title: Selection criteria for reduction hepatectomy in multiple advanced hepatocellular carcinoma.
abstract: BACKGROUND
  Few studies have compared the prognostic impact of reduction hepatectomy (RH) for advanced hepatocellular carcinoma (HCC) with that of non-surgical treatment or curative hepatectomy.
  
  
  METHODS
  The treatment outcome of 30 RH patients was compared to that of two control groups: control group A, including 71 patients who underwent curative hepatectomy; control group B, including 106 patients who did not receive definitive local therapy or best supportive care.
  
  
  RESULTS
  In patients with tumor extension in >50% of the liver, 1-year survival rates for patients according to treatment (RH, control A and B) were 50%, 90% and 11% and 3-year survival rates were 42%, 60% and 0%, respectively. There was no significant difference between RH and control A, but there was a significant difference between RH and control B.
  
  
  CONCLUSIONS
  RH could be recommended to patients with multiple advanced HCC extending to >50% of the whole liver.
authors.affiliation: Department of Hepatobiliary Pancreatic Surgery, National Cancer Center Hospital East, Chiba, 277-8577, Japan. ngotohda@east.ncc.go.jp
authors.forename: Naoto
authors.initials: N
authors.lastname: Gotohda
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ishii
authors.forename: Masaru
authors.initials: M
authors.lastname: Konishi
authors.forename: Toshio
authors.initials: T
authors.lastname: Nakagohri
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Takahashi
authors.forename: Junji
authors.initials: J
authors.lastname: Furuse
authors.forename: Masahiro
authors.initials: M
authors.lastname: Yoshino
authors.forename: Taira
authors.initials: T
authors.lastname: Kinoshita
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D006528:Carcinoma, Hepatocellular / Q000473:pathology / Q000601:surgery*; D005260:Female; D006498:Hepatectomy; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D018579:Patient Selection; D016896:Treatment Outcome