title: [Drug binding to blood proteins: characteristics, roles and pathophysiological changes].
abstract: HSA and AGP are the only plasma proteins capable of binding drugs through specific sites with high affinity. As such, they can limit drug distribution and, sometimes, drug elimination. Such binding is called restrictive. Low binding capacities are said to be permissive, as they do not lead to drug retention. Modifications of restrictive binding can influence other pharmacokinetic parameters and also have clinical implications.
authors.affiliation: Unité Fonctionnelle de Pharmacologie et Toxicologie, CHIC, 40 Avenue de Verdun, F-94010 Creteil. jpmtillement@hotmail.com
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Tillement
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Duché
authors.forename: Jérôme
authors.initials: J
authors.lastname: Barré
mesh_terms: D001798:Blood Proteins / Q000378:metabolism*; D006801:Humans; D008074:Lipoproteins / Q000378:metabolism; D009961:Orosomucoid / Q000378:metabolism; D004364:Pharmaceutical Preparations / Q000097:blood / Q000378:metabolism*; D010599:Pharmacokinetics; D011485:Protein Binding; D012709:Serum Albumin / Q000378:metabolism
chemical_list: D001798:Blood Proteins; D008074:Lipoproteins; D009961:Orosomucoid; D004364:Pharmaceutical Preparations; D012709:Serum Albumin