No association between Parkinson's disease and three polymorphisms in the eNOS, nNOS, and iNOS genes.
Nitric oxide synthases (NOS) and mitochondrial DNA-polymorphisms have been associated with the risk of developing Parkinson's disease (PD). In this report, we genotyped 450 PD-patients and 200 controls for three polymorphisms in the endothelial, inducible and neuronal NOS-genes, and for the T4336C and A10398G mitochondrial DNA-polymorphisms. None of the eNOS (intron 4 VNTR), iNOS (exon 22 A/G), or nNOS (exon 29T/C) were significantly associated with PD. Mitochondrial 4336C increased the PD-risk among women (OR=6.13), while the 10398G had a protective effect (OR=0.52). We did not find significantly interactions between the NOS and mitochondrial polymorphisms in the risk for PD in our population.
Huerta
Cecilia
C
Genética Molecular-Instituto de Investigación Nefrológica, Hospital Central de Asturias, Servicio de Salud del Principado de Asturias, Spain.
Sánchez-Ferrero
Elena
E
Coto
Eliecer
E
Blázquez
Marta
M
Ribacoba
René
R
Guisasola
Luis M
LM
Salvador
Carlos
C
Alvarez
Victoria
V
D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D052250:Nitric Oxide Synthase Type III / Q000235:genetics*; D010300:Parkinson Disease / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*
D052250:Nitric Oxide Synthase Type III