title: Large-scale synthesis of immunoactivating natural product, pristane, by continuous microfluidic dehydration as the key step.
abstract: An efficient protocol of dehydration was developed under microfluidic conditions. The method was applied to a multikilogram synthesis of pristane, a biologically important natural product, which is now widely used as an adjuvant for monoclonal antibody production. [reaction: see text].
authors.affiliation: Department of Chemistry, Graduate School of Science, Osaka University, Machikaneyama 1-1, Toyonaka, Osaka 560-0043, Japan.
authors.forename: Katsunori
authors.initials: K
authors.lastname: Tanaka
authors.forename: Shinya
authors.initials: S
authors.lastname: Motomatsu
authors.forename: Koichi
authors.initials: K
authors.lastname: Koyama
authors.forename: Shin-ichi
authors.initials: S
authors.lastname: Tanaka
authors.forename: Koichi
authors.initials: K
authors.lastname: Fukase
mesh_terms: D001685:Biological Factors / Q000138:chemical synthesis* / Q000737:chemistry; D003681:Dehydration; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation / Q000379:methods*; D015394:Molecular Structure; D012680:Sensitivity and Specificity; D013729:Terpenes / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D001685:Biological Factors; D013729:Terpenes; C009042:pristane