Monocyte chemoattractant protein-1--a major contributor to the inflammatory process associated with diabetes.
There is evidence that strongly suggests that inflammation plays an important role in diabetes and cardiovascular diseases. The high glucose-induced inflammatory process is characterised by the cooperation of a complex network of inflammatory molecules such as cytokines, adhesion molecules, growth factors, and chemokines. Among the chemokine family, monocyte chemoattractant protein (MCP-1) is a potent chemotactic factor, which is upregulated at sites of inflammation being in control of leukocytes trafficking. Here, we review the current knowledge on MCP-1 and its regulation by high glucose level in vascular cells involved in diabetes-induced accelerated atherosclerosis. The signalling pathways involved in MCP-1 modulation by high glucose, the proximal signalling events that stimulate downstream effects and the role of this chemokine in the pathophysiology of diabetes and its complications, are discussed.
Dragomir
Elena
E
Institute of Cellular Biology and Pathology Nicolae Simionescu, Bucharest, Romania. elena.dragomir@icbp.ro
Simionescu
Maya
M
D050197:Atherosclerosis / Q000378:metabolism; D018932:Chemokine CCL2 / Q000378:metabolism*; D048909:Diabetes Complications / Q000378:metabolism; D003920:Diabetes Mellitus / Q000378:metabolism*; D004730:Endothelium, Vascular / Q000378:metabolism; D005786:Gene Expression Regulation; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D006943:Hyperglycemia / Q000378:metabolism; D007249:Inflammation / Q000378:metabolism*; D009000:Monocytes / Q000378:metabolism*; D032389:Myocytes, Smooth Muscle / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism; D015398:Signal Transduction; D015854:Up-Regulation
D018932:Chemokine CCL2; D017382:Reactive Oxygen Species; D005947:Glucose