Markers of human papillomavirus infection and their correlation with cervical dysplasia in human immunodeficiency virus-positive women.
Human papillomavirus (HPV) genotypes and HPV DNA load were analysed in cervical smears from 76 human immunodeficiency virus (HIV)-positive and 54 HIV-negative women. The prevalence of genotypes was similar for all women, with the exception of HPV62, which was over-represented in HIV-positive samples. HIV-positive women showed a higher prevalence of multiple genotypes that correlated neither with CD4(+) T-cell counts nor with cervical dysplasia. No significant differences were observed in terms of total or single-type HPV DNA load. The HPV DNA load in both HIV-positive and HIV-negative women was significantly higher in squamous intra-epithelial lesions than in negative Pap smears.
Riva
E
E
Virology Section, University Campus Bio-Medico, Spallanzani Hospital, Rome, Italy.
Serraino
D
D
Pierangeli
A
A
Bambacioni
F
F
Zaniratti
S
S
Minosse
C
C
Selleri
M
M
Bucci
M
M
Scagnolari
C
C
Degener
A M
AM
Capobianchi
M R
MR
Antonelli
G
G
Dianzani
F
F
D000328:Adult; D004279:DNA, Viral / Q000235:genetics; D005260:Female; D005819:Genetic Markers / Q000235:genetics; D006678:HIV; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D008875:Middle Aged; D018307:Neoplasms, Squamous Cell / Q000150:complications* / Q000821:virology*; D027383:Papillomaviridae / Q000145:classification / Q000235:genetics*; D030361:Papillomavirus Infections / Q000150:complications* / Q000821:virology*; D016133:Polymerase Chain Reaction; D013045:Species Specificity; D002578:Uterine Cervical Dysplasia / Q000150:complications* / Q000821:virology*
D004279:DNA, Viral; D005819:Genetic Markers