title: First-degree relative history of alcoholism in eating disorder inpatients: relationship to eating and substance use psychopathology.
abstract: OBJECTIVE
  We examined the influence of family history of alcoholism on the presentation and course of inpatients with eating disorders (ED) by comparing ED behaviors, substance abuse behaviors, and psychopathology of patients with alcoholic first-degree relatives (AFDR+) to those without alcoholic first-degree relatives (AFDR-).
  
  
  METHODS
  Female inpatients admitted to a specialty eating disorders service completed demographic, family history, behavioral, and psychological questionnaires (N=217). Body mass index (BMI) at admission and discharge, length of stay, and rates of weight gain were calculated.
  
  
  RESULTS
  AFDR+ participants did not differ from AFDR- participants diagnostically, but AFDR+ participants did report higher lifetime frequencies of several ED and substance abuse behaviors. Measures of ED psychopathology and personality vulnerability were also elevated in the AFDR+ group.
  
  
  CONCLUSIONS
  ED inpatients with a first-degree family history of alcoholism demonstrate increased psychopathology in eating behavior, substance use, and personality vulnerability domains. While the genetic diathesis for alcoholism is likely distinct from that for eating disorders, these findings suggest that first-degree relative history of alcoholism may nevertheless exert a negative influence on eating disorder behaviors.
authors.affiliation: Johns Hopkins University School of Medicine, Department of Psychiatry and Behavioral Sciences, Phipps 315, 600 N. Wolfe St., Baltimore, MD 21287, USA. gwr@jhmi.edu
authors.forename: Graham W
authors.initials: GW
authors.lastname: Redgrave
authors.forename: Janelle W
authors.initials: JW
authors.lastname: Coughlin
authors.forename: Leslie J
authors.initials: LJ
authors.lastname: Heinberg
authors.forename: Angela S
authors.initials: AS
authors.lastname: Guarda
mesh_terms: D000293:Adolescent; D000328:Adult; D000437:Alcoholism / Q000453:epidemiology / Q000235:genetics* / Q000523:psychology; D000856:Anorexia Nervosa / Q000453:epidemiology / Q000235:genetics* / Q000523:psychology; D015992:Body Mass Index; D052018:Bulimia Nervosa / Q000453:epidemiology / Q000235:genetics* / Q000523:psychology; D002648:Child; D015897:Comorbidity; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D007902:Length of Stay / Q000706:statistics & numerical data; D008875:Middle Aged; D010343:Patient Admission / Q000706:statistics & numerical data; D010555:Personality Inventory; D012307:Risk Factors; D019966:Substance-Related Disorders / Q000453:epidemiology / Q000235:genetics* / Q000523:psychology; D015430:Weight Gain