[Research on relationship of syndrome type and parameters of hemorheology and platelet activation in patients with acute gout arthritis of dampness-heat blockage type and stasis-heat accumulate type].
OBJECTIVE
To study the relationship between syndrome type and the parameters of hemorrheology and platelet activation in patients with acute gout arthritis of dampness-heat blockage (DHB) type and stasis-heat accumulation (SHA) type.


METHODS
Forty patients with acute gouty arthritis were divided into 2 groups according to TCM syndrome differentiation, the DHB group (n=24) and the SHA group (n=16), and 20 healthy people were taken as the control group. Hemorrheological parameters, platelet activating factor (PAC-1) and P-selection (CD62p) in them were detected.


RESULTS
Plasma viscosity, outcome of erythrocyte sedimentation and K value of its equation, levels of PAC-1 and CD62p were higher, erythrocyte electrophoresis index was significantly lower in gout patients of both types than those in the control group (all P < 0.01), and the levels of PAC-1 and CD62p in the SHA group were higher than those in the DHB group (P < 0.05).


CONCLUSIONS
DHB type and SHA syndrome type of acute gout arthritis are correlated with parameters of hemorrheology and platelet activation, and the different levels of these pameters showed in the two types, may be the internal factors for their genesis.
Shao
Pei
P
Department of TCM, Shenzhen Hospital, Peking University, Guang-dong. shaopeisz@126.com
Huang
Xing-tao
XT
Zjang
Fan
F
D000208:Acute Disease; D000328:Adult; D000368:Aged; D001168:Arthritis / Q000097:blood / Q000473:pathology* / Q000503:physiopathology; D003937:Diagnosis, Differential; D005260:Female; D006073:Gout / Q000097:blood / Q000473:pathology* / Q000503:physiopathology; D018056:Hemorheology; D006801:Humans; D008297:Male; D008516:Medicine, Chinese Traditional; D008875:Middle Aged; D019007:P-Selectin / Q000097:blood; D010972:Platelet Activating Factor / Q000378:metabolism; D015539:Platelet Activation; D013577:Syndrome
D019007:P-Selectin; D010972:Platelet Activating Factor