Erythropoietin delays disease onset in an amyotrophic lateral sclerosis model.
Erythropoietin (Epo) has been shown in the recent years to have neuroprotective activity in a variety of settings. In this study, we investigated its impact on the progression of paralysis in a mouse model simulating the human disorder amyotrophic lateral sclerosis (ALS). We found that Epo can delay the onset of motor deterioration in transgenic SOD G93A mice without prolonging their survival. Notably this effect was selective for the females only. These initial findings encourage further investigation of this biological avenue in the search for improved remedies for this fatal disease.
Grunfeld
Jonathan F
JF
Department of Neurology, Asaf HaRofeh Medical Center, Tel Aviv University, Sackler School of Medicine, Israel. jonathangrunfeld@yahoo.com
Barhum
Yael
Y
Blondheim
Netta
N
Rabey
Jose-Martin
JM
Melamed
Eldad
E
Offen
Daniel
D
D000225:Adenine; D000690:Amyotrophic Lateral Sclerosis / Q000235:genetics / Q000473:pathology / Q000503:physiopathology* / Q000517:prevention & control*; D000818:Animals; D018450:Disease Progression; D004921:Erythropoietin / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D006147:Guanine; D006801:Humans; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D009043:Motor Activity / Q000187:drug effects; D009046:Motor Neurons / Q000473:pathology; D009154:Mutation; D018696:Neuroprotective Agents / Q000008:administration & dosage / Q000494:pharmacology*; D011994:Recombinant Proteins; D012737:Sex Factors; D013116:Spinal Cord / Q000473:pathology; D013482:Superoxide Dismutase / Q000235:genetics; D000072105:Superoxide Dismutase-1; D013997:Time Factors
D018696:Neuroprotective Agents; D011994:Recombinant Proteins; C000606290:SOD1 protein, human; D004921:Erythropoietin; D006147:Guanine; C000606291:Sod1 protein, mouse; D013482:Superoxide Dismutase; D000072105:Superoxide Dismutase-1; D000225:Adenine