title: Perianal Paget's disease.
abstract: BACKGROUND
  Perianal Paget's disease is an uncommon intraepithelial neoplasm that involves areas affluent with apocrine glands, most frequently in the female external genitalia, but may also affect the perianal region.
  
  
  OBJECTIVE
  We present the pathologic and clinical management of a case of Paget's disease involving the perianal region, in which diagnosis was delayed for 8 years.
  
  
  CONCLUSIONS
  The importance of a high index of suspicion for early diagnosis is emphasized, which should be followed by aggressive surgical treatment with wide excision and local reconstruction.
authors.affiliation: Department of Plastic and Reconstructive Surgery, Sheba Medical Center, Tel Aviv, Israel.
authors.forename: Zion
authors.initials: Z
authors.lastname: Zibly
authors.forename: Josefh
authors.initials: J
authors.lastname: Haik
authors.forename: Marat
authors.initials: M
authors.lastname: Khaikin
authors.forename: Iris
authors.initials: I
authors.lastname: Barshack
authors.forename: Oded
authors.initials: O
authors.lastname: Zmora
mesh_terms: D001005:Anus Neoplasms / Q000175:diagnosis* / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D010145:Paget Disease, Extramammary / Q000175:diagnosis* / Q000601:surgery; D016038:Skin Transplantation