Urinary zinc excretion is normalized in primary arterial hypertension after perindopril treatment.
Increased or unchanged urinary zinc excretion has been reported in hypertension. In the present article, this observation was confirmed in a group of 10 untreated hypertensive patients of both sexes that had no diabetes or obesity. The 24-h zinc excretion was significantly different between the patients: 7.46+/-3.01 micromol and healthy controls: 5.19+/-2.19 micromol (p<0.025). After a 1-mo treatment with 4 mg perindopril per day, a decrease of urinary zinc was observed until it reached levels not significantly different from those of the healthy controls (5.98 +/- 2.13 micromol). The decrease was significantly different from that of the pretreatment values (p<0.05).
Tubek
Sławomir
S
Faculty of Physical Education and Physiotherapy, Institute of Technology, Opole, Proszkowska 76, Poland. slawomir.tubek@hipokrates.org
D000328:Adult; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000652:urine; D008297:Male; D020913:Perindopril / Q000627:therapeutic use*; D015032:Zinc / Q000652:urine*
D000806:Angiotensin-Converting Enzyme Inhibitors; D015032:Zinc; D020913:Perindopril