Antitumor-promoting effects of new sesquiterpenes from Crossopetalum tonduzii.
Seven new sesquiterpenes (1-7) with a 'dihydro-beta-agarofuran' (= 5,11-epoxy-5beta,10alpha-eudesmane) skeleton were isolated from Crossopetalum tonduzii. Their structures were elucidated spectroscopically, especially by means of homo- and heteronuclear NMR correlation (COSY, ROESY, HSQC, and HMBC). The absolute configurations of the new compounds were determined by circular dichroism (CD) studies and by chemical correlations via the derivatives 8-11. The new compounds showed moderate antitumor-promoting effects with respect to the activation of the Epstein-Barr virus early antigen (EBV-EA).
Mendoza
Cristina R
CR
Instituto Universitario de Bio-Orgánica Antonio González, Universidad de La Laguna, Avenida Astrofísico Francisco Sánchez 2, La Laguna, 38206 Tenerife.
Jiménez
Ignacio A
IA
Tokuda
Harukuni
H
Kushida
Hiroyuki
H
Bazzocchi
Isabel L
IL
D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D029753:Celastraceae / Q000737:chemistry*; D045744:Cell Line, Tumor; D006801:Humans; D015394:Molecular Structure; D012717:Sesquiterpenes / Q000737:chemistry* / Q000494:pharmacology*
D000970:Antineoplastic Agents; D012717:Sesquiterpenes