title: Effects of glutathione and ascorbic acid on streptomycin sensitivity of Escherichia coli.
abstract: We examined the effects of antioxidants and the role of reactive oxygen species (ROS) on the antibacterial action of aminoglycosides in Escherichia coli. We concluded that reduced streptomycin sensitivity in the presence of glutathione and ascorbic acid is not due to the antioxidant-mediated scavenging of ROS.
authors.affiliation: Molecular Biology Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400085, India.
authors.forename: Manish
authors.initials: M
authors.lastname: Goswami
authors.forename: Suhas H
authors.initials: SH
authors.lastname: Mangoli
authors.forename: Narendra
authors.initials: N
authors.lastname: Jawali
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000494:pharmacology*; D002374:Catalase / Q000235:genetics; D004926:Escherichia coli / Q000187:drug effects*; D005978:Glutathione / Q000494:pharmacology*; D007202:Indicators and Reagents; D009580:Nitroblue Tetrazolium; D010544:Peroxidases / Q000235:genetics; D054464:Peroxiredoxins; D017382:Reactive Oxygen Species / Q000378:metabolism; D013307:Streptomycin / Q000494:pharmacology*; D013482:Superoxide Dismutase / Q000235:genetics
chemical_list: D000900:Anti-Bacterial Agents; D000975:Antioxidants; D007202:Indicators and Reagents; D017382:Reactive Oxygen Species; D009580:Nitroblue Tetrazolium; D010544:Peroxidases; D054464:Peroxiredoxins; D002374:Catalase; D013482:Superoxide Dismutase; D005978:Glutathione; D001205:Ascorbic Acid; D013307:Streptomycin