title: Slicer and the argonautes.
abstract: Though they started out as somewhat mysterious components of the RNAi effector complexes, Argonaute proteins have since taken center stage in RNAi gene silencing. They interact with small RNAs to effect gene silencing in all RNAi-related pathways known so far. We will review the dramatic advances in our understanding of the role of the Argonautes in RNAi through studies of their structure and function.
authors.affiliation: W.M. Keck Structural Biology Laboratory, Cold Spring Harbor, New York 11724, USA.
authors.forename: Niraj H
authors.initials: NH
authors.lastname: Tolia
authors.forename: Leemor
authors.initials: L
authors.lastname: Joshua-Tor
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D006801:Humans; D008958:Models, Molecular; D010448:Peptide Initiation Factors / Q000737:chemistry / Q000502:physiology*; D017434:Protein Structure, Tertiary; D020027:Pyrococcus furiosus / Q000737:chemistry / Q000502:physiology; D034622:RNA Interference / Q000502:physiology*; D012323:RNA Processing, Post-Transcriptional; D043244:Ribonuclease III / Q000145:classification / Q000502:physiology*; D029702:Schizosaccharomyces pombe Proteins / Q000737:chemistry / Q000502:physiology; D016415:Sequence Alignment; D015398:Signal Transduction
chemical_list: D010448:Peptide Initiation Factors; D029702:Schizosaccharomyces pombe Proteins; D043244:Ribonuclease III