[Fourier transform infrared spectroscopy study on normal and malignant tissues of cervix].
Fourier transform infrared spectroscopy (FTIR) was used to investigate 35 cervical tissues , including 17 squamous cell carcinoma of cervical samples, and 5 adenocarcinoma of cervical samples, 13 normal cervical samples. The results show that there are 18 spectral bands with highly appearance percentage(>80%) in these three types of tissues, and these spectral bands may be the characteristic infrared spectra bands for cervical tissues; Some of relative absorbance ratios are statistically significant (p < 0.05) among these three types of tissues. These differences of relative absorbance ratios are mainly centered at 1080, 1238, 1314, 1339, 1397, 1454, 1541, 1647, 2854, 2873, 2926, and 2958 cm(-1). The present results indicate that FTIR can be used to distinguish these three types of tissues. The utilization of FTIR spectra in cervical tissues is expected to be a hopeful method in cervical cancer screening and clinical diagnosis in the future.
Li
Wei-xiu
WX
Medical College of Xi'an Jiaotong University, Xi'an 710061, China.
Zheng
Quan-qing
QQ
Wang
Ping
P
Li
Yan-qin
YQ
Chen
Guang-hua
GH
D000328:Adult; D000368:Aged; D002584:Cervix Uteri / Q000473:pathology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D011247:Pregnancy; D017550:Spectroscopy, Fourier Transform Infrared / Q000379:methods; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis / Q000473:pathology