Trapping transient protein-protein interactions in polyketide biosynthesis.
Transient biomolecular interactions are essential for biological processes, but strategies for studying them have remained elusive. A paper in this issue shows how natural enzymatic activities can be exploited to examine protein-protein interactions in fatty acid synthase.
Schnarr
Nathan A
NA
Department of Chemistry, Stanford University, Stanford, California 94305, USA.
Khosla
Chaitan
C
D002616:Chemical Engineering / Q000379:methods; D003432:Cross-Linking Reagents / Q000138:chemical synthesis; D018942:Macrolides / Q000378:metabolism*; D048630:Polyketide Synthases / Q000096:biosynthesis; D025941:Protein Interaction Mapping / Q000379:methods*
D003432:Cross-Linking Reagents; D018942:Macrolides; D048630:Polyketide Synthases