title: Parathyroid-hormone-related-protein-associated hypercalcemia in a patient with CLL-type low-grade leukemic B-cell lymphoma.
abstract: Humoral hypercalcemia of malignancy is a common metabolic disturbance associated with solid tumors, but it also occurs in lymphoma patients. Among these, low grade B-cell lymphoma accounts for only few cases, in which secretion of parathyroid hormone-related protein (PTHrP) remains even exceptional. We report the very rare case of a patient with a CLL type low grade leukemic B-cell lymphoma showing PTHrP-related hypercalcemia without evidence of bone lesions. Using immunohistochemistry, we demonstrate the cytoplasmic expression of PTHrP by the lymphoma cells in the bone marrow obtained at the onset of hypercalcemia. We postulate a pathogenetic role of leukemic cell production and secretion of PTHrP in hypercalcemia in low grade leukemic B-cell lymphoma.
authors.affiliation: Medizinische Klinik und Poliklinik II, Julius-Maximilians-Universität Würzburg, Klinikstrasse 6-8, 97070 Würzburg, Germany. schoettker_b@klinik.uni-wuerzburg.de
authors.forename: Björn
authors.initials: B
authors.lastname: Schöttker
authors.forename: Werner
authors.initials: W
authors.lastname: Heinz
authors.forename: Florian
authors.initials: F
authors.lastname: Weissinger
authors.forename: Korkut
authors.initials: K
authors.lastname: Sözener
authors.forename: Matthias
authors.initials: M
authors.lastname: Eck
authors.forename: Jochen
authors.initials: J
authors.lastname: Seufert
mesh_terms: D000368:Aged; D001402:B-Lymphocytes / Q000378:metabolism / Q000473:pathology; D001853:Bone Marrow / Q000473:pathology; D017809:Fatal Outcome; D006801:Humans; D006934:Hypercalcemia / Q000209:etiology*; D006962:Hyperparathyroidism, Secondary / Q000209:etiology*; D016393:Lymphoma, B-Cell / Q000097:blood / Q000150:complications*; D008228:Lymphoma, Non-Hodgkin / Q000097:blood / Q000150:complications*; D008297:Male; D009363:Neoplasm Proteins / Q000378:metabolism*; D014411:Neoplastic Stem Cells / Q000378:metabolism; D009384:Paraneoplastic Endocrine Syndromes / Q000097:blood / Q000209:etiology*; D044162:Parathyroid Hormone-Related Protein / Q000378:metabolism*
chemical_list: D009363:Neoplasm Proteins; C470121:PTHLH protein, human; D044162:Parathyroid Hormone-Related Protein