title: [High relationship between ciprofloxacin use and prevalence of ESBL Klebsiella pneumoniae].
abstract: BACKGROUND
  To assess the relationship between ciprofloxacin use and the prevalence of extended spectrum betalactamases (ESBL) Klebsiella pneumoniae.
  
  
  METHODS
  Semestral mean values regarding use of antibiotic and prevalence of ESBL Kp were compared during 9 semesters using linear regression and coefficient of correlation.
  
  
  RESULTS
  The only statistically significant correlation was ciprofloxacin use and ESBL(+) K. pneumoniae prevalence, with a coefficient of correlation of 0.86 and p = 0.0027 using linear regression.
  
  
  CONCLUSIONS
  Ciprofloxacin use must be taking into account when considering infection control programs due to high prevalence rates of ESBL(+) K. pneumoniae in the hospital setting.
authors.affiliation: Departamento de Estadística, Hospital Español, Rosario, Argentina. jbermejo@uolsinectis.com.ar
authors.forename: Joaquín
authors.initials: J
authors.lastname: Bermejo
authors.forename: Blanca
authors.initials: B
authors.lastname: Bencomo
authors.forename: Nora
authors.initials: N
authors.lastname: Arnesi
authors.forename: Patricia
authors.initials: P
authors.lastname: Lesnaberes
authors.forename: Noemí
authors.initials: N
authors.lastname: Borda
authors.forename: Rodolfo
authors.initials: R
authors.lastname: Notario
mesh_terms: D000900:Anti-Bacterial Agents / Q000009:adverse effects / Q000627:therapeutic use*; D002511:Cephalosporins / Q000009:adverse effects / Q000627:therapeutic use*; D002939:Ciprofloxacin / Q000009:adverse effects / Q000627:therapeutic use*; D003430:Cross-Sectional Studies; D024881:Drug Resistance, Bacterial; D006801:Humans; D007710:Klebsiella Infections / Q000188:drug therapy / Q000382:microbiology*; D007711:Klebsiella pneumoniae / Q000187:drug effects* / Q000201:enzymology; D008826:Microbial Sensitivity Tests; D012307:Risk Factors; D001618:beta-Lactamases / Q000096:biosynthesis* / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D002939:Ciprofloxacin; D001618:beta-Lactamases