In vitro activity of aurein 1.2 alone and in combination with antibiotics against gram-positive nosocomial cocci.
This study was performed to evaluate the in vitro activity of the amphibian peptide aurein 1.2 and to investigate its interaction with six antibiotics against nosocomial gram-positive cocci. All isolates were inhibited at concentrations of 1 to 16 mg/liter. Synergy was demonstrated when aurein 1.2 was combined with clarithromycin and minocycline.
Giacometti
Andrea
A
Institute of Infectious Diseases and Public Health, Università Politecnica delle Marche, c/o Ospedale Regionale, via Conca, 71, Ancona, I-60020, Italy. anconacmi@interfree.it
Cirioni
Oscar
O
Riva
Alessandra
A
Kamysz
Wojciech
W
Silvestri
Carmela
C
Nadolski
Piotr
P
Della Vittoria
Agnese
A
Łukasiak
Jerzy
J
Scalise
Giorgio
G
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D023181:Antimicrobial Cationic Peptides / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use; D003428:Cross Infection / Q000188:drug therapy; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D006095:Gram-Positive Cocci / Q000187:drug effects* / Q000378:metabolism; D008826:Microbial Sensitivity Tests
D000900:Anti-Bacterial Agents; D023181:Antimicrobial Cationic Peptides; C506635:aurein 1.2 peptide