Reproducibility and reliability of atherosclerotic plaque volume measurements in peripheral arterial disease with cardiovascular magnetic resonance.
A high resolution, noninvasive approach to quantify atherosclerotic plaque in the peripheral vasculature could have significant clinical and research utility. Seventeen patients with peripheral arterial disease (PAD) were studied in a 1.5T CMR scanner. Atherosclerotic plaque volume in the superficial femoral artery was measured and interobserver, intraobserver, and test-retest variability determined. Nineteen vessels were studied with mean acquisition time of 13.1 minutes per vessel. Mean plaque volume was 7.27 +/- 3.73 cm3. Intra-observer intraclass correlation was R = 0.997, inter-observer was R = 0.987, and test-retest reproducibility was R = 0.996. Thus, high resolution measurement of plaque volume in PAD is reliable and reproducible.
Isbell
David C
DC
Department of Medicine, University of Virginia Health System, Charlottesville, Virginia 22908, USA.
Meyer
Craig H
CH
Rogers
Walter J
WJ
Epstein
Frederick H
FH
DiMaria
Joseph M
JM
Harthun
Nancy L
NL
Wang
Hongkun
H
Kramer
Christopher M
CM
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D005240:Feasibility Studies; D005260:Female; D005263:Femoral Artery; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007383:Intermittent Claudication / Q000473:pathology*; D007866:Leg / Q000098:blood supply; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D015588:Observer Variation; D015203:Reproducibility of Results