Selection for simple major surface protein 2 variants during Anaplasma marginale transmission to immunologically naïve animals.
Anaplasma marginale, a rickettsial pathogen, evades clearance in the animal host by antigenic variation. Under immune selection, A. marginale expresses complex major surface protein 2 mosaics, derived from multiple donor sequences. However, these mosaics have a selective advantage only in the presence of adaptive immunity and are rapidly replaced by simple variants following transmission.
Palmer
Guy H
GH
Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164-7040, USA. gpalmer@vetmed.wsu.edu
Futse
James E
JE
Leverich
Christina K
CK
Knowles
Donald P
DP
Rurangirwa
Fred R
FR
Brayton
Kelly A
KA
D042322:Anaplasma marginale / Q000235:genetics / Q000276:immunology*; D000712:Anaplasmosis / Q000276:immunology* / Q000382:microbiology / Q000635:transmission; D000818:Animals; D000942:Antigens, Bacterial / Q000235:genetics / Q000276:immunology*; D001425:Bacterial Outer Membrane Proteins / Q000235:genetics / Q000276:immunology*; D002417:Cattle; D003870:Dermacentor / Q000382:microbiology; D007113:Immunity, Innate; D008297:Male
D000942:Antigens, Bacterial; D001425:Bacterial Outer Membrane Proteins; C103348:msp2 protein, Anaplasma marginale