title: Evaluation of the clinical effectiveness of the Ventricular Assist Device Program in the United Kingdom (EVAD UK).
abstract: BACKGROUND
  The UK Government funds ventricular assist device (VAD) implantation as bridge to transplantation (BTT) at three centers. Results from this program have not been published.
  
  
  METHODS
  All 70 VAD implants for BTT, 71 inotrope-dependent and 179 non-VAD transplant candidates, accepted for transplantation between April 2002 and December 2004, were prospectively monitored for survival to transplantation, survival overall and quality of life.
  
  
  RESULTS
  Of the 70 VAD patients, 31 (44%) survived to heart transplantation, 4 (6%) were bridged to recovery and 5 remained on support at the end of the study. Thirty patients (43%) died while on support. Overall survival from VAD implant was 52% at 1 year. Ten percent of non-VAD inotrope-dependent patients and 9% of routine transplant candidates died while on the waiting list. For transplant recipients, 12-month post-operative survival was 84%, 85% and 84%, respectively, for VAD, inotrope-dependent and routine transplant candidates. VAD and non-VAD patients had similar post-transplant adverse event rates.
  
  
  CONCLUSIONS
  There was a role for VAD bridge to transplant for selected patients in the UK, despite the availability of an effective urgent transplant list. VAD patients who underwent transplantation had survival rates similar to other transplant candidates.
authors.affiliation: Papworth Hospital NHS Trust, Research and Development, Cambridge, UK. linda.sharples@mrc-bsu.cam.ac.uk
authors.forename: Linda D
authors.initials: LD
authors.lastname: Sharples
authors.forename: Fay
authors.initials: F
authors.lastname: Cafferty
authors.forename: Nickolaos
authors.initials: N
authors.lastname: Demitis
authors.forename: Carol
authors.initials: C
authors.lastname: Freeman
authors.forename: Matthew
authors.initials: M
authors.lastname: Dyer
authors.forename: Nicholas
authors.initials: N
authors.lastname: Banner
authors.forename: Emma J
authors.initials: EJ
authors.lastname: Birks
authors.forename: Asghar
authors.initials: A
authors.lastname: Khaghani
authors.forename: Stephen R
authors.initials: SR
authors.lastname: Large
authors.forename: Steven
authors.initials: S
authors.lastname: Tsui
authors.forename: Noreen
authors.initials: N
authors.lastname: Caine
authors.forename: Martin
authors.initials: M
authors.lastname: Buxton
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D004739:England / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D006333:Heart Failure / Q000401:mortality / Q000601:surgery*; D016027:Heart Transplantation; D006353:Heart-Assist Devices; D006801:Humans; D008297:Male; D008875:Middle Aged; D015397:Program Evaluation; D011446:Prospective Studies; D011788:Quality of Life; D012307:Risk Factors; D015996:Survival Rate / Q000639:trends; D016896:Treatment Outcome