Metallo-beta-lactamases as emerging resistance determinants in Gram-negative pathogens: open issues.
The rapid spread of acquired metallo-beta-lactamases (MBLs) among major Gram-negative pathogens is a matter of particular concern worldwide and primarily in Europe, one of first continents where the emergence of acquired MBLs has been reported and possibly the geographical area where the increasing diversity of these enzymes and the number of bacterial species affected are most impressive. This spread has not been paralleled by accuracy/standardisation of detection methods, completeness of epidemiological knowledge or a clear understanding of what MBL production entails in terms of clinical impact, hospital infection control and antimicrobial chemotherapy. A number of European experts in the field met to review the current knowledge on this phenomenon, to point out open issues and to reinforce and relate to one another the existing activities set forth by research institutes, scientific societies and European Union-driven networks.
Cornaglia
Giuseppe
G
Department of Pathology, University of Verona, Italy. giuseppe.cornaglia@univr.it
Akova
Murat
M
Amicosante
Gianfranco
G
Cantón
Rafael
R
Cauda
Roberto
R
Docquier
Jean-Denis
JD
Edelstein
Mikhail
M
Frère
Jean-Marie
JM
Fuzi
Miklós
M
Galleni
Moreno
M
Giamarellou
Helen
H
Gniadkowski
Marek
M
Koncan
Raffaella
R
Libisch
Balázs
B
Luzzaro
Francesco
F
Miriagou
Vivi
V
Navarro
Ferran
F
Nordmann
Patrice
P
Pagani
Laura
L
Peixe
Luisa
L
Poirel
Laurent
L
Souli
Maria
M
Tacconelli
Evelina
E
Vatopoulos
Alkiviadis
A
Rossolini
Gian Maria
GM
D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D024901:Drug Resistance, Multiple, Bacterial; D005062:European Union; D006090:Gram-Negative Bacteria / Q000145:classification / Q000187:drug effects / Q000302:isolation & purification* / Q000502:physiology*; D016905:Gram-Negative Bacterial Infections / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology* / Q000517:prevention & control; D006801:Humans; D008826:Microbial Sensitivity Tests; D018440:beta-Lactam Resistance; D001618:beta-Lactamases / Q000187:drug effects / Q000502:physiology*
D000900:Anti-Bacterial Agents; D001618:beta-Lactamases