Cytostatic and antibacterial activity of some compounds isolated from several lamiaceae species from the canary islands.
A chemotherapeutic study has been carried out on thirteen products Eeleven diterpenes, one lignan, (+)-sesamin, and a coumarin, siderin] isolated from SALVIA and SIDERITIS species considered endemic to the Canarian flora. The data obtained suggest that some diterpenoid compounds show an interesting cytostatic activity, specially galdosol ( 6) with an ID (50) value of 0.5 microg/ml. These compounds also evidence a moderate antibacterial activity against Gram positive bacteria.
Darias
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V
Departamento de Farmacognosia y Farmacodinamia, Facultad de Farmacia, Universidad de La Laguna, Tenerife, Canary Islands, Spain.
Bravo
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L
Rabanal
R
R
Sánchez-Mateo
C C
CC
Martín-Herrera
D A
DA