title: Ovarian neuroendocrine carcinoma, non-small cell type, associated with serous carcinoma.
abstract: BACKGROUND
  Neuroendocrine carcinoma of the non-small cell type of the ovary is a rare aggressive tumor, interestingly associated with either a surface epithelial tumor or teratoma.
  
  
  METHODS
  A 71-year-old woman presented with a pelvic mass and underwent a total abdominal hysterectomy with a bilateral salpingo-oophorectomy. Pathology examination showed a 6.5 cm in greatest dimension ovarian tumor composed of neuroendocrine carcinoma of the non-small cell type and serous carcinoma. Immunohistochemical studies including keratin 7, WT-1, and neuroendocrine markers demonstrated differences in the two components. Microsatellite instability (MSI) analysis using five polymorphic markers also showed a different pattern in the two components.
  
  
  CONCLUSIONS
  This is the first report of an ovarian neuroendocrine carcinoma, non-small cell type, associated with a serous carcinoma. Immunohistochemistry and MSI are very helpful in making a definite diagnosis.
authors.affiliation: Department of Pathology, Chonnam National University Medical School, 5 Hak-dong, Dong-gu, Gwangju, 501-749, Republic of Korea.
authors.forename: Yoo Duk
authors.initials: YD
authors.lastname: Choi
authors.forename: Ji Shin
authors.initials: JS
authors.lastname: Lee
authors.forename: Chan
authors.initials: C
authors.lastname: Choi
authors.forename: Chang Soo
authors.initials: CS
authors.lastname: Park
authors.forename: Jong Hee
authors.initials: JH
authors.lastname: Nam
mesh_terms: D000368:Aged; D018278:Carcinoma, Neuroendocrine / Q000473:pathology* / Q000601:surgery; D018284:Cystadenocarcinoma, Serous / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D010051:Ovarian Neoplasms / Q000473:pathology* / Q000601:surgery