Black tea ameliorates aflatoxin-induced lipid peroxidation in the kidney of mice.
Oral administration of 25 and 50 mg of aflatoxin in 0.2 mL olive oil/animal/day for 30 days caused dose-dependent and significantly higher lipid peroxidation in the kidney of aflatoxin-treated mice than in the controls. The levels of non-enzymatic antioxidant such as glutathione as well as the enzymatic antioxidants such as superoxide dismutase, glutathione peroxidase and catalase were significantly lower in the kidney of aflatoxin-treated mice than in the controls. Black tea extract (2%) treatment significantly ameliorates aflatoxin-induced lipid peroxidation, which could be due to higher enzymatic and non-enzymatic antioxidants in the kidney of mice as compared with that given aflatoxin alone. These findings suggest that black tea extract treatment significantly ameliorates aflatoxin-induced lipid peroxidation in the kidney of mice.
Choudhary
Anamika
A
Department of Zoology, University School of Sciences, Gujarat University, Ahmedabad 380 009, India.
Verma
Ramtej Jayram
RJ
D000348:Aflatoxins / Q000096:biosynthesis / Q000633:toxicity*; D000818:Animals; D001230:Aspergillus / Q000235:genetics; D002855:Chromatography, Thin Layer; D007668:Kidney / Q000187:drug effects / Q000378:metabolism*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D051379:Mice; D013662:Tea / Q000737:chemistry*
D000348:Aflatoxins; D013662:Tea