title: Synthesis of enantiopure chloroalcohols by enzymatic kinetic resolution.
abstract: 3-Alkenyl and heteroaryl chloroalcohols have been obtained in excellent enantiomeric excess (>99%) by enzymatic kinetic resolution using the haloalcohol dehalogenase HheC. Yields were close to the theoretical maximum for all substrates employed. Furthermore, the applicability of this methodology on multigram scale has been established.
authors.affiliation: Department of Organic and Molecular Inorganic Chemistry, Stratingh Institute, University of Groningen, Nijenborgh 4, 9747 AG, Groningen, The Netherlands.
authors.forename: Robert M
authors.initials: RM
authors.lastname: Haak
authors.forename: Chiara
authors.initials: C
authors.lastname: Tarabiono
authors.forename: Dick B
authors.initials: DB
authors.lastname: Janssen
authors.forename: Adriaan J
authors.initials: AJ
authors.lastname: Minnaard
authors.forename: Johannes G
authors.initials: JG
authors.lastname: de Vries
authors.forename: Ben L
authors.initials: BL
authors.lastname: Feringa
mesh_terms: D000438:Alcohols / Q000737:chemistry*; D002384:Catalysis; D002713:Chlorine / Q000737:chemistry*; D002855:Chromatography, Thin Layer; D006867:Hydrolases / Q000737:chemistry; D006868:Hydrolysis; D007700:Kinetics; D008956:Models, Chemical; D008968:Molecular Conformation; D015394:Molecular Structure; D013237:Stereoisomerism; D013696:Temperature
chemical_list: D000438:Alcohols; D002713:Chlorine; D006867:Hydrolases; C113022:haloalcohol dehalogenase