Telithromycin inhibits the number of viable bacteria but not lymphocyte accumulation in a murine model of chronic respiratory infection.
The 14-membered macrolides, such as clarithromycin (CAM) and erythromycin (EM), are effective against diffuse panbronchiolitis. However, there have been no studies on the effects of telithromycin (TEL) on chronic respiratory infection in vivo. In this study, we determined the effect of TEL on an experimental murine model of chronic respiratory infection caused by Pseudomonas aeruginosa with biofilm formation. TEL significantly reduced the number of viable bacteria but had no effect on the proliferation of lymphocytes. In contrast, CAM decreased the number of lymphocytes but had no effect on the number of viable bacteria in the lung. These results suggest that TEL and CAM have different effects on chronic respiratory infection caused by P. aeruginosa.
Yanagihara
Katsunori
K
Second Department of Internal Medicine, Nagasaki University Graduate School of Pharmaceutical Sciences, Nagasaki, Japan. kyana-ngs@umin.ac.jp
Kuroki
Misuzu
M
Higuchi
Norihide
N
Ohno
Hideaki
H
Higashiyama
Yasuhito
Y
Miyazaki
Yoshitsugu
Y
Hirakata
Yoichi
Y
Mukae
Hiroshi
H
Tomono
Kazunori
K
Mizuta
Yohei
Y
Kadota
Jun-Ichi
J
Tsukamoto
Kazuhiro
K
Kohno
Shigeru
S
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use; D018441:Biofilms / Q000187:drug effects; D002908:Chronic Disease; D017291:Clarithromycin / Q000494:pharmacology / Q000627:therapeutic use; D004195:Disease Models, Animal; D048628:Ketolides / Q000494:pharmacology* / Q000627:therapeutic use; D008168:Lung / Q000276:immunology; D008214:Lymphocytes / Q000187:drug effects; D008297:Male; D051379:Mice; D011552:Pseudomonas Infections / Q000188:drug therapy*; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000302:isolation & purification; D012141:Respiratory Tract Infections / Q000188:drug therapy* / Q000382:microbiology
D000900:Anti-Bacterial Agents; D048628:Ketolides; D017291:Clarithromycin; C106791:telithromycin