[Immunostimulant properties of polyoxidon on the model of acute poisoning with anticholinesterase chemicals in rats].
Experiments on noninbred rats showed that, upon acute poisoning with toxic chemicals (sarin, VX agent; 1.0 LD50) and the treatment with atropine (10 mg/kg), the administration of polyoxidon in a daily dose of 100 mg/kg over 4 days partly reduces the degree of immune system suppression and the level of lipid peroxidation induced by toxic chemicals.
Zabrodskiĭ
P F
PF
Mandych
V G
VG
Germanchuk
V G
VG
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D002800:Cholinesterase Inhibitors / Q000506:poisoning*; D005260:Female; D007108:Immune Tolerance / Q000187:drug effects*; D008297:Male; D009930:Organic Chemicals / Q000494:pharmacology; D009946:Organothiophosphorus Compounds / Q000037:antagonists & inhibitors* / Q000506:poisoning; D051381:Rats; D012524:Sarin / Q000037:antagonists & inhibitors* / Q000506:poisoning
D000276:Adjuvants, Immunologic; D002800:Cholinesterase Inhibitors; D009930:Organic Chemicals; D009946:Organothiophosphorus Compounds; D012524:Sarin; C089921:polyoxydonium; C009680:VX-agent