title: A case of scirrhous gastric cancer with peritonitis carcinomatosa controlled by TS-1 + paclitaxel for 36 mo after diagnosis.
abstract: A 34-year-old female complaining of abdominal fullness was diagnosed as scirrhous gastric cancer (type 4') with peritonitis carcinomatosa in July 2002. A combined chemotherapy regimen was selected to control massive ascites; TS-1 80 mg/m(2) was given orally on d 1-14, 22-35, and paclitaxel 50 mg/m(2) was administered intravenously on d 1, 8, 22 and 29. After 2 courses of this regimen, the primary tumor was markedly reduced, and ascites completely vanished. Alopecia (grade 1, since d 30), leukocytopenia (grade 2, on d 34) and anemia (grade 2, on d 34) were the only adverse events throughout the following courses. The chemotherapy was effective for 28 mo, and then it was discontinued upon the patientos own request, and she survived for 36 mo after diagnosis.
authors.affiliation: Department of Gastroenterology and Hematology, Shiga University of Medical Science, Seta-Tsukinowa-cho, Otsu, Shiga 520-2192, Japan. yjkoizumi-1975@s9.dion.ne.jp
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Koizumi
authors.forename: Hirozumi
authors.initials: H
authors.lastname: Obata
authors.forename: Akinori
authors.initials: A
authors.lastname: Hara
authors.forename: Takashi
authors.initials: T
authors.lastname: Nishimura
authors.forename: Kenichiro
authors.initials: K
authors.lastname: Sakamoto
authors.forename: Yoshihide
authors.initials: Y
authors.lastname: Fujiyama
mesh_terms: D000005:Abdomen / Q000473:pathology; D002293:Adenocarcinoma, Scirrhous / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D000328:Adult; D000972:Antineoplastic Agents, Phytogenic / Q000009:adverse effects / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D017239:Paclitaxel / Q000009:adverse effects / Q000627:therapeutic use*; D010538:Peritonitis / Q000188:drug therapy / Q000209:etiology; D013270:Stomach / Q000473:pathology; D013274:Stomach Neoplasms / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D016896:Treatment Outcome
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D017239:Paclitaxel