CuBr/rac-BINOL-catalyzed N-arylations of aliphatic amines at room temperature.
We have developed an efficient and readily available catalyst system CuBr/racemic BINOL (1,1'-binaphthyl-2,2'-diol) that catalyzes N-arylation of aliphatic amines at room temperature, and this inexpensive catalyst system is of high selectivity and tolerance toward various functional groups in the substrates.
Jiang
Deshou
D
Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology, Ministry of Education, Department of Chemistry, Tsinghua University, Beijing 100084, P. R. China.
Fu
Hua
H
Jiang
Yuyang
Y
Zhao
Yufen
Y
D000478:Alkylation; D000588:Amines / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D003300:Copper / Q000737:chemistry; D015394:Molecular Structure; D009281:Naphthalenes / Q000737:chemistry*; D013237:Stereoisomerism; D013696:Temperature
D000588:Amines; D009281:Naphthalenes; C475744:S(-)2,2'-dihydroxy-1,1'-binaphthyl; C042514:cuprous ion; D003300:Copper