[Cytogenetic and biochemical assay of an unidirectional effect of chronic combined exposure of laboratory animals to isoeffective concentrations of chemical substances].
Chronic combined exposure to low concentrations of chemical substances (equal to the maximal admissible limits for space vehicles) is fraught with an increase in chromosomal aberrations in bone marrow cells as compared with the spontaneous chromosome aberration rate. In addition to the cytogenetic evidence, there were also statistical phase shifts in metabolic parameters of erythrocytes (enzymes involved in the basal metabolism and a number of metabolites), leukocyte count in peripheral blood, and the total quantity of karyocytes in the bone marrow. No significant changes were found in organs of the immune and reproductive systems.
Barantseva
M Iu
MIu
Ivanova
S M
SM
Pakhomova
A A
AA
Nikitin
E I
EI
Vorozhtsova
S V
SV
D000096:Acetone / Q000008:administration & dosage / Q000009:adverse effects*; D000393:Air Pollutants / Q000009:adverse effects*; D000641:Ammonia / Q000008:administration & dosage / Q000009:adverse effects*; D000818:Animals; D001854:Bone Marrow Cells / Q000187:drug effects* / Q000473:pathology; D002869:Chromosome Aberrations / Q000139:chemically induced*; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D004780:Environment, Controlled; D004781:Environmental Exposure / Q000009:adverse effects*; D000431:Ethanol / Q000008:administration & dosage / Q000009:adverse effects*; D005500:Follow-Up Studies; D008297:Male; D020714:Maximum Tolerated Dose; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D051381:Rats; D017208:Rats, Wistar; D018531:Spacecraft
D000393:Air Pollutants; D004338:Drug Combinations; D000096:Acetone; D000431:Ethanol; D000641:Ammonia