title: Calculated microdosimetric characteristics of 125I and 103Pd brachytherapy seeds at different depths in water.
abstract: Both (125)I and (103)Pd sources have been widely used in the permanent prostate implant. An important consideration for the choice of brachytherapy sources is the relative biological effectiveness (RBE) for the source/seed used in the implantation. As RBE is closely related to the microdosimetric parameter, it is desirable to calculate the dose mean lineal energies for both (125)I and (103)Pd at various radial distances to the seed surface. Monte Carlo simulation was performed for photons emitted from (125)I and (103)Pd. Energy depositions from photons and all their secondary electrons were tracked. Dose distributions of lineal energy, d(y), were calculated for spheres of 1 microm in diameter and at various radial distances to the seed surface. From the dose distribution of lineal energy, the dose mean lineal energy, y(D), was derived. The results showed that the radiation qualities are constant in the distance range from 0.5 to 5 cm. In this distance range, the quality factor, relative to gamma rays from (60)Co, is 2.2 for (125)I and 2.5 for (103)Pd.
authors.affiliation: Department of Radiation Oncology, Columbia University, New York, NY 10032, USA. csw6@columbia.edu
authors.forename: Cheng-Shie
authors.initials: CS
authors.lastname: Wuu
authors.forename: Jing
authors.initials: J
authors.lastname: Chen
mesh_terms: D001918:Brachytherapy / Q000295:instrumentation / Q000379:methods*; D003198:Computer Simulation; D007457:Iodine Radioisotopes / Q000032:analysis* / Q000627:therapeutic use; D008954:Models, Biological; D010165:Palladium / Q000032:analysis* / Q000627:therapeutic use; D011868:Radioisotopes / Q000032:analysis* / Q000627:therapeutic use; D011874:Radiometry / Q000379:methods*; D011879:Radiotherapy Dosage; D014867:Water / Q000737:chemistry*
chemical_list: D007457:Iodine Radioisotopes; D011868:Radioisotopes; D014867:Water; D010165:Palladium