Skin barrier function in atopic dermatitis.
OBJECTIVE
Whereas much investigation in atopic dermatitis has focused upon the adaptive immune response, new data suggest that allergic sensitization may occur secondary to impairment of skin barrier function.


RESULTS
Two common loss-of-function mutations in the FLG gene encoding filaggrin (an important component of terminal keratinocyte differentiation) are strongly associated with the development of atopic dermatitis and asthma associated with atopic dermatitis.


CONCLUSIONS
Genetic defects in skin barrier function should be recognized as major risk factors for the development of atopic dermatitis and asthma.
Vickery
Brian P
BP
Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA. brain.vickery@yale.edu
D002648:Child; D003876:Dermatitis, Atopic / Q000235:genetics* / Q000276:immunology; D000091344:Filaggrin Proteins; D006801:Humans; D007381:Intermediate Filament Proteins / Q000172:deficiency / Q000235:genetics* / Q000276:immunology; D012307:Risk Factors; D012879:Skin Physiological Phenomena / Q000235:genetics* / Q000276:immunology
C000717249:FLG protein, human; D000091344:Filaggrin Proteins; D007381:Intermediate Filament Proteins