GABAergic malfunction in the limbic system resulting from an aboriginal genetic defect in voltage-gated Na+-channel SCN5A is proposed to give rise to susceptibility to schizophrenia.
Roberts
Eugene
E
Department of Neurobiochemistry, Beckman Research Institute, City of Hope Medical Center, Duarte, California 91010, USA.
D017353:Gene Deletion; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D008032:Limbic System / Q000378:metabolism* / Q000473:pathology; D008962:Models, Theoretical; D009124:Muscle Proteins / Q000172:deficiency / Q000235:genetics*; D062554:NAV1.5 Voltage-Gated Sodium Channel; D009474:Neurons / Q000187:drug effects / Q000378:metabolism; D012559:Schizophrenia / Q000188:drug therapy / Q000235:genetics* / Q000503:physiopathology; D015222:Sodium Channels / Q000172:deficiency / Q000235:genetics*; D016896:Treatment Outcome; D005680:gamma-Aminobutyric Acid / Q000172:deficiency / Q000378:metabolism*
D009124:Muscle Proteins; D062554:NAV1.5 Voltage-Gated Sodium Channel; C568320:SCN5A protein, human; D015222:Sodium Channels; D005680:gamma-Aminobutyric Acid