Treatment and prevention of enteric infections with toxin-binding probiotics.
Nearly all antibiotics aim at killing the bacteria, which eventually develop antibiotic resistance under "survival pressure." The pathology exerted by many pathologic bacteria is through secreting toxins. Probiotics, either harmless live bacteria or dead ones, can be molecularly engineered to express receptors for the toxins and absorb and eliminate them from binding to their natural receptors, thus reducing or eliminating the pathological impact of bacterial infection.
Paton
Adrienne W
AW
School of Molecular and Biomedical Science, University of Adelaide, S.A., 5005, Australia.
Morona
Renato
R
Paton
James C
JC
D000818:Animals; D001424:Bacterial Infections / Q000188:drug therapy* / Q000517:prevention & control*; D001427:Bacterial Toxins / Q000378:metabolism*; D005767:Gastrointestinal Diseases / Q000188:drug therapy* / Q000382:microbiology / Q000517:prevention & control*; D006801:Humans; D008954:Models, Biological; D019936:Probiotics / Q000378:metabolism* / Q000627:therapeutic use*
D001427:Bacterial Toxins