Stable carbamazepine colloidal systems using the cosolvent technique.
The aim of this paper was to prepare stable carbamazepine nanosuspensions containing 10mg/ml drug concentration by screening different polymers. Stable formulations were created by the cosolvent technique with polyethylene glycol (PEG-300) and water as the cosolvents. Rapid growth of long needle shaped CBZ crystals was observed in the absence of polymer. The presence of hydroxypropyl methylcellulose (HPMC) or methylcellulose (MC) inhibited crystal growth and the mean particle sizes were in the range 10-20 nm. Simultaneous presence of HPMC and polyvinylpyrrolidon (PVP PF17) polymers in CBZ suspensions enhanced the overall stability of the formulations. The additional stability improvement was attributed to the interaction between the polymers by the formation of hydrogen bonds. Suspension stability was evaluated over 5 months where the particle size remained constant. FT-Raman studies showed the existence of form I within the stable CBZ suspensions.
Douroumis
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Department of Pharmaceutical Technology, University of Jena, Lessingstrasse 8, D-07743 Jena, Germany. dionysios.douroumis@phoqus.com
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D000927:Anticonvulsants / Q000737:chemistry*; D002220:Carbamazepine / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D003102:Colloids; D003460:Crystallization; D004339:Drug Compounding; D004355:Drug Stability; D005079:Excipients / Q000737:chemistry; D006860:Hydrogen Bonding; D065347:Hypromellose Derivatives; D008747:Methylcellulose / Q000031:analogs & derivatives / Q000737:chemistry; D053758:Nanoparticles; D010316:Particle Size; D011092:Polyethylene Glycols / Q000737:chemistry; D011205:Povidone / Q000737:chemistry; D012995:Solubility; D012997:Solvents / Q000737:chemistry*; D013059:Spectrum Analysis, Raman; D013678:Technology, Pharmaceutical / Q000379:methods*; D013997:Time Factors; D014867:Water / Q000737:chemistry
D000927:Anticonvulsants; D003102:Colloids; D005079:Excipients; D012997:Solvents; D014867:Water; D002220:Carbamazepine; D065347:Hypromellose Derivatives; D011092:Polyethylene Glycols; D008747:Methylcellulose; D011205:Povidone