title: Association of hypogammaglobulinemia with DRESS (Drug Rash with Eosinophilia and Systemic Symptoms).
abstract: The association of hypogammaglobulinemia was recently reported in anticonvulsant-associated DRESS. Hypogammaglobulinemia could be the consequence of hypoproteinemia in patients with erythroderma. To ascertain the association of hypogammaglobulinemia with DRESS we compared the prevalence of hypogammaglobulinemia in DRESS and in other cause of erythroderma. In a retrospective study, 39 consecutive patients with DRESS were compared to 52 patients with other causes of erythroderma hospitalized in the same period. Hypogammaglobulinemia was statistically significantly associated with DRESS (p = 0.022). This association was not limited to anticonvulsants (phenytoin, carbamazepin) and was observed with other drugs (allopurinol, tazocillin, ibuprofen, celecoxib, vancomycin).
authors.affiliation: Department of Dermatology, Bichat Claude Bernard Hospital, Assistance Publique-Hôpitaux de Paris, 46 rue Henri Huchard, Paris.
authors.forename: Olivia
authors.initials: O
authors.lastname: Boccara
authors.forename: Laurence
authors.initials: L
authors.lastname: Valeyrie-Allanore
authors.forename: Béatrice
authors.initials: B
authors.lastname: Crickx
authors.forename: Vincent
authors.initials: V
authors.lastname: Descamps
mesh_terms: D000361:Agammaglobulinemia / Q000097:blood / Q000150:complications* / Q000453:epidemiology; D001798:Blood Proteins / Q000302:isolation & purification; D004342:Drug Hypersensitivity / Q000097:blood / Q000150:complications*; D004802:Eosinophilia / Q000097:blood / Q000150:complications*; D006801:Humans; D015995:Prevalence; D012016:Reference Values
chemical_list: D001798:Blood Proteins