Investigation of drug-porous adsorbent interactions in drug mixtures with selected porous adsorbents.
The adsorption of drugs onto porous substrates may prove to be a convenient method by which to enhance the dissolution rate of certain poorly water-soluble drugs in body fluids. The purpose of this research is to provide a better understanding of the type of interactions occurring between drugs and certain pharmaceutically acceptable porous adsorbents that leads to enhanced drug dissolution rates. The interactions between ibuprofen (acidic drug), acetaminophen (acidic drug), dipyridamole (basic drug), and the porous adsorbents used (calcium silicate and silica gel) were investigated using differential scanning calorimetry (DSC), powder X-ray diffraction (PXRD), and Fourier Transform infrared spectroscopy (FTIR). DSC and PXRD results indicated a significant loss of crystallinity of both ibuprofen and acetaminophen but not dipyridamole. In the case of ibuprofen, FTIR results indicated the ionization of the carboxylic group based on the shift in the FTIR carboxylic band. Dissolution of ibuprofen from its mixtures with porous adsorbents was found to be significantly higher compared to the neat drug, whereas dipyridamole dissolution from its mixtures with porous adsorbents was not significantly different from that of the neat drug.
Madieh
Shadi
S
University of Maryland, School of Pharmacy, 20 N. Pine St., Baltimore, Maryland 21201, USA.
Simone
Michael
M
Wilson
Wendy
W
Mehra
Dev
D
Augsburger
Larry
L
D000082:Acetaminophen / Q000008:administration & dosage / Q000737:chemistry; D000327:Adsorption; D017610:Calcium Compounds / Q000008:administration & dosage; D002152:Calorimetry, Differential Scanning; D016503:Drug Delivery Systems; D005079:Excipients; D007052:Ibuprofen / Q000008:administration & dosage / Q000737:chemistry; D016062:Porosity; D058428:Silica Gel; D017640:Silicates / Q000008:administration & dosage; D012822:Silicon Dioxide / Q000008:administration & dosage; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared; D014961:X-Ray Diffraction
D017610:Calcium Compounds; D005079:Excipients; D017640:Silicates; D000082:Acetaminophen; D058428:Silica Gel; D012822:Silicon Dioxide; C031293:calcium silicate; D007052:Ibuprofen