[C-reactive protein in cardiovascular diseases].
The half of all hart attacks and strokes occurred among persons without elevated LDL- cholesterol concentration. This statment indicates a necessity for consideration of additional factors allowed for identification of patients with high risk of cardiovascular diseases, other than high cholesterol level. The precise determination of inflammation in the atherogenesis process paid attention to biological inflammatory markers as indicators of development and course of atheromatosis related diseases. C-reactive protein ranked as an acute phase protein, produced by the liver as an answer to cytokine stimulation is an acknowledged inflammatory marker. The measurement of CRP concentration is traditionally used to establish diagnosis and course as a monitor of inflammatory and neoplastic diseases. The last few years brought a lot of data that suggested usefulness of CRP concentration measurements in cardiovascular diseases. Putting into diagnostics the measurement of CRP as a high sensitivity CRP method allowed to precisely determining the connection between atherogenesis process development and its complications. The aim of this paper is presentation of current knowledge concerning connection between CRP and cardiovascular diseases.
Lubas
Wojciech
W
Oddział Chorób Wewnetrznych, z Pododdziałem Intensywnej, Opieki Kardiologicznej Szpitala Ministerstwa, Spraw Wewnqtrznych i Administracji, w Rzeszowie. intmsw@mp.pl
Gutkowski
Krzysztof
K
D000465:Algorithms; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis* / Q000187:drug effects*; D002318:Cardiovascular Diseases / Q000175:diagnosis / Q000517:prevention & control; D003324:Coronary Artery Disease / Q000175:diagnosis* / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000097:blood; D018836:Inflammation Mediators / Q000032:analysis; D017035:Pravastatin / Q000627:therapeutic use; D011237:Predictive Value of Tests; D012307:Risk Factors; D012680:Sensitivity and Specificity
D015415:Biomarkers; D018836:Inflammation Mediators; D002097:C-Reactive Protein; D017035:Pravastatin