title: Increased expression of galectin-1 during the progression of cervical neoplasia.
abstract: Galectin-1, a member of the beta-galactoside-binding family, is widely expressed in epithelial and immune cells. It is involved in several normal and pathologic processes, such as cancer progression, metastasis, and immunobiology. Galectin-1 was found to be overexpressed in various cancer cells and the corresponding benign tissue. Therefore, it has been described as a marker for tumor progression in some malignancies. In the current study, the expression of galectin-1 was examined in 80 formalin-fixed, paraffin-embedded cervical tissues: 20 benign cervical specimen, 20 low-grade squamous intraepithelial lesions (LGSIL), 20 high-grade squamous intraepithelial lesions (HGSIL), and 20 invasive squamous cell carcinomas (ISCC). Immunohistochemical analyses showed that the intensity of the galectin-1 expression on stromal cells next to the transformed cells increased according to the pathologic grade: benign cervical tissue < LGSIL < HGSIL < ISCC (P < 0.001). The epithelial cells were always negative for galectin-1. These results suggest that galectin-1 expression on stromal cells increases with the histopathologic grade of cervical tissues, and it can be concluded that this increase is associated with the progression of cervical neoplasia.
authors.affiliation: Department of Obstetrics and Gynecology, University of Wuerzburg, Wuerzburg, Germany. kohrenhagen@email.de
authors.forename: N
authors.initials: N
authors.lastname: Kohrenhagen
authors.forename: H U
authors.initials: HU
authors.lastname: Volker
authors.forename: M
authors.initials: M
authors.lastname: Kapp
authors.forename: J
authors.initials: J
authors.lastname: Dietl
authors.forename: U
authors.initials: U
authors.lastname: Kammerer
mesh_terms: D018450:Disease Progression; D005260:Female; D037483:Galectin 1 / Q000378:metabolism*; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007150:Immunohistochemistry; D015854:Up-Regulation; D002583:Uterine Cervical Neoplasms / Q000378:metabolism* / Q000473:pathology*
chemical_list: D037483:Galectin 1