title: Effects of dioxin on metabolism of estrogens in waste incinerator workers.
abstract: The authors measured the concentrations of serum dioxins and urinary estrogen metabolites in 57 male waste incinerator workers to determine whether dioxin influenced the metabolism of estrogens. Concentrations of serum dioxin levels and urinary estrogen metabolites, such as estrone, 17beta-estradiol, 2-hydroxyestrone, 2-methoxyestrone, 2-hydroxyestradiol, 2-methoxyestradiol, 4-hydroxyestrone, 4-hydroxyestradiol, 4-methoxyestradiol, 16-hydroxyestrone, and estriol from the workers were measured. An analysis of covariance showed that mean estriol concentrations, adjusted for confounding factors among 3 serum dioxin levels, indicated a progressive increase with increasing serum dioxin level: 1.30, 1.41, and 2.02 nmol/mol creatinine at < 30.3, 30.3-39.7, and > 39.7 pg toxicity equivalent quantity/g lipid, respectively (F = 3.56, p = .036). This study showed that dioxin acts to metabolize estrogens to 16-hydroxyestrogens rather than to 2- or 4-hydroxyestrogens.
authors.affiliation: Department of Environmental Health, Osaka Prefectural Institute of Public Health, Osaka, Japan. jnyosida@iph.pref.osaka.jp
authors.forename: Jin
authors.initials: J
authors.lastname: Yoshida
authors.forename: Shinji
authors.initials: S
authors.lastname: Kumagai
authors.forename: Takeo
authors.initials: T
authors.lastname: Tabuchi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kosaka
authors.forename: Susumu
authors.initials: S
authors.lastname: Akasaka
authors.forename: Hajime
authors.initials: H
authors.lastname: Oda
mesh_terms: D000328:Adult; D000395:Air Pollutants, Occupational / Q000097:blood / Q000633:toxicity*; D003577:Cytochrome P-450 Enzyme System / Q000187:drug effects; D004147:Dioxins / Q000097:blood / Q000633:toxicity*; D004967:Estrogens / Q000378:metabolism* / Q000652:urine; D006306:Health Surveys; D006801:Humans; D017745:Incineration; D008297:Male; D053858:Metabolic Networks and Pathways; D008875:Middle Aged; D016273:Occupational Exposure / Q000009:adverse effects*; D011795:Surveys and Questionnaires
chemical_list: D000395:Air Pollutants, Occupational; D004147:Dioxins; D004967:Estrogens; D003577:Cytochrome P-450 Enzyme System