Efficacy and plasma concentrations of indinavir when boosted with ritonavir in human immunodeficiency virus-infected Thai children.
We evaluated 19 children using 220-300 mg/m of indinavir (IDV) boosted with 100 mg ritonavir (RTV) (n = 12) or full-dose RTV (n = 7). Geometric mean (GM) (90% confidence interval, CI) of IDV Ctrough in children who took IDV with 100 mg RTV (n = 12) was 0.17 (0.06-0.50) mg/L. For children who took IDV with full-dosage RTV, GM (90% CI) was 0.40 (0.10-1.61) mg/L. C2hours were less than 10 mg/L in all subjects. Eighteen children had good virologic response. This report demonstrates that smaller IDV dosages given with RTV provide efficacious plasma concentrations and can be safely used.
Plipat
Nottasorn
N
Division of Pediatric Infectious Diseases, Department of Pediatrics, Siriraj Hospital, Mahidol University, Bangkok, Thailand. nplipat@msn.com
Cressey
Tim R
TR
Vanprapar
Nirun
N
Chokephaibulkit
Kulkanya
K
D023241:Antiretroviral Therapy, Highly Active / Q000379:methods; D002648:Child; D004357:Drug Synergism; D005260:Female; D015658:HIV Infections / Q000097:blood / Q000188:drug therapy*; D006801:Humans; D019469:Indinavir / Q000008:administration & dosage* / Q000097:blood; D008297:Male; D019438:Ritonavir / Q000008:administration & dosage* / Q000097:blood; D013785:Thailand
D019469:Indinavir; D019438:Ritonavir