title: Acrodermatitis enteropathica and an overview of zinc metabolism.
abstract: Acrodermatitis enteropathica is a rare autosomal recessive disorder of zinc deficiency. The genetic defect has been mapped to 8q24 and the defective gene identified as SLC39A4, which encodes the zinc transporter Zip4. The diagnosis is made by way of clinical presentation together with histopathology and laboratory tests. Here we provide an overview of zinc metabolism and a description of inherited and acquired zinc deficiency.
authors.affiliation: Department of Dermatology, University of California-Davis, Sacramento, CA 95816, USA.
authors.forename: Emanual
authors.initials: E
authors.lastname: Maverakis
authors.forename: Maxwell A
authors.initials: MA
authors.lastname: Fung
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Lynch
authors.forename: Michelle
authors.initials: M
authors.lastname: Draznin
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Michael
authors.forename: Beth
authors.initials: B
authors.lastname: Ruben
authors.forename: Nasim
authors.initials: N
authors.lastname: Fazel
mesh_terms: D000169:Acrodermatitis / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics* / Q000378:metabolism; D000328:Adult; D000818:Animals; D027682:Cation Transport Proteins / Q000737:chemistry / Q000172:deficiency* / Q000235:genetics / Q000502:physiology; D004032:Diet; D004195:Disease Models, Animal; D005260:Female; D005786:Gene Expression Regulation; D005808:Genes, Recessive; D006801:Humans; D007223:Infant; D007408:Intestinal Absorption; D007413:Intestinal Mucosa / Q000378:metabolism; D007583:Jejunum / Q000378:metabolism; D008286:Malabsorption Syndromes / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics* / Q000378:metabolism; D008297:Male; D051379:Mice; D008817:Mice, Mutant Strains; D008892:Milk / Q000737:chemistry; D009751:Nutritional Requirements; D012867:Skin / Q000473:pathology; D015032:Zinc / Q000172:deficiency* / Q000378:metabolism / Q000493:pharmacokinetics / Q000502:physiology / Q000627:therapeutic use
chemical_list: D027682:Cation Transport Proteins; C486791:SLC39A4 protein, human; D015032:Zinc