title: Bypassing translation initiation.
abstract: A high-resolution cryo-EM reconstruction of a ribosome-bound dicistrovirus IRES (Schüler et al., 2006) and the crystal structure of its ribosome binding domain (Pfingsten et al., 2006) provide new insights into an exceptional eukaryotic translation mechanism.
authors.affiliation: Department of Microbiology and Immunology, State University of New York Downstate Medical Center, Brooklyn, NY 11203, USA. christopher.hellen@downstate.edu
authors.forename: Christopher U T
authors.initials: CU
authors.lastname: Hellen
mesh_terms: D020285:Cryoelectron Microscopy; D018360:Crystallography, X-Ray; D010442:Peptide Chain Initiation, Translational; D017434:Protein Structure, Tertiary; D012328:RNA Viruses / Q000737:chemistry / Q000648:ultrastructure; D012333:RNA, Messenger / Q000737:chemistry* / Q000648:ultrastructure; D022661:RNA, Untranslated / Q000737:chemistry / Q000648:ultrastructure; D012270:Ribosomes / Q000737:chemistry* / Q000648:ultrastructure
chemical_list: D012333:RNA, Messenger; D022661:RNA, Untranslated