title: Regulation of membrane trafficking and endocytosis by protein kinase C: emerging role of the pericentrion, a novel protein kinase C-dependent subset of recycling endosomes.
abstract: The protein kinase C (PKC) family of isoenzymes has been shown to regulate a variety of cellular processes, including receptor desensitization and internalization, and this has sparked interest in further delineation of the roles of specific isoforms of PKC in membrane trafficking and endocytosis. Recent studies have identified a novel translocation of PKC to a juxtanuclear compartment, the pericentrion, which is distinct from the Golgi complex but epicentered on the centrosome. Sustained activation of PKC (longer than 30 min) also results in sequestration of plasma membrane lipids and proteins to the same compartment, demonstrating a global effect on endocytic trafficking. This review summarizes these studies, particularly focusing on the characterization of the pericentrion as a distinct PKC-dependent subset of recycling endosomes. We also discuss emerging insights into a role for PKC as a central hub in regulating vesicular transport pathways throughout the cell, with implications for a wide range of pathobiologic processes, e.g. diabetes and abnormal neurotransmission or receptor desensitization.
authors.affiliation: Department of Biochemistry and Molecular Biology, Medical University of South Carolina, 173 Ashley Avenue, PO Box 250209, Charleston, South Carolina 29425, USA.
authors.forename: F
authors.initials: F
authors.lastname: Alvi
authors.forename: J
authors.initials: J
authors.lastname: Idkowiak-Baldys
authors.forename: A
authors.initials: A
authors.lastname: Baldys
authors.forename: J R
authors.initials: JR
authors.lastname: Raymond
authors.forename: Y A
authors.initials: YA
authors.lastname: Hannun
mesh_terms: D000818:Animals; D002462:Cell Membrane / Q000201:enzymology*; D004705:Endocytosis; D011992:Endosomes / Q000378:metabolism*; D006801:Humans; D011493:Protein Kinase C / Q000378:metabolism*; D021381:Protein Transport; D015398:Signal Transduction
chemical_list: D011493:Protein Kinase C