Genetic variations of HLA-DRB1 and susceptibility to Kawasaki disease in Taiwanese children.
Although some previous studies have reported that genetic and immunologic factors play important roles in the pathogenesis of Kawasaki disease (KD), the etiologic factors of this enigmatic pediatric disease are still poorly understood. The purpose of this study was to investigate whether polymorphisms of the human leukocyte antigen DRB1 (HLA-DRB1) gene are associated with KD and the development of coronary artery lesions (CAL) in Taiwanese children. Genomic DNA was extracted from whole blood samples from 145 children with KD and 331 healthy controls. The HLA-DRB1 gene was genotyped by polymerase chain reaction (PCR) and sequence-based typing assays. We found that the distribution of HLA-DRB1 allele families and alleles in children with KD did not differ from that in healthy controls. Stratified analysis did not demonstrate any association between particular HLA-DRB1 allele families or alleles and the development of CAL in children with KD. These findings suggest that susceptibility to KD and CAL is not associated with the HLA-DRB1 gene in a Taiwanese population. If immunogenetic determinants are involved in this disease and its complications in Taiwanese children, they must involve genes other than HLA-DRB1.
Huang
Fu-Yuan
FY
Department of Pediatrics, Mackay Memorial Hospital, Taipei, Taiwan.
Chang
Tzu-Yang
TY
Chen
Ming-Ren
MR
Hsu
Chyong-Hsin
CH
Lee
Hung-Chang
HC
Lin
Shuan-Pei
SP
Kao
Hsin-An
HA
Chiu
Nan-Chang
NC
Chi
Hsin
H
Liu
Tiffany Yi-Chen
TY
Liu
Hsin-Fu
HF
Dang
Ching-Wen
CW
Chu
Chen-Chung
CC
Lin
Marie
M
Sung
Tseng-Chen
TC
Lee
Yann-Jinn
YJ
D002648:Child; D002675:Child, Preschool; D003324:Coronary Artery Disease / Q000235:genetics; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006801:Humans; D007223:Infant; D009080:Mucocutaneous Lymph Node Syndrome / Q000235:genetics*; D013624:Taiwan
D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains