Immunohistochemical expression of p53, Bcl-2, COX-2, C-erb-B2, EPO-R, beta-catenin, and E-cadherin in non tumoral gastric mucous membrane.
Different authors have investigated the immunohistochemical expression of some proteins in the adenocarcinoma of the stomach, including cell cycle regulators proteins like p53 and Bcl-2; growth factors (c-erb-B2 and EPO-R); angiogenesis-related markers such as COX-2 and cellular adhesion molecules (beta-catenin and E-cadherin). While these proteins have been studied in gastric adenocarcinoma, their immunophenotyping in non tumoral gastric mucous membrane remains unexplored. In the present study, we investigated the expression, function and behavior of these proteins in normal gastric mucous membrane to contribute to gain further knowledge on the significance of their loss or overexpression in malignant gastric tumors.
Sereno
M
M
Medical Oncology Department, La Paz Hospital, Paseo de la Castellana, 261 CP: 28046 Madrid, Spain. mariasereno@yahoo.es
García-Cabezas
M A
MA
De Castro
J
J
Cejas
P
P
Saenz
E Casado
EC
Belda-Iniesta
C
C
Feijoo
J Barriuso
JB
Larrauri
J
J
Nistal
M
M
Baron
M Gonzalez
MG
D015415:Biomarkers / Q000378:metabolism; D015820:Cadherins / Q000378:metabolism; D051546:Cyclooxygenase 2 / Q000378:metabolism; D005260:Female; D005753:Gastric Mucosa / Q000033:anatomy & histology / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008565:Membrane Proteins / Q000378:metabolism; D008875:Middle Aged; D011506:Proteins / Q000378:metabolism*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000378:metabolism; D017467:Receptors, Erythropoietin / Q000378:metabolism; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism; D051176:beta Catenin / Q000378:metabolism
D015415:Biomarkers; D015820:Cadherins; D051546:Cyclooxygenase 2; D008565:Membrane Proteins; D011506:Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D018719:Erb-b2 Receptor Tyrosine Kinases; D017467:Receptors, Erythropoietin; D016159:Tumor Suppressor Protein p53; D051176:beta Catenin; C495270:CTNNB1 protein, human; C496540:PTGS2 protein, human