title: Effects of amitryptiline administration on rat sera and brain beta-endorphins.
abstract: The aim of our study was to establish the influence of antidepressive drugs on serum and brain beta-endorphins in experimental animals. Experiment was performed on albino Wistar rats. Antidepressant amitryptiline was used, and for quantification of sera and brain beta-endorphins RIA technique. Our results showed difference between sera and brain beta-endorphins concentration in amitryptiline pretreated animals, vs. those in serum and brain of control group treated with 0.95% NaCl. This study shows that use of psychoactive drugs have influence on sera and brain beta-endorphins concentration. Beta-endorphins could be of great importance, used as markers for evaluation of antidepressant drug effects.
authors.affiliation: Institute for Physiology and Biochemistry, Faculty of Medicine, University of Sarajevo, Cekalusa 90, 71000 Sarajevo, Bosnia and Herzegovina.
authors.forename: Radivoj
authors.initials: R
authors.lastname: Jadrić
authors.forename: Sabaheta
authors.initials: S
authors.lastname: Hasić
authors.forename: Emina
authors.initials: E
authors.lastname: Kiseljaković
authors.forename: Jovan
authors.initials: J
authors.lastname: Radovanović
authors.forename: Emina
authors.initials: E
authors.lastname: Ićindić-Nakas
authors.forename: Mira
authors.initials: M
authors.lastname: Winterhalter-Jadrić
mesh_terms: D000639:Amitriptyline / Q000494:pharmacology*; D000818:Animals; D000929:Antidepressive Agents, Tricyclic / Q000494:pharmacology*; D001923:Brain Chemistry / Q000187:drug effects; D011333:Pro-Opiomelanocortin / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D001615:beta-Endorphin / Q000097:blood / Q000378:metabolism*
chemical_list: D000929:Antidepressive Agents, Tricyclic; D000639:Amitriptyline; D001615:beta-Endorphin; D011333:Pro-Opiomelanocortin