title: Glaucoma detection with matrix and standard achromatic perimetry.
abstract: BACKGROUND
  Matrix perimetry is a new iteration of frequency-doubling technology (FDT) which uses a smaller target size in the standard achromatic perimetry presentation pattern.
  
  
  OBJECTIVE
  To compare the performance of matrix and Swedish interactive thresholding algorithm (SITA) perimetry in detecting glaucoma diagnosed by structural assessment.
  
  
  METHODS
  Prospective cross-sectional study.
  
  
  METHODS
  76 eyes from 15 healthy subjects and 61 consecutive glaucoma suspects and patients with glaucoma were included. All patients underwent optic nerve head (ONH) photography, SITA and matrix perimetries, and optical coherence tomography (OCT) within a 6-month period. Glaucoma diagnosis was established by either glaucomatous optic neuropathy or OCT by assessing retinal nerve fibre layer (RNFL) thickness. Mean deviation (MD), pattern standard deviation (PSD), glaucoma hemifield test and cluster of abnormal testing locations were recorded from matrix and SITA perimetries.
  
  
  RESULTS
  Similar correlations were observed with matrix and SITA perimetry MD and PSD with either cup-to-disc ratio or OCT mean RNFL. The area under the receiver operating characteristic (AROC) curves of MD and PSD for discriminating between healthy and glaucomatous eyes ranged from 0.69 to 0.81 for matrix perimetry and from 0.75 to 0.77 for SITA perimetry. There were no significant differences among any corresponding matrix and SITA perimetry AROCs.
  
  
  CONCLUSIONS
  Matrix and SITA perimetries had similar capabilities for distinguishing between healthy and glaucomatous eyes regardless of whether the diagnosis was established by ONH or OCT-RNFL assessment.
authors.affiliation: Department of Ophthalmology, UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, University of Pittsburgh School of Medicine,Pittsburgh, Pennsylvania 15213, USA.
authors.forename: Zvia
authors.initials: Z
authors.lastname: Burgansky-Eliash
authors.forename: Gadi
authors.initials: G
authors.lastname: Wollstein
authors.forename: Avni
authors.initials: A
authors.lastname: Patel
authors.forename: Richard A
authors.initials: RA
authors.lastname: Bilonick
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ishikawa
authors.forename: Larry
authors.initials: L
authors.lastname: Kagemann
authors.forename: William D
authors.initials: WD
authors.lastname: Dilworth
authors.forename: Joel S
authors.initials: JS
authors.lastname: Schuman
mesh_terms: D000328:Adult; D000368:Aged; D000465:Algorithms; D004812:Epidemiologic Methods; D005901:Glaucoma / Q000175:diagnosis*; D006801:Humans; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology; D009898:Optic Disk / Q000473:pathology; D012165:Retinal Ganglion Cells / Q000473:pathology; D041623:Tomography, Optical Coherence; D058609:Visual Field Tests / Q000379:methods*; D014794:Visual Fields