Droplets as microreactors for high-throughput biology.
Inspired by the principles of biological evolution, biologists--and others--have in recent decades harnessed the power of "natural" selection to sift through huge libraries of genes and find those with desirable properties. At the same time, the demand for high-throughput biochemical and genetic assays and screens has driven the development of increasingly miniaturised assay systems. An exciting synergy is now emerging between these two fields, whereby the tools of ultrahigh-throughput screening promise to open up new directions in molecular engineering.
Taly
Valerie
V
Medical Research Council, Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK.
Kelly
Bernard T
BT
Griffiths
Andrew D
AD
D001419:Bacteria / Q000235:genetics; D019149:Bioreactors; D002384:Catalysis; D019020:Directed Molecular Evolution; D004655:Emulsions / Q000737:chemistry*; D005434:Flow Cytometry; D015723:Gene Library; D008832:Microchemistry; D008967:Molecular Biology / Q000379:methods*
D004655:Emulsions