title: [A case of advanced hepatocellular carcinoma with lung metastases and cirrhosis that responded to combination chemotherapy with interferon-alpha and 5-fluorouracil].
abstract: The prognosis for patients with hepatocellular carcinoma (HCC) with progressive liver cirrhosis or extrahepatic metastases remains dismal. We report a case of HCC with liver cirrhosis and lung metastases who had been treated successfully by combination chemotherapy of 5-fluorouracil (5-FU) and interferon-alpha (IFN-alpha). A 67-year-old male with a history of hepatitis C, liver cirrhosis and HCC was hospitalized because of cough and dyspnea. Computed tomography (CT) of chest revealed multiple lung metastases. Systemic combination chemotherapy with 5-FU and IFN-alpha was begun, and lung metastases disappeared after one course of treatment. He died of liver failure one year later, but no recurrence of lung metastases was seen. Although systemic combination chemotherapy of 5-FU and IFN-alpha induced the bone marrow suppression, it was effective for lung metastases and palliates symptoms and signs in our case of HCC.
authors.affiliation: Dept. of Medical Oncology, Misawa City Hospital.
authors.forename: Kohei
authors.initials: K
authors.lastname: Shitara
authors.forename: Masaki
authors.initials: M
authors.lastname: Munakata
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Kudo
authors.forename: Osamu
authors.initials: O
authors.lastname: Muto
authors.forename: Ritsuko
authors.initials: R
authors.lastname: Okada
authors.forename: Sumako
authors.initials: S
authors.lastname: Mitobe
authors.forename: Yuh
authors.initials: Y
authors.lastname: Sakata
authors.forename: Makoto
authors.initials: M
authors.lastname: Kondo
authors.forename: Eiji
authors.initials: E
authors.lastname: Ishii
authors.forename: Koji
authors.initials: K
authors.lastname: Yabu
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy* / Q000556:secondary; D004334:Drug Administration Schedule; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D016898:Interferon-alpha / Q000008:administration & dosage; D008103:Liver Cirrhosis / Q000150:complications*; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000473:pathology; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000556:secondary*; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D012074:Remission Induction
chemical_list: D016898:Interferon-alpha; D005472:Fluorouracil