Maternal human platelet antigen-1a antibody level correlates with the platelet count in the newborns: a retrospective study.
BACKGROUND
Maternal plasma and/or serum levels of anti-HPA-1a at delivery were compared to neonatal platelet (PLT) counts.


METHODS
Samples from HPA-1bb women who gave birth to children with thrombocytopenia or had anamnestic information about a previous child with neonatal alloimmune thrombocytopenia (NAIT) were collected at delivery. A modified monoclonal antibody immobilization of PLT antigen method was used for quantification of anti-HPA-1a.


RESULTS
The anti-HPA-1a level in women with severely thrombocytopenic children was higher than the corresponding level in mothers of children born with moderate thrombocytopenia or normal PLT counts.


CONCLUSIONS
Our data show a significant correlation between maternal anti-HPA-1a level and the neonatal PLT count and indicate strongly that this may be a reliable predictive measure for NAIT. Suitable test systems for quantitative measurements of anti-HPA-1a must be developed and evaluated for this particular purpose.
Killie
Mette Kjaer
MK
Department of Immunology and Transfusion Medicine, University Hospital of North Norway, Norway. mette.kjaer.killie@unn.no
Husebekk
Anne
A
Kaplan
Cecile
C
Taaning
Ellen
E
Skogen
Bjørn
B
D016824:Antigens, Human Platelet / Q000276:immunology*; D001323:Autoantibodies / Q000097:blood*; D036861:Delivery, Obstetric; D005260:Female; D006801:Humans; D007231:Infant, Newborn / Q000097:blood*; D039661:Integrin beta3; D007518:Isoantibodies / Q000097:blood*; D008499:Medical Records; D010976:Platelet Count; D011247:Pregnancy / Q000097:blood*; D012189:Retrospective Studies; D012720:Severity of Illness Index; D013921:Thrombocytopenia / Q000097:blood* / Q000151:congenital / Q000276:immunology*
D016824:Antigens, Human Platelet; D001323:Autoantibodies; C061248:ITGB3 protein, human; D039661:Integrin beta3; D007518:Isoantibodies