title: Synthesis and characterization of cobalt(II), nickel(II), copper(II) and zinc(II) complexes with Schiff base derived from 4-amino-3-mercapto-6-methyl-5-oxo-1,2,4-triazine.
abstract: A few (1:1) and (1:2) metal complexes of cobalt(II), nickel(II), copper(II) and zinc(II) have been isolated with ligand derived from the condensation of 4-amino-3-mercapto-6-methyl-5-oxo-1,2,4-triazine with 2-acetylpyridine (L(1)) and characterized by elemental analysis, conductivity measurements, infrared, electronic, (1)H NMR spectral data, magnetic and thermogravimetric analyses. Due to insolubility in water and most of the common organic solvents and infusibility at higher temperatures, all the complexes are thought to be polymeric in nature. A square-planar geometry was suggested for copper(II) and octahedral proposed for cobalt(II), nickel(II) and zinc(II). Some of the chemically synthesized compounds have been screened in vitro against the three Gram-positive (Staphylococcus aureus, Staphylococcus epidermidis and Bacillus subtilis) and two Gram-negative (Salmonella typhi and Escherichia coli) organisms. It is observed that the coordination of metal ion has pronounced effect on the microbial activities of the ligand. The metal complexes have higher antimicrobial effect than the free ligands.
authors.affiliation: Department of Chemistry, Kurukshetra University, Kurukshetra-136119, Haryana, India.
authors.forename: Kiran
authors.initials: K
authors.lastname: Singh
authors.forename: Manjeet Singh
authors.initials: MS
authors.lastname: Barwa
authors.forename: Parikshit
authors.initials: P
authors.lastname: Tyagi
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003035:Cobalt / Q000737:chemistry; D003300:Copper / Q000737:chemistry; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D007202:Indicators and Reagents; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D008670:Metals / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D009532:Nickel / Q000737:chemistry; D012545:Schiff Bases / Q000138:chemical synthesis*; D013055:Spectrophotometry, Infrared; D013438:Sulfhydryl Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*; D013818:Thermogravimetry; D014227:Triazines / Q000138:chemical synthesis* / Q000494:pharmacology*; D015032:Zinc / Q000737:chemistry
chemical_list: C519546:4-amino-3-mercapto-6-methyl-5-oxo-1,2,4-triazine; D000900:Anti-Bacterial Agents; D007202:Indicators and Reagents; D008024:Ligands; D008670:Metals; D012545:Schiff Bases; D013438:Sulfhydryl Compounds; D014227:Triazines; D003035:Cobalt; D003300:Copper; D009532:Nickel; D015032:Zinc