Running to stand still: ionotropic receptor dynamics at central and peripheral synapses.
For synapses to form and function, neurotransmitter receptors must be recruited to a location on the postsynaptic cell in direct apposition to presynaptic neurotransmitter release. However, once receptors are inserted into the postsynaptic membrane, they are not fixed in place but are continually exchanged between synaptic and extrasynaptic regions, and they cycle between the surface and intracellular compartments. This article highlights and compares the current knowledge about the dynamics of acetylcholine receptors at the vertebrate peripheral neuromuscular junction and AMPA, N-methyl-D-aspartate, and gamma-aminobutyric acid receptors in central synapses.
Bruneau
Emile G
EG
Department of Molecular, Cellular and Developmental Biology and Program in Neuroscience, University of Michigan, Ann Arbor, MI, USA.
Akaaboune
Mohammed
M
D000818:Animals; D002490:Central Nervous System / Q000378:metabolism* / Q000648:ultrastructure; D006801:Humans; D009469:Neuromuscular Junction / Q000378:metabolism / Q000648:ultrastructure; D017933:Peripheral Nervous System / Q000378:metabolism* / Q000648:ultrastructure; D011940:Receptor Aggregation / Q000502:physiology; D018079:Receptors, GABA / Q000378:metabolism; D017470:Receptors, Glutamate / Q000378:metabolism; D017981:Receptors, Neurotransmitter / Q000378:metabolism*; D011978:Receptors, Nicotinic / Q000378:metabolism; D013570:Synaptic Membranes / Q000378:metabolism* / Q000648:ultrastructure; D009435:Synaptic Transmission / Q000502:physiology*
D018079:Receptors, GABA; D017470:Receptors, Glutamate; D017981:Receptors, Neurotransmitter; D011978:Receptors, Nicotinic