[Isoniazid intoxication].
METHODS
A 55-year-old woman presented with sustained convulsions after the ingestion of an at first unknown amount of isoniazid, rifampin, ethambutol and alcohol.


METHODS
At admission the patient had a severe metabolic acidosis. Blood tests showed changes caused by the hepatotoxicity of isoniazid.


METHODS
Because diazepam was not efficacious in controlling the convulsions the patient was intubated. In response to the therapautic measures the convulsions stopped and metabolic acidosis was quickly compensated. Pyridoxine was given intravenously as an antidote.


CONCLUSIONS
The rare intoxication with isoniazid demands immediate administration of pyridoxine and aggressive treatment of the convulsions.
Graf
J
J
Medizinische Klinik I, SLK-Kliniken Heilbronn GmbH, Klinikum am Gesundbrunnen, 74078 Heilbronn.
Scheffold
N
N
Radunz
W
W
Cyran
J
J
D000138:Acidosis / Q000139:chemically induced* / Q000188:drug therapy; D000927:Anticonvulsants / Q000627:therapeutic use; D000931:Antidotes / Q000008:administration & dosage; D000995:Antitubercular Agents / Q000506:poisoning*; D003975:Diazepam / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D007538:Isoniazid / Q000506:poisoning*; D008875:Middle Aged; D011736:Pyridoxine / Q000008:administration & dosage; D012008:Recurrence; D012640:Seizures / Q000139:chemically induced* / Q000188:drug therapy; D013406:Suicide, Attempted; D014803:Vitamin B Complex / Q000008:administration & dosage
D000927:Anticonvulsants; D000931:Antidotes; D000995:Antitubercular Agents; D014803:Vitamin B Complex; D011736:Pyridoxine; D003975:Diazepam; D007538:Isoniazid