title: Stability of moxifloxacin injection in peritoneal dialysis solution bags (Dianeal PD1 1.36% and Dianeal PD1 3.86%).
abstract: OBJECTIVE
  Moxifloxacin is a new fluorquinolone with broad-spectrum activity. It is suitable for treating peritonitis in peritoneal dialysis (PD) patients. The objective of this study was to test stability of moxifloxacin in PD solutions stored at different temperatures.
  
  
  METHODS
  Dialysis solution bags were used at two glucose concentrations; Dianeal PD1 1.36% and Dianeal PD1 3.86%. Moxifloxacin solution (2%) was injected into nine 2-L bags of Dianeal PD1 1.36% and nine bags of Dianeal PD1 3.86% under aseptic conditions to achieve a nominal concentration of 25 mg/L. Three bags of Dianeal PD1 1.36% and three bags of Dianeal PD1 3.86% were stored at each of three temperatures (4, 25 and 37 degrees C) and the same way for. Duplicate samples (2 mL) were taken at different times and precipitation, cloudiness, colour and pH was analysed. Moxifloxacin concentrations were measured using a modified HPLC method.
  
  
  RESULTS
  The mean moxifloxacin concentration in the Dianeal PD1 1.36% solution remained > or =90% of the initial concentration for 14 days at 4 degrees C, 7 days at 25 degrees C and 3 days at 37 degrees C. For Dianeal PD1 3.86% moxifloxacin concentrations remained > or =90% for 14 days at 4 degrees C, 3 days at 25 degrees C and 12 h at 37 degrees C.
  
  
  CONCLUSIONS
  Moxifloxacin shows sufficient stability in both PD bags for use in PD patients.
authors.affiliation: Department of Pharmacology, Faculty of Medicine, University of Murcia, Murcia, Spain. emiliofv@um.es
authors.forename: E
authors.initials: E
authors.lastname: Fernández-Varón
authors.forename: P
authors.initials: P
authors.lastname: Marín
authors.forename: A
authors.initials: A
authors.lastname: Espuny
authors.forename: L
authors.initials: L
authors.lastname: Villamayor
authors.forename: E
authors.initials: E
authors.lastname: Escudero
authors.forename: C
authors.initials: C
authors.lastname: Cárceles
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry*; D001372:Aza Compounds / Q000032:analysis / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D015314:Dialysis Solutions; D004355:Drug Stability; D024841:Fluoroquinolones; D007267:Injections; D000077266:Moxifloxacin; D010530:Peritoneal Dialysis; D011804:Quinolines / Q000032:analysis / Q000737:chemistry*; D013696:Temperature
chemical_list: D000890:Anti-Infective Agents; D001372:Aza Compounds; D015314:Dialysis Solutions; D024841:Fluoroquinolones; D011804:Quinolines; D000077266:Moxifloxacin