title: Co-occurrence of affective and schizophrenia spectrum disorders with PINK1 mutations.
abstract: OBJECTIVE
  To investigate a possible association of mutations in the PTEN-induced putative kinase 1 (PINK1) gene with psychiatric disorders in a large family with monogenic parkinsonism.
  
  
  METHODS
  20 members of a family (4 homozygous, 11 heterozygous and 5 non-mutation carriers) were investigated for the presence of psychiatric disorders using the structured clinical interview for Diagnostic and Statistical Manual of Mental Disorders, 4th edition (DSM-IV); information on three additional heterozygous mutation carriers was obtained according to the family history research diagnostic criteria.
  
  
  RESULTS
  We found predominantly affective and schizophrenia spectrum disorders in 11 (61%) of the 18 mutation carriers and in 1 (20%) of the 5 mutation-negative cases.
  
  
  CONCLUSIONS
  First, affective and psychotic symptoms may be part of the phenotypic spectrum or even the sole manifestation of PINK1 mutations. Second, patients with familial movement disorders associated with psychiatric conditions may serve as a valuable study population to explore (genetic) causes of neuropsychiatric disease.
authors.affiliation: Department of Psychiatry and Psychotherapy, University of Lübeck, Ratzeburger Allee 160, D-23538 Lübeck, Germany.
authors.forename: Susanne
authors.initials: S
authors.lastname: Steinlechner
authors.forename: Jessica
authors.initials: J
authors.lastname: Stahlberg
authors.forename: Birgit
authors.initials: B
authors.lastname: Völkel
authors.forename: Ana
authors.initials: A
authors.lastname: Djarmati
authors.forename: Johann
authors.initials: J
authors.lastname: Hagenah
authors.forename: Anja
authors.initials: A
authors.lastname: Hiller
authors.forename: Katja
authors.initials: K
authors.lastname: Hedrich
authors.forename: Inke
authors.initials: I
authors.lastname: König
authors.forename: Christine
authors.initials: C
authors.lastname: Klein
authors.forename: Rebekka
authors.initials: R
authors.lastname: Lencer
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019964:Mood Disorders / Q000235:genetics*; D009154:Mutation; D020734:Parkinsonian Disorders / Q000235:genetics / Q000523:psychology; D010375:Pedigree; D011494:Protein Kinases / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics*; D000099202:PTEN-Induced Putative Kinase
chemical_list: D011494:Protein Kinases; D000099202:PTEN-Induced Putative Kinase