Three new immunomodulating C21-steroidal glycosides from the stems of Stephanotis mucronata.
Three new C(21)-steroidal glycosides stemucronatosides H, I, and J (1-3, resp.) were isolated from the stems of Stephanotis mucronata, together with three known compounds sinomarinoside A (4), sinomarinoside E (5), and stephanoside H (6). These isolated compounds were tested for their immunological activities in vitro against concanavalin-A(Con A)- and lipopolysaccharide(LPS)-induced proliferation of mice splenocytes. Compounds 3, 4, and 6 showed immunosuppressive activities in a dose-dependent manner, while compounds 1, 2, and 5 possessed immunoenhancing activities.
Li
Xiaoyu
X
Department of Chemistry, Zhejiang University, Hangzhou 310027, PR China.
Sun
Hongxiang
H
Ye
Yiping
Y
Chen
Fengyang
F
Tu
Jue
J
Pan
Yuanjiang
Y
D000818:Animals; D002478:Cells, Cultured; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007155:Immunologic Factors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D051379:Mice; D010840:Phytosterols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018547:Plant Stems; D013154:Spleen / Q000166:cytology / Q000187:drug effects
D006027:Glycosides; D007155:Immunologic Factors; D010840:Phytosterols; D010936:Plant Extracts