title: Stability of clinical and radiographic results after guided tissue regeneration in infrabony defects.
abstract: BACKGROUND
  The aim of this 5-year follow-up study was to evaluate clinically and radiographically the long-term results after guided tissue regeneration (GTR) therapy of infrabony defects using non-resorbable and bioabsorbable barriers.
  
  
  METHODS
  Thirty-one patients with periodontitis and 50 infrabony defects that had been treated using GTR were recruited. Eleven defects were treated with non-resorbable expanded polytetrafluoroethylene membranes and 39 defects with bioabsorbable barriers. At baseline and 6 and 60 +/- 3 months after surgery, clinical parameters and standardized radiographs were obtained. During surgery and 60 +/- 3 months thereafter, the distance from the cemento-enamel junction to the base of the bony defect (vertical probing bone level [PBL-V]) was measured. Bone gain was evaluated using digital subtraction radiography.
  
  
  RESULTS
  At 6 and 60 +/- 3 months after GTR, there was a statistically significant (P <0.001) reduction of probing depth (6 months: 4.31 +/- 1.76 mm; 60 months: 3.95 +/- 1.62 mm) and vertical clinical attachment level gains (CAL-V) (6 months: 3.34 +/- 1.66 mm; 60 months: 2.97 +/- 1.53 mm). From 6 to 60 months after GTR, three infrabony defects exhibited CAL-V loss >2 mm, and a small, statistically not significant mean CAL-V loss of 0.39 +/- 1.60 mm was observed. From baseline to 60 +/- 3 months, a significant PBL-V gain of 1.78 +/- 2.67 mm (P <0.001) and increase in bone density were observed (P = 0.003).
  
  
  CONCLUSIONS
  The CAL-V gain achieved after GTR in infrabony defects using both non-resorbable and bioabsorbable barriers was stable after 5 years in 47 of 50 defects.
authors.affiliation: Department of Periodontology, Center for Dental, Oral, and Maxillofacial Medicine, Hospital of Johann Wolfgang Goethe-University Frankfurt, Frankfurt am Main, Germany. eickholz@med.uni-frankfurt.de
authors.forename: Peter
authors.initials: P
authors.lastname: Eickholz
authors.forename: Diana-Maria
authors.initials: DM
authors.lastname: Krigar
authors.forename: Ti-Sun
authors.initials: TS
authors.lastname: Kim
authors.forename: Peter
authors.initials: P
authors.lastname: Reitmeir
authors.forename: Andrew
authors.initials: A
authors.lastname: Rawlinson
mesh_terms: D020341:Absorbable Implants; D000328:Adult; D016301:Alveolar Bone Loss / Q000000981:diagnostic imaging / Q000601:surgery*; D015519:Bone Density; D001861:Bone Regeneration; D005260:Female; D005500:Follow-Up Studies; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008567:Membranes, Artificial; D008875:Middle Aged; D010512:Periodontal Index; D011091:Polyesters; D011138:Polytetrafluoroethylene; D011379:Prognosis; D019252:Radiography, Dental, Digital / Q000379:methods; D012008:Recurrence; D012044:Regression Analysis; D012189:Retrospective Studies; D018709:Statistics, Nonparametric; D013382:Subtraction Technique
chemical_list: D008567:Membranes, Artificial; D011091:Polyesters; C033616:poly(lactide); D011138:Polytetrafluoroethylene