title: Apparent mineralocorticoid excess manifested in an elderly patient with hypothyroidism.
abstract: The syndrome of apparent mineralocorticoid excess (AME) is characterized by persistent hypertension and hypokalemia, which is caused by impaired inactivation of cortisol (F) to cortisone (E). The thyroid hormone has been known to influence the F to E conversion leading to efficacious inactivation of F into E. However, there have been no reports regarding the clinical manifestation of secondary AME due to hypothyroidism. Here we report an elderly patient who manifested AME, showing persistent hypertension with hypokalemia induced by primary hypothyroidism. Maintenance of euthyroid conditions ameliorated the concurrent AME and restored adrenal secretion of aldosterone after the recovery of the F to E shuttle. This case report would broaden our clinical recognition regarding acquired AME in relation to thyroid dysfunction.
authors.affiliation: Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Okayama City 700-8558, Japan.
authors.forename: Kenichi
authors.initials: K
authors.lastname: Inagaki
authors.forename: Fumio
authors.initials: F
authors.lastname: Otsuka
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Otani
authors.forename: Chikage
authors.initials: C
authors.lastname: Sato
authors.forename: Tomoko
authors.initials: T
authors.lastname: Miyoshi
authors.forename: Toshio
authors.initials: T
authors.lastname: Ogura
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Makino
mesh_terms: D000369:Aged, 80 and over; D000450:Aldosterone / Q000097:blood; D005260:Female; D006801:Humans; D006973:Hypertension / Q000209:etiology; D007008:Hypokalemia / Q000209:etiology; D007037:Hypothyroidism / Q000150:complications* / Q000188:drug therapy; D043204:Mineralocorticoid Excess Syndrome, Apparent / Q000188:drug therapy / Q000209:etiology*
chemical_list: D000450:Aldosterone