Outcome of pregnancy in patients with systemic lupus erythematosus.
OBJECTIVE
To study the maternal and fetal outcomes in women with systemic lupus erythematosus (SLE).


METHODS
Over a period of 10 years, 24 pregnancies in 17 females with SLE in a single center were enrolled. Fetal and maternal outcomes were studied retrospectively.


RESULTS
The mean patient age was 27.7 years. Twenty-one of the 24 pregnancies occurred in the period of disease remission at the time of conception. Proteinuria presented in 12 pregnancies; however, no patient developed acute renal failure or deterioration of renal function. There were three cases of preeclampsia in this study. Two patients had their disease flare up and delivered stillborns. One woman with secondary antiphospholipid syndrome (APS) had a fetal loss. There was no maternal mortality. The mean gestation age was 34.3 weeks (range, 17-41 weeks), and the mean birth weight was 2,179 g. The mean APGAR scores were 8 and 9 at 1 and 5 minutes, respectively. One baby with congenital atrioventricular block was born to a mother with positive anti-SSA antibody. There were five cases (20.8%) of intrauterine growth retardation and 10 preterm deliveries (41.6%) in this study.


CONCLUSIONS
Pregnancy is relatively safe in women with SLE in remission but should be considered as a high-risk pregnancy. APS is associated with poor pregnancy outcome. The patient needs to cooperate with obstetricians and physicians for optimal disease control and detailed monitoring throughout the gestation.
Wong
Chiong-Hee
CH
Department of Rheumatology, Mackay Memorial Hospital, Taipei, Taiwan.
Chen
Tien-Ling
TL
Lee
Chyou-Shen
CS
Lin
Chen-Ju
CJ
Chen
Chih-Ping
CP
D000328:Adult; D004305:Dose-Response Relationship, Drug; D005260:Female; D005306:Fertilization; D005938:Glucocorticoids / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000188:drug therapy / Q000503:physiopathology* / Q000652:urine; D011239:Prednisolone / Q000008:administration & dosage / Q000627:therapeutic use; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy / Q000503:physiopathology*; D011256:Pregnancy Outcome; D012074:Remission Induction; D012189:Retrospective Studies; D013997:Time Factors
D005938:Glucocorticoids; D011239:Prednisolone