Impact of visceral involvements and blood cell count abnormalities on survival in adult T-cell leukemia/lymphoma (ATLL).
Multiple visceral involvements and various blood cell count abnormalities are frequently manifested in adult T-cell leukemia/lymphoma (ATLL) at diagnosis. We evaluated the effects of four visceral involvement (bone marrow (BM), skin, liver, spleen) and six blood cell count abnormalities (anemia, neutrophilia, thrombocytopenia, monocytosis, eosinophilia, basophilia) on the overall survival of 168 ATLL patients. In the aggressive type, BM involvement, skin involvement and monocytosis were significantly poor prognostic factors. Furthermore, concomitant involvement of BM and additional visceral organs worsened the prognosis. These data support that multiple organ involvements represent a poor prognostic factor for ATLL and provide clinical significance for BM examinations.
Takasaki
Yumi
Y
Department of Molecular Medicine and Hematology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Science, Nagasaki, Japan.
Iwanaga
Masako
M
Tsukasaki
Kunihiro
K
Kusano
Miyuki
M
Sugahara
Kazuyuki
K
Yamada
Yasuaki
Y
Kamihira
Shimeru
S
Ikeda
Shuichi
S
Tomonaga
Masao
M
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000740:Anemia / Q000150:complications / Q000175:diagnosis / Q000401:mortality / Q000473:pathology*; D001853:Bone Marrow / Q000473:pathology*; D005260:Female; D006801:Humans; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000150:complications / Q000175:diagnosis / Q000401:mortality / Q000473:pathology*; D007960:Leukocyte Disorders / Q000150:complications / Q000175:diagnosis / Q000401:mortality / Q000473:pathology*; D008099:Liver / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D012867:Skin / Q000473:pathology; D013154:Spleen / Q000473:pathology