title: Meta-analysis: the efficacy of over-the-counter gastro-oesophageal reflux disease therapies.
abstract: BACKGROUND
  Over-the-counter histamine-2 receptor antagonists, antacids and alginate/antacids are commonly used for gastro-oesophageal reflux disease.
  
  
  OBJECTIVE
  To conduct a systematic review and meta-analysis of related treatment trials.
  
  
  METHODS
  We performed a systematic search and abstraction of randomized, placebo-controlled trials conducted during 1972-2005. Study quality was measured by the Jadad score (0-5). Results were pooled using random effects model.
  
  
  RESULTS
  Ten trials (n = 3442, placebo = 2940; Jadad score 3.5) showed a higher response with histamine-2 receptor antagonists in regard to complete relief of heartburn, symptomatic improvement, and episodes requiring rescue antacids. The absolute benefit increase was 10-12% and relative benefit increase was 19-41%. Four trials (n = 578, placebo = 577; Jadad score 3.5) showed a trend in favour of antacids in symptomatic improvement (absolute benefit increase 8%, 95% CI: 0-16%; relative benefit increase 0.11) and requirement of rescue antacids (OR 0.70, 95% CI: 0.59-0.84). Four trials (n = 146, placebo = 138; Jadad score 3.8) found alginate/antacid combination superior to placebo in symptomatic improvement (absolute benefit increase 26%, 95% CI: 12%-41%, relative benefit increase 0.60).
  
  
  CONCLUSIONS
  Over-the-counter medications are effective in treating symptomatic gastro-oesophageal reflux disease. Compared with the placebo response, which ranged between 37% and 64%, the relative benefit increase was up to 41% with histamine-2 receptor antagonists, 60% with alginate/antacid combinations, and 11% with antacids.
authors.affiliation: The Sections of Health Services Research and Gastroenterology at the Houston Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX 77030, USA.
authors.forename: T
authors.initials: T
authors.lastname: Tran
authors.forename: A M
authors.initials: AM
authors.lastname: Lowry
authors.forename: H B
authors.initials: HB
authors.lastname: El-Serag
mesh_terms: D000863:Antacids / Q000627:therapeutic use*; D005764:Gastroesophageal Reflux / Q000188:drug therapy*; D006635:Histamine H2 Antagonists / Q000627:therapeutic use*; D006801:Humans; D004366:Nonprescription Drugs / Q000627:therapeutic use*; D016032:Randomized Controlled Trials as Topic
chemical_list: D000863:Antacids; D006635:Histamine H2 Antagonists; D004366:Nonprescription Drugs