Solid-phase synthesis and CD spectroscopic investigations of novel beta-peptides from L-aspartic acid and beta-amino-L-alanine.
[structure: see text] A solid-phase synthesis method for the preparation of novel beta3- and beta2-peptides derived from l-aspartic acid and beta-amino-l-alanine, respectively, is described. The methodology allows independent buildup of the beta-peptide backbone and the introduction of sequential side chain substitutions. Representative peptides from the two classes, an amino-substituted beta3-hexapeptide and an acyl-substituted beta2-hexapeptide, have been prepared, and their solution conformation is studied by circular dichroism (CD) spectroscopy.
Ahmed
Sahar
S
Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada.
Beleid
Reem
R
Sprules
Tara
T
Kaur
Kamaljit
K
D000586:Amination; D001224:Aspartic Acid / Q000737:chemistry*; D002942:Circular Dichroism; D015394:Molecular Structure; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry; D011422:Propionates / Q000737:chemistry; D015091:beta-Alanine / Q000737:chemistry*
D010455:Peptides; D011422:Propionates; D015091:beta-Alanine; D001224:Aspartic Acid; C029658:propionic acid