title: Novel sulfamide analogs of oleoylethanolamide showing in vivo satiety inducing actions and PPARalpha activation.
abstract: Long chain saturated and unsaturated alkyl sulfamide and propyl sulfamide derivatives, analogs of oleoylethanolamide, have been synthesized and evaluated in vivo and in vitro as peroxisome proliferator activated receptor alpha (PPARalpha) activators. Additionally, the anorexic effects of the new compounds have been studied in vivo in food-deprived rats. Among the active compounds N-octadecyl-N'-propylsulfamide (7) has been identified as a potent hypolipidemic compound, a potent feeding suppressant, and a concentration-dependent activator of PPARalpha.
authors.affiliation: Instituto de Química Médica, CSIC, Juan de la Cierva 3, 28006, Madrid, Spain.
authors.forename: Carolina
authors.initials: C
authors.lastname: Cano
authors.forename: Javier
authors.initials: J
authors.lastname: Pavón
authors.forename: Antonia
authors.initials: A
authors.lastname: Serrano
authors.forename: Pilar
authors.initials: P
authors.lastname: Goya
authors.forename: Juan Antonio
authors.initials: JA
authors.lastname: Paez
authors.forename: Fernando Rodriguez
authors.initials: FR
authors.lastname: de Fonseca
authors.forename: Manuel
authors.initials: M
authors.lastname: Macias-Gonzalez
mesh_terms: D000818:Animals; D001067:Appetite Depressants / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D003065:Coenzyme A / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004435:Eating / Q000187:drug effects; D063388:Endocannabinoids; D005508:Food Deprivation; D017930:Genes, Reporter; D006801:Humans; D000960:Hypolipidemic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D008156:Luciferases / Q000096:biosynthesis / Q000235:genetics; D009829:Oleic Acids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D047493:PPAR alpha / Q000819:agonists* / Q000235:genetics / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D011924:Rats, Zucker; D012527:Satiation / Q000187:drug effects*; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D015533:Transcriptional Activation; D014162:Transfection
chemical_list: D001067:Appetite Depressants; D063388:Endocannabinoids; D000960:Hypolipidemic Agents; C517808:N-octadecyl-N'-propylsulfamide; D009829:Oleic Acids; D047493:PPAR alpha; D013449:Sulfonamides; C488250:oleoylethanolamide; D008156:Luciferases; D003065:Coenzyme A