title: Influence of maternal smoking on neonatal aortic intima-media thickness, serum IGF-I and IGFBP-3 levels.
abstract: Epidemiological studies have reported associations between a range of cardiovascular risk factors such as smoking and intima-media thickness (IMT). Some reports indicate that the maternal tobacco smoking causes disturbances of the endocrine status of the foetus. There are several potential mechanisms by which insulin-like growth factor I (IGF-I) could modify atherosclerotic processes either locally or in a systemic manner. The aim of this study was to investigate the influence of maternal smoking on neonatal aortic IMT (aIMT), serum IGF-I and IGF-binding protein-3 (IGFBP-3) levels. Aortic intima-media thickness was measured in 28 neonates whose mothers smoked during the pregnancy and 28 control neonates. Mean and weight-adjusted aIMT were significantly greater in the neonates whose mothers smoked (0.455 +/- 0.009 mm and 0.151 +/- 0.005 mm/kg, respectively) than in controls (0.403 +/- 0.029 mm and 0.118 +/- 0.014 mm/kg, respectively). Birth-weight of newborns whose mothers smoked was less than that of the controls. The decreases in serum IGF-I and IGFBP-3 observed in the infants whose mothers smoked were non-significant. Mean aIMT was negatively associated with birth-weight and IGF-I level. In conclusion, neonates whose mothers smoked have significantly increased aIMT. It might play a role in the pathogenesis of atherosclerosis in adult life.
authors.affiliation: Department of Paediatrics, Division of Neonatology,, School of Medicine, Erciyes University, Kayseri, Turkey.
authors.forename: Tamer
authors.initials: T
authors.lastname: Gunes
authors.forename: Esad
authors.initials: E
authors.lastname: Koklu
authors.forename: Ali
authors.initials: A
authors.lastname: Yikilmaz
authors.forename: Mehmet Adnan
authors.initials: MA
authors.lastname: Ozturk
authors.forename: Mustafa
authors.initials: M
authors.lastname: Akcakus
authors.forename: Selim
authors.initials: S
authors.lastname: Kurtoglu
authors.forename: Abdulhakim
authors.initials: A
authors.lastname: Coskun
authors.forename: Selmin
authors.initials: S
authors.lastname: Koklu
mesh_terms: D000328:Adult; D001011:Aorta / Q000033:anatomy & histology* / Q000000981:diagnostic imaging / Q000187:drug effects; D001724:Birth Weight; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000097:blood*; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D016015:Logistic Models; D008297:Male; D018811:Maternal Exposure / Q000009:adverse effects; D011247:Pregnancy; D012907:Smoking / Q000009:adverse effects* / Q000097:blood; D017539:Tunica Intima / Q000033:anatomy & histology / Q000000981:diagnostic imaging; D017540:Tunica Media / Q000033:anatomy & histology / Q000000981:diagnostic imaging; D014463:Ultrasonography
chemical_list: D018972:Insulin-Like Growth Factor Binding Protein 3; D007334:Insulin-Like Growth Factor I