title: Identifying neuropeptide and protein hormone receptors in Drosophila melanogaster by exploiting genomic data.
abstract: Most neuropeptide and protein hormone receptors belong to the large superfamily of G-protein-coupled receptors (GPCRs). These cell membrane proteins steer many important processes such as development, reproduction, homeostasis and behaviour when activated by their corresponding ligands. The first insect genome, that of the fruitfly Drosophila melanogaster, was sequenced in 2000, and about 200 GPCRs have been annnotated in this model insect. About 50 of these receptors were predicted to have neuropeptides or protein hormones as their ligands. Since 2000, the cDNAs of most of these candidate receptors have been cloned and for many receptors the endogenous ligand has been identified. In this review, we will give an update about the current knowledge of all Drosophila neuropeptide and protein hormone receptors, and discuss their phylogenetic relationships.
authors.affiliation: Department of Cell Biology and Comparative Zoology, Universitetsparken 15, DK-2100 Copenhagen, Denmark. fhauser@bi.ku.dk
authors.forename: Frank
authors.initials: F
authors.lastname: Hauser
authors.forename: Michael
authors.initials: M
authors.lastname: Williamson
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Cazzamali
authors.forename: Cornelis J P
authors.initials: CJ
authors.lastname: Grimmelikhuijzen
mesh_terms: D000818:Animals; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism; D004331:Drosophila melanogaster / Q000235:genetics* / Q000378:metabolism; D049750:Genome, Insect / Q000235:genetics*; D010802:Phylogeny; D043562:Receptors, G-Protein-Coupled / Q000235:genetics* / Q000378:metabolism; D018010:Receptors, Invertebrate Peptide / Q000235:genetics / Q000378:metabolism; D018013:Receptors, Neuropeptide / Q000235:genetics / Q000378:metabolism; D011987:Receptors, Steroid / Q000235:genetics / Q000378:metabolism
chemical_list: D029721:Drosophila Proteins; D043562:Receptors, G-Protein-Coupled; D018010:Receptors, Invertebrate Peptide; D018013:Receptors, Neuropeptide; D011987:Receptors, Steroid; C055469:ecdysone receptor