[Evaluation of the four simple methods in the diagnosis of diabetic peripheral neuropathy].
OBJECTIVE
To evaluate the efficacy of neuropathy symptom score/neuropathy disability score (NSS/NDS), Michigan Neuropathy Screening Instrument (MNSI), vibration perception threshold (VPT) and 24010 g monofilament examination in the diagnosis of diabetic peripheral neuropathy (DPN).


METHODS
240 patients with type 2 diabetes underwent the 4 simple tests: NSS/NDS, MNSI, VPT, and 10 g monofilament examination and nerve conduction velocity (NCV) examination. Using the results of NCV as golden criteria, the sensitivity, specificity, positive and negative predictive values, accuracy and kappa values of these tests were analyzed.


RESULTS
The sensitivity, specificity, accuracy, and kappa value of MNSI score over 2 were 78.15%, 88.43%, 83.33%, and 0.67 respectively. The validity could be ranked in the following order with respect to the diagnosis of DPN: MNSI > VPT > NSS/NDS > 10 g monofilament examination.


CONCLUSIONS
MNSI is a rapid, simple and reliable test for screening DPN in both diabetes clinics and epidemiological surveys.
Jia
Wei-ping
WP
Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Department of Endocrinology & Metabolism of Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai 200233, China.
Shen
Qin
Q
Bao
Yu-qian
YQ
Lu
Jun-xi
JX
Li
Ming
M
Xiang
Kun-san
KS
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D003929:Diabetic Neuropathies / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009431:Neural Conduction; D009460:Neurologic Examination / Q000379:methods; D010523:Peripheral Nervous System Diseases / Q000175:diagnosis / Q000503:physiopathology; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013497:Sural Nerve / Q000503:physiopathology