New alicyclic musks: the fourth generation of musk odorants.
Musk odorants are one of the most important classes of fragrances in perfumery because they impart sensuality to perfume-oil compositions. Among the three well-known classes of musks, a new and very exciting generation of musk odorants, the so-called alicyclic musks, was discovered recently, of which Helvetolide (2) and Romandolide (3) are the most popular representatives so far. To find new, structurally related alicyclic musks, we have synthesized a library of 114 unique alicyclic molecules with modified cyclohexyl moieties. The olfactory properties of all compounds were evaluated to identify the structural requirements to be met for a musk odorant.
Eh
Marcus
M
Symrise GmbH & Co. KG, Mühlenfeldstrasse 1, D-37603 Holzminden. marcus.eh@symrise.com
D005229:Fatty Acids, Monounsaturated / Q000138:chemical synthesis* / Q000737:chemistry / Q000302:isolation & purification; D006840:Hydrocarbons, Alicyclic / Q000138:chemical synthesis* / Q000737:chemistry / Q000302:isolation & purification; D009812:Odorants
D005229:Fatty Acids, Monounsaturated; D006840:Hydrocarbons, Alicyclic; C008563:musk