title: Quinoline derivative MC1626, a putative GCN5 histone acetyltransferase (HAT) inhibitor, exhibits HAT-independent activity against Toxoplasma gondii.
abstract: We report that quinoline derivative MC1626, first described as an inhibitor of the histone acetyltransferase (HAT) GCN5, is active against the protozoan parasite Toxoplasma gondii in vitro. However, MC1626 does not inhibit Toxoplasma GCN5 HATs or reduce HAT-mediated activity; rather, this quinoline may target the plastid organelle called the apicoplast.
authors.affiliation: Department of Pharmacology & Toxicology, IU Center For AIDS Research, Indiana University School of Medicine, 635 Barnhill Drive, MS A-525, Indianapolis, IN 46202, USA.
authors.forename: Aaron T
authors.initials: AT
authors.lastname: Smith
authors.forename: Meredith R
authors.initials: MR
authors.lastname: Livingston
authors.forename: Antonello
authors.initials: A
authors.lastname: Mai
authors.forename: Patrizia
authors.initials: P
authors.lastname: Filetici
authors.forename: Sherry F
authors.initials: SF
authors.lastname: Queener
authors.forename: William J
authors.initials: WJ
authors.lastname: Sullivan
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D051548:Histone Acetyltransferases / Q000037:antagonists & inhibitors*; D015388:Organelles / Q000187:drug effects; D011804:Quinolines / Q000494:pharmacology*; D012441:Saccharomyces cerevisiae / Q000201:enzymology; D014122:Toxoplasma / Q000187:drug effects* / Q000201:enzymology*; D000099224:p300-CBP-Associated Factor
chemical_list: D000981:Antiprotozoal Agents; D004791:Enzyme Inhibitors; D051548:Histone Acetyltransferases; D011804:Quinolines; C504219:MC1626; C037219:quinoline; C501179:KAT2A protein, human; D000099224:p300-CBP-Associated Factor