title: [Changes in the pancreas structure after exposure of the body to gravitational overloads].
abstract: The aim of this study was to determine the changes in the pancreas structure after acute and chronic exposure of organism to gravitational overloads (GO). The experiments were conducted in 36 outbred albino male rats, 12 rats formed the control group. GO effect was modeled using the centrifuge; the value of the overload thus created amounted to 4,0-6,0 gravitational units. Pancreas structure was studied using histological, electron microscopic and morphometric methods. It was found that after acute exposure to GO, mainly the reactive changes were demonstrated all the pancreatic structures studied: acinocytes, endocrinocytes, blood vessels and nervous apparatus. Chronic exposure to GO resulted in both reactive modifications, similar to those described after an acute exposure, and various compensatory-adaptive and destructive changes.
authors.forename: P S
authors.initials: PS
authors.lastname: Pashchenko
authors.forename: I V
authors.initials: IV
authors.lastname: Zakharova
mesh_terms: D000818:Animals; D018471:Hypergravity / Q000009:adverse effects*; D008297:Male; D046529:Microscopy, Electron, Transmission; D009186:Myelin Sheath / Q000648:ultrastructure*; D010179:Pancreas / Q000098:blood supply / Q000473:pathology* / Q000648:ultrastructure; D010183:Pancreatic Ducts / Q000098:blood supply / Q000473:pathology; D051381:Rats