Human kallikrein 3 (prostate specific antigen) and human kallikrein 5 expression in salivary gland tumors.
The human kallikrein 5 protein (hK5) is expressed in many normal tissues, most notably in skin, breast, salivary gland and esophagus. It has also been shown to be a potential biomarker for breast, ovarian and testicular cancer. Human kallikrein 3 (hK3; prostate-specific antigen) is the most useful marker for adenocarcinoma of the prostate gland. The aim of this study was to determine whether hK3 and hK5 are expressed in salivary gland tissues and salivary gland tumors (both benign and malignant), in order to compare normal with tumor tissues. Pleomorphic adenomas, adenoid cystic carcinomas, polymorphous low-grade adenocarcinomas, acinic cell carcinomas, mucoepidermoid carcinomas and adenocarcinomas not otherwise specified of both minor and major salivary glands were examined. The results of this study indicate that most salivary gland tumors do not show high levels of expression of hK5. Staining was most prominent in keratinizing epithelia in pleomorphic adenomas. hK3 is not expressed in salivary gland tumors.
Darling
M R
MR
Division of Oral Pathology, Department of Pathology, University of Western Ontario, London, Ontario N6A 5C1, Canada. mark.darling@schulich.uwo.ca
Tsai
S
S
Jackson-Boeters
L
L
Daley
T D
TD
Diamandis
E P
EP
D014408:Biomarkers, Tumor / Q000032:analysis*; D006801:Humans; D007150:Immunohistochemistry; D007610:Kallikreins / Q000032:analysis*; D011379:Prognosis; D017430:Prostate-Specific Antigen / Q000032:analysis*; D012468:Salivary Gland Neoplasms / Q000737:chemistry*
D014408:Biomarkers, Tumor; C400147:KLK5 protein, human; D007610:Kallikreins; D017430:Prostate-Specific Antigen