title: [Immunological indices in gastric cancer].
abstract: Immunological indices were assayed in 167 patients with gastric cancer. Tumor growth involved reduction in levels of neutrophil peroxide (p<0.05), CD3+ and CD19+-cells (p<0.05) as well as intensification of apoptosis of lymphocytes (p<0.05). As monocytic and granulocytic phagocytosis (p<0.001) and HLA-DR-expression in monocytes (p<0.001) diminished, and mitogen-induced proliferative activity of mononuclear cells suppressed (p<0.05), total and relative levels of CD8+-cells (p<0.05) and spontaneous proliferative activity of mononuclear cells (p<0.05) in peripheral blood increased. Such changes should not be reganded as expression of immunosuppression alone. Mechanisms of immunological failure inherent in tumor growth need to be investigated further.
authors.forename: I G
authors.initials: IG
authors.lastname: Solov'eva
authors.forename: D N
authors.initials: DN
authors.lastname: Egorov
authors.forename: K V
authors.initials: KV
authors.lastname: Bardosanidze
authors.forename: E R
authors.initials: ER
authors.lastname: Chernykh
authors.forename: O Iu
authors.initials: OIu
authors.lastname: Leplina
authors.forename: V S
authors.initials: VS
authors.lastname: Kozhevnikov
authors.forename: V V
authors.initials: VV
authors.lastname: Abramov
authors.forename: V A
authors.initials: VA
authors.lastname: Kozlov
mesh_terms: D000328:Adult; D000368:Aged; D017209:Apoptosis; D005260:Female; D006684:HLA-DR Antigens / Q000276:immunology; D006801:Humans; D016130:Immunophenotyping; D008297:Male; D008875:Middle Aged; D010587:Phagocytosis; D013274:Stomach Neoplasms / Q000276:immunology*
chemical_list: D006684:HLA-DR Antigens