title: Urinary zinc excretion is normalized in primary arterial hypertension after perindopril treatment.
abstract: Increased or unchanged urinary zinc excretion has been reported in hypertension. In the present article, this observation was confirmed in a group of 10 untreated hypertensive patients of both sexes that had no diabetes or obesity. The 24-h zinc excretion was significantly different between the patients: 7.46+/-3.01 micromol and healthy controls: 5.19+/-2.19 micromol (p<0.025). After a 1-mo treatment with 4 mg perindopril per day, a decrease of urinary zinc was observed until it reached levels not significantly different from those of the healthy controls (5.98 +/- 2.13 micromol). The decrease was significantly different from that of the pretreatment values (p<0.05).
authors.affiliation: Faculty of Physical Education and Physiotherapy, Institute of Technology, Opole, Proszkowska 76, Poland. slawomir.tubek@hipokrates.org
authors.forename: Sławomir
authors.initials: S
authors.lastname: Tubek
mesh_terms: D000328:Adult; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000652:urine; D008297:Male; D020913:Perindopril / Q000627:therapeutic use*; D015032:Zinc / Q000652:urine*
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D015032:Zinc; D020913:Perindopril