title: Nikolai N. Anichkov and his theory of atherosclerosis.
abstract: Nikolai N. Anichkov (1885-1964) first demonstrated the role of cholesterol in the development of atherosclerosis. His classic experiments in 1913 paved the way to our current understanding of the role of cholesterol in cardiovascular disease. Anichkov's research is often cited among the greatest discoveries of the 20th century; however, little is known about Anichkov and his team. Herein, we give a detailed historical account of Anichkov's work, his personality, his research team, and their pioneering effort.
authors.affiliation: Division of Cardiovascular Surgery, Hospital for Sick Children, University of Toronto, Toronto, Canada. igorkonst@hotmail.com
authors.forename: Igor E
authors.initials: IE
authors.lastname: Konstantinov
authors.forename: Nicolai
authors.initials: N
authors.lastname: Mejevoi
authors.forename: Nikolai M
authors.initials: NM
authors.lastname: Anichkov
mesh_terms: D050197:Atherosclerosis / Q000209:etiology / Q000266:history / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D002784:Cholesterol / Q000266:history / Q000378:metabolism; D049672:History, 19th Century; D049673:History, 20th Century; D006801:Humans
chemical_list: D002784:Cholesterol