title: Extensive local and systemic therapy in extraneural metastasized glioblastoma multiforme.
abstract: Cases of extracranial metastases of glioblastoma multiforme to sites such as bones, spleen, lung, liver and kidneys have been reported but available information about treatment of organ and bone metastases is extremely scarce. In this report a case of glioblastoma multiforme (GBM) of the temporal lobe with subsequent liver and bone metastases is described and the success of different chemotherapy regimens is discussed. Liver and bone metastases were effectively treated with temozolomide and later with carboplatin and docetaxel. Two years after first diagnosis symptomatic local recurrence occurred. Therefore a stereotactic fractionated radiotherapy was performed. As a result of relapse of liver metastases the patient received chemotherapy with adriamycin, cyclophosphamide and etoposide. Visceral metastases were stable, but nevertheless the patient died from local progression 3 years after first diagnosis. In conclusion, liver metastases of GBM can be effectively treated by chemotherapy. This case report suggests suitable substances which can be chosen according to clinical circumstances.
authors.affiliation: Department of Radiation Oncology, Technical University of Munich, Germany. sabrina.astner@gmx.de
authors.forename: Sabrina T
authors.initials: ST
authors.lastname: Astner
authors.forename: Rudolf
authors.initials: R
authors.lastname: Pihusch
authors.forename: Carsten
authors.initials: C
authors.lastname: Nieder
authors.forename: Walter
authors.initials: W
authors.lastname: Rachinger
authors.forename: Hanns
authors.initials: H
authors.lastname: Lohner
authors.forename: Joerg Christian
authors.initials: JC
authors.lastname: Tonn
authors.forename: Michael
authors.initials: M
authors.lastname: Molls
authors.forename: Anca-Ligia
authors.initials: AL
authors.lastname: Grosu
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001859:Bone Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy / Q000556:secondary*; D005909:Glioblastoma / Q000188:drug therapy* / Q000532:radiotherapy / Q000556:secondary; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy / Q000556:secondary*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy / Q000532:radiotherapy