title: Gene-gene interaction analysis of personality traits in a Japanese population using an electrochemical DNA array chip analysis.
abstract: It has been suggested that genes involved in the central dopaminergic pathway may contribute to personality traits. However, the results of association studies for these genes have not been consistent. The present study investigated the relationship between the specific polymorphisms of MAO-A, COMT, DRD2, DRD3 and personality traits in Japanese women using a novel genotyping method involving electrochemical DNA array (ECA) chip analysis. Single marker association analysis for each mutation revealed no significant association between scores for Neuroticism Extraversion Openness-Five Factor Inventory (NEO-FFI) items. Gene-gene interaction analysis showed that a MAO-A 30-bp repeatxCOMT (Val158Met)xDRD3 (Ser9Gly) had a marginally significant association with Agreeableness (P=0.0547). The present results suggest that a combination of polymorphisms of MAO-A, COMT, and DRD3 might affect personality traits in Japanese women.
authors.affiliation: TUM Gene Inc., Chiba, Japan.
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Urata
authors.forename: Nagahide
authors.initials: N
authors.lastname: Takahashi
authors.forename: Yuko
authors.initials: Y
authors.lastname: Hakamata
authors.forename: Yoshimi
authors.initials: Y
authors.lastname: Iijima
authors.forename: Natsumi
authors.initials: N
authors.lastname: Kuwahara
authors.forename: Norio
authors.initials: N
authors.lastname: Ozaki
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Ono
authors.forename: Masahiko
authors.initials: M
authors.lastname: Amano
authors.forename: Toshiya
authors.initials: T
authors.lastname: Inada
mesh_terms: D000293:Adolescent; D000328:Adult; D044466:Asian People / Q000235:genetics; D001921:Brain / Q000378:metabolism*; D001923:Brain Chemistry / Q000235:genetics*; D002394:Catechol O-Methyltransferase / Q000235:genetics; D004252:DNA Mutational Analysis; D004298:Dopamine / Q000378:metabolism*; D005260:Female; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation / Q000235:genetics*; D005819:Genetic Markers / Q000235:genetics; D005820:Genetic Testing; D006801:Humans; D007564:Japan; D008995:Monoamine Oxidase / Q000235:genetics; D009419:Nerve Tissue Proteins / Q000235:genetics*; D020411:Oligonucleotide Array Sequence Analysis; D010551:Personality / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics; D017448:Receptors, Dopamine D2 / Q000235:genetics; D050637:Receptors, Dopamine D3 / Q000235:genetics
chemical_list: D005819:Genetic Markers; D009419:Nerve Tissue Proteins; D017448:Receptors, Dopamine D2; D050637:Receptors, Dopamine D3; D008995:Monoamine Oxidase; D002394:Catechol O-Methyltransferase; D004298:Dopamine