title: Association of intradialytic blood pressure changes with hospitalization and mortality rates in prevalent ESRD patients.
abstract: The relationship between blood pressure (BP) and clinical outcomes among hemodialysis patients is complex and incompletely understood. This study sought to assess the relationship between blood pressure changes with hemodialysis and clinical outcomes during a 6-month period. This study is a secondary analysis of the Crit-Line Intradialytic Monitoring Benefit Study, a randomized trial of 443 hemodialysis subjects, designed to determine whether blood volume monitoring reduced hospitalization. Logistic regression was used to estimate the association between BP changes with hemodialysis (Deltasystolic blood pressure=postdialysis-predialysis systoic BP (SBP) and the primary outcome of non-access-related hospitalization and death. Subjects whose systolic blood pressure fell with dialysis were younger, took fewer blood pressure medications, had higher serum creatinine, and higher dry weights. After controlling for baseline characteristics, lab variables, and treatment group, subjects whose SBP remained unchanged with hemodialysis (N=150, DeltaSBP -10 to 10 mm Hg) or whose SBP rose with hemodialysis (N=58, DeltaSBP > or =10 mm Hg) had a higher odds of hospitalization or death compared to subjects whose SBP fell with hemodialysis (N=230, DeltaSBP < or =-10 mm Hg) (odds ratio: 1.85, confidence interval: 1.15-2.98; and odds ratio: 2.17, confidence interval: 1.13-4.15). Subjects whose systolic blood pressure fell with hemodialysis had a significantly decreased risk of hospitalization or death at 6 months, suggesting that hemodynamic responses to dialysis are associated with short-term outcomes among a group of prevalent hemodialysis subjects. Further research should attempt to elucidate the mechanisms behind these findings.
authors.affiliation: Department of Medicine, Duke University Medical Center, Durham, North Carolina 27705, USA. inrig001@mc.duke.edu
authors.forename: J K
authors.initials: JK
authors.lastname: Inrig
authors.forename: E Z
authors.initials: EZ
authors.lastname: Oddone
authors.forename: V
authors.initials: V
authors.lastname: Hasselblad
authors.forename: Barbara
authors.initials: B
authors.lastname: Gillespie
authors.forename: U D
authors.initials: UD
authors.lastname: Patel
authors.forename: D
authors.initials: D
authors.lastname: Reddan
authors.forename: R
authors.initials: R
authors.lastname: Toto
authors.forename: J
authors.initials: J
authors.lastname: Himmelfarb
authors.forename: J F
authors.initials: JF
authors.lastname: Winchester
authors.forename: J
authors.initials: J
authors.lastname: Stivelman
authors.forename: R M
authors.initials: RM
authors.lastname: Lindsay
authors.forename: L A
authors.initials: LA
authors.lastname: Szczech
mesh_terms: D000328:Adult; D000368:Aged; D001794:Blood Pressure; D005260:Female; D006760:Hospitalization; D006801:Humans; D006973:Hypertension / Q000175:diagnosis / Q000209:etiology; D007676:Kidney Failure, Chronic / Q000401:mortality* / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic; D009123:Muscle Hypotonia / Q000175:diagnosis / Q000209:etiology; D006435:Renal Dialysis / Q000009:adverse effects*; D015996:Survival Rate; D016896:Treatment Outcome