DNA nucleoside interaction and identification with carbon nanotubes.
We investigate the interaction of individual DNA nucleosides with a carbon nanotube (CNT) in vacuum and in the presence of external gate voltage. We propose a scheme to discriminate between nucleosides on CNTs based on measurement of electronic features through a local probe such as scanning tunneling spectroscopy. We demonstrate through quantum mechanical calculations that these measurements can achieve 100% efficiency in identifying DNA bases. Our results support the practicality of ultrafast DNA sequencing using electrical measurements.
Meng
Sheng
S
Department of Physics and Division of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts 02138, USA.
Maragakis
Paul
P
Papaloukas
Costas
C
Kaxiras
Efthimios
E
D004247:DNA / Q000737:chemistry*; D037742:Nanotubes, Carbon / Q000737:chemistry*; D009705:Nucleosides / Q000737:chemistry*; D013057:Spectrum Analysis / Q000379:methods*
D037742:Nanotubes, Carbon; D009705:Nucleosides; D004247:DNA