Didanosine, lamivudine-emtricitabine and efavirenz as initial therapy in naive patients.
There are currently several suitable and different antiretroviral regimens to start highly active antiretroviral therapy (HAART), and many clinicians and patients prefer once-daily therapy. The efficacy and potency of efavirenz (EFV) has been established in many clinical trials and cohort studies; its pharmacokinetics, allowing for a convenient once-daily administration, make EFV one of the first agents to be included in once-daily regimens in naive patients. The two nucleoside reverse transcriptase inhibitors (NRTIs) accompanying the third drug have become the central skeleton, or the 'backbone' of the therapeutic scheme. Among the different NRTI pairs, a didanosine-lamivudine (3TC) or emtricitabine backbone for combination antiretroviral therapy may be a good option compared with any current NRTI-combinations due to its security, tolerance and once-daily dose. In this article, we review the advantages and drawbacks of didanosine-XTC-EFV as the initial regimen of HAART in HIV-infected patients.
Palacios
Rosario
R
Unidad de Enfermedades Infecciosas, Hospital Virgen de la Victoria, Málaga, 29010, Spain. med000854@saludalia.com
Aguilar
Isabel
I
Hidalgo
Ana
A
Santos
Jesús
J
D000480:Alkynes; D019380:Anti-HIV Agents / Q000191:economics / Q000592:standards / Q000627:therapeutic use*; D023241:Antiretroviral Therapy, Highly Active / Q000191:economics / Q000592:standards; D048588:Benzoxazines; D003521:Cyclopropanes; D003841:Deoxycytidine / Q000031:analogs & derivatives / Q000191:economics / Q000592:standards / Q000627:therapeutic use; D016049:Didanosine / Q000191:economics / Q000592:standards / Q000627:therapeutic use; D024882:Drug Resistance, Viral; D000068679:Emtricitabine; D006678:HIV / Q000187:drug effects; D015658:HIV Infections / Q000188:drug therapy*; D006801:Humans; D019259:Lamivudine / Q000191:economics / Q000592:standards / Q000627:therapeutic use; D010078:Oxazines / Q000191:economics / Q000592:standards / Q000627:therapeutic use; D011788:Quality of Life; D018894:Reverse Transcriptase Inhibitors / Q000191:economics / Q000592:standards / Q000627:therapeutic use*
D000480:Alkynes; D019380:Anti-HIV Agents; D048588:Benzoxazines; D003521:Cyclopropanes; D010078:Oxazines; D018894:Reverse Transcriptase Inhibitors; D003841:Deoxycytidine; D019259:Lamivudine; D000068679:Emtricitabine; C098320:efavirenz; D016049:Didanosine