Infarct size assessment in mice.
Genetically modified mice are used extensively in models of ischemia reperfusion (I/R) and nonreperfused myocardial infarction (MI) to gain insights into pathways involved in these pathologies. Echocardiography is an ideal noninvasive tool to serially monitor the cardiac murine phenotype. The present review details the surgical aspects of I/R and MI models and the measurement of MI size by pathology techniques and the input of echocardiographic techniques including the extent of wall motion abnormality and of perfusion defects using myocardial contrast echocardiography in the assessment of murine area at risk and MI size.
Scherrer-Crosbie
Marielle
M
Cardiac Ultrasound Laboratory, Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA. marielle@crosbie.com
Rodrigues
Ana Clara T
AC
Hataishi
Ryuji
R
Picard
Michael H
MH
D000818:Animals; D030801:Animals, Genetically Modified; D003287:Contrast Media; D003326:Coronary Circulation; D051379:Mice; D023421:Models, Animal; D009203:Myocardial Infarction / Q000000981:diagnostic imaging* / Q000473:pathology*; D015425:Myocardial Reperfusion; D014463:Ultrasonography
D003287:Contrast Media