title: The Driselase-treated fraction of rice bran is a more effective dietary factor to improve hypertension, glucose and lipid metabolism in stroke-prone spontaneously hypertensive rats compared to ferulic acid.
abstract: The aim of this study is to investigate the effects of dietary supplementation with the Driselase-treated fraction (DF) of rice bran and ferulic acid (FA) on hypertension and glucose and lipid metabolism in stroke-prone spontaneously hypertensive rats (SHRSP). Male SHRSP at 4 weeks of age were divided into three groups, and for 8 weeks were fed (1) a control diet based on AIN-93M, (2) a DF of rice bran-supplemented diet at 60 g/kg and (3) an FA-supplemented diet at 0.01 g/kg. Means and standard errors were calculated and the data were tested by one-way ANOVA followed by a least significance difference test. The results showed that both the DF and FA diets significantly improved hypertension as well as glucose tolerance, plasma nitric oxide (NOx), urinary 8-hydroxy-2'-deoxyguanosine and other parameters. In particular, compared to the FA diet, the DF diet produced a significant improvement in urinary NOx, hepatic triacylglycerol and several mRNA expressions of metabolic parameters involved in glucose and lipid metabolisms. The results of the metabolic syndrome-related parameters obtained from this study suggest that the DF diet is more effective than the FA diet.
authors.affiliation: Department of Science of Food Function and Health, Tohoku University, Japan. ardy@biochem.tohoku.ac.jp
authors.lastname: Ardiansyah
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Shirakawa
authors.forename: Takuya
authors.initials: T
authors.lastname: Koseki
authors.forename: Katsumi
authors.initials: K
authors.lastname: Hashizume
authors.forename: Michio
authors.initials: M
authors.lastname: Komai
mesh_terms: D000080242:8-Hydroxy-2'-Deoxyguanosine; D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology; D015415:Biomarkers / Q000097:blood / Q000652:urine; D001786:Blood Glucose / Q000378:metabolism; D003373:Coumaric Acids / Q000494:pharmacology; D003849:Deoxyguanosine / Q000031:analogs & derivatives / Q000652:urine; D004043:Dietary Fiber / Q000008:administration & dosage*; D005656:Fungal Proteins / Q000494:pharmacology*; D005951:Glucose Tolerance Test; D006026:Glycoside Hydrolases / Q000494:pharmacology*; D006973:Hypertension / Q000178:diet therapy* / Q000378:metabolism; D007668:Kidney / Q000378:metabolism; D050356:Lipid Metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D009569:Nitric Oxide / Q000378:metabolism; D012275:Oryza / Q000187:drug effects*; D007703:Peptidyl-Dipeptidase A / Q000097:blood; D012333:RNA, Messenger / Q000032:analysis; D051381:Rats; D011918:Rats, Inbred SHR; D020133:Reverse Transcriptase Polymerase Chain Reaction; D020521:Stroke / Q000378:metabolism / Q000517:prevention & control
chemical_list: D000959:Antihypertensive Agents; D015415:Biomarkers; D001786:Blood Glucose; D003373:Coumaric Acids; D004043:Dietary Fiber; D005656:Fungal Proteins; D012333:RNA, Messenger; D009569:Nitric Oxide; D000080242:8-Hydroxy-2'-Deoxyguanosine; C004999:ferulic acid; D006026:Glycoside Hydrolases; C035212:driselase; D007703:Peptidyl-Dipeptidase A; D003849:Deoxyguanosine