The prophylactic effectiveness of various antifungal agents against the progression of trichosporonosis fungemia to disseminated disease in a neutropenic mouse model.
Neutropenic mice with latent trichosporonemia were given various antifungal agents (amphotericin B, fluconazole, itraconazole) or saline to determine which antifungal agent could be useful for prophylaxis. The 3-week-survival rate was 80% in the fluconazole group, 50% in the amphotericin B group, 45% in the itraconazole group, and 30% in the saline group. Compared with the other antifungal agents, fluconazole offered superior prophylaxis against the progression of trichosporonosis fungemia to disseminated disease (P<0.05). These results suggest that clinical studies are warranted to investigate fluconazole prophylaxis of trichosporonosis progression in neutropenic patients, such as people receiving chemotherapy and patients who have received solid organ transplants.
Tokimatsu
Issei
I
Department of Infectious Diseases, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-machi, Yufu, Oita 879-5593, Japan. issei@med.oita-u.ac.jp
Kushima
Hisako
H
Hashinaga
Kazuhiko
K
Umeki
Kenji
K
Ohama
Minoru
M
Ishii
Hiroshi
H
Kishi
Kenji
K
Hiramatsu
Kazufumi
K
Kadota
Jun-Ichi
J
D000666:Amphotericin B / Q000494:pharmacology / Q000627:therapeutic use; D000825:Animal Structures / Q000473:pathology; D000818:Animals; D019072:Antibiotic Prophylaxis; D000935:Antifungal Agents / Q000494:pharmacology / Q000627:therapeutic use*; D003520:Cyclophosphamide / Q000494:pharmacology; D004195:Disease Models, Animal; D015725:Fluconazole / Q000494:pharmacology / Q000627:therapeutic use; D016469:Fungemia / Q000150:complications / Q000188:drug therapy* / Q000382:microbiology; D017964:Itraconazole / Q000494:pharmacology / Q000627:therapeutic use; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D008826:Microbial Sensitivity Tests; D009503:Neutropenia / Q000139:chemically induced / Q000150:complications*; D016019:Survival Analysis; D016896:Treatment Outcome; D014250:Trichosporon / Q000187:drug effects*
D000935:Antifungal Agents; D017964:Itraconazole; D000666:Amphotericin B; D003520:Cyclophosphamide; D015725:Fluconazole