title: Neuropharmacological activity of Eupatorium buniifolium aqueous extract in mice.
abstract: The aim of this study was to evaluate the neuropharmacological profile of the Eupatorium buniifolium aqueous extract (EB) in mice. EB at doses up to 1.5 g/kg p.o. of the lyophilized material produced a dose dependent sleep induction and potentiation of sub-hypnotic and hypnotic doses of pentobarbital, respectively. However, EB neither modified the spontaneous motor activity nor produced a myorelaxant effect. Moreover, EB 1.5 g/kg in a nose-poke habituation task, produced a disruption of the normal patterns of habituation, and in a step-down inhibitory avoidance task, induced an amnesic effect similar to diazepam. These results suggest that the activity of EB may be a CNS-depressant.
authors.affiliation: Cátedra de Farmacología, Departamento de Farmacología, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Junín 956 (1113AAD), Buenos Aires, Argentina.
authors.forename: Jorge
authors.initials: J
authors.lastname: Miño
authors.forename: Liliana
authors.initials: L
authors.lastname: Muschietti
authors.forename: Graciela
authors.initials: G
authors.lastname: Ferraro
authors.forename: Virginia
authors.initials: V
authors.lastname: Martino
authors.forename: Cristina
authors.initials: C
authors.lastname: Acevedo
mesh_terms: D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D036602:Eupatorium; D005260:Female; D006185:Habituation, Psychophysiologic / Q000187:drug effects; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D009420:Nervous System / Q000187:drug effects*; D010936:Plant Extracts / Q000494:pharmacology*; D012890:Sleep / Q000187:drug effects
chemical_list: D010936:Plant Extracts