Detection of two porcine circovirus type 2 genotypic groups in United States swine herds.
In late 2005, sporadic cases of an acute onset disease of high mortality were observed in 10- to 16-week-old growing pigs among several swine herds of the United States. Tissues from the affected pigs in Kansas, Iowa, and North Carolina were examined, and porcine circovirus type 2 (PCV2) was detected consistently among these tissues. Phylogenetically, PCV2 can be divided into two major genotypic groups, PCV2-group 1 and PCV2-group 2. Whereas PCV2-group 1 isolates were detected in all the diseased animals, only two of the diseased animals harbored PCV2-group 2 isolates. This observation is important because PCV2-group 1 isolates had never been reported in the United States before (GenBank as of May 16, 2006), and they are closely related to the PCV2-group 1 isolates that have been described in Europe and Asia, previously. Our analysis revealed that each genotypic group contains a distinct stretch of nucleotide or amino acid sequence that may serve as a signature motif for PCV2-group 1 or PCV2-group 2 isolates.
Cheung
A K
AK
Virus and Prion Diseases of Livestock Research Unit, National Animal Disease Center, USDA-Agricultural Research Service, Ames, Iowa 50010, USA. acheung@nadc.ars.usda.gov
Lager
K M
KM
Kohutyuk
O I
OI
Vincent
A L
AL
Henry
S C
SC
Baker
R B
RB
Rowland
R R
RR
Dunham
A G
AG
D000822:Animal Husbandry; D000818:Animals; D018173:Circoviridae Infections / Q000662:veterinary* / Q000821:virology; D017925:Circovirus / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification; D016679:Genome, Viral; D010802:Phylogeny; D013045:Species Specificity; D013552:Swine; D013553:Swine Diseases / Q000821:virology*; D014481:United States