title: Evaluation of ocular surface inflammation in the presence of dry eye and allergic conjunctival disease.
abstract: The ocular inflammatory diseases dry eye and allergic conjunctivitis are mediated by CD4+ T cells. Th1 cells secrete interferon (IFN)-gamma and are implicated in mediating the disease process in dry eye. Allergic conjunctivitis has been classically defined as a Th2 disease because of the predominance of Th2 cytokines interleukin (IL)-4 and IL-13. A multi-hit antigen challenge mouse model of allergic conjunctivitis provides evidence that IFN-gamma, a Th1 cytokine, acts as an endothelium gatekeeper by regulating endothelial expression of vascular adhesion molecule-1 required for inflammatory conjunctival cell infiltration. Current research encourages an in-depth evaluation of the exact role Th1 and Th2 cells play in ocular inflammation.
authors.affiliation: Allergan, Inc., Irvine, CA 92612, USA. stern_michael@allergan.com
authors.forename: Michael E
authors.initials: ME
authors.lastname: Stern
authors.forename: Karyn F
authors.initials: KF
authors.lastname: Siemasko
authors.forename: Jianping
authors.initials: J
authors.lastname: Gao
authors.forename: Margarita
authors.initials: M
authors.lastname: Calonge
authors.forename: Jerry Y
authors.initials: JY
authors.lastname: Niederkorn
authors.forename: Stephen C
authors.initials: SC
authors.lastname: Pflugfelder