A role for Wnt/planar cell polarity signaling during lens fiber cell differentiation?
Wnt signaling through frizzled (Fz) receptors plays key roles in just about every developmental system that has been studied. Several Wnt-Fz signaling pathways have been identified including the Wnt/planar cell polarity (PCP) pathway. PCP signaling is crucial for many developmental processes that require major cytoskeletal rearrangements. Downstream of Fz, PCP signaling is thought to involve the GTPases, Rho, Rac and Cdc42 and regulation of the JNK cascade. Here we report on the localization of these GTPases and JNK in the lens and assess their involvement in the cytoskeletal reorganisation that is a key element of FGF-induced lens fiber cell differentiation.
Chen
Y
Y
Save Sight Institute, The University of Sydney, NSW, Australia.
Stump
R J W
RJ
Lovicu
F J
FJ
McAvoy
J W
JW
D000818:Animals; D002454:Cell Differentiation / Q000502:physiology*; D016764:Cell Polarity / Q000502:physiology*; D007908:Lens, Crystalline / Q000166:cytology* / Q000196:embryology* / Q000502:physiology; D051381:Rats; D015398:Signal Transduction / Q000502:physiology*; D051153:Wnt Proteins / Q000502:physiology*
D051153:Wnt Proteins