title: The Thr715Pro polymorphism of the P-selectin gene is not associated with ischemic stroke risk.
abstract: OBJECTIVE
  A Thr>Pro polymorphism at codon 715 in the coding region of the P-selectin gene has recently been described. Individuals carrying the Pro715 allele were reported to have a reduced risk of myocardial infarction. A possible association of this polymorphism with the risk of ischemic stroke is currently under discussion.
  
  
  METHODS
  We investigated the prevalence of the 715 Thr>Pro polymorphism in 450 patients aged younger than 60 years with ischemic stroke or transient ischemic attack and in 450 controls without vascular disease matched for age and gender. We also investigated possible interactions of the polymorphism with other vascular risk factors, stroke severity and stroke etiology.
  
  
  RESULTS
  The distribution of the two allelic variants of the 715Thr>Pro polymorphism did not differ significantly between patients and control subjects (78% versus 81% for Thr/Thr, 21% versus 18% for Thr/Pro and 1% versus 1% for Pro/Pro in patients and controls, respectively; adjusted odds ratio for carriers of the C allele: 1.0 [0.8 to 1.2; P=0.695]). We found no significant interaction of this polymorphism with vascular risk factors, stroke severity, or stroke etiology.
  
  
  CONCLUSIONS
  Our study supports results from previous investigation showing that the 715Thr>Pro polymorphism of the P-selectin gene was not associated with a risk or clinical characteristics of ischemic stroke.
authors.affiliation: Department of Neurology, Hospital Barmherzige Brueder, Vienna, Austria.
authors.forename: Julia
authors.initials: J
authors.lastname: Ferrari
authors.forename: Sandra
authors.initials: S
authors.lastname: Rieger
authors.forename: Georg
authors.initials: G
authors.lastname: Endler
authors.forename: Stefan
authors.initials: S
authors.lastname: Greisenegger
authors.forename: Marion
authors.initials: M
authors.lastname: Funk
authors.forename: Thomas
authors.initials: T
authors.lastname: Scholze
authors.forename: Wilfried
authors.initials: W
authors.lastname: Lang
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Lalouschek
authors.forename: Christine
authors.initials: C
authors.lastname: Mannhalter
mesh_terms: D000483:Alleles; D002545:Brain Ischemia / Q000453:epidemiology / Q000235:genetics*; D015331:Cohort Studies; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D019007:P-Selectin / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D015995:Prevalence; D011392:Proline / Q000235:genetics; D012042:Registries; D012307:Risk Factors; D020521:Stroke / Q000453:epidemiology / Q000235:genetics*; D013912:Threonine / Q000235:genetics
chemical_list: D019007:P-Selectin; D013912:Threonine; D011392:Proline