title: Effect of nitroglycerine on content of second messengers in myocytes of rat thoracic aorta.
abstract: We evaluated the concentration dependence and time dependence of the effect of nitroglycerine on intracellular content of cAMP, cGMP, and free Ca2+. It was shown that after norepinephrine stimulation, nitroglycerine exhibited calcium-blocking activity in lower concentrations (starting from 10(-7) M). Under conditions of experimental nitrate tolerance the dose-dependent effect of nitroglycerine on intracellular cGMP and Ca2+ was less pronounced. Calcium-blocking activity of nitroglycerine decreased most significantly upon stimulation of myocytes with norepinephrine.
authors.affiliation: Russian State Medical University, Moscow.
authors.forename: A S
authors.initials: AS
authors.lastname: Dukhanin
authors.forename: N L
authors.initials: NL
authors.lastname: Shimanovskii
mesh_terms: D000818:Animals; D001013:Aorta, Thoracic / Q000166:cytology*; D002118:Calcium / Q000378:metabolism; D000242:Cyclic AMP / Q000378:metabolism; D006152:Cyclic GMP / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D032342:Muscle Cells / Q000378:metabolism*; D005996:Nitroglycerin / Q000494:pharmacology*; D009638:Norepinephrine; D051381:Rats; D015290:Second Messenger Systems / Q000187:drug effects* / Q000502:physiology; D013997:Time Factors; D014665:Vasodilator Agents / Q000494:pharmacology*
chemical_list: D014665:Vasodilator Agents; D000242:Cyclic AMP; D005996:Nitroglycerin; D006152:Cyclic GMP; D002118:Calcium; D009638:Norepinephrine