NT-proBNP levels correlate with organ failure in septic patients: a preliminary report.
The aim of the study was to evaluate the relationship between N-terminal brain natriuretic propeptide (NT-proBNP) plasma concentrations and the severity of organ dysfunction assessed by the Sepsis-related Organ Failure Assessment (SOFA) score in septic patients


METHODS
NT-proBNP, SOFA score, and survival were evaluated in 20 consecutive septic patients. They were prospectively included in the study when the sepsis criteria according to the ACCP/SCCM definitions (modified by the Polish Working Group for Sepsis) were fulfilled. Blood serum NT-proBNP concentrations were determined in each patient at given time intervals and the severity of organ dysfunction was estimated according to the SOFA score. The first measurement was performed within 12 h after the patient's inclusion into the study, the second, third, and fourth at 12, 24, and 48 hours after the first, and then every 48 hours thereafter


RESULTS
The mean NT-proBNP concentration and the mean SOFA score were 140.80+/-84.65 pg/ml and 6.31+/-3.75 points, respectively. The correlation coefficient between NT-proBNP level and SOFA score was R=0.5164 (p<0.05). The mortality in the studied group was 30%.


CONCLUSIONS
NT-proBNP levels correlate with the severity of organ dysfunction as assessed by the SOFA score in septic patients.
Piechota
Mariusz
M
Department of Anesthesiology and Intensive Care Unit, Boleslaw Szarecki University Hospital No. 5 of the Medical University of Łódź, Poland.
Banach
Maciej
M
Irzmański
Robert
R
Piechota-Urbańska
Magdalena
M
Kowalski
Jan
J
Pawlicki
Lucjan
L
D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000097:blood* / Q000145:classification / Q000209:etiology / Q000401:mortality*; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D011446:Prospective Studies; D018805:Sepsis / Q000097:blood* / Q000150:complications / Q000401:mortality*; D015996:Survival Rate
D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain