title: A pair of novel cytotoxic polyprenylated xanthone epimers from gamboges.
abstract: Two new polyprenylated xanthone epimers were isolated from gamboges of Garcinia hanburyi, and identified by detailed spectroscopic analysis as 30-hydroxygambogic acid (2a) and its (2S)-epimer 30-hydroxyepigambogic acid (2b). Both compounds exhibited significant cytotoxicities against the human leukemia K562/S and the corresponding doxorubicin-resistant K562/R cell lines (Table 2).
authors.affiliation: Laboratory of Chinese Medicine, Hong Kong Jockey Club Institute of Chinese Medicine, Hong Kong, PR China.
authors.forename: Quan-Bin
authors.initials: QB
authors.lastname: Han
authors.forename: Ling
authors.initials: L
authors.lastname: Yang
authors.forename: Yu-Lin
authors.initials: YL
authors.lastname: Wang
authors.forename: Chun-Feng
authors.initials: CF
authors.lastname: Qiao
authors.forename: Jing-Zheng
authors.initials: JZ
authors.lastname: Song
authors.forename: Han-Dong
authors.initials: HD
authors.lastname: Sun
authors.forename: Hong-Xi
authors.initials: HX
authors.lastname: Xu
mesh_terms: D045744:Cell Line, Tumor; D003603:Cytotoxins / Q000737:chemistry / Q000302:isolation & purification*; D004365:Drugs, Chinese Herbal; D029760:Garcinia; D006801:Humans; D020014:K562 Cells; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification; D044004:Xanthones / Q000737:chemistry / Q000302:isolation & purification*
chemical_list: D003603:Cytotoxins; D004365:Drugs, Chinese Herbal; D010936:Plant Extracts; D044004:Xanthones