Xenofuranones A and B: phenylpyruvate dimers from Xenorhabdus szentirmaii.
Xenofuranones A (1) and B (2) have been isolated from cultures of the insect-pathogenic bacterium Xenorhabdus szentirmaii, and their structures were elucidated by NMR and mass spectroscopy. Both compounds show similarities to fungal furanones, and their biosynthesis was studied using a reversed approach by feeding putative 12C precursors to an overall 13C background in small-scale experiments followed by gas chromatographic analysis coupled to mass spectrometry.
Brachmann
Alexander O
AO
Pharmazeutische Biotechnologie, Universität des Saarlandes, P.O. Box 151150, D-66041 Saarbrücken, Germany.
Forst
Steven
S
Furgani
Ghazala M
GM
Fodor
Andras
A
Bode
Helge B
HB
D000818:Animals; D005247:Feeding Behavior / Q000187:drug effects; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007313:Insecta / Q000187:drug effects; D051379:Mice; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010667:Phenylpyruvic Acids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D020593:Xenorhabdus / Q000737:chemistry* / Q000472:pathogenicity
D005663:Furans; D010667:Phenylpyruvic Acids; C516375:xenofuranone A; C516376:xenofuranone B