[Effect of amber acid on the kidney function in gentamycin-induced nephropathy in white rats].
The amber acid neutralized by 10 % solution of NaOH in a concentration of 250 mmoL/L was administered subcutaneously simultaneously with intraperitonal injection of gentamycin in a doze of 10 mg/kg(bw) once a day during 7 days to the ten nonlinear white male rats, weight 100-120 g exposed to the water-induced diuresis. In these experiments the positive action of an amber acid as energy substratum on some renal function tests was shown: improvement of reabsorbtion in proximal tubules, proved by proteinuria decrease, subsequent normalization of glomerular filtrations followed by uremia reduction and diminishing of other signs of acute renal failure.
Hozhenko
A I
AI
Vladymyrova
M P
MP
Topor
O A
OA
D058186:Acute Kidney Injury / Q000139:chemically induced / Q000503:physiopathology / Q000517:prevention & control*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D005839:Gentamicins / Q000009:adverse effects*; D005919:Glomerular Filtration Rate / Q000187:drug effects*; D007274:Injections, Intraperitoneal; D007279:Injections, Subcutaneous; D007677:Kidney Function Tests; D008297:Male; D051381:Rats; D019802:Succinic Acid / Q000008:administration & dosage / Q000627:therapeutic use*
D000900:Anti-Bacterial Agents; D005839:Gentamicins; D019802:Succinic Acid