title: The influence of estimated creatinine clearance on plasma homocysteine in hypertensive patients with normal serum creatinine.
abstract: OBJECTIVE
  To examine the relation of estimated creatinine clearance (eCrCl) and plasma total homocysteine (tHcy) in hypertensive patients with a normal serum creatinine level.
  
  
  METHODS
  A total of 137 hypertensive patients (mean age 66.6 years, 69 men) with serum creatinine level </=1.5 mg/dL gave 10-h fasting blood samples for measurement of tHcy, serum folic acid, and serum vitamin B(12).
  
  
  RESULTS
  95 patients fell into a chronic renal insufficiency (CRI) group (eCrCl< or =60 mL/min/1.73 m(2)) and 42 into a normal renal function (NRF) group (eCrCl>60 mL/min/1.73 m(2)). The CRI group was older (p<0.001), had higher tHcy (p<0.001), higher serum urea nitrogen (p<0.001), higher serum creatinine (p<0.001), lower eCrCl (p<0.001), and lower diastolic blood pressure (p=0.001). In univariate analysis, eCrCl had the strongest correlation with tHcy (r=-0.453, p<0.001). Significant correlations, ranging in decreasing order from r=-0.418, p<0.001 to r=-0.170, p=0.047, were also noted between tHcy and twelve other variables. In multivariate analysis, only eCrCl (p<0.001), usage of fibrate (p<0.001), serum level of vitamin B(12) (p=0.002), serum level of folic acid (p=0.009), and smoking (p=0.027) were independent predictors of tHcy.
  
  
  CONCLUSIONS
  eCrCl is a strong independent predictor of tHcy in hypertensive patients with normal serum creatinine.
authors.affiliation: Department of Internal Medicine, National Taiwan University Hospital Yun-Lin Branch, Yun-Lin, Taiwan.
authors.forename: Yen-Hung
authors.initials: YH
authors.lastname: Lin
authors.forename: Kuan-Yin
authors.initials: KY
authors.lastname: Pao
authors.forename: Vin-Cent
authors.initials: VC
authors.lastname: Wu
authors.forename: Yu-Li
authors.initials: YL
authors.lastname: Lin
authors.forename: Yu-Fen
authors.initials: YF
authors.lastname: Chien
authors.forename: Chi-Sheng
authors.initials: CS
authors.lastname: Hung
authors.forename: Yu-Jen
authors.initials: YJ
authors.lastname: Chen
authors.forename: Chung-Pin
authors.initials: CP
authors.lastname: Liu
authors.forename: I-Jung
authors.initials: IJ
authors.lastname: Tsai
authors.forename: Churn-Shiouh
authors.initials: CS
authors.lastname: Gau
authors.forename: Kwan-Dun
authors.initials: KD
authors.lastname: Wu
authors.forename: Juey-Jen
authors.initials: JJ
authors.lastname: Hwang
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood / Q000652:urine; D003404:Creatinine / Q000097:blood / Q000652:urine*; D005260:Female; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D006973:Hypertension / Q000150:complications*; D007674:Kidney Diseases / Q000175:diagnosis* / Q000209:etiology; D008297:Male
chemical_list: D015415:Biomarkers; D006710:Homocysteine; D003404:Creatinine