Flow Focusing: a versatile technology to produce size-controlled and specific-morphology microparticles.
The Flow Focusing platform is especially advantageous for micro- and nanoparticle production. This versatile technique is amenable to designing the size, surface treatment and internal topology of the particles; mechanical stresses are minimal-an optimal feature for the manipulation of delicate substances. Multiplexing and high-rate production are readily implemented. Adaptive operational design can lead, in one single step, to finely tuned microcapsules encasing different products within a targeted morphology. This achievement is of great significance for most microcapsule applications in the biosciences (for example, drug delivery, cell encapsulation, and the production of bead arrays).
Martín-Banderas
Lucía
L
Dpto. Mecánica de Fluidos, Escuela Superior de Ingenieros, Universidad de Sevilla, Camino de los Descubrimientos s/n, 41092 Sevilla, Spain.
Flores-Mosquera
María
M
Riesco-Chueca
Pascual
P
Rodríguez-Gil
Alfonso
A
Cebolla
Angel
A
Chávez
Sebastián
S
Gañán-Calvo
Alfonso M
AM
D004337:Drug Carriers; D004339:Drug Compounding; D016503:Drug Delivery Systems; D005456:Fluorescent Dyes / Q000494:pharmacology; D019344:Lactic Acid / Q000737:chemistry; D044085:Microfluidics; D008855:Microscopy, Electron, Scanning; D008863:Microspheres; D053758:Nanoparticles / Q000737:chemistry; D036103:Nanotechnology / Q000191:economics / Q000295:instrumentation / Q000379:methods*; D010316:Particle Size; D011100:Polyglycolic Acid / Q000737:chemistry; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011108:Polymers / Q000737:chemistry; D011137:Polystyrenes / Q000737:chemistry; D012997:Solvents
D004337:Drug Carriers; D005456:Fluorescent Dyes; D011108:Polymers; D011137:Polystyrenes; D012997:Solvents; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid