Highly-methylated colorectal cancers show poorly-differentiated phenotype.
The combined methylation status of pl6, pl4, HLTF, SOCS-1, CDH13, RUNX3 and CHFR was examined in 58 resected primary colorectal cancers using methylation-specific PCR, and the methylation status was correlated with the clinicopathological features of the affected patients. A significant difference in histology (p = 0.0041) was observed when the number of methylated genes of poorly-differentiated colorectal cancers was compared to that of other differentiated ones. Poorly-differentiated colorectal cancers preferentially exhibited gene methylation.
Hibi
Kenji
K
Department of Surgery, Showa University Fujigaoka Hospital, 1-30 Fujigaoka, Aoba-ku, Yokohama 227-8501, Japan. kenjih-ngy@umin.ac.jp
Nakao
Akimasa
A
D002454:Cell Differentiation; D015179:Colorectal Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D019175:DNA Methylation; D006801:Humans; D010641:Phenotype; D016133:Polymerase Chain Reaction