[Molecular logic of alcohol and taste].
Ethanol, a main constituent of every alcohol beverage, has long been calling our attention to its gustatory effect. Recent molecular dynamics studies have suggested that ethanol as well as other tastants in foods, when taken in the oral cavity, gives rise to a taste signal which is expressed via reception at taste cells in the taste bud, intracellular signal transduction in collaboration with G proteins and effecters, and signal transmission to synapsed taste neurons, and/or simultaneous reception at and signal transduction in somatosensory neurons. The taste of ethanol and its acceptability are then recognized and judged at the higher center, with generation of various physiological phenomena in the body. We have tried to make an all-inclusive DNA microarray analysis, demonstrating that when a rat tongue is stimulated with a drop of aqueous ethanol in vivo, several particular genes are specifically up- or down-regulated in trigeminal ganglions. These initial gene expression changes at peripheral neurocytes might in whole or in part trigger some of the ethanol-associated gustatory and bodily response. The importance of defining a related molecular logic is emphasized to understand academic and industrial significances of this unique food constituent, ethanol.
Matsumoto
Ichiro
I
Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan.
Abe
Keiko
K
Arai
Soichi
S
D000434:Alcoholic Beverages; D000818:Animals; D053843:DNA Mismatch Repair; D000431:Ethanol; D050485:GABA Plasma Membrane Transport Proteins / Q000502:physiology; D019204:GTP-Binding Proteins / Q000502:physiology; D005786:Gene Expression Regulation; D006801:Humans; D010812:Physical Stimulation; D051381:Rats; D015398:Signal Transduction; D009435:Synaptic Transmission; D050916:TRPV Cation Channels / Q000502:physiology; D013649:Taste / Q000235:genetics* / Q000502:physiology*; D013650:Taste Buds / Q000166:cytology / Q000502:physiology*; D012668:Trigeminal Ganglion / Q000502:physiology
D050485:GABA Plasma Membrane Transport Proteins; D050916:TRPV Cation Channels; C494484:TRPV1 receptor; D000431:Ethanol; D019204:GTP-Binding Proteins