title: Salvage chemotherapy with carboplatin and paclitaxel for cisplatin-resistant thymic carcinoma--three cases.
abstract: The optimal chemotherapeutic regimen for thymic carcinoma remains uncertain and the utility of salvage therapy has also not been reported. Three cases of unresectable and locally advanced thymic carcinoma, resistant to prior chemotherapy with cisplatin are reported. These patients were treated with carboplatin and paclitaxel chemotherapy, as salvage chemotherapy. Although concomitant thoracic radiotherapy was performed in one patient, two showed a partial response and the other showed a minor response after carboplatin and paclitaxel chemotherapy. Thymic carcinoma is sensitive to platinum-based chemotherapy and paclitaxel appears to have significant activity against thymic carcinoma.
authors.affiliation: First Department of Internal Medicine, Shinshu University School of Internal Medicine, 3-1-1, Asahi Matsumoto, Japan.
authors.forename: Yoshimichi
authors.initials: Y
authors.lastname: Komatsu
authors.forename: Tomonobu
authors.initials: T
authors.lastname: Koizumi
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Tanabe
authors.forename: Orie
authors.initials: O
authors.lastname: Hatayama
authors.forename: Masanori
authors.initials: M
authors.lastname: Yasuo
authors.forename: Mitsuyo
authors.initials: M
authors.lastname: Okada
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yamamoto
authors.forename: Keishi
authors.initials: K
authors.lastname: Kubo
authors.forename: Mari
authors.initials: M
authors.lastname: Sasabayashi
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Tsunoda
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D016190:Carboplatin / Q000008:administration & dosage; D002945:Cisplatin / Q000494:pharmacology; D019008:Drug Resistance, Neoplasm; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017239:Paclitaxel / Q000008:administration & dosage; D016879:Salvage Therapy; D013953:Thymus Neoplasms / Q000188:drug therapy*
chemical_list: D016190:Carboplatin; D017239:Paclitaxel; D002945:Cisplatin