title: [Peripheral NK/T-cell lymphoma].
abstract: Peripheral T-cell lymphomas comprise 8% of the malignant lymphomas in Germany. About 25% of these cases present primarily in extranodal localizations. Such localizations are typical for the respective disease and form the basis for the classification of extranodal peripheral T-cell lymphoma. The morphology, immunophenotype and lineage specificity of the tumor cells (originating from T- or NK-cells) is only secondary for the classification. Extranodal NK/T-cell lymphomas of the nasal type are characterized by an angiocentric growth pattern and large confluent areas of necrosis. In addition, there is a clonal infection by Epstein-Barr virus in the T-lymphocytes. In the differential diagnosis, B-cell lymphomas are more frequent at all localizations than T- or NK-cell lymphomas.
authors.affiliation: Institut für Pathologie, Universität Würzburg. thomas.ruediger@mail.uni-wuerzburg.de
authors.forename: T
authors.initials: T
authors.lastname: Rüdiger
authors.forename: A
authors.initials: A
authors.lastname: Zettl
authors.forename: P
authors.initials: P
authors.lastname: Adam
authors.forename: I
authors.initials: I
authors.lastname: Bonzheim
authors.forename: E
authors.initials: E
authors.lastname: Geissinger
authors.forename: H K
authors.initials: HK
authors.lastname: Müller-Hermelink
mesh_terms: D003937:Diagnosis, Differential; D006801:Humans; D016130:Immunophenotyping; D007694:Killer Cells, Natural / Q000276:immunology / Q000473:pathology*; D016393:Lymphoma, B-Cell / Q000145:classification / Q000276:immunology / Q000473:pathology; D016399:Lymphoma, T-Cell / Q000145:classification / Q000276:immunology / Q000473:pathology*; D013601:T-Lymphocytes / Q000276:immunology* / Q000473:pathology