title: Structure elucidation and antioxidant activity of (-)-isosilandrin isolated from Silybum marianum L.
abstract: A regioisomer of the known flavanolignan (-)-silandrin (3a), named (-)-isosilandrin (8a), was isolated from the fruits of a white-flowered variant of Silybum marianum L. populated in Hungary. Its structure was established both by spectroscopic methods and total synthesis, and its absolute configuration was determined by means of circular dichroism. This compound showed stronger inhibitory activity on the superoxide anion (O2*-) release by human polymorphonuclear leukocytes (PMNL) than (+)-silybin (1a,b).
authors.affiliation: Research Institute for Medicinal Plants, P.O. Box 11, H-2011 Budakalász.
authors.forename: Zsuzsanna
authors.initials: Z
authors.lastname: Samu
authors.forename: Szabolcs
authors.initials: S
authors.lastname: Nyiredy
authors.forename: Eszter
authors.initials: E
authors.lastname: Baitz-Gács
authors.forename: Zsuzsa
authors.initials: Z
authors.lastname: Varga
authors.forename: Tibor
authors.initials: T
authors.lastname: Kurtán
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Dinya
authors.forename: Sándor
authors.initials: S
authors.lastname: Antus
mesh_terms: D000975:Antioxidants / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D005638:Fruit; D006801:Humans; D007962:Leukocytes / Q000187:drug effects / Q000378:metabolism; D020944:Silybum marianum; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D012838:Silymarin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D000975:Antioxidants; D010936:Plant Extracts; D012838:Silymarin; C075820:isosilybin