Pneumolysin, PspA, and PspC contribute to pneumococcal evasion of early innate immune responses during bacteremia in mice.
The pneumococcal virulence factors include capsule, PspA, PspC, and Ply. Cytometric analysis demonstrated that the greatest levels of C3 deposition were on a Deltaply PspA(-) PspC(-) mutant. Also, Ply, PspA, and PspC expression resulted in C3 degradation in vitro and in vivo. Finally, blood clearance assays demonstrated that there was enhanced clearance of Deltaply PspA(-) PspC(-) pneumococci compared to the clearance of nonencapsulated pneumococci.
Quin
Lisa R
LR
Department of Microbiology, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA.
Moore
Quincy C
QC
McDaniel
Larry S
LS
D000818:Animals; D000954:Antigens, Surface / Q000235:genetics / Q000502:physiology*; D016470:Bacteremia / Q000276:immunology; D001426:Bacterial Proteins / Q000235:genetics / Q000502:physiology*; D001769:Blood / Q000382:microbiology; D015169:Colony Count, Microbial; D003176:Complement C3 / Q000378:metabolism; D051379:Mice; D011008:Pneumococcal Infections / Q000276:immunology*; D013296:Streptococcus pneumoniae / Q000276:immunology* / Q000472:pathogenicity*; D013301:Streptolysins / Q000235:genetics / Q000502:physiology*; D037521:Virulence Factors / Q000235:genetics / Q000502:physiology*
D000954:Antigens, Surface; D001426:Bacterial Proteins; D003176:Complement C3; D013301:Streptolysins; D037521:Virulence Factors; C032290:plY protein, Streptococcus pneumoniae; C051592:pneumococcal surface protein A