title: Differential expression of decorin in localized scleroderma following ultraviolet-A1 irradiation.
abstract: Patients with localized scleroderma underwent an 8-week course of ultraviolet A1 phototherapy. At baseline, decorin levels of lesional skin were significantly lower than those of nonlesional skin and healthy control subjects. After ultraviolet A1 phototherapy, decorin levels of lesional skin were significantly higher than baseline. Decorin may be of significance in the pathogenesis of localized scleroderma.
authors.affiliation: Department of Dermatology, Ruhr-University Bochum, Bochum, Germany. t.gambichler@klinikum-bochum.de
authors.forename: Thilo
authors.initials: T
authors.lastname: Gambichler
authors.forename: Marina
authors.initials: M
authors.lastname: Skrygan
authors.forename: Nordwig S
authors.initials: NS
authors.lastname: Tomi
authors.forename: Peter
authors.initials: P
authors.lastname: Altmeyer
authors.forename: Alexander
authors.initials: A
authors.lastname: Kreuter
mesh_terms: D000328:Adult; D058575:Decorin; D016326:Extracellular Matrix Proteins / Q000378:metabolism*; D005260:Female; D006801:Humans; D008875:Middle Aged; D010789:Phototherapy; D011509:Proteoglycans / Q000378:metabolism*; D045745:Scleroderma, Limited / Q000378:metabolism* / Q000628:therapy; D012867:Skin / Q000378:metabolism*
chemical_list: C546878:DCN protein, human; D058575:Decorin; D016326:Extracellular Matrix Proteins; D011509:Proteoglycans