Expression of interleukin-17 in human colorectal cancer.
The proinflammatory cytokine IL-17 plays a potential role in T-cell mediated angiogenesis and promotes tumourigenicity of human cervical cancer. The objective of this study was to determine whether IL-17 protein level is altered in colorectal tumours (n=74) compared with paired normal mucosa and in plasma from patients (n=61) with colorectal cancer (CRC) compared with a healthy group (n=78). Analyses by ELISA showed that IL-17 protein was undetectable in 48.6% of the patients with cancer, as well as corresponding normal tissue which may in part reflect an individual difference. No significant difference was observed regarding IL-17 protein levels between cancer and matched normal tissue or in plasma between patients and the healthy group. Immunohistochemistry (n=20) revealed heterogenous immunoreactivity in 65% of the cases. The results of this study suggest that IL-17 plays a minor or partial role in CRC.
Wägsäter
Dick
D
Atherosclerosis Research Unit, King Gustav V Research Institute, Department of Medicine, Karolinska Institute, SE-171 76 Stockholm.
Löfgren
Sture
S
Hugander
Anders
A
Dimberg
Jan
J
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015179:Colorectal Neoplasms / Q000097:blood / Q000378:metabolism* / Q000473:pathology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D020381:Interleukin-17 / Q000097:blood / Q000378:metabolism*; D008297:Male; D008875:Middle Aged
D020381:Interleukin-17