title: Biocatalytically induced formation of cupric ferrocyanide nanoparticles and their application for electrochemical and optical biosensing of glucose.
abstract: The enzymatically controlled growth of cupric ferrocyanide nanoparticles in the presence of glucose oxidase, its ferricyanide electron acceptor, and copper ions is described. The biocatalytically stimulated growth of these nanoparticles on the surface of carbon-paste electrodes results in an amplified electrochemical detection of the glucose substrate. This concept can readily be expanded for monitoring a wide range of biocatalytic processes involving the ferricyanide electron acceptor.
authors.affiliation: Department of Chemical & Materials Engineering, Center for Bioelectronics and Biosensors, Biodesign Institute, Arizona State University, Tempe, Arizona 85287-5801, USA. joseph.wang@asu.edu
authors.forename: Joseph
authors.initials: J
authors.lastname: Wang
authors.forename: Alberto
authors.initials: A
authors.lastname: Sánchez Arribas
mesh_terms: D001704:Biopolymers / Q000737:chemistry*; D015374:Biosensing Techniques / Q000295:instrumentation / Q000379:methods*; D002384:Catalysis; D020099:Coated Materials, Biocompatible / Q000737:chemistry; D003460:Crystallization / Q000379:methods; D004563:Electrochemistry / Q000379:methods*; D004800:Enzymes, Immobilized / Q000737:chemistry; D005295:Ferrocyanides / Q000737:chemistry*; D005947:Glucose / Q000032:analysis* / Q000737:chemistry; D005949:Glucose Oxidase / Q000737:chemistry*; D008422:Materials Testing; D008839:Microelectrodes; D008968:Molecular Conformation; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure; D036103:Nanotechnology / Q000379:methods; D055095:Optics and Photonics; D010316:Particle Size; D013499:Surface Properties
chemical_list: D001704:Biopolymers; D020099:Coated Materials, Biocompatible; D004800:Enzymes, Immobilized; D005295:Ferrocyanides; C039105:cupric ferrocyanide; D005949:Glucose Oxidase; D005947:Glucose