title: Evidence for a novel psoriasis susceptibility locus at 9q33-9q34 in Chinese Hans.
abstract: Psoriasis is a heterogeneous disease for which nine linkage loci (PSORS loci 1-5 and PSORS7-10) have been accepted by the Human Genome Nomenclature Committee and an additional 16 potential susceptibility loci have been reported so far. Our previous genome-wide scan in 61 Chinese Han psoriasis vulgaris families found two susceptibility loci at 6p21.3 and 4q31 and additional suggestive linkage evidence at other regions, including 9q33. In this follow-up study, the linkage evidence at 9q33 was further investigated using an expanded sample of 160 families and improved marker coverage. Our follow-up linkage analysis of the 160 families demonstrated strong linkage evidence (P < or = 0.000022) throughout a region between 133.38 and 146.23 cM with a maximum nonparametric linkage (NPL) score of 4.64 (P = 0.00000023) and a heterogeneity LOD (HLOD) score of 5.03 (alpha = 46%) at 142.39 cM near the marker D9S290. By stratifying the 160 families into the subtypes of 130 early-onset and 30 late-onset families, we revealed stronger linkage evidence in the early-onset psoriasis families with a maximum multipoint HLOD score of 6.48 (alpha = 58%) and a maximum NPL score of 4.69 (P = 0.00000012) near marker D9S290. Our follow-up study has confirmed a novel susceptibility locus at 9q33-34 for early-onset psoriasis in the Chinese population.
authors.affiliation: Institute of Dermatology and Department of Dermatology at No.1 Hospital, Anhui Medical University, Hefei, China.
authors.forename: Liang-Dan
authors.initials: LD
authors.lastname: Sun
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.forename: Sen
authors.initials: S
authors.lastname: Yang
authors.forename: Xing
authors.initials: X
authors.lastname: Fan
authors.forename: Kai-Lin
authors.initials: KL
authors.lastname: Yan
authors.forename: Yan-Hua
authors.initials: YH
authors.lastname: Liang
authors.forename: Min
authors.initials: M
authors.lastname: Gao
authors.forename: Yong
authors.initials: Y
authors.lastname: Cui
authors.forename: Feng-Li
authors.initials: FL
authors.lastname: Xiao
authors.forename: Wen-Hui
authors.initials: WH
authors.lastname: Du
authors.forename: Kai-Yue
authors.initials: KY
authors.lastname: Zhang
authors.forename: Wei
authors.initials: W
authors.lastname: Huang
authors.forename: Jian-Jun
authors.initials: JJ
authors.lastname: Liu
authors.forename: Xue-Jun
authors.initials: XJ
authors.lastname: Zhang
mesh_terms: D017668:Age of Onset; D044466:Asian People / Q000208:ethnology / Q000235:genetics*; D002681:China / Q000208:ethnology; D002899:Chromosomes, Human, Pair 9 / Q000235:genetics*; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease / Q000208:ethnology*; D006801:Humans; D008126:Lod Score; D008297:Male; D011565:Psoriasis / Q000208:ethnology* / Q000235:genetics*
chemical_list: D005819:Genetic Markers