Advances in the diagnosis and management of von Willebrand disease.
von Willebrand disease (VWD), the most common inherited bleeding disorder, is caused by a quantitative (type 1 and 3) or qualitative (type 2) defect of von Willebrand factor (VWF). In this review, the present knowledge regarding the diagnosis and the management of VWD is briefly analyzed.
Franchini
Massimo
M
Servizio di Immunoematologia e Trasfusione, Azienda Ospedaliera di Verona, Verona, Italy. mfranchini@univr.it
D000941:Antigens; D001704:Biopolymers; D019090:Case Management; D003894:Deamino Arginine Vasopressin / Q000627:therapeutic use; D019468:Disease Management; D005169:Factor VIII / Q000008:administration & dosage / Q000627:therapeutic use; D005799:Genes, Dominant; D005808:Genes, Recessive; D006470:Hemorrhage / Q000209:etiology / Q000517:prevention & control; D006489:Hemostatic Techniques; D006801:Humans; D010641:Phenotype; D010976:Platelet Count; D021122:Protein Subunits; D012189:Retrospective Studies; D014842:von Willebrand Diseases / Q000145:classification / Q000175:diagnosis* / Q000235:genetics / Q000628:therapy*; D014841:von Willebrand Factor / Q000235:genetics
D000941:Antigens; D001704:Biopolymers; D021122:Protein Subunits; C029417:Von Willebrand antigen; D014841:von Willebrand Factor; C078147:F8 protein, human; D005169:Factor VIII; D003894:Deamino Arginine Vasopressin