title: Detection of two porcine circovirus type 2 genotypic groups in United States swine herds.
abstract: In late 2005, sporadic cases of an acute onset disease of high mortality were observed in 10- to 16-week-old growing pigs among several swine herds of the United States. Tissues from the affected pigs in Kansas, Iowa, and North Carolina were examined, and porcine circovirus type 2 (PCV2) was detected consistently among these tissues. Phylogenetically, PCV2 can be divided into two major genotypic groups, PCV2-group 1 and PCV2-group 2. Whereas PCV2-group 1 isolates were detected in all the diseased animals, only two of the diseased animals harbored PCV2-group 2 isolates. This observation is important because PCV2-group 1 isolates had never been reported in the United States before (GenBank as of May 16, 2006), and they are closely related to the PCV2-group 1 isolates that have been described in Europe and Asia, previously. Our analysis revealed that each genotypic group contains a distinct stretch of nucleotide or amino acid sequence that may serve as a signature motif for PCV2-group 1 or PCV2-group 2 isolates.
authors.affiliation: Virus and Prion Diseases of Livestock Research Unit, National Animal Disease Center, USDA-Agricultural Research Service, Ames, Iowa 50010, USA. acheung@nadc.ars.usda.gov
authors.forename: A K
authors.initials: AK
authors.lastname: Cheung
authors.forename: K M
authors.initials: KM
authors.lastname: Lager
authors.forename: O I
authors.initials: OI
authors.lastname: Kohutyuk
authors.forename: A L
authors.initials: AL
authors.lastname: Vincent
authors.forename: S C
authors.initials: SC
authors.lastname: Henry
authors.forename: R B
authors.initials: RB
authors.lastname: Baker
authors.forename: R R
authors.initials: RR
authors.lastname: Rowland
authors.forename: A G
authors.initials: AG
authors.lastname: Dunham
mesh_terms: D000822:Animal Husbandry; D000818:Animals; D018173:Circoviridae Infections / Q000662:veterinary* / Q000821:virology; D017925:Circovirus / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification; D016679:Genome, Viral; D010802:Phylogeny; D013045:Species Specificity; D013552:Swine; D013553:Swine Diseases / Q000821:virology*; D014481:United States