title: Left extended hepatectomy for a metastatic gastrointestinal stromal tumor after a disease-free interval of 17 years: report of a case.
abstract: Gastrointestinal stromal tumors (GISTs), although rare, are frequently diagnosed with liver metastasis. These metastatic GISTs are poorly responsive to conventional chemotherapy; however, recent studies report improved survival after complete surgical resection of liver metastases. On the other hand, few reports describe the treatment of delayed liver metastasis after resection of a primary GIST. We report the case of a 55-year-old woman found to have liver metastasis from a GIST after a 17-year disease-free interval. The patient underwent a left extended hepatectomy for a complete resection of the metastatic GIST and is alive and well 30 months later. To our knowledge, this is the longest disease-free interval reported in the literature, and emphasizes the importance of considering late metastasis when evaluating patients with a history of GIST. Thus, surgical resection of delayed liver metastasis from a GIST should be considered as primary therapy.
authors.affiliation: Division of Hepatobiliary/Pancreatic Surgery and Abdominal Organ Transplantation, Keck School of Medicine, University of Southern California, University Hospital, 1510 San Pablo Street, HCC Suite 200, Los Angeles, CA 90033, USA.
authors.forename: Lea
authors.initials: L
authors.lastname: Matsuoka
authors.forename: Maria
authors.initials: M
authors.lastname: Stapfer
authors.forename: Rod
authors.initials: R
authors.lastname: Mateo
authors.forename: Nicolas
authors.initials: N
authors.lastname: Jabbour
authors.forename: Win
authors.initials: W
authors.lastname: Naing
authors.forename: Rick
authors.initials: R
authors.lastname: Selby
authors.forename: Singh
authors.initials: S
authors.lastname: Gagandeep
mesh_terms: D005260:Female; D046152:Gastrointestinal Stromal Tumors / Q000556:secondary / Q000601:surgery*; D006498:Hepatectomy; D006801:Humans; D007580:Jejunal Neoplasms / Q000473:pathology* / Q000601:surgery; D008113:Liver Neoplasms / Q000556:secondary / Q000601:surgery*; D008875:Middle Aged; D012186:Retroperitoneal Neoplasms / Q000473:pathology* / Q000601:surgery; D013997:Time Factors