Apolipoprotein E epsilon4 allele is associated with Parkinson disease risk in a Mexican Mestizo population.
We investigated the association between apolipoprotein E (APOE) alleles and genotypes and Parkinson disease (PD) in 229 unrelated Mexican Mestizo PD patients and 229 controls. Results showed that both APOE-epsilon4 allele and APOE epsilon4/epsilon3 genotype are associated with PD (OR = 1.736, P = 0.011; OR = 1.688, P = 0.019, respectively). Mean age at onset of PD was not associated to any APOE allele or genotype, but was significantly earlier in familial PD when compared to sporadic cases (P = 0.025).
López
Marisol
M
Department of Biological Systems, Universidad Autónoma Metropolitana Xochimilco, Mexico City, Mexico.
Guerrero
Jorge
J
Yescas
Petra
P
Boll
Marie-Catherine
MC
Familiar
Itziar
I
Ochoa
Adriana
A
Rasmussen
Astrid
A
Alonso
María Elisa
ME
D017668:Age of Onset; D000368:Aged; D053327:Apolipoprotein E4 / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008800:Mexico / Q000453:epidemiology; D008875:Middle Aged; D010300:Parkinson Disease / Q000453:epidemiology* / Q000235:genetics*; D012306:Risk
D053327:Apolipoprotein E4