Ten-year survival and risk of relapse for testicular cancer: a EUROCARE high resolution study.
Effective treatments for testicular cancer have been available since the 1970s, yet EUROCARE uncovered marked inter-country survival differences for this disease. To investigate these differences, we reviewed clinical records of 1350 testicular cancer cases diagnosed during 1987-1992 from 13 population-based cancer registries in nine European countries. Patients were followed up for life status and relapse. Ten-year observed survival was estimated by the Kaplan-Meier method. Cox multivariable analyses were performed separately for seminomas and non-seminomas. Overall, 66% of seminomas and 36% of non-seminomas were limited to the testis. Ten-year survival was 63% (Estonia) to 94% (Switzerland, Slovenia) for seminoma; 47% (Estonia) to 90% (Yorkshire, UK, The Netherlands) for non-seminoma. Multivariable analysis adjusted for country, age and stage showed that hazard ratios (HRs) of death differed little between western European registries, and were mainly attributable to differing stage at diagnosis. Significantly higher than reference HRs in Estonia and Poland suggest inadequacy or unavailability of treatments.
Sant
Milena
M
Department of Preventive and Predictive Medicine, Unit of Etiological Epidemiology and Prevention, Istituto Nazionale per lo Studio e la Cura dei Tumori, Via Venezian 1, Milan I-20133, Italy. milena.sant@istitutotumori.mi.it
Aareleid
Tiiu
T
Artioli
Maria Elisa
ME
Berrino
Franco
F
Coebergh
Jan Willem
JW
Colonna
Marc
M
Forman
David
D
Hedèlin
Guy
G
Rachtan
Jadwiga
J
Lutz
Jean Michel
JM
Otter
Renée
R
Raverdy
Nicole
N
Plesko I
Ivan
I
Primic
Maja-Zakelj
MZ
Tagliabue
Giovanna
G
D000328:Adult; D000368:Aged; D005060:Europe / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000401:mortality*; D012042:Registries; D012307:Risk Factors; D018239:Seminoma / Q000401:mortality*; D016019:Survival Analysis; D013736:Testicular Neoplasms / Q000401:mortality*