Design of novel antifungal mucoadhesive films. Part II. Formulation and in vitro biopharmaceutical evaluation.
This paper deals with the formulation of the mucoadhesive films containing nystatin. The design and formulation of the films were based on the mucoadhesive properties of carbomer 934P (CB) and carboxymethycellulose (NaCMC), and also on the plasticizer properties of polyethyleneglycol 400 (PEG400). A surfactant (ascorbyl palmitate, ASC16) was added to the system to aid in nystatin dispersion. Addition of these last two components produced a significant improvement in physical-mechanical properties (flexibility and strength) as well as an increase in the nystatin release rate. X-ray powder diffraction (XRPD) and scanning electronic microscopy (SEM) were used to evaluate the morphological changes in the films while PEG400 and ASC16 were added to the formulations. Furthermore, the in vitro nystatin profile release was determined.
Llabot
J M
JM
Departamento de Farmacia, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, 5000 Córdoba, Argentina.
Palma
S D
SD
Manzo
R H
RH
Allemandi
D A
DA
D000180:Acrylic Resins / Q000737:chemistry*; D000268:Adhesiveness; D000935:Antifungal Agents / Q000008:administration & dosage / Q000737:chemistry*; D001205:Ascorbic Acid / Q000031:analogs & derivatives; D002266:Carboxymethylcellulose Sodium / Q000737:chemistry*; D003692:Delayed-Action Preparations; D008855:Microscopy, Electron, Scanning; D009092:Mucous Membrane / Q000378:metabolism; D009761:Nystatin / Q000008:administration & dosage / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry; D011108:Polymers / Q000737:chemistry; D012995:Solubility; D013678:Technology, Pharmaceutical; D014961:X-Ray Diffraction
D000180:Acrylic Resins; D000935:Antifungal Agents; D003692:Delayed-Action Preparations; D011108:Polymers; D009761:Nystatin; D011092:Polyethylene Glycols; C006903:carbopol 940; D002266:Carboxymethylcellulose Sodium; D001205:Ascorbic Acid; C031226:6-O-palmitoylascorbic acid