title: Treatment of hereditary angioneurotic oedema (HANE) with tibolone.
abstract: OBJECTIVE
  Eight women, aged 25-58 years, with hereditary angioneurotic oedema (HANE) were treated with tibolone, a synthetic steroid exhibiting oestrogenic, androgenic and progestational activity.
  
  
  METHODS
  Pilot study.
  
  
  RESULTS
  Tibolone at a dose of 2.5-7.5 mg/day significantly reduced the number and severity of attacks and the number of ampoules of C1-esterase inhibitor (C1-INH) needed for symptomatic therapy. The efficacy of tibolone was comparable to that of danazol, while the androgenic side-effects were considerably reduced.
  
  
  CONCLUSIONS
  Tibolone may represent an alternative to danazol administration for the prophylaxis of HANE in women.
authors.affiliation: Clinical Division of Gynaecological Endocrinology and Reproductive Medicine, Medical University of Innsbruck, Austria. helmut.ott@uibk.ac.at
authors.forename: H W
authors.initials: HW
authors.lastname: Ott
authors.forename: V
authors.initials: V
authors.lastname: Mattle
authors.forename: D
authors.initials: D
authors.lastname: Hadziomerovic
authors.forename: P
authors.initials: P
authors.lastname: Licht
authors.forename: K
authors.initials: K
authors.lastname: Döinghaus
authors.forename: A
authors.initials: A
authors.lastname: Rubbert
authors.forename: K
authors.initials: K
authors.lastname: Manger
authors.forename: B
authors.initials: B
authors.lastname: Manger
authors.forename: J
authors.initials: J
authors.lastname: Kalden
authors.forename: L
authors.initials: L
authors.lastname: Wildt
mesh_terms: D000328:Adult; D000799:Angioedema / Q000188:drug therapy* / Q000235:genetics*; D003174:Complement C1 Inactivator Proteins / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008875:Middle Aged; D009652:Norpregnenes / Q000627:therapeutic use*; D010865:Pilot Projects; D016896:Treatment Outcome
chemical_list: D003174:Complement C1 Inactivator Proteins; D009652:Norpregnenes; C027385:tibolone