title: Effects of bladder training and/or tolterodine in female patients with overactive bladder syndrome: a prospective, randomized study.
abstract: We compared the effects of bladder training and/or tolterodine as first line treatment in female patients with overactive bladder (OAB). One hundred and thirty-nine female patients with OAB were randomized to treatment with bladder training (BT), tolterodine (To, 2 mg twice daily) or both (Co) for 12 weeks. Treatment efficacy was measured by micturition diary, urgency scores and patients' subjective assessment of their bladder condition. Mean frequency and nocturia significantly decreased in all treatment groups, declining 25.9% and 56.1%, respectively, in the BT group; 30.2% and 65.4%, respectively, in the To group; and 33.5% and 66.3%, respectively in the Co group (p<0.05 for each). The decrease in frequency was significantly greater in the Co group than in the BT group (p<0.05). Mean urgency score decreased by 44.8%, 62.2% and 60.2% in the BT, To, and Co groups, respectively, and the improvement was significantly greater in the To and Co groups than in the BT group (p<0.05 for each). Although BT, To and their combination were all effective in controlling OAB symptoms, combination therapy was more effective than either method alone. Tolterodine alone may be instituted as a first-line therapy, but may be more effective when combined with bladder training.
authors.affiliation: Department of Urology, University of Ulsan College of Medicine, Asan Medical Center, 388-1 Poongnapdong, Songpa-Gu, Seoul, Korea.
authors.forename: Cheryn
authors.initials: C
authors.lastname: Song
authors.forename: Jun Tag
authors.initials: JT
authors.lastname: Park
authors.forename: Kyeong Ok
authors.initials: KO
authors.lastname: Heo
authors.forename: Kyu Sung
authors.initials: KS
authors.lastname: Lee
authors.forename: Myung-Soo
authors.initials: MS
authors.lastname: Choo
mesh_terms: D001521:Behavior Therapy / Q000379:methods*; D001559:Benzhydryl Compounds / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D003408:Cresols / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008875:Middle Aged; D018727:Muscarinic Antagonists / Q000627:therapeutic use; D017063:Outcome Assessment, Health Care; D010665:Phenylpropanolamine / Q000627:therapeutic use*; D014039:Toilet Training; D000068737:Tolterodine Tartrate; D016896:Treatment Outcome; D053201:Urinary Bladder, Overactive / Q000628:therapy*
chemical_list: D001559:Benzhydryl Compounds; D003408:Cresols; D018727:Muscarinic Antagonists; D010665:Phenylpropanolamine; D000068737:Tolterodine Tartrate