[Chemical constituents in root of Zanthoxylum nitidum].
OBJECTIVE
To study the chemical constituents of Zanthoxylum nitidum.


METHODS
Column chromatography on Silica gel and Sephadex LH - 20, and recrystallization were applied for the isolation and purification of the constituents. The structures were elucidated on the basis of spectral analysis, chemical evidences and by comparison with the data reported in literature.


RESULTS
From the CHCl3 fraction and n-butanol fraction of the EtOH extract of the roots of Z. nitidum, 10 compounds were isolated and identified as 2, 4-dihydroxypyrimidine (1), syringic acid (2) , 2, 6-dimethoxy-1, 4-benzoquinone (3) , 4-hydroxybenzoic acid (4), ethylparaben (5), (Z)-3-(2, 3, 4-trimethoxyphenyl) acrylic acid (6), 5, 6, 7-trimethoxycoumarin (7), stigmast-9 (11) -en-3-ol (8), daucosterol (9), beta-sitosterol (10).


CONCLUSIONS
Compounds 1-9 were isolated and identified from the roots of Z. nitidum for the first time. Furthermore, we note here the first isolation of compound 6 as a natural product.
Hu
Jiang
J
School of Pharmacy, Second Military Medical University, Shanghai 200433, China.
Zhang
Wei-Dong
WD
Liu
Run-Hui
RH
Zhang
Chuan
C
Shen
Yun-Heng
YH
Xu
Xi-Ke
XK
Liang
Ming-Jin
MJ
Li
Hui-Liang
HL
D000179:Acrylates / Q000737:chemistry / Q000302:isolation & purification*; D005707:Gallic Acid / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification; D010226:Parabens / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D032106:Zanthoxylum / Q000737:chemistry*
C524213:3-(2,3,4-trimethoxyphenyl)acrylic acid; D000179:Acrylates; D010226:Parabens; D005707:Gallic Acid; C001945:syringic acid; C038193:4-hydroxybenzoic acid