title: Benzophenanthridine alkaloids from Zanthoxylum nitidum (Roxb.) DC, and their analgesic and anti-inflammatory activities.
abstract: Seven benzophenanthridine alkaloids, 1-7, were isolated from the roots of Zanthoxylum nitidum. Among them, two novel alkaloids, named (R)-8-[(R)-1-hydroxyethyl]dihydrochelerythrine (1) and 8-methoxynorchelerythrine (2), were structurally identified as new compounds on the basis of the spectroscopic analysis. Bioactivity evaluation showed that nitidine (3), dihydrochelerythrine (4), oxyavicine (5), 8-methoxychelerythrine (6), and 8-hydroxydihydrochelerythrine (7) exhibit comparable analgesic and anti-inflammatory effects as hydrocortisone.
authors.affiliation: Department of Phytochemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, P.R. China.
authors.forename: Jiang
authors.initials: J
authors.lastname: Hu
authors.forename: Wei-Dong
authors.initials: WD
authors.lastname: Zhang
authors.forename: Run-Hui
authors.initials: RH
authors.lastname: Liu
authors.forename: Chuan
authors.initials: C
authors.lastname: Zhang
authors.forename: Yun-Heng
authors.initials: YH
authors.lastname: Shen
authors.forename: Hui-Liang
authors.initials: HL
authors.lastname: Li
authors.forename: Ming-Jin
authors.initials: MJ
authors.lastname: Liang
authors.forename: Xi-Ke
authors.initials: XK
authors.lastname: Xu
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use; D053119:Benzophenanthridines / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use; D004487:Edema / Q000188:drug therapy; D008297:Male; D051379:Mice; D015394:Molecular Structure; D010146:Pain / Q000188:drug therapy; D018517:Plant Roots / Q000737:chemistry; D013329:Structure-Activity Relationship; D032106:Zanthoxylum / Q000737:chemistry*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D053119:Benzophenanthridines