[A pharmacology study of Cyclovirobuxinum D on curing myocardial ischemia induced by isoprenaline].
OBJECTIVE
To explore the pharmacology actions of Cyclovirobuxinum D (Cvb-D) for the myocardial ischemia and study its possible mechanism.


METHODS
The rats were given orally with Cvb-D 0.55 g/kg, 1.1 g/kg and 2.2 g/kg per day, for 21 days. The myocardial ischemia model were induced by isoprenaline. The rats ECG, serum CPK, LDH, FFA and myocardium tissue SOD, MDA level were detected.


RESULTS
Cvb-D could significantly reduce myocardial ischemia model induced by isoprenaline rats' sigmaJ of ECG, shorten ECG resume time, reduce serum FFA content, serum CPK, LDH activation, reduce cardiac tissue MDA content, raise the cardiac tissue SOD activation.


CONCLUSIONS
Cvb-D can decrease the release of FFA, CPK, LDH and improve the model rats' myocardium MDA, SOD level. It may be some of mechanisms of its anti-myocardial ischemia effect.
Zhou
Jiu-Yao
JY
Department of Pharmacology, Guangzhou University of TCM, Guangzhou 510405, China.
Liao
Hui-Fang
HF
Huang
Gui-Ying
GY
D000818:Animals; D031234:Buxaceae / Q000737:chemistry*; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D007545:Isoproterenol; D008297:Male; D017202:Myocardial Ischemia / Q000139:chemically induced / Q000188:drug therapy / Q000473:pathology*; D009206:Myocardium / Q000378:metabolism / Q000473:pathology*; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley
D004365:Drugs, Chinese Herbal; C524545:cyclovirobuxinum D; D007545:Isoproterenol