title: [Two cases of inoperable gastric cancer successively treated with TS-1+CDDP as neoadjuvant chemotherapy].
abstract: CASE 1: A 30-year-old male with a loss of appetite and hematemesis was diagnosed with scirrhous gastric cancer upon detailed examination. Laparoscopic biopsy showed it to be Group V. Pre-operative diagnosis was T3N3P1HOM1, Stage V. Three courses of pre-operative chemotherapy (NAC) of TS-1+CDDP were performed. Laparoscopic examination as well as imaging showed a clear reduction in tumor size. Total gastrectomy, resection of the small intestine and cholecystectomy were performed. Pathological findings were type 4, por 2, pT3 (ss), ly1, v0, pN0, pM1 (gall bladder, small intestine): pStage IV. CASE 2: A 55-year-old male with epigastric pain was diagnosed with scirrhous gastric cancer upon detailed examination. Pre-operative diagnosis was T3N1P1H0M0, Stage IIIA. Upon surgery, gastro-jejunal anastomosis was performed as resection was not an optional. Three courses of TS-1+CDDP were performed. A clear reduction of tumor size was noted upon laparoscopic examination as well as imaging and distal gastrectomy was performed. The pathological findings shown were type 4, por 2, pT3 (ss), ly2, v1, pN1, p1, pStage IV. The prognosis for inoperable gastric cancer is not promising and there is no established treatment guideline, however, there are cases in which TS-1+CDDP therapy has made surgery possible, and with the anticipation of extended survival, can be considered a useful therapy method.
authors.affiliation: Dept. of Surgery, Nikko Memorial Hospital.
authors.forename: Joji
authors.initials: J
authors.lastname: Takada
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Katsuki
authors.forename: Hiromi
authors.initials: H
authors.lastname: Hamada
authors.forename: Yasushige
authors.initials: Y
authors.lastname: Tsuji
mesh_terms: D000328:Adult; D000714:Anastomosis, Surgical; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002763:Cholecystectomy; D002945:Cisplatin / Q000008:administration & dosage; D005743:Gastrectomy; D006801:Humans; D007421:Intestine, Small / Q000601:surgery; D007583:Jejunum / Q000601:surgery; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D013270:Stomach / Q000601:surgery; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D005641:Tegafur / Q000008:administration & dosage
chemical_list: D005641:Tegafur; D002945:Cisplatin