title: Elevated soluble CD30 correlates with development of bronchiolitis obliterans syndrome following lung transplantation.
abstract: BACKGROUND
  The long-term function of lung transplants is limited by chronic rejection (bronchiolitis obliterans syndrome, BOS). Due to lack of specific markers, BOS is diagnosed clinically. Because there is strong evidence that alloimmunity plays a significant role in the pathogenesis of BOS, we investigated whether soluble CD30 (sCD30), a T-cell activation marker, would correlate with BOS.
  
  
  METHODS
  Sera collected serially from BOS+ (n = 20) and matched BOS- (n = 20) lung transplant (LT) patients were analyzed for sCD30 by enzyme-linked immunosorbent assay. Pretransplant sera and sera from normal donors were also analyzed.
  
  
  RESULTS
  PreLT levels were comparable to normal subjects. However, posttransplant there was a significant elevation in sCD30 levels during BOS development in all BOS+ patients, compared to BOS- (mean 139.8+/-10.7 vs. 14.8+/-2.7 U/ml, P < 0.001). sCD30 levels declined in the BOS+ patients but were still elevated compared to BOS- (48.52+/-5.04 vs. 7.19+/-2.9, P < 0.0001).
  
  
  CONCLUSIONS
  We conclude that sCD30 may represent a novel marker to monitor the development of BOS.
authors.affiliation: Department of Surgery, Washington University School of Medicine, St. Louis, MO, USA.
authors.forename: Ryan C
authors.initials: RC
authors.lastname: Fields
authors.forename: Ankit
authors.initials: A
authors.lastname: Bharat
authors.forename: Nancy
authors.initials: N
authors.lastname: Steward
authors.forename: Aviva
authors.initials: A
authors.lastname: Aloush
authors.forename: Brian F
authors.initials: BF
authors.lastname: Meyers
authors.forename: Elbert P
authors.initials: EP
authors.lastname: Trulock
authors.forename: William C
authors.initials: WC
authors.lastname: Chapman
authors.forename: G Alexander
authors.initials: GA
authors.lastname: Patterson
authors.forename: Thalachallour
authors.initials: T
authors.lastname: Mohanakumar
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D001989:Bronchiolitis Obliterans / Q000175:diagnosis*; D005260:Female; D006084:Graft Rejection / Q000175:diagnosis*; D006801:Humans; D017730:Ki-1 Antigen / Q000097:blood*; D016040:Lung Transplantation; D008297:Male; D008875:Middle Aged; D012995:Solubility; D013577:Syndrome
chemical_list: D015415:Biomarkers; D017730:Ki-1 Antigen