title: Dietary supplementation with an extract of lycopene-rich tomatoes does not reduce atherosclerosis in Watanabe Heritable Hyperlipidemic rabbits.
abstract: Tomatoes are rich in lycopene and other carotenoids which have shown beneficial effects on CVD in epidemiological and intervention studies. In the present study the effect of an extract of lycopene-rich tomatoes, Lyc-O-Mato on atherosclerosis was studies in Watanabe Heritable Hyperlipidemic rabbits. The rabbits were fed a control diet, a control diet supplemented with the tomato extract or a control diet supplemented with a mixture of plant oils for 16 weeks. Lycopene was detected only in plasma of rabbits receiving tomato extract. The tomato extract had no effect on cholesterol and triacylglycerol levels measured in total plasma, lipoprotein fractions and on aortic atherosclerosis evaluated biochemically and by microscopy. Oxidation of lipids in unfractionated plasma also was unaffected by the intake of tomato extract. In conclusion, the tomato extract increased plasma levels of lycopene in rabbits, but had no effect on hypercholesterolaemia, oxidation of plasma lipids or aortic atherosclerosis.
authors.affiliation: Danish Institute for Food and Veterinary Research, Bygade, Soborg, Denmark. haf@dfvf.dk
authors.forename: Hanne
authors.initials: H
authors.lastname: Frederiksen
authors.forename: Salka E
authors.initials: SE
authors.lastname: Rasmussen
authors.forename: Malene
authors.initials: M
authors.lastname: Schrøder
authors.forename: Anette
authors.initials: A
authors.lastname: Bysted
authors.forename: Jette
authors.initials: J
authors.lastname: Jakobsen
authors.forename: Henrik
authors.initials: H
authors.lastname: Frandsen
authors.forename: Gitte
authors.initials: G
authors.lastname: Ravn-Haren
authors.forename: Alicja
authors.initials: A
authors.lastname: Mortensen
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage* / Q000032:analysis; D001011:Aorta / Q000737:chemistry; D001018:Aortic Diseases / Q000209:etiology / Q000473:pathology*; D050197:Atherosclerosis / Q000209:etiology / Q000473:pathology*; D002338:Carotenoids / Q000008:administration & dosage* / Q000097:blood; D002784:Cholesterol / Q000032:analysis / Q000097:blood; D019587:Dietary Supplements; D006950:Hyperlipidemia, Familial Combined / Q000097:blood / Q000150:complications / Q000178:diet therapy*; D015227:Lipid Peroxidation; D008074:Lipoproteins / Q000737:chemistry; D000077276:Lycopene; D018551:Solanum lycopersicum; D008297:Male; D023421:Models, Animal; D010936:Plant Extracts / Q000008:administration & dosage; D011817:Rabbits; D011897:Random Allocation; D017211:Treatment Failure; D014280:Triglycerides / Q000032:analysis / Q000097:blood
chemical_list: D000975:Antioxidants; D008074:Lipoproteins; D010936:Plant Extracts; D014280:Triglycerides; D002338:Carotenoids; D002784:Cholesterol; D000077276:Lycopene