Comment on "A common genetic variant is associated with adult and childhood obesity".
Herbert et al. (Reports, 14 April 2006, p. 279) found that the rs7566605 genetic variant, located upstream of the INSIG2 gene, was consistently associated with increased body mass index. However, we found no evidence of association between rs7566605 and body mass index in two large ethnically homogeneous population-based cohorts. On the contrary, an opposite tendency was observed.
Loos
Ruth J F
RJ
Medical Research Council Epidemiology Unit, Cambridge, UK. ruth.loos@mrc-epid.cam.ac.uk
Barroso
Inês
I
O'rahilly
Stephen
S
Wareham
Nicholas J
NJ
D000328:Adult; D000483:Alleles; D015992:Body Mass Index; D015331:Cohort Studies; D005260:Female; D005808:Genes, Recessive; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics*; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D009765:Obesity / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D044465:White People
C467727:INSIG2 protein, human; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins