title: The development of CD-ring modified analogs of 1alpha,25-dihydroxyvitamin D.
abstract: During a 20-year collaboration the laboratories of UGent and KU Leuven have developed different series of Vitamin D analogs characterized by structural modifications in the central CD-ring system. Modifications have first involved the introduction of substituents at C11 and the epimerization at C14, and subsequently more drastic changes consisting in both ring deletion and enlargement relative to the natural CD-ring system. Lately, the focus has shifted towards the synthesis of analogs featuring a symmetrical CD-ring core. As an illustration two different series are presented.
authors.affiliation: Laboratory for Organic Synthesis, Department of Organic Chemistry, Ghent University, Krijgslaan 281 (S4), B-9000 Gent, Belgium. pierre.declercq@UGent.be
authors.forename: Pierre J
authors.initials: PJ
authors.lastname: De Clercq
authors.forename: Frederik
authors.initials: F
authors.lastname: De Buysser
authors.forename: Garrett
authors.initials: G
authors.lastname: Minne
authors.forename: Wim
authors.initials: W
authors.lastname: Schepens
authors.forename: Freek
authors.initials: F
authors.lastname: Vrielynck
authors.forename: Dirk
authors.initials: D
authors.lastname: Van Haver
authors.forename: Maurits
authors.initials: M
authors.lastname: Vandewalle
authors.forename: Annemieke
authors.initials: A
authors.lastname: Verstuyf
authors.forename: Roger
authors.initials: R
authors.lastname: Bouillon
mesh_terms: D002117:Calcitriol / Q000031:analogs & derivatives* / Q000096:biosynthesis / Q000138:chemical synthesis / Q000737:chemistry*; D015195:Drug Design; D006801:Humans; D015394:Molecular Structure
chemical_list: D002117:Calcitriol