title: In vitro reactivity of factor VIII inhibitors with von Willebrand factor in different commercial factor VIII concentrates.
abstract: A relevant aspect in the treatment of patients with hemophilia A (HA) presenting inhibitor against factor VIII (FVIII) is the different antigenicity of FVIII used for replacement therapy. The aim of the study was to assess the effect of different products, with variable von Willebrand factor (vWF) concentration, in preventing the binding of inhibitor to FVIII. The reactivity of inhibitors from plasma of 18 patients with HA versus three commercial concentrates containing different amounts of vWF was compared. The results show that increasing amounts of vWF might have a protective effect on the transfused FVIII inactivation.
authors.affiliation: Haemophilia Centre and Regional Blood Disease Centre, Castelfranco Veneto Hospital, Azienda ULSS 8, Regione Veneto, Italy. gtagariello@ulssasolo.ven.it
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Tagariello
authors.forename: Daniela
authors.initials: D
authors.lastname: Zanotto
authors.forename: Paolo
authors.initials: P
authors.lastname: Radossi
authors.forename: Roberto
authors.initials: R
authors.lastname: Sartori
authors.forename: Donata
authors.initials: D
authors.lastname: Belvini
authors.forename: Roberta
authors.initials: R
authors.lastname: Salviato
mesh_terms: D000328:Adult; D001688:Biological Products / Q000037:antagonists & inhibitors / Q000737:chemistry* / Q000276:immunology; D019774:Blood Coagulation Factor Inhibitors / Q000097:blood / Q000737:chemistry* / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D005169:Factor VIII / Q000037:antagonists & inhibitors / Q000737:chemistry* / Q000235:genetics; D006467:Hemophilia A / Q000097:blood* / Q000188:drug therapy / Q000276:immunology; D006801:Humans; D007223:Infant; D008875:Middle Aged; D009154:Mutation; D013997:Time Factors; D014841:von Willebrand Factor / Q000032:analysis / Q000737:chemistry*
chemical_list: D001688:Biological Products; D019774:Blood Coagulation Factor Inhibitors; D014841:von Willebrand Factor; D005169:Factor VIII