title: Evaluation of anti-inflammatory activity of Calotropis gigantea (AKANDA) in various biological system.
abstract: To evaluate the effect of Calotropis G in various experimental animal models. The anti-inflammatory activity was evaluated using carrageenin-induced kaolin -induced rat paw oedema for acute and cotton-pellet granuloma, adjuvant-induced arthritis model for chronic inflammation. Antipyretic activity was carried out using yeast induced pyresis method. Phenylquinone--induced writhing method in mice was used for analgesic activity. Test compounds exhibited variable anti-inflammatory activity and peak activity of the test compounds were reached at 2 h. Alkaloid fraction possesses comparatively high initial anti-inflammatory activity. The residual anti-inflammatory activity of alkaloid fraction of Calotropis G suggest either a greater protein binding nature of the compound there by providing a slow released pool of active drug molecule in the system or non available of possible bioactive metabolites to retain the activity profile relation.
authors.affiliation: Department of Biochemistry, National Medical College Teaching Hospital, Birgunj, Nepal. mradak1962@yahoo.co.in
authors.forename: Manoranjan
authors.initials: M
authors.lastname: Adak
authors.forename: Joyanta Kumar
authors.initials: JK
authors.lastname: Gupta
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001169:Arthritis, Experimental / Q000188:drug therapy* / Q000503:physiopathology; D031107:Calotropis; D002908:Chronic Disease; D004487:Edema / Q000188:drug therapy* / Q000209:etiology; D006705:Homeopathy; D007249:Inflammation / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D051379:Mice; D023421:Models, Animal; D010653:Phenylbutazone / Q000494:pharmacology / Q000627:therapeutic use; D010936:Plant Extracts / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats
chemical_list: D000893:Anti-Inflammatory Agents; D010936:Plant Extracts; D010653:Phenylbutazone