title: Histocompatibility class I and II antigens in extensive kindred with Sneddon's syndrome and related hypercoagulation disorders.
abstract: We have studied the relationship between the histocompatibility class I and II antigens and Sneddon's syndrome (SS) in a Spanish patient with SS and her relatives (13 available members of an extensive 3-generation pedigree with diverse autoimmune hypercoagulation abnormalities). The patient and her father were diagnosed with a primary antiphospholipid antibody syndrome and were HLA-A30-B13-Bw6. In addition, a HLA-Bw6-DQ1 association was present in all the members of this kindred. These data suggest that the combination of the histocompatibility class I and II antigens in this family may be a marker for predisposition to SS.
authors.affiliation: S. de Neurología, Hospital Insular, Las Palmas, Spain.
authors.forename: Manuel
authors.initials: M
authors.lastname: Lousa
authors.forename: Ana
authors.initials: A
authors.lastname: Pardo
authors.forename: Antonio
authors.initials: A
authors.lastname: Arnaiz-Villena
authors.forename: Adriano
authors.initials: A
authors.lastname: Jimenez-Escrig
authors.forename: Jose
authors.initials: J
authors.lastname: Gobernado
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001778:Blood Coagulation Disorders / Q000175:diagnosis / Q000235:genetics / Q000276:immunology*; D002648:Child; D003937:Diagnosis, Differential; D005260:Female; D020022:Genetic Predisposition to Disease; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D000949:Histocompatibility Antigens Class II / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D018860:Sneddon Syndrome / Q000175:diagnosis / Q000235:genetics / Q000276:immunology*; D019851:Thrombophilia / Q000175:diagnosis / Q000235:genetics / Q000276:immunology
chemical_list: D015395:Histocompatibility Antigens Class I; D000949:Histocompatibility Antigens Class II