Serial sinus aspirate samples during high-dose, short-course levofloxacin treatment of acute maxillary sinusitis.
This study assessed daily aspirate samples from an indwelling sinus catheter during high-dose, short-course levofloxacin (750 mg daily x 5 days) treatment of acute maxillary sinusitis. Pathogens were isolated from 4 of 18 recruited patients. Bacteriologic eradication occurred within 24 h for 3 patients and 72 h for the 4th.
Anon
Jack B
JB
Department of Otolaryngology, University of Pittsburgh, College of Medicine, Erie, PA 16508, USA.
Paglia
Margaret
M
Xiang
Jim
J
Ambrose
Paul G
PG
Jones
Ronald N
RN
Kahn
James B
JB
D000208:Acute Disease; D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D002408:Catheters, Indwelling; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D006192:Haemophilus Infections / Q000188:drug therapy / Q000382:microbiology; D006193:Haemophilus influenzae / Q000187:drug effects / Q000302:isolation & purification; D006801:Humans; D064704:Levofloxacin; D008297:Male; D015523:Maxillary Sinusitis / Q000188:drug therapy* / Q000382:microbiology*; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D001936:Moraxella catarrhalis / Q000187:drug effects / Q000302:isolation & purification; D045828:Moraxellaceae Infections / Q000188:drug therapy / Q000382:microbiology; D015242:Ofloxacin / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D011008:Pneumococcal Infections / Q000188:drug therapy / Q000382:microbiology; D013296:Streptococcus pneumoniae / Q000187:drug effects / Q000302:isolation & purification; D013997:Time Factors; D016896:Treatment Outcome
D000900:Anti-Bacterial Agents; D064704:Levofloxacin; D015242:Ofloxacin