title: Chemical crosshairs on the central dogma.
abstract: As cellular machines and processes that regulate the flow of genomic information have come into sharper focus, a new level of chemical control has become possible. The scope of such chemical intervention extends from the mechanistic dissection of biochemical processes in living cells to the targeted control of gene networks and cell fate.
authors.affiliation: Genome Center of Wisconsin, Department of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA. ansari@biochem.wisc.edu
authors.forename: Aseem Z
authors.initials: AZ
authors.lastname: Ansari
mesh_terms: D000818:Animals; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D006801:Humans; D008024:Ligands; D008954:Models, Biological; D008958:Models, Molecular; D015394:Molecular Structure; D034622:RNA Interference / Q000187:drug effects / Q000502:physiology; D012319:RNA Polymerase II / Q000037:antagonists & inhibitors / Q000737:chemistry* / Q000378:metabolism / Q000502:physiology*; D014158:Transcription, Genetic
chemical_list: D004791:Enzyme Inhibitors; D008024:Ligands; D012319:RNA Polymerase II