title: [A pharmacology study of Cyclovirobuxinum D on curing myocardial ischemia induced by isoprenaline].
abstract: OBJECTIVE
  To explore the pharmacology actions of Cyclovirobuxinum D (Cvb-D) for the myocardial ischemia and study its possible mechanism.
  
  
  METHODS
  The rats were given orally with Cvb-D 0.55 g/kg, 1.1 g/kg and 2.2 g/kg per day, for 21 days. The myocardial ischemia model were induced by isoprenaline. The rats ECG, serum CPK, LDH, FFA and myocardium tissue SOD, MDA level were detected.
  
  
  RESULTS
  Cvb-D could significantly reduce myocardial ischemia model induced by isoprenaline rats' sigmaJ of ECG, shorten ECG resume time, reduce serum FFA content, serum CPK, LDH activation, reduce cardiac tissue MDA content, raise the cardiac tissue SOD activation.
  
  
  CONCLUSIONS
  Cvb-D can decrease the release of FFA, CPK, LDH and improve the model rats' myocardium MDA, SOD level. It may be some of mechanisms of its anti-myocardial ischemia effect.
authors.affiliation: Department of Pharmacology, Guangzhou University of TCM, Guangzhou 510405, China.
authors.forename: Jiu-Yao
authors.initials: JY
authors.lastname: Zhou
authors.forename: Hui-Fang
authors.initials: HF
authors.lastname: Liao
authors.forename: Gui-Ying
authors.initials: GY
authors.lastname: Huang
mesh_terms: D000818:Animals; D031234:Buxaceae / Q000737:chemistry*; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D007545:Isoproterenol; D008297:Male; D017202:Myocardial Ischemia / Q000139:chemically induced / Q000188:drug therapy / Q000473:pathology*; D009206:Myocardium / Q000378:metabolism / Q000473:pathology*; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D004365:Drugs, Chinese Herbal; C524545:cyclovirobuxinum D; D007545:Isoproterenol