Human pancreatic digestive enzymes.
A primary function of the pancreas is to produce digestive enzymes that are delivered to the small intestine for the hydrolysis of complex nutrients. Much of our understanding of digestive enzymes comes from studies in animals. New technologies and the availability of the sequence of the human genome allow for a critical review of older reports and assumptions based on animal studies. This report updates our understanding of human pancreatic digestive enzymes with a focus on new insights into the biology of human proteases, lipases and amylases.
Whitcomb
David C
DC
Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. whitcomb@dom.pitt.edu
Lowe
Mark E
ME
D000681:Amylases / Q000502:physiology*; D000818:Animals; D002919:Chymotrypsinogen / Q000502:physiology; D003089:Colipases / Q000502:physiology; D004063:Digestion / Q000502:physiology*; D006801:Humans; D006868:Hydrolysis; D008049:Lipase / Q000502:physiology*; D010179:Pancreas / Q000201:enzymology*; D010196:Pancreatic Elastase / Q000502:physiology; D010447:Peptide Hydrolases / Q000502:physiology*; D012697:Serine Endopeptidases / Q000502:physiology; D014357:Trypsin / Q000502:physiology; D014362:Trypsinogen / Q000502:physiology; D000516:alpha-Amylases / Q000502:physiology
D003089:Colipases; D014362:Trypsinogen; D002919:Chymotrypsinogen; D008049:Lipase; D000681:Amylases; D000516:alpha-Amylases; D010447:Peptide Hydrolases; D012697:Serine Endopeptidases; D010196:Pancreatic Elastase; D014357:Trypsin