title: Binding properties of aromatic carbon-bound fluorine.
abstract: A systematic computational analysis of the ability of aromatic carbon-bound fluorine to participate in hydrogen bonding and electrostatic interactions has been completed. The interaction energies between the most common fluoroaromatics used in medicinal chemistry and both water, the prototypical hydrogen bond donor, and several cations have been calculated at different levels of theory (HF, MP2, DFT). Our results show that aromatic fluorine can participate in significant hydrogen bonds and can also interact with charged molecules.
authors.affiliation: Department of Chemistry and School of Pharmacy, University of Wisconsin, 777 Highland Avenue, Madison, WI 53705, USA.
authors.forename: Andrew V
authors.initials: AV
authors.lastname: Razgulin
authors.forename: Sandro
authors.initials: S
authors.lastname: Mecozzi
mesh_terms: D002244:Carbon / Q000737:chemistry* / Q000378:metabolism; D005461:Fluorine / Q000737:chemistry / Q000378:metabolism*; D006860:Hydrogen Bonding; D008956:Models, Chemical; D008958:Models, Molecular; D015394:Molecular Structure; D055672:Static Electricity; D014867:Water / Q000737:chemistry / Q000378:metabolism*
chemical_list: D014867:Water; D005461:Fluorine; D002244:Carbon