Hepcidin the link between inflammation and anemia in chronic renal failure.
A chronic inflammatory state characterized the patients with chronic renal failure. The causes of this situation are multiple and inter-connected. The break of the equilibrium between pro-inflammatory agents and anti-inflammatory ones in haemodialysis patients leads to anemia of chronic inflammation, characterized by a functional iron deficiency. Very recently it was discovered a peptide produced by the liver, named hepcidin, that provides a good link between inflammation and metabolism of iron, rendering more understandable the interdependence of inflammation and anemia.
Atanasiu
V
V
Faculty of Medicine, Department of Medical Biochemistry, Carol Davila University of Medicine and Pharmacy. atanasis2003@yahoo.com
Manolescu
B
B
Stoian
Irina
I
D000740:Anemia / Q000378:metabolism; D023181:Antimicrobial Cationic Peptides / Q000378:metabolism*; D064451:Hepcidins; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D007501:Iron / Q000378:metabolism; D007676:Kidney Failure, Chronic / Q000378:metabolism / Q000503:physiopathology
D023181:Antimicrobial Cationic Peptides; C578702:HAMP protein, human; D064451:Hepcidins; D007501:Iron