Histopathologic abnormalities of the lymphoreticular tissues in organic cation transporter 2 deficiency: evidence for impaired B cell maturation.
Immunohistology of lymphoreticular tissues of a fatal case of organic cation transporter 2 deficiency revealed inhibited proliferation with increased apoptosis in the germinal centers, resulting in "burned out" follicles. This is indicative of impaired antigen driven B cell affinity maturation. Defective humoral immune response might explain the recurrent infections in untreated organic cation transporter 2 deficiency.
Komlósi
Katalin
K
Department of Medical Genetics and Child Development, University of Pécs, Pécs, Hungary.
Havasi
Viktória
V
Bene
Judit
J
Süle
Norbert
N
Pajor
László
L
Nicolai
Raffaella
R
Benatti
Paola
P
Calvani
Menotti
M
Melegh
Béla
B
D001402:B-Lymphocytes / Q000473:pathology*; D049108:Cell Enlargement; D049109:Cell Proliferation; D002675:Child, Preschool; D018450:Disease Progression; D006801:Humans; D007223:Infant; D008221:Lymphoid Tissue / Q000378:metabolism / Q000473:pathology*; D008297:Male; D027701:Organic Cation Transport Proteins / Q000172:deficiency*; D012141:Respiratory Tract Infections / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D000074058:Solute Carrier Family 22 Member 5
D027701:Organic Cation Transport Proteins; C492020:SLC22A5 protein, human; D000074058:Solute Carrier Family 22 Member 5