Growth inhibition of Trichophyton species by Pseudomonas aeruginosa.
OBJECTIVE
To assess the ability of Pseudomonas aeruginosa to inhibit the growth of Trichophyton mentagrophytes (TM) and Trichophyton rubrum (TR).


METHODS
Pseudomonas aeruginosa, Escherichia coli, or Staphylococcus epidermidis were grown in co-culture with either TM or TR.


METHODS
An academic medical center.


METHODS
The total fungal units and hyphal-spore ratio were measured at days 1, 5, 10, and 15.


RESULTS
There was a 73% and 46% reduction of total fungal units and a final hyphal-spore ratio of 0.16 and 0.04, respectively, when TM and TR were co-cultured with P aeruginosa. The number of fungal units increased when TM and TR were cultured with E coli (28% and 42%, respectively), S epidermidis (13% and 18%, respectively), and control media (44% and 62%, respectively), and the hyphal-spore ratio increased to above 30 in the presence of S epidermidis, E coli, and control media.


CONCLUSIONS
Pseudomonas aeruginosa exhibits growth inhibitory properties against TM and TR.
Treat
James
J
Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
James
William D
WD
Nachamkin
Irving
I
Seykora
John T
JT
D018920:Coculture Techniques; D003196:Computer Graphics; D004926:Escherichia coli / Q000378:metabolism; D006090:Gram-Negative Bacteria / Q000378:metabolism*; D006131:Growth Inhibitors; D006801:Humans; D011550:Pseudomonas aeruginosa / Q000378:metabolism*; D013212:Staphylococcus epidermidis / Q000378:metabolism; D013997:Time Factors; D014249:Trichophyton / Q000145:classification / Q000254:growth & development* / Q000378:metabolism
D006131:Growth Inhibitors