title: [Expression and its significance of STAT3, STAT5, Survivin and Ki67 in nasal NK/T cell lymphoma].
abstract: OBJECTIVE
  To study the expression and its significance of STAT3, STAT5, Survivin and Ki67 in the Epstein-Barr virus associated nasal NK/T cell lymphoma.
  
  
  METHODS
  The expression of STAT3, STAT5, Survivin and Ki67 were detected with immunohistochemistry in 25 cases of nasal NK/T cell lymphoma, and their relationship was analyzed. Nasal cavity tissues from 20 cases of chronic sinusitis were as the control group.
  
  
  RESULTS
  The positive rates of STAT3 in the lymphoma and in control group were 56% and 10%, respectively (P <0.01). The positive rates of STAT5 in the lymphoma and in control group were 68% and 15%, respectively (P <0.01). The positive rates of Survivin and Ki67 of nasal NK/T cell-lymphoma were 68% and 72%, respectively; but it in the control group was 0% and 20%, respectively, P <0.01. The expression of STAT3 was positively related to that of Survivin and Ki67(r =0. 428, P <0. 05 and r =0. 704, P <0. 01); The expression of STAT5 was not related to that of Survivin and Ki67.
  
  
  CONCLUSIONS
  The pathway of STAT may play a role in the development of nasal NK/T cell lymphoma. STAT maybe take part in the formation of nasal NK/T cell lymphoma through induction of Survivin and Ki67.
authors.affiliation: Fujian Institute of Otolaryngology, Department of Otolaryngology-Head and Neck Surgery, the First Affiliated Hospital of Fujian Medical University, Fuzhou, 350005, China.
authors.forename: Lihua
authors.initials: L
authors.lastname: Yue
authors.forename: Jinmei
authors.initials: J
authors.lastname: Cheng
authors.forename: Peng fei
authors.initials: Pf
authors.lastname: Zhang
authors.forename: Gongbiao
authors.initials: G
authors.lastname: Lin
authors.forename: Zixiang
authors.initials: Z
authors.lastname: Yi
authors.forename: Rong
authors.initials: R
authors.lastname: Zhang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D004854:Herpesvirus 4, Human; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins; D019394:Ki-67 Antigen / Q000378:metabolism*; D054391:Lymphoma, Extranodal NK-T-Cell / Q000378:metabolism* / Q000473:pathology / Q000821:virology; D008297:Male; D008869:Microtubule-Associated Proteins / Q000378:metabolism*; D008875:Middle Aged; D009669:Nose Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000821:virology; D050796:STAT3 Transcription Factor / Q000378:metabolism*; D050799:STAT5 Transcription Factor / Q000378:metabolism*; D000077022:Survivin; D055815:Young Adult
chemical_list: C107489:BIRC5 protein, human; D051034:Inhibitor of Apoptosis Proteins; D019394:Ki-67 Antigen; D008869:Microtubule-Associated Proteins; D050796:STAT3 Transcription Factor; C494086:STAT3 protein, human; D050799:STAT5 Transcription Factor; C494095:STAT5B protein, human; D000077022:Survivin