title: The genetic and environmental basis of hepatocellular carcinoma.
abstract: Liver cancer is among the most common malignancies, impacting significantly across all societies worldwide. The lethal impact of this prevalent cancer is unlikely to change considerably in the near future due to a limited understanding of disease pathogenesis on the molecular, cellular, and environmental levels and how current knowledge might be converted into new preventive, therapeutic and diagnostic approaches. This article highlights the current challenges and opportunities in this critical area of unmet need.
authors.affiliation: Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. pfarazi@mit.edu
authors.forename: Paraskevi A
authors.initials: PA
authors.lastname: Farazi
authors.forename: Ronald A
authors.initials: RA
authors.lastname: DePinho
mesh_terms: D016604:Aflatoxin B1 / Q000633:toxicity; D000437:Alcoholism / Q000150:complications; D006528:Carcinoma, Hepatocellular / Q000209:etiology*; D020022:Genetic Predisposition to Disease; D042822:Genomic Instability; D006526:Hepatitis C / Q000150:complications; D006801:Humans; D008113:Liver Neoplasms / Q000209:etiology*; D008954:Models, Biological
chemical_list: D016604:Aflatoxin B1