Psoriasis: a possible risk factor for development of coronary artery calcification.
BACKGROUND
Psoriasis is a chronic inflammatory skin disorder affecting about 2% of white-skinned individuals. Epidemiological data on the prevalence and degree of coronary artery calcification (CAC) as an indicator for cardiovascular diseases in patients with psoriasis are contradictory.


OBJECTIVE
To study the prevalence and degree of CAC as an indicator for cardiovascular diseases in 32 patients with psoriasis matched for age, sex and risk factors to an equally sized control population.


METHODS
Noncontrast-enhanced 16-row spiral computed tomography was performed in patients and controls.


RESULTS
We found a significantly increased prevalence (59.4% vs. 28.1%, P = 0.015) and severity (CAC score according to Agatston 3.7 vs. 0.0, P = 0.019) of CAC in patients with psoriasis. Multiple linear regression calculations identified psoriasis as a likely independent risk factor for CAC.


CONCLUSIONS
Our results point towards the potentially systemic nature of the inflammatory processes underlying the pathogenesis of psoriasis, which may therefore be considered a potentially severe systemic disease.
Ludwig
R J
RJ
Department of Dermatology and Department of Radiology, Johann Wolfgang Goethe-University, Theodor-Stern-Kai 7, D-60590 Frankfurt am Main, Germany.
Herzog
C
C
Rostock
A
A
Ochsendorf
F R
FR
Zollner
T M
TM
Thaci
D
D
Kaufmann
R
R
Vogl
T J
TJ
Boehncke
W-H
WH
D000328:Adult; D000368:Aged; D002114:Calcinosis / Q000209:etiology*; D016022:Case-Control Studies; D015331:Cohort Studies; D003327:Coronary Disease / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000150:complications*; D012307:Risk Factors; D012720:Severity of Illness Index; D014057:Tomography, X-Ray Computed