title: New phytoecdysteroids from cultured plants of Ajuga nipponensis Makino.
abstract: An extract from aerial parts of Ajuga nipponensis Makino was examined by high performance liquid chromatography for minor ecdysteroids. Along with the compounds already reported, namely cyasterone, ajugasterone C, cyasterone 22-acetate and 22-dehydrocyasterone, the presence of three additional bands with the expected ecdysteroid-like UV absorption was observed. The structures of the isolates were unambiguously elucidated based on extensive NMR spectral studies (one and two-dimensional experiments) and pointed out three new phytoecdysteroids. One of the new compounds, 22-dehydrocyasterone 2-glucoside is just the second example of a C-2 glucosyl derivative. The other two compounds displayed hemiacetal functions in the side chain, one unprecedented, and were named ajugacetalsterone A and B.
authors.affiliation: Departament de Química Orgànica Biològica, Institut d'Investigacions Químiques i Ambientals de Barcelona Josep Pascual Vila, C.S.I.C., J. Girona 18, Barcelona, Spain. jctqob@iiqab.csic.es
authors.forename: Josep
authors.initials: J
authors.lastname: Coll
authors.forename: Yudelsy A
authors.initials: YA
authors.lastname: Tandrón
authors.forename: Xinnian
authors.initials: X
authors.lastname: Zeng
mesh_terms: D031328:Ajuga / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D026461:Ecdysteroids / Q000737:chemistry* / Q000302:isolation & purification*; D004441:Ecdysterone / Q000031:analogs & derivatives / Q000032:analysis; D009682:Magnetic Resonance Spectroscopy; D010936:Plant Extracts / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*
chemical_list: D026461:Ecdysteroids; D010936:Plant Extracts; D004441:Ecdysterone