[Preparation and stability investigation of gastrodin dispersible tablets].
To prepare and optimize the gastrodin dispersible tablets by orthogonal design using the disintegration time as index. The quality of gastrodin dispersible tablets was evaluated by the initial stability test. The results showed that the disintegration time of optimized prescription formulation was 106s, i.e. L-HPC and CMS-Na was used by combining exterior and interior and the dissolution percent in vitro was obviously super to the conventional tablets. Moreover, the quality of the dispersible tablets was very well by stability test.
Xi
Yan-wei
YW
Department of Pharmacy, Shandong University, Jinan 250012, China.
Huang
Gui-hua
GH
Li
Lin-jun
LJ
D019540:Area Under Curve; D001592:Benzyl Alcohols / Q000008:administration & dosage* / Q000737:chemistry; D002626:Chemistry, Pharmaceutical; D004355:Drug Stability; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage* / Q000737:chemistry; D005960:Glucosides / Q000008:administration & dosage* / Q000737:chemistry; D007785:Lactose / Q000008:administration & dosage; D010592:Pharmaceutic Aids / Q000008:administration & dosage* / Q000737:chemistry / Q000145:classification; D010946:Plants, Medicinal / Q000737:chemistry*; D012995:Solubility; D013607:Tablets; D013678:Technology, Pharmaceutical / Q000379:methods*
D001592:Benzyl Alcohols; D004365:Drugs, Chinese Herbal; D005960:Glucosides; D010592:Pharmaceutic Aids; D013607:Tablets; C045345:gastrodin; D007785:Lactose