title: Expression of survivin, CDK4, Ki-67 and clinical significance in pediatric acute leukemia.
abstract: The expression of Survivin, CDK4 and Ki-67 and the clinical significance in pediatric acute leukemia (AL) were investigated. The expression of Survivin, CDK4 and Ki-67 proteins was detected by using immunohistochemical assay in 37 children with AL and 10 children with normal bone marrow as controls. The positive expression rate of Survivin, CDK4 and Ki-67 was 45.9 %, 56.8 %, and 40.5 % respectively in 37 AL children, which was significantly higher than in control group accordingly (P<0.05). The expression of Survivin was positively correlated with CDK4 (P=0.007) and Ki-67 (P=0.008). In conclusion, all Survivin, CDK4 and Ki-67 proteins are over-expressed in pediatric AL and involved in the modulation of apoptosis and proliferation in pediatric AL.
authors.affiliation: Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
authors.forename: Liuqing
authors.initials: L
authors.lastname: Zhang
authors.forename: Jing
authors.initials: J
authors.lastname: Liu
authors.forename: Hanhua
authors.initials: H
authors.lastname: Lin
authors.forename: Qun
authors.initials: Q
authors.lastname: Hu
authors.forename: Aiguo
authors.initials: A
authors.lastname: Liu
authors.forename: Ying
authors.initials: Y
authors.lastname: Hu
mesh_terms: D000293:Adolescent; D017209:Apoptosis / Q000502:physiology; D049109:Cell Proliferation; D002648:Child; D002675:Child, Preschool; D051358:Cyclin-Dependent Kinase 4 / Q000378:metabolism*; D005260:Female; D006801:Humans; D007223:Infant; D051034:Inhibitor of Apoptosis Proteins / Q000378:metabolism*; D019394:Ki-67 Antigen / Q000378:metabolism*; D015470:Leukemia, Myeloid, Acute / Q000378:metabolism* / Q000473:pathology; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000378:metabolism* / Q000473:pathology; D000077022:Survivin
chemical_list: C107489:BIRC5 protein, human; D051034:Inhibitor of Apoptosis Proteins; D019394:Ki-67 Antigen; D000077022:Survivin; C495900:CDK4 protein, human; D051358:Cyclin-Dependent Kinase 4