title: Autopsy findings in patients on postcardiotomy extracorporeal membrane oxygenation (ECMO).
abstract: OBJECTIVE
  To assess the clinical sensitivity of causes of death, concomitant diseases and postoperative complications including thromboembolic events in ECMO patients.
  
  
  METHODS
  Between January 2000 and December 2004 154/202 patients (76.2%) died after postcardiotomy ECMO circulatory support. Autopsy was performed in 78 (50.6%) consecutive patients. Clinical and post-mortem data were prospectively recorded and compared concerning causes of death and postoperative complications including venous and arterial thromboembolisms and significant comorbidities.
  
  
  RESULTS
  Mean age was 62.1+/-11.3 years, ejection fraction was 43.4+/-17.3%. 39.7% were emergency operations including acute coronary syndrome in 25.6% and preoperative cardiogenic shock in 28.2%. Successful ECMO weaning rate was 43.6%. Mean postoperative survival was 11.3 days. Premortem unknown concomitant diseases were found in 63 patients (80.8%) with clinical relevance in 9 patients (11.5%). Clinically unrecognized postoperative complications were found in 59 patients (75.6%) including acute cerebral infarction (n=7), acute bowel ischemia (1), intestinal perforation (3), pneumonia (4), venous thrombus formation (25) and systemic thromboembolic events (24). Clinically based causes of death were cardiac in 62.8%, multi-organ failure in 10.3%, cerebral in 5.1%, respiratory in 10.3%, fatal pulmonary embolism in 2.6%, technical in 5.1%, and others in 3.8%. Unexpected causes of death were found by autopsy in 22 patients (28.2%) including myocardial infarction (n=5), acute heart failure (4), fatal pulmonary embolism (2), pneumonia (2), ARDS (1), lung bleeding (1), fatal cerebrovascular event (4) and multiorgan failure (3).
  
  
  CONCLUSIONS
  In ECMO patients major discrepancies between clinical and post-mortem examination were found. The true incidence of thromboembolic events is highly underestimated by clinical evaluation.
authors.affiliation: University of Leipzig, Cardiac Surgery, Heart Center Leipzig, Leipzig, Germany. rastan@rz.uni-leipzig.de
authors.forename: A J
authors.initials: AJ
authors.lastname: Rastan
authors.forename: N
authors.initials: N
authors.lastname: Lachmann
authors.forename: T
authors.initials: T
authors.lastname: Walther
authors.forename: N
authors.initials: N
authors.lastname: Doll
authors.forename: T
authors.initials: T
authors.lastname: Gradistanac
authors.forename: J F
authors.initials: JF
authors.lastname: Gommert
authors.forename: S
authors.initials: S
authors.lastname: Lehmann
authors.forename: C
authors.initials: C
authors.lastname: Wittekind
authors.forename: F W
authors.initials: FW
authors.lastname: Mohr
mesh_terms: D000368:Aged; D001344:Autopsy; D002303:Cardiac Output, Low / Q000209:etiology / Q000473:pathology* / Q000628:therapy; D006348:Cardiac Surgical Procedures / Q000009:adverse effects*; D002423:Cause of Death; D015199:Extracorporeal Membrane Oxygenation / Q000009:adverse effects* / Q000401:mortality*; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D013923:Thromboembolism / Q000209:etiology / Q000401:mortality / Q000473:pathology