The effect of acetaminophen on the crystal growth of calcium carbonate.
The effect of acetaminophen, a well known analgesic and fever-reducing medicine, on the calcium carbonate crystal growth was investigated under plethostatic conditions. The calcification rates measured was reduced by 9.1-63.2% in the presence of acetaminophen. Kinetic analysis according to a Langmuir-type adsorption isotherm lead to the calculation of an affinity constant K (aff) = 8.33 x 10(2 )dm(3 )mol(-1). The apparent order found from kinetic data was two suggesting a surface diffusion controlled spiral growth mechanism.
Malkaj
P
P
Department of Chemistry, University of Patras, Patras, Greece.
Dalas
E
E
D000082:Acetaminophen / Q000737:chemistry* / Q000494:pharmacology*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000494:pharmacology; D001672:Biocompatible Materials / Q000737:chemistry; D002114:Calcinosis / Q000188:drug therapy; D002119:Calcium Carbonate / Q000737:chemistry*; D003460:Crystallization; D006801:Humans; D066298:In Vitro Techniques; D007700:Kinetics; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning
D000894:Anti-Inflammatory Agents, Non-Steroidal; D001672:Biocompatible Materials; D000082:Acetaminophen; D002119:Calcium Carbonate