title: The role of pineal gland and exogenous melatonin on the irradiation stress response of suprarenal gland.
abstract: Pineal gland has and antistressogenic role. Its main hormone, melatonin, has radio protective effect on endocrine and other dynamic tissues. In our previous study, we have shown that pinealectomy changes the behavior of suprarenal gland in totally irradiated rats. The aim of this study is to evaluate the effect of exogenous melatonin on suprarenal gland of rats with or without pineal gland. Four months after pinealectomy (experimental group) or shampinealectomy (control group), adult Wistar male rats were daily treated with 0,2 mg of melatonin intraperitoneally, during two weeks. Thereafter, all animals were totally irradiated with 8 Gy of Gamma rays produced from Cobalt 60. Animals who survived were sacrificed on the 17(th) post irradiation day. Qualitative and quantitative characteristics of the suprarenal gland were studied using histological methods. The results show that exogenous melatonin had protective role on suprarenal gland in totally irradiated rats and that those effects were more pronounced in the presence of pineal gland.
authors.affiliation: Institute for Histology and Embryology, Faculty of Medicine, University of Sarajevo, Cekalusa 90, 71000 Sarajevo, Bosnia and Herzegovina.
authors.forename: Selma
authors.initials: S
authors.lastname: Alicelebić
authors.forename: Zakira
authors.initials: Z
authors.lastname: Mornjaković
authors.forename: Irfan
authors.initials: I
authors.lastname: Susko
authors.forename: Esad
authors.initials: E
authors.lastname: Cosović
authors.forename: Amira
authors.initials: A
authors.lastname: Beganović-Petrović
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D005088:Exocrine Glands / Q000033:anatomy & histology / Q000187:drug effects / Q000528:radiation effects*; D005720:Gamma Rays; D007668:Kidney / Q000033:anatomy & histology / Q000502:physiology*; D008297:Male; D008550:Melatonin / Q000494:pharmacology*; D010870:Pineal Gland / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D013312:Stress, Physiological / Q000503:physiopathology*; D014916:Whole-Body Irradiation
chemical_list: D000975:Antioxidants; D008550:Melatonin