title: Increased circulating platelet-derived microparticles are associated with stent-induced vascular inflammation.
abstract: Inflammation as well as platelet activation at the site of local vessel-wall injury plays an essential role in the mechanism of restenosis after Percutaneous coronary intervention (PCI). Platelet-derived microparticles (PDMPs) released from activated platelets are thought to play a role in the inflammatory process, possibly interacting with leukocyte integrin Mac-1. We serially measured circulating PDMPs, high-sensitive C-reactive protein (hs-CRP) and activated Mac-1 on the surface of neutrophils in 61 patients undergoing coronary stenting. PDMPs, hs-CRP and Mac-1 increased after coronary stenting in a time-dependent manner with the maximum response at 48 h in coronary sinus blood (PDMPs: 10.3+/-8.9-32.8+/-13.8 U/ml; P<0.001, hs-CRP: 0.27+/-0.23-1.46+/-0.99 mg/dl; P<0.001, activated Mac-1, 134+/-19% relative increase, P<0.001). PDMPs were correlated with hs-CRP (R=0.58, P<0.001) and the relative increase in Mac-1 (R=0.69, P<0.001) 48 h after coronary stenting. Multiple regression analysis showed that each of PDMPs (R=0.40, P<0.05), hs-CRP (R=0.33, P<0.05) and Mac-1 (R=0.48, P<0.01) was an independent predictor of the late lumen loss. Coronary stenting enhanced circulating PDMPs in association with an inflammatory response in the injured vessel wall. PDMPs may be a useful marker for evaluation of stent-induced inflammatory status and a powerful predictor of restenosis equivalent to activated Mac-1.
authors.affiliation: Department of Cardiovascular and Renal Medicine, Saga University Faculty of Medicine, 5-1-1 Nabeshima, Saga 849-8501, Japan. Electronic address: inouete@med.saga-u.ac.jp.
authors.forename: Teruo
authors.initials: T
authors.lastname: Inoue
authors.affiliation: Department of Cardiovascular and Renal Medicine, Saga University Faculty of Medicine, 5-1-1 Nabeshima, Saga 849-8501, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Komoda
authors.affiliation: Department of Cardiovascular and Renal Medicine, Saga University Faculty of Medicine, 5-1-1 Nabeshima, Saga 849-8501, Japan.
authors.forename: Norihiko
authors.initials: N
authors.lastname: Kotooka
authors.affiliation: Department of Cardiovascular and Renal Medicine, Saga University Faculty of Medicine, 5-1-1 Nabeshima, Saga 849-8501, Japan.
authors.forename: Toshifumi
authors.initials: T
authors.lastname: Morooka
authors.affiliation: Department of Cardiovascular and Renal Medicine, Saga University Faculty of Medicine, 5-1-1 Nabeshima, Saga 849-8501, Japan.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Fujimatsu
authors.affiliation: Department of Cardiovascular and Renal Medicine, Saga University Faculty of Medicine, 5-1-1 Nabeshima, Saga 849-8501, Japan.
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Hikichi
authors.affiliation: Department of Cardiovascular and Renal Medicine, Saga University Faculty of Medicine, 5-1-1 Nabeshima, Saga 849-8501, Japan.
authors.forename: Ryoichi
authors.initials: R
authors.lastname: Soma
authors.affiliation: Department of Cardiology, Koshigaya Hospital, Dokkyo Medical University, Koshigaya, Japan.
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Uchida
authors.affiliation: Department of Cardiovascular and Renal Medicine, Saga University Faculty of Medicine, 5-1-1 Nabeshima, Saga 849-8501, Japan.
authors.forename: Koichi
authors.initials: K
authors.lastname: Node
mesh_terms: D000368:Aged; D015906:Angioplasty, Balloon, Coronary / Q000009:adverse effects*; D015415:Biomarkers / Q000097:blood; D001792:Blood Platelets / Q000473:pathology*; D002097:C-Reactive Protein / Q000276:immunology; D003324:Coronary Artery Disease / Q000097:blood / Q000276:immunology* / Q000601:surgery; D023903:Coronary Restenosis / Q000097:blood; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood*; D016177:Macrophage-1 Antigen / Q000097:blood; D008297:Male; D008875:Middle Aged; D010316:Particle Size; D015607:Stents / Q000009:adverse effects*
chemical_list: D015415:Biomarkers; D016177:Macrophage-1 Antigen; D002097:C-Reactive Protein