The histopathological effect of intracameral ropivacaine in different concentrations on corneal endothelium.
We evaluated the histopathological changes occurring in corneal endothelium after intracameral injection ropivacaine into rats. Intracamerally administered ropivacaine in 1, 0.5, and 0.1% concentrations resulted in impairment of hexagonal structure of corneal endothelial cells and intercellular junctions, destruction of microvilli on the cell surface, roughness of cell borders, picnotic nucleus, diffuse vacuolization, and crystalysis in mitochondria.
Caça
Ihsan
I
Department of Ophthalmology, Dicle University Faculty of Medicine, Diyarbakir, Turkey. ihsancaca@mynet.com
Kavak
Vatan
V
Unlü
Kaan
K
Ari
Seyhmus
S
Nergis
Yusuf
Y
Take
Gülnür
G
D000577:Amides / Q000008:administration & dosage / Q000633:toxicity*; D000779:Anesthetics, Local / Q000008:administration & dosage / Q000633:toxicity*; D000818:Animals; D000867:Anterior Chamber / Q000187:drug effects*; D004728:Endothelium, Corneal / Q000187:drug effects* / Q000648:ultrastructure*; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D051381:Rats; D017208:Rats, Wistar; D000077212:Ropivacaine
D000577:Amides; D000779:Anesthetics, Local; D000077212:Ropivacaine