[Effects of annao tablet on S100B and NPY of cortex in chronic epilepsy rats].
OBJECTIVE
To study the effects of Annao tablet (main component is beta-asarone) on S100B and NPY of cortex in chronic epilepsy rats.


METHODS
The remedy was administered orally. The effects were observed in convulsion model induced by PG, then S100B protein and NPY of cortex were determined.


RESULTS
Annao tablet could depress the epileptic degree, postpone spasm latent period and reduce the wet dog sample (WDS) times. The remedy could decline S100B and NPY of cortex in chronic epilepsy rats.


CONCLUSIONS
Annao tablet has obvious antiepileptic effects and can reduce the nerve cell damage induced by epilepsy.
Fang
Ruo-Ming
RM
Guangzhou University of Traditional Chinese Medicine, Guangzhou 510405, China.
Fang
Geng-Li
GL
Fang
Yong-Qi
YQ
D029023:Acorus / Q000737:chemistry; D000081248:Allylbenzene Derivatives; D000818:Animals; D000840:Anisoles / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D000927:Anticonvulsants / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology; D002540:Cerebral Cortex / Q000378:metabolism*; D004337:Drug Carriers; D004827:Epilepsy / Q000378:metabolism* / Q000503:physiopathology; D005260:Female; D008297:Male; D009478:Neuropeptide Y / Q000378:metabolism*; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D009418:S100 Proteins / Q000378:metabolism*; D013607:Tablets; D047392:beta-Cyclodextrins
D000081248:Allylbenzene Derivatives; D000840:Anisoles; D000927:Anticonvulsants; D004337:Drug Carriers; D009478:Neuropeptide Y; D009418:S100 Proteins; D013607:Tablets; C012195:asarone; D047392:beta-Cyclodextrins