title: Survival rates for stage II colon cancer patients treated with or without chemotherapy in a population-based setting.
abstract: OBJECTIVE
  There is considerable uncertainty as to whether adjuvant 5-fluorouracil-based chemotherapy provides survival benefit for colon cancer patients with stage II disease. Consequently, the current rates of chemotherapy use for this disease are low despite 5-year survival rates of only 70-80%. The aim of the present study is to compare the survival rate of stage II colon cancer patients treated by surgery alone with that of patients also treated by chemotherapy.
  
  
  METHODS
  A population-based observational study was conducted on the survival of stage II colon cancer patients (n = 812) diagnosed in Western Australia from 1993 to 2003. The study was restricted to patients aged < or =75 years, of whom 18% (n = 142) were treated with chemotherapy. Only 0.9% of patients older than 75 years received chemotherapy.
  
  
  RESULTS
  Patients who received chemotherapy were significantly younger (mean age 6 years) than those treated by surgery alone (65 years, P < 0.001), and their tumors were more often positive for vascular invasion (P = 0.007). Multivariate analysis that included all prognostic factors revealed adjuvant chemotherapy was associated with improved survival (HR = 0.62, 95% CI [0.39-0.98], P = 0.043), with women gaining more benefit (HR = 0.48, 95% CI [0.20-1.22], P = 0.09) than men (HR = 0.94, 95% CI [0.54-1.64], P = 0.8).
  
  
  CONCLUSIONS
  In view of the apparent survival benefit from chemotherapy for stage II colon cancer, the present study raises concerns about the current low rates of adjuvant treatment for this disease in the community, particularly for female patients.
authors.affiliation: School of Surgery and Pathology M507, University of Western Australia, Nedlands, Australia.
authors.forename: Melinda
authors.initials: M
authors.lastname: Morris
authors.forename: Cameron
authors.initials: C
authors.lastname: Platell
authors.forename: Kieran
authors.initials: K
authors.lastname: McCaul
authors.forename: Michael
authors.initials: M
authors.lastname: Millward
authors.forename: Guy
authors.initials: G
authors.lastname: van Hazel
authors.forename: Evan
authors.initials: E
authors.lastname: Bayliss
authors.forename: James
authors.initials: J
authors.lastname: Trotter
authors.forename: David
authors.initials: D
authors.lastname: Ransom
authors.forename: Barry
authors.initials: B
authors.lastname: Iacopetta
mesh_terms: D000328:Adult; D017677:Age Distribution; D000367:Age Factors; D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D003110:Colonic Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D013505:Digestive System Surgical Procedures; D018572:Disease-Free Survival; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use*; D005500:Follow-Up Studies; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D011159:Population Surveillance; D016016:Proportional Hazards Models; D012737:Sex Factors; D013997:Time Factors; D016896:Treatment Outcome; D014904:Western Australia
chemical_list: D000964:Antimetabolites, Antineoplastic; D005472:Fluorouracil