Relationship among TNF-alpha, sICAM-1, and selenium in presurgical patients with abdominal aortic aneurysms.
The purpose of our study was to estimate the utility of tumor necrosis factor (TNF), soluble intercellular adhesion molecule-1 (sICAM-1), and selenium (Se) measurements as subsidiary parameters for the diagnosis and differentiation of large aortic abdominal aneurysms (AAAs). The TNF and sICAM-1 levels in AAAs were significantly higher than in the controls. On the contrary, the Se level in AAAs was slightly lower; however, the difference was not significant. sICAM-1 did not correlate with TNF or Se as well as with any physical parameter. TNF was related to body mass index (r = 0.375). A negative correlation was found for Se and the aneurysm's diameter (r = -0.382), especially for the height-adjusted diameter (r = -0.418). The results of the present study do not allow one to count TNF and sICAM-1 as markers of AAA advancement. It was shown for the first time that the level of serum Se is low in ruptured aneurysms, but not in the unruptured AAAs.
Witkowska
Anna M
AM
Department of Food Commodities Science and Technology, Medical University, Bialystok, Poland.
Borawska
Maria H
MH
Gacko
Marek
M
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017544:Aortic Aneurysm, Abdominal / Q000097:blood* / Q000601:surgery; D005260:Female; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011300:Preoperative Care; D012643:Selenium / Q000097:blood*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
D014409:Tumor Necrosis Factor-alpha; D018799:Intercellular Adhesion Molecule-1; D012643:Selenium