Effect of ophthalmic solution components on acrylic intraocular lenses.
OBJECTIVE
To investigate the effect of ophthalmic solution components on the surface of acrylic intraocular lenses (IOLs).


METHODS
Department of Opthalmology, Showa University School of Medicine.


METHODS
Measurement of the contact angles of ophthalmic solutions on 3 acrylic IOLs was performed. The solutions were diclofenac sodium (Diclod), bromfenac sodium (Bronuck), betamethasone phosphate (Rinderon), dibekacin sulfate (Panimycin), polysorbate 80 (Tween 20), benzalkonium chloride, chlorobutanol, methylparahydroxybenzoate, and propylparahydroxybenzoate. The IOLs were incubated at 35 degrees C for 2 weeks in undiluted ophthalmic solutions and in 1:10 dilutions of ophthalmic solution components. The IOLs were sectioned and observed by scanning electron microscopy.


RESULTS
The contact angle of Diclod and Bronuck solutions was the smallest. The contact angle of Rinderon and Panimycin was similar to that of distilled water. Scanning electron microscopy examination of IOLs incubated in ophthalmic solution components showed intralenticular changes. The IOLs immersed in ophthalmic solutions did not show any change, even after extended incubation.


CONCLUSIONS
The chemical components of ophthalmic solutions, such as surfactants and solvents, permeate acrylic IOLs, suggesting the potential for long-term adverse effects of eyedrops in pseudophakic eyes.
Ayaki
Masahiko
M
Department of Ophthalmology, Showa University School of Medicine, Tokyo, Japan. mayaki@olive.ocn.ne.jp
Nishihara
Hitoshi
H
Yaguchi
Shigeo
S
Koide
Ryohei
R
D000180:Acrylic Resins; D001577:Benzophenones / Q000494:pharmacology; D001623:Betamethasone / Q000494:pharmacology; D001969:Bromobenzenes / Q000494:pharmacology; D003982:Dibekacin / Q000494:pharmacology; D004008:Diclofenac / Q000494:pharmacology; D007910:Lenses, Intraocular; D008855:Microscopy, Electron, Scanning; D009883:Ophthalmic Solutions / Q000494:pharmacology*; D012997:Solvents / Q000494:pharmacology*; D013501:Surface-Active Agents / Q000494:pharmacology*
D000180:Acrylic Resins; D001577:Benzophenones; D001969:Bromobenzenes; D009883:Ophthalmic Solutions; D012997:Solvents; D013501:Surface-Active Agents; D004008:Diclofenac; D003982:Dibekacin; C053083:bromfenac; D001623:Betamethasone