Interstitial cystitis pathogenesis and treatment.
OBJECTIVE
Interstitial cystitis remains an idiopathic illness characterized by urinary frequency, urgency and pelvic pain with substantial morbidity in those affected. There is significant variability in the presentation, severity of symptoms and response to therapy. This review focuses on recent findings on the possible pathogenesis and potential treatments for this disease.


RESULTS
Interstitial cystitis is manifested by sensory hypersensitivity. A small volume of urine will be associated with an exaggerated sensation of pain or pressure and urinary urgency. There is continued research regarding how this process is initiated and maintained and to what extent systemic dysfunction of the immune or autonomic nervous system may play a role. The urothelial lining has been demonstrated to be capable of secreting a large number of potential signaling molecules that may be significant factors in the disease.


CONCLUSIONS
The pathogenesis of interstitial cystitis remains uncertain and the illness has significant diversity. Additional research is needed to establish subtypes that share common processes that can be targeted for treatment as a single effective therapy for the condition remains elusive.
Mayer
Robert
R
Department of Urology, University of Rochester Medical Center, Rochester, New York 14642, USA. robert_mayer@urmc.rochester.edu
D018856:Cystitis, Interstitial / Q000453:epidemiology / Q000503:physiopathology* / Q000628:therapy*; D006801:Humans; D017699:Pelvic Pain / Q000188:drug therapy / Q000209:etiology*