title: Angiography of primary central nervous system angiitis of childhood: conventional angiography versus magnetic resonance angiography at presentation.
abstract: OBJECTIVE
  To systematically analyze conventional angiographic (CA) features of children with primary central nervous system angiitis (cPACNS), to compare and correlate CA and MR angiography (MRA) lesion characteristics, and to define the sensitivity and specificity of MRA with CA as a reference standard.
  
  
  METHODS
  A retrospective, single-center cohort study of consecutive patients with cPACNS was performed. Patients with CA and MRA studies at diagnosis were included. Imaging studies were blindly reviewed by 2 neuroradiologists using a standard analysis protocol. CA and MRA studies were compared using nonparametric analysis.
  
  
  RESULTS
  Of 45 patients with MRA at diagnosis, there were 25 for whom CA and MRA studies were performed within 1 month of each other. These comprised the study group. The CA distribution of lesions was multifocal (76%) and proximal (86%) (P < .05) with a trend toward unilaterality (P = .06) with anterior circulation involvement (P = .08). The sensitivity and specificity of MRA for CA abnormality was 70% and 98%, respectively. There was no significant difference between MRA and CA for lesion detection or characterization (P = .87), and the modalities showed a fair correlation (kappa = 0.4).
  
  
  CONCLUSIONS
  Angiographic lesions are multifocal and occur proximally and unilaterally within the anterior circulation. There is no significant difference in the ability of MRA to detect and characterize lesions when compared with CA.
authors.affiliation: Division of Neuroradiology, Hospital for Sick Children, Toronto, Ontario, Canada. richardaviv@lineone.net
authors.forename: R I
authors.initials: RI
authors.lastname: Aviv
authors.forename: S M
authors.initials: SM
authors.lastname: Benseler
authors.forename: G
authors.initials: G
authors.lastname: DeVeber
authors.forename: E D
authors.initials: ED
authors.lastname: Silverman
authors.forename: P N
authors.initials: PN
authors.lastname: Tyrrell
authors.forename: L M
authors.initials: LM
authors.lastname: Tsang
authors.forename: D
authors.initials: D
authors.lastname: Armstrong
mesh_terms: D000293:Adolescent; D002533:Cerebral Angiography; D002536:Cerebral Arteries / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D003251:Constriction, Pathologic / Q000175:diagnosis; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional; D007223:Infant; D018810:Magnetic Resonance Angiography; D008297:Male; D012680:Sensitivity and Specificity; D013223:Statistics as Topic; D020293:Vasculitis, Central Nervous System / Q000175:diagnosis*