Chemotherapy of leishmaniasis Part VI: synthesis and bioevaluation of some novel terpenyl S,N- and N,N-acetals.
Some novel terpene based oxoketene S,N-acetals 2(a-g) and N,N-acetals 3(a-c) have been synthesized from oxoketene dithioacetal 1. The compounds were screened for their in vivo antileishmanial activity. Some of the compounds showed 50-70% inhibition in the hamster model.
Suryawanshi
S N
SN
Division of Medicinal Chemistry, Central Drug Research Institute, Chatter Manzil, Lucknow 226001, Uttar Pradesh, India. shivajins@yahoo.co.in
Pandey
Susmita
S
Rashmirathi
Bhatt
B A
BA
Gupta
Suman
S
D000080:Acetals / Q000138:chemical synthesis / Q000627:therapeutic use*; D000818:Animals; D000981:Antiprotozoal Agents / Q000138:chemical synthesis / Q000627:therapeutic use*; D006224:Cricetinae; D004195:Disease Models, Animal; D007893:Leishmania donovani / Q000187:drug effects*; D007896:Leishmaniasis / Q000188:drug therapy*; D008297:Male; D015394:Molecular Structure; D021261:Parasitic Sensitivity Tests; D013729:Terpenes / Q000138:chemical synthesis / Q000627:therapeutic use*
D000080:Acetals; D000981:Antiprotozoal Agents; D013729:Terpenes