title: [Mandibular Langerhans cell histiocytosis].
abstract: BACKGROUND
  Langerhan's cell histiocytosis is defined as an abnormal proliferation of Langerhans cells in various organs and tissues (bone, skin, lymph nodes...). Among facial locations, mandibular involvement is the most frequent and occurs in young people less than 20 years. The aim of this report is to review the characteristic features of this disease, the current means of diagnosis and treatment through two case reports.
  
  
  METHODS
  Two male patients aged 10 and 55 years respectively presented with single mandibular location of Langerhans cell histiocytosis. The diagnosis was confirmed by histological examination of the biopsy specimen. The first patient underwent surgical resection of the tumor. No recurrence was observed. In the second patient, the postoperative course was marked by the appearance of an inflammatory phenomenon in the adjacent skin and mucosa, successfully treated by intralesional corticosteroid therapy.
  
  
  CONCLUSIONS
  Langerhan's cell histiocytosis is a rare disease. The mandibular location has variable clinical expressions which can vary from dental mobility to tumor development in the gingiva. The radiological appearance is also variable; histological proof is required for diagnosis. Treatment depends on the number and locations of the lesions. In case of a single location, the treatment options may vary from a "wait and see" attitude to a non aggressive surgery, with a possible local corticosteroid therapy or radiothe-rapy. For multiples locations, chemotherapy is indicated.
authors.affiliation: Service de Chirurgie Maxillo-faciale, EPS Habib Bourguiba, Sfax, Tunisie. morcheddhouib@yahoo.fr
authors.forename: M
authors.initials: M
authors.lastname: Dhouib
authors.forename: N
authors.initials: N
authors.lastname: Triki
authors.forename: F
authors.initials: F
authors.lastname: Karray
authors.forename: A
authors.initials: A
authors.lastname: Khabir
authors.forename: T
authors.initials: T
authors.lastname: Boudaoura
authors.forename: M
authors.initials: M
authors.lastname: Abdelmoula
mesh_terms: D002648:Child; D006646:Histiocytosis, Langerhans-Cell / Q000473:pathology*; D006801:Humans; D008297:Male; D008336:Mandibular Diseases / Q000473:pathology*; D008875:Middle Aged