title: Tularemia re-emerging in European part of Turkey after 60 years.
abstract: The aim of this study was to investigate a tularemia outbreak in the Thrace region of Turkey. The outbreak occurred in Demirkoy village of Edirne, in 2005. Of 400 villagers, 266 were examined and their sera were taken. Throat swabs and lymph node aspirates were cultured. Specific antibodies in patients and domestic animals were screened by a microagglutination test. PCR assays and cultures of the samples of patients, animal tissues, and water sources were performed, along with active surveillance to identify risk factors. Seven out of 10 cases were diagnosed as oropharyngeal form; the remaining three patients were asymptomatic. The cultures for tularemia were negative; however, PCR assays were positive in one lymph node aspirate and in water from one spring. Some animals had the specific antibody at low levels. Increased rodent population in the vicinity, exposure to wild rabbits, and drinking from one of the springs were identified as risk factors with the risk ratios (and 95% confidence interval) of 10.5 (10.3-10.7), 6.5 (5.43-7.57), and 2.1 (1.1-2.5), respectively. Therapeutic and preventive measures were taken. When tularemia cases have been detected in a region even a few decades earlier, tularemia should be considered in the differential diagnosis of patients.
authors.affiliation: Department of Microbiology and Clinical Microbiology, Medical Faculty, Trakya University, Edirne, Turkey. sabangurcan@trakya.edu.tr
authors.forename: Saban
authors.initials: S
authors.lastname: Gürcan
authors.forename: Muzaffer
authors.initials: M
authors.lastname: Eskiocak
authors.forename: Gamze
authors.initials: G
authors.lastname: Varol
authors.forename: Cem
authors.initials: C
authors.lastname: Uzun
authors.forename: Müşerref
authors.initials: M
authors.lastname: Tatman-Otkun
authors.forename: Nermin
authors.initials: N
authors.lastname: Sakru
authors.forename: Aynur
authors.initials: A
authors.lastname: Karadenizli
authors.forename: Cigdem
authors.initials: C
authors.lastname: Karagöl
authors.forename: Metin
authors.initials: M
authors.lastname: Otkun
mesh_terms: D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood; D021821:Communicable Diseases, Emerging / Q000453:epidemiology* / Q000382:microbiology; D004196:Disease Outbreaks; D005604:Francisella tularensis / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification; D006801:Humans; D051379:Mice; D016133:Polymerase Chain Reaction / Q000379:methods; D011817:Rabbits; D012307:Risk Factors; D014406:Tularemia / Q000453:epidemiology* / Q000382:microbiology; D014421:Turkey / Q000453:epidemiology
chemical_list: D000907:Antibodies, Bacterial