title: Human pancreatic digestive enzymes.
abstract: A primary function of the pancreas is to produce digestive enzymes that are delivered to the small intestine for the hydrolysis of complex nutrients. Much of our understanding of digestive enzymes comes from studies in animals. New technologies and the availability of the sequence of the human genome allow for a critical review of older reports and assumptions based on animal studies. This report updates our understanding of human pancreatic digestive enzymes with a focus on new insights into the biology of human proteases, lipases and amylases.
authors.affiliation: Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. whitcomb@dom.pitt.edu
authors.forename: David C
authors.initials: DC
authors.lastname: Whitcomb
authors.forename: Mark E
authors.initials: ME
authors.lastname: Lowe
mesh_terms: D000681:Amylases / Q000502:physiology*; D000818:Animals; D002919:Chymotrypsinogen / Q000502:physiology; D003089:Colipases / Q000502:physiology; D004063:Digestion / Q000502:physiology*; D006801:Humans; D006868:Hydrolysis; D008049:Lipase / Q000502:physiology*; D010179:Pancreas / Q000201:enzymology*; D010196:Pancreatic Elastase / Q000502:physiology; D010447:Peptide Hydrolases / Q000502:physiology*; D012697:Serine Endopeptidases / Q000502:physiology; D014357:Trypsin / Q000502:physiology; D014362:Trypsinogen / Q000502:physiology; D000516:alpha-Amylases / Q000502:physiology
chemical_list: D003089:Colipases; D014362:Trypsinogen; D002919:Chymotrypsinogen; D008049:Lipase; D000681:Amylases; D000516:alpha-Amylases; D010447:Peptide Hydrolases; D012697:Serine Endopeptidases; D010196:Pancreatic Elastase; D014357:Trypsin