Frizzled/PCP signalling: a conserved mechanism regulating cell polarity and directed motility.
Signalling through Frizzled (Fz)/planar cell polarity (PCP) is a conserved mechanism that polarizes cells along specific axes in a tissue. Genetic screens in Drosophila melanogaster pioneered the discovery of core PCP factors, which regulate the orientation of hairs on wings and facets in eyes. Recent genetic evidence shows that the Fz/PCP pathway is conserved in vertebrates and is crucial for disparate processes as gastrulation and sensory cell orientation. Fz/PCP signalling depends on complex interactions between core components, leading to their asymmetric distribution and ultimately polarized activity in a cell. Whereas several mechanistic aspects of PCP have been uncovered, the global coordination of this polarization remains debated.
Seifert
Jessica R K
JR
Brookdale Department of Molecular, Cell and Developmental Biology, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029, USA.
Mlodzik
Marek
M
D000818:Animals; D019521:Body Patterning / Q000235:genetics*; D002465:Cell Movement / Q000502:physiology*; D016764:Cell Polarity / Q000502:physiology*; D017124:Conserved Sequence / Q000235:genetics; D029721:Drosophila Proteins / Q000235:genetics*; D004331:Drosophila melanogaster / Q000235:genetics* / Q000502:physiology; D019143:Evolution, Molecular; D051157:Frizzled Receptors / Q000235:genetics*; D005786:Gene Expression Regulation / Q000235:genetics*; D043562:Receptors, G-Protein-Coupled / Q000235:genetics*; D015398:Signal Transduction / Q000235:genetics* / Q000502:physiology; D014714:Vertebrates / Q000235:genetics* / Q000502:physiology
D029721:Drosophila Proteins; D051157:Frizzled Receptors; D043562:Receptors, G-Protein-Coupled; C058784:fz protein, Drosophila