Bipolar phospholipid sensing by TRPC5 calcium channel.
TRPC5 [TRP (transient receptor potential) canonical (or classical) 5] is a widely expressed mammalian homologue of Drosophila TRP, forming a calcium- and sodium-permeable channel in the plasma membrane either as a homomultimer or heteromultimer with other proteins (e.g. TRPC1). Although several factors are known to stimulate the channel, understanding of its endogenous activators and functions is limited. This paper provides a brief and focused review of our latest findings that show that TRPC5 is a sensor of important signalling phospholipids, including lysophosphatidylcholine and sphingosine 1-phosphate, acting extracellularly or intracellularly. Underlying mechanisms of action and biological relevance are discussed.
Beech
D J
DJ
Institute of Membrane and Systems Biology, Garstang Building, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK. d.j.beech@leeds.ac.uk
D000818:Animals; D002118:Calcium / Q000737:chemistry / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism; D006801:Humans; D008051:Lipid Bilayers / Q000737:chemistry; D008055:Lipids / Q000737:chemistry; D008244:Lysophosphatidylcholines / Q000737:chemistry; D008246:Lysophospholipids / Q000737:chemistry; D008954:Models, Biological; D010743:Phospholipids / Q000737:chemistry*; D015398:Signal Transduction; D012964:Sodium / Q000737:chemistry; D013110:Sphingosine / Q000031:analogs & derivatives / Q000737:chemistry; D050052:TRPC Cation Channels / Q000737:chemistry* / Q000502:physiology*
D008051:Lipid Bilayers; D008055:Lipids; D008244:Lysophosphatidylcholines; D008246:Lysophospholipids; D010743:Phospholipids; D050052:TRPC Cation Channels; C491780:TRPC5 protein, human; C060506:sphingosine 1-phosphate; D012964:Sodium; D013110:Sphingosine; D002118:Calcium