Intramyometrial injection of vasopressin causes bradycardia and cardiac arrest--report of two cases.
Vasopressin has been documented to effectively reduce blood loss in gynecologic practice. However, local infiltration of vasopressin may cause lethal cardiopulmonary complications in spite of rarity of reported cases. Severe bradycardia and cardiac arrest were encountered after intramyometrial injection of vasopressin in our two healthy patients undergoing open uterine myomectomy. We herewith discuss the associated complications and the anesthetic considerations.
Hung
Ming-Hsiang
MH
Department of Anesthesiology, Kaohsiung Veterans General Hospital, School of Medicine, National Yang-Ming University, Taiwan, ROC. mhhung@vghks.gov.tw
Wang
Ying-Ming
YM
Chia
Yuan-Yi
YY
Chou
Yu-Mei
YM
Liu
Kang
K
D000328:Adult; D017704:Baroreflex / Q000187:drug effects; D001919:Bradycardia / Q000139:chemically induced*; D005260:Female; D006323:Heart Arrest / Q000139:chemically induced*; D006490:Hemostatics / Q000009:adverse effects*; D006801:Humans; D007267:Injections; D009215:Myometrium / Q000187:drug effects*; D011654:Pulmonary Edema / Q000139:chemically induced; D014667:Vasopressins / Q000008:administration & dosage / Q000009:adverse effects*
D006490:Hemostatics; D014667:Vasopressins