title: [Pulmonary toxicity associated with sirolimus therapy in liver transplantation].
abstract: Sirolimus is a potent immunosuppressive drug that began to be used in the last few years. This drug was initially used in renal transplantation but its use in other solid organ transplantations such as liver, heart, lung and pancreas, has been increasing. Sirolimus is indicated in rescue therapies and to reduce the secondary toxic effects of calcineurin inhibitors. However, this drug has been associated with infrequent but severe pulmonary toxicity and cases of interstitial pneumonitis, bronchiolitis obliterans with organizing pneumonia, and alveolar proteinosis have been described. We present the case of a male liver transplant recipient who developed interstitial pneumonitis associated with sirolimus use.
authors.affiliation: Unidad de Hepatología-Trasplante Hepático, Servicio de Aparato Digestivo, Hospital Universitario Carlos Haya, Málaga, España. miguel.jimenez.sspa@juntadeandalucia.es
authors.forename: Miguel
authors.initials: M
authors.lastname: Jiménez Pérez
authors.forename: Raúl
authors.initials: R
authors.lastname: Olmedo Martín
authors.forename: David
authors.initials: D
authors.lastname: Marín García
authors.forename: Juan Miguel
authors.initials: JM
authors.lastname: Lozano Rey
authors.forename: Jesús
authors.initials: J
authors.lastname: de la Cruz Lombardo
authors.forename: Juan Miguel
authors.initials: JM
authors.lastname: Rodrigo López
mesh_terms: D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D016031:Liver Transplantation; D017563:Lung Diseases, Interstitial / Q000139:chemically induced*; D008297:Male; D008875:Middle Aged; D020123:Sirolimus / Q000009:adverse effects*
chemical_list: D007166:Immunosuppressive Agents; D020123:Sirolimus