title: Myth: blood transfusion is effective for sickle cell anemia-associated priapism.
abstract: OBJECTIVE
  Priapism is a recognized complication of sickle cell anemia (SCA). When initial conventional treatments fail, simple or exchange blood transfusion has been advocated as a secondary intervention. However, recent literature suggests this may not be an effective therapy and may have significant neurologic sequelae. This paper reviews and summarizes the effectiveness and risks of blood transfusion compared with conventional priapism therapy.
  
  
  METHODS
  All relevant papers identified from a MEDLINE search were systematically examined for data related to the use of blood transfusion in the setting of priapism due to SCA. The effectiveness of conventional therapy was compared with transfusion therapy using the outcome of "time to detumescence" (TTD). In addition, papers documenting adverse neurologic sequela were reviewed and summarized.
  
  
  RESULTS
  Forty-two case reports were identified containing complete information with regard to patient age and TTD. The mean TTD was 8.0 days with conventional therapy (n = 16) and 10.8 days with blood transfusion therapy (n = 26). Adverse neurologic sequelae from blood transfusion therapy was described in 9 cases, with long term outcomes ranging from complete resolution to severe residual deficits.
  
  
  CONCLUSIONS
  The current literature does not support the contention that blood transfusion is an effective therapy in the treatment of priapism due to SCA, as defined by an acceleration of TTD. In fact, numerous reports suggest that serious neurologic sequelae may result from this treatment. We feel the routine use of this therapy cannot be recommended.
authors.affiliation: Department of Emergency Medicine, Keck/USC School of Medicine, Los Angeles, CA 90033, USA.
authors.forename: Andrew L
authors.initials: AL
authors.lastname: Merritt
authors.forename: Christopher
authors.initials: C
authors.lastname: Haiman
authors.forename: Sean O
authors.initials: SO
authors.lastname: Henderson
mesh_terms: D000755:Anemia, Sickle Cell / Q000150:complications*; D001049:Apnea / Q000209:etiology; D001919:Bradycardia / Q000209:etiology; D006261:Headache / Q000209:etiology; D006801:Humans; D008297:Male; D009325:Nausea / Q000209:etiology; D010291:Paresis / Q000209:etiology; D011317:Priapism / Q000209:etiology / Q000628:therapy*; D012640:Seizures / Q000209:etiology; D020521:Stroke / Q000209:etiology; D065227:Transfusion Reaction