title: Flow Focusing: a versatile technology to produce size-controlled and specific-morphology microparticles.
abstract: The Flow Focusing platform is especially advantageous for micro- and nanoparticle production. This versatile technique is amenable to designing the size, surface treatment and internal topology of the particles; mechanical stresses are minimal-an optimal feature for the manipulation of delicate substances. Multiplexing and high-rate production are readily implemented. Adaptive operational design can lead, in one single step, to finely tuned microcapsules encasing different products within a targeted morphology. This achievement is of great significance for most microcapsule applications in the biosciences (for example, drug delivery, cell encapsulation, and the production of bead arrays).
authors.affiliation: Dpto. Mecánica de Fluidos, Escuela Superior de Ingenieros, Universidad de Sevilla, Camino de los Descubrimientos s/n, 41092 Sevilla, Spain.
authors.forename: Lucía
authors.initials: L
authors.lastname: Martín-Banderas
authors.forename: María
authors.initials: M
authors.lastname: Flores-Mosquera
authors.forename: Pascual
authors.initials: P
authors.lastname: Riesco-Chueca
authors.forename: Alfonso
authors.initials: A
authors.lastname: Rodríguez-Gil
authors.forename: Angel
authors.initials: A
authors.lastname: Cebolla
authors.forename: Sebastián
authors.initials: S
authors.lastname: Chávez
authors.forename: Alfonso M
authors.initials: AM
authors.lastname: Gañán-Calvo
mesh_terms: D004337:Drug Carriers; D004339:Drug Compounding; D016503:Drug Delivery Systems; D005456:Fluorescent Dyes / Q000494:pharmacology; D019344:Lactic Acid / Q000737:chemistry; D044085:Microfluidics; D008855:Microscopy, Electron, Scanning; D008863:Microspheres; D053758:Nanoparticles / Q000737:chemistry; D036103:Nanotechnology / Q000191:economics / Q000295:instrumentation / Q000379:methods*; D010316:Particle Size; D011100:Polyglycolic Acid / Q000737:chemistry; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011108:Polymers / Q000737:chemistry; D011137:Polystyrenes / Q000737:chemistry; D012997:Solvents
chemical_list: D004337:Drug Carriers; D005456:Fluorescent Dyes; D011108:Polymers; D011137:Polystyrenes; D012997:Solvents; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid