Phenylpropanolamine contained in cold remedies and risk of hemorrhagic stroke.
In this study, we sought to elucidate whether phenylpropanolamine (PPA) in cold remedies (small and divided doses) increases the risk of hemorrhagic stroke (HS). PPA exposure significantly increased the risk, and the risk was much higher in women. In women, linear trends were also found in recency, duration, and dosage of PPA exposure. PPA contained in cold remedies increases the risk of HS, particularly in women.
Yoon
B W
BW
Department of Neurology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, 110-744, Republic of Korea. bwyoon@snu.ac.kr
Bae
H J
HJ
Hong
K S
KS
Lee
S M
SM
Park
B J
BJ
Yu
K H
KH
Han
M K
MK
Lee
Y S
YS
Chung
D K
DK
Park
J M
JM
Jeong
S W
SW
Lee
B C
BC
Cho
K H
KH
Kim
J S
JS
Lee
S H
SH
Yoo
K M
KM
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D003139:Common Cold / Q000188:drug therapy / Q000453:epidemiology; D015897:Comorbidity; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D015994:Incidence; D020300:Intracranial Hemorrhages / Q000453:epidemiology*; D007723:Korea / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D014663:Nasal Decongestants / Q000627:therapeutic use; D004366:Nonprescription Drugs / Q000627:therapeutic use; D010665:Phenylpropanolamine / Q000627:therapeutic use*; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D020521:Stroke / Q000453:epidemiology*
D014663:Nasal Decongestants; D004366:Nonprescription Drugs; D010665:Phenylpropanolamine