The effect of dimethylnitrosamine on the activities of renal prenolsulfotransferase and arylsulfatases A and B in Schistosona mansoni infected mice.
The activities of renal phenolsulfotransferase and arylsulfatases A and B were estimated in 400 male Swiss albino mice classified into four groups: Normal controls, Schistosoma mansoni infected group, Dimethylnitrosamine (DMN) treated group and infected treated group. The activity levels of the studied enzymes were significantly increased in all groups when compared with the control group, also the statistical analyses showed a high significant increase of the three enzymes levels in the infected treated group; when compared separately with treated or infected groups. It was concluded, therefore, that schistosomal infection is implicated in the development of kidney cancer which may arise from the pattern of hepatic mixed-function oxidase induction characterized for schistosomiasis and its temporal relationship with the procarcinogenic initiating events. Furthermore, the striking significant increase in the enzymatic activity levels of the acid hydrolases arylsulfatases due to the lesion of both cytotoxic effects of dimethylnitrosamine as well as pathological change of schistosomiasis which may play an active role in the initiation of the malignant process by detoxifying endogenous sulfated aromatic metabolites.
Hussein
N G
NG
Department of Applied Medical Chemistry, Medical Research Institute, Alexandria University, Egypt.
Saad
A A
AA
Hashem
S A
SA
El-Sewedy
S M
SM
D000818:Animals; D015239:Arylsulfotransferase / Q000378:metabolism*; D001711:Biotransformation; D015197:Carcinogenicity Tests; D002273:Carcinogens / Q000633:toxicity; D002553:Cerebroside-Sulfatase / Q000378:metabolism*; D003043:Cocarcinogenesis; D003600:Cytosol / Q000201:enzymology; D004128:Dimethylnitrosamine / Q000633:toxicity*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D007668:Kidney / Q000201:enzymology; D007677:Kidney Function Tests; D007680:Kidney Neoplasms / Q000139:chemically induced / Q000469:parasitology; D008247:Lysosomes / Q000201:enzymology; D008297:Male; D051379:Mice; D020051:N-Acetylgalactosamine-4-Sulfatase / Q000378:metabolism*; D012555:Schistosomiasis mansoni / Q000150:complications / Q000201:enzymology / Q000276:immunology; D013997:Time Factors
D002273:Carcinogens; D015239:Arylsulfotransferase; D020051:N-Acetylgalactosamine-4-Sulfatase; D002553:Cerebroside-Sulfatase; D004128:Dimethylnitrosamine