Enantioselective organocatalysis.
Enantioselective organocatalysis has emerged as a powerful synthetic paradigm that is complementary to metal-catalysed transformations and has accelerated the development of new methods to make diverse chiral molecules. The operational simplicity, ready availability of catalysts and low toxicity associated with organocatalysis makes it an attractive method to synthesise complex structures. Here, we discuss the impact of enamine, iminium, nucleophilic and Brønsted acid catalysts in organic synthesis, and highlight key strategic methods to assemble useful molecules with high enantiomeric purity.
Gaunt
Matthew J
MJ
Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK. mjg32@cam.ac.uk
Johansson
Carin C C
CC
McNally
Andy
A
Vo
Ngoc T
NT
D002384:Catalysis; D002625:Chemistry, Organic / Q000379:methods; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry*; D013237:Stereoisomerism
D009942:Organometallic Compounds