title: Quality of life in patients with Behçet's disease: the impact of major depression.
abstract: OBJECTIVE
  Behçet's disease (BD) is a multisystemic inflammatory disorder associated with high levels of depressive symptoms and lower quality of life (QoL). In this study, we aimed to investigate the impact of major depression (MD) on the QoL of patients with BD.
  
  
  METHODS
  BD outpatients (n=25) and psychiatric outpatients (n=25) with only MD among the Axis I psychiatric disorders, and BD outpatients (n=25) and healthy controls (n=25) without any Axis I psychiatric disorder were included in the study. The Structured Clinical Interview for DSM-IV (SCID-I) was used to determine Axis I psychiatric disorders. Depression and QoL levels were assessed with the Beck Depression Inventory (BDI) and the World Health Organization QoL Assessment-Brief (WHOQOL-BREF), respectively.
  
  
  RESULTS
  There was no significant difference with regard to demographic characteristics between the groups. Psychiatric and BD patients with MD had significantly lower overall WHOQOL-BREF subscale scores than BD patients without MD and healthy controls. No significant difference was found in terms of QoL between the groups of psychiatric and BD patients with MD, nor between the groups of BD patients without MD and healthy controls. Overall, there was a significantly negative correlation between all WHOQOL-BREF subscale and BDI scores in BD patients.
  
  
  CONCLUSIONS
  The study suggests that concurrent MD has a negative impact on QoL of BD patients and that QoL is negatively correlated with the severity of depressive symptoms.
authors.affiliation: Department of Psychiatry, Meram Faculty of Medicine, Selçuk University, Konya 42080, Turkey. farukuguz@hotmail.com
authors.forename: Faruk
authors.initials: F
authors.lastname: Uğuz
authors.forename: Recep
authors.initials: R
authors.lastname: Dursun
authors.forename: Nazmiye
authors.initials: N
authors.lastname: Kaya
authors.forename: Ali Savas
authors.initials: AS
authors.lastname: Cilli
mesh_terms: D000328:Adult; D001528:Behcet Syndrome / Q000453:epidemiology* / Q000523:psychology*; D003710:Demography; D003865:Major Depressive Disorder / Q000175:diagnosis / Q000453:epidemiology* / Q000523:psychology; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D006801:Humans; D008297:Male; D011788:Quality of Life / Q000523:psychology*; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires