Highly efficient synthesis of enantiomerically enriched 2-hydroxymethylaziridines by enzymatic desymmetrization.
Both enantiomers of protected and unprotected 2-hydroxymethylaziridines are efficiently and enantiospecifically synthesized by using a combination of enzymatic and synthetic methods. PPL was used for lipase-catalyzed desymmetrization of N-protected serinol. [reaction: see text].
Choi
Jun Young
JY
Department of Medicinal Chemistry and Molecular Phamacology, Purdue University, West Lafayette, Indiana 47907, USA.
Borch
Richard F
RF
D000818:Animals; D001388:Aziridines / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D008049:Lipase / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D010179:Pancreas / Q000201:enzymology; D012680:Sensitivity and Specificity; D013237:Stereoisomerism; D013552:Swine
D001388:Aziridines; D008049:Lipase