title: B-type natriuretic peptide is not a marker of ischemia during dobutamine stress echocardiography.
abstract: Elevated levels of B-type natriuretic peptide (BNP) have been reported in association with exercise-induced ischemia. Data regarding BNP as a marker of ischemia during dobutamine stress echocardiography (DSE) are not conclusive. This study was designed to evaluate changes in BNP during DSE. A total of 74 patients referred to rule out ischemia by DSE were enrolled in the study. All patients had DSE using standard protocol. Of 74 patients enrolled, 6 were excluded because of nondiagnostic tests. Of the remaining 68 patients, 15 had positive DSE and 53 were negative for ischemia. The BNP levels (mean +/- SD) in the patients without ischemia were 42.5 pg/mL (+/-SD 47.6) at baseline and 41.9 pg/mL (+/-SD 48.9) at peak, and the measurements in the patients with ischemia were 90 pg/mL (+/-SD 171.7) at baseline and 88 pg/mL (+/-SD 149.2) at peak. BNP levels do not change during DSE with or without evidence of ischemia.
authors.affiliation: Division of Cardiology, University of Texas Medical Branch, Galveston, Texas 77555, USA.
authors.forename: Guillermo
authors.initials: G
authors.lastname: Salinas
authors.forename: Iyad N
authors.initials: IN
authors.lastname: Daher
authors.forename: Anthony O
authors.initials: AO
authors.lastname: Okorodudu
authors.forename: Masood
authors.initials: M
authors.lastname: Ahmad
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D003327:Coronary Disease / Q000000981:diagnostic imaging* / Q000503:physiopathology; D025401:Echocardiography, Stress / Q000009:adverse effects / Q000379:methods*; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D017202:Myocardial Ischemia / Q000097:blood* / Q000209:etiology; D020097:Natriuretic Peptide, Brain / Q000032:analysis / Q000097:blood*; D011446:Prospective Studies; D012016:Reference Values; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D018709:Statistics, Nonparametric
chemical_list: D015415:Biomarkers; D020097:Natriuretic Peptide, Brain