title: Identification of genotoxic compounds in the airborne particulate matter endowed by small aerodynamic diameter in the city of Catania (Italy).
abstract: Airborne particulate matter (PM) is one of the most important polluting factors in the atmosphere containing solid particles generated during the combustion processes. PM, due to the particle size, is easily inhaled and constitutes a potential hazard for the human health. We previously documented, using in vitro cell culture systems, cytogenetic damages caused by exposure to a non-fractionated PM in two different areas from the city of Catania (Sicily, Italy). In the present work, the PM was fractionated in six different sub-fractions, and the relative extractable organic matters (EOM) were analyzed in order to quantify the presence of Polycyclic Aromatic Hydrocarbons (PHAs), a well known class of genotoxic agents. More than 70% of the total EOM was found in the PM with aerodynamic diameters less than 3.5 microm (PM35), and about 60% of the total EOM was detected between PM0.14 and PM1.2. Also the large amount of all the analyzed PAHs were found between the PM0.14 and PM1.2. The obtained data indicates that the genotoxic effect previously shown on mammalian cells (Chinese hamster epithelial liver cells) should be due, in the large part, to the PM with smaller particle size, namely less than PM1.2.
authors.affiliation: Dipartimento di Biologia Animale "M. La Greca", University of Catania, via Androne 81, 95124 Catania, Italy.
authors.forename: Salvatore
authors.initials: S
authors.lastname: Motta
authors.forename: Vito
authors.initials: V
authors.lastname: Librando
authors.forename: Zelica
authors.initials: Z
authors.lastname: Minniti
authors.forename: Concetta
authors.initials: C
authors.lastname: Federico
authors.forename: Salvatore
authors.initials: S
authors.lastname: Saccone
mesh_terms: D009153:Mutagens / Q000032:analysis*; D010316:Particle Size; D052638:Particulate Matter / Q000737:chemistry*; D011084:Polycyclic Aromatic Hydrocarbons / Q000032:analysis*; D012802:Sicily; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: D009153:Mutagens; D052638:Particulate Matter; D011084:Polycyclic Aromatic Hydrocarbons