title: [Expression of Survivin and its correlation with tumor angiogenesis in differentiated thyroid carcinomas].
abstract: OBJECTIVE
  To identify the expression of Survivin and its relationship with tumor angiogenesis in differentiated thyroid carcinomas.
  
  
  METHODS
  The expression of Survivin, VEGF and MVD were detected by immuno-histochemical staining (SP methods) in 47 differentiated thyroid carcinomas, 10 thyroid adenoma and 10 normal thyroid tissues and their content were measured by pathological image analysis system.
  
  
  RESULTS
  The expression of Survivin and VEGF in differentiated thyroid carcinomas was 46.8% and 61.7%, respectively. No expression of Survivin was detected in thyroid adenoma and normal thyroid tissues. The expression of Survivin was significantly correlated with the expression of VEGF and MVD in differentiated thyroid carcinomas. The expression of Survivin was significantly associated with clinical stages, tumor complete capsule and lymph node metastasis.
  
  
  CONCLUSIONS
  The up-regulation of Survivin expression and its close relationship with angiogenesis may play an important role in carcinogenesis and development of differentiated thyroid carcinomas.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Bethune International Peace Hospital of PLA, Shijiazhuang 050061, China. Dongwr1212@sina.com
authors.forename: Wenrong
authors.initials: W
authors.lastname: Dong
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Li
authors.forename: Xiuying
authors.initials: X
authors.lastname: Lu
authors.forename: Bin
authors.initials: B
authors.lastname: Di
authors.forename: Jing
authors.initials: J
authors.lastname: Ma
authors.forename: Liping
authors.initials: L
authors.lastname: Cui
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins; D008207:Lymphatic Metastasis; D008297:Male; D008869:Microtubule-Associated Proteins / Q000235:genetics / Q000378:metabolism*; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000235:genetics / Q000378:metabolism; D009389:Neovascularization, Pathologic; D000077022:Survivin; D013964:Thyroid Neoplasms / Q000098:blood supply* / Q000378:metabolism* / Q000473:pathology; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics / Q000378:metabolism; D055815:Young Adult
chemical_list: C107489:BIRC5 protein, human; D051034:Inhibitor of Apoptosis Proteins; D008869:Microtubule-Associated Proteins; D009363:Neoplasm Proteins; D000077022:Survivin; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A