Expression of SpanX mRNA in testicular germ cell tumors.
The function of SpanX proteins is unknown, evidence is accumulating to suggest their involvement in tumorigenesis. A locus in Xq27, where the SpanX gene family is located, has been associated with testicular germ cell tumor (TGCT) onset. Therefore, we evaluated the presence of SpanX mRNA in six TGCT cases by RT-PCR. The results showed that SpanX mRNA is present in TGCT, confirming transcriptional activity of these genes in such tumors.
Salemi
Michele
M
Section of Endocrinology, Andrology and Internal Medicine, Department of Biomedical Sciences, University of Catania, Catania, Italy. msalemi@oasi.en.it
Calogero
Aldo E
AE
Bosco
Paolo
P
Castiglione
Roberto
R
La Vignera
Sandro
S
Borgione
Eugenia
E
Rappazzo
Giancarlo
G
Vicari
Enzo
E
D001483:Base Sequence; D041321:Chromosomes, Human, X / Q000235:genetics; D018076:DNA, Complementary / Q000235:genetics; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D009373:Neoplasms, Germ Cell and Embryonal / Q000235:genetics*; D009687:Nuclear Proteins / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D016415:Sequence Alignment; D013736:Testicular Neoplasms / Q000235:genetics*; D014158:Transcription, Genetic
D018076:DNA, Complementary; D009687:Nuclear Proteins; D012333:RNA, Messenger; C414403:SPANXA1 protein, human