Mixed epithelial and stromal tumour of the kidney with luteinised ovarian stroma.
We report a case of a 9-cm mixed epithelial and stromal tumour of the kidney in an obese 70-year-old woman with diabetes. The ovarian-type stroma had a spindle cell component that was positive for progesterone receptors and had the hitherto unreported presence of abundant foci of luteinised stromal cells with characteristic immunohistochemical positivity to alpha-inhibin, calretinin, aromatase and gonadotropin-releasing hormone (GnRH) receptors. We conclude that the stromal component is identical to ovarian cortical stroma. We believe that ovarian-type stroma occurs in extragenital tumours as a result of an epithelial-stromal interaction in an environment of hormonal hyperstimulation.
Buritica
C
C
Department of Pathology, University Hospital, Granada, Spain.
Serrano
M
M
Zuluaga
A
A
Arrabal
M
M
Regauer
S
S
Nogales
F F
FF
D000368:Aged; D003924:Diabetes Mellitus, Type 2 / Q000150:complications; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000209:etiology / Q000473:pathology*; D018198:Mixed Tumor, Malignant / Q000209:etiology / Q000473:pathology*; D009375:Neoplasms, Glandular and Epithelial / Q000209:etiology / Q000473:pathology*; D009765:Obesity / Q000150:complications; D017154:Stromal Cells / Q000473:pathology