The role of metformin in the treatment of polycystic ovary syndrome (PCOS).
Hyperinsulinemia is believed to be a key link in the enigmatic generation of the symptoms of polycystic ovarian syndrome (PCOS), which include anovulatory infertility and the skin stigmata induced by hyperandrogenism. Regression of these symptoms may be achieved by reducing the hyperinsulinemia. Metformin, an insulin-sensitizing agent, has been proven to be of clinical usefulness both in the short-term aiding of infertility treatments and, potentially, in the prevention of the long-term sequelae for patients with PCOS.
Wang
Hsin-Shih
HS
Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital, Taipei, Taiwan 333, ROC. hswang@cgmh.org.tw
D000726:Androgen Antagonists / Q000494:pharmacology; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D008597:Menstrual Cycle / Q000187:drug effects; D008687:Metformin / Q000494:pharmacology / Q000627:therapeutic use*; D010060:Ovulation / Q000187:drug effects; D011085:Polycystic Ovary Syndrome / Q000188:drug therapy* / Q000503:physiopathology
D000726:Androgen Antagonists; D007004:Hypoglycemic Agents; D008687:Metformin