Dynamic genome architecture in the nuclear space: regulation of gene expression in three dimensions.
The regulation of gene expression is mediated by interactions between chromatin and protein complexes. The importance of where and when these interactions take place in the nucleus is currently a subject of intense investigation. Increasing evidence indicates that gene activation or silencing is often associated with repositioning of the locus relative to nuclear compartments and other genomic loci. At the same time, however, structural constraints impose limits on chromatin mobility. Understanding how the dynamic nature of the positioning of genetic material in the nuclear space and the higher-order architecture of the nucleus are integrated is therefore essential to our overall understanding of gene regulation.
Lanctôt
Christian
C
Department Biologie II, Ludwig-Maximilians Universität, Grosshadernerstr. 2, Planegg-Martinsried, Germany. christian.lanctot@lrz.uni-muenchen.de
Cheutin
Thierry
T
Cremer
Marion
M
Cavalli
Giacomo
G
Cremer
Thomas
T
D001692:Biological Transport / Q000502:physiology; D002467:Cell Nucleus / Q000235:genetics* / Q000502:physiology; D002843:Chromatin / Q000235:genetics* / Q000378:metabolism / Q000502:physiology; D005786:Gene Expression Regulation; D016678:Genome / Q000235:genetics*; D046228:Microarray Analysis / Q000379:methods; D008957:Models, Genetic; D009687:Nuclear Proteins / Q000235:genetics* / Q000378:metabolism / Q000502:physiology; D013997:Time Factors; D015533:Transcriptional Activation
D002843:Chromatin; D009687:Nuclear Proteins