title: Family history of hematopoietic malignancies and risk of non-Hodgkin lymphoma (NHL): a pooled analysis of 10 211 cases and 11 905 controls from the International Lymphoma Epidemiology Consortium (InterLymph).
abstract: A role for genetic susceptibility in non-Hodgkin lymphoma (NHL) is supported by the accumulating evidence of common genetic variations altering NHL risk. However, the pattern of NHL heritability remains poorly understood. We conducted a pooled analysis of 10 211 NHL cases and 11 905 controls from the International Lymphoma Epidemiology Consortium (InterLymph) to evaluate NHL risk among those with hematopoietic malignancies in first-degree relatives. Odds ratios (ORs) and 95% confidence intervals (CIs) of NHL and its subtypes were estimated from unconditional logistic regression models with adjustment for confounders. NHL risk was elevated for individuals who reported first-degree relatives with NHL (OR = 1.5; 95% CI = 1.2-1.9), Hodgkin lymphoma (OR = 1.6; 95% CI = 1.1-2.3), and leukemia (OR = 1.4; 95% CI = 1.2-2.7). Risk was highest among individuals who reported a brother with NHL (OR = 2.8; 95% CI = 1.6-4.8) and was consistent for all NHL subtypes evaluated. If a first-degree relative had Hodgkin lymphoma, NHL risk was highest if the relative was a parent (OR = 1.7; 95% CI = 1.0-2.9). If a first-degree relative had leukemia, NHL risk was highest among women who reported a sister with leukemia (OR = 3.0; 95% CI = 1.6-5.6). The pattern of NHL heritability appeared to be uniform across NHL subtypes, but risk patterns differed by specific hematopoietic malignancies and the sex of the relative, revealing critical clues to disease etiology.
authors.affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Boulevard, Bethesda, MD 20892, USA. wangso@mail.nih.gov
authors.forename: Sophia S
authors.initials: SS
authors.lastname: Wang
authors.forename: Susan L
authors.initials: SL
authors.lastname: Slager
authors.forename: Paul
authors.initials: P
authors.lastname: Brennan
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Holly
authors.forename: Silvia
authors.initials: S
authors.lastname: De Sanjose
authors.forename: Leslie
authors.initials: L
authors.lastname: Bernstein
authors.forename: Paolo
authors.initials: P
authors.lastname: Boffetta
authors.forename: James R
authors.initials: JR
authors.lastname: Cerhan
authors.forename: Marc
authors.initials: M
authors.lastname: Maynadie
authors.forename: John J
authors.initials: JJ
authors.lastname: Spinelli
authors.forename: Brian C H
authors.initials: BC
authors.lastname: Chiu
authors.forename: Pier Luigi
authors.initials: PL
authors.lastname: Cocco
authors.forename: Fiona
authors.initials: F
authors.lastname: Mensah
authors.forename: Yawei
authors.initials: Y
authors.lastname: Zhang
authors.forename: Alexandra
authors.initials: A
authors.lastname: Nieters
authors.forename: Luigino
authors.initials: L
authors.lastname: Dal Maso
authors.forename: Paige M
authors.initials: PM
authors.lastname: Bracci
authors.forename: Adele Seniori
authors.initials: AS
authors.lastname: Costantini
authors.forename: Paolo
authors.initials: P
authors.lastname: Vineis
authors.forename: Richard K
authors.initials: RK
authors.lastname: Severson
authors.forename: Eve
authors.initials: E
authors.lastname: Roman
authors.forename: Wendy
authors.initials: W
authors.lastname: Cozen
authors.forename: Dennis
authors.initials: D
authors.lastname: Weisenburger
authors.forename: Scott
authors.initials: S
authors.lastname: Davis
authors.forename: Silvia
authors.initials: S
authors.lastname: Franceschi
authors.forename: Carlo
authors.initials: C
authors.lastname: La Vecchia
authors.forename: Lenka
authors.initials: L
authors.lastname: Foretova
authors.forename: Nikolaus
authors.initials: N
authors.lastname: Becker
authors.forename: Anthony
authors.initials: A
authors.lastname: Staines
authors.forename: Martine
authors.initials: M
authors.lastname: Vornanen
authors.forename: Tongzhang
authors.initials: T
authors.lastname: Zheng
authors.forename: Patricia
authors.initials: P
authors.lastname: Hartge
mesh_terms: D016022:Case-Control Studies; D035061:Control Groups; D005190:Family; D005260:Female; D019337:Hematologic Neoplasms / Q000453:epidemiology / Q000209:etiology / Q000235:genetics; D006801:Humans; D007391:International Cooperation; D016015:Logistic Models; D008228:Lymphoma, Non-Hodgkin / Q000453:epidemiology / Q000209:etiology / Q000235:genetics; D008297:Male; D010375:Pedigree; D012307:Risk Factors; D012737:Sex Factors