title: Draft genome sequence of the sexually transmitted pathogen Trichomonas vaginalis.
abstract: We describe the genome sequence of the protist Trichomonas vaginalis, a sexually transmitted human pathogen. Repeats and transposable elements comprise about two-thirds of the approximately 160-megabase genome, reflecting a recent massive expansion of genetic material. This expansion, in conjunction with the shaping of metabolic pathways that likely transpired through lateral gene transfer from bacteria, and amplification of specific gene families implicated in pathogenesis and phagocytosis of host proteins may exemplify adaptations of the parasite during its transition to a urogenital environment. The genome sequence predicts previously unknown functions for the hydrogenosome, which support a common evolutionary origin of this unusual organelle with mitochondria.
authors.affiliation: Institute for Genomic Research, 9712 Medical Research Drive, Rockville, MD 20850, USA. jane.carlton@med.nyu.edu
authors.forename: Jane M
authors.initials: JM
authors.lastname: Carlton
authors.forename: Robert P
authors.initials: RP
authors.lastname: Hirt
authors.forename: Joana C
authors.initials: JC
authors.lastname: Silva
authors.forename: Arthur L
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authors.lastname: Delcher
authors.forename: Michael
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authors.lastname: Schatz
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authors.lastname: Zhao
authors.forename: Jennifer R
authors.initials: JR
authors.lastname: Wortman
authors.forename: Shelby L
authors.initials: SL
authors.lastname: Bidwell
authors.forename: U Cecilia M
authors.initials: UC
authors.lastname: Alsmark
authors.forename: Sébastien
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authors.lastname: Besteiro
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authors.initials: T
authors.lastname: Sicheritz-Ponten
authors.forename: Christophe J
authors.initials: CJ
authors.lastname: Noel
authors.forename: Joel B
authors.initials: JB
authors.lastname: Dacks
authors.forename: Peter G
authors.initials: PG
authors.lastname: Foster
authors.forename: Cedric
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authors.lastname: Simillion
authors.forename: Yves
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authors.lastname: Van de Peer
authors.forename: Diego
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authors.lastname: Miranda-Saavedra
authors.forename: Geoffrey J
authors.initials: GJ
authors.lastname: Barton
authors.forename: Gareth D
authors.initials: GD
authors.lastname: Westrop
authors.forename: Sylke
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authors.lastname: Müller
authors.forename: Daniele
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authors.lastname: Dessi
authors.forename: Pier Luigi
authors.initials: PL
authors.lastname: Fiori
authors.forename: Qinghu
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authors.lastname: Paulsen
authors.forename: Hanbang
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authors.lastname: Zhang
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authors.initials: FD
authors.lastname: Bastida-Corcuera
authors.forename: Augusto
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authors.lastname: Simoes-Barbosa
authors.forename: Mark T
authors.initials: MT
authors.lastname: Brown
authors.forename: Richard D
authors.initials: RD
authors.lastname: Hayes
authors.forename: Mandira
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authors.lastname: Mukherjee
authors.forename: Cheryl Y
authors.initials: CY
authors.lastname: Okumura
authors.forename: Rachel
authors.initials: R
authors.lastname: Schneider
authors.forename: Alias J
authors.initials: AJ
authors.lastname: Smith
authors.forename: Stepanka
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authors.lastname: Vanacova
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authors.lastname: Villalvazo
authors.forename: Brian J
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authors.lastname: Haas
authors.forename: Mihaela
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authors.lastname: Pertea
authors.forename: Tamara V
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authors.lastname: Feldblyum
authors.forename: Terry R
authors.initials: TR
authors.lastname: Utterback
authors.forename: Chung-Li
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authors.lastname: Shu
authors.forename: Kazutoyo
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authors.lastname: Osoegawa
authors.forename: Pieter J
authors.initials: PJ
authors.lastname: de Jong
authors.forename: Ivan
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authors.lastname: Hrdy
authors.forename: Lenka
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authors.lastname: Horvathova
authors.forename: Zuzana
authors.initials: Z
authors.lastname: Zubacova
authors.forename: Pavel
authors.initials: P
authors.lastname: Dolezal
authors.forename: Shehre-Banoo
authors.initials: SB
authors.lastname: Malik
authors.forename: John M
authors.initials: JM
authors.lastname: Logsdon
authors.forename: Katrin
authors.initials: K
authors.lastname: Henze
authors.forename: Arti
authors.initials: A
authors.lastname: Gupta
authors.forename: Ching C
authors.initials: CC
authors.lastname: Wang
authors.forename: Rebecca L
authors.initials: RL
authors.lastname: Dunne
authors.forename: Jacqueline A
authors.initials: JA
authors.lastname: Upcroft
authors.forename: Peter
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authors.lastname: Upcroft
authors.forename: Owen
authors.initials: O
authors.lastname: White
authors.forename: Steven L
authors.initials: SL
authors.lastname: Salzberg
authors.forename: Petrus
authors.initials: P
authors.lastname: Tang
authors.forename: Cheng-Hsun
authors.initials: CH
authors.lastname: Chiu
authors.forename: Ying-Shiung
authors.initials: YS
authors.lastname: Lee
authors.forename: T Martin
authors.initials: TM
authors.lastname: Embley
authors.forename: Graham H
authors.initials: GH
authors.lastname: Coombs
authors.forename: Jeremy C
authors.initials: JC
authors.lastname: Mottram
authors.forename: Jan
authors.initials: J
authors.lastname: Tachezy
authors.forename: Claire M
authors.initials: CM
authors.lastname: Fraser-Liggett
authors.forename: Patricia J
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authors.lastname: Johnson
mesh_terms: D000818:Animals; D001692:Biological Transport / Q000235:genetics; D004251:DNA Transposable Elements; D016054:DNA, Protozoan / Q000235:genetics; D022761:Gene Transfer, Horizontal; D017125:Genes, Protozoan; D018503:Genome, Protozoan; D006801:Humans; D006859:Hydrogen / Q000378:metabolism; D053858:Metabolic Networks and Pathways / Q000235:genetics; D008969:Molecular Sequence Data; D005810:Multigene Family; D015388:Organelles / Q000378:metabolism; D018384:Oxidative Stress / Q000235:genetics; D010447:Peptide Hydrolases / Q000235:genetics / Q000378:metabolism; D015800:Protozoan Proteins / Q000235:genetics / Q000502:physiology; D012323:RNA Processing, Post-Transcriptional; D012091:Repetitive Sequences, Nucleic Acid; D017422:Sequence Analysis, DNA; D012749:Sexually Transmitted Diseases / Q000469:parasitology; D014245:Trichomonas Infections / Q000469:parasitology / Q000635:transmission; D014246:Trichomonas vaginalis / Q000166:cytology / Q000235:genetics* / Q000378:metabolism / Q000472:pathogenicity
chemical_list: D004251:DNA Transposable Elements; D016054:DNA, Protozoan; D015800:Protozoan Proteins; D006859:Hydrogen; D010447:Peptide Hydrolases