title: Lack of benefit of early awareness to age-related macular degeneration.
abstract: OBJECTIVE
  To assess the rate of early awareness to the presence of age-related macular degeneration (AMD) and whether it enables early detection of transition to neovascular AMD (NVAMD) as compared with patients whose first presentation to an ophthalmologist is already at the neovascular stage of disease.
  
  
  METHODS
  A retrospective analysis of 268 eyes of 268 consecutive patients with newly diagnosed NVAMD that were treated in a tertiary referral centre was performed. Patients were classified into those who were unaware (Group 1), or aware (Group 2), of the fact that they had AMD before diagnosis of NVAMD. Visual acuity, lesion size and composition, and demographics were compared between both groups.
  
  
  RESULTS
  In all, 185 patients (69%) and 83 patients (31%) were classified to Groups 1 and 2, respectively. Patients in Groups 1 and 2 had similar demographic characteristics, presenting visual acuity and lesion size, and lesion compositions. Group 1 patients were more likely to have a positive history for smoking (41 vs26% in Group 2, P=0.03), whereas Group 2 patients were more likely to have positive family history for AMD (20 vs10%, P=0.02).
  
  
  CONCLUSIONS
  These data suggest that current screening methods fail to identify the majority of patients with AMD before the development of NVAMD. The findings also demonstrate that in the routine clinical setting, prior awareness of AMD may not facilitate early detection of treatable choroidal neovascularization lesions.
authors.affiliation: Department of Ophthalmology, Hadassah - Hebrew University Medical Center, Jerusalem, Israel.
authors.forename: R A
authors.initials: RA
authors.lastname: Cervantes-Castañeda
authors.forename: E
authors.initials: E
authors.lastname: Banin
authors.forename: I
authors.initials: I
authors.lastname: Hemo
authors.forename: M
authors.initials: M
authors.lastname: Shpigel
authors.forename: E
authors.initials: E
authors.lastname: Averbukh
authors.forename: I
authors.initials: I
authors.lastname: Chowers
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D020256:Choroidal Neovascularization / Q000175:diagnosis* / Q000188:drug therapy / Q000235:genetics; D015331:Cohort Studies; D042241:Early Diagnosis; D005260:Female; D006801:Humans; D008268:Macular Degeneration / Q000175:diagnosis* / Q000188:drug therapy / Q000235:genetics; D008297:Male; D008875:Middle Aged; D010778:Photochemotherapy / Q000379:methods*; D011379:Prognosis; D012189:Retrospective Studies; D014792:Visual Acuity / Q000235:genetics