title: In vitro studies with DQ-113 and comparison fluoroquinolones to determine propensities to select resistance in gram-positive cocci.
abstract: DQ-113 was compared in vitro to sitafloxacin, moxifloxacin, levofloxacin, and ciprofloxacin for potential to select mutational resistance in multiresistant staphylococci, pneumococci, and enterococci. Its ability to select less-susceptible mutants varied according to species, being lowest with staphylococci, intermediate with pneumococci, and greatest with enterococci.
authors.affiliation: Creighton University School of Medicine, Department of Medical Microbiology and Immunology, Center for Research in Anti-Infectives and Biotechnology, 2500 California Plaza, Omaha, NE 68178, USA.
authors.forename: Seong Geun
authors.initials: SG
authors.lastname: Hong
authors.forename: Ellen Smith
authors.initials: ES
authors.lastname: Moland
authors.forename: Paul A
authors.initials: PA
authors.lastname: Wickman
authors.forename: Jennifer A
authors.initials: JA
authors.lastname: Black
authors.forename: Ashfaque
authors.initials: A
authors.lastname: Hossain
authors.forename: Nancy D
authors.initials: ND
authors.lastname: Hanson
authors.forename: Kenneth S
authors.initials: KS
authors.lastname: Thomson
mesh_terms: D024881:Drug Resistance, Bacterial; D004352:Drug Resistance, Microbial / Q000235:genetics; D024841:Fluoroquinolones / Q000494:pharmacology*; D016908:Gram-Positive Bacterial Infections / Q000382:microbiology; D006095:Gram-Positive Cocci / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D008826:Microbial Sensitivity Tests; D015363:Quinolones / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: C456082:DQ113; D024841:Fluoroquinolones; D015363:Quinolones