The relationship between previous fluoroquinolone use and levofloxacin resistance in Helicobacter pylori infection.
The relationship between prior fluoroquinolone use and levofloxacin resistance in Helicobacter pylori infection is unknown. Among 125 enrolled patients, 8.8% had H. pylori isolates that were resistant to levofloxacin. Levofloxacin resistance was associated with any prior fluoroquinolone use over the previous 10 years and with the total number of fluoroquinolone courses prescribed (P<.001).
Carothers
John J
JJ
Native Medical Center, Anchorage, Alaska, USA.
Bruce
Michael G
MG
Hennessy
Thomas W
TW
Bensler
Michael
M
Morris
Julie M
JM
Reasonover
Alisa L
AL
Hurlburt
Debby A
DA
Parkinson
Alan J
AJ
Coleman
John M
JM
McMahon
Brian J
BJ
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D024901:Drug Resistance, Multiple, Bacterial; D005260:Female; D016481:Helicobacter Infections / Q000188:drug therapy* / Q000382:microbiology*; D016480:Helicobacter pylori / Q000187:drug effects*; D006801:Humans; D064704:Levofloxacin; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D015242:Ofloxacin / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D064704:Levofloxacin; D015242:Ofloxacin