A case of recurrent Miller Fisher syndrome mimicking botulism.
Miller Fisher syndrome (MFS) is a rare and usually monophasic polyradiculoneuropathy characterised by ophthalmoplegia, decreased or absent tendon reflexes, and ataxia. The objective of this study was to report a case of recurrent MFS with a clinical presentation virtually indistinguishable from botulism. The patient was a young man with two episodes of increasing external ophthalmoplegia, ptosis, and ataxia with a long asymptomatic interval in between. The second episode occurred after consumption of rotten fish and was accompanied by gastrointestinal symptoms and an anticholinergic syndrome. Very rarely, MFS can present with a recurrent course. The importance of this case of recurrent MFS lies not only in its long asymptomatic period and identical clinical presentation, but also in its instructiveness regarding the differential diagnosis of MFS, particularly life-threatening botulism.
Dörr
J
J
HELIOS Hospital Berlin-Buch, Neurology Department, Hobrechtsfelder Chaussee 96, D-13125 Berlin, Germany. jan-markus.doerr@charite.de
Dieste
F J
FJ
Klaasen van Husen
D
D
Zipp
F
F
Vogel
H P
HP
D000208:Acute Disease; D000328:Adult; D001323:Autoantibodies / Q000097:blood; D001906:Botulism / Q000175:diagnosis*; D003937:Diagnosis, Differential; D004172:Diplopia / Q000175:diagnosis; D005732:Gangliosides / Q000276:immunology; D006801:Humans; D008297:Male; D019846:Miller Fisher Syndrome / Q000175:diagnosis* / Q000276:immunology; D012008:Recurrence
D001323:Autoantibodies; D005732:Gangliosides; C039129:GQ1b ganglioside