title: Interleukin-6 gene amplification and shortened survival in glioblastoma patients.
abstract: Interleukin-6 (IL-6) is known to promote tumour growth and survival. We evaluated IL-6 gene amplification in tumours from 53 glioma patients using fluorescence in situ hybridisation. Amplification events were detected only in glioblastomas (15 out of 36 cases), the most malignant tumours, and were significantly associated with decreased patient survival.
authors.affiliation: EA 3846, Université d'Auvergne, Clermont-Ferrand, F-63001, France. andrei.tchirkov@cjp.fr
authors.forename: A
authors.initials: A
authors.lastname: Tchirkov
authors.forename: T
authors.initials: T
authors.lastname: Khalil
authors.forename: E
authors.initials: E
authors.lastname: Chautard
authors.forename: K
authors.initials: K
authors.lastname: Mokhtari
authors.forename: L
authors.initials: L
authors.lastname: Véronèse
authors.forename: B
authors.initials: B
authors.lastname: Irthum
authors.forename: P
authors.initials: P
authors.lastname: Vago
authors.forename: J-L
authors.initials: JL
authors.lastname: Kémény
authors.forename: P
authors.initials: P
authors.lastname: Verrelle
mesh_terms: D005784:Gene Amplification; D005909:Glioblastoma / Q000235:genetics* / Q000401:mortality; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D015850:Interleukin-6 / Q000235:genetics*
chemical_list: D015850:Interleukin-6