TIS11D is a candidate pro-apoptotic p53 target gene.
A number of target genes for the tumor suppressor, p53, have been identified, however, the mechanisms that contribute to p53-dependent apoptosis remain to be fully elucidated. In a comprehensive screen for p53 target genes by differential display, we have identified TIS11D as a p53-inducible gene. Induction of TIS11D mRNA was confirmed by Northern Blot in response to p53 expression. Inducible expression of TIS11D resulted in inhibition of cell proliferation and apoptosis. These data suggest TIS11D as a candidate p53 target gene that may be part of the network of genes responsible for p53-dependent apoptosis.
Jackson
Roger S
RS
Vanderbilt-Ingram Comprehensive Cancer Center, Department of Cancer Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232-6840, USA.
Cho
Yong-Jig
YJ
Liang
Peng
P
D000818:Animals; D017209:Apoptosis; D019556:COS Cells; D016923:Cell Death; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D002522:Chlorocebus aethiops; D020869:Gene Expression Profiling; D006801:Humans; D021381:Protein Transport; D011993:Recombinant Fusion Proteins / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*; D051816:Tristetraprolin / Q000235:genetics / Q000378:metabolism*; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*
D011993:Recombinant Fusion Proteins; D014157:Transcription Factors; D051816:Tristetraprolin; D016159:Tumor Suppressor Protein p53; C091750:ZFP36L2 protein, human