title: Performance of different ovarian reserve markers for predicting the numbers of oocytes retrieved and mature oocytes.
abstract: OBJECTIVE
  To assess the performance of different ovarian reserve tests for predicting the total numbers of oocytes retrieved and mature oocytes.
  
  
  METHODS
  A retrospective study was performed on 71 women undergoing their first IVF/intracytoplasmic sperm injection treatment. Basal ovarian reserve screening was performed on days 2-3 of a spontaneous cycle. Patients were down-regulated with the GnRH agonist, whereas ovarian stimulation was carried out with recombinant FSH, starting from day 2 to 3 of the cycle. The main outcome measures were the numbers of oocytes retrieved and mature oocytes.
  
  
  RESULTS
  The total number of oocytes was positively correlated with AFC (p<0.0001) and E(2) levels post-GnRH (p<0.004), whereas there was an inverse correlation with age (p<0.0001). The number of mature oocytes also correlated with AFC (p<0.008) and E(2) levels post-GnRH (p<0.009), and inversely with age (p<0.0004). Univariate linear regression of square root of number of oocytes (SQNO) shows that acceptable predictors of number oocytes, based on model significance and R(2) are AFC (R(2)=0.215), age (R(2)=0.24) and E(2) variation (R(2)=0.09). The following model is proposed to predict the number of mature oocytes: ln(MO)=ln(NO)-2.09+0.028 AGE+0.03 BMI.
  
  
  CONCLUSIONS
  The number of antral follicles and patient age appear to be good markers of ovarian response in IVF treatments. Additional information is provided by stimulated E(2) levels.
authors.affiliation: Department of General and Specialist Surgery, Gynaecology and Obstetric Unit A, University of Bari, Bari, Italy. milalorusso@yahoo.it
authors.forename: Filomenamila
authors.initials: F
authors.lastname: Lorusso
authors.forename: Mario
authors.initials: M
authors.lastname: Vicino
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Lamanna
authors.forename: Paolo
authors.initials: P
authors.lastname: Trerotoli
authors.forename: Gabriella
authors.initials: G
authors.lastname: Serio
authors.forename: Raffaella
authors.initials: R
authors.lastname: Depalo
mesh_terms: D000328:Adult; D003661:Decision Support Techniques; D005260:Female; D005307:Fertilization in Vitro; D005640:Follicle Stimulating Hormone / Q000008:administration & dosage; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists; D006801:Humans; D009865:Oocytes / Q000502:physiology*; D006080:Ovarian Follicle / Q000502:physiology*; D010062:Ovulation Induction; D011247:Pregnancy; D012189:Retrospective Studies; D020554:Sperm Injections, Intracytoplasmic
chemical_list: D007987:Gonadotropin-Releasing Hormone; D005640:Follicle Stimulating Hormone