title: Computerized cytomorphometric analysis of nuclear area, nuclear perimeter and mean nuclear diameter in spontaneous canine mammary gland tumours.
abstract: Fifty-two spontaneous canine mammary gland tumours (fibroadenomas (n=8), tubulopapillary carcinomas (n=9), solid carcinomas (n=6), anaplastic carcinomas (n=7), fibrosarcomas (n=9), liposarcomas (n=9) and osteosarcomas (n=4) were analysed by computer-assisted nuclear morphometry in Hemacolor-stained cytological specimens. Computerized cytomorphometry was performed and the nuclear area, nuclear perimeter and mean nuclear diameter of investigated tumours were assessed. A minimum of 100 nuclei per lesion were examined. The statistical analysis revealed statistically significant differences between benign and malignant neoplasms. The results indicated that computer-assisted nuclear morphometry could be used as an additional method for differentiation of benign from malignant canine mammary gland tumours in cytological specimens.
authors.affiliation: Department of General and Clinical Pathology of Animals, Trakia University, Stara Zagora, Bulgaria. simeonov@vereya.net
authors.forename: R
authors.initials: R
authors.lastname: Simeonov
authors.forename: G
authors.initials: G
authors.lastname: Simeonova
mesh_terms: D000818:Animals; D001331:Automation; D002467:Cell Nucleus; D003584:Cytological Techniques / Q000379:methods / Q000662:veterinary*; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D005260:Female; D006652:Histological Techniques / Q000379:methods / Q000662:veterinary*; D015674:Mammary Neoplasms, Animal / Q000473:pathology*