Cytokine receptor signaling through the Jak-Stat-Socs pathway in disease.
The complexity of multicellular organisms is dependent on systems enabling cells to respond to specific stimuli. Cytokines and their receptors are one such system, whose perturbation can lead to a variety of disease states. This review represents an overview of our current understanding of the cytokine receptors, Janus kinases (Jaks), Signal transducers and activators of transcription (Stats) and Suppressors of cytokine signaling (Socs), focussing on their contribution to diseases of an immune or hematologic nature.
O'Sullivan
Lynda A
LA
School of Life & Environmental Sciences, Deakin University, 221 Burwood Highway, Burwood, Victoria 3125, Australia.
Liongue
Clifford
C
Lewis
Rowena S
RS
Stephenson
Sarah E M
SE
Ward
Alister C
AC
D000818:Animals; D006402:Hematologic Diseases / Q000276:immunology*; D006801:Humans; D007154:Immune System Diseases / Q000276:immunology*; D053612:Janus Kinases / Q000378:metabolism*; D018121:Receptors, Cytokine / Q000378:metabolism*; D050791:STAT Transcription Factors / Q000378:metabolism*; D015398:Signal Transduction; D050826:Suppressor of Cytokine Signaling Proteins / Q000378:metabolism*
D018121:Receptors, Cytokine; D050791:STAT Transcription Factors; D050826:Suppressor of Cytokine Signaling Proteins; D053612:Janus Kinases