title: The safety and efficacy of the oral rabies vaccine SAG2 in Indian stray dogs.
abstract: India is one of the countries with the highest prevalence of human rabies throughout the world. Dogs are primarily responsible for rabies transmission. Among them, stray dogs play a major role in that country. Parenteral vaccination programmes are insufficient to eliminate rabies partly due to difficulties in establishing satisfactory immunisation coverage in the dog population in view of the high proportion of stray dogs. Oral vaccination may be a useful adjunct to parenteral vaccination by increasing dog vaccination coverage. Safety, immunogenicity and efficacy of Rabidog SAG2 bait were evaluated in Indian stray dogs in captivity. Safety of SAG2 was demonstrated by the absence of adverse clinical sign, salivary excretion and absence of replication of the vaccine strain in brain and salivary glands of 21 vaccinated dogs, even when immunodepressed. Efficacy was shown 109 days post-vaccination after challenge with a highly virulent street rabies virus which killed all five controls whereas all nine vaccinated dogs survived, despite the fact that only five out of nine had seroconverted before challenge.
authors.affiliation: AFSSA, National Research Laboratory on Rabies and Wildlife Diseases, WHO Collaborating Centre for Research and Management in Zoonoses Control, EU Reference Institute for Rabies Serology, Domaine de Pixérécourt, Malzeville, France. f.cliquet@afssa.fr
authors.forename: F
authors.initials: F
authors.lastname: Cliquet
authors.forename: J P
authors.initials: JP
authors.lastname: Gurbuxani
authors.forename: H K
authors.initials: HK
authors.lastname: Pradhan
authors.forename: B
authors.initials: B
authors.lastname: Pattnaik
authors.forename: S S
authors.initials: SS
authors.lastname: Patil
authors.forename: A
authors.initials: A
authors.lastname: Regnault
authors.forename: H
authors.initials: H
authors.lastname: Begouen
authors.forename: A L
authors.initials: AL
authors.lastname: Guiot
authors.forename: R
authors.initials: R
authors.lastname: Sood
authors.forename: P
authors.initials: P
authors.lastname: Mahl
authors.forename: R
authors.initials: R
authors.lastname: Singh
authors.forename: F X
authors.initials: FX
authors.lastname: Meslin
authors.forename: E
authors.initials: E
authors.lastname: Picard
authors.forename: M F A
authors.initials: MF
authors.lastname: Aubert
authors.forename: J
authors.initials: J
authors.lastname: Barrat
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D004285:Dogs; D011819:Rabies Vaccines / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology*; D012449:Safety; D012463:Saliva / Q000821:virology; D014611:Vaccination; D014613:Vaccines, Attenuated / Q000276:immunology
chemical_list: D000914:Antibodies, Viral; D011819:Rabies Vaccines; D014613:Vaccines, Attenuated