title: Acute recurrent polyhydramnios: a combination of amniocenteses and NSAID may be curative rather than palliative.
abstract: Acute recurrent polyhydramnios is a rare occurrence characterized by a poor fetal outcome. This is a case report describing a 34-year-old woman presenting with acute recurrent polyhydramnios. Treatment with non-steroidal anti-inflammatory drugs (NSAID) and therapeutic amniocenteses was initiated immediately and resulted in a decreased amniotic fluid production from 30 weeks' gestation. Even after the discontinuation of NSAID treatment, the amniotic fluid production normalized, and the woman delivered a healthy boy at 39 weeks 2 days' gestation. Amniotic prolactin was measured at three occasions using an enzyme-linked immunosorbent assay. As in normal pregnancies, amniotic prolactin levels decreased by 80% from highest to lowest value in this case of resolving acute recurrent polyhydramnios.
authors.affiliation: Department of Obstetrics and Gynecology, Copenhagen University Hospital, Copenhagen, Denmark. linerode@dadlnet.dk
authors.forename: Line
authors.initials: L
authors.lastname: Rode
authors.forename: Anne
authors.initials: A
authors.lastname: Bundgaard
authors.forename: Lillian
authors.initials: L
authors.lastname: Skibsted
authors.forename: Lars
authors.initials: L
authors.lastname: Odum
authors.forename: Connie
authors.initials: C
authors.lastname: Jørgensen
authors.forename: Jens
authors.initials: J
authors.lastname: Langhoff-Roos
mesh_terms: D000208:Acute Disease; D000328:Adult; D000649:Amniocentesis / Q000379:methods*; D000653:Amniotic Fluid / Q000378:metabolism; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D006831:Polyhydramnios / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism / Q000628:therapy*; D011247:Pregnancy; D011388:Prolactin / Q000378:metabolism; D011981:Receptors, Prolactin / Q000378:metabolism; D012008:Recurrence
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D011981:Receptors, Prolactin; D011388:Prolactin