Feasibility and safety of granulocyte colony-stimulating factor treatment in patients with acute myocardial infarction.
BACKGROUND
This study examined feasibility and safety of granulocyte colony-stimulating factor (G-CSF) treatment for patients with acute myocardial infarction (AMI).


METHODS
Forty patients with AMI related with the left anterior descending coronary artery, who underwent successful percutaneous coronary intervention (PCI), were randomized into G-CSF group (n=18) or Control group (n=22). G-CSF treatment was started within 24 h after PCI. 99mTc-tetrofosmin single-photon emission computed tomography (SPECT) was performed at 4 days and 6 months after AMI. SPECT data was analyzed for LV end-diastolic volume (LVEDV), LV end-systolic volume (LVESV), LV ejection fraction (LVEF) and myocardial perfusion.


RESULTS
LVEF at 6 months was significantly better than that at 4 days in G-CSF group (p=0.013), but not changed in Control group (p=0.245). Although no significant difference was observed for LVEDV between the two groups, LVESV tended to be decreased only in G-CSF group. In G-CSF group, defect score (DS) was significantly decreased from 4 days to 6 months after AMI. Restenosis rate at 6 months after AMI was not significantly different between the two groups.


CONCLUSIONS
G-CSF treatment for patients with AMI was effective and did not have any clinical and angiographic adverse effects.
Takano
Hiroyuki
H
Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan.
Hasegawa
Hiroshi
H
Kuwabara
Yoichi
Y
Nakayama
Takashi
T
Matsuno
Koki
K
Miyazaki
Yoshiya
Y
Yamamoto
Masashi
M
Fujimoto
Yoshihide
Y
Okada
Hisayuki
H
Okubo
Shinji
S
Fujita
Miwa
M
Shindo
Satoshi
S
Kobayashi
Yoshio
Y
Komiyama
Nobuyuki
N
Takekoshi
Noboru
N
Imai
Kamon
K
Himi
Toshiharu
T
Ishibashi
Iwao
I
Komuro
Issei
I
D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D003131:Combined Modality Therapy; D005240:Feasibility Studies; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000000981:diagnostic imaging / Q000628:therapy*; D011446:Prospective Studies; D011859:Radiography; D011877:Radionuclide Imaging; D016037:Single-Blind Method; D016896:Treatment Outcome
D016179:Granulocyte Colony-Stimulating Factor