title: [Coronary artery disease--relevance of total coronary revascularization on the incidence of malignant arrhythmias].
abstract: Myocardial ischemia induces redistribution of different ions (H(+), K(+), Na(+), Ca(++)) across the cardiomyocyte membrane, as well as the loss of intracellular ATP content. This results in changes in the electrical properties including shortening of the action potential, appearance of delayed afterpotentials, and a modified refractoriness of the cardiomyocyte. These changes may induce or support malignant cardiac arrhythmias. Supersensitivity of sympathetic denervated myocardium may further support the electrical instability of ischemic myocardium.Virtues of studies indicate that patients with coronary artery disease who develop complex arrhythmias during or after exercise bear a substantially increased risk for sudden cardiac death. Other studies report about arrhythmic stabilization and reduced mortality if patients with reversible myocardial ischemia receive complete revascularization. However, none of these studies is without methodological flaws. Due to the lack of methodologically sound studies in sufficiently large patient cohorts, the question whether complete coronary revascularisation improves the prognosis of patients with coronary artery disease and which strategy (medical, interventional, or surgical) warrants the best outcomes remains open.
authors.affiliation: Medizinische Klinik I, Schwerpunkte Kardiologie, Angiologie, Pulmologie und Internistische Intensivmedizin, Krankenhaus Düren gGmbH, Roonstrasse 30, 52351 Düren, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Brandt
authors.forename: D C
authors.initials: DC
authors.lastname: Gulba
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D001145:Arrhythmias, Cardiac / Q000401:mortality / Q000503:physiopathology / Q000628:therapy*; D003327:Coronary Disease / Q000401:mortality / Q000503:physiopathology / Q000628:therapy*; D016757:Death, Sudden, Cardiac / Q000453:epidemiology / Q000517:prevention & control*; D004562:Electrocardiography; D005080:Exercise Test; D006801:Humans; D007473:Ion Channels / Q000502:physiology; D017202:Myocardial Ischemia / Q000401:mortality / Q000503:physiopathology / Q000628:therapy*; D009204:Myocardial Revascularization; D032383:Myocytes, Cardiac / Q000502:physiology; D011379:Prognosis; D018570:Risk Assessment
chemical_list: D007473:Ion Channels; D000255:Adenosine Triphosphate