title: Phenolic Constituents of Selaginella doederleinii.
abstract: Eleven phenolic Compounds have been isolated from the ethanolic extract of SELAGINELLA DOEDERLEINII by a combination of Chromatographic techniques. These are five lignans: (-)-lirioresinol A, (-)-lirioresinol B, (+)-wikstromol, (-)-nortracheloside, (+)-matairesinol ( 1), two phenylpropanones: 3-hydroxy-1-(3-methoxy-4-hydroxyphenyl)-propan-1-one ( 2), 3-hydroxy-1-(3,5 -dimethoxy-4-hydroxyphenyl)-propan-1-one ( 3), and four biflavonoids: amentoflavone, 7,7''-di- O-methylamentoflavone, 7,4',7'',4'''-tetra- O-methylamentoflavone, and heveaflavone ( 4). Compounds 1, 2, and 3 are novel natural secondary metabolites. Their structures were deduced from their spectral data (mainly (1)H-NMR, mass, and CD). Lignans are described here for the first time in the family Selaginellaceae. Their cytotoxic activity against L 929 murine cells accounts for the use of the plant in traditional Chinese medicine as an anticancer agent.
authors.affiliation: Laboratoire de Pharmacognosie, U.R.A. au C.N.R.S. n° 1310, Faculté de Pharmacie, Université Paris V, 4 Avenue de l'Observatoire, F-75006 Paris, France.
authors.forename: R C
authors.initials: RC
authors.lastname: Lin
authors.forename: A L
authors.initials: AL
authors.lastname: Skaltsounis
authors.forename: E
authors.initials: E
authors.lastname: Seguin
authors.forename: F
authors.initials: F
authors.lastname: Tillequin
authors.forename: M
authors.initials: M
authors.lastname: Koch