title: [Not significant--what now?].
abstract: In a statistical significance test a scientific problem is expressed by formulating a null hypothesis and an opposite alternative. Construction of an empirical decision rule usually focuses on control of the alpha-error, i.e. the probability of erroneously refusing the null hypothesis. Contrary to the alpha-error, the beta-error is not controlled and in general is of unknown size. Thus in case of a non-significant result the validity of the null hypothesis still may be highly questionable. Such an unwanted outcome of an applied test the researcher should try to avoid by choosing an appropriate study design. In case it occurs nevertheless, it is advised to further evaluate the (non-significant) result. This can be done by calculating confidence intervals of the tested effects. Furthermore the p-value can be interpreted as a metric measure of evidence against the null hypothesis. By means of a posterior power analysis the probability of a significant test result is estimated under the given circumstances. Thus possibly the applied test--under the assumption of actual validity of the alternative--turns out to have had hardly a chance of rejecting the null hypothesis. In this case the non-significant result (pointing towards the null hypothesis) is relativized substantially. On the other hand a large power points to a small probability of a beta-error.
authors.affiliation: Universität Münster, Institut für Medizinische Informatik und Biomathematik, Münster, Germany. joachim.gerss@ukmuenster.de
authors.forename: J
authors.initials: J
authors.lastname: Gerss
mesh_terms: D011336:Probability; D015203:Reproducibility of Results; D012107:Research Design / Q000592:standards*; D012586:Science / Q000379:methods* / Q000592:standards*