Resistin gene polymorphisms and progression of glycaemia in southern Chinese: a 5-year prospective study.
OBJECTIVE
Human resistin gene (RETN) polymorphisms have been found to be associated with type 2 diabetes (T2DM), insulin resistance and/or obesity. We evaluated, in a 5-year prospective study, whether RETN polymorphisms could predict the progression of glycaemia in southern Chinese.


METHODS
We conducted a systematic search for variants in RETN in 70 southern Chinese subjects. This was followed by the genotyping in 624 unrelated nondiabetic subjects of two polymorphisms, -420C-->G and +62G-->A, previously reported in cross-sectional studies to be associated with T2DM in Asians, to examine their relationship with the progression of glycaemia in this cohort.


RESULTS
We identified 15 polymorphisms, including 2 novel but rare polymorphisms (-319G-->A and +63G-->C). Compared to subjects with the CC genotype, -420GG subjects had higher 2-h glucose (7.7 +/- 1.8 vs. 7.2 +/- 2.0 mmol/l, P = 0.011) and insulin (101.6 +/- 69.5 vs. 79.8 +/- 59.5 mU/l, P = 0.021) during an oral glucose tolerance test. Carriers of the +62A allele had higher body mass indices (25.3 +/- 4.0 vs. 24.5 +/- 3.6 kg/m(2) in GG, P = 0.02). The presence of the allele -420G (OR 2.15, 95% CI 1.28-3.60, P = 0.004) or +62A (OR1.86, 95% CI 1.08-3.21, P = 0.025) predicted the progression of glycaemia at Year 5, after adjustment for sex, age or body mass index. The haplotype G-A also conferred a higher risk of progression in glycaemia (P = 0.002).


CONCLUSIONS
Our study would support the role of the resistin gene in obesity, insulin resistance and progression of glycaemia in southern Chinese.
Xu
Jian Yu
JY
Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, China.
Sham
Pak C
PC
Xu
Aimin
A
Tso
Annette W K
AW
Wat
Nelson M S
NM
Cheng
King Yip
KY
Fong
Carol H Y
CH
Janus
Edward D
ED
Lam
Karen S L
KS
D000328:Adult; D002681:China; D018450:Disease Progression; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D006943:Hyperglycemia / Q000235:genetics*; D007333:Insulin Resistance / Q000235:genetics; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D011446:Prospective Studies; D052243:Resistin / Q000235:genetics*
D052243:Resistin