Primary nodal marginal zone B-cell lymphoma: clinical features and prognostic assessment of a rare disease.
This study defined the clinical features and assessed the prognosis of 47 patients (17 males, 30 females, median age 63 years) with primary nodal marginal zone B-cell lymphoma. Forty-five per cent had stage IV disease. Hepatitis C virus serology was positive in 24%. According to the Follicular Lymphoma International Prognostic Index (FLIPI), 33% were classified as low-risk, 34% as intermediate-risk, and 33% as high-risk. The 5-year overall survival (OS) was 69%. In univariate analysis worse OS was associated with: FLIPI (P = 0.02), age > 60 years (P = 0.05) and raised lactate dehydrogenase (P = 0.05). In multivariate analysis, only FLIPI predicted a worse OS (P = 0.02).
Arcaini
Luca
L
Division of Haematology, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy. luca.arcaini@unipv.it
Paulli
Marco
M
Burcheri
Sara
S
Rossi
Andrea
A
Spina
Michele
M
Passamonti
Francesco
F
Lucioni
Marco
M
Motta
Teresio
T
Canzonieri
Vincenzo
V
Montanari
Mauro
M
Bonoldi
Emanuela
E
Gallamini
Andrea
A
Uziel
Lilj
L
Crugnola
Monica
M
Ramponi
Antonio
A
Montanari
Francesca
F
Pascutto
Cristiana
C
Morra
Enrica
E
Lazzarino
Mario
M
D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage; D003520:Cyclophosphamide / Q000008:administration & dosage; D018572:Disease-Free Survival; D004317:Doxorubicin / Q000008:administration & dosage; D005260:Female; D016174:Hepacivirus; D006526:Hepatitis C / Q000150:complications; D006801:Humans; D016130:Immunophenotyping; D016393:Lymphoma, B-Cell / Q000188:drug therapy / Q000473:pathology* / Q000821:virology; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011241:Prednisone / Q000008:administration & dosage; D011379:Prognosis; D035583:Rare Diseases / Q000188:drug therapy / Q000473:pathology* / Q000821:virology; D016019:Survival Analysis; D014750:Vincristine / Q000008:administration & dosage
D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011241:Prednisone