title: Dengue hemorrhagic Fever caused by sequential dengue 1-3 virus infections over a long time interval: Havana epidemic, 2001-2002.
abstract: A dengue epidemic caused by dengue virus 3 (DENV-3) occurred in Cuba in 2001-2002. It included cases of dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS). We report neutralizing antibody studies on sera from 54 of 78 DHF/DSS patients that provide evidence of infections occurring in the sequence DENV-1 followed by DENV-3. No sera showed infection in the sequence DENV-2 followed by DENV-3. Some sera showed a pattern of infection in the sequence DENV-1 followed by DENV-2 and then DENV-3. However definitive categorization of a tertiary infection was not possible because of broadly reactive antibodies, which could have been raised by infections in the sequence DENV-1 then DENV-3.
authors.affiliation: Department of Virology, Pan American Health Organization/World Health Organization Collaborating Center for the Study of Dengue and Its Vector, Pedro Kourí Tropical Medicine Institute, Havana, Cuba.
authors.forename: Mayling
authors.initials: M
authors.lastname: Alvarez
authors.forename: Rosmari
authors.initials: R
authors.lastname: Rodriguez-Roche
authors.forename: Lídice
authors.initials: L
authors.lastname: Bernardo
authors.forename: Susana
authors.initials: S
authors.lastname: Vázquez
authors.forename: Luis
authors.initials: L
authors.lastname: Morier
authors.forename: Daniel
authors.initials: D
authors.lastname: Gonzalez
authors.forename: Osvaldo
authors.initials: O
authors.lastname: Castro
authors.forename: Gustavo
authors.initials: G
authors.lastname: Kouri
authors.forename: Scott B
authors.initials: SB
authors.lastname: Halstead
authors.forename: Maria G
authors.initials: MG
authors.lastname: Guzman
mesh_terms: D000914:Antibodies, Viral / Q000097:blood; D003462:Cuba / Q000453:epidemiology; D003716:Dengue Virus / Q000145:classification / Q000302:isolation & purification; D006801:Humans; D009500:Neutralization Tests; D019595:Severe Dengue / Q000453:epidemiology*; D013997:Time Factors
chemical_list: D000914:Antibodies, Viral