title: Association between obsessive-compulsive disorder and a variable number of tandem repeats polymorphism in intron 2 of the serotonin transporter gene.
abstract: BACKGROUND
  Pharmacological studies indicate a dysregulation of the serotonergic system in obsessive-compulsive disorder (OCD). A variable number tandem repeats (VNTR) polymorphism with three alleles (Stin2.9, Stin2.10, Stin2.12) has been described in intron 2 of the serotonin transporter (5-HTT) gene. This polymorphism has been associated with unipolar depression, bipolar disorder, schizophrenia, and anxiety disorders including OCD.
  
  
  METHODS
  The association between OCD and the polymorphism is examined in 97 OCD patients, 578 psychiatric controls and 406 healthy controls, all Spanish Caucasians.
  
  
  RESULTS
  Genotype frequencies for the polymorphism were significantly different in OCD patients, psychiatric patients and controls. There was a significant excess of 12/12 and 12/10 genotypes in OCD patients compared to psychiatric patients and controls.
  
  
  CONCLUSIONS
  Our results indicate a possible association between the Stin2.12 allele of the VNTR polymorphism and OCD.
authors.affiliation: Department of Psychiatry, Fundacion Jimenez Diaz Hospital, Avenida Reyes Catolicos 2, 28040, Madrid, Spain. ebacgar2@yahoo.es
authors.forename: Enrique
authors.initials: E
authors.lastname: Baca-Garcia
authors.forename: Concepcion
authors.initials: C
authors.lastname: Vaquero-Lorenzo
authors.forename: Montserrat
authors.initials: M
authors.lastname: Diaz-Hernandez
authors.forename: Beatriz
authors.initials: B
authors.lastname: Rodriguez-Salgado
authors.forename: Helen
authors.initials: H
authors.lastname: Dolengevich-Segal
authors.forename: Manuel
authors.initials: M
authors.lastname: Arrojo-Romero
authors.forename: Carlota
authors.initials: C
authors.lastname: Botillo-Martin
authors.forename: Antonio
authors.initials: A
authors.lastname: Ceverino
authors.forename: Jose Fernandez
authors.initials: JF
authors.lastname: Piqueras
authors.forename: M Mercedes
authors.initials: MM
authors.lastname: Perez-Rodriguez
authors.forename: Jeronimo
authors.initials: J
authors.lastname: Saiz-Ruiz
mesh_terms: D000483:Alleles; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D007438:Introns; D018598:Minisatellite Repeats / Q000235:genetics*; D009771:Obsessive-Compulsive Disorder / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*
chemical_list: D050486:Serotonin Plasma Membrane Transport Proteins