Adenovirus type 11 binding alters the conformation of its receptor CD46.
Adenoviruses (Ads) are important human pathogens and valuable gene delivery vehicles. We report here the crystal structure of the species B Ad11 knob complexed with the Ad11-binding region of its receptor CD46. The conformation of bound CD46 differs profoundly from its unbound state, with the bent surface structure straightened into an elongated rod. This mechanism of interaction is likely to be conserved among many pathogens that target CD46 or related molecules.
Persson
B David
BD
Interfaculty Institute for Biochemistry, University of Tübingen, D-72076 Tübingen, Germany.
Reiter
Dirk M
DM
Marttila
Marko
M
Mei
Ya-Fang
YF
Casasnovas
José M
JM
Arnberg
Niklas
N
Stehle
Thilo
T
D000260:Adenoviruses, Human / Q000378:metabolism*; D001665:Binding Sites; D018360:Crystallography, X-Ray; D006801:Humans; D008958:Models, Molecular; D011487:Protein Conformation; D011991:Receptors, Virus / Q000737:chemistry* / Q000378:metabolism; D014764:Viral Proteins / Q000737:chemistry* / Q000378:metabolism
D011991:Receptors, Virus; D014764:Viral Proteins; C085301:adenovirus receptor