title: Expression of SpanX mRNA in testicular germ cell tumors.
abstract: The function of SpanX proteins is unknown, evidence is accumulating to suggest their involvement in tumorigenesis. A locus in Xq27, where the SpanX gene family is located, has been associated with testicular germ cell tumor (TGCT) onset. Therefore, we evaluated the presence of SpanX mRNA in six TGCT cases by RT-PCR. The results showed that SpanX mRNA is present in TGCT, confirming transcriptional activity of these genes in such tumors.
authors.affiliation: Section of Endocrinology, Andrology and Internal Medicine, Department of Biomedical Sciences, University of Catania, Catania, Italy. msalemi@oasi.en.it
authors.forename: Michele
authors.initials: M
authors.lastname: Salemi
authors.forename: Aldo E
authors.initials: AE
authors.lastname: Calogero
authors.forename: Paolo
authors.initials: P
authors.lastname: Bosco
authors.forename: Roberto
authors.initials: R
authors.lastname: Castiglione
authors.forename: Sandro
authors.initials: S
authors.lastname: La Vignera
authors.forename: Eugenia
authors.initials: E
authors.lastname: Borgione
authors.forename: Giancarlo
authors.initials: G
authors.lastname: Rappazzo
authors.forename: Enzo
authors.initials: E
authors.lastname: Vicari
mesh_terms: D001483:Base Sequence; D041321:Chromosomes, Human, X / Q000235:genetics; D018076:DNA, Complementary / Q000235:genetics; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D009373:Neoplasms, Germ Cell and Embryonal / Q000235:genetics*; D009687:Nuclear Proteins / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D016415:Sequence Alignment; D013736:Testicular Neoplasms / Q000235:genetics*; D014158:Transcription, Genetic
chemical_list: D018076:DNA, Complementary; D009687:Nuclear Proteins; D012333:RNA, Messenger; C414403:SPANXA1 protein, human