title: Sprint training reduces urinary purine loss following intense exercise in humans.
abstract: The influence of sprint training on endogenous urinary purine loss was examined in 7 active male subjects (age, 23.1 +/- 1.8 y; body mass, 76.1 +/- 3.1 kg; VO2 peak, 56.3 +/- 4.0 mL.kg-1.min-1). Each subject performed a 30 s sprint performance test (PT), before and after 7 d of sprint training. Training consisted of 15 sprints, each lasting 10 s, on an air-braked cycle ergometer performed twice each day. A rest period of 50 s separated each sprint during training. Sprint training resulted in a 20% higher muscle ATP immediately after PT, a lower IMP (57% and 89%, immediately after and 10 min after PT, respectively), and inosine accumulation (53% and 56%, immediately after and 10 min after the PT, respectively). Sprint training also attenuated the exercise-induced increases in plasma inosine, hypoxanthine (Hx), and uric acid during the first 120 min of recovery and reduced the total urinary excretion of purines (inosine + Hx + uric acid) in the 24 h recovery period following intense exercise. These results show that intermittent sprint training reduces the total urinary purine excretion after a 30 s sprint bout.
authors.affiliation: Exercise Metabolism Unit, Centre for Ageing, Rehabilitation and Exercise and Sport, Victoria University, Footscray, 3011, Australia.
authors.forename: Christos G
authors.initials: CG
authors.lastname: Stathis
authors.forename: Michael F
authors.initials: MF
authors.lastname: Carey
authors.forename: Alan
authors.initials: A
authors.lastname: Hayes
authors.forename: Andrew P
authors.initials: AP
authors.lastname: Garnham
authors.forename: Rodney J
authors.initials: RJ
authors.lastname: Snow
mesh_terms: D000328:Adult; D006801:Humans; D019271:Hypoxanthine / Q000097:blood / Q000652:urine; D007288:Inosine / Q000097:blood / Q000652:urine; D008297:Male; D009132:Muscles / Q000378:metabolism; D009994:Osmolar Concentration; D010806:Physical Education and Training; D011687:Purines / Q000652:urine*; D012420:Running; D013997:Time Factors; D014527:Uric Acid / Q000097:blood / Q000652:urine
chemical_list: D011687:Purines; D014527:Uric Acid; D019271:Hypoxanthine; D007288:Inosine