Histone H1 regulates chromatin condensation in Leishmania parasites.
We investigated the functional role of the Leishmania histone H1 and demonstrate for the first time that addition of histone H1 has a strong effect on microccocal digestion, chromatin condensation of parasite nuclei and that its overexpression can modulate parasite infectivity in vivo.
Masina
Slavica
S
Department of Biochemistry, University of Lausanne, Chemin des Boveresses 155, CH-1066, Epalinges, Switzerland. slavica.masina@unil.ch
Zangger
Haroun
H
Rivier
Denis
D
Fasel
Nicolas
N
D000818:Animals; D002460:Cell Line; D002843:Chromatin / Q000378:metabolism*; D015870:Gene Expression; D006657:Histones / Q000235:genetics / Q000502:physiology*; D018320:Leishmania major / Q000737:chemistry / Q000472:pathogenicity / Q000502:physiology*; D016773:Leishmaniasis, Cutaneous / Q000469:parasitology*; D008264:Macrophages / Q000469:parasitology; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D015398:Signal Transduction; D014162:Transfection; D014774:Virulence
D002843:Chromatin; D006657:Histones