Pharmacological inhibition of TRalpha1 receptor potentiates the thyroxine effect on body weight reduction in rats: potential therapeutic implications in controlling body weight.
It has been previously reported that thyroid hormone receptor alpha1 (TRalpha1) is involved in the regulation of food intake and heart rhythm. Herein, we show that pharmacological inhibition of TRalpha1 by dronedarone, an amiodarone like compound (shown to antagonize thyroid hormone binding to TRalpha1), prevented the thyroid hormone induced increase in food intake and heart rate acceleration in rats. This resulted in a marked reduction in body weight. It is likely that thyroid analogs may prove potential therapeutic agents for controlling body weight.
Pantos
C
C
Mourouzis
I
I
Paizis
I
I
Malliopoulou
V
V
Xinaris
Ch
Ch
Moraitis
P
P
Cokkinos
A D
AD
Cokkinos
D V
DV
D000638:Amiodarone / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D000077764:Dronedarone; D004357:Drug Synergism; D004435:Eating / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D037021:Thyroid Hormone Receptors alpha / Q000037:antagonists & inhibitors*; D013974:Thyroxine / Q000494:pharmacology*; D015431:Weight Loss / Q000187:drug effects*
D037021:Thyroid Hormone Receptors alpha; D000077764:Dronedarone; D000638:Amiodarone; D013974:Thyroxine