Yaequinolones, new insecticidal antibiotics produced by Penicillium sp. FKI-2140. I. Taxonomy, fermentation, isolation and biological activity.
New nine insecticidal antibiotics designated yaequinolones were isolated from the culture broth of the fungal strain Penicillium sp. FKI-2140 by solvent extraction, centrifugal partition chromatography and HPLC. Yaequinolones showed growth inhibitory activity against brine shrimp (Artemia salina). Among them, yaequinolone F has the most potent activity with MIC value of 0.19 microg/ml.
Uchida
Ryuji
R
School of Pharmacy, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan.
Imasato
Rie
R
Yamaguchi
Yuichi
Y
Masuma
Rokuro
R
Shiomi
Kazuro
K
Tomoda
Hiroshi
H
Omura
Satoshi
S
D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D001156:Artemia / Q000187:drug effects; D005285:Fermentation; D007306:Insecticides / Q000302:isolation & purification / Q000378:metabolism* / Q000494:pharmacology*; D007814:Larva / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D010407:Penicillium / Q000145:classification* / Q000378:metabolism*; D015363:Quinolones / Q000145:classification / Q000302:isolation & purification / Q000378:metabolism* / Q000494:pharmacology*; D013172:Spores, Fungal / Q000648:ultrastructure
D000900:Anti-Bacterial Agents; D007306:Insecticides; D015363:Quinolones