title: Maintaining hematopoietic stem cells in the vascular niche.
abstract: In this issue of Immunity, Sugiyama et al. (2006) provide evidence that most bone-marrow hematopoietic stem cells (HSCs) reside in vascular niches containing reticular cells that secrete CXCL12, a chemokine that promotes HSC maintenance.
authors.affiliation: Howard Hughes Medical Institute, Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, USA.
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Kiel
authors.forename: Sean J
authors.initials: SJ
authors.lastname: Morrison
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000098:blood supply / Q000648:ultrastructure*; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D006413:Hematopoietic System / Q000166:cytology*; D006801:Humans; D010006:Osteoblasts / Q000166:cytology