[Role of neuropeptide galanin in formation of the typical behavioural characteristics].
Blockade of central galanin receptors through intranasal treatment with specific antagonis M-35 changes the behavioral reactions to novel conditions: the animals treated with M-35 show decreased exploratory activity and increased anxiety level in open field test. The level of pre-progalanin mRNA expression in brain structures was investigated in Wistar rats with opposite strategies of behaviors in open field test. A higher level of pre-progalanin mRNA in anterior hypothalamus of "active" rats was revealed as compared with "passive" rats. The rats treated with galanin receptor antagonist showed a significant rise of serum corticosteron level immediately after forced swimming, while the control rats (without M-35) had only slight corticosterone increase under the sam conditions. The data obtained suggest involvement of brain galanin in formation of individual beha vior and indicate important role of galanin in coping with the stress.
Liudyno
V I
VI
Abdurasulova
I N
IN
Klimenko
V M
VM
D000281:Administration, Intranasal; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology*; D001920:Bradykinin / Q000031:analogs & derivatives / Q000494:pharmacology; D001921:Brain / Q000378:metabolism; D003345:Corticosterone / Q000097:blood; D019004:Galanin / Q000378:metabolism* / Q000494:pharmacology; D008297:Male; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology; D010446:Peptide Fragments / Q000494:pharmacology; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D044088:Receptors, Galanin / Q000037:antagonists & inhibitors; D013315:Stress, Psychological / Q000378:metabolism
D010446:Peptide Fragments; D012333:RNA, Messenger; D044088:Receptors, Galanin; C074069:galanin-(1-13)-bradykinin-(2-9)-amide; D019004:Galanin; D001920:Bradykinin; D003345:Corticosterone