Effect of royal jelly on bisphenol A-induced proliferation of human breast cancer cells.
Royal jelly is known as a functional food containing many useful minerals. In this study, we found an anti-environmental estrogen activity of royal jelly. Bisphenol A (BPA) is an environmental estrogen that stimulates proliferation of human breast cancer MCF-7 cells. Royal jelly inhibited the growth-promoting effect of BPA on MCF-7 cells, even though it did not affect the proliferation of cells in the absence of BPA. In addition, this inhibiting effect of royal jelly was heat-stable.
Nakaya
Mako
M
Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Japan. makorenu@agr.kyushu-u.ac.jp
Onda
Hiroyuki
H
Sasaki
Kyoko
K
Yukiyoshi
Akiko
A
Tachibana
Hirofumi
H
Yamada
Koji
K
D001559:Benzhydryl Compounds; D001943:Breast Neoplasms / Q000473:pathology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D005227:Fatty Acids / Q000494:pharmacology*; D006358:Hot Temperature; D006801:Humans; D010636:Phenols / Q000494:pharmacology*; D000099219:Royal Jelly; D000098826:Bisphenol A Compounds
D001559:Benzhydryl Compounds; D005227:Fatty Acids; D010636:Phenols; D000099219:Royal Jelly; C006780:bisphenol A; D000098826:Bisphenol A Compounds