Differential expression of decorin in localized scleroderma following ultraviolet-A1 irradiation.
Patients with localized scleroderma underwent an 8-week course of ultraviolet A1 phototherapy. At baseline, decorin levels of lesional skin were significantly lower than those of nonlesional skin and healthy control subjects. After ultraviolet A1 phototherapy, decorin levels of lesional skin were significantly higher than baseline. Decorin may be of significance in the pathogenesis of localized scleroderma.
Gambichler
Thilo
T
Department of Dermatology, Ruhr-University Bochum, Bochum, Germany. t.gambichler@klinikum-bochum.de
Skrygan
Marina
M
Tomi
Nordwig S
NS
Altmeyer
Peter
P
Kreuter
Alexander
A
D000328:Adult; D058575:Decorin; D016326:Extracellular Matrix Proteins / Q000378:metabolism*; D005260:Female; D006801:Humans; D008875:Middle Aged; D010789:Phototherapy; D011509:Proteoglycans / Q000378:metabolism*; D045745:Scleroderma, Limited / Q000378:metabolism* / Q000628:therapy; D012867:Skin / Q000378:metabolism*
C546878:DCN protein, human; D058575:Decorin; D016326:Extracellular Matrix Proteins; D011509:Proteoglycans