Endogenous Alkaloids in Man - Synthesis, Analytics, in vivo Identification, and Medicinal Importance*,1.
The IN VITRO and IN VIVO condensation of endogenous (or administered) reactive amines and carbonyl compounds is reported, leading to alkaloid-type heterocycles. The spectrum of the presented "mammalian alkaloids" ranges from isoquinoline derivatives, via beta-carbolines, through to thiazolidines, arising from vitamin B (6), chloral, and glyoxylic acid, respectively. Formation of these compounds may occur accidentally, but might also be induced intentionally, as a therapy for metabolic diseases.
Bringmann
G
G
Institute of Organic Chemistry, University of Würzburg, Am Hubland, D-8700 Würzburg, Federal Republic of Germany.
Feineis
D
D
Friedrich
H
H
Hille
A
A