Vancomycin-resistant Enterococcus faecalis endocarditis: linezolid failure and strain characterization of virulence factors.
Infective endocarditis due to vancomycin-resistant (VR) Enterococcus faecalis has only rarely been reported. We report a case of VR E. faecalis endocarditis that failed to respond to linezolid therapy, outline the virulence traits of the isolate, and review previously published cases of VR E. faecalis endocarditis.
Tsigrelis
Constantine
C
Division of Infectious Diseases, Department of Medicine, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA. tsigrelis.constantine@mayo.edu
Singh
Kavindra V
KV
Coutinho
Thais D
TD
Murray
Barbara E
BE
Baddour
Larry M
LM
D000081:Acetamides / Q000627:therapeutic use*; D000328:Adult; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D004697:Endocarditis, Bacterial / Q000188:drug therapy* / Q000382:microbiology; D013293:Enterococcus faecalis / Q000145:classification / Q000187:drug effects* / Q000472:pathogenicity*; D005260:Female; D016908:Gram-Positive Bacterial Infections / Q000188:drug therapy / Q000382:microbiology; D006801:Humans; D000069349:Linezolid; D023303:Oxazolidinones / Q000627:therapeutic use*; D017211:Treatment Failure; D020713:Vancomycin Resistance; D014774:Virulence; D037521:Virulence Factors / Q000235:genetics / Q000378:metabolism
D000081:Acetamides; D000890:Anti-Infective Agents; D001426:Bacterial Proteins; D023303:Oxazolidinones; D037521:Virulence Factors; D000069349:Linezolid