An increased lung cancer risk associated with codon 72 polymorphism in the TP53 gene and human papillomavirus infection in Mazandaran province, Iran.
The TP53 gene has a polymorphism in exon 4 at codon 72 that presents the arginine or proline genotype. The association of TP53 codon 72 polymorphism with lung cancer risk has been studied by several groups, although with inconsistent results. Our previous study showed that the human papillomavirus (HPV) infection is associated with the development of lung cancer in Mazandaran, north part of Iran (cases=25.6% versus controls=9.0%, P=0.002). The frequency of TP53 codon 72 polymorphism was studied in a north part Iranian group of 92 healthy controls and 141 lung cancer patients. The allelic distribution of the three genotypes (ArgArg, ArgPro, ProPro) in healthy normal controls was 46.1, 32.6 and 21.3%, respectively, which differs from that of lung cancer patients showing genotype frequency as 42.6, 49.6 and 7.8%. A relation between the presence of the Arg allele and lung cancer risk was observed. Our study reveals that Arg allele, active smoking and HPV infection are the important risk factors in lung cancer development in the north part of Iran, Mazandaran province.
Nadji
Seyed Alireza
SA
Virology Division, Department of Pathobiology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. sarnadji@razi.tums.ac.ir
Mahmoodi
Mahmood
M
Ziaee
Abed Ali
AA
Naghshvar
Farshad
F
Torabizadeh
Jila
J
Yahyapour
Yousef
Y
Nategh
Rakhshandeh
R
Mokhtari-Azad
Talat
T
D016022:Case-Control Studies; D003062:Codon / Q000235:genetics; D005260:Female; D016158:Genes, p53; D005838:Genotype; D006801:Humans; D007492:Iran / Q000453:epidemiology; D008175:Lung Neoplasms / Q000453:epidemiology / Q000235:genetics* / Q000821:virology*; D008297:Male; D030361:Papillomavirus Infections / Q000150:complications*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects
D003062:Codon