title: Two novel glycosidic triterpene alkaloids from the stem barks of Machilus yaoshansis.
abstract: [structure: see text] Two unusual glycosidic triterpene alkaloids, machilaminosides A (1) and B (2), have been isolated from the stem barks of Machilus yaoshansis. Their structures were elucidated by detailed spectroscopic analysis. A possible biogenetic origin of 1 and 2 mediated by the coupling of 2-O-beta-D-glucopyranosyl-cucurbitacin I, respectively, with urea and adenosine was postulated. 1 and 2 showed nonselective cytotoxic activities against several human cancer cell lines as well as TNF-alpha secretion inhibitory activities.
authors.affiliation: Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Beijing, People's Republic of China.
authors.forename: Ming-Tao
authors.initials: MT
authors.lastname: Liu
authors.forename: Sheng
authors.initials: S
authors.lastname: Lin
authors.forename: Ying-Hong
authors.initials: YH
authors.lastname: Wang
authors.forename: Wen-Yi
authors.initials: WY
authors.lastname: He
authors.forename: Shuai
authors.initials: S
authors.lastname: Li
authors.forename: Su-Juan
authors.initials: SJ
authors.lastname: Wang
authors.forename: Yong-Chun
authors.initials: YC
authors.lastname: Yang
authors.forename: Jian-Gong
authors.initials: JG
authors.lastname: Shi
mesh_terms: D000470:Alkaloids / Q000096:biosynthesis / Q000737:chemistry*; D006027:Glycosides / Q000096:biosynthesis / Q000737:chemistry*; D019770:Lauraceae / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D024301:Plant Bark / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry*
chemical_list: D000470:Alkaloids; D006027:Glycosides; D014315:Triterpenes; C517122:machilaminoside A; C517121:machilaminoside B