title: [From CANUSA to ADEMEX: do we need a new paradigm for definition of peritoneal dialysis adequacy?].
abstract: Peritoneal dialysis doses were prescribed out of empirical criteria up to the mid-Ninety Then, the observational CANUSA study and the experimental ADEMEX study helped to define adequacy criteria according to urea kinetics model. This review analyzes the limits of a definition of adequacy grounded exclusively on urea kinetics, as well as the need for new parameters of adequacy. The evidence is presented fostering the hypothesis that the control of extra-cellular fluid excess and of other cardiovascular risk factors may now be considered a new target for adequacy.
authors.affiliation: Unità Operativa di Nefrologia Dialisi e Trapianto Renale e CNR-IBIM, Istituto di Biomedicina, Azienda Ospedaliera, Reggio Calabria. eniag@libero.it
authors.forename: G
authors.initials: G
authors.lastname: Enia
mesh_terms: D002318:Cardiovascular Diseases / Q000517:prevention & control*; D002986:Clinical Trials as Topic; D045604:Extracellular Fluid; D006801:Humans; D007676:Kidney Failure, Chronic / Q000401:mortality / Q000628:therapy*; D010530:Peritoneal Dialysis / Q000592:standards*; D010537:Peritoneum / Q000378:metabolism; D011379:Prognosis; D016032:Randomized Controlled Trials as Topic; D012307:Risk Factors; D016019:Survival Analysis; D016896:Treatment Outcome; D014508:Urea / Q000378:metabolism*; D014511:Uremia / Q000517:prevention & control
chemical_list: D014508:Urea