Two novel glycosidic triterpene alkaloids from the stem barks of Machilus yaoshansis.
[structure: see text] Two unusual glycosidic triterpene alkaloids, machilaminosides A (1) and B (2), have been isolated from the stem barks of Machilus yaoshansis. Their structures were elucidated by detailed spectroscopic analysis. A possible biogenetic origin of 1 and 2 mediated by the coupling of 2-O-beta-D-glucopyranosyl-cucurbitacin I, respectively, with urea and adenosine was postulated. 1 and 2 showed nonselective cytotoxic activities against several human cancer cell lines as well as TNF-alpha secretion inhibitory activities.
Liu
Ming-Tao
MT
Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Beijing, People's Republic of China.
Lin
Sheng
S
Wang
Ying-Hong
YH
He
Wen-Yi
WY
Li
Shuai
S
Wang
Su-Juan
SJ
Yang
Yong-Chun
YC
Shi
Jian-Gong
JG
D000470:Alkaloids / Q000096:biosynthesis / Q000737:chemistry*; D006027:Glycosides / Q000096:biosynthesis / Q000737:chemistry*; D019770:Lauraceae / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D024301:Plant Bark / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry*
D000470:Alkaloids; D006027:Glycosides; D014315:Triterpenes; C517122:machilaminoside A; C517121:machilaminoside B