Biological response of new activated acrylic bone cements with antiseptic properties. Histomorphometric analysis.
The biological response to an acrylic bone cement cured with 4,4'-bis-dimethylamino benzydrol (BZN) as activator of reduced cytotoxicity and antiseptic properties, has been carried out and compared with that obtained for CMW 3 cement. Histomorphometrical data (undecalcified trichromic Goldner staining) were obtained by measuring the most significant variables at the bone-cement interface. Quantitative results of tissue response revealed that newly formed bone and connective tissue were maximum at 4 weeks whereas bone marrow increased with time of implantation for both cements. Statistical analysis (p < 0.05) showed no significant differences in newly formed bone and bone marrow with time and between both groups, however, connective tissue significantly decreased between 4 weeks and 12 weeks for BZN cement, and between 12 weeks and 24 weeks for CMW3. By comparing both cements at each time, lower significant percentage of connective tissue at the bone-cement interface of the BZN cement, was obtained at 12 and 24 weeks, however, a very low amount of connective tissue was found for both cements. All the results indicate that the new activated system could be applied clinically in a relatively short time, after the corresponding preclinical study.
de la Torre
B
B
Instituto de Ciencia y Tecnología de Polímeros, Madrid, Spain.
Salvado
M
M
Corchón
M A González
MA
Vázquez
B
B
Collía
F
F
De Pedro
J A
JA
San Román
J
J
D000818:Animals; D000891:Anti-Infective Agents, Local / Q000737:chemistry* / Q000494:pharmacology*; D001559:Benzhydryl Compounds; D001843:Bone Cements / Q000737:chemistry* / Q000494:pharmacology*; D001853:Bone Marrow / Q000033:anatomy & histology; D003238:Connective Tissue / Q000033:anatomy & histology; D005260:Female; D005269:Femur / Q000033:anatomy & histology / Q000187:drug effects / Q000601:surgery; D008422:Materials Testing; D008768:Methylmethacrylates / Q000737:chemistry / Q000494:pharmacology; D019904:Polymethyl Methacrylate / Q000737:chemistry / Q000494:pharmacology; D011817:Rabbits; D013997:Time Factors
D000891:Anti-Infective Agents, Local; D001559:Benzhydryl Compounds; D001843:Bone Cements; D008768:Methylmethacrylates; C002837:4,4'-bis(dimethylamino)benzhydrol; C035124:CMW cement; D019904:Polymethyl Methacrylate