Enantioseparation of extended metal atom chain complexes: unique compounds of extraordinarily high specific rotation.
Extended metal atom chains (EMACs) contain a linear metal chain wrapped by various ligands. Most complexes are of the form M(3)(dpa)(4)X(2), where M = metal, dpa = 2,2'-dipyridylamide, and X = various anions. The ligands form helical coils about the metal chain, which results in chiral EMAC complexes. The EMACs containing the metals Co and Cu were partially separated in polar organic mode using a vancomycin-based chiral stationary phase. Under similar conditions, two EMACs with Ni metal and varying anions could be baseline separated. The polar organic mode was used because of the instability of the compounds in aqueous mobile phases. Also, these conditions are more conducive to preparative separations. Polarimetric measurements on the resolved enantiomers of Ni(3)(dpa)(4)Cl(2) indicate that they have extraordinarily high specific rotations (on the order of 5000 deg cc/g dm).
Warnke
Molly M
MM
Department of Chemistry and Biochemistry, University of Texas at Arlington, Arlington, Texas 76019, USA.
Cotton
F Albert
FA
Armstrong
Daniel W
DW
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification*; D002851:Chromatography, High Pressure Liquid; D008670:Metals / Q000737:chemistry*; D009904:Optical Rotation; D013237:Stereoisomerism; D014640:Vancomycin / Q000737:chemistry / Q000302:isolation & purification*
D000900:Anti-Bacterial Agents; D008670:Metals; D014640:Vancomycin