An estrogen metabolism-related polymorphism of the 17-alpha HSD gene is associated with perimenopausal body mass index.
In a cross-sectional study of 2,802 perimenopausal caucasian women, carriage of at least one mutated allele of the 17-alpha-hydroxysteroid dehydrogenase type 1 (17-alpha HSD) vlV A-->C single nucleotide polymorphism (SNP) was associated with a significantly increased body mass index (mean 24.3 +/- 4.4 kg/m(2) vs. 23.5 +/- 4.2 kg/m(2); P<.001), and obesity was more frequent among mutant allele carriers (P=.06; odds ratio 1.38; 95% confidence interval 0.97-1.95), providing evidence of 17-alpha HSD as a candidate gene of perimenopausal obesity.
Tempfer
Clemens B
CB
Department of Gynecologic Endocrinology and Infertility Treatment, Medical University Vienna, Vienna, Austria. clemens.tempfer@meduniwien.ac.at <clemens.tempfer@meduniwien.ac.at>
Huber
Claudia
C
Huber
Johannes C
JC
Schneeberger
Christian
C
Bentz
Eva-Katrin
EK
Hefler
Lukas A
LA
D015992:Body Mass Index; D003430:Cross-Sectional Studies; D004247:DNA / Q000097:blood / Q000235:genetics / Q000302:isolation & purification; D005260:Female; D005838:Genotype; D006801:Humans; D006913:Hydroxysteroid Dehydrogenases / Q000235:genetics*; D008875:Middle Aged; D010298:Parity; D047648:Perimenopause / Q000235:genetics*; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D011247:Pregnancy
D004247:DNA; D006913:Hydroxysteroid Dehydrogenases; C035507:3(17)-hydroxysteroid dehydrogenase