Outcome of in vitro fertilization in women 45 years and older who use autologous oocytes.
OBJECTIVE
To determine the IVF outcome in women over the age of 44 years.


METHODS
Retrospective analysis.


METHODS
University-based IVF center.


METHODS
Two hundred eighty-eight consecutive IVF cycles in women over the age of 44 years.


METHODS
IVF.


METHODS
Ovarian response and cycle outcome.


RESULTS
The mean age of the patients was 45.4 (+/-0.73) years, with a range of 45-49 years. Fifty-seven of 288 (19.8%) did not start because of an elevated FSH or ovarian cyst. Just over 30% (70/231) had their cycle cancelled before retrieval. The mean number of oocytes was 6.8 (+/-3.8), and the mean number of fertilized zygotes was 5.4 (+/-3.4). On average, the mean numbers of embryos replaced were 3.2 (+/-1.5). An overall pregnancy rate of 21.1% (34/161) per retrieval was found. Of these, 85.3% (29/34) experienced a pregnancy loss. The overall delivery rate was 3.1% (5/161) per retrieval. Only patients at 45 years of age with a good response (>5 oocytes) achieved a delivery.


CONCLUSIONS
We have shown that IVF is a reasonable option for women of very advanced maternal age (>44 years) but is limited to those at the age of 45 years with a response of >5 oocytes.
Spandorfer
Steven D
SD
The Center for Reproductive Medicine and Infertility, The New York Presbyterian Hospital/Weill Medical College of Cornell University, New York, New York 10021, USA. sdspando@med.cornell.edu
Bendikson
Kristin
K
Dragisic
Kate
K
Schattman
Glenn
G
Davis
Owen K
OK
Rosenwaks
Zev
Z
D000367:Age Factors; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods / Q000706:statistics & numerical data*; D006801:Humans; D008875:Middle Aged; D009518:New York; D009865:Oocytes / Q000637:transplantation*; D017063:Outcome Assessment, Health Care; D011247:Pregnancy; D011256:Pregnancy Outcome / Q000453:epidemiology*; D012189:Retrospective Studies; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D014182:Transplantation, Autologous / Q000706:statistics & numerical data*; D016896:Treatment Outcome