Transforming growth factor-beta1 polymorphisms in patients with brucellosis: an association between codon 10 and 25 polymorphisms and brucellosis.
This study examined the association between transforming growth factor (TGF)-beta1 polymorphisms and brucellosis. The TGF-beta1 genotypes at codons 10 and 25 were determined by an amplification refractory mutation system-PCR among 425 brucellosis patients and 213 healthy volunteers. The frequencies of TGF-beta1 codons 10 C and 25 G were significantly higher among patients than among controls, as was that of TGF-beta1 codon 10 C/C. The high-producer haplotype (CG/TG) was more frequent among patients than among controls. The findings suggest that genetic polymorphism in codons 10 and 25 of the TGF-beta1 gene might contribute to the development of brucellosis.
Rafiei
A
A
Department of Immunology and Microbiology, Sari Medical School, Mazandaran University of Medical Sciences, Sari, Iran. Rafiei1710@gmail.com
Hajilooi
M
M
Shakib
R J
RJ
Alavi
S A
SA
D002006:Brucellosis / Q000235:genetics*; D003062:Codon / Q000235:genetics*; D005260:Female; D005838:Genotype; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic; D012307:Risk Factors; D053773:Transforming Growth Factor beta1 / Q000235:genetics*
D003062:Codon; D053773:Transforming Growth Factor beta1