title: Red wine and green tea reduce H pylori- or VacA-induced gastritis in a mouse model.
abstract: OBJECTIVE
  To investigate whether red wine and green tea could exert anti-H pylori or anti-VacA activity in vivo in a mouse model of experimental infection.
  
  
  METHODS
  Ethanol-free red wine and green tea concentrates were administered orally as a mixture of the two beverages to H pylori infected mice, or separately to VacA-treated mice. Gastric colonization and gastric inflammation were quantified by microbiological, histopathological, and immunohistochemical analyses.
  
  
  RESULTS
  In H pylori-infected mice, the red wine and green tea mixture significantly prevented gastritis and limited the localization of bacteria and VacA to the surface of the gastric epithelium. Similarly, both beverages significantly prevented gastric epithelium damage in VacA-treated mice; green tea, but not red wine, also altered the VacA localization in the gastric epithelium.
  
  
  CONCLUSIONS
  Red wine and green tea are able to prevent H pylori-induced gastric epithelium damage, possibly involving VacA inhibition. This observation supports the possible relevance of diet on the pathological outcome of H pylori infection.
authors.affiliation: Novartis Vaccines & Diagnostics s.r.l., Research Center, Via Fiorentina 1, Siena I-53100, Italy. paolo.ruggiero@novartis.com
authors.forename: Paolo
authors.initials: P
authors.lastname: Ruggiero
authors.forename: Giacomo
authors.initials: G
authors.lastname: Rossi
authors.forename: Francesco
authors.initials: F
authors.lastname: Tombola
authors.forename: Laura
authors.initials: L
authors.lastname: Pancotto
authors.forename: Laura
authors.initials: L
authors.lastname: Lauretti
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Del Giudice
authors.forename: Mario
authors.initials: M
authors.lastname: Zoratti
mesh_terms: D000818:Animals; D001426:Bacterial Proteins / Q000378:metabolism; D028241:Camellia sinensis; D003603:Cytotoxins / Q000378:metabolism; D005756:Gastritis / Q000517:prevention & control*; D016481:Helicobacter Infections / Q000517:prevention & control*; D016480:Helicobacter pylori / Q000378:metabolism; D051379:Mice; D010936:Plant Extracts / Q000627:therapeutic use*; D013662:Tea; D027843:Vitis; D014920:Wine
chemical_list: D001426:Bacterial Proteins; D003603:Cytotoxins; D010936:Plant Extracts; D013662:Tea; C074689:VacA protein, Helicobacter pylori