title: The combined effects of alpha-tocopheryl acetate supplementation and enrofloxacin administration on oxidative stability of turkey meat.
abstract: 1. The combined effects of dietary supplementation of vitamin E and enrofloxacin administration on the oxidative stability of turkey meat were assessed. 2. Enrofloxacin concentrations found in muscles and liver samples from turkeys receiving 200 g/kg of alpha-tocopheryl acetate plus 50 mg/kg of enrofloxacin without a withdrawal period were higher than those of samples administered with 50 mg/kg of enrofloxacin alone. Similarly, meat samples from turkeys receiving 50 mg/kg of enrofloxacin with withdrawal plus 200 mg/kg of alpha-tocopheryl acetate showed a significantly lower vitamin E accumulation than meat samples of the treatment with enrofloxacin without withdrawal plus vitamin E. 3. The results indicated an interaction between the antioxidant and the antibiotic in their effects on oxidation susceptibility and the abiotic safety of meat from turkeys fed on supplemented diets. A mutual stabilisation of both compounds by reducing the effects of free radicals or by affecting the absorption of the compounds is suggested.
authors.affiliation: Institut de Recerca I Tecnologia (IRTA), Centre de Tecnologia de la Carn, Granja Camps i Armet s/n, E-17121 Monells, Girona, Spain. carmen.sarraga@irta.es
authors.forename: C
authors.initials: C
authors.lastname: Sárraga
authors.forename: I
authors.initials: I
authors.lastname: Carreras
authors.forename: J A
authors.initials: JA
authors.lastname: García Regueiro
authors.forename: M
authors.initials: M
authors.lastname: Castellari
mesh_terms: D000821:Animal Feed / Q000032:analysis; D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D000900:Anti-Bacterial Agents / Q000378:metabolism / Q000494:pharmacology*; D002939:Ciprofloxacin / Q000032:analysis / Q000378:metabolism; D004032:Diet / Q000662:veterinary; D019587:Dietary Supplements; D004350:Drug Residues / Q000032:analysis; D000077422:Enrofloxacin; D024841:Fluoroquinolones / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology*; D007501:Iron; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000737:chemistry; D008460:Meat / Q000032:analysis / Q000592:standards*; D010084:Oxidation-Reduction / Q000187:drug effects; D013997:Time Factors; D024505:Tocopherols; D014422:Turkeys; D024502:alpha-Tocopherol / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones; D000077422:Enrofloxacin; D002939:Ciprofloxacin; D007501:Iron; D024502:alpha-Tocopherol; D024505:Tocopherols