title: Does botulinum toxin decrease frequency and severity of sialorrhea in Parkinson's disease?
abstract: This study analysed if botulinum toxin type A (BTX-A) decreases drooling in 21 Parkinson's disease patients. BTX-A injections were given in the parotid glands. The severity of drooling decreased in 18 (86%) patients, while frequency was reduced in 8 (38%). In 11(52%) patients, the frequency of drooling remained constant, which may reflect more difficulties in swallowing, compared to the group that presented such improvement. Future trials assessing the level of swallowing dysfunction may be important to establish a prognosis for patients who keep the frequency of drooling in spite of decreased severity after BTX injection.
authors.affiliation: Division of Neurology and Epidemiology, Federal University of Bahia, Brazil.
authors.forename: Ana Caline
authors.initials: AC
authors.lastname: Nóbrega
authors.forename: Bernardo
authors.initials: B
authors.lastname: Rodrigues
authors.forename: Ana Catarina
authors.initials: AC
authors.lastname: Torres
authors.forename: Alfredo
authors.initials: A
authors.lastname: Enzo
authors.forename: Ailton
authors.initials: A
authors.lastname: Melo
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D019274:Botulinum Toxins, Type A / Q000008:administration & dosage* / Q000009:adverse effects; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009465:Neuromuscular Agents / Q000008:administration & dosage* / Q000009:adverse effects; D010300:Parkinson Disease / Q000150:complications*; D012798:Sialorrhea / Q000188:drug therapy* / Q000209:etiology*; D016896:Treatment Outcome
chemical_list: D009465:Neuromuscular Agents; D019274:Botulinum Toxins, Type A