[Ion channels and asthenospermia].
Asthenospermia is one of the familiar causes of male infertility. Recently, more and more studies have discovered that some diseases result from gene defect and functional variation of ion channels, known as ion channelopathies. Meanwhile, it has been found that even though many diseases do not fall into the category of the ion channelopathies, some links or passages during the disease development are closely related with the malfunction of ion channels, and many drugs can prevent and cure these diseases by acting on ion channels. The relationship of sperm physiology and pathophysiology with ion channels is gradually becoming one of the hot topics in the current researches. Recent progress in the researches on the relationship between sperm motility and ion channels ( including cation channel s and anion channels) is briefly reviewed in this article.
Li
Lu
L
Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, China.
Liu
Ji-hong
JH
D000818:Animals; D053627:Asthenozoospermia / Q000503:physiopathology*; D006801:Humans; D007473:Ion Channels; D008297:Male; D051381:Rats; D013081:Sperm Motility
D007473:Ion Channels