title: Metastatic mucinous carcinoma of the eyelid.
abstract: Metastatic eyelid tumours are rare and account for less than 2% of all eyelid neoplasms. We report a case of metastatic breast carcinoma to the eyelid in a 60-year-old Chinese lady presenting with a 2-year history of enlarging, painless nodular lower eyelid swelling. The 1 cm diameter lesion was provisionally diagnosed as a sebaceous cyst. However the excision biopsy revealed a mucinous carcinoma expressing oestrogen receptor protein. She had a past history of mastectomy one year previously and histology showed an infiltrating ductal carcinoma (oestrogen receptor status negative) without evidence of axillary lymph node metastasis. She had completed adjuvant radio- and chemotherapy. Further treatment of the current lesion involved a wide excision which did not show any residual malignancy. She had no other evidence of metastasis and was treated with letrozol. We highlight this case to create awareness among clinicians and opthalmologists on the possibility of metastatic disease as a cause of eyelid swelling, especially in patients with a history of cancer. It may also be the first sign of metastatic disease of an internal malignancy. A review of the literature is also presented.
authors.affiliation: Advanced Medical and Dental Institute, Universiti Sains Malaysia, Penang.
authors.forename: Gurjeet
authors.initials: G
authors.lastname: Kaur
authors.forename: Rosli
authors.initials: R
authors.lastname: Ismail
authors.forename: Hairulhasliza
authors.initials: H
authors.lastname: Harun
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000378:metabolism / Q000556:secondary* / Q000628:therapy; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000473:pathology*; D018270:Carcinoma, Ductal, Breast / Q000378:metabolism / Q000473:pathology / Q000556:secondary*; D003937:Diagnosis, Differential; D004814:Epidermal Cyst / Q000473:pathology; D005142:Eyelid Neoplasms / Q000378:metabolism / Q000556:secondary* / Q000628:therapy; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008296:Malaysia; D008875:Middle Aged; D011960:Receptors, Estrogen / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D011960:Receptors, Estrogen