title: [The application and research advances of Brucella vaccines].
abstract: Brucellosis is a crucial zoonosis caused by Brucella, which has some traits of wide hosts, great infectivity and difficulty in cure. Brucellosis caused great losses to farming and people's health. Vaccination is the main measure used to control Brucellosis, and some attenuated Brucella strains were often used as vaccines. To find more effective vaccines, Scientists are now constructing recombinant strains, DNA vaccines and subunit vaccines, as well as inducing new attenuated strains from isolations. The present applications of B. abortus strain 19 (S19) , B. melitensis Rev. 1 (Rev. 1), B. suis strain 2 (S2), B. abortus strain 45/20 (45/20) and rough strain B. abortus 51 (RB51) were discussed. And some recent research work on Brucella vaccines, such as Brucella recombinant vaccines, DNA vaccines and so on, were reviewed in this paper.
authors.affiliation: China Institute of Veterinary Drug Control, Beijing 100081, China. dingjiabo@sohu.com
authors.forename: Jia-Bo
authors.initials: JB
authors.lastname: Ding
authors.forename: Kai-Rong
authors.initials: KR
authors.lastname: Mao
authors.forename: Jun-Sheng
authors.initials: JS
authors.lastname: Cheng
authors.forename: Zhi-Hong
authors.initials: ZH
authors.lastname: Dai
authors.forename: Yu-Wen
authors.initials: YW
authors.lastname: Jiang
mesh_terms: D000818:Animals; D002004:Brucella Vaccine / Q000276:immunology*; D006801:Humans; D011994:Recombinant Proteins / Q000276:immunology; D014613:Vaccines, Attenuated / Q000276:immunology; D019444:Vaccines, DNA / Q000276:immunology; D014614:Vaccines, Synthetic / Q000276:immunology
chemical_list: D002004:Brucella Vaccine; D011994:Recombinant Proteins; D014613:Vaccines, Attenuated; D019444:Vaccines, DNA; D014614:Vaccines, Synthetic