DNA vaccines: recent technological and clinical advances.
DNA vaccines generate both T cell and B cell (or antibody) mediated immunities. Methods such as prime-boost regimens and the use of adjuvants in combination with the DNA vaccine have enhanced the therapeutic effectiveness of DNA vaccines in the treatment of cancer, infectious diseases, autoimmune diseases, asthma, and other conditions.
Ulmer
Jeffrey B
JB
Novartis Vaccines, Emeryville, CA 94608, USA.
Wahren
Britta
B
Liu
Margaret A
MA
D000276:Adjuvants, Immunologic / Q000008:administration & dosage / Q000627:therapeutic use; D000818:Animals; D001327:Autoimmune Diseases / Q000628:therapy; D006801:Humans; D008954:Models, Biological; D009369:Neoplasms / Q000628:therapy; D019444:Vaccines, DNA / Q000008:administration & dosage / Q000627:therapeutic use*
D000276:Adjuvants, Immunologic; D019444:Vaccines, DNA