Small cell lung cancer presenting as a paraneoplastic syndrome characterized by recurrent episodic hypotension and bradycardia: case report.
A 56-year-old man presenting with a 6-month history of recurrent episodic hypotension and bradycardia was found to have limited-stage small cell lung cancer. During both quiescence and episodes of hemodynamic embarrassment, extensive evaluations were conducted. Possible explanations included the following: intermittent great vessel obstruction; baroreceptor failure/hypersensitivity; and autonomic dysfunction. His clinical course favored an antibody-negative dysautonomic paraneoplastic syndrome.
Martin
Mike G
MG
Department of Internal Medicine, Duke University Medical Center, Durham, NC, USA. marti157@mc.duke.edu
Ardati
Amer K
AK
Dunlay
Shannon M
SM
Abernethy
Amy P
AP
Blazing
Michael A
MA
D001919:Bradycardia / Q000209:etiology; D018288:Carcinoma, Small Cell / Q000150:complications* / Q000175:diagnosis*; D003937:Diagnosis, Differential; D006801:Humans; D007022:Hypotension / Q000209:etiology; D008175:Lung Neoplasms / Q000150:complications* / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D010257:Paraneoplastic Syndromes / Q000175:diagnosis* / Q000209:etiology*; D012008:Recurrence