Synthesis and antiviral activity of C-fluoro-branched cyclopropyl nucleosides.
A series of novel fluorocyclopropyl nucleosides were synthesized starting from acetol using the Simmons-Smith reaction as a key reaction. All the nucleosides synthesized were assayed against several viruses. Among the compounds synthesized, the uracil analogue 22 showed moderate anti-HCMV activity (10.61 microg/mL, in AD-169).
Kim
Aihong
A
College of Pharmacy, Chosun University, Kwangju 501-759, Republic of Korea.
Hong
Joon Hee
JH
D000998:Antiviral Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D002478:Cells, Cultured; D003521:Cyclopropanes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D006678:HIV / Q000187:drug effects*; D018259:Herpesvirus 1, Human / Q000187:drug effects*; D018258:Herpesvirus 2, Human / Q000187:drug effects*; D006801:Humans; D006845:Hydrocarbons, Fluorinated / Q000737:chemistry; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009705:Nucleosides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
D000998:Antiviral Agents; D003521:Cyclopropanes; D006845:Hydrocarbons, Fluorinated; D009705:Nucleosides