title: Nodular regenerative hyperplasia is a new cause of chronic liver disease in HIV-infected patients.
abstract: OBJECTIVE
  To describe and explain the syndrome of HIV-associated cryptogenic liver disease in eight consecutive patients suffering from portal hypertension.
  
  
  METHODS
  The study was undertaken at a liver disease centre in Paris and involved eight of 97 consecutive HIV-infected patients presenting abnormal liver function tests and/or symptomatic portal hypertension of unknown origin. Serology, pathology, and liver function tests were performed.
  
  
  RESULTS
  A clear nodular architecture corresponding to nodular regenerative hyperplasia was observed in seven patients and suggested in one, based on the presence of sinusoidal dilatation in a clinical context of portal hypertension, without overt liver disease.
  
  
  CONCLUSIONS
  Nodular regenerative hyperplasia appears to be a new cause of portal hypertension in HIV-infected patients. This syndrome can be of critical importance as patients can be exposed to the significant complications of portal hypertension and to refractory ascites which may require liver transplantation.
authors.affiliation: Université Paris-Descartes, France.
authors.forename: Vincent
authors.initials: V
authors.lastname: Mallet
authors.forename: Pierre
authors.initials: P
authors.lastname: Blanchard
authors.forename: Virginie
authors.initials: V
authors.lastname: Verkarre
authors.forename: Anaïs
authors.initials: A
authors.lastname: Vallet-Pichard
authors.forename: Hélène
authors.initials: H
authors.lastname: Fontaine
authors.forename: Caroline
authors.initials: C
authors.lastname: Lascoux-Combe
authors.forename: Stanislas
authors.initials: S
authors.lastname: Pol
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D002908:Chronic Disease; D005260:Female; D020518:Focal Nodular Hyperplasia / Q000150:complications / Q000473:pathology / Q000628:therapy / Q000821:virology*; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy / Q000276:immunology; D006801:Humans; D006975:Hypertension, Portal / Q000209:etiology; D008297:Male; D008875:Middle Aged
chemical_list: D019380:Anti-HIV Agents