Genomic profiling of hormone-naïve lymph node metastases in patients with prostate cancer.
The progression of organ-confined prostate cancer to metastatic cancer is inevitably fatal. Consequently, identification of structural changes in the genome and associated transcriptional responses that drive this progression is critical to understanding the disease process and the development of biomarkers and therapeutic targets. In this study, whole genome copy number changes in genomes of hormone-naïve lymph node metastases were profiled using array comparative genomic hybridization, and matched primaries were included for a subset. Matched primaries and lymph node metastases showed very similar copy number profiles that are distinct from primary tumors that fail to metastasize.
Paris
Pamela L
PL
Department of Urology, University of California at San Francisco Comprehensive Cancer Center, San Francisco, CA 94115, USA.
Hofer
Matthias D
MD
Albo
Giancarlo
G
Kuefer
Rainer
R
Gschwend
Juergen E
JE
Hautmann
Richard E
RE
Fridyland
Jane
J
Simko
Jeffrey
J
Carroll
Peter R
PR
Rubin
Mark A
MA
Collins
Colin
C
D014408:Biomarkers, Tumor / Q000235:genetics; D020869:Gene Expression Profiling / Q000379:methods*; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics*; D006801:Humans; D008207:Lymphatic Metastasis / Q000235:genetics*; D008297:Male; D011471:Prostatic Neoplasms / Q000235:genetics*
D014408:Biomarkers, Tumor