title: Molecular study of genes involved in virulence regulatory pathways in Bacillus anthracis vaccine strain "Carbosap".
abstract: This study investigated the genetic bases of attenuation in the Bacillus anthracis vaccine strain "Carbosap" used in Italy against anthrax in cattle and sheep. Twelve genes involved in virulence regulatory pathways underwent sequence analysis in comparison with a B. anthracis virulent strain.
authors.affiliation: Istituto Superiore di Sanità, Environmental and Primary Prevention Department, Viale Regina Elena 299, 00161, Rome, Italy. giuseppina.larosa@iss.it
authors.forename: Giuseppina
authors.initials: G
authors.lastname: La Rosa
authors.forename: Michele
authors.initials: M
authors.lastname: Muscillo
authors.forename: Michela
authors.initials: M
authors.lastname: Sali
authors.forename: Elena
authors.initials: E
authors.lastname: De Carolis
authors.forename: Cinzia
authors.initials: C
authors.lastname: Marianelli
authors.forename: Franco
authors.initials: F
authors.lastname: Ciuchini
authors.forename: Antonio
authors.initials: A
authors.lastname: Fasanella
authors.forename: Rosanna
authors.initials: R
authors.lastname: Adone
mesh_terms: D000818:Animals; D000881:Anthrax / Q000382:microbiology / Q000517:prevention & control / Q000662:veterinary; D022122:Anthrax Vaccines; D001408:Bacillus anthracis / Q000145:classification / Q000235:genetics / Q000276:immunology / Q000472:pathogenicity*; D001426:Bacterial Proteins / Q000235:genetics*; D002417:Cattle; D015964:Gene Expression Regulation, Bacterial; D007558:Italy; D016133:Polymerase Chain Reaction / Q000379:methods; D017422:Sequence Analysis, DNA; D012756:Sheep; D014613:Vaccines, Attenuated; D014774:Virulence; D037521:Virulence Factors / Q000235:genetics*
chemical_list: D022122:Anthrax Vaccines; D001426:Bacterial Proteins; D014613:Vaccines, Attenuated; D037521:Virulence Factors