Novel synthetic approach toward (+/-)-beta-cuparenone via palladium-catalyzed tandem Heck cyclization of 1-bromo-5-methyl-1-aryl-hexa-1,5-dien-3-ol derivatives.
A novel and convenient synthetic route toward (+/-)-beta-cuparenone and many other sesquiterpene natural product precursors has been developed via palladium-catalyzed tandem Heck cyclization of 1-bromo-5-methyl-1-aryl-hexa-1,5-dien-3-ols. [reaction: see text].
Ray
Devalina
D
Department of Chemistry, Indian Institute of Technology, Kharagpur 721302, India.
Ray
Jayanta K
JK
D000085:Acetates / Q000737:chemistry; D000466:Alkadienes / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D003500:Cyclization; D008024:Ligands; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D012717:Sesquiterpenes / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
D000085:Acetates; D000466:Alkadienes; D008024:Ligands; D012717:Sesquiterpenes; C518007:beta-cuparenone; D010165:Palladium