title: Evidence of positive selection on the Atlantic salmon CD3gammadelta gene.
abstract: Atlantic salmon are typically anadromous, spending the majority of their lifetime in oceans and returning to fresh water to breed. This diversity of environments likely results in strong selective forces shaping their genome. In this paper, we present the first genomics approach to detect positive selection operating on the Salmo salar (salmon) lineage, an important aquaculture species. We identify a panel of candidate genes that may have been subject to adaptive evolution in this species. In particular, we identify a robust signature of positive selection operating on the salmon CD3gammadelta gene, which encodes one of the protein chains essential for formation of the T-cell receptor complex and for T-cell activation. Furthermore, we identified the particular codon sites that have been subject to positive selection in fish and highlight two sites flanking an important N-glycosylation site in this molecule.
authors.affiliation: Smurfit Institute of Genetics, Trinity College Dublin, Dublin 2, Ireland.
authors.forename: Fernando
authors.initials: F
authors.lastname: Cruz
authors.forename: Daniel G
authors.initials: DG
authors.lastname: Bradley
authors.forename: David J
authors.initials: DJ
authors.lastname: Lynn
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D017252:CD3 Complex / Q000235:genetics*; D003062:Codon; D019143:Evolution, Molecular; D008969:Molecular Sequence Data; D017686:Oncorhynchus mykiss; D010802:Phylogeny; D020317:Salmo salar / Q000235:genetics*; D012641:Selection, Genetic; D017386:Sequence Homology, Amino Acid
chemical_list: D017252:CD3 Complex; D003062:Codon