title: In vitro activity of aurein 1.2 alone and in combination with antibiotics against gram-positive nosocomial cocci.
abstract: This study was performed to evaluate the in vitro activity of the amphibian peptide aurein 1.2 and to investigate its interaction with six antibiotics against nosocomial gram-positive cocci. All isolates were inhibited at concentrations of 1 to 16 mg/liter. Synergy was demonstrated when aurein 1.2 was combined with clarithromycin and minocycline.
authors.affiliation: Institute of Infectious Diseases and Public Health, Università Politecnica delle Marche, c/o Ospedale Regionale, via Conca, 71, Ancona, I-60020, Italy. anconacmi@interfree.it
authors.forename: Andrea
authors.initials: A
authors.lastname: Giacometti
authors.forename: Oscar
authors.initials: O
authors.lastname: Cirioni
authors.forename: Alessandra
authors.initials: A
authors.lastname: Riva
authors.forename: Wojciech
authors.initials: W
authors.lastname: Kamysz
authors.forename: Carmela
authors.initials: C
authors.lastname: Silvestri
authors.forename: Piotr
authors.initials: P
authors.lastname: Nadolski
authors.forename: Agnese
authors.initials: A
authors.lastname: Della Vittoria
authors.forename: Jerzy
authors.initials: J
authors.lastname: Łukasiak
authors.forename: Giorgio
authors.initials: G
authors.lastname: Scalise
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D023181:Antimicrobial Cationic Peptides / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use; D003428:Cross Infection / Q000188:drug therapy; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D006095:Gram-Positive Cocci / Q000187:drug effects* / Q000378:metabolism; D008826:Microbial Sensitivity Tests
chemical_list: D000900:Anti-Bacterial Agents; D023181:Antimicrobial Cationic Peptides; C506635:aurein 1.2 peptide