Chiral aggregates formed from methylated tetraenoic fatty acids: formation of both antipodes of chiral aggregates from a single enantiomer and time-dependent stereomutation.
Formation and behaviors of chiral aggregates of methylated tetraenoic fatty acids (TE-FAs) were reported. In the C-24 TE-FA series, the aggregate prepared by dispersing an ethanol stock solution of C-24 TE-FA 1b into sodium phosphate buffer gave a strong positive Cotton effect, whereas the aggregate prepared from a methanol stock solution gave a negative Cotton effect. In the C-20 TE-FA series, the aggregate prepared from an ethanol stock solution of C-20 TE-FA 2b exhibited time-dependent chirality inversion. [see text].
Ma
Jianguo
J
Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA.
Cheon
Hwan-Sung
HS
Kishi
Yoshito
Y
D002942:Circular Dichroism / Q000379:methods; D005231:Fatty Acids, Unsaturated / Q000737:chemistry*; D046911:Macromolecular Substances / Q000138:chemical synthesis / Q000737:chemistry; D015394:Molecular Structure; D012680:Sensitivity and Specificity; D013056:Spectrophotometry, Ultraviolet / Q000379:methods; D013237:Stereoisomerism; D013997:Time Factors
D005231:Fatty Acids, Unsaturated; D046911:Macromolecular Substances