Effects of catecholamines on blood pressure in the femoral bone marrow cavity in ovariectomized rats.
Menopausal women display changes in the osseous tissue (osteoporosis, pathologic fractures) and disorders in the function of cardiovascular system (hypertension, cardiovascular disease, arteriosclerosis, calcification). Additionally, interdependence was observed between the loss of osseous tissue and disordered circulation, but the mechanism of the interdependence has never been fully recognized. In order to clarify this problem, the present study concentrated on the effects of catecholamines on blood pressure in the femoral bone marrow cavity in ovariectomized rats. The Ficat-Arlet method was used to examine blood pressure in marrow cavity. Norepinephrine, epinephrine, isoprenaline as well as adrenoceptor antagonists (phentolamine and propranolol) were administered to the controls and the ovariectomized rats. The examinations demonstrated that ovariectomized rats displayed decreased blood pressure in the marrow cavity. In addition, an intensified effect of catecholamines on blood pressure in the marrow cavity of osteoporotic bone in ovariectomized rats was observed.
Kaczmarczyk-Sedlak
Ilona
I
Department of Pharmacology, Medical University of Silesia, Jagiellońska 4, PL 41-200 Sosnowiec, Poland. farmak@slam.katowice.pl
Cegieła
Urszula
U
Nowińska
Barbara
B
Pytlik
Maria
M
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D001853:Bone Marrow / Q000098:blood supply / Q000187:drug effects*; D002339:Carotid Arteries / Q000187:drug effects; D002395:Catecholamines / Q000494:pharmacology*; D005260:Female; D005269:Femur / Q000098:blood supply*; D007545:Isoproterenol / Q000494:pharmacology; D009638:Norepinephrine / Q000494:pharmacology; D010024:Osteoporosis / Q000503:physiopathology*; D010052:Ovariectomy; D010646:Phentolamine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar
D002395:Catecholamines; D011433:Propranolol; D007545:Isoproterenol; D009638:Norepinephrine; D010646:Phentolamine