title: Favourable outcome in an APL patient with PLZF/RARalpha fusion gene: quantitative real-time RT-PCR confirms molecular response.
abstract: Rare cases of acute promyelocytic leukemia (APL) are associated with a t(11;17) translocation and a PLZF-RARalpha fusion transcript. Because of molecular specificities of the fusion protein, ATRA efficiency is often reduced in these cases. We present herein the case of an 83-year old patient which has been successfully treated by ATRA and Daunorubicin. The described quantitative RT-PCR method allowed successful monitoring and confirmation of the molecular response.
authors.affiliation: Unité de Biologie Cellulaire, Hopital Saint-Louis, 1 avenue Claude Vellefaux, 75010 Paris, France. bruno.cassinat@sls.aphp.fr
authors.forename: Bruno
authors.initials: B
authors.lastname: Cassinat
authors.forename: Isabelle
authors.initials: I
authors.lastname: Guillemot
authors.forename: Cécile
authors.initials: C
authors.lastname: Moluçon-Chabrot
authors.forename: Fabien
authors.initials: F
authors.lastname: Zassadowski
authors.forename: Pierre
authors.initials: P
authors.lastname: Fenaux
authors.forename: Olivier
authors.initials: O
authors.lastname: Tournilhac
authors.forename: Christine
authors.initials: C
authors.lastname: Chomienne
mesh_terms: D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000032:analysis / Q000235:genetics; D001853:Bone Marrow / Q000737:chemistry / Q000473:pathology; D002884:Chromosomes, Human, Pair 15 / Q000235:genetics / Q000648:ultrastructure; D002886:Chromosomes, Human, Pair 17 / Q000235:genetics / Q000648:ultrastructure; D003199:Computer Systems; D003630:Daunorubicin / Q000008:administration & dosage; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000188:drug therapy / Q000235:genetics*; D015122:Mercaptopurine / Q000008:administration & dosage; D008727:Methotrexate / Q000008:administration & dosage; D009363:Neoplasm Proteins / Q000032:analysis / Q000235:genetics*; D015514:Oncogene Proteins, Fusion / Q000032:analysis / Q000235:genetics*; D012074:Remission Induction; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014178:Translocation, Genetic; D014212:Tretinoin / Q000008:administration & dosage
chemical_list: D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins; D015514:Oncogene Proteins, Fusion; C118318:PLZF-RARalpha fusion protein, human; D014212:Tretinoin; D015122:Mercaptopurine; D008727:Methotrexate; D003630:Daunorubicin