Allogeneic bone marrow transplant for refractory mediastinal germ cell tumour: possible evidence of graft-versus-tumour effect.
Mediastinal germ cell tumours (GCT) carry a poor prognosis, particularly after relapse. We have reviewed the published reports of current treatments and describe a case with a cure after an allogeneic bone marrow transplant, which is not reported in the current published data. We believe that GCT may be susceptible to a graft-versus-tumour effect and suggest that patients with relapsed GCT be considered for allogeneic transplantation.
Goodwin
A
A
Westmead Hospital Medical Oncology Department, Westmead Hospital, Westmead, NSW, Australia. annabeg@westgate.wh.usyd.edu.au
Gurney
H
H
Gottlieb
D
D
D000328:Adult; D016026:Bone Marrow Transplantation / Q000379:methods*; D020350:Graft vs Tumor Effect; D006801:Humans; D008297:Male; D008479:Mediastinal Neoplasms / Q000601:surgery*; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis / Q000601:surgery; D009373:Neoplasms, Germ Cell and Embryonal / Q000601:surgery*; D014184:Transplantation, Homologous