Increased incidence of cytomegalovirus retinitis after allogeneic hematopoietic stem cell transplantation.
Six cases of cytomegalovirus retinitis (CMVR) after allogeneic hematopoietic stem cell transplantation were diagnosed between 2002 and 2005 in our center, whereas only one case was diagnosed between 1985 and 2001. Cumulative incidence reaches 2.2%, whereas this complication has been rarely described after hematopoietic stem cell transplantation. We aimed to describe clinical and biologic features of CMVR and search for risk factors associated with CMVR. CMVR was diagnosed on specific funduscopic examination in all patients either on visual symptoms (n=3) or on systematic ophthalmologic examination (n=3). CMVR occurred in the context of unrelated transplantation in patients with profound immune defect and multiple episodes of cytomegalovirus (CMV) reactivation. The combination of a CMV-seropositive recipient and CMV-seronegative donor was the leading risk factor.
Xhaard
Aliénor
A
Service d'Hématologie-Transplantation, Hôpital Saint-Louis, Paris, France.
Robin
Marie
M
Scieux
Catherine
C
de Latour
Régis Peffault
RP
Deplus
Sylvie
S
Mazeron
Marie-Christine
MC
Devergie
Agnès
A
Espérou
Hélène
H
Rocha
Vanderson
V
Gluckman
Eliane
E
Ribaud
Patricia
P
Socié
Gérard
G
D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use*; D002675:Child, Preschool; D017726:Cytomegalovirus Retinitis / Q000453:epidemiology*; D024882:Drug Resistance, Viral; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D015994:Incidence; D012189:Retrospective Studies
D000998:Antiviral Agents