title: The accuracy of the FreeStyle Navigator continuous glucose monitoring system in children with type 1 diabetes.
abstract: OBJECTIVE
  To evaluate the accuracy and precision of the FreeStyle Navigator continuous glucose monitoring system in children with type 1 diabetes.
  
  
  METHODS
  In 30 children with type 1 diabetes (mean age 11.2 +/- 4.1 years), the Navigator glucose values were compared with reference serum glucose values of blood samples obtained in an inpatient clinical research center and measured in a central laboratory using a hexokinase enzymatic method and in an outpatient setting with a FreeStyle meter. Median absolute difference (AD) and median relative absolute difference (RAD) were computed for sensor-reference and sensor-sensor pairs.
  
  
  RESULTS
  The median AD and RAD were 17 mg/dl and 12%, respectively, for 1,811 inpatient sensor-reference pairs and 20 mg/dl and 14%, respectively, for 8,639 outpatient pairs. The median RAD between two simultaneous Navigator measurements (n = 1,971) was 13%. Ninety-one percent of sensors in the inpatient setting and 81% of sensors in the outpatient setting had a median RAD < or = 20%.
  
  
  CONCLUSIONS
  The Navigator's accuracy does not yet approach the accuracy of current-generation home glucose meters, but it is sufficient to believe that the device has the potential to be an important adjunct to treatment of youth with type 1 diabetes.
authors.affiliation: DirecNet Coordinating Center, Jaeb Center for Health Research, 15310 Amberly Dr., Suite 350, Tampa, FL 33647, USA. direcnet@jaeb.org
authors.forename: Darrell M
authors.initials: DM
authors.lastname: Wilson
authors.forename: Roy W
authors.initials: RW
authors.lastname: Beck
authors.forename: William V
authors.initials: WV
authors.lastname: Tamborlane
authors.forename: Mariya J
authors.initials: MJ
authors.lastname: Dontchev
authors.forename: Craig
authors.initials: C
authors.lastname: Kollman
authors.forename: Peter
authors.initials: P
authors.lastname: Chase
authors.forename: Larry A
authors.initials: LA
authors.lastname: Fox
authors.forename: Katrina J
authors.initials: KJ
authors.lastname: Ruedy
authors.forename: Eva
authors.initials: E
authors.lastname: Tsalikian
authors.forename: Stuart A
authors.initials: SA
authors.lastname: Weinzimer
mesh_terms: D000293:Adolescent; D001786:Blood Glucose / Q000032:analysis*; D002648:Child; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000097:blood*; D005080:Exercise Test; D005260:Female; D006801:Humans; D007297:Inpatients; D008297:Male; D018670:Monitoring, Ambulatory / Q000592:standards*; D010045:Outpatients; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D001786:Blood Glucose