[The significance of troponin T in hemodialysis patients].
BACKGROUND
Troponin T and I are located in the myocardium. Monitoring blood Troponin levels is advantageous in evaluating unstable angina over measuring CPK-MB, previously serving as a "golden standard" for urgent evaluation of myocardial infarct.


OBJECTIVE
To measure blood troponin T levels in hemodialysis patients without severe cardiovascular events, following its distribution according to various risk factors.


METHODS
Sera were collected from 68 hemodialysis (HD) patients before starting dialysis sessions and compared to 10 age- and gender-matched healthy volunteers (NC). Troponin T levels were measured using Troponin T STAT Elecsys-Roche kits.


RESULTS
Blood Troponin T levels were significantly higher in HD patients compared to NC (0.126 +/- 0.016 vs. 0.005 +/- 0 ng/dL, respectively; P=0.026). HD patients with ischemic heart disease (IHD) showed significantly higher levels of Troponin T, compared to HD patients without IHD (0.17+/-0.036 vs. 0.081 +/- 0.015 ng/dL, respectively; P=0.012). Diabetic (DM) HD patients showed higher levels of Troponin T, compared to non-DM HD patients (0.168+/-0.034 vs. 0.068+/-0.012 ng/dL, respectively; P= 0.002).


CONCLUSIONS
Troponin T may efficiently serve as a diagnostic, monitoring and prognostic parameter in HD patients.
Farah
Raymond
R
Department of Internal Medicine F, Western Galilee Hospital, Nahariya, Israel. raymond.farah@naharia.health.gov.il
Hahiashvilli
Avtandil
A
Shurtz-Swirski
Revital
R
Kristal
Batya
B
D015415:Biomarkers / Q000097:blood; D003928:Diabetic Nephropathies / Q000097:blood / Q000628:therapy; D006801:Humans; D008991:Monitoring, Physiologic; D012016:Reference Values; D006435:Renal Dialysis; D020107:Troponin T / Q000097:blood*
D015415:Biomarkers; D020107:Troponin T