Translational research in stroke: taking advances in the pathophysiology and treatment of stroke from the experimental setting to clinical trials.
Many advances have occurred regarding an increased understanding of the basic pathophysiology of ischemic brain injury that could lead to enhanced therapy for this disorder. Among the more important basic science advances are enhanced knowledge of the components of the ischemic cascade, the phenomenon of ischemic preconditioning, the potential relevance of hibernation, studies on gene expression in ischemic tissue, and imaging identification of the ischemic penumbra. The large number of unsuccessful prior clinical trials with a wide range of purported acute stroke therapies has provided many insights and lessons regarding how to perform better trials in the future. Translating these basic science and clinical trial design advances into effective and safe therapies will require increased interaction and cooperation between basic scientists and clinical researchers.
Fisher
Marc
M
Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01605, USA. fisherm@ummhc.org
Henninger
Nils
N
D000818:Animals; D002545:Brain Ischemia / Q000503:physiopathology / Q000628:therapy; D002986:Clinical Trials as Topic; D004195:Disease Models, Animal; D006801:Humans; D012106:Research; D020521:Stroke / Q000503:physiopathology* / Q000628:therapy*