title: Cost-effectiveness of a post-splenectomy registry for prevention of sepsis in the asplenic.
abstract: BACKGROUND
  Overwhelming, sometimes fatal infections represent a lifelong risk after surgical removal of the spleen, or in patients who develop hyposplenism as a consequence of illnesses. This risk may be reduced by all or a combination of vaccination, antibiotic prophylaxis and education. We aimed to determine if a registry approach to delivering these interventions would be cost effective using our own experience and published data.
  
  
  METHODS
  The decision model compared a cohort of 1,000 people covered by a registry to a cohort of 1,000 people with no registry. The impact of the registry was assessed in terms of achieved rates of vaccination, chemoprophylaxis and education, consequent outcomes of overwhelming post-splenectomy infection (OPSI) and mortality (years of life lived). The cost-effectiveness of the registry compared with no registry was estimated in terms of additional cost per case of OPSI avoided and as additional cost per life year gained.
  
  
  RESULTS
  In the first two years, the additional cost of the registry was dollar 152,611 per case of OPSI avoided or dollar 205,931 per life year gained. After this initial registration period the cost-effectiveness improves over time, such that over the cohort lifetime a post-splenectomy register is associated with an additional cost of dollar 105,159 per case of OPSI avoided or dollar 16,113 per life year gained.
  
  
  CONCLUSIONS
  A registry-based approach is likely to prove cost effective in terms of mortality and rates of OPSI avoided.
authors.affiliation: Department of Infectious Diseases, Alfred Hospital, Prahan, Victoria.
authors.forename: Ian
authors.initials: I
authors.lastname: Woolley
authors.forename: Penelope
authors.initials: P
authors.lastname: Jones
authors.forename: Denis
authors.initials: D
authors.lastname: Spelman
authors.forename: Lisa
authors.initials: L
authors.lastname: Gold
mesh_terms: D019072:Antibiotic Prophylaxis; D003362:Cost-Benefit Analysis; D005260:Female; D006801:Humans; D008297:Male; D008390:Markov Chains; D008875:Middle Aged; D011183:Postoperative Complications / Q000401:mortality / Q000517:prevention & control*; D012042:Registries; D012307:Risk Factors; D018805:Sepsis / Q000401:mortality / Q000517:prevention & control*; D013156:Splenectomy