title: [A patient with long-term, unrecognized leishmaniasis].
abstract: A man from Surinam presented at the Department of Internal Medicine with a perforated septum and progressive collapse of the nose. This condition had existed for 22 years, though earlier analysis had not revealed the cause. Microscopic analysis showed a granulomatous inflammatory reaction, with cultures revealing of Leishmania. The diagnosis was mucocutaneous leishmaniasis and PCR indicated Leishmania braziliensis complex. The patient was treated for mucocutaneous leishmaniasis by a 28-day course of intravenous sodium-stibogluconate therapy. Initially, treatment was stopped briefly due to neurotoxicity, but was recommenced and successfully completed. After treatment the infection parameters returned to normal and the patient was referred for reconstructive nasal surgery. Due to a low parasitic load mucocutaneous leishmaniasis can be difficult to detect, especially in chronic cases. However, the use of molecular techniques has improved both the sensitivity and specificity of detection. The ability to distinguish between different species and sub-species is of prognostic and therapeutic relevance.
authors.affiliation: Erasmus MC, Rotterdam.
authors.forename: N M
authors.initials: NM
authors.lastname: Rabelink
authors.forename: J E M
authors.initials: JE
authors.lastname: de Steenwinkel
authors.forename: P
authors.initials: P
authors.lastname: van Biezen
authors.forename: P L A
authors.initials: PL
authors.lastname: van Daele
authors.forename: I C
authors.initials: IC
authors.lastname: Gyssens
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000627:therapeutic use*; D016054:DNA, Protozoan / Q000032:analysis*; D003937:Diagnosis, Differential; D006801:Humans; D007892:Leishmania braziliensis / Q000235:genetics / Q000302:isolation & purification / Q000472:pathogenicity*; D007897:Leishmaniasis, Mucocutaneous / Q000175:diagnosis* / Q000188:drug therapy / Q000601:surgery; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction / Q000379:methods; D012680:Sensitivity and Specificity; D016896:Treatment Outcome
chemical_list: D000981:Antiprotozoal Agents; D016054:DNA, Protozoan