title: Is early age-related macular degeneration associated with cerebral MRI changes? The Atherosclerosis Risk in Communities study.
abstract: OBJECTIVE
  To examine the relation of early age-related macular degeneration (AMD) with cerebral magnetic resonance imaging (MRI) changes.
  
  
  METHODS
  Population-based, cross-sectional study.
  
  
  METHODS
  A sample of 1,684 persons ages 51 to 72 years with no history of stroke had cerebral MRI and retinal photography. MRI scans were graded for severity of white matter lesions (WML), sulcal widening (SW), and ventricular enlargement (VE). AMD was graded from retinal photographs.
  
  
  RESULTS
  After adjustment for age, gender, race, or center, early AMD (5.0% of participants) was not significantly associated with WML (odds ratio [OR] 1.0, 95% confidence intervals [CI], 0.6 to 1.6), SW (OR 0.6, 95% CI, 0.4 to 1.2), or VE (OR 1.0, 95% CI, 0.6 to 1.8).
  
  
  CONCLUSIONS
  These data showed no statistically significant association of early AMD with cerebral MRI changes, but the study was limited by a small number of cases with wide CIs. Further studies may clarify these associations.
authors.affiliation: Centre for Eye Research Australia, University of Melbourne, 32 Gisborne Street, Victoria 3002, Australia.
authors.forename: Andrea
authors.initials: A
authors.lastname: Grosso
authors.forename: Thomas H
authors.initials: TH
authors.lastname: Mosley
authors.forename: Ronald
authors.initials: R
authors.lastname: Klein
authors.forename: David J
authors.initials: DJ
authors.lastname: Couper
authors.forename: Gabriella
authors.initials: G
authors.lastname: Tikellis
authors.forename: Tien Y
authors.initials: TY
authors.lastname: Wong
mesh_terms: D000368:Aged; D001284:Atrophy; D001921:Brain / Q000473:pathology*; D001927:Brain Diseases / Q000150:complications* / Q000175:diagnosis; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008268:Macular Degeneration / Q000150:complications* / Q000175:diagnosis; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010781:Photography; D015995:Prevalence; D012160:Retina / Q000473:pathology*; D012307:Risk Factors