title: Pulmonary vascular abnormalities in cirrhosis.
abstract: Two pulmonary vascular disorders can occur in liver disease and/or portal hypertension: the hepatopulmonary syndrome (HPS), which is characterized by intrapulmonary vascular dilatations, and portopulmonary hypertension (POPH), in which pulmonary vascular resistance is elevated. POPH and HPS are characterized by distinct pulmonary microvascular remodelling, which occurs at different anatomical sites of the pulmonary microcirculation. The exact pathophysiological mechanisms of these pulmonary vascular disorders are unknown. However, as HPS and POPH have been reported in patients with extrahepatic portal hypertension, the factor that determines their development must be portal hypertension. The clinical presentations are very different, with gas exchange impairment in HPS and hemodynamic failure in POPH. The severity of HPS seems to parallel the severity of liver failure, whereas no simple relationship has been identified between hepatic impairment and the severity of POPH. Resolution of HPS is common after liver transplantation, which has an uncertain effect in POPH.
authors.affiliation: National French Reference Centre for Pulmonary Arterial Hypertension, UPRES EA 2705, Service de Pneumologie et Réanimation Respiratoire, Hôpital Antoine Béclère, Assistance Publique-Hôpitaux de Paris, Université Paris-Sud, Clamart, France. pherve@ccml.com
authors.forename: Philippe
authors.initials: P
authors.lastname: Herve
authors.forename: Jerome
authors.initials: J
authors.lastname: Le Pavec
authors.forename: Benjamin
authors.initials: B
authors.lastname: Sztrymf
authors.forename: Benoit
authors.initials: B
authors.lastname: Decante
authors.forename: Laurent
authors.initials: L
authors.lastname: Savale
authors.forename: Olivier
authors.initials: O
authors.lastname: Sitbon
mesh_terms: D003937:Diagnosis, Differential; D020065:Hepatopulmonary Syndrome / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy*; D006801:Humans; D006975:Hypertension, Portal / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy*; D006976:Hypertension, Pulmonary / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy*; D008103:Liver Cirrhosis / Q000150:complications*; D016031:Liver Transplantation; D016896:Treatment Outcome