title: [Peripheral T-cell lymphoma presenting with eosinophilia due to interleukin-5 produced by lymphoma cells].
abstract: A 72-year-old male was admitted to our hospital to determine the cause of neck lymphadenopathies. He was diagnosed pathologically by a lymph node biopsy as having peripheral T-cell lymphoma (PTCL). He also had developed eosinophilia and his serum concentration of Interleukin-5 (IL-5) was extremely high. Immunostaining of a resected lymph node revealed that there were lymphoma cells which were stained with anti-IL-5 antibody. After 2 courses of CHOP therapy, the lymphadenopathies and eosinophilia disappeared and the concentration of serum IL-5 was normalized. It was suggested that IL-5 produced by lymphoma cells had induced his eosinophilia.
authors.affiliation: Fourth Department of Internal Medicine, Sapporo Medical University, School of Medicine.
authors.forename: Takuya
authors.initials: T
authors.lastname: Matsunaga
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Sato
authors.forename: Satoshi
authors.initials: S
authors.lastname: Iyama
authors.forename: Shingo
authors.initials: S
authors.lastname: Tanaka
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Murase
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Sato
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Kobune
authors.forename: Rishu
authors.initials: R
authors.lastname: Takimoto
authors.forename: Junji
authors.initials: J
authors.lastname: Kato
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kuroda
authors.forename: Yoshiro
authors.initials: Y
authors.lastname: Niitsu
mesh_terms: D000368:Aged; D004802:Eosinophilia / Q000209:etiology*; D006801:Humans; D015848:Interleukin-5 / Q000096:biosynthesis*; D016411:Lymphoma, T-Cell, Peripheral / Q000150:complications / Q000378:metabolism*; D008297:Male
chemical_list: D015848:Interleukin-5