title: Highly efficient synthesis of enantiomerically enriched 2-hydroxymethylaziridines by enzymatic desymmetrization.
abstract: Both enantiomers of protected and unprotected 2-hydroxymethylaziridines are efficiently and enantiospecifically synthesized by using a combination of enzymatic and synthetic methods. PPL was used for lipase-catalyzed desymmetrization of N-protected serinol. [reaction: see text].
authors.affiliation: Department of Medicinal Chemistry and Molecular Phamacology, Purdue University, West Lafayette, Indiana 47907, USA.
authors.forename: Jun Young
authors.initials: JY
authors.lastname: Choi
authors.forename: Richard F
authors.initials: RF
authors.lastname: Borch
mesh_terms: D000818:Animals; D001388:Aziridines / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D008049:Lipase / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D010179:Pancreas / Q000201:enzymology; D012680:Sensitivity and Specificity; D013237:Stereoisomerism; D013552:Swine
chemical_list: D001388:Aziridines; D008049:Lipase