Serum mesothelin in epithelial ovarian carcinoma: a new screening marker and prognostic factor.
The aim of this study was to determine the relationship between mesothelin and clinical pathological characteristics and whether mesothelin can be used as a biomarker for the detection and prognosis of epithelial ovarian carcinoma, or not.


METHODS
Pre-operative mesothelin and CA125 levels from normal populations, patients with benign ovarian tumors and patients with ovarian carcinomas were measured. The histopathological characteristics and serum meosthelin, and CA125 levels influencing clinical outcome were evaluated comparatively.


RESULTS
Mesothelin levels were higher in cancer patients than in those with benign ovarian tumors or in normal populations. Mesothelin, also significantly increased from early to advanced stages. Elevated mesothelin before therapy and advanced stage, revealed poorer overall survival (OS) for cancer patients. Elevated mesothelin before therapy also revealed poorer OS in cancer patients with optimal debulking surgery and in advanced-stage cancer patients.


CONCLUSIONS
Mesothelin might be a new tumor marker for the differential diagnosis of epithelial ovarian carcinoma and a prognostic factorfor the outcome of epithelial ovarian carcinoma patients.
Huang
Chia-Yen
CY
Department of Obstetrics and Gynecology, College of Medicine, National Taiwan University, Taipei, Taiwan.
Cheng
Wen-Fang
WF
Lee
Chien-Nan
CN
Su
Yi-Ning
YN
Chien
Shu-Chin
SC
Tzeng
Yu-Lin
YL
Hsieh
Chang-Yao
CY
Chen
Chi-An
CA
D000328:Adult; D018394:CA-125 Antigen / Q000097:blood; D003537:Cystadenoma / Q000097:blood / Q000473:pathology; D004847:Epithelial Cells / Q000473:pathology; D005260:Female; D058851:GPI-Linked Proteins; D006801:Humans; D008562:Membrane Glycoproteins / Q000097:blood*; D000090204:Mesothelin; D008875:Middle Aged; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000097:blood* / Q000473:pathology / Q000601:surgery; D011300:Preoperative Care; D011379:Prognosis
D018394:CA-125 Antigen; D058851:GPI-Linked Proteins; D008562:Membrane Glycoproteins; D000090204:Mesothelin