title: Altered multiaxial mechanical properties of the porcine anterior lens capsule cultured in high glucose.
abstract: Hyperglycemia can alter the mechanical properties of tissues through the formation of advanced glycation endproducts in matrix proteins that have long half-lives. We used a custom experimental system and subdomain finite element method to quantify alterations in the regional multiaxial mechanical properties of porcine lens capsules that were cultured for 8 or 14 weeks in high glucose versus control media. Findings revealed that high glucose significantly stiffened the capsules in both the circumferential and the meridional directions, but it did not affect the known regional variations in anisotropy. Such information could be important in the design of both improved clinical procedures and intraocular implants for diabetic patients.
authors.affiliation: Department of Biomedical Engineering, Texas A&M University, College Station, TX 77843-3120, USA.
authors.forename: R M
authors.initials: RM
authors.lastname: Pedrigi
authors.forename: E
authors.initials: E
authors.lastname: Staff
authors.forename: G
authors.initials: G
authors.lastname: David
authors.forename: S
authors.initials: S
authors.lastname: Glenn
authors.forename: J D
authors.initials: JD
authors.lastname: Humphrey
mesh_terms: D000818:Animals; D016880:Anisotropy; D001696:Biomechanical Phenomena / Q000379:methods; D003198:Computer Simulation; D004548:Elasticity; D005947:Glucose / Q000008:administration & dosage / Q000378:metabolism*; D007903:Lens Capsule, Crystalline / Q000187:drug effects / Q000502:physiology*; D008954:Models, Biological; D009924:Organ Culture Techniques; D013314:Stress, Mechanical; D013552:Swine; D046509:Tissue Culture Techniques
chemical_list: D005947:Glucose