Pancreatitis-associated protein: from a lectin to an anti-inflammatory cytokine.
Pancreatitis-associated protein (PAP) was discovered in the pancreatic juice of rats with acute pancreatitis. PAP is a 16 kDa secretory protein structurally related to the C-type lectins although classical lectin-related function has not been reported yet. Then, it was demonstrated that PAP expression may be activated in some tissues in a constitutive or injury- and inflammation-induced manner. More recently, it has been found that PAP acts as an anti-inflammatory factor in vitro and in vivo. PAP expression can be induced by several pro- and anti-inflammatory cytokines and by itself through a JAK/STAT3-dependent pathway. PAP is able to activate the expression of the anti-inflammatory factor SOCS3 through the JAK/STAT3-dependent pathway. The JAK/STAT3/SOCS3 pathway seems to be a common point between PAP and several cytokines. Therefore, it is reasonable to propose that PAP is a new anti-inflammatory cytokine.
Closa
Daniel
D
Motoo
Yoshiharu
Y
Iovanna
Juan L
JL
D000818:Animals; D000951:Antigens, Neoplasm / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism*; D014408:Biomarkers, Tumor / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism*; D016207:Cytokines / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism*; D018836:Inflammation Mediators / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism*; D037102:Lectins / Q000737:chemistry; D037181:Lectins, C-Type / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism*; D010195:Pancreatitis / Q000235:genetics / Q000378:metabolism*; D000073718:Pancreatitis-Associated Proteins; D051381:Rats; D050796:STAT3 Transcription Factor / Q000378:metabolism
D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D016207:Cytokines; D018836:Inflammation Mediators; D037102:Lectins; D037181:Lectins, C-Type; D000073718:Pancreatitis-Associated Proteins; C000612141:REG3A protein, human; C000612144:Reg3b protein, rat; D050796:STAT3 Transcription Factor