title: [Prostate small cell carcinoma: report of two cases that differed in treatment responsiveness].
abstract: Case 1 : A 76-year-old man with a chief complaint of dysuria had an elevated prostate specific antigen (PSA) level of 24.9. He underwent a transperineal needle biopsy of the prostate, and the histopathological diagnosis was prostatic small cell carcinoma. The cancer was clinically diagnosed as T3bN1M1 with multiple lung metastases. He started receiving hormonal therapy. After three months of hormonal therapy, the multiple lung metastases disappeared. Thereafter, the serum PSA level and the tumor volume increased and he died 12 months from the start of therapy. Case 2: A 79-year-old man was referred to our hospital with a chief complaint of dysuria. The serum level of PSA was elevated to 10.4. Transperineal prostate biopsy revealed prostatic small cell carcinoma. The cancer was clinically diagnosed as T3bN1M1, and hormonal therapy was started. Subsequently, although his serum PSA level declined, his condition worsened rapidly and he died five months after the start of therapy.
authors.affiliation: The Department of Urology, Osaka Rosai Hospital.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Yoshida
authors.forename: Kensaku
authors.initials: K
authors.lastname: Nishimura
authors.forename: Motohide
authors.initials: M
authors.lastname: Uemura
authors.forename: Katsuhiro
authors.initials: K
authors.lastname: Nakagawa
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Harada
authors.forename: Nobuhumi
authors.initials: N
authors.lastname: Kanno
authors.forename: Susumu
authors.initials: S
authors.lastname: Miyoshi
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Kawano
mesh_terms: D000368:Aged; D000726:Androgen Antagonists / Q000627:therapeutic use*; D000813:Anilides / Q000627:therapeutic use*; D018288:Carcinoma, Small Cell / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D008297:Male; D009570:Nitriles; D011471:Prostatic Neoplasms / Q000188:drug therapy* / Q000473:pathology; D014105:Tosyl Compounds
chemical_list: D000726:Androgen Antagonists; D000813:Anilides; D009570:Nitriles; D014105:Tosyl Compounds; C053541:bicalutamide