Poor prognosis of intraoperative rupture of mature cystic teratoma with malignant transformation.
OBJECTIVE
To present the phenomenon of the postoperative rapid progression of mature cystic teratoma (MCT) with malignant transformation (MT) when intraoperative spillage occurs during operation.


METHODS
Two patients with MCT were treated, one with total hysterectomy plus bilateral salpingo-oophorectomy in an exploratory laparotomy, and the other with cystectomy with laparoscopy, respectively. Tumor spillage occurred during both operations. The postoperative pathology showed MCT with MT (squamous cell carcinoma type). Both patients were referred to our hospital and underwent treatment (3 months and 8 days, respectively, after the initial operation). At the secondary laparotomy for staging surgery, tumor dissemination was observed in both patients.


CONCLUSIONS
Whether or not tumor dissemination is correlated with tumor rupture during operation, we emphasize that any patient with a preoperative diagnosis of MCT should have it removed intact to avoid the possibly catastrophic event of tumor dissemination.
Wen
Kuo-Chang
KC
Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, and Institute of Emergency and Critical Care Medicine, National Yang-Ming University, Taipei, Taiwan.
Hu
Wei-Ming
WM
Twu
Nae-Fang
NF
Chen
Pwu
P
Wang
Peng-Hui
PH
D000038:Abscess / Q000601:surgery; D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D002471:Cell Transformation, Neoplastic; D017024:Chemotherapy, Adjuvant; D018450:Disease Progression; D005184:Fallopian Tube Diseases / Q000601:surgery; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007431:Intraoperative Complications / Q000473:pathology*; D008875:Middle Aged; D010049:Ovarian Diseases / Q000601:surgery; D010051:Ovarian Neoplasms / Q000473:pathology* / Q000601:surgery; D011379:Prognosis; D013724:Teratoma / Q000473:pathology* / Q000601:surgery