Synthesis of amino derivatives of 10-(diphenylmethylene)-4-azatricyclo[5.2.1.0(2,6)]dec-8-ene-3,5-dione as potential psychotropic and/or anti HIV agents.
A series of amino derivatives of 10-(diphenylmethylene)-4-azatricyclo[5.2.1.0(2.6)]dec-8-ene-3,5-dione, analogues of chlorpromazine and aminoperazine have been prepared. These compounds are expected to have antipsychotic and/or anti HIV activity. Molecular structure of III was confirmed by an X-ray structure analysis. The cytotoxicity and anti HIV activity of derivatives I-IV were determined.
Kossakowski
Jerzy
J
Department of Medical Chemistry, The Medical University of Warsaw, 3 Oczki Street, 02-007 Warsaw, Poland. jerzykos@amwaw.edu.pl
Wojciechowska
Anna
A
Kozioł
Anna E
AE
D019380:Anti-HIV Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002460:Cell Line; D018360:Crystallography, X-Ray; D015497:HIV-1 / Q000187:drug effects; D006572:Heterocyclic Compounds, Bridged-Ring / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D011619:Psychotropic Drugs / Q000138:chemical synthesis* / Q000494:pharmacology*
D019380:Anti-HIV Agents; D006572:Heterocyclic Compounds, Bridged-Ring; D007202:Indicators and Reagents; D011619:Psychotropic Drugs