99mTc(CO)3-VIP analogues: preparation and evaluation as tumor imaging agent.
Vasoactive intestinal peptide (VIP) receptors are expressed abundantly on many types of tumors and, hence, radiolabeled VIP analogues are being explored for tumor imaging and therapy. Here, we report synthesis of three VIP analogues and their radiolabeling with (99m)Tc via a novel tricarbonyl synthon. The radiolabeled product could be prepared in high yields (>95%) and stability. In vitro studies showed significant uptake of (99m)Tc(CO)((3))-VP05 in human colon carcinoma cells. Biodistribution studies in animal tumor model showed 0.4-1%ID/g tumor uptake.
Kothari
Kanchan
K
Radiopharmaceuticals Division, Bhabha Atomic Research Centre, Mumbai 400085, India.
Prasad
Sudhanand
S
Korde
Aruna
A
Mukherjee
Archana
A
Mathur
Archana
A
Jaggi
Manu
M
Venkatesh
Meera
M
Pillai
Ambikalmajan M R
AM
Mukherjee
Rama
R
Ramamoorthy
Natesan
N
D000595:Amino Acid Sequence; D000818:Animals; D003110:Colonic Neoplasms / Q000000981:diagnostic imaging*; D006801:Humans; D007553:Isotope Labeling; D051379:Mice; D015609:Organotechnetium Compounds / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D011877:Radionuclide Imaging; D014660:Vasoactive Intestinal Peptide / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000493:pharmacokinetics
D015609:Organotechnetium Compounds; C519829:techentium 99m tricarbonyl VD5 peptide; C519828:technetium 99m tricarbonyl VD4 peptide; C519827:technetium 99m tricarbonyl VP05 peptide; D014660:Vasoactive Intestinal Peptide