title: Fat necrosis simulating recurrent neoplasia following external beam radiotherapy in a dog.
abstract: A 4.5-year-old neutered male dog was diagnosed with incompletely excised well-differentiated lymphangiosarcoma in the right inguinal subcutaneous region. The mass had metastasized to the right hypogastric and medial iliac lymph nodes. Surgery followed by definitive radiation therapy was administered to the primary site and the sites of metastasis. The dog had a complete response to radiotherapy, and minimal acute side effects. Doxorubicin was administered after radiotherapy. Approximately 4 months following radiation therapy, the dog developed a mass, presumed recurrent tumor, in the original site. In a biopsy only steatitis and fibrosis were found. The mass continued to grow and conservative surgical excision was elected. Histopathologically the diagnosis was fat necrosis and steatitis, with a microscopic focus of lymphangiosarcoma. Fat necrosis is an uncommon sequelum to breast irradiation in people and also appears to be rare in animals. Fat necrosis should be considered as a differential diagnosis when recurrent tumor is suspected in a previously irradiated subcutaneous site in a dog.
authors.affiliation: Department of Radiation Oncology, VCA Aurora Animal Hospital, 2600 West Galena Blvd, Aurora, IL, USA. jayme.looper@vcamail.com
authors.forename: Jayme S
authors.initials: JS
authors.lastname: Looper
mesh_terms: D000818:Animals; D003131:Combined Modality Therapy; D003937:Diagnosis, Differential; D004283:Dog Diseases / Q000175:diagnosis* / Q000532:radiotherapy; D004285:Dogs; D005218:Fat Necrosis / Q000175:diagnosis / Q000209:etiology / Q000662:veterinary*; D008204:Lymphangiosarcoma / Q000175:diagnosis / Q000662:veterinary; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis / Q000662:veterinary; D018714:Radiotherapy, Adjuvant / Q000009:adverse effects; D012878:Skin Neoplasms / Q000175:diagnosis / Q000662:veterinary