The effects of xerogenic medications on oral mucosa among the Veterans Dental Study participants.
OBJECTIVE
To examine the association of xerogenic medications with the oral mucosa inflammation score (OMS) in US male veterans.


METHODS
The relationship of having the worst 25th percentile in OMS and intake of xerogenic medications with different pharmacologic indications was analyzed by logistic regression, controlling for age in 3 categories (< or =44, 45-64, > or =65), smoking, disease burden index, alcohol abuse, and the duration of medication, in 290 subjects participating in the Veterans Dental Study.


RESULTS
When polypharmacy and denture-wearing status in addition to the aforementioned covariates were controlled, the odds ratios for cardiovascular disease medications and sympathetic agonists were 2.82 (95% confidence interval [CI] 1.35-5.91, P < .006), and 2.96 (CI 1.21-7.26, P < .02), respectively, and those for psychotropics and antihistamines were 2.12 (CI 0.94-4.80, P < .06) and 2.09 (CI 0.80-5.48, P < 0.14), respectively.


CONCLUSIONS
Xerogenic medication may be associated with oral mucosal pathology.
Janket
Sok-Ja
SJ
Department of General Dentistry, Goldman School of Dental Medicine, Boston University, Boston, MA 02118, USA. skjanket@bu.edu
Jones
Judith
J
Rich
Sharron
S
Miller
Donald
D
Wehler
Carolyn J
CJ
Van Dyke
Thomas E
TE
Garcia
Raul
R
Meurman
Jukka H
JH
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002317:Cardiovascular Agents / Q000009:adverse effects; D015986:Confounding Factors, Epidemiologic; D006634:Histamine H1 Antagonists / Q000009:adverse effects; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa / Q000187:drug effects*; D052016:Mucositis / Q000139:chemically induced*; D016017:Odds Ratio; D011619:Psychotropic Drugs / Q000009:adverse effects; D012189:Retrospective Studies; D013280:Stomatitis / Q000139:chemically induced*; D013566:Sympathomimetics / Q000009:adverse effects; D014481:United States; D014728:Veterans; D014987:Xerostomia / Q000139:chemically induced*
D002317:Cardiovascular Agents; D006634:Histamine H1 Antagonists; D011619:Psychotropic Drugs; D013566:Sympathomimetics