CN-HMBC: a powerful NMR technique for the simultaneous detection of long-range 1H,13C and 1H,15N connectivities.
[structure: see text] A new one-shot NMR experiment (CN-HMBC) is proposed for the simultaneous acquisition of 2D 1H,13C and 1H,15N HMBC spectra. Important sensitivity enhancements (up to 41% simultaneously for both 13C and 15N) or time savings (about 50%) can be achieved when compared to the separate acquisition of individual HMBC spectra. The experiment is highly recommended for the complete structural analysis and simultaneous chemical shift assignments of protonated and nonprotonated 13C and 15N resonances in nitrogen-containing organic compounds.
Pérez-Trujillo
Miriam
M
Servei de Ressonància Magnètica Nuclear, Universitat Autonoma de Barcelona, 08193 Bellaterra, Barcelona, Spain.
Nolis
Pau
P
Parella
Teodor
T