Eosinophilic pneumonia induced by daptomycin.
We present a case of drug-induced eosinophilic pneumonia resulting from intravenous daptomycin being used as therapy for recurrent methicillin-sensitive Staphlococcus aureus endocarditis. The patient developed hypoxic respiratory failure requiring intubation and mechanical ventilation. Daptomycin therapy was discontinued immediately, and the patient improved significantly after the administration of intravenous corticosteroids allowing for extubation 3 days later.
Hayes
Don
D
Department of Pediatrics, University of Kentucky College of Medicine, J410 Kentucky Clinic, Lexington, KY 40536, USA. don.hayes@uky.edu <don.hayes@uky.edu>
Anstead
Michael I
MI
Kuhn
Robert J
RJ
D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D017576:Daptomycin / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D004697:Endocarditis, Bacterial / Q000188:drug therapy* / Q000382:microbiology*; D006801:Humans; D008297:Male; D008712:Methicillin / Q000494:pharmacology; D008875:Middle Aged; D011657:Pulmonary Eosinophilia / Q000139:chemically induced*; D013203:Staphylococcal Infections / Q000188:drug therapy / Q000382:microbiology; D013211:Staphylococcus aureus / Q000187:drug effects*
D000900:Anti-Bacterial Agents; D017576:Daptomycin; D008712:Methicillin