Targeting E2F1 death signaling: opposing role in cancer control and neurodegeneration.
As with many other molecular agents that are involved in multiple aspects of cellular processes, E2F1 plays a dual role of cellular proliferation and apoptosis. How to take advantage of the apoptosis induction and sensitization properties of E2F1 for therapeutic purposes while minimizing its other properties has a significant bearing on how to turn a functionally complex molecule such as E2F1 into a drug target.
Pützer
Brigitte M
BM
Department of Vectorology and Experimental Gene Therapy, Biomedical Research Center, University of Rostock, Schillingallee 69, D-18057 Rostock, Germany.
D000818:Animals; D017209:Apoptosis / Q000502:physiology; D050687:E2F1 Transcription Factor / Q000378:metabolism* / Q000502:physiology; D006801:Humans; D008954:Models, Biological; D009369:Neoplasms / Q000378:metabolism* / Q000503:physiopathology; D019636:Neurodegenerative Diseases / Q000378:metabolism* / Q000503:physiopathology; D015398:Signal Transduction / Q000502:physiology*
D050687:E2F1 Transcription Factor