title: CD8 T-cell subsets and viral load in the cerebrospinal fluid of therapy-naive HIV-infected individuals.
abstract: Central nervous system involvement is common in HIV infection. We determined the relationship between T-cell subsets and viral load in the cerebrospinal fluid (CSF) of therapy-naive, asymptomatic HIV-infected individuals. A shift from naive to effector-memory CD8 T cells was observed in the CSF of HIV-infected individuals compared with controls. The HIV load strongly correlated with CD8 T cells in CSF. Effector-memory CD8 T cells were positively and effector CD8 T cells were negatively associated with viral replication in CSF.
authors.affiliation: Department of Neurology, Germany.
authors.forename: Gloria
authors.initials: G
authors.lastname: von Geldern
authors.forename: Sabine
authors.initials: S
authors.lastname: Cepok
authors.forename: Thorsten
authors.initials: T
authors.lastname: Nolting
authors.forename: Yihua
authors.initials: Y
authors.lastname: Du
authors.forename: Verena
authors.initials: V
authors.lastname: Grummel
authors.forename: Ortwin
authors.initials: O
authors.lastname: Adams
authors.forename: Hans-Peter
authors.initials: HP
authors.lastname: Hartung
authors.forename: Gabriele
authors.initials: G
authors.lastname: Arendt
authors.forename: Bernhard
authors.initials: B
authors.lastname: Hemmer
mesh_terms: D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D015658:HIV Infections / Q000134:cerebrospinal fluid / Q000276:immunology* / Q000821:virology; D015497:HIV-1 / Q000302:isolation & purification*; D006801:Humans; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D019562:Viral Load