title: [The role of cord blood stem cell transplantation in children; a retrospective analysis of 39 cases in a single institute].
abstract: We report the results of 39 children who underwent cord blood stem cell transplantation (CBSCT) at our institute during the period from February 1996 to July 2005. The patients consisted of 9 with non-malignant disease, 26 with malignant disease and 4 with Epstein-Barr virus (EBV) associated disease. The median age of the patients was 4 years and 8 months (range, 6 months to 16 years 2 months). The median infused cell dose was 4.9 (range, 1.7-11.4) x 10(7)/kg. Thirty-four transplants were from HLA-mismatched donors, and 33 patients underwent a tacrolimus-containing regimen for GVHD prophylaxis. As for CBSCT as the first transplant, 3 out of 4 children with non-malignant disease achieved engraftment after CBSCT with the use of a reduced-intensity conditioning regimen. For acute leukemia, 3 patients out of 5 in their first remission and 2 out of 9 in advanced stage at CBSCT continue in remission at the time of writing. Fourteen patients received CBSCT as a second or a third transplant. None of 4 patients who underwent CBSCT as rescue therapy after rejection/graft failure achieved engraftment. It should be emphasized that EBV-associated disease seems to be a suitable disease for CBSCT, because all of the 4 patients who underwent CBSCT are still in CR.
authors.affiliation: Department of Pediatrics, Osaka Medical Center and Research Institute for Maternal and Child Health.
authors.forename: Masami
authors.initials: M
authors.lastname: Inoue
authors.forename: Masahiro
authors.initials: M
authors.lastname: Yasui
authors.forename: Akihisa
authors.initials: A
authors.lastname: Sawada
authors.forename: Maho
authors.initials: M
authors.lastname: Koyama
authors.forename: Akifumi
authors.initials: A
authors.lastname: Sakata
authors.forename: Yasufumi
authors.initials: Y
authors.lastname: Takeshita
authors.forename: Masahiko
authors.initials: M
authors.lastname: Kouroki
authors.forename: Takayuki
authors.initials: T
authors.lastname: Okamura
authors.forename: Naoki
authors.initials: N
authors.lastname: Sakata
authors.forename: Keisei
authors.initials: K
authors.lastname: Kawa
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D036101:Cord Blood Stem Cell Transplantation; D020031:Epstein-Barr Virus Infections / Q000628:therapy; D006801:Humans; D007223:Infant; D009369:Neoplasms / Q000628:therapy; D012189:Retrospective Studies; D016896:Treatment Outcome