The prospective preventative HIV vaccine based on modified poliovirus.
In order to control HIV pandemic, many vaccines are invented. Although none first verified its efficacy in clinic, we hypothesize that HIV vaccine based on poliovirus is potential to develop the promising one, because it can elicit the broad immune response including the main mucosal, humoral and cellular reaction. However, the viral neural virulence is one major concern. The attenuated Sabin strain is a better candidate. While partial poliovirus genes are replaced by HIV antigen genes, the defective interfering particle will fail to produce progeny virions, which may further ensure its security. Although the vaccinal immune efficacy was verified in some similar animal experiments based on poliovirus to express the exogenous genes, more animal and clinical immune trials about HIV-poliovirus chimeric minireplicons are to be carried out and the hypotheses are to be validated.
Zhang
Yang-de
YD
Institute of Biomedical Engineering, Central South University, Xiangya Road, Kai-Fu District, Changsha, Hunan 410008, PR China. z_y_de@yahoo.com.cn
Lu
Xiao-lin
XL
Li
Nian-feng
NF
D016915:AIDS Vaccines / Q000008:administration & dosage / Q000235:genetics / Q000276:immunology*; D000163:Acquired Immunodeficiency Syndrome / Q000517:prevention & control*; D000818:Animals; D000917:Antibody Formation / Q000276:immunology; D005814:Genes, Viral; D005822:Genetic Vectors; D015488:HIV Antigens / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D006801:Humans; D007111:Immunity, Cellular / Q000276:immunology; D018928:Immunity, Mucosal / Q000276:immunology; D018448:Models, Immunological; D017955:Poliovirus / Q000235:genetics / Q000276:immunology / Q000472:pathogenicity*; D014774:Virulence
D016915:AIDS Vaccines; D015488:HIV Antigens