[Hyper-IGE reactions in uveitis and their immunomodulation with cytokine-containing agents].
Examination of 73 patients with primary, active uveitis of various etiology established a high frequency (78%) of IgE hyperconcentrations particularly among patients with viral uveitis (95%) and in the presence of systemic diseases (65.2%). The correlations between IgE and some values of T, humoral immunity, and cytokines support the multiple factors of the immunopathogenesis of uveitis. Combined treatment with local instillations of autocytokines and superlymph provided a high immunomodulating effect. The established IgE hyperproduction in uveitis may be a reflection of either rapidly progressive allergy or an allergic background and serve as a pathogenetic rationale for the use of antihistamines and immunotherapy with cytokine-containing agents.
Teplinskaia
L E
LE
Filichkina
N S
NS
D000936:Antigen-Antibody Complex / Q000032:analysis; D016207:Cytokines / Q000008:administration & dosage / Q000627:therapeutic use*; D003627:Data Interpretation, Statistical; D004351:Drug Resistance; D006801:Humans; D007124:Immunoenzyme Techniques; D007073:Immunoglobulin E / Q000097:blood* / Q000276:immunology; D007155:Immunologic Factors / Q000008:administration & dosage / Q000627:therapeutic use*; D010726:Phosphodiesterase Inhibitors / Q000494:pharmacology; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology; D013806:Theophylline / Q000494:pharmacology; D014605:Uveitis / Q000188:drug therapy* / Q000209:etiology / Q000276:immunology* / Q000821:virology
D000936:Antigen-Antibody Complex; D016207:Cytokines; D007155:Immunologic Factors; D010726:Phosphodiesterase Inhibitors; D007073:Immunoglobulin E; D013806:Theophylline