Effects of dioxin on metabolism of estrogens in waste incinerator workers.
The authors measured the concentrations of serum dioxins and urinary estrogen metabolites in 57 male waste incinerator workers to determine whether dioxin influenced the metabolism of estrogens. Concentrations of serum dioxin levels and urinary estrogen metabolites, such as estrone, 17beta-estradiol, 2-hydroxyestrone, 2-methoxyestrone, 2-hydroxyestradiol, 2-methoxyestradiol, 4-hydroxyestrone, 4-hydroxyestradiol, 4-methoxyestradiol, 16-hydroxyestrone, and estriol from the workers were measured. An analysis of covariance showed that mean estriol concentrations, adjusted for confounding factors among 3 serum dioxin levels, indicated a progressive increase with increasing serum dioxin level: 1.30, 1.41, and 2.02 nmol/mol creatinine at < 30.3, 30.3-39.7, and > 39.7 pg toxicity equivalent quantity/g lipid, respectively (F = 3.56, p = .036). This study showed that dioxin acts to metabolize estrogens to 16-hydroxyestrogens rather than to 2- or 4-hydroxyestrogens.
Yoshida
Jin
J
Department of Environmental Health, Osaka Prefectural Institute of Public Health, Osaka, Japan. jnyosida@iph.pref.osaka.jp
Kumagai
Shinji
S
Tabuchi
Takeo
T
Kosaka
Hiroshi
H
Akasaka
Susumu
S
Oda
Hajime
H
D000328:Adult; D000395:Air Pollutants, Occupational / Q000097:blood / Q000633:toxicity*; D003577:Cytochrome P-450 Enzyme System / Q000187:drug effects; D004147:Dioxins / Q000097:blood / Q000633:toxicity*; D004967:Estrogens / Q000378:metabolism* / Q000652:urine; D006306:Health Surveys; D006801:Humans; D017745:Incineration; D008297:Male; D053858:Metabolic Networks and Pathways; D008875:Middle Aged; D016273:Occupational Exposure / Q000009:adverse effects*; D011795:Surveys and Questionnaires
D000395:Air Pollutants, Occupational; D004147:Dioxins; D004967:Estrogens; D003577:Cytochrome P-450 Enzyme System