Sesame oil attenuates Cisplatin-induced hepatic and renal injuries by inhibiting nitric oxide-associated lipid peroxidation in mice.
Although cisplatin (cis-diamminedichloroplatinum) is an effective drug for the treatment of several solid tumors and has been used therapeutically for decades, several cisplatin-induced side effects have limited its therapeutic dosage in clinical studies. Our aim was to examine the effect of sesame oil on cisplatin-induced hepatic and renal injuries in mice (8-week-old female SPF C57BL/6) given subcutaneous cisplatin (0, 5, 10, or 20 mg/kg). Hepatic and renal functions, lipid peroxidation (LPO) levels, and reactive oxygen free radicals were evaluated 3 days after cisplatin administration, and tumor volumes were recorded 0, 3, 6, and 9 days after cisplatin administration. Sesame oil (i) potently attenuated cisplatin-associated hepatic and renal injuries; (ii) decreased cisplatin-initiated LPO as well as the production of hydroxyl radical, peroxynitrite, and nitrite in blood and tissue; and (iii) did not affect the antitumor capacity exerted by cisplatin in mice with melanoma. We suggest that sesame oil attenuates cisplatin-induced hepatic and renal damage by at least partially inhibiting nitric oxide-associated LPO in mice. Sesame oil might be a new approach for preventing cisplatin-induced multiple organ injury during the treatment of tumors.
Hsu
Dur-Zong
DZ
Department of Environmental and Occupational Health, National Cheng Kung University Medical College, Tainan, Taiwan.
Chen
Ke-Ting
KT
Lin
Ta-Hsing
TH
Li
Ya-Hui
YH
Liu
Ming-Yie
MY
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use / Q000633:toxicity*; D002945:Cisplatin / Q000627:therapeutic use / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D005260:Female; D007668:Kidney / Q000293:injuries / Q000378:metabolism* / Q000473:pathology; D015227:Lipid Peroxidation / Q000187:drug effects*; D008099:Liver / Q000293:injuries / Q000378:metabolism* / Q000473:pathology; D008545:Melanoma / Q000188:drug therapy; D051379:Mice; D009569:Nitric Oxide / Q000378:metabolism*; D010084:Oxidation-Reduction / Q000187:drug effects; D017382:Reactive Oxygen Species / Q000378:metabolism; D012715:Sesame Oil / Q000494:pharmacology*
D000970:Antineoplastic Agents; D017382:Reactive Oxygen Species; D009569:Nitric Oxide; D012715:Sesame Oil; D002945:Cisplatin