Cellular damage in bacterial meningitis: an interplay of bacterial and host driven toxicity.
Bacterial meningitis is still an important infectious disease causing death and disability. Invasive bacterial infections of the CNS generate some of the most powerful inflammatory responses known in medicine. Although the components of bacterial cell surfaces are now chemically defined in exquisite detail and the interaction with several receptor pathways has been discovered, it is only very recently that studies combining these advanced biochemical and cell biological tools have been done. Additional to the immunological response direct bacterial toxicity has been identified as an important contributor to neuronal damage. A detailed understanding of the complex interaction of bacterial toxicity and host response may generate opportunities for innovative and specific neuroprotective therapies.
Weber
Joerg R
JR
Department of Cell Biology and Neurobiology, Charité - Universitaetsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany. joerg.weber@charite.de
Tuomanen
Elaine I
EI
D000818:Animals; D001419:Bacteria / Q000472:pathogenicity*; D001424:Bacterial Infections / Q000150:complications*; D001427:Bacterial Toxins / Q000633:toxicity*; D001812:Blood-Brain Barrier / Q000503:physiopathology; D006801:Humans; D007249:Inflammation / Q000209:etiology / Q000503:physiopathology; D007962:Leukocytes / Q000378:metabolism / Q000473:pathology; D016920:Meningitis, Bacterial / Q000209:etiology* / Q000473:pathology*; D018384:Oxidative Stress
D001427:Bacterial Toxins