The efficacy of adipokines and indices of metabolic syndrome as predictors of severe obesity-related hepatic steatosis.
The aim of this study was to investigate adiponectin, leptin, and metabolic syndrome as predictors of the severity of obesity-related steatosis. By ultrasonography steatosis-positive (cases) subjects (n = 141) were compared with controls (n = 111). Demographic and anthropometric data and serum concentrations of adiponectin, leptin, and insulin were measured. The impact of several criteria of metabolic syndrome, serum adiponectin concentrations, and serum leptin concentrations were tested using a multivariate logistic regression analysis. The frequency of metabolic syndrome was higher in cases (44.0% versus 9.2%; P < .0001). Cases were older and had higher insulin resistance, waist circumference, and lower concentrations of adiponectin (all P < .001). The upper adiponectin quartile was associated with a lesser grade of steatosis. Metabolic syndrome and adiponectin concentrations were independently associated with the probability of steatosis. In conclusion, adipokines and metabolic syndrome are useful indices for the prediction of the severity of obesity-related steatosis.
Méndez-Sánchez
Nahum
N
Liver Research Unit, Medica Sur Clinic and Foundation, Mexico City, Mexico, USA. nmendez@medicasur.org.mx
Chávez-Tapia
Norberto C
NC
Medina-Santillán
Roberto
R
Villa
Antonio R
AR
Sánchez-Lara
Karla
K
Ponciano-Rodríguez
Guadalupe
G
Ramos
Martha H
MH
Uribe
Misael
M
D052242:Adiponectin / Q000097:blood*; D000328:Adult; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005234:Fatty Liver / Q000097:blood* / Q000000981:diagnostic imaging / Q000209:etiology*; D005260:Female; D006801:Humans; D020738:Leptin / Q000097:blood*; D016015:Logistic Models; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000150:complications* / Q000000981:diagnostic imaging; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000150:complications* / Q000000981:diagnostic imaging; D012720:Severity of Illness Index; D014463:Ultrasonography
D052242:Adiponectin; D020738:Leptin