Effect of myeloablative bone marrow transplantation on growth in children with sickle cell anaemia: results of the multicenter study of haematopoietic cell transplantation for sickle cell anaemia.
Although haematopoietic cell transplantation (HCT) is curative for sickle cell anaemia (SCA), concerns about its short- and long-term toxicities limit its application. A potential toxicity is an adverse effect on growth. To identify an HCT growth effect, serial height and weight measurements from 53 children and adolescents with SCA after receiving a transplant were compared to historical controls. Hierarchical Linear Models for longitudinal data were used for analysis. In general growth was not impaired by HCT for SCA in young children; however, diminished growth may occur if HCT is carried out near or during the adolescent growth spurt.
Eggleston
B
B
Blood and Marrow Transplantation Program, Children's Hospital and Research Center, Oakland, CA 94609, USA.
Patience
M
M
Edwards
S
S
Adamkiewicz
T
T
Buchanan
G R
GR
Davies
S C
SC
Dickerhoff
R
R
Donfield
S
S
Feig
S A
SA
Giller
R H
RH
Haight
A
A
Horan
J
J
Hsu
L L
LL
Kamani
N
N
Lane
P
P
Levine
J E
JE
Margolis
D
D
Moore
T B
TB
Ohene-Frempong
K
K
Redding-Lallinger
R
R
Roberts
I A G
IA
Rogers
Z R
ZR
Sanders
J E
JE
Scott
J P
JP
Sleight
B
B
Thompson
A A
AA
Sullivan
K M
KM
Walters
M C
MC
D000367:Age Factors; D000375:Aging / Q000502:physiology; D000755:Anemia, Sickle Cell / Q000188:drug therapy / Q000503:physiopathology / Q000628:therapy*; D000986:Antisickling Agents / Q000627:therapeutic use; D001827:Body Height; D016026:Bone Marrow Transplantation / Q000009:adverse effects; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006128:Growth; D006801:Humans; D006918:Hydroxyurea / Q000627:therapeutic use; D008297:Male; D015430:Weight Gain
D000986:Antisickling Agents; D006918:Hydroxyurea