Friendly and dangerous signals: is the tissue in control?
In their own defense, tissues send a panoply of signals that initiate immunity and guide the choice of effector class. T(H)1-T(H)2 and T(reg) is far too simple a representation of the breathtaking variety of the resulting responses.
Matzinger
Polly
P
Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA. pcm@helix.nih.gov
D000818:Animals; D006801:Humans; D007109:Immunity; D007136:Immunoglobulins / Q000096:biosynthesis* / Q000145:classification; D015398:Signal Transduction; D006377:T-Lymphocytes, Helper-Inducer / Q000145:classification* / Q000276:immunology*; D018417:Th1 Cells / Q000276:immunology; D018418:Th2 Cells / Q000276:immunology
D007136:Immunoglobulins