title: A new Bacillus pasteurii urease inhibitor from Euphorbia decipiens.
abstract: Inhibition of Bacillus pasteurii urease enzyme by 3,7,15-tri-O-acetyl-5-O-nicotinoyl-13,14-dihydroxymyrsinol (1), a diterpene ester with a myrsinol-type skeleton, isolated from Euphorbia decipiens Boiss. and Buhse, was un-competitive consistent with the molecular docking results. The Ki value was 117.40 +/- 0.7 microM.
authors.affiliation: Dr. Panjwani Center for Molecular Medicine and Drug Research, HEJ Research Institute of Chemistry, University of Karachi, Karachi-75270, Pakistan.
authors.forename: Muhammad Arif
authors.initials: MA
authors.lastname: Lodhi
authors.forename: Javid
authors.initials: J
authors.lastname: Hussain
authors.forename: Muhammad Athar
authors.initials: MA
authors.lastname: Abbasi
authors.forename: Amir Reza
authors.initials: AR
authors.lastname: Jassbi
authors.forename: Muhammad Iqbal
authors.initials: MI
authors.lastname: Choudhary
authors.forename: Viqar Uddin
authors.initials: VU
authors.lastname: Ahmad
mesh_terms: D001407:Bacillus / Q000201:enzymology*; D001665:Binding Sites; D003198:Computer Simulation; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D028481:Euphorbia / Q000737:chemistry*; D007700:Kinetics; D008958:Models, Molecular; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D017434:Protein Structure, Tertiary; D014510:Urease / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000378:metabolism
chemical_list: D004224:Diterpenes; D004791:Enzyme Inhibitors; D010936:Plant Extracts; D014510:Urease