Suitability of the cingulate cortex for neural control.
Recent neuroprosthetic work has focused on the motor cortex as a source of voluntary control signals. However, the motor cortex can be damaged in upper motor neuron degenerative diseases such as primary lateral sclerosis and amyotrophic lateral sclerosis. The possibility exists that prefrontal areas may also be used in neuroprosthetic devices. Here, we report the use of the cingulate cortex in a neuroprosthetic model. Seven rats were able to significantly modulate spiking activity in the cingulate cortex in order to receive reward. Furthermore, experiments with single neurons provide evidence that the cingulate cortex neuronal modulation is highly flexible and thus useful for a neuroprosthetic device.
Marzullo
Timothy C
TC
Neuroscience Program, University of Michigan, Ann Arbor, MI 48109, USA. tmarzull@umich.edu
Miller
Charles R
CR
Kipke
Daryl R
DR
D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D001676:Biofeedback, Psychology / Q000502:physiology*; D002540:Cerebral Cortex / Q000502:physiology*; D004569:Electroencephalography / Q000379:methods*; D005071:Evoked Potentials / Q000502:physiology*; D006179:Gyrus Cinguli / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014836:Volition