Stem cells of ependymoma.
Ependymomas are tumours that arise throughout the central nervous system. Little is known regarding the aberrant cellular and molecular processes that generate these tumours. This lack of knowledge has hampered efforts to reduce the significant mortality and morbidity that are associated with ependymoma. Here, we review recent data that suggest that radial glia are cells of origin of ependymoma, and discuss the processes that might transform these neural progenitors into ependymoma cancer stem cells.
Poppleton
H
H
Department of Developmental Neurobiology, St Jude Children's Research Hospital, 332 N Lauderdale Street, Memphis, TN 38105, USA.
Gilbertson
R J
RJ
D001932:Brain Neoplasms / Q000378:metabolism* / Q000473:pathology; D002471:Cell Transformation, Neoplastic; D016543:Central Nervous System Neoplasms / Q000378:metabolism* / Q000473:pathology; D004806:Ependymoma / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D008954:Models, Biological; D014411:Neoplastic Stem Cells / Q000378:metabolism* / Q000473:pathology; D009457:Neuroglia / Q000378:metabolism / Q000473:pathology; D015398:Signal Transduction