Primary myelofibrosis (PMF), post polycythemia vera myelofibrosis (post-PV MF), post essential thrombocythemia myelofibrosis (post-ET MF), blast phase PMF (PMF-BP): Consensus on terminology by the international working group for myelofibrosis research and treatment (IWG-MRT).
The International Working Group for Myelofibrosis Research and Treatment (IWG-MRT) is comprised of hematologists, hematopathologists, and laboratory scientists and its main goal is to provide a forum for scientific exchange and collaboration. During its first general meeting in April 2006, the IWG-MRT established uniform treatment response criteria for chronic idiopathic myelofibrosis (CIMF); also known as agnogenic myeloid metaplasia (AMM), myelofibrosis with myeloid metaplasia (MMM), and many other names in the hematologic literature. This document summarizes the proceedings from the second meeting of the IWG-MRT, in November 2006, where the group discussed and agreed to standardize the nomenclature referring to CIMF: (i) the term primary myelofibrosis (PMF) was chosen over several other designations including CIMF, AMM, and MMM, (ii) myelofibrosis that develops in the setting of either polycythemia vera (PV) or essential thrombocythemia (ET) will be referred to as post-PV MF and post-ET MF, respectively, and (iii) "leukemic" transformation will be recognized as blast phase disease (PMF-BP, post-PV/ET MF in blast phase).
Mesa
Ruben A
RA
Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
Verstovsek
Srdan
S
Cervantes
Francisco
F
Barosi
Giovanni
G
Reilly
John T
JT
Dupriez
Brigitte
B
Levine
Ross
R
Le Bousse-Kerdiles
Marie-Caroline
MC
Wadleigh
Martha
M
Campbell
Peter J
PJ
Silver
Richard T
RT
Vannucchi
Alessandro M
AM
Deeg
H Joachim
HJ
Gisslinger
Heinz
H
Thomas
Deborah
D
Odenike
Olatoyosi
O
Solberg
Lawrence A
LA
Gotlib
Jason
J
Hexner
Elizabeth
E
Nimer
Stephen D
SD
Kantarjian
Hagop
H
Orazi
Attilio
A
Vardiman
James W
JW
Thiele
Juergen
J
Tefferi
Ayalew
A
D001752:Blast Crisis / Q000145:classification / Q000473:pathology; D002471:Cell Transformation, Neoplastic / Q000145:classification / Q000473:pathology; D002908:Chronic Disease; D006801:Humans; D011087:Polycythemia Vera / Q000145:classification / Q000473:pathology; D055728:Primary Myelofibrosis / Q000145:classification / Q000473:pathology; D009626:Terminology as Topic; D013920:Thrombocythemia, Essential / Q000145:classification / Q000473:pathology