title: Fracture risk and the use of a diuretic (indapamide SR) +/- perindopril: a substudy of the Hypertension in the Very Elderly Trial (HYVET).
abstract: BACKGROUND
  The Hypertension in the Very Elderly Trial (HYVET) is a placebo controlled double blind trial of treating hypertension with indapamide Slow Release (SR) +/- perindopril in subjects over the age of 80 years. The primary endpoints are stroke (fatal and non fatal). In view of the fact that thiazide diuretics and indapamide reduce urinary calcium and may increase bone mineral density, a fracture sub study was designed to investigate whether or not the trial anti-hypertensive treatment will reduce the fracture rate in very elderly hypertensive subjects.
  
  
  METHODS
  In the trial considerable care is taken to ascertain any fractures and to identify risk factors for fracture, such as falls, co-morbidity, drug treatment, smoking and drinking habits, levels of activity, biochemical abnormalities, cardiac irregularities, impaired cognitive function and symptoms of orthostatic hypotension. POTENTIAL RESULTS: The trial is expected to provide 10,500 patient years of follow-up. Given a fracture rate of 40/1000 patient years and a 20% difference in fracture rate, the power of the sub study is 58% to detect this difference at the 5% level of significance. The corresponding power for a reduction of 25% is 78%.
  
  
  CONCLUSIONS
  The trial is well under way, expected to complete in 2009, and on target to detect, if present, the above differences in fracture rate.
authors.affiliation: Faculty of Medicine, Imperial College London, UK. c.bulpitt@Imperial.ac.uk
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Bulpitt
authors.forename: Ruth
authors.initials: R
authors.lastname: Peters
authors.forename: Jan A
authors.initials: JA
authors.lastname: Staessen
authors.forename: Lutgarde
authors.initials: L
authors.lastname: Thijs
authors.forename: Marie-Christine
authors.initials: MC
authors.lastname: De Vernejoul
authors.forename: Astrid E
authors.initials: AE
authors.lastname: Fletcher
authors.forename: Nigel S
authors.initials: NS
authors.lastname: Beckett