Expression of Syk in invasive breast cancer: correlation to proliferation and invasiveness.
BACKGROUND
Spleen tyrosine kinase (Syk) kinase has recently been considered as a tumor suppressor gene in breast cancer.


METHODS
Syk expression in patients with invasive breast cancer was immunohistochemically assessed.


RESULTS
Decreased expression was found in 26% of the specimens examined. In cases with vascular invasion, expression of Syk was lost in the intravascular emboli. A significant relationship between increased proliferation levels (as estimated by the proliferative index, Ki67) and decreased Syk expression (p <0.05) was found.


CONCLUSIONS
Our data suggest that Syk protein expression inversely correlates with the proliferation and invasive capacity of breast cancer.
Repana
Katerina
K
Laboratory of Biochemistry, Department of Chemistry, Aristotle University of Thessaloniki, 54124, Thessaloniki, Greece.
Papazisis
Konstantinos
K
Foukas
Periklis
P
Valeri
Rozalia
R
Kortsaris
Alexandros
A
Deligiorgi
Eleni
E
Kyriakidis
Dimitrios
D
D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000201:enzymology* / Q000473:pathology; D018567:Breast Neoplasms, Male / Q000201:enzymology* / Q000473:pathology; D048708:Cell Growth Processes / Q000502:physiology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D047908:Intracellular Signaling Peptides and Proteins; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D011505:Protein-Tyrosine Kinases / Q000096:biosynthesis*; D023062:Receptors, Interleukin-8A / Q000096:biosynthesis; D023063:Receptors, Interleukin-8B / Q000096:biosynthesis; D000072377:Syk Kinase
D047908:Intracellular Signaling Peptides and Proteins; D023062:Receptors, Interleukin-8A; D023063:Receptors, Interleukin-8B; D011505:Protein-Tyrosine Kinases; C000606896:SYK protein, human; D000072377:Syk Kinase