title: Production of non-standard PET radionuclides and the application of radiopharmaceuticals labeled with these nuclides.
abstract: The field of positron emission tomography (PET) has expanded dramatically over recent years. In spite of this expansion the large majority of clinical studies are carried out utilizing one radiopharmaceutical-2-fluoro-2-deoxyglucose. Many research groups are developing novel radiopharmaceuticals. A major emphasis is on other agents labeled with 18F. Several other positron emitting radionuclides can be prepared in high yields in small biomedical cyclotrons. Some of these have half-lives that make delivery significantly easier than the delivery of 18F compounds. These radionuclides include: 64Cu (half life 12.7 h), 76Br (half life 16.2 h), 86Y (half life 14.74 h) and 124I (half life 4.2 days). The method of production of these and other 'non-standard' PET radionuclides will be discussed and the method of labeling radiopharmaceuticals with these radionuclides described. Several of these radiopharmaceuticals have been studied in animal models as well and a limited number translated to the human situation.
authors.affiliation: Department of Radiology, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA. WelchM@mir.wustl.edu
authors.forename: M J
authors.initials: MJ
authors.lastname: Welch
authors.forename: R
authors.initials: R
authors.lastname: Laforest
authors.forename: J S
authors.initials: JS
authors.lastname: Lewis
mesh_terms: D000818:Animals; D006207:Half-Life; D006801:Humans; D015335:Molecular Probes / Q000138:chemical synthesis / Q000737:chemistry; D049268:Positron-Emission Tomography / Q000379:methods*; D011868:Radioisotopes / Q000737:chemistry; D019275:Radiopharmaceuticals / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D015335:Molecular Probes; D011868:Radioisotopes; D019275:Radiopharmaceuticals