Draft genome sequence of the sexually transmitted pathogen Trichomonas vaginalis.
We describe the genome sequence of the protist Trichomonas vaginalis, a sexually transmitted human pathogen. Repeats and transposable elements comprise about two-thirds of the approximately 160-megabase genome, reflecting a recent massive expansion of genetic material. This expansion, in conjunction with the shaping of metabolic pathways that likely transpired through lateral gene transfer from bacteria, and amplification of specific gene families implicated in pathogenesis and phagocytosis of host proteins may exemplify adaptations of the parasite during its transition to a urogenital environment. The genome sequence predicts previously unknown functions for the hydrogenosome, which support a common evolutionary origin of this unusual organelle with mitochondria.
Carlton
Jane M
JM
Institute for Genomic Research, 9712 Medical Research Drive, Rockville, MD 20850, USA. jane.carlton@med.nyu.edu
Hirt
Robert P
RP
Silva
Joana C
JC
Delcher
Arthur L
AL
Schatz
Michael
M
Zhao
Qi
Q
Wortman
Jennifer R
JR
Bidwell
Shelby L
SL
Alsmark
U Cecilia M
UC
Besteiro
Sébastien
S
Sicheritz-Ponten
Thomas
T
Noel
Christophe J
CJ
Dacks
Joel B
JB
Foster
Peter G
PG
Simillion
Cedric
C
Van de Peer
Yves
Y
Miranda-Saavedra
Diego
D
Barton
Geoffrey J
GJ
Westrop
Gareth D
GD
Müller
Sylke
S
Dessi
Daniele
D
Fiori
Pier Luigi
PL
Ren
Qinghu
Q
Paulsen
Ian
I
Zhang
Hanbang
H
Bastida-Corcuera
Felix D
FD
Simoes-Barbosa
Augusto
A
Brown
Mark T
MT
Hayes
Richard D
RD
Mukherjee
Mandira
M
Okumura
Cheryl Y
CY
Schneider
Rachel
R
Smith
Alias J
AJ
Vanacova
Stepanka
S
Villalvazo
Maria
M
Haas
Brian J
BJ
Pertea
Mihaela
M
Feldblyum
Tamara V
TV
Utterback
Terry R
TR
Shu
Chung-Li
CL
Osoegawa
Kazutoyo
K
de Jong
Pieter J
PJ
Hrdy
Ivan
I
Horvathova
Lenka
L
Zubacova
Zuzana
Z
Dolezal
Pavel
P
Malik
Shehre-Banoo
SB
Logsdon
John M
JM
Henze
Katrin
K
Gupta
Arti
A
Wang
Ching C
CC
Dunne
Rebecca L
RL
Upcroft
Jacqueline A
JA
Upcroft
Peter
P
White
Owen
O
Salzberg
Steven L
SL
Tang
Petrus
P
Chiu
Cheng-Hsun
CH
Lee
Ying-Shiung
YS
Embley
T Martin
TM
Coombs
Graham H
GH
Mottram
Jeremy C
JC
Tachezy
Jan
J
Fraser-Liggett
Claire M
CM
Johnson
Patricia J
PJ
D000818:Animals; D001692:Biological Transport / Q000235:genetics; D004251:DNA Transposable Elements; D016054:DNA, Protozoan / Q000235:genetics; D022761:Gene Transfer, Horizontal; D017125:Genes, Protozoan; D018503:Genome, Protozoan; D006801:Humans; D006859:Hydrogen / Q000378:metabolism; D053858:Metabolic Networks and Pathways / Q000235:genetics; D008969:Molecular Sequence Data; D005810:Multigene Family; D015388:Organelles / Q000378:metabolism; D018384:Oxidative Stress / Q000235:genetics; D010447:Peptide Hydrolases / Q000235:genetics / Q000378:metabolism; D015800:Protozoan Proteins / Q000235:genetics / Q000502:physiology; D012323:RNA Processing, Post-Transcriptional; D012091:Repetitive Sequences, Nucleic Acid; D017422:Sequence Analysis, DNA; D012749:Sexually Transmitted Diseases / Q000469:parasitology; D014245:Trichomonas Infections / Q000469:parasitology / Q000635:transmission; D014246:Trichomonas vaginalis / Q000166:cytology / Q000235:genetics* / Q000378:metabolism / Q000472:pathogenicity
D004251:DNA Transposable Elements; D016054:DNA, Protozoan; D015800:Protozoan Proteins; D006859:Hydrogen; D010447:Peptide Hydrolases