title: Multilocular cystadenoma and cystadenocarcinoma of the prostate.
abstract: BACKGROUND
  Multicystic prostatic tumors are rare, with only a few reported cases of prostatic cystadenoma and cystadenocarcinoma in the scientific literature.
  
  
  METHODS
  A retrospective review of our tumor registry over the last 25 years identified 2 rare cystic tumors of the prostate: 1 multilocular cystadenoma and 1 multilocular cystadenocarcinoma.
  
  
  RESULTS
  The first case illustrates the clinical and pathologic features of prostatic multilocular cystadenoma. A 42-year-old man presented with a 16-cm suprapubic mass causing displacement of adjacent visceral organs. Pathologic examination after prostatectomy confirmed it to be a multilocular cystadenoma of the prostate. The patient's postoperative course was uneventful, and his serum prostate-specific antigen level remained at < or =0.04 ng/ml throughout the course of his disease. In the second case, we present an 80-year-old male presenting with a 12-cm cystic mass of the prostate. His serum prostate-specific antigen level remained at > or =9.0 ng/ml throughout the course of his disease. The tumor had an aggressive local growth pattern, with invasion into perirectal adipose tissue. This patient underwent a pelvic exenteration, followed by adjuvant systemic chemotherapy and complete androgen blockade. Despite aggressive treatment, he had 3 recurrences over 4 months but remains alive with disease at 23-month follow-up.
  
  
  CONCLUSIONS
  Cystadenocarcinoma of the prostate is locally aggressive and should be included in the differential diagnosis of cystic lesions of the prostate.
authors.affiliation: Department of Pathology, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA.
authors.forename: Tomasz
authors.initials: T
authors.lastname: Tuziak
authors.forename: Philippe E
authors.initials: PE
authors.lastname: Spiess
authors.forename: Neil A
authors.initials: NA
authors.lastname: Abrahams
authors.forename: Andrzej
authors.initials: A
authors.lastname: Wrona
authors.forename: Shi-Ming
authors.initials: SM
authors.lastname: Tu
authors.forename: Bogdan
authors.initials: B
authors.lastname: Czerniak
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003536:Cystadenocarcinoma / Q000473:pathology / Q000628:therapy*; D003537:Cystadenoma / Q000473:pathology / Q000628:therapy*; D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000473:pathology / Q000628:therapy*