Structural properties of proteins specific to the myelin sheath.
The myelin sheath is an insulating membrane layer surrounding myelinated axons in vertebrates, which is formed when the plasma membrane of an oligodendrocyte or a Schwann cell wraps itself around the axon. A large fraction of the total protein in this membrane layer is comprised of only a small number of individual proteins, which have certain intriguing structural properties. The myelin proteins are implicated in a number of neurological diseases, including, for example, autoimmune diseases and peripheral neuropathies. In this review, the structural properties of a number of myelin-specific proteins are described.
Kursula
P
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Department of Biochemistry, University of Oulu, Oulu, Finland. petri.kursula@oulu.fi
D063309:2',3'-Cyclic Nucleotide 3'-Phosphodiesterase; D000595:Amino Acid Sequence; D000818:Animals; D006801:Humans; D007136:Immunoglobulins / Q000737:chemistry; D008565:Membrane Proteins / Q000737:chemistry; D008958:Models, Molecular; D008969:Molecular Sequence Data; D004676:Myelin Basic Protein / Q000737:chemistry; D018993:Myelin P0 Protein / Q000737:chemistry; D009185:Myelin Proteins / Q000737:chemistry*; D009186:Myelin Sheath / Q000737:chemistry* / Q000648:ultrastructure; D018992:Myelin-Associated Glycoprotein / Q000737:chemistry; D063308:Myelin-Oligodendrocyte Glycoprotein; D010727:Phosphoric Diester Hydrolases / Q000737:chemistry; D017434:Protein Structure, Tertiary; D016415:Sequence Alignment; D033921:Vesicular Transport Proteins / Q000737:chemistry; D015032:Zinc / Q000032:analysis
D007136:Immunoglobulins; C571326:MOG protein, human; C501262:MYRIP protein, human; D008565:Membrane Proteins; D004676:Myelin Basic Protein; D018993:Myelin P0 Protein; D009185:Myelin Proteins; D018992:Myelin-Associated Glycoprotein; D063308:Myelin-Oligodendrocyte Glycoprotein; D033921:Vesicular Transport Proteins; C086745:periaxin; D010727:Phosphoric Diester Hydrolases; D063309:2',3'-Cyclic Nucleotide 3'-Phosphodiesterase; C571337:CNP protein, human; D015032:Zinc