title: [Case of ulcerative colitis associated with drug-induced hypersensitivity syndrome (DIHS) by salazosulfapyridine].
abstract: We experienced a case of drug-induced hypersensitivity syndrome (DIHS) for salazosulfapyridine (SASP). After we started administration of SASP in a 26-year old man with ulcerative colitis (UC), he had symptoms resembling infectious mononucleosis, high fever, skin eruption, cervical lymphadenopathy, elevate white blood cell count with atypical lymphocyte, and liver dysfunction. We diagnosed the illness as drug-induced hypersensitivity syndrome (DIHS) due to SASP. We halted SASP and started administration of methylprednisolone and prednisolone but his condition deteriorated. We changed to administration of betamethasone and he recovered. In cases of DIHS accompanied by UC, we should administer drugs carefully and recognize serious complications.
authors.affiliation: Department of Gastroenterology, Saiseikai Suita Hospital, and Department of Internal Medicine, Shiga University of Medical Science, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Nishimura
authors.forename: Hirozumi
authors.initials: H
authors.lastname: Obata
authors.forename: Hiroko
authors.initials: H
authors.lastname: Fujino
authors.forename: Ayano
authors.initials: A
authors.lastname: Sonoda
authors.forename: Kenichiro
authors.initials: K
authors.lastname: Sakamoto
authors.forename: Chiemi
authors.initials: C
authors.lastname: Mizuno
authors.forename: Masayuki
authors.initials: M
authors.lastname: Mizuno
authors.forename: Toshihide
authors.initials: T
authors.lastname: Shima
authors.forename: Shinobu
authors.initials: S
authors.lastname: Nakajyo
authors.forename: Yoshihide
authors.initials: Y
authors.lastname: Fujiyama
mesh_terms: D000328:Adult; D001623:Betamethasone / Q000627:therapeutic use*; D003093:Colitis, Ulcerative / Q000150:complications* / Q000188:drug therapy*; D004342:Drug Hypersensitivity / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology*; D006801:Humans; D008297:Male; D008775:Methylprednisolone / Q000009:adverse effects; D011239:Prednisolone / Q000009:adverse effects; D012460:Sulfasalazine / Q000009:adverse effects*; D013577:Syndrome; D016896:Treatment Outcome
chemical_list: D012460:Sulfasalazine; D001623:Betamethasone; D011239:Prednisolone; D008775:Methylprednisolone