title: Evaluation of pituitary macroadenomas with multidetector-row CT (MDCT): comparison with MR imaging.
abstract: BACKGROUND
  It is important to have information on cavernous sinus extension and bony destruction in pituitary macroadenomas before surgery, but magnetic resonance (MR) imaging cannot always depict them. In the present study we sought to determine whether multidetector-row computed tomography (MDCT) could provide preoperative information in addition to that provided by MR imaging in pituitary macroadenoma.
  
  
  METHODS
  The subjects comprised 33 consecutive patients (15 women, 18 men; mean age 50 years) with surgically proven macroadenoma. For MDCT, using the soft-tissue window and bone window, three orthogonal multiplanar reconstruction images were generated from venous-phase contrast-enhanced 0.5-mm isotropic voxel data. MDCT and MR images were evaluated with regard to: (1) clarity of tumor margins; (2) identification of the normal pituitary gland; (3) identification of erosion or destruction of the sellar floor; and (4) visualization of the adjacent optic pathways.
  
  
  RESULTS
  MDCT more clearly demonstrated the lateral tumor margin than MR imaging (P = 0.002). No significant differences in visualization of the normal pituitary gland were noted between MDCT and dynamic MR imaging (P = 0.7). MDCT more clearly demonstrated sellar floor erosion or destruction at the sphenoid sinus than MR imaging (P < 0.001). MR imaging was superior to MDCT for visualizing the adjacent optic pathways (P < 0.001).
  
  
  CONCLUSIONS
  MDCT is superior to MR imaging for assessing lateral tumor margin and the sellar floor at the sphenoid sinus. MDCT offers useful preoperative information in addition to that obtained from MR imaging.
authors.affiliation: Department of Diagnostic Imaging and Nuclear Medicine, Graduate School of Medicine, Kyoto University, Kyoto, 606-8507, Japan. mikiy@kuhp.kyoto-u.ac.jp
authors.forename: Yukio
authors.initials: Y
authors.lastname: Miki
authors.forename: Mitsunori
authors.initials: M
authors.lastname: Kanagaki
authors.forename: Jun A
authors.initials: JA
authors.lastname: Takahashi
authors.forename: Koichi
authors.initials: K
authors.lastname: Ishizu
authors.forename: Masayuki
authors.initials: M
authors.lastname: Nakagawa
authors.forename: Akira
authors.initials: A
authors.lastname: Yamamoto
authors.forename: Yasutaka
authors.initials: Y
authors.lastname: Fushimi
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Okada
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Mikuni
authors.forename: Ken-ichiro
authors.initials: K
authors.lastname: Kikuta
authors.forename: Nobuo
authors.initials: N
authors.lastname: Hashimoto
authors.forename: Kaori
authors.initials: K
authors.lastname: Togashi
mesh_terms: D000236:Adenoma / Q000175:diagnosis* / Q000000981:diagnostic imaging; D000293:Adolescent; D000328:Adult; D000368:Aged; D003287:Contrast Media; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D010911:Pituitary Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging; D018709:Statistics, Nonparametric; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D003287:Contrast Media