A novel t(2;3)(p11;q27) in a case of follicular lymphoma.
Rearrangement of the BCL6 gene is found in follicular lymphomas and in diffuse large B cell lymphomas of follicular center cell origin. The breakpoints cluster mainly in a region spanning the first noncoding exon of the gene (the major breakpoint region). A second breakpoint cluster has also been identified upstream of the first BCL6 noncoding exon (the alternative breakpoint region [ABR]). To date, eight different rearrangements involving the ABR have been reported. Here, we describe a novel rearrangement involving a t(2;3)(p11;q27) translocation that affects the ABR in an unusual combination with the IGK locus.
Tapinassi
Cinzia
C
IFOM, FIRC Institute for Molecular Oncology Foundation, Via Adamello 16, 20139 Milan, Italy.
Micucci
Carla
C
Lahortiga
Idoya
I
Malazzi
Omar
O
Gasparini
Patrizia
P
Gorosquieta
Ana
A
Odero
Maria D
MD
Belloni
Elena
E
D000368:Aged; D002889:Chromosomes, Human, Pair 2 / Q000235:genetics*; D002893:Chromosomes, Human, Pair 3 / Q000235:genetics*; D015321:Gene Rearrangement; D006801:Humans; D007136:Immunoglobulins / Q000235:genetics; D008224:Lymphoma, Follicular / Q000145:classification / Q000235:genetics*; D008297:Male; D016133:Polymerase Chain Reaction; D051560:Proto-Oncogene Proteins c-bcl-6 / Q000235:genetics; D014178:Translocation, Genetic / Q000235:genetics*
C014609:IgK; D007136:Immunoglobulins; D051560:Proto-Oncogene Proteins c-bcl-6