Effect of GABAergic and adrenergic agents on activity of Na+/K+ pump and Cl(-)-cotransport in somatic muscle cells of earthworm Lumbricus Terrestris.
GABA, baclofen, epinephrine, and norepinephrine hyperpolarized the membrane of earthworm somatic cells. This effect was prevented by furosemide, removal of Cl- from the medium, or activation of Na+/K+ pump by 3-fold increase external potassium concentration. It was hypothesized that GABA, baclofen, epinephrine, and norepinephrine stimulate Na+/K+ transport via specific receptor inputs, but their effect on resting potential can be realized only under conditions of working Cl- symport.
Volkov
E M
EM
Kazan State Medical University. emvolkov@kzn.ru
Sabirova
A R
AR
Nurullin
L F
LF
Grishin
S N
SN
Zefirov
A L
AL
D018663:Adrenergic Agents / Q000494:pharmacology*; D000818:Animals; D018682:GABA Agents / Q000494:pharmacology*; D008564:Membrane Potentials / Q000187:drug effects*; D009132:Muscles / Q000187:drug effects* / Q000378:metabolism; D009835:Oligochaeta / Q000378:metabolism*; D049992:Sodium Chloride Symporters / Q000378:metabolism*; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*
D018663:Adrenergic Agents; D018682:GABA Agents; D049992:Sodium Chloride Symporters; D000254:Sodium-Potassium-Exchanging ATPase