title: Comparison of radial versus femoral approach for percutaneous coronary interventions in octogenarians.
abstract: BACKGROUND
  The safety and efficacy of a radial approach for percutaneous coronary intervention (PCI) in octogenarians is not well established.
  
  
  METHODS
  To evaluate the benefits of a radial approach for preventing vascular complications after PCI, clinical, procedural, and outcome data were prospectively collected and compared for 228 octogenarians undergoing elective PCI either through a radial or a femoral approach.
  
  
  RESULTS
  Radial approach was associated with longer cannulation (3.1 +/- 2.9 vs. 2.0 +/- 2.0 min, P < 0.001) and fluoroscopy times (19.3 +/- 16.1 vs. 16.1 +/- 11.8 min, P = 0.04), greater utilization of contrast media (224 +/- 46 vs. 182 +/- 20 ml, P < 0.001) and higher crossover rate (11 vs 4%, P = 0.03) to alternate access site compared with the femoral approach. However, ambulation time (5.2 +/- 3.1 vs. 11.6 +/- 6.3 hr, P < 0.001), access site bleeding (4 vs. 14%, P = 0.007), hematoma (1 vs. 11%, P = 0.001) or any vascular complication (5 vs 26%, P = 0.001) were significantly reduced with a radial approach. Procedural success rates were equivalent with both approaches. Multivariate regression analysis identified radial approach (OR = 0.23; CI = 0.08, 0.65) as an independent negative predictor of postprocedural vascular complications.
  
  
  CONCLUSIONS
  Radial approach for PCI in octogenarians is technically challenging for the operator and exposes patients to greater volume of nephrotoxic contrast media. However, it results in early ambulation and significantly reduces vascular complications in this high risk population. These findings support a strategy of preprocedural risk assessment and use of radial approach for PCI in a select group of octogenarians to maximize benefits offered by this technique.
authors.affiliation: Terrence Donnelly Heart Center, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Ronen
authors.initials: R
authors.lastname: Jaffe
authors.forename: Tony
authors.initials: T
authors.lastname: Hong
authors.forename: Waseem
authors.initials: W
authors.lastname: Sharieff
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Chisholm
authors.forename: Michael J B
authors.initials: MJ
authors.lastname: Kutryk
authors.forename: Thierry
authors.initials: T
authors.lastname: Charron
authors.forename: Asim N
authors.initials: AN
authors.lastname: Cheema
mesh_terms: D000369:Aged, 80 and over; D015906:Angioplasty, Balloon, Coronary / Q000009:adverse effects / Q000379:methods*; D015331:Cohort Studies; D003287:Contrast Media / Q000009:adverse effects; D004434:Early Ambulation; D005260:Female; D005263:Femoral Artery / Q000000981:diagnostic imaging; D005471:Fluoroscopy; D006406:Hematoma / Q000209:etiology / Q000517:prevention & control; D006470:Hemorrhage / Q000209:etiology / Q000517:prevention & control; D006801:Humans; D007674:Kidney Diseases / Q000139:chemically induced; D016015:Logistic Models; D008297:Male; D016017:Odds Ratio; D018579:Patient Selection; D011446:Prospective Studies; D017534:Radial Artery / Q000000981:diagnostic imaging; D012042:Registries; D018570:Risk Assessment; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D003287:Contrast Media