title: Polymorphisms of DNA repair genes are risk factors for prostate cancer.
abstract: DNA repair gene alterations have been shown to cause a reduction in DNA repair capacity. We hypothesised that DNA repair gene polymorphisms may be risk factors for prostate cancer (PC). To test this hypothesis, DNA samples from 165 cases of prostate cancer and healthy controls were analyzed by PCR-RFLP to determine the genotypic frequency of three DNA repair genes (XRCC1, XPC and XRCC7). We found that the frequency of 939Gln variant at XPC Lys939Gln was significantly lower in PC cases (OR=0.39, P=0.016). Haplotype analysis of XRCC1 Arg194Trp (C/T) and Arg399Gln (G/A) revealed that the frequency of the T-A haplotype was significantly higher in PC patients. This is the first report on the studies of XPC and XRCC1 Arg194Trp polymorphisms in PC, and our present data suggest that XPC Lys939Gln and the T-A haplotype of XRCC1 Arg194Trp and Arg399Gln may be risk factors for PC in Japanese.
authors.affiliation: Department of Urology, Veterans Affairs Medical Center and University of California at San Francisco, 4150 Clement Street, San Francisco, CA 94121, United States.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Hirata
authors.forename: Yuji
authors.initials: Y
authors.lastname: Hinoda
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Tanaka
authors.forename: Naoko
authors.initials: N
authors.lastname: Okayama
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Suehiro
authors.forename: Ken
authors.initials: K
authors.lastname: Kawamoto
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Kikuno
authors.forename: Shahana
authors.initials: S
authors.lastname: Majid
authors.forename: Kaveh
authors.initials: K
authors.lastname: Vejdani
authors.forename: Rajvir
authors.initials: R
authors.lastname: Dahiya
mesh_terms: D000368:Aged; D004260:DNA Repair / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D008297:Male; D016133:Polymerase Chain Reaction / Q000379:methods; D011110:Polymorphism, Genetic / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length; D011471:Prostatic Neoplasms / Q000235:genetics*; D012307:Risk Factors; D000076105:X-ray Repair Cross Complementing Protein 1
chemical_list: D004268:DNA-Binding Proteins; D000076105:X-ray Repair Cross Complementing Protein 1; C000619371:XRCC1 protein, human