High-density lipoprotein cholesterol: a potential therapeutic target for prevention of coronary artery disease.
High-density lipoprotein cholesterol has an important role in the pathophysiology of coronary artery disease. High-density lipoprotein cholesterol is becoming an increasingly important prognostic and therapeutic target. The purpose of this paper is to review the biochemical pathways involved in reverse cholesterol transport and to discuss potential, clinically based high-density lipoprotein therapies that may contribute to reduction in risk of atherosclerosis.
Chernobelsky
Alexander
A
Division of Cardiovascular Medicine, Department of Medicine, Lenox Hill Hospital, New York, NY 10021, USA.
Ashen
M Dominique
MD
Blumenthal
Roger S
RS
Coplan
Neil L
NL
D018528:ATP-Binding Cassette Transporters / Q000378:metabolism; D000924:Anticholesteremic Agents / Q000494:pharmacology; D001692:Biological Transport; D053480:Cholesterol Ester Transfer Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism; D008076:Cholesterol, HDL / Q000097:blood / Q000378:metabolism*; D003324:Coronary Artery Disease / Q000097:blood / Q000517:prevention & control*; D006801:Humans
D018528:ATP-Binding Cassette Transporters; D000924:Anticholesteremic Agents; C506642:CETP protein, human; D053480:Cholesterol Ester Transfer Proteins; D008076:Cholesterol, HDL