Neuropharmacological activity of Eupatorium buniifolium aqueous extract in mice.
The aim of this study was to evaluate the neuropharmacological profile of the Eupatorium buniifolium aqueous extract (EB) in mice. EB at doses up to 1.5 g/kg p.o. of the lyophilized material produced a dose dependent sleep induction and potentiation of sub-hypnotic and hypnotic doses of pentobarbital, respectively. However, EB neither modified the spontaneous motor activity nor produced a myorelaxant effect. Moreover, EB 1.5 g/kg in a nose-poke habituation task, produced a disruption of the normal patterns of habituation, and in a step-down inhibitory avoidance task, induced an amnesic effect similar to diazepam. These results suggest that the activity of EB may be a CNS-depressant.
Miño
Jorge
J
Cátedra de Farmacología, Departamento de Farmacología, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Junín 956 (1113AAD), Buenos Aires, Argentina.
Muschietti
Liliana
L
Ferraro
Graciela
G
Martino
Virginia
V
Acevedo
Cristina
C
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D036602:Eupatorium; D005260:Female; D006185:Habituation, Psychophysiologic / Q000187:drug effects; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D009420:Nervous System / Q000187:drug effects*; D010936:Plant Extracts / Q000494:pharmacology*; D012890:Sleep / Q000187:drug effects
D010936:Plant Extracts