Caries-related saliva properties in individuals with 22q11 deletion syndrome.
OBJECTIVE
The aims were to compare saliva secretion rate, buffer capacity, cariogenic bacteria, total protein, IgA, and electrolytes between patients with 22q11 deletion syndrome (22q11DS) and control subjects and to study correlations between saliva and serum levels of IgA and electrolytes in 22q11DS patients.


METHODS
Twenty-nine consecutive 22q11DS patients (mean age 12.6 years) and matched healthy control subjects were clinically examined, and stimulated saliva samples were collected.


RESULTS
Patients with 22q11DS had impaired salivary secretion rate (P < .01) and buffer capacity (P < .05), higher numbers of cariogenic bacteria (P < .01), increased saliva protein concentrations (P < .001), and reduced output of electrolytes (P < .001-.05) compared with control subjects. A correlation between concentration in serum and saliva was found only for IgA (r = .622; P < .01).


CONCLUSIONS
Different salivary components were affected in patients with 22q11DS, which may explain the increased caries risk seen in these patients.
Klingberg
Gunilla
G
Mun-H-Center, National Orofacial Resource Center, Göteborg, Sweden. gunilla.klingberg@vgregion.se
Lingström
Peter
P
Oskarsdóttir
Sólveig
S
Friman
Vanda
V
Bohman
Eva
E
Carlén
Anette
A
D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D002872:Chromosome Deletion; D002892:Chromosomes, Human, Pair 22 / Q000235:genetics*; D003731:Dental Caries / Q000097:blood / Q000382:microbiology*; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D008297:Male; D012463:Saliva / Q000737:chemistry* / Q000378:metabolism; D012471:Salivary Proteins and Peptides / Q000032:analysis; D012472:Salivation; D018709:Statistics, Nonparametric; D013577:Syndrome
D007070:Immunoglobulin A; D012471:Salivary Proteins and Peptides