title: Cerebrospinal fluid anti-SSA autoantibodies in primary Sjogren's syndrome with central nervous system involvement.
abstract: BACKGROUND
  Central nervous system involvement in primary Sjogren's syndrome is a matter of controversy, and its diagnosis remains difficult.
  
  
  METHODS
  We report 3 patients with primary Sjogren's syndrome and central nervous system involvement in whom we assessed intrathecal immunoglobulin G synthesis and the presence of cerebrospinal fluid anti-SSA and anti-SSB autoantibodies.
  
  
  RESULTS
  We found intrathecal immunoglobulin G synthesis and presence of cerebrospinal fluid anti-SSA autoantibodies in all patients, with demonstration for the first time of specific anti-SSA autoantibody intrathecal synthesis in 2 patients.
  
  
  CONCLUSIONS
  We suggest that cerebrospinal fluid anti-SSA autoantibodies could serve as a biomarker for Sjogren's-syndrome-related central nervous system involvement.
authors.affiliation: Service of Neurology, Department of Clinical Neuroscience and Dermatology, Geneva University Hospital and School of Medicine, Geneva, Switzerland. pierre.megevand@medecine.unige.ch
authors.forename: Pierre
authors.initials: P
authors.lastname: Mégevand
authors.forename: Carlo
authors.initials: C
authors.lastname: Chizzolini
authors.forename: Michel
authors.initials: M
authors.lastname: Chofflon
authors.forename: Pascale
authors.initials: P
authors.lastname: Roux-Lombard
authors.forename: Patrice H
authors.initials: PH
authors.lastname: Lalive
authors.forename: Fabienne
authors.initials: F
authors.lastname: Picard
mesh_terms: D000974:Antibodies, Antinuclear / Q000097:blood / Q000134:cerebrospinal fluid; D001323:Autoantibodies / Q000097:blood / Q000134:cerebrospinal fluid*; D002490:Central Nervous System / Q000503:physiopathology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000134:cerebrospinal fluid; D008875:Middle Aged; D009069:Movement Disorders / Q000209:etiology*; D012859:Sjogren's Syndrome / Q000134:cerebrospinal fluid / Q000276:immunology* / Q000473:pathology / Q000503:physiopathology
chemical_list: D000974:Antibodies, Antinuclear; D001323:Autoantibodies; D007074:Immunoglobulin G; C035356:SS-A antibodies; C035357:SS-B antibodies