title: Uteroglobin-related protein 1 and clara cell protein in induced sputum of patients with asthma and rhinitis.
abstract: BACKGROUND
  Uteroglobin-related protein 1 (UGRP1) and Clara cell protein (CC16), members of the secretoglobin family, increasingly appear to play a role in airway inflammatory response.
  
  
  OBJECTIVE
  To explore levels of UGRP1 and CC16 in induced sputum of patients with asthma and rhinitis.
  
  
  METHODS
  Induced-sputum samples of patients with asthma or rhinitis (n = 32 each; atopic asthma, n = 24; atopic rhinitis, n = 20) and from 19 nonsmoking nonatopic control subjects were analyzed for cytology and levels of UGRP1, CC16, and albumin.
  
  
  RESULTS
  Sputum UGRP1 increased in both asthma and rhinitis, most strikingly so in asthma, in which changes were most significant in atopic individuals. By contrast, sputum CC16 did not change significantly in either condition, although it was positively correlated with UGRP1 in patients and control subjects. Changes in sputum UGRP1 in atopic asthma were not linked to permeability changes reflected by increased albumin levels but correlated positively with sputum macrophages and negatively with eosinophils. The observed differences in UGRP1 and CC16 may be linked to different cell populations being responsible for their secretion; UGRP1 is mainly secreted in larger conducting airways, whereas CC16 is mainly secreted by the nasal and peripheral airways epithelium.
  
  
  CONCLUSIONS
  The increase in UGRP1 but not of CC16 in asthma and rhinitis suggests that UGRP1 may play a role in these inflammatory diseases.
authors.affiliation: Unit of Industrial Toxicology and Occupational Medicine, Université Catholique de Louvain, Clos Chapelle-aux-Champs 30, bte 3054, B-1200 Brussels, Belgium.
authors.forename: Claire
authors.initials: C
authors.lastname: de Burbure
authors.forename: Patrizia
authors.initials: P
authors.lastname: Pignatti
authors.forename: Massimo
authors.initials: M
authors.lastname: Corradi
authors.forename: Mario
authors.initials: M
authors.lastname: Malerba
authors.forename: André
authors.initials: A
authors.lastname: Clippe
authors.forename: Xavier
authors.initials: X
authors.lastname: Dumont
authors.forename: Gianna
authors.initials: G
authors.lastname: Moscato
authors.forename: Antonio
authors.initials: A
authors.lastname: Mutti
authors.forename: Alfred
authors.initials: A
authors.lastname: Bernard
mesh_terms: D000328:Adult; D001249:Asthma / Q000276:immunology* / Q000378:metabolism*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D012044:Regression Analysis; D012129:Respiratory Function Tests; D012220:Rhinitis / Q000276:immunology* / Q000378:metabolism*; D013183:Sputum / Q000276:immunology*; D014598:Uteroglobin / Q000378:metabolism*
chemical_list: C556389:SCGB1A1 protein, human; D014598:Uteroglobin