title: Novel urease inhibitors from Daphne oleoids.
abstract: Phytochemical investigations on the chloroform and ethyl acetate soluble fractions of the roots of the Daphne oleoids led to the isolation of the coumarin glycosides 1-6. Compound 5 with IC50 values 22.05 and 26.30 microM repectively, was found to be the most active of these compounds when screened against Bacillus pasteurii and jack bean urease enzymes in a concentration-dependent fashion.
authors.affiliation: HEJ Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi 75270, Pakistan.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Ayaz
authors.forename: Muhammad Arif
authors.initials: MA
authors.lastname: Lodhi
authors.forename: Muhammad
authors.initials: M
authors.lastname: Riaz
authors.forename: Azhar
authors.initials: A
authors.lastname: Ul-haq
authors.forename: Abdul
authors.initials: A
authors.lastname: Malik
authors.forename: M Iqbal
authors.initials: MI
authors.lastname: Choudhary
mesh_terms: D032364:Daphne / Q000737:chemistry*; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014510:Urease / Q000037:antagonists & inhibitors* / Q000378:metabolism
chemical_list: D004791:Enzyme Inhibitors; D010936:Plant Extracts; D014510:Urease