Effects of caffeine on electrophysiological and neuropsychological indices after sleep deprivation.
Caffeine is regarded as a central nervous system (CNS) stimulant. The goal of this study was to analyze electrophysiological, motor, cognitive and behavioral changes produced by caffeine ingestion after sleep deprivation. Ten subjects were evaluated after sleep deprivation, comparing the ingestion of either 400 mg of caffeine or placebo, in a double-blind randomized study. The variables analyzed were: quantitative EEG, the event-related potential (ERP-P300) and cognitive responses. The most significant quantitative EEG results, which were characterized by moment x treatment interactions, were seen in alpha and theta relative power variables. A significant decrease in relative alpha and theta was observed in the caffeine group after sleep deprivation. In relation to caffeine stimulant effects, there were no significant differences in the other parameters.
Deslandes
Andréa
A
Setor de Mapeamento Cerebral e Integração Sensório-Motora, Instituto de Psiquiatria, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ 22793-395, Brazil. andreadeslandes@uol.com.br
Ferreira
Camila
C
Veiga
Heloisa
H
Cagy
Maurício
M
Piedade
Roberto
R
Pompeu
Fernando
F
Ribeiro
Pedro
P
D000328:Adult; D000339:Affect / Q000187:drug effects; D000704:Analysis of Variance; D001931:Brain Mapping; D002110:Caffeine / Q000627:therapeutic use*; D000697:Central Nervous System Stimulants / Q000627:therapeutic use*; D003071:Cognition / Q000187:drug effects*; D004311:Double-Blind Method; D004569:Electroencephalography / Q000379:methods; D018913:Event-Related Potentials, P300 / Q000187:drug effects*; D005260:Female; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D011930:Reaction Time / Q000187:drug effects; D012892:Sleep Deprivation / Q000188:drug therapy* / Q000503:physiopathology*
D000697:Central Nervous System Stimulants; D002110:Caffeine