Golgi biogenesis in simple eukaryotes.
The accurate duplication of cellular organelles is important to ensure propagation through successive generations. The semi-conserved replication of DNA and DNA-containing organelles has been well studied, but the mechanisms used to duplicate most other organelles remain elusive. These include the centrosomes, which act as microtubule organizing centres during interphase and orient the mitotic spindle poles during mitosis. Centrosomes can also act as basal bodies, nucleating the growth of cilia or flagella. Even less understood are the mechanisms used to duplicate membrane-bound organelles that do not contain DNA. These include organelles involved in the secretory pathway such as the endoplasmic reticulum and the Golgi apparatus. This review will summarize the current knowledge of Golgi biogenesis in simple eukaryotic organisms, in particular, two protozoan parasites, Toxoplasma gondii and Trypanosoma brucei.
He
Cynthia Y
CY
Department of Cell Biology, Ludwig Institute for Cancer Research, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520-8002, USA. cynthia.he@yale.edu
D000818:Animals; D005057:Eukaryotic Cells / Q000378:metabolism*; D006056:Golgi Apparatus / Q000378:metabolism*; D008954:Models, Biological; D014122:Toxoplasma / Q000378:metabolism; D014346:Trypanosoma brucei brucei / Q000378:metabolism