[Studies on HPLC fingerprint of cortex moutan].
OBJECTIVE
To establish a HPLC fingerprint for quality evaluation of Cortex Moutan.


METHODS
The HPLC chromatographic fingerprinting of 30 lots of Cortex Moutan was established and major peaks were identified by LC-MS and MS-MS.


RESULTS
The HPLC fingerprint of Cortex Moutan was established, showing 15 characteristic peaks. The areas of these peaks were found to complied with the following rule: paeonol > 1, 2, 3, 4, 6-penta-O-galloyl-glucos > methyl gallate > galloylpaeoniflorin > gallic acid > oxypaeoniflorin > other compounds.


CONCLUSIONS
The chromatographic fingerprinting of Cortex Moutan with high specificity can be used to control its quality and monitor lot to lot consistency.
Xu
Shun-Jun
SJ
Department of Pharmacognosy, China Pharmaceutical University, Nanjing 210038, China.
Li
Peng
P
Yang
Liu
L
Zhang
Mian
M
Wang
Zheng-Tao
ZT
D000098:Acetophenones / Q000032:analysis; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000032:analysis; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D004365:Drugs, Chinese Herbal / Q000032:analysis / Q000737:chemistry* / Q000145:classification; D005707:Gallic Acid / Q000031:analogs & derivatives / Q000032:analysis; D005960:Glucosides / Q000032:analysis; D047348:Hydrolyzable Tannins / Q000032:analysis; D039821:Monoterpenes / Q000032:analysis; D029596:Paeonia / Q000737:chemistry* / Q000145:classification; D024301:Plant Bark / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D011786:Quality Control
D000098:Acetophenones; D019086:Bridged Bicyclo Compounds, Heterocyclic; D004365:Drugs, Chinese Herbal; D005960:Glucosides; D047348:Hydrolyzable Tannins; D039821:Monoterpenes; C119233:galloylpaeoniflorin; C038881:moutan cortex; C047593:oxypaeoniflora; C013638:paeonol; C435084:pentagalloylglucose; C052082:methyl gallate; D005707:Gallic Acid