title: Long-term therapy of acute chronic liver failure to successful transplantation with an extracorporeal liver support system.
abstract: We report the case of a 38-year-old Caucasian male who was admitted because of end-stage liver failure due to primary sclerosing cholangitis. Because of the rapidly progressive severe hepatic encephalopathy and development of hepatorenal syndrome type I, the patient was immediately upgraded to a high priority status on the liver transplantation waiting list (T2 status according to Eurotransplant criteria). Intermittent therapy with an extracorporeal liver support system (Prometheus) was initiated in order to bridge the time period until the expected transplantation date. Under therapy with the extracorporeal liver support system, total serum bilirubin decreased significantly from 33 to 15 mg/dL after 8 sessions. Simultaneously the encephalopathy resolved gradually within 3 weeks (10 sessions) from initially grade 3 to grade 1. Extracorporeal detoxification therapy was continued for 51 days (23 sessions) until the patient underwent his successful liver transplantation in good general clinical condition. Prometheus, a new liver support system, seemed to sufficiently replace hepatic detoxification on a long-term basis in this patient with end-stage liver failure in order to bridge the time period until liver transplantation.
authors.affiliation: III. Medical Clinic--Department of Nephrology, J.-W.-Goethe-University, Frankfurt, Germany.
authors.forename: O
authors.initials: O
authors.lastname: Jung
authors.forename: A
authors.initials: A
authors.lastname: Asbe-Vollkopf
authors.forename: C
authors.initials: C
authors.lastname: Betz
authors.forename: W
authors.initials: W
authors.lastname: Caspary
authors.forename: H
authors.initials: H
authors.lastname: Geiger
authors.forename: D
authors.initials: D
authors.lastname: Faust
mesh_terms: D000328:Adult; D002908:Chronic Disease; D003131:Combined Modality Therapy; D005112:Extracorporeal Circulation / Q000379:methods*; D006801:Humans; D017114:Liver Failure, Acute / Q000175:diagnosis / Q000628:therapy*; D016031:Liver Transplantation / Q000379:methods*; D008297:Male; D011300:Preoperative Care / Q000379:methods*; D016896:Treatment Outcome