title: Immediate graft function positively affects long-term outcome of renal allografts from older but not from younger donors.
abstract: There is disagreement about the impact of delayed graft function (DGF) on renal allograft outcome. This may depend on several variables including the age of the donor. We evaluated whether DGF could have different effects in recipients of kidneys from donors aged more than 60 years versus well-matched recipients of younger kidney donors. Patients were retrospectively subdivided into 3 groups. Immediate graft function (IGF), DGF without dialysis (DGF-ND), DGF requiring dialysis (DGF-D). DGF-ND and DGF-D occurred more frequently among 198 older than 198 younger donors (P = .016 and P = .044, respectively). The 5-year patient (96% vs 93%) and pure graft (96% vs 89%) survivals were significantly better in younger recipients, while the incidence of acute rejection was similar. After a mean follow-up of 66 +/- 44 months in older donor recipients, the graft survival was significantly better among IGF than patients in the DGF-ND (P = .046) or DGF-D (P = .003) groups. Instead, in younger recipients there was no difference in graft survival between IGD and DGF-ND. Only patients with DGF-D showed a significantly worse outcome. Upon multivariate analysis of older donors, their recipients, showed the pattern of graft function recovery to be the only variable associated with allograft outcome. Instead in younger donor recipients, acute rejection and time on dialysis were the main variables associated with a poor outcome. In older donor recipients, DGF was an independent variable associated with a poor graft outcome. In younger donor recipients, duration of dialysis and rejection were the most important predictors of poor graft outcomes.
authors.affiliation: Nephrology and Dialysis Unit, Ospedale Maggiore-Policlinico-Milan ITA, Milan, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Messa
authors.forename: B
authors.initials: B
authors.lastname: Brezzi
authors.forename: D
authors.initials: D
authors.lastname: Cresseri
authors.forename: L
authors.initials: L
authors.lastname: Berardinelli
authors.forename: F
authors.initials: F
authors.lastname: Poli
authors.forename: M
authors.initials: M
authors.lastname: Scalamogna
authors.forename: G
authors.initials: G
authors.lastname: Tripepi
authors.forename: C
authors.initials: C
authors.lastname: Ponticelli
mesh_terms: D000328:Adult; D000367:Age Factors; D003404:Creatinine / Q000097:blood; D006801:Humans; D016030:Kidney Transplantation / Q000473:pathology / Q000502:physiology*; D008875:Middle Aged; D011183:Postoperative Complications / Q000453:epidemiology; D012189:Retrospective Studies; D014019:Tissue Donors / Q000706:statistics & numerical data*; D016896:Treatment Outcome
chemical_list: D003404:Creatinine