Assembling a mixed phthalocyanine-porphyrin array in aqueous media through host-guest interactions.
A stable 1:1 host-guest complex is formed between a silicon(IV) phthalocyanine conjugated axially with two permethylated beta-cyclodextrin units and a tetrasulfonated porphyrin. The complex exhibits a light-harvesting property and works as an efficient photosensitizing system, killing HT29 human colon adenocarcinoma cells with an IC50 value of 0.09 microM. [structure: see text].
Leng
Xuebing
X
Department of Chemistry and Center of Novel Functional Molecules, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China.
Choi
Chi-Fung
CF
Lo
Pui-Chi
PC
Ng
Dennis K P
DK
D000230:Adenocarcinoma / Q000188:drug therapy*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D003110:Colonic Neoplasms / Q000188:drug therapy*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007211:Indoles / Q000737:chemistry* / Q000528:radiation effects; D054833:Isoindoles; D008027:Light; D015394:Molecular Structure; D017646:Organosilicon Compounds / Q000138:chemical synthesis* / Q000494:pharmacology / Q000528:radiation effects; D010778:Photochemotherapy / Q000379:methods; D011166:Porphyrins / Q000737:chemistry* / Q000528:radiation effects; D014867:Water / Q000737:chemistry; D047392:beta-Cyclodextrins / Q000737:chemistry / Q000528:radiation effects
D007211:Indoles; D054833:Isoindoles; D017646:Organosilicon Compounds; D011166:Porphyrins; D047392:beta-Cyclodextrins; D014867:Water; C031215:betadex; C013647:phthalocyanine