title: [Tissue array analysis of the aberrant expression of HLA class I molecules in human non small cell lung cancer].
abstract: A clinical significance of the aberrant expression of HLA class I molecules including HLA class I and HLA-G was analyzed using tissue array analysis. Our institute has established a two millimeter spot sized tissue array set of 105 clinical cases of resected human non small cell lung cancer tissues. A loss of HLA class I was observed in the 58.3% of cancer tissues. The aberrant expression of HLA G was also observed in the 55.2% of cancer tissues. Statistically significant correlations were observed among HLA class I expression and tumor size, nodal involvement and pathological stage. Survival analyses were shown that the HLA class I loss was correlated to a recurrence free survival time. The HLA-G expression did not correlate with any clinico-pathological parameters. A loss of HLA class I was probably involved due to a cancer progression in human non-small cell lung cancer through the mechanism of immune escape from the host immune system.
authors.affiliation: Dept. of Surgery I, Fukushima Medical University.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Suzuki
authors.forename: Mitsunori
authors.initials: M
authors.lastname: Higuchi
authors.forename: Takeo
authors.initials: T
authors.lastname: Hasegawa
authors.forename: Atsushi
authors.initials: A
authors.lastname: Yonechi
authors.forename: Jun
authors.initials: J
authors.lastname: Ohsugi
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Yamada
authors.forename: Mika
authors.initials: M
authors.lastname: Hoshino
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Shio
authors.forename: Koichi
authors.initials: K
authors.lastname: Fujiu
authors.forename: Mitsukazu
authors.initials: M
authors.lastname: Gotoh
mesh_terms: D000368:Aged; D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D018572:Disease-Free Survival; D005260:Female; D015870:Gene Expression; D005805:Genes, MHC Class I / Q000235:genetics*; D006680:HLA Antigens / Q000235:genetics*; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D008297:Male; D046888:Tissue Array Analysis
chemical_list: D006680:HLA Antigens; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I