[Heparin-induced thrombocytopenia in hemodialysis. Case report and review of the literature].
Thrombocytopenia is a potential complication of heparin therapy. There are two forms of heparin-induced thrombocytopenia (HIT). Type-I HIT is characterized by a mild decrease in platelet count that occurs within the first 2-4 days after heparin initiation. The platelet count often returns to normal without stop heparin treatment. The mechanism of thrombocytopenia appears to be due to a direct effect of heparin on platelet activation. The second form (type-II) is an immune-mediated disorder characterized by severe thrombocytopenia, which may include both arterial and venous thrombosis. We present a case of type-II HIT occurred in a hemodialysis patient resulting in acute pulmonary embolism and peripheral venous thrombosis, and review the literature.
Henríquez
F
F
Servicio de Nefrología, Hospital Universitario Nuestra Señora de Candelaria, Carreteral del Rosario 145.
Rodríguez
A
A
Mora
C
C
Sánchez-Deig
E
E
Macía
M
M
Navarro
J
J
D000465:Algorithms; D000925:Anticoagulants / Q000009:adverse effects* / Q000494:pharmacology / Q000627:therapeutic use; D019468:Disease Management; D005268:Femoral Vein; D006493:Heparin / Q000009:adverse effects* / Q000494:pharmacology / Q000627:therapeutic use; D006495:Heparin, Low-Molecular-Weight / Q000627:therapeutic use; D024764:Hirudin Therapy; D006801:Humans; D006973:Hypertension / Q000150:complications; D007676:Kidney Failure, Chronic / Q000150:complications / Q000628:therapy; D008297:Male; D008875:Middle Aged; D015539:Platelet Activation / Q000187:drug effects; D010976:Platelet Count; D011655:Pulmonary Embolism / Q000188:drug therapy / Q000209:etiology*; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000139:chemically induced*; D006435:Renal Dialysis; D013921:Thrombocytopenia / Q000139:chemically induced* / Q000145:classification; D013924:Thrombophlebitis / Q000188:drug therapy / Q000209:etiology; D013927:Thrombosis / Q000188:drug therapy / Q000209:etiology / Q000517:prevention & control
D000925:Anticoagulants; D006495:Heparin, Low-Molecular-Weight; D006493:Heparin