title: Vascular erosion by central venous catheters used for total parenteral nutrition.
abstract: OBJECTIVE
  To establish the incidence of central venous catheter erosion in a patient cohort receiving total parenteral nutrition and to examine risk factors and complications of vascular erosion.
  
  
  METHODS
  Review of prospectively collected intravenous nutrition service audit records in a tertiary university hospital.
  
  
  RESULTS
  Records of 1,499 patients (2,992 catheters) were studied over the 14 year period 1991-2005. Fisher's exact test was used to determine statistical significance. Five erosions occurred, representing an incidence of 0.17% per catheter or 0.28 per 1,000 catheter days. One of the five patients died from ensuing complications. Mean time to onset of symptoms was 3.6 days following catheter insertion. Symptoms/signs included dyspnoea (n=5), chest pain (n=2) and pleural effusion (n=5). Diagnosis was delayed by a mean of 1.6 days. Three erosions occurred in left subclavian catheters (n=583); two in left internal jugular catheters (n=453). None occurred in right-sided catheters (n=1956). The relative risk of erosion occurring in left-sided catheters compared to right was 2.9 (95% CI 2.76-3.00; p=0.009). There was no statistically significantly greater risk of vascular erosion in subclavian than internal jugular catheters (relative risk 0.9; p=1.0). Older age was a statistically significant risk factor (p=0.009); female sex was not (p=0.18).
  
  
  CONCLUSIONS
  In patients receiving total parenteral nutrition via central venous catheters, erosion has an incidence per catheter of 0.17% and is more likely to occur in left-sided catheters and elderly patients.
authors.affiliation: Department of Intensive Care, Mater Misericordiae University Hospital, Eccles Street, Dublin 7, Ireland. crionawalshe@gmail.com
authors.forename: Criona
authors.initials: C
authors.lastname: Walshe
authors.forename: Dermot
authors.initials: D
authors.lastname: Phelan
authors.forename: Jane
authors.initials: J
authors.lastname: Bourke
authors.forename: Donal
authors.initials: D
authors.lastname: Buggy
mesh_terms: D000368:Aged; D002405:Catheterization, Central Venous / Q000009:adverse effects* / Q000295:instrumentation / Q000379:methods; D002408:Catheters, Indwelling; D005119:Extravasation of Diagnostic and Therapeutic Materials / Q000209:etiology*; D005260:Female; D006801:Humans; D007601:Jugular Veins / Q000293:injuries*; D008297:Male; D008875:Middle Aged; D010289:Parenteral Nutrition, Total / Q000009:adverse effects*; D012189:Retrospective Studies; D012307:Risk Factors; D012421:Rupture; D013350:Subclavian Vein / Q000293:injuries*