title: Two new taxanes from the needles and branches bark of Taxus cuspidata.
abstract: Two new taxanes were isolated from the MeOH extract of the needles and branches bark of the Japanese yew, Taxus cuspidata. The structures were established as (2alpha,5alpha,7beta,9alpha,10beta,13alpha)-5,10,13,20-tetraacetoxytax-11-ene-2,7,9-triol (1) and (2alpha,5alpha,9alpha,10beta)-2,9,10-triacetoxy-5-[(beta-D-glucopyranosyl)oxy]-3,11-cyclotax-11-en-13-one (2) on the basis of in-depth 1D- and 2D-NMR analyses. Compound 2 is the first example of a transannular taxane glycoside isolated from a natural source.
authors.affiliation: Laboratory of Medicinal Natural Product Chemistry, School of Pharmaceutical Sciences, Hebei Medicinal University, 361 Zhongshan East Road, 050017, Shijiazhuang, Hebei Province, P.R. China.
authors.forename: Cong-Mei
authors.initials: CM
authors.lastname: Cao
authors.forename: Man-Li
authors.initials: ML
authors.lastname: Zhang
authors.forename: Yu-Fang
authors.initials: YF
authors.lastname: Wang
authors.forename: Qing-Wen
authors.initials: QW
authors.lastname: Shi
authors.forename: Teiko
authors.initials: T
authors.lastname: Yamada
authors.forename: Hiromasa
authors.initials: H
authors.lastname: Kiyota
mesh_terms: D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D024301:Plant Bark / Q000737:chemistry; D018515:Plant Leaves / Q000737:chemistry; D043823:Taxoids / Q000737:chemistry / Q000302:isolation & purification*; D020946:Taxus / Q000737:chemistry*
chemical_list: C517475:(2alpha,5alpha,7beta,9alpha,10beta,13alpha)-5,10,13,20-tetraacetoxytax-11-ene-2,7,9-triol; C517474:(2alpha,5alpha,9alpha,10beta)-2,9,10-triacetoxy-5-((beta-D-glucopyranosyl)oxy)-3,11-cyclotax-11-en-13-one; D043823:Taxoids