Two new taxanes from the needles and branches bark of Taxus cuspidata.
Two new taxanes were isolated from the MeOH extract of the needles and branches bark of the Japanese yew, Taxus cuspidata. The structures were established as (2alpha,5alpha,7beta,9alpha,10beta,13alpha)-5,10,13,20-tetraacetoxytax-11-ene-2,7,9-triol (1) and (2alpha,5alpha,9alpha,10beta)-2,9,10-triacetoxy-5-[(beta-D-glucopyranosyl)oxy]-3,11-cyclotax-11-en-13-one (2) on the basis of in-depth 1D- and 2D-NMR analyses. Compound 2 is the first example of a transannular taxane glycoside isolated from a natural source.
Cao
Cong-Mei
CM
Laboratory of Medicinal Natural Product Chemistry, School of Pharmaceutical Sciences, Hebei Medicinal University, 361 Zhongshan East Road, 050017, Shijiazhuang, Hebei Province, P.R. China.
Zhang
Man-Li
ML
Wang
Yu-Fang
YF
Shi
Qing-Wen
QW
Yamada
Teiko
T
Kiyota
Hiromasa
H
D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D024301:Plant Bark / Q000737:chemistry; D018515:Plant Leaves / Q000737:chemistry; D043823:Taxoids / Q000737:chemistry / Q000302:isolation & purification*; D020946:Taxus / Q000737:chemistry*
C517475:(2alpha,5alpha,7beta,9alpha,10beta,13alpha)-5,10,13,20-tetraacetoxytax-11-ene-2,7,9-triol; C517474:(2alpha,5alpha,9alpha,10beta)-2,9,10-triacetoxy-5-((beta-D-glucopyranosyl)oxy)-3,11-cyclotax-11-en-13-one; D043823:Taxoids