Channeling to the nucleus.
L-type voltage-gated calcium channels (LTCs) may control neuronal gene expression by increasing nuclear Ca(2+) levels or regulating Ca(2+)/calmodulin-dependent transcription factors. In the November 3 issue of Cell, Gomez-Ospina et al. demonstrate another signaling mechanism, in which a C-terminal fragment of LTC translocates to the nucleus in a calcium-dependent manner and directly regulates transcription.
Chung
Hee Jung
HJ
Department of Physiology, Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, California 94143, USA.
Jan
Lily Y
LY
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D020746:Calcium Channels, L-Type / Q000502:physiology*; D020013:Calcium Signaling / Q000502:physiology*; D002467:Cell Nucleus / Q000502:physiology*; D015870:Gene Expression / Q000502:physiology*; D009474:Neurons / Q000166:cytology / Q000502:physiology
D020746:Calcium Channels, L-Type; D002118:Calcium