title: [Six clinical cases of relapsing polychondritis: review].
abstract: BACKGROUND
  Relapsing Polycondritis is a rare connective tissue disease of unknown aetiology that is manifested by inflammatory changes in cartilaginous tissues but the immune damage can spread and involve other tissues.
  
  
  METHODS
  Six patients with relapsing poycondritis treated in our service, between 1990 and 2003, were reviewed. The clinical features, age of onset, time from onset to diagnosis, disease associations and treatment were focused.
  
  
  RESULTS
  The female-to-male ratio in our series was 2:4, The median age onset of symptoms was 52 years. A diagnosis delay varied from 8 months to 4 years, with a median time of 18 months. All the five patients had auricular and nasal condritis, laringotracheal involvement was detected in four patients, arthralgia and arthritis also in four patients, cardiac involvement was present in two patients, myelodysplastic syndrome in one patient and ocular disease in four patients.
  
  
  CONCLUSIONS
  This is small sample study that differs from other studies in sex distribution. This disease is more frequent in females and in our sample men were more affected. The clinical manifestations and disease associations were similar to other populations. Calling attention is the best way to diminish time to diagnosis of this rare pathology.
authors.affiliation: Serviço de Reumatologia, Hospital de São João, Porto.
authors.forename: Patrícia
authors.initials: P
authors.lastname: Pinto
authors.forename: Iva
authors.initials: I
authors.lastname: Brito
authors.forename: José
authors.initials: J
authors.lastname: Brito
authors.forename: José
authors.initials: J
authors.lastname: Pinto
authors.forename: Francisco
authors.initials: F
authors.lastname: Ventura
mesh_terms: D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011081:Polychondritis, Relapsing / Q000175:diagnosis / Q000188:drug therapy; D012189:Retrospective Studies