title: A dynamic model for assessing universal Hepatitis A vaccination in Canada.
abstract: Vaccination against Hepatitis A virus (HAV) in Canada is currently targeted toward high-risk groups. However, universal vaccination has been adopted in several other countries with a similar disease burden. Here we develop an age-structured compartmental model of HAV transmission and vaccination in Canada to assess potential universal vaccination strategies. The model predicts that universal vaccination at age 1 (respectively 4, 9, 15), with phasing out of targeted vaccination, would reduce reported incidence by 60% (respectively 52, 36, 31%) and mortality attributable to HAV by 56% (respectively 45, 26, 25%), relative to continued targeted vaccination, over 80 years.
authors.affiliation: Department of Mathematics and Statistics, University of Guelph, Canada. cbauch@uoguelph.ca
authors.forename: C T
authors.initials: CT
authors.lastname: Bauch
authors.forename: Arni S R Srinivasa
authors.initials: AS
authors.lastname: Rao
authors.forename: B Z
authors.initials: BZ
authors.lastname: Pham
authors.forename: M
authors.initials: M
authors.lastname: Krahn
authors.forename: V
authors.initials: V
authors.lastname: Gilca
authors.forename: B
authors.initials: B
authors.lastname: Duval
authors.forename: M H
authors.initials: MH
authors.lastname: Chen
authors.forename: A C
authors.initials: AC
authors.lastname: Tricco
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002170:Canada; D002648:Child; D002675:Child, Preschool; D005544:Forecasting; D006506:Hepatitis A / Q000276:immunology / Q000517:prevention & control* / Q000635:transmission; D022362:Hepatitis A Vaccines / Q000276:immunology*; D006801:Humans; D017589:Immunization Programs / Q000379:methods*; D007115:Immunization Schedule; D007223:Infant; D007231:Infant, Newborn; D032541:Mass Vaccination / Q000379:methods*; D008875:Middle Aged; D015233:Models, Statistical
chemical_list: D022362:Hepatitis A Vaccines