title: Acridone and furoquinoline alkaloids from Teclea gerrardii (Rutaceae: Toddalioideae) of southern Africa.
abstract: The combined hexane/CH(2)Cl(2) extract of the stem bark of Teclea gerrardii (Rutaceae: Toddalioideae) has yielded two acridone alkaloids, 3-hydroxy-1-methoxy-N-methylacridone (tegerrardin A) (1) and 3-hydroxy-N-methyl-1-(gamma,gamma-dimethylallyloxy)acridone (tegerrardin B) (2), three known acridones (3-5), two known furoquinolines (6,7), and the acridone precursor tecleanone (8). Arborinine (3) and evoxine (6) displayed moderate antiplasmodial activity against the CQS D10 strain of Plasmodium falciparum, with IC(50) values of 12.3 and 24.5 microM, respectively.
authors.affiliation: School of Chemistry, University of KwaZulu-Natal, Howard College Campus, 4041, Durban, South Africa.
authors.forename: Alain F Kamdem
authors.initials: AF
authors.lastname: Waffo
authors.forename: Philip H
authors.initials: PH
authors.lastname: Coombes
authors.forename: Neil R
authors.initials: NR
authors.lastname: Crouch
authors.forename: Dulcie A
authors.initials: DA
authors.lastname: Mulholland
authors.forename: Sawsan M M
authors.initials: SM
authors.lastname: El Amin
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Smith
mesh_terms: D000166:Acridines / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D054831:Acridones; D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D000818:Animals; D000962:Antimalarials / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D002163:Cameroon; D018547:Plant Stems / Q000737:chemistry; D010963:Plasmodium falciparum / Q000187:drug effects*; D011804:Quinolines / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D027821:Rutaceae / Q000737:chemistry* / Q000254:growth & development; D013019:South Africa
chemical_list: D000166:Acridines; D054831:Acridones; D000470:Alkaloids; D000962:Antimalarials; D011804:Quinolines; C041300:acridone