Cognitive function and the emotional state of stroke patients on antihypertensive therapy.
Combined antihypertensive therapy based on 2.5-5 mg of cilazapril (an angiotensin-converting enzyme inhibitor) to normalize arterial pressure (ABP) was studied in 22 patients (12 male, 10 female) aged 49-74 years (mean 63 +/- 7 years) with stroke (18 patients) or transient ischemic attacks (three patients). Magnetic resonance tomography (MRT) including perfusion studies, along with neuropsychological studies and assessment of emotional status (Beck depression inventory, Spielberger anxiety scale), were performed before and after treatment. After six months of treatment, patients showed normalization of ABP (systolic pressure decreased from 154.7 +/- 12 to 128 +/- 23 mmHg, diastolic from 90.3 +/- 9.6 to 79.4 +/- 23 mmHg). There were no side effects and no patient experienced stroke. MRT revealed no signs of new foci and there were no significant changes in brain blood flow. By the end of treatment, improvements in cognitive functions were noted on the Mini Mental State Examination, the 10-word memory test, the Boston naming test, or the Wisconsin card-sorting test, though there were no changes in the patients' emotional status.
Starchina
Yu A
YA
I. M. Sechenov Moscow Medical Academy, Moscow, Russia.
Parfenov
V A
VA
Chazova
I E
IE
Sinitsyn
V E
VE
Pustovitova
T S
TS
Kolos
I P
IP
Ustyuzhanin
D V
DV
D000368:Aged; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D017315:Cilazapril / Q000627:therapeutic use*; D003071:Cognition / Q000187:drug effects*; D004644:Emotions / Q000187:drug effects*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D010555:Personality Inventory; D020521:Stroke / Q000188:drug therapy / Q000503:physiopathology / Q000523:psychology; D013997:Time Factors
D000959:Antihypertensive Agents; D017315:Cilazapril