Regulation, cell differentiation and protein-based inheritance.
Recent research using fungi as models provide new insight into the ability of regulatory networks to generate cellular states that are sufficiently stable to be faithfully transmitted to daughter cells, thereby generating epigenetic inheritance. Such protein-based inheritance is driven by infectious factors endowed with properties usually displayed by prions. We emphasize the contribution of regulatory networks to the emerging properties displayed by cells.
Malagnac
Fabienne
F
Institut de Génétique et Microbiologie, Université de Paris, Paris, France.
Silar
Philippe
P
D002454:Cell Differentiation; D044127:Epigenesis, Genetic; D005656:Fungal Proteins / Q000235:genetics* / Q000378:metabolism; D015966:Gene Expression Regulation, Fungal; D020935:MAP Kinase Signaling System; D008954:Models, Biological; D008957:Models, Genetic; D011328:Prions / Q000378:metabolism; D015398:Signal Transduction
D005656:Fungal Proteins; D011328:Prions