[Drug binding to blood proteins: characteristics, roles and pathophysiological changes].
HSA and AGP are the only plasma proteins capable of binding drugs through specific sites with high affinity. As such, they can limit drug distribution and, sometimes, drug elimination. Such binding is called restrictive. Low binding capacities are said to be permissive, as they do not lead to drug retention. Modifications of restrictive binding can influence other pharmacokinetic parameters and also have clinical implications.
Tillement
Jean-Paul
JP
Unité Fonctionnelle de Pharmacologie et Toxicologie, CHIC, 40 Avenue de Verdun, F-94010 Creteil. jpmtillement@hotmail.com
Duché
Jean-Claude
JC
Barré
Jérôme
J
D001798:Blood Proteins / Q000378:metabolism*; D006801:Humans; D008074:Lipoproteins / Q000378:metabolism; D009961:Orosomucoid / Q000378:metabolism; D004364:Pharmaceutical Preparations / Q000097:blood / Q000378:metabolism*; D010599:Pharmacokinetics; D011485:Protein Binding; D012709:Serum Albumin / Q000378:metabolism
D001798:Blood Proteins; D008074:Lipoproteins; D009961:Orosomucoid; D004364:Pharmaceutical Preparations; D012709:Serum Albumin