Novel therapeutic strategies via the apoptosis pathways to resolve chronic eosinophilic inflammation.
Physiologic cell death is a necessary process to maintain correct cell numbers. Alterations in this process may contribute to the pathogenesis of a number of human diseases. During the past few years, evidence has been adduced indicating that eosinophilic disorders are associated with a defect in eosinophil apoptosis. Here we review our recent progress in understanding the processes regulating eosinophil apoptosis, and the implications of these results for novel therapeutic possibilities.
Simon
H U
HU
Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Obere Strasse 22, CH-7270 Davos, Switzerland.