title: A new approach for low-cost noninvasive detection of asymptomatic heart disease at rest.
abstract: It would be useful to have an inexpensive, noninvasive point-of-care test for early detection of asymptomatic heart disease. This study used impedance cardiography (ICG) in a new way to assess heart function that did not use stroke volume or cardiac output. There is a model of the ICG dZ/dt waveform that may be used as a template to represent normal heart function. The hypothesis was that a dZ/dt waveform which deviates from that template should indicate heart dysfunction and therefore heart disease. The objective was to assess the accuracy of this new ICG approach, using echocardiography as the standard. Thirty-four outpatients undergoing echocardiographic testing were tested by ICG while sitting upright and supine. All patients had no symptoms or history of a structural or functional heart disorder. Echocardiographic testing showed 17 patients with abnormalities and 17 as normal. ICG testing yielded 16 true positives for heart dysfunction with 1 false negative (sensitivity = 94%) and 17 true negatives with no false positives (specificity = 100%). Considering that the cost, technical skill, and time required for this ICG test are comparable to those of an electrocardiograph, this new approach has potential as a point-of-care screening test for asymptomatic heart disease.
authors.affiliation: Dermed Diagnostics Inc, Wheaton, IL 60187, USA. ademarzo.dermed@att.net
authors.forename: Arthur P
authors.initials: AP
authors.lastname: DeMarzo
authors.forename: James E
authors.initials: JE
authors.lastname: Calvin
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002307:Cardiography, Impedance / Q000191:economics / Q000379:methods*; D005260:Female; D006331:Heart Diseases / Q000175:diagnosis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D019095:Point-of-Care Systems; D011187:Posture; D012146:Rest