title: Membrane thickness design of implantable bio-MEMS sensors for the in-situ monitoring of blood flow.
abstract: This paper presents some ideas for the membrane thickness design of of implantable bio-micro-electro-mechanical systems (bio-MEMS) for the in situ monitoring of blood flow. The objective is to develop a smart wireless sensing unit for non-invasive early stenosis detection in heart bypass grafts. The design includes considerations of nonlinear material models, multiscale blood flows, and appropriate analyical models for data interpretation, as well as preliminary studies of the pressure and flow sensing concepts. The paper also examines the use of surface coatings for the design on biocompatibility and non-adhesion of blood platelets and constituents. The implications of the results are discussed for in vivo deployment of such sensor systems.
authors.affiliation: Department of Mechanical and Aerospace Engineering, Princeton University, Princeton, NJ 08544, USA.
authors.forename: C A
authors.initials: CA
authors.lastname: Steeves
authors.forename: Y L
authors.initials: YL
authors.lastname: Young
authors.forename: Z
authors.initials: Z
authors.lastname: Liu
authors.forename: A
authors.initials: A
authors.lastname: Bapat
authors.forename: K
authors.initials: K
authors.lastname: Bhalerao
authors.forename: A B O
authors.initials: AB
authors.lastname: Soboyejo
authors.forename: W O
authors.initials: WO
authors.lastname: Soboyejo
mesh_terms: D000818:Animals; D001698:Biomedical Engineering / Q000295:instrumentation / Q000379:methods; D015374:Biosensing Techniques / Q000295:instrumentation* / Q000379:methods; D001783:Blood Flow Velocity / Q000502:physiology*; D001792:Blood Platelets / Q000502:physiology; D001807:Blood Vessel Prosthesis; D002315:Cardiopulmonary Bypass; D002448:Cell Adhesion; D020099:Coated Materials, Biocompatible / Q000737:chemistry; D003251:Constriction, Pathologic / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control*; D004867:Equipment Design; D006801:Humans; D008422:Materials Testing; D008904:Miniaturization; D008954:Models, Biological; D008991:Monitoring, Physiologic; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013499:Surface Properties; D014160:Transducers, Pressure
chemical_list: D020099:Coated Materials, Biocompatible