title: Effects of chronic stress on the immune response to oral human serum albumin-conjugated starch microparticles in rats.
abstract: Uptake of antigens and bacteria over the follicle-associated epithelium (FAE) is increased after chronic psychological stress. We investigated whether stress affects the immune response to particle-conjugated antigens taken up via the FAE. Rats were submitted to two 10-day periods of water avoidance stress and orally immunized during these periods. Stressed immunized rats displayed altered cell populations and a Th1-skewed immune response within the lymphoid follicles, together with enhanced delayed-type hypersensitivity. We conclude that chronic stress affects the cell-mediated immune response after oral immunization, which may have implications for the understanding of allergic and autoimmune diseases and development of oral vaccines.
authors.affiliation: Department of Biomedicine and Surgery, Division of Surgery, Faculty of Health Sciences, Linköping University, Sweden.
authors.forename: Asa V
authors.initials: AV
authors.lastname: Keita
authors.forename: Linda
authors.initials: L
authors.lastname: Stertman
authors.forename: Yi-Qian
authors.initials: YQ
authors.lastname: Sun
authors.forename: Agneta
authors.initials: A
authors.lastname: Larhed
authors.forename: Ingvar
authors.initials: I
authors.lastname: Sjöholm
authors.forename: Johan D
authors.initials: JD
authors.lastname: Söderholm
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000943:Antigens, Differentiation / Q000378:metabolism; D016827:CD8 Antigens / Q000378:metabolism; D002908:Chronic Disease; D016207:Cytokines / Q000378:metabolism; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D005434:Flow Cytometry / Q000379:methods; D005786:Gene Expression Regulation / Q000502:physiology; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000209:etiology / Q000276:immunology; D008297:Male; D010581:Peyer's Patches / Q000276:immunology / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012709:Serum Albumin / Q000008:administration & dosage / Q000276:immunology*; D013213:Starch / Q000008:administration & dosage* / Q000276:immunology; D013315:Stress, Psychological / Q000276:immunology* / Q000473:pathology; D013997:Time Factors
chemical_list: D000943:Antigens, Differentiation; D016827:CD8 Antigens; D016207:Cytokines; C459465:OX-62 antigen, rat; D012709:Serum Albumin; D013213:Starch