Bone formation after sinus augmentation with engineered bone.
OBJECTIVE
The aim of the following investigation was to quantify the resorption rate of tissue-engineered bone grafts in the maxillary sinus using volume measurements.


METHODS
Sinus floor augmentation using autologous bone grafts from the iliac crest (n=17, group 1) was compared with commercially produced transplants of human cells seeded on polyglycolid-polylactid (PLGA) scaffolds (Oral Bone) (n=14, group 2).


RESULTS
The total resorption rate for autologous transplants 3 months post operation was 29%, while the tissue-engineered bone showed a resorption rate of 90%. The autologous bone had a bone density of up to 266-551 Hounsfield units (HU), while sufficient mineralization of tissue-engineered bone was found in only one case (152 HU).


CONCLUSIONS
In this clinical study, the use of autologous cancellous bone grafts in sinus augmentation was more reliable than scaffolds containing cultured osteoblasts. Further tissue-engineered bone transplants should be examined to draw general conclusions about the use of tissue-engineered grafts compared with autologous bone grafts for maxillary sinus augmentation.
Zizelmann
Christoph
C
Department of Oral and Maxillofacial Surgery, University Hospital Freiburg, Freiburg, Germany. c.zizelmann@gmx.de
Schoen
Ralf
R
Metzger
Marc Christian
MC
Schmelzeisen
Rainer
R
Schramm
Alexander
A
Dott
Britta
B
Bormann
Kai-Hendrik
KH
Gellrich
Nils Claudius
NC
D000540:Alveolar Ridge Augmentation / Q000379:methods*; D001672:Biocompatible Materials; D015519:Bone Density / Q000502:physiology; D001862:Bone Resorption / Q000473:pathology; D016025:Bone Transplantation / Q000379:methods* / Q000473:pathology; D003758:Dental Implantation, Endosseous; D015921:Dental Implants; D005500:Follow-Up Studies; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D021621:Imaging, Three-Dimensional / Q000379:methods; D019344:Lactic Acid; D008437:Maxilla / Q000473:pathology / Q000601:surgery*; D008443:Maxillary Sinus / Q000473:pathology / Q000601:surgery*; D010006:Osteoblasts / Q000637:transplantation; D010012:Osteogenesis / Q000502:physiology*; D011100:Polyglycolic Acid; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011108:Polymers; D023822:Tissue Engineering / Q000379:methods*; D014057:Tomography, X-Ray Computed / Q000379:methods; D014182:Transplantation, Autologous
D001672:Biocompatible Materials; D015921:Dental Implants; D011108:Polymers; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid