title: New benzopyran-based openers of the mitochondrial ATP-sensitive potassium channel with potent anti-ischemic properties.
abstract: This study was aimed at evaluating, on a limited number of benzopyran compounds, whether the insertion of an electron-rich spirocyclic substituent at the C4 carbon of the benzopyran molecular nucleus may improve the cardioprotective properties against ischemia. Some of the new compounds (1b, 2b, and 4b) exhibited interesting anti-ischemic properties without affecting significantly the blood pressure parameters.
authors.affiliation: Dipartimento di Scienze Farmaceutiche and Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, Università di Pisa, Via Bonanno 6, I-56126 Pisa, Italy.
authors.forename: Maria C
authors.initials: MC
authors.lastname: Breschi
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Calderone
authors.forename: Alma
authors.initials: A
authors.lastname: Martelli
authors.forename: Filippo
authors.initials: F
authors.lastname: Minutolo
authors.forename: Simona
authors.initials: S
authors.lastname: Rapposelli
authors.forename: Lara
authors.initials: L
authors.lastname: Testai
authors.forename: Federica
authors.initials: F
authors.lastname: Tonelli
authors.forename: Aldo
authors.initials: A
authors.lastname: Balsamo
mesh_terms: D000255:Adenosine Triphosphate / Q000494:pharmacology*; D000818:Animals; D001011:Aorta / Q000187:drug effects; D001578:Benzopyrans / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D002316:Cardiotonic Agents / Q000494:pharmacology*; D007511:Ischemia / Q000188:drug therapy*; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008929:Mitochondria, Heart / Q000187:drug effects* / Q000378:metabolism; D015428:Myocardial Reperfusion Injury / Q000188:drug therapy*; D015221:Potassium Channels / Q000187:drug effects*; D051381:Rats; D014664:Vasodilation / Q000187:drug effects
chemical_list: D001578:Benzopyrans; D002316:Cardiotonic Agents; D015221:Potassium Channels; D000255:Adenosine Triphosphate; D007770:L-Lactate Dehydrogenase