X-ray single-crystal analysis of (-)-(S)-equol isolated from rat's feces.
The biological effects of soy isoflavones have attracted considerable interest in recent years, leading to numerous studies on dietary intake and epidemiology. (-)-(S)-equol (3) is a metabolite produced in vivo from the isoflavone daidzein, a kind of soy phytoestrogen, by the action of gut microflora. It has higher biological activity than its precursor. Here, we wish to report the isolation and first X-ray crystal structure of 3 from the feces of rats fed a soy-isoflavone-containing diet.
Liang
Gaolin
G
Department of Chemistry of Natural Drugs, School of Pharmacy, Fudan University, Shanghai 200032, PR China. lianggl72@shmu.edu.cn
Zhang
Tong
T
Wang
Jingmei
J
Chen
Buyun
B
Cheng
Kejun
K
Hu
Changqi
C
D000818:Animals; D018360:Crystallography, X-Ray; D060754:Equol; D005243:Feces / Q000737:chemistry*; D005260:Female; D007529:Isoflavones / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D051381:Rats; D017207:Rats, Sprague-Dawley
C007610:4',7-dihydroxy-3,4-dihydroisoflavone; D007529:Isoflavones; D060754:Equol