Enantioselective total synthesis of (+)-gliocladin C.
The first total synthesis of gliocladin C, a fungal-derived marine alkaloid containing a rare trioxopiperazine fragment, is reported. This asymmetric synthesis establishes the absolute configuration of this structurally novel natural product. [reaction: see text].
Overman
Larry E
LE
Department of Chemistry, 1102 Natural Sciences II, University of California, Irvine, California 92697-2025, USA. leoverma@uci.edu
Shin
Youseung
Y
D000470:Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry; D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry; D008968:Molecular Conformation; D010879:Piperazines / Q000138:chemical synthesis* / Q000737:chemistry; D011760:Pyrrolidinones / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
D000470:Alkaloids; D001688:Biological Products; D010879:Piperazines; D011760:Pyrrolidinones; C518056:gliocladin C