Selective defect in plasmacyoid dendritic cell function in a patient with AIDS-associated atypical genital herpes simplex vegetans treated with imiquimod.
We report a case of acquired immunodeficiency syndrome (AIDS)-associated, acyclovir-refractory genital herpes infection treated with topical imidazoquinoline therapy. The patient's plasmacytoid dendritic cells made a robust interferon- alpha response following in vitro stimulation with imidazoquinoline but not with herpes simplex virus. We hypothesize that disease resulting from defective herpes simplex virus-stimulated interferon- alpha may be overcome by stimulating intact alternative pathways.
Abbo
Lillian
L
The Miami Veterans Administration Medical Center, Miami, FL, USA.
Vincek
Vladimir
V
Dickinson
Gordon
G
Shrestha
Niraj
N
Doblecki
Susanne
S
Haslett
Patrick A J
PA
D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy / Q000821:virology; D000212:Acyclovir / Q000494:pharmacology; D000328:Adult; D000634:Aminoquinolines / Q000627:therapeutic use*; D000998:Antiviral Agents / Q000494:pharmacology; D003713:Dendritic Cells / Q000473:pathology*; D015658:HIV Infections / Q000150:complications / Q000276:immunology*; D015497:HIV-1 / Q000276:immunology; D006558:Herpes Genitalis / Q000188:drug therapy*; D018258:Herpesvirus 2, Human / Q000187:drug effects; D006801:Humans; D000077271:Imiquimod; D007369:Interferon Inducers / Q000627:therapeutic use*; D008297:Male
D000634:Aminoquinolines; D000998:Antiviral Agents; D007369:Interferon Inducers; D000077271:Imiquimod; D000212:Acyclovir