title: The role of extracellular matrix in CNS regeneration.
abstract: Chondroitin sulfate proteoglycans are the principal inhibitory component of glial scars, which form after damage to the adult central nervous system and act as a barrier to regenerating axons. Recent findings have furthered our understanding of the mechanisms that result in a failure of regeneration after spinal cord injury and suggest that a multipartite approach will be required to facilitate long-distance regeneration and functional recovery.
authors.affiliation: Case Western Reserve University School of Medicine, Department of Neurosciences, 2109 Adelbert Road E-658, Cleveland, Ohio 44106, USA.
authors.forename: Sarah A
authors.initials: SA
authors.lastname: Busch
authors.forename: Jerry
authors.initials: J
authors.lastname: Silver
mesh_terms: D000818:Animals; D002490:Central Nervous System / Q000293:injuries / Q000378:metabolism* / Q000503:physiopathology; D011508:Chondroitin Sulfate Proteoglycans / Q000378:metabolism*; D002921:Cicatrix / Q000378:metabolism / Q000503:physiopathology / Q000517:prevention & control; D005109:Extracellular Matrix / Q000378:metabolism*; D005911:Gliosis / Q000378:metabolism / Q000503:physiopathology / Q000517:prevention & control; D020439:Growth Cones / Q000378:metabolism / Q000648:ultrastructure; D006131:Growth Inhibitors / Q000378:metabolism; D006801:Humans; D009416:Nerve Regeneration / Q000502:physiology*; D013119:Spinal Cord Injuries / Q000378:metabolism* / Q000503:physiopathology / Q000628:therapy
chemical_list: D011508:Chondroitin Sulfate Proteoglycans; D006131:Growth Inhibitors