title: [The fungus Penicillium variabile sopp 1912 isolated from permafrost deposits as a producer of rugulovasines].
abstract: It has been established that relict fungi Penicillium variabile Sopp can synthesize clavine alkaloids, rugulovasines A and B, which are revealed in this species for the first time. Submerged cultivation of the strain-producer revealed several microcycles of conidia formation. The synthesis of alkaloids was also of a cyclic character. The synchronism beween the cycles of rugulovasine biosynthesis and conidia formation was revealed. Zinc ions stimulated fungal growth but had a negative effect on the biosynthesis of rugulovasines.
authors.forename: V P
authors.initials: VP
authors.lastname: Zhelifonova
authors.forename: T V
authors.initials: TV
authors.lastname: Antipova
authors.forename: S M
authors.initials: SM
authors.lastname: Ozerskaia
authors.forename: N E
authors.initials: NE
authors.lastname: Ivanushkina
authors.forename: A G
authors.initials: AG
authors.lastname: Kozlovskiĭ
mesh_terms: D001110:Arctic Regions; D019015:Geologic Sediments / Q000382:microbiology*; D007053:Ice; D007211:Indoles / Q000378:metabolism*; D009183:Mycotoxins / Q000378:metabolism*; D010407:Penicillium / Q000302:isolation & purification / Q000378:metabolism* / Q000502:physiology; D013172:Spores, Fungal / Q000254:growth & development; D015032:Zinc / Q000502:physiology
chemical_list: D007053:Ice; D007211:Indoles; D009183:Mycotoxins; C027115:rugulovasine B; C027114:rugulovasine A; D015032:Zinc