title: Incidence of end-stage renal disease among live kidney donors.
abstract: BACKGROUND
  The increasing use of living kidney donors requires knowledge about long-term effects, especially number and causes of donors with end-stage renal disease (ESRD).
  
  
  METHODS
  A retrospective data analysis of 1,112 consecutive living kidney donors who underwent nephrectomy from 1965 until 2005 at Sahlgrenska University Hospital. Case reports were sought with help from nephrologists in the region and data from Swedish Registry of Active Uremic Treatment (SRAU).
  
  
  RESULTS
  The number of cases with end stage kidney failure among living kidney donors was 6/1112, that is 0.5%. The donors had reached ESRD during the years 2001-2006, that means 36-41 years after start of the living donor program. The donors were 45-89 years old, median 77 years, and five of six were males. Time since donation was 14-27 years, median 20 years, for the donors developing ESRD. The diagnoses were nephrosclerosis (4 cases), postrenal failure (1 case), and renal carcinoma (1 case). The expected incidence for development of ESRD according to incidence in the general population would have been two donors but we found six. However, considering the high age of the donors in this follow up, the age-matched incidence is calculated to be closer to six donors due to higher incidence in the aged.
  
  
  CONCLUSIONS
  In all 0.5% of the donors developed ESRD. Due to high age of the uremic donors, there seems to be no increased incidence.
authors.affiliation: Department of Transplantation and Liver Surgery, Sahlgrenska University Hospital, Göteborg, Sweden. ingela.fehrman-ekholm@vgregion.se
authors.forename: Ingela
authors.initials: I
authors.lastname: Fehrman-Ekholm
authors.forename: Gunnela
authors.initials: G
authors.lastname: Nordén
authors.forename: Annette
authors.initials: A
authors.lastname: Lennerling
authors.forename: Magnus
authors.initials: M
authors.lastname: Rizell
authors.forename: Lars
authors.initials: L
authors.lastname: Mjörnstedt
authors.forename: Lars
authors.initials: L
authors.lastname: Wramner
authors.forename: Michael
authors.initials: M
authors.lastname: Olausson
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D015994:Incidence; D007676:Kidney Failure, Chronic / Q000453:epidemiology*; D016030:Kidney Transplantation; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013548:Sweden / Q000453:epidemiology