Coating urinary catheters with an avirulent strain of Escherichia coli as a means to establish asymptomatic colonization.
We investigated whether insertion of urinary catheters that had been coated with Escherichia coli HU2117 could establish bladder colonization with this nonvirulent organism. Ten of 12 subjects were successfully colonized for 14 days or more. The rate of symptomatic UTI during colonization was 0.15 per 100 patient-days.
Trautner
Barbara W
BW
Department of Medicine, Infectious Diseases Section, Center for Prostheses Infection, Michael E. DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas 77030, USA. trautner@bcm.edu
Hull
Richard A
RA
Thornby
John I
JI
Darouiche
Rabih O
RO
D002408:Catheters, Indwelling / Q000382:microbiology*; D002648:Child; D004926:Escherichia coli / Q000254:growth & development*; D005260:Female; D006801:Humans; D001750:Urinary Bladder, Neurogenic / Q000382:microbiology*; D014546:Urinary Catheterization; D014552:Urinary Tract Infections / Q000453:epidemiology / Q000517:prevention & control*