title: Alpha-amino acid Tröger base derivatives, possible conformationally restricted scaffolds?
abstract: The first synthesis of innovative alpha-amino acid conjugates of Tröger base is reported; their potential application as conformationally restricted scaffolds is proposed and has been investigated using high level ab initio calculations.
authors.affiliation: School of Chemical Sciences & Pharmacy, University of East Anglia, Norwich, Norfolk, UK NR4 7TJ. s.bew@uea.ac.uk
authors.forename: Sean P
authors.initials: SP
authors.lastname: Bew
authors.forename: Laurent
authors.initials: L
authors.lastname: Legentil
authors.forename: Vincent
authors.initials: V
authors.lastname: Scholier
authors.forename: Sunil V
authors.initials: SV
authors.lastname: Sharma
mesh_terms: D000596:Amino Acids / Q000138:chemical synthesis / Q000737:chemistry*; D008958:Models, Molecular; D008968:Molecular Conformation; D015394:Molecular Structure; D010455:Peptides / Q000737:chemistry
chemical_list: D000596:Amino Acids; D010455:Peptides