Evaluation of the efficacy of triple therapy regimen for Helicobacter pylori eradication in gastrectomized patients with gastric adenocarcinoma.
BACKGROUND
The cause of cancer in the gastric stump is multifactorial, and Helicobacter pylori is one of these factors. Its eradication has been recommended; however, there are few studies about of H. pylori eradication in gastrectomized patients.


METHODS
Twenty gastrectomized patients with gastric adenocarcinoma and Roux-en-Y reconstruction (study group) infected by H. pylori were compared with nongastrectomized patients (control group) also infected by H. pylori. The presence of H. pylori was determined by the ultra-quick urease test and from a histological sample obtained by endoscopy. Both groups received the same triple therapy regimen.


RESULTS
The rate of eradication of H. pylori in the study group was 90% and in the control group, it was 85%. Sex, age, and postoperative time did not influence the rate of eradication.


CONCLUSIONS
There were no differences in the efficacy of H. pylori eradication between the two groups; therefore, the triple therapy regimen is effective for the eradication of H. pylori in gastrectomized patients with a Roux-en-Y reconstruction.
Bertoli Neto
Jose Luiz
JL
Department of Surgery, Fellow of Universidade Federal de São Paulo -- Escola-Paulista de Medicina, São Paulo, Brazil.
Lourenço
Laercio Gomes
LG
Bertoli
Cícero Fernando
CF
Ulbrich
Fábio Samsonowski
FS
Sabbi
Antoninho Ricardo
AR
Bueno
Alexandre Galvão
AG
D053799:2-Pyridinylmethylsulfinylbenzimidazoles / Q000627:therapeutic use; D000230:Adenocarcinoma / Q000188:drug therapy* / Q000382:microbiology / Q000601:surgery; D000328:Adult; D000368:Aged; D000658:Amoxicillin / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D016022:Case-Control Studies; D017291:Clarithromycin / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D005743:Gastrectomy; D016481:Helicobacter Infections / Q000188:drug therapy* / Q000382:microbiology / Q000601:surgery; D016480:Helicobacter pylori; D006801:Humans; D064747:Lansoprazole; D008297:Male; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000382:microbiology / Q000601:surgery
D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D000900:Anti-Bacterial Agents; D000897:Anti-Ulcer Agents; D064747:Lansoprazole; D000658:Amoxicillin; D017291:Clarithromycin