title: Fluoro-pegylated (FPEG) imaging agents targeting Abeta aggregates.
abstract: A novel approach of producing positron emission tomography (PET) imaging agents through the formation of bioconjugates based on a pegylation-fluorination strategy resulting in fluoro-pegylated (FPEG) molecules is reported. This approach offers a simple and easy method by which to incorporate 18F in the target molecule without an appreciable increase in the lipophilicity. After 18F labeling, this convenient approach leads to PET imaging probes binding to Abeta aggregates in the brain (an important factor associated with Alzheimer's disease) using the known core structures, such as [2-(4-dimethylaminophenyl)-vinyl]-benzoxazol (3') or 2-phenylbenzothiazole (4). This approach appears to be effective in some core structures, but it cannot be uniformly applied to all structures.
authors.affiliation: Department of Radiology, University of Pennsylvania, 3700 Market Street, Room 305, Philadelphia, Pennsylvania 19104, USA. kunghf@sunmac.spect.upenn.edu
authors.forename: Karin A
authors.initials: KA
authors.lastname: Stephenson
authors.forename: Rajesh
authors.initials: R
authors.lastname: Chandra
authors.forename: Zhi-Ping
authors.initials: ZP
authors.lastname: Zhuang
authors.forename: Catherine
authors.initials: C
authors.lastname: Hou
authors.forename: Shunichi
authors.initials: S
authors.lastname: Oya
authors.forename: Mei-Ping
authors.initials: MP
authors.lastname: Kung
authors.forename: Hank F
authors.initials: HF
authors.lastname: Kung
mesh_terms: D016229:Amyloid beta-Peptides / Q000032:analysis* / Q000378:metabolism*; D000818:Animals; D001345:Autoradiography; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism; D005461:Fluorine / Q000737:chemistry*; D051379:Mice; D015394:Molecular Structure; D011092:Polyethylene Glycols / Q000737:chemistry*; D049268:Positron-Emission Tomography; D013696:Temperature
chemical_list: D016229:Amyloid beta-Peptides; D005461:Fluorine; D011092:Polyethylene Glycols