title: The histopathological effect of intracameral ropivacaine in different concentrations on corneal endothelium.
abstract: We evaluated the histopathological changes occurring in corneal endothelium after intracameral injection ropivacaine into rats. Intracamerally administered ropivacaine in 1, 0.5, and 0.1% concentrations resulted in impairment of hexagonal structure of corneal endothelial cells and intercellular junctions, destruction of microvilli on the cell surface, roughness of cell borders, picnotic nucleus, diffuse vacuolization, and crystalysis in mitochondria.
authors.affiliation: Department of Ophthalmology, Dicle University Faculty of Medicine, Diyarbakir, Turkey. ihsancaca@mynet.com
authors.forename: Ihsan
authors.initials: I
authors.lastname: Caça
authors.forename: Vatan
authors.initials: V
authors.lastname: Kavak
authors.forename: Kaan
authors.initials: K
authors.lastname: Unlü
authors.forename: Seyhmus
authors.initials: S
authors.lastname: Ari
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Nergis
authors.forename: Gülnür
authors.initials: G
authors.lastname: Take
mesh_terms: D000577:Amides / Q000008:administration & dosage / Q000633:toxicity*; D000779:Anesthetics, Local / Q000008:administration & dosage / Q000633:toxicity*; D000818:Animals; D000867:Anterior Chamber / Q000187:drug effects*; D004728:Endothelium, Corneal / Q000187:drug effects* / Q000648:ultrastructure*; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D051381:Rats; D017208:Rats, Wistar; D000077212:Ropivacaine
chemical_list: D000577:Amides; D000779:Anesthetics, Local; D000077212:Ropivacaine