title: Mechanism of neuronal injury in cerebral venous thrombosis.
abstract: The impact of CVT on the brain is wide spectrum, ranging from completely normal parenchyma to brain oedema and/or haemorrhage. Multiple factors relate to neuronal injury in CVT including; dural sinus pressure, increased venous flow velocities, collateralization of venous channels, rate of occlusion, development of cytotoxic and vasogenic oedema, recanalization and accelerated myelination. It is suggested that recanalization of occluded vein, as well as, the presence or absence and the efficiency of intracranial venous collaterals, may have an impact on the extent of brain tissue damage and hence the prognosis of acute CVT.
authors.affiliation: Department of Neurology, The Aga Khan University, Karachi.
authors.forename: Uzma
authors.initials: U
authors.lastname: Usman
authors.forename: Mohammad
authors.initials: M
authors.lastname: Wasay
mesh_terms: D002545:Brain Ischemia / Q000209:etiology* / Q000503:physiopathology; D002543:Cerebral Hemorrhage / Q000209:etiology* / Q000503:physiopathology; D002550:Cerebral Veins / Q000473:pathology*; D003711:Demyelinating Diseases / Q000209:etiology*; D006801:Humans; D020767:Intracranial Thrombosis / Q000150:complications* / Q000188:drug therapy; D009474:Neurons; D011379:Prognosis; D012307:Risk Factors; D012851:Sinus Thrombosis, Intracranial / Q000150:complications* / Q000188:drug therapy; D020246:Venous Thrombosis / Q000150:complications* / Q000188:drug therapy