title: Noninvasive diffuse optical measurement of blood flow and blood oxygenation for monitoring radiation therapy in patients with head and neck tumors: a pilot study.
abstract: This pilot study explores the potential of noninvasive diffuse correlation spectroscopy (DCS) and diffuse reflectance spectroscopy (DRS) for monitoring early relative blood flow (rBF), tissue oxygen saturation (StO(2)), and total hemoglobin concentration (THC) responses to chemo-radiation therapy in patients with head and neck tumors. rBF, StO(2), and THC in superficial neck tumor nodes of eight patients are measured before and during the chemo-radiation therapy period. The weekly rBF, StO(2), and THC kinetics exhibit different patterns for different individuals, including significant early blood flow changes during the first two weeks. Averaged blood flow increases (52.7+/-9.7)% in the first week and decreases (42.4+/-7.0)% in the second week. Averaged StO(2) increases from (62.9+/-3.4)% baseline value to (70.4+/-3.2)% at the end of the second week, and averaged THC exhibits a continuous decrease from pretreatment value of (80.7+/-7.0) [microM] to (73.3+/-8.3) [microM] at the end of the second week and to (63.0+/-8.1) [microM] at the end of the fourth week of therapy. These preliminary results suggest daily diffuse-optics-based therapy monitoring is feasible during the first two weeks and may have clinical promise.
authors.affiliation: Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6396, USA. sunar@sas.upenn.edu
authors.forename: Ulas
authors.initials: U
authors.lastname: Sunar
authors.forename: Harry
authors.initials: H
authors.lastname: Quon
authors.forename: Turgut
authors.initials: T
authors.lastname: Durduran
authors.forename: Jun
authors.initials: J
authors.lastname: Zhang
authors.forename: Juan
authors.initials: J
authors.lastname: Du
authors.forename: Chao
authors.initials: C
authors.lastname: Zhou
authors.forename: Guoqiang
authors.initials: G
authors.lastname: Yu
authors.forename: Regine
authors.initials: R
authors.lastname: Choe
authors.forename: Alex
authors.initials: A
authors.lastname: Kilger
authors.forename: Robert
authors.initials: R
authors.lastname: Lustig
authors.forename: Laurie
authors.initials: L
authors.lastname: Loevner
authors.forename: Shoko
authors.initials: S
authors.lastname: Nioka
authors.forename: Britton
authors.initials: B
authors.lastname: Chance
authors.forename: Arjun G
authors.initials: AG
authors.lastname: Yodh
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood; D001783:Blood Flow Velocity; D005240:Feasibility Studies; D005260:Female; D006258:Head and Neck Neoplasms / Q000097:blood / Q000098:blood supply / Q000175:diagnosis* / Q000532:radiotherapy*; D006454:Hemoglobins / Q000032:analysis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood*; D010865:Pilot Projects; D011379:Prognosis; D011881:Radiotherapy, Computer-Assisted / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013057:Spectrum Analysis / Q000379:methods*; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor; D006454:Hemoglobins; D010100:Oxygen