Oppositines A and B, sesquiterpene pyridine alkaloids from a Sri Lankan Pleurostylia opposita.
Two new sesquiterpene pyridine alkaloids, oppositines A (1) and B (2), have been isolated from the plant Pleurostylia opposita, collected in Sri Lanka. The compounds were isolated and purified by solvent/solvent partitioning, column chromatography, and HPLC. Their structures were assigned on the basis of extensive 1D and 2D NMR studies as well as analysis by HRESIMS. Oppositines A (1) and B (2) showed moderate cytotoxicity against HCT116 cell lines with EC50 values of 27 +/- 2 and 26 +/- 3 microM, respectively.
Whitson
Emily L
EL
Department of Medicinal Chemistry, University of Utah, Salt Lake City, UT 84112, USA.
Mala
S M V Damayanthi
SM
Veltri
Charles A
CA
Bugni
Tim S
TS
de Silva
E Dilip
ED
Ireland
Chris M
CM
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D029753:Celastraceae / Q000737:chemistry*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013188:Sri Lanka
D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D012717:Sesquiterpenes; C516373:oppositine A; C516374:oppositine B