Shiga toxin binding in normal and inflamed human intestinal mucosa.
Shiga toxins are associated with haemolytic uraemic syndrome but human intestinal epithelium does not express the Gb3 receptor. We describe Gb3 expression and Shiga toxin binding in histologically normal intestine and demonstrate that the pattern is unaltered in inflammatory disease states. Gb3 expression and Shiga toxin binding were identified in Paneth cells in both normal and inflamed mucosae.
Schüller
Stephanie
S
Centre for Paediatric Gastroenterology, Royal Free & University College Medical School, Rowland Hill Street, London NW3 2PF, UK. s.schuller@medsch.ucl.ac.uk
Heuschkel
Robert
R
Torrente
Franco
F
Kaper
James B
JB
Phillips
Alan D
AD
D015295:Antigens, Tumor-Associated, Carbohydrate / Q000096:biosynthesis* / Q000276:immunology; D006801:Humans; D007249:Inflammation / Q000378:metabolism / Q000382:microbiology; D015212:Inflammatory Bowel Diseases / Q000378:metabolism* / Q000382:microbiology; D007413:Intestinal Mucosa / Q000378:metabolism* / Q000382:microbiology / Q000473:pathology; D019879:Paneth Cells / Q000378:metabolism / Q000473:pathology; D022622:Shiga Toxin 1 / Q000378:metabolism*; D022641:Shiga Toxin 2 / Q000378:metabolism*
D015295:Antigens, Tumor-Associated, Carbohydrate; C472766:Gb3 antigen; D022622:Shiga Toxin 1; D022641:Shiga Toxin 2