New vistas on macrophage differentiation and activation.
Plasticity and heterogeneity are hallmarks of myelomonocytic differentiation and polarized activation. Evidence published in this issue of the European Journal of Immunology, together with other recent data, add new elements and perspectives to the current understanding of mononuclear phagocyte differentiation and activation and are discussed in this Commentary.
Mantovani
Alberto
A
Istituto Clinico Humanitas, Milan, Italy. alberto.mantovani@humanitas.it
Sica
Antonio
A
Locati
Massimo
M
D000818:Animals; D002454:Cell Differentiation / Q000276:immunology*; D016764:Cell Polarity / Q000276:immunology; D006801:Humans; D008262:Macrophage Activation / Q000276:immunology*; D008264:Macrophages / Q000166:cytology* / Q000276:immunology* / Q000378:metabolism