title: Cell/surface interactions and adhesion on bioactive glass 45S5.
abstract: This paper examines the effects of surface texture (smooth versus rough) on cell/surface interactions on the bioactive glass, 45S5. The cell surface interactions associated with cell spreading are studied using cell culture experiments. Subsequent energy dispersive x-ray spectroscopy is also used to reveal the distributions of calcium, phosphorous, sodium and oxygen on the surfaces of the bioactive glasses. The implications of the results are then discussed for the applications of textured bioactive glasses in medicine.
authors.affiliation: Princeton Institute of Science and Technology of Materials (PRISM) and The Department of Mechanical and Aerospace Engineering, Princeton University, Princeton, NJ 08544, USA.
authors.forename: S
authors.initials: S
authors.lastname: Levy
authors.forename: M
authors.initials: M
authors.lastname: Van Dalen
authors.forename: S
authors.initials: S
authors.lastname: Agonafer
authors.forename: W O
authors.initials: WO
authors.lastname: Soboyejo
mesh_terms: D016475:3T3 Cells; D000818:Animals; D001672:Biocompatible Materials; D002448:Cell Adhesion; D049109:Cell Proliferation; D002478:Cells, Cultured; D002516:Ceramics; D004577:Electron Probe Microanalysis / Q000379:methods; D005898:Glass; D051379:Mice; D018625:Microscopy, Atomic Force; D010006:Osteoblasts / Q000166:cytology* / Q000502:physiology* / Q000648:ultrastructure; D013499:Surface Properties; D013997:Time Factors
chemical_list: D001672:Biocompatible Materials; C425330:bioactive glass 45S5