title: Acute neurological deficits caused by cefipime: a case report and review of literature.
abstract: Cefepime (Maxipime) is a fourth-generation cephalosporin commonly used to treat a variety of infections. Its controversial side effect profile is not well appreciated by first-line practitioners. We report a case of urinary tract infection treated with cefepime in a 91-year-old woman. The acute onset of conscuous disturbance was noted on the 9th day of cefepime treatment. Computed tomogram and magnetic resonance image of the brain showed no specific findings. The neurological symptoms and signs such us conscious disturbance, ocular bobbing, asterexis disappeared after discontinuation of cefepime. We suggest that physicians should cefepime as a possible cause of reversible neurological deficits.
authors.affiliation: Department of Neurology, Mackay Memorial Hospital, Taipei, Taiwan. googlejoseph@yahoo.com.tw
authors.forename: Chih-Ming
authors.initials: CM
authors.lastname: Lin
authors.forename: Yi-Min
authors.initials: YM
authors.lastname: Chen
authors.forename: Helen L
authors.initials: HL
authors.lastname: Po
authors.forename: I-Hung
authors.initials: IH
authors.lastname: Hseuh
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D000077723:Cefepime; D002511:Cephalosporins / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D020521:Stroke / Q000139:chemically induced*; D014552:Urinary Tract Infections / Q000188:drug therapy
chemical_list: D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D000077723:Cefepime