Chemokines CXCL10 and CXCL11 in the cerebrospinal fluid of patients with tick-borne encephalitis.
OBJECTIVE
The aim of our study was to determine whether cerebrospinal fluid (CSF) of patients with tick-borne encephalitis (TBE) contains CXCL10, CXCL11, p40 subunit of interleukin-12 (IL-12)/IL-23, IL-18 and IL-15. We compared serum and CSF concentrations of CXCL10 and analysed the possible concentration gradient of this chemokine between the periphery and central nervous system.


METHODS
The study enrolled 19 TBE patients and 10 patients with non-inflammatory neurological diseases.


RESULTS
CSF of TBE patients contained CXCL10 (median 217 pg/ml), CXCL11 (8.3 pg/ml), p40 subunit of IL-12/IL-23 (38.9 pg/ml), IL-18 (30.1 pg/ml) and IL-15 (5.9 pg/ml). CXCL10 in the CSF of TBE patients was higher compared with serum (median 62 pg/ml, P < 0.001).


CONCLUSIONS
CSF of TBE patients contains CXCL10, CXCL11, p40 subunit of IL-12/IL-23, IL-18 and IL-15. Increased CXCL10 concentration in CSF suggests a role for this chemokine in the recruitment of CXCR3-expressing T-cells into the CSF of TBE patients.
Lepej
S Z
SZ
University Hospital for Infectious Diseases Dr Fran Mihaljević, Zagreb, Croatia. snjezana.zidovec.lepej@bfm.hr
Misić-Majerus
L
L
Jeren
T
T
Rode
O D
OD
Remenar
A
A
Sporec
V
V
Vince
A
A
D000328:Adult; D000914:Antibodies, Viral / Q000097:blood; D016022:Case-Control Studies; D054357:Chemokine CXCL10; D054371:Chemokine CXCL11; D019743:Chemokines, CXC / Q000097:blood / Q000134:cerebrospinal fluid*; D003430:Cross-Sectional Studies; D004669:Encephalitis Viruses, Tick-Borne / Q000276:immunology; D004675:Encephalitis, Tick-Borne / Q000097:blood / Q000134:cerebrospinal fluid*; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D007378:Interleukins / Q000097:blood / Q000134:cerebrospinal fluid*; D008297:Male; D008875:Middle Aged
D000914:Antibodies, Viral; C114753:CXCL10 protein, human; C515202:CXCL11 protein, human; D054357:Chemokine CXCL10; D054371:Chemokine CXCL11; D019743:Chemokines, CXC; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007378:Interleukins