title: Case report of a patient with primary central nervous system lymphoma treated with radioimmunotherapy.
abstract: Primary central nervous system lymphoma (PCNSL) is a rare form of non-Hodgkin lymphoma arising within and confined to the central nervous system and, unlike other primary brain tumors, is very responsive to treatment. Aggressive management can lead to prolonged remissions or cures. However, the prognosis at relapse is generally poor with limited therapeutic options; clearly, new strategies are needed for these patients. Radioimmunotherapy has a growing role in the management of systemic non-Hodgkin lymphoma but has not been evaluated in PCNSL. We report here the first patient with PCNSL treated with radioimmunotherapy.
authors.affiliation: Department of Medicine, Division of Hematology/Oncology, University of Alabama at Birmingham, Comprehensive Cancer Center, AL, USA.
authors.forename: Jatin J
authors.initials: JJ
authors.lastname: Shah
authors.forename: Ruby
authors.initials: R
authors.lastname: Meredith
authors.forename: Sui
authors.initials: S
authors.lastname: Shen
authors.forename: Burt
authors.initials: B
authors.lastname: Nabors
authors.forename: Albert
authors.initials: A
authors.lastname: Lobuglio
authors.forename: Michael
authors.initials: M
authors.lastname: Yester
authors.forename: Andres
authors.initials: A
authors.lastname: Forero
mesh_terms: D000328:Adult; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D001812:Blood-Brain Barrier; D001921:Brain / Q000473:pathology; D016543:Central Nervous System Neoplasms / Q000276:immunology / Q000532:radiotherapy* / Q000628:therapy*; D006801:Humans; D008223:Lymphoma / Q000276:immunology / Q000532:radiotherapy* / Q000628:therapy*; D008228:Lymphoma, Non-Hodgkin / Q000276:immunology / Q000628:therapy; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008727:Methotrexate / Q000627:therapeutic use; D011379:Prognosis; D016499:Radioimmunotherapy / Q000379:methods*; D012074:Remission Induction
chemical_list: D000911:Antibodies, Monoclonal; C422802:ibritumomab tiuxetan; D008727:Methotrexate