Protective effect of human heat shock protein 60 suggested by its association with decreased seropositivity to pathogens.
The presence of heat shock protein 60 (Hsp60) in human plasma has been linked with cardiovascular disease (CVD). In this study, the examination of the relationship between Hsp60 in plasma and seropositivity for three microbial agents, which are thought to be risk factors for CVD, surprisingly revealed a negative association between Hsp60 and seropositivity, suggesting a protective effect of this circulating stress protein.
Steptoe
A
A
Department of Epidemiology and Public Health, UCL Eastman Dental Institute, University College London, London, United Kingdom.
Shamaei-Tousi
A
A
Gylfe
A
A
Bailey
L
L
Bergström
S
S
Coates
A R
AR
Henderson
B
B
D000368:Aged; D000906:Antibodies / Q000097:blood*; D018834:Chaperonin 60 / Q000502:physiology*; D002689:Chlamydia / Q000276:immunology*; D003587:Cytomegalovirus / Q000276:immunology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018139:Simplexvirus / Q000276:immunology*
D000906:Antibodies; D018834:Chaperonin 60