title: Ten-year survival and risk of relapse for testicular cancer: a EUROCARE high resolution study.
abstract: Effective treatments for testicular cancer have been available since the 1970s, yet EUROCARE uncovered marked inter-country survival differences for this disease. To investigate these differences, we reviewed clinical records of 1350 testicular cancer cases diagnosed during 1987-1992 from 13 population-based cancer registries in nine European countries. Patients were followed up for life status and relapse. Ten-year observed survival was estimated by the Kaplan-Meier method. Cox multivariable analyses were performed separately for seminomas and non-seminomas. Overall, 66% of seminomas and 36% of non-seminomas were limited to the testis. Ten-year survival was 63% (Estonia) to 94% (Switzerland, Slovenia) for seminoma; 47% (Estonia) to 90% (Yorkshire, UK, The Netherlands) for non-seminoma. Multivariable analysis adjusted for country, age and stage showed that hazard ratios (HRs) of death differed little between western European registries, and were mainly attributable to differing stage at diagnosis. Significantly higher than reference HRs in Estonia and Poland suggest inadequacy or unavailability of treatments.
authors.affiliation: Department of Preventive and Predictive Medicine, Unit of Etiological Epidemiology and Prevention, Istituto Nazionale per lo Studio e la Cura dei Tumori, Via Venezian 1, Milan I-20133, Italy. milena.sant@istitutotumori.mi.it
authors.forename: Milena
authors.initials: M
authors.lastname: Sant
authors.forename: Tiiu
authors.initials: T
authors.lastname: Aareleid
authors.forename: Maria Elisa
authors.initials: ME
authors.lastname: Artioli
authors.forename: Franco
authors.initials: F
authors.lastname: Berrino
authors.forename: Jan Willem
authors.initials: JW
authors.lastname: Coebergh
authors.forename: Marc
authors.initials: M
authors.lastname: Colonna
authors.forename: David
authors.initials: D
authors.lastname: Forman
authors.forename: Guy
authors.initials: G
authors.lastname: Hedèlin
authors.forename: Jadwiga
authors.initials: J
authors.lastname: Rachtan
authors.forename: Jean Michel
authors.initials: JM
authors.lastname: Lutz
authors.forename: Renée
authors.initials: R
authors.lastname: Otter
authors.forename: Nicole
authors.initials: N
authors.lastname: Raverdy
authors.forename: Ivan
authors.initials: I
authors.lastname: Plesko I
authors.forename: Maja-Zakelj
authors.initials: MZ
authors.lastname: Primic
authors.forename: Giovanna
authors.initials: G
authors.lastname: Tagliabue
mesh_terms: D000328:Adult; D000368:Aged; D005060:Europe / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000401:mortality*; D012042:Registries; D012307:Risk Factors; D018239:Seminoma / Q000401:mortality*; D016019:Survival Analysis; D013736:Testicular Neoplasms / Q000401:mortality*