[Changes in the calcitonin content after inhalation injury in dogs].
OBJECTIVE
To investigate the changes in the serum content of immunoreactive calcitonin (iCT) after burns or inhalation injury, and to explore its diagnostic significance.


METHODS
Twenty-four dogs were randomized into 4 groups, i. e. A (n = 6, with moderate degree inhalation injury) , B ( n = 6, with severe inhalation injury), C (n = 6, with most severe inhalation injury) and D (n = 6, with severe burns) groups. The serum content of iCT and blood gas analysis before and after injury were determined at different time points. The degree of inhalation injury was determined with fibrobronchoscopic examination at 6 post-inhalation injury hour (PIH).


RESULTS
(1) Fiber bronchoscopic examination showed that the degree of inhalation injury in each group was coincident with the anticipation. (2) The serum content of iCT in each group at 1 PIH was obviously higher than that before injury, and it was evidently higher in A, B and C groups than that in D group at 4 PIH. The peak value of iCT in group A at 24 PIH was (453+/-224) ng/L, and it increased gradually in B and C groups at 48 PIH. The serum content of iCT increased continually from 2 PIH on, and it reached (125+/-41) ng/L at 48 PIH. (3) Compared with PaO2 value before injury (109+/-8) mmHg, there was no obvious difference of the PaO, in A and D groups. PaO2 value in B and C group began to descend continually at 8 PIH (65+/-6) mmHg, and that in C group began to descend at 4 PIH (71+/-9) mmHg. PaCO2 value in C group began to increase at 24 PIH(52+/-11) mmHg when compared with that before injury(38+/-5 ) mmHg.


CONCLUSIONS
The changes in the serum level of iCT within 8 PIH occurred much earlier than PaO2 and PaCO2, thus it has the same diagnostic significance as fibers bronchoscopic examination.
Fan
Kun-wu
KW
Department of Burns and Plastic Surgery, Shenzhen Second Hospital, PR China.
Li
Guo-hui
GH
Zhu
Zhi-xiang
ZX
Deng
Zhi-yun
ZY
Li
Yue
Y
Zhang
Qing
Q
Wen
Gui-lan
GL
Wang
Nian-yun
NY
Yan
Ji
J
Guo
Guang-hua
GH
D000818:Animals; D001784:Blood Gas Analysis; D002059:Burns, Inhalation / Q000097:blood* / Q000503:physiopathology; D002116:Calcitonin / Q000097:blood*; D004195:Disease Models, Animal; D004285:Dogs
D002116:Calcitonin