title: Acetyl- and butyrylcholinesterase activities decrease in human colon adenocarcinoma.
abstract: Apart from the hydrolysis of acetylcholine (ACh), acetyl- (AChE) and butyrylcholinesterase (BChE), through noncatalytic mechanisms, intervene in hematopoiesis, morphogenesis, and neurogenesis (Layer and Willbold, 1995; Soreq and Seidman, 2001). Cholinesterase (ChE) molecules occur as globular (G1, G2, and G4) and asymmetric (A4, A8, and A12) forms (Legay, 2000; Massoulié, 2002). The G species might display amphiphilic (GA) or hydrophilic (GH) properties (Perrier et al., 2002). The involvement of ChEs in tumorigenesis is supported by the measurement of ChE activity in tumors (García-Ayllón et al., 2001; Ruiz-Espejo et al., 2003), the amplification of ChE genes in leukemias and ovarian tumors, and the relationship between the expression of AChE and the aggressiveness of astrocytomas(Perry et al., 2002). This research was undertaken to determine whether ChE activity is altered in gut carcinomas.
authors.affiliation: Departamento de Bioquímica y Biología Molecular-A, Universidad de Murcia, 30071 Murcia, Spain.
authors.forename: María Fernanda
authors.initials: MF
authors.lastname: Montenegro
authors.forename: Francisco
authors.initials: F
authors.lastname: Ruiz-Espejo
authors.forename: Francisco Javier
authors.initials: FJ
authors.lastname: Campoy
authors.forename: Encarnación
authors.initials: E
authors.lastname: Muñoz-Delgado
authors.forename: María Páez
authors.initials: MP
authors.lastname: de la Cadena
authors.forename: Juan
authors.initials: J
authors.lastname: Cabezas-Herrera
authors.forename: Cecilio J
authors.initials: CJ
authors.lastname: Vidal
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism*; D000230:Adenocarcinoma / Q000201:enzymology*; D002091:Butyrylcholinesterase / Q000378:metabolism*; D003106:Colon / Q000201:enzymology; D003110:Colonic Neoplasms / Q000201:enzymology*; D006801:Humans; D007700:Kinetics; D012007:Rectum / Q000201:enzymology; D012016:Reference Values
chemical_list: D000110:Acetylcholinesterase; D002091:Butyrylcholinesterase