title: GC-MS quantification of suspected volatile allergens in fragrances. 2. Data treatment strategies and method performances.
abstract: The performances of the GC-MS determination of suspected allergens in fragrance concentrates have been investigated. The limit of quantification was experimentally determined (10 mg/L), and the variability was investigated for three different data treatment strategies: (1) two columns and three quantification ions; (2) two columns and one quantification ion; and (3) one column and three quantification ions. The first strategy best minimizes the risk of determination bias due to coelutions. This risk was evaluated by calculating the probability of coeluting a suspected allergen with perfume constituents exhibiting ions in common. For hydroxycitronellal, when using a two-column strategy, this may statistically occur more than once every 36 analyses for one ion or once every 144 analyses for three ions in common.
authors.affiliation: Takasago, 23-25 Avenue De la Mare, F-95310 Saint Ouen l'Aumône, France.
authors.forename: Maud
authors.initials: M
authors.lastname: Bassereau
authors.forename: Alain
authors.initials: A
authors.lastname: Chaintreau
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Duperrex
authors.forename: Daniel
authors.initials: D
authors.lastname: Joulain
authors.forename: Hans
authors.initials: H
authors.lastname: Leijs
authors.forename: Gerd
authors.initials: G
authors.lastname: Loesing
authors.forename: Neil
authors.initials: N
authors.lastname: Owen
authors.forename: Alan
authors.initials: A
authors.lastname: Sherlock
authors.forename: Christine
authors.initials: C
authors.lastname: Schippa
authors.forename: Pierre-Jean
authors.initials: PJ
authors.lastname: Thorel
authors.forename: Matthias
authors.initials: M
authors.lastname: Vey
mesh_terms: D000485:Allergens / Q000032:analysis*; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods*; D010476:Perfume / Q000737:chemistry*; D011786:Quality Control; D015203:Reproducibility of Results; D023422:Skin Irritancy Tests; D014835:Volatilization
chemical_list: D000485:Allergens; D010476:Perfume