[Molecular pathology and targeted therapy of clear cell renal cancer].
The golden standard of care for advanced renal cell cancer (RCC) was until now the cytokine therapy with relatively low response rates. Advances of molecular genetics in RCC revealed several molecular targets such as VHL and angiogenic genotype or EGFR in the clear cell variant. Among the novel targeted agents, multiple tyrosine kinase inhibitors were proved to be clinically effective against advanced clear cell renal cancer, changing the standard of care. It is a further question how molecular diagnostics can improve these results by the detection of these targets or gene defects in individual tumors.
Tímár
József
J
Országos Onkológiai Intézet, Budapest 1122, Hungary. jtimar@oncol.hu
Kopper
László
L
Bodrogi
István
I
D018262:Adenocarcinoma, Clear Cell / Q000188:drug therapy / Q000473:pathology; D020533:Angiogenesis Inhibitors / Q000627:therapeutic use; D002292:Carcinoma, Renal Cell / Q000737:chemistry / Q000188:drug therapy* / Q000473:pathology*; D004791:Enzyme Inhibitors / Q000627:therapeutic use; D066246:ErbB Receptors / Q000187:drug effects; D006801:Humans; D007680:Kidney Neoplasms / Q000737:chemistry / Q000188:drug therapy* / Q000473:pathology*; D011237:Predictive Value of Tests; D011505:Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors
D020533:Angiogenesis Inhibitors; D004791:Enzyme Inhibitors; D066246:ErbB Receptors; D011505:Protein-Tyrosine Kinases