title: Three new immunomodulating C21-steroidal glycosides from the stems of Stephanotis mucronata.
abstract: Three new C(21)-steroidal glycosides stemucronatosides H, I, and J (1-3, resp.) were isolated from the stems of Stephanotis mucronata, together with three known compounds sinomarinoside A (4), sinomarinoside E (5), and stephanoside H (6). These isolated compounds were tested for their immunological activities in vitro against concanavalin-A(Con A)- and lipopolysaccharide(LPS)-induced proliferation of mice splenocytes. Compounds 3, 4, and 6 showed immunosuppressive activities in a dose-dependent manner, while compounds 1, 2, and 5 possessed immunoenhancing activities.
authors.affiliation: Department of Chemistry, Zhejiang University, Hangzhou 310027, PR China.
authors.forename: Xiaoyu
authors.initials: X
authors.lastname: Li
authors.forename: Hongxiang
authors.initials: H
authors.lastname: Sun
authors.forename: Yiping
authors.initials: Y
authors.lastname: Ye
authors.forename: Fengyang
authors.initials: F
authors.lastname: Chen
authors.forename: Jue
authors.initials: J
authors.lastname: Tu
authors.forename: Yuanjiang
authors.initials: Y
authors.lastname: Pan
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007155:Immunologic Factors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D051379:Mice; D010840:Phytosterols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018547:Plant Stems; D013154:Spleen / Q000166:cytology / Q000187:drug effects
chemical_list: D006027:Glycosides; D007155:Immunologic Factors; D010840:Phytosterols; D010936:Plant Extracts