Effect of ultraviolet radiation-induced inflammation on epidermal wound healing.
To examine the influence of ultraviolet radiation, a potent inducer of interleukin-1 and other growth factors, on the rate of epidermal migration, we used a porcine model of wound healing. Wounds were treated in one of the following treatment groups: (1) two minimal erythema doses of ultraviolet radiation once daily for 2 days before wounding, (2) two minimal erythema doses of ultraviolet radiation once daily for 2 days before wounding followed with continuous treatment until all wounds were 100% epithelized, (3) or no ultraviolet radiation treatment until healing was complete. Using a macroscopic salt-split technique, we examined epidermal specimens macroscopically for epithelialization. Treatment both before and after ultraviolet radiation significantly enhanced epithelialization when compared with non-ultraviolet radiation-treated control wounds. These experiments show that ultraviolet radiation treatment can augment the rate of healing of partial-thickness wounds.
Kaiser
M R
MR
Department of Dermatology and Cutaneous Surgery, University of Miami School of Medicine, Miami, Florida 33136, USA.
Davis
S C
SC
Mertz
B A
BA