The changes in angiogenic gene expression in recurrent multiple chorioangiomas.
OBJECTIVE
To assess the messenger ribonucleic acid expression in placental tissue of growth factors, cytokines, angiogenic and anti-angiogenic factors in one case of recurrent multiple chorioangiomas.


METHODS
Complementary deoxyribonucleic acid array analysis was performed on the affected placentae and on normal placentaes (controls) to compare messenger ribonucleic acid levels of 96 genes involved in angiogenesis.


RESULTS
Eleven genes presented more than two-fold alteration in expression levels: undetectable (angiopoietin 1, osteonectin, tyrosine kinase endothelial, neuropilin 1), decreased (transcription growth factor beta receptor 3, tissue inhibitor of metalloproteinase type 2, EGF receptor, integrin-alpha V, tyrosine kinase vascular endothelial growth factor receptor 2), increased (angiopoietin 2, osteopontin).


CONCLUSIONS
We illustrated the complexity of angiogenic disruption in recurrent multiple chorioangiomas leading to the difficulty to propose a single candidate gene to explain this pathology.
Gallot
Denis
D
CHU Clermont-Ferrand, Foetal Maternal Medicine Unit, Federation of Gynaecology and Obstetrics, Maternité Hôtel-Dieu, Clermont-Ferrand, France. dgallot@chu-clermontferrand.fr
Marceau
Geoffroy
G
Laurichesse-Delmas
Hélène
H
Vanlieferinghen
Philippe
P
Dechelotte
Pierre J
PJ
Lemery
Didier
D
Sapin
Vincent
V
D000328:Adult; D016022:Case-Control Studies; D005260:Female; D020869:Gene Expression Profiling; D006391:Hemangioma / Q000150:complications / Q000235:genetics* / Q000473:pathology; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D009389:Neovascularization, Pathologic / Q000235:genetics*; D020411:Oligonucleotide Array Sequence Analysis; D010922:Placenta Diseases / Q000235:genetics* / Q000473:pathology; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000235:genetics / Q000473:pathology; D012008:Recurrence