title: Exploring efferent-mediated DPOAE adaptation in three different guinea pig strains.
abstract: The aims of this study were to explore the correlation between DPOAE adaptation magnitude in three different guinea pig strains to examine if the genetic component affects the DPOAE adaptation magnitude. It was also to investigate the correlation between strains with certain characteristics i.e. reduced susceptibility to noise, and early onset of age-dependent hearing loss and the DPOAE adaptation magnitude. The animals were anaesthetized and the 2f1-f2 DPOAE (f1=8k Hz, and f2/f1=1.2) adaptation was established with a minimum of 144 combinations of f1; f2 where f1 was held fixed and f2 was varied in 1 dB or 0.4 dB steps. The DPOAE adaptation magnitude was defined as the difference between maximum positive level and the maximum negative level. ABRs were conducted at different age-groups (at 4, 6.3, and 12.5k Hz) to evaluate the progress of hearing thresholds by age. There was a significant difference between strains regarding the hearing loss at one year of age. There was no significant difference in DPOAE adaptation magnitude between strains included in this study and from this we conclude that the DPOAE adaptation magnitude is not a predictor for the susceptibility to noise trauma, or early onset of age-dependent hearing loss, using the methods described in this paper.
authors.affiliation: Center for Hearing and Communication Research, Department of Clinical Neuroscience, Karolinska Institute, Building M1:00, Karolinska University Hospital, Solna, SE-171 76 Stockholm, Sweden. asa.skjonsberg@ki.se
authors.forename: Asa
authors.initials: A
authors.lastname: Skjönsberg
authors.forename: Kärin
authors.initials: K
authors.lastname: Halsey
authors.forename: Mats
authors.initials: M
authors.lastname: Ulfendahl
authors.forename: David F
authors.initials: DF
authors.lastname: Dolan
mesh_terms: D000222:Adaptation, Physiological; D000375:Aging / Q000502:physiology; D000818:Animals; D001309:Auditory Threshold; D004195:Disease Models, Animal; D004525:Efferent Pathways / Q000502:physiology; D016057:Evoked Potentials, Auditory, Brain Stem; D006168:Guinea Pigs / Q000235:genetics / Q000502:physiology*; D006317:Hearing Loss, Noise-Induced / Q000209:etiology / Q000235:genetics / Q000503:physiopathology; D017084:Otoacoustic Emissions, Spontaneous / Q000235:genetics / Q000502:physiology*; D011304:Presbycusis / Q000209:etiology / Q000235:genetics / Q000503:physiopathology; D012022:Reflex, Acoustic; D013045:Species Specificity