PTEN enters the nuclear age.
Regulation of the PTEN tumor suppressor protein is poorly understood. In this issue, Wang et al. (2007) and Trotman et al. (2007) describe how ubiquitination regulates PTEN stability and its nuclear localization. Additionally, Shen et al. (2007) report that a nuclear pool of PTEN helps to maintain chromosomal stability.
Baker
Suzanne J
SJ
Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. suzanne.baker@stjude.org
D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism*; D043171:Chromosomal Instability; D003593:Cytoplasm / Q000378:metabolism; D006801:Humans; D051059:PTEN Phosphohydrolase / Q000378:metabolism*; D011499:Protein Processing, Post-Translational; D025801:Ubiquitin / Q000378:metabolism
D025801:Ubiquitin; D051059:PTEN Phosphohydrolase