A new hepatitis B virus vaccine escape mutation in a renal transplant recipient.
Surface antigen mutations of hepatitis B virus (HBV) may lead to immune escape and cause failure of immunization. In this report, the development of a chronic HBV infection in a vaccinated renal transplant recipient with pre-existing anti-HBs antibody is documented. The sequencing data showed that the HBV strain carried five amino acid substitutions in the major hydrophilic region of the S protein, one (sS143L) located at the "a" determinant. A commercial HBsAg assay failed to detect the mutant antigen.
Sayiner
A Arzu
AA
Department of Clinical Microbiology, Dokuz Eylul University School of Medicine, 35340 Inciralti, Izmir, Turkey. arzu.sayiner@deu.edu.tr
Agca
Harun
H
Sengonul
Aylin
A
Celik
Ali
A
Akarsu
Mesut
M
D000328:Adult; D001483:Base Sequence; D005260:Female; D006514:Hepatitis B Surface Antigens / Q000235:genetics* / Q000276:immunology; D017325:Hepatitis B Vaccines / Q000276:immunology* / Q000627:therapeutic use; D006515:Hepatitis B virus / Q000235:genetics* / Q000276:immunology; D019698:Hepatitis C, Chronic / Q000276:immunology* / Q000517:prevention & control; D006801:Humans; D016030:Kidney Transplantation / Q000276:immunology*; D008969:Molecular Sequence Data; D009154:Mutation
D006514:Hepatitis B Surface Antigens; D017325:Hepatitis B Vaccines