title: Diffusion tensor imaging segmentation of white matter structures using a Reproducible Objective Quantification Scheme (ROQS).
abstract: Reproducible Objective Quantification Scheme (ROQS) is a novel method for regional white matter measurements of diffusion tensor imaging (DTI) parameters that overcomes the limitations of previous approaches for analyzing large cohorts of subjects reliably. ROQS is a semi-automated technique that exploits the fiber orientation information from the diffusion tensor in conjunction with a binary masking and chain-linking algorithm to segment anatomically distinct white matter tracts for subsequent quantitative analysis of DTI parameters such as fractional anisotropy and apparent diffusion coefficient. When applied to 3-T whole-brain DTI of normal adult volunteers, ROQS is shown to segment the corpus callosum much faster than manual region of interest (ROI) delineation, and with better reproducibility and accuracy.
authors.affiliation: Sackler Institute for Developmental Psychobiology, Weill Cornell Medical College, 1300 York Avenue, Box 140, New York, NY 10021, USA.
authors.forename: Sumit N
authors.initials: SN
authors.lastname: Niogi
authors.forename: Pratik
authors.initials: P
authors.lastname: Mukherjee
authors.forename: Bruce D
authors.initials: BD
authors.lastname: McCandliss
mesh_terms: D000328:Adult; D000465:Algorithms; D016880:Anisotropy; D001921:Brain / Q000033:anatomy & histology*; D003337:Corpus Callosum / Q000033:anatomy & histology / Q000502:physiology; D016208:Databases, Factual; D038524:Diffusion Magnetic Resonance Imaging / Q000706:statistics & numerical data*; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000706:statistics & numerical data*; D015588:Observer Variation; D012016:Reference Values; D015203:Reproducibility of Results