title: Gene expression profile of abdominal aortic aneurysm rupture.
abstract: To search for novel transcriptional pathways that are activated in abdominal aortic aneurysm rupture, cDNA microarrays were used to compare global mRNA expression at the aneurysm rupture edge to anterior sac, and selected results were confirmed using quantitative real-time-polymerase chain reaction (QRT-PCR). This study identified apoptosis, angiogenesis, and inflammation as potentially important participants during the process of aneurysm rupture.
authors.affiliation: Department of Cardiovascular Sciences, Academic Vascular Surgery Unit, St. George's, University of London, UK.
authors.forename: Edward
authors.initials: E
authors.lastname: Choke
authors.forename: Matthew M
authors.initials: MM
authors.lastname: Thompson
authors.forename: Alun
authors.initials: A
authors.lastname: Jones
authors.forename: Evelyn
authors.initials: E
authors.lastname: Torsney
authors.forename: Joseph
authors.initials: J
authors.lastname: Dawson
authors.forename: Kenneth
authors.initials: K
authors.lastname: Laing
authors.forename: Hosaam
authors.initials: H
authors.lastname: Nasr
authors.forename: Ian M
authors.initials: IM
authors.lastname: Loftus
authors.forename: Gillian W
authors.initials: GW
authors.lastname: Cockerill
mesh_terms: D017544:Aortic Aneurysm, Abdominal / Q000235:genetics*; D001019:Aortic Rupture / Q000235:genetics*; D015870:Gene Expression; D020869:Gene Expression Profiling; D006801:Humans; D020411:Oligonucleotide Array Sequence Analysis; D012333:RNA, Messenger / Q000235:genetics
chemical_list: D012333:RNA, Messenger