title: The FXIIIVal34Leu, common and risk factors of venous thrombosis in early middle-age Costa Rican patients.
abstract: In this study, eight common polymorphisms associated with venous thrombosis (VT) and thrombophilia factors were analyzed in a Costa Rican case-control study. With the use of polymerase chain reaction (PCR) methods the polymorphisms were detected in 120 patients and 133 controls (mean age <40 years old). It was concluded that a high level of fibrinogen, antiphospholipid antibodies, family history, and the genotype 34LeuLeu of FXIII OR 0.42 (0.20-0.89) showed a significant effect on the risk of VT. Associations between the risk of VT and genetic polymorphisms have been established. Some of these polymorphisms are highly prevalent in Caucasians, but there is a significant geographic variation in their prevalence among different populations. The results of this study support the protective effect of FXIII Val34Leu polymorphism in VT. These findings are consistent with previous reports that included other populations.
authors.affiliation: Institute of Human Genetics, Ernst Moritz Arndt University, Greifswald, Germany. lizbeth.salazar@gmail.com
authors.forename: Lizbeth
authors.initials: L
authors.lastname: Salazar-Sánchez
authors.forename: Maria Paz
authors.initials: MP
authors.lastname: Leon
authors.forename: Mayra
authors.initials: M
authors.lastname: Cartin
authors.forename: Gudrun
authors.initials: G
authors.lastname: Schuster
authors.forename: Karin
authors.initials: K
authors.lastname: Wulff
authors.forename: Winnie
authors.initials: W
authors.lastname: Schröder
authors.forename: Gerardo
authors.initials: G
authors.lastname: Jiménez-Arce
authors.forename: Ronald
authors.initials: R
authors.lastname: Chacon
authors.forename: Falko H
authors.initials: FH
authors.lastname: Herrmann
mesh_terms: D000328:Adult; D019943:Amino Acid Substitution; D017152:Antibodies, Antiphospholipid / Q000097:blood; D016022:Case-Control Studies; D003364:Costa Rica; D005176:Factor XIII / Q000235:genetics*; D005260:Female; D005340:Fibrinogen / Q000378:metabolism; D005787:Gene Frequency; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D012307:Risk Factors; D020246:Venous Thrombosis / Q000097:blood / Q000235:genetics* / Q000473:pathology
chemical_list: D017152:Antibodies, Antiphospholipid; D005340:Fibrinogen; D005176:Factor XIII