Endurance training: an effective and safe treatment for patients with LGMD2I.
We studied the effect of aerobic training on conditioning in patients with limb-girdle muscular dystrophy type 2I (LGMD2I). Nine patients with LGMD2I cycled fifty 30-minute sessions at 65% of their maximal oxygen uptake over 12 weeks. Training significantly improved work capacity, paralleled by self-reported improvements. Creatine kinase levels did not increase significantly, and muscle morphology was unaffected. Moderate-intensity endurance training is a safe method to increase exercise performance and daily function in patients with LGMD2I.
Sveen
M-L
ML
Department of Neurology 2082, Rigshospitalet, Blegdamsvej 9, DK-2100 Copenhagen, Denmark. RH18329@rh.hosp.dk
Jeppesen
T D
TD
Hauerslev
S
S
Krag
T O
TO
Vissing
J
J
D000328:Adult; D015444:Exercise / Q000502:physiology*; D005081:Exercise Therapy / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000473:pathology / Q000502:physiology; D049288:Muscular Dystrophies, Limb-Girdle / Q000473:pathology / Q000628:therapy*; D010807:Physical Endurance / Q000502:physiology*