Genetics and expression of the carbapenem-hydrolyzing oxacillinase gene blaOXA-23 in Acinetobacter baumannii.
The genetic structures surrounding the plasmid-carried blaOXA-23 oxacillinase gene, encoding resistance to carbapenems, were studied in Acinetobacter baumannii. ISAba1 and the novel element ISAba4 were detected upstream of the blaOXA-23 gene, providing promoter sequences for its expression. These insertion elements were likely involved in transposition processes at the origin of acquisition of this beta-lactamase gene.
Corvec
Stéphane
S
Service de Bactériologie-Virologie, Hôpital de Bicêtre, 78 rue du Général Leclerc, 94275 Le Kremlin-Bicêtre, France.
Poirel
Laurent
L
Naas
Thierry
T
Drugeon
Henri
H
Nordmann
Patrice
P
D040981:Acinetobacter baumannii / Q000201:enzymology / Q000235:genetics*; D015780:Carbapenems / Q000378:metabolism; D004251:DNA Transposable Elements / Q000235:genetics / Q000502:physiology*; D015870:Gene Expression; D008969:Molecular Sequence Data; D001618:beta-Lactamases / Q000235:genetics* / Q000378:metabolism*
D015780:Carbapenems; D004251:DNA Transposable Elements; C466679:beta-lactamase OXA-23; D001618:beta-Lactamases; C108449:oxacillinase