What is the alpha2beta1 integrin doing in the epidermis?
The alpha2beta1 integrin is abundantly expressed by basal keratinocytes in intact skin and is required for re-epithelialization of human skin wounds. However, as Grenache et al. and Zweers et al. report, closure of mouse wounds does not require this receptor. The discrepancies between these models may reflect differences in the composition of the dermal matrices and in the proteinases expressed in response to injury.
Parks
William C
WC
Center for Lung Biology, University of Washington, Seattle, Washington 98109, USA. parksw@u.washington.edu
D000818:Animals; D003094:Collagen / Q000378:metabolism; D020405:Dermis / Q000378:metabolism; D004817:Epidermis / Q000378:metabolism / Q000502:physiology*; D005109:Extracellular Matrix / Q000378:metabolism; D006801:Humans; D007113:Immunity, Innate / Q000502:physiology; D038982:Integrin alpha2beta1 / Q000502:physiology*; D020782:Matrix Metalloproteinases / Q000378:metabolism; D051379:Mice; D012867:Skin / Q000276:immunology / Q000293:injuries*; D014945:Wound Healing / Q000502:physiology*
D038982:Integrin alpha2beta1; D003094:Collagen; D020782:Matrix Metalloproteinases