[The relationship between gene expression of Bcl-2 and Bax and the therapeutic effect in oral cancer patients].
We have investigated the relationship between gene expression of Bcl 2 and Bax and the therapeutic effect in oral cancer patients. A significant correlation between Bcl-2/Bax gene expression ratio in the peripheral blood mononuclear cells (PBMCs) from the patients, and the therapeutic effect of radiation therapy in combination with UFT and OK-432, as well as survival rate, was observed. In addition, the statistically significant correlation was also observed between Bcl-2/Bax ratio and IFN-gamma and NK activity induced with OK-432. These findings suggest that Bcl-2 and Bax gene expression in PBMCs may be useful as a prognostic factor in oral cancer patients.
Oshikawa
Tetsuya
T
Research Institute of Pharmaceutical Sciences, Faculty of Pharmacy, Musashino University.
Okamoto
Masato
M
Ahmed
Sharif Uddin
SU
Tano
Tomoyuki
T
Sato
Mitsunobu
M
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D015870:Gene Expression; D019254:Genes, bcl-2 / Q000235:genetics*; D006801:Humans; D007371:Interferon-gamma / Q000097:blood; D007694:Killer Cells, Natural / Q000166:cytology; D009062:Mouth Neoplasms / Q000235:genetics* / Q000401:mortality / Q000628:therapy*; D010844:Picibanil / Q000008:administration & dosage; D015996:Survival Rate; D005641:Tegafur / Q000627:therapeutic use; D014498:Uracil / Q000627:therapeutic use; D051028:bcl-2-Associated X Protein / Q000235:genetics*
D051028:bcl-2-Associated X Protein; D005641:Tegafur; D010844:Picibanil; D014498:Uracil; D007371:Interferon-gamma