The blu Blur: mutation of a vesicular glutamate transporter reduces the resolution of zebrafish vision.
Vesicular transporters mediate the packaging of neurotransmitters into synaptic vesicles and can therefore control the amount of neurotransmitter released into the synaptic cleft. In this issue of Neuron, Smear et al. demonstrate that mutation of a vesicular glutamate transporter (Vglut) found in the retinal ganglion cells (RGCs) of zebrafish alters both the synaptic transmission and connectivity between RGCs and their targets, limiting the transfer of visually evoked activity from RGCs and degrading behaviors that depend on high-acuity vision.
Demas
Jay
J
Cold Spring Harbor Lab, Beckman Building, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA.
Cline
Hollis T
HT
D000818:Animals; D018698:Glutamic Acid / Q000378:metabolism; D009154:Mutation / Q000235:genetics*; D009434:Neural Pathways / Q000166:cytology / Q000378:metabolism / Q000503:physiopathology; D012165:Retinal Ganglion Cells / Q000378:metabolism* / Q000648:ultrastructure; D009435:Synaptic Transmission / Q000235:genetics*; D050496:Vesicular Glutamate Transport Proteins / Q000235:genetics*; D014786:Vision Disorders / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology; D014785:Vision, Ocular / Q000235:genetics; D015027:Zebrafish / Q000033:anatomy & histology / Q000378:metabolism*
D050496:Vesicular Glutamate Transport Proteins; D018698:Glutamic Acid