[Microbial nucleic acids in the pathogenesis of glomerulonephritis].
Recent advances in the understanding of innate pathogen recognition revealed that nucleic acids have immunomodulatory functions in inflammation. A set of Toll-like pattern-recognition receptors recognize various types of microbial nucleic acids, i.e. double-stranded viral RNA (TLR3), single-stranded viral RNA (TLR7 and TLR8), and viral and bacterial CpG-DNA (TLR9). All of these TLRs are differentially expressed in the healthy and diseased kidney and TLR ligation was shown to initiate and modulate experimental glomerulonephritis. In this review we summarize the arising evidence in this field and discuss new hypotheses for the pathogenesis of kidney diseases that are triggered by infectious organisms.
Anders
Hans-Joachim
HJ
Service de Néphrologie, Polyclinique Médicale, Université de Munich, Allemagne.
Zecher
Daniel
D
Schlöndorff
Detlef
D
D001425:Bacterial Outer Membrane Proteins / Q000235:genetics / Q000302:isolation & purification; D004269:DNA, Bacterial / Q000302:isolation & purification; D004279:DNA, Viral / Q000302:isolation & purification; D005920:Glomerular Mesangium / Q000382:microbiology / Q000821:virology; D005921:Glomerulonephritis / Q000382:microbiology* / Q000821:virology; D006801:Humans; D012329:RNA, Bacterial / Q000302:isolation & purification; D012330:RNA, Double-Stranded / Q000235:genetics / Q000302:isolation & purification; D012367:RNA, Viral / Q000302:isolation & purification
D001425:Bacterial Outer Membrane Proteins; D004269:DNA, Bacterial; D004279:DNA, Viral; D012329:RNA, Bacterial; D012330:RNA, Double-Stranded; D012367:RNA, Viral; C419843:TLR protein, bacteria