Antifungal constituents from the Chinese moss Homalia trichomanoides.
Bioautographic assay on TLC plates was adopted to guide the fractionation of the Et2O extract of Homalia trichomanoides (Hedw.) B. S. G., which led to the isolation of the novel p-terphenyl derivative trichomanin (= 4,4''-dihydroxy-1,1':4',1''-terphenyl-2',3',5',6'-tetrayl tetrakis(phenylacetate); 1), together with five known compounds: 3alpha-methoxyserrat-14-en-21beta-ol (2), 3beta-methoxyserrat-14-en-21beta-ol (3), 3beta-methoxyserrat-14-en-21-one (4), atranorin (5), and methyl 2,4-dihydroxy-3,6-dimethylbenzoate (6). Their structures were determined on the basis of spectral data (1D- and 2D-NMR, MS), X-ray crystallographic analysis, and chemical transformation. Compounds 3, 5, and 6 exhibited antifungal activity against Candida albicans, with minimum inhibitory doses (MID) of 2.0, 2.0, and 0.6 microg, respectively.
Wang
Xiao-ning
XN
School of Pharmaceutical Sciences, Shandong University, No. 44 West Wenhua Road, Jinan 250012, PR China.
Yu
Wen-tao
WT
Lou
Hong-xiang
HX
D000935:Antifungal Agents / Q000737:chemistry* / Q000494:pharmacology*; D044002:Bryophyta / Q000737:chemistry*; D002176:Candida albicans / Q000187:drug effects; D002681:China; D008958:Models, Molecular; D015394:Molecular Structure
D000935:Antifungal Agents