Solution-phase parallel synthesis of 3,5,6-substituted indolin-2-ones.
A practical and efficient new parallel method has been developed for the synthesis of 3-substituted indolin-2-ones with a large variety of substituents at the 5- and 6-positions using 1,5-difluoro-2,4-dinitrobenzene. This 3,5,6-substituted indolin-2-one skeleton possesses three points of diversification and, thus, affords new opportunities for identification and optimization of leads in drug discovery.
Yang
Tian-Ming
TM
Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, 1 Xian Nong Tan Street, Beijing 100050, P. R. China.
Liu
Gang
G
D020650:Combinatorial Chemistry Techniques / Q000379:methods; D004139:Dinitrofluorobenzene / Q000031:analogs & derivatives* / Q000737:chemistry; D007211:Indoles / Q000138:chemical synthesis*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D015394:Molecular Structure
D007211:Indoles; D004139:Dinitrofluorobenzene; C002041:1,5-difluoro-2,4-dinitrobenzene