title: MRI features of intrahepatic extramedullary haematopoiesis in sickle cell anaemia.
abstract: Extramedullary haematopoiesis (EMH) is a reactive mechanism by which blood cells are produced outside of the bone marrow to supplement insufficient production or increased destruction of erythrocytes. EMH is uncommon in sickle cell anaemia (SCA). We report the first case of focal intra-hepatic EMH in SCA depicted on MRI occurring in a 32-year-old woman with homozygote SCA and in view of previously published data, highlight the diagnostic features suggesting a differential diagnosis with other focal liver lesions including infectious, inflammatory or primary liver tumors.
authors.affiliation: Department of Radiology, Centre Hospitalo-Universitaire Henri Mondor, 51 Avenue du Maréchal de Lattre de Tassigny, 94010 Créteil, France.
authors.forename: Mohamed Ali
authors.initials: MA
authors.lastname: Jelali
authors.forename: Alain
authors.initials: A
authors.lastname: Luciani
authors.forename: Hicham
authors.initials: H
authors.lastname: Kobeiter
authors.forename: Serge
authors.initials: S
authors.lastname: Zafrani
authors.forename: Marie Christine
authors.initials: MC
authors.lastname: Anglade
authors.forename: Benhalima
authors.initials: B
authors.lastname: Zegai
authors.forename: Dora
authors.initials: D
authors.lastname: Bachir
authors.forename: Alain
authors.initials: A
authors.lastname: Rahmouni
mesh_terms: D000328:Adult; D000755:Anemia, Sickle Cell / Q000150:complications*; D005260:Female; D006411:Hematopoiesis, Extramedullary; D006801:Humans; D008099:Liver; D008279:Magnetic Resonance Imaging