title: Acute myeloid leukemia (AML-M2) with t(5;11)(q35;q13) and normal expression of cyclin D1.
abstract: We report a case of acute myeloid leukemia (AML) subtype M2, with t(5;11)(q35;q13), in a 30-year-old man. Conventional cytogenetic, spectral karyotyping, and fluorescence in situ hybridization (FISH) studies on bone marrow sample obtained at diagnosis revealed an abnormal karyotype in all cells examined. FISH analysis demonstrated absence of translocations in the region of the cyclin D1 gene and real-time quantitative reverse transcriptase-polymerase chain reaction revealed normal expression of this gene. Similar to the 11q23 region, 11q13 changes can be found in both myeloid and lymphoid neoplasias with different chromosomes serving as donors in translocations.
authors.affiliation: Departamento de Genética, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Av. Bandeirantes, 3900, 14049-900 Ribeirão Preto, SP, Brazil.
authors.forename: Fábio Morato
authors.initials: FM
authors.lastname: de Oliveira
authors.forename: Luiz Gonzaga
authors.initials: LG
authors.lastname: Tone
authors.forename: Belinda Pinto
authors.initials: BP
authors.lastname: Simões
authors.forename: Roberto Passetto
authors.initials: RP
authors.lastname: Falcão
authors.forename: María Sol
authors.initials: MS
authors.lastname: Brassesco
authors.forename: Elza Tiemi
authors.initials: ET
authors.lastname: Sakamoto-Hojo
authors.forename: Guilherme Augusto Silva
authors.initials: GA
authors.lastname: dos Santos
authors.forename: André Fiorin
authors.initials: AF
authors.lastname: Marinato
authors.forename: Rafael Henriques
authors.initials: RH
authors.lastname: Jácomo
authors.forename: Eduardo Magalhães
authors.initials: EM
authors.lastname: Rego
mesh_terms: D000328:Adult; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics*; D002895:Chromosomes, Human, Pair 5 / Q000235:genetics*; D019938:Cyclin D1 / Q000096:biosynthesis* / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics* / Q000378:metabolism; D015479:Leukemia, Myelomonocytic, Acute; D008297:Male; D014178:Translocation, Genetic
chemical_list: D019938:Cyclin D1