title: [A case of HLA-B54 positive silicosis with rheumatoid arthritis and lung cancer].
abstract: In the same environment or workplace, some people contract pneumoconiosis, including silicosis, and some do not. This suggests the important role of constitutional predisposition. In Japanese cases with silicosis, the frequency of HLA-B54 was increased and disease susceptibility gene (s) may exist near the HLA-B locus. It is well known that silicosis is frequently accompanied with rheumatoid arthritis, probably due to the effects of silica on the immunological system. We encountered a case of silicosis with rheumatoid arthritis and lung cancer, who was found to have HLA-B54.
authors.affiliation: Division of Pulmonary Medicine, Department of Medicine, Jichi Medical University.
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Ishii
authors.forename: Yukihiko
authors.initials: Y
authors.lastname: Sugiyama
authors.forename: Masashi
authors.initials: M
authors.lastname: Bando
authors.forename: Shoji
authors.initials: S
authors.lastname: Ohno
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000150:complications*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000209:etiology*; D004334:Drug Administration Schedule; D015235:HLA-B Antigens / Q000032:analysis*; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy / Q000209:etiology*; D008297:Male; D012829:Silicosis / Q000150:complications* / Q000276:immunology
chemical_list: D015235:HLA-B Antigens; C113783:HLA-B54 antigen