PDMS absorption of small molecules and consequences in microfluidic applications.
Microfluidic devices made out of polydimethylsiloxane (PDMS) have many physical properties that are useful for cell culture applications, such as transparency and gas permeability. Another distinct characteristic of PDMS is its ability to absorb hydrophobic small molecules. Partitioning of molecules into PDMS can significantly change solution concentrations and could potentially alter experimental outcomes. Herein we discuss PDMS absorption and its potential impact on microfluidic experiments.
Toepke
Michael W
MW
Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI 53706, USA.
Beebe
David J
DJ
D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004129:Dimethylpolysiloxanes / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D044085:Microfluidics / Q000379:methods*; D008856:Microscopy, Fluorescence / Q000379:methods; D010078:Oxazines / Q000737:chemistry; D010316:Particle Size; D016062:Porosity; D011803:Quinine / Q000737:chemistry*; D012680:Sensitivity and Specificity; D012828:Silicones / Q000737:chemistry*; D013499:Surface Properties; D014867:Water / Q000737:chemistry
D004129:Dimethylpolysiloxanes; D010078:Oxazines; D012828:Silicones; D014867:Water; C013830:baysilon; D011803:Quinine; C044808:nile red