title: Effect of sitaxsentan treatment on quality of life in pulmonary arterial hypertension.
abstract: In recent years new therapeutic options have been developed for the management of pulmonary arterial hypertension (PAH). Sitaxsentan is an oral, once daily, highly selective endothelin A receptor antagonist that recently demonstrated a positive effect on functional capacity and haemodynamics of PAH patients. The aim of this study is to evaluate the effect of sitaxsentan in the quality of life (QOL) of PAH patients. Twenty-three patients with idiopathic PAH or PAH associated to collagen vascular diseases were evaluated at baseline and after 16 weeks of treatment with sitaxsentan 100 mg orally, once daily. 6-min walk test distance (6MWD) and QOL questionnaire (QOLQ) (SF-36) were obtained at baseline and at week 16. There was a significant improvement in functional capacity evaluated by 6MWD (472 m vs. 490 m, p = 0.03) and also in the physical component of the QOLQ (p < 0.01). Evaluating each of the domains of the SF-36 QOLQ, those more related to physical capacity presented a significant increase while the domains related to the mental component presented a trend of improvement, without reaching statistical significance. Sitaxsentan improves QOL in patients with PAH mainly through the domains related to functional capacity.
authors.affiliation: Pulmonary Division, Pulmonary Hypertension Unit, University of São Paulo Medical School, Sao Paulo, Brazil. rogério.souza@incor.usp.br
authors.forename: R
authors.initials: R
authors.lastname: Souza
authors.forename: B C S
authors.initials: BC
authors.lastname: Martins
authors.forename: C
authors.initials: C
authors.lastname: Jardim
authors.forename: F
authors.initials: F
authors.lastname: Cortopassi
authors.forename: C J C
authors.initials: CJ
authors.lastname: Fernandes
authors.forename: T
authors.initials: T
authors.lastname: Pulido
authors.forename: J
authors.initials: J
authors.lastname: Sandoval
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000959:Antihypertensive Agents / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000188:drug therapy*; D007555:Isoxazoles / Q000008:administration & dosage*; D008297:Male; D011788:Quality of Life; D013876:Thiophenes / Q000008:administration & dosage*
chemical_list: D000959:Antihypertensive Agents; D007555:Isoxazoles; D013876:Thiophenes; C106276:sitaxsentan