Cerebrospinal fluid anti-SSA autoantibodies in primary Sjogren's syndrome with central nervous system involvement.
BACKGROUND
Central nervous system involvement in primary Sjogren's syndrome is a matter of controversy, and its diagnosis remains difficult.


METHODS
We report 3 patients with primary Sjogren's syndrome and central nervous system involvement in whom we assessed intrathecal immunoglobulin G synthesis and the presence of cerebrospinal fluid anti-SSA and anti-SSB autoantibodies.


RESULTS
We found intrathecal immunoglobulin G synthesis and presence of cerebrospinal fluid anti-SSA autoantibodies in all patients, with demonstration for the first time of specific anti-SSA autoantibody intrathecal synthesis in 2 patients.


CONCLUSIONS
We suggest that cerebrospinal fluid anti-SSA autoantibodies could serve as a biomarker for Sjogren's-syndrome-related central nervous system involvement.
Mégevand
Pierre
P
Service of Neurology, Department of Clinical Neuroscience and Dermatology, Geneva University Hospital and School of Medicine, Geneva, Switzerland. pierre.megevand@medecine.unige.ch
Chizzolini
Carlo
C
Chofflon
Michel
M
Roux-Lombard
Pascale
P
Lalive
Patrice H
PH
Picard
Fabienne
F
D000974:Antibodies, Antinuclear / Q000097:blood / Q000134:cerebrospinal fluid; D001323:Autoantibodies / Q000097:blood / Q000134:cerebrospinal fluid*; D002490:Central Nervous System / Q000503:physiopathology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000134:cerebrospinal fluid; D008875:Middle Aged; D009069:Movement Disorders / Q000209:etiology*; D012859:Sjogren's Syndrome / Q000134:cerebrospinal fluid / Q000276:immunology* / Q000473:pathology / Q000503:physiopathology
D000974:Antibodies, Antinuclear; D001323:Autoantibodies; D007074:Immunoglobulin G; C035356:SS-A antibodies; C035357:SS-B antibodies