The ins and outs of MHC class II proteins in dendritic cells.
One more mechanism for regulating surface expression of MHC class II proteins in dendritic cells (an important process that regulates both tolerance and immunity) has been uncovered, polyubiquitination of Lys225 in the intracytoplasmic region and subsequent endocytosis and proteolysis (Omura-Hoshino et al., 2006; van Neil et al., 2006; Shin et al., 2006).
Santambrogio
Laura
L
Department of Pathology, Albert Einstein College of Medicine, New York, New York 10461, USA.
Strominger
Jack L
JL
D000818:Animals; D003713:Dendritic Cells / Q000276:immunology* / Q000378:metabolism; D000949:Histocompatibility Antigens Class II / Q000276:immunology* / Q000378:metabolism*; D006801:Humans; D025801:Ubiquitin / Q000378:metabolism
D000949:Histocompatibility Antigens Class II; D025801:Ubiquitin