CD8 T-cell subsets and viral load in the cerebrospinal fluid of therapy-naive HIV-infected individuals.
Central nervous system involvement is common in HIV infection. We determined the relationship between T-cell subsets and viral load in the cerebrospinal fluid (CSF) of therapy-naive, asymptomatic HIV-infected individuals. A shift from naive to effector-memory CD8 T cells was observed in the CSF of HIV-infected individuals compared with controls. The HIV load strongly correlated with CD8 T cells in CSF. Effector-memory CD8 T cells were positively and effector CD8 T cells were negatively associated with viral replication in CSF.
von Geldern
Gloria
G
Department of Neurology, Germany.
Cepok
Sabine
S
Nolting
Thorsten
T
Du
Yihua
Y
Grummel
Verena
V
Adams
Ortwin
O
Hartung
Hans-Peter
HP
Arendt
Gabriele
G
Hemmer
Bernhard
B
D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D015658:HIV Infections / Q000134:cerebrospinal fluid / Q000276:immunology* / Q000821:virology; D015497:HIV-1 / Q000302:isolation & purification*; D006801:Humans; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D019562:Viral Load