title: Fungal metabolites of (E)-guggulsterone and their antibacterial and radical-scavenging activities.
abstract: Fungal transformation of (E)-guggulsterone (= (17E)-pregna-4,17-diene-3,16-dione; 1) by Rhizopus stolonifer, Fusarium lini, Cunninghamella elegans, or Gibberella fujikuroi afforded ten hydroxylated metabolites (2-11; Scheme), which were fully characterized. Compounds 4-11 have not been described yet. Some of these novel hydroxylated metabolites, as well as acetylated derivatives thereof, exhibited significant antibacterial and radical-scavenging activities (Table 3).
authors.affiliation: H. E. J. Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi-75270, Pakistan. hej@cyber.net.pk
authors.forename: M Iqbal
authors.initials: MI
authors.lastname: Choudhary
authors.forename: S Adnan Ali
authors.initials: SA
authors.lastname: Shah
authors.forename: Amtul
authors.initials: A
authors.lastname: Sami
authors.forename: Asma
authors.initials: A
authors.lastname: Ajaz
authors.forename: Farzana
authors.initials: F
authors.lastname: Shaheen
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D016166:Free Radical Scavengers / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D005658:Fungi / Q000378:metabolism*; D015394:Molecular Structure; D011282:Pregnenediones / Q000737:chemistry* / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D016166:Free Radical Scavengers; D011282:Pregnenediones; C023617:pregna-4,17-diene-3,16-dione