Effects of glutathione and ascorbic acid on streptomycin sensitivity of Escherichia coli.
We examined the effects of antioxidants and the role of reactive oxygen species (ROS) on the antibacterial action of aminoglycosides in Escherichia coli. We concluded that reduced streptomycin sensitivity in the presence of glutathione and ascorbic acid is not due to the antioxidant-mediated scavenging of ROS.
Goswami
Manish
M
Molecular Biology Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400085, India.
Mangoli
Suhas H
SH
Jawali
Narendra
N
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000494:pharmacology*; D002374:Catalase / Q000235:genetics; D004926:Escherichia coli / Q000187:drug effects*; D005978:Glutathione / Q000494:pharmacology*; D007202:Indicators and Reagents; D009580:Nitroblue Tetrazolium; D010544:Peroxidases / Q000235:genetics; D054464:Peroxiredoxins; D017382:Reactive Oxygen Species / Q000378:metabolism; D013307:Streptomycin / Q000494:pharmacology*; D013482:Superoxide Dismutase / Q000235:genetics
D000900:Anti-Bacterial Agents; D000975:Antioxidants; D007202:Indicators and Reagents; D017382:Reactive Oxygen Species; D009580:Nitroblue Tetrazolium; D010544:Peroxidases; D054464:Peroxiredoxins; D002374:Catalase; D013482:Superoxide Dismutase; D005978:Glutathione; D001205:Ascorbic Acid; D013307:Streptomycin