Mahogany, blood-brain barrier, and fat mass surge in AVY mice.
Avy/agouti (Avy) mice have late onset obesity related to overexpression of agouti signaling protein (ASP) in the hypothalamus. As mahogany modulates the actions of ASP, we tested the transport of mahogany peptide across the blood-brain barrier (BBB). The brain uptake of mahogany peptide was significantly higher in young Avy mice, and it preceded the surge of fat mass quantified by nuclear magnetic resonance. The results suggest a role of accelerated BBB transport in the epigenetics of Avy mice.
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Blood-Brain Barrier Lab, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA. weihong.pan@pbrc.edu
Kastin
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AJ
D000273:Adipose Tissue / Q000378:metabolism*; D054366:Agouti Signaling Protein; D000818:Animals; D001692:Biological Transport / Q000502:physiology; D001812:Blood-Brain Barrier / Q000378:metabolism*; D001921:Brain / Q000378:metabolism; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism; D008279:Magnetic Resonance Imaging; D008565:Membrane Proteins / Q000493:pharmacokinetics*; D051379:Mice; D008817:Mice, Mutant Strains; D009765:Obesity / Q000378:metabolism
D054366:Agouti Signaling Protein; C117928:Atrn protein, mouse; D036341:Intercellular Signaling Peptides and Proteins; D008565:Membrane Proteins