title: [Prevention of brain infarction in patients with atrial fibrillation].
abstract: The patients with cardioembolic stroke sometimes suffer from severe neurological deficit and from recurrent strokes. Since atrial fibrillation, especially non-valvular atrial fibrillation (NVAF) is associated with over half of the cardioembolic strokes, the prevention of cardioembolic stroke in patients with NVAF is important. There have been some reports about how to prevent stroke. They have indicated that the best medication for preventing from stroke was anticoagulation by warfarin. Therefore, the guidelines recommended the patients with NVAF to take warfarin. In case with the older patients under 70 years, prothrombin international normalized ratio (PT-INR) should be kept from 2.0 to 3.0. On the other hand, if the patients with NVAF are over 70 years, PT-INR has to be controlled from 1.6 to 2.6. Before extraction of a tooth, anticoagulation should not be call off.
authors.affiliation: Department of Cerebrovascular Disease, Cerebrovascular Center and Clinical Research Institute, National Hospital Organization Kyushu Medical Center, 1-8-1 Jigyohama, Chuo-ku, Fukuoka 810-0065, Japan.
authors.forename: Toshiyasu
authors.initials: T
authors.lastname: Ogata
authors.forename: Masahiro
authors.initials: M
authors.lastname: Yasaka
mesh_terms: D000367:Age Factors; D000925:Anticoagulants / Q000008:administration & dosage*; D001281:Atrial Fibrillation / Q000150:complications* / Q000453:epidemiology / Q000628:therapy; D002544:Cerebral Infarction / Q000453:epidemiology / Q000209:etiology* / Q000517:prevention & control*; D002986:Clinical Trials as Topic; D006339:Heart Rate; D006801:Humans; D015201:Meta-Analysis as Topic; D010353:Patient Education as Topic; D017410:Practice Guidelines as Topic; D014081:Tooth Extraction; D014859:Warfarin / Q000008:administration & dosage*
chemical_list: D000925:Anticoagulants; D014859:Warfarin