title: The chemokine and chemokine receptor superfamilies and their molecular evolution.
abstract: The human chemokine superfamily currently includes at least 46 ligands, which bind to 18 functionally signaling G-protein-coupled receptors and two decoy or scavenger receptors. The chemokine ligands probably comprise one of the first completely known molecular superfamilies. The genomic organization of the chemokine ligand genes and a comparison of their sequences between species shows that tandem gene duplication has taken place independently in the mouse and human lineages of some chemokine families. This means that care needs to be taken when extrapolating experimental results on some chemokines from mouse to human.
authors.affiliation: Neurocrine Biosciences, Inc, Department of Molecular Medicine, 12790 El Camino Real, San Diego, CA 92130, USA. albertzlotnik@gmail.com
authors.forename: Albert
authors.initials: A
authors.lastname: Zlotnik
authors.forename: Osamu
authors.initials: O
authors.lastname: Yoshie
authors.forename: Hisayuki
authors.initials: H
authors.lastname: Nomiyama
mesh_terms: D000818:Animals; D018925:Chemokines / Q000235:genetics* / Q000378:metabolism; D002874:Chromosome Mapping; D019143:Evolution, Molecular; D020440:Gene Duplication; D006801:Humans; D008024:Ligands; D005810:Multigene Family; D019707:Receptors, Chemokine / Q000235:genetics* / Q000378:metabolism; D014161:Transduction, Genetic
chemical_list: D018925:Chemokines; D008024:Ligands; D019707:Receptors, Chemokine