title: TRPM8.
abstract: Originally cloned as a prostate-specific protein, TRPM8 is now best known as a cold- and menthol-activated channel implicated in thermosensation. In this chapter we provide a brief review of current knowledge concerning the biophysical properties, gating mechanisms, pharmacology and (patho)physiology of this TRP channel.
authors.affiliation: Laboratory of Physiology, KU Leuven, Campus Gasthuisberg O and N, 3000 Leuven, Belgium. Thomas.voets@med.kuleuven.be
authors.forename: T
authors.initials: T
authors.lastname: Voets
authors.forename: G
authors.initials: G
authors.lastname: Owsianik
authors.forename: B
authors.initials: B
authors.lastname: Nilius
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D015640:Ion Channel Gating / Q000187:drug effects / Q000502:physiology; D009369:Neoplasms / Q000235:genetics / Q000473:pathology; D050053:TRPM Cation Channels / Q000819:agonists / Q000037:antagonists & inhibitors / Q000235:genetics* / Q000502:physiology*; D013697:Thermosensing / Q000235:genetics / Q000502:physiology
chemical_list: D050053:TRPM Cation Channels; C425966:TRPM8 protein, human; C492297:TRPM8 protein, mouse; C498947:Trpm8 protein, rat; D002118:Calcium