Embryology and genetics of primary vesico-ureteric reflux and associated renal dysplasia.
Congenital anomalies of the kidney and urinary tract, as well as primary vesico-ureteric reflux (VUR) and associated renal dysplasia, are the most relevant causes of end-stage renal failure in the pediatric population. In vivo and in vitro experimental studies have allowed the identification of several genes involved both in ureteric bud branching, ureteric elongation and insertion into the bladder, and in nephrogenesis. It has been proposed that both renal and ureteral abnormalities, as well as the associated renal hypo-dysplasia, may derive from a common mechanism as the result of a dysregulation of the normal developmental program. The large homologies between mice and the human genome suggest that the same genes could be involved both in rodent and human VUR. Furthermore, epidemiological observations suggest that not only syndromic but also isolated VUR is an inherited trait. Linkage analysis for homologous mouse genes in humans, genome-wide linkage studies in multigenerational families and association studies by polymorphisms support the hypothesis that VUR is genetically heterogeneous and is caused by a number of different genes acting with random environmental effects. The present teaching paper is an overview of the embryology and genetics of primary VUR and associated congenital reflux nephropathy.
Murer
Luisa
L
Paediatric Nephrology, Dialysis and Transplant Unit, Department of Paediatrics, University of Padova, Padova, Italy. luisam@pediatria.unipd.it
Benetti
Elisa
E
Artifoni
Lina
L
D000818:Animals; D004195:Disease Models, Animal; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D007668:Kidney / Q000196:embryology; D051379:Mice; D021782:Multicystic Dysplastic Kidney / Q000150:complications / Q000196:embryology* / Q000235:genetics*; D014513:Ureter / Q000196:embryology; D014718:Vesico-Ureteral Reflux / Q000150:complications / Q000196:embryology* / Q000235:genetics*