[Marchiafava-Bignami disease].
Marchiafava-Bignami disease (MBD) is a rare central nervous system disorder of an unknown etiology strongly associated with alcoholism. MBD primarily affects the corpus callosum leading to confusion, dysarthria, seizures and frequently to death. About 250 cases of different races and nationalities, mostly alcoholics have been reported. We report a single-case study of a 43-year-old woman with the history of severe alcohol abuse, who demonstrated typical picture of Marchiafava-Bignami disease (MBD) with fatal course. We reviewed the literature on cases of MBD.
Kukulska-Pawluczuk
Beata
B
Z Katedry i Kliniki Neurologii, Collegium Medicum im. Ludwika Rydygiera, Bydgoszczy. bkukulska@yahoo.com
Princ
Robert
R
Burzyńska-Makuch
Malgorzata
M
Borkowska
Alina
A
D000328:Adult; D020268:Alcohol-Induced Disorders, Nervous System / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D000437:Alcoholism / Q000150:complications; D001927:Brain Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology / Q000473:pathology; D003337:Corpus Callosum / Q000473:pathology*; D003711:Demyelinating Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology / Q000473:pathology; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D019636:Neurodegenerative Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology / Q000473:pathology; D013831:Thiamine / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed
D013831:Thiamine