title: Use of oxidized cellulose for corporal body grafting and suture-less correction of severe penile chordee: an experimental study in rabbits.
abstract: OBJECTIVE
  To evaluate the efficacy of oxidized cellulose, Surgicel(TM) (Johnson & Johnson Medical, New Brunswick, NJ, USA) for patching defects in the tunica albuginea in a rabbit model, with a future application to correct chordee.
  
  
  METHODS
  The study comprised nine New Zealand white male rabbits; a rectangular 15 x 5-mm defect was created in the ventral tunica albuginea that was covered by Surgicel. The skin was closed with no catheters left in situ after the procedure. The rabbits were killed in groups of three at 2, 6 and 12 weeks after surgery. The evaluation included cavernosography and histopathological examination of sections of the penis stained with haematoxylin and eosin, and Masson's trichrome.
  
  
  RESULTS
  No deaths were caused by the procedure, and none of the rabbits developed bleeding or haematoma after surgery. Cavernosography at 2 weeks showed contrast medium leaking from the site of the Surgicel, but at 6 and 12 weeks all rabbits had a straight erection with patent corpora and no evidence of narrowing or venous leak. Histopathological evaluation revealed evidence of the remnants of Surgicel surrounded by acute inflammatory cell infiltrate with early neovascularization at 2 weeks. At 6 and 12 weeks, there was complete normal regeneration of the tunica albuginea with no foreign-body reaction.
  
  
  CONCLUSIONS
  In this pilot study, Surgicel had a clear haemostatic effect when covering a defect in the tunica albuginea. Moreover, normal tunica albuginea regenerated by 6 weeks and was maintained at 12 weeks. These results suggest that Surgicel might be considered a safe and effective grafting material for tunica albuginea substitution, including the surgical management of penile chordee.
authors.affiliation: The Urology & Nephrology Centre, Mansoura University, Mansoura, Egypt. a_assmy@yahoo.com
authors.forename: Ahmed
authors.initials: A
authors.lastname: El-Assmy
authors.forename: Waleed
authors.initials: W
authors.lastname: Eassa
authors.forename: Mohamed Abd
authors.initials: MA
authors.lastname: El-Hamid
authors.forename: Eman M
authors.initials: EM
authors.lastname: Nour
authors.forename: Ashraf T
authors.initials: AT
authors.lastname: Hafez
mesh_terms: D000818:Animals; D002483:Cellulose, Oxidized / Q000627:therapeutic use*; D006490:Hemostatics / Q000627:therapeutic use*; D008297:Male; D023421:Models, Animal; D010409:Penile Diseases / Q000601:surgery*; D010410:Penile Erection; D010413:Penis / Q000601:surgery*; D010865:Pilot Projects; D011817:Rabbits; D016896:Treatment Outcome; D014945:Wound Healing
chemical_list: D002483:Cellulose, Oxidized; D006490:Hemostatics; C013695:Surgicel