[Carbamazepine intoxication. Complication of alcohol detoxification with combined carbamazepine and tiapride].
The advantages of alcohol detoxification treatment with combined carbamazepine and tiapride compared to benzodiazepines or clomethiazole is a lower level of sedation and lack of addictive potential. We report a case of carbamazepine intoxication with serum levels up to 19 mg/l in an otherwise healthy 45-year-old alcohol-dependent male after treatment with 600 mg carbamazepine and 600 mg tiapride per day. Medication was discontinued immediately and a purgative was administered. We were able to combat the intoxication but the assumed good tolerance of the combined treatment with carbamazepine and tiapride for alcohol detoxification still has to be proven.
Diehl
A
A
Klinik für Abhängiges Verhalten und Suchtmedizin, Zentralinstitut für Seelische Gesundheit Mannheim, Universität Heidelberg I 5, 68159 Mannheim. alexander.diehl@zi-mannheim.de
Grosshans
M
M
Herre
H
H
Croissant
B
B
Mann
K
K
D000437:Alcoholism / Q000150:complications / Q000534:rehabilitation*; D000927:Anticonvulsants / Q000008:administration & dosage / Q000506:poisoning; D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000009:adverse effects; D002220:Carbamazepine / Q000008:administration & dosage* / Q000506:poisoning*; D004359:Drug Therapy, Combination; D000431:Ethanol / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013375:Substance Withdrawal Syndrome / Q000188:drug therapy*; D013976:Tiapamil Hydrochloride / Q000008:administration & dosage*
D000927:Anticonvulsants; D014150:Antipsychotic Agents; D002220:Carbamazepine; D000431:Ethanol; D013976:Tiapamil Hydrochloride