title: No association between the +874T/A single nucleotide polymorphism in the IFN-gamma gene and susceptibility to TB.
abstract: A single nucleotide polymorphism (SNP), +874T/A, in the first intron of the interferon-gamma (IFN-gamma) gene, has presented associations with human susceptibility to tuberculosis (TB) in some ethnic populations, but not in others. In this population-based case-control study with adult TB patients from Houston, Texas, we found no significant differences of + 874T/A genotypic frequencies between cases and ethnically-matched controls or between advanced forms of TB disease (extra-pulmonary involvement or presence of cavitary disease) and pulmonary TB. Given possible sample size limitations, our results suggest that the IFN-gamma +874T/A mutation has no association with TB susceptibility or TB disease severity.
authors.affiliation: Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA.
authors.forename: A
authors.initials: A
authors.lastname: Moran
authors.forename: X
authors.initials: X
authors.lastname: Ma
authors.forename: R A
authors.initials: RA
authors.lastname: Reich
authors.forename: E A
authors.initials: EA
authors.lastname: Graviss
mesh_terms: D000328:Adult; D000483:Alleles; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007371:Interferon-gamma / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D013781:Texas; D014376:Tuberculosis / Q000235:genetics*
chemical_list: D007371:Interferon-gamma