title: Occlusal disharmony induces spatial memory impairment and hippocampal neuron degeneration via stress in SAMP8 mice.
abstract: We examined the effect of occlusal disharmony in senescence-accelerated (SAMP8) mice on plasma corticosterone levels, hippocampal neuron number, and spatial performance in the water maze. The bite-raised condition was associated with an accelerated age-related decline in spatial memory, increased plasma corticosterone levels, and a decreased number of neurons in the hippocampal CA3 region. The findings suggest that the bite-raised condition in aged SAMP8 mice induces hippocampal neuron loss, thereby leading to senile memory deficits.
authors.affiliation: Department of Oral Anatomy, Division of Oral Structure, Function and Development, Asahi University School of Dentistry, 1851 Hozumi, Mizuho, Gifu 501-0296, Japan. kubo@dent.asahi-u.ac.jp
authors.forename: Kin-ya
authors.initials: KY
authors.lastname: Kubo
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Yamada
authors.forename: Mitsuo
authors.initials: M
authors.lastname: Iinuma
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Iwaku
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Tamura
authors.forename: Kazuko
authors.initials: K
authors.lastname: Watanabe
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Nakamura
authors.forename: Minoru
authors.initials: M
authors.lastname: Onozuka
mesh_terms: D000375:Aging / Q000502:physiology / Q000523:psychology; D000818:Animals; D002452:Cell Count; D016923:Cell Death / Q000502:physiology; D003345:Corticosterone / Q000097:blood; D006624:Hippocampus / Q000473:pathology / Q000503:physiopathology*; D008297:Male; D008310:Malocclusion / Q000150:complications* / Q000503:physiopathology / Q000523:psychology; D018782:Maze Learning / Q000502:physiology; D008569:Memory Disorders / Q000209:etiology* / Q000503:physiopathology / Q000523:psychology; D051379:Mice; D008817:Mice, Mutant Strains; D009410:Nerve Degeneration / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D013315:Stress, Psychological / Q000150:complications* / Q000503:physiopathology; D013705:Temporomandibular Joint Disorders / Q000150:complications / Q000503:physiopathology / Q000523:psychology; D015854:Up-Regulation / Q000502:physiology
chemical_list: D003345:Corticosterone