title: Feasibility and utility of a lung donor score: correlation with early post-transplant outcomes.
abstract: BACKGROUND
  A lung donor score may provide a numerical value of overall donor lung "quality" to allow comparison among different organizations and research protocols. This study aims to develop a simple scoring system and investigate its applicability on predicting donor selection and early post-lung-transplant (LTx) outcomes.
  
  
  METHODS
  Data of all donors referred to our institution in 2001 were initially analyzed to create a LTx donor score. Five domains, age, smoking history, chest X-ray, secretions, and arterial blood gas results, were included. A larger cohort of transplant recipients (years 2002 to 2005) was analyzed to validate the score against early post-LTx outcomes.
  
  
  RESULTS
  In the initial 2001 cohort, 36 of 87 (41%) donors were used for 41 LTx (used group) and 51 (59%) were declined for medical (lung-exclusion group, n = 31) and general (general-exclusion group, n = 20) reasons. The median donor scores in the used, general-exclusion, and lung-exclusion groups were 2.0, 2.0, and 10.0, respectively (p < 0.0001). In multivariate analysis of the validation cohort, the donor score in bilateral LTx was significantly associated with post-transplant ratio of arterial oxygen tension and inspired oxygen fraction (coefficient = -16.19, p = 0.002), primary graft dysfunction grade (coefficient = 0.21, p < 0.0001), and intubation hours (coefficient = 0.05, p = 0.04); however, a significant association was not seen in single LTx.
  
  
  CONCLUSIONS
  A proposed simple donor scoring system, based on five major donor variables available at the time of donor selection, may be useful for data comparison between specific centers, quality control, evaluative research, and clinical decision making in donor selection and management in LTx.
authors.affiliation: Department of Allergy, Immunology, and Respiratory Medicine, Lung Transplant Unit, The Alfred Hospital and Monash University, Melbourne, Australia.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Oto
authors.forename: Bronwyn J
authors.initials: BJ
authors.lastname: Levvey
authors.forename: Helen
authors.initials: H
authors.lastname: Whitford
authors.forename: Anne P
authors.initials: AP
authors.lastname: Griffiths
authors.forename: Tom
authors.initials: T
authors.lastname: Kotsimbos
authors.forename: Trevor J
authors.initials: TJ
authors.lastname: Williams
authors.forename: Gregory I
authors.initials: GI
authors.lastname: Snell
mesh_terms: D000328:Adult; D000368:Aged; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007362:Intensive Care Units; D007902:Length of Stay; D016040:Lung Transplantation / Q000401:mortality; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D010100:Oxygen / Q000097:blood; D012044:Regression Analysis; D014019:Tissue Donors; D016896:Treatment Outcome
chemical_list: D010100:Oxygen