title: Population-based epidemiology of rotavirus hospitalisations in Switzerland.
abstract: BACKGROUND
  Rotaviruses (RV) are the most common cause of dehydrating gastroenteritis requiring hospitalisation in children <5 years of age. A new generation of safe and effective RV vaccines is available. Accurate data describing the current burden of RV disease in the community are needed to devise appropriate strategies for vaccine usage.
  
  
  METHODS
  Retrospective, population-based analysis of RV hospitalisations in children <5 years of age during a 5-year period (1999-2003) in a both urban and rural area inhabited by 12% of the Swiss population.
  
  
  RESULTS
  Of 406 evaluable cases, 328 were community-acquired RV infections in children <5 years of age. RV accounted for 38% of all hospitalisations for gastroenteritis. The overall hospitalisation incidence in the <5-year-old was 1.5/1000 child-years (peak incidence, 2.6/1000 child-years in children aged 13-24 months). The incidence of community-acquired RV hospitalisations was significantly greater in children of non-Swiss origin (3.0 vs. 1.1/1000 child-years, relative risk 2.7; 95% CI 2.2-3.4), who were younger, but tended to be less severely dehydrated on admission than Swiss children. In comparison with children from urban areas, RV hospitalisation incidence was significantly lower among those residing in the remote mountain area (0.71 vs. 1.71/1000 child years, relative risk 2.2, 95% CI 1.6-3.1).
  
  
  CONCLUSIONS
  Population-based RV hospitalisation incidence was low in comparison with other European countries. Significantly greater hospitalisation rates among children living in urban areas and those from non-Swiss families indicate that factors other than the severity of RV-induced dehydration are important driving forces of hospital admission.
authors.affiliation: Department of Paediatrics, University of Bern, Bern, Switzerland.
authors.forename: Barbara
authors.initials: B
authors.lastname: Bucher
authors.forename: Christoph
authors.initials: C
authors.lastname: Aebi
mesh_terms: D017677:Age Distribution; D002675:Child, Preschool; D017714:Community-Acquired Infections / Q000453:epidemiology; D003428:Cross Infection / Q000453:epidemiology; D003681:Dehydration / Q000209:etiology; D003967:Diarrhea / Q000150:complications / Q000821:virology; D004641:Emigration and Immigration; D005260:Female; D005759:Gastroenteritis / Q000453:epidemiology* / Q000821:virology*; D006760:Hospitalization / Q000706:statistics & numerical data*; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D012189:Retrospective Studies; D012400:Rotavirus Infections / Q000453:epidemiology*; D012424:Rural Population; D012621:Seasons; D013557:Switzerland / Q000453:epidemiology; D014505:Urban Population