title: [The role of cyclooxygenase on angiogenesis and endothelial progenitor cell mobilization in rat ischemic myocardium].
abstract: OBJECTIVE
  To investigate the effect of COX1 and COX2 on angiogenesis and endothelial progenitor cell mobilization in rats with experimental myocardial infarction (MI).
  
  
  METHODS
  The rats were randomly divided into 3 groups: MI group, MI plus rofecoxib group and MI plus valeryl salicylate group. At the 7th day after operation, circulating EPCs, plasma VEGF and HIF-1alpha mRNA of ischemic myocardium were measured. At the 28th day post operation, capillary densities were also measured in ischemic myocardium.
  
  
  RESULTS
  Compared with the MI group and the MI plus valeryl salicylate group, circulating EPCs, plasma VEGF, HIF-1alpha mRNA and capillary densities of ischemic myocardium were all decreased in MI plus rofecoxib group.
  
  
  CONCLUSIONS
  The present study revealed that COX2 play an important role with angiogenesis and endothelial progenitor cell mobilization in rat with experimental MI by modulating expression of VEGF and HIF-1alpha.
authors.affiliation: Centre of Cardiology, Xinqiao Hospital of Third Military Medical University, Chongqing 400037, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Zhou
authors.forename: Lan
authors.initials: L
authors.lastname: Huang
authors.forename: Jun
authors.initials: J
authors.lastname: Jin
authors.forename: Xiao-jing
authors.initials: XJ
authors.lastname: Wu
authors.forename: Yu-qiang
authors.initials: YQ
authors.lastname: Fang
authors.forename: Ming-bao
authors.initials: MB
authors.lastname: Song
authors.forename: Gang
authors.initials: G
authors.lastname: Zhao
authors.forename: Xiao-hui
authors.initials: XH
authors.lastname: Zhao
authors.forename: Yin-pin
authors.initials: YP
authors.lastname: Zhou
mesh_terms: D000818:Animals; D051546:Cyclooxygenase 2 / Q000096:biosynthesis; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology*; D042783:Endothelial Cells / Q000166:cytology; D005260:Female; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000096:biosynthesis; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000473:pathology; D018919:Neovascularization, Physiologic / Q000187:drug effects*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013234:Stem Cells / Q000378:metabolism; D042461:Vascular Endothelial Growth Factor A / Q000097:blood
chemical_list: D016861:Cyclooxygenase Inhibitors; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D042461:Vascular Endothelial Growth Factor A; D051546:Cyclooxygenase 2