title: Metabolic modelling and the closed-loop insulin delivery problem.
abstract: The approach used by Medtronic MiniMed to close the insulin delivery loop using the subcutaneous site for both glucose sensing and insulin delivery relies on modeling insulin action and beta-cell insulin secretion. This approach is contrasted with traditional control systems engineering.
authors.affiliation: Medtronic MiniMed, Northridge, CA 91325, USA. garry.steil@medtronic.com
authors.forename: Garry
authors.initials: G
authors.lastname: Steil
authors.forename: Kerstin
authors.initials: K
authors.lastname: Rebrin
authors.forename: John J
authors.initials: JJ
authors.lastname: Mastrototaro
mesh_terms: D001786:Blood Glucose / Q000032:analysis; D006801:Humans; D007332:Insulin Infusion Systems; D050417:Insulin-Secreting Cells / Q000378:metabolism; D008954:Models, Biological
chemical_list: D001786:Blood Glucose