title: Outcome of in vitro fertilization in women 45 years and older who use autologous oocytes.
abstract: OBJECTIVE
  To determine the IVF outcome in women over the age of 44 years.
  
  
  METHODS
  Retrospective analysis.
  
  
  METHODS
  University-based IVF center.
  
  
  METHODS
  Two hundred eighty-eight consecutive IVF cycles in women over the age of 44 years.
  
  
  METHODS
  IVF.
  
  
  METHODS
  Ovarian response and cycle outcome.
  
  
  RESULTS
  The mean age of the patients was 45.4 (+/-0.73) years, with a range of 45-49 years. Fifty-seven of 288 (19.8%) did not start because of an elevated FSH or ovarian cyst. Just over 30% (70/231) had their cycle cancelled before retrieval. The mean number of oocytes was 6.8 (+/-3.8), and the mean number of fertilized zygotes was 5.4 (+/-3.4). On average, the mean numbers of embryos replaced were 3.2 (+/-1.5). An overall pregnancy rate of 21.1% (34/161) per retrieval was found. Of these, 85.3% (29/34) experienced a pregnancy loss. The overall delivery rate was 3.1% (5/161) per retrieval. Only patients at 45 years of age with a good response (>5 oocytes) achieved a delivery.
  
  
  CONCLUSIONS
  We have shown that IVF is a reasonable option for women of very advanced maternal age (>44 years) but is limited to those at the age of 45 years with a response of >5 oocytes.
authors.affiliation: The Center for Reproductive Medicine and Infertility, The New York Presbyterian Hospital/Weill Medical College of Cornell University, New York, New York 10021, USA. sdspando@med.cornell.edu
authors.forename: Steven D
authors.initials: SD
authors.lastname: Spandorfer
authors.forename: Kristin
authors.initials: K
authors.lastname: Bendikson
authors.forename: Kate
authors.initials: K
authors.lastname: Dragisic
authors.forename: Glenn
authors.initials: G
authors.lastname: Schattman
authors.forename: Owen K
authors.initials: OK
authors.lastname: Davis
authors.forename: Zev
authors.initials: Z
authors.lastname: Rosenwaks
mesh_terms: D000367:Age Factors; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods / Q000706:statistics & numerical data*; D006801:Humans; D008875:Middle Aged; D009518:New York; D009865:Oocytes / Q000637:transplantation*; D017063:Outcome Assessment, Health Care; D011247:Pregnancy; D011256:Pregnancy Outcome / Q000453:epidemiology*; D012189:Retrospective Studies; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D014182:Transplantation, Autologous / Q000706:statistics & numerical data*; D016896:Treatment Outcome