[The application and research advances of Brucella vaccines].
Brucellosis is a crucial zoonosis caused by Brucella, which has some traits of wide hosts, great infectivity and difficulty in cure. Brucellosis caused great losses to farming and people's health. Vaccination is the main measure used to control Brucellosis, and some attenuated Brucella strains were often used as vaccines. To find more effective vaccines, Scientists are now constructing recombinant strains, DNA vaccines and subunit vaccines, as well as inducing new attenuated strains from isolations. The present applications of B. abortus strain 19 (S19) , B. melitensis Rev. 1 (Rev. 1), B. suis strain 2 (S2), B. abortus strain 45/20 (45/20) and rough strain B. abortus 51 (RB51) were discussed. And some recent research work on Brucella vaccines, such as Brucella recombinant vaccines, DNA vaccines and so on, were reviewed in this paper.
Ding
Jia-Bo
JB
China Institute of Veterinary Drug Control, Beijing 100081, China. dingjiabo@sohu.com
Mao
Kai-Rong
KR
Cheng
Jun-Sheng
JS
Dai
Zhi-Hong
ZH
Jiang
Yu-Wen
YW
D000818:Animals; D002004:Brucella Vaccine / Q000276:immunology*; D006801:Humans; D011994:Recombinant Proteins / Q000276:immunology; D014613:Vaccines, Attenuated / Q000276:immunology; D019444:Vaccines, DNA / Q000276:immunology; D014614:Vaccines, Synthetic / Q000276:immunology
D002004:Brucella Vaccine; D011994:Recombinant Proteins; D014613:Vaccines, Attenuated; D019444:Vaccines, DNA; D014614:Vaccines, Synthetic