Downregulation of SOST/sclerostin by PTH: a novel mechanism of hormonal control of bone formation mediated by osteocytes.
Bellido
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Division of Endocrinology, Department of Internal Medicine and Center for Osteoporosis and Metabolic Bone Diseases, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA. tmbellido@uams.edu
D048868:Adaptor Proteins, Signal Transducing; D000818:Animals; D017209:Apoptosis / Q000502:physiology; D015519:Bone Density / Q000502:physiology; D019485:Bone Morphogenetic Proteins / Q000235:genetics / Q000378:metabolism*; D002452:Cell Count; D050659:Core Binding Factor Alpha 1 Subunit / Q000502:physiology; D015536:Down-Regulation / Q000502:physiology*; D005819:Genetic Markers / Q000235:genetics; D006023:Glycoproteins; D036341:Intercellular Signaling Peptides and Proteins; D051379:Mice; D008822:Mice, Transgenic; D010006:Osteoblasts / Q000166:cytology / Q000502:physiology; D010011:Osteocytes / Q000166:cytology / Q000502:physiology*; D010012:Osteogenesis / Q000502:physiology*; D010281:Parathyroid Hormone / Q000502:physiology*; D044168:Receptor, Parathyroid Hormone, Type 1 / Q000502:physiology
D048868:Adaptor Proteins, Signal Transducing; D019485:Bone Morphogenetic Proteins; D050659:Core Binding Factor Alpha 1 Subunit; D005819:Genetic Markers; D006023:Glycoproteins; D036341:Intercellular Signaling Peptides and Proteins; D010281:Parathyroid Hormone; D044168:Receptor, Parathyroid Hormone, Type 1; C493716:Runx2 protein, mouse; C486030:Sost protein, mouse