title: Comorbidity in patients with cancer: prevalence and severity measured by cumulative illness rating scale.
abstract: Comorbidity is defined as the presence of one or more diseases in addition to an index disease. In elderly people, the number and severity of comorbidity increase with age. We report the comorbidity data of 536 patients treated as in-patients: 231 elderly cancer patients (ECP), 172 younger cancer patients (YCP) and 133 elderly patients admitted for non-cancer reasons (EMP). Comorbidity was assessed with the cumulative illness rating scale geriatric version (CIRS-G). Data on number of affected organ systems (levels 1-4), number of affected organ systems with severe disease (levels 3-4), and sum score of levels per patient are reported. The number of comorbidities increases with age. A 76% of ECP, 51% of YCP, and 79% of EMP have severe comorbidity. Palliative treatment approach is not associated with higher levels of comorbidity in ECP. Vascular disorders were the most common comorbidity. The difficulty to rate haematological comorbidity in cancer patients is reflected. This is the first report on detailed results of assessment of comorbidity measured by CIRS-G in cancer patients. In addition, we provide a comparison to an elderly group of patients admitted for non-cancer reasons.
authors.affiliation: Department for Internal Medicine II, Division of Haematology and Medical Oncology, Friedrich Schiller University, Erlanger Allee 101, 07747 Jena, Germany. ulrich.wedding@med.uni-jena.de
authors.forename: Ulrich
authors.initials: U
authors.lastname: Wedding
authors.forename: Bernd
authors.initials: B
authors.lastname: Roehrig
authors.forename: Almuth
authors.initials: A
authors.lastname: Klippstein
authors.forename: Peggy
authors.initials: P
authors.lastname: Steiner
authors.forename: Thomas
authors.initials: T
authors.lastname: Schaeffer
authors.forename: Ludger
authors.initials: L
authors.lastname: Pientka
authors.forename: Klaus
authors.initials: K
authors.lastname: Höffken
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D015897:Comorbidity; D005260:Female; D015577:Geriatric Assessment; D005853:Geriatrics; D006801:Humans; D017567:Karnofsky Performance Status; D008297:Male; D008495:Medical Oncology; D008875:Middle Aged; D009369:Neoplasms / Q000453:epidemiology*; D010166:Palliative Care; D012720:Severity of Illness Index; D018434:Sickness Impact Profile; D014652:Vascular Diseases / Q000453:epidemiology*