title: Non-fluent progressive aphasia: cerebral metabolic patterns and brain reserve.
abstract: Functional imaging studies suggest that brain reserve allows patients with Alzheimer's disease with more years of schooling to cope better with brain damage. No studies exist on patients with non-fluent progressive aphasia (NFPA). We aimed to explore metabolic patterns of patients with NFPA and to provide evidence for brain reserve in NFPA. 11 right-handed patients with NFPA and 16 age-matched controls underwent (18)F-FDG PET imaging. Scans of patients and controls were compared in SPM2. A linear regression analysis with glucose metabolism as dependent variable and years of schooling as the independent variable, adjusted for age, gender, and a total score of the CERAD neuropsychological battery was conducted. The NFPA group showed a hypometabolism of the left hemisphere including the middle frontal, and inferior temporal and angular gyri, and the bilateral caudate nuclei and thalami (p(corr)<0.05). The regression analysis revealed a significant inverse association between education and glucose metabolism in the left inferior temporal, parahippocampal, and supramarginal gyri (p(corr)<0.05). We conclude that brain reserve is also present in NFPA.
authors.affiliation: Departments of Psychiatry and Psychotherapy, Technische Universität München, Germany.
authors.forename: Robert
authors.initials: R
authors.lastname: Perneczky
authors.forename: Janine
authors.initials: J
authors.lastname: Diehl-Schmid
authors.forename: Corina
authors.initials: C
authors.lastname: Pohl
authors.forename: Alexander
authors.initials: A
authors.lastname: Drzezga
authors.forename: Alexander
authors.initials: A
authors.lastname: Kurz
mesh_terms: D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D018888:Aphasia, Primary Progressive / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000503:physiopathology; D001921:Brain / Q000033:anatomy & histology / Q000000981:diagnostic imaging / Q000378:metabolism*; D001931:Brain Mapping; D003072:Cognition Disorders / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000503:physiopathology; D004522:Educational Status; D004734:Energy Metabolism / Q000502:physiology*; D005260:Female; D019788:Fluorodeoxyglucose F18; D005625:Frontal Lobe / Q000000981:diagnostic imaging / Q000378:metabolism / Q000503:physiopathology; D007839:Functional Laterality / Q000502:physiology; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography; D011237:Predictive Value of Tests; D017678:Sex Distribution; D013702:Temporal Lobe / Q000000981:diagnostic imaging / Q000378:metabolism / Q000503:physiopathology
chemical_list: D019788:Fluorodeoxyglucose F18; D005947:Glucose