Value of wireless capsule endoscopy in patients with indeterminate colitis (inflammatory bowel disease type unclassified).
BACKGROUND
Wireless capsule endoscopy (WCE) can identify small bowel mucosal lesions not seen with other imaging modalities. This technique can therefore play an important diagnostic role in the evaluation of patients with inflammatory bowel disease type unclassified (IBDU). We report on a multicentric study whose objective was to evaluate the value of WCE to increase diagnostic accuracy in categorizing IBDU.


METHODS
Thirty patients with IBDU and negative serology were included. WCE was performed with a standard Pillcam capsule. Outcome measures were classified as suggestive of Crohn's disease (CD) when -3 ulcerations were present.


RESULTS
WCE displayed endoscopic features suggestive for CD in 5 patients. In 6 other patients, WCE was negative, but repeated ileocolonoscopy with biopsies performed during follow-up evaluation revealed CD in 5 and ulcerative colitis (UC) in 1 patient. UC was found in a seventh case at colectomy performed just after WCE. Eighteen patients remained with a diagnosis of IBDU 16 months on average after WCE.


CONCLUSIONS
WCE is a potentially clinically useful technique for categorizing a subgroup of patients with IBDU, although negative WCE does not exclude further diagnosis of CD. Patients with negative WCE who remain IBDU at follow-up evaluation may belong to an original subgroup of IBD.
Maunoury
Vincent
V
Gastroenterology Department, University Hospital, Lille, France. vmaunoury@chru-lille.fr
Savoye
Guillaume
G
Bourreille
Arnaud
A
Bouhnik
Yoram
Y
Jarry
Marine
M
Sacher-Huvelin
Sylvie
S
Ben Soussan
Emmanuel
E
Lerebours
Eric
E
Galmiche
Jean-Paul
JP
Colombel
Jean-Frederic
JF
D000293:Adolescent; D000328:Adult; D053704:Capsule Endoscopy; D003092:Colitis / Q000175:diagnosis*; D003424:Crohn Disease / Q000175:diagnosis; D016099:Endoscopy, Gastrointestinal; D005260:Female; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000175:diagnosis*; D007421:Intestine, Small / Q000473:pathology*; D008297:Male; D008875:Middle Aged