title: MRI intensity nonuniformity correction using simultaneously spatial and gray-level histogram information.
abstract: A novel approach for correcting intensity nonuniformity in magnetic resonance imaging (MRI) is presented. This approach is based on the simultaneous use of spatial and gray-level histogram information. Spatial information about intensity nonuniformity is obtained using cubic B-spline smoothing. Gray-level histogram information of the image corrupted by intensity nonuniformity is exploited from a frequential point of view. The proposed correction method is illustrated using both physical phantom and human brain images. The results are consistent with theoretical prediction, and demonstrate a new way of dealing with intensity nonuniformity problems. They are all the more significant as the ground truth on intensity nonuniformity is unknown in clinical images.
authors.affiliation: Division of Image Processing, Department of Radiology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands.
authors.forename: Julien
authors.initials: J
authors.lastname: Milles
authors.forename: Yue Min
authors.initials: YM
authors.lastname: Zhu
authors.forename: Gérard
authors.initials: G
authors.lastname: Gimenez
authors.forename: Charles R G
authors.initials: CR
authors.lastname: Guttmann
authors.forename: Isabelle E
authors.initials: IE
authors.lastname: Magnin
mesh_terms: D000465:Algorithms; D001921:Brain; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D008279:Magnetic Resonance Imaging