Thinking within the D box: initial identification of Cdh1-APC substrates in the nervous system.
The anaphase-promoting complex (APC) has a well-established role in cell cycle control, but recent exciting evidence has uncovered unexpected neurobiological functions for this complex E3 ubiquitin ligase. With its co-activator Cdh1, APC's effects upon the nervous system range from regulation of axon growth and patterning to development of synapses to neuronal survival. The Cdh1-APC substrates that control these biological processes in neurons are just beginning to be identified. These findings may offer a glimpse of the wide spectrum of neural activities that are orchestrated by Cdh1-APC.
Kim
Albert H
AH
Department of Pathology, Harvard Medical School, New Research Building, 77 Ave Louis Pasteur, Room 856, Boston, MA 02115, USA.
Bonni
Azad
A
D064173:Anaphase-Promoting Complex-Cyclosome; D000818:Animals; D001369:Axons / Q000378:metabolism; D015820:Cadherins / Q000378:metabolism*; D002453:Cell Cycle / Q000502:physiology; D016923:Cell Death / Q000502:physiology; D006801:Humans; D009420:Nervous System / Q000166:cytology / Q000378:metabolism*; D013569:Synapses / Q000502:physiology; D043743:Ubiquitin-Protein Ligase Complexes / Q000378:metabolism*
D015820:Cadherins; D043743:Ubiquitin-Protein Ligase Complexes; D064173:Anaphase-Promoting Complex-Cyclosome