Gene therapy for clinical transplantation: where do we stand in 2006?
Gene therapy holds a great promise to prevent allograft rejection or to induce transplant tolerance. Many achievements in vector development have allowed the progression of this therapy to become more attainable in clinical transplantation. In this articles, the authors examine the exciting development in various vector technologies that allows this form of therapy to take the central stage of clinical transplantation. Also highlighted are various therapeutic strategies that might ultimately result in the realization of gene-based treatment in clinical transplantation.
Tan
Peng H
PH
Regional Vascular Unit, Nuffield Department of Surgery, Oxford University, Oxford Radcliffe Hospitals NHS Trust, Headley Way, Oxford, OX3 9DU, UK.
George
Andrew J T
AJ
Handa
Ashok I
AI
D000818:Animals; D015316:Genetic Therapy; D005822:Genetic Vectors / Q000008:administration & dosage / Q000235:genetics; D006801:Humans; D014184:Transplantation, Homologous / Q000379:methods; D014780:Viruses / Q000235:genetics