Osler-Weber-Rendu syndrome as a cause of poor growth during adolescence.
We report an adolescent boy with poor growth and delayed skeletal age who was found to have pulmonary arteriovenous malformations (PAVMs) consistent with hereditary hemorrhagic telangiectasia (Osler-Weber-Rendu syndrome). While a host of chronic diseases, including a number of cardiopulmonary diseases, have previously been associated with poor growth or short stature, to our knowledge this is the first documented case of PAVM presenting with poor growth, manifesting as weight loss and delayed adolescence. This case highlights the importance of a thorough physical examination for identifying rare, occult, chronic diseases in patients who present with poor growth.
Fleisch
Abby F
AF
Unit on Growth and Obesity, Developmental Endocrinology Branch, NICHD, NIH, Bethesda, MD 20892-1103, USA.
Ning
Cong
C
Yanovski
Jack A
JA
D000293:Adolescent; D001165:Arteriovenous Malformations / Q000209:etiology; D006130:Growth Disorders / Q000209:etiology* / Q000503:physiopathology; D006801:Humans; D008168:Lung / Q000098:blood supply; D008297:Male; D013683:Telangiectasia, Hereditary Hemorrhagic / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology; D015431:Weight Loss / Q000502:physiology