title: Bioassay-guided isolation of antifungal alkaloids from Melochia odorata.
abstract: An alkaloidal extract of the leaves of Melochia odorata exhibited antifungal activity against Candida albicans, Cryptococcus neoformans and Saccharomyces cerevisiae using a TLC bioautographic method. Bioassay-guided fractionation of this extract using separation by normal and reverse high-performance liquid chromatography (HPLC) resulted in the isolation of two active compounds identified as frangulanine, a cyclic peptide alkaloid, and waltherione-A, a quinolinone alkaloid.
authors.affiliation: Laboratoire de Pharmacognosie UMR 8076 CNRS, Faculté de Pharmacie, Université Paris-Sud, rue J.B. Clément, 92296 Châtenay-Malabry cedex, France.
authors.forename: Aurélie
authors.initials: A
authors.lastname: Emile
authors.forename: Jean
authors.initials: J
authors.lastname: Waikedre
authors.forename: Christine
authors.initials: C
authors.lastname: Herrenknecht
authors.forename: Christophe
authors.initials: C
authors.lastname: Fourneau
authors.forename: Jean-Charles
authors.initials: JC
authors.lastname: Gantier
authors.forename: Edouard
authors.initials: E
authors.lastname: Hnawia
authors.forename: Pierre
authors.initials: P
authors.lastname: Cabalion
authors.forename: Reynald
authors.initials: R
authors.lastname: Hocquemiller
authors.forename: Alain
authors.initials: A
authors.lastname: Fournet
mesh_terms: D000470:Alkaloids / Q000302:isolation & purification* / Q000494:pharmacology; D000935:Antifungal Agents / Q000302:isolation & purification* / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects; D003455:Cryptococcus neoformans / Q000187:drug effects; D019660:Malvaceae / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D018515:Plant Leaves / Q000737:chemistry; D012441:Saccharomyces cerevisiae / Q000187:drug effects
chemical_list: D000470:Alkaloids; D000935:Antifungal Agents