Exploiting 4-1BB costimulation for enhancing antiviral vaccination.
4-1BB, a member of the tumor necrosis factor receptor (TNFR) superfamily, is emerging as an important costimulatory molecule, particularly in the regulation of CD8(+) T cell responses. Costimulation through 4-1BB, such as by utilizing agonistic anti-4-1BB monoclonal antibodies, has been well studied in various tumor models. However, 4-1BB is also an important regulator of antiviral CD8(+) T cell responses. This review summarizes these findings and describes how 4-1BB is beginning to be exploited in terms of boosting antiviral vaccine responses.
Harrison
Jodie M
JM
Department of Immunology and Genetics, John Curtin School of Medical Research, Australian National University, Canberra, Australia.
Bertram
Edward M
EM
Ramshaw
Ian A
IA
D053330:4-1BB Ligand / Q000008:administration & dosage / Q000819:agonists / Q000276:immunology*; D000911:Antibodies, Monoclonal / Q000276:immunology; D000914:Antibodies, Viral / Q000008:administration & dosage / Q000276:immunology; D000938:Antigen-Presenting Cells / Q000378:metabolism; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate; D008213:Lymphocyte Activation; D014611:Vaccination / Q000379:methods*; D014765:Viral Vaccines / Q000008:administration & dosage; D014777:Virus Diseases / Q000276:immunology*; D014780:Viruses / Q000276:immunology
D053330:4-1BB Ligand; D000911:Antibodies, Monoclonal; D000914:Antibodies, Viral; D014765:Viral Vaccines