Synaptic mechanisms of synchronized gamma oscillations in inhibitory interneuron networks.
Gamma frequency oscillations are thought to provide a temporal structure for information processing in the brain. They contribute to cognitive functions, such as memory formation and sensory processing, and are disturbed in some psychiatric disorders. Fast-spiking, parvalbumin-expressing, soma-inhibiting interneurons have a key role in the generation of these oscillations. Experimental analysis in the hippocampus and the neocortex reveals that synapses among these interneurons are highly specialized. Computational analysis further suggests that synaptic specialization turns interneuron networks into robust gamma frequency oscillators.
Bartos
Marlene
M
Physiologisches Institut der Universität Freiburg, Abteilung 1, Hermann Herder Strasse 7, D-79104 Freiburg, Germany.
Vida
Imre
I
Jonas
Peter
P
D000818:Animals; D001921:Brain / Q000166:cytology; D006801:Humans; D007395:Interneurons / Q000502:physiology*; D009415:Nerve Net / Q000502:physiology*; D009433:Neural Inhibition; D016571:Neural Networks, Computer; D010507:Periodicity; D013569:Synapses / Q000502:physiology*