title: [Histopathological changes post cryoablation in canine myocardium].
abstract: OBJECTIVE
  The purpose of this study was to observe histopathological changes post cryoablation in canine myocardium, to characterize the specific ablation lesion post cryoablation.
  
  
  METHODS
  Cryothermal ablation was applied on myocardium (both epicardium and endocardium) of 14 mongrel dogs with different ablation parameters (-25 degrees C x 4 min, -50 degrees C x 4 min, -75 degrees C x 4 min, -75 degrees C x 2 min, -75 degrees C x 6 min, -75 degrees C x 8 min). Lesion dimensions and histopathologic changes were observed.
  
  
  RESULTS
  The discrete, sharply delimited lesions were detected in cryoablated myocardium. Histologically, cryoablation in all temperatures studied induced heterogeneous necrosis of the myocardium. Lesion dimensions are related to freezing time and temperature.
  
  
  CONCLUSIONS
  Cryoablation is a feasible and preferably choice for clinical application due to its controllable myocardium lesions.
authors.affiliation: Department of Cardiology, First People's Hospital, Shanghai Jiaotong University, Shanghai 200080, China.
authors.forename: Jin-zhi
authors.initials: JZ
authors.lastname: Feng
authors.forename: Fang
authors.initials: F
authors.lastname: Wang
authors.forename: Gang
authors.initials: G
authors.lastname: Chen
authors.forename: Wei-dong
authors.initials: WD
authors.lastname: Meng
authors.forename: Ji-xiang
authors.initials: JX
authors.lastname: Xue
authors.forename: Bao-gui
authors.initials: BG
authors.lastname: Sun
mesh_terms: D000818:Animals; D017115:Catheter Ablation; D003452:Cryosurgery; D004285:Dogs; D004699:Endocardium / Q000473:pathology; D009206:Myocardium / Q000473:pathology*