title: Expression of Syk in invasive breast cancer: correlation to proliferation and invasiveness.
abstract: BACKGROUND
  Spleen tyrosine kinase (Syk) kinase has recently been considered as a tumor suppressor gene in breast cancer.
  
  
  METHODS
  Syk expression in patients with invasive breast cancer was immunohistochemically assessed.
  
  
  RESULTS
  Decreased expression was found in 26% of the specimens examined. In cases with vascular invasion, expression of Syk was lost in the intravascular emboli. A significant relationship between increased proliferation levels (as estimated by the proliferative index, Ki67) and decreased Syk expression (p <0.05) was found.
  
  
  CONCLUSIONS
  Our data suggest that Syk protein expression inversely correlates with the proliferation and invasive capacity of breast cancer.
authors.affiliation: Laboratory of Biochemistry, Department of Chemistry, Aristotle University of Thessaloniki, 54124, Thessaloniki, Greece.
authors.forename: Katerina
authors.initials: K
authors.lastname: Repana
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Papazisis
authors.forename: Periklis
authors.initials: P
authors.lastname: Foukas
authors.forename: Rozalia
authors.initials: R
authors.lastname: Valeri
authors.forename: Alexandros
authors.initials: A
authors.lastname: Kortsaris
authors.forename: Eleni
authors.initials: E
authors.lastname: Deligiorgi
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Kyriakidis
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000201:enzymology* / Q000473:pathology; D018567:Breast Neoplasms, Male / Q000201:enzymology* / Q000473:pathology; D048708:Cell Growth Processes / Q000502:physiology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D047908:Intracellular Signaling Peptides and Proteins; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D011505:Protein-Tyrosine Kinases / Q000096:biosynthesis*; D023062:Receptors, Interleukin-8A / Q000096:biosynthesis; D023063:Receptors, Interleukin-8B / Q000096:biosynthesis; D000072377:Syk Kinase
chemical_list: D047908:Intracellular Signaling Peptides and Proteins; D023062:Receptors, Interleukin-8A; D023063:Receptors, Interleukin-8B; D011505:Protein-Tyrosine Kinases; C000606896:SYK protein, human; D000072377:Syk Kinase