title: TSP1 and MMP9 genetic variants in sporadic prostate cancer.
abstract: Angiogenesis plays an important role in the initiation and progression of many malignancies including prostate cancer (PCa). Therefore, genes implicated in angiogenic pathways could be susceptibility candidate genes for this malignancy. In this respect, we investigated the impact of functional genetic variants of TSP1 (N700S) and MMP9 (-1562 C/T) genes on the development and progression of PCa. This case-control study included 101 PCa patients and 106 healthy controls analyzed by polymerase chain reaction -restriction fragment length polymorphism assay. No association was observed between any of the TSP1 genotypes and PCa risk or severity; however, subjects carrying one copy of the MMP9 T allele exhibited threefold higher risk of developing PCa (OR = 2.86; P = 0.004). Regarding prognostic value, a significant association was found between the occurrence of the MMP9 T allele and the high-grade tumor (OR = 3.21; P = 0.004) and the advanced disease (OR = 2.47; P = 0.026). We also analyzed the effect of the combined genotypes on PCa risk. The patients with two high-risk genotypes exhibited 2.8-fold higher risk of developing PCa than those with only low-risk genotypes, but the association was not statistically significant. These findings suggest that MMP9 polymorphism is an independent risk factor of PCa development and aggressiveness.
authors.affiliation: Department of Molecular Immuno-Oncology, Faculty of Medicine, University of Monastir, Rue Avicenne 5019 Monastir, Tunisia. sana.sfar@medscape.com <sana.sfar@medscape.com>
authors.forename: Sana
authors.initials: S
authors.lastname: Sfar
authors.forename: Hamadi
authors.initials: H
authors.lastname: Saad
authors.forename: Faouzi
authors.initials: F
authors.lastname: Mosbah
authors.forename: Sallouha
authors.initials: S
authors.lastname: Gabbouj
authors.forename: Lotfi
authors.initials: L
authors.lastname: Chouchane
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics / Q000556:secondary; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D016022:Case-Control Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000235:genetics*; D008875:Middle Aged; D009367:Neoplasm Staging; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics*; D011467:Prostate / Q000378:metabolism / Q000473:pathology; D011471:Prostatic Neoplasms / Q000235:genetics*; D012307:Risk Factors; D019700:Thrombospondin 1 / Q000235:genetics*
chemical_list: D019700:Thrombospondin 1; D020780:Matrix Metalloproteinase 9