The genetic and environmental basis of hepatocellular carcinoma.
Liver cancer is among the most common malignancies, impacting significantly across all societies worldwide. The lethal impact of this prevalent cancer is unlikely to change considerably in the near future due to a limited understanding of disease pathogenesis on the molecular, cellular, and environmental levels and how current knowledge might be converted into new preventive, therapeutic and diagnostic approaches. This article highlights the current challenges and opportunities in this critical area of unmet need.
Farazi
Paraskevi A
PA
Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. pfarazi@mit.edu
DePinho
Ronald A
RA
D016604:Aflatoxin B1 / Q000633:toxicity; D000437:Alcoholism / Q000150:complications; D006528:Carcinoma, Hepatocellular / Q000209:etiology*; D020022:Genetic Predisposition to Disease; D042822:Genomic Instability; D006526:Hepatitis C / Q000150:complications; D006801:Humans; D008113:Liver Neoplasms / Q000209:etiology*; D008954:Models, Biological
D016604:Aflatoxin B1