title: Auto-catalytic ceria nanoparticles offer neuroprotection to adult rat spinal cord neurons.
abstract: This paper describes the evaluation of the auto-catalytic anti-oxidant behavior and biocompatibility of cerium oxide nanoparticles for applications in spinal cord repair and other diseases of the central nervous system. The application of a single dose of nano-ceria at a nano-molar concentration is biocompatible, regenerative and provides a significant neuroprotective effect on adult rat spinal cord neurons. Retention of neuronal function is demonstrated from electrophysiological recordings and the possibility of its application to prevent ischemic insult is suggested from an oxidative injury assay. A mechanism is proposed to explain the auto-catalytic properties of these nanoparticles.
authors.affiliation: NanoScience Technology Center, 12424 Research Parkway, Suite 400, University of Central Florida, Orlando, FL 32826, USA.
authors.forename: Mainak
authors.initials: M
authors.lastname: Das
authors.forename: Swanand
authors.initials: S
authors.lastname: Patil
authors.forename: Neelima
authors.initials: N
authors.lastname: Bhargava
authors.forename: Jung-Fong
authors.initials: JF
authors.lastname: Kang
authors.forename: Lisa M
authors.initials: LM
authors.lastname: Riedel
authors.forename: Sudipta
authors.initials: S
authors.lastname: Seal
authors.forename: James J
authors.initials: JJ
authors.lastname: Hickman
mesh_terms: D000818:Animals; D002384:Catalysis; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D002563:Cerium / Q000008:administration & dosage* / Q000737:chemistry; D002626:Chemistry, Pharmaceutical / Q000379:methods; D053758:Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry / Q000648:ultrastructure; D009416:Nerve Regeneration / Q000187:drug effects*; D009474:Neurons / Q000166:cytology* / Q000187:drug effects*; D018696:Neuroprotective Agents / Q000008:administration & dosage* / Q000737:chemistry; D010316:Particle Size; D051381:Rats
chemical_list: D018696:Neuroprotective Agents; D002563:Cerium; C030583:ceric oxide