Genetic influences on cerebral outcome after cardiac surgery.
Just as the influence of genetic variation on patient outcomes is being discussed in many other areas of medicine, so too are its effects on cerebral outcome after cardiac surgery now being described. Whereas early studies focused on neurocognitive outcome, where the single nucleotide polymorphisms of APOE4 and PL(A2) were the first investigated genetic targets, stroke is now being elaborated on with related single and multi-gene single nucleotide polymorphisms having been identified. Our work has established key links between post-cardiac surgery stroke and C-reactive protein (3'UTR 1846C/T) and interleukin-6 (-174 G/C) single nucleotide polymorphisms.
Grocott
Hilary P
HP
Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA. h.grocott@duke.edu
D016824:Antigens, Human Platelet / Q000235:genetics; D053327:Apolipoprotein E4 / Q000235:genetics; D006348:Cardiac Surgical Procedures / Q000009:adverse effects*; D003072:Cognition Disorders / Q000235:genetics*; D006801:Humans; D020521:Stroke / Q000235:genetics*; D016896:Treatment Outcome
D016824:Antigens, Human Platelet; D053327:Apolipoprotein E4; C083451:human platelet antigen 1b