Evaluation of aqueous leaves extract of Moringa oleifera Linn for wound healing in albino rats.
Aqueous extract of leaves of M. oleifera was investigated and rationalised for its wound healing activity. The aqueous extract was studied at dose level of 300 mg/kg body weight using resutured incision; excision and dead space wound models in rats. Significant increase in wound closure rate, skin-breaking strength, granuloma breaking strength, hydroxyproline content, granuloma dry weight and decrease in scar area was observed. The prohealing actions seem to be due to increased collagen deposition as well as better alignment and maturation. From the results obtained, it may be concluded that the aqueous extract of M. oleifera has significant wound healing property.
Rathi
B S
BS
Department of Pharmacology, Bharati Vidyapeeth Deemed University, Poona College of Pharmacy and Research Centre, Kothrud, Pune 411 038, India. badalrathi@rediffmail.com
Bodhankar
S L
SL
Baheti
A M
AM
D000818:Animals; D006097:Granulation Tissue / Q000187:drug effects / Q000473:pathology; D008297:Male; D051379:Mice; D029588:Moringa oleifera / Q000737:chemistry*; D010936:Plant Extracts / Q000627:therapeutic use*; D018515:Plant Leaves / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D011919:Rats, Inbred Strains; D012867:Skin / Q000187:drug effects / Q000473:pathology; D012997:Solvents / Q000494:pharmacology; D014867:Water / Q000494:pharmacology; D014945:Wound Healing / Q000187:drug effects*
D010936:Plant Extracts; D012997:Solvents; D014867:Water