title: Inhaled milrinone: a new alternative in cardiac surgery?
abstract: The administration of milrinone through inhalation has been studied in only a few animal and human studies. Compared to the intravenous administration, inhaled milrinone has been shown to reduce pulmonary artery pressure without systemic hypotension. Therefore, this approach could represent an alternative to nitric oxide. This current state of knowledge of intravenous and inhaled milrinone is presented and summarized.
authors.affiliation: Department of Cardiac Anesthesiology, Montreal Heart Institute, Université de Montréal, Montreal, Quebec, Canada. denault@videotron.ca
authors.forename: André Y
authors.initials: AY
authors.lastname: Denault
authors.forename: Yoan
authors.initials: Y
authors.lastname: Lamarche
authors.forename: Pierre
authors.initials: P
authors.lastname: Couture
authors.forename: Francois
authors.initials: F
authors.lastname: Haddad
authors.forename: Jean
authors.initials: J
authors.lastname: Lambert
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Tardif
authors.forename: Louis P
authors.initials: LP
authors.lastname: Perrault
mesh_terms: D000280:Administration, Inhalation; D000818:Animals; D023381:Endpoint Determination / Q000379:methods; D006334:Heart Function Tests; D006801:Humans; D006976:Hypertension, Pulmonary / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D007275:Injections, Intravenous; D020105:Milrinone / Q000008:administration & dosage* / Q000494:pharmacology; D008991:Monitoring, Physiologic; D010726:Phosphodiesterase Inhibitors / Q000008:administration & dosage* / Q000494:pharmacology; D013552:Swine; D019616:Thoracic Surgical Procedures / Q000009:adverse effects; D016896:Treatment Outcome
chemical_list: D010726:Phosphodiesterase Inhibitors; D020105:Milrinone