Production of dihydroisocoumarins in Fusarium verticillioides by swapping ketosynthase domain of the fungal iterative polyketide synthase Fum1p with that of lovastatin diketide synthase.
Zhu
Xiangcheng
X
Department of Chemistry, University of Nebraska--Lincoln, Lincoln, Nebraska 68588, USA.
Yu
Fengan
F
Li
Xing-Cong
XC
Du
Liangcheng
L
D005656:Fungal Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D005670:Fusarium / Q000201:enzymology* / Q000235:genetics; D049934:Isocoumarins / Q000378:metabolism*; D008148:Lovastatin / Q000378:metabolism; D048630:Polyketide Synthases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D015202:Protein Engineering; D017434:Protein Structure, Tertiary / Q000235:genetics; D011993:Recombinant Fusion Proteins / Q000235:genetics / Q000378:metabolism*
D005656:Fungal Proteins; D049934:Isocoumarins; D011993:Recombinant Fusion Proteins; D048630:Polyketide Synthases; D008148:Lovastatin