Unraveling trafficking of the kidney anion exchanger 1 in polarized MDCK epithelial cells.
Kidney anion exchanger 1 (kAE1) is a membrane glycoprotein expressed at the basolateral membrane of type A intercalated cells in the kidney collecting tubule. Mutations occurring in the gene encoding this protein can give rise to distal renal tubular acidosis (dRTA), a disease characterized by an impaired urine acidification, nephrocalcinosis, and renal failure. Here we review how the study of dRTA mutants in polarized epithelial cells has shed light on the cellular mechanisms resulting in this renal disease.
Cordat
Emmanuelle
E
Department of Biochemistry, University of Toronto, 1 King's College Circle, Toronto, ON M5S 1A8, Canada. emmanuelle.cordat@utoronto.ca
D000818:Animals; D001457:Anion Exchange Protein 1, Erythrocyte / Q000235:genetics* / Q000378:metabolism*; D001693:Biological Transport, Active; D002460:Cell Line; D016764:Cell Polarity; D004285:Dogs; D004847:Epithelial Cells / Q000166:cytology / Q000502:physiology*; D007668:Kidney / Q000166:cytology / Q000378:metabolism*; D008954:Models, Biological
D001457:Anion Exchange Protein 1, Erythrocyte