[Immunological indices in gastric cancer].
Immunological indices were assayed in 167 patients with gastric cancer. Tumor growth involved reduction in levels of neutrophil peroxide (p<0.05), CD3+ and CD19+-cells (p<0.05) as well as intensification of apoptosis of lymphocytes (p<0.05). As monocytic and granulocytic phagocytosis (p<0.001) and HLA-DR-expression in monocytes (p<0.001) diminished, and mitogen-induced proliferative activity of mononuclear cells suppressed (p<0.05), total and relative levels of CD8+-cells (p<0.05) and spontaneous proliferative activity of mononuclear cells (p<0.05) in peripheral blood increased. Such changes should not be reganded as expression of immunosuppression alone. Mechanisms of immunological failure inherent in tumor growth need to be investigated further.
Solov'eva
I G
IG
Egorov
D N
DN
Bardosanidze
K V
KV
Chernykh
E R
ER
Leplina
O Iu
OIu
Kozhevnikov
V S
VS
Abramov
V V
VV
Kozlov
V A
VA
D000328:Adult; D000368:Aged; D017209:Apoptosis; D005260:Female; D006684:HLA-DR Antigens / Q000276:immunology; D006801:Humans; D016130:Immunophenotyping; D008297:Male; D008875:Middle Aged; D010587:Phagocytosis; D013274:Stomach Neoplasms / Q000276:immunology*
D006684:HLA-DR Antigens