title: Isolation and characterisation of a phenolic impurity in a commercial sample of duloxetine.
abstract: A phenolic impurity of duloxetine hydrochloride was isolated and characterised (MS, NMR, X-ray-analysis).
authors.affiliation: Dipartimento di Chimica, Materiali, Ingegneria Chimica, Politecnico di Milano, ed Istituto CNR per la Chimica del Riconoscimento Molecolare, Via Mancinelli 7, I-20131 Milano, Italy. elisabetta.brenna@polimi.it
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Brenna
authors.forename: Samuele
authors.initials: S
authors.lastname: Frigoli
authors.forename: Giovanni
authors.initials: G
authors.lastname: Fronza
authors.forename: Claudio
authors.initials: C
authors.lastname: Fuganti
authors.forename: Luciana
authors.initials: L
authors.lastname: Malpezzi
mesh_terms: D004340:Drug Contamination; D000068736:Duloxetine Hydrochloride; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry / Q000379:methods; D015394:Molecular Structure; D019800:Phenol / Q000032:analysis / Q000737:chemistry / Q000302:isolation & purification*; D017367:Selective Serotonin Reuptake Inhibitors / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization; D013876:Thiophenes / Q000737:chemistry*
chemical_list: D000068736:Duloxetine Hydrochloride; D019800:Phenol; D017367:Selective Serotonin Reuptake Inhibitors; D013876:Thiophenes