title: Formation of a new oxidative metabolite from kobophenol A by human intestinal bacterium Klebsiella pneumoniae.
abstract: During our studies on the metabolism of kobophenol A (1) in rats, we had isolated, purified, and identified the main new oxidative metabolite of 1, koboquinone A (2) from rats' feces. To elucidate the metabolic pathway of 1 in rats, we conducted the in vitro metabolic experiments of 1 by human intestinal bacteria and found that Klebsiella pneumoniae produced appreciable amounts of 2. This was verified by means of high performance liquid chromatography mass/mass spectrometry (HPLC/MS/MS) analysis.
authors.affiliation: Department of Chemistry of Natural Drugs, School of Pharmacy, Fudan University, Shanghai 200032, People's Republic of China. lianggl72@shmu.edu.cn
authors.forename: Gaolin
authors.initials: G
authors.lastname: Liang
authors.forename: Lisheng
authors.initials: L
authors.lastname: Qian
authors.forename: Yiling
authors.initials: Y
authors.lastname: Cui
authors.forename: Changqi
authors.initials: C
authors.lastname: Hu
mesh_terms: D016227:Benzoquinones / Q000737:chemistry / Q000378:metabolism*; D032602:Caragana / Q000737:chemistry; D041981:Gastrointestinal Tract / Q000382:microbiology; D006801:Humans; D007711:Klebsiella pneumoniae / Q000378:metabolism*; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry; D013267:Stilbenes / Q000737:chemistry / Q000378:metabolism*
chemical_list: D016227:Benzoquinones; D013267:Stilbenes; C510380:kobophenol A; C499874:koboquinone A