title: Profile of systemic sclerosis in a tertiary care center in North India.
abstract: OBJECTIVE
  To study the clinical and immunological profile in patients of systemic sclerosis from North India and compare it with other ethnic groups.
  
  
  METHODS
  Patients presenting to us between the years 2001 and 2004 and fulfilling the American Rheumatism Association (ARA) criteria for systemic sclerosis were included. There were 84 females and 16 males with the mean age of 32.5 +/-11.62 years and a mean duration of 6.49 +/- 4.34 years. All patients were admitted to the dermatology ward for detailed history and examination including Rodnan score. Investigations including hemogram, hepatic and renal functions, serum electrolytes, urine for albumin, sugar, microscopy and 24h urinary protein estimation, antinuclear antibody, chest X-ray, barium swallow, pulmonary function test, electrocardiogram and skin biopsy were done.
  
  
  RESULTS
  The most common presenting symptoms were skin binding-down (98.5%), Raynaud's phenomenon 92.9%, pigmentary changes 91%, contracture of fingers 64.6%, fingertip ulcer 58.6%, restriction of mouth opening 55.5%, dyspnea 51.1%, joint complaints 36.7% and dysphagia in 35.2%. The mean Rodnan score was 25.81 +/- 10.04 and the mean mouth opening was 24.6 +/- 19.01 mm. The laboratory abnormalities included raised ESR in 87.8%, ANA positive in 89.1%, proteinuria in 6.0%, abnormal chest X-ray in 65.3%, abnormal barium swallow in 70.2% and reduced pulmonary function test in 85.8%.
  
  
  CONCLUSIONS
  The clinical and immunological profile of systemic sclerosis in North India is similar to that of other ethnic groups except that pigmentary changes are commoner and renal involvement is relatively uncommon.
authors.affiliation: Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi, India. aiimsvks@yahoo.com
authors.forename: Vinod K
authors.initials: VK
authors.lastname: Sharma
authors.forename: Tejasvi
authors.initials: T
authors.lastname: Trilokraj
authors.forename: Binod K
authors.initials: BK
authors.lastname: Khaitan
authors.forename: Sumanth M
authors.initials: SM
authors.lastname: Krishna
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000974:Antibodies, Antinuclear / Q000378:metabolism; D044466:Asian People; D002648:Child; D003286:Contracture / Q000209:etiology; D004064:Digestive System / Q000503:physiopathology; D005006:Ethnicity; D005260:Female; D006225:Hand / Q000000981:diagnostic imaging; D006801:Humans; D007194:India; D008297:Male; D008875:Middle Aged; D009055:Mouth / Q000503:physiopathology; D010024:Osteoporosis / Q000150:complications; D010859:Pigmentation Disorders / Q000209:etiology; D013902:Radiography, Thoracic; D012595:Scleroderma, Systemic / Q000150:complications* / Q000175:diagnosis / Q000208:ethnology / Q000503:physiopathology*; D012867:Skin / Q000473:pathology; D014018:Tissue Distribution
chemical_list: D000974:Antibodies, Antinuclear