title: Factors responsible for glucose intolerance in Japanese subjects with impaired fasting glucose.
abstract: Impaired fasting glucose (IFG) represents risk of development of diabetes (DM) and its complications. We investigated insulin secretion and insulin sensitivity in 403 IFG subjects divided into three levels of 2-hour postchallenge glucose (2-h PG) to clarify the factors responsible in the development of glucose intolerance in Japanese IFG. Nearly 60% of the subjects at annual medical check-up with FPG of 6.1-7.0 mmol/l at the first screening were diagnosed by 75 g oral glucose tolerance test (OGTT) to have impaired glucose tolerance (IGT; FPG <7.0 mmol/l and 7.8 mmol/l <2-h PG <11.1 mmol/l) or DM (isolated postchallenge hyperglycemia (IPH); FPG <7.0 mmol/l and 11.1 mmol/l <2-h PG level). The primary factor in the decreased glucose tolerance was a decrease in early-phase insulin, with some contribution of increasing insulin resistance. In addition, IFG/IGT and IFG/IPH subjects showed a compensatory increase in basal insulin secretion sufficient to keep FPG levels within the non-diabetic range. IFG is composed of three different categories in basal, early-phase insulin secretion, and insulin sensitivity.
authors.affiliation: Health Informatics Research Group, Translational Research Informatics Center, Foundation for Biomedical Research and Innovation, Kobe, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Izuka
authors.forename: M
authors.initials: M
authors.lastname: Fukushima
authors.forename: A
authors.initials: A
authors.lastname: Taniguchi
authors.forename: Y
authors.initials: Y
authors.lastname: Nakai
authors.forename: H
authors.initials: H
authors.lastname: Suzuki
authors.forename: T
authors.initials: T
authors.lastname: Kawakita
authors.forename: S
authors.initials: S
authors.lastname: Kawamata
authors.forename: O
authors.initials: O
authors.lastname: Kajimoto
authors.forename: K
authors.initials: K
authors.lastname: Tsuda
authors.forename: N
authors.initials: N
authors.lastname: Nagaki
authors.forename: M
authors.initials: M
authors.lastname: Murakami
authors.forename: Y
authors.initials: Y
authors.lastname: Seino
mesh_terms: D044466:Asian People; D001786:Blood Glucose / Q000032:analysis; D005215:Fasting / Q000097:blood; D018149:Glucose Intolerance / Q000209:etiology*; D005951:Glucose Tolerance Test; D006801:Humans; D006943:Hyperglycemia / Q000097:blood*; D007328:Insulin / Q000378:metabolism; D007333:Insulin Resistance; D000078790:Insulin Secretion; D008875:Middle Aged
chemical_list: D001786:Blood Glucose; D007328:Insulin