Metabolism of methenolone acetate in a veal calf.
The use of anabolic steroids has been banned in the European Union since 1981. In this study, the metabolism of the anabolic steroid methenolone acetate, was investigated in a male veal calf. After daily oral administration of methenolone acetate, three main metabolites were detected in both urine and faeces samples. Among these metabolites, alpha-methenolone was apparently the main one, but 1-methyl-5alpha-androstan-3,17-diol and 3alpha-hydroxy-1-methyl-5alpha-androstan-17-one were also observed. The parent compound was still detectable in faeces. As a consequence, abuse of methenolone acetate as growth promoter can be monitored by analysing urine and faeces samples. A few days after the last treatment, however, no metabolites were observed. Alpha-methenolone was detectable in urine until 5 days after the last treatment, but in faeces no metabolites were detectable after 3 days.
Van Hoof
N
N
Research Group Veterinary Public Health and Zoonoses, Department of Veterinary Public Health and Food Safety, Laboratory of Chemical Analysis, Ghent University, Merelbeke, Belgium.
Courtheyn
D
D
Gillis
W
W
Van Hende
J
J
Van Peteghem
C
C
Van de Wiele
M
M
Poelmans
S
S
Noppe
H
H
Van Poucke
C
C
Cobbaert
E
E
Vanthemse
P
P
De Brabander
H F
HF
D045930:Anabolic Agents / Q000378:metabolism* / Q000652:urine; D000818:Animals; D002417:Cattle / Q000378:metabolism*; D005243:Feces / Q000737:chemistry; D008401:Gas Chromatography-Mass Spectrometry / Q000662:veterinary; D008297:Male; D008710:Methenolone / Q000031:analogs & derivatives* / Q000378:metabolism / Q000652:urine
D045930:Anabolic Agents; D008710:Methenolone; C033244:methenolone acetate