Immunological-adjuvant saponins from the roots of Panax notoginseng.
The total saponin extract from the dried roots of Panax notoginseng (Burk.) F. H. Chen possesses immunological-adjuvant activities. Guided by in vivo immunological tests, further study on this fraction afforded three active dammarane-type saponins. Their structures were determined on the basis of chemical evidence and extensive spectroscopic methods, including 1D- and 2D-NMR. The novel compound (20S)-protopanaxatriol 20-O-beta-D-glucopyranosyl-(1-->6)-beta-D-glucopyranoside (1), and the two known compounds ginsenoside Rh4 (2) and notoginsenoside K (3) exhibited immunological-adjuvant activities on the humoral immune responses of ICR mice against ovalbumin (OVA).
Sun
Hongxiang
H
College of Animal Science, Zhejiang University, Hangzhou 310029, PR China. sunhx@zju.edu.cn
Ye
Yiping
Y
Pan
Yuanjian
Y
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D036145:Ginsenosides / Q000737:chemistry / Q000494:pharmacology; D007136:Immunoglobulins / Q000097:blood; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D015394:Molecular Structure; D010047:Ovalbumin; D053723:Panax notoginseng / Q000737:chemistry*; D018517:Plant Roots / Q000737:chemistry*; D012503:Saponins / Q000737:chemistry* / Q000494:pharmacology*
D036145:Ginsenosides; D007136:Immunoglobulins; D012503:Saponins; C101280:ginsenoside Rh4; C516809:notoginsenoside K; C516808:protopanaxatriol 20-O-glucopyranosyl-(1-->6)-glucopyranoside; D010047:Ovalbumin