title: Genetic diversity of 10 X chromosome STRs in northern Portugal.
abstract: Genetic data of 10 X chromosome STRs (DXS8378, DXS9898, DXS8377, HPRTB, GATA172D05, DXS7423, DXS6809, DXS7132, DXS101 and DXS6789) were obtained in a sample of unrelated males born in the five northern Portuguese districts. In a global sample of 347 individuals, no shared haplotypes were found for this set of markers and single locus gene diversities were high, varying between 0.678 for DXS7423 and 0.921 for DXS8377. Linkage disequilibrium analysis did not reveal consistent evidence of association between the X-STRs used. Population comparisons of northern Portuguese districts (exact test of population differentiation; pairwise genetic distances) and analysis of molecular variance supported genetic homogeneity of this region and therefore a common genetic database was considered. In comparisons with other European data, the only population samples showing statistically significant differences to northern Portugal were Germany and Latvia. The present work demonstrates that these genetic markers are highly discriminating and therefore useful for human identification purposes and anthropological research.
authors.affiliation: Instituto de Patologia e Imunologia Molecular da Universidade do Porto, Rua Dr. Roberto Frias, Portugal. lgusmao@ipatimup.pt
authors.forename: Rui
authors.initials: R
authors.lastname: Pereira
authors.forename: Iva
authors.initials: I
authors.lastname: Gomes
authors.forename: António
authors.initials: A
authors.lastname: Amorim
authors.forename: Leonor
authors.initials: L
authors.lastname: Gusmão
mesh_terms: D041321:Chromosomes, Human, X; D016172:DNA Fingerprinting; D005787:Gene Frequency; D014644:Genetic Variation; D005828:Genetics, Population; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D011174:Portugal; D020080:Tandem Repeat Sequences