title: Synthesis of a library of 2-alkyl-3-alkyloxy-2H-indazole-6-carboxamides.
abstract: A library of 200 2-alkyl-3-alkyloxy-2H-indazole-6-carboxamides was synthesized using parallel solution-phase methods. The indazole cyclization reaction was optimized for library production with the best yields resulting from controlled alcohol/water solvent ratios. The key step, a heterocyclization reaction, proceeds by N,N-bond formation and delivers the 2H-indazole scaffold. Automated preparative HPLC was utilized to provide pure compounds on a 10+ mg scale.
authors.affiliation: Department of Chemistry, University of California, One Shields Avenue, Davis, California 95616-5295, USA.
authors.forename: Aaron D
authors.initials: AD
authors.lastname: Mills
authors.forename: Patrick
authors.initials: P
authors.lastname: Maloney
authors.forename: Elsayed
authors.initials: E
authors.lastname: Hassanein
authors.forename: Makhluf J
authors.initials: MJ
authors.lastname: Haddadin
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Kurth
mesh_terms: D000577:Amides / Q000138:chemical synthesis*; D002853:Chromatography, Liquid; D020650:Combinatorial Chemistry Techniques / Q000379:methods; D007191:Indazoles / Q000138:chemical synthesis*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D015394:Molecular Structure; D009579:Nitrobenzoates / Q000737:chemistry*
chemical_list: D000577:Amides; D007191:Indazoles; D009579:Nitrobenzoates; C075153:4-bromomethyl-3-nitrobenzoic acid