Association of the maternal 14-bp insertion polymorphism in the HLA-G gene in women with recurrent spontaneous abortions.
Human leukocyte antigen (HLA)-G has been postulated as an important immunotolerant molecule in maintaining fetal-maternal relationship. Recent reports indicated that the 14-bp deletion/insertion polymorphism in exon 8 of HLA-G gene influences HLA-G mRNA stability and isoform splicing patterns, thus modulating the levels of HLA-G expression. This might play an immunomodulatory role of HLA-G during implantation and pregnancy. In the present study, 109 unrelated fertile control women and 79 women who had experienced recurrent spontaneous abortion (RSA) were genotyped for the 14-bp insertion/deletion polymorphism. No significant difference was observed in the distribution of 14-bp insertion/deletion genotype between controls and the RSA group. However, a greater number of 14-bp insertion alleles exist in the RSA group than in the controls.
Yan
W H
WH
Medical Research Center, Taizhou Hospital of Zhejiang Province, Wenzhou Medical College, Linhai, Zhejiang, People's Republic of China. yanwhcom@yahoo.com
Lin
A
A
Chen
X J
XJ
Dai
M Z
MZ
Gan
L H
LH
Zhou
M Y
MY
Zhu
M
M
Shi
W W
WW
Liu
J M
JM
D000026:Abortion, Habitual / Q000175:diagnosis / Q000235:genetics* / Q000276:immunology; D000483:Alleles; D005260:Female; D005838:Genotype; D006680:HLA Antigens / Q000032:analysis / Q000235:genetics*; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I / Q000032:analysis / Q000235:genetics*; D006801:Humans; D011110:Polymorphism, Genetic; D011247:Pregnancy; D020871:RNA Stability; D012333:RNA, Messenger / Q000378:metabolism
D006680:HLA Antigens; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I; D012333:RNA, Messenger