title: A quality guarantee in acute coronary syndromes: the American College of Cardiology's Guidelines Applied in Practice program taken real-time.
abstract: BACKGROUND
  Wide variation exists in the management of acute coronary syndromes (ACSs), which includes an apparent underutilization of evidence-based therapies. We have previously demonstrated that application of the American College of Cardiology Guidelines Applied in Practice (GAP) tools can improve quality indicator rates and outcomes of patients hospitalized with ACS.
  
  
  OBJECTIVE
  To determine whether a real-time system for monitoring key quality-of-care indicators using GAP would improve both process indicators and outcomes beyond those of the initial implementation of GAP.
  
  
  METHODS
  Prospective patient identification, prospective chart coding, retrospective data abstraction.
  
  
  METHODS
  All patients with ACS admitted (N = 3189) to our institution between January 1, 1999, and December 2004; 2019 studied before real-time implementation from January 1, 1999, to June 30, 2002, and 1170 studied during real-time implementation from July 1, 2002, to December 31, 2004.
  
  
  METHODS
  The effect of real-time monitoring of key quality indicators on inhospital therapy and outcomes, and 6-month outcomes in patients admitted with ACS.
  
  
  RESULTS
  The real-time GAP implementation correlated with more frequent use of inhospital angiotensin-converting enzyme inhibitors (72.7% vs 63.7%, P < .0001), beta blockers (93.0% vs 89.7%, P = .0016), statins (81.2% vs 65.9%, P < .0001), antiplatelet agents (69.2% vs 22.5%, P < .0001), and glycoprotein IIb/IIIa inhibitors (35.5% vs 26.7%, P < .0001). There were fewer episodes of inhospital congestive heart failure (3.85% vs 8.77%, P < .0001) and major bleeding events (3.2% vs 7.9%, P < .0001) after the real-time system was adopted. Real-time GAP also resulted in higher discharge rates of aspirin (92.1% vs 86.5%, P < .0001), beta blockers (86.8% vs 79.1%, P < .0001), statins (81.2% vs 64.7%, P < .0001), and angiotensin-converting enzyme inhibitors (67.1% vs 55.5%, P < .0001). Real-time GAP implementation was associated with fewer rehospitalizations for heart disease (19.8% vs 25.2%, P = .0014), myocardial infarction (3.5% vs 5.4%, P = .0243), and combined death/cerebrovascular accident/myocardial infarction (9.5% vs 13.9%, P = .0009) during the first 6 months after discharge.
  
  
  CONCLUSIONS
  The institution of a formal system to review and "guarantee" key quality-of-care indicators real time in the hospital is associated with improved outcomes in patients admitted with ACS. The combination of American College of Cardiology's GAP program and its real-time implementation leads to higher use of evidence-based therapies and correspondingly better outcomes than those associated with the initial GAP implementation.
authors.affiliation: Division of Cardiovascular Medicine, Loyola University, Chicago, IL, USA.
authors.forename: Smit
authors.initials: S
authors.lastname: Vasaiwala
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Nolan
authors.forename: Vijay S
authors.initials: VS
authors.lastname: Ramanath
authors.forename: Jiaming
authors.initials: J
authors.lastname: Fang
authors.forename: Gwen
authors.initials: G
authors.lastname: Kearly
authors.forename: Sharon
authors.initials: S
authors.lastname: Van Riper
authors.forename: Eva
authors.initials: E
authors.lastname: Kline-Rogers
authors.forename: Richard
authors.initials: R
authors.lastname: Otten
authors.forename: Robert A
authors.initials: RA
authors.lastname: Cody
authors.forename: Kim A
authors.initials: KA
authors.lastname: Eagle
mesh_terms: D000789:Angina, Unstable / Q000628:therapy*; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D003199:Computer Systems; D019317:Evidence-Based Medicine / Q000706:statistics & numerical data; D005260:Female; D019983:Guideline Adherence / Q000458:organization & administration / Q000706:statistics & numerical data*; D006751:Hospital Information Systems; D006785:Hospitals, University / Q000592:standards; D006801:Humans; D008297:Male; D008824:Michigan; D008875:Middle Aged; D009203:Myocardial Infarction / Q000628:therapy*; D010043:Outcome and Process Assessment, Health Care / Q000458:organization & administration*; D017410:Practice Guidelines as Topic; D019984:Quality Indicators, Health Care; D013577:Syndrome; D014481:United States
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors