[BCG vaccination and development of an innovative vaccine for preventing vertical HIV transmission in Africa].
"Families First Africa" is an international project whose main objective is to develop a pediatric vaccine that protects infants against HIV transmission during breast feeding. The vaccine being developed consists of HIV peptides matching HLA genotypes of the Western Africa population and will be administered in association with BCG vaccine which acts as a strong adjuvant. An alternative strategy is to administer a recombinant BCG vaccine with HIV gene fragments which codify for the same peptides.
Pontrelli
Giuseppe
G
Scuola di Specializzazione in Igiene e Medicina Preventiva, Università Tor Vergata, Roma.
Colizzi
Vittorio
V
D016915:AIDS Vaccines / Q000008:administration & dosage / Q000235:genetics / Q000276:immunology; D000276:Adjuvants, Immunologic / Q000008:administration & dosage*; D000328:Adult; D000349:Africa; D000818:Animals; D001500:BCG Vaccine / Q000008:administration & dosage*; D001942:Breast Feeding; D017321:Clinical Trials, Phase I as Topic; D017322:Clinical Trials, Phase II as Topic; D004195:Disease Models, Animal; D000939:Epitopes; D005260:Female; D005544:Forecasting; D015658:HIV Infections / Q000517:prevention & control* / Q000635:transmission*; D015497:HIV-1 / Q000235:genetics / Q000276:immunology; D006801:Humans; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical; D007391:International Cooperation; D035703:Therapies, Investigational
D016915:AIDS Vaccines; D000276:Adjuvants, Immunologic; D001500:BCG Vaccine; D000939:Epitopes