title: Intramuscular olanzapine in patients with borderline personality disorder: an observational study in an emergency room.
abstract: OBJECTIVE
  Despite the frequency of borderline personality disorder (BPD) in patients with acute agitation in emergency departments (EDs), there are few data about the use of intramuscular (IM) psychotropics in those patients. This is the first open-label study with olanzapine in this setting.
  
  
  METHODS
  Measures were collected prospectively for patients with acute agitation in ED. Consent was obtained subsequently and diagnosis ascertained using the Structured Clinical Interview for DSM-IV. A group of 25 patients with severe agitation and BPD received olanzapine 10 mg IM. Efficacy and safety data are available at baseline, 2 h postinjection and at discharge.
  
  
  RESULTS
  Significant reductions of agitation associated with good tolerance were observed 2 h after the first IM olanzapine. Sixteen percent of patients required a second IM olanzapine.
  
  
  CONCLUSIONS
  Randomized, placebo-controlled studies are needed to confirm the efficacy of IM olanzapine in patients with acute agitation and BPD.
authors.affiliation: Service d'urgences psychiatriques, Centre Hospitalier Régional La Citadelle, 1 Boulevard du Douzième de Ligne, 4000 Liège, Belgium. c.damsa@bluewin.ch
authors.forename: Cristian
authors.initials: C
authors.lastname: Damsa
authors.forename: Eric
authors.initials: E
authors.lastname: Adam
authors.forename: François
authors.initials: F
authors.lastname: De Gregorio
authors.forename: Lionel
authors.initials: L
authors.lastname: Cailhol
authors.forename: Joseph
authors.initials: J
authors.lastname: Lejeune
authors.forename: Coralie
authors.initials: C
authors.lastname: Lazignac
authors.forename: Michael H
authors.initials: MH
authors.lastname: Allen
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001569:Benzodiazepines / Q000008:administration & dosage / Q000627:therapeutic use; D001883:Borderline Personality Disorder / Q000188:drug therapy*; D004637:Emergency Services, Psychiatric; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D008297:Male; D019370:Observation; D000077152:Olanzapine; D011446:Prospective Studies
chemical_list: D014150:Antipsychotic Agents; D001569:Benzodiazepines; D000077152:Olanzapine