Evaluation of a novel enzyme-linked immunosorbent assay to detect immunoglobulin G antibody to enolase for serodiagnosis of invasive candidiasis.
The performance of a new test to detect antibodies to Candida albicans recombinant enolase was investigated in 47 immunocompromised and 51 immunocompetent patients. The sensitivity, specificity, and positive and negative predictive values of the test for the diagnosis of invasive candidiasis were 81.0, 83.9, 79.1, and 85.5%, respectively.
Laín
Ana
A
Departamento de Inmunología, Microbiología y Parasitología, Facultad de Medicina y Odontología, Universidad del País Vasco, Apartado 699, E-48080 Bilbao, Vizcaya, Spain.
Moragues
María D
MD
Ruiz
Juan Carlos García
JC
Mendoza
Joaquín
J
Camacho
Ana
A
Del Palacio
Amalia
A
Pontón
José
J
D000328:Adult; D000908:Antibodies, Fungal / Q000097:blood*; D002176:Candida albicans / Q000276:immunology*; D002177:Candidiasis / Q000175:diagnosis*; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D010751:Phosphopyruvate Hydratase / Q000276:immunology*; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D012698:Serologic Tests
D000908:Antibodies, Fungal; D007074:Immunoglobulin G; D010751:Phosphopyruvate Hydratase