title: Markers of human papillomavirus infection and their correlation with cervical dysplasia in human immunodeficiency virus-positive women.
abstract: Human papillomavirus (HPV) genotypes and HPV DNA load were analysed in cervical smears from 76 human immunodeficiency virus (HIV)-positive and 54 HIV-negative women. The prevalence of genotypes was similar for all women, with the exception of HPV62, which was over-represented in HIV-positive samples. HIV-positive women showed a higher prevalence of multiple genotypes that correlated neither with CD4(+) T-cell counts nor with cervical dysplasia. No significant differences were observed in terms of total or single-type HPV DNA load. The HPV DNA load in both HIV-positive and HIV-negative women was significantly higher in squamous intra-epithelial lesions than in negative Pap smears.
authors.affiliation: Virology Section, University Campus Bio-Medico, Spallanzani Hospital, Rome, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Riva
authors.forename: D
authors.initials: D
authors.lastname: Serraino
authors.forename: A
authors.initials: A
authors.lastname: Pierangeli
authors.forename: F
authors.initials: F
authors.lastname: Bambacioni
authors.forename: S
authors.initials: S
authors.lastname: Zaniratti
authors.forename: C
authors.initials: C
authors.lastname: Minosse
authors.forename: M
authors.initials: M
authors.lastname: Selleri
authors.forename: M
authors.initials: M
authors.lastname: Bucci
authors.forename: C
authors.initials: C
authors.lastname: Scagnolari
authors.forename: A M
authors.initials: AM
authors.lastname: Degener
authors.forename: M R
authors.initials: MR
authors.lastname: Capobianchi
authors.forename: G
authors.initials: G
authors.lastname: Antonelli
authors.forename: F
authors.initials: F
authors.lastname: Dianzani
mesh_terms: D000328:Adult; D004279:DNA, Viral / Q000235:genetics; D005260:Female; D005819:Genetic Markers / Q000235:genetics; D006678:HIV; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D008875:Middle Aged; D018307:Neoplasms, Squamous Cell / Q000150:complications* / Q000821:virology*; D027383:Papillomaviridae / Q000145:classification / Q000235:genetics*; D030361:Papillomavirus Infections / Q000150:complications* / Q000821:virology*; D016133:Polymerase Chain Reaction; D013045:Species Specificity; D002578:Uterine Cervical Dysplasia / Q000150:complications* / Q000821:virology*
chemical_list: D004279:DNA, Viral; D005819:Genetic Markers