[The modulatory effect of estrogen on the caudal trigeminal nucleus of the rat in an animal model of migraine].
Migraine is one of the most common neurological disorder affecting up to 14% of the population. The disease shows sexual dimorphism, thus gonadal steroids may play an important role in its pathophysiology. One model of migraine headache is the systemic administration of nitric oxide (NO) donor nitroglycerin (NTG), which triggers a delayed attack without aura in many migraine patients but not in healthy volunteers. NTG is also able to activate the neurons of the caudal trigeminal nucleus in the rat. In our review we summarise the effect of NTG on the expression of some molecules, in the superficial laminae of the spinal portion of trigeminal nucleus caudalis, which play an important role in the pathomechanism of headaches, and the modulatory effect of chronic estradiol treatment. Our data show that NTG was able to modify all the examined substances in the caudal trigeminal nucleus, while chronic estradiol treatment abolished this effect. These data may help to understand the mechanisms by which estrogens influence trigeminal nociception and how nitric oxide triggers migraine attacks.
Varga
Hedvig
H
Magyar Tudományos Akadémia-Szegedi Tudományegyetem, Neurológiai Kutatócsoport.
Párdutz
Arpád
A
Tajti
János
J
Vécsei
László
L
Schoenen
Jean
J
D000818:Animals; D015740:Calcitonin Gene-Related Peptide / Q000378:metabolism; D054732:Calcium-Calmodulin-Dependent Protein Kinase Type 2; D017871:Calcium-Calmodulin-Dependent Protein Kinases / Q000378:metabolism; D004195:Disease Models, Animal; D004967:Estrogens / Q000378:metabolism*; D005260:Female; D007150:Immunohistochemistry; D008297:Male; D008881:Migraine Disorders / Q000139:chemically induced / Q000378:metabolism*; D009569:Nitric Oxide / Q000378:metabolism; D020030:Nitric Oxide Donors; D005996:Nitroglycerin; D051381:Rats; D012701:Serotonin / Q000378:metabolism; D014275:Trigeminal Caudal Nucleus / Q000378:metabolism* / Q000503:physiopathology*; D014279:Trigeminal Nucleus, Spinal / Q000378:metabolism / Q000503:physiopathology
D004967:Estrogens; D020030:Nitric Oxide Donors; D009569:Nitric Oxide; D012701:Serotonin; D054732:Calcium-Calmodulin-Dependent Protein Kinase Type 2; D017871:Calcium-Calmodulin-Dependent Protein Kinases; D005996:Nitroglycerin; D015740:Calcitonin Gene-Related Peptide