title: The changes in angiogenic gene expression in recurrent multiple chorioangiomas.
abstract: OBJECTIVE
  To assess the messenger ribonucleic acid expression in placental tissue of growth factors, cytokines, angiogenic and anti-angiogenic factors in one case of recurrent multiple chorioangiomas.
  
  
  METHODS
  Complementary deoxyribonucleic acid array analysis was performed on the affected placentae and on normal placentaes (controls) to compare messenger ribonucleic acid levels of 96 genes involved in angiogenesis.
  
  
  RESULTS
  Eleven genes presented more than two-fold alteration in expression levels: undetectable (angiopoietin 1, osteonectin, tyrosine kinase endothelial, neuropilin 1), decreased (transcription growth factor beta receptor 3, tissue inhibitor of metalloproteinase type 2, EGF receptor, integrin-alpha V, tyrosine kinase vascular endothelial growth factor receptor 2), increased (angiopoietin 2, osteopontin).
  
  
  CONCLUSIONS
  We illustrated the complexity of angiogenic disruption in recurrent multiple chorioangiomas leading to the difficulty to propose a single candidate gene to explain this pathology.
authors.affiliation: CHU Clermont-Ferrand, Foetal Maternal Medicine Unit, Federation of Gynaecology and Obstetrics, Maternité Hôtel-Dieu, Clermont-Ferrand, France. dgallot@chu-clermontferrand.fr
authors.forename: Denis
authors.initials: D
authors.lastname: Gallot
authors.forename: Geoffroy
authors.initials: G
authors.lastname: Marceau
authors.forename: Hélène
authors.initials: H
authors.lastname: Laurichesse-Delmas
authors.forename: Philippe
authors.initials: P
authors.lastname: Vanlieferinghen
authors.forename: Pierre J
authors.initials: PJ
authors.lastname: Dechelotte
authors.forename: Didier
authors.initials: D
authors.lastname: Lemery
authors.forename: Vincent
authors.initials: V
authors.lastname: Sapin
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D020869:Gene Expression Profiling; D006391:Hemangioma / Q000150:complications / Q000235:genetics* / Q000473:pathology; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D009389:Neovascularization, Pathologic / Q000235:genetics*; D020411:Oligonucleotide Array Sequence Analysis; D010922:Placenta Diseases / Q000235:genetics* / Q000473:pathology; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000235:genetics / Q000473:pathology; D012008:Recurrence