title: Primary myelofibrosis (PMF), post polycythemia vera myelofibrosis (post-PV MF), post essential thrombocythemia myelofibrosis (post-ET MF), blast phase PMF (PMF-BP): Consensus on terminology by the international working group for myelofibrosis research and treatment (IWG-MRT).
abstract: The International Working Group for Myelofibrosis Research and Treatment (IWG-MRT) is comprised of hematologists, hematopathologists, and laboratory scientists and its main goal is to provide a forum for scientific exchange and collaboration. During its first general meeting in April 2006, the IWG-MRT established uniform treatment response criteria for chronic idiopathic myelofibrosis (CIMF); also known as agnogenic myeloid metaplasia (AMM), myelofibrosis with myeloid metaplasia (MMM), and many other names in the hematologic literature. This document summarizes the proceedings from the second meeting of the IWG-MRT, in November 2006, where the group discussed and agreed to standardize the nomenclature referring to CIMF: (i) the term primary myelofibrosis (PMF) was chosen over several other designations including CIMF, AMM, and MMM, (ii) myelofibrosis that develops in the setting of either polycythemia vera (PV) or essential thrombocythemia (ET) will be referred to as post-PV MF and post-ET MF, respectively, and (iii) "leukemic" transformation will be recognized as blast phase disease (PMF-BP, post-PV/ET MF in blast phase).
authors.affiliation: Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
authors.forename: Ruben A
authors.initials: RA
authors.lastname: Mesa
authors.forename: Srdan
authors.initials: S
authors.lastname: Verstovsek
authors.forename: Francisco
authors.initials: F
authors.lastname: Cervantes
authors.forename: Giovanni
authors.initials: G
authors.lastname: Barosi
authors.forename: John T
authors.initials: JT
authors.lastname: Reilly
authors.forename: Brigitte
authors.initials: B
authors.lastname: Dupriez
authors.forename: Ross
authors.initials: R
authors.lastname: Levine
authors.forename: Marie-Caroline
authors.initials: MC
authors.lastname: Le Bousse-Kerdiles
authors.forename: Martha
authors.initials: M
authors.lastname: Wadleigh
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Campbell
authors.forename: Richard T
authors.initials: RT
authors.lastname: Silver
authors.forename: Alessandro M
authors.initials: AM
authors.lastname: Vannucchi
authors.forename: H Joachim
authors.initials: HJ
authors.lastname: Deeg
authors.forename: Heinz
authors.initials: H
authors.lastname: Gisslinger
authors.forename: Deborah
authors.initials: D
authors.lastname: Thomas
authors.forename: Olatoyosi
authors.initials: O
authors.lastname: Odenike
authors.forename: Lawrence A
authors.initials: LA
authors.lastname: Solberg
authors.forename: Jason
authors.initials: J
authors.lastname: Gotlib
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Hexner
authors.forename: Stephen D
authors.initials: SD
authors.lastname: Nimer
authors.forename: Hagop
authors.initials: H
authors.lastname: Kantarjian
authors.forename: Attilio
authors.initials: A
authors.lastname: Orazi
authors.forename: James W
authors.initials: JW
authors.lastname: Vardiman
authors.forename: Juergen
authors.initials: J
authors.lastname: Thiele
authors.forename: Ayalew
authors.initials: A
authors.lastname: Tefferi
mesh_terms: D001752:Blast Crisis / Q000145:classification / Q000473:pathology; D002471:Cell Transformation, Neoplastic / Q000145:classification / Q000473:pathology; D002908:Chronic Disease; D006801:Humans; D011087:Polycythemia Vera / Q000145:classification / Q000473:pathology; D055728:Primary Myelofibrosis / Q000145:classification / Q000473:pathology; D009626:Terminology as Topic; D013920:Thrombocythemia, Essential / Q000145:classification / Q000473:pathology