title: [Impact of combined anesthesia using isoflurane on the development of adaptation mechanisms on changing ventilation conditions in thoracic surgery].
abstract: The paper deals with the effect of isoflurane (IF) as a component of combined anesthesia during thoracic interventions in the lateral position on the development of adaptation mechanisms to a change in artificial ventilation (AV) modes--from ventilation of both lungs to that of one lung (unilateral ventilation, ULV), long exposure to ULV and to a change from ULV to ventilation of both lungs. Eighteen patients at a high operation-anesthetic risk were examined. Measurements were made in 6 steps, including conditions in AV, exposure to ULV for 15-30, 55-60, and 80-120 minutes, AV after 20-min exposure to ULV, and at the end of surgery in the supine position. While analyzing the results, the authors made an important observation that IF has a property of preventing capillary formation in the ventilated portions, without impairing the mechanism of pulmonary hypoxic vasoconstriction in the area of atelectized alveoles. This contributed to the optimization of a ventilation-perfusion relationship and creates conditions for adequate oxygenation. The use of IF as a component of combined anesthesia during thoracic operations associated with a need for artificial unilateral ventilation in patients at a high operation-anesthetic risk created conditions for optimizing gas exchange and blood circulation at all stages of an operation and anesthesia.
authors.forename: M A
authors.initials: MA
authors.lastname: Vyzhigina
authors.forename: O S
authors.initials: OS
authors.lastname: Riabova
authors.forename: T Iu
authors.initials: TIu
authors.lastname: Kulagina
authors.forename: S G
authors.initials: SG
authors.lastname: Zhukova
authors.forename: V D
authors.initials: VD
authors.lastname: Parshin
authors.forename: V A
authors.initials: VA
authors.lastname: Sandrikov
authors.forename: A A
authors.initials: AA
authors.lastname: Buniatian
mesh_terms: D000222:Adaptation, Physiological / Q000187:drug effects*; D000328:Adult; D000368:Aged; D000758:Anesthesia / Q000379:methods*; D019162:Anesthetics, Combined / Q000008:administration & dosage*; D018685:Anesthetics, Inhalation / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007530:Isoflurane / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D012121:Respiration, Artificial / Q000379:methods; D016683:Supine Position; D019616:Thoracic Surgical Procedures
chemical_list: D019162:Anesthetics, Combined; D018685:Anesthetics, Inhalation; D007530:Isoflurane