[Biochemical markers of bone formation in hemodialysis and after allotransplantation of cadaveric kidney].
OBJECTIVE
To ascertain informative value of estimation of bone forming markers in patients on chronic hemodyalisis (CHD) and recipients of cadaveric kidney (CK).


METHODS
Parathyroid hormone (PTH), beta-crosslaps (CTX), osteocalcin (OC), amino-terminal procollagen propeptide 1 (PINP), bone alkaline phosphatase (BAP), bone mineral density (BMD) were determined in 152 patients on CHD (89 males and 63 females aged 49 +/- 13 years) and 195 CK recipients (106 males and 89 females aged 42 +/- 12 years) 30 +/- 38 months after kidney transplantation.


RESULTS
PTH, CTX and BAP determination specifies skeletal disease (secondary hyperparathyroidism or adynamic bone disease) in CHD patients. In patients with CK recipients osteoporosis differed from osteopenia by higher levels of PTH, CTX, OC in the absence of any differences in BAP, PINP. All bone forming markers were lower than CTX showing suppression of bone forming. Bone fractures in CK recipients' anamnesis were associated with OC and BAP decrease in men and low border of normal OC in women. Determination of bone formation and resorption markers in patients on CHD and CK recipients is of great clinical importance.
Ermakova
I P
IP
Pronchenko
I A
IA
Buzulina
V P
VP
Nikonova
T Iu
TIu
Borisova
A V
AV
D015415:Biomarkers; D015519:Bone Density; D001851:Bone Diseases, Metabolic / Q000453:epidemiology* / Q000209:etiology / Q000503:physiopathology; D001862:Bone Resorption / Q000453:epidemiology / Q000209:etiology / Q000503:physiopathology; D002102:Cadaver; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000453:epidemiology / Q000503:physiopathology* / Q000628:therapy*; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D010012:Osteogenesis / Q000502:physiology*; D010024:Osteoporosis / Q000453:epidemiology* / Q000209:etiology / Q000503:physiopathology; D011183:Postoperative Complications; D006435:Renal Dialysis / Q000009:adverse effects*
D015415:Biomarkers