title: Structure determination of an organometallic 1-(diazenylaryl)ethanol: a novel toxin subclass from the web of the spider Nephila clavipes.
abstract: A novel chemical subclass of toxin, [1-(3-diazenylphenyl)ethanol]iron, was identified among the compounds present in the web of the spider Nephila clavipes. This type of compound is not common among natural products, mainly in spider-venom toxins; it was shown to be a potent paralytic and/or lethal toxin applied by the spider over its web to ensure prey capture only by topical application. The structure was elucidated by means of ESI mass spectrometry, 1H-NMR spectroscopy, high-resolution (HR) mass spectrometry, and ICP spectrometry. The structure of [1-(3-diazenylphenyl)ethanol]iron and the study of its insecticidal action may be used as a starting point for the development of new drugs for pest control in agriculture.
authors.affiliation: Department of Biology, CEIS, Lab. Structural Biology and Zoochemistry, Institute of Biosciences, São Paulo State University (UNESP), Rio Claro, SP-13506-900, Brazil.
authors.forename: Maurício Ribeiro
authors.initials: MR
authors.lastname: Marques
authors.forename: Maria Anita
authors.initials: MA
authors.lastname: Mendes
authors.forename: Cláudio Francisco
authors.initials: CF
authors.lastname: Tormena
authors.forename: Bibiana M
authors.initials: BM
authors.lastname: Souza
authors.forename: Susan P
authors.initials: SP
authors.lastname: Ribeiro
authors.forename: Roberto
authors.initials: R
authors.lastname: Rittner
authors.forename: Mario S
authors.initials: MS
authors.lastname: Palma
mesh_terms: D000818:Animals; D000431:Ethanol / Q000737:chemistry* / Q000302:isolation & purification; D005290:Ferric Compounds / Q000737:chemistry* / Q000145:classification / Q000302:isolation & purification; D013111:Spider Venoms / Q000737:chemistry* / Q000145:classification* / Q000302:isolation & purification; D013112:Spiders / Q000737:chemistry*; D013329:Structure-Activity Relationship
chemical_list: D005290:Ferric Compounds; D013111:Spider Venoms; D000431:Ethanol