[Myeloperoxidase in the plasma of patients with acute coronary syndrome].
OBJECTIVE
To determine the diagnostic value and efficacy for risk stratification of myeloperoxidase (MPO) levels in patients with acute coronary syndrome (ACS).


METHODS
One hundred and sixty-two patients were enrolled in this study. All patients underwent coronary angiography. They were divided into 3 groups: ACS group (n=54), SAP group (n=54) and control group (n=54). Blood samples were taken from the artery before angiography in all patients and the concentrations of MPO, hsCRP and cTnI were measured. Each subject was asked details of history of hypertension, hyperlipidemia, diabetes and smoking habits. The efficacy of therapy, the cardiovascular events (myocardial infarction, the need for revascularization, or death) were recorded after 6 months of follow-up.


RESULTS
The plasma MPO level in ACS group (30.98 ng/mL) was significantly higher than those in the SAP group (14.67 ng/mL) and the control group(14.23 ng/mL)(P<0.01), and the plasma MPO levels in patients of the SAP group and the control group were not significantly different (P=0.74). There was no obvious correlation between the levels of plasma MPO and the serum levels of cTnI, hsCRP,the prevalence of the 4 major risk factors for CHD. Multivariate logistic regression analysis showed that plasma MPO level, free plasma glucose and sex were the significant variables. The risk for subsequent cardiovascular events was higher in the patients with elevated level of MPO.


CONCLUSIONS
Plasma MPO may be a new risk biomarker for ACS and may predict the incidence of subsequent cardiovascular events.
Ouyang
Mao
M
Department of Cardiology, Third Xiangya Hospital, Central South University, Changsha 410013, China.
Yang
Kan
K
Zhang
Meng-xi
MX
Jiang
Wei-hong
WH
Cao
Yu
Y
Wang
Jian-gang
JG
Gao
Ying-dong
YD
D054058:Acute Coronary Syndrome / Q000097:blood* / Q000201:enzymology*; D000368:Aged; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009195:Peroxidase / Q000097:blood*
D015415:Biomarkers; D009195:Peroxidase