title: Assessment of the potency and potential immunomodulatory effects of the measles mumps rubella and varicella vaccine in infants.
abstract: This study compared the potency and immunomodulatory effects of measles mumps rubella (MMR) vaccine given to infants alone or in combination with varicella (MMR and V). In an additional group, MMR vaccination was delayed 42 days to permit analysis of potential effects on underlying maturation of systemic immune functions. Assessment of immunity to the vaccines indicated consistent antibody production coupled with mixed Th1/Th2 memory, and no significant differences between vaccine groups or to the group who had their MMR vaccination delayed. Parallel analyses of cytokine responses to phytohaemagglutinin and tetanus toxoid did not detect any "bystander" effects of the vaccines on systemic immunity.
authors.affiliation: Telethon Institute for Child Health Research, and Centre for Child Health Research, Faculty of Medicine and Dentistry, The University of Western Australia, Perth, WA, Australia.
authors.forename: Stephanie T
authors.initials: ST
authors.lastname: Yerkovich
authors.forename: Julie
authors.initials: J
authors.lastname: Rowe
authors.forename: Peter
authors.initials: P
authors.lastname: Richmond
authors.forename: Devinda
authors.initials: D
authors.lastname: Suriyaarachchi
authors.forename: Tricia
authors.initials: T
authors.lastname: Heaton
authors.forename: Elysia
authors.initials: E
authors.lastname: Hollams
authors.forename: Claire
authors.initials: C
authors.lastname: Ladyman
authors.forename: Michael
authors.initials: M
authors.lastname: Serralha
authors.forename: Agata
authors.initials: A
authors.lastname: Sadowska
authors.forename: Richard
authors.initials: R
authors.lastname: Loh
authors.forename: Steven L
authors.initials: SL
authors.lastname: Wesselingh
authors.forename: Peter D
authors.initials: PD
authors.lastname: Sly
authors.forename: Patrick G
authors.initials: PG
authors.lastname: Holt
mesh_terms: D000914:Antibodies, Viral / Q000097:blood; D002644:Chickenpox / Q000276:immunology / Q000517:prevention & control*; D019433:Chickenpox Vaccine / Q000276:immunology*; D005260:Female; D006801:Humans; D007223:Infant; D007371:Interferon-gamma / Q000096:biosynthesis; D018793:Interleukin-13 / Q000096:biosynthesis; D015848:Interleukin-5 / Q000096:biosynthesis; D008297:Male; D008457:Measles / Q000276:immunology / Q000517:prevention & control*; D022542:Measles-Mumps-Rubella Vaccine / Q000276:immunology*; D009107:Mumps / Q000276:immunology / Q000517:prevention & control*; D012409:Rubella / Q000276:immunology / Q000517:prevention & control*; D013601:T-Lymphocytes / Q000276:immunology; D017778:Vaccines, Combined / Q000276:immunology
chemical_list: D000914:Antibodies, Viral; D019433:Chickenpox Vaccine; D018793:Interleukin-13; D015848:Interleukin-5; D022542:Measles-Mumps-Rubella Vaccine; D017778:Vaccines, Combined; C050102:measles, mumps, rubella, varicella vaccine; D007371:Interferon-gamma