The mouse as a model for human biology: a resource guide for complex trait analysis.
The mouse has been a powerful force in elucidating the genetic basis of human physiology and pathophysiology. From its beginnings as the model organism for cancer research and transplantation biology to the present, when dissection of the genetic basis of complex disease is at the forefront of genomics research, an enormous and remarkable mouse resource infrastructure has accumulated. This review summarizes those resources and provides practical guidelines for their use, particularly in the analysis of quantitative traits.
Peters
Luanne L
LL
The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA. luanne.peters@jax.org
Robledo
Raymond F
RF
Bult
Carol J
CJ
Churchill
Gary A
GA
Paigen
Beverly J
BJ
Svenson
Karen L
KL
D000818:Animals; D030541:Databases, Genetic; D023281:Genomics; D006801:Humans; D051379:Mice; D008815:Mice, Inbred Strains / Q000235:genetics; D008817:Mice, Mutant Strains / Q000235:genetics; D008957:Models, Genetic; D016296:Mutagenesis; D040641:Quantitative Trait Loci