Serum and ovarian Müllerian inhibiting substance, and their decline in reproductive aging.
The objectives of this study were to identify whether there is a decline in Müllerian inhibiting substance (MIS) in the female rat during chronological aging, and to define the physiological basis of aging-related changes in MIS. The results demonstrate that there is an exponential decline in both serum and ovarian levels of MIS with increasing female age, and that the histologic origin for the reduction in serum levels of MIS is a decline in the number of small ovarian follicles expressing MIS.
Yeh
John
J
Department of Gynecology-Obstetrics, University at Buffalo, The State University of New York, Buffalo, New York 14222, USA. jyeh@buffalo.edu
Kim
Beomsu
B
Peresie
Jennifer
J
Liang
Yuan Jing
YJ
Arroyo
Armando
A
D000375:Aging / Q000097:blood* / Q000378:metabolism; D000818:Animals; D054304:Anti-Mullerian Hormone; D005260:Female; D006023:Glycoproteins / Q000096:biosynthesis / Q000097:blood* / Q000172:deficiency; D010053:Ovary / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012098:Reproduction / Q000502:physiology*; D013735:Testicular Hormones / Q000096:biosynthesis / Q000097:blood* / Q000172:deficiency
D006023:Glycoproteins; D013735:Testicular Hormones; D054304:Anti-Mullerian Hormone