title: Noradrenergic control of emotion-induced amnesia and hypermnesia.
abstract: Emotional memory encoding is associated with retrograde and anterograde episodic memory changes involving amnesia and hypermnesia, respectively. These effects are noradrenergic-dependent and reflect an interaction with emotional arousal and valence. Whereas anterograde amnesic effects most likely result from attentional capture by emotional arousal, retrograde amnesic and hypermnesic effects may reflect a valence-dependent filter mechanism that operates during emotional memory encoding and controls episodic memory access based upon behavioral significance. This filter mechanism may originnate in amygdala-hippocampal interactions that are modulated by both ascending locus coeruleus and descending prefrontal cortex inputs.
authors.affiliation: Department of Psychiatry, University of Bonn, Bonn, Germany. renehurlemann@gmx.de
authors.forename: René
authors.initials: R
authors.lastname: Hurlemann
mesh_terms: D000647:Amnesia / Q000503:physiopathology*; D000818:Animals; D001921:Brain / Q000502:physiology*; D004644:Emotions / Q000502:physiology*; D006801:Humans; D008568:Memory / Q000502:physiology*; D008959:Models, Neurological; D009638:Norepinephrine / Q000378:metabolism*
chemical_list: D009638:Norepinephrine