Sinusoidal swinging dynamics of the telomere repair and cell growth activation functions of telomerase in rat liver cancer cells.
Telomerase is a multimolecular complex of reverse transcriptase, RNA template, and regulatory proteins. It has two known functions: catalysis of the addition of [TTAGGG] repeats to telomeric DNA and the activation of various genes controlling cell proliferation. The possible coordination of these two functions is a key issue in understanding the growth of cancer cells. We report long-term changes to this complex system, as shown by specific data analysis methods. We show that the dynamics of the two functions of telomerase are tightly linked, with a change in predominant function every 13-14 weeks. The conservative behavior of this dynamic system probably accounts for the persistent proliferation of cancer cells.
Wolfrom
Claire
C
CNRS-UMR 8080 Développement et Evolution, Bâtiment 440, Université Paris-Sud Orsay, F-91405 Orsay, France. claire.wolfrom@ibaic.u-psud.fr
Martin
Olivier C
OC
Laurent
Michel
M
Deschatrette
Jean
J
D000818:Animals; D001683:Biological Clocks; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D008113:Liver Neoplasms / Q000235:genetics / Q000378:metabolism*; D008954:Models, Biological; D009363:Neoplasm Proteins / Q000378:metabolism*; D051381:Rats; D019098:Telomerase / Q000235:genetics / Q000378:metabolism*; D016615:Telomere / Q000235:genetics / Q000378:metabolism*; D013997:Time Factors
D009363:Neoplasm Proteins; D019098:Telomerase