title: [What's new at the maternal-foetal interface: role of the hCG/LH-hCG receptor couple during embryo implantation].
abstract: Implantation of the embryo into the maternal endometrium represents a unique biological process, combining an immunological (tolerance of an allograft) and biological (adhesion of two epitheliums) paradox. The success of implantation depends on a receptive endometrium, a functionally normal blastocyst and a synchronized cross-talk between embryonic and maternal tissues. Though sexual steroids control the process, a cascade of growth factors or cytokines are the prime paracrine mediators of the dialogue at the maternal-embryonic interface. HCG is one of the molecules most precociously produced by the embryo and is the most specific marker of its presence. HCG is a luteotropic factor which relays the inadequate support provided by the reduced rates of LH, but also influences the pregnancy on a paracrine mode by a local action on implantation process, probably by interacting with its receptor, the LH/hCG-R that we have evidenced on endometrial epithelium. We demonstrate that embryo actively participate into its implantation, tolerance and placentation.
authors.affiliation: Centre d'immunologie CHU, Département universitaire de Gynécologie et Obstétrique, CHR Citadelle, Liège, Belgique. sperrier@chrcitadelle.be
authors.forename: S
authors.initials: S
authors.lastname: Perrier d'Hauterive
authors.forename: C
authors.initials: C
authors.lastname: Charlet-Renard
authors.forename: M
authors.initials: M
authors.lastname: Dubois
authors.forename: J M
authors.initials: JM
authors.lastname: Foidart
authors.forename: V
authors.initials: V
authors.lastname: Geenen
mesh_terms: D006063:Chorionic Gonadotropin / Q000502:physiology*; D010064:Embryo Implantation / Q000502:physiology*; D005260:Female; D006801:Humans; D011247:Pregnancy; D011974:Receptors, LH / Q000502:physiology*
chemical_list: D006063:Chorionic Gonadotropin; D011974:Receptors, LH