title: Associations between connexin37 gene polymorphism and markers of subclinical atherosclerosis: the Cardiovascular Risk in Young Finns study.
abstract: OBJECTIVE
  Connexin37 (cx37) C1019T polymorphism has been shown to associate with coronary artery disease in different populations. We investigated whether this polymorphism associates with carotid artery intima-media thickness (IMT), carotid artery compliance (CAC) and brachial artery flow mediated dilatation (FMD) - i.e., early ultrasound markers of subclinical atherosclerosis - in a clinically healthy population of young Finnish adults.
  
  
  RESULTS
  1440 individuals from the Cardiovascular Risk in Young Finns study were genotyped and studied using cardiovascular risk factor and ultrasound data obtained in 2001. In linear regression models, no significant association between the cx37 polymorphism and carotid IMT, CAC or brachial artery FMD (ANOVA, p=0.159, 0.151 and 0.547), respectively, was found in the whole population or in women and men separately.
  
  
  CONCLUSIONS
  The connexin37 C1019T polymorphism is not related with markers of subclinical atherosclerosis in young adults.
authors.affiliation: Laboratory of Atherosclerosis Genetics, Centre for Laboratory Medicine, Tampere University Hospital, Tampere University Medical School, Finland. Auni.Collings@psghp.fi
authors.forename: Auni
authors.initials: A
authors.lastname: Collings
authors.forename: Md Shaheenul
authors.initials: MS
authors.lastname: Islam
authors.forename: Markus
authors.initials: M
authors.lastname: Juonala
authors.forename: Riikka
authors.initials: R
authors.lastname: Rontu
authors.forename: Mika
authors.initials: M
authors.lastname: Kähönen
authors.forename: Nina
authors.initials: N
authors.lastname: Hutri-Kähönen
authors.forename: Tomi
authors.initials: T
authors.lastname: Laitinen
authors.forename: Jukka
authors.initials: J
authors.lastname: Marniemi
authors.forename: Jorma S A
authors.initials: JS
authors.lastname: Viikari
authors.forename: Olli T
authors.initials: OT
authors.lastname: Raitakari
authors.forename: Terho J
authors.initials: TJ
authors.lastname: Lehtimäki
mesh_terms: D000328:Adult; D000367:Age Factors; D001916:Brachial Artery / Q000502:physiology; D002340:Carotid Artery Diseases / Q000000981:diagnostic imaging / Q000235:genetics*; D015331:Cohort Studies; D017630:Connexins / Q000235:genetics*; D005260:Female; D005387:Finland; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D017539:Tunica Intima / Q000000981:diagnostic imaging; D017540:Tunica Media / Q000000981:diagnostic imaging; D014463:Ultrasonography; D014664:Vasodilation / Q000235:genetics* / Q000502:physiology; D000097006:Gap Junction alpha-4 Protein
chemical_list: D017630:Connexins; D000097006:Gap Junction alpha-4 Protein