title: Biological profile of new apoptotic agents based on 2,4-pyrido[2,3-d]pyrimidine derivatives.
abstract: In order to obtain less toxic antitumoral compounds we have looked for novel compounds with anticancer activity based on proapoptotic mechanisms. The compounds studied in this work are derivatives of bicyclic aromatic systems like pyrido[2,3-d]pyrimidines. The potential antitumoral activity of the compounds was evaluated in vitro by examining their cytotoxic effects against human breast, colon, and bladder cancer lines (MD-MBA-231, HT-29, and T-24). The data indicate that HC-6 is a potent anticancer drug showing dose-dependent cytostatic and proapoptotic effects through activation of two different signaling pathways namely a pathway leading to cell cycle arrest and a transcription-independent route leading to rapid apoptosis.
authors.affiliation: Laboratorio de Farmacogenómica, Area de Oncología, Centro de Investigación Médica Aplicada, Pamplona, Spain. lcorver@alumni.unav.es
authors.forename: Lucía
authors.initials: L
authors.lastname: Cordeu
authors.forename: Elena
authors.initials: E
authors.lastname: Cubedo
authors.forename: Eva
authors.initials: E
authors.lastname: Bandrés
authors.forename: Amaia
authors.initials: A
authors.lastname: Rebollo
authors.forename: Xabi
authors.initials: X
authors.lastname: Sáenz
authors.forename: Hector
authors.initials: H
authors.lastname: Chozas
authors.forename: Ma
authors.initials: M
authors.lastname: Victoria Domínguez
authors.forename: Mikel
authors.initials: M
authors.lastname: Echeverría
authors.forename: Beatriz
authors.initials: B
authors.lastname: Mendivil
authors.forename: Carmen
authors.initials: C
authors.lastname: Sanmartin
authors.forename: Juan Antonio
authors.initials: JA
authors.lastname: Palop
authors.forename: María
authors.initials: M
authors.lastname: Font
authors.forename: Jesús
authors.initials: J
authors.lastname: García-Foncillas
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects*; D001943:Breast Neoplasms / Q000188:drug therapy / Q000473:pathology; D002453:Cell Cycle / Q000187:drug effects; D045744:Cell Line, Tumor; D003110:Colonic Neoplasms / Q000188:drug therapy / Q000473:pathology; D004305:Dose-Response Relationship, Drug; D006801:Humans; D011743:Pyrimidines / Q000737:chemistry* / Q000494:pharmacology*; D015398:Signal Transduction / Q000187:drug effects; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy / Q000473:pathology
chemical_list: D000970:Antineoplastic Agents; D011743:Pyrimidines