title: High-throughput genomic technology in research and clinical management of breast cancer. Plasma-based proteomics in early detection and therapy.
abstract: Protein-based breast cancer biomarkers are a promising resource for breast cancer detection at the earliest and most treatable stages of the disease. Plasma is well suited to proteomic-based methods of biomarker discovery because it is easily obtained, is routinely used in the diagnosis of many diseases, and has a rich proteome. However, due to the vast dynamic range in protein concentration and the often uncertain tissue and cellular origin of plasma proteins, proteomic analysis of plasma requires special consideration compared with tissue and cultured cells. This review briefly touches on the search for plasma-based protein biomarkers for the early detection and treatment of breast cancer.
authors.affiliation: Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.
authors.forename: Michael A
authors.initials: MA
authors.lastname: Davis
authors.forename: Samir
authors.initials: S
authors.lastname: Hanash
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood*; D001798:Blood Proteins / Q000032:analysis; D001943:Breast Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000235:genetics / Q000628:therapy*; D042241:Early Diagnosis; D005260:Female; D023281:Genomics; D006801:Humans; D046228:Microarray Analysis; D040901:Proteomics
chemical_list: D014408:Biomarkers, Tumor; D001798:Blood Proteins