title: Environmental tobacco smoke exposure and respiratory syncytial virus infection in young children hospitalized with acute lower respiratory tract infection.
abstract: OBJECTIVE
  The present study was performed to determine the relationship between environmental tobacco smoke (ETS) exposure and acute lower respiratory tract infection (LRI) caused by respiratory syncytial virus (RSV) in children.
  
  
  METHODS
  The authors did the study in 71 children (median age 12 months; 60% male) who were admitted to King Chulalongkorn Memorial Hospital with acute LRI between June and September 2004. 27% had RSV infection.
  
  
  RESULTS
  RSV-LRI required longer duration of oxygen therapy than non RSV-LRI (4.5 +/- 1.7 vs 2.8 +/- 1.3 days; p < 0.001). Desaturation in room air was more common in the former group compared to the latter group (37 vs 11%; p = 0.01). There was no difference in urinary cotinine level between the two groups (median 0.5 vs 0.6 mcg/mg Cr; ns). Among RSV-LRI, those with desaturation had higher urinary cotinine level than those without desaturation (median 0.8 vs 0.0 mcg/mg Cr; p = 0.04).
  
  
  CONCLUSIONS
  ETS exposure was not associated with RSV-LRI but increased the risk of desaturation in these patients.
authors.affiliation: Division of Pediatric Pulmonology and Critical Care, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Rama IV Rd, Bangkok 10330, Thailand. suchadacu@hotmail.com
authors.forename: Suchada
authors.initials: S
authors.lastname: Sritippayawan
authors.forename: Nuanchan
authors.initials: N
authors.lastname: Prapphal
authors.forename: Piansak
authors.initials: P
authors.lastname: Wong
authors.forename: Piyaratana
authors.initials: P
authors.lastname: Tosukhowong
authors.forename: Rujipat
authors.initials: R
authors.lastname: Samransamruajkit
authors.forename: Jitladda
authors.initials: J
authors.lastname: Deerojanawong
mesh_terms: D000208:Acute Disease; D016009:Chi-Square Distribution; D002675:Child, Preschool; D003367:Cotinine / Q000652:urine; D004781:Environmental Exposure; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D016015:Logistic Models; D008297:Male; D010102:Oxygen Inhalation Therapy; D018357:Respiratory Syncytial Virus Infections / Q000453:epidemiology* / Q000628:therapy; D018709:Statistics, Nonparametric; D013785:Thailand / Q000453:epidemiology; D014028:Tobacco Smoke Pollution / Q000009:adverse effects*; D016896:Treatment Outcome
chemical_list: D014028:Tobacco Smoke Pollution; D003367:Cotinine