title: Safety and efficacy of catheter ablation of atrial fibrillation in patients with diabetes mellitus--single center experience.
abstract: OBJECTIVE
  Little is known about the outcome of catheter ablation of atrial fibrillation (AF) in patients with diabetes mellitus (DM). We investigated the safety and efficacy of catheter ablation of AF in patients with DM.
  
  
  METHODS
  Thirty one patients with DM from a group of 263 consecutive patients undergoing a first-time catheter ablation of AF procedure were enrolled in a prospective study. The ablation protocol (guided by CARTO system) consisted in two continuous circular lesions around ipsilateral pulmonary veins.
  
  
  RESULTS
  The following clinical characteristics differed between DM and no-DM patients: age (62.0 +/- 10.8 vs. 56.1 +/- 10.6 years, P = 0.004), longer AF history (9.6 +/- 9.3 vs. 6.7 +/- 6.3 years, P = 0.024), significantly larger left atrium size (41.1 +/- 7.8 vs. 38.3 +/- 5.8 mm, P = 0.021), hypertension (58.1 vs. 35.8%, P = 0.018) and structural heart disease (67.7 vs. 43.5%, P = 0.011). Despite a similar AF recurrence rate in DM and no-DM patients (32.3 vs. 22.4%, P = 0.240), the ablation procedure was complicated in 28 patients (11 hematomas, three cardiac tamponades and three strokes) and the incidence of complications was significantly higher in DM than in no-DM patients (29.0 vs. 8.2%, respectively, P = 0.002). Multivariate analysis showed that DM was an independent risk factor for complications occurrence (odd ratio 5.936, 95% confidence interval 2.059 to 17.112, P = 0.001).
  
  
  CONCLUSIONS
  First catheter ablation of AF procedure in DM patients was equally efficacious than in no-DM patients. However, DM patients had a higher incidence of complications, mostly thrombotic or hemorrhagic.
authors.affiliation: Department of Cardiology, Beijing Anzhen Hospital, Capital University of Medical Sciences, Beijing, China. tangribo1994@yahoo.com.cn
authors.forename: Ri Bo
authors.initials: RB
authors.lastname: Tang
authors.forename: Jian Zeng
authors.initials: JZ
authors.lastname: Dong
authors.forename: Xing Peng
authors.initials: XP
authors.lastname: Liu
authors.forename: Dong Ping
authors.initials: DP
authors.lastname: Fang
authors.forename: De Yong
authors.initials: DY
authors.lastname: Long
authors.forename: Xiao Hui
authors.initials: XH
authors.lastname: Liu
authors.forename: Rong Hui
authors.initials: RH
authors.lastname: Yu
authors.forename: Fu Li
authors.initials: FL
authors.lastname: Hu
authors.forename: Chun Shan
authors.initials: CS
authors.lastname: Lu
authors.forename: Peng
authors.initials: P
authors.lastname: Hao
authors.forename: Jérôme
authors.initials: J
authors.lastname: Kalifa
authors.forename: Chang Sheng
authors.initials: CS
authors.lastname: Ma
mesh_terms: D001281:Atrial Fibrillation / Q000453:epidemiology* / Q000601:surgery*; D017115:Catheter Ablation / Q000706:statistics & numerical data*; D002681:China / Q000453:epidemiology; D015897:Comorbidity; D003920:Diabetes Mellitus / Q000453:epidemiology* / Q000601:surgery*; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000453:epidemiology*; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D016896:Treatment Outcome