title: Mass spectroscopic characterisation of oligomeric proanthocyanidins derived from an extract of Pelargonium sidoides roots (EPs 7630) and pharmacological screening in CNS models.
abstract: Chromatographic fractionation of proanthocyanidin oligomers from an aqueous ethanolic extract of Pelargonium sidoides roots (EPs 7630) gave a diverse set of epigallo- and gallocatechin based oligomers, which are connected by A and B-type bonds. Additionally, two series of monosubstituted oligomers were detected by mass spectroscopy, sulphates and aminoconjugates. In vivo studies investigating motility, body weight gain, body temperature, motoric coordination, anticonvulsant effects and central analgesic activities, showed no or only moderate pharmacological effects, indicating, that they have no intrinsic behavioural activities.
authors.affiliation: Department of Preclinical Research, Dr. Willmar Schwabe GmbH & Co. KG, 76227 Karlsruhe, Germany. karl.schoetz@schwabe.de <karl.schoetz@schwabe.de>
authors.forename: Karl
authors.initials: K
authors.lastname: Schötz
authors.forename: Michael
authors.initials: M
authors.lastname: Nöldner
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D002490:Central Nervous System / Q000187:drug effects*; D008297:Male; D013058:Mass Spectrometry; D051379:Mice; D031316:Pelargonium; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D018517:Plant Roots; D044945:Proanthocyanidins / Q000737:chemistry
chemical_list: C476332:EPs 7630; D010936:Plant Extracts; D044945:Proanthocyanidins; C013221:proanthocyanidin