title: The circling mouse (C57BL/6J-cir) has a 40-kilobase genomic deletion that includes the transmembrane inner ear (tmie) gene.
abstract: The circling mouse (C57BL6-cir) shows deafness and circling behavior in homozygotes. The mutation is transmitted with 100% penetrance by an autosomal recessive gene on chromosome 9. In the present study, we characterized the circling mutation as a 40-kilobase deletion that includes the transmembrane inner ear (tmie) gene. The tmie gene was first identified because its mutation causes deafness and circling behavior in spinner mice. We suggest that the genomic deletion of circling mice is a different, but allelic, mutation to that of spinner mice. In addition, during general behavioral investigations for complementation tests of the 2 strains, we found that circling and spinner mice may differ in their behavioral responses to a new environment.
authors.affiliation: Department of Medical Genetics and Experimental Animal Center, College of Medicine, Hallym University, Chunchon 200-702, South Korea. jaewoong64@hanmail.net
authors.forename: Kyoung In
authors.initials: KI
authors.lastname: Cho
authors.forename: Jun-Gyo
authors.initials: JG
authors.lastname: Suh
authors.forename: Jeong Woong
authors.initials: JW
authors.lastname: Lee
authors.forename: Sung Hwa
authors.initials: SH
authors.lastname: Hong
authors.forename: Tae-Cheon
authors.initials: TC
authors.lastname: Kang
authors.forename: Yang-Seok
authors.initials: YS
authors.lastname: Oh
authors.forename: Zae Young
authors.initials: ZY
authors.lastname: Ryoo
mesh_terms: D000483:Alleles; D000818:Animals; D001483:Base Sequence; D001522:Behavior, Animal; D001947:Breeding; D017931:DNA Primers / Q000235:genetics; D003638:Deafness / Q000235:genetics*; D004195:Disease Models, Animal; D005260:Female; D017353:Gene Deletion; D005808:Genes, Recessive; D005816:Genetic Complementation Test; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D051379:Mice; D008810:Mice, Inbred C57BL; D008817:Mice, Mutant Strains; D009154:Mutation
chemical_list: D017931:DNA Primers; D008565:Membrane Proteins