title: Chemical genetics: an evolving toolbox for target identification and lead optimization.
abstract: Chemical genetics combines chemistry with biology as a means of exploring the function of unknown proteins or identifying the proteins responsible for a particular phenotype. Chemical genetics is thus a valuable tool in the identification of novel drug targets. This chapter describes the application of chemical genetics in traditional and systems-based approaches to drug target discovery and the tools/approaches that appear most promising for guiding future pharmaceutical development.
authors.affiliation: National Institutes of Health, Rockville, MD 20852, USA. hboshoff@niaid.nih.gov
authors.forename: Helena I
authors.initials: HI
authors.lastname: Boshoff
authors.forename: Cynthia S
authors.initials: CS
authors.lastname: Dowd
mesh_terms: D020650:Combinatorial Chemistry Techniques; D015195:Drug Design; D005823:Genetics; D023281:Genomics; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D010641:Phenotype; D011485:Protein Binding; D011506:Proteins / Q000502:physiology*; D049490:Systems Biology; D014158:Transcription, Genetic
chemical_list: D011506:Proteins