Keeping the noise down in ES cells.
A new report (Szutorisz et al., 2006) suggests that embryonic stem (ES) cells adopt an unusual strategy to remain perpetually poised for differentiation. Apparently, ES cells use the proteasome to target transcriptional preinitiation complexes, thus minimizing transcriptional noise at genes that promote differentiation.
Zwaka
Thomas P
TP
Baylor College of Medicine, Department of Molecular and Cellular Biology and Center for Cell and Gene Therapy, One Baylor Plaza, Houston, TX 77030, USA. tpzwaka@bcm.edu
D000818:Animals; D002454:Cell Differentiation; D021901:DNA, Intergenic / Q000235:genetics / Q000378:metabolism; D053595:Embryonic Stem Cells / Q000502:physiology*; D051379:Mice; D008954:Models, Biological; D046988:Proteasome Endopeptidase Complex / Q000235:genetics* / Q000378:metabolism / Q000502:physiology; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*; D014158:Transcription, Genetic
D021901:DNA, Intergenic; D014157:Transcription Factors; D046988:Proteasome Endopeptidase Complex