title: Arsenic trioxide and acute promyelocytic leukemia: clinical and biological.
abstract: Arsenic has recently been identified as an effective drug in the treatment of newly diagnosed and relapsed acute promyelocytic leukemia. Indeed, arsenic trioxide combined with all-trans retinoic acid shows a synergistic effect. Mechanistically, arsenic targets the key leukemogenic protein PML-RARalpha, setting up a new example of molecular target-based cancer therapy.
authors.affiliation: Shanghai Institute of Hematology, Rui Jin Hospital, School of Medicine, Shanghai Jiao Tong University, 197 Rui Jin Road II, 200025 Shanghai, People's Republic of China. zchen@stn.sh.cn
authors.forename: Z
authors.initials: Z
authors.lastname: Chen
authors.forename: W L
authors.initials: WL
authors.lastname: Zhao
authors.forename: Z X
authors.initials: ZX
authors.lastname: Shen
authors.forename: J M
authors.initials: JM
authors.lastname: Li
authors.forename: S J
authors.initials: SJ
authors.lastname: Chen
authors.forename: J
authors.initials: J
authors.lastname: Zhu
authors.forename: V
authors.initials: V
authors.lastname: Lallemand-Breittenbach
authors.forename: J
authors.initials: J
authors.lastname: Zhou
authors.forename: M C
authors.initials: MC
authors.lastname: Guillemin
authors.forename: D
authors.initials: D
authors.lastname: Vitoux
authors.forename: H
authors.initials: H
authors.lastname: de Thé
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D000077237:Arsenic Trioxide; D001152:Arsenicals / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000188:drug therapy*; D010087:Oxides / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D001152:Arsenicals; D010087:Oxides; D000077237:Arsenic Trioxide