title: Successful neoadjuvant synchronous chemo- and radiotherapy for disseminated primary intracranial choriocarcinoma: case report.
abstract: We report a 17-year-old male with disseminated intracranial choriocarcinoma at the basal ganglia whose consciousness level was very low at diagnosis. He received neoadjuvant therapy (NAT) consisting of combined chemo- and radiotherapy prior to radical excision of the tumor. Postoperatively he was treated with three courses of high-dose chemotherapy (carboplatin (CBDCA), methotrexate (MTX), and etoposide (VP-16)) and peripheral blood stem-cell transplantation. This combination of therapies resulted in tumor regression on MRI and remarkable improvement in his neurological condition. Ours is the first report of the effectiveness of NAT followed by radical surgery in a patient with disseminated primary intracranial choriocarcinoma.
authors.affiliation: Department of Neurosurgery and Pediatrics, School of Medicine, The University of Tokushima, Kuramoto-cho 3-18-15, 770, Tokushima, Japan. kageji@clin.med.tokushima-u.ac.jp
authors.forename: Teruyoshi
authors.initials: T
authors.lastname: Kageji
authors.forename: Shinji
authors.initials: S
authors.lastname: Nagahiro
authors.forename: Kazuhito
authors.initials: K
authors.lastname: Matsuzaki
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Kanematsu
authors.forename: Minoru
authors.initials: M
authors.lastname: Nakatani
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Okamoto
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Watanabe
mesh_terms: D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001932:Brain Neoplasms / Q000097:blood / Q000188:drug therapy* / Q000532:radiotherapy* / Q000601:surgery; D016190:Carboplatin / Q000008:administration & dosage; D002822:Choriocarcinoma / Q000097:blood / Q000188:drug therapy* / Q000532:radiotherapy* / Q000601:surgery; D018997:Chorionic Gonadotropin, beta Subunit, Human / Q000097:blood; D003131:Combined Modality Therapy; D005047:Etoposide / Q000008:administration & dosage; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage; D020360:Neoadjuvant Therapy / Q000379:methods*; D036102:Peripheral Blood Stem Cell Transplantation; D016896:Treatment Outcome
chemical_list: D018997:Chorionic Gonadotropin, beta Subunit, Human; D005047:Etoposide; D016190:Carboplatin; D008727:Methotrexate