Randomized clinical study on the efficacy of a new lacquer for dentine hypersensitivity.
The purpose of this randomized, clinical, double-blind short-term trial was to evaluate the efficacy of a new lacquer containing a new component (phosphonic acid methacrylate) designed for treating dentine hypersensitivity. Eighty-eight patients participated in this study. At the first visit one tooth was treated with the lacquer (1), while another tooth was treated with a placebo (2). Sensitivity levels were determined before treatment as well as after one week. An air blast stimulus and a visual analogue scale were used for evaluation. At baseline, the mean hypersensitivity score of group 1 (53.2+/-26.3) was comparable to the mean hypersensitivity score of the teeth in group 2 (53.3+/-24.4). After one week, a significant reduction of the mean hypersensitivity scores (p <0.001; t-test) was revealed in group 1 (25.8 +/-26.6) as well as in group 2 (26.4+/-25.3). The difference between the two treatment groups was not significant (p = 0.7). There is either no difference between the two treatment modalities or the placebo response and/or the time effect was so strong that the treatment efficacy of the new lacquer was hidden by these effects.
Zantner
Catharina
C
Poliklinik für Zahnerhaltungskunde und Parodontologie, Campus Benjamin Franklin, Charité- Universitätsmedizin, Berlin, Assmannshauserstrasse 4-6, 14197 Berlin, Germany. catharina.zantner@charite.de
Popescu
Odile
O
Martus
Peter
P
Kielbassa
Andrej M
AM
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003804:Dentin / Q000648:ultrastructure; D003807:Dentin Sensitivity / Q000188:drug therapy*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007764:Lacquer; D008297:Male; D008689:Methacrylates / Q000627:therapeutic use*; D008875:Middle Aged; D063065:Organophosphonates / Q000627:therapeutic use*; D009943:Organophosphorus Compounds / Q000627:therapeutic use*; D010147:Pain Measurement
D008689:Methacrylates; D063065:Organophosphonates; D009943:Organophosphorus Compounds