[Does FSH signaling have a gender?].
FSH is the main endocrine control of mammalian reproduction. FSH triggers somatic cells of the gonads which support germ cells metabolically, i.e. Sertoli cells of the seminiferous tubules, and granulosa cells harboring the oocyte, within the ovarian follicle. FSH leads to similar biological responses in both cell types since it stimulates proliferation and differentiation, according to the developmental stage. However, FSH receptor knock-out female mice are infertile, unlike male mice. Hence, FSH is not equally important in both sexes. Nevertheless, does FSH induce distinct signalling mechanisms in its target cells ? Here, we compare the signalling mechanisms induced by FSH in ovarian and testicular physiology.
Lécureuil
Charlotte
C
Physiologie de la Reproduction et des Comportements, UMR 6175 INRA-CNRS-Université de Tours-Haras Nationaux-IFR 135, 37380 Nouzilly, France.
Kara
Elodie
E
Guillou
Florian
F
Monniaux
Danielle
D
Crépieux
Pascale
P
D019943:Amino Acid Substitution; D000818:Animals; D002455:Cell Division / Q000502:physiology; D005640:Follicle Stimulating Hormone / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D006801:Humans; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D009154:Mutation; D012098:Reproduction / Q000502:physiology*; D012727:Sex Characteristics; D015398:Signal Transduction
D005640:Follicle Stimulating Hormone