title: Pentoxifylline therapy: a new adjunct in the treatment of oral submucous fibrosis.
abstract: OBJECTIVE
  This study was designed to determine the effect of pentoxifylline (Trental) on the clinical and pathologic course of oral submucous fibrosis. This drug is a methylxanthine derivative that has vasodilating properties and was envisaged to increase mucosal vascularity.
  
  
  METHODS
  This investigation was conducted as a randomized clinical trial incorporating a control group (Standard drug group SDG, multivitamin, and local heat therapy) in comparison to pentoxifylline test cases (Experimental drug group EDG, 400mg 3 times daily, as coated, sustained release tablets). The stipulated treatment period was 7 months and a total of 29 cases of advanced fibrosis (14 test subjects and 15 age and sex matched diseased controls) were included in this study and 100% compliance was reported at the end ofthe test period.
  
  
  RESULTS
  Mild gastric irritation that could be managed by diet protocols was the only untoward symptom reported during this trial. Review of the patients and controls was done at an interval of 30 days and subjective and objective measurements were recorded. The follow up data at each visit with respect to each other and to base-line values was calibrated using a nonparametric test of Mann-Whitney (Kruskal-Wallis test). Significant comparisons with regard to improvement were recorded as objective criteria of mouth opening (t=11.285, p= 0.000), tongue protrusion (t= 3.898, p = 0.002), and relief from perioral fibrotic bands (p = 0.0001554). Subjective symptoms of intolerance to spices (p = 0.0063218), burning sensation of mouth (p = 0.0005797), tinnitus (p=0.000042), difficulty in swallowing (p=0.0000714). and difficulty in speech (p=0.0000020) were also recorded significant improvement at the end of the trial period.
  
  
  CONCLUSIONS
  This pilot investigation points to the effectiveness of pentoxifylline as an adjunct therapy in the routine management of oral submucous fibrosis.
authors.affiliation: Department of Oral Pathology & Microbiology, Govt Dental College, Trivandrum, Kerala. rrajendran_r@yahoo.co.in
authors.forename: R
authors.initials: R
authors.lastname: Rajendran
authors.forename: Vidya
authors.initials: V
authors.lastname: Rani
authors.forename: Saleem
authors.initials: S
authors.lastname: Shaikh
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D003680:Deglutition Disorders / Q000503:physiopathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008334:Mandible / Q000503:physiopathology; D009061:Mouth Mucosa / Q000187:drug effects; D009068:Movement; D009914:Oral Submucous Fibrosis / Q000188:drug therapy* / Q000503:physiopathology; D010431:Pentoxifylline / Q000008:administration & dosage / Q000627:therapeutic use*; D010865:Pilot Projects; D011446:Prospective Studies; D012472:Salivation / Q000187:drug effects; D014012:Tinnitus / Q000503:physiopathology; D014059:Tongue / Q000187:drug effects; D016896:Treatment Outcome; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D014832:Voice Disorders / Q000503:physiopathology
chemical_list: D014665:Vasodilator Agents; D010431:Pentoxifylline