title: ent-Abietane diterpenoids from Isodon rubescens var. rubescens.
abstract: ent-Abietane diterpenoids, hebeiabinins A-F (1-5), together with seven known diterpenoids were isolated from leaves of Isodon rubescens var. rubescens. The structures of 1-5 were established on the basis of spectroscopic analyses, including application of 2D NMR spectroscopic techniques. The diterpenoids isolated were evaluated for the cytotoxicity against A549, HT-29, and K562 tumor cells. Compound 5 was the most active with IC(50) value of 0.91 microM against A549 cells.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China.
authors.forename: Sheng-Xiong
authors.initials: SX
authors.lastname: Huang
authors.forename: Jian-Xin
authors.initials: JX
authors.lastname: Pu
authors.forename: Wei-Lie
authors.initials: WL
authors.lastname: Xiao
authors.forename: Li-Mei
authors.initials: LM
authors.lastname: Li
authors.forename: Zhi-Ying
authors.initials: ZY
authors.lastname: Weng
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhou
authors.forename: Quan-Bin
authors.initials: QB
authors.lastname: Han
authors.forename: Shu-Lin
authors.initials: SL
authors.lastname: Peng
authors.forename: Li-Sheng
authors.initials: LS
authors.lastname: Ding
authors.forename: Li-Guang
authors.initials: LG
authors.lastname: Lou
authors.forename: Han-Dong
authors.initials: HD
authors.lastname: Sun
mesh_terms: D045784:Abietanes / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D000970:Antineoplastic Agents / Q000633:toxicity; D045744:Cell Line, Tumor / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects*; D006801:Humans; D037602:Isodon / Q000737:chemistry* / Q000633:toxicity; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry*
chemical_list: D045784:Abietanes; D000970:Antineoplastic Agents; D010936:Plant Extracts