title: Improvement of the synthetic tri-peptide vaccine (S3Pvac) against porcine Taenia solium cysticercosis in search of a more effective, inexpensive and manageable vaccine.
abstract: Vaccination of pigs may curtail Taenia solium transmission by reducing the number of cysticerci, the precursors of adult intestinal tapeworms in humans. Several antigen preparations induce protection against porcine cysticercosis in experimental settings but only one subunit vaccine (S3Pvac) has been tested and proved effective in the field against naturally acquired disease. Besides improving of the vaccine's effectiveness, significant reductions in production costs and in the logistics of its administration are necessary for the feasibility of nationwide control programs. This review highlights the development of several versions of S3Pvac aimed to increase effectiveness, reduce costs and increase feasibility by novel delivery systems and alternative routes of administration.
authors.affiliation: Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, México, D.F. 04510, Mexico. edda@servidor.unam.mx
authors.forename: Edda
authors.initials: E
authors.lastname: Sciutto
authors.forename: Gabriela
authors.initials: G
authors.lastname: Rosas
authors.forename: Marisela
authors.initials: M
authors.lastname: Hernández
authors.forename: Julio
authors.initials: J
authors.lastname: Morales
authors.forename: Carmen
authors.initials: C
authors.lastname: Cruz-Revilla
authors.forename: Andrea
authors.initials: A
authors.lastname: Toledo
authors.forename: Karen
authors.initials: K
authors.lastname: Manoutcharian
authors.forename: Goar
authors.initials: G
authors.lastname: Gevorkian
authors.forename: Abel
authors.initials: A
authors.lastname: Blancas
authors.forename: Gonzalo
authors.initials: G
authors.lastname: Acero
authors.forename: Beatriz
authors.initials: B
authors.lastname: Hernández
authors.forename: Jacquelynne
authors.initials: J
authors.lastname: Cervantes
authors.forename: Raul J
authors.initials: RJ
authors.lastname: Bobes
authors.forename: Fernando A
authors.initials: FA
authors.lastname: Goldbaum
authors.forename: Mirna
authors.initials: M
authors.lastname: Huerta
authors.forename: Alicia
authors.initials: A
authors.lastname: Diaz-Orea
authors.forename: Agnes
authors.initials: A
authors.lastname: Fleury
authors.forename: Aline S
authors.initials: AS
authors.lastname: de Aluja
authors.forename: Jose Luis
authors.initials: JL
authors.lastname: Cabrera-Ponce
authors.forename: Luis
authors.initials: L
authors.lastname: Herrera-Estrella
authors.forename: Gladis
authors.initials: G
authors.lastname: Fragoso
authors.forename: Carlos
authors.initials: C
authors.lastname: Larralde
mesh_terms: D000818:Animals; D003551:Cysticercosis / Q000469:parasitology / Q000517:prevention & control / Q000635:transmission / Q000662:veterinary*; D013552:Swine; D013553:Swine Diseases / Q000276:immunology / Q000469:parasitology / Q000517:prevention & control* / Q000635:transmission; D041201:Taenia solium / Q000276:immunology*; D014611:Vaccination / Q000191:economics / Q000379:methods / Q000662:veterinary*; D022223:Vaccines, Subunit / Q000191:economics / Q000276:immunology / Q000627:therapeutic use*; D014614:Vaccines, Synthetic / Q000191:economics / Q000276:immunology / Q000627:therapeutic use
chemical_list: D022223:Vaccines, Subunit; D014614:Vaccines, Synthetic