[Influence of the soybean flavonoid supplement on the synthesis of nitric oxide (NO) in the patients with atherosclerosis].
66 patients of 40-77 age group with atherosclerosis were studied. The observation period made up 4 weeks. The patients were divided into two groups. Group I- experimental group (50 patients) and group II-control group (16 patients) The patients of both groups were given standard therapy, but the patients of group I were additionally given 200mg soybean flavonoid supplement (daily dose 100mg. in capsules two times a day after meals). Clinical observation showed that the patients had no adverse reactions due to intake of the natural food supplement. Compared to the control patients better dynamics of clinical signs was observed in experimental group: reduction of chest pain intensity, arrhythmia and breathlessness, increase of tolerance to physical load, manifested of normalisation arterial hypertension and reduction of heart rate. Biochemical analysis showed an antiatherogenic and hypolipidemic effect of the soybean flavonoid supplement. Statistically reliable increase of NO; reduction of general peripherial vascular resistance and improvement of systolic function. Therefore it can be concluded that given biologically active supplement can be used in the treatment of atherosclerosis as an effective therapeutic tool.
Chaava
Kh M
KhM
Kapetivadze
V I
VI
Tabukashvili
R I
RI
Grigorashvili
G Z
GZ
Kapetivadze
I G
IG
D000328:Adult; D000368:Aged; D050197:Atherosclerosis / Q000097:blood / Q000178:diet therapy / Q000503:physiopathology; D004044:Dietary Proteins / Q000627:therapeutic use*; D019587:Dietary Supplements; D015150:Echocardiography, Doppler; D004578:Electron Spin Resonance Spectroscopy; D005260:Female; D005419:Flavonoids / Q000627:therapeutic use*; D005500:Follow-Up Studies; D006352:Heart Ventricles / Q000000981:diagnostic imaging / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction / Q000187:drug effects; D009569:Nitric Oxide / Q000096:biosynthesis* / Q000097:blood; D030262:Soybean Proteins / Q000627:therapeutic use*; D016896:Treatment Outcome; D014655:Vascular Resistance / Q000187:drug effects
D004044:Dietary Proteins; D005419:Flavonoids; D030262:Soybean Proteins; D009569:Nitric Oxide