title: Synthesis and antimicrobial activities of Schiff bases derived from 5-chloro-salicylaldehyde.
abstract: A series of Schiff bases (compounds 1-26) were synthesized by reacting 5-chloro-salicylaldehyde and primary amines, 15 (compounds 2-4, 6, 7, 10, 12-17, 23, 25 and 26) of which were first reported. The chemical structures of these compounds were confirmed by means of (1)H NMR, (13)C NMR, ESI-MS and elemental analyses. The compounds were assayed for antibacterial (Bacillus subtilis, Escherichia coli, Pseudomonas fluorescence and Staphylococcus aureus) and antifungal (Aspergillus niger, Candida albicans and Trichophyton rubrum) activities by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl trtrazolium bromide) method. Among the compounds tested, (E)-4-chloro-2-((4-fluorobenzylimino)methyl)phenol (2) showed the most favorable antimicrobial activity with MICs of 45.2, 1.6, 2.8, 3.4, and 47.5 microg/mL against B. subtilis, E. coli, P. fluorescence, S. aureus and A. niger, respectively.
authors.affiliation: Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, Jiangsu 210093, People's Republic of China.
authors.forename: Lei
authors.initials: L
authors.lastname: Shi
authors.forename: Hui-Ming
authors.initials: HM
authors.lastname: Ge
authors.forename: Shu-Hua
authors.initials: SH
authors.lastname: Tan
authors.forename: Huan-Qiu
authors.initials: HQ
authors.lastname: Li
authors.forename: Yong-Chun
authors.initials: YC
authors.lastname: Song
authors.forename: Hai-Liang
authors.initials: HL
authors.lastname: Zhu
authors.forename: Ren-Xiang
authors.initials: RX
authors.lastname: Tan
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects*; D005658:Fungi / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D012545:Schiff Bases / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: C527448:5-chloro-salicylaldehyde; D000447:Aldehydes; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D012545:Schiff Bases