In vitro bioactivity of novel tricalcium silicate ceramics.
In this study, bone-like apatite-formation ability of tricalcium silicate (Ca(3)SiO(5)) ceramics in simulated body fluid (SBF) was evaluated and the in vitro degradability was investigated by soaking in Ringer's solution. The effect of ionic products from Ca(3)SiO(5) dissolution on osteobalsts proliferation was investigated. The result indicated that hydroxyapatite (HA) was formed on the surface of the Ca(3)SiO(5) ceramics after soaking in SBF for 1 day, and Ca(3)SiO(5) ceramics could degraded in Ringer's solution. The Si ions from Ca(3)SiO(5) dissolution at certain concentration range significantly stimulated osteoblasts proliferation. Our results show that Ca(3)SiO(5) ceramics possess bone-like apatite-formation ability and degradability, and can release soluble ionic products to stimulate cell proliferation.
Zhao
Wenyuan
W
Biomaterials and Tissue Engineering Research Center, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, PR China.
Chang
Jiang
J
Wang
Junying
J
Zhai
Wanyin
W
Wang
Zheng
Z
D020341:Absorbable Implants; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D001826:Body Fluids; D018786:Bone Substitutes / Q000737:chemistry; D017610:Calcium Compounds / Q000737:chemistry*; D049109:Cell Proliferation; D002478:Cells, Cultured; D002516:Ceramics / Q000737:chemistry*; D017886:Durapatite / Q000378:metabolism; D066298:In Vitro Techniques; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D010006:Osteoblasts / Q000166:cytology / Q000378:metabolism; D051381:Rats; D017640:Silicates / Q000737:chemistry*; D014961:X-Ray Diffraction
D001672:Biocompatible Materials; D018786:Bone Substitutes; D017610:Calcium Compounds; D017640:Silicates; C506393:tricalcium silicate; D017886:Durapatite