[Clinical observation on treatment of somatic disorder with combination of Xiaoyao Powder and Wendan Decoction].
OBJECTIVE
To compare the efficacy of Chinese medicine and selective serotonin reuptake inhibitors (SSRI), fluoxetine, on somatic disorder (SD) and to explore the advantage of Chinese medicine.


METHODS
Patients with SD screened with Hamilton depression scale (HAMD) were randomly assigned to the fluoxetine group treated with fluoxetine 20 mg once per day administered after breakfast, and the Chinese medicine group with combination of Xiaoyao Decoction (XD) and Wendan Decoction (WD) one dose a day given before supper everyday, the treatment for both groups was lasted for 8 weeks. Clinical general impression (CGI) and symptom checklist 90 (SCL-90) were applied to evaluate the changes in symptoms before and after treatment, and a self-made rating scale was used to evaluate the adverse reaction.


RESULTS
CGI score changed significantly in both groups after treatment, showed the average 2-week reduction rate of more than 30% and the average 8-week reduction rate of more than 70%, without significant difference shown between the two groups (P > 0.05). SCL-90 scoring showed the average score of somatic factor was significantly lower in the Chinese medicine group than in the fluoxetine group (P < 0.05) with few adverse reaction, while no significant difference was found in the respective scores of other factors between the two groups (P > 0.05).


CONCLUSIONS
Chinese medicine shows noticeable superiority in treating SD, it has the effect similar to that of new antidepressants.
Yu
Hai-Ting
HT
The Eighth People's Hospital of Zhengzhou City, Zhengzhou. yht55686@sina.com
D000328:Adult; D004359:Drug Therapy, Combination; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy; D013001:Somatoform Disorders / Q000188:drug therapy* / Q000523:psychology; D016896:Treatment Outcome
D004365:Drugs, Chinese Herbal; C528423:wendan; C516449:xiaoyao