Structure-activity relationship study of the bacterial actin-like protein MreB inhibitors: effects of substitution of benzyl group in S-benzylisothiourea.
We comprehensively investigated the effects of substitution of the benzyl group in S-benzylisothiourea derivatives on antibacterial activity, because we found previously that some substitutions enhanced it. A 2,4-Cl2-derivative was found to be the most effective compound, it was stronger than the original one in Gram-negative rod shaped-bacteria such as Escherichia coli and Salmonella typhimurium.
Iwai
Noritaka
N
Department of Bioengineering, Tokyo Institute of Technology, Japan. niwai@bio.titech.ac.jp
Fujii
Takuya
T
Nagura
Hirokatsu
H
Wachi
Masaaki
M
Kitazume
Tomoya
T
D000199:Actins / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000378:metabolism*; D001426:Bacterial Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D004926:Escherichia coli / Q000187:drug effects / Q000378:metabolism; D015394:Molecular Structure; D012486:Salmonella typhimurium / Q000187:drug effects / Q000378:metabolism; D013329:Structure-Activity Relationship; D013890:Thiourea / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology
D000199:Actins; D001426:Bacterial Proteins; D013890:Thiourea