title: First report of plasmid-mediated qnrA1 in a ciprofloxacin-resistant Escherichia coli strain in Latin America.
abstract: Among 144 ciprofloxacin-resistant Escherichia coli isolated in Brazil, one (0.69%) QnrA1-producing isolate was detected. The qnrA1 gene was associated with ISCR1. The QnrA1 determinant was carried on a 41-kb conjugative plasmid, which also carried a FOX-type cephalosporinase encoding gene and a class 1 integron with the aadB and catB3 cassettes. This is the first report of a qnrA-carrying isolate in a Latin American country.
authors.affiliation: Laboratório ALERTA, Universidade Federal de São Paulo, Rua Pedro de Toledo, 781 6o Andar, São Paulo, SP, and Unidade de Microbiologia, Serviço de Patologia Clínica, Hospital de Clínicas, Porto Alegre, RS, Brazil. maricastanh@yahoo.com
authors.forename: Mariana
authors.initials: M
authors.lastname: Castanheira
authors.forename: Andrea S
authors.initials: AS
authors.lastname: Pereira
authors.forename: Adriana G
authors.initials: AG
authors.lastname: Nicoletti
authors.forename: Antônio C C
authors.initials: AC
authors.lastname: Pignatari
authors.forename: Afonso L
authors.initials: AL
authors.lastname: Barth
authors.forename: Ana C
authors.initials: AC
authors.lastname: Gales
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002939:Ciprofloxacin / Q000494:pharmacology*; D003227:Conjugation, Genetic; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D004926:Escherichia coli / Q000201:enzymology / Q000235:genetics / Q000302:isolation & purification; D004927:Escherichia coli Infections / Q000382:microbiology; D029968:Escherichia coli Proteins / Q000502:physiology*; D032023:Integrons / Q000235:genetics; D007843:Latin America / Q000453:epidemiology; D008969:Molecular Sequence Data; D010957:Plasmids / Q000235:genetics*
chemical_list: D000900:Anti-Bacterial Agents; D029968:Escherichia coli Proteins; C485384:Qnr protein, E coli; D002939:Ciprofloxacin