title: Tuberculous gumma associated with idiopathic thrombocytopenic purpura: report of a Japanese female patient.
abstract: Our patient was a 77-year-old Japanese woman, who was under treatment for idiopathic thrombocytopenic purpura (ITP) and chronic renal failure. She had warm nodules and cord-like induration on her left knee that appeared similar to Bazin's erythema induratum. A chest X-ray examination revealed miliary tuberculosis; after anti-mycobacterial therapy, the warm nodules and cord-like induration were transformed into a cold, non-tender abscess that drained. Histopathological findings showed caseation necrosis in the subcutaneous tissue, however, mycobacteria were directly detected by Ziehl-Neelsen staining from cutaneous lesions, and cultures from the same lesion also grew Mycobacterium tuberculosis. Tuberculous gumma demonstrated multiple, cold, painless abscesses and thrombosis were also seen. This is a rare and unusual clinical form of cutaneous tuberculosis, and the result of hematogenous dissemination from a primary focus during periods of lowered resistance.
authors.affiliation: Department of Dermatology, Kitasato University School of Medicine, Sagamihara, Kanagawa, and Daisan Hospital, Tokyo, Japan. hm4765@yahoo.co.jp
authors.forename: Hideki
authors.initials: H
authors.lastname: Maejima
authors.forename: Satoru
authors.initials: S
authors.lastname: Arai
authors.forename: Toshiya
authors.initials: T
authors.lastname: Ebata
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Takeda
authors.forename: Mai
authors.initials: M
authors.lastname: Kusunoki
authors.forename: Kensei
authors.initials: K
authors.lastname: Katsuoka
mesh_terms: D000038:Abscess / Q000382:microbiology / Q000473:pathology; D000368:Aged; D005260:Female; D006801:Humans; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000150:complications*; D014382:Tuberculosis, Cutaneous / Q000150:complications* / Q000473:pathology