[Neuroprotective effect of quercetin during experimental brain ischemia].
The neuroprotective action by water-soluble form of quercetin was examined in gerbils after transient forebrain ischemia. The animals were exposed to 7 min of bilateral common carotid artery occlusion. Hippocampal CA 1 area was examined 7 days after ischemia-reperfusion. The average density of CA1 pyramidal neurons and GFAP-positive glial cells were counted in sham operated group, in ischemic group and in the groups treated with water-soluble form of quercetin. It was shown that quercetin revealed protective effect by decreasing of delayed neuronal death and reducing reactive astrogliosis after ischemia-reperfusion.
Kovalenko
T M
TM
Osadchenko
I O
IO
Tsupykov
O M
OM
Pivneva
T A
TA
Shalamaĭ
A S
AS
Moĭbenko
O O
OO
Skybo
H H
HH
D000818:Animals; D001253:Astrocytes / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D002545:Brain Ischemia / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control; D004195:Disease Models, Animal; D005849:Gerbillinae; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D007150:Immunohistochemistry; D008297:Male; D009474:Neurons / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D018696:Neuroprotective Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D017966:Pyramidal Cells / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D011794:Quercetin / Q000008:administration & dosage / Q000627:therapeutic use*
D005904:Glial Fibrillary Acidic Protein; D018696:Neuroprotective Agents; D011794:Quercetin