title: Insulinoma in a dog with pre-existing insulin-dependent diabetes mellitus.
abstract: A 10-year-old golden retriever with a 3-year history of insulin-dependent diabetes mellitus was presented with recurring episodes of hypoglycemia and seizures. A presumptive diagnosis of an insulinoma was made based on hypoglycemia with concurrent endogenous hyperinsulinemia and unremarkable radiographic and ultrasonographic images of the chest and abdomen. A beta cell carcinoma of the pancreas with metastasis to the liver and a mesenteric lymph node was confirmed by surgery and histopathology.
authors.affiliation: Department of Small Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon, Saskatchewan S7N 5B4 Canada.
authors.forename: Elizabeth R
authors.initials: ER
authors.lastname: Bryson
authors.forename: Elisabeth C R
authors.initials: EC
authors.lastname: Snead
authors.forename: Chantal
authors.initials: C
authors.lastname: McMillan
authors.forename: Lori
authors.initials: L
authors.lastname: MacDougall
authors.forename: Andrew L
authors.initials: AL
authors.lastname: Allen
mesh_terms: D000818:Animals; D000897:Anti-Ulcer Agents / Q000008:administration & dosage; D000906:Antibodies / Q000378:metabolism; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000662:veterinary*; D004283:Dog Diseases / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D004285:Dogs; D007003:Hypoglycemia / Q000209:etiology / Q000662:veterinary; D007004:Hypoglycemic Agents / Q000008:administration & dosage; D007328:Insulin / Q000008:administration & dosage / Q000032:analysis; D007340:Insulinoma / Q000556:secondary / Q000601:surgery / Q000662:veterinary*; D007813:Laparotomy / Q000662:veterinary; D008113:Liver Neoplasms / Q000556:secondary / Q000662:veterinary*; D008198:Lymph Nodes / Q000473:pathology / Q000601:surgery; D008207:Lymphatic Metastasis; D008297:Male; D008643:Mesentery; D010190:Pancreatic Neoplasms / Q000473:pathology / Q000601:surgery / Q000662:veterinary*; D011899:Ranitidine / Q000008:administration & dosage; D012640:Seizures / Q000209:etiology / Q000662:veterinary; D016896:Treatment Outcome
chemical_list: D000897:Anti-Ulcer Agents; D000906:Antibodies; D007004:Hypoglycemic Agents; D007328:Insulin; D011899:Ranitidine