Acute myeloid leukemia (AML-M2) with t(5;11)(q35;q13) and normal expression of cyclin D1.
We report a case of acute myeloid leukemia (AML) subtype M2, with t(5;11)(q35;q13), in a 30-year-old man. Conventional cytogenetic, spectral karyotyping, and fluorescence in situ hybridization (FISH) studies on bone marrow sample obtained at diagnosis revealed an abnormal karyotype in all cells examined. FISH analysis demonstrated absence of translocations in the region of the cyclin D1 gene and real-time quantitative reverse transcriptase-polymerase chain reaction revealed normal expression of this gene. Similar to the 11q23 region, 11q13 changes can be found in both myeloid and lymphoid neoplasias with different chromosomes serving as donors in translocations.
de Oliveira
Fábio Morato
FM
Departamento de Genética, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Av. Bandeirantes, 3900, 14049-900 Ribeirão Preto, SP, Brazil.
Tone
Luiz Gonzaga
LG
Simões
Belinda Pinto
BP
Falcão
Roberto Passetto
RP
Brassesco
María Sol
MS
Sakamoto-Hojo
Elza Tiemi
ET
dos Santos
Guilherme Augusto Silva
GA
Marinato
André Fiorin
AF
Jácomo
Rafael Henriques
RH
Rego
Eduardo Magalhães
EM
D000328:Adult; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics*; D002895:Chromosomes, Human, Pair 5 / Q000235:genetics*; D019938:Cyclin D1 / Q000096:biosynthesis* / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics* / Q000378:metabolism; D015479:Leukemia, Myelomonocytic, Acute; D008297:Male; D014178:Translocation, Genetic
D019938:Cyclin D1