Nociception and TRP channels.
Pain is initiated when noxious stimuli excite the peripheral terminals of specialized primary afferent neurons called nociceptors. Many molecules are involved in conversion of the noxious stimuli to the electrical signals in the nociceptor endings. Among them, TRP channels play important roles in detecting noxious stimuli.
Tominaga
M
M
Section of Cell Signaling, Okazaki Institute for Integrative Bioscience, National Institutes of Natural Sciences, 444-8787 Okazaki, Japan. tominaga@nips.ac.jp
D000700:Analgesics / Q000494:pharmacology; D000818:Animals; D006801:Humans; D007249:Inflammation / Q000150:complications / Q000503:physiopathology; D009619:Nociceptors / Q000187:drug effects / Q000502:physiology*; D010146:Pain / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology*; D050051:Transient Receptor Potential Channels / Q000187:drug effects / Q000502:physiology*
D000700:Analgesics; D050051:Transient Receptor Potential Channels