title: Altered glycosylation of acetylcholinesterase in the Creutzfeldt-Jakob cerebrospinal fluid.
abstract: Several neurodegenerative disorders present deficiencies in the cholinergic system. Scarce research on prion encephalopathies has examined the levels of cholinergic pathway-related enzymes. Acetylcholinesterase (AChE) is expressed as several molecular forms. The potential importance of these variants is increased by the possibility that AChE has roles other than acetylcholine hydrolysis. We investigated the levels of AChE, its molecular forms, and glycosylation in the cerebrospinal fluid (CSF) from Creutzfeldt-Jakob disease (CJD) patients.
authors.affiliation: Instituto de Neurociencias de Alicante, Universidad Miguel Hernández-CSIC, San Juan de Alicante, Spain.
authors.forename: Maria-Ximena
authors.initials: MX
authors.lastname: Silveyra
authors.forename: Maria-Salud
authors.initials: MS
authors.lastname: García-Ayllón
authors.forename: Miguel
authors.initials: M
authors.lastname: Calero
authors.forename: Javier
authors.initials: J
authors.lastname: Sáez-Valero
mesh_terms: D000110:Acetylcholinesterase / Q000134:cerebrospinal fluid*; D007562:Creutzfeldt-Jakob Syndrome / Q000134:cerebrospinal fluid* / Q000201:enzymology; D006031:Glycosylation; D006801:Humans; D012016:Reference Values
chemical_list: D000110:Acetylcholinesterase