The Driselase-treated fraction of rice bran is a more effective dietary factor to improve hypertension, glucose and lipid metabolism in stroke-prone spontaneously hypertensive rats compared to ferulic acid.
The aim of this study is to investigate the effects of dietary supplementation with the Driselase-treated fraction (DF) of rice bran and ferulic acid (FA) on hypertension and glucose and lipid metabolism in stroke-prone spontaneously hypertensive rats (SHRSP). Male SHRSP at 4 weeks of age were divided into three groups, and for 8 weeks were fed (1) a control diet based on AIN-93M, (2) a DF of rice bran-supplemented diet at 60 g/kg and (3) an FA-supplemented diet at 0.01 g/kg. Means and standard errors were calculated and the data were tested by one-way ANOVA followed by a least significance difference test. The results showed that both the DF and FA diets significantly improved hypertension as well as glucose tolerance, plasma nitric oxide (NOx), urinary 8-hydroxy-2'-deoxyguanosine and other parameters. In particular, compared to the FA diet, the DF diet produced a significant improvement in urinary NOx, hepatic triacylglycerol and several mRNA expressions of metabolic parameters involved in glucose and lipid metabolisms. The results of the metabolic syndrome-related parameters obtained from this study suggest that the DF diet is more effective than the FA diet.
Ardiansyah
Department of Science of Food Function and Health, Tohoku University, Japan. ardy@biochem.tohoku.ac.jp
Shirakawa
Hitoshi
H
Koseki
Takuya
T
Hashizume
Katsumi
K
Komai
Michio
M
D000080242:8-Hydroxy-2'-Deoxyguanosine; D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology; D015415:Biomarkers / Q000097:blood / Q000652:urine; D001786:Blood Glucose / Q000378:metabolism; D003373:Coumaric Acids / Q000494:pharmacology; D003849:Deoxyguanosine / Q000031:analogs & derivatives / Q000652:urine; D004043:Dietary Fiber / Q000008:administration & dosage*; D005656:Fungal Proteins / Q000494:pharmacology*; D005951:Glucose Tolerance Test; D006026:Glycoside Hydrolases / Q000494:pharmacology*; D006973:Hypertension / Q000178:diet therapy* / Q000378:metabolism; D007668:Kidney / Q000378:metabolism; D050356:Lipid Metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D009569:Nitric Oxide / Q000378:metabolism; D012275:Oryza / Q000187:drug effects*; D007703:Peptidyl-Dipeptidase A / Q000097:blood; D012333:RNA, Messenger / Q000032:analysis; D051381:Rats; D011918:Rats, Inbred SHR; D020133:Reverse Transcriptase Polymerase Chain Reaction; D020521:Stroke / Q000378:metabolism / Q000517:prevention & control
D000959:Antihypertensive Agents; D015415:Biomarkers; D001786:Blood Glucose; D003373:Coumaric Acids; D004043:Dietary Fiber; D005656:Fungal Proteins; D012333:RNA, Messenger; D009569:Nitric Oxide; D000080242:8-Hydroxy-2'-Deoxyguanosine; C004999:ferulic acid; D006026:Glycoside Hydrolases; C035212:driselase; D007703:Peptidyl-Dipeptidase A; D003849:Deoxyguanosine