title: Comment on "A common genetic variant is associated with adult and childhood obesity".
abstract: Contrary to the findings of Herbert et al. (Reports, 14 April 2006, p. 279), homozygous carriers of the C allele of the rs7566605 variant near the INSIG2 gene did not exhibit a significantly increased risk for obesity in a large population-based cross-sectional German study. A subgroup analysis, however, revealed that this allele significantly increased the risk for obesity in already overweight individuals.
authors.affiliation: Institute of Pharmacology, Ernst Moritz Arndt University of Greifswald, Germany. dieter.rosskopf@uni-greifswald.de
authors.forename: Dieter
authors.initials: D
authors.lastname: Rosskopf
authors.forename: Alexa
authors.initials: A
authors.lastname: Bornhorst
authors.forename: Christian
authors.initials: C
authors.lastname: Rimmbach
authors.forename: Christian
authors.initials: C
authors.lastname: Schwahn
authors.forename: Alexander
authors.initials: A
authors.lastname: Kayser
authors.forename: Anne
authors.initials: A
authors.lastname: Krüger
authors.forename: Grietje
authors.initials: G
authors.lastname: Tessmann
authors.forename: Ingrid
authors.initials: I
authors.lastname: Geissler
authors.forename: Heyo K
authors.initials: HK
authors.lastname: Kroemer
authors.forename: Henry
authors.initials: H
authors.lastname: Völzke
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D005838:Genotype; D005858:Germany; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics* / Q000502:physiology; D008297:Male; D008565:Membrane Proteins / Q000235:genetics* / Q000502:physiology; D008875:Middle Aged; D009765:Obesity / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
chemical_list: C467727:INSIG2 protein, human; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins