Induction of class II major histocompatibility complex expression in human multiple myeloma cells by retinoid.
Class II major histocompatibility complex (MHC II) is normally silenced in plasma/multiple myeloma (MM) cells at the transcriptional level through downregulation of class II transactivator (CIITA), allowing MM cells to escape from immunological responses. Here we demonstrate that a retinoic acid receptor-alpha/beta-selective retinoid Am80 (tamibarotene) could induce the expression of functional MHC II molecules in human MM cell lines. Am80 upregulated expression of the interferon regulatory factor-1 gene, followed by enhancement of CIITA expression. This is the first report demonstrating that retinoid can induce the expression of MHC II in terminally-differentiated plasma/MM cells.
Sanda
Takaomi
T
Department of Internal Medicine and Molecular Science, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, Aichi, Japan. tsanda@med.nagoya-cu.ac.jp
Iida
Shinsuke
S
Kayukawa
Satoshi
S
Ueda
Ryuzo
R
D016588:Anticarcinogenic Agents / Q000494:pharmacology; D001565:Benzoates / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D018076:DNA, Complementary / Q000378:metabolism; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D005802:Genes, MHC Class II / Q000235:genetics*; D000949:Histocompatibility Antigens Class II / Q000096:biosynthesis*; D006801:Humans; D019169:Jurkat Cells; D009101:Multiple Myeloma / Q000276:immunology* / Q000378:metabolism; D016328:NF-kappa B / Q000378:metabolism; D020411:Oligonucleotide Array Sequence Analysis; D012176:Retinoids / Q000378:metabolism*; D013764:Tetrahydronaphthalenes / Q000494:pharmacology*
D016588:Anticarcinogenic Agents; D001565:Benzoates; D018076:DNA, Complementary; D000949:Histocompatibility Antigens Class II; D016328:NF-kappa B; D012176:Retinoids; D013764:Tetrahydronaphthalenes; C061133:tamibarotene