title: TRPM channels, calcium and redox sensors during innate immune responses.
abstract: Melastatin-related TRPM ion channels have emerged as novel therapeutic targets due to their potential ability to modulate the function and fate of immune cells during inflammation, innate, and adaptive immunity. Four family members, TRPM1, TRPM2, TRPM4 and TRPM7 have a strong presence in the immune system. TRPM channels regulate ion-homeostasis by sensing cellular redox status and cytoplasmic calcium levels. TRPM2 for example, is highly expressed in phagocytes. This channel is activated by intracellular ADP-ribose upon exposure to oxidative stress and induces cell death. Here we will review the functional links between TRPM-mediated ion conductance, chemotaxis, apoptosis, and innate immunity.
authors.affiliation: Columbus Children's Research Institute, Center for Microbial Pathogenesis, The Ohio State University, Columbus, OH 43205, USA.
authors.forename: Pam
authors.initials: P
authors.lastname: Massullo
authors.forename: Adriana
authors.initials: A
authors.lastname: Sumoza-Toledo
authors.forename: Harivadan
authors.initials: H
authors.lastname: Bhagat
authors.forename: Santiago
authors.initials: S
authors.lastname: Partida-Sánchez
mesh_terms: D000818:Animals; D002118:Calcium / Q000502:physiology*; D006801:Humans; D007113:Immunity, Innate; D010084:Oxidation-Reduction; D050053:TRPM Cation Channels / Q000502:physiology*
chemical_list: D050053:TRPM Cation Channels; D002118:Calcium