title: 2006: signaling breakthroughs of the year.
abstract: With nominations from leading scientists studying cell signaling, the STKE editors compile a list of the year's most important advances. Signaling breakthroughs included molecules and processes both outside cells and inside cells, from channels in the membrane to chromatin in the nucleus. The nominated research ranged from structural and functional revelations to approaches for the global analysis of signaling pathways. Receptors were highlighted with unexpected proteins functioning as receptors, as well as surprising functions for known receptors. This year also brought new insights into the impact of cell signaling on human physiology and disease.
authors.forename: Elizabeth M
authors.initials: EM
authors.lastname: Adler
authors.forename: Nancy R
authors.initials: NR
authors.lastname: Gough
authors.forename: L Bryan
authors.initials: LB
authors.lastname: Ray
mesh_terms: D000818:Animals; D015220:Calcium Channels / Q000502:physiology; D002923:Cilia / Q000502:physiology; D003315:Cornea / Q000502:physiology; D004059:Diffusion of Innovation; D006801:Humans; D008562:Membrane Glycoproteins / Q000502:physiology; D008565:Membrane Proteins / Q000502:physiology; D008954:Models, Biological; D000071740:ORAI1 Protein; D010766:Phosphorylation; D010940:Plant Proteins / Q000502:physiology; D011956:Receptors, Cell Surface / Q000502:physiology; D012106:Research; D015398:Signal Transduction / Q000502:physiology*; D000071737:Stromal Interaction Molecule 1; D013572:Synaptic Vesicles / Q000502:physiology
chemical_list: D015220:Calcium Channels; D008562:Membrane Glycoproteins; D008565:Membrane Proteins; D000071740:ORAI1 Protein; C510746:ORAI1 protein, human; D010940:Plant Proteins; D011956:Receptors, Cell Surface; C100757:Stim1 protein, mouse; D000071737:Stromal Interaction Molecule 1; C046131:auxin receptor, plant