title: Animal models and brain circuits in drug addiction.
abstract: Animal models in the field of addiction are considered to be among the best available models of neuropsychiatric disease. These models have undergone a number of refinements that allow deeper understanding of the circuitry involved in initiating drug seeking and relapse. Notably, the demonstrable involvement of classic corticostriatal habit circuitry and the engagement of prefrontal cortical circuits in extinction training may have relevance to the therapeutic modulation of habit circuitry and drug addiction in humans.
authors.affiliation: Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29464, USA. kalivasp@musc.edu
authors.forename: Peter W
authors.initials: PW
authors.lastname: Kalivas
authors.forename: Jamie
authors.initials: J
authors.lastname: Peters
authors.forename: Lori
authors.initials: L
authors.lastname: Knackstedt
mesh_terms: D000818:Animals; D016739:Behavior, Addictive / Q000503:physiopathology; D001921:Brain / Q000503:physiopathology*; D003071:Cognition; D004195:Disease Models, Animal; D005108:Extinction, Psychological / Q000502:physiology; D006801:Humans; D019966:Substance-Related Disorders / Q000503:physiopathology*