title: Dental and facial bone abnormalities in pyknodysostosis: CT findings.
abstract: Pyknodysostosis is an autosomal-recessive disorder of osteoclast dysfunction causing osteosclerosis, with associated maxillofacial anomalies. Multidetector CT with multiplanar and 3D reconstruction illustrated the pathologic findings in this case. Abnormalities included multiple retained deciduous teeth, unerupted teeth with associated follicles, an irregularly expanded alveolus and body of the mandible, and an obtuse mandibular angle. Volume-rendered imaging better delineated the irregular dentition, with crowding and retention of deciduous teeth.
authors.affiliation: Department of Radiology, Boston University Medical Center, Boston, MA, USA. keithwfleming@gmail.com
authors.forename: K W
authors.initials: KW
authors.lastname: Fleming
authors.forename: G
authors.initials: G
authors.lastname: Barest
authors.forename: O
authors.initials: O
authors.lastname: Sakai
mesh_terms: D000328:Adult; D002869:Chromosome Aberrations; D005808:Genes, Recessive / Q000235:genetics; D006801:Humans; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional; D008297:Male; D008310:Malocclusion / Q000000981:diagnostic imaging* / Q000235:genetics; D008334:Mandible / Q000000981:diagnostic imaging; D008342:Mandibulofacial Dysostosis / Q000000981:diagnostic imaging* / Q000235:genetics; D008437:Maxilla / Q000000981:diagnostic imaging; D008844:Micrognathism / Q000000981:diagnostic imaging; D010022:Osteopetrosis / Q000000981:diagnostic imaging* / Q000235:genetics; D010026:Osteosclerosis / Q000000981:diagnostic imaging* / Q000235:genetics; D011862:Radiography, Panoramic; D013577:Syndrome; D014057:Tomography, X-Ray Computed; D014071:Tooth Abnormalities / Q000000981:diagnostic imaging* / Q000235:genetics; D014094:Tooth, Deciduous / Q000000981:diagnostic imaging; D014097:Tooth, Unerupted / Q000000981:diagnostic imaging* / Q000235:genetics