Isomeric eremophilane lactones from Senecio tsoongianus.
From the whole plant of Senecio tsoongianus, two pairs of epimers, tsoongianolides A (1) and B (2), and tsoongianolides C (3) and D (4), and two new sesquiterpene lactones, tsoongianolides E (5) and F (6), all of which possess the eremophilane skeleton, were isolated. Two known eremophilane dimers (7) and (8) were also obtained from this species. Their absolute structures were elucidated by 1D- and 2D-NMR techniques and by X-ray diffraction studies, along with chemical evidence.
Zhao
Yu
Y
Department of Traditional Chinese Medicine and Natural Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310031, PR China. dryuzhao@zju.edu.cn
Jiang
Hao
H
MacLeod
Murray
M
Parsons
Simon
S
Rankin
David W H
DW
Wang
Peng
P
Cheng
Christopher H K
CH
Shi
Hao
H
Hao
Xiaojiang
X
Guéritte
Françoise
F
D007536:Isomerism; D007783:Lactones / Q000737:chemistry* / Q000302:isolation & purification; D009281:Naphthalenes / Q000737:chemistry* / Q000302:isolation & purification; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification; D018514:Plant Structures; D000081223:Polycyclic Sesquiterpenes; D012674:Senecio; D012717:Sesquiterpenes
D007783:Lactones; D009281:Naphthalenes; D010936:Plant Extracts; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes; C018286:eremophilane compounds