Biocompatability of hydroxyapatite composite as a local drug delivery system.
OBJECTIVE
To investigate the biocompatibility of hydroxyapatite composite (hydroxyapatite, plaster of Paris, and chitosan) impregnated with gentamicin, fosfomycin, imipenem, or amphotericin B.


METHODS
The interactions of the extract from each drug against osteoblast were tested using the methylthiotetrazole test.


RESULTS
Extracts from all drugs showed good biocompatibility at concentrations varying from 10 microgram/ml to 1000 microgram/ml. Imipenem and amphotericin B at a concentration of 1000 microgram/ml had a significantly higher percentage of cell viability than the control group. No morphological change of osteoblast was observed in all drug tests at any concentrations.


CONCLUSIONS
The hydroxyapatite composite had a good biocompatibility for carrying gentamicin, fosfomycin, imipenem, or amphotericin B.
Krisanapiboon
A
A
Department of Orthopaedic and Physical Medicine, Faculty of Medicine, Prince of Songkla University, Haadyai, Songkhla, Thailand.
Buranapanitkit
B
B
Oungbho
K
K
D000666:Amphotericin B / Q000008:administration & dosage; D001672:Biocompatible Materials; D002133:Calcium Sulfate; D048271:Chitosan; D016503:Drug Delivery Systems; D017886:Durapatite; D005578:Fosfomycin / Q000008:administration & dosage; D005839:Gentamicins / Q000008:administration & dosage; D006801:Humans; D015378:Imipenem / Q000008:administration & dosage; D010006:Osteoblasts / Q000187:drug effects
D001672:Biocompatible Materials; D005839:Gentamicins; D005578:Fosfomycin; D015378:Imipenem; D000666:Amphotericin B; D048271:Chitosan; D017886:Durapatite; D002133:Calcium Sulfate