title: Psychological and cognitive functioning in children and adolescents with congenital heart disease: a meta-analysis.
abstract: OBJECTIVE
  Findings in the literature are inconsistent on the impact of congenital heart disease (CHD) on the psychological and cognitive functioning of children and adolescents. The aim of the present study was to systematically review this empirical body of literature.
  
  
  METHODS
  We conducted a meta-analysis to review studies on behavior problems and cognitive functioning in CHD.
  
  
  RESULTS
  Only older children and adolescents with CHD displayed an increased risk of overall, internalizing, and to a lesser extent externalizing behavior problems. In addition, patients with severe CHD exhibited lower cognitive functioning than patients with less severe CHD, specifically with respect to performance intelligence. Moreover, decreased cognitive functioning remained relatively stable across different age groups.
  
  
  CONCLUSIONS
  Children with severe heart disease may benefit from interventions specifically targeting perceptual organizational abilities, such as visual-spatial abilities. Moreover, older children and adolescents with CHD may benefit from psychological interventions reducing anxiety symptoms and depression.
authors.affiliation: University of Amsterdam, The Netherlands. P.Karsdorp@DMKEP.unimaas.nl
authors.forename: Petra A
authors.initials: PA
authors.lastname: Karsdorp
authors.forename: Walter
authors.initials: W
authors.lastname: Everaerd
authors.forename: Merel
authors.initials: M
authors.lastname: Kindt
authors.forename: Barbara J M
authors.initials: BJ
authors.lastname: Mulder
mesh_terms: D000293:Adolescent; D001007:Anxiety / Q000175:diagnosis / Q000209:etiology* / Q000523:psychology*; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease / Q000523:psychology; D003072:Cognition Disorders / Q000175:diagnosis / Q000453:epidemiology*; D005260:Female; D006330:Heart Defects, Congenital / Q000453:epidemiology* / Q000523:psychology*; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D012720:Severity of Illness Index