title: A fluorous, Pummerer cyclative-capture strategy for the synthesis of N-heterocycles.
abstract: A fluorous, cyclative-capture strategy based on a new Pummerer cyclization process allows rapid access to tagged, heterocyclic frameworks. Convenient modification of the fluorous, heterocyclic scaffolds by using a variety of approaches including Pd-catalyzed cross-couplings is possible. Traceless, reductive cleavage of the fluorous-phase tag or oxidative cleavage and further elaboration, completes a strategy for the high-throughput, fluorous-phase synthesis of a diverse range of N-heterocycles.
authors.affiliation: Department of Chemistry, The Joseph Black Building, The University of Glasgow, Glasgow G12 8QQ, Scotland.
authors.forename: Laura A
authors.initials: LA
authors.lastname: McAllister
authors.forename: Rosemary A
authors.initials: RA
authors.lastname: McCormick
authors.forename: Karen M
authors.initials: KM
authors.lastname: James
authors.forename: Stephen
authors.initials: S
authors.lastname: Brand
authors.forename: Nigel
authors.initials: N
authors.lastname: Willetts
authors.forename: David J
authors.initials: DJ
authors.lastname: Procter
mesh_terms: D003500:Cyclization; D005459:Fluorides / Q000737:chemistry*; D006571:Heterocyclic Compounds / Q000138:chemical synthesis*; D015394:Molecular Structure
chemical_list: D006571:Heterocyclic Compounds; D005459:Fluorides