BDNF genotype potentially modifying the association between incident stroke and depression.
OBJECTIVE
To investigate the role of the brain-derived neurotrophic factor (BDNF) gene val66met polymorphism in the association between stroke and depression.


METHODS
Five hundred community residents aged >65 years without stroke or depression at baseline were re-evaluated after 2 years. Disability (World Health Organization Disability Assessment Schedule, WHODAS II), cognitive function (Mini-Mental State Examination, MMSE), and BDNF genotype were also measured at baseline.


RESULTS
The association between incident stroke and depression was strengthened progressively with increasing numbers of met alleles, and was only significant in subjects with the met/met genotype after adjustment for disability and cognitive function.


CONCLUSIONS
The BDNF val66met polymorphism may modify the association between stroke and depression.
Kim
Jae-Min
JM
Department of Psychiatry and Depression Clinical Research Center, Chonnam National University Medical School, Kwangju, Republic of Korea.
Stewart
Robert
R
Kim
Sung-Wan
SW
Yang
Su-Jin
SJ
Shin
Il-Seon
IS
Kim
Young-Hoon
YH
Yoon
Jin-Sang
JS
D000368:Aged; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics*; D015897:Comorbidity; D003863:Depression / Q000175:diagnosis / Q000453:epidemiology* / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000235:genetics; D005838:Genotype; D006801:Humans; D015994:Incidence; D007723:Korea / Q000453:epidemiology; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D020521:Stroke / Q000175:diagnosis / Q000453:epidemiology* / Q000235:genetics*
D019208:Brain-Derived Neurotrophic Factor