Adrenal function in 23 children with paracoccidioidomycosis.
Adrenal involvement by Paracoccidioides brasiliensis was described at necropsies and in many clinical studies, but only in adults. Therefore, the aim of this study was to evaluate adrenal function in children with paracoccidioidomycosis. Twenty-three children with the systemic form of paracoccidioidomycosis were evaluated and divided in two Groups: Group A (n = 8) included children before treatment and Group B (n = 15) children after the end of treatment. Plasma cortisol (basal and after ACTH test), ACTH, renin activity, aldosterone, sodium and potassium were measured. They were within normal range in all cases, except for renin activity and aldosterone, which were elevated in some cases. Group A patients showed basal and post-ACTH cortisol levels significantly greater than Group B patients. The results showed that adrenal function was not compromised in these children with paracoccidioidomycosis.
Pereira
Ricardo Mendes
RM
Departamento de Pediatria, Faculdade de Ciências Médicas, Universidade Estadual de Campinas, Rua Dr. Shigeo Mori 860, 13084-081 Campinas, São Paulo, Brazil. ricardom.p@uol.com.br
Guerra-Júnior
Gil
G
Tresoldi
Antonia Terezinha
AT
D015062:11-Hydroxycorticosteroids / Q000097:blood*; D000302:Adrenal Cortex / Q000378:metabolism / Q000503:physiopathology*; D000324:Adrenocorticotropic Hormone / Q000097:blood*; D002648:Child; D006801:Humans; D010229:Paracoccidioidomycosis / Q000097:blood / Q000503:physiopathology*; D011188:Potassium / Q000097:blood; D012083:Renin / Q000097:blood*; D012964:Sodium / Q000097:blood
D015062:11-Hydroxycorticosteroids; D000324:Adrenocorticotropic Hormone; D012964:Sodium; D012083:Renin; D011188:Potassium