[Effectiveness and safety of the treatment of menopausal syndrome with Cimicifuga racemosa dry extract].
OBJECTIVE
Phytoestrogens could be an alternative method of the treatment of menopausal syndrome in women with contraindications to hormonal replacement therapy.


METHODS
The aim of the study was to evaluate efficacy and safety of the therapy with Cimicifuga racemosa dry extract.


METHODS
Twenty women aged mean 52.4 +/- 4.9 years with climacteric syndrome were treated with Cimicifuga racemosa dry extract in a dose of 40 mg a day during 6 months. Kupperman's Index, biochemical parameters and hormonal profile were estimated before and after 3 and 6 months of the therapy.


RESULTS
Mean values of Kuppermen's Index were decreased from 30.2 +/- 5.7 points before the therapy to 8.5 +/- 6.3 points after 3 months and to 2.6 +/- 2.1 points after 6 months of the therapy (p < 0.05). No statistical differences in biochemical parameters' concentrations and hormonal profile were observed.


CONCLUSIONS
Cimicifuga racemosa dry extract was an effective and safe therapy of climacteric women with contraindications to hormonal replacement therapy.
Radowicki
Stanisław
S
Klinika Endokrynologii Ginekologicznej Akademii Medycznej w Warszawie.
Skórzewska
Katarzyna
K
Rudnicka
Ewa
E
Szlendak-Sauer
Katarzyna
K
Wierzba
Waldemar
W
D031885:Cimicifuga; D004305:Dose-Response Relationship, Drug; D005260:Female; D019584:Hot Flashes / Q000188:drug therapy*; D006801:Humans; D008593:Menopause / Q000187:drug effects*; D008875:Middle Aged; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage; D011044:Poland; D011446:Prospective Studies; D018709:Statistics, Nonparametric; D016896:Treatment Outcome; D016387:Women's Health
D010936:Plant Extracts