title: Effect of weight loss on the postprandial response to high-fat and high-carbohydrate meals in obese women.
abstract: OBJECTIVE
  To assess the effect of weight loss on the plasma lipid and remnant-like lipoprotein cholesterol (RLPc) response to a high-fat or a high-carbohydrate meal in a population of obese women.
  
  
  METHODS
  Nutritional intervention study.
  
  
  METHODS
  Sixteen obese women (mean body mass index (BMI): 37.6+/-5 kg/m(2)).
  
  
  METHODS
  Subjects were asked to follow an energy-restricted diet (800 kcal/day) for 7 weeks, followed by a 1-week maintenance diet. Before and after weight loss, each participant was given (in random order) two iso-energetic meals containing either 80% fat and 20% protein (the high-fat meal) or 80% carbohydrate and 20% protein (the high-carbohydrate meal). Blood samples were collected over the following 10-h period. A two-way analysis of variance with repeated measures was used to assess the effect of the meal and postprandial time on biological variables and postprandial responses (notably RLPc levels).
  
  
  RESULTS
  Weight loss was associated with a significant decrease in fasting triglyceride (P=0.0102), cholesterol (P<0.0001), low-density lipoprotein cholesterol (P=0.0003), high-density lipoprotein-cholesterol (P=0.0009) and RLPc (P=0.0015) levels. The triglyceride response to the high-fat meal was less intense after weight reduction than before (interaction P<0.002). This effect persisted after adjustment on baseline triglyceride levels. The triglyceride response to the high-carbohydrate meal was biphasic (i.e. with two peaks, 1 and 6 h after carbohydrate intake). After adjustment on baseline values, weight reduction was associated with a trend towards a reduction in the magnitude of the second triglyceride peak (interaction P<0.054). In contrast, there was no difference in postprandial RLPc responses before and after weight loss, again after adjustment on baseline levels.
  
  
  CONCLUSIONS
  Our data suggest that weight loss preferentially affects postprandial triglyceride metabolism.
authors.affiliation: Service d'Epidémiologie et Santé Publique, Institut Pasteur de Lille, INSERM, U744, Lille, Cedex, France. jean.dallongeville@pasteur-lille.fr
authors.forename: J
authors.initials: J
authors.lastname: Dallongeville
authors.forename: E
authors.initials: E
authors.lastname: Gruson
authors.forename: G
authors.initials: G
authors.lastname: Dallinga-Thie
authors.forename: M
authors.initials: M
authors.lastname: Pigeyre
authors.forename: S
authors.initials: S
authors.lastname: Gomila
authors.forename: M
authors.initials: M
authors.lastname: Romon
mesh_terms: D000704:Analysis of Variance; D019540:Area Under Curve; D015992:Body Mass Index; D008076:Cholesterol, HDL / Q000097:blood / Q000378:metabolism; D008078:Cholesterol, LDL / Q000097:blood / Q000378:metabolism; D004040:Dietary Carbohydrates / Q000008:administration & dosage* / Q000378:metabolism; D004041:Dietary Fats / Q000008:administration & dosage* / Q000378:metabolism; D005260:Female; D006801:Humans; D050356:Lipid Metabolism; D009765:Obesity / Q000097:blood / Q000178:diet therapy / Q000378:metabolism*; D019518:Postprandial Period; D014280:Triglycerides / Q000097:blood* / Q000378:metabolism; D015431:Weight Loss / Q000502:physiology
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D004040:Dietary Carbohydrates; D004041:Dietary Fats; D014280:Triglycerides