title: [Cryotherapy is useful and safe in the prevention of oral mucositis after high-dose melphalan (L-PAM)].
abstract: We prospectively assessed the effectiveness of cryotherapy after high-dose L-PAM to prevent oral mucositis. Cryotherapy with ice tips was commenced 15 minutes before L-PAM administration, and continued until the end of administration. Twenty-six patients were enrolled in this study. Thirteen patients with myeloma were treated with 200 mg/m2 L-PAM followed by autologous peripheral blood stem cell transplantation, and 13 patients (4 AML, 4 MDS, 2 ALL, 2 lymphoma and 1 CML) were treated with 140 mg/m2 L-PAM followed by allogeneic stem cell transplantation. Grade 1 mucositis occurred in four of 13 patients (31%) with 200 mg/m2 L-PAM, and 2 of 13 patients (16%) with 140 mg/m2 L-PAM. Only one patient had grade 2 mucositis, and no grade 3 mucositis were observed. The procedure was well tolerated in all patients. These data suggest that cryotherapy is effective to minimize L-PAM-induced oral mucositis.
authors.affiliation: Department of Nursing, Kagawa University Hospital.
authors.forename: Noriko
authors.initials: N
authors.lastname: Inagaki
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Ohue
authors.forename: Hiroe
authors.initials: H
authors.lastname: Shigeta
authors.forename: Taizo
authors.initials: T
authors.lastname: Tasaka
mesh_terms: D000328:Adult; D000368:Aged; D018906:Antineoplastic Agents, Alkylating / Q000009:adverse effects*; D017679:Cryotherapy; D005260:Female; D006801:Humans; D007938:Leukemia / Q000628:therapy; D008223:Lymphoma / Q000628:therapy; D008297:Male; D008558:Melphalan / Q000009:adverse effects*; D008875:Middle Aged; D033581:Stem Cell Transplantation; D013280:Stomatitis / Q000139:chemically induced / Q000517:prevention & control*
chemical_list: D018906:Antineoplastic Agents, Alkylating; D008558:Melphalan