The pathology of ageing: concepts and mechanisms.
The rising numbers and proportion of aged individuals in the population is a global demographic trend. The diseases associated with ageing are becoming more prevalent, and the associated healthcare costs are having a significant economic impact in all countries. With these changes have come great advances in our understanding of the mechanisms of ageing. The mechanisms of cellular ageing at a genetic, protein and organelle level are becoming clearer, as are some of the more complex associations between environment and ageing. System ageing is also becoming better understood, and the potential biological advantages of ageing are being explored. Many of the advances in these fields are opening up the prospect of targeted therapeutic intervention for ageing and age related disease.
Martin
J E
JE
Pathology Group, Institute of Cell and Molecular Sciences, St Bartholomew's and the London Hospital School of Medicine and Dentistry, London, UK.
Sheaff
M T
MT
D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000473:pathology* / Q000502:physiology; D016922:Cellular Senescence / Q000502:physiology; D019049:Developed Countries; D003906:Developing Countries; D017048:Health Care Costs; D006801:Humans; D008875:Middle Aged