title: Impact of visceral involvements and blood cell count abnormalities on survival in adult T-cell leukemia/lymphoma (ATLL).
abstract: Multiple visceral involvements and various blood cell count abnormalities are frequently manifested in adult T-cell leukemia/lymphoma (ATLL) at diagnosis. We evaluated the effects of four visceral involvement (bone marrow (BM), skin, liver, spleen) and six blood cell count abnormalities (anemia, neutrophilia, thrombocytopenia, monocytosis, eosinophilia, basophilia) on the overall survival of 168 ATLL patients. In the aggressive type, BM involvement, skin involvement and monocytosis were significantly poor prognostic factors. Furthermore, concomitant involvement of BM and additional visceral organs worsened the prognosis. These data support that multiple organ involvements represent a poor prognostic factor for ATLL and provide clinical significance for BM examinations.
authors.affiliation: Department of Molecular Medicine and Hematology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Science, Nagasaki, Japan.
authors.forename: Yumi
authors.initials: Y
authors.lastname: Takasaki
authors.forename: Masako
authors.initials: M
authors.lastname: Iwanaga
authors.forename: Kunihiro
authors.initials: K
authors.lastname: Tsukasaki
authors.forename: Miyuki
authors.initials: M
authors.lastname: Kusano
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Sugahara
authors.forename: Yasuaki
authors.initials: Y
authors.lastname: Yamada
authors.forename: Shimeru
authors.initials: S
authors.lastname: Kamihira
authors.forename: Shuichi
authors.initials: S
authors.lastname: Ikeda
authors.forename: Masao
authors.initials: M
authors.lastname: Tomonaga
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000740:Anemia / Q000150:complications / Q000175:diagnosis / Q000401:mortality / Q000473:pathology*; D001853:Bone Marrow / Q000473:pathology*; D005260:Female; D006801:Humans; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000150:complications / Q000175:diagnosis / Q000401:mortality / Q000473:pathology*; D007960:Leukocyte Disorders / Q000150:complications / Q000175:diagnosis / Q000401:mortality / Q000473:pathology*; D008099:Liver / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D012867:Skin / Q000473:pathology; D013154:Spleen / Q000473:pathology