Green tea [Camellia sinensis (L.) O. Kuntze] extract reverses the despair behaviour in reserpinised and diabetic mice.
Green tea (C. sinensis) extract (GTE) dose dependently produced reversal of despair in normal, reserpinised and diabetic mice, thereby demonstrating an antidepressant effect. Although the exact mechanism is yet to be explored, the possible inhibition of catechol-o-methyl transferase and monoamine oxidase enzymes may be responsible for antidepressant activity of GTE.
Singal
Anjali
A
Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160 014, India.
Tirkey
Naveen
N
Muragundla
Anjaneyulu
A
Chopra
Kanwaljit
K
D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects; D028241:Camellia sinensis / Q000737:chemistry*; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000523:psychology*; D006185:Habituation, Psychophysiologic / Q000187:drug effects; D006380:Helplessness, Learned; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D008517:Phytotherapy / Q000379:methods; D010936:Plant Extracts / Q000494:pharmacology*; D012110:Reserpine / Q000494:pharmacology*; D013311:Streptozocin; D013550:Swimming
D000928:Antidepressive Agents; D010936:Plant Extracts; D013311:Streptozocin; D012110:Reserpine