[Transcription TIMP3, DAPk1 and AKR1B10 genes in squamous cell lung cancer].
Lung cancer is one of the most frequent neoplasia in the Russia, the United States and Europe. This cancer is associated with functional activity changes of many genes. In the present study TIMP3, DAPK1 and AKR1B10 genes transcription analysis of squamous cell lung cancer specimens was carried out using reverse transcription-PCR. Substantial increasing of AKR1B10 transcription level is revealed in 80% tumor samples. TIMP3 and DAPK1 transcription level is considerably decreased in 76 and 72% tumor specimens, accordingly. These results may point out that all three genes are important for squamous cell lung cancer tumorogenesis while AKR1B10 is potential oncogene whereas TIMP3 and DAPK1 are potential tumor suppressor genes. We suggest that revealed substantial transcription level-changes of investigated genes may be used for oncodiagnostics.
Mashkova
T D
TD
Oparina
N Iu
NIu
Zinov'eva
O L
OL
Kropotova
E S
ES
Dubovaia
V I
VI
Poltaraus
A B
AB
Fridman
M V
MV
Kopantsev
E P
EP
Vinogradova
T V
TV
Zinov'eva
M V
MV
Laktionov
K K
KK
Kasymova
O T
OT
Zborovskaia
I B
IB
Sverdlov
E D
ED
Kiselev
L L
LL
D000328:Adult; D000368:Aged; D000449:Aldehyde Reductase / Q000096:biosynthesis / Q000235:genetics*; D000074408:Aldo-Keto Reductases; D051017:Apoptosis Regulatory Proteins / Q000096:biosynthesis / Q000235:genetics*; D017871:Calcium-Calmodulin-Dependent Protein Kinases / Q000096:biosynthesis / Q000235:genetics*; D002289:Carcinoma, Non-Small-Cell Lung / Q000201:enzymology / Q000235:genetics*; D064550:Death-Associated Protein Kinases; D004790:Enzyme Induction / Q000235:genetics; D004794:Enzyme Repression / Q000235:genetics; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008175:Lung Neoplasms / Q000201:enzymology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D019717:Tissue Inhibitor of Metalloproteinase-3 / Q000096:biosynthesis / Q000235:genetics*; D014158:Transcription, Genetic
D051017:Apoptosis Regulatory Proteins; C088390:TIMP3 protein, human; D019717:Tissue Inhibitor of Metalloproteinase-3; C120471:AKR1B10 protein, human; D000074408:Aldo-Keto Reductases; D000449:Aldehyde Reductase; C579096:DAPK1 protein, human; D064550:Death-Associated Protein Kinases; D017871:Calcium-Calmodulin-Dependent Protein Kinases