title: Aging, B lymphopoiesis, and patterns of leukemogenesis.
abstract: The production of B lymphocytes begins to decline steadily early in adult life and is severely compromised in the elderly. This occurrence has been attributed to intrinsic defects in early hematopoietic progenitors and B cell precursors as well as to microenvironmental changes in aged bone marrow. The aim of this review is to present an overview of B lymphocyte senescence and its underlying causes and to discuss its impact on immune function and leukemogenesis in aged individuals.
authors.affiliation: Department of Pathology and Laboratory Medicine and Hematopoietic Malignancies Program, Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
authors.forename: Robert A J
authors.initials: RA
authors.lastname: Signer
authors.forename: Encarnacion
authors.initials: E
authors.lastname: Montecino-Rodriguez
authors.forename: Kenneth
authors.initials: K
authors.lastname: Dorshkind
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging / Q000502:physiology*; D001402:B-Lymphocytes / Q000502:physiology*; D006801:Humans; D007231:Infant, Newborn; D007938:Leukemia / Q000503:physiopathology*; D038041:Lymphopoiesis / Q000502:physiology*