SNIP1: Myc's new helper in transcriptional activation.
c-Myc regulates target genes by engaging a number of transcriptional cofactors. In a recent issue of Molecular Cell, Fujii et al. (2006) showed that the FHA-domain protein SNIP1 is an important c-Myc coactivator that regulates c-Myc stability and is overexpressed in many tumors.
Larsson
Lars-Gunnar
LG
Department of Plant Biology and Forest Genetics, Swedish University of Agricultural Sciences, S-750 07 Uppsala, Sweden.
D002453:Cell Cycle; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics* / Q000378:metabolism; D008954:Models, Biological; D009369:Neoplasms / Q000378:metabolism*; D011401:Promoter Regions, Genetic; D016271:Proto-Oncogene Proteins c-myc / Q000235:genetics / Q000378:metabolism*; D016601:RNA-Binding Proteins; D015398:Signal Transduction; D015533:Transcriptional Activation
D047908:Intracellular Signaling Peptides and Proteins; D016271:Proto-Oncogene Proteins c-myc; D016601:RNA-Binding Proteins; C411545:SNIP1 protein, human