[Correction of free radical processes in patients with ischemic heart disease using bicycle exercise with free choice of load].
The aim of the study was to examine changes in the system lipid peroxidation-antioxidant defense (LPO-AOD) in patients with ischemic heart disease (IHD) exercising on the bicycle in free load regime. A course of standard medication in IHD patients reduced the level of lipid peroxidation by 15.1% (p < 0.05), on the average, malonic dialdehyde (MDA)--by 21.4% (p < 0.05), but at the end of the treatment these parameters did not reach those of healthy subjects and remained higher than they had. The addition of bicycle exercise in the treatment reduced LPO to the level of healthy subjects. AOD also changed in trained IHD patients: catalase activity rose in the trained patients by 22.6% (p < 0.001), on the average, that of superoxide dismutase--by 19.0% (p < 0.05). Total antioxidant activity of erythrocytes in trained patients rose by 24.0% (p < 0.01), total antioxidant activity of plasma increased by 43.3%. Thus, free bicycle exercise raises antiradical potential of blood in IHD patients. The effect of the exercise was the highest on the enzymes of AOD system.
Chursina
T V
TV
Shcherbatykh
S I
SI
D000368:Aged; D002374:Catalase / Q000097:blood; D004912:Erythrocytes / Q000201:enzymology / Q000378:metabolism; D005080:Exercise Test; D005081:Exercise Therapy / Q000379:methods*; D005260:Female; D005609:Free Radicals / Q000378:metabolism*; D006801:Humans; D015227:Lipid Peroxidation / Q000502:physiology; D008054:Lipid Peroxides / Q000097:blood; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000378:metabolism / Q000628:therapy*; D013482:Superoxide Dismutase / Q000097:blood; D016896:Treatment Outcome
D005609:Free Radicals; D008054:Lipid Peroxides; D002374:Catalase; D013482:Superoxide Dismutase