title: Caries-related saliva properties in individuals with 22q11 deletion syndrome.
abstract: OBJECTIVE
  The aims were to compare saliva secretion rate, buffer capacity, cariogenic bacteria, total protein, IgA, and electrolytes between patients with 22q11 deletion syndrome (22q11DS) and control subjects and to study correlations between saliva and serum levels of IgA and electrolytes in 22q11DS patients.
  
  
  METHODS
  Twenty-nine consecutive 22q11DS patients (mean age 12.6 years) and matched healthy control subjects were clinically examined, and stimulated saliva samples were collected.
  
  
  RESULTS
  Patients with 22q11DS had impaired salivary secretion rate (P < .01) and buffer capacity (P < .05), higher numbers of cariogenic bacteria (P < .01), increased saliva protein concentrations (P < .001), and reduced output of electrolytes (P < .001-.05) compared with control subjects. A correlation between concentration in serum and saliva was found only for IgA (r = .622; P < .01).
  
  
  CONCLUSIONS
  Different salivary components were affected in patients with 22q11DS, which may explain the increased caries risk seen in these patients.
authors.affiliation: Mun-H-Center, National Orofacial Resource Center, Göteborg, Sweden. gunilla.klingberg@vgregion.se
authors.forename: Gunilla
authors.initials: G
authors.lastname: Klingberg
authors.forename: Peter
authors.initials: P
authors.lastname: Lingström
authors.forename: Sólveig
authors.initials: S
authors.lastname: Oskarsdóttir
authors.forename: Vanda
authors.initials: V
authors.lastname: Friman
authors.forename: Eva
authors.initials: E
authors.lastname: Bohman
authors.forename: Anette
authors.initials: A
authors.lastname: Carlén
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D002872:Chromosome Deletion; D002892:Chromosomes, Human, Pair 22 / Q000235:genetics*; D003731:Dental Caries / Q000097:blood / Q000382:microbiology*; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D008297:Male; D012463:Saliva / Q000737:chemistry* / Q000378:metabolism; D012471:Salivary Proteins and Peptides / Q000032:analysis; D012472:Salivation; D018709:Statistics, Nonparametric; D013577:Syndrome
chemical_list: D007070:Immunoglobulin A; D012471:Salivary Proteins and Peptides