title: Platinum(II)-catalyzed cyclizations forming quaternary carbon centers, using enesulfonamides, enecarbamates, or enamides as nucleophiles.
abstract: Cyclic enesulfonamides, enecarbamates, or enamides tethered to an alkyne cyclize readily with use of platinum(II) chloride. This reaction generates quaternary-substituted carbon centers within simple spiro-fused or more complex tri- and tetracyclic heterocyclic ring systems. The yields for this process range from 50% to 83%. [reaction: see text].
authors.affiliation: Department of Chemistry, 2036 Main Mall, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z1.
authors.forename: Tyler J
authors.initials: TJ
authors.lastname: Harrison
authors.forename: Brian O
authors.initials: BO
authors.lastname: Patrick
authors.forename: Gregory R
authors.initials: GR
authors.lastname: Dake
mesh_terms: D000475:Alkenes / Q000138:chemical synthesis* / Q000737:chemistry; D000480:Alkynes / Q000737:chemistry*; D000577:Amides / Q000737:chemistry*; D002219:Carbamates / Q000737:chemistry*; D002244:Carbon / Q000737:chemistry; D002384:Catalysis; D003500:Cyclization; D015394:Molecular Structure; D017671:Platinum Compounds / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000475:Alkenes; D000480:Alkynes; D000577:Amides; D002219:Carbamates; D017671:Platinum Compounds; C030173:platinum chloride; D002244:Carbon