Adult-onset asthma and periocular xanthogranulomas in a patient with lymphoplasmacytic sclerosing pancreatitis.
The clinical syndrome of adult-onset asthma and periocular xanthogranulomas represents a rare systemic autoimmune disorder that has not been previously associated with autoimmune pancreatitis. Herein, we describe the case report of a 61-year-old man with the unique clinical association of adult-onset asthma, atopy, and periocular xanthogranulomas, who had previously been diagnosed with lymphoplasmacytic sclerosing pancreatitis. We have previously reported the case of a patient with lymphoplasmacytic sclerosing pancreatitis that developed postoperative inflammatory pseudotumor of the orbit. These unique, extrapancreatic, ocular manifestations of this disease add to the published observations that it is a systemic disorder with the potential for multiorgan involvement that may have a spectrum of clinical manifestations that includes adult-onset asthma and periocular xanthogranulomas.
Roggin
Kevin K
KK
Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.
Rudloff
Udo
U
Klimstra
David S
DS
Russell
Linda A
LA
Blumgart
Leslie H
LH
D017668:Age of Onset; D001249:Asthma / Q000276:immunology* / Q000473:pathology; D001327:Autoimmune Diseases / Q000276:immunology / Q000473:pathology; D006104:Granuloma, Plasma Cell / Q000276:immunology* / Q000473:pathology; D006644:Histiocytes / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009915:Orbit / Q000473:pathology; D009916:Orbital Diseases / Q000276:immunology* / Q000473:pathology; D010195:Pancreatitis / Q000276:immunology* / Q000473:pathology; D010950:Plasma Cells / Q000473:pathology; D012598:Sclerosis; D014973:Xanthomatosis / Q000276:immunology* / Q000473:pathology