title: Human herpesvirus 8: serovprevalence and correlates in tumor patients from Xinjiang, China.
abstract: Human herpesvirus 8 (HHV-8), also known as Kaposi's sarcoma-associated herpesvirus, is etiologically associated with Kaposi's sarcoma and other lymphoproliferative diseases. Although HHV-8 prevalence exhibits considerable variation in different geographic regions and populations, the incidence of Kaposi's sarcoma appear to increase in areas with a high prevalence rate. In this study, an enzyme-linked immunosorbent assay based on mixed antigens of HHV-8 ORF(73), ORF(65), and K8.1 in the antigenic region was established and used to determine viral prevalence estimates and risk factors associated with HHV-8 infection. Of 482 tumor patients studied, the overall seropositivity of HHV-8 was 25.5%. Notably, Han people, who were immigrants or descendents of immigrants from inland of China, exhibited 26.4% seropositivity. This is similar to that observed in Uygur people, a local ethnic group with a high prevalence of HHV-8 infection and incidence of Kaposi's sarcoma. While there was no significant difference in patients with different tumors, HHV-8 seroprevalence was higher in individuals with malignant diseases. Logistic regression analysis suggests that the age is a risk factor associated with HHV-8 infection, with prevalence increasing from 12.5% under 20-27.5% above 50. These results suggest that unlike other parts of mainland of China, Xinjiang is an area with a high prevalence of HHV-8 infection.
authors.affiliation: The First Teaching Hospital of Xinjiang Medical University, Urumqi, Xingjiang, PR China.
authors.forename: Fangping
authors.initials: F
authors.lastname: He
authors.forename: Xing
authors.initials: X
authors.lastname: Wang
authors.forename: Bin
authors.initials: B
authors.lastname: He
authors.forename: Zongdi
authors.initials: Z
authors.lastname: Feng
authors.forename: Xiaomei
authors.initials: X
authors.lastname: Lu
authors.forename: Yaoxin
authors.initials: Y
authors.lastname: Zhang
authors.forename: Shujun
authors.initials: S
authors.lastname: Zhao
authors.forename: Renyong
authors.initials: R
authors.lastname: Lin
authors.forename: Yan
authors.initials: Y
authors.lastname: Hui
authors.forename: Yongxing
authors.initials: Y
authors.lastname: Bao
authors.forename: Zhaoxia
authors.initials: Z
authors.lastname: Zhang
authors.forename: Hao
authors.initials: H
authors.lastname: Wen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000914:Antibodies, Viral / Q000097:blood*; D002648:Child; D002681:China / Q000453:epidemiology; D005260:Female; D006566:Herpesviridae Infections / Q000453:epidemiology* / Q000821:virology; D019288:Herpesvirus 8, Human / Q000276:immunology* / Q000302:isolation & purification; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D012514:Sarcoma, Kaposi / Q000453:epidemiology* / Q000821:virology; D016036:Seroepidemiologic Studies
chemical_list: D000914:Antibodies, Viral