Sulfated alkenes from the echinus Temnopleurus hardwickii.
Three new sulfated alkenes (1-3), trimethylammonium (5R)-5,9-dimethyl-(3E)-3,8-decadienyl-1-sulfate, dimethylammonium (5R)-5,9-dimethyl-(3E)-3,8-decadienyl-1-sulfate, and 2'-methyl-4'-oxobutan-2-ylammonium (5R)-5,9-dimethyl-(3E)-3,8-decadienyl-1-sulfate, were isolated from an echinoderm, Temnopleurus hardwickii. Their structures were elucidated by spectral analysis and chemical degradation methods.
Chen
Li
L
Key Laboratory of Marine Drugs, Chinese Ministry of Education, Institute of Marine Drugs and Food, Ocean University of China, Qingdao 266003, People's Republic of China.
Fang
Yuchun
Y
Luo
Xiaodong
X
He
Hongping
H
Zhu
Tianjiao
T
Liu
Hongbing
H
Gu
Qianqun
Q
Zhu
Weiming
W
D000475:Alkenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002681:China; D004354:Drug Screening Assays, Antitumor; D004447:Echinodermata / Q000737:chemistry*; D006801:Humans; D020128:Inhibitory Concentration 50; D007941:Leukemia P388; D051379:Mice; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D013463:Sulfuric Acid Esters / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
C516407:2'-methyl-4'-oxobutan-2-ylammonium(5R)-5,9-dimethyl-(3E)-3,8-decadienyl-1-sulfate; D000475:Alkenes; D000970:Antineoplastic Agents; D013463:Sulfuric Acid Esters; C516406:dimethylammonium (5R)-5,9-dimethyl-(3E)-3,8-decadienyl-1-sulfate; C516405:trimethylammonium (5R)-5,9-dimethyl-(3E)-3,8-decadienyl-1-sulfate