Ethnic differences in plasma levels of interleukin-8 (IL-8) and granulocyte colony stimulating factor (G-CSF).
Ethnic neutropenia is common in people of African descent. As interleukin-8 (IL-8) and granulocyte colony stimulating factor (G-CSF) bind to receptors on neutrophils, ethnic differences in neutrophil counts are hypothesized to result in different plasma levels of these cytokines. A prospective study was conducted in 72 healthy young volunteers. Neutrophil counts were 60% higher in Caucasians (P<0.00001). Average IL-8 and G-CSF levels were about 50% and 70% higher in African volunteers compared with Caucasian volunteers (P=0.0008 and P=0.00005, respectively). Additionally, oxidative burst capacity in stimulated neutrophils was significantly lower in volunteers of African descent (P=0.03 between both groups). In sum, lower neutrophil counts are associated with higher levels of IL-8 and G-CSF in Africans.
Mayr
Florian B
FB
Department of Clinical Pharmacology, Medical University Vienna, Austria.
Spiel
Alexander O
AO
Leitner
Judith M
JM
Firbas
Christa
C
Kliegel
Tuende
T
Jilma
Bernd
B
D000293:Adolescent; D000328:Adult; D044383:Black People; D016179:Granulocyte Colony-Stimulating Factor / Q000097:blood* / Q000235:genetics; D006801:Humans; D016209:Interleukin-8 / Q000097:blood* / Q000235:genetics; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012333:RNA, Messenger / Q000032:analysis; D044465:White People
D016209:Interleukin-8; D012333:RNA, Messenger; D016179:Granulocyte Colony-Stimulating Factor