title: Further data on a 9.1-kb insertion-deletion polymorphism: survey of Mediterranean populations.
abstract: We report the distribution of a previously described 9.1-kb insertion-deletion polymorphism located on chromosome 22. We analyzed 1,844 individuals sampled from 26 Mediterranean populations in mainland Italy, Sicily, Sardinia, Tunisia, Libya, Morocco, Egypt, Greece, and Albania. The 9.1 kb - allele is the prevalent allele in the North African (range, 0.53-0.56), Greek (0.51), and Albanian (0.66) populations, whereas the 9.1 kb + allele is most frequent in a mainland Italian town (0.55) and in all Sicilian and Sardinian towns and villages thus far tested, with marked fluctuation ranges of 0.53-0.78 and 0.56-0.80, respectively. In tests for Hardy-Weinberg equilibrium the genotype frequencies observed in Athens and in four of the nine towns in Sicily (but in none of the towns in Sardinia) departed highly significantly from the expected values. Identical results were found in the same towns for a second insertion-deletion polymorphism located on chromosome 22ql13 at a distance compatible with a low incidence of recombination. The data, which are in good agreement with the different histories of the two islands (Sardinia and Sicily), are consistent with a west-east differentiation in Sicily and support the evidence for ancient gene flow from the Iberian peninsula to Sardinia.
authors.affiliation: Dipartimento di Biomorfologia e Biotecnologie, Sezione di Biologia e Genetica, Facoltá di Medicina e Chirurgia, Universitá di Messina, via C. Valeria 1, 98125 Messina, Italy.
authors.forename: Antonella
authors.initials: A
authors.lastname: Sidoti
authors.forename: Renato
authors.initials: R
authors.lastname: Robledo
authors.forename: Antoniettina
authors.initials: A
authors.lastname: Rinaldi
authors.forename: Rosalia
authors.initials: R
authors.lastname: D'Angelo
authors.forename: Carmela
authors.initials: C
authors.lastname: Rinaldi
authors.forename: Aldo
authors.initials: A
authors.lastname: Amato
mesh_terms: D000352:Africa, Northern; D000483:Alleles; D002892:Chromosomes, Human, Pair 22 / Q000235:genetics; D014644:Genetic Variation; D005828:Genetics, Population / Q000379:methods*; D006801:Humans; D019083:Mediterranean Region; D011110:Polymorphism, Genetic