title: Naringin time-dependently lowers hepatic cholesterol biosynthesis and plasma cholesterol in rats fed high-fat and high-cholesterol diet.
abstract: The flavonoid naringin was investigated for its differential effects on hepatic cholesterol regulation when supplemented for 3 weeks and 6 weeks. Sprague-Dawley rats were fed a high-fat and high-cholesterol diet with or without 0.02% naringin supplement for 3 or 6 weeks. Supplementation with naringin resulted in a significant decrease in the plasma cholesterol and triglyceride concentrations in the 6-week trial. Although high-density lipoprotein (HDL)-cholesterol was not altered in either trial, the HDL-cholesterol/total cholesterol ratio (in percent) was significantly higher, and the atherogenic index was significantly lower in the naringin-supplemented groups in the 6-week trial. The hepatic cholesterol content was also lowered by naringin supplementation only in the 6-week trial. The hepatic 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity was lower in the rats supplemented with naringin for 6 weeks, while the hepatic acyl-coenzyme A:cholesterol acyltransferase activity was lower in both the 3-week and 6-week trials. Results indicate that supplementation with naringin for 3 weeks did not exhibit a hypolipidemic effect when given with a HFHC diet. Naringin can, however, be beneficial for lowering hepatic cholesterol biosynthesis and levels of plasma lipids when supplemented for 6 weeks in this animal model.
authors.affiliation: Department of Nutrition Care Services, Seoul National University Bundang Hospital, Gyeonggi-Do, Republic of Korea.
authors.forename: So-Yeon
authors.initials: SY
authors.lastname: Kim
authors.forename: Hye-Jin
authors.initials: HJ
authors.lastname: Kim
authors.forename: Mi-Kyung
authors.initials: MK
authors.lastname: Lee
authors.forename: Seon-Min
authors.initials: SM
authors.lastname: Jeon
authors.forename: Gyeong-Min
authors.initials: GM
authors.lastname: Do
authors.forename: Eun-Young
authors.initials: EY
authors.lastname: Kwon
authors.forename: Yun-Young
authors.initials: YY
authors.lastname: Cho
authors.forename: Dong-Ju
authors.initials: DJ
authors.lastname: Kim
authors.forename: Kyu-Shik
authors.initials: KS
authors.lastname: Jeong
authors.forename: Yong Bok
authors.initials: YB
authors.lastname: Park
authors.forename: Tae Yul
authors.initials: TY
authors.lastname: Ha
authors.forename: Myung-Sook
authors.initials: MS
authors.lastname: Choi
mesh_terms: D000818:Animals; D002784:Cholesterol / Q000032:analysis / Q000096:biosynthesis* / Q000097:blood; D002791:Cholesterol, Dietary / Q000008:administration & dosage*; D008076:Cholesterol, HDL / Q000097:blood; D004041:Dietary Fats / Q000008:administration & dosage*; D004435:Eating; D044950:Flavanones / Q000008:administration & dosage*; D006903:Hydroxymethylglutaryl CoA Reductases / Q000378:metabolism; D008099:Liver / Q000737:chemistry / Q000187:drug effects* / Q000378:metabolism*; D009929:Organ Size; D051381:Rats; D017207:Rats, Sprague-Dawley; D002785:Sterol O-Acyltransferase / Q000378:metabolism; D014280:Triglycerides / Q000097:blood; D015430:Weight Gain
chemical_list: D002791:Cholesterol, Dietary; D008076:Cholesterol, HDL; D004041:Dietary Fats; D044950:Flavanones; D014280:Triglycerides; D002784:Cholesterol; D006903:Hydroxymethylglutaryl CoA Reductases; D002785:Sterol O-Acyltransferase; C005273:naringenin