Regeneration of the rat spinal cord after thoracic segmentectomy: growth and restoration of nerve conductors.
The results presented in our previous report (Morfologiya, 127, No. 2 (2005)) provided evidence that consolidation of the spinal cord (SC) after thoracic segmentectomy in rats occurs as a result of the formation of a connective tissue scar, which is quicker when the defect is filled with collagen gel. The present report describes analysis of semithin sections and transmission electron microscopy studies demonstrating that regenerating nerve conductors traverse connective tissue in structures whose organization is identical to that of peripheral nerves. In the zone of SC rarefaction caudal to the trauma site, myelination of growing axons is mediated by glial cells without the formation of nerve trunks. Large numbers of fine regenerating conductors were seen at the sites of degenerated myelin fibers in the fasciculi of the white matter in the lumbar segments of the SC.
Yarygin
V N
VN
Faculty of Medical Biology, Russian State Medical University, Moscow, Russia.
Banin
V V
VV
Yarygin
K N
KN
Bryukhovetskii
A S
AS
D000818:Animals; D003238:Connective Tissue / Q000473:pathology / Q000648:ultrastructure; D008161:Lumbosacral Region / Q000473:pathology; D015412:Mastectomy, Segmental / Q000379:methods*; D046529:Microscopy, Electron, Transmission / Q000379:methods; D009413:Nerve Fibers, Myelinated / Q000473:pathology / Q000648:ultrastructure; D009416:Nerve Regeneration / Q000502:physiology*; D009431:Neural Conduction / Q000502:physiology*; D051381:Rats; D020127:Recovery of Function / Q000502:physiology; D013119:Spinal Cord Injuries / Q000473:pathology / Q000503:physiopathology*