[Chemoradiation therapy in conjunction with physical means of radiomodification for locally advanced laryngeal cancer].
The study deals with the results of examination and treatment of 1040 patients with cancer (T3-4N0-3M0) of larynx and laryngopharynx. Radiotherapy was given to 358 patients concurrently with systemic polychemotherapy and different means of radiomodification. The remaining patients (682) receiving the same treatment minus systemic polychemotherapy were in control. Relapse-free (72.6%) and overall survival (82.7%) in the study group was significantly higher than in controls (54.7% and 63.4%, respectively) (p < 0.001). Moreover, an organ's function was preserved in 57.1% compared with 28.5% in control (p < 0.001).
Pankratov
V A
VA
Andreev
V G
VG
Rozhov
V A
VA
Gulibov
I A
IA
Baryshev
V V
VV
Buiakova
M E
ME
Vdovina
S N
SN
Kurpeshev
O K
OK
Podlesnykh
N I
NI
Litovkina
L V
LV
D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology / Q000532:radiotherapy*; D008297:Male; D008875:Middle Aged; D010610:Pharyngeal Neoplasms / Q000188:drug therapy* / Q000503:physiopathology / Q000532:radiotherapy* / Q000556:secondary; D011788:Quality of Life; D018714:Radiotherapy, Adjuvant / Q000379:methods*; D016019:Survival Analysis; D016896:Treatment Outcome