title: Heart failure attenuates muscle metaboreflex control of ventricular contractility during dynamic exercise.
abstract: Underperfusion of active skeletal muscle elicits a reflex pressor response termed the muscle metaboreflex (MMR). In normal dogs during mild exercise, MMR activation causes large increases in cardiac output (CO) and mean arterial pressure (MAP); however, in heart failure (HF) although MAP increases, the rise in CO is virtually abolished, which may be due to an impaired ability to increase left ventricular contractility (LVC). The objective of the present study was to determine whether the increases in LVC seen with MMR activation during dynamic exercise in normal animals are abolished in HF. Conscious dogs were chronically instrumented to measure CO, MAP, and left ventricular (LV) pressure and volume. LVC was calculated from pressure-volume loop analysis [LV maximal elastance (E(max)) and preload-recruitable stroke work (PRSW)] at rest and during mild and moderate exercise under free-flow conditions and with MMR activation (via partial occlusion of hindlimb blood flow) before and after rapid ventricular pacing-induced HF. In control experiments, MMR activation at both workloads [mild exercise (3.2 km/h) and moderate exercise (6.4 km/h at 10% grade)] significantly increased CO, E(max), and PRSW. In contrast, after HF was induced, CO, E(max), and PRSW were significantly lower at rest. Although CO increased significantly from rest to exercise, E(max) and PRSW did not change. In addition, MMR activation caused no significant change in CO, E(max), or PRSW at either workload. We conclude that MMR causes large increases in LVC in normal animals but that this ability is abolished in HF.
authors.affiliation: Department of Physiology, Wayne State University School of Medicine, 540 East Canfield Avenue, Detroit, MI 48201, USA.
authors.forename: Javier A
authors.initials: JA
authors.lastname: Sala-Mercado
authors.forename: Robert L
authors.initials: RL
authors.lastname: Hammond
authors.forename: Jong-Kyung
authors.initials: JK
authors.lastname: Kim
authors.forename: Phillip J
authors.initials: PJ
authors.lastname: McDonald
authors.forename: Larry W
authors.initials: LW
authors.lastname: Stephenson
authors.forename: Donal S
authors.initials: DS
authors.lastname: O'Leary
mesh_terms: D000818:Animals; D001783:Blood Flow Velocity; D002303:Cardiac Output, Low / Q000150:complications / Q000503:physiopathology*; D004285:Dogs; D005260:Female; D008297:Male; D018482:Muscle, Skeletal / Q000098:blood supply* / Q000294:innervation / Q000503:physiopathology*; D009200:Myocardial Contraction; D005082:Physical Exertion; D012018:Reflex; D018487:Ventricular Dysfunction, Left / Q000209:etiology / Q000503:physiopathology*