title: The functions of RPS19 and their relationship to Diamond-Blackfan anemia: a review.
abstract: The relatively new study of ribosomal proteins has allowed for greater understanding of protein synthesis; however the connection between ribosomal proteins' roles and that of disease pathophysiology has not yet been established. RPS19 is a ribosomal protein linked to Diamond-Blackfan anemia whose functions have begun to be elucidated. We review here the known roles of RPS19 in both ribosome construction and other extra-ribosomal functions and discuss their relationship to Diamond-Blackfan anemia.
authors.affiliation: Division of Hematology/Oncology, Department of Pediatrics, UCLA Mattel Children's Hospital, CA 90095, USA. kmorimoto@mednet.ucla.edu
authors.forename: Kenji
authors.initials: K
authors.lastname: Morimoto
authors.forename: Shou
authors.initials: S
authors.lastname: Lin
authors.forename: Kathleen
authors.initials: K
authors.lastname: Sakamoto
mesh_terms: D029503:Anemia, Diamond-Blackfan / Q000235:genetics* / Q000378:metabolism; D020022:Genetic Predisposition to Disease; D006801:Humans; D012269:Ribosomal Proteins / Q000235:genetics* / Q000378:metabolism; D012270:Ribosomes / Q000235:genetics / Q000378:metabolism*
chemical_list: D012269:Ribosomal Proteins; C040343:ribosomal protein S19