Temperature effect on contractile activity of the Ambystoma dumerilii heart previously treated with isoproterenol.
The spontaneous heart rate (HR) and ventricular (V) and atrium (A) tensions (T) were evaluated through isolated organ assays at different temperatures in hearts from Ambystoma dumerilii control and treated with isoproterenol (ISO) [(150 mg/kg i.p. each 24 h, for 3 days)] on days 1, 5, 30 and 90 after ISO. In control hearts, the HR increased and the T decreased when temperature was augmented. One day after ISO the HR (43-24%) and T (50-25%) decreased with respect to control, between 8 and 24 degrees C. Five, 30 and 90 days after ISO, HR showed a gradual recovery with similar effect when the temperature was changed; but the AT increased and VT decreased at temperatures between 8 and 12 degrees C and were only recovered at temperatures above 12 degrees C. Our results indicate that the HR recovers after ISO in A. dumerilii independently of temperature. The recovery of AT and VT is similar to HR at temperatures higher than 12 degrees C and the increases in VT could be compensating the decrease in VT caused by ISO, at temperatures lower than 12 degrees C. The changes in heart contractile activity of A. dumerilii after insult show the thermic plasticity that is observed in ectothermic vertebrates.
Cano-Martínez
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Departamento de Fisiología, Instituto Nacional de Cardiología "Ignacio Chávez", Juan Badiano # 1, Colonia Sección XVI, Tlalpan, México D.F. 14080, Mexico. Electronic address: canagu@cardiologia.org.mx.
Vargas-González
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Departamento de Fisiología, Instituto Nacional de Cardiología "Ignacio Chávez", Juan Badiano # 1, Colonia Sección XVI, Tlalpan, México D.F. 14080, Mexico.
Guarner-Lans
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Departamento de Fisiología, Instituto Nacional de Cardiología "Ignacio Chávez", Juan Badiano # 1, Colonia Sección XVI, Tlalpan, México D.F. 14080, Mexico.
D000557:Ambystoma / Q000502:physiology*; D000818:Animals; D006321:Heart / Q000187:drug effects* / Q000502:physiology*; D006325:Heart Atria / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D006352:Heart Ventricles / Q000187:drug effects; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000494:pharmacology*; D009200:Myocardial Contraction / Q000187:drug effects*; D013696:Temperature
D007545:Isoproterenol