title: Changes of epidermodysplasia verruciformis in benign skin lesions: the EV acanthoma.
abstract: Foci of histological changes of epidermodysplasia verruciformis (EV) were noted in five benign skin lesions. These skin lesions included an intradermal nevus, a pigmented seborrheic keratosis, an isolated papule on the forearm, a perianal lesion, and an acantholytic acanthoma. Because the changes resembled true EV so strongly despite the absence of clinical EV in these patients, we searched for EV-human papilloma virus (HPV) types in these skin lesions. Polymerase chain reaction (PCR) analysis on the formalin-fixed, paraffin-embedded blocks was performed. As a positive control, we included tissue from two HIV-positive patients with clinical EV proven by biopsy. Studies were also performed on five other archived biopsies that did not show changes of EV on multiple tissue sections. A nested PCR method detected EV-HPV types in three of the five benign skin lesions showing EV changes as well as in the positive controls. EV changes and EV-HPV can be found incidentally on biopsy in the absence of clinical EV; when such changes are the major histopathological finding in an isolated skin lesion, the lesion should be termed an EV acanthoma.
authors.affiliation: Yale-New Haven Hospital, New Haven, CT, USA. christine.ko@yale.edu
authors.forename: Christine J
authors.initials: CJ
authors.lastname: Ko
authors.forename: Thomas
authors.initials: T
authors.lastname: Iftner
authors.forename: Ronald J
authors.initials: RJ
authors.lastname: Barr
authors.forename: Scott W
authors.initials: SW
authors.lastname: Binder
mesh_terms: D049309:Acanthoma / Q000473:pathology* / Q000821:virology; D000328:Adult; D000368:Aged; D004819:Epidermodysplasia Verruciformis / Q000473:pathology* / Q000821:virology; D005260:Female; D006801:Humans; D017492:Keratosis, Seborrheic / Q000473:pathology / Q000821:virology; D008297:Male; D008875:Middle Aged; D009506:Nevus / Q000473:pathology / Q000821:virology; D027383:Papillomaviridae / Q000145:classification / Q000302:isolation & purification; D012871:Skin Diseases / Q000473:pathology* / Q000821:virology; D012878:Skin Neoplasms / Q000473:pathology* / Q000821:virology