TRPM3.
TRPM3 is the last identified member of the TRPM subfamily and is most closely related to TRPM1. Due to alternative splicing, the TRPM3 gene encodes a large number of different variants. One splice event, affecting the pore-forming region of the channel, changes its selectivity for divalent cations. In this review, we give an overview of the identified TRPM3 variants and compare their functional properties.
Oberwinkler
J
J
Institut für klinische und experimentelle Pharmakologie und Toxikologie der Universität des Saarlandes, 66421 Homburg, Germany. johannes.oberwinkler@uniklinikum-saarland.de
Phillipp
S E
SE
D000595:Amino Acid Sequence; D000818:Animals; D001711:Biotransformation / Q000187:drug effects; D005786:Gene Expression Regulation / Q000502:physiology; D006801:Humans; D007473:Ion Channels / Q000187:drug effects / Q000378:metabolism / Q000502:physiology; D008969:Molecular Sequence Data; D050053:TRPM Cation Channels / Q000187:drug effects / Q000235:genetics* / Q000502:physiology*
D007473:Ion Channels; D050053:TRPM Cation Channels; C475667:TRPM3 protein, human