[The cell micro-encapsulation techniques and its advancement in the field of gene therapy].
It is no doubt that the gene therapy using recombinant engineering cells provides a novel approach to many refractory diseases. However, the transplant rejection from the host's immune system against heterogeneous cells has been the main handicap of its clinical application. The modern cell micro-encapsulation technique with good immune isolation makes it possible to overcome this problem and has shown potential application foreground in clinical therapies for a lot of diseases such as Parkinson's disease and Hemophiliac disease. This article reviews mainly the relative materials and techniques in processing micro-encapsulation, the host cells used to construct the recombinant genetic engineering cells and application of cell micro-encapsulation technique in the field of gene therapy.
Li
Xiaoling
X
Department of Clinical Pharmacology, Pharmacy College of Jinan University, Guangzhou 510632, China.
Cai
Shaohui
S
D001698:Biomedical Engineering / Q000379:methods / Q000639:trends*; D017690:Cell Transplantation / Q000379:methods / Q000639:trends*; D015316:Genetic Therapy / Q000639:trends*; D006801:Humans; D008904:Miniaturization; D023822:Tissue Engineering / Q000379:methods / Q000639:trends*