Cultivation-independent analysis of changes in bacterial vaginosis flora following metronidazole treatment.
PCR was used to survey bacterial vaginosis flora before and after metronidazole treatment. The species composition for pretreatment patients was variable. Lactobacillus iners was prominent in all patients posttreatment. Atopobium vaginae concentrations were highest for patients who failed or responded incompletely to treatment and lowest for patients who were cured.
Ferris
Michael J
MJ
Department of Pediatrics, Louisiana State University Health Sciences Center, New, Orleans, Louisiana 70112, USA. mferris@chnola-research.org
Norori
Johana
J
Zozaya-Hinchliffe
Marcela
M
Martin
David H
DH
D039903:Actinobacteria / Q000235:genetics / Q000254:growth & development / Q000302:isolation & purification*; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D004269:DNA, Bacterial / Q000032:analysis; D005260:Female; D006801:Humans; D007778:Lactobacillus / Q000235:genetics / Q000254:growth & development / Q000302:isolation & purification*; D008795:Metronidazole / Q000627:therapeutic use*; D016133:Polymerase Chain Reaction / Q000379:methods*; D016896:Treatment Outcome; D016585:Vaginosis, Bacterial / Q000188:drug therapy* / Q000382:microbiology*
D000890:Anti-Infective Agents; D004269:DNA, Bacterial; D008795:Metronidazole