title: Hypolipidemic and antihyperlipidemic effects of Lagenaria siceraria (Mol.) fruit extracts.
abstract: Bottle gourd [(Lagenaria siceraria (Mol.) Stand.] fruit is ascribed with many therapeutic effects. The present study was undertaken to explore the antihyperlipidemic effect of four different extracts viz. petroleum ether, chloroform, alcoholic and aqueous extracts from bottle gourd in Triton-induced hyperlipidemic rats and their hypolipidemic effects in normocholesteremic rats. The study is comprised preliminary phytochemical screening of the extracts. Oral administration of the extracts, at doses of 200 and 400 mg/kg body weight in rats, dose-dependently inhibited the total cholesterol, triglycerides, low-density lipoproteins level, and significantly increased the high density lipoproteins level. However, petroleum ether extract did not show the significant effects. Both the chloroform and alcoholic extract exhibited more significant effects in lowering total cholesterol, triglycerides and low density lipoproteins along with increase in HDL as compared to the others. Preliminary phytochemical screening revealed the presence of flavonoids, sterols, cucurbitacin saponins, polyphenolics, proteins, and carbohydrates. The results obtained suggest marked antihyperlipidemic and hypolipidemic activity of the extracts.
authors.affiliation: Institute of Pharmaceutical Education and Research, Borgaon (Meghe), Wardha 442 001, India.
authors.forename: B V
authors.initials: BV
authors.lastname: Ghule
authors.forename: M H
authors.initials: MH
authors.lastname: Ghante
authors.forename: A N
authors.initials: AN
authors.lastname: Saoji
authors.forename: P G
authors.initials: PG
authors.lastname: Yeole
mesh_terms: D000818:Animals; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D019662:Cucurbitaceae / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D005638:Fruit / Q000737:chemistry; D006949:Hyperlipidemias / Q000139:chemically induced / Q000188:drug therapy*; D000960:Hypolipidemic Agents / Q000627:therapeutic use*; D008297:Male; D017830:Octoxynol; D010936:Plant Extracts / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014280:Triglycerides / Q000097:blood
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D000960:Hypolipidemic Agents; D010936:Plant Extracts; D014280:Triglycerides; D017830:Octoxynol; D002784:Cholesterol