title: Surgical management of Paget's disease of bone.
abstract: Paget's disease is a chronic nonmetabolic bone disorder that is characterized by increased bone resorption, bone formation, and remodeling. This unbalanced process may lead to osseous deformities, structural weakness, and altered joint biomechanics, all of which can make surgical reconstruction difficult. Although few patients with Paget's disease ever need surgical treatment, successful surgical management of orthopedic manifestations of the disease has improved the quality of life for these patients. Surgical options include corrective osteotomy for long bone deformity, fracture fixation, joint arthroplasty, spinal decompression, and tumor resection. Patients are at increased risk for surgical complications such as blood loss and heterotopic bone formation. Issues relating to the surgical management of patients with Paget's disease such as appropriate preoperative diagnosis, technical challenges of surgery, and strategies to improve the long-term outcome of surgical intervention are discussed.
authors.affiliation: Rothman Institute of Orthopedics, Thomas Jefferson Hospital, Philadelphia, Pennsylvania, USA.
authors.forename: Javad
authors.initials: J
authors.lastname: Parvizi
authors.forename: Gregg R
authors.initials: GR
authors.lastname: Klein
authors.forename: Franklin H
authors.initials: FH
authors.lastname: Sim
mesh_terms: D001706:Biopsy; D006801:Humans; D019637:Orthopedic Procedures / Q000706:statistics & numerical data*; D010001:Osteitis Deformans / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D011859:Radiography