title: BF3.Et2O-catalyzed direct carbon-carbon bond formation of alpha-EWG Ketene-(S,S)-acetals and alcohols and synthesis of unsymmetrical biaryls.
abstract: A highly efficient BF3.OEt2-catalyzed formal dehydration C-C coupling reaction between readily available alpha-EWG ketene-(S,S)-acetals and various alcohols via direct substitution of the hydroxy group in alcohols has been developed. On the basis of this C-C coupling reaction, a series of alkylated alpha-EWG ketene-(S,S)-acetals and functionalized 1,4-pentanedienes were prepared in high to excellent yields and the unsymmetrical biaryls were synthesized in good yields from the generated 1,4-pentanedienes and nitroalkanes through a one-pot annulation-aromatization process.
authors.affiliation: Department of Chemistry, Northeast Normal University, 5268 Renmin Street, Changchun 130024, P R China. zhangq651@nenu.edu.cn
authors.forename: Qian
authors.initials: Q
authors.lastname: Zhang
authors.forename: Shaoguang
authors.initials: S
authors.lastname: Sun
authors.forename: Jianglei
authors.initials: J
authors.lastname: Hu
authors.forename: Qun
authors.initials: Q
authors.lastname: Liu
authors.forename: Jing
authors.initials: J
authors.lastname: Tan