Acridone and furoquinoline alkaloids from Teclea gerrardii (Rutaceae: Toddalioideae) of southern Africa.
The combined hexane/CH(2)Cl(2) extract of the stem bark of Teclea gerrardii (Rutaceae: Toddalioideae) has yielded two acridone alkaloids, 3-hydroxy-1-methoxy-N-methylacridone (tegerrardin A) (1) and 3-hydroxy-N-methyl-1-(gamma,gamma-dimethylallyloxy)acridone (tegerrardin B) (2), three known acridones (3-5), two known furoquinolines (6,7), and the acridone precursor tecleanone (8). Arborinine (3) and evoxine (6) displayed moderate antiplasmodial activity against the CQS D10 strain of Plasmodium falciparum, with IC(50) values of 12.3 and 24.5 microM, respectively.
Waffo
Alain F Kamdem
AF
School of Chemistry, University of KwaZulu-Natal, Howard College Campus, 4041, Durban, South Africa.
Coombes
Philip H
PH
Crouch
Neil R
NR
Mulholland
Dulcie A
DA
El Amin
Sawsan M M
SM
Smith
Peter J
PJ
D000166:Acridines / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D054831:Acridones; D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D000818:Animals; D000962:Antimalarials / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D002163:Cameroon; D018547:Plant Stems / Q000737:chemistry; D010963:Plasmodium falciparum / Q000187:drug effects*; D011804:Quinolines / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D027821:Rutaceae / Q000737:chemistry* / Q000254:growth & development; D013019:South Africa
D000166:Acridines; D054831:Acridones; D000470:Alkaloids; D000962:Antimalarials; D011804:Quinolines; C041300:acridone