[Prevalence of diabetes-related autoantibodies in celiac disease].
OBJECTIVE
of this study is to investigate the prevalence of diabetes-related autoantibodies in a group of children with celiac disease and to compare it with a control group.


METHODS
We recruited 31 celiac children at diagnosis (on gluten containing diet) and 31 age and sex matched healthy children. Anti-islet cell antibodies (ICA) were detected by indirect immunofluorescence on monkey pancreas. Anti-glutamate decarboxylase (anti-GAD) and anti-tyrosine phosphatase (anti-IA2) antibodies were assessed by a radio-immuno- precipitation method.


RESULTS
Three out of 31 celiac patients (9.7%) had one or more diabetes-related autoantibodies. ICA, anti-GAD and anti-IA2 were found in respectively 3.2%; 3.2% and 9.7% of patients. Only one control (3.2%) had anti-GAD. There was no statistically significant difference between the 2 groups.


CONCLUSIONS
The risk to develop diabetes seems to be the same in celiac patients and in healthy subjects thus screening of diabetes-related autoantibodies is not justified in celiac patients.
Laadhar
L
L
Laboratoire d'Immunologie, hôpital La Rabta, 1007 Tunis, Tunisia. lilia_laadhar@yahoo.com
Ben Hariz
M
M
Zitouni
M
M
Sellami-Kallel
M
M
Toumi
A
A
Mehrezi
A
A
Makni
S
S
D001323:Autoantibodies / Q000097:blood*; D002446:Celiac Disease / Q000097:blood / Q000276:immunology*; D002648:Child; D003920:Diabetes Mellitus / Q000097:blood / Q000276:immunology*; D005260:Female; D005968:Glutamate Decarboxylase / Q000276:immunology*; D006801:Humans; D007515:Islets of Langerhans / Q000276:immunology; D017027:Protein Tyrosine Phosphatases / Q000276:immunology; D012016:Reference Values
D001323:Autoantibodies; C024211:islet cell antibody; D017027:Protein Tyrosine Phosphatases; D005968:Glutamate Decarboxylase