title: Synthesis, cytotoxicity and structure-activity relationship study of terpyridines.
abstract: For the development of novel antitumor agents, we designed and synthesized terpyridines, and their biological activities were evaluated. Although most of the newly prepared terpyridines showed strong cytotoxicity against several human cancer cell lines, [2,2';6',2"]-terpyridine displayed the most significant cytotoxicity.
authors.affiliation: College of Pharmacy, Yeungnam University, Kyongsan 712-749, Korea.
authors.forename: Long-Xuan
authors.initials: LX
authors.lastname: Zhao
authors.forename: Jyoti
authors.initials: J
authors.lastname: Sherchan
authors.forename: Jung Ki
authors.initials: JK
authors.lastname: Park
authors.forename: Yurngdong
authors.initials: Y
authors.lastname: Jahng
authors.forename: Byeong-Seon
authors.initials: BS
authors.lastname: Jeong
authors.forename: Tae Cheon
authors.initials: TC
authors.lastname: Jeong
authors.forename: Chong-Soon
authors.initials: CS
authors.lastname: Lee
authors.forename: Eung-Seok
authors.initials: ES
authors.lastname: Lee
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000633:toxicity*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D006801:Humans; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D011725:Pyridines / Q000138:chemical synthesis* / Q000633:toxicity*; D013329:Structure-Activity Relationship; D059004:Topoisomerase I Inhibitors
chemical_list: C517923:(2,2'-6',2'')-terpyridine; D000970:Antineoplastic Agents; D007202:Indicators and Reagents; D011725:Pyridines; D059004:Topoisomerase I Inhibitors