title: Association between cupular deposits and otosclerosis.
abstract: OBJECTIVE
  To evaluate whether otosclerosis is an underlying mechanism for the production of cupular deposits and to study the association between cupular deposits and dysequilibrium in otosclerosis.
  
  
  METHODS
  Retrospective human temporal bone (TB) study. The incidence of cupular deposits in these 70 TBs was analyzed. Correlations between cupular deposits and vestibular symptoms, endosteal involvement of the otosclerotic focus, stapedial fixation, and clinical history of stapes surgery were evaluated.
  
  
  METHODS
  Otolaryngology laboratory in a tertiary academic medical center.
  
  
  METHODS
  The study material consisted of 35 human TBs with otosclerosis and 35 age-matched controls.
  
  
  METHODS
  Morphometric evaluations of the incidence of cupular deposits, endosteal involvement of the otosclerotic focus, and stapedial fixation were made by light microscopy. Clinical records were reviewed retrospectively for clinical history of stapes surgery and prevalence of vestibular symptoms. The incidence of cupular deposits was compared between the otosclerotic and control groups. Correlations between cupular deposits and vestibular symptoms, endosteal involvement of the otosclerotic focus, stapedial fixation, and clinical history of stapes surgery were evaluated in the subjects with otosclerosis.
  
  
  RESULTS
  The incidence of cupular deposits in TBs with otosclerosis was significantly higher than in those without whereas there was no correlation between the incidence of the deposits and dysequilibrium in cases of otosclerosis. An increase in deposits did not correlate with stapedial fixation, stapes surgery, or endosteal involvement.
  
  
  CONCLUSIONS
  Our results suggest otosclerosis as an underlying mechanism for the production of cupular deposits; however, we did not find an association between these deposits and vestibular symptoms.
authors.affiliation: Department of Otolaryngology, Otitis Media Research Center, University of Minnesota, Minneapolis, USA.
authors.forename: Hideo
authors.initials: H
authors.lastname: Hayashi
authors.forename: Sebahattin
authors.initials: S
authors.lastname: Cureoglu
authors.forename: Patricia A
authors.initials: PA
authors.lastname: Schachern
authors.forename: Mehmet F
authors.initials: MF
authors.lastname: Oktay
authors.forename: Hisaki
authors.initials: H
authors.lastname: Fukushima
authors.forename: Michihiko
authors.initials: M
authors.lastname: Sone
authors.forename: Michael M
authors.initials: MM
authors.lastname: Paparella
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001491:Basophils / Q000473:pathology*; D018450:Disease Progression; D006801:Humans; D015994:Incidence; D008875:Middle Aged; D010040:Otosclerosis / Q000150:complications / Q000453:epidemiology / Q000473:pathology*; D015995:Prevalence; D011379:Prognosis; D012189:Retrospective Studies; D012665:Semicircular Canals / Q000473:pathology*; D014717:Vertigo / Q000453:epidemiology / Q000209:etiology / Q000473:pathology