title: Intracranial infantile hemangiomas associated with PHACE syndrome.
abstract: OBJECTIVE
  Head and neck infantile hemangiomas are common lesions that are rarely observed in an intracranial location. We report 4 patients with orbital infantile hemangiomas and ipsilateral enhancing intracranial lesions, presumed to be infantile hemangiomas.
  
  
  METHODS
  Imaging studies and medical records of 4 infants with orbital hemangiomas and enhancing intracranial lesions were reviewed. The intracranial lesions were evaluated in terms of their location, signal intensity characteristics, enhancement pattern, and degree of involution following treatment. Additional findings associated with PHACE syndrome were also noted and a literature review of intracranial infantile hemangiomas and PHACE syndrome was also performed.
  
  
  RESULTS
  The intracranial masses were primarily in or adjacent to the internal auditory canal and demonstrated imaging characteristics and treatment response similar to the ipsilateral orbital lesions. Ipsilateral internal carotid artery hypoplasia, ipsilateral cerebellar hemisphere hypoplasia, and/or other head and neck hemangiomas were present in all patients.
  
  
  CONCLUSIONS
  These cases collectively support the diagnosis of intracranial infantile hemangiomas and suggest a unique radiographic association between PHACE syndrome and intracranial infantile hemangiomas.
authors.affiliation: Inland Imaging, Spokane, Washington 99202, USA.
authors.forename: C D
authors.initials: CD
authors.lastname: Judd
authors.forename: P R
authors.initials: PR
authors.lastname: Chapman
authors.forename: B
authors.initials: B
authors.lastname: Koch
authors.forename: C J
authors.initials: CJ
authors.lastname: Shea
mesh_terms: D000284:Administration, Oral; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000188:drug therapy; D002343:Carotid Artery, Internal / Q000002:abnormalities*; D002530:Cerebellopontine Angle / Q000473:pathology; D002531:Cerebellum / Q000002:abnormalities / Q000473:pathology; D004292:Dominance, Cerebral / Q000502:physiology; D005153:Facial Neoplasms / Q000175:diagnosis* / Q000188:drug therapy; D005260:Female; D006258:Head and Neck Neoplasms / Q000175:diagnosis* / Q000188:drug therapy; D006391:Hemangioma / Q000175:diagnosis* / Q000188:drug therapy; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D015552:Injections, Intralesional; D008279:Magnetic Resonance Imaging; D008297:Male; D009918:Orbital Neoplasms / Q000175:diagnosis* / Q000188:drug therapy; D011239:Prednisolone / Q000008:administration & dosage; D011241:Prednisone / Q000008:administration & dosage; D013577:Syndrome; D014057:Tomography, X-Ray Computed; D014221:Triamcinolone / Q000008:administration & dosage
chemical_list: D014221:Triamcinolone; D011239:Prednisolone; D011241:Prednisone