[Use of average-acting nondepolarizing myorelaxants in abdominal surgery].
The efficiency and safety of use of average-acting nondepolarizing myorelaxants, such as atracurium, vecuronuim, rocuronium, and cisatracurum, during abdominal surgical interventions under general anesthesia (combined or total intravenous anesthesia) were investigated in 162 patients. There is evidence that the use of the above agents ensures a qualitative myorelaxation during different types of operations (laparoscopic and laparotomic) and no impact on hemodynamics (according to the data of continuous non-invasive monitoring) allows these myorelaxants to be used in patients with concomitant cardiovascular diseases. Rocuronium is the myorelaxant of choice for rapid tracheal intubation. The high degree of predictability of the duration of an effect produced by atracurium and cisatracurium enables these myorelaxants to be used without monitoring neuromuscular conduction. With the equally good quality of myoplegia and with virtually comparable consumed diseases, the infusion procedure of relaxation maintenance is preferable for early activation of patients. Insignificant effects on histamine release make it possible to use vecuronium, rocuronium, and cisatracurium in patients with the compromised immune system.
Deshko
Iu V
IuV
Mizikov
V M
VM
Stamov
V I
VI
Golovkin
A S
AS
Vinitskiĭ
L I
LI
D000005:Abdomen / Q000601:surgery*; D000768:Anesthesia, General; D000771:Anesthesia, Intravenous; D002319:Cardiovascular System / Q000187:drug effects; D005260:Female; D006632:Histamine / Q000097:blood; D006801:Humans; D008297:Male; D003473:Neuromuscular Nondepolarizing Agents / Q000008:administration & dosage* / Q000009:adverse effects
D003473:Neuromuscular Nondepolarizing Agents; D006632:Histamine