Race-specific geography of prostate cancer incidence.
BACKGROUND
This study evaluated geographic distribution of race-specific prostate cancer incidence in Connecticut and Massachusetts. This cross-sectional analysis of census and cancer registry data included records of 29,040 Whites and 1,647 African Americans diagnosed with incident prostate cancer between 1994 and 1998. A spatial scan statistic was used to detect and test significance of the geographic variation in race-specific incidence rates within the two-state area.


RESULTS
Significant geographic variation in age-adjusted incidence rates among both White and African American men was observed, with little overlap noted between distributions. Identified locations reflected patterns of residential segregation and socio-economic conditions. Among Whites, places with higher than expected incidence had higher socioeconomic status than places with lower than expected incidence. No discernable relationship between social indicators and rate variation among African Americans was evident.


CONCLUSIONS
Differences in race-specific geographic distribution of prostate cancer incidence do not suggest a shared environmental etiology. Further study of genetic, behavioral and health care factors affecting the occurrence and/or reporting of the disease is warranted. This study highlights the need for race- and geographic-specific interventions to better control disease within at-risk communities and for on-going analysis into social and contextual factors that contribute to observed disparities between African Americans and Whites in the occurrence of cancer.
DeChello
Laurie M
LM
Department of Community Medicine & Health Care, University of Connecticut School of Medicine, 263 Farmington Ave, Farmington, CT 06030-6325, UK. dechello@nso.uchc.edu
Gregorio
David I
DI
Samociuk
Holly
H
D001741:Black or African American / Q000706:statistics & numerical data*; D003237:Connecticut / Q000453:epidemiology; D003430:Cross-Sectional Studies; D006801:Humans; D015994:Incidence; D008297:Male; D008404:Massachusetts / Q000453:epidemiology; D011471:Prostatic Neoplasms / Q000453:epidemiology* / Q000208:ethnology*; D012042:Registries / Q000706:statistics & numerical data; D019371:Topography, Medical; D044465:White People / Q000706:statistics & numerical data*