HLA-DQA is associated with abdominal aortic aneurysms in the Belgian population.
Chronic inflammation and autoimmunity likely contribute to the pathogenesis of abdominal aortic aneurysms (AAAs). The aim of this study was to investigate the role of autoimmunity in the etiology of AAAs using a genetic association study approach with human leukocyte antigen (HLA) polymorphisms (HLA-DQA1, -DQB1, -DRB1 and -DRB3-5 alleles) in 387 AAA cases and 426 controls. We observed an association with the HLA-DQA1 locus among Belgian males, and found a significant difference in the HLA-DQA1*0102 allele frequencies between AAA cases and controls. In conclusion, this study showed potential evidence that the HLA-DQA1 locus harbors a genetic risk factor for AAAs suggesting that autoimmunity plays a role in the pathogenesis of AAAs.
Tromp
Gerard
G
Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, 3317 Gordon H. Scott Hall of Basic Medical Sciences, 540 E. Canfield Ave., Detroit, MI 48201, USA.
Ogata
Toru
T
Gregoire
Lucie
L
Goddard
Katrina A B
KA
Skunca
Magdalena
M
Lancaster
Wayne D
WD
Parrado
Antonio R
AR
Lu
Qing
Q
Shibamura
Hidenori
H
Sakalihasan
Natzi
N
Limet
Raymond
R
Mackean
Gerald L
GL
Arthur
Claudette
C
Sueda
Taijiro
T
Kuivaniemi
Helena
H
D000483:Alleles; D017544:Aortic Aneurysm, Abdominal / Q000235:genetics*; D001530:Belgium; D006683:HLA-DQ Antigens / Q000235:genetics*; D059848:HLA-DQ alpha-Chains; D006801:Humans; D011153:Population; D012307:Risk Factors
D006683:HLA-DQ Antigens; D059848:HLA-DQ alpha-Chains; C069050:HLA-DQA1 antigen