Type II collagen without adjuvant induces eosinophilic arthritis.
Eosinophilia is a characteristic feature of many inflammatory diseases including inflammatory bowel disease and asthma. It also occurs in a subtype of rheumatoid arthritis but the role of eosinophils has been unclear and animal models have been lacking. Here, we introduce a new mouse model to study the role of eosinophilia in arthritis. Intraperitoneal injection of type II collagen alone, without any adjuvant, was sufficient to induce chronic arthritis in a mouse with transgenic T cells specific for type II collagen. The arthritis was accompanied by infiltration of eosinophils into the synovial tissue and the disease could be blocked with neutralizing anti-IL-5 antibodies. To our knowledge, this is the first description of an eosinophilic disease form of destructive arthritis.
Bockermann
Robert
R
Medical Inflammation Research, BMC I11, University of Lund, Lund, Sweden.
Holmdahl
Rikard
R
D000276:Adjuvants, Immunologic; D000534:Alum Compounds; D000818:Animals; D001169:Arthritis, Experimental / Q000276:immunology* / Q000473:pathology; D024043:Collagen Type II / Q000235:genetics / Q000276:immunology*; D004195:Disease Models, Animal; D004802:Eosinophilia / Q000276:immunology* / Q000473:pathology; D051379:Mice; D008811:Mice, Inbred DBA; D008822:Mice, Transgenic; D010446:Peptide Fragments / Q000235:genetics; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000235:genetics
D000276:Adjuvants, Immunologic; D000534:Alum Compounds; D024043:Collagen Type II; D010446:Peptide Fragments; D016693:Receptors, Antigen, T-Cell, alpha-beta