DNA-protein interactions and bacterial chromosome architecture.
Bacteria, like eukaryotic organisms, must compact the DNA molecule comprising their genome and form a functional chromosome. Yet, bacteria do it differently. A number of factors contribute to genome compaction and organization in bacteria, including entropic effects, supercoiling and DNA-protein interactions. A gamut of new experimental techniques have allowed new advances in the investigation of these factors, and spurred much interest in the dynamic response of the chromosome to environmental cues, segregation, and architecture, during both exponential and stationary phases. We review these recent developments with emphasis on the multifaceted roles that DNA-protein interactions play.
Stavans
Joel
J
Department of Physics of Complex Systems, Weizmann Institute of Science, Rehovot, Israel.
Oppenheim
Amos
A
D001426:Bacterial Proteins / Q000378:metabolism*; D002876:Chromosomes, Bacterial / Q000737:chemistry / Q000502:physiology / Q000648:ultrastructure; D004269:DNA, Bacterial / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000378:metabolism*; D019277:Entropy
D001426:Bacterial Proteins; D004269:DNA, Bacterial; D004268:DNA-Binding Proteins