title: Total ghrelin plasma level in patients with the restrictive type of anorexia nervosa.
abstract: Ghrelin is produced mainly in the stomach and is an essential link of the brain-gut axis. Ghrelin stimulates hunger centers in hypothalamus controlling food intake and body mass gain. The aim of the study is to analyze the total ghrelin plasma level in patients suffering from restrictive type of anorexia nervosa (AN-R). According to DSM-IV classification a group of 30 AN-R patients was investigated before and after 3 and 6 months of therapy. Therapy included normocaloric diet and cognitive-behavioral psychotherapy (CBT). The control group consisted of 20 girls without any eating disorders. Before the therapy the total ghrelin plasma level in AN-R patients was significantly higher than in the control group. After 3 and 6 months of treatment the total ghrelin plasma level in AN-R patients was significantly lower than in the control group. In AN-R patients, the total ghrelin plasma level is connected with the pathological feeding behavior.
authors.affiliation: Department and Clinic of Psychiatry and Psychotherapy, Medical University of Silesia, Katowice, ul. Ziolowa 45/47, 40-635 Katowice, Poland. mkozik@centrum-pediatrii.com.pl
authors.forename: Malgorzata
authors.initials: M
authors.lastname: Janas-Kozik
authors.forename: Irena
authors.initials: I
authors.lastname: Krupka-Matuszczyk
authors.forename: Izabela
authors.initials: I
authors.lastname: Malinowska-Kolodziej
authors.forename: Joanna
authors.initials: J
authors.lastname: Lewin-Kowalik
mesh_terms: D000293:Adolescent; D000328:Adult; D000856:Anorexia Nervosa / Q000097:blood* / Q000178:diet therapy / Q000628:therapy; D015992:Body Mass Index; D001068:Feeding and Eating Disorders / Q000097:blood; D005260:Female; D054439:Ghrelin; D006801:Humans; D036361:Peptide Hormones / Q000097:blood*
chemical_list: D054439:Ghrelin; D036361:Peptide Hormones