title: Serum and ovarian Müllerian inhibiting substance, and their decline in reproductive aging.
abstract: The objectives of this study were to identify whether there is a decline in Müllerian inhibiting substance (MIS) in the female rat during chronological aging, and to define the physiological basis of aging-related changes in MIS. The results demonstrate that there is an exponential decline in both serum and ovarian levels of MIS with increasing female age, and that the histologic origin for the reduction in serum levels of MIS is a decline in the number of small ovarian follicles expressing MIS.
authors.affiliation: Department of Gynecology-Obstetrics, University at Buffalo, The State University of New York, Buffalo, New York 14222, USA. jyeh@buffalo.edu
authors.forename: John
authors.initials: J
authors.lastname: Yeh
authors.forename: Beomsu
authors.initials: B
authors.lastname: Kim
authors.forename: Jennifer
authors.initials: J
authors.lastname: Peresie
authors.forename: Yuan Jing
authors.initials: YJ
authors.lastname: Liang
authors.forename: Armando
authors.initials: A
authors.lastname: Arroyo
mesh_terms: D000375:Aging / Q000097:blood* / Q000378:metabolism; D000818:Animals; D054304:Anti-Mullerian Hormone; D005260:Female; D006023:Glycoproteins / Q000096:biosynthesis / Q000097:blood* / Q000172:deficiency; D010053:Ovary / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012098:Reproduction / Q000502:physiology*; D013735:Testicular Hormones / Q000096:biosynthesis / Q000097:blood* / Q000172:deficiency
chemical_list: D006023:Glycoproteins; D013735:Testicular Hormones; D054304:Anti-Mullerian Hormone