title: Sequestosome 1/p62--more than just a scaffold.
abstract: The interaction of proteins with ubiquitin receptors is key to solving the mystery that surrounds the functional role ubiquitin chains play in directing traffic. The specificity of these interactions is largely mediated by UbL/UBA domains. Sequestosome 1/p62 is a protein that is gaining attention as it is intimately involved in cell signaling, receptor internalization, and protein turnover. Herein we review recent advances in the field.
authors.affiliation: Department of Biological Sciences, Program in Cellular and Molecular Biosciences, 331 Funchess Hall, Auburn University, Auburn, AL 36849, United States.
authors.forename: M Lamar
authors.initials: ML
authors.lastname: Seibenhener
authors.forename: Thangiah
authors.initials: T
authors.lastname: Geetha
authors.forename: Marie W
authors.initials: MW
authors.lastname: Wooten
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D006801:Humans; D017434:Protein Structure, Tertiary; D011506:Proteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D000071456:Sequestosome-1 Protein; D025801:Ubiquitin / Q000378:metabolism
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D011506:Proteins; C099718:SQSTM1 protein, human; D000071456:Sequestosome-1 Protein; D025801:Ubiquitin