Endocytic delivery of vancomycin mediated by a synthetic cell surface receptor: rescue of bacterially infected Mammalian cells and tissue targeting in vivo.
Boonyarattanakalin
Siwarutt
S
Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, USA.
Hu
Jianfang
J
Dykstra-Rummel
Sheryl A
SA
August
Avery
A
Peterson
Blake R
BR
D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D016503:Drug Delivery Systems / Q000379:methods*; D004705:Endocytosis / Q000187:drug effects / Q000502:physiology*; D005434:Flow Cytometry; D005453:Fluorescence; D006367:HeLa Cells; D006801:Humans; D007274:Injections, Intraperitoneal; D008089:Listeria monocytogenes / Q000187:drug effects*; D008264:Macrophages / Q000378:metabolism / Q000382:microbiology; D051379:Mice; D008807:Mice, Inbred BALB C; D008968:Molecular Conformation; D011956:Receptors, Cell Surface / Q000737:chemistry / Q000187:drug effects / Q000502:physiology*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D014018:Tissue Distribution; D014640:Vancomycin / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics
D000900:Anti-Bacterial Agents; D011956:Receptors, Cell Surface; D014640:Vancomycin