Nine new isoxuxuarine-type triterpene dimers from Maytenus chuchuhuasca.
Nine new isoxuxuarine-type triterpene dimers, named isoxuxuarines B alpha (1), B beta (2), 7,8-dihydro-B alpha (3), C alpha (4), C beta (5), 7,8-dihydro-C alpha (6), D alpha (7), D beta (8), and 7,8-dihydro-D alpha (9), were isolated from the South American medicinal plant 'xuxuá' (Maytenus chuchuhuasca). The structures were elucidated on the basis of several spectroscopic analyses, including 2D-NMR experiments, MS spectra, and CD spectral studies. The isolations and structure elucidations of the new triterpene dimers are presented, and a rationale for the divergent formation of the regiochemical and stereochemical isomers of triterpene dimers is discussed.
Shirota
Osamu
O
Division of Pharmacognosy and Phytochemistry, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya, Tokyo 158-8501, Japan. shirota@kph.bunri-u.ac.jp
Sekita
Setsuko
S
Satake
Motoyoshi
M
Morita
Hiroshi
H
Takeya
Koichi
K
Itokawa
Hideji
H
D019281:Dimerization; D029755:Maytenus; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification*
D010936:Plant Extracts; D014315:Triterpenes