Association of G72/G30 polymorphisms with early-onset and male schizophrenia.
To explore the effect of G72/G30 polymorphisms on the clinical manifestations of schizophrenia, especially on the age at onset and sex of patients, we examined three single nucleotide polymorphisms in 216 schizophrenic patients and 321 healthy controls. Significant associations of schizophrenia with the A allele of rs947267 (P=0.012) and haplotype A-A-G (rs2391191-rs947267-rs778294) (P=0.008) were found in early-onset schizophrenic patients. So did the same allele (P=0.034) and haplotype (P=0.009) as mentioned above in male patients. These findings suggest that the G72/G30 gene may modulate the age at onset and there might be a potential interaction between this locus and sex in the pathogenesis of schizophrenia.
Yue
Weihua
W
Institute of Mental Health, Peking University, Peking, Beijing, China.
Liu
Zhonghua
Z
Kang
Guolian
G
Yan
Jun
J
Tang
Fulei
F
Ruan
Yan
Y
Zhang
Jifeng
J
Zhang
Dai
D
D000328:Adult; D017668:Age of Onset; D002352:Carrier Proteins / Q000235:genetics*; D016001:Confidence Intervals; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D008297:Male; D016017:Odds Ratio; D011110:Polymorphism, Genetic / Q000235:genetics*; D011506:Proteins / Q000235:genetics*; D012333:RNA, Messenger / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction / Q000379:methods; D012559:Schizophrenia / Q000235:genetics*; D012727:Sex Characteristics
D002352:Carrier Proteins; C475071:DAOA protein, human; C488199:DAOAAS gene product, human; D047908:Intracellular Signaling Peptides and Proteins; D011506:Proteins; D012333:RNA, Messenger