Platinum(II)-catalyzed cyclizations forming quaternary carbon centers, using enesulfonamides, enecarbamates, or enamides as nucleophiles.
Cyclic enesulfonamides, enecarbamates, or enamides tethered to an alkyne cyclize readily with use of platinum(II) chloride. This reaction generates quaternary-substituted carbon centers within simple spiro-fused or more complex tri- and tetracyclic heterocyclic ring systems. The yields for this process range from 50% to 83%. [reaction: see text].
Harrison
Tyler J
TJ
Department of Chemistry, 2036 Main Mall, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z1.
Patrick
Brian O
BO
Dake
Gregory R
GR
D000475:Alkenes / Q000138:chemical synthesis* / Q000737:chemistry; D000480:Alkynes / Q000737:chemistry*; D000577:Amides / Q000737:chemistry*; D002219:Carbamates / Q000737:chemistry*; D002244:Carbon / Q000737:chemistry; D002384:Catalysis; D003500:Cyclization; D015394:Molecular Structure; D017671:Platinum Compounds / Q000737:chemistry*; D013237:Stereoisomerism
D000475:Alkenes; D000480:Alkynes; D000577:Amides; D002219:Carbamates; D017671:Platinum Compounds; C030173:platinum chloride; D002244:Carbon