Cyclic AMP-dependent memory mutants are defective in the food choice behavior of Drosophila.
Acute choice behavior in ingesting two different concentrations of sucrose in Drosophila is presumed to include learning and memory. Effects on this behavior were examined for four mutations that block associative learning (dunce, rutabaga, amnesiac, and radish). Three of these mutations cause cyclic AMP signaling defects and significantly reduced taste discrimination. The exception was radish, which affects neither. Electrophysiological recordings confirmed that the sensitivity of taste receptors is almost indistinguishable in all flies, whether wild type or mutant. These results suggest that food choice behavior in Drosophila involves central nervous learning and memory operating via cyclic AMP signaling pathways.
Motosaka
Katsunori
K
Department of Developmental Biology and Neuroscience, Graduate School of Life Sciences, Tohoku University, Sendai 980-8578, Japan.
Koganezawa
Masayuki
M
Narikawa
Satoko
S
Furuyama
Akira
A
Shinozaki
Kenji
K
Isono
Kunio
K
Shimada
Ichiro
I
D000262:Adenylyl Cyclases / Q000235:genetics / Q000378:metabolism; D000704:Analysis of Variance; D000818:Animals; D002755:Choice Behavior / Q000502:physiology*; D000242:Cyclic AMP / Q000235:genetics / Q000378:metabolism*; D004193:Discrimination Learning / Q000502:physiology; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism*; D004331:Drosophila melanogaster / Q000235:genetics / Q000378:metabolism*; D005247:Feeding Behavior / Q000502:physiology; D005518:Food Preferences / Q000502:physiology*; D008568:Memory / Q000502:physiology; D009154:Mutation; D009479:Neuropeptides / Q000235:genetics / Q000378:metabolism; D010750:Phosphoproteins / Q000235:genetics / Q000378:metabolism; D015290:Second Messenger Systems / Q000235:genetics / Q000502:physiology; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology; D018709:Statistics, Nonparametric
D029721:Drosophila Proteins; D009479:Neuropeptides; D010750:Phosphoproteins; C093565:amn protein, Drosophila; C515827:rad protein, Drosophila; D000242:Cyclic AMP; D000262:Adenylyl Cyclases; C479926:Rut protein, Drosophila