title: A novel t(2;3)(p11;q27) in a case of follicular lymphoma.
abstract: Rearrangement of the BCL6 gene is found in follicular lymphomas and in diffuse large B cell lymphomas of follicular center cell origin. The breakpoints cluster mainly in a region spanning the first noncoding exon of the gene (the major breakpoint region). A second breakpoint cluster has also been identified upstream of the first BCL6 noncoding exon (the alternative breakpoint region [ABR]). To date, eight different rearrangements involving the ABR have been reported. Here, we describe a novel rearrangement involving a t(2;3)(p11;q27) translocation that affects the ABR in an unusual combination with the IGK locus.
authors.affiliation: IFOM, FIRC Institute for Molecular Oncology Foundation, Via Adamello 16, 20139 Milan, Italy.
authors.forename: Cinzia
authors.initials: C
authors.lastname: Tapinassi
authors.forename: Carla
authors.initials: C
authors.lastname: Micucci
authors.forename: Idoya
authors.initials: I
authors.lastname: Lahortiga
authors.forename: Omar
authors.initials: O
authors.lastname: Malazzi
authors.forename: Patrizia
authors.initials: P
authors.lastname: Gasparini
authors.forename: Ana
authors.initials: A
authors.lastname: Gorosquieta
authors.forename: Maria D
authors.initials: MD
authors.lastname: Odero
authors.forename: Elena
authors.initials: E
authors.lastname: Belloni
mesh_terms: D000368:Aged; D002889:Chromosomes, Human, Pair 2 / Q000235:genetics*; D002893:Chromosomes, Human, Pair 3 / Q000235:genetics*; D015321:Gene Rearrangement; D006801:Humans; D007136:Immunoglobulins / Q000235:genetics; D008224:Lymphoma, Follicular / Q000145:classification / Q000235:genetics*; D008297:Male; D016133:Polymerase Chain Reaction; D051560:Proto-Oncogene Proteins c-bcl-6 / Q000235:genetics; D014178:Translocation, Genetic / Q000235:genetics*
chemical_list: C014609:IgK; D007136:Immunoglobulins; D051560:Proto-Oncogene Proteins c-bcl-6