SiiE is secreted by the Salmonella enterica serovar Typhimurium pathogenicity island 4-encoded secretion system and contributes to intestinal colonization in cattle.
Here we report that Salmonella enterica serovar Typhimurium pathogenicity island 4 carries a type I secretion system (siiCDF) which secretes an approximately 600-kDa protein (encoded by siiE). SiiE is surface expressed, and its production is regulated by HilA. SiiE and SiiF influence colonization in cattle and the invasion of bovine enterocytes.
Morgan
Eirwen
E
Division of Microbiology, Institute for Animal Health, Compton, Nr Newbury, Berkshire, RG20 7NN, United Kingdom. eirwen.morgan@bbsrc.ac.uk
Bowen
Alison J
AJ
Carnell
Sonya C
SC
Wallis
Timothy S
TS
Stevens
Mark P
MP
D000818:Animals; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D002417:Cattle; D044404:Genomic Islands / Q000502:physiology*; D007413:Intestinal Mucosa / Q000382:microbiology*; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism; D012486:Salmonella typhimurium / Q000235:genetics / Q000472:pathogenicity*; D037521:Virulence Factors / Q000235:genetics* / Q000502:physiology
D001426:Bacterial Proteins; D008565:Membrane Proteins; D037521:Virulence Factors