Pulmonary-renal syndrome, diffuse pulmonary hemorrhage and glomerulonephritis, associated with Wegener's granulomatosis effectively treated with early plasma exchange therapy.
We present a case of a 38-year-old Japanese man with Wegener's granulomatosis complicated with pulmonary-renal syndrome, i.e., diffuse pulmonary hemorrhage and rapidly progressive renal glomerulonephritis. As this is a life-threatening condition, we promptly initiated plasma exchange with intravenous methylprednisolone therapy. Diffuse pulmonary hemorrhage and renal failure were markedly improved. This case merits presentation because there are few clinical studies of the treatment of Wegener's granulomatosis with pulmonary-renal syndrome, particularly with pulmonary hemorrhage.
Sugimoto
Toshiro
T
Department of Medicine, Shiga University of Medical Science, Otsu. toshiro@belle.shiga-med.ac.jp
Deji
Naoko
N
Kume
Shinji
S
Osawa
Norihisa
N
Sakaguchi
Masayoshi
M
Isshiki
Keiji
K
Koya
Daisuke
D
Kashiwagi
Atsunori
A
D000328:Adult; D005921:Glomerulonephritis / Q000175:diagnosis / Q000209:etiology / Q000628:therapy*; D005938:Glucocorticoids / Q000627:therapeutic use; D014890:Granulomatosis with Polyangiitis / Q000150:complications / Q000175:diagnosis / Q000628:therapy*; D006470:Hemorrhage / Q000175:diagnosis / Q000209:etiology / Q000628:therapy*; D006801:Humans; D008171:Lung Diseases / Q000175:diagnosis / Q000209:etiology / Q000628:therapy*; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D010951:Plasma Exchange / Q000379:methods*; D013577:Syndrome
D005938:Glucocorticoids; D008775:Methylprednisolone