Immune response and immunotherapy to Cryptococcus infections.
Cryptococcus neoformans is a ubiquitous fungus that can cause lifethreatening infections during immunosuppressive states such as acquired immunodeficiency syndrome (AIDS) and after bone marrow transplantation (BMT). Infected individuals normally succumb to meningitis and meningoencephalitis caused by dissemination of C. neoformans to the brain. In this review, we analyze the current understanding of the interaction between host immune response and C. neoformans as well as the current state of immunotherapeutic strategies for treating cryptococcosis.
Zhou
Qing
Q
Department of Microbiology and Immunology, University of Nevada, Reno, NV 89557, USA.
Murphy
William J
WJ
D000818:Animals; D000935:Antifungal Agents / Q000627:therapeutic use; D003453:Cryptococcosis / Q000276:immunology* / Q000628:therapy*; D003455:Cryptococcus neoformans / Q000276:immunology*; D006801:Humans; D007167:Immunotherapy / Q000379:methods*
D000935:Antifungal Agents