title: [Study on bile excretion of scutellarein].
abstract: OBJECTIVE
  A HPLC-ECD method was established to determine scutellarin in rat bile.
  
  
  METHODS
  The analytical column was Prontosil C18 (4.6 mm x 250 mm, 5 microm), and the mobile phase was consisted of methanol, 50 mmol x L(-1) phosphate buffer (adjusted by phosphoric acid to pH 2. 6), and tetrahydrofuran (40: 60: 10) , the flow rate was 1.0 mL x min(-1); the potential electrode voltage was 100 mv.
  
  
  RESULTS
  Concentration profile of scutellarin in rat bile was shown in this paper after oral administration of scutellarein.
  
  
  CONCLUSIONS
  Only scutellarin was detected in rat bile, while both of scutellarin and scutellarein were detected in rat plasma.
authors.affiliation: School of Pharmaceutical Sciences, Beijing University, Beijing 100083, China. cheqing-ming2003@sina.com
authors.forename: Qing-Ming
authors.initials: QM
authors.lastname: Che
authors.forename: Ying
authors.initials: Y
authors.lastname: Chen
authors.forename: Li-Yi
authors.initials: LY
authors.lastname: Pan
authors.forename: Hong
authors.initials: H
authors.lastname: He
mesh_terms: D000818:Animals; D047310:Apigenin / Q000032:analysis* / Q000097:blood / Q000302:isolation & purification*; D001646:Bile / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D049919:Erigeron / Q000737:chemistry; D005965:Glucuronates / Q000032:analysis*; D008297:Male; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D005965:Glucuronates; C484876:scutellarin; D047310:Apigenin; C458179:scutellarein