title: Evaluation of the kinetic data for intramolecular 1,x-hydrogen shifts in alkyl radicals and structure/reactivity predictions from the carbocyclic model for the transition state.
abstract: Experimental and computational kinetic data for the intramolecular 1,x-hydrogen shift in alkyl radicals are compiled in Arrhenius format for x = 2-5. Significant experimental disparity remains, especially for x = 2 and 3. Experimental data for radicals with tert centers or bearing spectator substituents are lacking for all x, and none exist for x = 6. The common use of the strain energy of the unsubstituted (x+1)-carbocycle to coarsely model the activation energy for the 1,x-shift is extended to explore more subtle differences in progressively methyl-substituted systems by use of molecular mechanics estimates of differences in strain between radicals and carbocycles. For x = 5 and 6, a sterically driven increase in E is predicted for shifts in the tert --> tert class that apparently runs counter to the behavior of bimolecular hydrogen transfers. In contrast, a sterically driven decrease in E is predicted to result from spectator methyl groups for the prim --> prim reaction class for all x. There is no experimental basis to test these predictions; fragmentary computational evidence lends some support to the second but is ambiguous concerning the first. Possible deficiencies in the use of carbocycles as transition state models are discussed.
authors.affiliation: Chemical Sciences Division, Oak Ridge National Laboratory, PO Box 2008, Oak Ridge, Tennessee 37831-6197, USA. poutsmaml@ornl.gov
authors.forename: Marvin L
authors.initials: ML
authors.lastname: Poutsma
mesh_terms: D000478:Alkylation; D002244:Carbon / Q000737:chemistry; D003198:Computer Simulation; D003500:Cyclization; D005609:Free Radicals / Q000737:chemistry; D006859:Hydrogen / Q000737:chemistry*; D007700:Kinetics; D008956:Models, Chemical; D015394:Molecular Structure
chemical_list: D005609:Free Radicals; D002244:Carbon; D006859:Hydrogen