Bacteroides fragilis synthesizes a DNA invertase affecting both a local and a distant region.
The activity of a fourth conserved tyrosine site-specific recombinase (Tsr) of Bacteroides fragilis was characterized. Its gene, tsr19, is adjacent to mpi, encoding the global DNA invertase regulating capsular polysaccharide biosynthesis. Unlike the other described Tsrs of B. fragilis, Tsr19 brings about inversion of two DNA regions, one local and one located distantly.
Roche-Hakansson
Hazeline
H
Channing Laboratory, 181 Longwood Avenue, Boston, MA 02115, USA.
Chatzidaki-Livanis
Maria
M
Coyne
Michael J
MJ
Comstock
Laurie E
LE
D000595:Amino Acid Sequence; D016667:Bacterial Capsules / Q000096:biosynthesis*; D001426:Bacterial Proteins / Q000235:genetics; D001441:Bacteroides fragilis / Q000201:enzymology* / Q000235:genetics; D001483:Base Sequence; D018833:Chaperonins / Q000235:genetics; D004254:DNA Nucleotidyltransferases / Q000235:genetics / Q000502:physiology*; D008969:Molecular Sequence Data; D011401:Promoter Regions, Genetic
D001426:Bacterial Proteins; C097970:GroESL protein, Bacteria; D004254:DNA Nucleotidyltransferases; C077570:Site-specific recombinase; D018833:Chaperonins