title: Selective defect in plasmacyoid dendritic cell function in a patient with AIDS-associated atypical genital herpes simplex vegetans treated with imiquimod.
abstract: We report a case of acquired immunodeficiency syndrome (AIDS)-associated, acyclovir-refractory genital herpes infection treated with topical imidazoquinoline therapy. The patient's plasmacytoid dendritic cells made a robust interferon- alpha response following in vitro stimulation with imidazoquinoline but not with herpes simplex virus. We hypothesize that disease resulting from defective herpes simplex virus-stimulated interferon- alpha may be overcome by stimulating intact alternative pathways.
authors.affiliation: The Miami Veterans Administration Medical Center, Miami, FL, USA.
authors.forename: Lillian
authors.initials: L
authors.lastname: Abbo
authors.forename: Vladimir
authors.initials: V
authors.lastname: Vincek
authors.forename: Gordon
authors.initials: G
authors.lastname: Dickinson
authors.forename: Niraj
authors.initials: N
authors.lastname: Shrestha
authors.forename: Susanne
authors.initials: S
authors.lastname: Doblecki
authors.forename: Patrick A J
authors.initials: PA
authors.lastname: Haslett
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy / Q000821:virology; D000212:Acyclovir / Q000494:pharmacology; D000328:Adult; D000634:Aminoquinolines / Q000627:therapeutic use*; D000998:Antiviral Agents / Q000494:pharmacology; D003713:Dendritic Cells / Q000473:pathology*; D015658:HIV Infections / Q000150:complications / Q000276:immunology*; D015497:HIV-1 / Q000276:immunology; D006558:Herpes Genitalis / Q000188:drug therapy*; D018258:Herpesvirus 2, Human / Q000187:drug effects; D006801:Humans; D000077271:Imiquimod; D007369:Interferon Inducers / Q000627:therapeutic use*; D008297:Male
chemical_list: D000634:Aminoquinolines; D000998:Antiviral Agents; D007369:Interferon Inducers; D000077271:Imiquimod; D000212:Acyclovir