title: Significant response of radiation induced CNS toxicity to high dose steroid administration.
abstract: Treatment of radiation myelopathy remains a challenge. Supportive and rehabilitative therapy is the mainstay of treatment. This article describes a case of central nervous system (CNS) toxicity of radiation with a progressive improvement in the clinicoradiological picture following high dose steroid treatment. A female patient was admitted to the neurology department of our hospital 7 months after a course of radiotherapy in another centre for lingual epidermoid cancer. Neurological examination revealed a heavy spastic quadriplegia syndrome. On MRI examination, T2 weighted hyperintensities were observed in cerebral and cerebellar peduncles, periventricular regions and medulla spinalis at Th1-Th2 levels. The patient was treated with high dose methylprednisolone, 1 g day(-1) for 5 days (pulse therapy) followed by oral methylprednisolone 80 mg day(-1) for a week, tapered over 3 weeks. Within the first week of pulse therapy, she regained muscle strength of upper limbs against gravity. At the 2 year follow-up, MRI demonstrated obvious regression of the lesions in the medulla and cerebellum with disappearance of contrast enhancement. This case report is notable with the complete disappearance of MRI lesions at the 2 year follow-up after the treatment with high dose steroid.
authors.affiliation: Department of Radiation Oncology, Meram Medical Faculty, Selcuk University,Akyokus, Konya, Turkey. minegenc@yahoo.com
authors.forename: M
authors.initials: M
authors.lastname: Genc
authors.forename: E
authors.initials: E
authors.lastname: Genc
authors.forename: B O
authors.initials: BO
authors.lastname: Genc
authors.forename: D A
authors.initials: DA
authors.lastname: Kiresi
mesh_terms: D001921:Brain / Q000473:pathology / Q000528:radiation effects; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000532:radiotherapy; D004334:Drug Administration Schedule; D005260:Female; D005500:Follow-Up Studies; D005938:Glucocorticoids / Q000008:administration & dosage* / Q000627:therapeutic use; D006801:Humans; D008279:Magnetic Resonance Imaging; D008775:Methylprednisolone / Q000008:administration & dosage* / Q000627:therapeutic use; D008875:Middle Aged; D011782:Quadriplegia / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D011832:Radiation Injuries / Q000150:complications*; D011878:Radiotherapy / Q000009:adverse effects*; D013131:Spine / Q000473:pathology / Q000528:radiation effects; D013904:Thoracic Vertebrae; D014062:Tongue Neoplasms / Q000473:pathology / Q000532:radiotherapy
chemical_list: D005938:Glucocorticoids; D008775:Methylprednisolone