title: Antihypertensive and natriuretic effects of less-sodium soy sauce containing gamma-aminobutyric acid in spontaneously hypertensive rats.
abstract: We investigated the mechanism of the antihypertensive effect of less-sodium soy sauce containing gamma-aminobutyric acid (GABA) in spontaneously hypertensive rats (SHRs). When SHRs were given a diet with less-sodium soy sauce containing GABA (GABA-rich soy sauce group) for 6 weeks, the systolic blood pressure decreased as compared with that in rats fed diets with less-sodium soy sauce or a solution of salt. Renal sympathetic nerve activity (RSNA) and positive Na balance were reduced, and the urinary Na excretion tended to increase in the GABA-rich soy sauce group. Vascular hypertrophy of the thoracic aorta and the coronary and renal interlobular arteries tended to reduce in the GABA-rich soy sauce group. These results suggest that inhibition of Na retention by natriuresis, as a result of inhibition of RSNA by the GABA in the soy sauce contributed to the antihypertensive effect of GABA in the SHRs. Intake of less-sodium soy sauce containing GABA might help to reduce overall cardiovascular risk.
authors.affiliation: Research and Development Division, Kikkoman Corporation, Japan. jyamakoshi@mail.kikkoman.co.jp
authors.forename: Jun
authors.initials: J
authors.lastname: Yamakoshi
authors.forename: Satoshi
authors.initials: S
authors.lastname: Fukuda
authors.forename: Takuya
authors.initials: T
authors.lastname: Satoh
authors.forename: Ryouhei
authors.initials: R
authors.lastname: Tsuji
authors.forename: Makoto
authors.initials: M
authors.lastname: Saito
authors.forename: Akio
authors.initials: A
authors.lastname: Obata
authors.forename: Asahi
authors.initials: A
authors.lastname: Matsuyama
authors.forename: Mamoru
authors.initials: M
authors.lastname: Kikuchi
authors.forename: Terukazu
authors.initials: T
authors.lastname: Kawasaki
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001794:Blood Pressure / Q000187:drug effects; D006973:Hypertension / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology; D006984:Hypertrophy / Q000188:drug therapy / Q000473:pathology; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D008297:Male; D045283:Natriuretic Agents / Q000494:pharmacology*; D051381:Rats; D011918:Rats, Inbred SHR; D012964:Sodium; D045730:Soy Foods; D005680:gamma-Aminobutyric Acid / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D000959:Antihypertensive Agents; D045283:Natriuretic Agents; D005680:gamma-Aminobutyric Acid; D012964:Sodium