title: Biocompatability of hydroxyapatite composite as a local drug delivery system.
abstract: OBJECTIVE
  To investigate the biocompatibility of hydroxyapatite composite (hydroxyapatite, plaster of Paris, and chitosan) impregnated with gentamicin, fosfomycin, imipenem, or amphotericin B.
  
  
  METHODS
  The interactions of the extract from each drug against osteoblast were tested using the methylthiotetrazole test.
  
  
  RESULTS
  Extracts from all drugs showed good biocompatibility at concentrations varying from 10 microgram/ml to 1000 microgram/ml. Imipenem and amphotericin B at a concentration of 1000 microgram/ml had a significantly higher percentage of cell viability than the control group. No morphological change of osteoblast was observed in all drug tests at any concentrations.
  
  
  CONCLUSIONS
  The hydroxyapatite composite had a good biocompatibility for carrying gentamicin, fosfomycin, imipenem, or amphotericin B.
authors.affiliation: Department of Orthopaedic and Physical Medicine, Faculty of Medicine, Prince of Songkla University, Haadyai, Songkhla, Thailand.
authors.forename: A
authors.initials: A
authors.lastname: Krisanapiboon
authors.forename: B
authors.initials: B
authors.lastname: Buranapanitkit
authors.forename: K
authors.initials: K
authors.lastname: Oungbho
mesh_terms: D000666:Amphotericin B / Q000008:administration & dosage; D001672:Biocompatible Materials; D002133:Calcium Sulfate; D048271:Chitosan; D016503:Drug Delivery Systems; D017886:Durapatite; D005578:Fosfomycin / Q000008:administration & dosage; D005839:Gentamicins / Q000008:administration & dosage; D006801:Humans; D015378:Imipenem / Q000008:administration & dosage; D010006:Osteoblasts / Q000187:drug effects
chemical_list: D001672:Biocompatible Materials; D005839:Gentamicins; D005578:Fosfomycin; D015378:Imipenem; D000666:Amphotericin B; D048271:Chitosan; D017886:Durapatite; D002133:Calcium Sulfate