Influence of cyclosporin A on quality of bone around integrated dental implants: a radiographic study in rabbits.
OBJECTIVE
To evaluate the influence of cyclosporin A (CsA) administration on bone around integrated dental implants assessed by a bone quality index and by quantitative subtraction radiography.


METHODS
A total of 36 machine surface commercial implants were placed in 18 adult rabbits. After a 3-month healing period without any disturbance, the animals were randomly divided into three groups of six animals each. Group A was sacrificed at this time. CsA was injected subcutaneously in an immunosuppressive dose of 10 mg/kg/day in a test group (Group T), and a Group B served as a control, receiving only vehicle. After 3 months of cyclosporin administration, the animals of both Groups B and T were sacrificed. Radiographs were obtained at implant surgery and at the day of sacrifice with a CMOS sensor. Bone quality around the implants was compared between the groups using a bone quality index and quantitative subtraction radiography.


RESULTS
The bone analysis showed that in Group T, the bone quality changed dramatically from a dense cortical to a loose trabecular bone structure (P<0.0001, chi(2) test) while in Groups A and B there were no significant differences. Quantitative digital subtraction radiography showed significantly (P<0.05) lower gray shade values (radiographic density) in a region of bone formation around the implants in Group T (118+/-12) than in Groups A (161+/-6) and B (186+/-10).


CONCLUSIONS
Within the limits of this study, CsA administration has a negative effect on the quality of bone around integrated dental implant.
Sakakura
Celso Eduardo
CE
Department of Oral Diagnosis and Surgery, School of Dentistry, State University of São Paulo, UNESP, Araraquara, SP, Brazil.
Marcantonio
Elcio
E
Wenzel
Ann
A
Scaf
Gulnara
G
D000818:Animals; D015519:Bone Density / Q000187:drug effects*; D016723:Bone Remodeling / Q000187:drug effects; D016572:Cyclosporine / Q000494:pharmacology*; D015921:Dental Implants; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D016348:Osseointegration / Q000187:drug effects / Q000502:physiology; D010919:Placebos; D011817:Rabbits; D011856:Radiographic Image Enhancement; D011897:Random Allocation; D013382:Subtraction Technique; D013977:Tibia / Q000000981:diagnostic imaging / Q000187:drug effects*; D013997:Time Factors; D014945:Wound Healing / Q000502:physiology
D015921:Dental Implants; D007166:Immunosuppressive Agents; D010919:Placebos; D016572:Cyclosporine