title: Pseudoglandular schwannoma of the cauda equina. Case report.
abstract: The authors present a case of pseudoglandular schwannoma with immunohistochemical findings consistent with epithelial metaplasia. Pseudoglandular schwannoma is a rare morphological variant of benign schwannoma characterized by the presence of glandlike structures lined with Schwann cells. To the best of the authors' knowledge, this is only the fifth case of pseudoglandular schwannoma reported in the literature. Clinical, imaging, and pathological findings are described. The pathological findings were consistent with a pseudoglandular schwannoma composed of typical Schwann cells arranged in an Antoni B pattern, with numerous large pseudocystic spaces. Serial immunohistochemical studies of tissue sections revealed that the cells lining the pseudoglandular spaces were not only diffusely reactive for S100 protein, but also demonstrated focal positivity for epithelial membrane antigen and cytokeratins AE and AE3. The particular immunohistochemical features of incompletely differentiated Schwann cells in the present case give support to the metaplastic theory of the origin of glandlike structures in benign peripheral nerve sheath tumors.
authors.affiliation: Department of Neurosurgery, Tor Vergata University, Rome, Italy. francesco.ruggeri8@tin.it
authors.forename: Francesco
authors.initials: F
authors.lastname: Ruggeri
authors.forename: Leonardo
authors.initials: L
authors.lastname: De Cerchio
authors.forename: Arianna
authors.initials: A
authors.lastname: Bakacs
authors.forename: Augusto
authors.initials: A
authors.lastname: Orlandi
authors.forename: Pierpaolo
authors.initials: P
authors.lastname: Lunardi
mesh_terms: D000328:Adult; D002420:Cauda Equina / Q000473:pathology*; D004848:Epithelium / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D007633:Keratins / Q000378:metabolism; D008297:Male; D008679:Metaplasia; D009442:Neurilemmoma / Q000378:metabolism / Q000473:pathology*; D010524:Peripheral Nervous System Neoplasms / Q000378:metabolism / Q000473:pathology*; D009418:S100 Proteins / Q000378:metabolism; D012583:Schwann Cells / Q000473:pathology
chemical_list: D009418:S100 Proteins; D007633:Keratins