title: Microwave-induced enzyme-catalyzed chemoselective reduction of organic azides.
abstract: A lipase enzyme, suspended in organic media along with organic azides and irradiated under microwaves, enhances the reaction rate over thermal heating and affords the corresponding amines in high yields. The present biocatalytic method employing lipase is a significant development with remarkable regio- and chemoselectivity under microwave irradiation in organic media with excellent yields for the reduction of azide functionality.
authors.affiliation: Department of Biochemistry, Regional Research Laboratory, Jorhat 785006, Assam, India.
authors.forename: Sharbani
authors.initials: S
authors.lastname: Mazumder
authors.forename: Dhrubojyoti D
authors.initials: DD
authors.lastname: Laskar
authors.forename: Dipak
authors.initials: D
authors.lastname: Prajapati
authors.forename: Manoj K
authors.initials: MK
authors.lastname: Roy
mesh_terms: D001386:Azides / Q000737:chemistry / Q000378:metabolism*; D002384:Catalysis; D008049:Lipase / Q000737:chemistry / Q000378:metabolism*; D008872:Microwaves; D010084:Oxidation-Reduction; D013379:Substrate Specificity / Q000502:physiology
chemical_list: D001386:Azides; D008049:Lipase