title: Enantioselective total synthesis of (+)-gliocladin C.
abstract: The first total synthesis of gliocladin C, a fungal-derived marine alkaloid containing a rare trioxopiperazine fragment, is reported. This asymmetric synthesis establishes the absolute configuration of this structurally novel natural product. [reaction: see text].
authors.affiliation: Department of Chemistry, 1102 Natural Sciences II, University of California, Irvine, California 92697-2025, USA. leoverma@uci.edu
authors.forename: Larry E
authors.initials: LE
authors.lastname: Overman
authors.forename: Youseung
authors.initials: Y
authors.lastname: Shin
mesh_terms: D000470:Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry; D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry; D008968:Molecular Conformation; D010879:Piperazines / Q000138:chemical synthesis* / Q000737:chemistry; D011760:Pyrrolidinones / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000470:Alkaloids; D001688:Biological Products; D010879:Piperazines; D011760:Pyrrolidinones; C518056:gliocladin C