title: Neurodevelopmental origins of depressive disorders.
abstract: Depression is a common and devastating neuropsychiatric disorder, and a better understanding of its pathophysiology is needed to improve diagnosis, treatment and prevention. By considering the developmental dimensions of genetic and environmental factors, new insights have been found into the etiology and pathophysiology of depression. Specifically, we begin to understand how certain vulnerability factors affect the maturation of brain circuits involved in emotional function to increase the risk for depressive disorders later in life. These new findings might help us to better categorize and manage this complex disease.
authors.affiliation: Sackler Institute Laboratories, Department of Psychiatry, Columbia University and the New York State Psychiatric Institute, New York, NY 10032, USA.
authors.forename: Mark S
authors.initials: MS
authors.lastname: Ansorge
authors.forename: René
authors.initials: R
authors.lastname: Hen
authors.forename: Jay A
authors.initials: JA
authors.lastname: Gingrich
mesh_terms: D000818:Animals; D015306:Biogenic Monoamines / Q000378:metabolism; D003863:Depression / Q000209:etiology* / Q000378:metabolism / Q000503:physiopathology; D003866:Depressive Disorder / Q000209:etiology* / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology; D009414:Nerve Growth Factors / Q000378:metabolism; D010913:Pituitary-Adrenal System / Q000503:physiopathology
chemical_list: D015306:Biogenic Monoamines; D009414:Nerve Growth Factors