Bypassing translation initiation.
A high-resolution cryo-EM reconstruction of a ribosome-bound dicistrovirus IRES (Schüler et al., 2006) and the crystal structure of its ribosome binding domain (Pfingsten et al., 2006) provide new insights into an exceptional eukaryotic translation mechanism.
Hellen
Christopher U T
CU
Department of Microbiology and Immunology, State University of New York Downstate Medical Center, Brooklyn, NY 11203, USA. christopher.hellen@downstate.edu
D020285:Cryoelectron Microscopy; D018360:Crystallography, X-Ray; D010442:Peptide Chain Initiation, Translational; D017434:Protein Structure, Tertiary; D012328:RNA Viruses / Q000737:chemistry / Q000648:ultrastructure; D012333:RNA, Messenger / Q000737:chemistry* / Q000648:ultrastructure; D022661:RNA, Untranslated / Q000737:chemistry / Q000648:ultrastructure; D012270:Ribosomes / Q000737:chemistry* / Q000648:ultrastructure
D012333:RNA, Messenger; D022661:RNA, Untranslated