title: Nuclear factor-kappa B: a transcription factor for all seasons.
abstract: NF-kappaB, first discovered in 1986 in the nucleus of B cells as an immunoglobulin-kappa light chain enhancer, is today known as a transcription factor that is ubiquitously present in all cell types (not just B cells). It is conserved from drosophila to man, resides in the cytoplasm (not nucleus) in the resting state and binds to the promoter of > 400 different genes (not just immunoglobulin). Both NF-kappaB and TNF are essential components of the immune system, with their critical physiological role being in the immune defense.
authors.forename: Bharat B
authors.initials: BB
authors.lastname: Aggarwal
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000188:drug therapy / Q000235:genetics / Q000276:immunology; D006801:Humans; D016328:NF-kappa B / Q000235:genetics / Q000502:physiology* / Q000627:therapeutic use; D019636:Neurodegenerative Diseases / Q000188:drug therapy / Q000235:genetics / Q000276:immunology; D014157:Transcription Factors / Q000235:genetics / Q000276:immunology* / Q000627:therapeutic use
chemical_list: D016328:NF-kappa B; D014157:Transcription Factors