Dysregulation of apoptotic death in the pathogenesis of virus-induced cytogenetic instability of blood lymphocytes.
The cytogenetic status and activity of regulatory systems for stability of the cell genome were evaluated in patients with chronic viral persistence. Hepatitis B and C viruses damage the chromosome apparatus of peripheral blood lymphocytes. Cytogenetic instability of immunocompetent cells during chronic viral infection was associated with inhibition of DNA excision repair system and dysregulation of apoptosis in target cells.
Ryazantseva
N V
NV
Siberian State Medical University, Tomsk. ryazan@mail.tomsknet.ru
Novitskii
V V
VV
Zhukova
O B
OB
Radzivil
T T
TT
Mikheev
S L
SL
Chechina
O E
OE
Zima
A P
AP
Shilov
B V
BV
D000328:Adult; D017209:Apoptosis / Q000235:genetics / Q000502:physiology*; D043171:Chromosomal Instability / Q000235:genetics*; D002869:Chromosome Aberrations; D005260:Female; D016650:Fluorescein-5-isothiocyanate; D016174:Hepacivirus; D006515:Hepatitis B virus; D006525:Hepatitis, Viral, Human / Q000503:physiopathology* / Q000821:virology; D006801:Humans; D007150:Immunohistochemistry; D008214:Lymphocytes / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D012588:Scintillation Counting
D016650:Fluorescein-5-isothiocyanate