title: Primary synovial sarcoma in fallopian tube: case report and literature review.
abstract: Synovial sarcoma, a malignant mesenchymal neoplasm, occurs mostly near the joints of the extremities and occasionally outside the joint such as lung. We report a case of soft tissue sarcoma arising in the fallopian tube origin that showed characteristic pathological appearance of biphasic synovial sarcoma. Molecular analysis detected a fusion gene transcript of synovial sarcoma translocation (SYT) gene from chromosome 18 and synovial sarcoma X chromosome breakpoint 1 (SSX1) gene, which is believed to pathognomonic for synovial sarcoma of joint origin. Recurrent abdominal tumor, observed at 12 month after the initial surgery and following chemotherapy using doxorubicin, cisplatin and ifosfamide, partially responded to chemotherapy using paclitaxel and carboplatin and, then, optimal surgery was performed. This is the first report of a synovial sarcoma arising in the fallopian tube.
authors.affiliation: Department of Reproductive Medicine, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan. makira-cib@umin.ac.jp
authors.forename: Akira
authors.initials: A
authors.lastname: Mitsuhashi
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Nagai
authors.forename: Kiyomi
authors.initials: K
authors.lastname: Suzuka
authors.forename: Koji
authors.initials: K
authors.lastname: Yamazawa
authors.forename: Takayuki
authors.initials: T
authors.lastname: Nojima
authors.forename: Takashi
authors.initials: T
authors.lastname: Nikaido
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ishikura
authors.forename: Hideo
authors.initials: H
authors.lastname: Matsui
authors.forename: Makio
authors.initials: M
authors.lastname: Shozu
mesh_terms: D000328:Adult; D001483:Base Sequence; D005185:Fallopian Tube Neoplasms / Q000235:genetics / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D015514:Oncogene Proteins, Fusion / Q000235:genetics; D013584:Sarcoma, Synovial / Q000235:genetics / Q000473:pathology* / Q000601:surgery
chemical_list: D015514:Oncogene Proteins, Fusion; C116512:SYT-SSX fusion protein