Effect of complex phytoadaptogen on MPTP-induced Parkinson's syndrome in mice.
Oral administration of 10% solution of Phytomix-40 (multicomponent plant phytoadaptogen) to C57Bl/6 mice with MPTP-induced Parkinson's syndrome alleviated symptoms (oligokinesia and muscle rigidity), compensated for the deficiency of dopamine and its metabolites (DOPAC and homovanillic acid), and reduced the level of lipid peroxides in the striatum. In vitro Phytomix-40 in a concentration of 3.3 x 10(-2) g/liter exhibited a pronounced antioxidant effect (5-fold decreased MDA level in mouse brain homogenate in Fe(2+)-ascorbate-dependent LPO).
Bocharov
E V
EV
Laboratory of General Pathophysiology of Nervous System, Institute of Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow.
Kucheryanu
V G
VG
Kryzhanovskii
G N
GN
Bocharova
O A
OA
Kudrin
V S
VS
Belorustseva
S A
SA
D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D003342:Corpus Striatum / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism; D006719:Homovanillic Acid / Q000378:metabolism; D008054:Lipid Peroxides / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D009043:Motor Activity / Q000187:drug effects; D009127:Muscle Rigidity / Q000188:drug therapy / Q000473:pathology; D020734:Parkinsonian Disorders / Q000188:drug therapy* / Q000473:pathology; D010936:Plant Extracts / Q000494:pharmacology* / Q000627:therapeutic use*; D012701:Serotonin / Q000378:metabolism
D008054:Lipid Peroxides; C401831:PM 40; D010936:Plant Extracts; D015102:3,4-Dihydroxyphenylacetic Acid; D012701:Serotonin; D004298:Dopamine; D006719:Homovanillic Acid