title: Novel antibacterial diterpenoids from Larix chinensis Beissn.
abstract: Two novel labdane-type diterpenoids, butanedioic acid mono[(13S)-13-hydroxylabda-8(17),14-dien-19-yl] ester (1) and butanedioic acid bis[(13S)-13-hydroxylabda-8(17),14-dien-19-yl] ester (2), along with the eleven known diterpenoids 3-13 and three other known compounds, were isolated from the bark of Larix chinensis. Their structures were elucidated both spectroscopically and chemically. The major diterpenoids 1-9, 11, and 13, as well as the very abundant phenolic compound 16, were subjected to antibacterial and cytotoxic bioassays. Compounds 7 and 9 showed remarkable in vitro inhibition of Staphylococcus aureus and S. epidermidis (MIC = 37-73 microM).
authors.affiliation: State Key Laboratory of Drug Research, Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai, 201203, PR China.
authors.forename: Jun-Juan
authors.initials: JJ
authors.lastname: Xue
authors.forename: Cheng-Qi
authors.initials: CQ
authors.lastname: Fan
authors.forename: Lei
authors.initials: L
authors.lastname: Dong
authors.forename: Sheng-Ping
authors.initials: SP
authors.lastname: Yang
authors.forename: Jian-Min
authors.initials: JM
authors.lastname: Yue
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification*; D015507:Drugs, Investigational / Q000737:chemistry / Q000302:isolation & purification; D028221:Larix; D008826:Microbial Sensitivity Tests / Q000706:statistics & numerical data; D024301:Plant Bark; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification
chemical_list: D000900:Anti-Bacterial Agents; D004224:Diterpenes; D015507:Drugs, Investigational; D010936:Plant Extracts