title: DHLAS: A web-based information system for statistical genetic analysis of HLA population data.
abstract: DHLAS (database HLA system) is a user-friendly, web-based information system for the analysis of human leukocyte antigens (HLA) data from population studies. DHLAS has been developed using JAVA and the R system, it runs on a Java Virtual Machine and its user-interface is web-based powered by the servlet engine TOMCAT. It utilizes STRUTS, a Model-View-Controller framework and uses several GNU packages to perform several of its tasks. The database engine it relies upon for fast access is MySQL, but others can be used a well. The system estimates metrics, performs statistical testing and produces graphs required for HLA population studies: (i) Hardy-Weinberg equilibrium (calculated using both asymptotic and exact tests), (ii) genetics distances (Euclidian or Nei), (iii) phylogenetic trees using the unweighted pair group method with averages and neigbor-joining method, (iv) linkage disequilibrium (pairwise and overall, including variance estimations), (v) haplotype frequencies (estimate using the expectation-maximization algorithm) and (vi) discriminant analysis. The main merit of DHLAS is the incorporation of a database, thus, the data can be stored and manipulated along with integrated genetic data analysis procedures. In addition, it has an open architecture allowing the inclusion of other functions and procedures.
authors.affiliation: Department of Biomathematics, University of Thessaly School of Medicine, Papakyriazi 22, Larissa 41222, Greece.
authors.forename: P
authors.initials: P
authors.lastname: Thriskos
authors.forename: E
authors.initials: E
authors.lastname: Zintzaras
authors.forename: A
authors.initials: A
authors.lastname: Germenis
mesh_terms: D030541:Databases, Genetic; D006115:Greece; D006680:HLA Antigens / Q000235:genetics*; D006801:Humans; D020407:Internet; D014584:User-Computer Interface
chemical_list: D006680:HLA Antigens