[Concentration in plasma and excretion in milk of lactating cows after oral administration of tribromsalan, oxyclozanide and bromofenofos].
The fasciolicides tribromsalan (TBS), oxyclozanide (OCZ) and bromofenofos (BFF) were orally administered to three lactating cows. The concentrations of TBS, OCZ and the BFF metabolite dephosphate bromofenofos (DBFF) in plasma, and the excretion of these compounds in milk were determined by high-performance liquid chromatography. In plasma, the concentrations of TBS, OCZ and DBFF reached maximum at about 1.0 day and the compounds remained detectable until 5.7, 7.4 and 15.1 days after administration, respectively. The detection limits of these compounds in plasma were 10, 2 and 2 ppb, respectively. In milk, the concentrations of TBS, OCZ and DBFF reached maximum at about 24 hours and the compounds remained detectable until 30-47, 30-47 and 78-119 hours after administration, respectively. The detection limits of these compounds in milk were 5.1 and 1 ppb, respectively. The residence times of TBS and BFF were very close to the withdrawal times of the fasciolicides.
Fujinuma
Kenji
K
Tokyo Metropolitan Institute of Public Health, 3-24-1, Hyakunin-cho, Shinjuku-ku, Tokyo 169-0073, Japan.
Takeba
Kazue
K
Kamata
Kunihiro
K
D000284:Administration, Oral; D000818:Animals; D000980:Antiplatyhelmintic Agents / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D002417:Cattle; D002851:Chromatography, High Pressure Liquid; D004350:Drug Residues / Q000032:analysis* / Q000493:pharmacokinetics*; D005260:Female; D007774:Lactation / Q000378:metabolism*; D008892:Milk / Q000378:metabolism*; D010097:Oxyclozanide / Q000008:administration & dosage / Q000032:analysis* / Q000493:pharmacokinetics*; D011075:Polybrominated Biphenyls / Q000008:administration & dosage / Q000032:analysis* / Q000493:pharmacokinetics*; D012458:Salicylanilides / Q000008:administration & dosage / Q000032:analysis* / Q000493:pharmacokinetics*; D013997:Time Factors
D000980:Antiplatyhelmintic Agents; D011075:Polybrominated Biphenyls; D012458:Salicylanilides; D010097:Oxyclozanide; C004361:tribromsalan; C018474:bromophenophos