Effects of chronic stress on the immune response to oral human serum albumin-conjugated starch microparticles in rats.
Uptake of antigens and bacteria over the follicle-associated epithelium (FAE) is increased after chronic psychological stress. We investigated whether stress affects the immune response to particle-conjugated antigens taken up via the FAE. Rats were submitted to two 10-day periods of water avoidance stress and orally immunized during these periods. Stressed immunized rats displayed altered cell populations and a Th1-skewed immune response within the lymphoid follicles, together with enhanced delayed-type hypersensitivity. We conclude that chronic stress affects the cell-mediated immune response after oral immunization, which may have implications for the understanding of allergic and autoimmune diseases and development of oral vaccines.
Keita
Asa V
AV
Department of Biomedicine and Surgery, Division of Surgery, Faculty of Health Sciences, Linköping University, Sweden.
Stertman
Linda
L
Sun
Yi-Qian
YQ
Larhed
Agneta
A
Sjöholm
Ingvar
I
Söderholm
Johan D
JD
D000284:Administration, Oral; D000818:Animals; D000943:Antigens, Differentiation / Q000378:metabolism; D016827:CD8 Antigens / Q000378:metabolism; D002908:Chronic Disease; D016207:Cytokines / Q000378:metabolism; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D005434:Flow Cytometry / Q000379:methods; D005786:Gene Expression Regulation / Q000502:physiology; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000209:etiology / Q000276:immunology; D008297:Male; D010581:Peyer's Patches / Q000276:immunology / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012709:Serum Albumin / Q000008:administration & dosage / Q000276:immunology*; D013213:Starch / Q000008:administration & dosage* / Q000276:immunology; D013315:Stress, Psychological / Q000276:immunology* / Q000473:pathology; D013997:Time Factors
D000943:Antigens, Differentiation; D016827:CD8 Antigens; D016207:Cytokines; C459465:OX-62 antigen, rat; D012709:Serum Albumin; D013213:Starch