title: Probing glycomics.
abstract: The study of protein-carbohydrate interactions is one central theme of glycomics research. The challenges encountered when investigating these interactions have resulted in an approach that studies saccharides through the enzymes that process them. Proteins and their function are often probed by manipulating the genes that encode them. Efforts in proteoglycomics exploring protein-binding properties and the enzymatic modification of carbohydrates have intensified, and synthetic tools, including activity- and affinity-based probes, have enhanced our understanding of the roles of carbohydrates in biology.
authors.affiliation: Laboratory for Organic Chemistry, Swiss Federal Institute of Technology (ETH) Zürich, Wolfgang-Pauli Strasse 10, 8093 Zurich, Switzerland.
authors.forename: Mattie S M
authors.initials: MS
authors.lastname: Timmer
authors.forename: Bridget L
authors.initials: BL
authors.lastname: Stocker
authors.forename: Peter H
authors.initials: PH
authors.lastname: Seeberger
mesh_terms: D002236:Carbohydrate Conformation; D002240:Carbohydrate Sequence; D006031:Glycosylation; D006493:Heparin / Q000032:analysis / Q000737:chemistry / Q000378:metabolism; D007785:Lactose / Q000032:analysis / Q000737:chemistry / Q000378:metabolism; D046228:Microarray Analysis; D015335:Molecular Probes; D008969:Molecular Sequence Data; D011134:Polysaccharides / Q000032:analysis / Q000737:chemistry* / Q000378:metabolism*; D011485:Protein Binding; D011506:Proteins / Q000032:analysis / Q000737:chemistry* / Q000378:metabolism*
chemical_list: D015335:Molecular Probes; D011134:Polysaccharides; D011506:Proteins; D006493:Heparin; D007785:Lactose