title: Collagen shields as a drug delivery system for the fourth-generation fluoroquinolones.
abstract: OBJECTIVE
  To evaluate the penetration of commercially available gatifloxacin and moxifloxacin into the anterior chamber of a rabbit eye using collagen shields presoaked in the antibiotics as a drug delivery system.
  
  
  METHODS
  Collagen shields, presoaked for 10 min in commercially available solutions of gatifloxacin (diluted intravenous Tequin) or moxifloxacin (Vigamox) with the same concentration, were placed on the surface of each of the corneas of 12 rabbits for a total of 24 eyes (12 in each group). Aqueous humor samples were taken 3 and 6 h later.
  
  
  RESULTS
  The concentrations of both antibiotics were high after 3 h (3.1 +/- 1.3 microg/ml for moxifloxacin and 2.3 +/- 0.8 microg/ml for gatifloxacin, p = 0.22). The concentration of gatifloxacin after 6 h was statistically significantly higher than for moxifloxacin (0.76 +/- 0.33 microg/ml vs. 0.29 + 0.14 microg/ml, respectively, p = 0.03).
  
  
  CONCLUSIONS
  Our results suggest that collagen shields can be effective as a drug delivery system for the fourth-generation fluoroquinolones with a longer effect for gatifloxacin.
authors.affiliation: Department of Ophthalmology and Visual Sciences, John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, USA. guy.kleinmann@hsc.utah.edu
authors.forename: Guy
authors.initials: G
authors.lastname: Kleinmann
authors.forename: Scott
authors.initials: S
authors.lastname: Larson
authors.forename: Brian
authors.initials: B
authors.lastname: Hunter
authors.forename: Scott
authors.initials: S
authors.lastname: Stevens
authors.forename: Nick
authors.initials: N
authors.lastname: Mamalis
authors.forename: Randall J
authors.initials: RJ
authors.lastname: Olson
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics; D001082:Aqueous Humor / Q000378:metabolism; D001372:Aza Compounds / Q000008:administration & dosage* / Q000493:pharmacokinetics; D001682:Biological Availability; D001684:Biological Dressings; D002851:Chromatography, High Pressure Liquid; D003094:Collagen; D016503:Drug Delivery Systems; D024841:Fluoroquinolones / Q000008:administration & dosage* / Q000493:pharmacokinetics; D000077734:Gatifloxacin; D008297:Male; D000077266:Moxifloxacin; D011804:Quinolines / Q000008:administration & dosage* / Q000493:pharmacokinetics; D011817:Rabbits
chemical_list: D000890:Anti-Infective Agents; D001372:Aza Compounds; D024841:Fluoroquinolones; D011804:Quinolines; D003094:Collagen; D000077734:Gatifloxacin; D000077266:Moxifloxacin