Microwave hyperthermia treatment increases heat shock proteins in human skeletal muscle.
OBJECTIVE
To test the hypothesis that microwave hyperthermia treatment (MHT) increases heat shock proteins (HSPs) in the human vastus lateralis muscle.


METHODS
Four untrained healthy male volunteers participated in this study. The lateral side of the thigh of one leg (heated leg) was heated with a microwave generator (2.5 GHz, 150 W) for 20 min. At 1 day after the MHT, a muscle sample was taken from the heated leg. A control sample was taken from the unheated leg on another day of the MHT. For both legs, HSP90, HSP72 and HSP27 levels were compared.


RESULTS
The HSP90, HSP72 and HSP27 levels in heated legs were significantly higher than those in control legs (p<0.05).


CONCLUSIONS
Application of MHT can increase the levels of several HSPs in human skeletal muscle.
Ogura
Yuji
Y
Institute of Health and Sports Science & Medicine, Juntendo University, Hiragagakuendai, Inba, Chiba, Japan. yuji-ogura@sakura.juntendo.ac.jp
Naito
Hisashi
H
Tsurukawa
Toshihiro
T
Ichinoseki-Sekine
Noriko
N
Saga
Norio
N
Sugiura
Takao
T
Katamoto
Shizuo
S
D000328:Adult; D015153:Blotting, Western; D001831:Body Temperature; D006360:Heat-Shock Proteins / Q000378:metabolism*; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D007866:Leg; D008297:Male; D008872:Microwaves / Q000627:therapeutic use*; D018482:Muscle, Skeletal / Q000293:injuries / Q000378:metabolism*; D009135:Muscular Diseases / Q000517:prevention & control*
D006360:Heat-Shock Proteins