Is Crohn's disease due to defective immunity?
The understanding of the pathophysiology of Crohn's disease is currently undergoing a reassessment. The concept of this disease as a primary T cell disorder is being questioned, with a new emphasis on the role of innate immunity in initiating early events and in perpetuating the inflammatory state. Crohn's disease has been proposed instead to result from impaired innate immunity, encompassing the mucosal barrier and cellular elements including neutrophils and macrophages. Recent advances in genetics, functional studies on innate immunity and therapeutic trials on patients with Crohn's disease have lent support to this evolving hypothesis.
Korzenik
J R
JR
Department of Internal Medicine, Massachusetts General Hospital, MGH Crohn's and Colitis Center, 165 Cambridge Street, 9th floor, Boston, MA 02114, USA. jkorzenik@partners.org
D003424:Crohn Disease / Q000235:genetics / Q000276:immunology* / Q000382:microbiology; D016207:Cytokines / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology; D008264:Macrophages / Q000276:immunology; D009504:Neutrophils / Q000276:immunology; D053473:Nod2 Signaling Adaptor Protein / Q000235:genetics / Q000276:immunology; D012307:Risk Factors; D013601:T-Lymphocytes / Q000276:immunology
D016207:Cytokines; C429018:NOD2 protein, human; D053473:Nod2 Signaling Adaptor Protein