title: Chemical composition and antimicrobial activity of the essential oil of Cryptomeria japonica.
abstract: The composition and the antibacterial activity of the essential oil obtained from Cryptomeria japonica D. Don on oral bacteria were studied. The chemical composition of the essential oil was analysed by GC and GC-MS. Sixty-eight compounds accounting for 95.82% of the oil were identified. The main compounds in the oil were alpha-pinene (6.07%), sabinene (8.86%), terpinen-4-ol (9.77%), alpha-terpineol (6.13%), elemol (11.17%) and 10(15)-cadinen-4-ol (7.16%). The essential oil and some of its major compounds were tested for antimicrobial activity against 15 different genera of oral bacteria. The essential oil of C. japonica exhibited considerable inhibitory effects against all bacteria tested (MICs, 0.025-0.05 mg/mL; MBCs, 0.025-0.1 mg/mL), while its major compounds demonstrated various degrees of growth inhibition.
authors.affiliation: Institute of Oral Bioscience and Department of Oral Microbiology, School of Dentistry, Chonbuk National University, Jeonju, South Korea.
authors.forename: Jeong-Dan
authors.initials: JD
authors.lastname: Cha
authors.forename: Mi-Ran
authors.initials: MR
authors.lastname: Jeong
authors.forename: Seung-Il
authors.initials: SI
authors.lastname: Jeong
authors.forename: Sang-Eun
authors.initials: SE
authors.lastname: Moon
authors.forename: Bong-Seop
authors.initials: BS
authors.lastname: Kil
authors.forename: Soon-Il
authors.initials: SI
authors.lastname: Yun
authors.forename: Kyung-Yeol
authors.initials: KY
authors.lastname: Lee
authors.forename: Yo-Han
authors.initials: YH
authors.lastname: Song
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D032485:Cryptomeria; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D006801:Humans; D008826:Microbial Sensitivity Tests; D009055:Mouth / Q000382:microbiology; D008517:Phytotherapy; D018515:Plant Leaves; D010938:Plant Oils / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D010938:Plant Oils