Corticotropin-releasing factor receptors and stress-related alterations of gut motor function.
Over the past few decades, corticotropin-releasing factor (CRF) signaling pathways have been shown to be the main coordinators of the endocrine, behavioral, and immune responses to stress. Emerging evidence also links the activation of CRF receptors type 1 and type 2 with stress-related alterations of gut motor function. Here, we review the role of CRF receptors in both the brain and the gut as part of key mechanisms through which various stressors impact propulsive activity of the gastrointestinal system. We also examine how these mechanisms translate into the development of new approaches for irritable bowel syndrome, a multifactorial disorder for which stress has been implicated in the pathophysiology.
Taché
Yvette
Y
CURE: Digestive Diseases Research Center, and Center for Neurovisceral Sciences & Women's Health, Department of Medicine, Division of Digestive Diseases, UCLA, Los Angeles, California 90073, USA. ytache@mednet.ucla.edu
Bonaz
Bruno
B
D001007:Anxiety / Q000503:physiopathology; D001921:Brain / Q000503:physiopathology; D041981:Gastrointestinal Tract / Q000503:physiopathology*; D006801:Humans; D008954:Models, Biological; D009043:Motor Activity / Q000502:physiology*; D009130:Muscle, Smooth / Q000503:physiopathology; D018019:Receptors, Corticotropin-Releasing Hormone / Q000502:physiology*; D015398:Signal Transduction; D013315:Stress, Psychological / Q000503:physiopathology*
D018019:Receptors, Corticotropin-Releasing Hormone