Biological functions of TRPs unravelled by spontaneous mutations and transgenic animals.
The identification of the biological functions of TRP (transient receptor potential) proteins requires genetic approaches because a selective TRP channel pharmacology to unravel the roles of TRPs is not available so far for most TRPs. A survey is therefore presented of transgenic animal models carrying mutations in TRP genes, as well as of those TRP genes that when mutated result in human disease; the chromosomal locations of TRP channel genes in the human and mouse are also presented.
Freichel
M
M
Experimentelle und Klinische Pharmakologie und Toxikologie, Gebäude 46, Medizinische Fakultät, Universität des Saarlandes, 66421 Homburg, Germany. ptmfre@uniklinikum-saarland.de
Flockerzi
V
V
D000818:Animals; D030801:Animals, Genetically Modified; D004195:Disease Models, Animal; D006801:Humans; D051379:Mice; D008954:Models, Biological; D008957:Models, Genetic; D009154:Mutation; D009369:Neoplasms / Q000235:genetics; D010641:Phenotype; D050051:Transient Receptor Potential Channels / Q000737:chemistry / Q000502:physiology*
D050051:Transient Receptor Potential Channels