title: Yaequinolones, new insecticidal antibiotics produced by Penicillium sp. FKI-2140. I. Taxonomy, fermentation, isolation and biological activity.
abstract: New nine insecticidal antibiotics designated yaequinolones were isolated from the culture broth of the fungal strain Penicillium sp. FKI-2140 by solvent extraction, centrifugal partition chromatography and HPLC. Yaequinolones showed growth inhibitory activity against brine shrimp (Artemia salina). Among them, yaequinolone F has the most potent activity with MIC value of 0.19 microg/ml.
authors.affiliation: School of Pharmacy, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan.
authors.forename: Ryuji
authors.initials: R
authors.lastname: Uchida
authors.forename: Rie
authors.initials: R
authors.lastname: Imasato
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Yamaguchi
authors.forename: Rokuro
authors.initials: R
authors.lastname: Masuma
authors.forename: Kazuro
authors.initials: K
authors.lastname: Shiomi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Tomoda
authors.forename: Satoshi
authors.initials: S
authors.lastname: Omura
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D001156:Artemia / Q000187:drug effects; D005285:Fermentation; D007306:Insecticides / Q000302:isolation & purification / Q000378:metabolism* / Q000494:pharmacology*; D007814:Larva / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D010407:Penicillium / Q000145:classification* / Q000378:metabolism*; D015363:Quinolones / Q000145:classification / Q000302:isolation & purification / Q000378:metabolism* / Q000494:pharmacology*; D013172:Spores, Fungal / Q000648:ultrastructure
chemical_list: D000900:Anti-Bacterial Agents; D007306:Insecticides; D015363:Quinolones