Sulfatide and its synthetic analogues recognition by Moraxella catarrhalis.
Moraxella catarrhalis is one of the major pathogens of respiratory and middle ear infections. Attachment of this bacterium to the surface of human pharyngeal epithelial cells is the first step in the pathogenesis of infections. This study revealed that sulfatide might act as a binding molecule for the attachment of M. catarrhalis to human pharyngeal epithelial cells. Furthermore, six different synthetic sulfatides were found to inhibit the attachment of M. catarrhalis significantly at an optimum concentration of 10 microg/ml. Synthetic sulfatides may have the potential to be used as a therapy to prevent M. catarrhalis infections.
Ozcelik
Pinar
P
Department of Molecular Biology and Genetics, Bilkent University, Ankara, Turkey.
Bezirci
Fatma Betul
FB
Suzuki
Yasuo
Y
Uzawa
Hirotaka
H
Nishida
Yoshihiro
Y
Kobayashi
Kazukiyo
K
Suzuki
Takashi
T
Miyamoto
Daisei
D
Nagatake
Tsuyoshi
T
Ahmed
Kamruddin
K
D018829:Adhesins, Bacterial; D001422:Bacterial Adhesion / Q000187:drug effects / Q000502:physiology*; D004847:Epithelial Cells / Q000382:microbiology; D006801:Humans; D001936:Moraxella catarrhalis / Q000187:drug effects* / Q000472:pathogenicity; D045828:Moraxellaceae Infections; D010614:Pharynx / Q000166:cytology / Q000382:microbiology*; D013433:Sulfoglycosphingolipids / Q000494:pharmacology*
D018829:Adhesins, Bacterial; D013433:Sulfoglycosphingolipids