title: Analogues of 2-crotonyloxymethyl-(4R,5R,6R)-4,5,6-trihydroxycyclohex-2-enone (COTC) with anti-tumor properties.
abstract: The syntheses of three novel analogues of the naturally occurring cytotoxic agent COTC are described and the results of bioassays of the target compounds against two lung cancer cell lines are presented.
authors.affiliation: School of Chemistry, University of Manchester, Oxford Road, Manchester M13 9PL, UK.
authors.forename: Claire L
authors.initials: CL
authors.lastname: Arthurs
authors.forename: Natasha S
authors.initials: NS
authors.lastname: Wind
authors.forename: Roger C
authors.initials: RC
authors.lastname: Whitehead
authors.forename: Ian J
authors.initials: IJ
authors.lastname: Stratford
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D003512:Cyclohexanones / Q000138:chemical synthesis* / Q000494:pharmacology; D015195:Drug Design; D005978:Glutathione / Q000378:metabolism; D006801:Humans; D007202:Indicators and Reagents; D008175:Lung Neoplasms / Q000188:drug therapy
chemical_list: D000970:Antineoplastic Agents; D003512:Cyclohexanones; D007202:Indicators and Reagents; C011202:2-crotonyloxymethyl-(4R,5R,6R)-4,5,6-trihydroxycyclohex- 2-enone; D005978:Glutathione