Recurrent unbalanced whole-arm t(1;10)(q10;p10) in myelodysplastic syndrome: a case report and literature review.
We report a patient with myelodysplastic syndrome (refractory anemia) showing the karyotype 46,XY,+1,der(1;10)(q10;p10), resulting in trisomy 1q and monosomy 10q abnormality. This finding suggests that either trisomy of 1q or centromeric connection between chromosomes 1 and 10, rather than the absence of 10q, might be essential toward neoplastic transformation.
Odish
Omar Ferkad Faraj
OF
The First Department of Internal Medicine (Hematology/Oncology Division), Tokyo Medical University, 6-7-1 Nishi-shinjuku, Shinjuku-ku, Tokyo 160-0023, Japan.
Gotoh
Akihiko
A
Liu
Yi-Chang
YC
Shoji
Nohoko
N
Kimura
Yukihiko
Y
Kodama
Atsushi
A
Ohyashiki
Kazuma
K
D022981:Allelic Imbalance; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics*; D002879:Chromosomes, Human, Pair 10 / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000235:genetics*; D009364:Neoplasm Recurrence, Local / Q000235:genetics*; D014178:Translocation, Genetic