title: The effect of Crohn's disease on outcomes after restorative proctocolectomy.
abstract: OBJECTIVE
  This study was designed to compare postoperative adverse events and functional outcomes after ileal pouch-anal anastomosis between patients with Crohn's disease and those with non-Crohn's disease diagnoses.
  
  
  METHODS
  A literature search was performed to identify studies published between 1980 and 2005 comparing outcomes of patients undergoing ileal pouch-anal anastomosis for Crohn's disease, ulcerative colitis, and indeterminate colitis. Random-effect, meta-analytical techniques were used and sensitivity analysis was performed.
  
  
  RESULTS
  Ten studies comprising 3,103 patients (Crohn's disease=225; ulcerative colitis=2,711; indeterminate colitis=167) were included. Patients with Crohn's disease developed more anastomotic strictures than non-Crohn's disease diagnoses (odds ratio, 2.12; P=0.05) and experienced pouch failure more frequently than patients with ulcerative colitis (Crohn's disease vs. ulcerative colitis: 32 vs. 4.8 percent, P<0.001; Crohn's disease vs. indeterminate colitis: 38 vs. 5 percent, P<0.001). Urgency was more common in Crohn's disease compared with non-Crohn's disease: 19 vs. 11 percent (P=0.02). Incontinence occurred more frequently in Crohn's disease compared with non-Crohn's disease patients: 19 vs. 10 percent (odds ratio, 2.4; P=0.01). Twenty-four-hour stool frequency did not differ significantly between Crohn's disease, ulcerative colitis, or indeterminate colitis. Patients with isolated colonic Crohn's disease were not significantly at increased risk of postoperative complications or pouch failure (P=0.06).
  
  
  CONCLUSIONS
  Patients with Crohn's disease undergoing ileal pouch-anal anastomosis should be appropriately counseled toward poorer functional outcomes and higher failure compared with non-Crohn's disease patients. It maybe possible to preoperatively select patients with isolated colonic Crohn's disease who may benefit from ileal pouch-anal anastomosis with acceptable adverse outcomes.
authors.affiliation: Imperial College London, Department of Biosurgery and Surgical Technology, St Mary's Hospital, 10th Floor QEQM Building, Praed Street, London, UK.
authors.forename: George E
authors.initials: GE
authors.lastname: Reese
authors.forename: Richard E
authors.initials: RE
authors.lastname: Lovegrove
authors.forename: Henry S
authors.initials: HS
authors.lastname: Tilney
authors.forename: Takayuki
authors.initials: T
authors.lastname: Yamamoto
authors.forename: Alexander G
authors.initials: AG
authors.lastname: Heriot
authors.forename: Victor W
authors.initials: VW
authors.lastname: Fazio
authors.forename: Paris P
authors.initials: PP
authors.lastname: Tekkis
mesh_terms: D003424:Crohn Disease / Q000150:complications* / Q000601:surgery*; D003627:Data Interpretation, Statistical; D006801:Humans; D016737:Proctocolectomy, Restorative; D016896:Treatment Outcome