Acute Myelogeneous Leukemia (M0/M1) with novel chromosomal abnormality of t(14;17) (q32; q11.2).
Acute Myelogeneous Leukemia (AML) is a heterogeneous disease with respect to morphology, immunophenotype, and genetic rearrangements. Multiple recurrent chromosomal aberrations have been identified by conventional cytogenetic analysis. In this study, we report a case whose clinical features were suggestive of AML-M1 subtype with t(14;17) (q32; q11.2) karyotype involving rearrangement of chromosomal segments 17q11.2 and 14q32. This is the first report of novel chromosomal translocation in this subset of AML and has not yet been reported elsewhere. This rearrangement may include certain cancer associated oncogene(s) or genes involved in the differentiation like retionic acid receptor alpha (RARA), which may confer differentiation blockage and/or proliferation advantage.
Ahmad
Firoz
F
Cancer Cytogenetic Division, SRL Ranbaxy Limited, MIDC, Mumbai, India.
Dalvi
Rupa
R
Mandava
Swarna
S
Das
Bibhu Ranjan
BR
D000328:Adult; D002883:Chromosomes, Human, Pair 14 / Q000235:genetics*; D002886:Chromosomes, Human, Pair 17 / Q000235:genetics*; D005260:Female; D006801:Humans; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000235:genetics* / Q000473:pathology; D014178:Translocation, Genetic / Q000235:genetics*