[How estrogens will surprise us again?].
Estrogens are pleiotropic hormones having an influence not only on reproductive system and sexual functions. These hormones are synthesized not only by ovaries, but also by glia in central nervous system (CNS) and Schwann cells in peripheral nervous system. Therefore they create microenvironment having a wide spectrum of effects such as neuroprotective and antiapoptotic or supporting neurogenesis and regeneration. Mechanisms of estrogens activity are both genomic and quick non-genomic transmitted through second intracellular messengers. There is evidence for protective action of estrogens in neurodegenerative diseases and other diseases of CNS. Nevertheless there are still secrets in estrogens nature. This fact pushes us to ask more questions and continue scientific research to look for the answer.
Malinowska-Kołodziej
Izabela
I
Z Katedry i Zakładu Fizjologii Slaskiej Akademii Medycznej, Katowicach.
Marcol
Wiesław
W
Lewin-Kowalik
Joanna
J
D000544:Alzheimer Disease / Q000188:drug therapy / Q000517:prevention & control; D000818:Animals; D002490:Central Nervous System / Q000187:drug effects* / Q000502:physiology; D004958:Estradiol / Q000494:pharmacology / Q000502:physiology; D004967:Estrogens / Q000502:physiology*; D005260:Female; D005298:Fertility / Q000502:physiology*; D015971:Gene Expression Regulation, Enzymologic / Q000187:drug effects; D006801:Humans; D008297:Male; D019964:Mood Disorders / Q000188:drug therapy / Q000517:prevention & control; D019636:Neurodegenerative Diseases / Q000188:drug therapy / Q000378:metabolism / Q000517:prevention & control; D009474:Neurons / Q000502:physiology; D018696:Neuroprotective Agents / Q000494:pharmacology; D048789:Phytoestrogens / Q000494:pharmacology*; D051381:Rats; D011960:Receptors, Estrogen / Q000187:drug effects*
D004967:Estrogens; D018696:Neuroprotective Agents; D048789:Phytoestrogens; D011960:Receptors, Estrogen; D004958:Estradiol