title: Bovine casein hydrolysate (c12 Peptide) reduces blood pressure in prehypertensive subjects.
abstract: BACKGROUND
  About one in four adults suffer from prehypertension. People with prehypertension are at risk of developing hypertension, being a biomarker for cardiovascular disease risk. The use of milk-derived protein hydrolysates containing peptides with angiotensin-converting enzyme (ACE) inhibiting properties may reduce blood pressure (BP) and thus the risk of developing hypertension.
  
  
  METHODS
  We investigated the BP-lowering effect of a casein-derived protein hydrolysate (C12 Peptide) during a 4-week intervention period in prehypertensive subjects. After a 2-week run-in period, 48 Taiwanese volunteers were randomly assigned to either placebo or C12 Peptide tablets for 4 weeks, followed by a 2-week off-treatment period. After the run-in period, BP was measured weekly.
  
  
  RESULTS
  Baseline values for systolic BP (mean +/- SEM) in the placebo and C12 Peptide groups were 137.1 +/- 3.1 and 137.9 +/- 2.4 mm Hg, respectively; those for diastolic BP were 85.2 +/- 2.1 and 86.9 +/- 2.0 mm Hg, respectively. Four weeks repeated daily intake of 3.8 g C12 Peptide reduced significantly systolic and diastolic BP by 10.7 +/- 1.6 mm Hg and 6.9 +/- 1.2 mm Hg, respectively, compared to baseline. Furthermore, plasma angiotensin II and aldosterone levels were reduced significantly (P < .05). The placebo group showed a BP reduction of 3.6 +/- 2.4 and 2.7 +/- 1.6 mm Hg in systolic and diastolic BP, respectively (P = not significant). No evidence of side effects was observed.
  
  
  CONCLUSIONS
  This study shows that C12 Peptide reduces BP in prehypertensive people.
authors.affiliation: DMV International, Veghel, The Netherlands.
authors.forename: Jenny A
authors.initials: JA
authors.lastname: Cadée
authors.forename: Chou-Yue
authors.initials: CY
authors.lastname: Chang
authors.forename: Chien-Wei
authors.initials: CW
authors.lastname: Chen
authors.forename: Chien-Ning
authors.initials: CN
authors.lastname: Huang
authors.forename: Su-Lin
authors.initials: SL
authors.lastname: Chen
authors.forename: Chin-Kun
authors.initials: CK
authors.lastname: Wang
mesh_terms: D000450:Aldosterone / Q000097:blood; D000804:Angiotensin II / Q000097:blood; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000009:adverse effects / Q000627:therapeutic use*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D002364:Caseins / Q000009:adverse effects / Q000627:therapeutic use; D002417:Cattle; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006973:Hypertension / Q000517:prevention & control*; D008297:Male; D008875:Middle Aged
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D002364:Caseins; D000804:Angiotensin II; D000450:Aldosterone; C475729:casein hydrolysate