title: Nanoengineered polymer capsules: tools for detection, controlled delivery, and site-specific manipulation.
abstract: We present the concept of multifunctional nanoengineered polymer capsules and outline their applications as new drug delivery systems or supramolecular toolboxes containing, for example, enzymes capable of converting nontoxic prodrugs into toxic drugs at a designated location. Such functionalized nanocontainers offer a wide range of applications including enzymatic catalysis, controlled release, and directed drug delivery in medicine due to their multifunctionality. The unique advantage of capsules in comparison to other systems is that they can be functionalized or loaded simultaneously with the above-mentioned components, thus permitting multifunctional processes in single cells.
authors.affiliation: Max Planck Institute of Colloids and Interface, 14424 Potsdam/Golm, Germany, Fax. gleb@mpikg-golm.mpg.de
authors.forename: Gleb B
authors.initials: GB
authors.lastname: Sukhorukov
authors.forename: Andrey L
authors.initials: AL
authors.lastname: Rogach
authors.forename: Bernd
authors.initials: B
authors.lastname: Zebli
authors.forename: Tim
authors.initials: T
authors.lastname: Liedl
authors.forename: Andre G
authors.initials: AG
authors.lastname: Skirtach
authors.forename: Karen
authors.initials: K
authors.lastname: Köhler
authors.forename: Alexei A
authors.initials: AA
authors.lastname: Antipov
authors.forename: Nikolai
authors.initials: N
authors.lastname: Gaponik
authors.forename: Andrei S
authors.initials: AS
authors.lastname: Susha
authors.forename: Mathias
authors.initials: M
authors.lastname: Winterhalter
authors.forename: Wolfgang J
authors.initials: WJ
authors.lastname: Parak
mesh_terms: D000818:Animals; D001943:Breast Neoplasms / Q000628:therapy; D002214:Capsules; D002384:Catalysis; D016503:Drug Delivery Systems; D004798:Enzymes / Q000737:chemistry; D005456:Fluorescent Dyes / Q000494:pharmacology; D006801:Humans; D008280:Magnetics; D008856:Microscopy, Fluorescence; D053769:Nanocapsules / Q000008:administration & dosage* / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*; D036103:Nanotechnology / Q000379:methods; D011108:Polymers / Q000737:chemistry*; D045663:Quantum Dots
chemical_list: D002214:Capsules; D004798:Enzymes; D005456:Fluorescent Dyes; D053769:Nanocapsules; D011108:Polymers