Microtubule modification: acetylation speeds anterograde traffic flow.
Microtubules in neurites undergo multiple post-translational modifications. Recent work shows that neurites enriched in acetylated microtubules selectively support kinesin-mediated transport of the JNK regulator JIP-1 to growth cones.
Bulinski
J Chloë
JC
Biological Sciences and Pathology & Cell Biology, Columbia University, 804A Sherman Fairchild Center, MC 2450, 1212 Amsterdam Avenue, New York, New York 10027-2450, USA. jcb4@columbia.edu
D000107:Acetylation; D000123:Acetyltransferases / Q000378:metabolism*; D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism*; D000818:Animals; D002460:Cell Line; D016547:Kinesins / Q000378:metabolism; D051379:Mice; D008870:Microtubules / Q000378:metabolism*; D016501:Neurites / Q000378:metabolism*; D011499:Protein Processing, Post-Translational; D013768:Tetrahymena / Q000378:metabolism; D014404:Tubulin / Q000378:metabolism
D048868:Adaptor Proteins, Signal Transducing; C490665:Mapk8ip protein, mouse; D014404:Tubulin; D000123:Acetyltransferases; D016547:Kinesins