[Plasmodium vivax malaria with clinical presentation mimicking acute type idiopathic thrombocytopenic purpura].
Causes of thrombocytopenia are diverse, and infection with plasmodia often brings about thrombocytopenia. Japan is not an endemic area of malaria infection at present and most cases are travelers to endemic areas. In some cases, initial clinical diagnoses may not be correct because of a variety of symptoms, physical findings and laboratory abnormalities. A 67-year-old female, who had traveled to South American countries 2 months before the onset of the disease, presented with a case of vivax malaria. Because of the patient's high fever, profound thrombocytopenia (1.5 x 10(4)/microl), and elevated platelet-associated IgG on admission, our initial diagnosis was acute type idiopathic thrombocytopenic purpura (ITP). However, we recognized her tertian fever and plasmodial vivax in erythrocytes 4 days later. She responded promptly to anti-parasitic therapy after diagnosis of malaria and her laboratory data also improved. Travel history is indicative of malaria infection in some cases with thrombocytopenia mimicking acute ITP.
Komoda
Minori
M
Molecular Medicine Unit Atomic Bomb Disease Institute, Nagasaki University, Graduate School of Biomedical Sciences.
Fujimoto
Takeshi
T
Kawaguchi
Yasuhisa
Y
Tsushima
Hideki
H
Fukushima
Takuya
T
Hata
Tomoko
T
Miyazaki
Yasushi
Y
Tsukasaki
Kunihiro
K
Tomonaga
Masao
M
D000208:Acute Disease; D000368:Aged; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D016780:Malaria, Vivax / Q000175:diagnosis*; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000175:diagnosis*; D013020:South America; D014195:Travel