title: Two cases of subacute thyroiditis presenting in pregnancy.
abstract: Subacute thyroiditis (SAT) is an extremely rare cause of thyrotoxicosis in pregnant women. Untreated, thyrotoxicosis may result in complications, such as prematurity and congenital malformations in the fetus. We report two cases of first trimester subacute thyroiditis, one mild and one severe. The severe case, as demonstrated by laboratory and ultrasound findings, was successfully treated with prednisolone. In this case, it was thought that the benefits of pharmacological therapy outweighed the risk of potential teratogenesis by the medication. In contrast, the milder case was managed conservatively and resolved without treatment. These cases illustrate how laboratory and ultrasound findings can be used to determine whether treatment should be initiated and, once begun, if medication levels need to be adjusted. In both cases, the pregnancies resulted in healthy full-term infants.
authors.affiliation: First Department of Medicine, Osaka Medical College, Takatsuki city, Japan. in1149@poh.osaka-med.ac.jp
authors.forename: T
authors.initials: T
authors.lastname: Hiraiwa
authors.forename: S
authors.initials: S
authors.lastname: Kubota
authors.forename: A
authors.initials: A
authors.lastname: Imagawa
authors.forename: I
authors.initials: I
authors.lastname: Sasaki
authors.forename: M
authors.initials: M
authors.lastname: Ito
authors.forename: A
authors.initials: A
authors.lastname: Miyauchi
authors.forename: T
authors.initials: T
authors.lastname: Hanafusa
mesh_terms: D000328:Adult; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D011239:Prednisolone / Q000627:therapeutic use; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000188:drug therapy*; D011261:Pregnancy Trimester, First; D012720:Severity of Illness Index; D013968:Thyroiditis, Subacute / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000188:drug therapy*; D016896:Treatment Outcome; D014463:Ultrasonography
chemical_list: D005938:Glucocorticoids; D011239:Prednisolone