Extracts and sesquiterpene derivatives from the red alga Laurencia chondrioides with antibacterial activity against fish and human pathogenic bacteria.
During screening of seaweeds from different places in Europe for antimicrobial activities against human and fish pathogenic bacteria, Laurencia chondrioides was identified as a promising species. By bioassay-guided isolation, followed by structure elucidation by mass spectrometry and 1H- and 13C-NMR spectrometry, two sesquiterpenoides of the chamigrene-type from the selected red seaweed Laurencia chondrioides were identified. Both compounds inhibit the growth of some fish and human pathogenic bacteria.
Bansemir
Anne
A
Institute of Pharmacy, Department of Pharmaceutical Biology, Ernst-Moritz-Arndt University of Greifswald, Jahnstrasse 17, D-17487 Greifswald.
Just
Natalie
N
Michalik
Manfred
M
Lindequist
Ulrike
U
Lalk
Michael
M
D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects* / Q000472:pathogenicity*; D005393:Fish Diseases / Q000382:microbiology / Q000517:prevention & control; D005399:Fishes / Q000382:microbiology*; D006801:Humans; D044722:Laurencia / Q000737:chemistry* / Q000502:physiology*; D008826:Microbial Sensitivity Tests; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D012717:Sesquiterpenes