Association between a polymorphism in the promoter region of the TPH2 gene and the personality trait of harm avoidance.
In a genetic association study the role of the -703 G/T (rs4570625) polymorphism, located in the promoter region of the tryptophan hydroxylase 2 gene (TPH2), in personality traits was investigated in a sample of 404 healthy Caucasian subjects. A significant association between harm avoidance (HA), a trait related to anxiety, and the -703 G/T polymorphism was detected supporting the findings by Gutknecht and colleagues.
Reuter
Martin
M
Center of Psychobiology and Behavioral Medicine, Department of Psychology, Justus-Liebig University of Giessen, Otto-Behaghel-Strasse 10F, D-35394 Giessen, Germany. martin.reuter@psychol.uni-giessen.de
Kuepper
Yvonne
Y
Hennig
Juergen
J
D000328:Adult; D000375:Aging / Q000523:psychology; D000483:Alleles; D001007:Anxiety / Q000523:psychology; D004247:DNA / Q000235:genetics; D004644:Emotions / Q000502:physiology; D005106:Exploratory Behavior / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D010551:Personality / Q000235:genetics* / Q000502:physiology*; D010556:Personality Tests; D011110:Polymorphism, Genetic / Q000235:genetics; D011401:Promoter Regions, Genetic / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012201:Reward; D012727:Sex Characteristics; D013694:Temperament; D014365:Tryptophan Hydroxylase / Q000235:genetics*
D004247:DNA; C494784:TPH2 protein, human; D014365:Tryptophan Hydroxylase