title: Correlations between dynamic contrast-enhanced magnetic resonance imaging-derived measures of tumor microvasculature and interstitial fluid pressure in patients with cervical cancer.
abstract: OBJECTIVE
  To correlate permeability (rk(trans)), extracellular volume fraction (rv(e)), relative to muscle and initial area under the enhancement curve (IAUC(60m)) determined by dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) with in vivo measurements of interstitial fluid pressure (IFP) in patients with cervical cancer.
  
  
  METHODS
  DCE-MRI and IFP measurements were performed of cervical tumors of 32 patients prior to therapy. Median tumor rk(trans) and rv(e) were derived from a bidirectional two-compartment model using an input function derived from muscle. Median IAUC(60m) was defined as the integral of tumor enhancement in the first 60 seconds divided by the similar muscle enhancement integral. These parameters were correlated with the mean tumor IFP.
  
  
  RESULTS
  There was a significant negative correlation between IAUC(60m) and IFP (r = -0.42, P = 0.016) and between rk(trans) and IFP (r = -0.47, P = 0.008). The was no significant correlation between IFP and rv(e).
  
  
  CONCLUSIONS
  There is a moderate negative correlation between IAUC(60m), rk(trans), and IFP in cervical cancer. This suggests that these parameters may be of value in assessment of tumor behavior.
authors.affiliation: Department of Medical Imaging, University Health Network and Mount Sinai Hospital, University of Toronto, Ontario, Canada. m.haider@utoronto.ca
authors.forename: Masoom A
authors.initials: MA
authors.lastname: Haider
authors.forename: Igor
authors.initials: I
authors.lastname: Sitartchouk
authors.forename: Timothy P L
authors.initials: TP
authors.lastname: Roberts
authors.forename: Anthony
authors.initials: A
authors.lastname: Fyles
authors.forename: Ali T
authors.initials: AT
authors.lastname: Hashmi
authors.forename: Michael
authors.initials: M
authors.lastname: Milosevic
mesh_terms: D000328:Adult; D000368:Aged; D019540:Area Under Curve; D003287:Contrast Media; D045604:Extracellular Fluid / Q000502:physiology*; D005260:Female; D019786:Gadolinium DTPA; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008875:Middle Aged; D010539:Permeability; D011312:Pressure; D018709:Statistics, Nonparametric; D002583:Uterine Cervical Neoplasms / Q000098:blood supply* / Q000473:pathology*
chemical_list: D003287:Contrast Media; C064925:gadodiamide; D019786:Gadolinium DTPA