title: Infection-associated hemophagocytic syndrome: a rare potentially fatal complication of systemic infection. Report of three cases.
abstract: Infection-associated hemophagocytic syndrome is a rare, potentially fatal complication of systemic infection. It occurs most often in immunocompromised patients associated with a viral infection but the spectrum of conditions have been broadened to include virtually every type of infectious pathogen, malignancy and immunosuppressive therapy. We present three pediatric patients with a similar clinical history of pancytopenia, hepatosplenomegaly, and acute liver failure, and discuss the autopsy findings.
authors.affiliation: Department of Pathology and Laboratory Medicine, Medical Sciences Campus, University of Puerto Rico, San Juan, Puerto Rico.
authors.forename: Ilia M
authors.initials: IM
authors.lastname: Morales-Melecio
authors.forename: María S
authors.initials: MS
authors.lastname: Correa-Rivas
authors.forename: Alicia
authors.initials: A
authors.lastname: Fernández-Sein
authors.forename: Gloria
authors.initials: G
authors.lastname: Colón-González
mesh_terms: D001344:Autopsy; D001706:Biopsy; D001853:Bone Marrow / Q000473:pathology; D016638:Critical Illness; D005260:Female; D006801:Humans; D007223:Infant; D007239:Infections / Q000150:complications*; D051359:Lymphohistiocytosis, Hemophagocytic / Q000175:diagnosis / Q000209:etiology / Q000401:mortality / Q000473:pathology; D008297:Male; D013154:Spleen / Q000473:pathology; D013577:Syndrome; D013997:Time Factors