[Prophylactic hepatic arterial infusion chemotherapy after curative surgery of colorectal liver metastases--the viewpoint from patients' quality of life].
In order to establish a reasonable prophylactic hepatic arterial infusion (HAI) chemotherapy following curative resection of colorectal liver metastases, the authors performed a randomized control study comparing two regimen. A weekly 5 hour-administration of 5-FU (1500 mg) which was repeated for 8 weeks showed a comparable effect to a continuous infusion group with an identical total dosage of 5-FU. Furthermore, adverse events were observed in only several patients of each group with low grade severity, suggesting that this simple regimen with a weekly HAI is promising. We also analyzed the clinical course of patients receiving HAI using a W spiral catheter which has a shape memory alloy in its tip. The catheter was implanted angiographycally without coil fixation to the vascular wall, which allowed us to remove the catheter after cessation of the scheduled chemotherapy. In all of the patients, the catheters were easily removed without any complications. A 3D-CT angiograph revealed that the hepatic arteries were well patent in all of the patients with a 3.3 Fr type catheter. HAI chemotherapy is basically an invasive treatment. In consideration of its efficacies as well as limitations, a reasonable approach is needed from the viewpoint of patients' quality of life.
Tono
Takeshi
T
Dept. of Surgery, NTT West Osaka Hospital.
Kanoh
Toshiyuki
T
Ohnishi
Tadashi
T
Shiozaki
Ken
K
Matsushita
Masaki
M
Takemoto
Hirotoshi
H
Miyazaki
Susumu
S
Hoshino
Hiromitsu
H
Kimura
Yutaka
Y
Iwazawa
Takashi
T
Nakano
Yoshiaki
Y
Yano
Hiroshi
H
Monden
Takushi
T
D000792:Angiography; D002404:Catheterization; D015179:Colorectal Neoplasms / Q000473:pathology*; D005472:Fluorouracil / Q000008:administration & dosage* / Q000009:adverse effects; D006499:Hepatic Artery / Q000000981:diagnostic imaging; D006801:Humans; D007261:Infusions, Intra-Arterial; D008113:Liver Neoplasms / Q000517:prevention & control* / Q000556:secondary* / Q000601:surgery; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control; D011788:Quality of Life; D012189:Retrospective Studies
D005472:Fluorouracil