New photoproducts from irradiation of NADH with near-UV light.
Adenosine 5'-diphosphoribose (ADPR) and a second compound, which may be nicotinamide, are the newly discovered photoproducts resulting from irradiation of beta-nicotinamide adenine dinucleotide (beta-NADH) in the wavelength range of 300-400 nm under oxygen-poor conditions. Both products emerge there even exclusively, whereas, at higher oxygen concentrations, the oxidized form of nicotinamide adenine dinucleotide (NAD+) is additionally formed, although still as a minor product. The development of ADPR and NAD+ is clearly oxygen-dependent, while, for the formation of the second photoproduct, small quantities of oxygen appear to be sufficient.
Vitinius
Ute
U
Max-Planck-Institut für Bioanorganische Chemie (former MPI für Strahlenchemie), P.O. Box 101365, D-45413 Mülheim an der Ruhr. vitiniusu@yahoo.com
Schaffner
Kurt
K
Demuth
Martin
M
Heibel
Marija
M
Selbach
Horst
H
D009243:NAD / Q000032:analysis / Q000737:chemistry* / Q000528:radiation effects*; D010777:Photochemistry; D014466:Ultraviolet Rays
D009243:NAD