An introduction to genetics and application to Crohn's disease.
Gene-based diagnostics and therapeutics are being explored for application in many areas of healthcare. An understanding of the principles of genomics has become fundamental to patient care within all specialties of nursing and is expected to be included in certification exams in the near future. This introductory article is designed to provide practicing Wound, Ostomy, and Continence nurses with basic information to enhance their abilities to comprehend genetics information, apply it to practice, and translate it to colleagues and patients. Specifics about the genetic basis of Crohn's disease are used to illustrate the application of the concepts described in the article.
Briones
Tess
T
Department of Medical-Surgical Nursing, College of Nursing, University of Illinois at Chicago, IL, USA.
Salvadalena
Ginger
G
D017398:Alternative Splicing / Q000235:genetics; D002983:Clinical Competence; D003424:Crohn Disease / Q000175:diagnosis / Q000235:genetics* / Q000451:nursing*; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005821:Genetic Techniques; D005820:Genetic Testing; D005826:Genetics, Medical / Q000193:education*; D005828:Genetics, Population; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics; D009154:Mutation / Q000235:genetics; D053473:Nod2 Signaling Adaptor Protein / Q000235:genetics; D009720:Nurse Clinicians / Q000193:education*; D024802:Nurse's Role; D027701:Organic Cation Transport Proteins / Q000235:genetics; D010597:Pharmacogenetics; D014176:Protein Biosynthesis / Q000235:genetics; D017592:Skin Care / Q000451:nursing*; D000074058:Solute Carrier Family 22 Member 5; D027981:Symporters; D014158:Transcription, Genetic / Q000235:genetics; D025521:Tumor Suppressor Proteins / Q000235:genetics
C114461:DLG5 protein, human; D008565:Membrane Proteins; D053473:Nod2 Signaling Adaptor Protein; D027701:Organic Cation Transport Proteins; C109807:SLC22A4 protein, human; C492020:SLC22A5 protein, human; D000074058:Solute Carrier Family 22 Member 5; D027981:Symporters; D025521:Tumor Suppressor Proteins