title: Effects of antidepressant treatment on cognitive performance in elderly subjects with heart failure and comorbid major depression: an exploratory study.
abstract: Cognitive deficits are common in association with heart failure (HF), and it is possible that their severity is magnified by the concomitant presence of major depressive disorder (MDD). Using the Cambridge Mental Disorders of the Elderly Examination battery, the authors compared the cognitive performance of MDD-HF subjects (N=20), nondepressed HF subjects (N=23), and healthy control subjects (N=18). Scores were lower in both HF groups relative to control subjects. In the MDD-HF group, there were significant cognitive improvements after antidepressant treatment. Cognitive impairment is, therefore, significant in HF subjects with or without comorbid MDD, and it is important to recognize and treat MDD symptoms associated with HF.
authors.affiliation: Department of Psychiatry, University of São Paulo Medical School, São Paulo, Brazil. tania_alves@hotmail.com
authors.forename: Tânia C T F
authors.initials: TC
authors.lastname: Alves
authors.forename: Jairo
authors.initials: J
authors.lastname: Rays
authors.forename: Renata M S
authors.initials: RM
authors.lastname: Telles
authors.forename: Renério Fráguas
authors.initials: RF
authors.lastname: Júnior
authors.forename: Mauricio
authors.initials: M
authors.lastname: Wajngarten
authors.forename: Belkiss W
authors.initials: BW
authors.lastname: Romano
authors.forename: Cintia
authors.initials: C
authors.lastname: Watanabe
authors.forename: Geraldo F
authors.initials: GF
authors.lastname: Busatto
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000928:Antidepressive Agents / Q000009:adverse effects / Q000627:therapeutic use*; D018687:Antidepressive Agents, Second-Generation / Q000627:therapeutic use*; D015283:Citalopram / Q000009:adverse effects / Q000627:therapeutic use*; D003072:Cognition Disorders / Q000150:complications / Q000175:diagnosis* / Q000523:psychology; D003865:Major Depressive Disorder / Q000150:complications / Q000188:drug therapy* / Q000523:psychology; D005260:Female; D015577:Geriatric Assessment; D006333:Heart Failure / Q000150:complications / Q000523:psychology*; D006801:Humans; D008297:Male; D008609:Mental Status Schedule / Q000706:statistics & numerical data; D009483:Neuropsychological Tests; D011594:Psychometrics; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use*; D020280:Sertraline / Q000009:adverse effects / Q000627:therapeutic use*; D016896:Treatment Outcome; D018487:Ventricular Dysfunction, Left / Q000150:complications / Q000523:psychology*
chemical_list: D000928:Antidepressive Agents; D018687:Antidepressive Agents, Second-Generation; D015283:Citalopram; D017367:Selective Serotonin Reuptake Inhibitors; D020280:Sertraline