title: Metabolism of linoleic acid by human gut bacteria: different routes for biosynthesis of conjugated linoleic acid.
abstract: A survey of 30 representative strains of human gram-positive intestinal bacteria indicated that Roseburia species were among the most active in metabolizing linoleic acid (cis-9,cis-12-18:2). Different Roseburia spp. formed either vaccenic acid (trans-11-18:1) or a 10-hydroxy-18:1; these compounds are precursors of the health-promoting conjugated linoleic acid cis-9,trans-11-18:2 in human tissues and the intestine, respectively.
authors.affiliation: Rowett Research Institute, Bucksburn, Aberdeen, AB21 9SB, United Kingdom.
authors.forename: Estelle
authors.initials: E
authors.lastname: Devillard
authors.forename: Freda M
authors.initials: FM
authors.lastname: McIntosh
authors.forename: Sylvia H
authors.initials: SH
authors.lastname: Duncan
authors.forename: R John
authors.initials: RJ
authors.lastname: Wallace
mesh_terms: D000328:Adult; D006094:Gram-Positive Bacteria / Q000145:classification / Q000201:enzymology* / Q000378:metabolism; D006801:Humans; D007223:Infant; D007420:Intestine, Large / Q000382:microbiology*; D007535:Isomerases / Q000378:metabolism; D008041:Linoleic Acids / Q000378:metabolism*; D044243:Linoleic Acids, Conjugated / Q000096:biosynthesis*
chemical_list: D008041:Linoleic Acids; D044243:Linoleic Acids, Conjugated; D007535:Isomerases