title: The role of mitomycin C in surgery of the frontonasal recess: a prospective open pilot study.
abstract: BACKGROUND
  Mitomycin C (MMC) inhibits fibroblast proliferation. The objective of this study was to determine the efficacy of MMC in reducing frontal ostium stenosis after endoscopic sinus surgery.
  
  
  METHODS
  A prospective open pilot study was conducted in 28 patients who had undergone one or more previous surgical interventions for frontal sinusitis. MMC solution was applied to the frontal ostial region via an endoscopic or combined endoscopic and external approach. Patency of the frontal ostium was evaluated endoscopically during regular follow-up. If restenosis was observed further, endoscopic application of MMC was undertaken.
  
  
  RESULTS
  There were 17 men and 11 women (mean age, 51.7 years; range, 26-86 years). Mean number of applications was 1.5 (range, 1:3). Mean follow-up was 19 months (range, 6-32 months). Patency rate was 86%.
  
  
  CONCLUSIONS
  Mitomycin appears to have an important role in reducing postoperative scarring, which may obviate the need for repeated and more extensive surgery.
authors.affiliation: Institute of Laryngology and Otology, University College London, London, United Kingdom.
authors.forename: Kwame
authors.initials: K
authors.lastname: Amonoo-Kuofi
authors.forename: Valerie J
authors.initials: VJ
authors.lastname: Lund
authors.forename: Peter
authors.initials: P
authors.lastname: Andrews
authors.forename: David J
authors.initials: DJ
authors.lastname: Howard
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use*; D049109:Cell Proliferation / Q000187:drug effects; D003251:Constriction, Pathologic / Q000188:drug therapy / Q000473:pathology / Q000601:surgery; D004724:Endoscopy; D005260:Female; D005347:Fibroblasts / Q000187:drug effects / Q000473:pathology; D005500:Follow-Up Studies; D005626:Frontal Sinus / Q000473:pathology; D015522:Frontal Sinusitis / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000627:therapeutic use*; D013517:Otorhinolaryngologic Surgical Procedures / Q000379:methods; D010865:Pilot Projects; D011446:Prospective Studies; D016896:Treatment Outcome
chemical_list: D000903:Antibiotics, Antineoplastic; D016685:Mitomycin