Generalized, switch-like competitive heterodimerization networks.
High-dimensional switches have been proposed as a way to model cellular differentiation, particularly in the context of basic Helix-Loop-Helix (bHLH) competitive heterodimerization networks. A previous study derived a simple rule showing how many elements can be co-expressed, depending on the rate of competition within the network. A limitation to that rule, however, is that many biochemical parameters were considered to be identical. Here, we derive a generalized rule. This in turns allows one to study more ways in which these networks could be regulated, linking intrinsic cellular differentiation determinants to extracellular cues.
Cinquin
Olivier
O
CoMPLEX, UCL (University College London), Wolfson House, 4 Stephenson Way, London NW1 2HE, UK. cinquin@wisc.edu
Page
Karen M
KM
D051792:Basic Helix-Loop-Helix Proteins / Q000502:physiology*; D002454:Cell Differentiation / Q000502:physiology*; D008954:Models, Biological; D015398:Signal Transduction / Q000502:physiology
D051792:Basic Helix-Loop-Helix Proteins