TRP channels of the pancreatic beta cell.
Orchestrated ion fluctuations within pancreatic islets regulate hormone secretion and maybe essential to processes such as apoptosis. A diverse set of ion channels allows for islet cells to respond to a variety of signals and dynamically regulate hormone secretion and glucose homeostasis (reviewed by Houamed et al. 2004). This chapter focuses on transient receptor potential (TRP)-related channels found within the beta cells of the islet and reviews their roles in both insulin secretion and apoptosis.
Jacobson
D A
DA
Department of Medicine-Endocrinology Section, University of Chicago, 5841 S Maryland Ave, Chicago, IL, USA.
Philipson
L H
LH
D000818:Animals; D006801:Humans; D050417:Insulin-Secreting Cells / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D007473:Ion Channels / Q000187:drug effects / Q000378:metabolism / Q000502:physiology; D009490:Neurosecretory Systems / Q000187:drug effects / Q000502:physiology; D050051:Transient Receptor Potential Channels / Q000037:antagonists & inhibitors / Q000378:metabolism / Q000502:physiology*
D007473:Ion Channels; D050051:Transient Receptor Potential Channels