title: Brownian motion, fluctuation and life.
abstract: The measurements of dynamic behaviors of biomolecules in relation to their functions have been allowed using single molecule measurements. Thermal Brownian motion causes random step motion of motor proteins and structural fluctuation of protein molecules between multiple states. In hierarchic structure of life, the fluctuation is modulated. Random fluctuation is biased to directional motion and reactions as a result of interaction of proteins. The fluctuation of kinetic state of signaling proteins results in polarization and localization of cells. A recognition process in brain is also explained by the equation analogous to biochemical reaction at the molecular level. Thus dynamic processes originated from thermal motion may play an important role in activation processes in life.
authors.affiliation: Graduate School of Frontier Biosciences, Osaka University, 1-3 Yamadaoka, Suita, Osaka 565-0871, Japan. yanagida@phys1.med.osaka-u.ac.jp
authors.forename: Toshio
authors.initials: T
authors.lastname: Yanagida
authors.forename: Masahiro
authors.initials: M
authors.lastname: Ueda
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Murata
authors.forename: Seiji
authors.initials: S
authors.lastname: Esaki
authors.forename: Yoshiharu
authors.initials: Y
authors.lastname: Ishii
mesh_terms: D000199:Actins / Q000737:chemistry / Q000502:physiology; D000818:Animals; D055592:Biophysical Phenomena; D001703:Biophysics; D016547:Kinesins / Q000737:chemistry / Q000502:physiology; D008954:Models, Biological; D008958:Models, Molecular; D020409:Molecular Motor Proteins / Q000737:chemistry / Q000502:physiology; D009038:Motion; D009218:Myosins / Q000737:chemistry / Q000502:physiology; D011487:Protein Conformation; D011506:Proteins / Q000737:chemistry / Q000502:physiology; D015398:Signal Transduction; D013269:Stochastic Processes; D049490:Systems Biology; D013816:Thermodynamics
chemical_list: D000199:Actins; D020409:Molecular Motor Proteins; D011506:Proteins; D009218:Myosins; D016547:Kinesins