Combination of tigecycline and N-acetylcysteine reduces biofilm-embedded bacteria on vascular catheters.
To assess the efficacy of an antibiofilm/antimicrobial agent combination, we incubated catheter segments colonized with one of six studied bacterial organisms in N-acetylcysteine, tigecycline, N-acetylcysteine-tigecycline, or saline. Segments were washed, sonicated, and cultured. N-acetylcysteine-tigecycline significantly decreased all viable biofilm-associated bacteria and was synergistic for methicillin-resistant Staphylococcus aureus and Staphylococcus epidermidis.
Aslam
Saima
S
Infectious Disease Section, Department of Medicine, Baylor College of Medicine, and Room 4B-370, Michael E. DeBakey Veterans Affairs Medical Center, 2002 Holcombe Boulevard, Houston, TX 77030, USA. saslam@bcm.tmc.edu
Trautner
Barbara W
BW
Ramanathan
Venkat
V
Darouiche
Rabih O
RO
D000111:Acetylcysteine / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects / Q000254:growth & development; D018441:Biofilms / Q000187:drug effects* / Q000254:growth & development; D002405:Catheterization, Central Venous; D002408:Catheters, Indwelling / Q000382:microbiology*; D004338:Drug Combinations; D024881:Drug Resistance, Bacterial / Q000502:physiology; D004866:Equipment Contamination / Q000517:prevention & control*; D008911:Minocycline / Q000031:analogs & derivatives* / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects / Q000254:growth & development; D013212:Staphylococcus epidermidis / Q000187:drug effects / Q000254:growth & development; D000078304:Tigecycline
D000900:Anti-Bacterial Agents; D004338:Drug Combinations; D000078304:Tigecycline; D008911:Minocycline; D000111:Acetylcysteine