A role for pancreatic polypeptide in feeding and body weight regulation.
PP administration induces negative energy balance by suppressing food intake and gastric emptying while increasing energy expenditure in rodents. The mechanism of PP actions involves the changes in the expression of hypothalamic feeding-regulatory peptides and the activity of the vago-vagal and vago-sympathetic reflex arc. PP-overexpressing mice we developed exhibited the thin phenotype with decreased food intake and gastric emptying rate. Plasma cholecystokinin (CCK) concentrations were increased in the transgenic mice and CCK-1 receptor antagonist improved the anorexia of the animals. These results, together with the previous notion of PP as an anti-CCK hormone in pancreatic exocrine secretion and gallbladder contraction, indicate that PP-CCK interactions may be either antagonistic or synergistic and the transgenic mice may exhibit the mixed phenotype by overproduction of PP and CCK.
Kojima
Shinya
S
Department of Behavioral Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1, Sakuragaoka, Kagoshima-City 890-8520, Japan.
Ueno
Naohiko
N
Asakawa
Akihiro
A
Sagiyama
Kenichirou
K
Naruo
Tetsuro
T
Mizuno
Shigeto
S
Inui
Akio
A
D000818:Animals; D001835:Body Weight; D005247:Feeding Behavior / Q000502:physiology*; D051379:Mice; D008822:Mice, Transgenic; D010191:Pancreatic Polypeptide / Q000502:physiology*; D017476:Receptors, Neuropeptide Y / Q000235:genetics / Q000502:physiology
D017476:Receptors, Neuropeptide Y; C109491:neuropeptide Y4 receptor; D010191:Pancreatic Polypeptide