A view to a kill: structure of the RNA exosome.
The exosome is a 3' to 5' exoribonuclease central to many cellular processes, including mRNA decay. now present the biochemical reconstitution and crystal structure of the eukaryotic exosome. This remarkable achievement provides key insights into the composition and assembly of the human and yeast exosomes, revealing functions of individual subunits.
Shen
Vincent
V
Rutgers University, Department of Cell Biology and Neuroscience, 604 Allison Road, Piscataway, NJ 08854, USA.
Kiledjian
Megerditch
M
D001105:Archaea / Q000737:chemistry; D018360:Crystallography, X-Ray; D005095:Exoribonucleases / Q000737:chemistry*; D006801:Humans; D008958:Models, Molecular; D046912:Multiprotein Complexes; D011487:Protein Conformation; D020871:RNA Stability; D015003:Yeasts / Q000737:chemistry
D046912:Multiprotein Complexes; D005095:Exoribonucleases