title: Different isoforms of apolipoprotein AI present heterologous post-translational expression in HIV infected patients.
abstract: Human immunodeficiency virus (HIV) is rapidly becoming a global health concern. Proteomics technology was employed to examine HIV infected plasma samples in an attempt to identify disease-associated proteins. By comparison with normal and HIV positive plasma samples, at least eight proteins were significantly changed in HIV infected plasma. In particular, apolipoprotein AI presents a heterogeneous change in expression level with different isoforms. Apolipoprotein AI could be a useful biomarker for HIV diagnosis.
authors.affiliation: Department of Virology, National Institute of Health, Seoul 122-701, Korea.
authors.forename: Sung-Soon
authors.initials: SS
authors.lastname: Kim
authors.forename: Mi-Hye
authors.initials: MH
authors.lastname: Kim
authors.forename: Bo-Kyung
authors.initials: BK
authors.lastname: Shin
authors.forename: Han-Ju
authors.initials: HJ
authors.lastname: Na
authors.forename: Jin-Young
authors.initials: JY
authors.lastname: Choi
authors.forename: Mee-Kyung
authors.initials: MK
authors.lastname: Kee
authors.forename: Seon-Ah
authors.initials: SA
authors.lastname: Chong
authors.forename: Myeong-Jin
authors.initials: MJ
authors.lastname: Nam
mesh_terms: D015492:AIDS Serodiagnosis / Q000379:methods*; D016632:Apolipoprotein A-I / Q000737:chemistry*; D015415:Biomarkers / Q000737:chemistry*; D016022:Case-Control Studies; D015180:Electrophoresis, Gel, Two-Dimensional / Q000379:methods; D015658:HIV Infections / Q000097:blood*; D006679:HIV Seropositivity / Q000097:blood*; D006801:Humans; D010949:Plasma / Q000378:metabolism; D020033:Protein Isoforms; D011499:Protein Processing, Post-Translational; D040901:Proteomics / Q000379:methods; D020133:Reverse Transcriptase Polymerase Chain Reaction; D019562:Viral Load
chemical_list: D016632:Apolipoprotein A-I; D015415:Biomarkers; D020033:Protein Isoforms