Carinatumins A-C, new alkaloids from Lycopodium carinatum inhibiting acetylcholinesterase.
Three new Lycopodium alkaloids, carinatumins A-C (1-3), have been isolated from the club moss Lycopodium carinatum. Structures and stereochemistry of 1-3 were elucidated on the basis of 2D NMR correlations. Carinatumins A (1) and B (2) exhibited a potent inhibitory activity against acetylcholinesterase.
Choo
Chee Yan
CY
Faculty of Pharmaceutical Sciences, Hoshi University, Shinagawa-ku, Tokyo 142-8501, Japan.
Hirasawa
Yusuke
Y
Karimata
Chiaki
C
Koyama
Koichiro
K
Sekiguchi
Mitsuhiro
M
Kobayashi
Jun'ichi
J
Morita
Hiroshi
H
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification; D002228:Carbenicillin / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology; D002800:Cholinesterase Inhibitors / Q000737:chemistry* / Q000302:isolation & purification*; D032502:Lycopodium / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry; D011728:Pyridones / Q000302:isolation & purification* / Q000494:pharmacology; D013237:Stereoisomerism
D000470:Alkaloids; D002800:Cholinesterase Inhibitors; D011728:Pyridones; C518511:carinatumin B; C518512:carinatumin C; C100244:carbenicillin indanyl; D002228:Carbenicillin