Large-scale synthesis of immunoactivating natural product, pristane, by continuous microfluidic dehydration as the key step.
An efficient protocol of dehydration was developed under microfluidic conditions. The method was applied to a multikilogram synthesis of pristane, a biologically important natural product, which is now widely used as an adjuvant for monoclonal antibody production. [reaction: see text].
Tanaka
Katsunori
K
Department of Chemistry, Graduate School of Science, Osaka University, Machikaneyama 1-1, Toyonaka, Osaka 560-0043, Japan.
Motomatsu
Shinya
S
Koyama
Koichi
K
Tanaka
Shin-ichi
S
Fukase
Koichi
K
D001685:Biological Factors / Q000138:chemical synthesis* / Q000737:chemistry; D003681:Dehydration; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation / Q000379:methods*; D015394:Molecular Structure; D012680:Sensitivity and Specificity; D013729:Terpenes / Q000138:chemical synthesis* / Q000737:chemistry
D001685:Biological Factors; D013729:Terpenes; C009042:pristane