title: A novel method for evaluating human carotid artery elasticity: possible detection of early stage atherosclerosis in subjects with type 2 diabetes.
abstract: We recently developed a novel method for evaluating the elasticity of arterial walls, the phased tracking method. Herein, we evaluated atherosclerosis of the carotid artery with this method in 242 individuals with type 2 diabetes. In multiple regression analysis of subject status, age, systolic blood pressure and hyperlipidemia were found to be independently associated with carotid artery elasticity values. We also measured currently established values for atherosclerosis, carotid artery IMT and baPWV, in these subjects. Carotid artery elasticity correlated with max IMT (r=0.291, p<0.01), plaque score (PS) (r=0.220, p<0.01) and baPWV (r=0.345, p<0.01). Elasticity, max IMT and plaque score, all correlated with the number of risk factors for atherosclerosis, i.e. hypertension, hyperlipidemia and smoking, in addition to diabetes, consistent with the view that these values reflect atherosclerosis. Importantly, however, in subjects with IMT <1.1mm, who are classified as not having atherosclerosis as defined by IMT criteria, only carotid artery elasticity correlated with the number of risk factors (p<0.05). These results suggest that (1) the measured carotid artery elasticity values reflect atherosclerosis and (2) our novel method has potential for detecting atherosclerosis in its early stage.
authors.affiliation: Division of Molecular Metabolism and Diabetes, Tohoku University Graduate School of Medicine, Japan.
authors.forename: Hisashi
authors.initials: H
authors.lastname: Okimoto
authors.affiliation: Division of Molecular Metabolism and Diabetes, Tohoku University Graduate School of Medicine, Japan.
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Ishigaki
authors.affiliation: Division of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Japan.
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Koiwa
authors.affiliation: Division of Molecular Metabolism and Diabetes, Tohoku University Graduate School of Medicine, Japan.
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Hinokio
authors.affiliation: Division of Advanced Therapeutics for Metabolic Diseases, Tohoku University Graduate School of Medicine, Japan.
authors.forename: Takehide
authors.initials: T
authors.lastname: Ogihara
authors.affiliation: Division of Molecular Metabolism and Diabetes, Tohoku University Graduate School of Medicine, Japan.
authors.forename: Susumu
authors.initials: S
authors.lastname: Suzuki
authors.affiliation: Division of Advanced Therapeutics for Metabolic Diseases, Tohoku University Graduate School of Medicine, Japan; The 21st Century COE Programs, Comprehensive Research and Education Center for Planning of Drug Development and Clinical Evaluation, Japan.
authors.forename: Hideki
authors.initials: H
authors.lastname: Katagiri
authors.affiliation: Department of Planning for Drug Development and Clinical Evaluation, Tohoku University Graduate School of Pharmaceutical Science and Medicine, Japan; The 21st Century COE Programs, Comprehensive Research and Education Center for Planning of Drug Development and Clinical Evaluation, Japan.
authors.forename: Takayoshi
authors.initials: T
authors.lastname: Ohkubo
authors.affiliation: Department of Electrical Engineering, Tohoku University Graduate School of Engineering, Japan.
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Hasegawa
authors.affiliation: Department of Electrical Engineering, Tohoku University Graduate School of Engineering, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kanai
authors.affiliation: Division of Molecular Metabolism and Diabetes, Tohoku University Graduate School of Medicine, Japan; The 21st Century COE Programs, Center for Innovative Therapeutic Development towards the Conquest of Signal Transduction Diseases, Tohoku University, Sendai, Japan. Electronic address: oka-y@mail.tains.tohoku.ac.jp.
authors.forename: Yoshitomo
authors.initials: Y
authors.lastname: Oka
mesh_terms: D000368:Aged; D002339:Carotid Arteries / Q000473:pathology*; D002340:Carotid Artery Diseases / Q000000981:diagnostic imaging* / Q000209:etiology; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D004548:Elasticity; D054459:Elasticity Imaging Techniques / Q000379:methods*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011673:Pulsatile Flow; D017539:Tunica Intima / Q000000981:diagnostic imaging / Q000473:pathology; D017540:Tunica Media / Q000000981:diagnostic imaging / Q000473:pathology