Morphology, mechanisms and pathology of musculoskeletal ageing.
In general terms, the recognized alterations in circulating humoral factors (hormones, cytokines, growth factors) that occur in ageing, coupled with innate cellular senescence exaggerated by the slow turnover of many connective tissue cell populations and the age-associated alterations in matrix molecule cross-linking, predispose the elderly to altered connective tissue biology. These changes can be profound, leading to poor mobility, altered ability to withstand cold, weakness and an increased risk of falls, fractures and age-associated 'degenerative' diseases, such as osteoarthritis and osteoporosis. As understanding of the causes of altered connective tissue function with age increases, it is becoming clearer that many of the predisposing factors (growth hormone, cytokines, load/life style) are potential targets for improving quality of life in the elderly.
Freemont
A J
AJ
Division of Regenerative Medicine, The Medical School, The University of Manchester, Oxford Road, Manchester M13 9PT, UK. tony.freemont@manchester.ac.uk
Hoyland
J A
JA
D053687:Adult Stem Cells / Q000502:physiology; D000375:Aging / Q000473:pathology / Q000502:physiology*; D017209:Apoptosis / Q000502:physiology; D001842:Bone and Bones / Q000502:physiology; D002358:Cartilage, Articular / Q000502:physiology; D016922:Cellular Senescence / Q000502:physiology; D003094:Collagen / Q000502:physiology; D003238:Connective Tissue / Q000473:pathology / Q000502:physiology*; D016207:Cytokines / Q000502:physiology; D012739:Gonadal Steroid Hormones / Q000502:physiology; D019382:Human Growth Hormone / Q000502:physiology; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000502:physiology; D007511:Ischemia / Q000503:physiopathology; D018482:Muscle, Skeletal / Q000502:physiology; D009142:Musculoskeletal Physiological Phenomena; D011509:Proteoglycans / Q000502:physiology; D013314:Stress, Mechanical
D016207:Cytokines; D012739:Gonadal Steroid Hormones; D011509:Proteoglycans; D019382:Human Growth Hormone; D007334:Insulin-Like Growth Factor I; D003094:Collagen