title: Positron emission tomography with F-18 fluorodeoxyglucose in evaluating colorectal hepatic metastasis down-staged by chemotherapy.
abstract: BACKGROUND
  The efficacy of positron emission tomography with 18F fluoro-2-deoxy-D-glucose (FDG-PET) is obscure in evaluating viability or the extent of colorectal hepatic metastasis (CHM), down-staged by chemotherapy.
  
  
  METHODS
  A retrospective lesion-by-lesion analysis was performed for seven consecutive patients, who had received rescue hepatectomy for initially unresectable CHM, in order to evaluate the correlation between results of imaging modalities and the corresponding pathology.
  
  
  RESULTS
  The sensitivity and positive predictive value of the conventional modalities (CT and MRI) were 92% and 42%, respectively, while the sensitivity, specificity, positive predictive value and negative predictive value of FDG-PET were 58%, 100%, 100% and 75% respectively. The sensitivity of FDG-PET was 100% in evaluating the viability of tumors >2 cm, however, this fell to 17% in tumors <2 cm.
  
  
  CONCLUSIONS
  FDG-PET is effective in assessing the viability of tumors >2 cm, but not those <2 cm, in patients with CHM down-staged by chemotherapy.
authors.affiliation: Department of Hepato-biliary Pancreatic Surgery, National Cancer Center Hospital East, Chiba, Japan. shtakaha@east.ncc.go.jp
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Takahashi
authors.forename: Yoshihumi
authors.initials: Y
authors.lastname: Kuroki
authors.forename: Katsuhiro
authors.initials: K
authors.lastname: Nasu
authors.forename: Shigeru
authors.initials: S
authors.lastname: Nawano
authors.forename: Masaru
authors.initials: M
authors.lastname: Konishi
authors.forename: Toshio
authors.initials: T
authors.lastname: Nakagohri
authors.forename: Naoto
authors.initials: N
authors.lastname: Gotohda
authors.forename: Norio
authors.initials: N
authors.lastname: Saito
authors.forename: Taira
authors.initials: T
authors.lastname: Kinoshita
mesh_terms: D000328:Adult; D000368:Aged; D015179:Colorectal Neoplasms / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000473:pathology; D003131:Combined Modality Therapy; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008113:Liver Neoplasms / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000556:secondary / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D049268:Positron-Emission Tomography / Q000379:methods; D019275:Radiopharmaceuticals
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18