Submucosal glands and goblet cells in maxillary sinus surgery: an experimental study in rabbits.
OBJECTIVE
After sinus surgery poor ciliary activity and disorders in mucus production can lead to an increase in postoperative complications.


OBJECTIVE
To evaluate the changes in the ultrastructure of submucosal glands (SG) and goblet cells (GC) after partial or wide surgical removal of maxillary sinus mucosa (MSM).


METHODS
Twenty New Zealand White rabbits were divided in two groups of 10 animals. In group A, the mucosa of the right maxillary sinus (MS) was removed. In contrast, in group B only a strip the mucosa around the ostium was removed. After three months the sinus were opened and the mucosa studied by light-, and scanning- and transmision electron microscopy.


RESULTS
After three months in group A all right MS were infected with purulent secretions, and the density of SG with a mean value of 10.4 per mm, standard deviation (SD) 3.36 and GC 81.81 per mm (SD: 3.82). However, in group B the SG were 52.3 per mm (SD: 4.5) and GC 4.45 per mm (SD: 1.23). These results were statistically significant (p < 0.001). Histopathological findings showed in group A, after three months, SG with a fewer number of microvilli in the glandular lumen.
Melgarejo-Moreno
P
P
Department of ENT, Santa Maria Hospital, Lleida, Spain. pablomelgarejo@wanadoo.es
Hellín-Meseguer
D
D
D000818:Animals; D005260:Female; D020397:Goblet Cells / Q000648:ultrastructure*; D008443:Maxillary Sinus / Q000601:surgery* / Q000648:ultrastructure; D008854:Microscopy, Electron; D009297:Nasal Mucosa / Q000648:ultrastructure*; D011817:Rabbits; D012038:Regeneration