title: Adrenal function in 23 children with paracoccidioidomycosis.
abstract: Adrenal involvement by Paracoccidioides brasiliensis was described at necropsies and in many clinical studies, but only in adults. Therefore, the aim of this study was to evaluate adrenal function in children with paracoccidioidomycosis. Twenty-three children with the systemic form of paracoccidioidomycosis were evaluated and divided in two Groups: Group A (n = 8) included children before treatment and Group B (n = 15) children after the end of treatment. Plasma cortisol (basal and after ACTH test), ACTH, renin activity, aldosterone, sodium and potassium were measured. They were within normal range in all cases, except for renin activity and aldosterone, which were elevated in some cases. Group A patients showed basal and post-ACTH cortisol levels significantly greater than Group B patients. The results showed that adrenal function was not compromised in these children with paracoccidioidomycosis.
authors.affiliation: Departamento de Pediatria, Faculdade de Ciências Médicas, Universidade Estadual de Campinas, Rua Dr. Shigeo Mori 860, 13084-081 Campinas, São Paulo, Brazil. ricardom.p@uol.com.br
authors.forename: Ricardo Mendes
authors.initials: RM
authors.lastname: Pereira
authors.forename: Gil
authors.initials: G
authors.lastname: Guerra-Júnior
authors.forename: Antonia Terezinha
authors.initials: AT
authors.lastname: Tresoldi
mesh_terms: D015062:11-Hydroxycorticosteroids / Q000097:blood*; D000302:Adrenal Cortex / Q000378:metabolism / Q000503:physiopathology*; D000324:Adrenocorticotropic Hormone / Q000097:blood*; D002648:Child; D006801:Humans; D010229:Paracoccidioidomycosis / Q000097:blood / Q000503:physiopathology*; D011188:Potassium / Q000097:blood; D012083:Renin / Q000097:blood*; D012964:Sodium / Q000097:blood
chemical_list: D015062:11-Hydroxycorticosteroids; D000324:Adrenocorticotropic Hormone; D012964:Sodium; D012083:Renin; D011188:Potassium