Talosins A and B: new isoflavonol glycosides with potent antifungal activity from Kitasatospora kifunensis MJM341. II. Physicochemical properties and structure determination.
In our screening program for new antifungal agents from microbial secondary metabolites, two new isoflavonol glycosides, with potent antifungal activity, talosins A and B, were isolated from the culture broth of Kitasatospora kifunensis MJM341. Talosins A and B were determined to be genistein 7-alpha-L-6-deoxy-talopyranoside and genistein 4',7-di-alpha-L-6-deoxy-talopyranoside, respectively, by spectroscopic studies. They are the first flavonoid glycosides incorporating 6-deoxy-talose as a sugar component.
Kim
Won-Gon
WG
Korea Research Institute of Bioscience and Biotechnology, P.O. Box 115, Yuseong-Gu, Daejeon, 305-600, Korea.
Yoon
Tae Mi
TM
Kwon
Hyung Jin
HJ
Suh
Joo Won
JW
D000935:Antifungal Agents / Q000737:chemistry*; D006027:Glycosides / Q000737:chemistry*; D007529:Isoflavones / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D013306:Streptomycetaceae / Q000737:chemistry*
D000935:Antifungal Agents; D006027:Glycosides; D007529:Isoflavones; C516692:genistein 4',7'-bis(6-deoxytalopyranoside); C516691:genistein 7-(6-deoxytalopyranoside)