title: Cytogenetics detects infiltrations of a primary cutaneous acute myeloid leukemia to the kidney.
abstract: Extramedullary manifestations of acute myeloid leukemia (AML) are rare and commonly involve one tissue. We report of a cutaneous acute myelomonocytic leukemia infiltrating the kidney next to the skin. A 61-year-old female patient with complex karyotype cutaneous AML FAB M4 underwent abdominal computed tomography scans. A lesion in her left kidney appeared suspicious of renal carcinoma as confirmed by histology. However, fluorescence in situ hybridization cytogenetics revealed a chromosome 11q23 abnormality in the nephrectomy specimen, which also appeared in the leukemic blasts of skin and bone marrow. Closer histomorphologic workup revealed an infiltration of the kidney with leukemia. This case report illustrates how modern diagnostic procedures can help to reveal rare sites of disease.
authors.forename: Maximilian
authors.initials: M
authors.lastname: Christopeit
authors.forename: Lutz Peter
authors.initials: LP
authors.lastname: Mueller
authors.forename: Michael
authors.initials: M
authors.lastname: Hainz
authors.forename: Hans-Jürgen
authors.initials: HJ
authors.lastname: Holzhausen
authors.forename: Gerhard
authors.initials: G
authors.lastname: Behre
mesh_terms: D002869:Chromosome Aberrations; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D007668:Kidney / Q000378:metabolism / Q000473:pathology*; D015479:Leukemia, Myelomonocytic, Acute / Q000235:genetics / Q000473:pathology*; D017254:Leukemic Infiltration / Q000473:pathology*; D008875:Middle Aged; D051788:Myeloid-Lymphoid Leukemia Protein / Q000235:genetics; D012878:Skin Neoplasms / Q000235:genetics / Q000473:pathology*
chemical_list: D051788:Myeloid-Lymphoid Leukemia Protein