Polo delivers a PICH to the kinetochore.
In this issue, Baumann et al. (2007) identify a helicase PICH that localizes to "threads" that remain connected between sister kinetochores after they have separated in anaphase. These threads are thought to be catenated centromeric DNA. PICH contributes to the mitotic checkpoint by recruiting Mad2 to kinetochores and is proposed to regulate checkpoint signaling by monitoring tension at centromeres.
Yen
Tim J
TJ
Fox Chase Cancer Center, Philadelphia, PA 19083, USA. timothy.yen@fccc.edu
D000595:Amino Acid Sequence; D018797:Cell Cycle Proteins / Q000378:metabolism*; D002843:Chromatin / Q000378:metabolism; D004265:DNA Helicases / Q000737:chemistry / Q000172:deficiency / Q000378:metabolism*; D006801:Humans; D018386:Kinetochores / Q000378:metabolism*; D008969:Molecular Sequence Data; D011485:Protein Binding; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D017434:Protein Structure, Tertiary; D021381:Protein Transport; D011518:Proto-Oncogene Proteins / Q000378:metabolism*; D008941:Spindle Apparatus / Q000378:metabolism; D013379:Substrate Specificity; D000097869:Polo-Like Kinase 1
D018797:Cell Cycle Proteins; D002843:Chromatin; D004265:DNA Helicases; D017346:Protein Serine-Threonine Kinases; D011518:Proto-Oncogene Proteins; D000097869:Polo-Like Kinase 1; C516980:ERCC6L protein, human