The pathogenic role of tissue-resident immune cells in psoriasis.
Psoriasis is a common chronic inflammatory skin disease, the study of which might also be of considerable value to the understanding of other inflammatory and autoimmune-type diseases, such as rheumatoid arthritis, inflammatory bowel disease, multiple sclerosis and diabetes mellitus. There is clear evidence that T cells and dendritic cells have a central role in psoriasis. Based on recent data from humans and animal models, we propose that a psoriasis lesion can be triggered and sustained by the local network of skin-resident immune cells. This concept focuses attention on local, rather than systemic, components of the immune system for rationalized therapeutic approaches of psoriasis and possibly also other chronic inflammatory diseases.
Boyman
Onur
O
Division of Immunology and Allergy, University Hospital of Lausanne (CHUV), CH-1011 Lausanne, Switzerland. onur.boyman@chuv.ch
Conrad
Curdin
C
Tonel
Giulia
G
Gilliet
Michel
M
Nestle
Frank O
FO
D000818:Animals; D002908:Chronic Disease; D006801:Humans; D007249:Inflammation / Q000235:genetics / Q000276:immunology / Q000473:pathology / Q000628:therapy; D011565:Psoriasis / Q000235:genetics / Q000276:immunology* / Q000473:pathology* / Q000628:therapy