[Neonatal treatment effect with selective inhibitor of 5-HT recapture on [corrected] the cranium-encephalic anatomic development].
Neonatal repercussion researched of the serotonin selective recapture inibitor (SSRI) chronic treatment about the somatic growth, of the encephalon and skull. Male rats were divided into groups: control (NaCl) and Cit (10 microL/Kg citalopram 10 mg). In 21 post birth days were measured body weight, side axle , front and rear and skull circle. At 8, 15, 22 days after birth, animals were sacrified for the encephalon withdrawal to evaluate the measurements mentioned above. SSRI use caused body growth deficit, skull and encephalon reduction. The retard is possibly caused by the magnitude change of the trophic serotonin action over the skull-facial morphogenesis, reinforcing the serotoninergic system participation over the somatic and ontogenic growth. The SSRI possible hypophagic effects are not discarded.
Magalhães
Carolina Peixoto
CP
Universidade Federal de Pernambuco, Recife, PE, Brasil.
de Lima
Luciene Oliveira
LO
da Silva
Matilde Cesiana
MC
Marinho
Sônia Maria Oliveira Cavalcanti
SM
do Nascimento
Elizabeth
E
da Silva
Cristiano Mendes
CM
de Souza
Sandra Lopes
SL
Manhães-de-Castro
Raul
R
D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000187:drug effects / Q000254:growth & development*; D015283:Citalopram / Q000494:pharmacology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D017367:Selective Serotonin Reuptake Inhibitors / Q000494:pharmacology*; D012886:Skull / Q000187:drug effects / Q000254:growth & development*
D015283:Citalopram; D017367:Selective Serotonin Reuptake Inhibitors