Regulation of immune tolerance by anti-inflammatory neuropeptides.
The induction of antigen-specific tolerance is essential to maintain immune homeostasis, control autoreactive T cells, prevent the onset of autoimmune diseases and achieve tolerance of transplants. Inflammation is a necessary process for eliminating pathogens, but can lead to serious deleterious effects in the host if left unchecked. Identifying the endogenous factors that control immune tolerance and inflammation is a key goal in the field of immunology. In the last decade, various neuropeptides that are produced by immune cells with potent anti-inflammatory actions were found to participate in the maintenance of tolerance in different immunological disorders.
Gonzalez-Rey
Elena
E
Instituto de Parasitología y Biomedicina, Consejo Superior de Investigaciones Cientificas, Avenida Conocimiento, Parque Tecnológico de Ciencias de la Salud, Granada 18100, Spain.
Chorny
Alejo
A
Delgado
Mario
M
D000818:Animals; D015551:Autoimmunity; D006801:Humans; D007108:Immune Tolerance; D007249:Inflammation / Q000276:immunology*; D018448:Models, Immunological; D009479:Neuropeptides / Q000276:immunology*; D015398:Signal Transduction / Q000276:immunology*
D009479:Neuropeptides