Insulin-like growth factor-1, leptin, body composition, and clinical status interactions in children with cystic fibrosis.
OBJECTIVE
Children with cystic fibrosis (CF) are of increased risk of reduced fat body mass (FBM) and lean body mass (LBM). Serum concentrations of insulin-like growth factor-1 (IGF-1)and leptin could be markers of LBM and/or FBM depletion. To evaluate the relationships between disease activity, body composition, IGF-1 and leptin concentrations in CF children.


METHODS
A cross-sectional study with 26 CF children aged 5.0-15.5 years and 33 healthy controls, mean age 9.4 years. Body composition was evaluated by dual-energy X-ray absorptiometry. Fasting blood samples were analyzed for leptin, IGF-1 and IGFBP-3.


RESULTS
FBM standard deviation score (SDS; CF boys -0.02 +/- 0.88 vs. 0.78 +/- 0.65, p < 0.01; CF girls -0.37 +/- 1.15 vs. 0.70 +/- 0.97, p < 0.05), leptin concentration (CF boys 2.07 +/- 0.79 vs. 3.07 +/- 1.28 ng/ml, p < 0.05; CF girls 2.71 +/- 0.86 vs. 5.00 +/- 2.95 ng/ml, p < 0.05) and IGF-1SDS (CF boys -1.43 +/- 1.50 vs. -0.32 +/- 0.88, p < 0.05; CF girls -0.66 +/- 1.66 vs. 0.64 +/- 0.57, p < 0.01) were lower in CF children compared to controls. Shwachman score was the strongest predictor of lean body mass (R = 0.63). Leptin levels explain 60% of the variability in FBM.


CONCLUSIONS
Serum concentrations of IGF-1 and leptin are decreased in children with CF and are associated with clinical conditions and body composition.
Boguszewski
Margaret C S
MC
Pediatric Endocrinology Unit, Department of Pediatrics, Hospital de Clínicas, Federal University of Paraná, Curitiba, Brazil. margabogus@bol.com.br
Kamoi
Tsukiyo Obu
TO
Bento Radominski
Rosana
R
Boguszewski
Cesar Luiz
CL
Rosberg
Sten
S
Filho
Nelson Augusto Rosário
NA
Sandrini Neto
Romolo
R
Albertsson-Wikland
Kerstin
K
D000273:Adipose Tissue / Q000033:anatomy & histology; D000293:Adolescent; D015415:Biomarkers / Q000097:blood; D001823:Body Composition; D002648:Child; D002657:Child Development; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D003550:Cystic Fibrosis / Q000097:blood*; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood; D007334:Insulin-Like Growth Factor I / Q000032:analysis*; D020738:Leptin / Q000097:blood*; D008297:Male
D015415:Biomarkers; D020738:Leptin; D007334:Insulin-Like Growth Factor I