The causation of childhood leukemia: a paradox of progress?
Treatments, mostly combination chemotherapies, have been remarkably effective in managing many childhood leukemia cases. However, childhood leukemia is a heterogeneous (mixed) disease originating from different cell lineages and with distinct mechanisms. Authors described hypotheses of "population mixing" and "delayed infection" as causes of childhood leukemia.
Greaves
Mel
M
Section of Haemato-Oncology, The Institute of Cancer Research, Chester Beatty Laboratories, 237 Fulham Road, London SW3 6JB, UK.
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D004781:Environmental Exposure; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007239:Infections / Q000150:complications; D007938:Leukemia / Q000453:epidemiology / Q000209:etiology* / Q000235:genetics / Q000378:metabolism*; D008954:Models, Biological