title: Monosomy 7 as the sole abnormality of an acute basophilic leukemia.
abstract: We report the case of a 72-year-old man who had the very rare disease acute basophilic leukemia with the sole chromosomal finding of a monosomy 7. Most nuclear cells in the peripheral blood and bone marrow samples were either basophils or blasts. The blasts showed negative reaction with myeloperoxidase, periodic acid Schiff, chloroacetate esterase, alpha-naphthyl butyrate esterase, acid phosphatase, and Sudan black B. Metachromatic features of the blasts, however, were observed with toluidine blue stain. Electron microscopic evaluation showed the typical ultrastructure, with basophil and immature mast cell granules. Cytogenetic study revealed monosomy 7 in all metaphase cells, and this finding was confirmed by fluorescence in situ hybridization. The Philadelphia chromosome was absent. Review of the literature revealed abnormalities in cases of ABL. To our knowledge, the case reported here is the first to have basophilic leukemia with monosomy 7 as the only chromosome abnormality.
authors.affiliation: Department of Laboratory Medicine, Chungnam National University Hospital, Daejeon, South Korea.
authors.forename: So Youn
authors.initials: SY
authors.lastname: Shin
authors.forename: Sun Hoe
authors.initials: SH
authors.lastname: Koo
authors.forename: Kye Cheol
authors.initials: KC
authors.lastname: Kwon
authors.forename: Jong Woo
authors.initials: JW
authors.lastname: Park
authors.forename: Chi Seon
authors.initials: CS
authors.lastname: Ko
authors.forename: Deog Yeon
authors.initials: DY
authors.lastname: Jo
mesh_terms: D000368:Aged; D002897:Chromosomes, Human, Pair 7 / Q000235:genetics* / Q000648:ultrastructure; D003937:Diagnosis, Differential; D006801:Humans; D015471:Leukemia, Basophilic, Acute / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology; D008297:Male; D009006:Monosomy / Q000175:diagnosis* / Q000235:genetics* / Q000473:pathology