title: Past-users of HRT are osteopenic four months after discontinuation:an observational and cross-sectional study.
abstract: Hormonal replacement therapy (HRT) helps to prevent osteoporosis. The effect of short-term discontinuation of a long-term HRT on bone mineral density (BMD) in healthy post-menopausal women is unknown. Fifteen women on HRT (HRT users), 17 who never used HRT (non-users) and 8 former HRT users (past-HRT users) were recruited. BMD was measured by DXA. Our results allow to hypothesize that BMD may decline after short-term HRT discontinuation, which would increase the fracture risks. Indeed, our results show that past-HRT users are osteopenic just as non-users. However, these results should be re-examined using a prospective trial and a larger sample size.
authors.affiliation: Research Centre on Aging, Faculty of Physical Education and Sports, University of Sherbrooke, Sherbrooke, Québec, Canada.
authors.forename: Mylène
authors.initials: M
authors.lastname: Aubertin-Leheudre
authors.forename: Michel O
authors.initials: MO
authors.lastname: Mèlançon
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Chaput
authors.forename: Isabelle J
authors.initials: IJ
authors.lastname: Dionne
mesh_terms: D015502:Absorptiometry, Photon; D000368:Aged; D015519:Bone Density; D003430:Cross-Sectional Studies; D015914:Estrogen Replacement Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000517:prevention & control*; D017698:Postmenopause; D012307:Risk Factors; D011795:Surveys and Questionnaires; D028761:Withholding Treatment; D016387:Women's Health