Noninvasive diffuse optical measurement of blood flow and blood oxygenation for monitoring radiation therapy in patients with head and neck tumors: a pilot study.
This pilot study explores the potential of noninvasive diffuse correlation spectroscopy (DCS) and diffuse reflectance spectroscopy (DRS) for monitoring early relative blood flow (rBF), tissue oxygen saturation (StO(2)), and total hemoglobin concentration (THC) responses to chemo-radiation therapy in patients with head and neck tumors. rBF, StO(2), and THC in superficial neck tumor nodes of eight patients are measured before and during the chemo-radiation therapy period. The weekly rBF, StO(2), and THC kinetics exhibit different patterns for different individuals, including significant early blood flow changes during the first two weeks. Averaged blood flow increases (52.7+/-9.7)% in the first week and decreases (42.4+/-7.0)% in the second week. Averaged StO(2) increases from (62.9+/-3.4)% baseline value to (70.4+/-3.2)% at the end of the second week, and averaged THC exhibits a continuous decrease from pretreatment value of (80.7+/-7.0) [microM] to (73.3+/-8.3) [microM] at the end of the second week and to (63.0+/-8.1) [microM] at the end of the fourth week of therapy. These preliminary results suggest daily diffuse-optics-based therapy monitoring is feasible during the first two weeks and may have clinical promise.
Sunar
Ulas
U
Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6396, USA. sunar@sas.upenn.edu
Quon
Harry
H
Durduran
Turgut
T
Zhang
Jun
J
Du
Juan
J
Zhou
Chao
C
Yu
Guoqiang
G
Choe
Regine
R
Kilger
Alex
A
Lustig
Robert
R
Loevner
Laurie
L
Nioka
Shoko
S
Chance
Britton
B
Yodh
Arjun G
AG
D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood; D001783:Blood Flow Velocity; D005240:Feasibility Studies; D005260:Female; D006258:Head and Neck Neoplasms / Q000097:blood / Q000098:blood supply / Q000175:diagnosis* / Q000532:radiotherapy*; D006454:Hemoglobins / Q000032:analysis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood*; D010865:Pilot Projects; D011379:Prognosis; D011881:Radiotherapy, Computer-Assisted / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013057:Spectrum Analysis / Q000379:methods*; D016896:Treatment Outcome
D014408:Biomarkers, Tumor; D006454:Hemoglobins; D010100:Oxygen