title: Cyclic AMP-dependent memory mutants are defective in the food choice behavior of Drosophila.
abstract: Acute choice behavior in ingesting two different concentrations of sucrose in Drosophila is presumed to include learning and memory. Effects on this behavior were examined for four mutations that block associative learning (dunce, rutabaga, amnesiac, and radish). Three of these mutations cause cyclic AMP signaling defects and significantly reduced taste discrimination. The exception was radish, which affects neither. Electrophysiological recordings confirmed that the sensitivity of taste receptors is almost indistinguishable in all flies, whether wild type or mutant. These results suggest that food choice behavior in Drosophila involves central nervous learning and memory operating via cyclic AMP signaling pathways.
authors.affiliation: Department of Developmental Biology and Neuroscience, Graduate School of Life Sciences, Tohoku University, Sendai 980-8578, Japan.
authors.forename: Katsunori
authors.initials: K
authors.lastname: Motosaka
authors.forename: Masayuki
authors.initials: M
authors.lastname: Koganezawa
authors.forename: Satoko
authors.initials: S
authors.lastname: Narikawa
authors.forename: Akira
authors.initials: A
authors.lastname: Furuyama
authors.forename: Kenji
authors.initials: K
authors.lastname: Shinozaki
authors.forename: Kunio
authors.initials: K
authors.lastname: Isono
authors.forename: Ichiro
authors.initials: I
authors.lastname: Shimada
mesh_terms: D000262:Adenylyl Cyclases / Q000235:genetics / Q000378:metabolism; D000704:Analysis of Variance; D000818:Animals; D002755:Choice Behavior / Q000502:physiology*; D000242:Cyclic AMP / Q000235:genetics / Q000378:metabolism*; D004193:Discrimination Learning / Q000502:physiology; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism*; D004331:Drosophila melanogaster / Q000235:genetics / Q000378:metabolism*; D005247:Feeding Behavior / Q000502:physiology; D005518:Food Preferences / Q000502:physiology*; D008568:Memory / Q000502:physiology; D009154:Mutation; D009479:Neuropeptides / Q000235:genetics / Q000378:metabolism; D010750:Phosphoproteins / Q000235:genetics / Q000378:metabolism; D015290:Second Messenger Systems / Q000235:genetics / Q000502:physiology; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology; D018709:Statistics, Nonparametric
chemical_list: D029721:Drosophila Proteins; D009479:Neuropeptides; D010750:Phosphoproteins; C093565:amn protein, Drosophila; C515827:rad protein, Drosophila; D000242:Cyclic AMP; D000262:Adenylyl Cyclases; C479926:Rut protein, Drosophila