Synthesis of fluorescent molecular probes specific for the receptor of blepharismone, a mating-inducing pheromone of the ciliate Blepharisma japonicum.
Blepharismone (gamone 2) is a mating-inducing pheromone of the ciliate Blepharisma japonicum. N-Pyrenylbutyryl-blepharismone and N-biphenylacetyl-blepharismone, which are fluorescent derivatives of blepharismone, were synthesized as molecular probes for the gamone 2 receptor. Further, we proved that they have inhibitory activities against the blepharismone-induced monotypic pairing of B. japonicum.
Uruma
Yoshiyuki
Y
Department of Material Science, Graduate School of Science, Osaka City University, Osaka 558-8585, Japan.
Sugiura
Mayumi
M
Harumoto
Terue
T
Usuki
Yoshinosuke
Y
Iio
Hideo
H
D000627:Aminophenols; D000818:Animals; D005456:Fluorescent Dyes / Q000138:chemical synthesis*; D062385:Hydroxybenzoates / Q000037:antagonists & inhibitors* / Q000138:chemical synthesis; D007773:Lactates; D015800:Protozoan Proteins / Q000037:antagonists & inhibitors; D043563:Receptors, Pheromone / Q000032:analysis / Q000037:antagonists & inhibitors; D012724:Sex Attractants / Q000037:antagonists & inhibitors*
D000627:Aminophenols; D005456:Fluorescent Dyes; D062385:Hydroxybenzoates; D007773:Lactates; D015800:Protozoan Proteins; D043563:Receptors, Pheromone; D012724:Sex Attractants; C012329:blepharismone