title: [Insulin resistance and metabolic profile in lean and overweight/obese polycystic ovary syndrome patients].
abstract: OBJECTIVE
  To evaluate insulin sensitivity and the metabolic features in normal weight and overweight/obese patients with PCOS.
  
  
  METHODS
  Forty-nine (49) patients from 18 to 45 years were retrospectively evaluated and divided into 2 groups, according to the body mass index (BMI): group 1 (18.5-24.9 kg/m(2)) and group 2 (25-40 kg/m(2)). Collected data: systolic and diastolic blood pressure; fasting and after OGTT glucose, insulin and glucose/insulin ratio; area under the curve for glucose and insulin; HOMA-IR and HOMA-beta; lipidic profile; free (FT) and total testosterone (T) levels.
  
  
  RESULTS
  Greater averages of pressoric levels, insulin resistance (IR) indices, triglycerides and the FT levels, in addition to lower HDL levels, were found in group 2. Neither correlation between the IMC with none of data nor of the FT and IR indices with the lipid profile were found.
  
  
  CONCLUSIONS
  Obesity is associated with insulin resistance and diabetes mellitus in PCOS, independently on familiar history of DM. The absence of correlation between the IR indices and the FT with the lipidic profile suggests that other factors, such as the free fatty acids, can be involved in the pathogenesis of dyslipidemia in PCOS.
authors.affiliation: Instituto Estadual de Diabetes e Endocrinologia, Rio de Janeiro, RJ. vmkuba@uol.com.br
authors.forename: Valesca Mansur
authors.initials: VM
authors.lastname: Kuba
authors.forename: Patricia M
authors.initials: PM
authors.lastname: Cavalieri
authors.forename: Angela Casillo
authors.initials: AC
authors.lastname: Christóforo
authors.forename: Raul
authors.initials: R
authors.lastname: Faria Junior
authors.forename: Rosângela
authors.initials: R
authors.lastname: Caetano
authors.forename: Cláudia Medina
authors.initials: CM
authors.lastname: Coeli
authors.forename: Amanda
authors.initials: A
authors.lastname: Athayde
mesh_terms: D000293:Adolescent; D000328:Adult; D001794:Blood Pressure / Q000502:physiology; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D050171:Dyslipidemias / Q000209:etiology; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood / Q000378:metabolism*; D007333:Insulin Resistance / Q000502:physiology*; D050356:Lipid Metabolism / Q000502:physiology*; D008055:Lipids / Q000097:blood; D008875:Middle Aged; D009765:Obesity / Q000150:complications / Q000378:metabolism*; D011085:Polycystic Ovary Syndrome / Q000209:etiology / Q000378:metabolism*; D012189:Retrospective Studies; D018709:Statistics, Nonparametric
chemical_list: D007328:Insulin; D008055:Lipids