Accelerated platelet activation in Asian Indians with diabetes and coronary artery disease--The Chennai Urban Population Study (CUPS-13).
OBJECTIVE
To assess platelet activation in south Indian type 2 diabetic subjects with and without CAD.


METHODS
Four groups of subjects were studied; Group 1 comprised of non-diabetic subjects without coronary artery disease (CAD) (n = 30). Type 2 diabetic subjects without CAD formed Group 2 (n = 30); Group 3 comprised of type 2 diabetic subjects with CAD (n = 30) and Group 4 consisted of non- diabetic subjects with CAD (n=14). CAD was diagnosed based on coronary angiographic evidence of severe double or triple vessel disease. Platelet activation was tested after an overnight fast in blood obtained from a bleeding wound at 1 minute post-incision (wound-induced activation) as well as venous blood stimulated in vitro with collagen, using whole blood flow cytometry. In subjects with CAD, aspirin was withdrawn for 7 days and nitrates for 24 hours.


RESULTS
Collagen induced GP IIb/IIIa binding was significantly higher among diabetic subjects with (28.10 +/-19.89; p<0.05) and without CAD (21.02+/-19.62; p<0.05) and non-diabetic subjects with CAD (23.89+/-15.65; p<0.05) compared to non-diabetic subjects without CAD (11.69+/-13.69). Regression analysis showed collagen induced GP IIb/IIIa binding to be significantly associated with CAD [odds ratio (OR): 1.029, p = 0.025] and diabetes (OR: 1.037, p = 0.007).


CONCLUSIONS
Increased platelet activation is seen in urban south Indians with diabetes and CAD.
Deepa
R
R
Dr. Mohan's Diabetes Specialities Centre, Madras Diabetes Research Foundation, Gopalapuram, Chennai, India.
Mohan
V
V
Premanand
C
C
Rajan
V S
VS
Karkuzhali
K
K
Velmurugan
K
K
Agarwal
S
S
Gross
M D
MD
Markovitz
J
J
D000368:Aged; D044466:Asian People; D003324:Coronary Artery Disease / Q000097:blood* / Q000150:complications; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications; D006801:Humans; D007194:India / Q000453:epidemiology; D008875:Middle Aged; D015539:Platelet Activation; D014505:Urban Population / Q000706:statistics & numerical data*