title: Relationship between hemostatic factors and the platelet index in patients with ischemic heart disease.
abstract: To understand the heterogeneity of platelets, we investigated the correlation between hemostatic factors and the platelet index [platelet count, mean platelet volume (MPV), platelet-large cell ratio (P-LCR) and platelet distribution width (PDW)] in patients with ischemic heart disease (IHD). Ninety-seven patients with IHD and 120 aged controls (AC) were enrolled in the study. D-dimer, thrombin-antithrombin III complex (TAT), von Willebrand factor antigen (VWF:Ag) and platelet indexes were measured in the peripheral venous blood. The D-dimer and TAT levels in the patients were significantly elevated compared to the AC. VWF:Ag was also elevated, but not significantly so. However, no differences were observed in the platelet index between the patients and the AC. In the patients, the level of VWF:Ag was significantly inversely correlated with the platelet count, but such correlations were not observed in the D-dimer and TAT. TAT was significantly positively correlated with MPV, P-LCR and PDW. VWF:Ag was also correlated, though not significantly, with MPV, P-LCR and PDW. The D-dimer was not correlated with the platelet index. In the AC, the platelet count was inversely correlated with VWF:Ag, but not significantly so. VWF:Ag showed significant positive correlations with MPV, P-LCR and PDW. However, the D-dimer and TAT were not correlated with the platelet index in AC. These findings suggest that VWF:Ag and TAT seem to be profoundly related to platelet volume.
authors.affiliation: Department of Hematology, National Hospital Organization Kure Medical Center, Kure, Hiroshima, Japan.
authors.forename: Akihiro
authors.initials: A
authors.lastname: Ihara
authors.forename: Toshiharu
authors.initials: T
authors.lastname: Kawamoto
authors.forename: Kengo
authors.initials: K
authors.lastname: Matsumoto
authors.forename: Saburou
authors.initials: S
authors.lastname: Shouno
authors.forename: Tadao
authors.initials: T
authors.lastname: Morimoto
authors.forename: Yasuharu
authors.initials: Y
authors.lastname: Noma
mesh_terms: D000368:Aged; D000990:Antithrombin III; D015415:Biomarkers / Q000097:blood; D001792:Blood Platelets / Q000473:pathology*; D016022:Case-Control Studies; D048430:Cell Shape; D048429:Cell Size; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis; D006487:Hemostasis; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000097:blood*; D010447:Peptide Hydrolases / Q000097:blood; D010976:Platelet Count; D014841:von Willebrand Factor / Q000032:analysis
chemical_list: D015415:Biomarkers; D005338:Fibrin Fibrinogen Degradation Products; C046193:antithrombin III-protease complex; C036309:fibrin fragment D; D014841:von Willebrand Factor; D000990:Antithrombin III; D010447:Peptide Hydrolases