Regulation of calcium signalling by adenine-based second messengers.
cADPR [cyclic ADPR (ADP-ribose)], NAADP (nicotinic acid-adenine dinucleotide phosphate) and ADPR belong to the family of adenine-containing second messengers. They are metabolically related and are all involved in the regulation of cellular Ca(2+) homoeostasis. Activation of specific plasma membrane receptors is connected to cADPR formation in many cell types and tissues. In contrast receptor-mediated formation of NAADP and ADPR has been shown only in a few selected cellular systems. The intracellular Ca(2+) channel triggered by cADPR is the RyR (ryanodine receptor); in the case of NAADP, both activation of RyR and a novel Ca(2+) channel have been proposed. In contrast, ADPR opens the non-specific cation channel TRPM2 [TRP (transient receptor potential) melastatin 2] that belongs to the TRP family of ion channels.
Fliegert
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The Calcium Signalling Group, Institute of Biochemistry and Molecular Biology I: Cellular Signal Transduction, Centre of Experimental Medicine, University Medical Centre Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany.
Gasser
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A
Guse
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AH
D000225:Adenine / Q000378:metabolism*; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D020013:Calcium Signaling; D036563:Cyclic ADP-Ribose / Q000737:chemistry; D006801:Humans; D008954:Models, Biological; D008956:Models, Chemical; D009249:NADP / Q000031:analogs & derivatives / Q000737:chemistry; D018048:Receptors, Purinergic P2 / Q000378:metabolism; D015290:Second Messenger Systems; D015398:Signal Transduction; D050053:TRPM Cation Channels / Q000378:metabolism
D018048:Receptors, Purinergic P2; D050053:TRPM Cation Channels; C121934:TRPM2 protein, human; D036563:Cyclic ADP-Ribose; D009249:NADP; C024376:NAADP; D000225:Adenine; D002118:Calcium