title: Familial central retinal vein occlusion.
abstract: OBJECTIVE
  To report four cases of central retinal vein occlusion (CRVO) in a French family.
  
  
  METHODS
  Ophthalmological examination and medical work-up of seven members of the family.
  
  
  RESULTS
  There were four cases of CRVO in two consecutive generations. Three of them had CRVO in both eyes. Arterial hypertension was present in two, associated to glaucoma in one. Medical work-up did not reveal additional risk factors.
  
  
  CONCLUSIONS
  We report a case of familial clustering of CRVO. Our cases combined to other cases reported in the literature provide arguments for the existence in some subjects of a genetic predisposition of CRVO. Additional case series are however needed to confirm this hypothesis.
authors.affiliation: Department of Ophthalmology of the Fondation Ophtalmologique Rothschild and of the Centre Hospitalier National des Quinze-Vingts, Université Pierre et Marie Curie, Paris, France.
authors.forename: J-F
authors.initials: JF
authors.lastname: Girmens
authors.forename: S
authors.initials: S
authors.lastname: Scheer
authors.forename: E
authors.initials: E
authors.lastname: Héron
authors.forename: J-A
authors.initials: JA
authors.lastname: Sahel
authors.forename: E
authors.initials: E
authors.lastname: Tournier-Lasserve
authors.forename: M
authors.initials: M
authors.lastname: Paques
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D012170:Retinal Vein Occlusion / Q000235:genetics*