title: [Successful treatment of intrapericardial administration of carboplatin following systemic chemotherapy in a case of advanced thymic cancer with cardiac tamponade].
abstract: A 72-year-old woman developed cardiac tamponade due to direct invasion of thymic cancer. Carboplatin was administered into the pericardial cavity two times with a total dose of 600 mg. Pericardial effusion disappeared without any toxicities. Following four cycles of systemic chemotherapy by carboplatin, doxorubicin, vincristine, cyclophosphamide (ADOC), partial response was obtained. She is alive 10 month after being given a diagnosis of cardiac tamponade. Intrapericardial administration of carboplatin is a useful therapy for control of pericardial effusion and chemosensitive cases should de identified among patients with thymic cancer.
authors.affiliation: First Department of Medicine, Shinshu University School of Medicine.
authors.forename: Mitsuyo
authors.initials: M
authors.lastname: Okada
authors.forename: Tomonobu
authors.initials: T
authors.lastname: Koizumi
authors.forename: Masanori
authors.initials: M
authors.lastname: Yasuo
authors.forename: Kenji
authors.initials: K
authors.lastname: Tsushima
authors.forename: Kazuhisa
authors.initials: K
authors.lastname: Urushihata
authors.forename: Shinji
authors.initials: S
authors.lastname: Yamaguchi
authors.forename: Masayuki
authors.initials: M
authors.lastname: Hanaoka
authors.forename: Keisaku
authors.initials: K
authors.lastname: Fujimoto
authors.forename: Keishi
authors.initials: K
authors.lastname: Kubo
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use*; D016190:Carboplatin / Q000008:administration & dosage*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000556:secondary; D002305:Cardiac Tamponade / Q000188:drug therapy* / Q000209:etiology; D002945:Cisplatin / Q000008:administration & dosage; D003520:Cyclophosphamide / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary; D016066:Pleural Effusion, Malignant / Q000188:drug therapy / Q000209:etiology; D012074:Remission Induction; D013953:Thymus Neoplasms / Q000188:drug therapy* / Q000473:pathology; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D016190:Carboplatin; D002945:Cisplatin