Distribution of 1298A>C polymorphism of methylenetetrahydrofolate reductase gene in patients with bipolar disorder and schizophrenia.
We investigated the genotype frequency of methylenetetrahydrofolate reductase (MTHFR) 1298A>C polymorphism in the group of patients with bipolar disorder type I (BDI) (n=200) and schizophrenia (n=200) and in the control group (n=300). Odds ratio (OR) for patients with BD and schizophrenia in 1298CC homozygous state was 3.768 (95% CI=1.752-8.104); P=0.0003; (P=0.0006 after Bonferroni correction) and 2.694; (95% CI=1.207-6.013); P=0.0123 (P=0.0246 after Bonferroni correction), respectively. The stratification of patients based on gender revealed significant association of 1298CC genotype with female patients only with BDI (OR=7.293; 95% CI=2.017-26.363; P=0.0005). Our results confirm association of BD and schizophrenia with the 1p36.3 MTHFR locus and with the methyl group transfer using folate-dependent one-carbon pathway.
Kempisty
Bartosz
B
Department of Biochemistry and Molecular Biology, University of Medical Sciences, 6 Swiecickiego St., 60-781 Poznan, Poland.
Bober
Anna
A
Łuczak
Marta
M
Czerski
Piotr
P
Szczepankiewicz
Aleksandra
A
Hauser
Joanna
J
Jagodziński
Paweł P
PP
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001714:Bipolar Disorder / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D008875:Middle Aged; D016017:Odds Ratio; D011044:Poland / Q000453:epidemiology; D011110:Polymorphism, Genetic / Q000235:genetics / Q000502:physiology*; D012307:Risk Factors; D012559:Schizophrenia / Q000453:epidemiology / Q000235:genetics*; D012737:Sex Factors
D042965:Methylenetetrahydrofolate Reductase (NADPH2)