Continuous subcutaneous insulin infusion (CSII) in children with type 1 diabetes.
Recent studies have shown that continuous subcutaneous insulin infusion (CSII), or insulin pump therapy, provides a treatment option that can assist in the attainment of current goals of treatment in children and adolescents with type 1 diabetes (T1DM). In pediatric patients, CSII has been demonstrated to reduce both glycosylated hemoglobin levels and frequency of severe hypoglycemia, without sacrifices in safety, quality of life, or excessive weight gain, particularly in conjunction with the use of new insulin analogs and improvements in pump technology. Clinical studies of safety and efficacy of CSII in children are reviewed.
Tamborlane
William V
WV
Department of Pediatrics and General Clinical Research Center, Yale University School of Medicine, New Haven, CT, USA. WilliamTamborlane@yale.edu
Sikes
Kristin A
KA
Steffen
Amy T
AT
Weinzimer
Stuart A
SA
D000293:Adolescent; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000188:drug therapy*; D006801:Humans; D007332:Insulin Infusion Systems; D015203:Reproducibility of Results; D012449:Safety; D016896:Treatment Outcome