Heterotopic ossification in skeletal muscle metastasis from colonic adenocarcinoma--a case report.
Colonic adenocarcinoma metastasising to the skeletal muscle is rare. A-56-yr-old Malay man was diagnosed to have adenocarcinoma of the right colon [Dukes B] for which a right hemicolectomy was performed, followed by radiotherapy and chemotherapy. Five years later the patient presented with a mass in the rectus abdominis muscle. The serum carcinoembryonic antigen was 71 ng/Ml. The mass was resected. Gross and microscopical examination showed multiple deposits of mucin-secreting adenocarcinoma with prominent heterotopic ossification in the stroma. The exact pathogenesis and significance of heterotopic ossification is not clear, but bone morphogenetic proteins may play an important role.
Naik
Venkatesh R
VR
Department of Pathology, School of Medical Sciences, Universiti Sains Malaysia. venkatesh@kb.usm.my
Jaafar
Hasnan
H
Mutum
Samarendra S
SS
D000230:Adenocarcinoma / Q000556:secondary*; D003110:Colonic Neoplasms / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000473:pathology*; D009999:Ossification, Heterotopic / Q000473:pathology*