title: Increased omega complexity and decreased microstate duration in nonmedicated schizophrenic patients.
abstract: To explore brain functions in schizophrenic patients, the global analytic strategy of multichannel EEG was performed that combines measures of global complexity (Omega), total power (Sigma) and generalized frequency (Phi), and EEG microstate analysis was applied to multichannel EEG data for 24 nonmedicated patients and 24 healthy subjects. The patients had higher Omega and Sigma values, and lower Phi values compared with healthy subjects. Three topographical classes were obtained from all EEG data by EEG microstate analysis. The mean duration of one topographical class in the patients was shortened compared to healthy subjects. These results indicated looser cooperativity, or decreased connectivity of the active brain process and deviant brain information processing in schizophrenic patients.
authors.affiliation: Department of Neuropsychiatry, Kansai Medical University, 10-15 Fumizono-cho, Moriguchi 570-8506, Japan. irisawas@takii.kmu.ac.jp
authors.forename: Satoshi
authors.initials: S
authors.lastname: Irisawa
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Isotani
authors.forename: Takami
authors.initials: T
authors.lastname: Yagyu
authors.forename: Sachi
authors.initials: S
authors.lastname: Morita
authors.forename: Keiichiro
authors.initials: K
authors.lastname: Nishida
authors.forename: Keizo
authors.initials: K
authors.lastname: Yamada
authors.forename: Masafumi
authors.initials: M
authors.lastname: Yoshimura
authors.forename: Gaku
authors.initials: G
authors.lastname: Okugawa
authors.forename: Kenji
authors.initials: K
authors.lastname: Nobuhara
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Kinoshita
mesh_terms: D000293:Adolescent; D000328:Adult; D001921:Brain / Q000503:physiopathology*; D001931:Brain Mapping; D004569:Electroencephalography; D005260:Female; D006801:Humans; D008297:Male; D012559:Schizophrenia / Q000503:physiopathology*; D012565:Schizophrenic Psychology; D013057:Spectrum Analysis