title: [A case of drug-induced pneumonitis due to levofloxacin and kampo medicine].
abstract: A 55-year-old woman was admitted to our hospital because of dyspnea on exertion. Hypoxemia and restrictive ventilatory impairment were observed on admission. Chest radiographs showed diffuse patchy infiltration shadows in both lungs. We suspected drug-induced pneumonitis, because her history of fever seemed to be related to drug administration for sinusitis. Her symptoms and findings were gradually decreased by discontinuation of the drugs. Transbronchial lung biopsy specimens showed lymphocyte dominant infiltration in the alveolar septa and Masson bodies. Drug lymphocyte stimulation tests were positive for levofloxacin and shin-i-seihai-to, a kampo medicine. On the basis of these findings, we arrived at a diagnosis of drug-induced pneumonitis caused by these drugs.
authors.affiliation: Nakagami Hospital.
authors.forename: Masaki
authors.initials: M
authors.lastname: Tohyama
authors.forename: Noriko
authors.initials: N
authors.lastname: Arakaki
authors.forename: Kazunori
authors.initials: K
authors.lastname: Tamaki
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Shimoji
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage* / Q000009:adverse effects; D005260:Female; D006801:Humans; D064704:Levofloxacin; D020835:Medicine, Kampo; D008875:Middle Aged; D015242:Ofloxacin / Q000009:adverse effects*; D011014:Pneumonia / Q000139:chemically induced*; D012852:Sinusitis / Q000188:drug therapy
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004365:Drugs, Chinese Herbal; C517595:shin-i-seihai-to; D064704:Levofloxacin; D015242:Ofloxacin