title: Ubiquitin hubs in oncogenic networks.
abstract: Ubiquitin is an important regulator of diverse biological functions including cell cycle progression, apoptosis, cell proliferation, and DNA damage responses. Crucial proteins involved in the control of such diverse functions are modified by ubiquitin and are frequently altered during oncogenesis. Here, we define such proteins as key-nodes regulated by ubiquitin, discuss examples of their oncogenic aberrations, and indicate how pharmacologic manipulation of such molecular hubs might improve anticancer therapy.
authors.affiliation: Institute of Biochemistry II, Goethe University Hospital, Frankfort on the Main, Germany.
authors.forename: Nicola
authors.initials: N
authors.lastname: Crosetto
authors.forename: Marzena
authors.initials: M
authors.lastname: Bienko
authors.forename: Ivan
authors.initials: I
authors.lastname: Dikic
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D002453:Cell Cycle / Q000502:physiology*; D049109:Cell Proliferation; D004249:DNA Damage / Q000502:physiology*; D006801:Humans; D016328:NF-kappa B / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology; D016212:Transforming Growth Factor beta / Q000502:physiology; D025801:Ubiquitin / Q000502:physiology*; D051153:Wnt Proteins / Q000502:physiology
chemical_list: D016328:NF-kappa B; D016212:Transforming Growth Factor beta; D025801:Ubiquitin; D051153:Wnt Proteins