The lymphopenic mouse in immunology: from patron to pariah.
A recent surge of interest in the behavior of T and B cells in lymphopenic model systems has resurrected a certain cynicism about the validity of using such models to answer important immunological questions. Here we discuss this skepticism in a broader historical context.
Singh
Nevil J
NJ
Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health, 4 / 111 Center Drive, MSC-0420, Bethesda, Maryland 20892, USA.
Schwartz
Ronald H
RH
D019264:Adoptive Transfer; D000818:Animals; D001402:B-Lymphocytes / Q000528:radiation effects; D004195:Disease Models, Animal; D008231:Lymphopenia; D051379:Mice; D018448:Models, Immunological; D013601:T-Lymphocytes / Q000528:radiation effects