The circling mouse (C57BL/6J-cir) has a 40-kilobase genomic deletion that includes the transmembrane inner ear (tmie) gene.
The circling mouse (C57BL6-cir) shows deafness and circling behavior in homozygotes. The mutation is transmitted with 100% penetrance by an autosomal recessive gene on chromosome 9. In the present study, we characterized the circling mutation as a 40-kilobase deletion that includes the transmembrane inner ear (tmie) gene. The tmie gene was first identified because its mutation causes deafness and circling behavior in spinner mice. We suggest that the genomic deletion of circling mice is a different, but allelic, mutation to that of spinner mice. In addition, during general behavioral investigations for complementation tests of the 2 strains, we found that circling and spinner mice may differ in their behavioral responses to a new environment.
Cho
Kyoung In
KI
Department of Medical Genetics and Experimental Animal Center, College of Medicine, Hallym University, Chunchon 200-702, South Korea. jaewoong64@hanmail.net
Suh
Jun-Gyo
JG
Lee
Jeong Woong
JW
Hong
Sung Hwa
SH
Kang
Tae-Cheon
TC
Oh
Yang-Seok
YS
Ryoo
Zae Young
ZY
D000483:Alleles; D000818:Animals; D001483:Base Sequence; D001522:Behavior, Animal; D001947:Breeding; D017931:DNA Primers / Q000235:genetics; D003638:Deafness / Q000235:genetics*; D004195:Disease Models, Animal; D005260:Female; D017353:Gene Deletion; D005808:Genes, Recessive; D005816:Genetic Complementation Test; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D051379:Mice; D008810:Mice, Inbred C57BL; D008817:Mice, Mutant Strains; D009154:Mutation
D017931:DNA Primers; D008565:Membrane Proteins