[Histopathological changes post cryoablation in canine myocardium].
OBJECTIVE
The purpose of this study was to observe histopathological changes post cryoablation in canine myocardium, to characterize the specific ablation lesion post cryoablation.


METHODS
Cryothermal ablation was applied on myocardium (both epicardium and endocardium) of 14 mongrel dogs with different ablation parameters (-25 degrees C x 4 min, -50 degrees C x 4 min, -75 degrees C x 4 min, -75 degrees C x 2 min, -75 degrees C x 6 min, -75 degrees C x 8 min). Lesion dimensions and histopathologic changes were observed.


RESULTS
The discrete, sharply delimited lesions were detected in cryoablated myocardium. Histologically, cryoablation in all temperatures studied induced heterogeneous necrosis of the myocardium. Lesion dimensions are related to freezing time and temperature.


CONCLUSIONS
Cryoablation is a feasible and preferably choice for clinical application due to its controllable myocardium lesions.
Feng
Jin-zhi
JZ
Department of Cardiology, First People's Hospital, Shanghai Jiaotong University, Shanghai 200080, China.
Wang
Fang
F
Chen
Gang
G
Meng
Wei-dong
WD
Xue
Ji-xiang
JX
Sun
Bao-gui
BG
D000818:Animals; D017115:Catheter Ablation; D003452:Cryosurgery; D004285:Dogs; D004699:Endocardium / Q000473:pathology; D009206:Myocardium / Q000473:pathology*