title: Proteasome-independent functions of ubiquitin in endocytosis and signaling.
abstract: Ubiquitination is a reversible posttranslational modification of cellular proteins, in which a 76-amino acid polypeptide, ubiquitin, is primarily attached to the epsilon-amino group of lysines in target proteins. Ubiquitination is a major player in regulating a broad host of cellular processes, including cell division, differentiation, signal transduction, protein trafficking, and quality control. Aberrations in the ubiquitination system are implicated in pathogenesis of some diseases, certain malignancies, neurodegenerative disorders, and pathologies of the inflammatory immune response. Here, we discuss the proteasome-independent roles of ubiquitination in signaling and endocytosis.
authors.affiliation: Department of Biochemistry, University of Geneva, 30 Quai Ernest Ansermet, CH-1211 Geneva, Switzerland.
authors.forename: Debdyuti
authors.initials: D
authors.lastname: Mukhopadhyay
authors.forename: Howard
authors.initials: H
authors.lastname: Riezman
mesh_terms: D000818:Animals; D004261:DNA Replication; D004194:Disease; D004705:Endocytosis; D011992:Endosomes / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D009369:Neoplasms / Q000378:metabolism; D019636:Neurodegenerative Diseases / Q000378:metabolism; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism; D021382:Protein Sorting Signals; D021381:Protein Transport; D011506:Proteins / Q000378:metabolism*; D015398:Signal Transduction; D014158:Transcription, Genetic; D025801:Ubiquitin / Q000378:metabolism*
chemical_list: D021382:Protein Sorting Signals; D011506:Proteins; D025801:Ubiquitin; D046988:Proteasome Endopeptidase Complex