title: Green tea [Camellia sinensis (L.) O. Kuntze] extract reverses the despair behaviour in reserpinised and diabetic mice.
abstract: Green tea (C. sinensis) extract (GTE) dose dependently produced reversal of despair in normal, reserpinised and diabetic mice, thereby demonstrating an antidepressant effect. Although the exact mechanism is yet to be explored, the possible inhibition of catechol-o-methyl transferase and monoamine oxidase enzymes may be responsible for antidepressant activity of GTE.
authors.affiliation: Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160 014, India.
authors.forename: Anjali
authors.initials: A
authors.lastname: Singal
authors.forename: Naveen
authors.initials: N
authors.lastname: Tirkey
authors.forename: Anjaneyulu
authors.initials: A
authors.lastname: Muragundla
authors.forename: Kanwaljit
authors.initials: K
authors.lastname: Chopra
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects; D028241:Camellia sinensis / Q000737:chemistry*; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000523:psychology*; D006185:Habituation, Psychophysiologic / Q000187:drug effects; D006380:Helplessness, Learned; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D008517:Phytotherapy / Q000379:methods; D010936:Plant Extracts / Q000494:pharmacology*; D012110:Reserpine / Q000494:pharmacology*; D013311:Streptozocin; D013550:Swimming
chemical_list: D000928:Antidepressive Agents; D010936:Plant Extracts; D013311:Streptozocin; D012110:Reserpine