title: BDNF genotype potentially modifying the association between incident stroke and depression.
abstract: OBJECTIVE
  To investigate the role of the brain-derived neurotrophic factor (BDNF) gene val66met polymorphism in the association between stroke and depression.
  
  
  METHODS
  Five hundred community residents aged >65 years without stroke or depression at baseline were re-evaluated after 2 years. Disability (World Health Organization Disability Assessment Schedule, WHODAS II), cognitive function (Mini-Mental State Examination, MMSE), and BDNF genotype were also measured at baseline.
  
  
  RESULTS
  The association between incident stroke and depression was strengthened progressively with increasing numbers of met alleles, and was only significant in subjects with the met/met genotype after adjustment for disability and cognitive function.
  
  
  CONCLUSIONS
  The BDNF val66met polymorphism may modify the association between stroke and depression.
authors.affiliation: Department of Psychiatry and Depression Clinical Research Center, Chonnam National University Medical School, Kwangju, Republic of Korea.
authors.forename: Jae-Min
authors.initials: JM
authors.lastname: Kim
authors.forename: Robert
authors.initials: R
authors.lastname: Stewart
authors.forename: Sung-Wan
authors.initials: SW
authors.lastname: Kim
authors.forename: Su-Jin
authors.initials: SJ
authors.lastname: Yang
authors.forename: Il-Seon
authors.initials: IS
authors.lastname: Shin
authors.forename: Young-Hoon
authors.initials: YH
authors.lastname: Kim
authors.forename: Jin-Sang
authors.initials: JS
authors.lastname: Yoon
mesh_terms: D000368:Aged; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics*; D015897:Comorbidity; D003863:Depression / Q000175:diagnosis / Q000453:epidemiology* / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000235:genetics; D005838:Genotype; D006801:Humans; D015994:Incidence; D007723:Korea / Q000453:epidemiology; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D020521:Stroke / Q000175:diagnosis / Q000453:epidemiology* / Q000235:genetics*
chemical_list: D019208:Brain-Derived Neurotrophic Factor