[A case of HLA-B54 positive silicosis with rheumatoid arthritis and lung cancer].
In the same environment or workplace, some people contract pneumoconiosis, including silicosis, and some do not. This suggests the important role of constitutional predisposition. In Japanese cases with silicosis, the frequency of HLA-B54 was increased and disease susceptibility gene (s) may exist near the HLA-B locus. It is well known that silicosis is frequently accompanied with rheumatoid arthritis, probably due to the effects of silica on the immunological system. We encountered a case of silicosis with rheumatoid arthritis and lung cancer, who was found to have HLA-B54.
Ishii
Yoshikazu
Y
Division of Pulmonary Medicine, Department of Medicine, Jichi Medical University.
Sugiyama
Yukihiko
Y
Bando
Masashi
M
Ohno
Shoji
S
D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000150:complications*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000209:etiology*; D004334:Drug Administration Schedule; D015235:HLA-B Antigens / Q000032:analysis*; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy / Q000209:etiology*; D008297:Male; D012829:Silicosis / Q000150:complications* / Q000276:immunology
D015235:HLA-B Antigens; C113783:HLA-B54 antigen