Effect of ACP1*C on early life viability.
Associations with past malarial morbidity, season of conception, and common diseases such as obesity, type 2 diabetes, and allergy argue against neutrality of the ACP1 genetic polymorphism. Comparison of ACP1 distribution in mothers and their newborns and analysis of the joint wife-husband ACP1 phenotype distribution in couples with repeated spontaneous abortion suggest a negative effect of the ACP1*C allele on early life viability. Analysis of the polymorphism of the ACP1 gene suggests that, unlike the ACP1*A and ACP1*B alleles, the ACP1*C allele is independent of sequences in the 5' flanking region, resulting in an inverted F/S isoform ratio.
Gloria-Bottini
F
F
Division of Biopathology of Human Populations and Environmental Pathology, Department of Biopathology and Imaging Diagnostics, University of Rome Tor Vergata, Rome, Italy.
Bottini
N
N
Bottini
E
E
D000022:Abortion, Spontaneous / Q000235:genetics; D000483:Alleles; D005260:Female; D005838:Genotype; D006801:Humans; D007231:Infant, Newborn; D007558:Italy; D008297:Male; D010641:Phenotype; D011110:Polymorphism, Genetic / Q000235:genetics*; D011159:Population Surveillance / Q000379:methods*; D011247:Pregnancy; D017027:Protein Tyrosine Phosphatases / Q000145:classification / Q000235:genetics*; D011518:Proto-Oncogene Proteins / Q000145:classification / Q000235:genetics*
D011518:Proto-Oncogene Proteins; C490429:ACP1 protein, human; D017027:Protein Tyrosine Phosphatases