Hit 'em where they live: targeting the cancer stem cell niche.
Cancer stem cells (CSCs) are thought to be critical for initiation and propagation of many types of cancer. Because these cells are resistant to conventional therapies, they have been very difficult to eliminate. A study in this issue of Cancer Cell suggests that brain tumor CSCs live in a "vascular niche" that promotes their long-term growth and self-renewal. Disrupting this niche impairs CSC self-renewal and thereby significantly inhibits the growth of tumors. Targeting the unique microenvironment of CSCs may be the key to effective cancer therapy.
Yang
Zeng-Jie
ZJ
Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA.
Wechsler-Reya
Robert J
RJ
D000818:Animals; D001932:Brain Neoplasms / Q000098:blood supply* / Q000473:pathology; D006801:Humans; D014411:Neoplastic Stem Cells; D009389:Neovascularization, Pathologic; D009474:Neurons / Q000473:pathology