Science to practice: why is the liver a radiosensitive organ?
Christiansen et al irradiated rat livers in vivo; isolated rat hepatocytes in vitro; and measured hepcidin, hemojuvelin, and ferroportin-1 gene expression. They also evaluated the influence of proinflammatory cytokines (interleukin [IL]- 1beta, IL-6, and tumor necrosis factor [TNF]-alpha) on the expression of these proteins. In this issue of Radiology, Christiansen et al conclude that radiation-induced cell-cell interactions by way of the cytokines can lead to death of irradiated hepatocytes.
Stryker
John A
JA
Department of Radiology, Lancaster General Hospital, 1400 Harrisburg Pike, Lancaster, PA 17404, USA. john_stryker@hotmail.com
D000818:Animals; D002450:Cell Communication / Q000276:immunology / Q000528:radiation effects; D016207:Cytokines / Q000276:immunology*; D022781:Hepatocytes / Q000276:immunology* / Q000528:radiation effects*; D008099:Liver / Q000276:immunology* / Q000528:radiation effects*; D011829:Radiation Dosage; D011836:Radiation Tolerance / Q000276:immunology*; D051381:Rats
D016207:Cytokines