[Role of brain mast cell in multiple sclerosis and Wernicke's encephalopathy].
Mast cell which is considered to participate in immune response has long been studied. However its true role in center nervous system is still unknown. Recently,mast cell has been found to play an important function during the process of multiple sclerosis and Wernicke's encephalopathy in the brain. Multiple sclerosis is an inflammatory demyelinating disease, and Wernicke's encephalopathy is caused by deficiency of thiamine. Mast cell deteriorates the neuronal damage and the course of diseases by their mediators. Such studies may supply new idea on the therapy of these diseases.
Pan
Jie
J
Department of Pharmacology, College of Medicine, Zhejiang University, Hangzhou 310058, China.
Hu
Wei-wei
WW
Chen
Zhong
Z
D000818:Animals; D001921:Brain / Q000473:pathology*; D006801:Humans; D008407:Mast Cells / Q000378:metabolism / Q000473:pathology*; D009103:Multiple Sclerosis / Q000378:metabolism / Q000473:pathology*; D014899:Wernicke Encephalopathy / Q000378:metabolism / Q000473:pathology*