In vitro inhibition of Streptococcus mutans biofilm formation on hydroxyapatite by subinhibitory concentrations of anthraquinones.
We report that certain anthraquinones (AQs) reduce Streptococcus mutans biofilm formation on hydroxyapatite at concentrations below the MIC. Although AQs are known to generate reactive oxygen species, the latter do not underlie the observed effect. Our results suggest that AQs inhibit S. mutans biofilm formation by causing membrane perturbation.
Coenye
Tom
T
Laboratorium voor Farmaceutische Microbiologie, Universiteit Gent, Harelbekestraat 72, B-9000 Gent, Belgium. Tom.Coenye@UGent.be
Honraet
Kris
K
Rigole
Petra
P
Nadal Jimenez
Pol
P
Nelis
Hans J
HJ
D000880:Anthraquinones / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D018441:Biofilms / Q000187:drug effects* / Q000254:growth & development; D017886:Durapatite / Q000378:metabolism; D008826:Microbial Sensitivity Tests; D013295:Streptococcus mutans / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism
D000880:Anthraquinones; D000900:Anti-Bacterial Agents; D017886:Durapatite