Self-administration of cocaine-antihistamine combinations: super-additive reinforcing effects.
Histamine H1 receptor antagonists have some behavioral effects that predict abuse liability. In the present study, diphenhydramine and cocaine each maintained i.v. self-administration under a progressive-ratio schedule in rhesus monkeys. When cocaine and DPH were combined in a 1:1 ratio of the ED50s, the combination was super-additive in all monkeys. The data predict that the combination of cocaine and histamine H1 receptor antagonists would have enhanced potential for abuse relative to either drug alone.
Wang
Zhixia
Z
Department of Psychiatry and Human, Behavior University of Mississippi Medical Center, Jackson, MS 39216, United States. Zwang@psychiatry.umsmed.edu
Woolverton
William L
WL
D000818:Animals; D003042:Cocaine / Q000008:administration & dosage / Q000494:pharmacology*; D004155:Diphenhydramine / Q000008:administration & dosage / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D006634:Histamine H1 Antagonists / Q000008:administration & dosage / Q000494:pharmacology*; D008253:Macaca mulatta; D008297:Male; D012055:Reinforcement Schedule; D012054:Reinforcement, Psychology; D012646:Self Administration / Q000523:psychology
D004338:Drug Combinations; D006634:Histamine H1 Antagonists; D004155:Diphenhydramine; D003042:Cocaine