Defining correlates of T cell protection against infection.
It has been known for a long time that memory CD8+ T cells are the main players in conferring long-lasting and effective protection against infection with intracellular pathogens. The generation of instantly protective memory cells, so-called effector memory T cells, represents the basic principle of T cell-based vaccination strategies. Therefore, the understanding of the exact mechanisms required for in vivo generation of distinct CD8+ memory T cell subtypes will become the crucial rationale for enhancing the efficiency and quality of vaccine-induced protective immunity.
Stemberger
Christian
C
Institute for Medical Microbiology, Immunology and Hygiene, Technical University Munich, Munich, Germany.
Huster
Katharina M
KM
Busch
Dirk H
DH
D000818:Animals; D001424:Bacterial Infections / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000166:cytology / Q000276:immunology*; D006801:Humans; D007156:Immunologic Memory / Q000276:immunology; D008954:Models, Biological; D016176:T-Lymphocyte Subsets / Q000166:cytology / Q000276:immunology; D014777:Virus Diseases / Q000276:immunology