The significance of substance P in physiological and malignant haematopoiesis.
The role of substance P (SP) in physiological haematopoiesis is well established. However, it also seems to be important in the neoplastic transformation of bone marrow, leading to the development of acute leukaemia in children, and also metastases to bone marrow of solid tumours (particularly neuroblastoma and breast cancer) in early stages of these diseases. This review summarises the available data on SP involvement in both processes. In the future, SP antagonists may be used as anti-neoplastic drugs, for example by direct or indirect blocking of tumour cell proliferation through inhibition of growth factor production and interleukin-1b synthesis.
Nowicki
Michal
M
Department of Histology and Embryology, Poznan University of Medical Sciences, Poland. mnowicki@amp.edu.pl
Ostalska-Nowicka
Danuta
D
Kondraciuk
Beata
B
Miskowiak
Bogdan
B
D000970:Antineoplastic Agents / Q000494:pharmacology; D001853:Bone Marrow / Q000473:pathology; D002471:Cell Transformation, Neoplastic / Q000378:metabolism*; D006410:Hematopoiesis / Q000502:physiology*; D006801:Humans; D007938:Leukemia / Q000378:metabolism; D009362:Neoplasm Metastasis; D009363:Neoplasm Proteins / Q000037:antagonists & inhibitors / Q000502:physiology*; D009369:Neoplasms / Q000378:metabolism; D013373:Substance P / Q000037:antagonists & inhibitors / Q000502:physiology*; D015320:Tachykinins / Q000502:physiology
D000970:Antineoplastic Agents; D009363:Neoplasm Proteins; D015320:Tachykinins; D013373:Substance P