The role of sICAM-1 detection in the diagnosis of acute rejection following liver transplantation.
In order to evaluate the applied value of soluble intracellular adhesion molecule-1 (sICAM-1) in acute rejection (AR) following liver transplantation, the expression of sICAM-1 protein was sequentially detected by using ELISA in serum and bile of 43 patients receiving liver transplantation. In AR group, the expression levels of sICAM-1 protein were increased 3 days before and immediately on the establishment of AR diagnosis, and there was significant difference in the expression of bile between AR group and control group (P<0.01). After reversion of AR with hormone intensive therapy, there was significant difference in the sICAM-1 protein expression of serum and bile between AR group and control group. It was concluded that the sequential detection of sICAM-1 protein level in serum and bile was a reliable and noninvasive method for the early diagnosis of AR after liver transplantation and was valuable to observe the curative effects of anti-AR therapy.
Yu
Yahong
Y
Department of General Surgery, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Chen
Zhong
Z
Ye
Qifa
Q
D000328:Adult; D001646:Bile / Q000737:chemistry; D005260:Female; D006084:Graft Rejection / Q000175:diagnosis*; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000032:analysis / Q000097:blood*; D016031:Liver Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D055815:Young Adult
D018799:Intercellular Adhesion Molecule-1