Comment on "A common genetic variant is associated with adult and childhood obesity".
Herbert et al. (Reports, 14 April 2006, p. 279) reported an association between the INSIG2 gene variant rs7566605 and obesity in four sample populations, under a recessive model. We attempted to replicate this result in 10,265 Caucasian individuals, combining family-based, case-control, and general population studies, but found no support for a major role of this variant in obesity.
Dina
Christian
C
CNRS 8090-Institute of Biology, Pasteur Institute, Lille, France. dina@good.ibl.fr
Meyre
David
D
Samson
Chantal
C
Tichet
Jean
J
Marre
Michel
M
Jouret
Beatrice
B
Charles
Marie Aline
MA
Balkau
Beverley
B
Froguel
Philippe
P
D000328:Adult; D015992:Body Mass Index; D016022:Case-Control Studies; D002648:Child; D005190:Family; D005260:Female; D005602:France; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics*; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D009765:Obesity / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D044465:White People
C467727:INSIG2 protein, human; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins