title: Natural history of benign prostate hyperplasia.
abstract: BACKGROUND
  Benign prostate hyperplasia is one of the most common diseases affecting the health of the aging males. Watchful waiting is an acceptable management strategy for benign prostate hyperplasia in which the patient is monitored by the physician but receives no active intervention. The epidemiological data on this are lacking in China. Our study was designed to evaluate the changes of signs and symptoms of patients with benign prostate hyperplasia during management by watchful waiting in China.
  
  
  METHODS
  One hundred and forty-five patients with benign prostate hyperplasia aged > 50 years were enrolled in management by watchful waiting. All the patients were visited every 6 months and were given an International Prostate Symptom Score and Quality of Life questionnaire to complete. They also had uroflowmetry and were assessed using ultrasonography to get the volume of prostate, transition zone and amount of residual urine. The Student's t test, the Chi-square test, and variance analysis were used in the statistical analysis.
  
  
  RESULTS
  All patients were visited after 6 months, the mean volume of transitional zone was found to have increased by 1.6 ml (P < 0.01), International Prostate Symptom Score was increased by 0.8 (P < 0.01) and Quality of Life was increased by 0.2 (P < 0.01), and there was no statistical change in other data. Among these patients, 17.9% (26/145) visited again after 12 months when the data failed to show a statistically significant difference among the three groups (0, 6, and 12 months).
  
  
  CONCLUSIONS
  After one year's follow-up, the progression of benign prostate hyperplasia was slow and the clinical data did not undergo much change.
authors.affiliation: Department of Urology, Peking University First Hospital, Beijing 100034, China.
authors.forename: Shi-liang
authors.initials: SL
authors.lastname: Wu
authors.forename: Ning-chen
authors.initials: NC
authors.lastname: Li
authors.forename: Yun-xiang
authors.initials: YX
authors.lastname: Xiao
authors.forename: Jie
authors.initials: J
authors.lastname: Jin
authors.forename: Shao-peng
authors.initials: SP
authors.lastname: Qiu
authors.forename: Zhang-qun
authors.initials: ZQ
authors.lastname: Ye
authors.forename: Chui-ze
authors.initials: CZ
authors.lastname: Kong
authors.forename: Guang
authors.initials: G
authors.lastname: Sun
authors.forename: Yan-qun
authors.initials: YQ
authors.lastname: Na
mesh_terms: D000368:Aged; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011470:Prostatic Hyperplasia / Q000523:psychology / Q000628:therapy*; D011788:Quality of Life