title: [Effectiveness and safety of the treatment of menopausal syndrome with Cimicifuga racemosa dry extract].
abstract: OBJECTIVE
  Phytoestrogens could be an alternative method of the treatment of menopausal syndrome in women with contraindications to hormonal replacement therapy.
  
  
  METHODS
  The aim of the study was to evaluate efficacy and safety of the therapy with Cimicifuga racemosa dry extract.
  
  
  METHODS
  Twenty women aged mean 52.4 +/- 4.9 years with climacteric syndrome were treated with Cimicifuga racemosa dry extract in a dose of 40 mg a day during 6 months. Kupperman's Index, biochemical parameters and hormonal profile were estimated before and after 3 and 6 months of the therapy.
  
  
  RESULTS
  Mean values of Kuppermen's Index were decreased from 30.2 +/- 5.7 points before the therapy to 8.5 +/- 6.3 points after 3 months and to 2.6 +/- 2.1 points after 6 months of the therapy (p < 0.05). No statistical differences in biochemical parameters' concentrations and hormonal profile were observed.
  
  
  CONCLUSIONS
  Cimicifuga racemosa dry extract was an effective and safe therapy of climacteric women with contraindications to hormonal replacement therapy.
authors.affiliation: Klinika Endokrynologii Ginekologicznej Akademii Medycznej w Warszawie.
authors.forename: Stanisław
authors.initials: S
authors.lastname: Radowicki
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Skórzewska
authors.forename: Ewa
authors.initials: E
authors.lastname: Rudnicka
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Szlendak-Sauer
authors.forename: Waldemar
authors.initials: W
authors.lastname: Wierzba
mesh_terms: D031885:Cimicifuga; D004305:Dose-Response Relationship, Drug; D005260:Female; D019584:Hot Flashes / Q000188:drug therapy*; D006801:Humans; D008593:Menopause / Q000187:drug effects*; D008875:Middle Aged; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage; D011044:Poland; D011446:Prospective Studies; D018709:Statistics, Nonparametric; D016896:Treatment Outcome; D016387:Women's Health
chemical_list: D010936:Plant Extracts