title: TRPC7.
abstract: Canonical transient receptor potential7 (TRPC7) is the seventh identified member of the mammalian TRPC channel family, comprising nonselective cation channels activated through the phospholipase C (PLC) signaling pathway. TRPC7 is directly activated by diacylglycerol (DAG), one of the PLC products, having high sequence homologywith TRPC3 and TRPC6, which are also activated by DAG. TRPC7 shows unique properties of activation, such as constitutive activity and susceptibility to negative regulation by extracellular Ca2+. Although the physiological importance of TRPC7 in the native environment remains elusive, TRPC7 would play important roles in Ca2+ signaling pathway through these characteristic features.
authors.affiliation: Laboratory of Molecular Biology, Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, 615-8510 Kyoto, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Numaga
authors.forename: M
authors.initials: M
authors.lastname: Wakamori
authors.forename: Y
authors.initials: Y
authors.lastname: Mori
mesh_terms: D000818:Animals; D001711:Biotransformation / Q000502:physiology; D018076:DNA, Complementary / Q000096:biosynthesis / Q000235:genetics; D006801:Humans; D007473:Ion Channels / Q000187:drug effects / Q000502:physiology; D050052:TRPC Cation Channels / Q000235:genetics* / Q000378:metabolism / Q000502:physiology*; D014018:Tissue Distribution
chemical_list: D018076:DNA, Complementary; D007473:Ion Channels; D050052:TRPC Cation Channels; C498501:TRPC7 protein, human; C498502:Trpc7 protein, mouse