Antimicrobial activity of hydrophobic xanthones from Cudrania cochinchinensis against Bacillus subtilis and methicillin-resistant Staphylococcus aureus.
Ten xanthones with one or two isoprenoid groups and a prenylated benzophenone isolated from roots of Cudrania cochinchinensis (Moraceae) were tested for their antimicrobial activities against Bacillus subtilis and methicillin-resistant Staphylococcus aureus (MRSA). Among these compounds, gerontoxanthone H exhibited considerable antibacterial activity against B. subtilis (MIC = 1.56 microg/ml). Four xanthones, gerontoxanthone I, toxyloxanthone C, cudraxanthone S, and 1,3,7-trihydroxy-2-prenylxanthone, showed weak antibacterial activity against the bacterium (MICs = 3.13-6.25 microg/ml). These compounds also exhibited similar MIC values against methicillin-sensitive S. aureus, MRSAs, and Micrococcus luteus.
Fukai
Toshio
T
Department of Biophysical Chemistry, School of Pharmaceutical Sciences, Toho University, 2-2-1 Miyama, Funabashi, Chiba 274-8510, Japan. fukai@phar.toho-u.ac.jp
Oku
Yukio
Y
Hou
Ai-Jun
AJ
Yonekawa
Makiko
M
Terada
Sumio
S
D000890:Anti-Infective Agents / Q000302:isolation & purification / Q000494:pharmacology; D001412:Bacillus subtilis / Q000187:drug effects* / Q000254:growth & development; D004352:Drug Resistance, Microbial / Q000502:physiology; D016106:Methicillin Resistance / Q000187:drug effects* / Q000502:physiology; D008826:Microbial Sensitivity Tests; D029586:Moraceae; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology; D018517:Plant Roots; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000254:growth & development; D044004:Xanthones / Q000302:isolation & purification / Q000494:pharmacology*
D000890:Anti-Infective Agents; D010936:Plant Extracts; D044004:Xanthones