Does Abeta 42 have a function related to blood homeostasis?
In this review, I discuss the possibility that Abeta42 has a physiologic function in blood vessel homeostasis and the consequences that this might have for theories concerning the pathogenesis of Alzheimer's disease and for treatment.
Hardy
John
J
Laboratory of Neurogenetics, National Institute on Aging, Porter Neuroscience Building, NIH Main Campus, Bethesda, MD 20892, USA. hardyj@mail.nih.gov
D000544:Alzheimer Disease / Q000503:physiopathology; D016229:Amyloid beta-Peptides / Q000097:blood* / Q000502:physiology*; D000818:Animals; D001777:Blood Coagulation / Q000502:physiology; D001790:Blood Physiological Phenomena; D001808:Blood Vessels / Q000502:physiology*; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D007501:Iron / Q000378:metabolism; D010446:Peptide Fragments / Q000097:blood* / Q000502:physiology*; D053763:Presenilins / Q000235:genetics; D013569:Synapses / Q000187:drug effects; D016875:tau Proteins / Q000235:genetics / Q000502:physiology
D016229:Amyloid beta-Peptides; D010446:Peptide Fragments; D053763:Presenilins; C075222:amyloid beta-protein (1-42); D016875:tau Proteins; D007501:Iron