Developmental, behavioral, and physiological phenotype of cloned mice.
Cloning from adult somatic cells has been successful in at least ten species. Although generating viable cloned mammals from adult cells is technically feasible, prenatal and perinatal mortality is high and live cloned offspring have had health problems. This chapter summarizes the health consequences of cloning in mice and discusses possible mechanisms through which these conditions may arise. These studies have further significance as other assisted reproductive techniques (ART) also involve some of the same procedures used in cloning, and there are some reports that offspring generated by ART display aberrant phenotypes as well. At the moment, the long-term consequences of mammalian cloning remain poorly characterized. Data available thus far suggest that we should use this technology with great caution until numerous questions are addressed and answered.
Tamashiro
Kellie L K
KL
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Ross 618, Baltimore, Maryland 21205, USA. ktamashiro@jhmi.edu
Sakai
Randall R
RR
Yamazaki
Yukiko
Y
Wakayama
Teruhiko
T
Yanagimachi
Ryuzo
R
D000818:Animals; D019976:Cloning, Organism / Q000379:methods* / Q000592:standards / Q000639:trends*; D000013:Congenital Abnormalities / Q000235:genetics / Q000503:physiopathology / Q000517:prevention & control; D004622:Embryo, Mammalian / Q000002:abnormalities / Q000503:physiopathology; D005260:Female; D008136:Longevity / Q000235:genetics; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D053652:Nuclear Transfer Techniques / Q000592:standards / Q000639:trends*; D009765:Obesity / Q000235:genetics / Q000503:physiopathology / Q000517:prevention & control; D010641:Phenotype; D035845:Research Embryo Creation / Q000379:methods* / Q000592:standards; D046509:Tissue Culture Techniques / Q000379:methods / Q000592:standards