title: [Diuretic effect of injecting furosemide into low hydraulic resistance point Shuifen along the conception meridian in pigs with acute edema].
abstract: OBJECTIVE
  To observe whether injection of medicine into low hydraulic resistance point along meridian brings about higher medicinal effect and to explore the efficacy of the theory that meridians are made up of channels featuring low hydraulic resistance by observing the diuretic effect of injecting furosemide or saline into the low hydraulic resistance point Shuifen (CV 9), vein and Zusanli (St 36) respectively.
  
  
  METHODS
  Acute edema was induced in pigs by rapid intravenous injection of 2 000 ml normal saline. The pigs were divided into four groups: Shuifen (CV 9) injection of half dose furosemide group (SFF group), intravenous injection of full dose furosemide group (VF group), Zusanli (St 36) injection of full dose furosemide group (ZSLF group), and Shuifen (CV 9) injection of half dose normal saline group (SFS group). The accumulated urine quantity and the urine quantity generated in every 15-minute period were measured in each group respectively, every 15 minutes after injection, and the measurement lasted for two hours at one experiment. Each group involved eight times of experiments with one pig used for one experiment, which means the whole observation involved 32 times of experiments.
  
  
  RESULTS
  The accumulated urine quantities observed in both SFF group and VF group were higher than those in the ZSLF group and the SFS group all through the measurement, showing significant differences during the period from the 15th minute to the 45th minute (P<0.05). But no significant difference was observed between the SFF group and the VF group during the whole 2-hour measurement (P>0.05). Analysis of urine quantity generated in every 15-minute period showed that diuretic effect climaxed during the 15th minute to the 30th minute in both SFF group and VF group. By contrast, ZSLF group reached diuresis climax during the 45th minute to 60th minute and no diuresis climax was observed in the SFS group all through the measurement.
  
  
  CONCLUSIONS
  Injection of medicine into low hydraulic resistance point along meridian generates faster and more powerful medicinal potency, and this is likely to be applied to clinical practice. The theory that meridians are channels featuring low hydraulic resistance is important to the elucidation of meridians.
authors.affiliation: Department of Acupuncture, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China.
authors.forename: Heng-hui
authors.initials: HH
authors.lastname: Xie
authors.forename: Wei-bo
authors.initials: WB
authors.lastname: Zhang
authors.forename: Yu-ying
authors.initials: YY
authors.lastname: Tian
authors.forename: Hong
authors.initials: H
authors.lastname: Li
authors.forename: Shi-zhe
authors.initials: SZ
authors.lastname: Gu
mesh_terms: D015669:Acupuncture Points; D000208:Acute Disease; D000818:Animals; D004232:Diuretics / Q000008:administration & dosage*; D004487:Edema / Q000628:therapy* / Q000652:urine; D005665:Furosemide / Q000008:administration & dosage*; D007267:Injections; D007275:Injections, Intravenous; D008297:Male; D016740:Meridians; D013552:Swine; D013556:Swine, Miniature; D014554:Urination / Q000187:drug effects
chemical_list: D004232:Diuretics; D005665:Furosemide