Presence of D8/17 B-cell marker in patients with poststreptococcal reactive arthritis.
An elevated expression of the alloantigen D8/17 on B lymphocytes has been previously proposed as a susceptibility marker in rheumatic fever. The aim of the study was to investigate the presence of the D8/17 marker on B lymphocytes in poststreptococcal reactive arthritis (PSRA). The study sample included 19 patients (15 boys, 4 girls; mean age 11.7 +/- 5.4 years) who were diagnosed with PSRA (mean age at diagnosis, 9.4 +/- 5.6 years) and 18 healthy controls (10 boys and 8 girls) matched for ethnic background. B-cell D8/17 expression was tested by flow cytometry assay using monoclonal antibodies. Laboratory results showed a higher expression of D8/17 in the patient group (23.1 +/- 10.4%, range 11.6-51.9%) than in the control group (17.1 +/- 8.2%, range 7.1-35.7) in controls; this difference was statistically significant after log transformation of the data (P = 0.035). The high rate of expression of the D8/17 marker in patients with PSRA suggests that RF and PSRA share the same genetic susceptibility.
Harel
Liora
L
Department of Pediatrics C, Schneider Children's Medical Center of Israel, Petach Tikvah, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. liorahar@clalit.org.il
Mukamel
Masha
M
Zeharia
Abraham
A
Kodman
Yona
Y
Prais
Dario
D
Uziel
Yosef
Y
Zabriskie
John B
JB
Amir
Jacob
J
D000293:Adolescent; D000328:Adult; D000944:Antigens, Differentiation, B-Lymphocyte / Q000235:genetics*; D016918:Arthritis, Reactive / Q000209:etiology / Q000235:genetics* / Q000382:microbiology; D001402:B-Lymphocytes / Q000378:metabolism; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D007519:Isoantigens / Q000032:analysis; D007557:Israel; D008297:Male; D012213:Rheumatic Fever / Q000235:genetics; D013290:Streptococcal Infections / Q000150:complications / Q000235:genetics*
D000944:Antigens, Differentiation, B-Lymphocyte; D007519:Isoantigens