title: [Modification of novel oxazolidinone derivatives at C-5 side chain and their antibacterial activities].
abstract: OBJECTIVE
  To modify the C-5 side chains of the oxazolidinone derivatives and evaluate their in vitro antibacterial activities preliminarily.
  
  
  METHODS
  The title compounds were synthesized in 9 - 12 steps with the starting material 3-fluoroaniline and their in vitro antibacterial activities were examined by using Mueller-Hinton broth dilution method.
  
  
  RESULTS
  Thirty new compounds were designed and synthesized, in which eighteen novel title compounds were prepared and their structures were confirmed by 1H NMR and ESI-MS. Eleven compounds showed antibacterial activities to a certain extent, among them compounds 7a, 9a and 11a displayed promising activity.
  
  
  CONCLUSIONS
  Compounds 7a, 9a and 11a were worth further studying.
authors.affiliation: School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Zhai
authors.forename: Guo-Gang
authors.initials: GG
authors.lastname: Zhang
authors.forename: Dong-Hui
authors.initials: DH
authors.lastname: Gou
authors.forename: Jun-Peng
authors.initials: JP
authors.lastname: Liu
authors.forename: Ping
authors.initials: P
authors.lastname: Gong
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D023303:Oxazolidinones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D023303:Oxazolidinones