title: Increased incidence of cytomegalovirus retinitis after allogeneic hematopoietic stem cell transplantation.
abstract: Six cases of cytomegalovirus retinitis (CMVR) after allogeneic hematopoietic stem cell transplantation were diagnosed between 2002 and 2005 in our center, whereas only one case was diagnosed between 1985 and 2001. Cumulative incidence reaches 2.2%, whereas this complication has been rarely described after hematopoietic stem cell transplantation. We aimed to describe clinical and biologic features of CMVR and search for risk factors associated with CMVR. CMVR was diagnosed on specific funduscopic examination in all patients either on visual symptoms (n=3) or on systematic ophthalmologic examination (n=3). CMVR occurred in the context of unrelated transplantation in patients with profound immune defect and multiple episodes of cytomegalovirus (CMV) reactivation. The combination of a CMV-seropositive recipient and CMV-seronegative donor was the leading risk factor.
authors.affiliation: Service d'Hématologie-Transplantation, Hôpital Saint-Louis, Paris, France.
authors.forename: Aliénor
authors.initials: A
authors.lastname: Xhaard
authors.forename: Marie
authors.initials: M
authors.lastname: Robin
authors.forename: Catherine
authors.initials: C
authors.lastname: Scieux
authors.forename: Régis Peffault
authors.initials: RP
authors.lastname: de Latour
authors.forename: Sylvie
authors.initials: S
authors.lastname: Deplus
authors.forename: Marie-Christine
authors.initials: MC
authors.lastname: Mazeron
authors.forename: Agnès
authors.initials: A
authors.lastname: Devergie
authors.forename: Hélène
authors.initials: H
authors.lastname: Espérou
authors.forename: Vanderson
authors.initials: V
authors.lastname: Rocha
authors.forename: Eliane
authors.initials: E
authors.lastname: Gluckman
authors.forename: Patricia
authors.initials: P
authors.lastname: Ribaud
authors.forename: Gérard
authors.initials: G
authors.lastname: Socié
mesh_terms: D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use*; D002675:Child, Preschool; D017726:Cytomegalovirus Retinitis / Q000453:epidemiology*; D024882:Drug Resistance, Viral; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D015994:Incidence; D012189:Retrospective Studies
chemical_list: D000998:Antiviral Agents