Deficient prepulse inhibition induced by selective breeding of rats can be restored by the dopamine D2 antagonist haloperidol.
Deficient sensorimotor gating, measured as prepulse inhibition (PPI) of startle, reflects disturbed information processing found in neuropsychiatric disorders. Examining the ability to selectively breed rats for high and low PPI, results showed significant differences of PPI scores within two generations. Comparing antipsychotics to restore PPI of the low group, haloperidol was shown more effective than clozapine. This suggests low PPI rats may be useful models for neuropsychiatric disorders and screening antipsychotics.
Hadamitzky
Martin
M
Brain Research Institute, Department of Neuropharmacology, University of Bremen, PO Box 33 04 40, 28334 Bremen, Germany. hadamitz@uni-bremen.de
Harich
Silke
S
Koch
Michael
M
Schwabe
Kerstin
K
D000161:Acoustic Stimulation / Q000379:methods; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001947:Breeding / Q000379:methods; D003024:Clozapine / Q000627:therapeutic use; D018492:Dopamine Antagonists / Q000627:therapeutic use*; D005260:Female; D020233:Gait Disorders, Neurologic / Q000188:drug therapy* / Q000235:genetics* / Q000503:physiopathology; D006220:Haloperidol / Q000627:therapeutic use*; D007266:Inhibition, Psychological; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013216:Reflex, Startle / Q000187:drug effects; D012702:Serotonin Antagonists / Q000627:therapeutic use; D012737:Sex Factors
D018492:Dopamine Antagonists; D012702:Serotonin Antagonists; D003024:Clozapine; D006220:Haloperidol