Molecular determinants of TRP channel assembly.
Calcium channels play important roles in cellular signalling. TRP (transient receptor potential) channels form a superfamily of calcium channels through which Ca(2+) enters the cell. TRPs have six transmembrane segments with a putative pore between the fifth and the sixth segments, and assemble in tetrameric complexes to form functional Ca(2+) channels. They are thus similar to K(V) (voltage-gated potassium channel) channels in terms of structure and molecular determinants that promote subunit assembly. In this review, the molecular determinants mediating the assembly of Drosophila TRP, TRPC (TRP canonical), TRPV (TRP vanilloid) and K(V) channels are described.
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Département de Pharmacologie, Faculté de Médecine et Sciences de la Santé, Université de Sherbrooke, 3001-12e avenue Nord, Sherbrooke, QC, Canada J1H 5N4.
Boulay
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D000818:Animals; D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000378:metabolism; D002454:Cell Differentiation; D003593:Cytoplasm / Q000378:metabolism; D003600:Cytosol / Q000378:metabolism; D004330:Drosophila / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D017434:Protein Structure, Tertiary; D050052:TRPC Cation Channels / Q000737:chemistry*; D050053:TRPM Cation Channels / Q000737:chemistry*; D050916:TRPV Cation Channels / Q000737:chemistry*
D015220:Calcium Channels; D050052:TRPC Cation Channels; D050053:TRPM Cation Channels; D050916:TRPV Cation Channels; D002118:Calcium