Increase in soluble CD138 in bronchoalveolar lavage fluid of multicentric Castleman's disease.
Multicentric Castleman's disease (MCD) is a rare and often incurable lymphoproliferative disorder. It is typically a systemic illness, but occasionally manifests primarily as a pulmonary parenchymal disease with massive infiltration of CD138 (syndecan-1)-positive plasma cells. This is the first report to demonstrate a marked elevation of soluble CD138, despite the absence of plasma cells, in BAL fluid in an MCD patient with pulmonary involvement. This finding suggests that the quantitative measurement of soluble CD138 in BAL fluid may reflect plasma cell infiltration and disease activity in the lungs of patients with MCD.
Hasegawa
Masaru
M
First Department of Medicine, Hokkaido University School of Medicine, Sapporo, Japan.
Betsuyaku
Tomoko
T
Yoshida
Nobuya
N
Nasuhara
Yasuyuki
Y
Kinoshita
Ichiro
I
Ohta
Satoshi
S
Itoh
Tomoo
T
Park
Pyong Woo
PW
Nishimura
Masaharu
M
D015415:Biomarkers / Q000378:metabolism; D001707:Biopsy, Needle; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry* / Q000166:cytology; D005871:Castleman Disease / Q000150:complications / Q000175:diagnosis / Q000378:metabolism*; D002452:Cell Count; D003937:Diagnosis, Differential; D018450:Disease Progression; D005500:Follow-Up Studies; D006801:Humans; D007668:Kidney / Q000473:pathology; D017563:Lung Diseases, Interstitial / Q000150:complications / Q000175:diagnosis / Q000378:metabolism*; D008198:Lymph Nodes / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010950:Plasma Cells; D035583:Rare Diseases; D012720:Severity of Illness Index; D053668:Syndecan-1 / Q000378:metabolism*; D014057:Tomography, X-Ray Computed
D015415:Biomarkers; C508241:SDC1 protein, human; D053668:Syndecan-1