Sequencing of a novel HLA-A allele, A*6836, showing a Bw4 epitope.
A novel A*6836 allele was completely characterized by sequence-based typing (SBT) in a cord blood sample from an Ecuadorian donor. A*6836 discloses six clustered amino acid residue changes at the alpha-1 domain, codons 76-83, regarding its closer A*680102 allele. Therefore, A*6836 would be a new human leukocyte antigen (HLA)-A molecule showing a Bw4-epitope.
Balas
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A
Departamento de Histocompatibilidad, Centro de Transfusión de la Comunidad de Madrid, Madrid, Spain. abalas.trans@salud.madrid.org
García-Sánchez
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Vicario
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JL
D000483:Alleles; D000939:Epitopes / Q000276:immunology / Q000302:isolation & purification*; D005312:Fetal Blood; D015234:HLA-A Antigens / Q000737:chemistry / Q000235:genetics* / Q000276:immunology*; D015235:HLA-B Antigens / Q000276:immunology / Q000302:isolation & purification*; D006801:Humans; D007231:Infant, Newborn; D017422:Sequence Analysis, DNA; D020539:Sequence Analysis, Protein
D000939:Epitopes; D015234:HLA-A Antigens; D015235:HLA-B Antigens; C042388:HLA-Bw4 antigen