Molecular study of genes involved in virulence regulatory pathways in Bacillus anthracis vaccine strain "Carbosap".
This study investigated the genetic bases of attenuation in the Bacillus anthracis vaccine strain "Carbosap" used in Italy against anthrax in cattle and sheep. Twelve genes involved in virulence regulatory pathways underwent sequence analysis in comparison with a B. anthracis virulent strain.
La Rosa
Giuseppina
G
Istituto Superiore di Sanità, Environmental and Primary Prevention Department, Viale Regina Elena 299, 00161, Rome, Italy. giuseppina.larosa@iss.it
Muscillo
Michele
M
Sali
Michela
M
De Carolis
Elena
E
Marianelli
Cinzia
C
Ciuchini
Franco
F
Fasanella
Antonio
A
Adone
Rosanna
R
D000818:Animals; D000881:Anthrax / Q000382:microbiology / Q000517:prevention & control / Q000662:veterinary; D022122:Anthrax Vaccines; D001408:Bacillus anthracis / Q000145:classification / Q000235:genetics / Q000276:immunology / Q000472:pathogenicity*; D001426:Bacterial Proteins / Q000235:genetics*; D002417:Cattle; D015964:Gene Expression Regulation, Bacterial; D007558:Italy; D016133:Polymerase Chain Reaction / Q000379:methods; D017422:Sequence Analysis, DNA; D012756:Sheep; D014613:Vaccines, Attenuated; D014774:Virulence; D037521:Virulence Factors / Q000235:genetics*
D022122:Anthrax Vaccines; D001426:Bacterial Proteins; D014613:Vaccines, Attenuated; D037521:Virulence Factors