Metabolic modelling and the closed-loop insulin delivery problem.
The approach used by Medtronic MiniMed to close the insulin delivery loop using the subcutaneous site for both glucose sensing and insulin delivery relies on modeling insulin action and beta-cell insulin secretion. This approach is contrasted with traditional control systems engineering.
Steil
Garry
G
Medtronic MiniMed, Northridge, CA 91325, USA. garry.steil@medtronic.com
Rebrin
Kerstin
K
Mastrototaro
John J
JJ
D001786:Blood Glucose / Q000032:analysis; D006801:Humans; D007332:Insulin Infusion Systems; D050417:Insulin-Secreting Cells / Q000378:metabolism; D008954:Models, Biological
D001786:Blood Glucose