[Presbycusis: neural degeneration and aging on the auditory receptor of C57/BL6J mice].
Presbycusis is a progressive hearing impairment associated with aging, characterized by hearing loss and a degeneration of cochlear structures. In this paper we analyze the effects of aging on the auditory system of C57/BL6J mice, with electrophysiological and morphological studies. With this aim the auditory potentials of mice aging 1, 3, 6, 9, 12, 15, 18, 21 and 24 months were recorded, and then the morphology of the cochleal were analyzed. Auditory potentials revealed an increase in wave latencies, as well as a decrease in their amplitudes during aging. Morphological results showed a total Corti's organ degeneration, being replaced by a flat epithelial layer, and a total absence of hair cells.
Castillo
E
E
Laboratorio de Neurobiología de la Audición, Dpto. Oftalmología y Otorrinolaringología, Facultad de Medicina, Universidad Complutense de Madrid.
Carricondo
F
F
Bartolomé
M V
MV
Vicente-Torres
A
A
Poch Broto
J
J
Gil-Loyzaga
P
P
D000375:Aging / Q000502:physiology*; D000818:Animals; D003051:Cochlea / Q000473:pathology / Q000503:physiopathology; D005260:Female; D006198:Hair Cells, Auditory / Q000473:pathology / Q000503:physiopathology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009410:Nerve Degeneration / Q000150:complications* / Q000473:pathology / Q000503:physiopathology*; D011304:Presbycusis / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology*