title: [Multifocal ischaemic stroke and myocardial infarction in a woman with occult lung cancer complicated with chronic DIC and thrombotic endocarditis].
abstract: Ischaemic stroke in thromboembolic mechanism may be a first sign of neoplastic disease, as in the presented case of a 56-year-old woman. Progressive trombocytopenia, anaemia with reticulocytosis and schistocytes in peripheral blood smear, elevated serum LDH activity as well as coexisting myocardial infarction initially suggested Moschcowitz syndrome. However, plasma exchange did not improve her neurological status and D-dimer values increase in subsequent evaluations indicated chronic DIC. At the same time, on transesophageal echocardiography, thrombotic endocarditis was diagnosed. Screening for cancer showed high CA 125 marker and chest computed tomography revealed lung tumor, not visible on earlier chest X-ray. In further treatment she underwent palliative radiotherapy and continued low molecular weight heparin. The neoplastic process had an unfavorable course and she died after four months. The authors point out that in case of multifocal ischaemic stroke and coexistent thrombocytopenia, neoplastic hypercoagulable state and thrombotic endocarditis should be considered.
authors.affiliation: Oddział Chorób Wewnetrznych, Szpital Miejski, ZOZ Poznań-Nowe Miasto, Poznañ, Poland. welikowski@wp.pl
authors.forename: Waldemar
authors.initials: W
authors.lastname: Elikowski
authors.forename: Krystyna
authors.initials: K
authors.lastname: Maka
authors.forename: Krzysztofa
authors.initials: K
authors.lastname: Ból
authors.forename: Ireneusz
authors.initials: I
authors.lastname: Jedliński
authors.forename: Maria
authors.initials: M
authors.lastname: Kubaszewska
mesh_terms: D002908:Chronic Disease; D004696:Endocarditis / Q000150:complications*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications* / Q000000981:diagnostic imaging* / Q000628:therapy; D008875:Middle Aged; D009203:Myocardial Infarction / Q000209:etiology*; D011859:Radiography; D020521:Stroke / Q000209:etiology*; D013927:Thrombosis / Q000150:complications*