Innate resistance to Entamoeba histolytica in murine models.
Hamano et al. have recently reported that in murine models of amebiasis, innate resistance is associated with nonhemopoietic cells and depends on the activity of interleukin-10. This article raises the issue of the importance of predisposition to amebic colitis and discusses which host factors have a role in innate resistance to invasive disease. Resistance studies that elucidate the mechanisms involved in parasite clearance or parasite invasion are essential to understanding the incidence of amebiasis in humans.
Ivory
Catherine
C
Faculty of Medicine, Department of Microbiology and Infectious Diseases, University of Calgary Health Sciences Centre, 3330 Hospital Drive NW, Calgary, Alberta T2N 4N1, Canada.
Kammanadiminti
Srinivas
S
Chadee
Kris
K
D000818:Animals; D004195:Disease Models, Animal; D004198:Disease Susceptibility / Q000276:immunology; D004404:Dysentery, Amebic / Q000276:immunology* / Q000469:parasitology; D004748:Entamoeba histolytica / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology; D016753:Interleukin-10 / Q000276:immunology; D051379:Mice
D016753:Interleukin-10