Efficient one-pot synthesis of fluorinated benzimidazolines, benzothiazolines, benzoxazolines, and dihydrobenzoxazinones using gallium(III) triflate as a catalyst.
One-pot synthesis of fluorinated benzimidazolines, benzothiazolines, benzoxazolines, and dihydrobenzoxazinones was easily achieved under mild conditions in high yields and purity through gallium(III) triflate mediated condensation-cyclization. Introduction of fluorine atoms favors the formation of the five-membered heterocycles over seven-membered heterocycles. [reaction: see text].
Prakash
G K Surya
GK
Loker Hydrocarbon Research Institute and Department of Chemistry, University of Southern California, Los Angeles, California 90089-1661, USA. gprakash@usc.edu
Mathew
Thomas
T
Panja
Chiradeep
C
Vaghoo
Habiba
H
Venkataraman
Karthik
K
Olah
George A
GA