title: [Case of submucosal esophageal carcinoma with multiple liver metastasis showing high serum levels of CEA and CA19-9].
abstract: A 57-year-old man was admitted because of abdominal fullness. An abdominal ultrasonographic study disclosed multiple space-occupying lesions (SOL) in the liver. On blood examinationC the serum levels of CEA and CA19-9 were significantly high while those of AFP and SCC were within normal ranges. Endoscopically biopsied specimens of the lower esophagus histologically revealed poorly differentiated squamous cell carcinoma. Pathohistologically similar findings were obtained from the needle biopsied specimen of the SOL in the liver. Thus the patient was diagnosed as having squamous cell carcinoma of the esophagus with liver metastasis. On the 41st hospital day the patient died and an autopsy was performed. Although multiple metastases were recognized, cancer cells were limited within the submucosa of the esophagus. Immunostaining of CEA and CA19-9 was positive on the carcinoma cells both in the esophagus and the liver. Thus a relation between the biological malignancy of esophageal cancer and serum levels of CEA and CA19-9 was suggested.
authors.affiliation: Department of Internal Medicine, Tokyo Metropolitan Health and Medical Treatment Corporation Ebara Hospital, Japan.
authors.forename: Toshikazu
authors.initials: T
authors.lastname: Kurihara
authors.forename: Shigeaki
authors.initials: S
authors.lastname: Ishii
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Ozawa
authors.forename: Katsurou
authors.initials: K
authors.lastname: Tsubo
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Fukushima
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Funatomi
authors.forename: Toshitaka
authors.initials: T
authors.lastname: Kagaya
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Ohike
authors.forename: Manabu
authors.initials: M
authors.lastname: Takahashi
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood*; D018395:CA-19-9 Antigen / Q000097:blood*; D002272:Carcinoembryonic Antigen / Q000097:blood*; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000473:pathology / Q000556:secondary*; D004938:Esophageal Neoplasms / Q000175:diagnosis / Q000473:pathology*; D017809:Fatal Outcome; D006801:Humans; D008113:Liver Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000556:secondary*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging
chemical_list: D014408:Biomarkers, Tumor; D018395:CA-19-9 Antigen; D002272:Carcinoembryonic Antigen