title: Solution-phase parallel synthesis of a library of delta(2)-pyrazolines.
abstract: A parallel synthesis of a library (80 members) of 2-pyrazolines in solution phase is described. The 2-pyrazoline core was accessed through the [3 + 2] cycloaddition of nitrilimines with enoyl oxazolidinones. The cycloaddition provided two regioisomers, the major product being the C regioisomer. The oxazolidinone moiety was further reduced to the primary alcohol, producing another library of 5-hydroxymethyl-2-pyrazolines. The Lipinski profiles and calculated ADME properties of the compounds are also reported.
authors.affiliation: University of Kansas Center of Excellence in Chemical Methodology and Library Development, Lawrence, Kansas 66047, USA.
authors.forename: Shankar
authors.initials: S
authors.lastname: Manyem
authors.forename: Mukund P
authors.initials: MP
authors.lastname: Sibi
authors.forename: Gerald H
authors.initials: GH
authors.lastname: Lushington
authors.forename: Benjamin
authors.initials: B
authors.lastname: Neuenswander
authors.forename: Frank
authors.initials: F
authors.lastname: Schoenen
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Aubé
mesh_terms: D020650:Combinatorial Chemistry Techniques / Q000379:methods; D007097:Imines / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D023303:Oxazolidinones / Q000737:chemistry*; D011720:Pyrazoles / Q000138:chemical synthesis*; D013055:Spectrophotometry, Infrared
chemical_list: D007097:Imines; D023303:Oxazolidinones; D011720:Pyrazoles