title: Giardia lamblia trophozoites in gastric biopsies.
abstract: To assess the prevalence of gastric giardiasis in gastric biopsies of patients with carcinoma stomach and in patients taking treatment for duodenal ulcer. Gastric biopsy specimens from 54 patients of carcinoma stomach and 100 antral biopsies from patients taking treatment for duodenal ulcer were included in the study. Sections were stained with haematoxylin and eosin, methylene blue and May Grunwald-Giemsa stains and examined for presence of Giardia lamblia trophozoites. Eight out of 54 (14.9%) biopsies of gastric carcinoma patients harboured trophozoites of Giardia lamblia. Associated H. pylori infection was present in all biopsies (8/8; 100%). Atrophy and intestinal metaplasia was present in 62.5% (5/8) and 25% (2/8) cases respectively. Sections from seven out of 35 patients (20%) taking treatment for duodenal ulcer showed presence of G. lamblia. H. pylori infection, gastritis and atrophy were found in 85.7% (6/7), 71.4% (5/7) and 28.6% (2/7) cases respectively. First gastric biopsy in these patients was negative for G. lamblia but 2nd and 3rd biopsies were positive. A careful search for G. lamblia trophozoites should be made while examining the gastric biopsies, especially in patients with carcinoma stomach, intestinal metaplasia, atrophic gastritis and those taking treatment for duodenal ulcer. This may help in indirect diagnosis of clinically unsuspected cases of intestinal giardiasis and may explain persistence of vague upper gastrointestinal tract (UGIT) symptoms despite clearance of H. pylori in patients on anti-ulcer therapy.
authors.affiliation: Department of Pathology, M.L.N. Medical College, Allahabad 211001. vatsala.m@rediffmail.com
authors.forename: Vatsala
authors.initials: V
authors.lastname: Misra
authors.forename: S P
authors.initials: SP
authors.lastname: Misra
authors.forename: Manisha
authors.initials: M
authors.lastname: Dwivedi
authors.forename: P A
authors.initials: PA
authors.lastname: Singh
mesh_terms: D000818:Animals; D000897:Anti-Ulcer Agents / Q000627:therapeutic use; D001706:Biopsy; D002277:Carcinoma / Q000469:parasitology*; D004381:Duodenal Ulcer / Q000188:drug therapy* / Q000469:parasitology; D005753:Gastric Mucosa / Q000469:parasitology; D005757:Gastritis, Atrophic / Q000469:parasitology*; D016829:Giardia lamblia / Q000254:growth & development / Q000302:isolation & purification*; D005873:Giardiasis / Q000453:epidemiology* / Q000469:parasitology; D016481:Helicobacter Infections / Q000453:epidemiology; D016480:Helicobacter pylori / Q000302:isolation & purification; D006801:Humans; D007422:Intestines / Q000473:pathology; D011230:Precancerous Conditions / Q000469:parasitology; D015995:Prevalence; D013274:Stomach Neoplasms / Q000469:parasitology*; D053058:Trophozoites / Q000254:growth & development
chemical_list: D000897:Anti-Ulcer Agents