Five new steroidal compounds from Ypsilandra thibetica.
Five new steroids, including the four new steroidal saponins ypsilandroside B (1), ypsilandroside A (2), isoypsilandroside A (4), and isoypsilandroside B (5), as well as the new steroidal sapogenin isoypsilandrogenin (3), were isolated from the whole plant of Ypsilandra thibetica Franch. Their structures were determined on the basis of spectroscopic analyses, including extensive 2D-NMR techniques. The structure and relative configuration of ypsilandroside B (=(3beta,12alpha,25R)-3-[(alpha-L-rhamnopyranosyl-(1-->2)-beta-D-apiofuranosyl)oxy]spirost-5-ene-12,27-diol; 1) was unequivocally determined by single-crystal X-ray diffraction. The antifungal and antibacterial activities of 1-5 towards various types of fungi and bacteria are reported.
Xie
Bai-Bo
BB
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, P.R. China.
Liu
Hai-Yang
HY
Ni
Wei
W
Chen
Chang-Xiang
CX
Lü
Yang
Y
Wu
Li
L
Zheng
Qi-Tai
QT
D000900:Anti-Bacterial Agents / Q000737:chemistry; D000935:Antifungal Agents / Q000737:chemistry; D002626:Chemistry, Pharmaceutical / Q000379:methods; D000431:Ethanol / Q000737:chemistry; D005663:Furans / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D019684:Magnoliopsida / Q000378:metabolism*; D008956:Models, Chemical; D008958:Models, Molecular; D010936:Plant Extracts / Q000737:chemistry*; D010946:Plants, Medicinal / Q000378:metabolism; D012502:Sapogenins / Q000737:chemistry; D012503:Saponins / Q000737:chemistry* / Q000302:isolation & purification*; D013256:Steroids / Q000737:chemistry*; D014961:X-Ray Diffraction
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D005663:Furans; D010936:Plant Extracts; D012502:Sapogenins; D012503:Saponins; D013256:Steroids; D000431:Ethanol