Sexual function in persons with inflammatory bowel disease: a survey with matched controls.
OBJECTIVE
Sexual problems as a result of inflammatory bowel diseases (IBDs) play an important role in patients' worries and concerns. We aimed to evaluate sexual function in men and women with IBD relative to healthy controls.


METHODS
A random sample of the national patients organization was surveyed (n = 1000). Age- and sex-matched friends were used as controls; in addition, controls were selected from a large health insurance cohort. Sexual function was evaluated using the Erectile Index of Erectile Function, and the Brief Index of Sexual Function in Women; impaired function was defined as a score less than -1 on a z-normalized scale. The results are reported as age-adjusted odds ratios with 95% confidence intervals based on conditional logistic regression.


RESULTS
The response rate was 41% in cases. Overall, 153 male and 181 female matched pairs were available for analysis. The proportion of patients who were married, had a partner, and were sexually active were similar between cases and controls. Depression was the most important determinant of impaired sexual function. Men with IBD in remission or mild activity had similar Erectile Index of Erectile Function scores as compared with controls. Comorbidity and antihypertensive therapy impacted on single subscores. Women with IBD showed impaired function irrespective of disease activity as compared with healthy controls. Results in women varied by type of control. High socioeconomic status was a protective factor for several subscores in women.


CONCLUSIONS
Depression is the most important determinant of low sexual function.
Timmer
Antje
A
Department of Internal Medicine I, University of Regensburg, Regensburg, Germany. timmer@cochrane.de
Bauer
Alexandra
A
Dignass
Axel
A
Rogler
Gerhard
G
D000293:Adolescent; D000328:Adult; D000368:Aged; D000959:Antihypertensive Agents / Q000009:adverse effects; D016022:Case-Control Studies; D003863:Depression / Q000453:epidemiology; D005260:Female; D005858:Germany / Q000453:epidemiology; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000503:physiopathology* / Q000523:psychology; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D010817:Physician-Patient Relations; D011569:Psychiatric Status Rating Scales; D012737:Sex Factors; D012725:Sexual Behavior / Q000502:physiology*; D011795:Surveys and Questionnaires
D000959:Antihypertensive Agents