Emergence of VanD-type vancomycin-resistant Enterococcus faecium in Stockholm, Sweden.
A vancomycin-resistant Enterococcus faecium isolate from the urine of a liver transplant patient in Stockholm was found to contain a vanD gene. The sequence of the vanD PCR product shared 100% identity with the vanD5 allele. The isolate was resistant to a relatively high level of vancomycin (128 mg/L) and a low level of teicoplanin (4 mg/L). This is the first VanD-type vancomycin-resistant E. faecium isolate reported in Sweden. The emergence of this strain reinforces the necessity of infection control efforts to interrupt the spread of these organisms.
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Division of Clinical Bacteriology, Department of Laboratory Medicine, Karolinska Institute, Karolinska University Hospital Huddinge, Stockholm, Sweden.
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D000483:Alleles; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000235:genetics; D016984:Enterococcus faecium / Q000187:drug effects* / Q000302:isolation & purification; D005798:Genes, Bacterial; D016908:Gram-Positive Bacterial Infections / Q000382:microbiology* / Q000652:urine; D006801:Humans; D016031:Liver Transplantation; D010453:Peptide Synthases / Q000235:genetics; D011183:Postoperative Complications / Q000382:microbiology* / Q000652:urine; D013548:Sweden; D017334:Teicoplanin / Q000494:pharmacology; D014640:Vancomycin / Q000494:pharmacology*; D020713:Vancomycin Resistance / Q000235:genetics
D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D017334:Teicoplanin; D014640:Vancomycin; D010453:Peptide Synthases; C122181:VanD protein, Enterococcus faecium