title: A transdisciplinary model integrating genetic, physiological, and psychological correlates of voluntary exercise.
abstract: OBJECTIVE
  Physical inactivity contributes to as many as 250,000 premature deaths per year (R. R. Pate et al., 1995). The authors' objective was to test a transdisciplinary model of the ways in which genetic variants, physiological factors, and psychological factors are thought to influence exercise with 64 healthy, regular exercisers.
  
  
  METHODS
  In a within-subjects design, psychological and physiological responses to exercise were compared with responses to a sedentary activity.
  
  
  METHODS
  The authors measured affective state, perceived exertion, heart rate, and temperature change in response to moderate exercise versus sedentary activity. They also quantified genotypes on a single nucleotide polymorphism in the brain-derived neurotrophic factor (BDNF) gene.
  
  
  CONCLUSIONS
  The data show a relation between increases in positive affective states and acute exercise behavior, as opposed to a sedentary control. The BDNF gene moderated the effect of exercise on mood, heart rate, and perceived exertion. Physiological factors were, in turn, related to mood response, and mood response was a significant correlate of motivation to exercise in the future and of current exercise behavior. The model has potential as a framework for the basic study of the genetic, physiological, and psychological processes involved with voluntary exercise and as a tool for the applied examination of tailored exercise interventions and their efficacy for different subsets of individuals.
authors.affiliation: University of Colorado at Boulder, Department of Psychology, Boulder, CO 80309-0345, USA. angela.bryan@colorado.edu
authors.forename: Angela
authors.initials: A
authors.lastname: Bryan
authors.forename: Kent E
authors.initials: KE
authors.lastname: Hutchison
authors.forename: Douglas R
authors.initials: DR
authors.lastname: Seals
authors.forename: David L
authors.initials: DL
authors.lastname: Allen
mesh_terms: D000293:Adolescent; D000328:Adult; D000339:Affect / Q000502:physiology; D001833:Body Temperature Regulation / Q000235:genetics / Q000502:physiology; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics*; D015444:Exercise / Q000502:physiology* / Q000523:psychology*; D005260:Female; D005838:Genotype; D006339:Heart Rate / Q000235:genetics / Q000502:physiology; D006801:Humans; D008019:Life Style; D008297:Male; D009042:Motivation; D005082:Physical Exertion / Q000502:physiology; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D013223:Statistics as Topic
chemical_list: D019208:Brain-Derived Neurotrophic Factor