Characterization of a glucose sensor prepared by electropolymerization of pyrroles containing a tris-bipyridine osmium complex.
A glucose sensor was developed by electrocopolymerization using pyrroles containing a tris-bipyridine (bpy) osmium complex (Os-py), pyrrole (py), pyrrole propanoic acid (PPA) and glucose oxidase (GOx) to improve the key performance characteristics, such as the sensitivity, selectivity, and long-term stability. Tris-bipyridine osmium pyrrole complexes with four different methylene moieties were utilized to correlate the methylene length with the glucose sensor performance. The electrocatalytic response of glucose was clearly observed at electrodes modified with Os-py, except for the electrode immobilized with the Os-py complex containing the shortest methylene moiety. The current response to glucose increased up to a concentration of 100 mmol dm(-3). The electrocatalytic response to glucose at the [Os(bpy)(2)(py(6)-bpy)](2+/3+)/py/PPA/GOx electrode was stable for more than 100 days. Dissolved oxygen and potential interference compounds (ascorbic acid, uric acid, and acetaminophen) minimally perturbed the current response to glucose at the [Os(DM-bpy)(2)(py(6)-bpy)](2+/3+)/py/PPA/GOx electrode. Based on these results, a longer methylene moiety appears to improve the performance characteristics of a glucose sensor fabricated via the electropolymerization of tris-bipyridine osmium pyrrole complexes.
Tsujimoto
Masaki
M
Department of Chemical Science and Technology, Faculty of Engineering, The University of Tokushima, Japan.
Yabutani
Tomoki
T
Sano
Atsushi
A
Tani
Yuji
Y
Murotani
Hiroki
H
Mishima
Yuji
Y
Maruyama
Kenichi
K
Yasuzawa
Mikito
M
Motonaka
Junko
J
D015082:2,2'-Dipyridyl / Q000031:analogs & derivatives* / Q000737:chemistry; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D002138:Calibration; D002384:Catalysis; D002417:Cattle; D004563:Electrochemistry; D004566:Electrodes; D005947:Glucose / Q000032:analysis*; D007202:Indicators and Reagents; D009942:Organometallic Compounds / Q000737:chemistry*; D011108:Polymers / Q000138:chemical synthesis; D011758:Pyrroles / Q000737:chemistry*
D001786:Blood Glucose; D007202:Indicators and Reagents; D009942:Organometallic Compounds; D011108:Polymers; D011758:Pyrroles; D015082:2,2'-Dipyridyl; C085573:osmium bis(2,2'-bipyridine)chloride; D005947:Glucose