[Advances in cardiovascular medicine through molecular imaging].
We will witness a change of paradigm in cardiovascular imaging, which is empowered by advances in imaging technology, biochemistry, molecular biology and nanotechnology. Instead of simply following the physical distribution of established contrast agents, we now have the opportunity to noninvasively image biological processes such as enzyme activity, interaction with cell surface markers, gene expression and cell migration. These advancements open up new avenues in basic cardiovascular research and will greatly speed up the pace of discovery. Patient management will profit as well: cardiovascular molecular imaging will strengthen personlized and prophylactic medicine through timely and precise diagnostics. In our review we describe selected molecular imaging strategies in atherosclerosis, myocardial ischemia and healing.
Nahrendorf
M
M
Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Rm. 5406, 149 13th St., Charlestown, MA 02129, USA. MNahrendorf@partners.org
Weissleder
R
R
D000818:Animals; D002318:Cardiovascular Diseases / Q000175:diagnosis* / Q000503:physiopathology*; D015510:Clinical Medicine / Q000639:trends*; D003952:Diagnostic Imaging / Q000639:trends*; D006801:Humans; D008967:Molecular Biology / Q000639:trends*; D015336:Molecular Probe Techniques / Q000639:trends*