Elevated cerebrospinal fluid F2-isoprostane levels indicating oxidative stress in healthy siblings of multiple sclerosis patients.
Lipid peroxidation has been implicated in the pathogenesis of multiple sclerosis (MS). Isoprostanes, isomers of prostaglandins, are produced by free radical-mediated peroxidation of fatty acids in vivo and can be quantified in biological fluids. This study examines the levels of cerebrospinal fluid (CSF) F2-isoprostanes (F2-iPs) in MS patients (n=46), their healthy siblings (n=46) and unrelated controls (n=50). The median CSF F2-iP concentration (range) was significantly higher in siblings of MS patients, as compared to healthy controls (40.0 [7.1-68.7] and 29.1 [6.4-60.3] pg/mL, respectively, p=0.031). MS patients demonstrated F2-iP levels intermediate between siblings and controls. F2-iP levels in MS patients and siblings correlated significantly (R=0.360, p=0.012). These results suggest that siblings of MS patients have an increased oxidative stress response to environmental and/or genetic factors that may be involved in MS pathogenesis.
Mattsson
Niklas
N
Clinical Neurochemistry Laboratory, Department of Neuroscience and Physiology, Sahlgren's University Hospital, S-431 80 Mölndal, Sweden.
Haghighi
Sara
S
Andersen
Oluf
O
Yao
Yuemang
Y
Rosengren
Lars
L
Blennow
Kaj
K
Praticò
Domenico
D
Zetterberg
Henrik
H
D000328:Adult; D000368:Aged; D002490:Central Nervous System / Q000378:metabolism / Q000503:physiopathology; D004781:Environmental Exposure; D028441:F2-Isoprostanes / Q000032:analysis / Q000134:cerebrospinal fluid*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000134:cerebrospinal fluid* / Q000235:genetics / Q000503:physiopathology; D018384:Oxidative Stress / Q000235:genetics*; D035781:Siblings; D015854:Up-Regulation / Q000235:genetics*
D028441:F2-Isoprostanes