title: Antinociceptive effects of the aqueous extract of Brugmansia suaveolens flowers in mice.
abstract: The infusion of Brugmansia suaveolens, popularly known as trombeteira or cartucheira, has been used to treat pain in Brazil. The present study was conducted to test for its antinociceptive effects using the abdominal-writhing, formalin, tail-flick, and hot-plate tests in mice. The aqueous extract from B. suaveolens flowers administered intraperitoneally at doses of 100 and 300 mg/kg body weight significantly inhibited acetic acid-induced abdominal constrictions. An increase in hot-plate latency was also observed in animals receiving both doses (100 and 300 mg/kg). In the formalin test, both doses from the aqueous extract inhibited the first (0-5 min) and second phase (20-25 min). Tail-flick assays demonstrated that treatment of animals with plant extract induced attenuation of the response. These results suggest that the aqueous extract from B. suaveolens flowers produced antinociceptive effects, as demonstrated in the experimental models of nociception in mice. This supports popular medicinal uses of this plant as an analgesic.
authors.affiliation: Programa de Pós-Graduação em Enfermagem, Fundação Universidade Federal do Rio Grande, Rio Grande, Brazil.
authors.forename: Alexander Garcia
authors.initials: AG
authors.lastname: Parker
authors.forename: Gianni Goulart
authors.initials: GG
authors.lastname: Peraza
authors.forename: Janaina
authors.initials: J
authors.lastname: Sena
authors.forename: Eli Sinnott
authors.initials: ES
authors.lastname: Silva
authors.forename: Maria Cristina Flores
authors.initials: MC
authors.lastname: Soares
authors.forename: Marta Regina Cezar
authors.initials: MR
authors.lastname: Vaz
authors.forename: Eliana Badiale
authors.initials: EB
authors.lastname: Furlong
authors.forename: Ana Luiza
authors.initials: AL
authors.lastname: Muccillo-Baisch
mesh_terms: D019342:Acetic Acid; D000700:Analgesics / Q000494:pharmacology / Q000627:therapeutic use*; D000704:Analysis of Variance; D000818:Animals; D004008:Diclofenac / Q000627:therapeutic use; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D035264:Flowers; D005557:Formaldehyde; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice; D009020:Morphine / Q000627:therapeutic use; D010146:Pain / Q000139:chemically induced / Q000175:diagnosis / Q000188:drug therapy*; D010147:Pain Measurement / Q000379:methods; D008517:Phytotherapy / Q000379:methods*; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D011930:Reaction Time; D019657:Solanaceae; D016896:Treatment Outcome
chemical_list: D000700:Analgesics; D010936:Plant Extracts; D004008:Diclofenac; D005557:Formaldehyde; D009020:Morphine; D019342:Acetic Acid