title: Evaluation of the acute adverse reaction of contrast medium with high and moderate iodine concentration in patients undergoing computed tomography.
abstract: OBJECTIVE
  The aim of this prospective study was to evaluate and compare acute adverse reactions between contrast medium containing moderate and high concentrations of iodine in patients undergoing computed tomography (CT).
  
  
  METHODS
  A total of 945 patients undergoing enhanced CT were randomly assigned to receive one of two doses of contrast medium. We then prospectively investigated the incidence of adverse reactions. Iopamidol was used as the contrast medium, with a high concentration of 370 mg I/ml and a moderate concentration of 300 mg I/ml. The frequency of adverse reactions, such as pain at the injection site and heat sensation, were determined.
  
  
  RESULTS
  Acute adverse reactions were observed in 2.4% (11/458) of the moderate-concentration group compared to 3.11% (15/482) of the high-concentration group; there was no significant difference in incidence between the two groups. Most adverse reactions were mild, and there was no significant difference in severity. One patient in the high-concentration group was seen to have a moderate adverse reaction. No correlation existed between the incidence of adverse reactions and patient characteristics such as sex, age, weight, flow amount, and flow rate. The incidence of pain was not significantly different between the two groups. In contrast, the incidence of heat sensation was significantly higher in the high-concentration group.
  
  
  CONCLUSIONS
  The incidence and severity of acute adverse reactions were not significantly different between the two groups, and there were no severe adverse reactions in either group.
authors.affiliation: Department of Radiology, School of Medicine, Toho University, 2-17-6 Ohashi, Meguro-ku, Tokyo 153-1251, Japan. nagamoto@oha.toho-u.ac.jp
authors.forename: Masashi
authors.initials: M
authors.lastname: Nagamoto
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Gomi
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Terada
authors.forename: Shigehiko
authors.initials: S
authors.lastname: Terada
authors.forename: Eiichi
authors.initials: E
authors.lastname: Kohda
mesh_terms: D003287:Contrast Media / Q000008:administration & dosage / Q000009:adverse effects* / Q000737:chemistry; D005260:Female; D006801:Humans; D007455:Iodine / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D014057:Tomography, X-Ray Computed / Q000009:adverse effects* / Q000379:methods
chemical_list: D003287:Contrast Media; D007455:Iodine