title: Oligoclonal T cell expansion in blood but not in the thymus from a patient with thymoma-associated pure red cell aplasia.
abstract: Despite the well-known association between thymoma and PRCA, the role of thymoma remains uncertain. There is accumulating evidence that clonal T cells are involved in acquired PRCA. We examined T cell receptor repertoires in blood and thymus from a patient with PRCA associated with thymoma and myasthenia gravis. Oligoclonal expansions of Vdelta1- and Vbeta1-expressing T cells were found in peripheral blood, whereas the repertoires of Vdelta1+ and Vbeta1+ T cells in thymoma were not skewed. Oligoclonal expansion of Vdelta1-expressing T cells remained unchanged after thymectomy. Thymus may not be the site of clonal T cell expansion in thymoma-associated PRCA.
authors.affiliation: Division of Hematology and Oncology, Department of Medicine, Akita University School of Medicine, 1-1-1 Hondo, Akita Japan. naofuji@doc.med.akita-u.ac.jp
authors.forename: Naohito
authors.initials: N
authors.lastname: Fujishima
authors.forename: Makoto
authors.initials: M
authors.lastname: Hirokawa
authors.forename: Masumi
authors.initials: M
authors.lastname: Fujishima
authors.forename: Chizu
authors.initials: C
authors.lastname: Wada
authors.forename: Itaru
authors.initials: I
authors.lastname: Toyoshima
authors.forename: Sumio
authors.initials: S
authors.lastname: Watanabe
authors.forename: Ken-ichi
authors.initials: K
authors.lastname: Sawada
mesh_terms: D002999:Clone Cells / Q000473:pathology; D016572:Cyclosporine / Q000627:therapeutic use; D005260:Female; D015333:Gene Rearrangement, beta-Chain T-Cell Antigen Receptor; D016694:Gene Rearrangement, delta-Chain T-Cell Antigen Receptor; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008875:Middle Aged; D009157:Myasthenia Gravis / Q000188:drug therapy / Q000209:etiology; D011239:Prednisolone / Q000627:therapeutic use; D012010:Red-Cell Aplasia, Pure / Q000097:blood* / Q000188:drug therapy / Q000209:etiology; D016176:T-Lymphocyte Subsets / Q000473:pathology*; D016559:Tacrolimus / Q000627:therapeutic use; D013934:Thymectomy; D013945:Thymoma / Q000097:blood* / Q000150:complications / Q000601:surgery; D013953:Thymus Neoplasms / Q000097:blood* / Q000150:complications / Q000601:surgery
chemical_list: D007166:Immunosuppressive Agents; D016572:Cyclosporine; D011239:Prednisolone; D016559:Tacrolimus