title: [Biomechanics of intracranial aneurysms].
abstract: BACKGROUND
  Viscoelastic parameters of circumferential and meridional strips of ruptured and silent aneurysms were investigated (considered clinical and histological data either) in order to advance the prediction of risk of aneurysm rupture.
  
  
  METHODS
  In our clinical practice, aneurysms managed by microsurgery aneurysm clipping were removed. Meridional and circumferential strips were cut. Strips were investigated by an uniaxial biomechanical instrument: distending force was recorded as the length of the strips was increased in steps. Normal stress-relaxation patterns were detected. The shape of strain curves well overlapped with the Standard Linear Solid Model curve, as had been expected. The viscosity, serial and parallel elastic moduli of the model were then computed.
  
  
  RESULTS
  Linear correlation was demonstrated amongst peek distending force detected and aneurysm strip thickness. Steric inhomogeneity was detected at the meridional and circumferential strips. Strain-stress behaviour of ruptured and silent aneurysm specimen showed significant difference. Values of strips originated from patients suffered from hypertension as well as strips originated from aneurysms had been histologically found inflamed were higher.
  
  
  CONCLUSIONS
  Results of these observations are going to be used to set three dimensional computer model in cooperation with IT team of Budapest University of Technology and Economics to advance rupture risk prediction.
authors.affiliation: Országos Idegsebészeti Tudományos Intézet, Budapest. ifarkas@oiti.hu
authors.forename: István
authors.initials: I
authors.lastname: Farkas
authors.forename: István
authors.initials: I
authors.lastname: Nyáry
authors.forename: Gábor
authors.initials: G
authors.lastname: Raffai
authors.forename: Gábor
authors.initials: G
authors.lastname: Zilahy
authors.forename: Emil
authors.initials: E
authors.lastname: Monos
mesh_terms: D017542:Aneurysm, Ruptured / Q000473:pathology / Q000503:physiopathology* / Q000601:surgery; D001696:Biomechanical Phenomena; D006801:Humans; D002532:Intracranial Aneurysm / Q000473:pathology / Q000503:physiopathology* / Q000601:surgery; D016014:Linear Models