Prostate cancer detection in men with an initial diagnosis of atypical small acinar proliferation.
OBJECTIVE
To determine the subsequent prostatic adenocarcinoma detection rate amongst men with an initial diagnosis of atypical small acinar proliferation (ASAP).


METHODS
We reviewed the Illawarra Prostate Pathology Database over a 10-year period (January 1994 to January 2004) for specimens diagnosed as ASAP. These specimens were re-reviewed and clinical data obtained.


RESULTS
Of 61 cases of ASAP, there were complete follow-up data for 31. In this group nine patients had no further biopsies at our institution; the other 22 had at least one repeat biopsy. The incidence of prostatic adenocarcinoma in this group was 17/31 (55%). This included 13 diagnoses on second biopsy, three on third biopsy and one diagnosed at another institution.


CONCLUSIONS
This study showed a detection rate for prostatic adenocarcinoma of 55% after an initial diagnosis of ASAP, which indicates that an initial diagnosis of ASAP mandates re-biopsy.
Mancuso
Pascal A
PA
Department of Urology, The Wollongong Hospital, Sydney, NSW, Australia. pascalmancuso@hotmail.com
Chabert
Charles
C
Chin
Peter
P
Kovac
Paul
P
Skyring
Timothy
T
Watt
William H
WH
Napaki
Sabar
S
D000368:Aged; D001707:Biopsy, Needle; D018267:Carcinoma, Acinar Cell / Q000473:pathology*; D049109:Cell Proliferation; D015331:Cohort Studies; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D017430:Prostate-Specific Antigen / Q000097:blood; D019048:Prostatic Intraepithelial Neoplasia / Q000473:pathology*; D011471:Prostatic Neoplasms / Q000473:pathology*; D012189:Retrospective Studies
D017430:Prostate-Specific Antigen