title: The role of plasmapheresis therapy for perioperative management in ABO-incompatible adult living donor liver transplantation.
abstract: BACKGROUND
  Although living donor liver transplantation (LDLT) was established as a treatment for end-stage liver disease in Japan, the indication for LDLT across an ABO-incompatible barrier remains controversial. The purpose of this study was to elucidate the role of plasmapheresis in incompatible LDLT.
  
  
  METHODS
  Eleven adult patients (seven men and four women) who underwent incompatible LDLT were enrolled in this study. Of these three patients had hepatocellular carcinoma, three chronic hepatitis C, one Wilson's disease, one autoimmune hepatitis, one chronic hepatitis B, one hemochromatosis, and one fulminant hepatic failure. The immunosuppressive regimen consisted of tacrolimus, prednisolone, mycophenolate mofetil (or cyclophosphamide), and prostaglandin E1 in all patients. Multiple plasmapheresis was performed perioperatively to reduce the recipient's antibody titers against the donor's blood type.
  
  
  RESULTS
  Plasmapheresis was useful for the reduction of the recipient's antibody titers to x 16 or lower before and after transplantation. There was no difference in transplant outcome between the 11 patients with incompatible blood group and 30 patients with identical or compatible blood groups.
  
  
  CONCLUSIONS
  Major postoperative complications such as intrahepatic biliary complications and hepatic necrosis may occur in incompatible transplantation. Several investigators suggested that anti-immunoglobulin (Ig) M and anti-IgG antibody titers sustained these complications. The antibody titers must be decreased sufficiently with plasmapheresis. An elevation of anti-ABO titers after transplantation may be a predictive risk factor for increased mortality and morbidity. In order to perform LDLT in a safer manner, plasmapheresis is an indispensable treatment to improve the outcome of ABO-incompatible cases.
authors.affiliation: Department of Surgery, Hachioji Medical Center of Tokyo Medical University, Tokyo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Ashizawa
authors.forename: N
authors.initials: N
authors.lastname: Matsuno
authors.forename: T
authors.initials: T
authors.lastname: Yokoyama
authors.forename: Y
authors.initials: Y
authors.lastname: Kihara
authors.forename: K
authors.initials: K
authors.lastname: Kuzuoka
authors.forename: S
authors.initials: S
authors.lastname: Taira
authors.forename: O
authors.initials: O
authors.lastname: Konno
authors.forename: Y
authors.initials: Y
authors.lastname: Jyojima
authors.forename: I
authors.initials: I
authors.lastname: Akashi
authors.forename: Y
authors.initials: Y
authors.lastname: Nakamura
authors.forename: K
authors.initials: K
authors.lastname: Hama
authors.forename: H
authors.initials: H
authors.lastname: Iwamoto
authors.forename: T
authors.initials: T
authors.lastname: Iwahori
authors.forename: T
authors.initials: T
authors.lastname: Nagao
authors.forename: M
authors.initials: M
authors.lastname: Kasahara
authors.forename: K
authors.initials: K
authors.lastname: Tanaka
mesh_terms: D000017:ABO Blood-Group System; D000328:Adult; D000368:Aged; D000917:Antibody Formation; D001787:Blood Group Incompatibility; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007165:Immunosuppression Therapy / Q000379:methods; D008107:Liver Diseases / Q000145:classification / Q000601:surgery; D016031:Liver Transplantation / Q000276:immunology / Q000379:methods* / Q000502:physiology; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D019990:Perioperative Care; D010956:Plasmapheresis; D012189:Retrospective Studies; D013156:Splenectomy
chemical_list: D000017:ABO Blood-Group System