Dendritic cell biology during malaria.
Malaria is an infectious disease that causes serious morbidity and mortality worldwide. The disease is associated with a variety of clinical syndromes ranging from asymptomatic to lethal infections involving anaemia, organ failure, pulmonary and cerebral disease. The molecular and cellular factors responsible for the differences in disease severity are poorly understood but parasite-specific immune responses are thought to play a critical role in pathogenesis. Dendritic cells have an essential role in linking innate and adaptive immune responses and here we review their role in the context of malaria.
Wykes
Michelle
M
The Queensland Institute of Medical Research, The Bancroft Centre, 300 Herston Road, Brisbane, Qld 4006, Australia. Michelle.Wykes@qimr.edu.au
Keighley
Caitlin
C
Pinzon-Charry
Alberto
A
Good
Michael F
MF
D000818:Animals; D017951:Antigen Presentation / Q000276:immunology*; D003713:Dendritic Cells / Q000166:cytology / Q000276:immunology* / Q000469:parasitology; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology; D008288:Malaria / Q000276:immunology / Q000473:pathology*