title: Two cases of ampulla (takotsubo-shaped) cardiomyopathy associated with hemophagocytic lymphohistiocytosis.
abstract: There have been many reports of patients with ampulla cardiomyopathy described as takotsubo-shaped cardiomyopathy in the cardiovascular field. This unique cardiomyopathy is characterized by transient apical ballooning and hypokinesis of the left ventricle. We describe 2 cases of ampulla cardiomyopathy associated with hemophagocytic lymphohistiocytosis (HLH). In both of the patients, ventricular dysfunction suddenly occurred during the active phase of HLH. In each case, the findings on ECG, echocardiogram and left ventriculogram were compatible with ampulla cardiomyopathy. To our knowledge, this communication is the first to report cases of ampulla cardiomyopathy associated with HLH. Our cases suggest that HLH hypercytokinemia may have a role in causing ampulla cardiomyopathy.
authors.affiliation: Clinical Hematology and Clinical Diagnostics, Graduate School of Medicine, Osaka City University, Osaka, Japan. takeoka@med.osaka-cu.ac.jp
authors.forename: Yasunobu
authors.initials: Y
authors.lastname: Takeoka
authors.forename: Mika
authors.initials: M
authors.lastname: Nakamae
authors.forename: Hirohisa
authors.initials: H
authors.lastname: Nakamae
authors.forename: Kiyoyuki
authors.initials: K
authors.lastname: Hagihara
authors.forename: Erina
authors.initials: E
authors.lastname: Sakamoto
authors.forename: Takahiko
authors.initials: T
authors.lastname: Nakane
authors.forename: Hideo
authors.initials: H
authors.lastname: Koh
authors.forename: Ki-Ryang
authors.initials: KR
authors.lastname: Koh
authors.forename: Kensuke
authors.initials: K
authors.lastname: Ohta
authors.forename: Takahisa
authors.initials: T
authors.lastname: Yamane
authors.forename: Masayuki
authors.initials: M
authors.lastname: Hino
mesh_terms: D000368:Aged; D009202:Cardiomyopathies / Q000150:complications* / Q000000981:diagnostic imaging / Q000503:physiopathology; D004452:Echocardiography; D004562:Electrocardiography; D005260:Female; D006801:Humans; D051359:Lymphohistiocytosis, Hemophagocytic / Q000150:complications* / Q000188:drug therapy / Q000503:physiopathology; D008875:Middle Aged; D015899:Tomography, Emission-Computed, Single-Photon