Sertoli-Leydig cell tumours of the ovary and testis: a CGH and FISH study.
We present two malignant cases of Sertoli-Leydig cell tumours (SLCT) of the testis and one ovarian SLCT with benign behaviour. The DNA copy number changes affected chromosome 1, 8, 9p, 10, 11, 12, 16, 19, 22 and X. The present study is the first molecular-cytogenetic analysis of Sertoli-Leydig cell tumours of the testis.
Verdorfer
I
I
Institute of Pathology, Medical University of Innsbruck, Muellerstrasse 44, 6020, Innsbruck, Austria. Irmgard.Verdorfer@i-med.ac.at
Horst
D
D
Höllrigl
A
A
Rogatsch
H
H
Mikuz
G
G
D000368:Aged; D002869:Chromosome Aberrations; D005260:Female; D018628:Gene Dosage; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D008297:Male; D010051:Ovarian Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D018310:Sertoli-Leydig Cell Tumor / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D013736:Testicular Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology