Neutrophils as potential therapeutic targets in sepsis.
Neutrophils are important, expeditious front-line "soldiers" in fighting against bacterial infection. In sepsis, the overwhelming immune response to bacterial infection precipitates systemic inflammation and organ dysfunction. Neutrophils release many lysis-inducing factors and cause local tissue damage, and neutrophils themselves became a target in controlling sepsis.
Brown
K Alun
KA
Division of Medical Education, The Rayne Institute, St. Thomas' Hospital, London SE1 7EH, UK.
Treacher
David F
DF
D000818:Animals; D001424:Bacterial Infections / Q000150:complications / Q000503:physiopathology; D006801:Humans; D008954:Models, Biological; D009504:Neutrophils / Q000276:immunology* / Q000378:metabolism; D018805:Sepsis / Q000276:immunology* / Q000378:metabolism / Q000473:pathology