Endoscopic full-thickness closure of large gastric perforations by use of tissue anchors.
BACKGROUND
A flexible needle-catheter tissue-anchoring device was developed to accomplish full-thickness tissue apposition of the GI wall. The aim of this study was to identify the performance of this device for repair of large iatrogenic gastric perforations in a porcine model.


OBJECTIVE
Six pigs.


METHODS
Short-term survival animal study.


METHODS
Pigs were studied while they were under general anesthesia. Device performance in differing gastric locations and wall thicknesses was assessed by 2 perforations more than 2 cm in size created for each pig along the greater curvature and the anterior wall.


METHODS
Each perforation was closed by parallel placement of tissue anchor sets sequentially along the length of the perforation.


METHODS
One week follow-up endoscopy and necropsy were performed.


RESULTS
Twelve perforations were closed with the 48 tissue anchor sets. All animals survived for 1 week without clinical complications. Follow-up endoscopy and necropsy revealed that all tissue anchors remained with firmly held sutures and sealed perforations.


CONCLUSIONS
Full-thickness closure with a new tissue-anchoring device simply and successfully repaired large iatrogenic gastric perforations.
Sumiyama
Kazuki
K
Developmental Endoscopy Unit, Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA.
Gostout
Christopher J
CJ
Rajan
Elizabeth
E
Bakken
Timothy A
TA
Deters
Jodie L
JL
Knipschield
Mary A
MA
D000818:Animals; D002404:Catheterization; D016099:Endoscopy, Gastrointestinal; D004867:Equipment Design; D023421:Models, Animal; D013272:Stomach Diseases / Q000601:surgery*; D013536:Suture Techniques / Q000295:instrumentation*; D013552:Swine