title: [The evaluation criterions about Caco-2 cell model].
abstract: OBJECTIVE
  To establish and evaluate the Caco-2 cell model.
  
  
  METHODS
  Caco-2 cell model was evaluated by morphology feature, TEER alkaline phosphatase and the transport of Propranolol.
  
  
  RESULTS
  The determined values were corresponding to the references. The integrality, permeability and the expression of alkaline phosphatase in the cell model were superior.
  
  
  CONCLUSIONS
  The established Caco-2 cell model can be used to study the absorption mechanism of oral administration drug.
authors.affiliation: School of Life Science, Sun Yat-sen University, Guangzhou 510275, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Ma
authors.forename: Pei-bo
authors.initials: PB
authors.lastname: Li
authors.forename: Wei-wei
authors.initials: WW
authors.lastname: Su
authors.forename: Da-wei
authors.initials: DW
authors.lastname: Chen
mesh_terms: D000469:Alkaline Phosphatase / Q000378:metabolism; D001692:Biological Transport / Q000502:physiology; D018938:Caco-2 Cells; D018929:Cell Culture Techniques / Q000379:methods*; D002463:Cell Membrane Permeability; D049109:Cell Proliferation; D003470:Culture Media / Q000494:pharmacology; D017097:Electric Impedance; D005069:Evaluation Studies as Topic; D006801:Humans; D007408:Intestinal Absorption; D008954:Models, Biological; D010539:Permeability; D011433:Propranolol / Q000378:metabolism
chemical_list: D003470:Culture Media; D011433:Propranolol; D000469:Alkaline Phosphatase