title: [Epigenetic changes and liver carcinogenesis].
abstract: The molecular mechanisms involved in liver carcinogenesis are poorly understood. Over the past decade, epigenetic changes (DNA methylation) have received increasing attention for their potential involvement in the development of hepatocarcinoma. The DNA methylation level is influenced by environmental factors (folate and methionine diet), as well as by genetic factors (methylenetetrahydrofolate reductase/MTHFR polymorphisms). These findings provide new insight into the understanding of liver carcinogenesis. Interventional studies are now required to determine the role of folate supplementation in the development of liver tumors in targeted patients.
authors.affiliation: Service d'Hépato-Gastroentérologie et Laboratoire de Pathologie Cellulaire et Moléculaire en Nutrition-INSERM U724, CHU Nancy, Vandoeuvre-les-Nancy. peyrin-biroulet@netcourrier.com
authors.forename: Laurent
authors.initials: L
authors.lastname: Peyrin-Biroulet
authors.forename: Hélène
authors.initials: H
authors.lastname: Barraud
authors.forename: Fabien
authors.initials: F
authors.lastname: Darfeuil
authors.forename: Mathieu
authors.initials: M
authors.lastname: Lefebvre
authors.forename: Marc-André
authors.initials: MA
authors.lastname: Bigard
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Gueant
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Bronowicki
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000235:genetics*; D019175:DNA Methylation; D044127:Epigenesis, Genetic; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics*; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics; D011110:Polymorphism, Genetic
chemical_list: D042965:Methylenetetrahydrofolate Reductase (NADPH2)