Quantitative aspects of brain perfusion dynamic induced by BOLD fMRI.
The increase of relative cerebral blood flow (rCBF) may contribute for a change in blood oxygenation level dependent signal (BOLD). The main purpose of this study is to investigate some aspects of perfusional alterations in the human brain in response to a uniform stimulation: hypercapnia induced by breath holding. It was observed that the BOLD signal increased globally during hypercapnia and that it is correlated with the time of breath holding. This signal increase shows a clear distinction between gray and white matter, being greater in the grey matter.
Andrade
Katia C
KC
Dept. of Physics and Math, FFCLRP, USP, Ribeirão Preto, SP, Brazil.
Pontes-Neto
Octavio M
OM
Leite
Joao P
JP
Santos
Antonio Carlos
AC
Baffa
Oswaldo
O
de Araujo
Draulio B
DB
D001783:Blood Flow Velocity / Q000502:physiology; D001921:Brain / Q000098:blood supply* / Q000503:physiopathology; D001931:Brain Mapping; D005260:Female; D006801:Humans; D006935:Hypercapnia / Q000503:physiopathology*; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D010100:Oxygen / Q000097:blood*; D012039:Regional Blood Flow / Q000502:physiology; D012119:Respiration
D010100:Oxygen