Antibacterial Co(II), Ni(II), Cu(II) and Zn(II) complexes of Schiff bases derived from fluorobenzaldehyde and triazoles.
Antibacterial Schiff bases derived from 1,2,4-triazoles as well as their metal complexes incorporating cobalt(II), nickel(II), copper(II) and zinc(II) have been synthesized and characterized. Physico-chemical studies suggest that an octahedral geometry for the cobalt(II), nickel(II) and zinc(II)and square-planer geometry for the copper(II) complexes. These complexes have been screened for antibacterial activity against three Gram-positive (Staphylococcus aureus, Staphylococcus epidermidis and Bacillus subtilis) and two Gram-negative (Salmonella typhi and Pseudomonas aeruginosa) bacterial strains, and results compared with the activity of the free ligands. The metal complexes were found to be more potent against one or more bacterial strains than the free ligands.
Singh
Kiran
K
Department of Chemistry, Kurukshetra University, Kurukshetra 136119, India.
Singh
D P
DP
Barwa
Manjeet Singh
MS
Tyagi
Parikshit
P
Mirza
Yasmin
Y
D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D001547:Benzaldehydes / Q000737:chemistry* / Q000494:pharmacology*; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D019216:Metals, Heavy / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D012545:Schiff Bases / Q000737:chemistry; D013057:Spectrum Analysis; D013329:Structure-Activity Relationship; D013696:Temperature; D014230:Triazoles / Q000737:chemistry* / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D001547:Benzaldehydes; D019216:Metals, Heavy; D012545:Schiff Bases; D014230:Triazoles; C516422:4-fluorobenzaldehyde