Serum activity of dipeptidyl peptidase IV (DPPIV; EC 3.4.14.5) in breast-fed infants with symptoms of allergy.
Beta-casomorphins, opioid peptides present in mother's milk, are a good substrate for DPPIV (EC 3.4.14.5) which is a major factor limiting the half-life of biologically active peptides. Serum DPPIV activity of two groups of infants (healthy and atopic dermatitis) and contents of beta-casomorphin-5 and -7 in their mothers' milk were determined in the study. We have found correlation between those two parameters in the group of children with atopic dermatitis syndromes, while no such a correlation was found in the control group.
Jarmołowska
Beata
B
University of Warmia and Mazury, ul. Oczapowskiego 1A, 10-719 Olsztyn, Poland.
Bielikowicz
Krzysztof
K
Iwan
Małgorzata
M
Sidor
Katarzyna
K
Kostyra
Elzbieta
E
Kaczmarski
Maciej
M
D000243:Adenosine Deaminase / Q000097:blood*; D001942:Breast Feeding; D016022:Case-Control Studies; D003876:Dermatitis, Atopic / Q000201:enzymology* / Q000209:etiology; D018819:Dipeptidyl Peptidase 4 / Q000097:blood*; D004723:Endorphins / Q000378:metabolism; D005260:Female; D006023:Glycoproteins / Q000097:blood*; D006801:Humans; D007223:Infant; D008895:Milk, Human / Q000378:metabolism*; D010446:Peptide Fragments / Q000378:metabolism
D004723:Endorphins; D006023:Glycoproteins; D010446:Peptide Fragments; C041128:beta-casomorphin 7; C034812:beta-casomorphin 5; C042807:DPP4 protein, human; D018819:Dipeptidyl Peptidase 4; D000243:Adenosine Deaminase