G protein coupled receptor structure and activation.
G protein coupled receptors (GPCRs) are remarkably versatile signaling molecules. The members of this large family of membrane proteins are activated by a spectrum of structurally diverse ligands, and have been shown to modulate the activity of different signaling pathways in a ligand specific manner. In this manuscript I will review what is known about the structure and mechanism of activation of GPCRs focusing primarily on two model systems, rhodopsin and the beta(2) adrenoceptor.
Kobilka
Brian K
BK
Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA. kobilka@stanford.edu
D058666:Adrenergic beta-2 Receptor Agonists; D000818:Animals; D006801:Humans; D011487:Protein Conformation; D018343:Receptors, Adrenergic, beta-2 / Q000737:chemistry; D043562:Receptors, G-Protein-Coupled / Q000819:agonists* / Q000737:chemistry*; D012243:Rhodopsin / Q000819:agonists / Q000737:chemistry
D058666:Adrenergic beta-2 Receptor Agonists; D018343:Receptors, Adrenergic, beta-2; D043562:Receptors, G-Protein-Coupled; D012243:Rhodopsin