Acetylcholine-binding proteins: functional and structural homologs of nicotinic acetylcholine receptors.
Acetylcholine-binding protein (AChBP) is a water-soluble protein released from molluscan glial cells and modulates ACh-mediated synaptic transmission. Acetylcholine-binding protein (AChBP) is a water-soluble homolog of the ligand-binding domain of nicotinic receptors and other members of the pharmaceutically important family of pentameric ligand-gated ion channels (LGICs), GABAA, GABAC, 5-HT3 serotonin, and glycine receptors. The crystal structure of AChBP from Lymnaea stagnalis has become an established model for the extracellular domain of the pentameric LGICs, and homology models have been generated to analyze receptor-ligand interactions. AChBP has pharmacological properties similar to the homomeric alpha7 subtype of nicotinic ACh receptors (nAChRs), with relatively weak affinity for ACh and a 10-fold higher affinity for nicotine.
Smit
August B
AB
Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Faculty of Earth and Life Sciences, Vrije Universiteit, 1081 HV Amsterdam, The Netherlands. absmit@bio.vu.nl
Celie
Patrick H N
PH
Kasheverov
Igor E
IE
Mordvintsev
Dmitry Y
DY
van Nierop
Pim
P
Bertrand
Daniel
D
Tsetlin
Victor
V
Sixma
Titia K
TK
D000818:Animals; D002352:Carrier Proteins / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*; D020916:Conotoxins / Q000737:chemistry; D008195:Lymnaea / Q000378:metabolism*; D008978:Mollusk Venoms / Q000737:chemistry; D011487:Protein Conformation; D012908:Snails
C428944:AChBP protein, Lymnaea; D002352:Carrier Proteins; D020916:Conotoxins; D008978:Mollusk Venoms