title: Dopaminergic modulation and rod contribution in the generation of oscillatory potentials in the tiger salamander retina.
abstract: The roles of rod and cone input and of dopamine in the generation of oscillatory potentials were studied in tiger salamander retina. Under scotopic conditions, oscillations were elicited with a green, but not a red stimulus. With mesopic background illumination, both stimuli caused oscillations. Addition of quinpirole to a mesopic retina eliminated oscillations while SKF-38393 had no effect. Similarly, addition of sulpiride to a light-adapted retina elicited oscillatory activity, but SCH 22390 had no effect. These results suggest that oscillatory potentials are elicited through activation of the rod pathway and are modulated by dopamine through D2-receptors.
authors.affiliation: Applied Modern Physics, Los Alamos National Laboratory, Los Alamos, NM, USA. bperry@lanl.gov
authors.forename: B
authors.initials: B
authors.lastname: Perry
authors.forename: J S
authors.initials: JS
authors.lastname: George
mesh_terms: D000222:Adaptation, Physiological / Q000502:physiology / Q000528:radiation effects; D000557:Ambystoma / Q000502:physiology*; D000818:Animals; D001683:Biological Clocks / Q000502:physiology*; D065127:Dopamine D2 Receptor Antagonists; D004596:Electroretinography; D010775:Photic Stimulation / Q000379:methods; D011954:Receptors, Dopamine / Q000502:physiology*; D017447:Receptors, Dopamine D1 / Q000819:agonists / Q000037:antagonists & inhibitors / Q000502:physiology; D017448:Receptors, Dopamine D2 / Q000819:agonists / Q000502:physiology; D012160:Retina / Q000502:physiology*; D017949:Retinal Cone Photoreceptor Cells / Q000502:physiology / Q000528:radiation effects; D017948:Retinal Rod Photoreceptor Cells / Q000502:physiology / Q000528:radiation effects
chemical_list: D065127:Dopamine D2 Receptor Antagonists; D011954:Receptors, Dopamine; D017447:Receptors, Dopamine D1; D017448:Receptors, Dopamine D2