title: Dependence of nanodosimetric spectra on the sensitive volume length and ion drift in an ion-counting nanodosemeter.
abstract: Nanodosimetric spectra, measured in a well-defined ionisation sensitive volume of an ion-counting gaseous nanodosemeter, may have a valuable predictive value of radiation damage to DNA. In such devices, the distributions of radiation-induced ions are measured after their drift in gas. The sensitive-volume size, corresponding to a DNA segment length, can be tuned by selecting an appropriate time window for ion counting; the method's accuracy depends on the velocity distribution of the drifting ions. The results of ion-drift measurements in an ion-counting nanodosemeter were used for the precise calculation of its sensitive volume length. Monte Carlo simulations of nanodosimetric spectra, performed with the obtained data, are in good agreement with experimental data. The method's limitations, arising from the spread of drift velocities, are discussed.
authors.affiliation: Weizmann Institute of Science, 76100 Rehovot, Israel.
authors.forename: S
authors.initials: S
authors.lastname: Shchemelinin
authors.forename: G
authors.initials: G
authors.lastname: Hilgers
authors.forename: E
authors.initials: E
authors.lastname: Gargioni
authors.forename: B
authors.initials: B
authors.lastname: Grosswendt
authors.forename: A
authors.initials: A
authors.lastname: Breskin
authors.forename: R
authors.initials: R
authors.lastname: Chechik
mesh_terms: D016477:Artifacts; D003198:Computer Simulation; D017076:Computer-Aided Design; D004307:Dose-Response Relationship, Radiation; D004867:Equipment Design; D019544:Equipment Failure Analysis; D007477:Ions; D008904:Miniaturization; D008962:Models, Theoretical; D036103:Nanotechnology / Q000295:instrumentation* / Q000379:methods; D011829:Radiation Dosage; D011874:Radiometry / Q000295:instrumentation* / Q000379:methods; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013057:Spectrum Analysis / Q000295:instrumentation / Q000379:methods
chemical_list: D007477:Ions