Filoviruses and the balance of innate, adaptive, and inflammatory responses.
The Filoviruses Marburg virus and Ebola virus are among the deadliest of human pathogens, causing fulminant hemorrhagic fevers typified by overmatched specific immune responses and profuse inflammatory responses. Keys to both vaccination and treatment may reside, first, in the understanding of immune dysfunctions that parallel Filoviral disease and, second, in devising ways to redirect and restore normal immune function as well as to mitigate inflammation. Here, we describe how Filoviral infections may subvert innate immune responses through perturbances of dendritic cells and neutrophils, with particular emphasis on the downstream effects on adaptive immunity and inflammation. We suggest that pivotal events may be subject to therapeutic intervention as Filoviruses encounter immune processes.
Mohamadzadeh
Mansour
M
US Army Medical Research Institute for Infectious Diseases, Frederick, MD 21702, USA. mansour.mohamadzadeh@det.amedd.army.mil
Chen
Lieping
L
Olinger
Gene G
GG
Pratt
William D
WD
Schmaljohn
Alan L
AL
D003713:Dendritic Cells / Q000276:immunology; D016563:Filoviridae / Q000276:immunology*; D018702:Filoviridae Infections / Q000276:immunology* / Q000503:physiopathology / Q000628:therapy; D006801:Humans; D007113:Immunity, Innate; D007249:Inflammation / Q000276:immunology / Q000503:physiopathology; D009504:Neutrophils / Q000276:immunology; D014765:Viral Vaccines / Q000627:therapeutic use
D014765:Viral Vaccines