title: [Neonatal treatment effect with selective inhibitor of 5-HT recapture on [corrected] the cranium-encephalic anatomic development].
abstract: Neonatal repercussion researched of the serotonin selective recapture inibitor (SSRI) chronic treatment about the somatic growth, of the encephalon and skull. Male rats were divided into groups: control (NaCl) and Cit (10 microL/Kg citalopram 10 mg). In 21 post birth days were measured body weight, side axle , front and rear and skull circle. At 8, 15, 22 days after birth, animals were sacrified for the encephalon withdrawal to evaluate the measurements mentioned above. SSRI use caused body growth deficit, skull and encephalon reduction. The retard is possibly caused by the magnitude change of the trophic serotonin action over the skull-facial morphogenesis, reinforcing the serotoninergic system participation over the somatic and ontogenic growth. The SSRI possible hypophagic effects are not discarded.
authors.affiliation: Universidade Federal de Pernambuco, Recife, PE, Brasil.
authors.forename: Carolina Peixoto
authors.initials: CP
authors.lastname: Magalhães
authors.forename: Luciene Oliveira
authors.initials: LO
authors.lastname: de Lima
authors.forename: Matilde Cesiana
authors.initials: MC
authors.lastname: da Silva
authors.forename: Sônia Maria Oliveira Cavalcanti
authors.initials: SM
authors.lastname: Marinho
authors.forename: Elizabeth
authors.initials: E
authors.lastname: do Nascimento
authors.forename: Cristiano Mendes
authors.initials: CM
authors.lastname: da Silva
authors.forename: Sandra Lopes
authors.initials: SL
authors.lastname: de Souza
authors.forename: Raul
authors.initials: R
authors.lastname: Manhães-de-Castro
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000187:drug effects / Q000254:growth & development*; D015283:Citalopram / Q000494:pharmacology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D017367:Selective Serotonin Reuptake Inhibitors / Q000494:pharmacology*; D012886:Skull / Q000187:drug effects / Q000254:growth & development*
chemical_list: D015283:Citalopram; D017367:Selective Serotonin Reuptake Inhibitors