title: Argentine population genetic structure: large variance in Amerindian contribution.
abstract: Argentine population genetic structure was examined using a set of 78 ancestry informative markers (AIMs) to assess the contributions of European, Amerindian, and African ancestry in 94 individuals members of this population. Using the Bayesian clustering algorithm STRUCTURE, the mean European contribution was 78%, the Amerindian contribution was 19.4%, and the African contribution was 2.5%. Similar results were found using weighted least mean square method: European, 80.2%; Amerindian, 18.1%; and African, 1.7%. Consistent with previous studies the current results showed very few individuals (four of 94) with greater than 10% African admixture. Notably, when individual admixture was examined, the Amerindian and European admixture showed a very large variance and individual Amerindian contribution ranged from 1.5 to 84.5% in the 94 individual Argentine subjects. These results indicate that admixture must be considered when clinical epidemiology or case control genetic analyses are studied in this population. Moreover, the current study provides a set of informative SNPs that can be used to ascertain or control for this potentially hidden stratification. In addition, the large variance in admixture proportions in individual Argentine subjects shown by this study suggests that this population is appropriate for future admixture mapping studies.
authors.affiliation: Rowe Program in Human Genetics, Department of Biological Chemistry, University of California Davis, Davis, CA 95616, USA. mfseldin@ucdavis.edu
authors.forename: Michael F
authors.initials: MF
authors.lastname: Seldin
authors.forename: Chao
authors.initials: C
authors.lastname: Tian
authors.forename: Russell
authors.initials: R
authors.lastname: Shigeta
authors.forename: Hugo R
authors.initials: HR
authors.lastname: Scherbarth
authors.forename: Gabriel
authors.initials: G
authors.lastname: Silva
authors.forename: John W
authors.initials: JW
authors.lastname: Belmont
authors.forename: Rick
authors.initials: R
authors.lastname: Kittles
authors.forename: Susana
authors.initials: S
authors.lastname: Gamron
authors.forename: Alberto
authors.initials: A
authors.lastname: Allevi
authors.forename: Simon A
authors.initials: SA
authors.lastname: Palatnik
authors.forename: Alejandro
authors.initials: A
authors.lastname: Alvarellos
authors.forename: Sergio
authors.initials: S
authors.lastname: Paira
authors.forename: Cesar
authors.initials: C
authors.lastname: Caprarulo
authors.forename: Carolina
authors.initials: C
authors.lastname: Guillerón
authors.forename: Luis J
authors.initials: LJ
authors.lastname: Catoggio
authors.forename: Cristina
authors.initials: C
authors.lastname: Prigione
authors.forename: Guillermo A
authors.initials: GA
authors.lastname: Berbotto
authors.forename: Mercedes A
authors.initials: MA
authors.lastname: García
authors.forename: Carlos E
authors.initials: CE
authors.lastname: Perandones
authors.forename: Bernardo A
authors.initials: BA
authors.lastname: Pons-Estel
authors.forename: Marta E
authors.initials: ME
authors.lastname: Alarcon-Riquelme
mesh_terms: D044466:Asian People / Q000235:genetics; D001499:Bayes Theorem; D044383:Black People / Q000235:genetics; D005787:Gene Frequency; D005819:Genetic Markers; D014644:Genetic Variation; D005828:Genetics, Population; D006801:Humans; D007199:Indians, South American / Q000235:genetics*; D017058:Mexican Americans / Q000235:genetics; D044465:White People / Q000235:genetics
chemical_list: D005819:Genetic Markers