title: Texture analysis of brain MRI evidences the amygdala activation by nociceptive stimuli under deep anesthesia in the propofol-formalin rat model.
abstract: Magnetic resonance images of rat brain were analyzed by texture analysis in order to study the effects of a nociceptive stimulation (formalin test) under propofol deep anesthesia. Changes of the texture in different cerebral brain areas acquired before and after stimulation were checked. Our statistical analysis of texture shows that these changes were present only in the amygdala, in agreement with the facts already known about the unconscious memorization of nociceptive stimuli.
authors.affiliation: Université Strasbourg-Fac de Médecine, F-67000 Strasbourg, France. yu@ipb.u-strasbg.fr
authors.forename: Olivier
authors.initials: O
authors.lastname: Yu
authors.forename: Nathalie
authors.initials: N
authors.lastname: Parizel
authors.forename: Laure
authors.initials: L
authors.lastname: Pain
authors.forename: Blandine
authors.initials: B
authors.lastname: Guignard
authors.forename: Bernard
authors.initials: B
authors.lastname: Eclancher
authors.forename: Yres
authors.initials: Y
authors.lastname: Mauss
authors.forename: Daniel
authors.initials: D
authors.lastname: Grucker
mesh_terms: D000679:Amygdala / Q000033:anatomy & histology* / Q000187:drug effects / Q000502:physiology*; D000758:Anesthesia; D000818:Animals; D001921:Brain / Q000033:anatomy & histology* / Q000187:drug effects / Q000502:physiology*; D005557:Formaldehyde; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009619:Nociceptors / Q000187:drug effects / Q000502:physiology; D010147:Pain Measurement; D015742:Propofol; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D005557:Formaldehyde; D015742:Propofol