title: [Analysis of studies published on hypertension treatment non-compliance in Spain between 1984 and 2005].
abstract: OBJECTIVE
  To analyse therapy non-compliance in hypertension treatment in Spain, after a review of studies published between 1984 and 2005.
  
  
  METHODS
  Systematic review.
  
  
  METHODS
  Data searches used Internet (Medline and Spanish index on doctoral these), a manual search of several Spanish journals, and bibliographic references to compliance from detected articles and through personal contact with experts. Descriptors used were: hypertension and patient compliance, compliance, adherence, patient drop-outs, treatment refusal, and their combinations.
  
  
  METHODS
  Studies conducted in Spain and published between 1984 and 2005 were included, along with original articles, congress abstracts or doctoral theses, which used as a method of measurement pill count or counting of spaces in electronic monitoring systems, and which defined as non-compliers patients with a compliance percentage <80% and >110%.
  
  
  METHODS
  The percentage of non-compliers was calculated, with 95% confidence intervals and weighted average of the percentage of non-compliers in each study.
  
  
  RESULTS
  Twenty-six research studies published in Spain, excluding 2 analytical studies, were found. A total of 3553 patients with hypertension were included, of which 32.53% were non-compliers (n= 1156; 95 CI, 29.83-35.23) and 67.47% were compliers (n=2397; 95% CI, 65.67-69.27). The weighted average of non-compliance was at 32.78%.
  
  
  CONCLUSIONS
  The percentage of therapy non-compliance in the treatment of hypertension in Spain has fallen in recent years, although it continues to be high.
authors.affiliation: Centro de Salud La Orden, Huelva, Spain.
authors.forename: Emilio
authors.initials: E
authors.lastname: Márquez Contreras
authors.forename: Vicente
authors.initials: V
authors.lastname: Gil Guillén
authors.forename: José Joaquín
authors.initials: JJ
authors.lastname: Casado Martínez
authors.forename: Nieves
authors.initials: N
authors.lastname: Martel Claros
authors.forename: Mariano
authors.initials: M
authors.lastname: De la Figuera von Wichmann
authors.forename: José Luis
authors.initials: JL
authors.lastname: Martín de Pablos
authors.forename: Francisco
authors.initials: F
authors.lastname: Atienza Martín
authors.forename: Teresa
authors.initials: T
authors.lastname: Gros García
authors.forename: Jacinto
authors.initials: J
authors.lastname: Espinosa García
mesh_terms: D000959:Antihypertensive Agents / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D010349:Patient Compliance; D013030:Spain; D016312:Treatment Refusal
chemical_list: D000959:Antihypertensive Agents