Temporal discontiguity is neither necessary nor sufficient for learning-induced effects on adult neurogenesis.
Some, but not all, types of learning and memory can influence neurogenesis in the adult hippocampus. Trace eyeblink conditioning has been shown to enhance the survival of new neurons, whereas delay eyeblink conditioning has no such effect. The key difference between the two training procedures is that the conditioning stimuli are separated in time during trace but not delay conditioning. These findings raise the question of whether temporal discontiguity is necessary for enhancing the survival of new neurons. Here we used two approaches to test this hypothesis. First, we examined the influence of a delay conditioning task in which the duration of the conditioned stimulus (CS) was increased nearly twofold, a procedure that critically engages the hippocampus. Although the CS and unconditioned stimulus are contiguous, this very long delay conditioning procedure increased the number of new neurons that survived. Second, we examined the influence of learning the trace conditioned response (CR) after having acquired the CR during delay conditioning, a procedure that renders trace conditioning hippocampal-independent. In this case, trace conditioning did not enhance the survival of new neurons. Together, these results demonstrate that associative learning increases the survival of new neurons in the adult hippocampus, regardless of temporal contiguity.
Leuner
Benedetta
B
Department of Psychology, Princeton University, Princeton, New Jersey 08544, USA.
Waddell
Jaylyn
J
Gould
Elizabeth
E
Shors
Tracey J
TJ
D000818:Animals; D002470:Cell Survival / Q000502:physiology; D003215:Conditioning, Eyelid / Q000502:physiology; D003213:Conditioning, Psychological / Q000502:physiology; D006624:Hippocampus / Q000166:cytology / Q000502:physiology; D007858:Learning / Q000502:physiology*; D008297:Male; D009474:Neurons / Q000166:cytology* / Q000502:physiology*; D011597:Psychomotor Performance / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors