title: Dissociable contributions of MRI volume reductions of superior temporal and fusiform gyri to symptoms and neuropsychology in schizophrenia.
abstract: We sought to identify the functional correlates of reduced magnetic resonance imaging (MRI) volumes of the superior temporal gyrus (STG) and the fusiform gyrus (FG) in patients with chronic schizophrenia. MRI volumes, positive/negative symptoms, and neuropsychological tests of facial memory and executive functioning were examined within the same subjects. The results indicated two distinct, dissociable brain structure-function relationships: (1) reduced left STG volume-positive symptoms-executive deficits; (2) reduced left FG-negative symptoms-facial memory deficits. STG and FG volume reductions may each make distinct contributions to symptoms and cognitive deficits of schizophrenia.
authors.affiliation: Department of Psychology, University of Massachusetts, Boston, MA 02125-3393, United States. paul.nestor@umb.edu
authors.forename: Paul G
authors.initials: PG
authors.lastname: Nestor
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Onitsuka
authors.forename: Ronald J
authors.initials: RJ
authors.lastname: Gurrera
authors.forename: Margaret
authors.initials: M
authors.lastname: Niznikiewicz
authors.forename: Melissa
authors.initials: M
authors.lastname: Frumin
authors.forename: Martha E
authors.initials: ME
authors.lastname: Shenton
authors.forename: Robert W
authors.initials: RW
authors.lastname: McCarley
mesh_terms: D000293:Adolescent; D000328:Adult; D000339:Affect; D002908:Chronic Disease; D003072:Cognition Disorders / Q000175:diagnosis / Q000209:etiology*; D005145:Face; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008569:Memory Disorders / Q000175:diagnosis / Q000209:etiology; D008875:Middle Aged; D009483:Neuropsychological Tests; D012559:Schizophrenia / Q000150:complications* / Q000503:physiopathology*; D012720:Severity of Illness Index; D013702:Temporal Lobe / Q000033:anatomy & histology* / Q000503:physiopathology*