title: Outside looking in: the inner workings of the cross-presentation pathway within dendritic cells.
abstract: The entry of exogenous antigen into the MHC class I-restricted cross-presentation pathway can contribute to CD8(+) T cell tolerance and immunity, in particular to peripheral self-antigens or selected viruses and bacteria showing restricted tissue tropism. Dendritic cells are the key cross-presenting cells and, as such, they are thought to carry specialized machinery dedicated to this purpose. Two recent papers describe intracellular components tailored to the dendritic cell cross-presentation pathway.
authors.affiliation: Immunology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville 3050, Australia.
authors.forename: Jose A
authors.initials: JA
authors.lastname: Villadangos
authors.forename: William R
authors.initials: WR
authors.lastname: Heath
authors.forename: Francis R
authors.initials: FR
authors.lastname: Carbone
mesh_terms: D017951:Antigen Presentation / Q000276:immunology*; D045142:Cross-Priming / Q000276:immunology*; D003713:Dendritic Cells / Q000276:immunology*; D004721:Endoplasmic Reticulum / Q000276:immunology; D006863:Hydrogen-Ion Concentration; D015398:Signal Transduction / Q000276:immunology*