title: Second lymphomas and other malignant neoplasms in patients with mycosis fungoides and Sezary syndrome: evidence from population-based and clinical cohorts.
abstract: OBJECTIVE
  To assess risks for developing second malignancies in patients with mycosis fungoides or Sézary syndrome.
  
  
  METHODS
  Retrospective study of 2 cohorts.
  
  
  METHODS
  Nine population-based US cancer registries that constitute the Surveillance, Epidemiology, and End Results Program (SEER-9), and Stanford University referral center cohort of patients with cutaneous lymphoma. Patients with mycosis fungoides or Sézary syndrome from the SEER-9 registry diagnosed and followed up from 1984 through 2001 and from the Stanford University cohort diagnosed and followed up from 1973 through 2001.
  
  
  METHODS
  Relative risk was estimated using the standardized incidence ratio (SIR). The expected cancer incidence for both cohorts was calculated using age-, sex-, race-, and calendar year-specific SEER-9 incidence rates for the general population. Nonmelanoma skin cancers were excluded because these cancers are not routinely reported by the SEER database.
  
  
  RESULTS
  In the SEER-9 cohort (n = 1798), there were 197 second instances of cancer (SIR = 1.32; 95% confidence interval [CI], 1.15-1.52) at all sites. Significantly elevated risk (P<.01) was observed for Hodgkin disease (6 cases; SIR = 17.14; 95% CI, 6.25-37.26) and non-Hodgkin lymphoma (27 cases; SIR = 5.08; 95% CI, 3.34-7.38). Elevated risk (P<.05) was also observed for melanoma (10 cases; SIR = 2.60; 95% CI, 1.25-4.79), and urinary cancer (21 cases; SIR = 1.74; 95% CI, 1.08-2.66). In the Stanford University cohort (n = 429), there were 37 second instances of cancer (SIR = 1.04; 95% CI, 0.76-1.44). Elevated risk (P<.01) was observed for Hodgkin disease (3 cases; SIR = 27.27; 95% CI, 5.35-77.54). Elevated risk (P<.05) was also observed for biliary cancer (2 cases; SIR = 11.76; 95% CI, 1.51-42.02).
  
  
  CONCLUSIONS
  Updated SEER (population based) and Stanford (clinic based) data confirm the generalizability of earlier findings of increased risk of lymphoma in patients with mycosis fungoides or Sézary syndrome.
authors.affiliation: Department of Dermatology, Stanford University School of Medicine, Stanford, CA 94305, USA.
authors.forename: Kathie P
authors.initials: KP
authors.lastname: Huang
authors.forename: Martin A
authors.initials: MA
authors.lastname: Weinstock
authors.forename: Christina A
authors.initials: CA
authors.lastname: Clarke
authors.forename: Alex
authors.initials: A
authors.lastname: McMillan
authors.forename: Richard T
authors.initials: RT
authors.lastname: Hoppe
authors.forename: Youn H
authors.initials: YH
authors.lastname: Kim
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001650:Bile Duct Neoplasms / Q000175:diagnosis; D002648:Child; D015331:Cohort Studies; D019317:Evidence-Based Medicine; D005260:Female; D006689:Hodgkin Disease / Q000175:diagnosis; D006801:Humans; D015994:Incidence; D008223:Lymphoma / Q000175:diagnosis* / Q000453:epidemiology; D008228:Lymphoma, Non-Hodgkin / Q000175:diagnosis; D008297:Male; D008545:Melanoma / Q000175:diagnosis; D008875:Middle Aged; D009182:Mycosis Fungoides / Q000175:diagnosis* / Q000453:epidemiology; D016609:Neoplasms, Second Primary / Q000175:diagnosis* / Q000453:epidemiology; D012042:Registries; D012189:Retrospective Studies; D018570:Risk Assessment; D018426:SEER Program; D012751:Sezary Syndrome / Q000175:diagnosis* / Q000453:epidemiology; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000453:epidemiology; D014481:United States / Q000453:epidemiology