title: Impairment of several immune functions in anxious women.
abstract: OBJECTIVE
  Controversial results concerning immune function changes taking place in anxious subjects have been obtained. The aim of the present work was to study immune function in a group of anxious women.
  
  
  METHODS
  Thirty-three anxious and 33 nonanxious age-matched women were included. Anxiety levels were determined by the Beck Anxiety Inventory. Peripheral blood samples were collected, and several leukocyte functions, as well as cytokine release, were studied. Plasma cortisol levels and total antioxidant capacity were also evaluated.
  
  
  RESULTS
  The results showed diminished chemotaxis, phagocytosis, lymphoproliferation in response to phytohemagglutinin mitogen, natural killer activity, and interleukin-2 release, and augmented superoxide anion levels and tumor necrosis factor-alpha release in anxious women. Plasma cortisol was increased, while total antioxidant capacity was lowered in those subjects.
  
  
  CONCLUSIONS
  The findings suggest impaired immune function and cytokine release in anxious women. This might be related to increased cortisol secretion, which would lead to oxidative stress reflected in lowered plasma total antioxidant capacity.
authors.affiliation: Department of Physiology (Animal Physiology II), Faculty of Biology, Complutense University of Madrid, Madrid, Spain.
authors.forename: Lorena
authors.initials: L
authors.lastname: Arranz
authors.forename: Noelia
authors.initials: N
authors.lastname: Guayerbas
authors.forename: Mónica
authors.initials: M
authors.lastname: De la Fuente
mesh_terms: D000328:Adult; D001008:Anxiety Disorders / Q000276:immunology* / Q000523:psychology; D002634:Chemotaxis, Leukocyte / Q000276:immunology; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D007111:Immunity, Cellular / Q000276:immunology*; D007121:Immunocompetence / Q000276:immunology*; D007376:Interleukin-2 / Q000097:blood; D007694:Killer Cells, Natural / Q000276:immunology; D008213:Lymphocyte Activation / Q000276:immunology; D008875:Middle Aged; D009504:Neutrophils / Q000276:immunology; D010555:Personality Inventory; D010587:Phagocytosis / Q000276:immunology; D013481:Superoxides / Q000097:blood; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D007376:Interleukin-2; D014409:Tumor Necrosis Factor-alpha; D013481:Superoxides; D006854:Hydrocortisone