title: CNS involvement in hereditary neuropathy with pressure palsies (HNPP).
abstract: We assessed seven patients with hereditary neuropathy with liability to pressure palsies (HNPP) with 16 electrophysiological tests and cranial MRI for CNS abnormalities. Mean latencies differed between patients with HNPP and controls for the blink reflex, the jaw-opening reflex, and acoustic evoked potentials. MRI abnormalities were observed in four patients. Our study suggests subclinical but functionally relevant CNS myelin damage in HNPP.
authors.affiliation: Department of Neurology, Philipps-University, Marburg, Germany.
authors.forename: B
authors.initials: B
authors.lastname: Tackenberg
authors.forename: J C
authors.initials: JC
authors.lastname: Möller
authors.forename: H
authors.initials: H
authors.lastname: Rindock
authors.forename: S
authors.initials: S
authors.lastname: Bien
authors.forename: N
authors.initials: N
authors.lastname: Sommer
authors.forename: W H
authors.initials: WH
authors.lastname: Oertel
authors.forename: F
authors.initials: F
authors.lastname: Rosenow
authors.forename: K
authors.initials: K
authors.lastname: Schepelmann
authors.forename: H M
authors.initials: HM
authors.lastname: Hamer
authors.forename: O
authors.initials: O
authors.lastname: Bandmann
mesh_terms: D000328:Adult; D000368:Aged; D001921:Brain / Q000473:pathology* / Q000503:physiopathology*; D004569:Electroencephalography; D005071:Evoked Potentials; D005260:Female; D015417:Hereditary Sensory and Motor Neuropathy / Q000473:pathology* / Q000503:physiopathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009413:Nerve Fibers, Myelinated / Q000473:pathology*; D010243:Paralysis / Q000473:pathology* / Q000503:physiopathology*