Intracellular changes in rat hepatocytes after intratracheal administration of highly dispersed silicon dioxide and uridine effects on these changes.
Rat hepatocytes were examined under electron microscope at early terms after intratracheal administration of highly dispersed silicon dioxide powder against the background of uridine treatment. Penetration of powder particles into hepatocyte cytoplasm, nuclei, mitochondria, and peroxisomes and development of bacteria in these cells were observed. Uridine reduced the destructive effect of powder on the organelles, increased glycogen content in hepatocytes, and inhibited the formation of capsulated bacterial forms in these cells.
Lebkova
N P
NP
Russian State Medical Academy of Postgraduate Education, Moscow.
Baranov
V I
VI
D000818:Animals; D022082:Cellular Structures / Q000187:drug effects* / Q000648:ultrastructure; D022781:Hepatocytes / Q000187:drug effects* / Q000648:ultrastructure*; D008854:Microscopy, Electron; D010316:Particle Size; D051381:Rats; D012822:Silicon Dioxide / Q000008:administration & dosage / Q000633:toxicity*; D014529:Uridine / Q000008:administration & dosage / Q000494:pharmacology*
D012822:Silicon Dioxide; D014529:Uridine