Enantioselective intramolecular aldol addition/dehydration reaction of a macrocyclic diketone: synthesis of the musk odorants (R)-muscone and (R,Z)-5-muscenone.
Knopff
Oliver
O
Firmenich SA, Corporate R&D Division, B.P. 239, 1211, Genève 8, Switzerland. oliver.knopff@firmenich.com
Kuhne
Jérôme
J
Fehr
Charles
C
D000447:Aldehydes / Q000737:chemistry*; D003516:Cycloparaffins / Q000138:chemical synthesis* / Q000737:chemistry; D007659:Ketones / Q000138:chemical synthesis / Q000737:chemistry*; D007700:Kinetics; D047028:Macrocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D008958:Models, Molecular; D015394:Molecular Structure; D013237:Stereoisomerism; D014867:Water / Q000737:chemistry*
C518850:(R,Z)-5-muscenone; D000447:Aldehydes; D003516:Cycloparaffins; D007659:Ketones; D047028:Macrocyclic Compounds; D014867:Water; C116609:3-hydroxybutanal; C031021:muscone