title: Sentinel lymph node mapping in colon cancer: current status.
abstract: BACKGROUND
  The primary role of sentinel lymph node (SLN) mapping in colon cancer is to increase the accuracy of nodal staging by identifying those lymph nodes with the greatest potential for harbouring metastatic disease. Ultrastaging techniques aim to identify the otherwise undetected metastases. Until now, no consensus exists as to the most optimal procedure in patients with colon cancer.
  
  
  METHODS
  A systematic literature search on the value of different SLN mapping techniques in patients with colon cancer was performed using the electronic search engine PubMed. Prospective studies published before 1 December 2005 were included and further articles were selected by cross-referencing. The results of different techniques using either blue dye or radiocolloid, were investigated.
  
  
  RESULTS
  The literature search yielded 17 relevant articles. SLN mapping using blue dye was described in 15 studies. Two studies reported the results of SLN mapping using a combination of blue dye and radiocolloid. The reported results on identification rate varied between 71 and 100%. Accuracy rates were between 78 and 100%, sensitivity rates between 25 and 100% and true upstaging rates between 0 and 26%. The results were not affected by the addition of radiocolloid to blue dye.
  
  
  CONCLUSIONS
  Sentinel lymph node mapping in patients with colon cancer remains an experimental procedure with varying results. Further evaluation may lead to a standardized technique that offers the potential for significant upstaging of stage II patients. This may have important implications as to tailor adjuvant chemotherapeutic regimens in these patients.
authors.affiliation: Department of Surgery, University Medical Center Utrecht, P.O. Box 85500, 3508, GA, Utrecht, The Netherlands.
authors.forename: Robbert J
authors.initials: RJ
authors.lastname: de Haas
authors.forename: Dennis A
authors.initials: DA
authors.lastname: Wicherts
authors.forename: Monique G G
authors.initials: MG
authors.lastname: Hobbelink
authors.forename: Inne H M
authors.initials: IH
authors.lastname: Borel Rinkes
authors.forename: Marguerite E I
authors.initials: ME
authors.lastname: Schipper
authors.forename: Joke-Afke
authors.initials: JA
authors.lastname: van der Zee
authors.forename: Richard
authors.initials: R
authors.lastname: van Hillegersberg
mesh_terms: D003110:Colonic Neoplasms / Q000473:pathology*; D005629:Frozen Sections; D006801:Humans; D008197:Lymph Node Excision; D008198:Lymph Nodes / Q000473:pathology*; D008207:Lymphatic Metastasis; D009361:Neoplasm Invasiveness / Q000175:diagnosis; D009367:Neoplasm Staging; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D021701:Sentinel Lymph Node Biopsy