Ethanolic Zingiber officinale R. extract pretreatment alleviates isoproterenol-induced oxidative myocardial necrosis in rats.
Ethanolic Z. officinale (ZO) extract (200 mg/kg) pretreatment for 20 days in isoproterenol (ISO)-treated rats significantly increased the levels of endogenous myocardial antioxidants (catalase, superoxide dismutase and tissue glutathione), decreased the levels of serum marker enzymes (lactate dehydrogenase, creatine kinase, aspartate transaminase and alanine transaminase) and increased myocardial lipid peroxides. Histological examination of rat's heart section confirmed myocardial injury with ISO administration and near normal pattern with ethanolic ZO extract pretreatment. The results of the present study, for the first time, provide clear evidence that the ethanolic ZO extract pretreatment enhances the antioxidant defense against ISO-induced oxidative myocardial injury in rats and exhibit cardioprotective property.
Ansari
M Nazam
MN
Department of Pharmacology, Faculty of Pharmacy, Jamia Hamdard, New Delhi 110 062, India.
Bhandari
U
U
Pillai
K K
KK
D000818:Animals; D000975:Antioxidants / Q000032:analysis; D015415:Biomarkers / Q000097:blood; D000431:Ethanol / Q000494:pharmacology; D005260:Female; D020939:Zingiber officinale / Q000737:chemistry*; D007545:Isoproterenol; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D009203:Myocardial Infarction / Q000139:chemically induced / Q000188:drug therapy*; D009206:Myocardium / Q000473:pathology; D009336:Necrosis / Q000188:drug therapy; D010936:Plant Extracts / Q000494:pharmacology* / Q000627:therapeutic use; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D012997:Solvents / Q000494:pharmacology
D000975:Antioxidants; D015415:Biomarkers; D010936:Plant Extracts; D012997:Solvents; D000431:Ethanol; D007545:Isoproterenol