title: Heterotopic ossification in skeletal muscle metastasis from colonic adenocarcinoma--a case report.
abstract: Colonic adenocarcinoma metastasising to the skeletal muscle is rare. A-56-yr-old Malay man was diagnosed to have adenocarcinoma of the right colon [Dukes B] for which a right hemicolectomy was performed, followed by radiotherapy and chemotherapy. Five years later the patient presented with a mass in the rectus abdominis muscle. The serum carcinoembryonic antigen was 71 ng/Ml. The mass was resected. Gross and microscopical examination showed multiple deposits of mucin-secreting adenocarcinoma with prominent heterotopic ossification in the stroma. The exact pathogenesis and significance of heterotopic ossification is not clear, but bone morphogenetic proteins may play an important role.
authors.affiliation: Department of Pathology, School of Medical Sciences, Universiti Sains Malaysia. venkatesh@kb.usm.my
authors.forename: Venkatesh R
authors.initials: VR
authors.lastname: Naik
authors.forename: Hasnan
authors.initials: H
authors.lastname: Jaafar
authors.forename: Samarendra S
authors.initials: SS
authors.lastname: Mutum
mesh_terms: D000230:Adenocarcinoma / Q000556:secondary*; D003110:Colonic Neoplasms / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000473:pathology*; D009999:Ossification, Heterotopic / Q000473:pathology*