Anti-ulcer treatment during pregnancy induces food allergy in mouse mothers and a Th2-bias in their offspring.
The treatment of dyspeptic disorders with anti-acids leads to an increased risk of sensitization against food allergens. As these drugs are taken by 30-50% of pregnant women due to reflux and heartburn, we aimed here to investigate the impact of maternal therapy with anti-acids on the immune response in the offspring in a murine model. Codfish extract as model allergen was fed with or without sucralfate, an anti-acid drug, to pregnant BALB/c mice during pregnancy and lactation. These mothers developed a codfish-specific allergic response shown as high IgG1 and IgE antibody levels and positive skin tests. In the next step we analyzed whether this maternal sensitization impacts a subsequent sensitization in the offspring. Indeed, in stimulated splenocytes of these offspring we found a relative Th2-dominance, because the Th1- and T-regulatory cytokines were significantly suppressed. Our data provide evidence that the anti-acid drug sucralfate supports sensitization against food in pregnant mice and favors a Th2-milieu in their offspring. From these results we propose that anti-acid treatment during pregnancy could be responsible for the increasing number of sensitizations against food allergens in young infants.
Schöll
Isabella
I
Department of Pathophysiology, Medical University of Vienna, Währinger Gürtel1090 Vienna, Austria.
Ackermann
Ute
U
Ozdemir
Cevdet
C
Blümer
Nicole
N
Dicke
Tanja
T
Sel
Serdar
S
Sel
Sarper
S
Wegmann
Michael
M
Szalai
Krisztina
K
Knittelfelder
Regina
R
Untersmayr
Eva
E
Scheiner
Otto
O
Garn
Holger
H
Jensen-Jarolim
Erika
E
Renz
Harald
H
D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D005260:Female; D005512:Food Hypersensitivity / Q000175:diagnosis* / Q000209:etiology*; D007371:Interferon-gamma / Q000378:metabolism; D016753:Interleukin-10 / Q000378:metabolism; D008297:Male; D018811:Maternal Exposure; D051379:Mice; D008807:Mice, Inbred BALB C; D011247:Pregnancy; D011270:Pregnancy, Animal; D051381:Rats; D013392:Sucralfate / Q000737:chemistry; D018418:Th2 Cells / Q000166:cytology*
D000897:Anti-Ulcer Agents; D016753:Interleukin-10; D013392:Sucralfate; D007371:Interferon-gamma