title: In vivo biocompatibility of sulfonated PEO-grafted polyurethanes for polymer heart valve and vascular graft.
abstract: Sulfonated poly(ethylene oxide) (PEO)-grafted polyurethane (PU) (PU-PEO-SO(3)) prepared by bulk modification was used to coat both PU heart valves and vascular grafts, and their in vivo biocompatibility was evaluated using a canine shunt method. The two devices were implanted for up to 39 days and retrieved at specific time points for the analysis of blood compatibility, biostability, and calcium deposition. When the surface of the retrieved specimens was examined using scanning electron microscopy, platelet adhesion and thrombus formation appeared to be significantly lesser formed on the PU-PEO-SO(3)-coated implants, compared with the untreated PUs. While molecular weights of untreated PUs were found by gel permeation chromatography to be decreased after 39 days from implantation, the same remained barely changed with the PU-PEO-SO(3)-coated ones. The inductively coupled plasma study indicated that the amount of deposited calcium was significantly reduced in the surface-modified PU implants. The efficacy of PU-PEO-SO(3)-coated implants in terms of blood compatibility, biostability, and calcification resistance may render them as a promising biomedical material in the application for blood/tissue-contacting tissues and organs.
authors.affiliation: Biomaterials Research Center, Korea Institute of Science and Technology, Cheongryang, Seoul, Korea. dkh@kist.re.kr
authors.forename: Dong Keun
authors.initials: DK
authors.lastname: Han
authors.forename: Kwideok
authors.initials: K
authors.lastname: Park
authors.forename: Ki Dong
authors.initials: KD
authors.lastname: Park
authors.forename: Kwang-Duk
authors.initials: KD
authors.lastname: Ahn
authors.forename: Young Ha
authors.initials: YH
authors.lastname: Kim
mesh_terms: D000818:Animals; D001807:Blood Vessel Prosthesis; D020099:Coated Materials, Biocompatible; D004285:Dogs; D006350:Heart Valve Prosthesis; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D010973:Platelet Adhesiveness; D011092:Polyethylene Glycols / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D011140:Polyurethanes / Q000737:chemistry*; D011474:Prosthesis Design; D013451:Sulfonic Acids / Q000737:chemistry*; D013499:Surface Properties; D013927:Thrombosis
chemical_list: D020099:Coated Materials, Biocompatible; D011108:Polymers; D011140:Polyurethanes; D013451:Sulfonic Acids; C426021:amino-polyethyleneoxide-sulfonate; D011092:Polyethylene Glycols