Three new Cu(II) and Cd(II) complexes with 3-(2-pyridyl)pyrazole-based ligand: syntheses, crystal structures, and evaluations for bioactivities.
Three new complexes [Cu(L)(2)(NO(3))](NO(3))(H(2)O)(1/2)(CH(3)OH)(1/2) (1), [Cd(L)(2)(NO(3))(2)](H(2)O)(3) (2) and [Cd(L)(2)(ClO(4))(CH(3)OH)](ClO(4))(H(2)O)(1/4)(CH(3)OH) (3) (L=1-[3-(2-pyridyl)pyrazol-1-ylmethyl]naphthalene) were synthesized and characterized by elemental analyses, IR and X-ray diffraction analysis. Among them, the Cu(II) and Cd(II) ions were both coordinated by four N donors from two distinct L ligands via N,N-bidentate chelating coordination mode. Additional weak interactions, such as the face-to-face pi-pi stacking and C-Hcdots, three dots, centeredO H-bonding interactions, linked the mononuclear unit into 1D chain and further into 2D network. Complexes 1-3 were subjected to biological assays in vitro against six different cancer cell lines. All of them exhibited cytotoxic specificity and notable cancer cell inhibitory rate. The interactions of 1-3 with calf thymus DNA were investigated by thermal denaturation, viscosity measurements, spectrophotometric and electrophoresis methods. The results indicate that these complexes bound to DNA by intercalation mode via the ligand L and had different nuclease activities, which were in good agreement with their DNA-binding strength. Moreover, the central metal ions of 1-3 played a vital role in DNA-binding behaviors, DNA-cleavage activities and cytotoxicities, whereas the contribution of the different counter anions to their bioactivities also should not be ignored.
Chen
Ran
R
State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center, Beijing 100083, PR China.
Liu
Chun-Sen
CS
Zhang
Hang
H
Guo
Yue
Y
Bu
Xian-He
XH
Yang
Ming
M
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D002104:Cadmium / Q000737:chemistry*; D002417:Cattle; D045744:Cell Line, Tumor / Q000187:drug effects; D003300:Copper / Q000737:chemistry*; D018360:Crystallography, X-Ray; D004247:DNA / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D015394:Molecular Structure; D009691:Nucleic Acid Denaturation; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D013057:Spectrum Analysis; D014783:Viscosity
D000970:Antineoplastic Agents; D009942:Organometallic Compounds; C520132:dinitratobis(1-(3-(2-pyridyl)pyrazol-1-ylmethyl)naphthalene)copper(II); C520130:nitratobis(1-(3-(2-pyridyl)pyrazol-1-ylmethyl)naphthalene)copper(II); C520131:perchlorato(methanol)bis(1-(3-(2-pyridyl)pyrazol-1-ylmethyl)naphthalene)copper(II); D002104:Cadmium; D003300:Copper; D004247:DNA; C427203:calf thymus DNA