[c-FOS protein expression in cells of the variuos hypothalamic structures after electric pain stimulation and injections of antigens].
Hypothalamic structures become activated after stimul. Alteration of c-Fos-positive cells quantity in different hypothalamic structures after electric pain stimulation (EPS), intravenous (iv) injection of antigens (lioppolysaccharide (LPS) and bovine serum albumir (BSA)) was detected with immunohistochemical method. EPS and iv injection of antigens (LPS and BSA) result in c-Fos-positive cells quantity increase in all observed hypothalamic structures. The highest activation level was in AHN and PH after EPS and in AHN, PVH, LHA-28, and PH after iv LPS injection. Comparative analysis of results showed, that c-Fos-positive cells quantity increase after EPS in AHN, PVH, LHA and PH was more significant than after iv injection of antigens (LPS and BSA). LPS injection results in more pronounced cell activation in AHN, PVH, LHA-28 and DMH (according to quantity of c-Fos-positive cells), than BSA injection.
Gavrilov
Iu V
IuV
Perekrest
S V
SV
Novikova
N S
NS
D000818:Animals; D004558:Electric Stimulation; D007031:Hypothalamus / Q000378:metabolism* / Q000503:physiopathology; D008070:Lipopolysaccharides / Q000276:immunology; D008297:Male; D009474:Neurons / Q000502:physiology*; D010146:Pain / Q000276:immunology / Q000503:physiopathology*; D016760:Proto-Oncogene Proteins c-fos / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D012710:Serum Albumin, Bovine / Q000276:immunology
D008070:Lipopolysaccharides; D016760:Proto-Oncogene Proteins c-fos; C036757:lipopolysaccharide B; D012710:Serum Albumin, Bovine