Exercise improves albumin fractional synthetic rate in chronic hemodialysis patients.
OBJECTIVE
To determine whether exercise augments the improvements in fractional synthetic rate (FSR) of albumin observed with nutrition alone.


METHODS
Randomized crossover study. Each patient randomly participated in two protein metabolism kinetic studies using primed-constant infusion of (13C) leucine 2 h before, during and 2 h after hemodialysis. Plasma enrichments of (13C) leucine and (13C) ketoisocaproate were examined to determine the FSR of albumin.


METHODS
General Clinical Research Center at Vanderbilt University Medical Center.


METHODS
Five chronic hemodialysis (CHD) patients.


METHODS
Intra-dialytic parenteral nutrition (IDPN) with or without exercise.


RESULTS
Exercise performance during hemodialysis significantly improves the FSR of albumin beyond what is observed with IDPN alone (26.2+/-3.1% per day versus 17.7+/-1.9% per day, P<0.05).


CONCLUSIONS
Exercise improves albumin fractional synthetic rate beyond what is observed with IDPN alone in the acute setting in CHD patients.
Pupim
L B
LB
Department of Medicine, Division of Nephrology, Vanderbilt University School of Medicine, Nashville, TN, USA.
Flakoll
P J
PJ
Ikizler
T A
TA
D000418:Albumins / Q000378:metabolism; D002208:Caproates / Q000493:pharmacokinetics*; D002247:Carbon Isotopes; D018592:Cross-Over Studies; D015444:Exercise / Q000502:physiology*; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000628:therapy*; D007930:Leucine / Q000493:pharmacokinetics*; D008297:Male; D008875:Middle Aged; D010288:Parenteral Nutrition; D006435:Renal Dialysis; D012709:Serum Albumin / Q000032:analysis*
D000418:Albumins; D002208:Caproates; D002247:Carbon Isotopes; D012709:Serum Albumin; D007930:Leucine