[Effects of ligustrazine injection on lymph circulation in rats with acute microcirculation disturbance].
OBJECTIVE
To explore the interferential effect of ligustrazine injection (LI) on lymph circulation in rats with acute microcirculation disturbance (AMD).


METHODS
Sixteen Wistar male rats were divided into experimental and control groups. AMD was done by Dextran 500 injection from jugular vein and effects of LI on lymph circulation were observed in these rats by lymphatology methods.


RESULTS
During AMD phase, the contractility of mesenteric lymphatic (ML) , the intestinal lymph flux, lymphocytes out put were obviously decreased, and there was little monocytes in the lymph fluid, but the lymph fluid viscosity was increased. After treatment of LI, the contractility of ML, the intestinal lymph flux, lymphocytes out put was obvious increased. There was a lot of monocytes in the lymph fluid and the lymph fluid viscosity was decreased. There were signifcant difference compared with control group (P < 0.05).


CONCLUSIONS
LI can influence the recovery of AMD though enhancing the contractility of ML and the transport function of lymph circulation and decreasing lymph fluid viscosity.
Liu
Yan-kai
YK
Hebei North College, Zhangjiakou 075029, China. liuyk88@sina.com
Niu
Chun-yu
CY
Zhao
Zi-gang
ZG
Zhang
Yu-ping
YP
Du
Shu-ting
ST
Jiang
Hua
H
D000208:Acute Disease; D000818:Animals; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000494:pharmacology*; D007267:Injections; D008208:Lymphatic System / Q000098:blood supply* / Q000187:drug effects*; D008214:Lymphocytes / Q000187:drug effects; D008297:Male; D008643:Mesentery / Q000098:blood supply / Q000187:drug effects; D008833:Microcirculation / Q000187:drug effects; D009000:Monocytes / Q000187:drug effects; D010946:Plants, Medicinal / Q000737:chemistry; D011719:Pyrazines / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D004365:Drugs, Chinese Herbal; D011719:Pyrazines; C017953:tetramethylpyrazine