title: Rheumatoid keratolysis: a series of 40 eyes.
abstract: OBJECTIVE
  Rheumatoid keratolysis (RK) is a rare but a serious cause of ocular morbidity in rheumatoid patients. The aim of this study was to analyze the presenting features, the subsequent treatment, and the outcome of patients with RK in the authors' department.
  
  
  METHODS
  A retrospective study was undertaken of all patients with a diagnosis of RK at Bristol Eye Hospital between January 1987 and June 2002.
  
  
  RESULTS
  Forty eyes of 38 patients were identified in total. The mean age at presentation was 70 years. The mean duration of rheumatoid arthritis at presentation was 15 years. Most (22, 55%) ulcers were peripheral. Three patients (8%) developed RK within a month of cataract surgery. Out of the 19 patients who did not have a further RK, 11 were immunosuppressed. A total of 37 grafts were performed on 26 eyes. Twenty-two grafts (59%) failed. Immunosuppression increased the chance of anatomical success following penetrating keratoplasty. Infection was identified as a cause of graft failure for immunosuppressed patients in the postoperative period. Nine patients had reversible side effects from immunosuppressant treatment. Four eyes (10%) had to be surgically removed and a further 10 (25%) had severe visual loss (visual acuity less than 6/60). Eleven of the 38 patients subsequently died (29% mortality).
  
  
  CONCLUSIONS
  Although the visual prognosis is often poor, surgical preservation of the eye can be achieved by penetrating keratoplasty and systemic immunosuppression. With careful observation and regular monitoring, immunosuppressive medication appears to be safely tolerated in this group of patients.
authors.affiliation: Bristol Eye Hospital, Bristol, UK. rzmalik@doctors.org.uk
authors.forename: R
authors.initials: R
authors.lastname: Malik
authors.forename: A B
authors.initials: AB
authors.lastname: Culinane
authors.forename: D M
authors.initials: DM
authors.lastname: Tole
authors.forename: S D
authors.initials: SD
authors.lastname: Cook
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001172:Arthritis, Rheumatoid / Q000150:complications* / Q000175:diagnosis / Q000601:surgery; D003320:Corneal Ulcer / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D005260:Female; D006085:Graft Survival / Q000187:drug effects; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D015948:Keratoplasty, Penetrating; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012422:Rupture, Spontaneous; D015996:Survival Rate
chemical_list: D007166:Immunosuppressive Agents