[Security evaluation of subcutaneous injection with water-based dextran-coated magnetic fluid].
Water-based magnetic fluid was synthesized by using 50% dextran 40,000 as coated reagent. The acute toxicity and irritant of the magnetic fluid injected into mice subcutaneous tissues were examined. The lethal dosage 50 of dextran-coated magnetic fluid was 4409.61 +/- 514.93 mg/kg. Twenty four h after subcutaneous injecting with 30 mg/0.3 ml dextran-coated magnetic fluid, no more inflammation than hemangiectasia and leucocytes infiltration had been seen in subcutaneous tissues, 72 h later the reaction phenomena disappeared. While, injection with 30 mg/0.3 ml water-based oleate sodium-coated magnetic fluid, ulceration and break-off of cutis had been seen in the seventh days. That is to say, the dextran-coated magnetic fluid was safe and well tolerate, however, the oleate sodium-coated magnetic fluid was not fit to subcutaneous injection.
Zhai
Yu
Y
Engineering Research Center for Nano Science and Technology, Shanghai Jiaotong University, Shanghai 200030, China. yzhai@sjtu.edu.cn
Wang
Xiaoliang
X
Wang
Xuman
X
Xie
Hong
H
Gu
Hongchen
H
D000818:Animals; D020099:Coated Materials, Biocompatible / Q000633:toxicity*; D003911:Dextrans / Q000633:toxicity*; D005260:Female; D052203:Ferrosoferric Oxide / Q000633:toxicity*; D007279:Injections, Subcutaneous; D008280:Magnetics; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D011897:Random Allocation
D020099:Coated Materials, Biocompatible; D003911:Dextrans; D052203:Ferrosoferric Oxide