[Allopurinol-induced chronic granulomatous interstitial nephritis].
Although drug induced interstitial nephritis is a relatively common cause of renal failure,granulomatous forms remain a rare condition. The development of a chronic granulomatous interstitial nephritis due to allopurinol is exceptional, only three cases have been described previously. We report on a patient who presented a granulomatous interstitial nephritis after 10 years of allopurinol administration (300 mg/day). At diagnosis, he had end stage renal disease and dialysis treatment was needed. Two months after drug withdrawal and on corticoid treatment a slow recovery of renal function was observed, allowing the interruption of dialysis. Two years after, the creatinine clearance is 23 ml/min,being dialysis free. We discuss the differential diagnosis of granulomatous interstitial nephritis and its rare association with allopurinol treatment.
Almirall
J
J
Servicio de Nefrología, Corporació Sanitaria Parc Tauli, Institut Universitari Parc Tauli/UAB, Parc Tauli s/n, 08208 Sabadell, Barcelona. jalmirall@cspt.es
Orellana
R
R
Martínez Ocaña
J C
JC
Esteve
V
V
Andreu
X
X
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000368:Aged; D000493:Allopurinol / Q000009:adverse effects* / Q000627:therapeutic use; D002908:Chronic Disease; D003404:Creatinine / Q000097:blood; D003937:Diagnosis, Differential; D006099:Granuloma / Q000139:chemically induced* / Q000175:diagnosis; D006801:Humans; D033461:Hyperuricemia / Q000188:drug therapy; D007676:Kidney Failure, Chronic / Q000209:etiology; D008297:Male; D009395:Nephritis, Interstitial / Q000139:chemically induced* / Q000150:complications / Q000188:drug therapy; D006435:Renal Dialysis; D012507:Sarcoidosis / Q000175:diagnosis
D000305:Adrenal Cortex Hormones; D000493:Allopurinol; D003404:Creatinine