Genetics of sarcoidosis: candidate genes and genome scans.
Human leukocyte antigen class II allele associations and T-cell receptor beta chain bias in sarcoidosis suggest a specific disease-triggering antigen exposure in a genetically susceptible host. The cause of sarcoidosis has been elusive, but genetics provides one of the few promising avenues to further our understanding. We review the association studies and genome scans used to identify the genes involved in sarcoidosis.
Iannuzzi
Michael C
MC
Division of Pulmonary, Critical Care and Sleep Medicine, Mount Sinai School of Medicine, New York, New York, USA. michael.iannuzzi@mssm.edu
Rybicki
Benjamin A
BA
D001741:Black or African American / Q000235:genetics; D000941:Antigens / Q000235:genetics*; D020869:Gene Expression Profiling; D008040:Genetic Linkage; D023281:Genomics; D006099:Granuloma / Q000235:genetics; D006680:HLA Antigens / Q000235:genetics*; D006801:Humans; D018895:Microsatellite Repeats / Q000235:genetics; D011506:Proteins / Q000235:genetics*; D012507:Sarcoidosis / Q000208:ethnology / Q000235:genetics*
D000941:Antigens; D006680:HLA Antigens; D011506:Proteins