The effects of intravaginal clindamycin and metronidazole therapy on vaginal mobiluncus morphotypes in patients with bacterial vaginosis.
OBJECTIVE
The objective of this study was to compare the effects of treatments for bacterial vaginosis (BV) on vaginal Mobiluncus morphotypes.


METHODS
Analyses were performed on Mobiluncus scores from similarly conducted studies evaluating clindamycin vaginal single-dose cream (CVSDC) or metronidazole vaginal gel (MVG) in 55 patients with BV and with Mobiluncus morphotypes at baseline.


RESULTS
Both treatment groups demonstrated significant reductions in Mobiluncus score. However, the Mobiluncus score at test-of-cure was lower in the CVSDC than in the MVG group (P=0.0471). More patients in the CVSDC group than in the MVG group achieved microbiologic (57.5% vs. 26.7%; P=0.04), clinical (57.5% vs. 26.7%; P=0.04), and therapeutic cures of BV (45.0% vs. 20.0%; P=0.09).


CONCLUSIONS
Clindamycin reduces vaginal Mobiluncus morphotypes to a greater extent than metronidazole in patients with BV; this correlates with a higher BV cure rate.
Nyirjesy
Paul
P
Department of Obstetrics and Gynecology, Drexel University College of Medicine, Philadelphia, PA 19102, USA. pnyirjes@drexelmed.edu
McIntosh
Matthew J
MJ
Steinmetz
Jana I
JI
Schumacher
Robert J
RJ
Joffrion
James L
JL
D000193:Actinomycetales Infections / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology; D000282:Administration, Intravaginal; D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000494:pharmacology; D002981:Clindamycin / Q000008:administration & dosage* / Q000494:pharmacology; D005260:Female; D006801:Humans; D008795:Metronidazole / Q000008:administration & dosage* / Q000494:pharmacology; D017904:Mobiluncus / Q000145:classification / Q000187:drug effects*; D012189:Retrospective Studies; D012648:Self Care; D016896:Treatment Outcome; D016585:Vaginosis, Bacterial / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology
D000900:Anti-Bacterial Agents; D008795:Metronidazole; D002981:Clindamycin