title: Physical properties of root cementum: Part 9. Effect of systemic fluoride intake on root resorption in rats.
abstract: BACKGROUND
  Orthodontically induced inflammatory root resorption is a common complication in orthodontic treatment. Fluoride has been reported to have a beneficial effect against root resorption in dental traumatology. The effect of fluoride on orthodontically induced inflammatory root resorption has not been investigated. This study was undertaken to investigate the effect of fluoride on the incidence of root resorption.
  
  
  METHODS
  Thirty-two female 8-week-old Wistar rats were separated into 4 groups. Two groups (6 rats per group) were controls; they did not undergo orthodontic tooth movement. The other 2 groups (10 rats per group) had orthodontic tooth movement consisting of activated 100-g closing nickel-titanium coils (NiTi 10-000-06, GAC International, Bohemia, NY) connecting the mandibular first molar to the incisors. Fluoridated water (100 ppm) was given ad libitum to 1 control and 1 experimental group. The other 2 groups received deionized water. After 2 weeks, the animals were killed, and the samples were harvested. Resorption craters were scanned with a Micro CT (SkyScan 1072, Aartselaar, Belgium). Software analysis of the scanned samples provided a volumetric measurement of the resorption craters on the mandibular molar cementum surface.
  
  
  RESULTS
  Resorption sites were found in the control samples, especially on the distal surfaces; this could be attributed to normal physiological tooth drift. Resorption sites were significantly (P <.05) increased in the groups receiving orthodontic tooth movement.
  
  
  CONCLUSIONS
  Fluoride reduces the size of resorption craters, but the effect is variable and not statistically significant (P >.05).
authors.affiliation: Discipline of Orthodontics, Faculty of Dentistry, University of Sydney, Sydney, Australia.
authors.forename: Matthew
authors.initials: M
authors.lastname: Foo
authors.forename: Alan
authors.initials: A
authors.lastname: Jones
authors.forename: M Ali
authors.initials: MA
authors.lastname: Darendeliler
mesh_terms: D000284:Administration, Oral; D000704:Analysis of Variance; D000818:Animals; D003739:Dental Cementum / Q000000981:diagnostic imaging / Q000378:metabolism*; D005260:Female; D011857:Radiographic Image Interpretation, Computer-Assisted; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D012391:Root Resorption / Q000209:etiology / Q000517:prevention & control*; D012969:Sodium Fluoride / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D014057:Tomography, X-Ray Computed / Q000379:methods; D014087:Tooth Movement Techniques / Q000009:adverse effects*
chemical_list: D012969:Sodium Fluoride