Comparative analysis of human masculinity.
To study rapidly evolving male specific Y (MSY) genes we retrieved and analyzed nine such genes. VCY, HSFY and RBMY were found to have functional X gametologs, but the rest did not. Using chimpanzee orthologs for XKRY, CDY, HSFY, PRY, and TSPY, the average silent substitution is estimated as 0.017 +/- 0.006/site and the substitution rate is 1.42 x 10(-9)/site/year. Except for VCY, all other loci possess two or more pseudogenes on the Y chromosome. Sequence differences from functional genes show that BPY2, DAZ, XKRY, and RBMY each have one pseudogene for each one that is human specific, while others were generated well before the human-chimpanzee split, by means of duplication, retro-transposition or translocation. Some functional MSY gene duplication of VCY, CDY and HSFY, as well as X-linked VCX and HSFX duplication, occurred in the lineage leading to humans; these duplicates have accumulated nucleotide substitutions that permit their identification.
Bhowmick
B K
BK
School of Advanced Sciences, The Graduate University for Advanced Studies, Kanagawa, Japan. bejon@soken.ac.jp
Takahata
N
N
Watanabe
M
M
Satta
Y
Y
D000818:Animals; D004268:DNA-Binding Proteins / Q000235:genetics; D019143:Evolution, Molecular; D000076249:Heat Shock Transcription Factors; D006801:Humans; D008297:Male; D009687:Nuclear Proteins / Q000235:genetics; D002679:Pan troglodytes; D011544:Pseudogenes / Q000235:genetics*; D016601:RNA-Binding Proteins / Q000235:genetics; D012727:Sex Characteristics; D014157:Transcription Factors / Q000235:genetics; D014998:Y Chromosome / Q000235:genetics*
D004268:DNA-Binding Proteins; D000076249:Heat Shock Transcription Factors; D009687:Nuclear Proteins; C501499:RBMY1A1 protein, human; D016601:RNA-Binding Proteins; D014157:Transcription Factors