Apparent mineralocorticoid excess manifested in an elderly patient with hypothyroidism.
The syndrome of apparent mineralocorticoid excess (AME) is characterized by persistent hypertension and hypokalemia, which is caused by impaired inactivation of cortisol (F) to cortisone (E). The thyroid hormone has been known to influence the F to E conversion leading to efficacious inactivation of F into E. However, there have been no reports regarding the clinical manifestation of secondary AME due to hypothyroidism. Here we report an elderly patient who manifested AME, showing persistent hypertension with hypokalemia induced by primary hypothyroidism. Maintenance of euthyroid conditions ameliorated the concurrent AME and restored adrenal secretion of aldosterone after the recovery of the F to E shuttle. This case report would broaden our clinical recognition regarding acquired AME in relation to thyroid dysfunction.
Inagaki
Kenichi
K
Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Okayama City 700-8558, Japan.
Otsuka
Fumio
F
Otani
Hiroyuki
H
Sato
Chikage
C
Miyoshi
Tomoko
T
Ogura
Toshio
T
Makino
Hirofumi
H
D000369:Aged, 80 and over; D000450:Aldosterone / Q000097:blood; D005260:Female; D006801:Humans; D006973:Hypertension / Q000209:etiology; D007008:Hypokalemia / Q000209:etiology; D007037:Hypothyroidism / Q000150:complications* / Q000188:drug therapy; D043204:Mineralocorticoid Excess Syndrome, Apparent / Q000188:drug therapy / Q000209:etiology*
D000450:Aldosterone