Update on gingival overgrowth by cyclosporine A in renal transplants.
Severe gingival overgrowth is one of the most frequent side effects in renal transplant patients associated with assumption of cyclosporine A. Several associations with age, sex, dosage, duration of therapy or interval since transplantation have been hypothesized. The introduction of alternative immunosuppressant drugs have been suggested to permit better long-term transplant outcomes and a decrease in incidence of gingival overgrowth. The aim of the present paper is to summarize current knowledge regarding aetiology, pathogenesis and management of gingival overgrowth induced by Cyclosporine A.
Ciavarella
Domenico
D
Department of Surgical Sciences, University of Foggia, Foggia, Italy.
Guiglia
Rosario
R
Campisi
Giuseppina
G
Di Cosola
Michele
M
Di Liberto
Chiara
C
Sabatucci
Antonio
A
Escudero
Nayra
N
Bascones
Antonio
A
Lo Muzio
Lorenzo
L
D016572:Cyclosporine / Q000009:adverse effects*; D019214:Gingival Overgrowth / Q000139:chemically induced*; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D016030:Kidney Transplantation; D011183:Postoperative Complications / Q000139:chemically induced*
D007166:Immunosuppressive Agents; D016572:Cyclosporine