Antiviral activity of nucleoside analogues against SARS-coronavirus (SARS-coV).
The recent outbreak of severe acute respiratory syndrome (SARS), which is an acute respiratory illness, is caused by newly discovered SARS coronavirus (SARS-CoV). Herein we describe the antiviral activity of several classes of nucleoside analogues evaluated against SARS-CoV in Vero 76 cells, some of which exhibited moderate activity.
Chu
Chung K
CK
The University of Georgia, College of Pharmacy, Athens, GA, USA. dchu@rx.uga.edu
Gadthula
Srinivas
S
Chen
Xin
X
Choo
Hyunah
H
Olgen
Sureyya
S
Barnard
Dale L
DL
Sidwell
Robert W
RW
D000818:Animals; D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology*; D002522:Chlorocebus aethiops; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009705:Nucleosides / Q000737:chemistry / Q000494:pharmacology*; D045473:Severe acute respiratory syndrome-related coronavirus / Q000187:drug effects*; D013329:Structure-Activity Relationship; D014709:Vero Cells; D014779:Virus Replication / Q000187:drug effects
D000998:Antiviral Agents; D009705:Nucleosides