A new S4-ligated zinc-peptide 1:2 complex for the hydrolytic cleavage of DNA.
A new sulfur-ligated Zn-peptide 1:2 complex, [Zn(II)(Boc-NH-Cys-Gly-Cys-OMe)2]2- (2), was prepared, characterized, and tested for its DNA-binding and -cleavage properties. Complex 2 was found to cleave DNA hydrolytically. The negative charge in 2 reduces the affinity of the complex for DNA, and enhances its binding specificity.
Reddy
Pulimamidi R
PR
Department of Chemistry, Osmania University, Hyderabad-500 007, India. rabi_pr@rediffmail.com
Mohan
Sepuru K
SK
Manjula
Pallerla
P
Chakraborty
Tushar K
TK
D004247:DNA / Q000032:analysis / Q000737:chemistry* / Q000378:metabolism; D006868:Hydrolysis; D010455:Peptides / Q000032:analysis / Q000737:chemistry* / Q000378:metabolism; D011485:Protein Binding / Q000502:physiology; D015032:Zinc / Q000032:analysis / Q000737:chemistry* / Q000378:metabolism
D010455:Peptides; D004247:DNA; D015032:Zinc