No evidence for an mtDNA role in sperm motility: data from complete sequencing of asthenozoospermic males.
The first complete mitochondrial DNA (mtDNA) sequences (approximately 16,569 bp) in 20 patients with asthenozoospermia and a comparison with 23 new complete mtDNA sequences in teratoasthenozoospermic individuals, confirmed no sharing of specific polymorphisms or specific mitochondrial lineages between these individuals. This is strong evidence against the accepted claim of a major role played by mtDNA in male fertility, once supported by haplogroup association studies based on the screening of hypervariable region I. The hypothesis of maternally driven selection acting in male reproductive success must thus be treated with caution.
Pereira
Luísa
L
Instituto de Patologia e Imunologia Molecular da Universidade do Porto, (IPATIMUP), Porto, Portugal. lpereira@ipatimup.pt
Gonçalves
João
J
Franco-Duarte
Ricardo
R
Silva
Júlia
J
Rocha
Tiago
T
Arnold
Christiane
C
Richards
Martin
M
Macaulay
Vincent
V
D000704:Analysis of Variance; D053627:Asthenozoospermia / Q000235:genetics*; D001483:Base Sequence; D004272:DNA, Mitochondrial / Q000235:genetics*; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D010802:Phylogeny; D011174:Portugal; D017422:Sequence Analysis, DNA; D013081:Sperm Motility / Q000235:genetics*
D004272:DNA, Mitochondrial