title: The lymphopenic mouse in immunology: from patron to pariah.
abstract: A recent surge of interest in the behavior of T and B cells in lymphopenic model systems has resurrected a certain cynicism about the validity of using such models to answer important immunological questions. Here we discuss this skepticism in a broader historical context.
authors.affiliation: Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health, 4 / 111 Center Drive, MSC-0420, Bethesda, Maryland 20892, USA.
authors.forename: Nevil J
authors.initials: NJ
authors.lastname: Singh
authors.forename: Ronald H
authors.initials: RH
authors.lastname: Schwartz
mesh_terms: D019264:Adoptive Transfer; D000818:Animals; D001402:B-Lymphocytes / Q000528:radiation effects; D004195:Disease Models, Animal; D008231:Lymphopenia; D051379:Mice; D018448:Models, Immunological; D013601:T-Lymphocytes / Q000528:radiation effects