Prolonged decrease in stress reactivity caused by dehydroepiandrosterone sulfate.
In male rats exposed to repeated stress, the decrease in stress reactivity produced by subcutaneous injection of dehydroepiandrosterone sulfate (recorded by the decrease in stress-induced concentrations of corticosterone and adrenocorticotropic hormone in blood plasma) was observed 1-6 days postinjection and involved central regulatory mechanisms.
Obut
T A
TA
Institute of Physiology, Siberian Division, Russian Academy of Medical Sciences, Novosibirsk. t.a.obut@iph.ma.nsc.ru
Ovsyukova
M V
MV
Cherkasova
O P
OP
D000324:Adrenocorticotropic Hormone / Q000097:blood; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D003345:Corticosterone / Q000097:blood; D019314:Dehydroepiandrosterone Sulfate / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D051381:Rats; D013312:Stress, Physiological / Q000188:drug therapy* / Q000503:physiopathology*; D013997:Time Factors
D019314:Dehydroepiandrosterone Sulfate; D000324:Adrenocorticotropic Hormone; D003345:Corticosterone