Detailed analysis of the response of different cell lines to carbon irradiation.
Published survival data for Chinese hamster ovarian cells CHO-K1 and their radiosensitive mutant xrs5 after irradiation by carbon ions of energies from 2.4 to 266.4 MeV u(-1) have been analysed using the probabilistic two-stage radiobiological model, which enables to represent the interplay of damage induction and repair processes. The results give support for the hypothesis that the differences in radiation sensitivity of diverse cell lines are given primarily by their different repair capabilities, and indicate the need for explicitly representing the outcome of repair processes in radiobiological models and treatment-planning approaches in radiotherapy.
Hromcíková
Hana
H
Institute of Physics, Academy of Sciences of the Czech Republic, Na Slovance 2, 18221 Praha 8, Czech Republic. Hromcikova@seznam.cz
Kundrát
Pavel
P
Lokajícek
Milos
M
D000818:Animals; D016466:CHO Cells; D002250:Carbon Radioisotopes; D002470:Cell Survival / Q000528:radiation effects*; D003198:Computer Simulation; D006224:Cricetinae; D003412:Cricetulus; D004247:DNA / Q000737:chemistry* / Q000528:radiation effects*; D004249:DNA Damage; D004307:Dose-Response Relationship, Radiation; D018499:Linear Energy Transfer; D008954:Models, Biological; D008956:Models, Chemical; D008958:Models, Molecular; D011829:Radiation Dosage; D011839:Radiation, Ionizing
D002250:Carbon Radioisotopes; D004247:DNA