title: New routes to organofluorine compounds based on ketenes and the radical transfer of xanthates.
abstract: New routes to organofluorine derivatives based mostly on the powerful xanthate radical transfer technology are described. A special emphasis is placed on the synthesis of trifluoromethyl-substituted structures, including trifluromethyl ketones and fluorinated aromatic and heteroaromatic substances of interest to the pharmaceutical and agrochemical industries.
authors.affiliation: Laboratoire de Synthèse Organique, Département de Chimie, Ecole Polytechnique, 91128 Palaiseau, France. zard@poly.polytechnique.fr
authors.forename: Samir Z
authors.initials: SZ
authors.lastname: Zard
mesh_terms: D002264:Carboxylic Acids / Q000737:chemistry; D002621:Chemistry / Q000379:methods; D002625:Chemistry, Organic / Q000379:methods; D002626:Chemistry, Pharmaceutical / Q000379:methods; D005461:Fluorine / Q000737:chemistry*; D017611:Fluorine Compounds / Q000494:pharmacology*; D005609:Free Radicals; D006845:Hydrocarbons, Fluorinated / Q000138:chemical synthesis*; D007202:Indicators and Reagents; D007659:Ketones / Q000737:chemistry; D008956:Models, Chemical; D013678:Technology, Pharmaceutical / Q000379:methods; D013871:Thiones / Q000737:chemistry
chemical_list: D002264:Carboxylic Acids; D017611:Fluorine Compounds; D005609:Free Radicals; D006845:Hydrocarbons, Fluorinated; D007202:Indicators and Reagents; D007659:Ketones; D013871:Thiones; D005461:Fluorine