title: Different antioxidant profiles in Italian centenarians: the Sardinian peculiarity.
abstract: In this study, 153 Italian centenarians from four different geographical areas, including Modena (northern Italy), Ancona (central Italy), Perugia (central Italy) and Sardinia island (AKEA Project) were enrolled. Plasma levels of vitamin C, uric acid, vitamin A and vitamin E as well as the activities of superoxide dismutase and glutathione peroxidase were measured. Subjects were compared to a younger control population of the same areas, divided into three age groups: <or=60; 61-80 and 81-99 years. The main result of this study is that, whereas in Italian population elevated levels of plasma vitamins A and E seem to be important for longevity, this do not apply to centenarians from Sardinia, in which probably other factors play a more important role.
authors.affiliation: Institute of Biochemistry and Molecular Biology I, Heinrich-Heine Universität Düsseldorf, Germany.
authors.forename: M C
authors.initials: MC
authors.lastname: Polidori
authors.forename: E
authors.initials: E
authors.lastname: Mariani
authors.forename: G
authors.initials: G
authors.lastname: Baggio
authors.forename: L
authors.initials: L
authors.lastname: Deiana
authors.forename: C
authors.initials: C
authors.lastname: Carru
authors.forename: G M
authors.initials: GM
authors.lastname: Pes
authors.forename: R
authors.initials: R
authors.lastname: Cecchetti
authors.forename: C
authors.initials: C
authors.lastname: Franceschi
authors.forename: U
authors.initials: U
authors.lastname: Senin
authors.forename: P
authors.initials: P
authors.lastname: Mecocci
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000097:blood* / Q000378:metabolism; D000975:Antioxidants / Q000032:analysis / Q000378:metabolism*; D001205:Ascorbic Acid / Q000097:blood; D005260:Female; D005979:Glutathione Peroxidase / Q000378:metabolism; D006801:Humans; D007558:Italy; D008136:Longevity; D008297:Male; D018384:Oxidative Stress; D013482:Superoxide Dismutase / Q000378:metabolism; D014527:Uric Acid / Q000097:blood; D014801:Vitamin A / Q000097:blood; D014810:Vitamin E / Q000097:blood; D014815:Vitamins / Q000097:blood* / Q000378:metabolism
chemical_list: D000975:Antioxidants; D014815:Vitamins; D014801:Vitamin A; D014810:Vitamin E; D014527:Uric Acid; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D001205:Ascorbic Acid