The PTHrP/PTH.1-R bioregulation system in cardiac hypertrophy: possible therapeutic implications.
Myocardial hypertrophy is associated with specific histological changes, which are representative of the cardiomyocytes cellular response to overload. Evidently, transcriptional modulation of specific genes is implicated in myocardial hypertrophy. Recently, the parathyroid hormone-related protein (PTHrP)/PTH-1 receptor (PTH-1.R) bioregulation system was shown to participate in specific regulatory processes of the cardiomyocyte function and proliferation, which can be related to cardiac hypertrophy and heart failure. We review the literature on the pathophysiology of cardiac hypertrophy vis-a-vis the role of PTHrP/PTH-1.R system as a good therapeutic target.
Halapas
Antonis
A
Department of Experimental Physiology, , University of Athens, Medical School, Greece.
Diamanti-Kandarakis
Evanthia
E
Kremastinos
Demetrios
D
Koutsilieris
Michael
M
D000818:Animals; D006332:Cardiomegaly / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology*; D006321:Heart / Q000503:physiopathology; D006801:Humans; D006961:Hyperparathyroidism / Q000150:complications; D008954:Models, Biological; D009206:Myocardium / Q000378:metabolism / Q000473:pathology; D044162:Parathyroid Hormone-Related Protein / Q000097:blood / Q000502:physiology*; D044168:Receptor, Parathyroid Hormone, Type 1 / Q000502:physiology*
D044162:Parathyroid Hormone-Related Protein; D044168:Receptor, Parathyroid Hormone, Type 1