A 30-year history of CD4+ vesiculo-bullous mycosis fungoides and multiple visceral malignancies.
An 83-year-old Caucasian woman presented with a 25-year history of an itchy, eczematous blistering eruption affecting her trunk and acral sites. She had a past history of adenocarcinoma of the lung, colorectal carcinoma and bladder carcinoma. Several skin biopsies consistently showed features of a spongiotic process. Direct and indirect immunofluorescence studies were repeatedly negative, excluding the possibility of an autoimmune blistering disorder. A skin biopsy several years later, however, showed histological and immunophenotypic features of mycosis fungoides. The literature on this rare phenotype of cutaneous T-cell lymphoma generally portrays a negative prognosis. Our case illustrates an excellent prognosis with stable disease 30 years after onset.
Pearce
Annette
A
Royal Adelaide Hospital, Department of Dermatology, Adelaide, SA, Australia. annette.pearce@ozemail.com.au
Reid
Catherine
C
Gramp
Amanda
A
Sidhu
Shireen
S
D000230:Adenocarcinoma / Q000150:complications; D000279:Administration, Cutaneous; D000368:Aged; D000369:Aged, 80 and over; D001623:Betamethasone / Q000031:analogs & derivatives / Q000627:therapeutic use; D015704:CD4 Antigens; D002295:Carcinoma, Transitional Cell / Q000150:complications; D015179:Colorectal Neoplasms / Q000150:complications; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications; D009182:Mycosis Fungoides / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D012878:Skin Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D001749:Urinary Bladder Neoplasms / Q000150:complications
D015704:CD4 Antigens; C011175:betamethasone-17,21-dipropionate; D001623:Betamethasone