Palladium-catalyzed cross-coupling between vinyl halides and tert-butyl carbazate: first general synthesis of the unusual N-Boc-N-alkenylhydrazines.
N-Boc-N-alkenylhydrazines, an almost unknown type of compounds, have been prepared with high to moderate yields via palladium-catalyzed cross-coupling between alkenyl halides and tert-butyl carbazate. The present methodology represents the first general way to access this highly functionalized and unusual type of hydrazines. [reaction: see text].
Barluenga
José
J
Instituto Universitario de Química OrganometAlica Enrique Moles, Universidad de Oviedo, JuliAn Clavería 8, Oviedo 33006, Spain. barluenga@uniovi.es
Moriel
Patricia
P
Aznar
Fernando
F
Valdés
Carlos
C
D002384:Catalysis; D006834:Hydrazines / Q000138:chemical synthesis* / Q000737:chemistry; D006846:Hydrocarbons, Halogenated / Q000737:chemistry*; D008024:Ligands; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry; D010165:Palladium / Q000737:chemistry*; D013237:Stereoisomerism; D014753:Vinyl Compounds / Q000737:chemistry*
D006834:Hydrazines; D006846:Hydrocarbons, Halogenated; D008024:Ligands; D009942:Organometallic Compounds; D014753:Vinyl Compounds; C518011:tert-butyl carbazate; D010165:Palladium