title: Sarcomatoid eccrine porocarcinoma: report of two cases and a review of the literature.
abstract: Eccrine porocarcinoma is an uncommon sweat gland malignancy. To the best of our knowledge, there has been no report in the English literature of porocarcinoma with predominantly undifferentiated sarcomatous change. We present two cases of sarcomatoid eccrine porocarcinoma associated with a benign poroma. Case 1 pertained to an 82-year-old woman with an ulcerated chest wall tumor, and Case 2 was that of a 74-year-old woman who presented with an ulcerated plaque in the lower leg. Case 1 showed an unusual pseudo-angiosarcomatous morphology with spindle cells dissecting through collagen bundles and forming vascular like channels. Case 2 revealed high-grade malignant spindle cells with focal evidence of ductal differentiation. In both the cases, benign poromatous elements were histologically evident. Immunohistochemistry performed showed pancytokeratin positivity in spindle cells of both lesions. Epithelial membrane antigen and carcino-embryonic antigen positivity in the malignant ductal elements and focal smooth muscle actin staining of the spindle cells were demonstrated in Case 2. A brief review of relevant literature is presented.
authors.affiliation: St John's Institute of Dermatology, St Thomas' Hospital, London, UK.
authors.forename: Seng Geok Nicholas
authors.initials: SG
authors.lastname: Goh
authors.forename: Johannes F
authors.initials: JF
authors.lastname: Dayrit
authors.forename: Eduardo
authors.initials: E
authors.lastname: Calonje
mesh_terms: D018250:Acrospiroma / Q000378:metabolism / Q000473:pathology*; D000199:Actins / Q000378:metabolism; D000368:Aged; D000369:Aged, 80 and over; D002272:Carcinoembryonic Antigen / Q000378:metabolism; D005260:Female; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D007633:Keratins / Q000378:metabolism; D007866:Leg; D018396:Mucin-1 / Q000378:metabolism; D009130:Muscle, Smooth / Q000378:metabolism; D012509:Sarcoma / Q000473:pathology; D013194:Staining and Labeling; D013544:Sweat Gland Neoplasms / Q000378:metabolism / Q000473:pathology*; D035441:Thoracic Wall
chemical_list: D000199:Actins; D002272:Carcinoembryonic Antigen; D018396:Mucin-1; D007633:Keratins