title: Antioxidants and hormones as antiaging therapies: high hopes, disappointing results.
abstract: No single agent has been shown to truly reverse aging or increase longevity in humans. This article reviews the evidence of efficacy (or lack thereof) for two types of agents touted as antiaging therapies: antioxidants (vitamin E, vitamin C, and carotenoids) and hormones (growth hormone, testosterone, dehydroepiandrosterone, and vitamin D).
authors.affiliation: Department of internal Medicine, Division of Geriatric Medicine, St. Louis University School of Medicine, MO, USA.
authors.forename: Nabil S
authors.initials: NS
authors.lastname: Kamel
authors.forename: Julie
authors.initials: J
authors.lastname: Gammack
authors.forename: Oscar
authors.initials: O
authors.lastname: Cepeda
authors.forename: Joseph H
authors.initials: JH
authors.lastname: Flaherty
mesh_terms: D000375:Aging / Q000187:drug effects*; D000975:Antioxidants / Q000627:therapeutic use*; D002318:Cardiovascular Diseases / Q000517:prevention & control; D002561:Cerebrovascular Disorders / Q000517:prevention & control; D003071:Cognition / Q000187:drug effects; D003687:Dehydroepiandrosterone / Q000627:therapeutic use; D019587:Dietary Supplements; D013006:Growth Hormone / Q000627:therapeutic use; D006728:Hormones / Q000627:therapeutic use*; D006801:Humans; D008055:Lipids; D008136:Longevity / Q000187:drug effects*; D013739:Testosterone / Q000627:therapeutic use; D014815:Vitamins / Q000627:therapeutic use*
chemical_list: D000975:Antioxidants; D006728:Hormones; D008055:Lipids; D014815:Vitamins; D013739:Testosterone; D003687:Dehydroepiandrosterone; D013006:Growth Hormone