title: Radiofrequency ablation of normal lungs after pulmonary artery embolization with use of degradable starch microspheres: results in a porcine model.
abstract: OBJECTIVE
  The present study was performed to evaluate the effect of pulmonary artery embolization on radiofrequency (RF) ablation of normal porcine lungs.
  
  
  METHODS
  RF ablation zones (n=34) were created in the normal lungs of five domestic pigs (five zones in each of the first two pigs and eight zones in each of the remaining three pigs) with an expandable multitined electrode with use of bilateral thoracotomy. RF ablation was performed without pulmonary artery embolization (group 1, n=8), immediately after embolization (group 2, n=11), 15 minutes after embolization (group 3, n=7), and 30 minutes after embolization (group 4, n=8) with degradable starch microspheres. Among them, 12 ablation zones were excluded from this study because they were considerably limited by the presence of the pleura or large bronchi. The remaining 22 zones were included (n=7, n=5, n=4, and n=6 in groups 1, 2, 3, and 4, respectively). Coagulation necrosis volumes in the ablation zones were measured and compared among the groups.
  
  
  RESULTS
  Coagulation necrosis volumes were 0.9+/-0.5 cm3, 2.1+/-0.4 cm3, 2.1+/-1.0 cm3, and 1.9+/-0.6 cm3 in groups 1, 2, 3, and 4, respectively. Groups 2-4 showed significantly larger coagulation volumes than group 1 (P=.012, P=.023, and P=.010 in groups 2, 3, and 4, respectively).
  
  
  CONCLUSIONS
  Pulmonary artery embolization contributed to larger volumes of coagulation necrosis after RF ablation of normal lungs.
authors.affiliation: Department of Radiology, Okayama University Medical School, 2-5-1 Shikatacho, Okayama 700-8558, Japan. takaoh@tc4.so-net.ne.jp
authors.forename: Takao
authors.initials: T
authors.lastname: Hiraki
authors.forename: Hideo
authors.initials: H
authors.lastname: Gobara
authors.forename: Jun
authors.initials: J
authors.lastname: Sakurai
authors.forename: Hidefumi
authors.initials: H
authors.lastname: Mimura
authors.forename: Takashi
authors.initials: T
authors.lastname: Mukai
authors.forename: Soichiro
authors.initials: S
authors.lastname: Hase
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Iguchi
authors.forename: Hiroyasu
authors.initials: H
authors.lastname: Fujiwara
authors.forename: Nobuhisa
authors.initials: N
authors.lastname: Tajiri
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Yanai
authors.forename: Tadashi
authors.initials: T
authors.lastname: Yoshino
authors.forename: Susumu
authors.initials: S
authors.lastname: Kanazawa
mesh_terms: D000818:Animals; D017115:Catheter Ablation; D004621:Embolization, Therapeutic / Q000379:methods*; D008168:Lung / Q000601:surgery*; D023421:Models, Animal; D009336:Necrosis; D011651:Pulmonary Artery; D013213:Starch; D018709:Statistics, Nonparametric; D034421:Sus scrofa
chemical_list: C083286:degradable starch microspheres; D013213:Starch