c-Fos-deficient mice are susceptible to Salmonella enterica serovar Typhimurium infection.
c-Fos is a component of transcription factor AP-1. We show that macrophages lacking c-Fos exhibit enhanced production of proinflammatory cytokines, potentiated NF-kappaB phosphorylation, and increased cell death following Salmonella enterica serovar Typhimurium infection. Furthermore, mice lacking c-Fos are highly susceptible to infection, suggesting that c-Fos confers resistance to Salmonella infection in mice.
Maruyama
Kenta
K
Department of Microbiology and Immunology, School of Medicine, Keio University, 160-8582 Tokyo, Japan.
Sano
Gen-Ichiro
G
Ray
Neelanjan
N
Takada
Yasunari
Y
Matsuo
Koichi
K
D000818:Animals; D020022:Genetic Predisposition to Disease; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D016760:Proto-Oncogene Proteins c-fos / Q000172:deficiency* / Q000235:genetics*; D012480:Salmonella Infections / Q000276:immunology* / Q000382:microbiology; D012486:Salmonella typhimurium / Q000276:immunology
D016760:Proto-Oncogene Proteins c-fos