The role of extracellular matrix in CNS regeneration.
Chondroitin sulfate proteoglycans are the principal inhibitory component of glial scars, which form after damage to the adult central nervous system and act as a barrier to regenerating axons. Recent findings have furthered our understanding of the mechanisms that result in a failure of regeneration after spinal cord injury and suggest that a multipartite approach will be required to facilitate long-distance regeneration and functional recovery.
Busch
Sarah A
SA
Case Western Reserve University School of Medicine, Department of Neurosciences, 2109 Adelbert Road E-658, Cleveland, Ohio 44106, USA.
Silver
Jerry
J
D000818:Animals; D002490:Central Nervous System / Q000293:injuries / Q000378:metabolism* / Q000503:physiopathology; D011508:Chondroitin Sulfate Proteoglycans / Q000378:metabolism*; D002921:Cicatrix / Q000378:metabolism / Q000503:physiopathology / Q000517:prevention & control; D005109:Extracellular Matrix / Q000378:metabolism*; D005911:Gliosis / Q000378:metabolism / Q000503:physiopathology / Q000517:prevention & control; D020439:Growth Cones / Q000378:metabolism / Q000648:ultrastructure; D006131:Growth Inhibitors / Q000378:metabolism; D006801:Humans; D009416:Nerve Regeneration / Q000502:physiology*; D013119:Spinal Cord Injuries / Q000378:metabolism* / Q000503:physiopathology / Q000628:therapy
D011508:Chondroitin Sulfate Proteoglycans; D006131:Growth Inhibitors