title: Bilateral primary choroidal melanoma treated with bilateral plaque radiotherapy: a report of three cases.
abstract: OBJECTIVE
  To report three cases of bilateral primary choroidal melanoma treated with bilateral plaque radiotherapy.
  
  
  METHODS
  Retrospective, single-center case series.
  
  
  RESULTS
  Case 1: In 1981, a 50-year-old man was diagnosed with a 5-mm-thick choroidal melanoma in the right eye (OD) and treated with plaque radiotherapy. In 1994, a 6.8-mm-thick choroidal melanoma in the left eye (OS) was treated with plaque radiotherapy. Final visual acuity was light perception OD and 20/20 OS at 24 years follow-up. Case 2: In 1983, a 53-year-old woman was diagnosed with a 3.5-mm-thick choroidal melanoma OS and treated with plaque radiotherapy. In 2001, an enlarging 2.5-mm-thick choroidal melanoma OD was treated with plaque radiotherapy. Final visual acuity was 20/30 OD and 20/20 OS at 22 years follow-up. Case 3: In 2001, a 92-year-old man was diagnosed with a 7.9-mm-thick choroidal melanoma OD treated with plaque radiotherapy. In 2003, an enlarging 2.8-mm-thick juxtapapillary choroidal melanoma was treated with plaque radiotherapy. Final visual acuity was 20/70 OD and 20/60 OS at 2.5 years follow-up. No patient showed ocular melanocytosis. Stable tumor regression was achieved in all six eyes. Metastatic disease did not develop in any case over 16 years of follow-up.
  
  
  CONCLUSIONS
  Monitoring of both eyes of patients with uveal melanoma is important for the remote possibility of melanoma in the second eye. In these three patients, plaque radiotherapy allowed for preservation of the globes and some vision.
authors.affiliation: Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA 19107, USA. carol.shields@shieldsoncology.com
authors.forename: M
authors.initials: M
authors.lastname: Furuta
authors.forename: C L
authors.initials: CL
authors.lastname: Shields
authors.forename: L
authors.initials: L
authors.lastname: Shields
authors.forename: Y
authors.initials: Y
authors.lastname: Uysal
authors.forename: J A
authors.initials: JA
authors.lastname: Shields
mesh_terms: D000369:Aged, 80 and over; D001918:Brachytherapy; D002830:Choroid Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use*; D008297:Male; D008545:Melanoma / Q000473:pathology / Q000532:radiotherapy*; D008875:Middle Aged; D012189:Retrospective Studies; D014792:Visual Acuity
chemical_list: D007457:Iodine Radioisotopes