Bioassay-guided isolation of antifungal alkaloids from Melochia odorata.
An alkaloidal extract of the leaves of Melochia odorata exhibited antifungal activity against Candida albicans, Cryptococcus neoformans and Saccharomyces cerevisiae using a TLC bioautographic method. Bioassay-guided fractionation of this extract using separation by normal and reverse high-performance liquid chromatography (HPLC) resulted in the isolation of two active compounds identified as frangulanine, a cyclic peptide alkaloid, and waltherione-A, a quinolinone alkaloid.
Emile
Aurélie
A
Laboratoire de Pharmacognosie UMR 8076 CNRS, Faculté de Pharmacie, Université Paris-Sud, rue J.B. Clément, 92296 Châtenay-Malabry cedex, France.
Waikedre
Jean
J
Herrenknecht
Christine
C
Fourneau
Christophe
C
Gantier
Jean-Charles
JC
Hnawia
Edouard
E
Cabalion
Pierre
P
Hocquemiller
Reynald
R
Fournet
Alain
A
D000470:Alkaloids / Q000302:isolation & purification* / Q000494:pharmacology; D000935:Antifungal Agents / Q000302:isolation & purification* / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects; D003455:Cryptococcus neoformans / Q000187:drug effects; D019660:Malvaceae / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D018515:Plant Leaves / Q000737:chemistry; D012441:Saccharomyces cerevisiae / Q000187:drug effects
D000470:Alkaloids; D000935:Antifungal Agents