[Evaluation of the efficacy of harmful agents].
A method is proposed to determine the efficacy of harmful agents, which is based on the assessment of a response of experimental animals by the mathematical-statistical methods formalizing the approaches accepted in hygienic toxicology. It makes it possible to introduce a more detailed classification of their efficacy in accordance with the respective rather strict criteria. This method unifies this procedure to a great extent, thus lowering the influence of subjective factors, which lets us correctly solve the task of establishing the hygienic regulations. The results of evaluation of the efficacy of two combinations of the concentrations of copper, iron, chromium, and zinc contained in the drinking water are given as an example.
Katul'skiĭ
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D000818:Animals; D002857:Chromium / Q000032:analysis / Q000633:toxicity; D003300:Copper / Q000032:analysis / Q000633:toxicity; D004195:Disease Models, Animal; D004781:Environmental Exposure / Q000009:adverse effects; D018876:Environmental Illness / Q000139:chemically induced / Q000401:mortality; D007501:Iron / Q000032:analysis / Q000633:toxicity; D007928:Lethal Dose 50; D015233:Models, Statistical; D014116:Toxicology / Q000379:methods*; D014867:Water / Q000737:chemistry; D015032:Zinc / Q000032:analysis / Q000633:toxicity
D014867:Water; D002857:Chromium; D003300:Copper; D007501:Iron; D015032:Zinc