title: [Marchiafava-Bignami disease].
abstract: Marchiafava-Bignami disease (MBD) is a rare central nervous system disorder of an unknown etiology strongly associated with alcoholism. MBD primarily affects the corpus callosum leading to confusion, dysarthria, seizures and frequently to death. About 250 cases of different races and nationalities, mostly alcoholics have been reported. We report a single-case study of a 43-year-old woman with the history of severe alcohol abuse, who demonstrated typical picture of Marchiafava-Bignami disease (MBD) with fatal course. We reviewed the literature on cases of MBD.
authors.affiliation: Z Katedry i Kliniki Neurologii, Collegium Medicum im. Ludwika Rydygiera, Bydgoszczy. bkukulska@yahoo.com
authors.forename: Beata
authors.initials: B
authors.lastname: Kukulska-Pawluczuk
authors.forename: Robert
authors.initials: R
authors.lastname: Princ
authors.forename: Malgorzata
authors.initials: M
authors.lastname: Burzyńska-Makuch
authors.forename: Alina
authors.initials: A
authors.lastname: Borkowska
mesh_terms: D000328:Adult; D020268:Alcohol-Induced Disorders, Nervous System / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D000437:Alcoholism / Q000150:complications; D001927:Brain Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology / Q000473:pathology; D003337:Corpus Callosum / Q000473:pathology*; D003711:Demyelinating Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology / Q000473:pathology; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D019636:Neurodegenerative Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology / Q000473:pathology; D013831:Thiamine / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed
chemical_list: D013831:Thiamine