Serodiagnosis of dengue virus infection in patients presenting to a tertiary care hospital.
Dengue is an acute infectious disease of viral etiology. It is probably one of the most important arthropod borne viral disease in terms of human morbidity and mortality. The spectrum of disease ranges from self-limited dengue fever to more severe forms of dengue hemorrhagic fever (DHF) or dengue shock syndrome (DSS). Laboratory diagnosis of dengue virus infection mainly depends on detection of virus specific antibodies. The aim of the study was to correlate the serological results with clinical presentation in patients with a diagnosis of dengue. Eleven out of 15 (73.3%) patients with DHF and DSS had secondary antibody response and mortality was 100% in these patients.
Neeraja
M
M
Department of Microbiology, Nizam's Institute of Medical Sciences, Punjagutta, Hyderabad--500 082, Andhra Pradesh, India. lgorthi@hotmail.com
Lakshmi
V
V
Teja
V D
VD
Umabala
P
P
Subbalakshmi
M V
MV
D000046:Academic Medical Centers; D000293:Adolescent; D000328:Adult; D000368:Aged; D000914:Antibodies, Viral / Q000097:blood*; D002648:Child; D003715:Dengue / Q000175:diagnosis* / Q000401:mortality / Q000503:physiopathology* / Q000821:virology; D003716:Dengue Virus / Q000276:immunology*; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D007194:India / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D012698:Serologic Tests; D019595:Severe Dengue / Q000175:diagnosis / Q000401:mortality / Q000503:physiopathology / Q000821:virology; D012772:Shock, Septic / Q000175:diagnosis / Q000401:mortality / Q000821:virology
D000914:Antibodies, Viral; D007074:Immunoglobulin G; D007075:Immunoglobulin M