title: Diet and risk of ovarian cancer in the California Teachers Study cohort.
abstract: Dietary phytochemical compounds, including isoflavones and isothiocyanates, may inhibit cancer development but have not yet been examined in prospective epidemiologic studies of ovarian cancer. The authors have investigated the association between consumption of these and other nutrients and ovarian cancer risk in a prospective cohort study. Among 97,275 eligible women in the California Teachers Study cohort who completed the baseline dietary assessment in 1995-1996, 280 women developed invasive or borderline ovarian cancer by December 31, 2003. Multivariable Cox proportional hazards regression, with age as the timescale, was used to estimate relative risks and 95% confidence intervals; all statistical tests were two sided. Intake of isoflavones was associated with lower risk of ovarian cancer. Compared with the risk for women who consumed less than 1 mg of total isoflavones per day, the relative risk of ovarian cancer associated with consumption of more than 3 mg/day was 0.56 (95% confidence interval: 0.33, 0.96). Intake of isothiocyanates or foods high in isothiocyanates was not associated with ovarian cancer risk, nor was intake of macronutrients, antioxidant vitamins, or other micronutrients. Although dietary consumption of isoflavones may be associated with decreased ovarian cancer risk, most dietary factors are unlikely to play a major role in ovarian cancer development.
authors.affiliation: Northern California Cancer Center, Fremont, CA 94538, USA. ellen@nccc.org
authors.forename: Ellen T
authors.initials: ET
authors.lastname: Chang
authors.forename: Valerie S
authors.initials: VS
authors.lastname: Lee
authors.forename: Alison J
authors.initials: AJ
authors.lastname: Canchola
authors.forename: Christina A
authors.initials: CA
authors.lastname: Clarke
authors.forename: David M
authors.initials: DM
authors.lastname: Purdie
authors.forename: Peggy
authors.initials: P
authors.lastname: Reynolds
authors.forename: Hoda
authors.initials: H
authors.lastname: Anton-Culver
authors.forename: Leslie
authors.initials: L
authors.lastname: Bernstein
authors.forename: Dennis
authors.initials: D
authors.lastname: Deapen
authors.forename: David
authors.initials: D
authors.lastname: Peel
authors.forename: Rich
authors.initials: R
authors.lastname: Pinder
authors.forename: Ronald K
authors.initials: RK
authors.lastname: Ross
authors.forename: Daniel O
authors.initials: DO
authors.lastname: Stram
authors.forename: Dee W
authors.initials: DW
authors.lastname: West
authors.forename: William
authors.initials: W
authors.lastname: Wright
authors.forename: Argyrios
authors.initials: A
authors.lastname: Ziogas
authors.forename: Pamela L
authors.initials: PL
authors.lastname: Horn-Ross
mesh_terms: D000328:Adult; D000368:Aged; D000975:Antioxidants / Q000008:administration & dosage; D002140:California / Q000453:epidemiology; D004032:Diet; D005260:Female; D006801:Humans; D007529:Isoflavones / Q000008:administration & dosage; D018977:Micronutrients / Q000008:administration & dosage; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000453:epidemiology* / Q000209:etiology; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012307:Risk Factors
chemical_list: D000975:Antioxidants; D007529:Isoflavones; D018977:Micronutrients