title: Disruption of synaesthesia following TMS of the right posterior parietal cortex.
abstract: This study examines the role of four regions of the parietal lobe in grapheme-colour synaesthesia. TMS applied over a right parieto-occipital region disrupts performance on a synaesthetic priming task. TMS over the left parietal or a more anterior right parietal site did not have a reliable effect on synaesthesia even though one of the sites had been implicated in synaesthesia by previous fMRI studies. The same disruption is found for synaesthetes who experience colours in their "mind's eye" as well as those who project colours onto the inducing grapheme. This region may be important for binding graphemes and colours to different spatial reference frames.
authors.affiliation: Department of Psychology & Institute of Cognitive Neuroscience, University College London, UK.
authors.forename: Neil
authors.initials: N
authors.lastname: Muggleton
authors.forename: Elias
authors.initials: E
authors.lastname: Tsakanikos
authors.forename: Vincent
authors.initials: V
authors.lastname: Walsh
authors.forename: Jamie
authors.initials: J
authors.lastname: Ward
mesh_terms: D000328:Adult; D001931:Brain Mapping; D003118:Color Perception / Q000502:physiology; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D010296:Parietal Lobe / Q000473:pathology / Q000503:physiopathology / Q000528:radiation effects; D010468:Perceptual Disorders / Q000473:pathology* / Q000503:physiopathology; D050781:Transcranial Magnetic Stimulation / Q000379:methods*