Bone marrow transplantation for leukocyte adhesion deficiency-I: case report.
Leukocyte adhesion deficiency type I (LAD-I) is a rare autosomal recessive immunodeficiency syndrome leading to recurrent bacterial and fungal infections. Bone marrow transplantation offers the only cure. In this report, we describe the course and outcome of bone marrow transplant in a 4 month-old female infant with LAD-I at King Hussein Medical Center, Jordan. A successful matched HLA- related allogeneic bone marrow transplantation was performed. Engraftment was demonstrated on the 12th day. The patient developed Grade III grafts versus host disease (GVHD), veno-occlusive disease of the liver, and late onset hemorrhagic cystitis. She recovered with appropriate immune reconstitution.
Al-wahadneh
Adel Mohammed
AM
Bone Marrow Transplantation Unit, King Hussein Medical Center, Royal Medical Services, Amman, Jordan. awah88@hotmail.com
Haddadin
Issam
I
Hamouri
Mufeed
M
Omari
Khalifah
K
Aejellat
Faten
F
D016026:Bone Marrow Transplantation; D003556:Cystitis; D005260:Female; D005808:Genes, Recessive; D006086:Graft vs Host Disease; D006470:Hemorrhage; D006504:Hepatic Veno-Occlusive Disease; D006801:Humans; D007223:Infant; D018370:Leukocyte-Adhesion Deficiency Syndrome / Q000235:genetics / Q000601:surgery*; D011183:Postoperative Complications; D016896:Treatment Outcome