title: Infarct size assessment in mice.
abstract: Genetically modified mice are used extensively in models of ischemia reperfusion (I/R) and nonreperfused myocardial infarction (MI) to gain insights into pathways involved in these pathologies. Echocardiography is an ideal noninvasive tool to serially monitor the cardiac murine phenotype. The present review details the surgical aspects of I/R and MI models and the measurement of MI size by pathology techniques and the input of echocardiographic techniques including the extent of wall motion abnormality and of perfusion defects using myocardial contrast echocardiography in the assessment of murine area at risk and MI size.
authors.affiliation: Cardiac Ultrasound Laboratory, Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA. marielle@crosbie.com
authors.forename: Marielle
authors.initials: M
authors.lastname: Scherrer-Crosbie
authors.forename: Ana Clara T
authors.initials: AC
authors.lastname: Rodrigues
authors.forename: Ryuji
authors.initials: R
authors.lastname: Hataishi
authors.forename: Michael H
authors.initials: MH
authors.lastname: Picard
mesh_terms: D000818:Animals; D030801:Animals, Genetically Modified; D003287:Contrast Media; D003326:Coronary Circulation; D051379:Mice; D023421:Models, Animal; D009203:Myocardial Infarction / Q000000981:diagnostic imaging* / Q000473:pathology*; D015425:Myocardial Reperfusion; D014463:Ultrasonography
chemical_list: D003287:Contrast Media