title: Dose-dependent immune response to Mycobacterium bovis BCG vaccination in neonates.
abstract: In 10-week-old infants vaccinated at birth with Japanese Mycobacterium bovis BCG, the number of dermal needle penetrations correlated positively with frequency of proliferating CD4(+) T cells in whole blood following BCG stimulation for 6 days but did not correlate with secreted cytokine levels after 7 h or interferon CD4(+) T-cell frequency after 12 h of BCG stimulation.
authors.affiliation: South African Tuberculosis Vaccine Initiative (SATVI), Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.
authors.forename: Virginia
authors.initials: V
authors.lastname: Davids
authors.forename: Willem
authors.initials: W
authors.lastname: Hanekom
authors.forename: Sebastian J
authors.initials: SJ
authors.lastname: Gelderbloem
authors.forename: Anthony
authors.initials: A
authors.lastname: Hawkridge
authors.forename: Gregory
authors.initials: G
authors.lastname: Hussey
authors.forename: Ronel
authors.initials: R
authors.lastname: Sheperd
authors.forename: Lesley
authors.initials: L
authors.lastname: Workman
authors.forename: Jorge
authors.initials: J
authors.lastname: Soler
authors.forename: Rose Ann
authors.initials: RA
authors.lastname: Murray
authors.forename: Stanley R
authors.initials: SR
authors.lastname: Ress
authors.forename: Gilla
authors.initials: G
authors.lastname: Kaplan
mesh_terms: D001500:BCG Vaccine / Q000276:immunology*; D004306:Dose-Response Relationship, Immunologic; D006801:Humans; D007223:Infant; D007231:Infant, Newborn / Q000276:immunology*; D014376:Tuberculosis / Q000276:immunology / Q000517:prevention & control*
chemical_list: D001500:BCG Vaccine