title: A view to a kill: structure of the RNA exosome.
abstract: The exosome is a 3' to 5' exoribonuclease central to many cellular processes, including mRNA decay. now present the biochemical reconstitution and crystal structure of the eukaryotic exosome. This remarkable achievement provides key insights into the composition and assembly of the human and yeast exosomes, revealing functions of individual subunits.
authors.affiliation: Rutgers University, Department of Cell Biology and Neuroscience, 604 Allison Road, Piscataway, NJ 08854, USA.
authors.forename: Vincent
authors.initials: V
authors.lastname: Shen
authors.forename: Megerditch
authors.initials: M
authors.lastname: Kiledjian
mesh_terms: D001105:Archaea / Q000737:chemistry; D018360:Crystallography, X-Ray; D005095:Exoribonucleases / Q000737:chemistry*; D006801:Humans; D008958:Models, Molecular; D046912:Multiprotein Complexes; D011487:Protein Conformation; D020871:RNA Stability; D015003:Yeasts / Q000737:chemistry
chemical_list: D046912:Multiprotein Complexes; D005095:Exoribonucleases