title: Synthesis and biological evaluation of novel compounds related to 1-arylnaphthalene lignans and isoquinolines.
abstract: Novel compounds designed as hybrids of 1-arylnaphthalene lignans with isoquinoline alkaloids were prepared and evaluated for their cytotoxicities on human tumor cell lines, such as A549, Hela, PC-3, CNE, BEL-7404, and KB. Some of the synthetic compounds exhibited their IC50 values on selected cell lines at 10(-6) M scale. The preliminary CoMFA molecular-modelling studies of these synthetic analogues were also performed.
authors.affiliation: Department of Traditional Chinese Medicine and Natural Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310031, PR China.
authors.forename: Hongxia
authors.initials: H
authors.lastname: Ding
authors.forename: Wei
authors.initials: W
authors.lastname: Lu
authors.forename: Haibo
authors.initials: H
authors.lastname: Li
authors.forename: Leixiang
authors.initials: L
authors.lastname: Yang
authors.forename: Qijun
authors.initials: Q
authors.lastname: Zhang
authors.forename: Changxin
authors.initials: C
authors.lastname: Zhou
authors.forename: Xiumei
authors.initials: X
authors.lastname: Wu
authors.forename: Olivier
authors.initials: O
authors.lastname: Baudoin
authors.forename: Junchao
authors.initials: J
authors.lastname: Cai
authors.forename: Françoise
authors.initials: F
authors.lastname: Guéritte
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhao
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D006801:Humans; D007546:Isoquinolines / Q000737:chemistry* / Q000494:pharmacology*; D017705:Lignans / Q000737:chemistry* / Q000494:pharmacology*; D008958:Models, Molecular; D015394:Molecular Structure
chemical_list: D000970:Antineoplastic Agents; D007546:Isoquinolines; D017705:Lignans