title: Malignant spinal cord compression in cancer patients may be mimicked by a primary spinal cord tumour.
abstract: Although it is quite rare, second primary neoplasms in cancer patients may present with the signs and symptoms of malignant spinal cord compression. Primary spinal cord tumours in the cancer patients may be deceptive and considered as the recurrent first cancer. Therefore, it should be precisely differentiated and appropriately managed. We report such a case of intramedullary ependymoma of the cervical spinal cord mimicking metatstatic recurrent lymphoma and causing cord compression. A 50-year-old man developed intramedullary ependymoma of the cervical spinal cord 1.5 years following chemoradiation for Waldeyer's ring lymphoma. He presented with a 2-month history of neck pain, progressive upper- and lower-extremity numbness and weakness, and bowel and bladder dysfunction. Magnetic resonance imaging revealed an intramedullary expansive lesion extending from C4 to C6 levels of the cervical spinal cord. The clinical and radiological findings were suggestive of malignant process. A comprehensive investigation failed to detect another site of disease. He underwent operation, and the tumour was subtotally resected. The patient's neurological deficits improved subsequently. The development of the intramedullary ependymoma following treating lymphoma has not been reported. We describe the clinical, radiological and pathological findings of this case and review the literature.
authors.affiliation: Department of Radiation Oncology, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran. mohpanah@sums.ac.ir
authors.forename: M
authors.initials: M
authors.lastname: Mohammadianpanah
authors.forename: M
authors.initials: M
authors.lastname: Vasei
authors.forename: A
authors.initials: A
authors.lastname: Mosalaei
authors.forename: S
authors.initials: S
authors.lastname: Omidvari
authors.forename: N
authors.initials: N
authors.lastname: Ahmadloo
mesh_terms: D002574:Cervical Vertebrae; D003937:Diagnosis, Differential; D004806:Ependymoma / Q000175:diagnosis* / Q000188:drug therapy / Q000532:radiotherapy; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy / Q000532:radiotherapy; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis; D016609:Neoplasms, Second Primary / Q000175:diagnosis*; D009959:Oropharyngeal Neoplasms / Q000188:drug therapy / Q000532:radiotherapy; D011782:Quadriplegia / Q000209:etiology; D013117:Spinal Cord Compression / Q000209:etiology*; D013120:Spinal Cord Neoplasms / Q000175:diagnosis*