title: Wilms' tumour 1 mutations are associated with FLT3-ITD and failure of standard induction chemotherapy in patients with normal karyotype AML.
authors.forename: K
authors.initials: K
authors.lastname: Summers
authors.forename: J
authors.initials: J
authors.lastname: Stevens
authors.forename: I
authors.initials: I
authors.lastname: Kakkas
authors.forename: M
authors.initials: M
authors.lastname: Smith
authors.forename: L L
authors.initials: LL
authors.lastname: Smith
authors.forename: F
authors.initials: F
authors.lastname: Macdougall
authors.forename: J
authors.initials: J
authors.lastname: Cavenagh
authors.forename: D
authors.initials: D
authors.lastname: Bonnet
authors.forename: B D
authors.initials: BD
authors.lastname: Young
authors.forename: T A
authors.initials: TA
authors.lastname: Lister
authors.forename: J
authors.initials: J
authors.lastname: Fitzgibbon
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D004252:DNA Mutational Analysis; D017931:DNA Primers; D019008:Drug Resistance, Neoplasm / Q000235:genetics*; D005091:Exons / Q000235:genetics; D005188:False Negative Reactions; D005260:Female; D016162:Genes, Wilms Tumor; D005838:Genotype; D006801:Humans; D007621:Karyotyping; D007951:Leukemia, Myeloid / Q000188:drug therapy / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D050505:Mutant Proteins / Q000235:genetics* / Q000502:physiology; D016133:Polymerase Chain Reaction; D017434:Protein Structure, Tertiary / Q000235:genetics; D020080:Tandem Repeat Sequences; D017211:Treatment Failure; D051941:fms-Like Tyrosine Kinase 3 / Q000235:genetics*
chemical_list: D017931:DNA Primers; D050505:Mutant Proteins; C497970:FLT3 protein, human; D051941:fms-Like Tyrosine Kinase 3