[Peculiarities of ion transport of calcium in tumor cells under conditions of irradiation by ionizing radiation, chemopreparations and homeopathic means].
The goal of given investigation was to reveal an effect of different agents on ion transport of Ca2+ in tumor cells (Erlich's carcinomas). Ionizing radiation, antitumor preparation vinkristin as well as homeopathic means - stimulated phosphoric acid diluted at 10-14 were used. Small doses of radiation (0,05 and 0,1 Gr) always had a stimulating effect on ion transport even in combination with vinkristin, which separately always depressed it. Both separately and in any combination stimulated phosphoric acid always reinforced transmembrane ion transport. In regard to Ca2+ a hypothesis about its participation in the process of reparation of tumor cell has been suggested. At increasing of Ca2+ concentrations a transmembrane transport of this ion in the environment increases what induces strengthening of adhesive properties of the cell. However, it is known that in tumors these properties are decreased. Apparently, in this case two contrary processes - strengthening and decrease of adhesive properties take place pointing to the fact that there appear reparative forces in tumor process.
Mikhvetadze
A V
AV
Nadateĭshvili
G G
GG
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000627:therapeutic use*; D002118:Calcium / Q000378:metabolism*; D002277:Carcinoma / Q000188:drug therapy / Q000378:metabolism* / Q000532:radiotherapy; D004305:Dose-Response Relationship, Drug; D004307:Dose-Response Relationship, Radiation; D006705:Homeopathy / Q000379:methods; D017136:Ion Transport / Q000187:drug effects* / Q000528:radiation effects*; D051379:Mice; D011839:Radiation, Ionizing; D014407:Tumor Cells, Cultured; D014750:Vincristine / Q000008:administration & dosage / Q000627:therapeutic use*
D000972:Antineoplastic Agents, Phytogenic; D014750:Vincristine; D002118:Calcium