Primary lymphoma of the central nervous system: a clinical-pathological and immunohistochemical study of ten autopsy cases.
BACKGROUND
Primary central nervous system lymphomas (PCNSL) are a rare subgroup of lymphomas generally associated with HIV and EBV.


OBJECTIVE
To study ten autopsy cases of PCNSL, to describe the neuropathological findings, to characterize the phenotype of the neoplastic cells, to detect EBV in the lesion and to compare the findings with the clinical and laboratory data of the patients.


METHODS
The clinical, histological and immunohistochemical data of ten cases of PCNSL, eight cases from patients with AIDS, identified among 265 autopsies of these patients were analyzed.


RESULTS
Seven patients were males and the mean age was 40.9 years. The most frequent symptomatology was focal neurologic deficit (70%). Six patients presented with only one lesion. Histologically, densely cellular and polymorphous neoplasms with angiocentrism were observed, in 90% of cases. An association with other diseases was observed in four cases. Most patients had diffuse large B cell non-Hodgkins lymphoma. EBV was detected by immunohistochemistry in only one case. The lack of detection of the virus might have been due to the long time of fixation of the brain which might have inactivate epitopes therefore compromising the testing.


CONCLUSIONS
In the present series, PCNSL presented with focal symptoms, with unifocal or multifocal lesions, with a predominant B-cell CD20 positive phenotype, rarely associated with EBV.
Costa
Henrique
H
Department of Pathology, State University of Health Sciences of Alagoas, Maceió, AL, Brazil. lapac@uol.com.br
Franco
Marcello
M
Hahn
Myriam Dumas
MD
D000328:Adult; D001344:Autopsy; D016543:Central Nervous System Neoplasms / Q000473:pathology* / Q000821:virology; D020031:Epstein-Barr Virus Infections / Q000473:pathology / Q000821:virology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008223:Lymphoma / Q000473:pathology* / Q000821:virology; D016483:Lymphoma, AIDS-Related / Q000473:pathology / Q000821:virology; D008297:Male; D008875:Middle Aged