title: Determination of simian immunodeficiency virus production by infected activated and resting cells.
abstract: OBJECTIVE
  To determine the relative amount of virus produced by activated and resting CD4+ T cells.
  
  
  METHODS
  The total quantity of virus produced by an activated cell relative to a resting cell in vivo was estimated from 'snap-shots' of virus production by infected cells at one time point.
  
  
  METHODS
  Bayesian statistical methods were used to determine a credible interval for the desired ratio.
  
  
  RESULTS
  The posterior mean of the ratio of virus produced by a typical activated cell to a typical resting cell is 0.82 to 4.28, depending on the half-lives of the resting infected cells. Simian immunodeficiency virus-infected resting cells could accordingly be responsible for 70 to 93% of peak virus production in the acute stage of infection.
  
  
  CONCLUSIONS
  Whereas in 'snap-shots' the infected resting cells apparently produce much less virus than infected activated CD4+ T cells, the coincidence of peak SIV production with predominant infection of resting cells along with longer half-lives for productively infected resting cells point to a major contribution to virus production in early infection.
authors.affiliation: Division of Biostatistics, School of Public Health, University of Minnesota, MN 55455-0378, USA. cavanr@biostat.umn.edu
authors.forename: Cavan
authors.initials: C
authors.lastname: Reilly
authors.forename: Steve
authors.initials: S
authors.lastname: Wietgrefe
authors.forename: Gerald
authors.initials: G
authors.lastname: Sedgewick
authors.forename: Ashley
authors.initials: A
authors.lastname: Haase
mesh_terms: D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000821:virology*; D008213:Lymphocyte Activation; D008253:Macaca mulatta; D008954:Models, Biological; D016097:Simian Acquired Immunodeficiency Syndrome / Q000276:immunology* / Q000821:virology; D015302:Simian Immunodeficiency Virus / Q000502:physiology*; D014771:Virion / Q000502:physiology; D014779:Virus Replication