title: Increase in soluble CD138 in bronchoalveolar lavage fluid of multicentric Castleman's disease.
abstract: Multicentric Castleman's disease (MCD) is a rare and often incurable lymphoproliferative disorder. It is typically a systemic illness, but occasionally manifests primarily as a pulmonary parenchymal disease with massive infiltration of CD138 (syndecan-1)-positive plasma cells. This is the first report to demonstrate a marked elevation of soluble CD138, despite the absence of plasma cells, in BAL fluid in an MCD patient with pulmonary involvement. This finding suggests that the quantitative measurement of soluble CD138 in BAL fluid may reflect plasma cell infiltration and disease activity in the lungs of patients with MCD.
authors.affiliation: First Department of Medicine, Hokkaido University School of Medicine, Sapporo, Japan.
authors.forename: Masaru
authors.initials: M
authors.lastname: Hasegawa
authors.forename: Tomoko
authors.initials: T
authors.lastname: Betsuyaku
authors.forename: Nobuya
authors.initials: N
authors.lastname: Yoshida
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Nasuhara
authors.forename: Ichiro
authors.initials: I
authors.lastname: Kinoshita
authors.forename: Satoshi
authors.initials: S
authors.lastname: Ohta
authors.forename: Tomoo
authors.initials: T
authors.lastname: Itoh
authors.forename: Pyong Woo
authors.initials: PW
authors.lastname: Park
authors.forename: Masaharu
authors.initials: M
authors.lastname: Nishimura
mesh_terms: D015415:Biomarkers / Q000378:metabolism; D001707:Biopsy, Needle; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry* / Q000166:cytology; D005871:Castleman Disease / Q000150:complications / Q000175:diagnosis / Q000378:metabolism*; D002452:Cell Count; D003937:Diagnosis, Differential; D018450:Disease Progression; D005500:Follow-Up Studies; D006801:Humans; D007668:Kidney / Q000473:pathology; D017563:Lung Diseases, Interstitial / Q000150:complications / Q000175:diagnosis / Q000378:metabolism*; D008198:Lymph Nodes / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010950:Plasma Cells; D035583:Rare Diseases; D012720:Severity of Illness Index; D053668:Syndecan-1 / Q000378:metabolism*; D014057:Tomography, X-Ray Computed
chemical_list: D015415:Biomarkers; C508241:SDC1 protein, human; D053668:Syndecan-1