Alpha-amino acid Tröger base derivatives, possible conformationally restricted scaffolds?
The first synthesis of innovative alpha-amino acid conjugates of Tröger base is reported; their potential application as conformationally restricted scaffolds is proposed and has been investigated using high level ab initio calculations.
Bew
Sean P
SP
School of Chemical Sciences & Pharmacy, University of East Anglia, Norwich, Norfolk, UK NR4 7TJ. s.bew@uea.ac.uk
Legentil
Laurent
L
Scholier
Vincent
V
Sharma
Sunil V
SV
D000596:Amino Acids / Q000138:chemical synthesis / Q000737:chemistry*; D008958:Models, Molecular; D008968:Molecular Conformation; D015394:Molecular Structure; D010455:Peptides / Q000737:chemistry
D000596:Amino Acids; D010455:Peptides