title: The influence of cyclosporin a on mechanical retention of dental implants previously integrated to the bone: a study in rabbits.
abstract: BACKGROUND
  Immunosuppressive agents may induce severe changes on bone metabolism and may impair the osseointegration process during the implant healing. No data are available concerning the influence of cyclosporin A on dental implants previously integrated to the bone. The aim of this study was to evaluate the influence of cyclosporin A administration on the mechanical retention of bone previously integrated to dental implants.
  
  
  METHODS
  Eighteen female New Zealand rabbits were submitted to an implant surgery. Each animal received one commercial dental implant of 10 x 3.75 mm. After 12 weeks of an undisturbed healing period, six animals were randomly sacrificed and the removal torque test was performed (group A). In addition, six animals were submitted to a daily injection of cyclosporin A in a dosage of 10 mg/kg (group C), and six animals received saline solution as a control (group B). After 12 weeks of cyclosporin A administration, groups B and C were sacrificed and submitted to a removal torque test in which higher values can be interpreted as higher mechanical bone retention to the implant surface or higher osseointegration.
  
  
  RESULTS
  The removal torque results were 30.5 (+/-9.8) Ncm for group A, 50.17 (+/-17.5) Ncm for group B, and 26 (+/-7.8) Ncm for group C. The statistical analysis showed significant differences between groups A and B (P <0.05) and groups B and C (P <0.01).
  
  
  CONCLUSIONS
  Cyclosporin A administration may impair the mechanical retention of dental implants previously integrated to the bone.
authors.affiliation: Department of Periodontology, Educational Foundation of Barretos, Barretos, São Paulo, Brazil.
authors.forename: Celso E
authors.initials: CE
authors.lastname: Sakakura
authors.forename: Rogerio
authors.initials: R
authors.lastname: Margonar
authors.forename: Rafael
authors.initials: R
authors.lastname: Sartori
authors.forename: Juliana A N D
authors.initials: JA
authors.lastname: Morais
authors.forename: Elcio
authors.initials: E
authors.lastname: Marcantonio
mesh_terms: D000818:Animals; D016572:Cyclosporine / Q000627:therapeutic use*; D003758:Dental Implantation, Endosseous; D015921:Dental Implants; D017268:Dental Prosthesis Retention; D003799:Dental Stress Analysis; D005260:Female; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D016348:Osseointegration / Q000187:drug effects*; D011817:Rabbits; D011897:Random Allocation; D018709:Statistics, Nonparametric; D013977:Tibia / Q000601:surgery; D019415:Torque
chemical_list: D015921:Dental Implants; D007166:Immunosuppressive Agents; D016572:Cyclosporine