Efficient synthesis of phenanthridinone derivatives via a palladium-catalyzed coupling process.
A palladium-mediated domino reaction was developed to conveniently synthesize phenanthridinone derivatives. Phosphine ligand 1 strongly promotes the domino process, which includes aryl-aryl coupling and C-N bond formations concomitant with a deamidation reaction. The versatility and applicability to a broad range of substrates make this reaction useful for the development of bioactive derivatives. [reaction: see text].
Furuta
Takumi
T
School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan. furuta@u-shizuoka-ken.ac.jp
Kitamura
Yuki
Y
Hashimoto
Ayano
A
Fujii
Satoshi
S
Tanaka
Kiyoshi
K
Kan
Toshiyuki
T
D000085:Acetates / Q000737:chemistry; D002384:Catalysis; D008024:Ligands; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D010616:Phenanthrenes / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
D000085:Acetates; D008024:Ligands; D010616:Phenanthrenes; D010165:Palladium