title: The effect of prior radiation therapy for treatment of nasopharyngeal cancer on wound healing following extractions: incidence of complications and risk factors.
abstract: This is a prospective study of wound healing after extractions in patients who had radiation therapy for nasopharyngeal cancer. From 40 patients who fulfilled all the study criteria were extracted a total of 155 teeth. The demographic data were analysed, checking for factors that might affect the healing process after extraction. Wound healing was divided into three groups: normal wound healing, delayed healing and osteoradionecrosis. Logistic regression was used to analyse possible relationships. There was a low complication rate: 5.8% and 1.9% of extractions showed delayed healing and osteoradionecrosis, respectively. The age of the patient at time of extraction was the only significant factor that influenced the occurrence of delayed healing. It was observed that localized radiation absorption was considerably different from the total radiation dose. In conclusion, postradiation extractions have a low risk of complications and the results point to age as a factor that may influence wound healing.
authors.affiliation: Department of Oral & Maxillofacial Surgery, National Dental Centre, Singapore. kokwenglye@yahoo.com
authors.forename: K W
authors.initials: KW
authors.lastname: Lye
authors.forename: J
authors.initials: J
authors.lastname: Wee
authors.forename: F
authors.initials: F
authors.lastname: Gao
authors.forename: P S H
authors.initials: PS
authors.lastname: Neo
authors.forename: Y L
authors.initials: YL
authors.lastname: Soong
authors.forename: C Y
authors.initials: CY
authors.lastname: Poon
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D003724:Dental Arch / Q000528:radiation effects; D004848:Epithelium / Q000528:radiation effects; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000532:radiotherapy*; D010025:Osteoradionecrosis / Q000209:etiology; D011446:Prospective Studies; D011878:Radiotherapy / Q000009:adverse effects; D011879:Radiotherapy Dosage; D012307:Risk Factors; D013997:Time Factors; D014070:Tooth / Q000528:radiation effects; D014081:Tooth Extraction; D020390:Tooth Socket / Q000528:radiation effects*; D016896:Treatment Outcome; D014945:Wound Healing / Q000528:radiation effects