title: Oxidative damage to DNA and antioxidant status in aging and age-related diseases.
abstract: Aging is a complex process involving morphologic and biochemical changes in single cells and in the whole organism. One of the most popular explanations of how aging occurs at the molecular level is the oxidative stress hypothesis. Oxidative stress leads in many cases to an age-dependent increase in the cellular level of oxidatively modified macromolecules including DNA, and it is this increase which has been linked to various pathological conditions, such as aging, carcinogenesis, neurodegenerative and cardiovascular diseases. It is, however, possible that a number of short-comings associated with gaps in our knowledge may be responsible for the failure to produce definite results when applied to understanding the role of DNA damage in aging and age-related diseases.
authors.affiliation: Department of Clinical Biochemistry, Collegium Medicum in Bydgoszcz, Poland. ryszardo@cm.umk.pl
authors.forename: Ryszard
authors.initials: R
authors.lastname: Olinski
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Siomek
authors.forename: Rafal
authors.initials: R
authors.lastname: Rozalski
authors.forename: Daniel
authors.initials: D
authors.lastname: Gackowski
authors.forename: Marek
authors.initials: M
authors.lastname: Foksinski
authors.forename: Jolanta
authors.initials: J
authors.lastname: Guz
authors.forename: Tomasz
authors.initials: T
authors.lastname: Dziaman
authors.forename: Anna
authors.initials: A
authors.lastname: Szpila
authors.forename: Barbara
authors.initials: B
authors.lastname: Tudek
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000375:Aging / Q000502:physiology*; D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D015415:Biomarkers / Q000652:urine; D004249:DNA Damage; D004260:DNA Repair; D006147:Guanine / Q000031:analogs & derivatives / Q000652:urine; D006801:Humans; D008322:Mammals; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology*
chemical_list: D000975:Antioxidants; D015415:Biomarkers; C024829:8-hydroxyguanine; D006147:Guanine