Biomolecule-nanoparticle hybrids as functional units for nanobiotechnology.
Biomolecule-metal or semiconductor nanoparticle (NP) hybrid systems combine the recognition and catalytic properties of biomolecules with the unique electronic and optical properties of NPs. This enables the application of the hybrid systems in developing new electronic and optical biosensors, to synthesize nanowires and nanocircuits, and to fabricate new devices. Metal NPs are employed as nano-connectors that activate redox enzymes, and they act as electrical or optical labels for biorecognition events. Similarly, semiconductor NPs act as optical probes for biorecognition processes. Double-stranded DNA or protein chains that are modified with metallic nanoclusters act as templates for the synthesis of metallic nanowires. The nanowires are used as building blocks to assemble nano-devices such as a transistor or a nanotransporter.
Baron
Ronan
R
Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem, 91904, Israel.
Willner
Bilha
B
Willner
Itamar
I
D001709:Biotechnology; D002384:Catalysis; D004247:DNA / Q000737:chemistry / Q000378:metabolism; D004566:Electrodes; D006046:Gold / Q000737:chemistry; D008855:Microscopy, Electron, Scanning; D015394:Molecular Structure; D014442:Monophenol Monooxygenase / Q000378:metabolism; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D036103:Nanotechnology; D053770:Nanowires / Q000737:chemistry; D016615:Telomere / Q000737:chemistry / Q000378:metabolism; D014443:Tyrosine / Q000378:metabolism
D014443:Tyrosine; D006046:Gold; D004247:DNA; D014442:Monophenol Monooxygenase