Celiac disease presenting with motor neuropathy: effect of gluten free-diet.
Celiac disease is a rare cause of neuropathy that most commonly presents with symmetric distal sensory disturbances. We describe two patients with celiac disease in whom neuropathy presented unusually with progressive weakness of the limbs. In both patients a gluten-free diet induced a significant improvement of muscle strength and neurophysiological abnormalities, suggesting a direct pathogenetic role of sensitivity to gluten. Celiac disease should be considered in patients with idiopathic neuropathy even when gastrointestinal symptoms are absent.
Rigamonti
Andrea
A
Neuromuscular Diseases Unit, National Neurological Institute Carlo Besta, Via Celoria 11, 20133 Milan, Italy.
Magi
Stefania
S
Venturini
Elisabetta
E
Morandi
Lucia
L
Ciano
Claudia
C
Lauria
Giuseppe
G
D000328:Adult; D002446:Celiac Disease / Q000150:complications* / Q000175:diagnosis* / Q000178:diet therapy; D004032:Diet; D005260:Female; D005983:Glutens / Q000008:administration & dosage; D006801:Humans; D008875:Middle Aged; D016472:Motor Neuron Disease / Q000175:diagnosis* / Q000178:diet therapy / Q000209:etiology*
D005983:Glutens