Fluorescent CXCR4 chemokine receptor antagonists: metal activated binding.
The copper(II) complex of a novel rhodamine-azamacrocycle conjugate binds to the CXCR4 chemokine receptor and competes effectively against anti-CXCR4 monoclonal antibodies. The copper macrocycle unit adopts a trans-II configuration in the solid state.
Khan
Abid
A
Department of Chemistry and Institute of Clinical Biosciences, The University of Hull, Cottingham Road, Hull, UK HU6 7RX.
Silversides
Jon D
JD
Madden
Leigh
L
Greenman
John
J
Archibald
Stephen J
SJ
D018360:Crystallography, X-Ray; D005434:Flow Cytometry; D006801:Humans; D019169:Jurkat Cells; D008670:Metals / Q000494:pharmacology*; D008856:Microscopy, Fluorescence / Q000379:methods*; D008958:Models, Molecular; D015394:Molecular Structure; D011485:Protein Binding / Q000187:drug effects; D019718:Receptors, CXCR4 / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000378:metabolism*
D008670:Metals; D019718:Receptors, CXCR4