Characterization and activity of sonochemically-prepared BSA microspheres containing Taxol--an anticancer drug.
Proteinaceous microspheres of BSA (Bovine Serum Albumin) containing an anticancer drug, Taxol (paclitaxel) were fabricated using a sonochemical procedure and then assayed for chemical and biological activity. The sonochemical reaction did not compromise the drug, which became encapsulated in the BSA microspheres. The amount of the anticancer drug in the microspheres was determined by HPLC. Anticancer activity of the proteinaceous microspheres encapsulating the Taxol was tested on Mouse Multiple Myeloma cell line MPC-11. The influence of the Taxol microspheres on the cancer cells was different from pristine Taxol. It was found that Taxol in combination with the organic solvent causes the death of cancer cells.
Grinberg
Olga
O
Department of Chemistry and Kanbar Laboratory for Nanomaterials at the Bar-Ilan University, Center for Advanced Materials and Nanotechnology, Bar-Ilan University, Ramat-Gan, 52900, Israel.
Hayun
Michal
M
The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 52900, Israel.
Sredni
Benjamin
B
The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 52900, Israel.
Gedanken
Aharon
A
Department of Chemistry and Kanbar Laboratory for Nanomaterials at the Bar-Ilan University, Center for Advanced Materials and Nanotechnology, Bar-Ilan University, Ramat-Gan, 52900, Israel. Electronic address: gedanken@mail.biu.ac.il.
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D008863:Microspheres; D015394:Molecular Structure; D017239:Paclitaxel / Q000737:chemistry*; D012710:Serum Albumin, Bovine / Q000737:chemistry*; D013010:Sonication; D013499:Surface Properties; D013678:Technology, Pharmaceutical / Q000379:methods*
D000972:Antineoplastic Agents, Phytogenic; D012710:Serum Albumin, Bovine; D017239:Paclitaxel