Nodular regenerative hyperplasia is a new cause of chronic liver disease in HIV-infected patients.
OBJECTIVE
To describe and explain the syndrome of HIV-associated cryptogenic liver disease in eight consecutive patients suffering from portal hypertension.


METHODS
The study was undertaken at a liver disease centre in Paris and involved eight of 97 consecutive HIV-infected patients presenting abnormal liver function tests and/or symptomatic portal hypertension of unknown origin. Serology, pathology, and liver function tests were performed.


RESULTS
A clear nodular architecture corresponding to nodular regenerative hyperplasia was observed in seven patients and suggested in one, based on the presence of sinusoidal dilatation in a clinical context of portal hypertension, without overt liver disease.


CONCLUSIONS
Nodular regenerative hyperplasia appears to be a new cause of portal hypertension in HIV-infected patients. This syndrome can be of critical importance as patients can be exposed to the significant complications of portal hypertension and to refractory ascites which may require liver transplantation.
Mallet
Vincent
V
Université Paris-Descartes, France.
Blanchard
Pierre
P
Verkarre
Virginie
V
Vallet-Pichard
Anaïs
A
Fontaine
Hélène
H
Lascoux-Combe
Caroline
C
Pol
Stanislas
S
D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D002908:Chronic Disease; D005260:Female; D020518:Focal Nodular Hyperplasia / Q000150:complications / Q000473:pathology / Q000628:therapy / Q000821:virology*; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy / Q000276:immunology; D006801:Humans; D006975:Hypertension, Portal / Q000209:etiology; D008297:Male; D008875:Middle Aged
D019380:Anti-HIV Agents