Industrially feasible alternative approaches in the manufacture of solid dispersions: a technical report.
The purpose of this report was to compile relevant technical information on various alternative strategies that can be used as feasible approaches in the development of solid dispersions. The technologies discussed in the report are spray coating on sugar beads with a fluidized bed coating system, hot melt extrusion, direct capsule filling, electrostatic spinning, surface active carriers, and supercritical fluid technology. The focus is on basic principles, the equipment involved, and the relevant scale-up work. These technologies have been found to eliminate several drawbacks posed by the conventional methods of manufacturing of solid dispersions such as laborious preparation methods, reproducibility, scaling up of manufacturing processes, stability of drug, and vehicle.
Karanth
Hamsaraj
H
New Drug Delivery Systems Laboratory, Pharmacy Department, Donors Plaza, Opp University Main Office, M S University of Baroda, Vadodara-390 002, India.
Shenoy
Vikram Subraya
VS
Murthy
Rayasa Ramachandra
RR
D004337:Drug Carriers / Q000737:chemistry*; D004339:Drug Compounding / Q000295:instrumentation* / Q000379:methods* / Q000639:trends; D004345:Drug Industry / Q000295:instrumentation* / Q000379:methods* / Q000639:trends; D005240:Feasibility Studies; D004364:Pharmaceutical Preparations / Q000008:administration & dosage / Q000737:chemistry*; D011208:Powders; D012995:Solubility; D013678:Technology, Pharmaceutical / Q000295:instrumentation / Q000379:methods / Q000639:trends
D004337:Drug Carriers; D004364:Pharmaceutical Preparations; D011208:Powders