title: Endoscopic full-thickness closure of large gastric perforations by use of tissue anchors.
abstract: BACKGROUND
  A flexible needle-catheter tissue-anchoring device was developed to accomplish full-thickness tissue apposition of the GI wall. The aim of this study was to identify the performance of this device for repair of large iatrogenic gastric perforations in a porcine model.
  
  
  OBJECTIVE
  Six pigs.
  
  
  METHODS
  Short-term survival animal study.
  
  
  METHODS
  Pigs were studied while they were under general anesthesia. Device performance in differing gastric locations and wall thicknesses was assessed by 2 perforations more than 2 cm in size created for each pig along the greater curvature and the anterior wall.
  
  
  METHODS
  Each perforation was closed by parallel placement of tissue anchor sets sequentially along the length of the perforation.
  
  
  METHODS
  One week follow-up endoscopy and necropsy were performed.
  
  
  RESULTS
  Twelve perforations were closed with the 48 tissue anchor sets. All animals survived for 1 week without clinical complications. Follow-up endoscopy and necropsy revealed that all tissue anchors remained with firmly held sutures and sealed perforations.
  
  
  CONCLUSIONS
  Full-thickness closure with a new tissue-anchoring device simply and successfully repaired large iatrogenic gastric perforations.
authors.affiliation: Developmental Endoscopy Unit, Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA.
authors.forename: Kazuki
authors.initials: K
authors.lastname: Sumiyama
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Gostout
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Rajan
authors.forename: Timothy A
authors.initials: TA
authors.lastname: Bakken
authors.forename: Jodie L
authors.initials: JL
authors.lastname: Deters
authors.forename: Mary A
authors.initials: MA
authors.lastname: Knipschield
mesh_terms: D000818:Animals; D002404:Catheterization; D016099:Endoscopy, Gastrointestinal; D004867:Equipment Design; D023421:Models, Animal; D013272:Stomach Diseases / Q000601:surgery*; D013536:Suture Techniques / Q000295:instrumentation*; D013552:Swine