[Weekly paclitaxel therapy effective for gastric cancer with obstructive jaundice due to peritoneal dissemination--a case report].
The patient was a 61-year-old man who suffered from advanced gastric cancer, and a distal gastrectomy was performed (T3N2P1CY1, Stage IV). He was treated with chemotherapy of TS-1 alone (100 mg/day, days 1-28 with two weeks rest). Six months later he complained of lumbago and appetite loss, then was admitted to the hospital with obstructive jaundice. Total bilirubin (T-Bil) was increased to 11.3 mg/dl. CT scan examination revealed peritoneal dissemination with much ascites and dilatation of intrahepatic bile ducts. Endoscopic drainage was tried, but was discontinued due to stenosis of gastroduodenal anastomosis. Ultimately, T-Bil was elevated to 25.2 mg/dl, and he could not sleep comfortably because of a severe itch and an irritating feeling. Weekly paclitaxel therapy was started (70 mg/m(2), day 1, 8, 15, once a week for 3 weeks followed by a week rest as one cycle). One month after the first infusion therapy, the obstructive jaundice was notably improved and the ascites disappeared completely, so he was discharged. For about one year, he was treated with this chemotherapy as an outpatient. The toxic events were anemia (grade 3) and alopecia (grade 1).
Kawamoto
Kazuyuki
K
Dept. of Surgery, Kurashiki Central Hospital.
Yamaguchi
Kazushige
K
Okabe
Michio
M
Tsuruta
Atsushi
A
Morimoto
Yoshinori
Y
Niwano
Mototaka
M
Sano
Kaoru
K
Paku
Tebun
T
Imai
Shiro
S
Yoshida
Yasuo
Y
Ito
Tadashi
T
Ogasahara
Keizo
K
D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage*; D001201:Ascites / Q000209:etiology; D003131:Combined Modality Therapy; D004334:Drug Administration Schedule; D005743:Gastrectomy; D006801:Humans; D041781:Jaundice, Obstructive / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D017239:Paclitaxel / Q000008:administration & dosage*; D010534:Peritoneal Neoplasms / Q000556:secondary*; D012074:Remission Induction; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery
D000972:Antineoplastic Agents, Phytogenic; D017239:Paclitaxel