title: [N-acetyl-L-cysteine as a therapeutic option in bacterial meningitis].
abstract: Despite antibiotic therapy, supportive intensive care, and adjunctive treatment with dexamethasone, the mortality and morbidity remain high in patients with bacterial meningitis. The intracranial complications that mainly contribute to the poor outcome are in part a result of the production of reactive oxygen and nitrogen species. Experimental studies have shown that the prognosis for bacterial meningitis can be improved by the administration of antioxidants. Especially adjunctive therapy with N-acetyl-L-cystein (NAC) was shown to have mainly positive effects. Since NAC is already in clinical use in high doses for treating other diseases (e.g., acetaminophen intoxication) and only minor side effects have been observed, there is justified hope that adjunctive therapy with NAC could improve the prognosis of patients with bacterial meningitis.
authors.affiliation: Neurologische Klinik und Poliklinik, Klinikum Grosshadern, LMU München.
authors.forename: M
authors.initials: M
authors.lastname: Klein
authors.forename: U
authors.initials: U
authors.lastname: Koedel
authors.forename: H W
authors.initials: HW
authors.lastname: Pfister
mesh_terms: D000111:Acetylcysteine / Q000627:therapeutic use*; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D017024:Chemotherapy, Adjuvant; D016166:Free Radical Scavengers / Q000627:therapeutic use*; D006801:Humans; D016920:Meningitis, Bacterial / Q000188:drug therapy* / Q000517:prevention & control*; D017410:Practice Guidelines as Topic; D010818:Practice Patterns, Physicians'; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D016166:Free Radical Scavengers; D000111:Acetylcysteine