title: An experimentally antithrombotic strawberry variety is also effective in humans.
abstract: Prevention of arterial thrombotic diseases is of high priority in developed countries. As inappropriate diet is regarded as an important risk factor of thrombotic events, daily intake of an antithrombotic diet may offer a convenient and effective way of prevention. Earlier we used animal models of thrombosis to find fruits and vegetables with potential antithrombotic activity. Among various strawberry varieties tested, a particular variety (KYSt-4, Nohime) showed a significant antithrombotic effect. The aim of the present investigation was to extend this study to humans, by testing the experimentally active KYSt-4 and inactive KYSt-10 variety for effectiveness in humans after oral intake. Filtrates of strawberries were prepared and administered orally. Thrombotic status was tested by a novel global test (Gorog Thrombosis Test). The strawberry variety (KYSt-4; Nohime) which earlier inhibited experimental thrombosis showed antithrombotic effects in humans, while the experimentally inactive variety (KYSt-10) as well as the relevant control (water) were ineffective.
authors.affiliation: Laboratory of Physiology, Faculty of Nutrition, Kobe Gakuin University, Nishi-ku, Kobe, Japan.
authors.forename: Aki
authors.initials: A
authors.lastname: Naemura
authors.forename: Hideo
authors.initials: H
authors.lastname: Ohira
authors.forename: Masamichi
authors.initials: M
authors.lastname: Ikeda
authors.forename: Kaneyuki
authors.initials: K
authors.lastname: Koshikawa
authors.forename: Hiromitsu
authors.initials: H
authors.lastname: Ishii
authors.forename: Junichiro
authors.initials: J
authors.lastname: Yamamoto
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000494:pharmacology*; D001780:Blood Coagulation Tests; D004032:Diet; D005260:Female; D005343:Fibrinolytic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D031985:Fragaria / Q000737:chemistry*; D006801:Humans; D008163:Luminescent Measurements; D008297:Male; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats
chemical_list: D000975:Antioxidants; D005343:Fibrinolytic Agents; D010936:Plant Extracts