title: Phenylephrine and pilocarpine eye drop test for dementia with Lewy bodies and Alzheimer's disease.
abstract: Pupillary response test using dilute phenylephrine, a sympathetic agonist, and dilute pilocarpine, a cholinergic agonist, were performed in 24 patients with dementia with Lewy bodies (DLB), 40 patients with Alzheimer's disease (AD), and 23 normal elderly subjects. The mydriatic response to 0.5% phenylephrine was significantly greater in the DLB group than in the AD and control groups. The mydriatic change correlated inversely with the reduction in cardiac 123I-metaiodobenzylguanidine uptake. In contrast, miotic response to 0.0625% pilocarpine was significantly greater in the DLB and AD groups than in the control group. The pupil assay using combined phenylephrine and pilocarpine eye drop test may be useful in the detection of patients with DLB and AD and in distinguishing between them.
authors.affiliation: Department of Geriatric Medicine, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo 160-0023, Japan. h-hanyu@tokyo-med.ac.jp
authors.forename: Haruo
authors.initials: H
authors.lastname: Hanyu
authors.forename: Kentaro
authors.initials: K
authors.lastname: Hirao
authors.forename: Soichiro
authors.initials: S
authors.lastname: Shimizu
authors.forename: Hidekazu
authors.initials: H
authors.lastname: Kanetaka
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Sakurai
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Iwamoto
mesh_terms: D019797:3-Iodobenzylguanidine; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000175:diagnosis* / Q000503:physiopathology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes; D007498:Iris / Q000187:drug effects / Q000294:innervation / Q000503:physiopathology; D020961:Lewy Body Disease / Q000175:diagnosis* / Q000503:physiopathology; D008297:Male; D015877:Miosis / Q000139:chemically induced* / Q000209:etiology / Q000503:physiopathology; D008916:Miotics; D015878:Mydriasis / Q000139:chemically induced* / Q000209:etiology / Q000503:physiopathology; D009184:Mydriatics; D009883:Ophthalmic Solutions; D010656:Phenylephrine; D010862:Pilocarpine; D011237:Predictive Value of Tests; D011680:Pupil / Q000187:drug effects / Q000502:physiology
chemical_list: D007457:Iodine Radioisotopes; D008916:Miotics; D009184:Mydriatics; D009883:Ophthalmic Solutions; D010862:Pilocarpine; D010656:Phenylephrine; D019797:3-Iodobenzylguanidine