Activated alphavbeta3 integrin targeting in injury-induced vascular remodeling.
There is currently no imaging modality to track the remodeling process, a common feature of a broad spectrum of vasculopathies, in vivo. alphavbeta3 Integrin is up-regulated in proliferating vascular cells. RP748, a novel peptidomimetic tracer, binds specifically to the activated alphavbeta3 conformer and exhibits favorable binding characteristics for in vivo imaging. In a model of injury-induced vascular remodeling in apoE null mice, RP748 localization to the injured carotid arteries parallels vascular cell proliferation, providing an opportunity to image the remodeling process in vivo.
Sadeghi
Mehran M
MM
Raymond and Beverly Sackler Cardiovascular Molecular Imaging Laboratory, Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, CT, USA. mehran.sadeghi@yale.edu
Bender
Jeffrey R
JR
D000818:Animals; D006801:Humans; D039302:Integrin alphaVbeta3 / Q000378:metabolism*; D014652:Vascular Diseases / Q000378:metabolism* / Q000473:pathology* / Q000503:physiopathology
D039302:Integrin alphaVbeta3