title: [Study on the preparation and quality standard of Ephedra sinica dispensing granules].
abstract: OBJECTIVE
  To optimize the preparation process and to set up the quality standard of Ephedra sinica Dispensing Granules.
  
  
  METHODS
  Nine experiments were carried out by L9 (3(4)) orthogonal design. Ephedra sinica Dispensing Granules was identified by TLC and the content of ephedrine was determined by HPLC.
  
  
  RESULTS
  The optimal extraction process was as follows: the water that 10 times of Ephedra sinica, was decocted 3 times and each time was sustained for 1.5 hours. The linear relationship of ephedrine hydrochloride was at the range of 0.0081 - 0.1377 microg (r = 0.999 9). The average recovery was 100.25% ( RSD = 2.24%, n = 6).
  
  
  CONCLUSIONS
  The extraction process is scientific. The method is available with a good reproducibility and can control the quality of Ephedra sinica Dispensing Granules.
authors.affiliation: School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China. super_zhou@eyou.com
authors.forename: Bin
authors.initials: B
authors.lastname: Zhou
authors.forename: Wen-Yuan
authors.initials: WY
authors.lastname: Gao
authors.forename: Tie-Jun
authors.initials: TJ
authors.lastname: Zhang
authors.forename: Jia-Xin
authors.initials: JX
authors.lastname: Zhang
mesh_terms: D002851:Chromatography, High Pressure Liquid / Q000379:methods; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification / Q000592:standards*; D029790:Ephedra sinica / Q000737:chemistry*; D004809:Ephedrine / Q000032:analysis* / Q000302:isolation & purification; D006358:Hot Temperature; D010946:Plants, Medicinal / Q000737:chemistry*; D011786:Quality Control; D015203:Reproducibility of Results; D013678:Technology, Pharmaceutical / Q000379:methods; D013995:Time; D014867:Water / Q000008:administration & dosage
chemical_list: D004365:Drugs, Chinese Herbal; D014867:Water; D004809:Ephedrine