Isolation and characterisation of a phenolic impurity in a commercial sample of duloxetine.
A phenolic impurity of duloxetine hydrochloride was isolated and characterised (MS, NMR, X-ray-analysis).
Brenna
Elisabetta
E
Dipartimento di Chimica, Materiali, Ingegneria Chimica, Politecnico di Milano, ed Istituto CNR per la Chimica del Riconoscimento Molecolare, Via Mancinelli 7, I-20131 Milano, Italy. elisabetta.brenna@polimi.it
Frigoli
Samuele
S
Fronza
Giovanni
G
Fuganti
Claudio
C
Malpezzi
Luciana
L
D004340:Drug Contamination; D000068736:Duloxetine Hydrochloride; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry / Q000379:methods; D015394:Molecular Structure; D019800:Phenol / Q000032:analysis / Q000737:chemistry / Q000302:isolation & purification*; D017367:Selective Serotonin Reuptake Inhibitors / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization; D013876:Thiophenes / Q000737:chemistry*
D000068736:Duloxetine Hydrochloride; D019800:Phenol; D017367:Selective Serotonin Reuptake Inhibitors; D013876:Thiophenes