Tri- and hexavalent mannoside clusters as potential inhibitors of type 1 fimbriated bacteria using pentaerythritol and triazole linkages.
Several oligomannoside clusters having a hundred-fold increase in affinities toward E. coli were synthesized by Cu(I)-catalyzed [1,3]-dipolar cycloadditions using pentaerythritol scaffolds bearing either alkyne or azide functionalities.
Touaibia
Mohamed
M
Department of Chemistry, Université du Québec à Montréal, PO Box 8888, Succ. Centre-Ville Montreal, Québec, Canada H3C 3P8.
Shiao
Tze Chieh
TC
Papadopoulos
Alex
A
Vaucher
Jonathan
J
Wang
Qingan
Q
Benhamioud
Karima
K
Roy
René
R
D004926:Escherichia coli / Q000737:chemistry* / Q000378:metabolism*; D008362:Mannosides / Q000096:biosynthesis* / Q000737:chemistry*; D015394:Molecular Structure; D011409:Propylene Glycols / Q000737:chemistry*; D014230:Triazoles / Q000737:chemistry*
D008362:Mannosides; D011409:Propylene Glycols; D014230:Triazoles; C008783:pentaerythritol