Role of bone morphogenetic proteins in cardiac differentiation.
Bone morphogenetic proteins (BMP) are involved in the regulation of a plethora of processes underlying cardiovascular development. This review summarizes the effects of BMP and the signaling pathways that regulate the differentiation of cardiomyocytes from mesoderm in the heart-forming region and at the distal borders of the heart tube from the second heart field. Subsequently, the role of BMPs in the formation of the ventricular chambers and septovalvulogenesis in the atrioventricular canal and outflow tract is described. Finally, the effects of BMPs in stem cell biology and cardiac regeneration are discussed.
van Wijk
Bram
B
Molecular and Experimental Cardiology Group, Department of Anatomy and Embryology, Academic Medical Center, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands.
Moorman
Antoon F M
AF
van den Hoff
Maurice J B
MJ
D000818:Animals; D019485:Bone Morphogenetic Proteins / Q000502:physiology*; D002454:Cell Differentiation / Q000502:physiology; D006321:Heart / Q000196:embryology*; D006352:Heart Ventricles; D006801:Humans; D009024:Morphogenesis / Q000502:physiology; D032383:Myocytes, Cardiac / Q000166:cytology; D015398:Signal Transduction / Q000502:physiology
D019485:Bone Morphogenetic Proteins