title: Erythroleukaemia, diabetes insipidus and hypophyseal damage: Two case reports.
abstract: We report on two cases of patients who developed diabetes insipidus (DI) before acute erythroleukaemia (EL). A brain MRI showed an empty sella turcica in one case and hypothalamo-hypophyseal peduncle damage in the second case. Reduced levels of TGF-beta1 and Vitamin D3, with associated EVI-1 over-expression and karyotypic abnormalities were documented. These two cases show specific chromosomal/molecular alterations in EL with DI. The hypothesis of pituitary involvement in erythroleukemogenesis is discussed.
authors.affiliation: Department of Haematology, S Bortolo Hospital, Vicenza, Italy. andrea.piccin@ibts.ie
authors.forename: A
authors.initials: A
authors.lastname: Piccin
authors.forename: R
authors.initials: R
authors.lastname: Raimondi
authors.forename: S
authors.initials: S
authors.lastname: Laspina
authors.forename: M
authors.initials: M
authors.lastname: Marchi
authors.forename: F
authors.initials: F
authors.lastname: Rodeghiero
authors.forename: U
authors.initials: U
authors.lastname: Rovigatti
mesh_terms: D000328:Adult; D002762:Cholecalciferol / Q000097:blood; D002869:Chromosome Aberrations; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D003919:Diabetes Insipidus / Q000150:complications* / Q000175:diagnosis / Q000378:metabolism; D004652:Empty Sella Syndrome / Q000139:chemically induced* / Q000175:diagnosis / Q000378:metabolism; D005260:Female; D006801:Humans; D007027:Hypothalamic Diseases / Q000150:complications* / Q000175:diagnosis / Q000378:metabolism; D004915:Leukemia, Erythroblastic, Acute / Q000150:complications* / Q000175:diagnosis / Q000378:metabolism; D000074008:MDS1 and EVI1 Complex Locus Protein; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010902:Pituitary Gland / Q000473:pathology*; D011519:Proto-Oncogenes / Q000235:genetics; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism; D053773:Transforming Growth Factor beta1 / Q000378:metabolism
chemical_list: D004268:DNA-Binding Proteins; D000074008:MDS1 and EVI1 Complex Locus Protein; C063575:MECOM protein, human; D014157:Transcription Factors; D053773:Transforming Growth Factor beta1; D002762:Cholecalciferol