[Apoptosis in myocardial cells after macleaya cordata total alkaloids poisoning in rats].
OBJECTIVE
To observe pathological changes and apoptosis in rats myocardial cells after Macleaya cordata total alkaloids poisoning, and to provide some references for Macleaya cordata total alkaloids poisoning detection.


METHODS
An experimental model of Macleaya cordata total alkaloids poisoning was established, and the technology of TUNEL staining was used.The results were analyzed by computer image analysis competitive system.


RESULTS
Quantities of apoptosis in myocardial cells in poisoning groups were much more than those in the control groups at different tages (P<0.01). In addition the quantities of apoptosis were different after different poisoning duration.


CONCLUSIONS
Although clinical symptoms was not obvious and could not be detected by poison analysis. Pathological changes induced by Macleaya cordata total alkaloids could be found through the apoptosis detection.
Zhang
De-Yu
DY
Department of forensic medicine, Wannan medical college, Wuhu 241001, China.
Zhu
Jian-Hua
JH
Zhao
Wei-Zhi
WZ
Wu
Mao-Wang
MW
Hu
Yong-Liang
YL
Cheng
Li-Bao
LB
Li
Yong-Hong
YH
D000208:Acute Disease; D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D002452:Cell Count; D004195:Disease Models, Animal; D005260:Female; D007150:Immunohistochemistry; D020287:In Situ Nick-End Labeling; D008297:Male; D009206:Myocardium / Q000473:pathology*; D032383:Myocytes, Cardiac / Q000187:drug effects*; D028101:Papaveraceae / Q000737:chemistry*; D010208:Papaverine / Q000008:administration & dosage / Q000506:poisoning*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013194:Staining and Labeling; D013997:Time Factors
D010208:Papaverine