title: Vitreous levels of interleukin-8 in patients with proliferative diabetic retinopathy.
abstract: OBJECTIVE
  To determine the levels of interleukin 8 (IL-8) in the vitreous of patients with proliferative diabetic retinopathy (PDR).
  
  
  METHODS
  Observational case-control study.
  
  
  METHODS
  Vitreous fluid samples were obtained by vitreoretinal surgery from 71 eyes of patients with diabetes mellitus type 2 with PDR and from 17 eyes of nondiabetic patients with a macular hole. PDR was classified as active and inactive and subdivided according to the extent of large-vessel gliotic obliteration. The cytokine levels were measured by cytometric bead array method.
  
  
  RESULTS
  The vitreous levels of IL-8 were significantly higher in patients with PDR in comparison with the control subjects (P < .001) and in patients with higher extent of large vessel gliotic obliteration (P < .001). A vitreous level of IL-8 was not associated with the presence of active PDR.
  
  
  CONCLUSIONS
  Increased levels of IL-8 in PDR were associated with a higher extent of large-vessel gliotic obliteration.
authors.affiliation: University Eye Clinic, Medical Centre Ljubljana, Zaloska 29a, 1000 Ljubljana, Slovenia. ngpetrovic@yahoo.com
authors.forename: Mojca Globocnik
authors.initials: MG
authors.lastname: Petrovic
authors.forename: Peter
authors.initials: P
authors.lastname: Korosec
authors.forename: Mitja
authors.initials: M
authors.lastname: Kosnik
authors.forename: Marko
authors.initials: M
authors.lastname: Hawlina
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000378:metabolism; D003930:Diabetic Retinopathy / Q000209:etiology / Q000378:metabolism*; D005911:Gliosis / Q000378:metabolism; D006801:Humans; D016209:Interleukin-8 / Q000378:metabolism*; D008875:Middle Aged; D015861:Retinal Neovascularization / Q000209:etiology / Q000378:metabolism; D014822:Vitreous Body / Q000378:metabolism*
chemical_list: D016209:Interleukin-8