Grabbing Plk1 by the PBD.
A new centromeric protein termed PBIP1 was identified that recruits Plk1 to the kinetochores. In the November 3 issue of Molecular Cell, show that Plk1 phosphorylates PBIP1 on threonine 78, creating its own high-affinity docking site for the polo-box domain (PBD).
Dai
Wei
W
Department of Environmental Medicine, New York University School of Medicine, Tuxedo, New York 10987, USA.
Wang
Xiaoxing
X
D018797:Cell Cycle Proteins / Q000378:metabolism*; D002503:Centromere / Q000378:metabolism*; D018386:Kinetochores / Q000378:metabolism*; D008954:Models, Biological; D010766:Phosphorylation; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D011518:Proto-Oncogene Proteins / Q000378:metabolism*; D000097869:Polo-Like Kinase 1
D018797:Cell Cycle Proteins; D017346:Protein Serine-Threonine Kinases; D011518:Proto-Oncogene Proteins; D000097869:Polo-Like Kinase 1