Ascending the learning curve--MSI testing experience of a six-laboratory consortium.
According to recently published guidelines, microsatellite instability (MSI) testing of colorectal cancers may be clinically indicated on a significant proportion of all colorectal tumors. To date, nothing has been published regarding the reproducibility of MSI testing between laboratories. We present MSI quality control activities experience of a six center multinational consortium, as laboratories developed competency with MSI testing and interpretation. The aim of this paper is to share lessons learned and to describe the final concordance rates in scoring MSI markers within this consortium.
Lindor
Noralane M
NM
Department of Medical Genetics, Mayo Clinic, Rochester, MN 55905, USA. nlindor@mayo.edu
Smalley
Regenia
R
Barker
Melissa
M
Bigler
Jeannette
J
Krumroy
Lisa M
LM
Lum-Jones
Annette
A
Plummer
Sarah J
SJ
Selander
Teresa
T
Thomas
Sushma
S
Youash
Michelle
M
Seminara
Daniela
D
Casey
Graham
G
Bapat
Bharati
B
Thibodeau
Stephen N
SN
D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000235:genetics*; D006801:Humans; D053842:Microsatellite Instability; D018895:Microsatellite Repeats / Q000235:genetics*; D011786:Quality Control; D012042:Registries