Review: Negative regulation of leptin receptor signalling.
Leptin was discovered as an adipostat, regulating body weight by balancing food intake and energy expenditure. Recently, leptin emerged as a pleiotropic cytokine. It plays a substantial role in a wide spectrum of other functions including immune regulation, bone formation and fertility. Leptin signalling is under tight control. Aberrations of this stringent control system may be implicated in a variety of pathologies. Here, we review the various mechanisms that control cellular leptin receptor signalling.
Lavens
Delphine
D
Department of Medical Protein Research, Faculty of Medicine and Health Sciences, Flanders Interuniversity Institute for Biotechnology, VIB09, Ghent University, A. Baertsoenkaai 3, B-9000 Ghent.
Piessevaux
Julie
J
Tavernier
Jan
J
D000818:Animals; D006801:Humans; D010744:Phosphoric Monoester Hydrolases / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000378:metabolism*; D054411:Receptors, Leptin; D015398:Signal Transduction; D050826:Suppressor of Cytokine Signaling Proteins / Q000378:metabolism
C515448:LEPR protein, human; D011956:Receptors, Cell Surface; D054411:Receptors, Leptin; D050826:Suppressor of Cytokine Signaling Proteins; D010744:Phosphoric Monoester Hydrolases