Metabolism of linoleic acid by human gut bacteria: different routes for biosynthesis of conjugated linoleic acid.
A survey of 30 representative strains of human gram-positive intestinal bacteria indicated that Roseburia species were among the most active in metabolizing linoleic acid (cis-9,cis-12-18:2). Different Roseburia spp. formed either vaccenic acid (trans-11-18:1) or a 10-hydroxy-18:1; these compounds are precursors of the health-promoting conjugated linoleic acid cis-9,trans-11-18:2 in human tissues and the intestine, respectively.
Devillard
Estelle
E
Rowett Research Institute, Bucksburn, Aberdeen, AB21 9SB, United Kingdom.
McIntosh
Freda M
FM
Duncan
Sylvia H
SH
Wallace
R John
RJ
D000328:Adult; D006094:Gram-Positive Bacteria / Q000145:classification / Q000201:enzymology* / Q000378:metabolism; D006801:Humans; D007223:Infant; D007420:Intestine, Large / Q000382:microbiology*; D007535:Isomerases / Q000378:metabolism; D008041:Linoleic Acids / Q000378:metabolism*; D044243:Linoleic Acids, Conjugated / Q000096:biosynthesis*
D008041:Linoleic Acids; D044243:Linoleic Acids, Conjugated; D007535:Isomerases