Chemokine signaling pathways in corneal fibroblasts.
Chemokines act as leukocyte chemoattractants with fine specificity for individual leukocyte types. Chemokine activation in infectious and inflammatory conditions of the cornea has been well described and is thought to result from rapid activation of intracellular signaling cascades within corneal cells. Keratocytes, the resident cells of the corneal stroma, capably express a diverse array of chemokine family members. We describe the role of chemokines in corneal inflammation in both human disease and experimental animal models. Understanding the precise molecular signaling mechanisms for regulation of chemokine expression will be integral to the design of strategies for the reduction of detrimental corneal inflammation.
Nour
May
M
Molecular Pathogenesis of Eye Infection Research Center, Dean A. McGee Eye Institute, Department of Ophthalmology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
Chodosh
James
J