title: Intravenous drug addicts: a high risk group for infection with human immunodeficiency virus, hepatitis viruses, cytomegalo virus and bacterial infections in Alexandria Egypt.
abstract: In this work the seroprevalence of HIV, HBV, HCV and CMV were studied among two groups of population; IVDA (intravenous drug addicts) (100) and control group (40). Syphilis and other bacterial infections which may be encountered among IVDA were also investigated. It was found that all serum samples (of both groups) were negative for anti-HIV. Regarding HBV markers, the prevalence of HBc antibodies was significantly higher among IVDA (62%) than the control group (27.5%). Also HBsAg was detected in 16% of IVDA while it was 75% among the control group. Prevalence of anti-HCV was significantly higher among IVDA (63%) than the control group (27.5%). The prevalence of co-infection with HBV and HCV was significantly higher in IVDA (40%) than the control group (15%). Sharing of needles and duration of drug use were positively associated with the presence of both HBV markers and anti-HCV. CMV seroprevalence was high in both groups. Antibodies to Syphilis were found in sera of 3 IVDA and one control using MHA-TP test. Although HIV infection has not yet been sufficiently introduced among IVDA in Alexandria but potentials for its spread among addicts are high as supported by observation that other infections with similar mode of transmission are common among addicts.
authors.affiliation: Department of Microbiology, Medical Research Institute, University of Alexandria.
authors.forename: E
authors.initials: E
authors.lastname: el-Ghazzawi
authors.forename: L
authors.initials: L
authors.lastname: Drew
authors.forename: L
authors.initials: L
authors.lastname: Hamdy
authors.forename: E
authors.initials: E
authors.lastname: El-Sherbini
authors.forename: S el-D
authors.initials: Sel-D
authors.lastname: Sadek
authors.forename: E
authors.initials: E
authors.lastname: Saleh
mesh_terms: D000328:Adult; D000914:Antibodies, Viral / Q000302:isolation & purification; D001424:Bacterial Infections / Q000453:epidemiology / Q000635:transmission*; D015415:Biomarkers; D016022:Case-Control Studies; D003586:Cytomegalovirus Infections / Q000453:epidemiology / Q000635:transmission*; D004534:Egypt / Q000453:epidemiology; D006679:HIV Seropositivity / Q000453:epidemiology / Q000635:transmission*; D006525:Hepatitis, Viral, Human / Q000453:epidemiology / Q000276:immunology / Q000635:transmission*; D006801:Humans; D008297:Male; D015995:Prevalence; D012306:Risk; D015819:Substance Abuse, Intravenous / Q000150:complications*; D014505:Urban Population
chemical_list: D000914:Antibodies, Viral; D015415:Biomarkers