title: Collapsin response mediator protein 1 mediates reelin signaling in cortical neuronal migration.
abstract: Collapsin response mediator protein 1 (CRMP1) is one of the CRMP family members that mediates signal transduction of axon guidance molecules. Here, we show evidence that CRMP1 is involved in Reelin (Reln) signaling to regulate neuronal migration in the cerebral cortex. In crmp1-/- mice, radial migration of cortical neurons was retarded. This phenotype was not observed in the sema3A-/- and crmp1+/-;sema3A+/- cortices. However, CRMP1 was colocalized with disabled-1 (Dab1), an adaptor protein in Reln signaling. In the Reln(rl/rl) cortex, CRMP1 and Dab1 were expressed at a higher level, yet tyrosine phosphorylated at a lower level. Loss of crmp1 in a dab1 heterozygous background led to the disruption of hippocampal lamination, a Reeler-like phenotype. In addition to axon guidance, CRMP1 regulates neuronal migration by mediating Reln signaling.
authors.affiliation: Department of Molecular Pharmacology and Neurobiology, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan.
authors.forename: Naoya
authors.initials: N
authors.lastname: Yamashita
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Uchida
authors.forename: Toshio
authors.initials: T
authors.lastname: Ohshima
authors.forename: Syu-ichi
authors.initials: S
authors.lastname: Hirai
authors.forename: Fumio
authors.initials: F
authors.lastname: Nakamura
authors.forename: Masahiko
authors.initials: M
authors.lastname: Taniguchi
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Mikoshiba
authors.forename: Jérôme
authors.initials: J
authors.lastname: Honnorat
authors.forename: Pappachan
authors.initials: P
authors.lastname: Kolattukudy
authors.forename: Nicole
authors.initials: N
authors.lastname: Thomasset
authors.forename: Kohtaro
authors.initials: K
authors.lastname: Takei
authors.forename: Takuya
authors.initials: T
authors.lastname: Takahashi
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Goshima
mesh_terms: D000818:Animals; D015816:Cell Adhesion Molecules, Neuronal / Q000235:genetics / Q000502:physiology*; D002460:Cell Line; D002465:Cell Movement / Q000235:genetics / Q000502:physiology*; D002540:Cerebral Cortex / Q000166:cytology / Q000502:physiology*; D016326:Extracellular Matrix Proteins / Q000235:genetics / Q000502:physiology*; D006801:Humans; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D008818:Mice, Neurologic Mutants; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000502:physiology*; D009474:Neurons / Q000166:cytology / Q000502:physiology*; D010750:Phosphoproteins / Q000235:genetics / Q000502:physiology*; D000091042:Reelin Protein; D012697:Serine Endopeptidases / Q000235:genetics / Q000502:physiology*; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology*; D000098855:Collapsin Response Mediator Protein 1
chemical_list: D015816:Cell Adhesion Molecules, Neuronal; D016326:Extracellular Matrix Proteins; D009419:Nerve Tissue Proteins; D010750:Phosphoproteins; D000091042:Reelin Protein; D000098855:Collapsin Response Mediator Protein 1; C000717127:RELN protein, human; C000717128:Reln protein, mouse; D012697:Serine Endopeptidases