One-pot preparation of coenzyme A analogues via an improved chemo-enzymatic synthesis of pre-CoA thioester synthons.
Coenzyme A analogues are synthesized in a one-pot preparation by biotransformation of pantothenate thioesters through the simultaneous use of three CoA biosynthetic enzymes, followed by aminolysis.
van Wyk
Marianne
M
Department of Chemistry, Stellenbosch University, Matieland, 7602, South Africa.
Strauss
Erick
E
D000588:Amines / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid; D003065:Coenzyme A / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism*; D003641:Deamination; D004926:Escherichia coli / Q000378:metabolism; D004952:Esters / Q000737:chemistry*; D007700:Kinetics; D015394:Molecular Structure; D013211:Staphylococcus aureus / Q000378:metabolism; D013438:Sulfhydryl Compounds / Q000737:chemistry*
D000588:Amines; D004952:Esters; D013438:Sulfhydryl Compounds; D003065:Coenzyme A