title: ELAVL4, PARK10, and the Celts.
abstract: Genetic variability in ELAVL4 located in the PARK10 locus was recently associated with age-at-onset (AAO) in a series of Parkinson's disease (PD) patients originating from the United States. We examined five markers spanning ELAVL4 in Norwegian, United States, and Irish PD case-control samples. No association was found between the examined markers and AAO or PD in Norwegian or US samples. However, ELAVL4 markers (rs967582 and rs3902720) were significantly associated with susceptibility to PD in our Irish series. Our data suggest that the association between ELAVL4 and PD previously observed might be explained by a Celtic-founder effect.
authors.affiliation: Department of Neuroscience and Neurology, Mayo Clinic College of Medicine, Jacksonville, Florida, USA. haugarvoll.kristoffer@mayo.edu
authors.forename: Kristoffer
authors.initials: K
authors.lastname: Haugarvoll
authors.forename: Mathias
authors.initials: M
authors.lastname: Toft
authors.forename: Owen A
authors.initials: OA
authors.lastname: Ross
authors.forename: Jeremy T
authors.initials: JT
authors.lastname: Stone
authors.forename: Michael G
authors.initials: MG
authors.lastname: Heckman
authors.forename: Linda R
authors.initials: LR
authors.lastname: White
authors.forename: Timothy
authors.initials: T
authors.lastname: Lynch
authors.forename: John Mark
authors.initials: JM
authors.lastname: Gibson
authors.forename: Zbigniew K
authors.initials: ZK
authors.lastname: Wszolek
authors.forename: Ryan J
authors.initials: RJ
authors.lastname: Uitti
authors.forename: Jan O
authors.initials: JO
authors.lastname: Aasly
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Farrer
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D051959:ELAV Proteins / Q000235:genetics*; D000067779:ELAV-Like Protein 4; D005260:Female; D008040:Genetic Linkage / Q000235:genetics; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D006801:Humans; D000071158:Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; D008297:Male; D008875:Middle Aged; D009664:Norway / Q000208:ethnology; D010300:Parkinson Disease / Q000208:ethnology* / Q000235:genetics*; D017354:Point Mutation / Q000235:genetics; D017346:Protein Serine-Threonine Kinases / Q000235:genetics; D044767:Ubiquitin-Protein Ligases / Q000235:genetics*; D014481:United States
chemical_list: D051959:ELAV Proteins; D000067779:ELAV-Like Protein 4; C498010:ELAVL4 protein, human; D005819:Genetic Markers; D044767:Ubiquitin-Protein Ligases; C111567:parkin protein; C495280:LRRK2 protein, human; D000071158:Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; D017346:Protein Serine-Threonine Kinases