Contribution of oxidative-reductive reactions to high-molecular-weight hyaluronan catabolism.
Since the content of hyaluronan (HA)-degrading enzymes in synovial fluid (SF), if any, is extremely low, the high rate of HA turnover in SF is to result from a cause different from enzymatic catabolism. An alternative and plausible mechanism is that of oxidative-reductive degradation of HA chains by a combined action of oxygen and transition metal cations maintained in a reduced oxidation state by ascorbate.
Soltés
Ladislav
L
Institute of Experimental Pharmacology, Slovak Academy of Sciences, Dúbravská cesta 9, SK-84104 Bratislava. ladislav.soltes@savba.sk
Stankovská
Monika
M
Kogan
Grigorij
G
Gemeiner
Peter
P
Stern
Robert
R
D006820:Hyaluronic Acid / Q000737:chemistry*; D006821:Hyaluronoglucosaminidase / Q000378:metabolism*; D008970:Molecular Weight; D010084:Oxidation-Reduction
D006820:Hyaluronic Acid; D006821:Hyaluronoglucosaminidase