title: FoxO4 is the main forkhead transcriptional factor localized in the gastrointestinal tracts of pigs.
abstract: Forkhead box (Fox) proteins play critical roles in the regulation of differentiation, proliferation, immunity and aging of cells. Most studies on Fox proteins are limited to cultured cells and rodent. The aim of the current study is to detect by immunohistrochemistry whether FoxO1, FoxO3a and FoxO4 proteins are localized in the stomach and intestine of the pig. The results showed that FoxO4 exists in the mucosa in all parts of the stomach and intestine; FoxO3a exists mainly in the lamina propria and muscularis of some parts. However, FoxO1 is not detectable in all parts of the stomach and intestine. Collectively, the results of the present study indicate that there exists a distinct expression pattern of Fox proteins, and that FoxO4 is a primary forkhead transcriptional factor localized in the gastrointestinal tracts of the pig.
authors.affiliation: College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China.
authors.forename: Zhen-qi
authors.initials: ZQ
authors.lastname: Zhou
authors.forename: Tian
authors.initials: T
authors.lastname: Wang
authors.forename: Ling-mei
authors.initials: LM
authors.lastname: Pan
authors.forename: Rui-hua
authors.initials: RH
authors.lastname: Huang
authors.forename: Fang-xiong
authors.initials: FX
authors.lastname: Shi
mesh_terms: D000818:Animals; D005260:Female; D051858:Forkhead Transcription Factors / Q000378:metabolism*; D041981:Gastrointestinal Tract / Q000378:metabolism*; D007150:Immunohistochemistry; D008297:Male; D034421:Sus scrofa / Q000378:metabolism*; D014018:Tissue Distribution
chemical_list: D051858:Forkhead Transcription Factors