title: Antiplasmodial activity of Setaria megaphylla.
abstract: The antimalarial activity of an ethanol leaf extract of Setaria megaphylla was studied in vivo in mice infected with Plasmodium berghei berghei during early and established infections. Setaria megaphylla (100-300 mg/kg/day) exhibited a significant (p < 0.05) blood schizonticidal activity in 4-day early infection and in established infection with a significant (p < 0.05) mean survival time comparable to that of the standard drug, chloroquine, 5 mg/kg/day. The leaf extract possesses a promising antiplasmodial activity in vivo which can be exploited in malaria therapy.
authors.affiliation: Pharmacology and Toxicology Department, Faculty of Pharmacy, University of Uyo, Uyo, Nigeria. judeefiom@yahoo.com
authors.forename: Jude E
authors.initials: JE
authors.lastname: Okokon
authors.forename: Peace M E
authors.initials: PM
authors.lastname: Ubulom
authors.forename: Aniekan E
authors.initials: AE
authors.lastname: Udokpoh
mesh_terms: D000818:Animals; D008288:Malaria / Q000188:drug therapy*; D051379:Mice; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology* / Q000627:therapeutic use; D018515:Plant Leaves; D010962:Plasmodium berghei / Q000187:drug effects*; D032983:Setaria Plant
chemical_list: D010936:Plant Extracts