title: Lack of Toll-like receptor 4 and 2 polymorphisms in Korean patients with bacteremia.
abstract: Toll-like receptors (TLRs) are pattern-recognition receptors that are important in innate immune responses to bacterial infection. The purpose of this study is to describe the prevalence of TLRs genetic variations in the bacteremic patients in Korea. A total of 154 patients with bacteremia and 179 healthy volunteers were included. The Asp299Gly and Thr399Ile allele of the TLR4 gene and Arg753Gln and Arg677Trp allele of the TLR2 gene were tested by PCR-RFLP. The DNA sequences were determined to confirm the PCR-RFLP results. Contrary to the expectation, no genetic polymorphisms were detected in both groups of this study, suggesting that it is very rare in Korean.
authors.affiliation: Department of Internal Medicine, Eulji University College of Medicine, Daejeon, Korea.
authors.forename: Hee Jung
authors.initials: HJ
authors.lastname: Yoon
authors.forename: Jun Yong
authors.initials: JY
authors.lastname: Choi
authors.forename: Chang Oh
authors.initials: CO
authors.lastname: Kim
authors.forename: Yoon Seon
authors.initials: YS
authors.lastname: Park
authors.forename: Myoung Soo
authors.initials: MS
authors.lastname: Kim
authors.forename: Young Keun
authors.initials: YK
authors.lastname: Kim
authors.forename: So Youn
authors.initials: SY
authors.lastname: Shin
authors.forename: June Myung
authors.initials: JM
authors.lastname: Kim
authors.forename: Young Goo
authors.initials: YG
authors.lastname: Song
mesh_terms: D016470:Bacteremia / Q000097:blood / Q000453:epidemiology* / Q000235:genetics*; D015415:Biomarkers / Q000097:blood; D004252:DNA Mutational Analysis; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000235:genetics; D005820:Genetic Testing / Q000379:methods; D006801:Humans; D007723:Korea / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D015995:Prevalence; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D051195:Toll-Like Receptor 2 / Q000097:blood / Q000235:genetics*; D051197:Toll-Like Receptor 4 / Q000097:blood / Q000235:genetics*
chemical_list: D015415:Biomarkers; C495342:TLR2 protein, human; C495345:TLR4 protein, human; D051195:Toll-Like Receptor 2; D051197:Toll-Like Receptor 4