Effect of different dialyzer membranes on cutaneous microcirculation during hemodialysis.
OBJECTIVE
Biocompatibility profiles of synthetic membranes may vary. In this prospective crossover study, we examined the effect of various membranes on cutaneous microcirculation during HD.


METHODS
11 HD patients without cardiovascular complications were enrolled in this study. They were dialyzed using three types of membrane in a randomized order: ethylene-vinyl alcohol copolymer (EVAL), vitamin E-bonded cellulose (VE-C) and polysulfone (PS). The transcutaneous oxygen tension (TcPO2) was examined on the dorsum of foot to assess the cutaneous microcirculation. Serum biochemical parameters were also measured.


RESULTS
The TcPO2 as a percentage of the predialysis level decreased from the beginning of HD, and significant differences were observed after 15 min of HD between EVAL and the other 2 membranes (98 +/- 6% (mean +/- SD) for EVAL versus 89 +/- 7% for VE-C (p < 0.01) and 88 +/- 10% for PS (p < 0.01)). Furthermore, there were significant differences at 30 and 60 min between EVAL and PS (30 min: 93 +/- 9% for EVAL versus 85 +/- 7% for PS (p < 0.05); 60 min: 92 +/- 10% for EVAL versus 79 +/- 10% for PS (p < 0.01)). The serum level of thiobarbituric acid reactants (TBARs), a marker of lipid peroxidation, increased significantly at the end of HD relative to that at the beginning of HD when using a PS membrane (from 1.9 +/- 0.5 to 2.1 +/- 0.5 nmol/ml, p < 0.05).


CONCLUSIONS
Our results indicate that an EVAL membrane is superior to PS and VE-C membranes in terms of its smaller influence on cutaneous microcirculation. The repeated occurrence of microcirculatory disturbance during HD sessions may cause chronic endothelial dysfunction and even cardiovascular complications in HD patients.
Sato
M
M
Department of Kidney and Dialysis, Social Insurance Chukyo Hospital, 1-1-10 Sanjou, Minami-ku, Nagoya 457-8510, Japan. motoyoshi_sato@chukyo-hosp.jp
Morita
H
H
Ema
H
H
Yamaguchi
S
S
Amano
I
I
D000328:Adult; D000368:Aged; D001672:Biocompatible Materials / Q000494:pharmacology; D001785:Blood Gas Monitoring, Transcutaneous; D018592:Cross-Over Studies; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000503:physiopathology / Q000628:therapy*; D008297:Male; D008567:Membranes, Artificial; D008833:Microcirculation / Q000187:drug effects / Q000502:physiology*; D008875:Middle Aged; D011108:Polymers / Q000494:pharmacology; D011145:Polyvinyls / Q000494:pharmacology; D011446:Prospective Studies; D006435:Renal Dialysis / Q000295:instrumentation*; D012867:Skin / Q000098:blood supply*; D013450:Sulfones / Q000494:pharmacology
D001672:Biocompatible Materials; D008567:Membranes, Artificial; D011108:Polymers; D011145:Polyvinyls; D013450:Sulfones; C020320:ethylene-vinyl alcohol copolymer; C017662:polysulfone P 1700