title: Regional changes in reactive hyperemic blood flow during exercise training: time-course adaptations.
abstract: BACKGROUND
  Few studies have examined the time-course of localized exercise training on regional blood flow in humans. The study examined the influence of handgrip exercise training on forearm reactive hyperemic blood flow and vascular resistance in apparently healthy men.
  
  
  METHODS
  Forearm blood flow and vascular resistance were evaluated, in 17 individuals [Age: 22.6 +/- 3.5], in both arms, at rest and following 5 minutes of arterial occlusion, using strain gauge plethysmography, prior to training (V1) and every week thereafter (V2-5) for 4 weeks. Handgrip exercise was performed in the non-dominant arm 5 d/wk for 20 minutes at 60% of maximum voluntary contraction, while the dominant arm served as control.
  
  
  RESULTS
  Resting HR, BP, and forearm blood flow and vascular resistance were not altered with training. The trained arm handgrip strength and circumference increased by 14.5% (p = 0.014) and 1.56% (p = 0.03), respectively. ANOVA tests revealed an arms by visit interaction for the trained arm for reactive hyperemic blood flow (p = 0.02) and vascular resistance (p = 0.009). Post-hoc comparison demonstrated increased reactive hyperemic blood flow (p = 0.0013), and decreased post-occlusion vascular resistance (p = 0.05), following the 1st week of training, with no significant changes in subsequent visits.
  
  
  CONCLUSIONS
  The results indicate unilateral improvements in forearm reactive hyperemic blood flow and vascular resistance following 1 week of handgrip exercise training and leveled off for the rest of the study.
authors.affiliation: Department of Allied Medical Sciences, Jordan University of Science & Technology, Irbid, Jordan.
authors.forename: Mahmoud A
authors.initials: MA
authors.lastname: Alomari
authors.affiliation: Department of Kinesiology, Louisiana State University, Baton Rouge, Louisiana, USA.
authors.forename: Michael A
authors.initials: MA
authors.lastname: Welsch