[The effects of vascular endothelial growth factor on dendritic cells in esophageal tumor tissue].
OBJECTIVE
To investigate the relationship between vascular endothelial growth factor (VEGF) and S100 protein positive dendritic cell (DC) in esophagelal tumor tissue.


METHODS
VEGF and S100 protein in 94 patients with esophageal carcinoma were detected by HRP Labelled streptavidin biotin(LSAB) immunohistochemical method.


RESULTS
Postive rate of VEGF in esophageal tumor tissues was 74.46%(70/94); and the later the clinical stage and the lower the differentiation level was the more VEGF was(r=0.864, 0.803, respectively; P<0.05); while the later the clinical stage and the lower the differentiation level was, the less number of S100(+) DCs existed (r=-0.763, -0.908, respectively; P<0.05). Furthermore, there was a reverse correlation between the expression of VEGF and S100(+) DC (r=-0.817, P<0.05).


CONCLUSIONS
There may be a reverse relationship between the expression of VEGF and S100(+) DC in esophageal tumor tissue, VEGF could decrease the number of S100(+) DC and impair the immunological function of the body.
Yang
Wen-feng
WF
Thoracic Surgery Department of Shandong Cancer Hospital, Jinan 250117, China.
Li
Dao-tang
DT
Li
Jing
J
Chen
Xu-xia
XX
Wagn
Shan-zheng
SZ
D000328:Adult; D000368:Aged; D003713:Dendritic Cells / Q000166:cytology / Q000378:metabolism*; D004938:Esophageal Neoplasms / Q000378:metabolism*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007150:Immunohistochemistry; D066298:In Vitro Techniques; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009418:S100 Proteins / Q000378:metabolism; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism*
D009418:S100 Proteins; D042461:Vascular Endothelial Growth Factor A