Frequent methamphetamine use is associated with primary non-nucleoside reverse transcriptase inhibitor resistance.
We determined whether methamphetamine use is associated with the increased prevalence of primary HIV drug resistance among a cohort of men who have sex with men recently infected with HIV. In multivariate analysis, we found that frequent methamphetamine use was strongly associated with primary non-nucleoside reverse transcriptase inhibitor resistance, but not with protease inhibitor or nucleoside reverse transcriptase inhibitor resistance. We postulate that this association may be caused by methamphetamine-associated treatment interruptions among source partners.
Colfax
Grant Nash
GN
AIDS Office, San Francisco Department of Public Health, San Francisco, California, USA.
Vittinghoff
Eric
E
Grant
Robert
R
Lum
Paula
P
Spotts
Gerald
G
Hecht
Frederick M
FM
D000328:Adult; D019380:Anti-HIV Agents / Q000494:pharmacology*; D003430:Cross-Sectional Studies; D024882:Drug Resistance, Viral; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy / Q000635:transmission / Q000821:virology; D015497:HIV-1 / Q000187:drug effects*; D018451:Homosexuality, Male; D006801:Humans; D008297:Male; D008694:Methamphetamine; D018894:Reverse Transcriptase Inhibitors / Q000494:pharmacology; D019966:Substance-Related Disorders / Q000150:complications*
D019380:Anti-HIV Agents; D018894:Reverse Transcriptase Inhibitors; D008694:Methamphetamine