title: Evidence for distinctive mechanisms of S-nitrosoglutathione metabolism by AdhC in two closely related species, Neisseria gonorrhoeae and Neisseria meningitidis.
abstract: The adhC gene from 11 strains of Neisseria gonorrhoeae was distinguished from its homologue in Neisseria meningitidis by the presence of a premature stop codon caused by a single base insertion. Mutational analysis showed that NADH S-nitrosoglutathione oxidoreductase activity was associated with adhC in Neisseria meningitidis but not in Neisseria gonorrhoeae.
authors.affiliation: Australian Bacterial Pathogenesis Program, Centre for Metals in Biology, School of Molecular and Microbial Sciences, University of Queensland, Brisbane, QLD 4072, Australia.
authors.forename: Adam J
authors.initials: AJ
authors.lastname: Potter
authors.forename: Stephen P
authors.initials: SP
authors.lastname: Kidd
authors.forename: Michael P
authors.initials: MP
authors.lastname: Jennings
authors.forename: Alastair G
authors.initials: AG
authors.lastname: McEwan
mesh_terms: D000445:Aldehyde Oxidoreductases / Q000235:genetics / Q000502:physiology*; D002384:Catalysis; D009344:Neisseria gonorrhoeae / Q000201:enzymology* / Q000235:genetics; D009345:Neisseria meningitidis / Q000201:enzymology* / Q000235:genetics; D026422:S-Nitrosoglutathione / Q000378:metabolism*
chemical_list: D026422:S-Nitrosoglutathione; C020145:formaldehyde dehydrogenase (glutathione); D000445:Aldehyde Oxidoreductases