A role of a lymphocyte tryptase, granzyme A, in experimental ulcerative colitis.
In the large-intestinal mucosae of rats orally administered dextran sulfate sodium, which induces an enteritis resembling ulcerative colitis (UC), the activity for granzyme A, a lymphocyte tryptase, increased at an earlier stage than that at which UC markers (growth-regulated gene product/cytokine-induced neutrophil chemoattractant-1 and caspase-3) increased. This suggests involvement of the enzyme in the exacerbation and perpetuation of enteritis.
Hirayasu
Hirofumi
H
Laboratory of Nutrition Chemistry, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Japan.
Yoshikawa
Yumiko
Y
Tsuzuki
Satoshi
S
Fushiki
Tohru
T
D000818:Animals; D053148:Caspase 3 / Q000378:metabolism; D002478:Cells, Cultured; D054360:Chemokine CXCL1; D019743:Chemokines, CXC / Q000378:metabolism; D003093:Colitis, Ulcerative / Q000139:chemically induced / Q000201:enzymology*; D016264:Dextran Sulfate / Q000494:pharmacology; D004195:Disease Models, Animal; D004789:Enzyme Activation / Q000187:drug effects; D053804:Granzymes / Q000378:metabolism*; D008214:Lymphocytes / Q000187:drug effects / Q000201:enzymology; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D053802:Tryptases / Q000378:metabolism*
D054360:Chemokine CXCL1; D019743:Chemokines, CXC; C513297:Cxcl1 protein, rat; D016264:Dextran Sulfate; D053804:Granzymes; D053802:Tryptases; D053148:Caspase 3