[Effect of Huangbai Liquid on expression of human beta-defensin-2 mRNA in skin lesions of patients with recurrent genital herpes].
OBJECTIVE
To investigate the expression of human beta-defensin-2 (HBD-2) mRNA in skin lesions of patients with recurrent genital herpes (RGH) and the effect of Huangbai Liquid (HL) on it.


METHODS
Twenty-seven patients were randomly assigned to 2 groups, the HL group (n = 14) treated with HL and the famciclovir group (n = 13) with famciclovir. HBD-2 expression of patients were detected before and after the treatment and compared with that of 10 healthy subjects.


RESULTS
HBD-2 expression was found in the skin lesions of both the healthy persons and the RGH patients before treatment. It is higher significantly in the HL group than in the famciclovir group after treatment.


CONCLUSIONS
HL was suitable for treatment of RGH since it could improve immune function of RGH patients and keep a rather higher concentration of HBD-2 expression in local skin lesions.
Ren
Xiao-Li
XL
Department of Dermatology, Taizhou Municipal Hospital, Zhejiang. xlxy1998@shou.com
Chen
Jin-Guang
JG
D000328:Adult; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D015870:Gene Expression / Q000187:drug effects; D006558:Herpes Genitalis / Q000188:drug therapy* / Q000235:genetics / Q000821:virology; D018258:Herpesvirus 2, Human / Q000187:drug effects; D006801:Humans; D008297:Male; D008517:Phytotherapy; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction; D055502:Secondary Prevention; D012867:Skin / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D023083:beta-Defensins / Q000235:genetics*
D004365:Drugs, Chinese Herbal; D012333:RNA, Messenger; D023083:beta-Defensins; C528424:huangbai