Tissue-polypeptide-specific antigen levels in diabetic patients with normal and pathological biochemical profiles.
OBJECTIVE
To identify causes for the raised TPS levels seen in diabetic patients.


METHODS
Relationships between TPS levels and biochemical markers for glycaemic control, hepatic dysfunction and renal dysfunction were investigated in 402 diabetic patients, none with evidence of cancer.


RESULTS
Median TPS level (range) was 34.6 (19-276) U/L in controls versus 40.5 (16-691) U/L in type 1 diabetes mellitus (T1DM) patients and 53 (6-1654) U/L in type 2 diabetes mellitus (T2DM) patients. TPS levels above the 95th percentile were observed in 26.1% diabetic patients and in 68.6% of these diabetic patients, raised TPS was associated with clinical complications or biochemical indicators of hepatic and/or renal dysfunction.


CONCLUSIONS
The raised mean TPS levels seen in diabetic patients appear to be mainly due to the existence of hepatic or renal dysfunction.
Rodriguez
Javier
J
Department of Biochemistry and Molecular Biology, University of Santiago de Compostela, Spain.
Varela-Calviño
Rubén
R
Garrido Outeiriño
Manuel
M
Rodríguez-Segade
Santiago
S
Camiña
Felix
F
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000150:complications*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D005260:Female; D006801:Humans; D007668:Kidney / Q000503:physiopathology; D007674:Kidney Diseases / Q000175:diagnosis* / Q000209:etiology; D008099:Liver / Q000503:physiopathology; D008107:Liver Diseases / Q000175:diagnosis* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D010455:Peptides / Q000097:blood*
D015415:Biomarkers; D001786:Blood Glucose; D010455:Peptides; C089984:tissue polypeptide specific antigen