Potential advantages of loco-regional intra-arterial chemotherapy.
Arterial infusion or perfusion are currently used to treat hepatic tumours, head and neck malignancy, melanomas and sarcomas of the limbs. An experimental study with epirubicin and cis-platinum infused into the hepatic artery was performed. Epirubicin was injected via the systemic vein or the hepatic artery in 27 rats. Cis-platinum was injected via a systemic route or the hepatic artery in 29 rats. Drug concentrations were evaluated in liver and tumour tissues. In the rats the tumour tissue drug concentration after hepatic artery infusion was 6- and 4-fold higher than with systemic infusion for epirubicin and cis-platinum, respectively. Arterial administration appeared to be better than systemic in terms of drug concentration within the tumours and systemic toxicity.
Cagol
Pier Paolo
PP
Semeiotica Chirurgica Unit, Department of Surgical Sciences, Faculty of Medicine, University of Udine, Italy. pierpaolo.cagol@uniud.it
Pasqual
Enricomaria
E
Bacchetti
Stefano
S
D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000493:pharmacokinetics / Q000627:therapeutic use*; D010478:Chemotherapy, Cancer, Regional Perfusion / Q000379:methods*; D002945:Cisplatin / Q000008:administration & dosage / Q000493:pharmacokinetics; D004195:Disease Models, Animal; D015251:Epirubicin / Q000008:administration & dosage / Q000493:pharmacokinetics; D006499:Hepatic Artery; D007261:Infusions, Intra-Arterial / Q000379:methods*; D007275:Injections, Intravenous; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D008114:Liver Neoplasms, Experimental / Q000188:drug therapy* / Q000378:metabolism / Q000556:secondary; D009368:Neoplasm Transplantation; D051381:Rats; D017207:Rats, Sprague-Dawley
D015251:Epirubicin; D002945:Cisplatin