title: Development of new pyrrolopyrimidine-based inhibitors of Janus kinase 3 (JAK3).
abstract: A new class of bicyclic pyrrolopyrimidine-based Janus kinase 3 (JAK-3) inhibitors are described. Many of these inhibitors showed low nanomolar activity against JAK-3.
authors.affiliation: Procter and Gamble Pharmaceuticals, Health Care Research Center, 8700 Mason-Montgomery Road, Mason, OH 45040, USA. mclark@metastatix.com
authors.forename: Michael P
authors.initials: MP
authors.lastname: Clark
authors.forename: Kelly M
authors.initials: KM
authors.lastname: George
authors.forename: Roger G
authors.initials: RG
authors.lastname: Bookland
authors.forename: Jack
authors.initials: J
authors.lastname: Chen
authors.forename: Steven K
authors.initials: SK
authors.lastname: Laughlin
authors.forename: Kumar D
authors.initials: KD
authors.lastname: Thakur
authors.forename: Wenlin
authors.initials: W
authors.lastname: Lee
authors.forename: Jan R
authors.initials: JR
authors.lastname: Davis
authors.forename: Ed J
authors.initials: EJ
authors.lastname: Cabrera
authors.forename: Todd A
authors.initials: TA
authors.lastname: Brugel
authors.forename: John C
authors.initials: JC
authors.lastname: VanRens
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Laufersweiler
authors.forename: Jennifer A
authors.initials: JA
authors.lastname: Maier
authors.forename: Mark P
authors.initials: MP
authors.lastname: Sabat
authors.forename: Adam
authors.initials: A
authors.lastname: Golebiowski
authors.forename: Vijay
authors.initials: V
authors.lastname: Easwaran
authors.forename: Mark E
authors.initials: ME
authors.lastname: Webster
authors.forename: Biswanath
authors.initials: B
authors.lastname: De
authors.forename: George
authors.initials: G
authors.lastname: Zhang
mesh_terms: D001327:Autoimmune Diseases / Q000188:drug therapy; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D006801:Humans; D007109:Immunity / Q000187:drug effects; D053614:Janus Kinase 2 / Q000037:antagonists & inhibitors; D053616:Janus Kinase 3 / Q000037:antagonists & inhibitors*; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology; D011758:Pyrroles / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D011743:Pyrimidines; D011758:Pyrroles; D053614:Janus Kinase 2; D053616:Janus Kinase 3