A multicenter study of the pharmacokinetics of lisinopril in pediatric patients with hypertension.
The pharmacokinetic (PK) parameters of lisinopril were obtained in 46 children aged 6 months to 15 years. A lisinopril suspension (0.15 mg/kg per day) was administered to patients <6 years of age; the remaining children received lisinopril tablets, the daily dose being adjusted according to body weight, i.e., 2.5 mg if <25 kg, 5 mg if 25-45 kg, and 10 mg if >45 kg. Blood was drawn predose and on eight occasions postdose in children aged 4-15 years, and on five occasions in those aged <4 years. PK data are reported for the 46 children in terms of age groups: Group I (n=9), aged 6-23 months; Group II (n=8), aged 2-5 years; Group III (n=12), aged 6-11 years; Group IV (n=17), aged 12-15 years. The dose of lisinopril ranged from 3.07 mg/m(2) per day in Group I to 4.78 mg/m(2) per day in Group IV. C(max) of lisinopril, which occurred 5-6 h postdose, varied from 22 ng/ml in Groups I and II to 44 ng/ml in Groups III and IV; AUC(0-24 h) ranged from 301-311 ng.h/ml in Groups I and II to 550-570 ng.h/ml in Groups III and IV. No serious adverse events related to lisinopril were reported.
Hogg
Ronald J
RJ
St. Joseph's Hospital and Medical Center, 222 W. Thomas Rd., Suite 410, Phoenix, AZ 85013, USA. Ronald.Hogg@chw.edu
Delucchi
Angela
A
Sakihara
Graciela
G
Wells
Thomas G
TG
Tenney
Frank
F
Batisky
Donald L
DL
Blumer
Jeffrey L
JL
Vogt
Beth A
BA
Lo
Man-Wai
MW
Hand
Elizabeth
E
Panebianco
Deborah
D
Rippley
Ronda
R
Shaw
Wayne
W
Shahinfar
Shahnaz
S
D000293:Adolescent; D000959:Antihypertensive Agents / Q000097:blood / Q000493:pharmacokinetics / Q000627:therapeutic use; D001800:Blood Specimen Collection; D002648:Child; D002675:Child, Preschool; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D007223:Infant; D017706:Lisinopril / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use; D008297:Male; D008657:Metabolic Clearance Rate
D000959:Antihypertensive Agents; D017706:Lisinopril