title: Acute Myelogeneous Leukemia (M0/M1) with novel chromosomal abnormality of t(14;17) (q32; q11.2).
abstract: Acute Myelogeneous Leukemia (AML) is a heterogeneous disease with respect to morphology, immunophenotype, and genetic rearrangements. Multiple recurrent chromosomal aberrations have been identified by conventional cytogenetic analysis. In this study, we report a case whose clinical features were suggestive of AML-M1 subtype with t(14;17) (q32; q11.2) karyotype involving rearrangement of chromosomal segments 17q11.2 and 14q32. This is the first report of novel chromosomal translocation in this subset of AML and has not yet been reported elsewhere. This rearrangement may include certain cancer associated oncogene(s) or genes involved in the differentiation like retionic acid receptor alpha (RARA), which may confer differentiation blockage and/or proliferation advantage.
authors.affiliation: Cancer Cytogenetic Division, SRL Ranbaxy Limited, MIDC, Mumbai, India.
authors.forename: Firoz
authors.initials: F
authors.lastname: Ahmad
authors.forename: Rupa
authors.initials: R
authors.lastname: Dalvi
authors.forename: Swarna
authors.initials: S
authors.lastname: Mandava
authors.forename: Bibhu Ranjan
authors.initials: BR
authors.lastname: Das
mesh_terms: D000328:Adult; D002883:Chromosomes, Human, Pair 14 / Q000235:genetics*; D002886:Chromosomes, Human, Pair 17 / Q000235:genetics*; D005260:Female; D006801:Humans; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000235:genetics* / Q000473:pathology; D014178:Translocation, Genetic / Q000235:genetics*