title: Elevated IgG titers to periodontal pathogens related to Buerger disease.
abstract: BACKGROUND
  Periodontal pathogens were frequently detected in the occluded arteries of Buerger disease patients, hence we hypothesized that the infection from periodontal pathogens may be associated with Buerger disease.
  
  
  METHODS
  We investigated periodontal status using various clinical parameters and serum IgG antibody levels against T. denticola, P. gingivalis, A. actinomycetemcomitans and P. intermedia in nineteen Buerger disease patients and fifteen control subjects. The results were statistically analyzed.
  
  
  RESULTS
  The prevalence of periodontitis and the percentages of probing sites with PD> or =4 mm and CAL> or =4 mm were significantly higher in the patient group (P<0.001, P=0.016, and P<0.001, respectively). Patients had significantly higher serum IgG titers against T. denticola, P. gingivalis and A. actinomycetemcomitans (P=0.002, P=0.039, and P=0.011, respectively).
  
  
  CONCLUSIONS
  This study provides evidence for possible implications of periodontitis in Buerger disease.
authors.forename: Yi-Wen
authors.initials: YW
authors.lastname: Chen
authors.forename: Takehisa
authors.initials: T
authors.lastname: Iwai
authors.forename: Makoto
authors.initials: M
authors.lastname: Umeda
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Nagasawa
authors.forename: Yi
authors.initials: Y
authors.lastname: Huang
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Takeuchi
authors.forename: Isao
authors.initials: I
authors.lastname: Ishikawa
mesh_terms: D016976:Aggregatibacter actinomycetemcomitans / Q000276:immunology; D016022:Case-Control Studies; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D010518:Periodontitis / Q000097:blood / Q000453:epidemiology / Q000382:microbiology*; D016966:Porphyromonas gingivalis / Q000276:immunology; D018713:Prevotella intermedia / Q000276:immunology; D013919:Thromboangiitis Obliterans / Q000097:blood* / Q000276:immunology / Q000382:microbiology; D048373:Treponema denticola / Q000276:immunology
chemical_list: D007074:Immunoglobulin G