294:Ondansetron; C071315:ramosetron