Microchip technology for automated and parallel patch-clamp recording.
The patch-clamp technique is the state-of-the-art technology for the study of a large class of membrane proteins called ion channels. Ion channels mediate electrical current flow, have crucial roles in cellular physiology, and are important drug targets. However, patch clamping is a laborious process requiring a skilled experimenter and is, therefore, not compatible with the high throughput needed in drug development. The solution for automated and parallel patch-clamp measurements that is provided by microchip technology is presented here.
Brüggemann
Andrea
A
Nanion Technologies GmbH, Pettenkoferstr. 12, 80336 München, Germany.
Stoelzle
Sonja
S
George
Michael
M
Behrends
Jan C
JC
Fertig
Niels
N
D000818:Animals; D006801:Humans; D007473:Ion Channels / Q000502:physiology; D056656:Lab-On-A-Chip Devices; D018408:Patch-Clamp Techniques / Q000295:instrumentation*
D007473:Ion Channels