title: Abietane diterpenoids from the roots of some Mexican Salvia species (Labiatae): chemical diversity, phytogeographical significance, and cytotoxic activity.
abstract: From the roots of some Mexican Salvia species, classified in subgenus Jungia, several diterpenoids belonging to abietane (i.e., 3-7), salvifolane (9-->20,10-->6)-diabeoabietane) (i.e., 2), and totarane (i.e., 10) carbocyclic skeletons were isolated together with two 20-nor- and one 6,7-secoabietane derivatives, 1 and 9, and 8, respectively. While compounds 2-10 were previously known from different sources, compound 1 is a new 20-norabietane derivative, whose structure was deduced by spectroscopic means and confirmed by X-ray-diffraction analysis. The phytogeographical significance of the distribution of 20-norabietanic diterpenoids in the genus suggested an evolutionary link between the Chinese and New-World Salvias. Compounds 2 and 8 were tested for cell-growth inhibition activity against several human cancer cell lines and human normal lymphocytes, while 2 showed a moderate cytotoxic activity, 8 exhibited a moderate yet selective activity against leukemia cell line.
authors.affiliation: Instituto de Química de la Universidad Nacional Autónoma de México, Circuito Exterior de Ciudad Universitaria, Coyoacán, 04510, México DF. baldo@servidor.unam.mx
authors.forename: Baldomero
authors.initials: B
authors.lastname: Esquivel
authors.forename: Ana Adela
authors.initials: AA
authors.lastname: Sánchez
authors.forename: Fredd
authors.initials: F
authors.lastname: Vergara
authors.forename: Wilber
authors.initials: W
authors.lastname: Matus
authors.forename: Simón
authors.initials: S
authors.lastname: Hernandez-Ortega
authors.forename: M Teresa
authors.initials: MT
authors.lastname: Ramírez-Apan
mesh_terms: D045784:Abietanes / Q000737:chemistry* / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000494:pharmacology*; D005075:Biological Evolution; D045744:Cell Line, Tumor; D006801:Humans; D008958:Models, Molecular; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry; D027544:Salvia / Q000737:chemistry* / Q000378:metabolism*
chemical_list: D045784:Abietanes; D000972:Antineoplastic Agents, Phytogenic