Asarum sieboldii extracts attenuate growth, acid production, adhesion, and water-insoluble glucan synthesis of Streptococcus mutans.
Asarum sieboldii has been used in traditional folk medicine to treat dental caries and periodontal disease. In the present study, we investigated the inhibitory effect of the ethanol and aqueous extracts of A. sieboldii on the growth, acid production, adhesion, and water-insoluble glucan synthesis of Streptococcus mutans. The ethanol and aqueous extracts of A. sieboldii inhibited the growth and acid production of S. mutans. In the bacterial adherence assay, the ethanol and aqueous extracts of A. sieboldii significantly lowered the adherence of S. mutans. We also found that the ethanol and aqueous extracts of A. sieboldii significantly inhibited the synthesis of water-insoluble glucan by crude glucosyltransferase. These results suggest that A. sieboldii extracts may inhibit the caries-inducing properties of S. mutans. Further studies are necessary to clarify the active constituents of A. sieboldii extracts responsible for such biomolecular activities.
Yu
Hyeon-Hee
HH
Department of Food and Nutrition, Kunsan National University, Kunsan, Republic of Korea.
Seo
Se-Jeong
SJ
Hur
Jong-Moon
JM
Lee
Heung-Soo
HS
Lee
Young-Eun
YE
You
Yong-Ouk
YO
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D030023:Asarum / Q000737:chemistry*; D001422:Bacterial Adhesion / Q000187:drug effects*; D004791:Enzyme Inhibitors / Q000494:pharmacology; D000431:Ethanol; D005936:Glucans / Q000096:biosynthesis*; D005964:Glucosyltransferases / Q000037:antagonists & inhibitors / Q000378:metabolism; D010936:Plant Extracts / Q000494:pharmacology*; D012995:Solubility; D013295:Streptococcus mutans / Q000187:drug effects* / Q000254:growth & development / Q000502:physiology; D014867:Water
D000900:Anti-Bacterial Agents; D004791:Enzyme Inhibitors; D005936:Glucans; D010936:Plant Extracts; D014867:Water; D000431:Ethanol; D005964:Glucosyltransferases