[Comparison of retrograde amnesia changes within different injury levels of cerebral concussion in rats].
OBJECTIVE
To investigate the retrograde amnesia changes within different injury levels of cerebral concussion in rats.


METHODS
A metallic pendulum striker device of brain injury was deployed to duplicate CC models of different injury levels within Sprague-Dawley (S-D) rats. The investigated animals were divided into two groups according to classification standard, that is, Pure Cerebral Concussion (PCC) group and Complicated Cerebral Concussion (CCC) group. One control group was used, and each group included 8 animals. The retrograde amnesia of each group was assessed by Morris Water Maze (MWM) Test from 3 days preinjury to 7 days postconcussion.


RESULTS
Compared with the control group, the retrograde amnesia was detected within 3 days in PCC group, and 5 days in CCC group after injury. At the same time, the two groups both manifested space recognition deficit.


CONCLUSIONS
The retrograde amnesia existed in both pure cerebral concussion group and complicated cerebral concussion. Furthermore, the lasting time of retrograde amnesia in animals correlates to the injury level of brain concussion.
Liu
Jian-Xing
JX
Department of Forensic Medicine, Kunming Medical College, Kunming, China.
Yu
Jian-Yun
JY
Xu
Bing-Ying
BY
Guo
Li-Ping
LP
Lan
Guang-Ming
GM
Zhao
Xu-Dong
XD
Feng
Zhong-Tang
ZT
D000648:Amnesia, Retrograde / Q000209:etiology / Q000523:psychology*; D000818:Animals; D001924:Brain Concussion / Q000150:complications / Q000473:pathology / Q000523:psychology*; D004195:Disease Models, Animal; D005260:Female; D015601:Injury Severity Score; D008297:Male; D018782:Maze Learning; D008568:Memory; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors