title: Clinico-immunologic aspects of botulinum toxin type B treatment of cervical dystonia.
abstract: In this multicenter study of 100 patients with cervical dystonia, we examined the immunogenicity of botulinum toxin type B (BTX-B) and correlated the clinical response with the presence of blocking antibodies (Abs) using a novel mouse protection assay. One-third of the patients who were negative for BTX-B Abs at baseline became positive for BTX-B Abs at last visit. Thus, the high antigenicity of BTX-B limits its long-term efficacy.
authors.affiliation: Parkinson's Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, 6550 Fannin, Suite 1801, Houston, TX 77030, USA. josephj@bcm.tmc.edu
authors.forename: J
authors.initials: J
authors.lastname: Jankovic
authors.forename: C
authors.initials: C
authors.lastname: Hunter
authors.forename: B Z
authors.initials: BZ
authors.lastname: Dolimbek
authors.forename: G S
authors.initials: GS
authors.lastname: Dolimbek
authors.forename: C H
authors.initials: CH
authors.lastname: Adler
authors.forename: A
authors.initials: A
authors.lastname: Brashear
authors.forename: C L
authors.initials: CL
authors.lastname: Comella
authors.forename: M
authors.initials: M
authors.lastname: Gordon
authors.forename: D E
authors.initials: DE
authors.lastname: Riley
authors.forename: K
authors.initials: K
authors.lastname: Sethi
authors.forename: C
authors.initials: C
authors.lastname: Singer
authors.forename: M
authors.initials: M
authors.lastname: Stacy
authors.forename: D
authors.initials: D
authors.lastname: Tarsy
authors.forename: M Z
authors.initials: MZ
authors.lastname: Atassi
mesh_terms: D001905:Botulinum Toxins / Q000276:immunology* / Q000627:therapeutic use*; D019274:Botulinum Toxins, Type A; D004351:Drug Resistance / Q000187:drug effects / Q000276:immunology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009465:Neuromuscular Agents / Q000276:immunology / Q000627:therapeutic use; D014103:Torticollis / Q000188:drug therapy* / Q000276:immunology*; D014481:United States
chemical_list: D009465:Neuromuscular Agents; C096323:rimabotulinumtoxinB; D001905:Botulinum Toxins; D019274:Botulinum Toxins, Type A