title: Bilateral reduction mammaplasty for immediate breast conservation surgery reconstruction and intraoperative radiotherapy: a preliminary report.
abstract: BACKGROUND
  Breast conservation surgery and postoperative radiotherapy are widely accepted as the treatment of choice for patients with early breast cancer. Despite its oncologic benefits, the radiotherapy may cause unpredictable outcomes in soft tissues, especially in patients undergoing breast reconstruction. Described recently, intraoperative irradiation (IORT) has been indicated for selected patients as an alternative to radiotherapy with fewer adverse local effects. Clinical use of reduction mammaplasty (RM) techniques in oncologic breast surgery has been described previously. However, no previous studies have mentioned its application after breast conservation surgery and IORT.
  
  
  METHODS
  The authors used RM to reconstruct a partial breast tissue defect secondary to breast conservation surgery followed by IORT treatment in a 46-year-old patient with an 11-mm invasive ductal carcinoma between the superior internal quadrants of the right breast.
  
  
  RESULTS
  Satisfactory breast volume and shape were achieved, and no immediate or late complications were observed. After 2 postoperative years, no evidence of fat necrosis, tumor recurrence, or tissue volume loss was observed.
  
  
  CONCLUSIONS
  The initial data indicate that RM in the setting of breast conservation surgery reconstruction and IORT is feasible. With appropriate patient selection, respecting indications and limitations, RM has its place among the various reconstructive techniques. Additional studies with larger clinical series and longer follow-up periods are necessary to analyze the precise IORT effects in patients submitted to immediate breast conservation surgery reconstruction.
authors.affiliation: Department of Plastic Surgery, University of São Paulo and Hospital Sírio-Libanês, São Paulo, Rua da Consolação 3605 ap 91, 01416-001, Sao Paulo, SP, Brazil. munhozalex@uol.com.br
authors.forename: Alexandre Mendonça
authors.initials: AM
authors.lastname: Munhoz
authors.forename: José Roberto
authors.initials: JR
authors.lastname: Filassi
authors.forename: Claudia
authors.initials: C
authors.lastname: Aldrighi
authors.forename: Marcos Desidério
authors.initials: MD
authors.lastname: Ricci
authors.forename: Eduardo
authors.initials: E
authors.lastname: Martella
authors.forename: Alfredo Carlos
authors.initials: AC
authors.lastname: de Barros
authors.forename: Rolf
authors.initials: R
authors.lastname: Gemperli
authors.forename: Marcus Castro
authors.initials: MC
authors.lastname: Ferreira
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000532:radiotherapy* / Q000601:surgery*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007432:Intraoperative Period; D016462:Mammaplasty; D015412:Mastectomy, Segmental