title: Changes in estrogen receptors alpha and beta expression in the brain of mice exposed prenatally to bisphenol A.
abstract: The expression of ERs alpha and beta and serotonergic neurons were evaluated in the brains of mice prenatally exposed to Bisphenol A, a known endocrine disrupting chemical (EDc). Bisphenol A was administered orally at a dose of 2ng/g body weight on gestinational days 11-17 to pregnant ICR mice. Newborn male offspring (Bis-A mice) were evaluated for the immunoreactivity of ERs alpha and beta, serotonin, and serotonin transporter positive cells in the dorsal raphe nucleus (DRN). The serum testosterone level was also evaluated. In the Bis-A mice, the expression of ERs alpha and beta at 5 and 13 weeks was increased compared with the controls (P<0.04), but this difference disappeared by the 9th week. The serotonin, serotonin transporter, and testosterone level differences between two groups did not reach significance. Exposure to bisphenol A may have changed the expression of ERs in the brain, but did not directly affect serotonin neurons in the DRN.
authors.affiliation: Department of Psychosomatic Medicine, Graduate School of Medical Sciences, Kyushu University, Japan. kawai@cephal.med.kyushu-u.ac.jp <kawai@cephal.med.kyushu-u.ac.jp>
authors.forename: Keisuke
authors.initials: K
authors.lastname: Kawai
authors.forename: Shuji
authors.initials: S
authors.lastname: Murakami
authors.forename: Emiko
authors.initials: E
authors.lastname: Senba
authors.forename: Takeharu
authors.initials: T
authors.lastname: Yamanaka
authors.forename: Yuya
authors.initials: Y
authors.lastname: Fujiwara
authors.forename: Chikako
authors.initials: C
authors.lastname: Arimura
authors.forename: Takehiro
authors.initials: T
authors.lastname: Nozaki
authors.forename: Masato
authors.initials: M
authors.lastname: Takii
authors.forename: Chiharu
authors.initials: C
authors.lastname: Kubo
mesh_terms: D000818:Animals; D001559:Benzhydryl Compounds; D001921:Brain; D047628:Estrogen Receptor alpha / Q000187:drug effects* / Q000378:metabolism; D047629:Estrogen Receptor beta / Q000187:drug effects* / Q000378:metabolism; D004968:Estrogens, Non-Steroidal / Q000494:pharmacology / Q000633:toxicity*; D005260:Female; D005333:Fetus / Q000187:drug effects; D005786:Gene Expression Regulation / Q000187:drug effects; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010636:Phenols / Q000494:pharmacology / Q000633:toxicity*; D011247:Pregnancy; D012701:Serotonin / Q000378:metabolism; D050486:Serotonin Plasma Membrane Transport Proteins / Q000187:drug effects / Q000378:metabolism; D013739:Testosterone / Q000097:blood; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D047628:Estrogen Receptor alpha; D047629:Estrogen Receptor beta; D004968:Estrogens, Non-Steroidal; D010636:Phenols; D012701:Serotonin; D050486:Serotonin Plasma Membrane Transport Proteins; D013739:Testosterone; C006780:bisphenol A; D000098826:Bisphenol A Compounds