Transient hypoxia and downregulation of circulating prohepcidin concentrations in healthy young men.
To determine the impact of acute hypoxia on prohepcidin concentrations in humans, we measured concentrations of this peptide in serum collected during and after a transient period (30 min) of hypoxia and during normoxia. Prohepcidin concentrations were significantly lower 150 min after the end of hypoxia than after normoxia (p=0.028).
Benedict
Christian
C
Ghio
Andrew J
AJ
Gehring
Hartmut
H
Schultes
Bernd
B
Peters
Achim
A
Oltmanns
Kerstin M
KM
D000328:Adult; D023181:Antimicrobial Cationic Peptides / Q000097:blood*; D015536:Down-Regulation; D064451:Hepcidins; D006706:Homeostasis; D006801:Humans; D000860:Hypoxia; D007501:Iron / Q000097:blood; D010100:Oxygen / Q000378:metabolism; D010455:Peptides / Q000737:chemistry; D011498:Protein Precursors / Q000097:blood*; D013997:Time Factors
D023181:Antimicrobial Cationic Peptides; D064451:Hepcidins; D010455:Peptides; D011498:Protein Precursors; D007501:Iron; D010100:Oxygen