Enterostatin (APGPR) enhances memory consolidation in mice.
Enterostatin (APGPR) is a pentapeptide released from its precursor protein, procolipase. We found for the first time that enterostatin has memory-enhancing activity. Enterostatin enhanced memory consolidation after central or oral administration at a dose of 10 nmol/mouse or 300 mg/kg, respectively, in a step-through type passive avoidance test in mice. The memory-enhancing activity of enterostatin was inhibited by pretreatment with lorglumide, an antagonist for cholecystokinin 1 (CCK1) receptor. However, enterostatin had no affinity for CCK receptors. These results suggest that enterostatin improves memory retention through CCK release.
Ohinata
Kousaku
K
Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Gokasho Uji, Kyoto 611-0011, Japan.
Sonoda
Soushi
S
Shimano
Tomoko
T
Yoshikawa
Masaaki
M
D000284:Administration, Oral; D000818:Animals; D001362:Avoidance Learning; D003089:Colipases / Q000008:administration & dosage / Q000494:pharmacology* / Q000502:physiology; D004792:Enzyme Precursors; D007276:Injections, Intraventricular; D008297:Male; D008568:Memory / Q000187:drug effects* / Q000502:physiology; D051379:Mice; D011377:Proglumide / Q000031:analogs & derivatives / Q000494:pharmacology; D011498:Protein Precursors / Q000008:administration & dosage / Q000494:pharmacology* / Q000502:physiology; D043886:Receptor, Cholecystokinin A / Q000037:antagonists & inhibitors / Q000502:physiology
D003089:Colipases; D004792:Enzyme Precursors; D011498:Protein Precursors; D043886:Receptor, Cholecystokinin A; C037107:procolipase; D011377:Proglumide; C048181:lorglumide