[Fundamental research on effect of Ginseng and its components on hematopoiesis and their clinical application].
Ginseng contains multiple components, such as saponins and saccharide, etc. The major is ginsenoside, which includes more than 40 kinds of monomers. It has been applied to treat blood-deficiency syndrome, but the action mechanism is still unclear. The fundamental researches on the effect of ginseng and its components on hematopoiesis and their clinical application were reviewed in this article. They were found to have effects on hematopoietic cells, microenvironment and regulatory factors, indicating they are potential for prevention of hemocytopenia, protection from injury of radiotherapy/chemotherapy and even for transplantation of hematopoietic stem cell.
Wang
Xin
X
Department of Hemopathy, Xiyuan Hospital, China Academy of Chinese Medicial Sciences, Beijing. wangbuliuxing06@yahoo.com.cn
Ma
Rou
R
D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects; D036145:Ginsenosides / Q000302:isolation & purification / Q000494:pharmacology*; D006410:Hematopoiesis / Q000187:drug effects*; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000187:drug effects*; D006801:Humans; D005894:Panax / Q000737:chemistry*
D036145:Ginsenosides