title: Decreased expression of tumor protein p53-induced nuclear protein 1 (TP53INP1) in breast carcinoma.
abstract: BACKGROUND
  Tumor protein p53-induced nuclear protein 1 (TP53INP1) is a stress-induced protein and plays a role in cell cycle arrest and p53-mediated apoptosis. In this study, TP53INP1 expression in human breast carcinoma was investigated.
  
  
  METHODS
  TP53INP1 and aberrant p53 expression were investigated immunohistochemically in 81 cases of breast carcinoma.
  
  
  RESULTS
  Diffuse and intense TP53INP1 expression was observed in the normal mammary gland. Decreased TP53INP1 expression was found in 45 cases (55.6%) of breast carcinoma. The TP53INP1 expression level was inversely linked to tumor size, positive lymph node metastasis, high histological grade and aberrant p53 expression.
  
  
  CONCLUSIONS
  Decreased expression of TP53INP1 is involved in breast carcinoma progression.
authors.affiliation: Department of Surgery, Kuma Hospital, 8-2-35, Shimoyamate-Dori, Chuo-ku, Kobe City, 650-0011, Japan. ito01@kuma-h.or.jp
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Ito
authors.forename: Yoshiharu
authors.initials: Y
authors.lastname: Motoo
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yoshida
authors.forename: Juan Lucio
authors.initials: JL
authors.lastname: Iovanna
authors.forename: Yuuki
authors.initials: Y
authors.lastname: Takamura
authors.forename: Akihiro
authors.initials: A
authors.lastname: Miya
authors.forename: Kanji
authors.initials: K
authors.lastname: Kuma
authors.forename: Akira
authors.initials: A
authors.lastname: Miyauchi
mesh_terms: D001943:Breast Neoplasms / Q000235:genetics*; D002352:Carrier Proteins / Q000235:genetics*; D005260:Female; D006360:Heat-Shock Proteins / Q000235:genetics*; D006801:Humans; D007150:Immunohistochemistry
chemical_list: D002352:Carrier Proteins; D006360:Heat-Shock Proteins; C429767:TP53INP1 protein, human