13C-CPMAS and 1H-NMR study of the inclusion complexes of beta-cyclodextrin with carvacrol, thymol, and eugenol prepared in supercritical carbon dioxide.
Beta-cyclodextrin (beta-CD) inclusion complexes with carvacrol (1), thymol (2), and eugenol (3) (components of essential oils of vegetable origin) were prepared by the supercritical CO2 technique, and their structural characterization was achieved by means of 1H-NMR in aqueous solution and 13C-CPMAS NMR in the solid state. Evidence of the formation of the inclusion complexes for all the examined systems was obtained by 1H-NMR in solution, while 2D-ROESY-NMR experiments were used to investigate the geometry of inclusion. In addition, the dynamics of these inclusion complexes in the kHz timescale was investigated by analysis of the 1H and 13C spin-lattice relaxation times in the rotating frame.
Locci
Emanuela
E
Dipartimento di Scienze Chimiche, Università di Cagliari, Cittadella Universitaria di Monserrato, I-09042 Monserrato CA.
Lai
Simona
S
Piras
Alessandra
A
Marongiu
Bruno
B
Lai
Adolfo
A
D002245:Carbon Dioxide / Q000032:analysis / Q000737:chemistry; D002247:Carbon Isotopes; D025924:Chromatography, Supercritical Fluid / Q000379:methods*; D000081007:Cymenes; D004578:Electron Spin Resonance Spectroscopy / Q000379:methods; D005054:Eugenol / Q000032:analysis* / Q000138:chemical synthesis; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D039821:Monoterpenes / Q000032:analysis* / Q000138:chemical synthesis; D011522:Protons; D013943:Thymol / Q000032:analysis* / Q000138:chemical synthesis; D047392:beta-Cyclodextrins / Q000032:analysis* / Q000138:chemical synthesis
D002247:Carbon Isotopes; D000081007:Cymenes; D039821:Monoterpenes; D011522:Protons; D047392:beta-Cyclodextrins; D002245:Carbon Dioxide; D013943:Thymol; D005054:Eugenol; C073316:carvacrol; C031215:betadex