'Prope' tolerance in a noncompliant living related small bowel transplant recipient after severe rejection.
Advances in immunosuppression and surgical technique have greatly improved patient outcomes after intestinal transplantation. However, the procedure remains one of the most challenging among solid organ transplantation as a result of the high rate of acute rejection, sepsis, and posttransplantation lymphoproliferative disorder. Recently, clinical trials to explore tolerance protocols in humans have been initiated, including small bowel transplant recipients, with results not always reproducible. The concept of operational tolerance is more meaningful in the clinical setting when physiological stability of graft function is achieved in the absence of maintenance immunosuppression. We report the intriguing case of a living related small bowel transplant recipient who developed clinical "prope" tolerance to the graft after treatment of severe acute rejection despite continuous noncompliance with immunosuppressive therapy.
Asolati
Massimo
M
Division of Transplantation, Department of Surgery, University of Illinois at Chicago, Chicago, IL, USA.
Testa
Giuliano
G
Gangemi
Antonio
A
Sankary
Howard
H
Oberholzer
José
J
Benedetti
Enrico
E
D000328:Adult; D001706:Biopsy; D006084:Graft Rejection / Q000276:immunology*; D006801:Humans; D007082:Ileum / Q000637:transplantation*; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D019520:Living Donors; D008297:Male; D023001:Transplantation Tolerance / Q000276:immunology*; D014184:Transplantation, Homologous / Q000276:immunology* / Q000473:pathology; D016312:Treatment Refusal
D007166:Immunosuppressive Agents