title: [Sepsis caused by Fusobacterium necrophorum (Lemierre syndrome): a rare complication of acute pharyngotonsilitis].
abstract: Lemierre syndrome is defined as an acute pharyngotonsillar infection that has spread into the lateral pharyngeal space causing thrombophlebitis of the internal jugular vein with consecutive metastatic emboli. The syndrome is most often caused by Fusobacterium (F.) necrophorum and usually involves young, previously healthy people. We present a healthy 20-year-old man who suddenly developed with high fever and sore throat followed by dyspnea, tachypnea and cough on the third day of illness. His condition worsened despite outpatient intramuscular penicillin therapy (1600 000 IU/day). He was admitted to Dr. Fran Mihaljević University Hospital for Infectious Diseases, Zagreb, on the sixth day of his illness with clinical signs of sepsis. Chest radiograph showed bilateral multiple infiltrates. F. necrophorum was isolated from blood culture. Swelling of the neck was also observed on the fourteenth day of illness, however, thrombophlebitis of the jugular vein was not diagnosed on ultrasound examination. The patient was treated with clindamycin for five weeks and recovered completely.
authors.affiliation: Klinika za infektivne bolesti Dr. Fran Mihaljević, Zagreb, Hrvatska.
authors.forename: Marta
authors.initials: M
authors.lastname: Perović
authors.forename: Tomislav
authors.initials: T
authors.lastname: Maretić
authors.forename: Josip
authors.initials: J
authors.lastname: Begovac
mesh_terms: D000208:Acute Disease; D000328:Adult; D005674:Fusobacterium Infections / Q000150:complications*; D005675:Fusobacterium necrophorum; D006801:Humans; D007601:Jugular Veins; D008297:Male; D010612:Pharyngitis / Q000150:complications* / Q000382:microbiology; D018805:Sepsis / Q000382:microbiology*; D013924:Thrombophlebitis / Q000209:etiology*; D014069:Tonsillitis / Q000150:complications* / Q000382:microbiology