Early inflammation in the airways of a cystic fibrosis foetus.
In cystic fibrosis patients, inflammation is often considered to be secondary to chronic infections. In the present study, we show increased levels of pro-inflammatory proteins in the lungs of a cystic fibrosis foetus compared to the lungs of two normal foetuses. Our findings suggest therefore the existence of an early intrinsic pro-inflammatory state in cystic fibrosis airways.
Verhaeghe
Catherine
C
Department of Human Genetics, Center for Biomedical Integrative Genoproteomics (CBIG), University of Liege, CHU Sart-Tilman B35, B-4000 Liege, Belgium.
Delbecque
Katty
K
de Leval
Laurence
L
Oury
Cecile
C
Bours
Vincent
V
D015415:Biomarkers / Q000378:metabolism; D001991:Bronchitis / Q000196:embryology* / Q000378:metabolism / Q000473:pathology; D003550:Cystic Fibrosis / Q000196:embryology* / Q000378:metabolism / Q000473:pathology; D016207:Cytokines / Q000378:metabolism*; D005260:Female; D005315:Fetal Diseases / Q000378:metabolism* / Q000473:pathology; D005455:Fluorescent Antibody Technique; D005865:Gestational Age; D006801:Humans; D007150:Immunohistochemistry; D008168:Lung / Q000378:metabolism / Q000473:pathology; D018613:Microscopy, Confocal; D016328:NF-kappa B / Q000378:metabolism*; D011247:Pregnancy; D011256:Pregnancy Outcome
D015415:Biomarkers; D016207:Cytokines; D016328:NF-kappa B