title: [A follow-up of patients with anterior optic tract glioma concurrent with type 1 neurofibromatosis].
abstract: Fifty-nine patients with anterior optic tract (AOT) lesion concurrent with type neurofibromatosis (NF-1) were followed up for 1 to 36 years (median 5 years). Based on the study, the authors identified several grades of the disease: - stabilization without intervention; - stabilization after treatment; - insignificant negative changes as a slight tumor growth and a further stabilization of the process; - occasionally negative changes irrespective of treatment. The behavior of a tumor is unpredictable. The onset of progression in infancy is a poor predictor. Ophthalmological symptoms are not the criterion that can be used to make a prognosis. The prognosis is largely determined by neurovisualization techniques and primarily magnetic resonance imaging. A uniform slight thickening of AOT structures irrespective of the extent of the process along the AOT should be referred to as a good prognosis. There was no spontaneous tumor regression in any case. By taking into account the beneficial effect of radiotherapy, the authors consider it expedient to use it as monotherapy and in combination with surgery. Bypass surgery on the spinal fluid system frequently fails to entirely solve the problem intracranial hypertension.
authors.forename: N K
authors.initials: NK
authors.lastname: Serova
authors.forename: L A
authors.initials: LA
authors.lastname: Lazareva
authors.forename: S K
authors.initials: SK
authors.lastname: Gorelychev
authors.forename: V I
authors.initials: VI
authors.lastname: Ozerova
authors.forename: I N
authors.initials: IN
authors.lastname: Pronin
mesh_terms: D001766:Blindness / Q000209:etiology; D018450:Disease Progression; D005500:Follow-Up Studies; D006801:Humans; D007427:Intracranial Pressure; D008279:Magnetic Resonance Imaging; D009456:Neurofibromatosis 1 / Q000150:complications*; D009897:Optic Chiasm / Q000473:pathology; D020339:Optic Nerve Glioma / Q000145:classification / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D011379:Prognosis; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D014786:Vision Disorders / Q000209:etiology; D014792:Visual Acuity; D014795:Visual Pathways / Q000473:pathology