Chromatin modification and remodeling in heart development.
In organogenesis, cell types are specified from determined precursors as morphogenetic patterning takes place. These events are largely controlled by tissue-specific transcription factors. These transcription factors must function within the context of chromatin to activate or repress target genes. Recent evidence suggests that chromatin-remodeling and -modifying factors may have tissue-specific function. Here we review the potential roles for chromatin-remodeling and -modifying proteins in the development of the mammalian heart.
Delgado-Olguín
Paul
P
Programmes in Cardiovascular Research and Developmental Biology, The Hospital for Sick Children, Toronto, ON, Canada. pauldemian@gmail.com
Takeuchi
Jun K
JK
Bruneau
Benoit G
BG
D000818:Animals; D002843:Chromatin / Q000378:metabolism*; D042002:Chromatin Assembly and Disassembly / Q000502:physiology*; D006321:Heart / Q000196:embryology* / Q000254:growth & development; D006657:Histones / Q000378:metabolism / Q000502:physiology; D006801:Humans; D008954:Models, Biological; D038081:Organogenesis / Q000502:physiology
D002843:Chromatin; D006657:Histones