[Effect of Bufei Qingyu Granule in mollifying skin of mouse scleroderma model].
OBJECTIVE
To investigate the effect and mechanism of Bufei Qingyu Granule (BQG) in mollifying the skin of scleroderma model mice.


METHODS
Scleroderma model induced with bleomycin in BALB/C mice 8-weeks old were administered with different dose of BQG for 26 days. The pathological changes of the mice skin were observed.


RESULTS
Treatment with low, medium and high dose of BQG showed a tendency to ameliorate the thickened dermis in scleroderma mice but without statistical significance. Medium and high dose of BQG reduced the perivasculitis of dermis and alleviated the reduction or deletion of accessory structure, such as hair follicle and sweat gland. And the spleen index was lower markedly in mice treated with BQG of any dose than that in the untreated model mice (P < 0.05).


CONCLUSIONS
BQG could ameliorate the sclerosed skin in model mice and prevent the occurrence of splenomegaly.
Qian
Xian
X
Jiangsu Provincial Hospital of Traditional Chinese Medicine, Nanjing. moneyfirst1@yahoo.com.cn
Zhu
Xuan-xuan
XX
Chen
Xiao-yong
XY
D000818:Animals; D001761:Bleomycin; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008517:Phytotherapy; D011897:Random Allocation; D012594:Scleroderma, Localized / Q000139:chemically induced / Q000188:drug therapy*; D012867:Skin / Q000187:drug effects* / Q000473:pathology; D013997:Time Factors
D004365:Drugs, Chinese Herbal; C527658:bufei quingyu; D001761:Bleomycin