title: A treatment planning study comparing whole breast radiation therapy against conformal, IMRT and tomotherapy for accelerated partial breast irradiation.
abstract: OBJECTIVE
  Conventional early breast cancer treatment consists of a lumpectomy followed by whole breast radiation therapy. Accelerated partial breast irradiation (APBI) is an investigational approach to post-lumpectomy radiation for early breast cancer. The purpose of this study is to compare four external beam APBI techniques, including tomotherapy, with conventional whole breast irradiation for their radiation conformity index, dose homogeneity index, and dose to organs at risk.
  
  
  METHODS
  Small-field tangents, three-dimensional conformal radiation therapy, intensity-modulated radiation therapy and helical tomotherapy were compared for each of 15 patients (7 right, 8 left). One radiation conformity and two dose homogeneity indices were used to evaluate the dose to the target. The mean dose to organs at risk was also evaluated.
  
  
  RESULTS
  All proposed APBI techniques improved the conformity index significantly over whole breast tangents while maintaining dose homogeneity and without a significant increase in dose to organs at risk.
  
  
  CONCLUSIONS
  The four-field IMRT plan produced the best dosimetric results; however this technique would require appropriate respiratory motion management. An alternative would be to use a four-field conformal technique that is less sensitive to the effects of respiratory motion.
authors.affiliation: Department of Medical Biophysics, London Regional Cancer Program, London Health Sciences Centre, London, Canada. michael.oliver@lhsc.on.ca
authors.forename: Mike
authors.initials: M
authors.lastname: Oliver
authors.forename: Jeff
authors.initials: J
authors.lastname: Chen
authors.forename: Eugene
authors.initials: E
authors.lastname: Wong
authors.forename: Jake
authors.initials: J
authors.lastname: Van Dyk
authors.forename: Francisco
authors.initials: F
authors.lastname: Perera
mesh_terms: D001943:Breast Neoplasms / Q000532:radiotherapy* / Q000601:surgery; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D015412:Mastectomy, Segmental; D011878:Radiotherapy / Q000379:methods*; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted; D020266:Radiotherapy, Conformal; D050397:Radiotherapy, Intensity-Modulated; D036542:Tomography, Spiral Computed