Evidence for distinctive mechanisms of S-nitrosoglutathione metabolism by AdhC in two closely related species, Neisseria gonorrhoeae and Neisseria meningitidis.
The adhC gene from 11 strains of Neisseria gonorrhoeae was distinguished from its homologue in Neisseria meningitidis by the presence of a premature stop codon caused by a single base insertion. Mutational analysis showed that NADH S-nitrosoglutathione oxidoreductase activity was associated with adhC in Neisseria meningitidis but not in Neisseria gonorrhoeae.
Potter
Adam J
AJ
Australian Bacterial Pathogenesis Program, Centre for Metals in Biology, School of Molecular and Microbial Sciences, University of Queensland, Brisbane, QLD 4072, Australia.
Kidd
Stephen P
SP
Jennings
Michael P
MP
McEwan
Alastair G
AG
D000445:Aldehyde Oxidoreductases / Q000235:genetics / Q000502:physiology*; D002384:Catalysis; D009344:Neisseria gonorrhoeae / Q000201:enzymology* / Q000235:genetics; D009345:Neisseria meningitidis / Q000201:enzymology* / Q000235:genetics; D026422:S-Nitrosoglutathione / Q000378:metabolism*
D026422:S-Nitrosoglutathione; C020145:formaldehyde dehydrogenase (glutathione); D000445:Aldehyde Oxidoreductases