Biomarkers of oxidative stress in schizophrenic and control subjects.
Increasing evidence indicates that oxidative injury exists in schizophrenia. Although it may not be the main cause, oxidative damage has been suggested to contribute to the pathophysiology and may account for deteriorating course and poor outcome in schizophrenia. A human study was undertaken, therefore, to investigate possible differences in biomarkers of DNA, lipid and protein oxidation in schizophrenic (n=16) and control subjects (n=17). Plasma vitamin C levels were also compared in both groups. Cellular DNA damage and plasma protein carbonyl levels were increased in the schizophrenic group compared to control subjects but not significantly. However, DNA damage in lymphocytes from the male schizophrenic group was significantly higher than the female group. Biomarkers of lipid peroxidation and plasma vitamin C levels also revealed no significant difference between the two groups under investigation, although a significant elevation in plasma vitamin C was observed in the female control group when compared to the male groups.
Young
J
J
School of Pharmacy, The Robert Gordon University, Schoolhill, Aberdeen, UK.
McKinney
S B
SB
Ross
B M
BM
Wahle
K W J
KW
Boyle
S P
SP
D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use; D001205:Ascorbic Acid / Q000097:blood; D015415:Biomarkers / Q000032:analysis / Q000378:metabolism*; D016022:Case-Control Studies; D002478:Cells, Cultured; D015925:Cryopreservation; D004249:DNA Damage; D005260:Female; D006801:Humans; D006861:Hydrogen Peroxide / Q000494:pharmacology; D015227:Lipid Peroxidation / Q000187:drug effects; D008214:Lymphocytes / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D050050:Protein Carbonylation; D011618:Psychotic Disorders / Q000188:drug therapy / Q000378:metabolism*
D014150:Antipsychotic Agents; D015415:Biomarkers; D006861:Hydrogen Peroxide; D001205:Ascorbic Acid