title: [Clinical assessment of potential fields of application of recombinant factor VIIa in internal and pediatric diseases. Recommendations of an expert group].
abstract: Recombinant factor VIIa (rFVIIa) is increasingly used outside the labeled indications for treatment of life-threatening bleeding episodes after failure of the respective standard therapy. An interdisciplinary group of experts summarizes the state of knowledge of the use of rFVIIa in gastroenterology and hepatology, thrombocytopenia and -pathia, coagulation factor deficiencies, von Willebrand's disease, periinterventional bleeding without specific bleeding diathesis, drug-induced bleeding, disseminated intravascular coagulation, and neonatology. The most commonly used dose is 90 microg/kg body weight rFVIIa as bolus, if necessary followed by additional injections at intervals of 2-3 h. In factor VII deficiency lower dosages of 15-30 microg/kg body weight of rFVIIa are given every 4-6 h, whereas higher doses of 150-200 microg/kg body weight are used in neonates.
authors.affiliation: Hämostaseologie, Klinikum Mannheim gGmbH, Mannheim.
authors.forename: Carl-Erik
authors.initials: CE
authors.lastname: Dempfle
authors.forename: Dietrich
authors.initials: D
authors.lastname: Gulba
authors.forename: Carl M
authors.initials: CM
authors.lastname: Kirchmaier
authors.forename: Robert
authors.initials: R
authors.lastname: Klamroth
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Korte
authors.forename: Reinhard
authors.initials: R
authors.lastname: Lorenz
authors.forename: Markus
authors.initials: M
authors.lastname: Peck-Radosavljevic
authors.forename: Alex
authors.initials: A
authors.lastname: Veldman
authors.forename: Rainer B
authors.initials: RB
authors.lastname: Zotz
mesh_terms: D000328:Adult; D002648:Child; D017277:Drug Approval; D019317:Evidence-Based Medicine; D005168:Factor VII Deficiency / Q000097:blood / Q000188:drug therapy*; D015942:Factor VIIa / Q000008:administration & dosage*; D005858:Germany; D006470:Hemorrhage / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D011994:Recombinant Proteins / Q000008:administration & dosage
chemical_list: D011994:Recombinant Proteins; D015942:Factor VIIa