A sorbicillinoid urea from an intertidal Paecilomyces marquandii.
A ureido Diels-Alder adduct of sorbicillinol 3 has been isolated from an intertidal marine Paecilomyces marquandii strain, in a screening for new natural products. The structure was determined by spectroscopic methods, and the relative stereochemistry was confirmed by molecular modeling. The absolute stereochemistry was deduced by comparison of the CD curves with those of known members of the bisorbicillinol family. This is the first report of the isolation of a ureido sorbicillinol derivative.
Cabrera
Gabriela M
GM
Departamento de Química Orgánica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pab. II, (1428) Buenos Aires, Argentina. gabyc@qo.fcen.uba.ar
Butler
Matías
M
Rodriguez
M Alejandra
MA
Godeas
Alicia
A
Haddad
Renato
R
Eberlin
Marcos N
MN
D003512:Cyclohexanones / Q000737:chemistry; D006572:Heterocyclic Compounds, Bridged-Ring / Q000737:chemistry* / Q000302:isolation & purification*; D015394:Molecular Structure; D010143:Paecilomyces / Q000737:chemistry*; D014508:Urea / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification
D003512:Cyclohexanones; D006572:Heterocyclic Compounds, Bridged-Ring; C516416:sorbicillinoid urea; C453419:sorbicillinol; D014508:Urea