title: Effect of simultaneous intracoronary guidewires on the predictive accuracy of functional parameters of coronary lesion severity.
abstract: The aim of this study was to assess the influence of a second guidewire on the diagnostic accuracy of functional parameters of coronary lesion severity. Sixty-five patients with intermediate coronary lesions underwent myocardial perfusion scintigraphy. Fractional flow reserve (FFR), coronary flow velocity reserve (CFVR), and hyperemic stenosis resistance (HSR) index (HSR = stenosis pressure gradient / velocity) were determined in 77 lesions. Distal pressure and velocity were acquired simultaneously (dual wire) and sequentially (single wire) with two sensor-equipped guidewires. Overall, functional parameters deteriorated from single- to dual-wire assessment. In patients without ischemia, the good diagnostic performance of FFR, CFVR, and HSR deteriorated significantly (P < 0.001) when assessed by dual wires, with an increase in the number of false-positive results. This trend was more pronounced for HSR, since the presence of a second wire reduced maximal velocity and increased the pressure gradient. The presence of two guidewires, especially across a myocardial perfusion scintigraphy-induced nonsignificant lesion, is associated with overestimation of the hemodynamically assessed lesion severity and, therefore, is likely to have a major impact on clinical decision making. This underscores the advantage of a dual-sensor-equipped guidewire for the evaluation of stenosis severity by combined pressure and velocity measurements.
authors.affiliation: Department of Nuclear Medicine, Academic Medical Center, Meibergdreef 9, 1100 DE Amsterdam, The Netherlands. h.j.verberne@amc.uva.nl
authors.forename: Hein J
authors.initials: HJ
authors.lastname: Verberne
authors.forename: Martijn
authors.initials: M
authors.lastname: Meuwissen
authors.forename: Steven A J
authors.initials: SA
authors.lastname: Chamuleau
authors.forename: Bart-Jan
authors.initials: BJ
authors.lastname: Verhoeff
authors.forename: Berthe L F
authors.initials: BL
authors.lastname: van Eck-Smit
authors.forename: Jos A E
authors.initials: JA
authors.lastname: Spaan
authors.forename: Jan J
authors.initials: JJ
authors.lastname: Piek
authors.forename: Maria
authors.initials: M
authors.lastname: Siebes
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D006328:Cardiac Catheterization / Q000379:methods*; D003326:Coronary Circulation; D023921:Coronary Stenosis / Q000145:classification / Q000175:diagnosis* / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D014655:Vascular Resistance