title: [Active constituents from Aloe arborescens as BACE inhibitors].
abstract: OBJECTIVE
  To seek for new components as BACE inhibitors from Aloe arborescens.
  
  
  METHODS
  The chemical constituents were isolated by chromatographic methods and their structures were elucidated on the basis of spectral analysis.
  
  
  RESULTS
  Eight compounds were isolated and their structures identified as 6'-O-isobutyryl aloenin A (1), aloenin A (2), aloe-emodin (3), (E)-2-acetonyl-8-(2'-O-feruloxyl)-beta-D-glucopyranosyl-7-methoxy-5-methyl-chromone (4), 7-O-methylaloeresin A (5), babarloin A (6), elgonica-dimer A (7), and elgonica-dimer B (8), separately.
  
  
  CONCLUSIONS
  Compound 1 is a new compound, and compound 4 was isolated from A. arborescens for the first time. Pharmacological tests indicated that 2, 4, 5 and 6 have moderate inhibitory active on BACE.
authors.affiliation: Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Gao
authors.forename: Chun-Suo
authors.initials: CS
authors.lastname: Yao
authors.forename: Jin-Yun
authors.initials: JY
authors.lastname: Zhou
authors.forename: Ruo-Yun
authors.initials: RY
authors.lastname: Chen
authors.forename: Wei-Shuo
authors.initials: WS
authors.lastname: Fang
mesh_terms: D000504:Aloe / Q000737:chemistry*; D053829:Amyloid Precursor Protein Secretases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D000880:Anthraquinones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D016282:Aspartic Acid Endopeptidases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D002867:Chromones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D008968:Molecular Conformation; D015394:Molecular Structure; D035261:Plant Components, Aerial / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry; D011753:Pyrones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: C526373:2-acetonyl-8-(2'-O-feruloxyl)glucopyranosyl-7-methoxy-5-methylchromone; C526372:6'-O-isobutyryl aloenin A; D000880:Anthraquinones; D002867:Chromones; D004791:Enzyme Inhibitors; D005960:Glucosides; D010936:Plant Extracts; D011753:Pyrones; C459214:elgonica dimer A; D053829:Amyloid Precursor Protein Secretases; D016282:Aspartic Acid Endopeptidases; C509280:BACE1 protein, human