title: [A case of stage IV gastric cancer treated sequentially for over two years by TS-1, paclitaxel, and CPT-11].
abstract: We report a patient with advanced stage IV gastric cancer treated by chemotherapy for over two years. The patient was a 69-year-old man with paraaortic lymph node metastasis of gastric cancer. He underwent a distal gastrectomy in non-curative resection. After surgery, chemotherapy with TS-1 (100 mg/body/day) was performed. At 7 months after surgery, progression of lymph node metastasis in porta hepatis was recognized, and paclitaxel was administered at a weekly dose of 80 mg/m(2) for 3 weeks followed by one week rest. He remained stable for 12 months under paclitaxel treatment. At 26 months after surgery, progression of lymph node metastasis in porta hepatis was recognized again, and CPT-11 was administered at a bi-weekly dose of 80 mg/m(2). Although the patient died two years seven months after surgery, the chemotherapy with sequential administration of TS-1, paclitaxel and CPT-11 was thought to be effective for advanced gastric cancer.
authors.affiliation: Dept. of Surgery, Osaka Kosei-Nenkin Hospital.
authors.forename: Yukio
authors.initials: Y
authors.lastname: Nakamura
authors.forename: Takeyoshi
authors.initials: T
authors.lastname: Yumiba
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Yamasaki
authors.forename: Takuya
authors.initials: T
authors.lastname: Momiyama
authors.forename: Akira
authors.initials: A
authors.lastname: Ito
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Akamaru
authors.forename: Naoko
authors.initials: N
authors.lastname: Ohse
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Yamamoto
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Kasugai
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000601:surgery; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002166:Camptothecin / Q000008:administration & dosage / Q000031:analogs & derivatives; D003131:Combined Modality Therapy; D004334:Drug Administration Schedule; D004338:Drug Combinations; D005743:Gastrectomy; D006801:Humans; D000077146:Irinotecan; D008297:Male; D010094:Oxonic Acid / Q000008:administration & dosage; D017239:Paclitaxel / Q000008:administration & dosage; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000601:surgery; D017741:Survivors; D005641:Tegafur / Q000008:administration & dosage
chemical_list: D004338:Drug Combinations; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid; D000077146:Irinotecan; D017239:Paclitaxel; D002166:Camptothecin