Gene-gene interaction analysis of personality traits in a Japanese population using an electrochemical DNA array chip analysis.
It has been suggested that genes involved in the central dopaminergic pathway may contribute to personality traits. However, the results of association studies for these genes have not been consistent. The present study investigated the relationship between the specific polymorphisms of MAO-A, COMT, DRD2, DRD3 and personality traits in Japanese women using a novel genotyping method involving electrochemical DNA array (ECA) chip analysis. Single marker association analysis for each mutation revealed no significant association between scores for Neuroticism Extraversion Openness-Five Factor Inventory (NEO-FFI) items. Gene-gene interaction analysis showed that a MAO-A 30-bp repeatxCOMT (Val158Met)xDRD3 (Ser9Gly) had a marginally significant association with Agreeableness (P=0.0547). The present results suggest that a combination of polymorphisms of MAO-A, COMT, and DRD3 might affect personality traits in Japanese women.
Urata
Tomohiro
T
TUM Gene Inc., Chiba, Japan.
Takahashi
Nagahide
N
Hakamata
Yuko
Y
Iijima
Yoshimi
Y
Kuwahara
Natsumi
N
Ozaki
Norio
N
Ono
Yutaka
Y
Amano
Masahiko
M
Inada
Toshiya
T
D000293:Adolescent; D000328:Adult; D044466:Asian People / Q000235:genetics; D001921:Brain / Q000378:metabolism*; D001923:Brain Chemistry / Q000235:genetics*; D002394:Catechol O-Methyltransferase / Q000235:genetics; D004252:DNA Mutational Analysis; D004298:Dopamine / Q000378:metabolism*; D005260:Female; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation / Q000235:genetics*; D005819:Genetic Markers / Q000235:genetics; D005820:Genetic Testing; D006801:Humans; D007564:Japan; D008995:Monoamine Oxidase / Q000235:genetics; D009419:Nerve Tissue Proteins / Q000235:genetics*; D020411:Oligonucleotide Array Sequence Analysis; D010551:Personality / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics; D017448:Receptors, Dopamine D2 / Q000235:genetics; D050637:Receptors, Dopamine D3 / Q000235:genetics
D005819:Genetic Markers; D009419:Nerve Tissue Proteins; D017448:Receptors, Dopamine D2; D050637:Receptors, Dopamine D3; D008995:Monoamine Oxidase; D002394:Catechol O-Methyltransferase; D004298:Dopamine