Comment on "A common genetic variant is associated with adult and childhood obesity".
Contrary to the findings of Herbert et al. (Reports, 14 April 2006, p. 279), homozygous carriers of the C allele of the rs7566605 variant near the INSIG2 gene did not exhibit a significantly increased risk for obesity in a large population-based cross-sectional German study. A subgroup analysis, however, revealed that this allele significantly increased the risk for obesity in already overweight individuals.
Rosskopf
Dieter
D
Institute of Pharmacology, Ernst Moritz Arndt University of Greifswald, Germany. dieter.rosskopf@uni-greifswald.de
Bornhorst
Alexa
A
Rimmbach
Christian
C
Schwahn
Christian
C
Kayser
Alexander
A
Krüger
Anne
A
Tessmann
Grietje
G
Geissler
Ingrid
I
Kroemer
Heyo K
HK
Völzke
Henry
H
D000328:Adult; D000368:Aged; D000483:Alleles; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D005838:Genotype; D005858:Germany; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics* / Q000502:physiology; D008297:Male; D008565:Membrane Proteins / Q000235:genetics* / Q000502:physiology; D008875:Middle Aged; D009765:Obesity / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
C467727:INSIG2 protein, human; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins