title: Metallo-beta-lactamases as emerging resistance determinants in Gram-negative pathogens: open issues.
abstract: The rapid spread of acquired metallo-beta-lactamases (MBLs) among major Gram-negative pathogens is a matter of particular concern worldwide and primarily in Europe, one of first continents where the emergence of acquired MBLs has been reported and possibly the geographical area where the increasing diversity of these enzymes and the number of bacterial species affected are most impressive. This spread has not been paralleled by accuracy/standardisation of detection methods, completeness of epidemiological knowledge or a clear understanding of what MBL production entails in terms of clinical impact, hospital infection control and antimicrobial chemotherapy. A number of European experts in the field met to review the current knowledge on this phenomenon, to point out open issues and to reinforce and relate to one another the existing activities set forth by research institutes, scientific societies and European Union-driven networks.
authors.affiliation: Department of Pathology, University of Verona, Italy. giuseppe.cornaglia@univr.it
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Cornaglia
authors.forename: Murat
authors.initials: M
authors.lastname: Akova
authors.forename: Gianfranco
authors.initials: G
authors.lastname: Amicosante
authors.forename: Rafael
authors.initials: R
authors.lastname: Cantón
authors.forename: Roberto
authors.initials: R
authors.lastname: Cauda
authors.forename: Jean-Denis
authors.initials: JD
authors.lastname: Docquier
authors.forename: Mikhail
authors.initials: M
authors.lastname: Edelstein
authors.forename: Jean-Marie
authors.initials: JM
authors.lastname: Frère
authors.forename: Miklós
authors.initials: M
authors.lastname: Fuzi
authors.forename: Moreno
authors.initials: M
authors.lastname: Galleni
authors.forename: Helen
authors.initials: H
authors.lastname: Giamarellou
authors.forename: Marek
authors.initials: M
authors.lastname: Gniadkowski
authors.forename: Raffaella
authors.initials: R
authors.lastname: Koncan
authors.forename: Balázs
authors.initials: B
authors.lastname: Libisch
authors.forename: Francesco
authors.initials: F
authors.lastname: Luzzaro
authors.forename: Vivi
authors.initials: V
authors.lastname: Miriagou
authors.forename: Ferran
authors.initials: F
authors.lastname: Navarro
authors.forename: Patrice
authors.initials: P
authors.lastname: Nordmann
authors.forename: Laura
authors.initials: L
authors.lastname: Pagani
authors.forename: Luisa
authors.initials: L
authors.lastname: Peixe
authors.forename: Laurent
authors.initials: L
authors.lastname: Poirel
authors.forename: Maria
authors.initials: M
authors.lastname: Souli
authors.forename: Evelina
authors.initials: E
authors.lastname: Tacconelli
authors.forename: Alkiviadis
authors.initials: A
authors.lastname: Vatopoulos
authors.forename: Gian Maria
authors.initials: GM
authors.lastname: Rossolini
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D024901:Drug Resistance, Multiple, Bacterial; D005062:European Union; D006090:Gram-Negative Bacteria / Q000145:classification / Q000187:drug effects / Q000302:isolation & purification* / Q000502:physiology*; D016905:Gram-Negative Bacterial Infections / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology* / Q000517:prevention & control; D006801:Humans; D008826:Microbial Sensitivity Tests; D018440:beta-Lactam Resistance; D001618:beta-Lactamases / Q000187:drug effects / Q000502:physiology*
chemical_list: D000900:Anti-Bacterial Agents; D001618:beta-Lactamases