title: [Multimodalities imaging for target volume definition in radiotherapy].
abstract: Modern radiotherapy delivery nowadays relies on tridimensional, conformal techniques. The aim is to better target the tumor while decreasing the dose administered to surrounding normal tissues. Gold standard imaging modality remains computed-tomography (CT) scanner. However, the intrinsic lack of contrast between soft tissues leads to high variabilities in target definition. The risks are : a geographical miss with tumor underirradiation on the one hand, and a tumor overestimation with undue normal tissues irradiation on the other hand. Alternative imaging modalities like magnetic resonance imaging and functional positron emission tomography could theoretically overcome the lack of soft tissues contrast of CT. However, the fusion of the different imaging modalities images requires the use of sophisticated computer algorithms. We will briefly review them. We will then review the different clinical results reported with multi-modalities imaging for tumors of the head, neck, lung, esophagus, cervix and lymphomas. Finally, we will briefly give practical recommendations for multi-modality imaging in radiotherapy treatment planning process.
authors.affiliation: Service de radiothérapie oncologique et Unité d'imagerie moléculaire et de radiothérapie expérimentale (IMRE), Cliniques universitaires Saint-Luc, avenue Hippocrate, 10, B-1200 Bruxelles, Belgique.
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Daisne
authors.forename: Vincent
authors.initials: V
authors.lastname: Grégoire
mesh_terms: D000465:Algorithms; D001932:Brain Neoplasms / Q000175:diagnosis / Q000532:radiotherapy; D002289:Carcinoma, Non-Small-Cell Lung / Q000175:diagnosis / Q000532:radiotherapy; D003952:Diagnostic Imaging / Q000379:methods / Q000592:standards; D004938:Esophageal Neoplasms / Q000175:diagnosis / Q000532:radiotherapy; D005260:Female; D006258:Head and Neck Neoplasms / Q000175:diagnosis / Q000532:radiotherapy; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis / Q000532:radiotherapy; D008223:Lymphoma / Q000175:diagnosis; D008279:Magnetic Resonance Imaging; D009369:Neoplasms / Q000175:diagnosis* / Q000532:radiotherapy; D049268:Positron-Emission Tomography; D011832:Radiation Injuries / Q000517:prevention & control; D011880:Radiotherapy Planning, Computer-Assisted; D020266:Radiotherapy, Conformal / Q000379:methods / Q000592:standards; D050397:Radiotherapy, Intensity-Modulated / Q000379:methods / Q000592:standards; D014057:Tomography, X-Ray Computed; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis / Q000532:radiotherapy