title: Predicting coma and other low responsive patients outcome using event-related brain potentials: a meta-analysis.
abstract: OBJECTIVE
  A meta-analysis was performed to estimate the predictive power (odd ratio, OR) for awakening of auditory event-related potential (ERP) components in low responsive patients with stroke or hemorrhage, trauma, anoxic, post-operative, and metabolic encephalopathy etiologies.
  
  
  METHODS
  We reviewed MEDLINE and analyzed citations for retrieved articles. Logistic regressions were applied on patient samples (Glasgow Coma Scale <12) across and for separate etiologies.
  
  
  RESULTS
  For stroke and hemorrhage the ORs with 95% confidence intervals were: 2.05 [1.12-3.75] (N100), 4.47 [1.92-10.44] (MMN), 10.29 [2.00-52.79] (P300), for trauma: 1.63 [0.70-3.80] (N100), 4.72 [1.35-16.44] (MMN), 12.89 [4.82-34.43] (P300), anoxic: 8.03 [2.83-22.75] (N100), 15.50 [4.27-56.26] (MMN), 5.93 [2.38-14.77] (P300), post-operative: 10.66 [1.98-57.50] (N100), metabolic encephalopathy: 2.12 [0.34-13.13] (N100), 3.60 [0.28-46.36] (MMN), 7.71 [0.75-79.77] (P300), and all etiologies: 2.85 [1.91-4.27] (N100), 6.53 [3.55-12.01] (MMN), and 8.79 [4.88-15.83] (P300). Based on six N100 studies (N=548 patients), five MMN studies (N=470), and six P300 studies (N=313), the N100, MMN, or P300, when present, significantly predicted awakening, P300 and MMN being significantly better predictors than N100.
  
  
  CONCLUSIONS
  The MMN and P300 appear to be reliable predictors of awakening.
  
  
  CONCLUSIONS
  The prognostic assessment of low responsive patients with auditory ERP should take into account both MMN and P300.
authors.affiliation: Department of Neurology, University Hospital of Strasbourg, France. jerome.daltrozzo@chru-strasbourg.fr
authors.forename: J
authors.initials: J
authors.lastname: Daltrozzo
authors.forename: N
authors.initials: N
authors.lastname: Wioland
authors.forename: V
authors.initials: V
authors.lastname: Mutschler
authors.forename: B
authors.initials: B
authors.lastname: Kotchoubey
mesh_terms: D003128:Coma / Q000175:diagnosis / Q000503:physiopathology*; D003243:Consciousness / Q000502:physiology; D003265:Contingent Negative Variation / Q000502:physiology; D004569:Electroencephalography; D018913:Event-Related Potentials, P300 / Q000502:physiology; D005071:Evoked Potentials / Q000502:physiology*; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D015600:Glasgow Coma Scale; D006801:Humans; D016015:Logistic Models; D016017:Odds Ratio; D018458:Persistent Vegetative State / Q000175:diagnosis / Q000503:physiopathology*; D011237:Predictive Value of Tests; D011379:Prognosis