title: A pilot clinical trial of the effects of coenzyme Q10 on chronic tinnitus aurium.
abstract: OBJECTIVE
  To determine the short-term effects of coenzyme Q10 (CoQ10) on the antioxidative status and tinnitus expression in patients with chronic tinnitus aurium.
  
  
  METHODS
  A 16-week prospective nonrandomized clinical trial (n = 20). Tinnitus and Short Form-36 Questionnaires (TQ/SF-36) were evaluated together with the plasma concentrations of CoQ10, malondialdehyde, and the total antioxidant status.
  
  
  RESULTS
  The mean plasma CoQ10 concentration rose under external CoQ10 supply and remained elevated after medication stopped without overall effects on the tinnitus score. However, in a subgroup of 7 patients with low initial plasma CoQ10 concentration and significant increase in the plasma CoQ10 level, a clear decrease in the TQ score was observed.
  
  
  CONCLUSIONS
  In patients with a low plasma CoQ10 concentration, CoQ10 supply may decrease the tinnitus expression.
  
  
  CONCLUSIONS
  This is the first study to examine the effect of CoQ10 in chronic tinnitus aurium.
authors.affiliation: Department of Otorhinolaryngology, Charité-University Medicine Berlin, Berlin, Germany.
authors.forename: Martin
authors.initials: M
authors.lastname: Khan
authors.forename: Johann
authors.initials: J
authors.lastname: Gross
authors.forename: Heidemarie
authors.initials: H
authors.lastname: Haupt
authors.forename: Annett
authors.initials: A
authors.lastname: Jainz
authors.forename: Petra
authors.initials: P
authors.lastname: Niklowitz
authors.forename: Hans
authors.initials: H
authors.lastname: Scherer
authors.forename: Frank-Peter
authors.initials: FP
authors.lastname: Schmidt
authors.forename: Burghard F
authors.initials: BF
authors.lastname: Klapp
authors.forename: Anett
authors.initials: A
authors.lastname: Reisshauer
authors.forename: Birgit
authors.initials: B
authors.lastname: Mazurek
mesh_terms: D000328:Adult; D000368:Aged; D000975:Antioxidants / Q000032:analysis / Q000627:therapeutic use*; D002908:Chronic Disease; D003067:Coenzymes; D045222:Electron Transport Chain Complex Proteins / Q000097:blood / Q000627:therapeutic use*; D005260:Female; D006305:Health Status Indicators; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000032:analysis; D008875:Middle Aged; D011446:Prospective Studies; D014012:Tinnitus / Q000188:drug therapy* / Q000523:psychology; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000097:blood / Q000627:therapeutic use
chemical_list: D000975:Antioxidants; D003067:Coenzymes; D045222:Electron Transport Chain Complex Proteins; D014451:Ubiquinone; D008315:Malondialdehyde; C024989:coenzyme Q10