title: Allogeneic bone marrow transplant for refractory mediastinal germ cell tumour: possible evidence of graft-versus-tumour effect.
abstract: Mediastinal germ cell tumours (GCT) carry a poor prognosis, particularly after relapse. We have reviewed the published reports of current treatments and describe a case with a cure after an allogeneic bone marrow transplant, which is not reported in the current published data. We believe that GCT may be susceptible to a graft-versus-tumour effect and suggest that patients with relapsed GCT be considered for allogeneic transplantation.
authors.affiliation: Westmead Hospital Medical Oncology Department, Westmead Hospital, Westmead, NSW, Australia. annabeg@westgate.wh.usyd.edu.au
authors.forename: A
authors.initials: A
authors.lastname: Goodwin
authors.forename: H
authors.initials: H
authors.lastname: Gurney
authors.forename: D
authors.initials: D
authors.lastname: Gottlieb
mesh_terms: D000328:Adult; D016026:Bone Marrow Transplantation / Q000379:methods*; D020350:Graft vs Tumor Effect; D006801:Humans; D008297:Male; D008479:Mediastinal Neoplasms / Q000601:surgery*; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis / Q000601:surgery; D009373:Neoplasms, Germ Cell and Embryonal / Q000601:surgery*; D014184:Transplantation, Homologous