Effect of dietary oils on lymphocyte immunological activity in psychologically stressed mice.
Psychological stress has been shown to modulate immune functions. In this study, we investigated the effect of dietary oils (olive oil, soybean oil, and fish oil) on the social isolation stress-induced modulation of lymphocyte immunological activities in mice. In olive oil-fed, but not soybean oil- or fish oil-fed, mice, a 2-week isolation stress decreased the lymphocyte proliferative response, reduced the interferon-gamma and interleukin (IL)-10 secretions and increased the IL-4 secretion by lymphocytes. The isolation stress reduced the arachidonic acid content of lymphocytes markedly, moderately, and not at all in the olive oil-, soybean oil-, and fish oil-fed mice, respectively. In the olive oil-fed, but not soybean oil- or fish oil-fed, mice, the isolation stress up-regulated the expression level of mRNA for splenic heat-shock protein 70 and increased lymphocyte sensitivity to the antiproliferative effect of corticosterone. This is the first demonstration that effect of psychological stress on lymphocyte immunological activities can vary depending upon the dietary fatty acid composition.
Oarada
Motoko
M
Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University, Japan. motoko.o@faculty.chiba-u.jp
Gonoi
Tohru
T
Tsuzuki
Tsuyoshi
T
Igarashi
Miki
M
Hirasaka
Katsuya
K
Nikawa
Takeshi
T
Onishi
Yuko
Y
Toyotome
Takahito
T
Kamei
Katsuhiko
K
Miyazawa
Teruo
T
Nakagawa
Kiyotaka
K
Kashima
Minoru
M
Kurita
Nobuyuki
N
D000818:Animals; D001070:Appetitive Behavior; D001835:Body Weight / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D003345:Corticosterone / Q000097:blood / Q000494:pharmacology; D016207:Cytokines / Q000378:metabolism; D004042:Dietary Fats, Unsaturated / Q000378:metabolism / Q000494:pharmacology*; D005260:Female; D015870:Gene Expression; D008214:Lymphocytes / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism*; D051379:Mice; D008807:Mice, Inbred BALB C; D009929:Organ Size / Q000187:drug effects; D012333:RNA, Messenger / Q000235:genetics; D013154:Spleen / Q000187:drug effects / Q000378:metabolism; D013312:Stress, Physiological / Q000276:immunology* / Q000378:metabolism* / Q000523:psychology
D016207:Cytokines; D004042:Dietary Fats, Unsaturated; D012333:RNA, Messenger; D003345:Corticosterone