Abietane diterpenoids from the roots of some Mexican Salvia species (Labiatae): chemical diversity, phytogeographical significance, and cytotoxic activity.
From the roots of some Mexican Salvia species, classified in subgenus Jungia, several diterpenoids belonging to abietane (i.e., 3-7), salvifolane (9-->20,10-->6)-diabeoabietane) (i.e., 2), and totarane (i.e., 10) carbocyclic skeletons were isolated together with two 20-nor- and one 6,7-secoabietane derivatives, 1 and 9, and 8, respectively. While compounds 2-10 were previously known from different sources, compound 1 is a new 20-norabietane derivative, whose structure was deduced by spectroscopic means and confirmed by X-ray-diffraction analysis. The phytogeographical significance of the distribution of 20-norabietanic diterpenoids in the genus suggested an evolutionary link between the Chinese and New-World Salvias. Compounds 2 and 8 were tested for cell-growth inhibition activity against several human cancer cell lines and human normal lymphocytes, while 2 showed a moderate cytotoxic activity, 8 exhibited a moderate yet selective activity against leukemia cell line.
Esquivel
Baldomero
B
Instituto de Química de la Universidad Nacional Autónoma de México, Circuito Exterior de Ciudad Universitaria, Coyoacán, 04510, México DF. baldo@servidor.unam.mx
Sánchez
Ana Adela
AA
Vergara
Fredd
F
Matus
Wilber
W
Hernandez-Ortega
Simón
S
Ramírez-Apan
M Teresa
MT
D045784:Abietanes / Q000737:chemistry* / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000494:pharmacology*; D005075:Biological Evolution; D045744:Cell Line, Tumor; D006801:Humans; D008958:Models, Molecular; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry; D027544:Salvia / Q000737:chemistry* / Q000378:metabolism*
D045784:Abietanes; D000972:Antineoplastic Agents, Phytogenic