title: Collapse of skin antioxidant status during the subacute period of cutaneous radiation syndrome: a case report.
abstract: This case report describes a patient suffering from accidental cutaneous radiation syndrome. Clinical symptoms were characterized by the presence of moist epidermal denudation over approximately 8% of the body surface without signs of necrosis 88 days after radiation exposure. The skin transcriptional profile was obtained and provides a comprehensive overview of the changes in gene expression associated with skin wound healing after irradiation. In particular, our data show a specific set of genes, i.e. SOD1, GPX1, TDX1, TDX2 and HSP60, implicated in the redox control of normal skin repair after radiation exposure, whereas HOX1 and HOX2 were involved in the pathological skin repair. A reduction in the antioxidant capacity of the irradiated tissue concomitant with a progressive establishment of an uncontrolled inflammatory response was noted. Our data corroborate the hypothesis that ROS modulation is a key element of the healing response after cutaneous exposure to radiation and that the collapse of skin antioxidant status interferes directly with wound healing in skin after radiation exposure. Thus a better understanding of the molecular events through which oxidative stress modulates the healing response could result in a more rational therapeutic approach to the pathological process induced after exposure of skin to radiation.
authors.affiliation: Laboratoire de RadioPathologie, SRBE, DRPH, IRSN, Fontenay-aux Roses, France. marc.benderitter@irsn.fr
authors.forename: Marc
authors.initials: M
authors.lastname: Benderitter
authors.forename: Muriel
authors.initials: M
authors.lastname: Isoir
authors.forename: Valérie
authors.initials: V
authors.lastname: Buard
authors.forename: Valérie
authors.initials: V
authors.lastname: Durand
authors.forename: Christine
authors.initials: C
authors.lastname: Linard
authors.forename: Marie Catherine
authors.initials: MC
authors.lastname: Vozenin-Brotons
authors.forename: Jean
authors.initials: J
authors.lastname: Steffanazi
authors.forename: Hervé
authors.initials: H
authors.lastname: Carsin
authors.forename: Patrick
authors.initials: P
authors.lastname: Gourmelon
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D002467:Cell Nucleus / Q000378:metabolism; D016207:Cytokines / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D007249:Inflammation; D008297:Male; D010084:Oxidation-Reduction; D011832:Radiation Injuries / Q000175:diagnosis* / Q000378:metabolism*; D017382:Reactive Oxygen Species; D012867:Skin / Q000378:metabolism*; D013577:Syndrome; D014158:Transcription, Genetic; D014945:Wound Healing
chemical_list: D000975:Antioxidants; D016207:Cytokines; D017382:Reactive Oxygen Species