Role of the HLA-DQ locus in the development of chronic gastritis and gastric carcinoma in Mexican patients.
OBJECTIVE
To determine the HLA-DQ locus in Mexican patients with Chronic gastritis and gastric adenocarcinoma.


METHODS
Oligotyping for HLA-DQ locus was performed in 45 Mexican patients with chronic gastritis and 13 Mexican patients with diffuse-type gastric adenocarcinoma, and was then compared with 99 clinically healthy unrelated individuals. H pylori infection and CagA status were assessed in patients by enzyme-linked immunosorbent assay (ELISA) method.


RESULTS
We found a significant increased frequency of HLA-DQB1*0401 allele in H pylori-positive patients with chronic gastritis when compared with healthy subjects [19 vs 0%, P = 1 x 10(-7), odds ratio (OR) = 4.96; 95% confidence interval (95% CI), 3.87-6.35]. We also found a significant increased frequency of HLA-DQB1*0501 in patients with diffuse-type gastric carcinoma in comparison with healthy individuals (P = 1 x 10(-6), OR = 13.07; 95% CI, 2.82-85.14).


CONCLUSIONS
HLA-DQ locus may play a different role in the development of H pylori-related chronic gastritis and diffuse-type gastric adenocarcinoma in the Mexican Mestizo population.
Herrera-Goepfert
Roberto
R
Department of Pathology, Instituto Nacional de Cancerologia, Mexico City, Mexico. rhgoepfert@yahoo.com.mx
Yamamoto-Furusho
Jesus-K
JK
Onate-Ocana
Luis-F
LF
Camorlinga-Ponce
Margarita
M
Munoz
Leopoldo
L
Ruiz-Morales
Jorge-A
JA
Vargas-Alarcon
Gilberto
G
Granados
Julio
J
D000230:Adenocarcinoma / Q000208:ethnology / Q000235:genetics*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002908:Chronic Disease; D005260:Female; D005756:Gastritis / Q000235:genetics*; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000208:ethnology / Q000235:genetics; D005838:Genotype; D006683:HLA-DQ Antigens / Q000235:genetics*; D006801:Humans; D008297:Male; D008800:Mexico / Q000208:ethnology; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000208:ethnology / Q000235:genetics*
D006683:HLA-DQ Antigens