Maximum number of live births per donor in artificial insemination.
BACKGROUND
The maximal number of live births (k) per donor was usually determined by cultural and social perspective. It was rarely decided on the basis of scientific evidence or discussed from mathematical or probabilistic viewpoint.


RESULTS
To recommend a value for k, we propose three criteria to evaluate its impact on consanguinity and disease incidence due to artificial insemination by donor (AID). The first approach considers the optimization of k under the criterion of fixed tolerable number of consanguineous mating due to AID. The second approach optimizes k under fixed allowable average coefficient of inbreeding. This approach is particularly helpful when assessing the impact on the public, is of interest. The third criterion considers specific inheritance diseases. This approach is useful when evaluating the individual's risk of genetic diseases. When different diseases are considered, this criterion can be easily adopted. All these derivations are based on the assumption of shortage of gamete donors due to great demand and insufficient supply.


CONCLUSIONS
Our results indicate that strong degree of assortative mating, small population size and insufficient supply in gamete donors will lead to greater risk of consanguinity. Recommendations under other settings are also tabulated for reference. A web site for calculating the limit for live births per donor is available.
Wang
Charlotte
C
Division of Biostatistics, Institute of Epidemiology, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan.
Tsai
Miao-Yu
MY
Lee
Mei-Hsien
MH
Huang
Su-Yun
SY
Kao
Chen-Hung
CH
Ho
Hong-Nerng
HN
Hsiao
Chuhsing Kate
CK
D003241:Consanguinity; D003550:Cystic Fibrosis / Q000453:epidemiology; D003866:Depressive Disorder / Q000453:epidemiology; D005260:Female; D030342:Genetic Diseases, Inborn / Q000517:prevention & control; D006432:Hemochromatosis / Q000453:epidemiology; D006801:Humans; D007316:Insemination, Artificial, Heterologous / Q000331:legislation & jurisprudence / Q000706:statistics & numerical data*; D008297:Male; D011247:Pregnancy; D018873:Pregnancy Rate; D015995:Prevalence; D011336:Probability; D012559:Schizophrenia / Q000453:epidemiology; D020754:Spinocerebellar Ataxias / Q000453:epidemiology