title: Carrier rate of Factor XI deficiency in stunted Japanese black cattle.
abstract: Blood examinations and genotyping of Factor XI (F11) were performed in growth retardation Japanese Black cattle and their dams. Genotyping of F11 revealed that the recessive homozygous and heterozygous genotype frequencies were 5.2% and 50.0% in the Claudin-16 (CL-16) deficiency group (n=58), 0% and 14.2% in the renal dysplasia group (n=7), 0% and 26.1% in the non-CL-16 deficiency nephritis group (n=23), 8.9% and 46.7% in the hypogenesis syndrome group (n=45), 6.2% and 25.0% in the neonatal weak calf syndrome group (n=32), 9.1% and 38.6% in the respective dams group (n=44), 0% and 23.1% in the normal cattle group (n=13), and 5.9% and 38.2% in total (n=222), respectively. These results showed that the carrier rate of F11 deficiency was high in Japanese Black cattle, and that the CL-16 deficiency, hypogenesis syndrome, neonatal weak calf syndrome, and dams groups had a large amount of recessive homozygous genotype than the other groups. No abnormal bleeding was observed clinically in the present study, and 4 of the recessive homozygous dams showed normal growth and parturition.
authors.affiliation: School of Veterinary Medicine and Animal Sciences, Kitasato University, Towada, Aomori, Japan.
authors.forename: Daisaku
authors.initials: D
authors.lastname: Watanabe
authors.forename: Takashi
authors.initials: T
authors.lastname: Hirano
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Sugimoto
authors.forename: Yoshimi
authors.initials: Y
authors.lastname: Ogata
authors.forename: Shogo
authors.initials: S
authors.lastname: Abe
authors.forename: Takaaki
authors.initials: T
authors.lastname: Ando
authors.forename: Hiromichi
authors.initials: H
authors.lastname: Ohtsuka
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Kunieda
authors.forename: Seiichi
authors.initials: S
authors.lastname: Kawamura
mesh_terms: D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000453:epidemiology* / Q000235:genetics*; D005172:Factor XI / Q000235:genetics; D005173:Factor XI Deficiency / Q000453:epidemiology / Q000235:genetics / Q000662:veterinary*; D005260:Female; D005838:Genotype; D006579:Heterozygote; D007564:Japan / Q000453:epidemiology; D008297:Male
chemical_list: D005172:Factor XI