Influence of transcranial magnetic stimulation on spike-wave discharges in a genetic model of absence epilepsy.
Transcranial magnetic stimulation (TMS) impulses, (0.5 Hz, 3 impulses) were presented at threshold intensity to male WAG/Rij rats. One group received stimuli, which involved motor responses of hindlimbs, rats of the second group received sham stimulation. Electrocorticograms (ECoG) were recorded before and up to 2 hr from the moment of transcranial magnetic stimulation. It was established that such stimulation engendered a reduction of spike-wave discharge (SWD) bursts duration. This effect was most pronounced in 30 min from the moment of cessation of stimulation, when a decrease of 31.4% was noted in comparison with sham-stimulated control group. The number of bursts of spike-wave discharges was reduced, but did not reach significant difference when compared both with pre-stimulative base-line level and with sham-stimulated control rats. Bursts of spike-wave discharges restored up to pre-stimulative level in 90-150 minutes from the moment of cessation of transcranial stimulation. It can be concluded that transcranical magnetic stimulation possessed an ability to engender short-time suppression of bursts of spike-wave discharges in WAG/Rij rats.
Godlevsky
Leonid S
LS
Department of Biophysics, Informatics and Medical Devices, Medical University, Odessa, Valehovsky Lane 2, Ukraine. godlevsky@odmu.od.ua
Kobolev
Evgeniy V
EV
van Luijtelaar
Egidius L J M
EL
Coenen
Antony M L
AM
Stepanenko
Konstantin I
KI
Smirnov
Igor V
IV
D000200:Action Potentials; D000818:Animals; D001522:Behavior, Animal; D004569:Electroencephalography; D004832:Epilepsy, Absence / Q000503:physiopathology*; D008280:Magnetics; D008297:Male; D051381:Rats