title: [Impact of nutrition management in patients with head and neck cancers treated with irradiation: is the nutritional intervention useful?].
abstract: OBJECTIVE
  The head and neck tumors are most often associated with a precarious nutritional status. Radiotherapy increases the risk of denutrition because of its secondary effects on the secretory and sensorial mucous membranes. The purpose of our retrospectively study was to evaluate the interest of a precocious and regular nutritional therapy on the ability to maintain the nutritional status of the patient during the radiotherapy.
  
  
  METHODS
  The fifty-two patients included in the survey have been classified retrospectively in two different groups based on their observance to the nutritional therapy: group 1 "good observance", group 2 "bad observance".
  
  
  RESULTS
  The 31 patients of group 1 have lost an average of 1.9 kg by the end of the irradiation, whereas the 21 patients of group 2 have lost an average of 6.1 kg (p<0.001). The almost stability in weight of patients in group 1 was linked to a lower frequency of breaks in the radiotherapy (6 vs 33% p=0.03) and in a decrease in grade of inflammatory mucous membranes (10% of grade 3 in group 1 vs 52% in group 2, p=0.006). The quantity of calories ingested in form of nutritional supplements was greater in group 1 and consequently enabled patients to stabilized their weight (1200 calories in group 1 versus 850 calories in group 2, p<0.005).
  
  
  CONCLUSIONS
  The given nutritional advice and the prescription of adapted nutritional supplements consequently allowed limiting efficiently the weight lost during the irradiation and the grade of mucositis. The systematization of a precocious nutritional therapy for patients irradiated for head and neck tumors seems absolutely essential.
authors.affiliation: Service de diététique, institut Curie, 26, rue d'Ulm, 75005 Paris, France. valerie.garabige@curie.net
authors.forename: V
authors.initials: V
authors.lastname: Garabige
authors.forename: P
authors.initials: P
authors.lastname: Giraud
authors.forename: Y
authors.initials: Y
authors.lastname: De Rycke
authors.forename: A
authors.initials: A
authors.lastname: Girod
authors.forename: T
authors.initials: T
authors.lastname: Jouffroy
authors.forename: C
authors.initials: C
authors.lastname: Jaulerry
authors.forename: F
authors.initials: F
authors.lastname: Brunin
authors.forename: J
authors.initials: J
authors.lastname: Rodriguez
mesh_terms: D001835:Body Weight; D002149:Energy Intake; D005260:Female; D006258:Head and Neck Neoplasms / Q000532:radiotherapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D052016:Mucositis / Q000517:prevention & control; D044623:Nutrition Therapy; D011446:Prospective Studies