title: Prostate cancer detection in men with an initial diagnosis of atypical small acinar proliferation.
abstract: OBJECTIVE
  To determine the subsequent prostatic adenocarcinoma detection rate amongst men with an initial diagnosis of atypical small acinar proliferation (ASAP).
  
  
  METHODS
  We reviewed the Illawarra Prostate Pathology Database over a 10-year period (January 1994 to January 2004) for specimens diagnosed as ASAP. These specimens were re-reviewed and clinical data obtained.
  
  
  RESULTS
  Of 61 cases of ASAP, there were complete follow-up data for 31. In this group nine patients had no further biopsies at our institution; the other 22 had at least one repeat biopsy. The incidence of prostatic adenocarcinoma in this group was 17/31 (55%). This included 13 diagnoses on second biopsy, three on third biopsy and one diagnosed at another institution.
  
  
  CONCLUSIONS
  This study showed a detection rate for prostatic adenocarcinoma of 55% after an initial diagnosis of ASAP, which indicates that an initial diagnosis of ASAP mandates re-biopsy.
authors.affiliation: Department of Urology, The Wollongong Hospital, Sydney, NSW, Australia. pascalmancuso@hotmail.com
authors.forename: Pascal A
authors.initials: PA
authors.lastname: Mancuso
authors.forename: Charles
authors.initials: C
authors.lastname: Chabert
authors.forename: Peter
authors.initials: P
authors.lastname: Chin
authors.forename: Paul
authors.initials: P
authors.lastname: Kovac
authors.forename: Timothy
authors.initials: T
authors.lastname: Skyring
authors.forename: William H
authors.initials: WH
authors.lastname: Watt
authors.forename: Sabar
authors.initials: S
authors.lastname: Napaki
mesh_terms: D000368:Aged; D001707:Biopsy, Needle; D018267:Carcinoma, Acinar Cell / Q000473:pathology*; D049109:Cell Proliferation; D015331:Cohort Studies; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D017430:Prostate-Specific Antigen / Q000097:blood; D019048:Prostatic Intraepithelial Neoplasia / Q000473:pathology*; D011471:Prostatic Neoplasms / Q000473:pathology*; D012189:Retrospective Studies
chemical_list: D017430:Prostate-Specific Antigen