title: [Contribution and selected risks of blood transfusion].
abstract: OBJECTIVE
  Overview of recent knowledge about risks and benefits of blood transfusion.
  
  
  METHODS
  Review article.
  
  
  METHODS
  Department of Anaesthesiology and Intensive Care, University Hospital, Ostrava.
  
  
  METHODS
  Summary of previously published data.
  
  
  CONCLUSIONS
  Transfusion of blood and blood products remains controversial in clinical practice. Neither indication and timing nor benefit of this procedure is clearly determined. Previously often reported complications as blood-group incompatibility and infection are less frequent now, and new transfusion's side effects as TRIM (transfusion-related immunomodulation) and TRALI (transfusion-related lung injury) are reported with growing evidence. This risk (often underestimated in the past) is discussed in the article, and compared with blood transfusion benefits. Either restrictive or more open approach to blood transfusion are supported as well as criticised by different groups of clinicians and "good clinical practice" definition remains open for the future.
authors.affiliation: Department of Anaesthesiology and Intensive Care, University Hospital, Ostrava. roman.kula@fnspo.cz
authors.forename: R
authors.initials: R
authors.lastname: Kula
authors.forename: V
authors.initials: V
authors.lastname: Chýlek
authors.forename: P
authors.initials: P
authors.lastname: Sklienka
authors.forename: P
authors.initials: P
authors.lastname: Szturz
authors.forename: J
authors.initials: J
authors.lastname: Tichý
authors.forename: J
authors.initials: J
authors.lastname: Neiser
authors.forename: J
authors.initials: J
authors.lastname: Jahoda
mesh_terms: D001803:Blood Transfusion; D006801:Humans; D007108:Immune Tolerance; D008171:Lung Diseases / Q000209:etiology*; D065227:Transfusion Reaction