title: Cardiovascular involvement in 8 dogs with blastomyces dermatitidis infection.
abstract: BACKGROUND
  Blastomycosis is a common systemic fungal infection in dogs.
  
  
  OBJECTIVE
  Dogs with cardiovascular involvement may have abnormalities in electrical conduction and valvular function, and may have a worse prognosis.
  
  
  METHODS
  Eight client-owned animals.
  
  
  METHODS
  Dogs with cardiovascular lesions caused by blastomycosis were identified from retrospective evaluation of medical records.
  
  
  RESULTS
  Five dogs had de novo infections and 3 had recurrences of previously treated infections. Harsh labored breathing, lethargy, and anorexia were the most common historic complaints. Three dogs had syncope. Physical examination and clinicopathologic data were typical of blastomycosis and included dyspnea, increased lung sounds, and lethargy. In addition, 3 dogs had heart murmurs and 1 had a third-degree atrioventricular block. Four dogs had myocarditis and 2 had pericarditis or epicarditis. Two dogs had cardiac signs attributed to extracardiac compression by fungal granulomas and clinical signs were relieved by treatment. Half of the remaining 6 dogs were euthanized; 2 of these were not treated. Of the remaining 3 dogs, 1 dog died acutely while sleeping; the second died intraoperatively during an attempt to place an epicardial pacemaker; and the third had Blastomyces-induced endocarditis and died of heart failure.
  
  
  CONCLUSIONS
  Blastomycosis should be considered in the differential diagnosis of dogs from endemic areas with inflammatory myocarditis, heart block, heart base or intracardiac mass lesions, syncope, or endocarditis.
authors.affiliation: Department of Surgical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, MI, USA. schmiedtc@svm.vetmed.wisc.edu
authors.forename: Chad
authors.initials: C
authors.lastname: Schmiedt
authors.forename: Heidi
authors.initials: H
authors.lastname: Kellum
authors.forename: Alfred M
authors.initials: AM
authors.lastname: Legendre
authors.forename: Rebecca E
authors.initials: RE
authors.lastname: Gompf
authors.forename: Janice M
authors.initials: JM
authors.lastname: Bright
authors.forename: Christopher D
authors.initials: CD
authors.lastname: Houle
authors.forename: Melissa
authors.initials: M
authors.lastname: Schutten
authors.forename: Rebecca
authors.initials: R
authors.lastname: Stepien
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000627:therapeutic use; D001758:Blastomyces; D001759:Blastomycosis / Q000150:complications / Q000401:mortality / Q000662:veterinary*; D002318:Cardiovascular Diseases / Q000382:microbiology / Q000401:mortality / Q000473:pathology / Q000662:veterinary*; D002423:Cause of Death; D003937:Diagnosis, Differential; D004283:Dog Diseases / Q000382:microbiology* / Q000401:mortality / Q000473:pathology*; D004285:Dogs; D005260:Female; D008297:Male; D011379:Prognosis; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D000935:Antifungal Agents