title: Spin system assignment of homo-o-phenylene ethynylene oligomers.
abstract: We previously reported the synthesis and solution characterization of short o-phenylene ethynylene (oPE) foldamers. Proton correlation techniques are not adequate for NMR assignment in these compounds as the ethynylene linkers interrupt proton connectivity. In order to facilitate structural characterization and more fully harness the power of NMR, it is necessary to know the sequence of spin systems along the molecular backbone. For example, spin system assignment is required to unambiguously assign NOE correlations for structural determination of folded forms in solution. Therefore, we developed a method to assign the aromatic spin systems in these compounds using HMBC experiments. This has been performed for tetrameric (Es4), pentameric (Es5), and hexameric (Es6) oligomers and is expected to prove useful for this class of foldamers in general. The proton assignments obtained by this technique have been useful toward confirming the previous hypotheses of helical folding in oPE systems.
authors.affiliation: Polymer Science & Engineering Department, University of Massachusetts, Amherst, Massachusetts 01003, USA.
authors.forename: Morris M
authors.initials: MM
authors.lastname: Slutsky
authors.forename: Ticora V
authors.initials: TV
authors.lastname: Jones
authors.forename: Gregory N
authors.initials: GN
authors.lastname: Tew
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D012680:Sensitivity and Specificity; D013237:Stereoisomerism
chemical_list: D000480:Alkynes; C508010:o-phenylene ethynylene