Reactive oxygen metabolites: a link between oxidative stress and inflammation in patients on hemodialysis.
Oxidative stress plays a significant role in the development of inflammation in patients undergoing hemodialysis (HD). This study intends to evaluate the relationship between C-reactive protein (CRP) and the newly established marker of lipid peroxidation, d-ROMs (reactive oxygen metabolites), in comparison with different indicators of oxidative stress. Plasma total antioxidant capacity (TAC), lipid peroxidation products malonaldehyde (MDA) and 4-hydroxyalkenals, as well as d-ROMs, were determined in 24 patients before HD and in 21 normal controls (NC). It was found that HD patients had higher levels of d-ROMs than NC (p = 0.033). A highly significant positive correlation was observed between logCRP and d-ROMs concentrations (p < 0.0001, r = 0.85) in patients, but not in NC. The concentrations of TAC and MDA were not associated with CRP in HD or in NC individuals. It is concluded that d-ROMs concentration is a potent marker of oxidative injury that is strongly indicative of the inflammatory status in HD patients.
Samouilidou
E
E
Biochemical Department, Alexandra Hospital, Athens, Greece. tkk@otenet.gr
Grapsa
E
E
Karpouza
A
A
Lagouranis
A
A
D000328:Adult; D000447:Aldehydes / Q000097:blood; D000975:Antioxidants / Q000378:metabolism; D002097:C-Reactive Protein / Q000378:metabolism; D005260:Female; D006801:Humans; D007249:Inflammation / Q000209:etiology*; D008054:Lipid Peroxides / Q000097:blood; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology*; D017382:Reactive Oxygen Species / Q000378:metabolism*; D006435:Renal Dialysis / Q000009:adverse effects*
D000447:Aldehydes; D000975:Antioxidants; D008054:Lipid Peroxides; D017382:Reactive Oxygen Species; D008315:Malondialdehyde; D002097:C-Reactive Protein