title: The value of contrast enhanced ultrasonography in detection of liver metastases from colorectal cancer: a prospective double-blinded study.
abstract: OBJECTIVE
  To compare sensitivity and specificity of contrast enhanced ultrasonography (CEUS) with conventional ultrasonography (US) in detection of liver metastases in patients with colorectal adenocarcinoma (CRC) in a patient-by-patient analysis.
  
  
  METHODS
  A prospective study of 461 consecutive patients referred to the Department of Colorectal Surgery, Aarhus University Hospital with primary or local recurrence of CRC. In order to detect possible liver metastases all patients underwent liver US, followed by CEUS by another investigator. Multislice CT scanning (MDCT), and intraoperative ultrasonography (IOUS) were then performed. Fine-needle biopsy was performed on all suspicious lesions. Each examination was interpreted blindly and the combination of biphasic MDCT, IOUS, follow up and biopsy was the gold standard.
  
  
  RESULTS
  Standard of reference found liver metastases in 54 patients (14.8%). Contrast enhanced ultrasonography improved the sensitivity significantly in detection of liver metastases from 0.69 by US to 0.80 (p=0.031). In 24 patients, CEUS found a higher number of metastases than US (p<0.001). The specificity (0.98) and the positive predictive value (0.86) was the same.
  
  
  CONCLUSIONS
  Contrast enhanced ultrasonography improves sensitivity in detection of liver metastases in patients with CRC and in nearly half of the cases CEUS found a higher number of metastases than US.
authors.affiliation: Department of Radiology, Aarhus University Hospital, Tage Hansensgade 2, 8000 C, Aarhus, Denmark. ovl02ll@as.aaa.dk
authors.forename: Lars Peter Skovgaard
authors.initials: LP
authors.lastname: Larsen
authors.forename: Mona
authors.initials: M
authors.lastname: Rosenkilde
authors.forename: Henrik
authors.initials: H
authors.lastname: Christensen
authors.forename: Niels
authors.initials: N
authors.lastname: Bang
authors.forename: Lars
authors.initials: L
authors.lastname: Bolvig
authors.forename: Thomas
authors.initials: T
authors.lastname: Christiansen
authors.forename: Søren
authors.initials: S
authors.lastname: Laurberg
mesh_terms: D000230:Adenocarcinoma / Q000000981:diagnostic imaging* / Q000556:secondary*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044963:Biopsy, Fine-Needle; D015179:Colorectal Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D003287:Contrast Media; D004311:Double-Blind Method; D005188:False Negative Reactions; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007089:Image Enhancement; D007432:Intraoperative Period; D008113:Liver Neoplasms / Q000000981:diagnostic imaging* / Q000556:secondary*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D011446:Prospective Studies; D012107:Research Design; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed; D018084:Ultrasonography, Interventional / Q000379:methods
chemical_list: D003287:Contrast Media