Chromatin looping mediates boundary element promoter interactions.
One facet of the control of gene expression is long-range promoter regulation by distant enhancers. It is an important component of the regulation of genes that control metazoan development and has been appreciated for some time but the molecular mechanisms underlying this regulation have remained poorly understood. A recent study by Cleard and colleagues1 reports the first in vivo evidence of chromatin looping and boundary element promoter interaction. Specifically, they studied the function of a boundary element within the cis-regulatory region of the Abdominal-B (Abd-B) gene of Drosophila melanogaster.
Celniker
Susan E
SE
Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA. celniker@bdgp.lbl.gov
Drewell
Robert A
RA
D000818:Animals; D030801:Animals, Genetically Modified; D042002:Chromatin Assembly and Disassembly / Q000235:genetics*; D029721:Drosophila Proteins / Q000235:genetics; D004331:Drosophila melanogaster / Q000235:genetics; D005786:Gene Expression Regulation; D017344:Genes, Insect; D018398:Homeodomain Proteins / Q000235:genetics; D008957:Models, Genetic; D011401:Promoter Regions, Genetic
C062393:Abd-B proteins, Drosophila; D029721:Drosophila Proteins; D018398:Homeodomain Proteins