title: Effect of Thymol on the spontaneous contractile activity of the smooth muscles.
abstract: Effects of Thymol on the spontaneous contractile activity (SCA) have been found in in vitro experiments with circular smooth-muscle strips (SMAs) from guinea pig stomach and vena portae. Thymol was found to possess an agonistic effect on the alpha(1)-, alpha(2)- and beta-adrenergic receptors. Its spasmolytic effect is registered at doses higher than 10(-6)M. Thymol in a dose of 10(-4)M inhibits 100% the SCA of the SMAs and reduces the excitatory effect of 10(-5)M ACH to 35%. It is assumed that Thymol has an analgesic effect through its action on the alpha(2)-adrenergic receptors of the nerve cells. By influencing the beta-adrenergic receptors in the adipose cells, it is possible to induce increased synthesis of fatty acids and glycerol, which is a prerequisite for increased heat release.
authors.affiliation: Department of True Naturopathy, Blankenstein Hospital, Im Vogelsang 5-11, 45527 Hattingen, Germany. andre.beer@klinik-Blankenstein.de
authors.forename: A-M
authors.initials: AM
authors.lastname: Beer
authors.forename: J
authors.initials: J
authors.lastname: Lukanov
authors.forename: P
authors.initials: P
authors.lastname: Sagorchev
mesh_terms: D000322:Adrenergic Agonists / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D004305:Dose-Response Relationship, Drug; D006168:Guinea Pigs; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects*; D008517:Phytotherapy; D011941:Receptors, Adrenergic / Q000187:drug effects; D013943:Thymol / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D046930:Thymus Plant
chemical_list: D000322:Adrenergic Agonists; D011941:Receptors, Adrenergic; D013943:Thymol