title: Reassessment of the 1993 Osaka grading system for localized soft tissue sarcoma in Japan.
abstract: BACKGROUND
  The Osaka system for soft-tissue sarcoma grading was proposed through an analysis of soft-tissue sarcoma (STS), treated from 1964 to 1989. The present study was conducted to evaluate the utility of the Osaka system under recent therapeutic regimens.
  
  
  METHODS
  One hundred and eleven patients with localized STSs arising in the trunk and extremities (66 males and 45 females; median age 57) were selected. Histological factors, argyrophilic nucleolar organizer region (AgNOR) count and Ki-67 labeling index (LI) were evaluated for prognostic significance.
  
  
  RESULTS
  Univariate analysis revealed that histological classification, mitotic count, cellularity, AgNOR count, and Ki-67 LI were prognostically significant for survival. Multivariate analysis revealed Ki-67 LI as an independent prognostic factor. The five-year survival rate for low-, intermediate-, and high-grade STSs in Osaka grading was 94.6%, 75.2%, and 68.4%, respectively.
  
  
  CONCLUSIONS
  Osaka grading is a useful system for the decision-making of therapeutic modalities for STS.
authors.affiliation: Department of Pathology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan. yt@molpath.med.osaka-u.ac.jp
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Tomita
authors.forename: Takaya
authors.initials: T
authors.lastname: Morooka
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Hoshida
authors.forename: Binglin
authors.initials: B
authors.lastname: Zhang
authors.forename: Ying
authors.initials: Y
authors.lastname: Qiu
authors.forename: Itsuko
authors.initials: I
authors.lastname: Nakamichi
authors.forename: Kenichiro
authors.initials: K
authors.lastname: Hamada
authors.forename: Takafumi
authors.initials: T
authors.lastname: Ueda
authors.forename: Norifumi
authors.initials: N
authors.lastname: Naka
authors.forename: Ikuo
authors.initials: I
authors.lastname: Kudawara
authors.forename: Katsuyuki
authors.initials: K
authors.lastname: Aozasa
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis; D012509:Sarcoma / Q000473:pathology*; D012720:Severity of Illness Index