Changes in the lipid composition of blood plasma and liver in rats induced by severe psychic trauma.
The concentration of high-density lipoprotein cholesterol and triglycerides in rat serum sharply decreased after psychic trauma caused by life hazard. The content of these substances remained unchanged for not less than 1 week after trauma. The concentration of high-density lipoprotein cholesterol was low, while serum content of triglycerides increased 6 weeks after trauma. The concentration of high-density lipoprotein cholesterol significantly decreased after repeated psychic trauma. These changes were accompanied by a sharp increase in the concentration of triglycerides in the serum. Total cholesterol concentration in the liver decreased under these conditions.
Tsikunov
S G
SG
I. P. Pavlov Department of Physiology, Institute of Experimental Medicine, Russian Academy of Medical Sciences, St. Petersburg. klim@iemcng.spb.su
Klyueva
N N
NN
Kusov
A G
AG
Vinogradova
T V
TV
Klimenko
V M
VM
Denisenko
A D
AD
D000818:Animals; D001522:Behavior, Animal / Q000502:physiology*; D004195:Disease Models, Animal; D008075:Lipoproteins, HDL / Q000097:blood*; D008099:Liver / Q000378:metabolism*; D008297:Male; D009068:Movement / Q000502:physiology*; D051381:Rats; D013313:Stress Disorders, Post-Traumatic / Q000097:blood* / Q000378:metabolism* / Q000523:psychology; D014280:Triglycerides / Q000097:blood*
D008075:Lipoproteins, HDL; D014280:Triglycerides