title: Seroprevalence of anti-Kudoa sp. (Myxosporea: Multivalvulida) antibodies in a Spanish population.
abstract: A majority of Kudoa species infect the somatic muscle of fish establishing cysts. Because there is no effective method to detect infected fish without destroying them, these parasitised fish reach the consumer. The elevated humoral responses detected previously by us in BALB/c mice immunised with Kudoa sp. pseudocyst extracts and the high IgG1 and IgE levels induced by the oral administration of Kudoa pseudocysts to BALB/c mice showed the possible immunopathological effects in man from the ingestion of Kudoa-infected fish. In this work, we investigated the seroprevalence of anti-Kudoa sp. antibodies in a Spanish healthy population and the possible association between the manifestation of allergic reactions after fish consumption and the humoral responses to Kudoa sp. antigens. Specific anti-Kudoa sp. antibody levels in sera of patients diagnosed with several digestive pathologies were also determined, studying their possible association with the alteration of analytic parameters in these patients.
authors.affiliation: Departamento de Parasitología, Facultad de Farmacia, Universidad Complutense, Plaza de Ramón y Cajal s/n, 28040 Madrid, Spain.
authors.forename: Gonzalo
authors.initials: G
authors.lastname: Martínez de Velasco
authors.forename: Marta
authors.initials: M
authors.lastname: Rodero
authors.forename: Tomás
authors.initials: T
authors.lastname: Chivato
authors.forename: Carmen
authors.initials: C
authors.lastname: Cuéllar
mesh_terms: D000328:Adult; D000818:Animals; D000913:Antibodies, Protozoan / Q000097:blood* / Q000276:immunology; D056890:Eukaryota / Q000276:immunology / Q000502:physiology*; D005399:Fishes / Q000469:parasitology*; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology; D013030:Spain
chemical_list: D000913:Antibodies, Protozoan