Tyrosine phosphatases in steroidogenic cells: regulation and function.
In adrenocortical and Leydig cells PKA activation by trophic hormones increases the activity of protein tyrosine phosphatases and also induces the expression of MAP kinase phosphatase 1 (MKP-1), a dual activity protein phosphatase (serine/threonine and tyrosine). This work summarizes the knowledge on the regulation and the role played by cAMP-activated tyrosine phosphatases as well as MKP-1 in the hormonal activation of the acute and chronic phases of steroidogenesis.
Gorostizaga
Alejandra
A
Department of Biochemistry, School of Medicine, University of Buenos Aires, Paraguay 2155, 5th (C1121ABG) Buenos Aires, Argentina.
Cornejo Maciel
Fabiana
F
Brion
Laura
L
Maloberti
Paula
P
Podestá
Ernesto J
EJ
Paz
Cristina
C
D000302:Adrenal Cortex / Q000166:cytology / Q000378:metabolism*; D000818:Animals; D017868:Cyclic AMP-Dependent Protein Kinases / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D007985:Leydig Cells / Q000378:metabolism*; D008297:Male; D054645:Protein Phosphatase 1; D017027:Protein Tyrosine Phosphatases / Q000235:genetics / Q000378:metabolism*; D013256:Steroids / Q000096:biosynthesis*; D014158:Transcription, Genetic
D013256:Steroids; D017868:Cyclic AMP-Dependent Protein Kinases; D054645:Protein Phosphatase 1; D017027:Protein Tyrosine Phosphatases