title: In vitro potentiation of antimalarial activities by daphnetin derivatives against Plasmodium falciparum.
abstract: OBJECTIVE
  To screen the antimalarial compounds of daphnetin derivatives against Plasmodium falciparum in vitro.
  
  
  METHODS
  Plasmodium faciparum (FCC1) was cultured in vitro by a modified method of Trager and Jensen. Antimalarial compounds were screened by microscopy-based assay and microfluorimetric method.
  
  
  RESULTS
  DA79 and DA78 showed potent antimalarial activity against Plasmodium falciparum cultured in vitro.
  
  
  CONCLUSIONS
  Though the relationship between the structures of daphnetin derivatives and their antimalarial activities has not been clarified yet, this study may provide a new direction for discovery of more potential antimalarial compounds.
authors.affiliation: National Institute of Parasite Diseases, Chinese Center for Disease Control and Prevention, Shanghai 200025, China. huangfang78@yahoo.com.cn
authors.forename: Fang
authors.initials: F
authors.lastname: Huang
authors.forename: Lin-Hua
authors.initials: LH
authors.lastname: Tang
authors.forename: Lin-Qian
authors.initials: LQ
authors.lastname: Yu
authors.forename: Yi-Chang
authors.initials: YC
authors.lastname: Ni
authors.forename: Qin-Mei
authors.initials: QM
authors.lastname: Wang
authors.forename: Fa-Jun
authors.initials: FJ
authors.lastname: Nan
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000493:pharmacokinetics* / Q000494:pharmacology; D010963:Plasmodium falciparum / Q000187:drug effects*; D014468:Umbelliferones / Q000737:chemistry / Q000493:pharmacokinetics* / Q000494:pharmacology
chemical_list: D000962:Antimalarials; D014468:Umbelliferones; C039952:daphnetin