[Determination of methamphetamine in whole blood by capillary zone electrophoresis after solid phase extraction].
OBJECTIVE
To develop a specific CZE method for the determination of methamphetamine in whole blood after solid phase extraction.


METHODS
With the doxapram as internal standard, Oasis column was used to extract drugs from whole blood and the sample was analysized by CZE.


RESULTS
The method showed excellent linearity and the linear correlation coefficient was 0.994. The relative standard deviation for between-day and within-day were 5.31% and 2.22%, respectively.


CONCLUSIONS
The method is effective, simple, reliable and has been used in the determination of methamphetamine in whole blood.
Gong
Fei-Jun
FJ
Shanghai Institute of Criminal Science and Technology, Shanghai 200083, China.
Zhang
Run-Sheng
RS
D004315:Doxapram / Q000737:chemistry; D019075:Electrophoresis, Capillary / Q000295:instrumentation / Q000379:methods*; D005554:Forensic Medicine; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D008694:Methamphetamine / Q000097:blood* / Q000302:isolation & purification / Q000506:poisoning; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D052616:Solid Phase Extraction; D012997:Solvents / Q000737:chemistry
D012997:Solvents; D008694:Methamphetamine; D004315:Doxapram