[Action of estradiol, calcitonin and weight-loading on the development of osteopenia in tail-suspended female rats].
Experiments with tail-suspended female rats demonstrated that injection of sinestrol (synthesized estradiol) and myocalcic (sermon calcitonin) on a background of graded weight bearing (suspension interruption for 2 hrs. a day) prevented osteopenia in the spongy metaphyses of the shin-bone deprived of loading.
Grigor'ev
A I
AI
Durnova
G N
GN
Kaplanskiĭ
A S
AS
D000818:Animals; D050071:Bone Density Conservation Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001851:Bone Diseases, Metabolic / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D002116:Calcitonin / Q000008:administration & dosage / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004359:Drug Therapy, Combination; D004838:Epiphyses / Q000187:drug effects / Q000473:pathology; D004958:Estradiol / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D019417:Hindlimb Suspension / Q000009:adverse effects; D007273:Injections, Intramuscular; D051381:Rats; D017208:Rats, Wistar; D013977:Tibia / Q000187:drug effects / Q000473:pathology; D016896:Treatment Outcome; D016474:Weight-Bearing
D050071:Bone Density Conservation Agents; D004958:Estradiol; D002116:Calcitonin