title: HeLa cells apoptosis induced by 1,7-dimethyl-1,4,7,10-tetraazacyclododecane.
abstract: Preliminary pharmacological tests showed that 1,7-dimethyl-1,4,7,10-tetraazacyclododecane (DMC) had antitumor activity against HeLa and A549 cell lines in vitro. The HeLa cells apoptosis induced by DMC was examined by flow cytometric meter, and further confirmed by observing the morphological changes and DNA fragmentation. No observation of A549 cells induced apoptosis was observed by DMC.
authors.affiliation: College of Chemistry and Molecular Sciences, Wuhan University, Hubei, Wuhan 430072, PR China. chemoliangf@yahoo.com.cn
authors.forename: Li
authors.initials: L
authors.lastname: Yang
authors.forename: Feng
authors.initials: F
authors.lastname: Liang
authors.forename: Min
authors.initials: M
authors.lastname: Liu
authors.forename: Congyi
authors.initials: C
authors.lastname: Zheng
authors.forename: Shuhui
authors.initials: S
authors.lastname: Wan
authors.forename: Xiaoqin
authors.initials: X
authors.lastname: Xiong
authors.forename: Xiaolian
authors.initials: X
authors.lastname: Zhang
authors.forename: Chao
authors.initials: C
authors.lastname: Shen
authors.forename: Xiang
authors.initials: X
authors.lastname: Zhou
mesh_terms: D017209:Apoptosis / Q000187:drug effects*; D002453:Cell Cycle / Q000187:drug effects; D045744:Cell Line, Tumor; D053938:DNA Fragmentation / Q000187:drug effects; D004273:DNA, Neoplasm / Q000187:drug effects; D005434:Flow Cytometry; D006367:HeLa Cells; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*; D006801:Humans
chemical_list: C512308:1,7-dimethyl-1,4,7,10-tetraazacyclododecane; D004273:DNA, Neoplasm; D006571:Heterocyclic Compounds