Ever-expanding network of dynamin-interacting proteins.
Clathrin-mediated endocytosis is a major cellular pathway for internalization of proteins and lipids and for recycling of synaptic vesicles. The GTPase dynamin plays a key role in this process, and the proline-rich domain of dynamin participates in various protein-protein interactions to ensure a proper coordination of endocytic processes. Although dynamin is not directly associated with actin, several dynamin-binding proteins can interact with actin or with proteins that regulate actin assembly, thereby coordinately regulating actin assembly and trafficking events. This article summarizes dynamin interactions with various Src homology 3-containing proteins, many of which are actin-binding proteins. It also discusses the recently identified two new dynamin binding proteins, SH3 protein interacting with Nck, 90 kDa/Wiskott-Aldrich syndrome protein interacting with SH3 protein (SPIN90/WISH) and sorting nexin 9, and outlines their potential role as a link between endocytosis and actin dynamics.
Kim
Yoonju
Y
Department of Life Science, Gwangju Institute of Science and Technology (GIST), Gwangju, South Korea.
Chang
Sunghoe
S
D008841:Actin Cytoskeleton / Q000378:metabolism*; D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism; D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism; D002490:Central Nervous System / Q000378:metabolism* / Q000648:ultrastructure; D002966:Clathrin / Q000378:metabolism; D034281:Dynamins / Q000378:metabolism*; D004705:Endocytosis / Q000502:physiology*; D006801:Humans; D008840:Microfilament Proteins / Q000378:metabolism; D009124:Muscle Proteins / Q000378:metabolism; D017729:Presynaptic Terminals / Q000378:metabolism* / Q000648:ultrastructure; D021381:Protein Transport / Q000502:physiology; D058305:Sorting Nexins; D033921:Vesicular Transport Proteins / Q000378:metabolism
D048868:Adaptor Proteins, Signal Transducing; D002352:Carrier Proteins; D002966:Clathrin; D008840:Microfilament Proteins; D009124:Muscle Proteins; C486062:NCKIPSD protein, human; D058305:Sorting Nexins; D033921:Vesicular Transport Proteins; D034281:Dynamins