title: Membrane-regulated stress response: a theoretical and practical approach.
abstract: Anumber of observations have lent support to a model in which thermal stress is transduced into a signal at the level of the cellular membranes. Our alternative, but not exclusive, approach is based on the concept that the initial stress-sensing events are associated with the physical state and lipid composition of cellular membranes, i.e., the subtle alteration(s) of membrane fluidity, phase state, and/or microheterogeneity may operate as a cellular thermometer. In fact, various pathological states and aging are associated with typical "membrane defects" and simultaneous dysregulation of heat shock protein synthesis. The discovery of nonproteotoxic membrane-lipid interacting compounds, capable of modulating membrane microdomains engaged in primary stress sensing may be of paramount importance for the design of new drugs with the ability to induce or attenuate the level of particular heat shock proteins.
authors.affiliation: Institute of Biochemistry, Biological Research Center of the Hungarian Academy of Sciences, H-6726, Szeged, Temesvári Krt. 62, Hungary. Vigh@brc.hu
authors.forename: László
authors.initials: L
authors.lastname: Vígh
authors.forename: Zsolt
authors.initials: Z
authors.lastname: Török
authors.forename: Gábor
authors.initials: G
authors.lastname: Balogh
authors.forename: Attila
authors.initials: A
authors.lastname: Glatz
authors.forename: Stefano
authors.initials: S
authors.lastname: Piotto
authors.forename: Ibolya
authors.initials: I
authors.lastname: Horváth
mesh_terms: D000818:Animals; D002462:Cell Membrane / Q000378:metabolism* / Q000473:pathology*; D019295:Computational Biology; D019143:Evolution, Molecular; D006801:Humans; D050356:Lipid Metabolism; D008954:Models, Biological; D015398:Signal Transduction