title: Effect of sarcopenia on cardiovascular disease risk factors in obese postmenopausal women.
abstract: OBJECTIVE
  To compare sarcopenic-obese and obese postmenopausal women for risk factors predisposing to cardiovascular disease (CVD) and determine whether there may be a relationship between muscle mass and metabolic risk in obese postmenopausal women.
  
  
  METHODS
  In this cross-sectional study, 22 healthy obese postmenopausal women (mean age, 66 +/- 5 years; mean BMI, 27 +/- 3 kg/m(2)) were divided into two groups matched for age (+/-2 years) and fat mass (FM) (+/-2%). Sarcopenia was defined as a muscle mass index of <14.30 kg fat-free mass (FFM)/m(2) (which corresponds to 1 standard deviation below the values of a young reference population), and obesity was defined as an FM of >35% (which corresponds to the World Health Organization guidelines). FM, FFM (measured by DXA), daily energy expenditure (accelerometry), dietary intake (3-day dietary record), and blood biochemical analyses (lipid profile, insulin, glucose, and C-reactive protein) were obtained. Visceral fat mass (VFM) was calculated by the equation of Bertin, which estimates VFM from DXA measurements.
  
  
  RESULTS
  Obese women had more FFM (p = 0.006), abdominal FM (p = 0.047), and VFM (p = 0.041) and a worse lipid profile [p = 0.040 for triglycerides; p = 0.004 for high-density lipoprotein (HDL); p = 0.026 for total cholesterol/HDL] than sarcopenic-obese postmenopausal women. Obese women also ingested significantly more animal (p = 0.001) and less vegetal proteins (p = 0.013), although both groups had a similar total protein intake (p = 0.967).
  
  
  CONCLUSIONS
  Sarcopenia seems to be associated with lower risk factors predisposing to CVD in obese postmenopausal women. With the increase in the number of aging people, the health implications of being sarcopenic-obese merit more attention.
authors.affiliation: Research Centre on Aging, 1036 Belvédère Sud, Sherbrooke, Québec, Canada J1H 4C4.
authors.forename: Mylène
authors.initials: M
authors.lastname: Aubertin-Leheudre
authors.forename: Christine
authors.initials: C
authors.lastname: Lord
authors.forename: Eric D B
authors.initials: ED
authors.lastname: Goulet
authors.forename: Abdelouahed
authors.initials: A
authors.lastname: Khalil
authors.forename: Isabelle J
authors.initials: IJ
authors.lastname: Dionne
mesh_terms: D000368:Aged; D000375:Aging / Q000097:blood / Q000378:metabolism; D001823:Body Composition / Q000502:physiology*; D002318:Cardiovascular Diseases / Q000097:blood / Q000453:epidemiology* / Q000209:etiology; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D003430:Cross-Sectional Studies; D004032:Diet; D005260:Female; D006801:Humans; D008875:Middle Aged; D009133:Muscular Atrophy / Q000097:blood / Q000150:complications*; D009765:Obesity / Q000097:blood / Q000150:complications*; D017698:Postmenopause; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood
chemical_list: D008076:Cholesterol, HDL; D014280:Triglycerides; D002784:Cholesterol