Selection criteria for reduction hepatectomy in multiple advanced hepatocellular carcinoma.
BACKGROUND
Few studies have compared the prognostic impact of reduction hepatectomy (RH) for advanced hepatocellular carcinoma (HCC) with that of non-surgical treatment or curative hepatectomy.


METHODS
The treatment outcome of 30 RH patients was compared to that of two control groups: control group A, including 71 patients who underwent curative hepatectomy; control group B, including 106 patients who did not receive definitive local therapy or best supportive care.


RESULTS
In patients with tumor extension in >50% of the liver, 1-year survival rates for patients according to treatment (RH, control A and B) were 50%, 90% and 11% and 3-year survival rates were 42%, 60% and 0%, respectively. There was no significant difference between RH and control A, but there was a significant difference between RH and control B.


CONCLUSIONS
RH could be recommended to patients with multiple advanced HCC extending to >50% of the whole liver.
Gotohda
Naoto
N
Department of Hepatobiliary Pancreatic Surgery, National Cancer Center Hospital East, Chiba, 277-8577, Japan. ngotohda@east.ncc.go.jp
Ishii
Hiroshi
H
Konishi
Masaru
M
Nakagohri
Toshio
T
Takahashi
Shinichiro
S
Furuse
Junji
J
Yoshino
Masahiro
M
Kinoshita
Taira
T
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D006528:Carcinoma, Hepatocellular / Q000473:pathology / Q000601:surgery*; D005260:Female; D006498:Hepatectomy; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D018579:Patient Selection; D016896:Treatment Outcome