Spindle regulation in neural precursors of flies and mammals.
The mitotic spindle is the cellular scaffold that facilitates proper segregation of genetic material during cell division. Far from being static, the spindle is a dynamically regulated tool that can alter its size, shape and position during mitosis. Work in both insect and vertebrate systems has shown that regulation of this structure involves an array of highly conserved proteins. Moreover, it is now clear that tight regulation of the spindle during the process of neurogenesis is paramount to proper cell division and generation of the nervous system as a whole.
Buchman
Joshua J
JJ
Department of Brain and Cognitive Sciences, Picower Institute for Learning and Memory, RIKEN-MIT Neuroscience Research Center, Howard Hughes Medical Institute, Cambridge, Massachusetts, USA.
Tsai
Li-Huei
LH
D000818:Animals; D018797:Cell Cycle Proteins / Q000502:physiology; D004175:Diptera / Q000166:cytology; D006801:Humans; D008322:Mammals; D008954:Models, Biological; D009474:Neurons / Q000166:cytology*; D008941:Spindle Apparatus / Q000502:physiology*; D013234:Stem Cells / Q000502:physiology*
D018797:Cell Cycle Proteins