Cytotoxic steroidal saponins from Polygonatum punctatum.
Four new steroidal saponins, polypunctosides A-D (1-4, resp.), were isolated from the rhizomes of Polygonatum punctatum, together with five known steroidal saponins. On the basis of chemical and spectral evidence, the structures of the new saponins were established as (3beta,23S,25R)-23-(alpha-L-arabinopyranosyloxy)spirost-5-en-3-yl 4-O-(6-deoxy-alpha-L-mannopyranosyl)-D-glucopyranoside (1), (3beta,23S,25R)-23-[(2-O-acetyl-alpha-L-arabinopyranosyl)oxy]spirost-5-en-3-yl 4-O-(6-deoxy-alpha-L-mannopyranosyl)-D-glucopyranoside (2), (3beta,23S,25R)-23-[(3-O-acetyl-alpha-L-arabinopyranosyl)oxy]spirost-5-en-3-yl 4-O-(6-deoxy-alpha-L-mannopyranosyl)-D-glucopyranoside (3), and (3beta,23S,25R)-23-[(4-O-acetyl-alpha-L-arabinopyranosyl)oxy]spirost-5-en-3-yl 4-O-(6-deoxy-alpha-L-mannopyranosyl)-D-glucopyranoside (4). The cytotoxic activity of the isolated saponins was evaluated towards HeLa cells.
Yang
Qing-Xiong
QX
College of Biotechnology and Bioengineering, Guizhou Normal University, 116 Baoshan North Road, Guiyang, 550001, PR China. yangqx@gznu.edu.cn
Yang
Chong-Ren
CR
D003603:Cytotoxins / Q000737:chemistry; D006367:HeLa Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D008956:Models, Chemical; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry / Q000378:metabolism; D031384:Polygonatum / Q000378:metabolism*; D012503:Saponins / Q000737:chemistry* / Q000494:pharmacology; D013256:Steroids / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry
D003603:Cytotoxins; D010936:Plant Extracts; D012503:Saponins; D013256:Steroids; D014315:Triterpenes