title: [Sleep and movement disorders].
abstract: The three different states of being (wakefulness, NREM and REM sleep) are associated with profound neurophysiological and neurochemical changes in the brain. These changes explain the existence of movement disorders appearing only or preferentially during sleep, and the effects of sleep on movement disorders. Sleep-related movement disorders are of clinical relevance for multiple reasons: 1) high frequency (e.g. restless legs syndrome (RLS)); 2) diagnostic relevance (e.g. REM sleep behavior disorder (RBD) as first manifestation of Parkinson disorder); 3) diagnostic uncertainty (e.g. parasomnias vs nocturnal epilepsy); 4) association with injuries (e.g. RBD, sleepwalking), sleep disruption/daytime sleepiness (e.g. RLS), and psycho-social burden (e.g. enuresis); 5) requirement of specific treatments (e.g. nocturnal epilepsy, stridor, RBD). This article gives an overview on clinical manifestations, pathophysiology, work-up and treatment of sleep-related movement disorders (e.g. RLS, bruxism), parasomnias (e.g. sleepwalking, RBD), sleep-related epilepsies, and on sleep-associated manifestations of movement disorders (e.g. Parkinson disease, multiple system atrophy).
authors.affiliation: Neurologische Klinik und Poliklinik, Universitätsspital Zürich.
authors.forename: R
authors.initials: R
authors.lastname: Poryazova
authors.forename: C L
authors.initials: CL
authors.lastname: Bassetti
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000927:Anticonvulsants / Q000627:therapeutic use; D002012:Bruxism / Q000175:diagnosis; D002648:Child; D003937:Diagnosis, Differential; D020820:Dyskinesias; D004569:Electroencephalography; D017034:Epilepsy, Frontal Lobe / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009069:Movement Disorders / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology; D019578:Multiple System Atrophy / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology; D020189:Nocturnal Myoclonus Syndrome / Q000175:diagnosis / Q000503:physiopathology; D020447:Parasomnias / Q000175:diagnosis / Q000503:physiopathology; D010300:Parkinson Disease / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology; D017286:Polysomnography; D012148:Restless Legs Syndrome / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology; D020188:Sleep Paralysis / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology; D012894:Sleep Stages; D012893:Sleep Wake Disorders / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology; D012895:Sleep, REM; D013009:Somnambulism
chemical_list: D000927:Anticonvulsants