title: Asarum sieboldii extracts attenuate growth, acid production, adhesion, and water-insoluble glucan synthesis of Streptococcus mutans.
abstract: Asarum sieboldii has been used in traditional folk medicine to treat dental caries and periodontal disease. In the present study, we investigated the inhibitory effect of the ethanol and aqueous extracts of A. sieboldii on the growth, acid production, adhesion, and water-insoluble glucan synthesis of Streptococcus mutans. The ethanol and aqueous extracts of A. sieboldii inhibited the growth and acid production of S. mutans. In the bacterial adherence assay, the ethanol and aqueous extracts of A. sieboldii significantly lowered the adherence of S. mutans. We also found that the ethanol and aqueous extracts of A. sieboldii significantly inhibited the synthesis of water-insoluble glucan by crude glucosyltransferase. These results suggest that A. sieboldii extracts may inhibit the caries-inducing properties of S. mutans. Further studies are necessary to clarify the active constituents of A. sieboldii extracts responsible for such biomolecular activities.
authors.affiliation: Department of Food and Nutrition, Kunsan National University, Kunsan, Republic of Korea.
authors.forename: Hyeon-Hee
authors.initials: HH
authors.lastname: Yu
authors.forename: Se-Jeong
authors.initials: SJ
authors.lastname: Seo
authors.forename: Jong-Moon
authors.initials: JM
authors.lastname: Hur
authors.forename: Heung-Soo
authors.initials: HS
authors.lastname: Lee
authors.forename: Young-Eun
authors.initials: YE
authors.lastname: Lee
authors.forename: Yong-Ouk
authors.initials: YO
authors.lastname: You
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D030023:Asarum / Q000737:chemistry*; D001422:Bacterial Adhesion / Q000187:drug effects*; D004791:Enzyme Inhibitors / Q000494:pharmacology; D000431:Ethanol; D005936:Glucans / Q000096:biosynthesis*; D005964:Glucosyltransferases / Q000037:antagonists & inhibitors / Q000378:metabolism; D010936:Plant Extracts / Q000494:pharmacology*; D012995:Solubility; D013295:Streptococcus mutans / Q000187:drug effects* / Q000254:growth & development / Q000502:physiology; D014867:Water
chemical_list: D000900:Anti-Bacterial Agents; D004791:Enzyme Inhibitors; D005936:Glucans; D010936:Plant Extracts; D014867:Water; D000431:Ethanol; D005964:Glucosyltransferases