Roles of the LHX3 and LHX4 LIM-homeodomain factors in pituitary development.
The LHX3 and LHX4 LIM-homeodomain transcription factors play essential roles in pituitary gland and nervous system development. Mutations in the genes encoding these regulatory proteins are associated with combined hormone deficiency diseases in humans and animal models. Patients with these diseases have complex syndromes involving short stature, and reproductive and metabolic disorders. Analyses of the features of these diseases and the biochemical properties of the LHX3 and LHX4 proteins will facilitate a better understanding of the molecular pathways that regulate the development of the specialized hormone-secreting cells of the mammalian anterior pituitary gland.
Mullen
Rachel D
RD
Department of Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, IN 46202-5120, United States.
Colvin
Stephanie C
SC
Hunter
Chad S
CS
Savage
Jesse J
JJ
Walvoord
Emily C
EC
Bhangoo
Amrit P S
AP
Ten
Svetlana
S
Weigel
Johannes
J
Pfäffle
Roland W
RW
Rhodes
Simon J
SJ
D000818:Animals; D018398:Homeodomain Proteins / Q000235:genetics / Q000502:physiology*; D006801:Humans; D060850:LIM-Homeodomain Proteins; D009154:Mutation; D010902:Pituitary Gland / Q000196:embryology* / Q000502:physiology; D010907:Pituitary Hormones / Q000235:genetics / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics / Q000502:physiology*
D018398:Homeodomain Proteins; C486362:LHX4 protein, human; D060850:LIM-Homeodomain Proteins; C094898:Lhx3 protein; C108538:Lhx4 protein, mouse; D010907:Pituitary Hormones; D014157:Transcription Factors