title: Enantioselective total synthesis of (-)-erinacine B.
abstract: The first enantioselective total synthesis of (-)-erinacine B has been achieved. Our approach features convergent construction of the 5-6-7 tricyclic cyathane core system via chiral building blocks prepared using asymmetric catalysis developed by us and highly stereoselective construction of all stereogenic centers in the aglycon. [reaction: see text].
authors.affiliation: Department of Chemistry, Faculty of Science and Engineering, Waseda University, 3-4-1, Ohkubo, Shinjuku, Tokyo 169-8555, Japan.
authors.forename: Hideaki
authors.initials: H
authors.lastname: Watanabe
authors.forename: Masashi
authors.initials: M
authors.lastname: Takano
authors.forename: Akinori
authors.initials: A
authors.lastname: Umino
authors.forename: Toshiya
authors.initials: T
authors.lastname: Ito
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Ishikawa
authors.forename: Masahisa
authors.initials: M
authors.lastname: Nakada
mesh_terms: D002384:Catalysis; D004224:Diterpenes / Q000737:chemistry*; D006576:Heterocyclic Compounds, 4 or More Rings / Q000138:chemical synthesis* / Q000737:chemistry; D007659:Ketones / Q000737:chemistry*; D008968:Molecular Conformation; D012441:Saccharomyces cerevisiae / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D004224:Diterpenes; D006576:Heterocyclic Compounds, 4 or More Rings; D007659:Ketones; C497675:cyathane; C518057:erinacine B