title: Ascending the learning curve--MSI testing experience of a six-laboratory consortium.
abstract: According to recently published guidelines, microsatellite instability (MSI) testing of colorectal cancers may be clinically indicated on a significant proportion of all colorectal tumors. To date, nothing has been published regarding the reproducibility of MSI testing between laboratories. We present MSI quality control activities experience of a six center multinational consortium, as laboratories developed competency with MSI testing and interpretation. The aim of this paper is to share lessons learned and to describe the final concordance rates in scoring MSI markers within this consortium.
authors.affiliation: Department of Medical Genetics, Mayo Clinic, Rochester, MN 55905, USA. nlindor@mayo.edu
authors.forename: Noralane M
authors.initials: NM
authors.lastname: Lindor
authors.forename: Regenia
authors.initials: R
authors.lastname: Smalley
authors.forename: Melissa
authors.initials: M
authors.lastname: Barker
authors.forename: Jeannette
authors.initials: J
authors.lastname: Bigler
authors.forename: Lisa M
authors.initials: LM
authors.lastname: Krumroy
authors.forename: Annette
authors.initials: A
authors.lastname: Lum-Jones
authors.forename: Sarah J
authors.initials: SJ
authors.lastname: Plummer
authors.forename: Teresa
authors.initials: T
authors.lastname: Selander
authors.forename: Sushma
authors.initials: S
authors.lastname: Thomas
authors.forename: Michelle
authors.initials: M
authors.lastname: Youash
authors.forename: Daniela
authors.initials: D
authors.lastname: Seminara
authors.forename: Graham
authors.initials: G
authors.lastname: Casey
authors.forename: Bharati
authors.initials: B
authors.lastname: Bapat
authors.forename: Stephen N
authors.initials: SN
authors.lastname: Thibodeau
mesh_terms: D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000235:genetics*; D006801:Humans; D053842:Microsatellite Instability; D018895:Microsatellite Repeats / Q000235:genetics*; D011786:Quality Control; D012042:Registries