Cerebral oxidative metabolism in rats with high and low exploratory activity.
To reveal brain regions most significantly related to individual differences in exploratory behaviour, oxidative metabolism was measured by cytochrome c oxidase histochemistry in 2 months old Wistar rats with persistently high (HE) or low (LE) exploratory activity in a novel environment. LE-rats had significantly higher levels of oxidative metabolism in dorsal raphe and inferior colliculi. In contrast, HE-rats had higher metabolic activity in entorhinal cortex. In conclusion, rats with different exploratory styles differ in underlying cerebral activity as measured via oxidative metabolism in regions implicated in defensive behaviours and cognitive processing of sensory stimuli.
Matrov
Denis
D
Department of Psychology, Centre of Behavioural and Health Sciences, University of Tartu, Tiigi 78, EE-50410 Tartu, Estonia.
Kolts
Ivo
I
Harro
Jaanus
J
D000818:Animals; D001522:Behavior, Animal / Q000502:physiology; D002540:Cerebral Cortex / Q000378:metabolism*; D003071:Cognition / Q000502:physiology; D003576:Electron Transport Complex IV / Q000032:analysis / Q000378:metabolism; D004734:Energy Metabolism / Q000502:physiology*; D005106:Exploratory Behavior / Q000502:physiology*; D005239:Fear / Q000502:physiology; D007245:Inferior Colliculi / Q000033:anatomy & histology / Q000378:metabolism; D008297:Male; D010085:Oxidative Phosphorylation; D010101:Oxygen Consumption / Q000502:physiology*; D010465:Perception / Q000502:physiology; D011903:Raphe Nuclei / Q000033:anatomy & histology / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
D003576:Electron Transport Complex IV