title: Clinicopathological differences between hepatitis B viral genotype B- and C-related resectable hepatocellular carcinoma.
abstract: Clinical and pathogenic differences exist between hepatitis B viral (HBV) genotypes B and C, and genotype C has a higher risk of hepatocellular carcinoma (HCC) development than genotype B. The aim of this study was to investigate whether HBV genotypes B and C influence the clinicopathological features of patients with resectable HCC. Stored serum samples from 193 patients with resectable HBV-related HCC were tested for HBV genotypes by a molecular method. Of 193 patients undergoing resection of HCC, 107 (55%) and 86 (45%) were infected with genotypes B and C, respectively. Compared with genotype C patients, genotype B patients were less likely to be associated with liver cirrhosis (33%vs 51%, P = 0.01). Pathologically, genotype B patients had a higher rate of solitary tumour (94%vs 86%, P = 0.048) and more satellite nodules (22%vs 12%, P = 0.05) than genotype C patients. Our results indicate that genotype B-related HCC is less associated with liver cirrhosis and has a higher frequency of solitary tumour as well as more satellite nodules than genotype C-related HCC. These characteristics may contribute to the recurrence patterns and prognosis of HBV-related HCC in patients with genotype B or C infection.
authors.affiliation: Department of Gastroenterology, Ren-Ai Branch, Taipei City Hospital, Taipei, Taiwan.
authors.forename: C-L
authors.initials: CL
authors.lastname: Lin
authors.forename: J-D
authors.initials: JD
authors.lastname: Chen
authors.forename: C-J
authors.initials: CJ
authors.lastname: Liu
authors.forename: P-H
authors.initials: PH
authors.lastname: Lee
authors.forename: P-J
authors.initials: PJ
authors.lastname: Chen
authors.forename: M-Y
authors.initials: MY
authors.lastname: Lai
authors.forename: J-H
authors.initials: JH
authors.lastname: Kao
authors.forename: D-S
authors.initials: DS
authors.lastname: Chen
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D001663:Bilirubin / Q000097:blood; D006528:Carcinoma, Hepatocellular / Q000097:blood / Q000473:pathology / Q000821:virology*; D004279:DNA, Viral / Q000737:chemistry / Q000235:genetics; D005260:Female; D005838:Genotype; D006515:Hepatitis B virus / Q000235:genetics*; D019694:Hepatitis B, Chronic / Q000097:blood / Q000473:pathology / Q000821:virology*; D006801:Humans; D008113:Liver Neoplasms / Q000097:blood / Q000473:pathology / Q000821:virology*; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011517:Prothrombin Time; D012189:Retrospective Studies; D012709:Serum Albumin / Q000378:metabolism; D000509:alpha-Fetoproteins / Q000378:metabolism
chemical_list: D004279:DNA, Viral; D012709:Serum Albumin; D000509:alpha-Fetoproteins; D000410:Alanine Transaminase; D001663:Bilirubin