Event-related potentials in idiopathic rapid eye movements sleep behaviour disorder.
OBJECTIVE
To assess psychophysiological parameters in idiopathic rapid eye movements sleep behaviour disorder (RBD), in order to identify possible markers for pre or sub-clinical cognitive abnormalities.


METHODS
Sixteen consecutive unmedicated patients with idiopathic RBD and 16 age- and sex-matched controls performed active and passive auditory oddball paradigms and an attentional test.


RESULTS
There were no significant between-group latency and amplitude differences. The two groups showed a difference in the inter-peak interval between N100 and P200 in the active condition. A significant correlation between attentional matrices scores and N100 amplitude at Fz and Cz to standard stimuli in the passive condition was found in controls but not in patients.


CONCLUSIONS
In RBD there are minimal event-related potentials (ERPs) abnormalities involving the early stages of information processing.


CONCLUSIONS
ERPs are not sensitive to pre or sub-clinical cognitive abnormalities in RBD. In alternative, these findings might support the existence of a truly idiopathic RBD syndrome.
Raggi
Alberto
A
Department of Neurology and Neurorehabilitation, San Raffaele Turro Hospital, Via Stamira d'Ancona 20, 20127 Milan, Italy. raggi.alberto@hsr.it
Manconi
Mauro
M
Consonni
Monica
M
Martinelli
Cristina
C
Zucconi
Marco
M
Cappa
Stefano F
SF
Ferini-Strambi
Luigi
L
D000368:Aged; D016022:Case-Control Studies; D003072:Cognition Disorders / Q000175:diagnosis / Q000503:physiopathology; D003265:Contingent Negative Variation / Q000502:physiology; D004569:Electroencephalography; D004576:Electromyography; D005071:Evoked Potentials / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017286:Polysomnography; D011446:Prospective Studies; D020187:REM Sleep Behavior Disorder / Q000503:physiopathology*; D012895:Sleep, REM / Q000502:physiology*