title: Topical use of tranexamic acid to control perioperative local bleeding in gynaecology patients with clotting disorders: two cases.
abstract: Operating on patients with abnormal coagulation is a challenge frequently faced by surgeons. Achieving haemostasis perioperatively can involve bleeding points that would not ordinarily present a problem with intact clotting function. Here we present two women with localised wound bleeding following a gynaecological surgery in the presence of a clotting disorder. Haemostasis was successfully achieved with tropical use of tranexamic acid. These two cases illustrate a novel use for this antifibrinolytic agent. We suggest that there is a role for topical use of tranexamic acid in perioperative haemostasis in patients with clotting disorders.
authors.affiliation: Royal Free Hospital NHS Trust, Department of Obstetrics and Gynaecology, London, UK.
authors.forename: I
authors.initials: I
authors.lastname: Sarris
authors.forename: A
authors.initials: A
authors.lastname: Arafa
authors.forename: L
authors.initials: L
authors.lastname: Konaris
authors.forename: R A
authors.initials: RA
authors.lastname: Kadir
mesh_terms: D000284:Administration, Oral; D000287:Administration, Topical; D000368:Aged; D000933:Antifibrinolytic Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D001778:Blood Coagulation Disorders / Q000150:complications* / Q000601:surgery; D016063:Blood Loss, Surgical / Q000517:prevention & control*; D005260:Female; D002836:Hemophilia B / Q000150:complications / Q000601:surgery; D006801:Humans; D007044:Hysterectomy; D007889:Leiomyoma / Q000150:complications / Q000601:surgery; D008875:Middle Aged; D013922:Thrombocytosis / Q000150:complications / Q000601:surgery; D014148:Tranexamic Acid / Q000008:administration & dosage* / Q000627:therapeutic use; D014596:Uterine Prolapse / Q000150:complications / Q000601:surgery; D014621:Vagina / Q000601:surgery
chemical_list: D000933:Antifibrinolytic Agents; D014148:Tranexamic Acid