title: Use of bisphosphonates for resistant hypercalcemia in children with acute lymphoblastic leukemia: report of two cases and review of the literature.
abstract: Hypercalcemia is a rare complication of malignancy in children. We present two children, one of whom is the youngest reported, with CALLA+ B-cell acute lymphoblastic leukemia (ALL) who developed hypercalcemia at the time of diagnosis and were treated with relatively low-dose (0.5 mg/kg) intravenous pamidronate successive to conventional therapy. No major side effects were encountered except transient hypocalcemia and hypophosphatemia, which were easily managed by replacement therapy. Bisphosphonate therapy was found to be beneficial for the treatment of resistant hypercalcemia associated with ALL, even at relatively low doses.
authors.affiliation: Division of Endocrinology, Hacettepe University Faculty of Medicine, Ankara, Turkey.
authors.forename: Nesibe
authors.initials: N
authors.lastname: Andiran
authors.forename: Ayfer
authors.initials: A
authors.lastname: Alikaşifoğlu
authors.forename: Serhan
authors.initials: S
authors.lastname: Küpeli
authors.forename: Sevgi
authors.initials: S
authors.lastname: Yetgin
mesh_terms: D002648:Child; D004164:Diphosphonates / Q000627:therapeutic use*; D006801:Humans; D006934:Hypercalcemia / Q000188:drug therapy* / Q000209:etiology*; D007223:Infant; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications*
chemical_list: D004164:Diphosphonates