title: Chromium induced contact dermatitis and indices for diagnosis.
abstract: Chromium exposure plays an important role in development of contact dermatitis. The prevalence of contact dermatitis among tannery workers and cement-exposed workers is high. This study was designed to determine the prevalence of contact dermatitis among some Egyptian workers exposed to chromium and to investigate the role of patch test and IgE immunoassay in diagnosis of contact dermatitis. Eighty-three male workers who were exposed to chromium were selected after application of certain exclusion criteria to be the target population of this study. Forty male workers away from exposure to chromium were taken to be the controls. All the exposed and non exposed workers were investigated through an interview questionnaire, clinical examination, patch test and determination of blood and urine chromium levels, absolute eosinophilic count and total IgE level. The results showed that there was no significant difference between exposed workers with clinically diagnosed contact dermatitis and the clinically free exposed workers regarding age and work duration. 7.7% of exposed workers with positive patch test suffered from contact dermatitis while 31.6% of exposed workers with negative patch test suffered from contact dermatitis. There was no statistically significant difference between clinically diagnosed contact dermatitis workers and clinically free workers regarding blood and urine chromium levels. IgE level and absolute eosinophilic count were statistically higher among exposed workers with contact dermatitis than among clinically free exposed workers. According to the results of this study, it is concluded that the diagnosis of skin hypersensitivity to chromium should depend upon the history of chromium exposure, clinical examination and a battery of investigations including IgE level, eosinophilic count and patch test.
authors.affiliation: Occupational Medicine Department, National Research Center.
authors.forename: S
authors.initials: S
authors.lastname: Khalil
authors.forename: A E
authors.initials: AE
authors.lastname: Shouman
authors.forename: S H
authors.initials: SH
authors.lastname: El
authors.forename: E M
authors.initials: EM
authors.lastname: Moussa
mesh_terms: D000395:Air Pollutants, Occupational / Q000009:adverse effects / Q000032:analysis; D016022:Case-Control Studies; D002857:Chromium / Q000097:blood / Q000506:poisoning* / Q000652:urine; D003252:Construction Materials; D003877:Dermatitis, Contact / Q000175:diagnosis* / Q000453:epidemiology / Q000209:etiology* / Q000378:metabolism; D009783:Dermatitis, Occupational / Q000175:diagnosis* / Q000453:epidemiology / Q000209:etiology* / Q000378:metabolism; D004534:Egypt / Q000453:epidemiology; D004784:Environmental Monitoring; D004804:Eosinophils; D062665:Epidemiological Monitoring; D006801:Humans; D007118:Immunoassay; D007073:Immunoglobulin E / Q000097:blood; D007958:Leukocyte Count; D008297:Male; D008487:Medical History Taking; D008875:Middle Aged; D016273:Occupational Exposure / Q000009:adverse effects / Q000032:analysis; D010328:Patch Tests; D010808:Physical Examination; D015995:Prevalence; D011795:Surveys and Questionnaires; D013633:Tanning; D020711:Threshold Limit Values; D013997:Time Factors
chemical_list: D000395:Air Pollutants, Occupational; D002857:Chromium; D007073:Immunoglobulin E