title: Early cleavage: an additional predictor of high implantation rate following elective single embryo transfer.
abstract: The value of early cleavage (EC) assessment is still being debated. The aim of this prospective study was to examine the predictive value of EC assessment performed exactly 26 h after insemination by IVF or intracytoplasmic sperm injection (ICSI) in a programme of elective single embryo transfer (SET) performed at day 2. If day 2 scoring demonstrated several embryos with high implantation potential, an EC embryo was transferred preferentially. EC was assessed only during normal laboratory hours so that there were two groups: EC assessed, and EC not assessed, the latter being the control. A total of 277 elective SET were performed in women under 37 years undergoing their first IVF or ICSI cycle (mean age 30.5 years, range 21-37). The overall clinical and ongoing pregnancy rates were 40.1% (111/277) and 32.9% (91/277) respectively. Significantly higher overall clinical and ongoing pregnancy rates were obtained after transfer of an EC embryo than a non-EC embryo: 49.4 versus 33.3% (P < 0.05) and 42.4 versus 25.9% (P < 0.02) respectively. However there was no significant difference between the EC assessed and control groups: 40.4 versus 39.3% and 33.2 versus 32.1 respectively. These findings confirm the value of EC assessment for selection of embryos with high implantation potential.
authors.affiliation: Institut de Médecine de la Reproduction, 6 rue Rocca, 13008 Marseille, France. giorgetti.claude@wanadoo.fr
authors.forename: C
authors.initials: C
authors.lastname: Giorgetti
authors.forename: E
authors.initials: E
authors.lastname: Hans
authors.forename: P
authors.initials: P
authors.lastname: Terriou
authors.forename: J
authors.initials: J
authors.lastname: Salzmann
authors.forename: B
authors.initials: B
authors.lastname: Barry
authors.forename: V
authors.initials: V
authors.lastname: Chabert-Orsini
authors.forename: J M
authors.initials: JM
authors.lastname: Chinchole
authors.forename: J P
authors.initials: JP
authors.lastname: Franquebalme
authors.forename: E
authors.initials: E
authors.lastname: Glowaczower
authors.forename: M-C
authors.initials: MC
authors.lastname: Sitri
authors.forename: M-C
authors.initials: MC
authors.lastname: Thibault
authors.forename: R
authors.initials: R
authors.lastname: Roulier
mesh_terms: D000328:Adult; D010064:Embryo Implantation; D004624:Embryo Transfer / Q000592:standards; D004622:Embryo, Mammalian / Q000166:cytology*; D047108:Embryonic Development; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D011247:Pregnancy; D018873:Pregnancy Rate; D011446:Prospective Studies