Future investigations in stem cell activation with granulocyte-colony-stimulating factor after myocardial infarction.
Experimental data indicate that stem cell mobilization with granulocyte colony-stimulating factor (G-CSF) might have potential as a novel therapeutic strategy for acute myocardial infarction. The prospective beneficial effects of G-CSF can be attributed mainly to a direct action on injured myocardium rather than on differentiation of mobilized bone marrow stem cells into cardiac myocytes. This article reviews the evidence for the potential cardioprotective effects of G-CSF and discusses future investigations regarding pharmacologic stem cell activation and mobilization with G-CSF in the setting of acute myocardial infarction.
Ince
Hüseyin
H
Division of Cardiology, University Hospital Rostock, Rostock School of Medicine, Ernst-Heydemann-Strasse 6, 18057 Rostock, Germany. hueseyin.ince@med.uni-rostock.de
Nienaber
Christoph A
CA
D000818:Animals; D002465:Cell Movement / Q000187:drug effects; D004195:Disease Models, Animal; D016179:Granulocyte Colony-Stimulating Factor / Q000494:pharmacology*; D006321:Heart / Q000502:physiology*; D051379:Mice; D009203:Myocardial Infarction / Q000628:therapy*; D011817:Rabbits; D012038:Regeneration / Q000187:drug effects*; D013234:Stem Cells / Q000187:drug effects* / Q000502:physiology
D016179:Granulocyte Colony-Stimulating Factor