title: Relationships between leptin, insulin, IGF-1 and IGFBP-3 in children with energy malnutrition.
abstract: OBJECTIVE
  Leptin has a key role in energy homeostasis and there may be a link between leptin and insulin-like growth factor-1 (IGF-1) system. The aim of this study was to analyze the relationships between long-lasting insufficient caloric intake (marasmus), leptin and IGF-1 system.
  
  
  METHODS
  The study group consisted of 30 marasmic children and control group included 28 healthy children. After an overnight fasting; leptin, insulin, IGF-1 and IGFBP-3 levels were measured.
  
  
  RESULTS
  Marasmic children had significantly lower body weight, height, mid-arm circumference (MAC), skinfold thickness, mean serum leptin, insulin, IGF-1 and IGFBP-3 levels compared with healthy subjects (P<0.05). Serum IGF-1 and IGFBP-3 levels were significantly correlated with insulin, MAC and height Z score in patients (P<0.05). In controls, significant positive correlations were found between BMI, IGF-1 and leptin (P<0.05).
  
  
  CONCLUSIONS
  Energy malnutrition is characterized by the important decreases in the leptin, insulin, IGF-1 and IGFBP-3 levels. Understanding details of these changes may lead to new therapeutic approaches in disease states associated with malnutrition.
authors.affiliation: Department of Pediatrics, Dicle University, Medical School, Diyarbakir, Turkey.
authors.forename: Kenan
authors.initials: K
authors.lastname: Haspolat
authors.forename: Aydin
authors.initials: A
authors.lastname: Ece
authors.forename: Fuat
authors.initials: F
authors.lastname: Gürkan
authors.forename: Yildiz
authors.initials: Y
authors.lastname: Atamer
authors.forename: Murat
authors.initials: M
authors.lastname: Tutanç
authors.forename: Ilyas
authors.initials: I
authors.lastname: Yolbaş
mesh_terms: D001827:Body Height; D015992:Body Mass Index; D001835:Body Weight; D005260:Female; D006801:Humans; D007223:Infant; D007328:Insulin / Q000097:blood*; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000097:blood*; D007334:Insulin-Like Growth Factor I / Q000032:analysis*; D020738:Leptin / Q000097:blood*; D008297:Male; D011502:Protein-Energy Malnutrition / Q000175:diagnosis*
chemical_list: D007328:Insulin; D018972:Insulin-Like Growth Factor Binding Protein 3; D020738:Leptin; D007334:Insulin-Like Growth Factor I