[The effect of prenatal stress on the carboxypeptidase H activity in the hypothalamo-pituitary-adrenal-gonadal system of the rat].
Effects of dams stress on the carboxypeptidase H: the neuropeptide exchange enzyme in the hypothalamo-pituitary-adrenall-gonadal system, was studied in the litter of different age (0, 14, 28, 45, and 120 day after birth) was studied. The sex differences in dynamic of enzyme activity in intact animals are substantiated. The effect of prenatal stress on carboxypeptidase H activity dependes on age and sex of animals. Prenatal stress is altering during the age dynamics of enzyme activity. This in the pituitary gland and hypothalamus of prenatal stressed female rats was a control for the male rats. In the adrenal and gonadal gland of prenatal stressed males, this was a control for the female rats female. The role of carboxypeptidase H in pubescence and mechanisms of effect of prenatal stress on sex system functional are discussed.
Vernigora
A N
AN
Balykova
N V
NV
Gengin
M T
MT
D000818:Animals; D000831:Animals, Newborn; D043423:Carboxypeptidase H / Q000378:metabolism*; D004789:Enzyme Activation; D005260:Female; D006066:Gonads / Q000033:anatomy & histology / Q000201:enzymology*; D007030:Hypothalamo-Hypophyseal System / Q000201:enzymology*; D008297:Male; D010913:Pituitary-Adrenal System / Q000201:enzymology*; D011247:Pregnancy; D051381:Rats; D013315:Stress, Psychological / Q000201:enzymology*
D043423:Carboxypeptidase H