title: Autophagy regulates ageing in C. elegans.
abstract: The role of autophagy in ageing regulation has been suggested based on studies in C. elegans, in which knockdown of the expression of bec-1 (ortholog of the yeast and mammalian autophagy genes ATG6/VPS30 and beclin 1, respectively) shortens lifespan of the daf-2(e1370) mutant C. elegans. However, Beclin1/ATG6 is also known to be involved in other cellular functions in addition to autophagy. In the current study, we knocked down two other autophagy genes, atg-7 and atg-12, in C. elegans using RNAi. We showed that RNAi shortened the lifespan of both wild type and daf-2 mutant C. elegans, providing strong support for a role of autophagy in ageing regulation.
authors.affiliation: Department of Pharmacology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA.
authors.forename: Eszter S
authors.initials: ES
authors.lastname: Hars
authors.forename: Haiyan
authors.initials: H
authors.lastname: Qi
authors.forename: Alexey G
authors.initials: AG
authors.lastname: Ryazanov
authors.forename: Shengkan
authors.initials: S
authors.lastname: Jin
authors.forename: Li
authors.initials: L
authors.lastname: Cai
authors.forename: Chengcheng
authors.initials: C
authors.lastname: Hu
authors.forename: Leroy F
authors.initials: LF
authors.lastname: Liu
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D001343:Autophagy / Q000502:physiology*; D017173:Caenorhabditis elegans / Q000502:physiology*; D029742:Caenorhabditis elegans Proteins / Q000235:genetics / Q000378:metabolism; D008136:Longevity / Q000502:physiology*; D016016:Proportional Hazards Models; D034622:RNA Interference; D016019:Survival Analysis
chemical_list: D029742:Caenorhabditis elegans Proteins