HIV-hepatitis C virus co-infection is associated with decreased plasmatic IL-7 levels.
We analysed the potential influence of hepatitis C virus (HCV) co-infection over IL-7 levels and thymic function in naive HIV-infected patients and after effective HAART. HIV-HCV-co-infected patients had lower plasmatic IL-7 levels compared with HIV-monoinfected patients. This effect may not be associated either with HCV monoinfection or with the rate of liver injury. These lower levels may explain, at least partly, the lower CD4 cell repopulation of HIV-HCV-co-infected patients after HAART.
Soriano-Sarabia
Natalia
N
Viral Hepatitis and AIDS Unit, Spain.
Vallejo
Alejandro
A
Molina-Pinelo
Sonia
S
Genebat
Miguel
M
del Mar Rodríguez
María
M
Sánchez-Quijano
Armando
A
Martínez-Moya
Manuel
M
Vivancos
Jorge
J
Leal
Manuel
M
D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy / Q000276:immunology*; D019698:Hepatitis C, Chronic / Q000150:complications / Q000276:immunology*; D006801:Humans; D015851:Interleukin-7 / Q000097:blood*; D008297:Male
D015851:Interleukin-7