[Case of severe ulcerative colitis successfully treated with intravenous cyclosporine without high dose corticosteroid].
A 44-year-old women developed marked myopathy one year earlier, when she was treated with intravenous prednisolone for acute severe exacerbation of ulcerative colitis. When she was admitted to our hospital for another severe exacerbation, intravenous cyclosporine A was administered as monotherapy because she could not tolerate corticosteroid. The treatment was successful and she obtained complete remission. Cyclosporine A monotherapy is considered to be a valuable alternative to proctocolectomy for severe ulcerative colitis patients who cannot tolerate corticosteroid.
Kubota
Daisuke
D
Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Japan.
Kanai
Takanori
T
Yui
Fumiro
F
Matsumoto
Tomoko
T
Kawamura
Takahiro
T
Itsui
Yasuhiro
Y
Okada
Eriko
E
Chin
Seishin
S
Ooka
Shinya
S
Nagahori
Masakazu
M
Tsuchiya
Kiichiro
K
Araki
Akihiro
A
Sakamoto
Naoya
N
Miyata
Tatsuya
T
Watanabe
Mamoru
M
D000328:Adult; D003093:Colitis, Ulcerative / Q000188:drug therapy*; D016572:Cyclosporine / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage*; D007262:Infusions, Intravenous; D015122:Mercaptopurine / Q000008:administration & dosage; D011239:Prednisolone / Q000008:administration & dosage* / Q000009:adverse effects*; D016896:Treatment Outcome
D007166:Immunosuppressive Agents; D016572:Cyclosporine; D011239:Prednisolone; D015122:Mercaptopurine