Synthesis of indenes by the transition metal-mediated carboannulation of alkynes.
The synthesis of highly substituted indenes has been achieved by three different transition metal-mediated methods. The first method involves the palladium-catalyzed carboannulation of internal alkynes. The second method utilizes a two-step approach, which involves first the palladium/copper-catalyzed cross-coupling of terminal alkynes with appropriately functionalized aryl halides, followed by copper-catalyzed intramolecular cyclization. The third method involves intermolecular palladium-catalyzed arylation of the arylalkynes formed in the first step of the second method.
Zhang
Daohua
D
Department of Chemistry, Iowa State University, Ames, Iowa 50011, USA.
Liu
Zhijian
Z
Yum
Eul K
EK
Larock
Richard C
RC
D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D003500:Cyclization; D007192:Indenes / Q000138:chemical synthesis* / Q000737:chemistry; D008314:Malonates / Q000737:chemistry; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*
D000480:Alkynes; D007192:Indenes; D008314:Malonates; D010165:Palladium; D003300:Copper; C030290:malonic acid