title: Preanalytical conditions that affect coagulation testing, including hormonal status and therapy.
abstract: Preanalytical conditions, be they due to the individual's physiologic state or to exogenous factors, can affect coagulation factors, in either a transient or a persistent manner, and need to be considered in laboratory testing. These conditions include physical and mental stress, diurnal variation, hormone levels and posture at the time of blood drawing. While testing of these factors has not been exhaustive and some results are conflicting, guidelines for testing conditions can be given.
authors.affiliation: Department of Molecular Medicine and Surgery, Coagulation Research, Karolinska University Hospital, Stockholm, Sweden.
authors.forename: M
authors.initials: M
authors.lastname: Blombäck
authors.forename: B A
authors.initials: BA
authors.lastname: Konkle
authors.forename: M J
authors.initials: MJ
authors.lastname: Manco-Johnson
authors.forename: K
authors.initials: K
authors.lastname: Bremme
authors.forename: M
authors.initials: M
authors.lastname: Hellgren
authors.forename: R
authors.initials: R
authors.lastname: Kaaja
mesh_terms: D000925:Anticoagulants / Q000008:administration & dosage / Q000627:therapeutic use; D001777:Blood Coagulation; D001800:Blood Specimen Collection / Q000379:methods*; D003276:Contraceptives, Oral / Q000627:therapeutic use; D015444:Exercise; D005260:Female; D006728:Hormones / Q000097:blood*; D006801:Humans; D007202:Indicators and Reagents; D019934:International Normalized Ratio; D008297:Male; D008597:Menstrual Cycle; D011247:Pregnancy; D011517:Prothrombin Time / Q000295:instrumentation; D013315:Stress, Psychological
chemical_list: D000925:Anticoagulants; D003276:Contraceptives, Oral; D006728:Hormones; D007202:Indicators and Reagents