title: Effect of royal jelly on bisphenol A-induced proliferation of human breast cancer cells.
abstract: Royal jelly is known as a functional food containing many useful minerals. In this study, we found an anti-environmental estrogen activity of royal jelly. Bisphenol A (BPA) is an environmental estrogen that stimulates proliferation of human breast cancer MCF-7 cells. Royal jelly inhibited the growth-promoting effect of BPA on MCF-7 cells, even though it did not affect the proliferation of cells in the absence of BPA. In addition, this inhibiting effect of royal jelly was heat-stable.
authors.affiliation: Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Japan. makorenu@agr.kyushu-u.ac.jp
authors.forename: Mako
authors.initials: M
authors.lastname: Nakaya
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Onda
authors.forename: Kyoko
authors.initials: K
authors.lastname: Sasaki
authors.forename: Akiko
authors.initials: A
authors.lastname: Yukiyoshi
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Tachibana
authors.forename: Koji
authors.initials: K
authors.lastname: Yamada
mesh_terms: D001559:Benzhydryl Compounds; D001943:Breast Neoplasms / Q000473:pathology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D005227:Fatty Acids / Q000494:pharmacology*; D006358:Hot Temperature; D006801:Humans; D010636:Phenols / Q000494:pharmacology*; D000099219:Royal Jelly; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D005227:Fatty Acids; D010636:Phenols; D000099219:Royal Jelly; C006780:bisphenol A; D000098826:Bisphenol A Compounds