[A case of drug-induced pneumonitis due to amiodarone].
An 80-year-old man, who had been taking the antiarrhythmic drug amiodarone for chronic atrial fibrillation since October 2004, developed dyspnea and fever in June 2005, and was admitted to our hospital. Chest X-ray and CT scan showed ground-glass opacities in all lung fields. Arterial blood gas analysis revealed hypoxemia. These findings led to a diagnosis of acute respiratory distress syndrome. Oral amiodarone was discontinued, and steroid pulse therapy was started; however, the disease progressed rapidly, and the patient died on the fourth hospital day. Autopsy showed diffuse alveolar damage, accumulation of edema fluid in the alveolar spaces, and the presence of foamy macrophages, leading to a diagnosis of amiodarone-induced pulmonary damage.
Kobayashi
Kashin
K
Department of Respiratory Internal Medicine, Fujita Health University Second Educational Hospital.
Horiguchi
Takahiko
T
Kondo
Rieko
R
Shiga
Mamoru
M
Hirose
Masahiro
M
Itou
Tomohiro
T
Torigoe
Hiroshi
H
Hayashi
Nobuyuki
N
Ouhira
Daisuke
D
D000369:Aged, 80 and over; D000638:Amiodarone / Q000009:adverse effects*; D000889:Anti-Arrhythmia Agents / Q000009:adverse effects*; D001281:Atrial Fibrillation / Q000188:drug therapy; D002908:Chronic Disease; D006801:Humans; D008297:Male; D012128:Respiratory Distress Syndrome / Q000139:chemically induced* / Q000473:pathology
D000889:Anti-Arrhythmia Agents; D000638:Amiodarone