Usefulness of indomethacin for patent ductus arteriosus in full-term infants.
The aim of this retrospective study was to evaluate the effectiveness of indomethacin therapy for patent ductus arteriosus (PDA) in full-term infants. The patients were 41 full-term infants with a PDA birth weight (BW) > or =2500 g and a gestational age (GA) > or =37 weeks. The echocardiographic evaluation and medical management of PDA in these infants was similar to that for PDA in low-birth-weight infants. Indomethacin (0.2-0.25 mg/kg/dose) was given intravenously at 12-24-hour intervals within 23 days of birth. Of the 41 infants, 12 showed complete closure, and 13 showed improvement of clinical symptoms. These 25 infants were classified as the responder group (61%). The other 16 infants, who did not show improvement in clinical symptoms, were classified as the nonresponder group. Statistical analysis revealed no difference between the two groups regarding GA, BW, Apgar score at 1 minute, minimum diameter of the DA before treatment, the average age at the initiation of treatment, and DA flow pattern. No severe adverse reactions were observed in any infant. Indomethacin therapy appears to be an effective medical treatment option for PDA in full-term symptomatic infants prior to considering surgical treatment.
Takami
Takeshi
T
Department of Pediatrics, Tokyo Medical University, 6-7-1 Nishi-Shinjuku, 160-0023 Shinjuku-ku, Tokyo, Japan. takami@tokyo-med.ac.jp
Yoda
Hitoshi
H
Kawakami
Tadashi
T
Yamamura
Hideshi
H
Nakanishi
Toshio
T
Nakazawa
Makoto
M
Takei
Yukito
Y
Miyajima
Tasuku
T
Hoshika
Akinori
A
D016861:Cyclooxygenase Inhibitors / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D004374:Ductus Arteriosus, Patent / Q000000981:diagnostic imaging / Q000188:drug therapy*; D006801:Humans; D007213:Indomethacin / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D007231:Infant, Newborn; D012189:Retrospective Studies; D047929:Term Birth; D016896:Treatment Outcome; D014463:Ultrasonography
D016861:Cyclooxygenase Inhibitors; D007213:Indomethacin