title: Investigating the existence of quantum metabolic values in non-Hodgkin's lymphoma by 2-deoxy-2-[F-18]fluoro-D-glucose positron emission tomography.
abstract: OBJECTIVE
  To investigate the existence of quantum metabolic values in various subtypes of non-Hodgkin's lymphoma (NHL).
  
  
  METHODS
  Fifty-eight patients with newly diagnosed NHL and positron emission tomography (PET) performed within three months of biopsy were included. The standardized uptake value (SUV) from PET over the area of biopsy and serum glucose [Glc] were recorded. The group glucose sensitivity(G) for indolent and aggressive NHL was obtained by linear regression with ln(SUV) = G x ln[Glc] + C, where C is a constant for the group. Finally, the individual's glucose sensitivity (g) was obtained by g = {ln(SUV)-C}/ln[Glc], along with their means in various subtypes of NHL. To further investigate the influence of extreme [Glc] conditions, the SUVs corrected by the individually calculated g at various glucose levels, [Glc'] using SUV' =SUV x {[Glc']/[Glc]}(g), were compared to the original SUVs for both indolent and aggressive NHL.
  
  
  RESULTS
  The averaged g (=G) for aggressive was significant different from that for indolent NHL (-0.94 +/- 0.51 vs. +0.13 +/- 0.10, respectively, p < 0.00005). There were significant differences in SUV for [Glc] < 80 or >110 mg/dl for both types of NHL. Unlike overlap among SUVs between NHL subtypes, the g value clearly categorized them into two distinct groups with positive (near-zero) and negative g values (around -1) for the indolent and aggressive NHLs, respectively.
  
  
  CONCLUSIONS
  Distinct quantum metabolic values of -1 and 0 were noted in NHL. Aggressive NHL has a more negative value (or higher glucose sensitivity) than that of indolent and, thus, is more susceptible to extreme glucose variation.
authors.affiliation: Positron Diagnostic Center and Cyclotron, Department of Nuclear Medicine, William Beaumont Hospital, 3601 W. Thirteen Mile Road, Royal Oak, MI 48073-6769, USA. owong@beaumont.edu
authors.forename: Ching-yee Oliver
authors.initials: CY
authors.lastname: Wong
authors.forename: Joseph
authors.initials: J
authors.lastname: Thie
authors.forename: Kelly J
authors.initials: KJ
authors.lastname: Parling-Lynch
authors.forename: Dana
authors.initials: D
authors.lastname: Zakalik
authors.forename: Regina H
authors.initials: RH
authors.lastname: Wong
authors.forename: Marianne
authors.initials: M
authors.lastname: Gaskill
authors.forename: Jeffrey H
authors.initials: JH
authors.lastname: Margolis
authors.forename: Jack
authors.initials: J
authors.lastname: Hill
authors.forename: Ammar
authors.initials: A
authors.lastname: Sukari
authors.forename: Surya
authors.initials: S
authors.lastname: Chundru
authors.forename: Darlene
authors.initials: D
authors.lastname: Fink-Bennett
authors.forename: Conrad
authors.initials: C
authors.lastname: Nagle
mesh_terms: D015331:Cohort Studies; D005260:Female; D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18 / Q000493:pharmacokinetics; D005947:Glucose / Q000378:metabolism; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000145:classification / Q000000981:diagnostic imaging* / Q000378:metabolism*; D008875:Middle Aged; D009367:Neoplasm Staging; D049268:Positron-Emission Tomography / Q000379:methods* / Q000592:standards; D011859:Radiography
chemical_list: D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D005947:Glucose