Emerging strategies for pegylated interferon combination therapy.
Several advances afford promise for improving the management of hepatitis C virus (HCV) infection. Current therapies primarily target the immune system; the now proven ability to culture the entire virus in vitro could ultimately facilitate the identification of therapies directly targeting viral replication. Several therapies are presently in development. Taribavirin hydrochloride (Viramidine, Valeant Pharmaceutical International, Singapore), a ribavirin prodrug, has shown promise, although the rate of sustained virologic response with this agent has been disappointing. The next generation of antivirals will consist of protease and polymerase inhibitors, a number of which are undergoing investigation, initially as monotherapy and subsequently in combination with pegylated interferon and ribavirin. Challenges include the prevention of recurrent HCV infection in liver-transplant recipients and development of a safe and effective HCV vaccine.
Schiff
Eugene R
ER
University of Miami School of Medicine, 1500 NW 12 Avenue, Jackson Medical Tower E-1101, Miami, FL 33136, USA. eschiff@med.miami.edu
D000998:Antiviral Agents / Q000627:therapeutic use*; D004279:DNA, Viral; D004359:Drug Therapy, Combination; D006526:Hepatitis C / Q000188:drug therapy* / Q000517:prevention & control; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000627:therapeutic use*; D019384:Nucleic Acid Synthesis Inhibitors; D011092:Polyethylene Glycols / Q000627:therapeutic use*; D011480:Protease Inhibitors / Q000009:adverse effects / Q000627:therapeutic use; D011994:Recombinant Proteins; D012254:Ribavirin / Q000009:adverse effects / Q000031:analogs & derivatives / Q000627:therapeutic use*; D014765:Viral Vaccines / Q000009:adverse effects / Q000627:therapeutic use; D014779:Virus Replication / Q000187:drug effects
D000998:Antiviral Agents; D004279:DNA, Viral; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D019384:Nucleic Acid Synthesis Inhibitors; D011480:Protease Inhibitors; D011994:Recombinant Proteins; D014765:Viral Vaccines; D011092:Polyethylene Glycols; D012254:Ribavirin; C100416:peginterferon alfa-2a; C026956:taribavirin