title: Association of dopamine transporter genotype with disruptive behavior disorders in an eight-year longitudinal study of children and adolescents.
abstract: Associations between dopamine transporter (DAT1) variable number tandem repeats (VNTR), genotypes, and disruptive behavior were examined in an 8-year longitudinal study of children (n = 183). Half of the children met criteria for attention-deficit/hyperactivity disorder (ADHD) at 4-6 years and half were non-referred comparison children. Consistent with several studies, the non-additive association for the 10-repeat allele was significant for hyperactivity-impulsivity (HI) symptoms. However, consistent with other studies, exploratory analyses of the non-additive association of the 9-repeat allele of DAT1 with HI and oppositional defiant disorder (ODD) symptoms also were significant. The inconsistent association between DAT1 and child behavior problems in this and other samples may reflect joint influence of the 10-repeat and 9-repeat alleles.
authors.affiliation: Department of Psychology, University of California, Los Angeles, California 90095-1563, USA. stevelee@psych.ucla.edu
authors.forename: Steve S
authors.initials: SS
authors.lastname: Lee
authors.forename: Benjamin B
authors.initials: BB
authors.lastname: Lahey
authors.forename: Irwin
authors.initials: I
authors.lastname: Waldman
authors.forename: Carol A
authors.initials: CA
authors.lastname: Van Hulle
authors.forename: Paul
authors.initials: P
authors.lastname: Rathouz
authors.forename: William E
authors.initials: WE
authors.lastname: Pelham
authors.forename: Jan
authors.initials: J
authors.lastname: Loney
authors.forename: Edwin H
authors.initials: EH
authors.lastname: Cook
mesh_terms: D000293:Adolescent; D001288:Attention; D019958:Attention Deficit and Disruptive Behavior Disorders / Q000208:ethnology / Q000235:genetics*; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D050483:Dopamine Plasma Membrane Transport Proteins / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D008040:Genetic Linkage; D005838:Genotype; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D018598:Minisatellite Repeats / Q000235:genetics; D011110:Polymorphism, Genetic
chemical_list: D050483:Dopamine Plasma Membrane Transport Proteins; C493214:SLC6A3 protein, human