title: [Radiosurgery for pituitary adenomas].
abstract: Pituitary adenomas represent nearly 15% of all intracranial tumors. Multimodal treatment includes microsurgery, medical management and radiotherapy. Microsurgery is the primary recommendation for nonfunctioning and most of functioning adenomas, except for prolactinomas that are usually managed with dopamine agonist drugs. However, about 30% of patients require additional treatment after microsurgery for recurrent or residual tumors. In these cases, fractionated radiation therapy has been the traditional treatment. More recently, radiosurgery has been established as a treatment option. Radiosurgery allows the delivery of prescribed dose with high precision strictly to the target and spares the surrounding tissues. Therefore, the risks of hypopituitarism, visual damage and vasculopathy are significantly lower. Furthermore, the latency of the radiation response after radiosurgery is substantially shorter than that of fractionated radiotherapy. The goal of this review is to define the efficacy, safety and role of radiosurgery for treatment of pituitary adenomas and to present the preliminary results of our institution.
authors.affiliation: Instituto de Radiocirurgia Neurológica, São Paulo, SP. dougguedes@uol.com.br
authors.forename: Douglas Guedes
authors.initials: DG
authors.lastname: de Castro
authors.forename: João Victor
authors.initials: JV
authors.lastname: Salvajoli
authors.forename: Miguel Montes
authors.initials: MM
authors.lastname: Canteras
authors.forename: Soraya A Jorge
authors.initials: SA
authors.lastname: Cecílio
mesh_terms: D000172:Acromegaly / Q000601:surgery; D000236:Adenoma / Q000601:surgery*; D003480:Cushing Syndrome / Q000601:surgery; D006801:Humans; D010911:Pituitary Neoplasms / Q000601:surgery*; D016634:Radiosurgery / Q000009:adverse effects / Q000295:instrumentation / Q000592:standards*; D016896:Treatment Outcome