title: Expression of human telomerase reverse transcriptase and cyclin-D1 in olfactory neuroblastoma.
abstract: Olfactory neuroblastoma is an uncommon neoplasm. Typically, these tumors are indolent with long-standing symptomatology, but the fact that the lesions are indeed malignant has been proven by the repeated demonstration that they can metastasize to distant organs. Suitable prognostic factors are lacking and therapeutic strategy still remains controversial. Expression of human telomerase reverse transcriptase (hTERT) is associated with most human malignancies and high levels have been correlated with poor prognosis in many cancers. In comparison, overexpression of cyclin-D1 occurs in several malignancies and has been associated with aggressive tumor behavior and poorer prognosis. In this study, we collected 16 olfactory neuroblastomas from the Kaohsiung Medical University Hospital. The aim was to investigate the value of immunoexpression of hTERT and cyclin-D1 in correlation with clinicopathologic features of olfactory neuroblastoma. Low and high cyclin-D1 expression was found in 6 and 10 cases, respectively. For hTERT, low and high protein expression was detected in 5 and 11 tumors, respectively. Cyclin-D1 expression was not correlated with selected parameters. However, high hTERT expression was significantly correlated with high Kadish stage. In conclusion, high hTERT expression can be considered a potential indicator of aggressive olfactory neuroblastoma.
authors.affiliation: Department of Pathology, Kaohsiung Medical University, Kaohsiung City, Taiwan.
authors.forename: Sheng-Lan
authors.initials: SL
authors.lastname: Wang
authors.forename: Wan-Tzu
authors.initials: WT
authors.lastname: Chen
authors.forename: Shau-Hsuan
authors.initials: SH
authors.lastname: Li
authors.forename: Sung-Wei
authors.initials: SW
authors.lastname: Li
authors.forename: Sheau-Fang
authors.initials: SF
authors.lastname: Yang
authors.forename: Chee-Yin
authors.initials: CY
authors.lastname: Chai
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis / Q000235:genetics / Q000378:metabolism; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000201:enzymology / Q000473:pathology; D056741:Cyclin D; D016213:Cyclins / Q000378:metabolism*; D006801:Humans; D009447:Neuroblastoma / Q000175:diagnosis* / Q000201:enzymology / Q000473:pathology; D009669:Nose Neoplasms / Q000175:diagnosis* / Q000473:pathology; D012333:RNA, Messenger / Q000235:genetics; D012334:RNA, Neoplasm / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction; D019098:Telomerase / Q000032:analysis / Q000235:genetics / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; D056741:Cyclin D; D016213:Cyclins; D012333:RNA, Messenger; D012334:RNA, Neoplasm; C509186:TERT protein, human; D019098:Telomerase