title: Spontaneous tumor lysis syndrome in acute myeloid leukemia: two cases and a review of the literature.
abstract: Spontaneous tumor lysis syndrome (TLS) is a constellation of electrolyte abnormalities and acute renal failure, which occurs in the setting of rapid cell turnover prior to the administration of cytotoxic chemotherapy. While spontaneous TLS is well described in patients with Burkitt's lymphoma, it is thought to occur less commonly in other hematologic malignancies. We present two cases of spontaneous TLS in patients with newly diagnosed acute myeloid leukemia (AML) followed by a review of the literature in this field.
authors.affiliation: Department of Internal Medicine, Beth Israel Deaconess Medical Center, Harvard University, Boston, Massachusetts, USA.
authors.forename: Brett
authors.initials: B
authors.lastname: Riccio
authors.forename: Anthony
authors.initials: A
authors.lastname: Mato
authors.forename: Erin M
authors.initials: EM
authors.lastname: Olson
authors.forename: Jeffrey S
authors.initials: JS
authors.lastname: Berns
authors.forename: Selina
authors.initials: S
authors.lastname: Luger
mesh_terms: D000368:Aged; D001806:Blood Urea Nitrogen; D002051:Burkitt Lymphoma / Q000150:complications; D003404:Creatinine / Q000097:blood; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000150:complications*; D008297:Male; D008875:Middle Aged; D015275:Tumor Lysis Syndrome / Q000145:classification / Q000150:complications*
chemical_list: D003404:Creatinine