title: Does binge eating disorder alter cortisol secretion in obese women?
abstract: It is still poorly determined whether the presence of Binge Eating Disorder (BED) would alter cortisol secretion in obese patients. We aimed at investigating levels of salivary cortisol (SC) in patients with and without BED. Forty seven (47) obese women between 30 and 65 years old were sequentially selected to participate in the study. The diagnosis of BED was assessed according to the Structured Clinical Interview for DSM-IV. Binge Eating Scale (BES) was used to assess binge severity. A trend toward a negative correlation was observed between SC and body mass index in the whole sample (p=0.06). The presence of BED was not associated with increased levels of SC. In women without BED, SC levels correlated inversely with BMI (p=0.01). On the other hand, in women with BED, SC levels correlated significantly with BES (p=0.01). Although obesity is associated with decreased levels of cortisol, this relationship may be lost in patients with BED. In patients with BED, binge eating severity may be a more relevant regulator of cortisol secretion than obesity itself.
authors.affiliation: Obesity and Eating Disorders Group (GOTA) - Instituto Estadual de Diabetes e Endocrinologia (IEDE)/Instituto de Psiquiatria da Universidade Federal do Rio de Janeiro (IPUB/UFRJ), Rio de Janeiro, Brazil. wcoutinho@globo.com
authors.forename: Walmir F
authors.initials: WF
authors.lastname: Coutinho
authors.forename: Rodrigo O
authors.initials: RO
authors.lastname: Moreira
authors.forename: Camila
authors.initials: C
authors.lastname: Spagnol
authors.forename: Jose C
authors.initials: JC
authors.lastname: Appolinario
mesh_terms: D000328:Adult; D000368:Aged; D001823:Body Composition / Q000502:physiology; D015992:Body Mass Index; D001835:Body Weight / Q000502:physiology; D052018:Bulimia Nervosa / Q000097:blood* / Q000175:diagnosis / Q000523:psychology; D002940:Circadian Rhythm / Q000502:physiology; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D007406:Interview, Psychological; D008875:Middle Aged; D009765:Obesity / Q000097:blood* / Q000175:diagnosis / Q000523:psychology; D012463:Saliva / Q000378:metabolism
chemical_list: D006854:Hydrocortisone