title: Autoimmune regulator (AIRE) gene is expressed in human activated CD4+ T-cells and regulated by mitogen-activated protein kinase pathway.
abstract: The autoimmune regulator (AIRE) gene is a gene responsible for autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. Here we show that AIRE is expressed in human peripheral CD4-positive T-cells, and most highly in antigen-and interleukin 2-stimulated T (IL-2T) cells. Mitogen-activated protein kinases (MAPKs), including MAPK kinase (MEK) 1/2 and p38 MAPK, were phosphorylated in IL-2T cells and the expression of the AIRE gene was inhibited by a specific p38 MAPK inhibitor (SB203580), thereby indicating that AIRE gene expression is controlled by the MAPK pathway in IL-2T cells. These data suggested the possible significance of the AIRE gene in the peripheral immune system.
authors.affiliation: Department of Medical Science and Technology, School of Medicine, Kyushu University, Fukuoka, Japan. nagafuchi@shs.kyushu-u.ac.jp
authors.forename: Seiho
authors.initials: S
authors.lastname: Nagafuchi
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Katsuta
authors.forename: Rimiko
authors.initials: R
authors.lastname: Koyanagi-Katsuta
authors.forename: Satoshi
authors.initials: S
authors.lastname: Yamasaki
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Inoue
authors.forename: Kazuya
authors.initials: K
authors.lastname: Shimoda
authors.forename: Yukari
authors.initials: Y
authors.lastname: Ikeda
authors.forename: Mieko
authors.initials: M
authors.lastname: Shindo
authors.forename: Eiko
authors.initials: E
authors.lastname: Yoshida
authors.forename: Tomohito
authors.initials: T
authors.lastname: Matsuo
authors.forename: Yuju
authors.initials: Y
authors.lastname: Ohno
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Kogawa
authors.forename: Keizo
authors.initials: K
authors.lastname: Anzai
authors.forename: Hironori
authors.initials: H
authors.lastname: Kurisaki
authors.forename: Jun
authors.initials: J
authors.lastname: Kudoh
authors.forename: Mine
authors.initials: M
authors.lastname: Harada
authors.forename: Nobuyoshi
authors.initials: N
authors.lastname: Shimizu
mesh_terms: D015496:CD4-Positive T-Lymphocytes / Q000378:metabolism*; D005809:Genes, Regulator; D006801:Humans; D020935:MAP Kinase Signaling System / Q000502:physiology; D020928:Mitogen-Activated Protein Kinases / Q000037:antagonists & inhibitors / Q000378:metabolism / Q000502:physiology*; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*; D000096927:AIRE Protein
chemical_list: D020928:Mitogen-Activated Protein Kinases; D014157:Transcription Factors; D000096927:AIRE Protein