[Alteration of bronchomotor tone after deep inhalation. Mechanisms and pediatric data].
There is significant alteration of airway calibre after deep inhalation (DI). An increase of airway calibre has been evidenced in children in case of mild asthmatic obstruction and after a positive response to methacholine or exercise challenge. Such an increase is blunted in the presence of a moderate to severe asthmatic airway obstruction and no bronchodilatory effect of DI has been found in infants. Bronchial hyperreactivity and airway inflammation strongly influence post-DI alterations of bronchomotor tone. Airways and lung parenchyma are interdependent but both exhibit imperfect elasticity. Hysterisis characterizes imperfect elasticity of pressure-volume relationship. The mechanical theory of relative hysteresis between airway and lung parenchyma is the main mechanism implicated in the induced changes of airway calibre. DI may influence results of lung function testing in children. The technique may be of interest to increase sensibility of routine lung function testing in children.
Schweitzer
C
C
Service d'explorations fonctionnelles pédiatriques, hôpital d'Enfants, centre hospitalier universitaire de Nancy, 54511 Vandoeuvre-Lès-Nancy, France. cyril.schweitzer@medecine.uhp-nancy.fr
Marchal
F
F
D001249:Asthma / Q000628:therapy*; D001250:Asthma, Exercise-Induced / Q000628:therapy; D016535:Bronchial Hyperreactivity / Q000503:physiopathology; D002648:Child; D015444:Exercise; D006801:Humans; D007249:Inflammation / Q000503:physiopathology; D016210:Methacholine Chloride; D012129:Respiratory Function Tests; D012138:Respiratory Therapy
D016210:Methacholine Chloride