title: Structure-activity relationship study of the bacterial actin-like protein MreB inhibitors: effects of substitution of benzyl group in S-benzylisothiourea.
abstract: We comprehensively investigated the effects of substitution of the benzyl group in S-benzylisothiourea derivatives on antibacterial activity, because we found previously that some substitutions enhanced it. A 2,4-Cl2-derivative was found to be the most effective compound, it was stronger than the original one in Gram-negative rod shaped-bacteria such as Escherichia coli and Salmonella typhimurium.
authors.affiliation: Department of Bioengineering, Tokyo Institute of Technology, Japan. niwai@bio.titech.ac.jp
authors.forename: Noritaka
authors.initials: N
authors.lastname: Iwai
authors.forename: Takuya
authors.initials: T
authors.lastname: Fujii
authors.forename: Hirokatsu
authors.initials: H
authors.lastname: Nagura
authors.forename: Masaaki
authors.initials: M
authors.lastname: Wachi
authors.forename: Tomoya
authors.initials: T
authors.lastname: Kitazume
mesh_terms: D000199:Actins / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000378:metabolism*; D001426:Bacterial Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D004926:Escherichia coli / Q000187:drug effects / Q000378:metabolism; D015394:Molecular Structure; D012486:Salmonella typhimurium / Q000187:drug effects / Q000378:metabolism; D013329:Structure-Activity Relationship; D013890:Thiourea / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000199:Actins; D001426:Bacterial Proteins; D013890:Thiourea