Sustained release of hydrophobic and hydrophilic drugs from a floating dosage form.
Floating dosage forms enable the sustained delivery of drugs in the gastro-intestinal tract. In this study, a type of multi-unit floating gel bead was synthesized with calcium alginate, sunflower oil, and a drug of interest through an emulsification/gelation process. The alginate beads with oil addition were able to continuously float over the medium for 24h under constant agitation while the non-oily beads could not. Three kinds of drugs with different hydrophilicities, ibuprofen, niacinamide and metoclopramide HCl, were tested in the study. The hydrophobic drug ibuprofen was released in a sustained manner for 24h, due to the oil partitioning. With suitable modification, the beads were able to also release the hydrophilic drugs, niacinamide and metoclopramide HCl, for a similar duration. Therefore a floating dosage form that is able to sustain release both hydrophobic and hydrophilic drugs within its extended gastric retention time has been developed.
Tang
Yong-Dan
YD
School of Materials Science & Engineering, Nanyang Technological University, Blk N4.1-02-06, 50, Nanyang Avenue, Singapore 639798, Singapore.
Venkatraman
Subbu S
SS
Boey
Freddy Y C
FY
Wang
Li-Wei
LW
D000464:Alginates / Q000737:chemistry; D003692:Delayed-Action Preparations / Q000737:chemistry* / Q000493:pharmacokinetics; D005750:Gastric Juice / Q000737:chemistry; D005782:Gels; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D007052:Ibuprofen / Q000737:chemistry* / Q000493:pharmacokinetics; D008787:Metoclopramide / Q000737:chemistry* / Q000493:pharmacokinetics; D008855:Microscopy, Electron, Scanning; D009536:Niacinamide / Q000737:chemistry* / Q000493:pharmacokinetics; D010316:Particle Size; D010938:Plant Oils / Q000737:chemistry; D011109:Polymethacrylic Acids / Q000737:chemistry; D011142:Polyvinyl Alcohol / Q000737:chemistry; D000074242:Sunflower Oil; D014867:Water / Q000032:analysis / Q000737:chemistry
D000464:Alginates; D003692:Delayed-Action Preparations; D005782:Gels; D006603:Hexuronic Acids; D010938:Plant Oils; D011109:Polymethacrylic Acids; D000074242:Sunflower Oil; D014867:Water; C038300:methylmethacrylate-methacrylic acid copolymer; D009536:Niacinamide; D020723:Glucuronic Acid; D011142:Polyvinyl Alcohol; D008787:Metoclopramide; D007052:Ibuprofen