[Atypical antipsychotic-induced weight gain].
Introduction of a new group of antipsychotic drugs, called atypical because of the proprieties differing them from classical neuroleptics, gave hope for the beginning of a new era in treatment of psychoses, including schizophrenia. Different mechanisms of action not only resulted in a broader spectrum of action and high efficacy but also in a relative lack of extrapiramidal symptoms. However, atypical neuroleptics are not totally free from adverse effects. Symptoms such as sedation, metabolic changes and weight gain, often very quick and severe - present also in the case of classical drugs, but put to the background by extrapiramidal symptoms--have become prominent. Weight gain is important both from the clinical and subjective point of view--as associated with serious somatic consequences and as a source of enormous mental distress. These problems are addressed in this review, with the focus on weight gain associated with the use of specific atypical neuroleptics.
Godlewska
Beata R
BR
Klinika Chorób Psychicznych i Zaburzeń Nerwicowych AM w Gdańisku.
Olajossy-Hilkesberger
Luiza
L
Marmurowska-Michałowska
Halina
H
Olajossy
Marcin
M
Landowski
Jerzy
J
D014150:Antipsychotic Agents / Q000009:adverse effects; D002986:Clinical Trials as Topic; D004703:Endocrine System / Q000187:drug effects; D006801:Humans; D001523:Mental Disorders / Q000188:drug therapy*; D009765:Obesity / Q000139:chemically induced*; D011618:Psychotic Disorders / Q000188:drug therapy; D012044:Regression Analysis; D012107:Research Design; D015430:Weight Gain / Q000187:drug effects*
D014150:Antipsychotic Agents