The "domino theory" of hunger: the hypothalamus is hot.
Mechanisms by which the hypothalamus senses nutritional status are important for many metabolic diseases, including obesity and diabetes. Now, report that hypothalamic neurons sense nutritional deficit through a cascade of events involving leptin, corticosterone, and glial production of thyroid hormone, leading to neuronal induction of uncoupling protein.
Mobbs
Charles V
CV
Department of Neuroscience and Department of Geriatrics, Mount Sinai School of Medicine, New York, NY 10029, USA. charles.mobbs@mssm.edu
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D004734:Energy Metabolism; D005215:Fasting; D006815:Hunger; D007031:Hypothalamus / Q000166:cytology / Q000378:metabolism*; D007473:Ion Channels / Q000378:metabolism; D020738:Leptin / Q000378:metabolism; D051379:Mice; D024101:Mitochondrial Proteins / Q000378:metabolism; D009474:Neurons / Q000378:metabolism*; D022722:Thermogenesis; D014284:Triiodothyronine / Q000378:metabolism; D000071246:Uncoupling Protein 2
D007473:Ion Channels; D020738:Leptin; D024101:Mitochondrial Proteins; D000071246:Uncoupling Protein 2; D014284:Triiodothyronine; D000255:Adenosine Triphosphate