Actimetric evidence that CLOCK 3111 T/C SNP influences sleep and activity patterns in patients affected by bipolar depression.
Depressive insomnia and diurnal fluctuations of mood and activity are core clinical features of mood disorders. Here we studied the effect of CLOCK 3111 T/C SNP (rs1801260) on the actimetric recorded diurnal activity and nocturnal sleep of 39 bipolar depressed inpatients. Compared to T/T homozygotes, carriers of the C allele had a similar degree of severity of depression, but showed higher activity levels in the evening, a delayed sleep onset (mean 79 min later), and a reduced amount of sleep during the night (mean 75 min less). Ongoing lithium treatment significantly interacted with rs1801260 by enhancing activity levels in the evening and reducing the differences among genotype groups. Individual characteristics of the molecular clock can influence sleep symptoms in mood disorders.
Benedetti
Francesco
F
Department of Neuropsychiatric Sciences, Scientific Institute and University Vita-Salute San Raffaele, Milan, Italy. benedetti.francesco@hsr.it
Dallaspezia
Sara
S
Fulgosi
Mara Cigala
MC
Lorenzi
Cristina
C
Serretti
Alessandro
A
Barbini
Barbara
B
Colombo
Cristina
C
Smeraldi
Enrico
E
D000328:Adult; D000928:Antidepressive Agents / Q000627:therapeutic use; D001683:Biological Clocks; D001714:Bipolar Disorder / Q000188:drug therapy / Q000235:genetics* / Q000523:psychology; D056926:CLOCK Proteins; D002940:Circadian Rhythm / Q000235:genetics*; D003866:Depressive Disorder / Q000188:drug therapy / Q000235:genetics* / Q000523:psychology; D005260:Female; D005838:Genotype; D006801:Humans; D018020:Lithium Compounds / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012890:Sleep; D007319:Sleep Initiation and Maintenance Disorders / Q000235:genetics* / Q000523:psychology; D015534:Trans-Activators / Q000235:genetics*
D000928:Antidepressive Agents; D018020:Lithium Compounds; D015534:Trans-Activators; D056926:CLOCK Proteins; C538943:CLOCK protein, human