title: Development of a pharmaceutical cocrystal of a monophosphate salt with phosphoric acid.
abstract: We report the first case of a pharmaceutical cocrystal formed between an inorganic acid and an active pharmaceutical ingredient (API), which enabled us to develop a stable crystalline and bioavailable solid dosage form for pharmaceutical development where otherwise only unstable amorphous free form or salts could have been used.
authors.affiliation: Merck & Co. Inc., PO Box 2000, Rahway, New Jersey 07065, USA. alex_chen2@merck.com
authors.forename: Alex M
authors.initials: AM
authors.lastname: Chen
authors.forename: Martha E
authors.initials: ME
authors.lastname: Ellison
authors.forename: Andrey
authors.initials: A
authors.lastname: Peresypkin
authors.forename: Robert M
authors.initials: RM
authors.lastname: Wenslow
authors.forename: Narayan
authors.initials: N
authors.lastname: Variankaval
authors.forename: Cecile G
authors.initials: CG
authors.lastname: Savarin
authors.forename: Theresa K
authors.initials: TK
authors.lastname: Natishan
authors.forename: David J
authors.initials: DJ
authors.lastname: Mathre
authors.forename: Peter G
authors.initials: PG
authors.lastname: Dormer
authors.forename: Danielle H
authors.initials: DH
authors.lastname: Euler
authors.forename: Richard G
authors.initials: RG
authors.lastname: Ball
authors.forename: Zhixiong
authors.initials: Z
authors.lastname: Ye
authors.forename: Yaling
authors.initials: Y
authors.lastname: Wang
authors.forename: Ivan
authors.initials: I
authors.lastname: Santos
mesh_terms: D003460:Crystallization; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D015394:Molecular Structure; D010710:Phosphates / Q000737:chemistry* / Q000494:pharmacology; D010756:Phosphoric Acids / Q000737:chemistry*
chemical_list: D010710:Phosphates; D010756:Phosphoric Acids; C030242:phosphoric acid