title: Value of wireless capsule endoscopy in patients with indeterminate colitis (inflammatory bowel disease type unclassified).
abstract: BACKGROUND
  Wireless capsule endoscopy (WCE) can identify small bowel mucosal lesions not seen with other imaging modalities. This technique can therefore play an important diagnostic role in the evaluation of patients with inflammatory bowel disease type unclassified (IBDU). We report on a multicentric study whose objective was to evaluate the value of WCE to increase diagnostic accuracy in categorizing IBDU.
  
  
  METHODS
  Thirty patients with IBDU and negative serology were included. WCE was performed with a standard Pillcam capsule. Outcome measures were classified as suggestive of Crohn's disease (CD) when -3 ulcerations were present.
  
  
  RESULTS
  WCE displayed endoscopic features suggestive for CD in 5 patients. In 6 other patients, WCE was negative, but repeated ileocolonoscopy with biopsies performed during follow-up evaluation revealed CD in 5 and ulcerative colitis (UC) in 1 patient. UC was found in a seventh case at colectomy performed just after WCE. Eighteen patients remained with a diagnosis of IBDU 16 months on average after WCE.
  
  
  CONCLUSIONS
  WCE is a potentially clinically useful technique for categorizing a subgroup of patients with IBDU, although negative WCE does not exclude further diagnosis of CD. Patients with negative WCE who remain IBDU at follow-up evaluation may belong to an original subgroup of IBD.
authors.affiliation: Gastroenterology Department, University Hospital, Lille, France. vmaunoury@chru-lille.fr
authors.forename: Vincent
authors.initials: V
authors.lastname: Maunoury
authors.forename: Guillaume
authors.initials: G
authors.lastname: Savoye
authors.forename: Arnaud
authors.initials: A
authors.lastname: Bourreille
authors.forename: Yoram
authors.initials: Y
authors.lastname: Bouhnik
authors.forename: Marine
authors.initials: M
authors.lastname: Jarry
authors.forename: Sylvie
authors.initials: S
authors.lastname: Sacher-Huvelin
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Ben Soussan
authors.forename: Eric
authors.initials: E
authors.lastname: Lerebours
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Galmiche
authors.forename: Jean-Frederic
authors.initials: JF
authors.lastname: Colombel
mesh_terms: D000293:Adolescent; D000328:Adult; D053704:Capsule Endoscopy; D003092:Colitis / Q000175:diagnosis*; D003424:Crohn Disease / Q000175:diagnosis; D016099:Endoscopy, Gastrointestinal; D005260:Female; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000175:diagnosis*; D007421:Intestine, Small / Q000473:pathology*; D008297:Male; D008875:Middle Aged