The association between hyperuricemia and the Trp64Arg polymorphism of the beta-3 adrenergic receptor.
The object of this study was to determine the association of Trp64Arg polymorphism with hyperuricemia. This study is an age-matched, case-controlled study of 203 hyperuricemic and 203 normouricemic men. The frequency of genotypes was compared between the two groups. Possible confounding metabolic variables were included in a multiple logistic regression model for multivariate adjustment. The genotype frequencies of Trp64Trp, Trp64Arg, and Arg64Arg in hyperuricemic and normouricemic groups are respectively 130, 69, and 4 (64.0%, 34.0%, 2.0%) and 154, 45, and 4 (75.9%, 22.2%, 2.0%) (P = 0.029, Chi-square test). Simple logistic regression analysis indicated that the Trp64Arg genotype is significantly associated with hyperuricemia (OR = 1.816, 95% CI (1.167-2.827), P = 0.008). Multivariate analysis for controlling metabolic effects also showed a significant association with the occurrence of hyperuricemia (OR = 1.937, 95% CI (1.149-3.266), P = 0.013). Trp64Arg polymorphism of the beta-3 adrenergic receptor may be independently associated with hyperuricemia in males.
Rho
Young Hee
YH
Division of Rheumatology, Department of Internal Medicine, Korea University Guro Hospital, 97, Gurodong-Gil, Guro-Gu, 152-703 Seoul, South Korea.
Choi
Seong Jae
SJ
Lee
Young Ho
YH
Ji
Jong Dae
JD
Song
Gwan Gyu
GG
D000328:Adult; D000595:Amino Acid Sequence / Q000235:genetics; D019943:Amino Acid Substitution / Q000235:genetics; D001120:Arginine / Q000235:genetics; D004252:DNA Mutational Analysis; D005787:Gene Frequency; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005820:Genetic Testing; D005838:Genotype; D006801:Humans; D033461:Hyperuricemia / Q000235:genetics* / Q000378:metabolism* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D017354:Point Mutation / Q000235:genetics; D011110:Polymorphism, Genetic / Q000235:genetics*; D022702:Receptors, Adrenergic, beta-3 / Q000235:genetics*; D012737:Sex Factors; D014364:Tryptophan / Q000235:genetics
D005819:Genetic Markers; D022702:Receptors, Adrenergic, beta-3; D014364:Tryptophan; D001120:Arginine