title: Pulmonary-renal syndrome, diffuse pulmonary hemorrhage and glomerulonephritis, associated with Wegener's granulomatosis effectively treated with early plasma exchange therapy.
abstract: We present a case of a 38-year-old Japanese man with Wegener's granulomatosis complicated with pulmonary-renal syndrome, i.e., diffuse pulmonary hemorrhage and rapidly progressive renal glomerulonephritis. As this is a life-threatening condition, we promptly initiated plasma exchange with intravenous methylprednisolone therapy. Diffuse pulmonary hemorrhage and renal failure were markedly improved. This case merits presentation because there are few clinical studies of the treatment of Wegener's granulomatosis with pulmonary-renal syndrome, particularly with pulmonary hemorrhage.
authors.affiliation: Department of Medicine, Shiga University of Medical Science, Otsu. toshiro@belle.shiga-med.ac.jp
authors.forename: Toshiro
authors.initials: T
authors.lastname: Sugimoto
authors.forename: Naoko
authors.initials: N
authors.lastname: Deji
authors.forename: Shinji
authors.initials: S
authors.lastname: Kume
authors.forename: Norihisa
authors.initials: N
authors.lastname: Osawa
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Sakaguchi
authors.forename: Keiji
authors.initials: K
authors.lastname: Isshiki
authors.forename: Daisuke
authors.initials: D
authors.lastname: Koya
authors.forename: Atsunori
authors.initials: A
authors.lastname: Kashiwagi
mesh_terms: D000328:Adult; D005921:Glomerulonephritis / Q000175:diagnosis / Q000209:etiology / Q000628:therapy*; D005938:Glucocorticoids / Q000627:therapeutic use; D014890:Granulomatosis with Polyangiitis / Q000150:complications / Q000175:diagnosis / Q000628:therapy*; D006470:Hemorrhage / Q000175:diagnosis / Q000209:etiology / Q000628:therapy*; D006801:Humans; D008171:Lung Diseases / Q000175:diagnosis / Q000209:etiology / Q000628:therapy*; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D010951:Plasma Exchange / Q000379:methods*; D013577:Syndrome
chemical_list: D005938:Glucocorticoids; D008775:Methylprednisolone