title: Treatment of recurrent clear cell sarcoma of the kidney with brain metastasis.
abstract: BACKGROUND
  Clear cell sarcoma of the kidney (CCSK) is known for its propensity to metastasize to bone, but it also spreads to other sites including the brain. This study was undertaken to describe the treatment and outcomes of patients with recurrent CCSK involving the brain.
  
  
  METHODS
  A retrospective records review was conducted on eight patients with CCSK who developed brain metastases after complete responses to initial therapy.
  
  
  RESULTS
  The recurrences occurred at a median of 24.5 months after initial diagnosis (range, 12-53 months). At the time of recurrence, patients were treated with multimodal therapy including biopsy or resection, radiation therapy, and chemotherapy. All patients received a variable number of courses of ifosfamide, carboplatin, and etoposide (ICE), with or without other agents. Four patients received high-dose chemotherapy with autologous stem cell rescue. One patient died from complications of bacteremia 8 weeks after starting chemotherapy. The other seven patients achieved a complete response after either surgery or ICE chemotherapy. Of these, six patients were alive without disease with a median follow-up of 30 months from the time of recurrence (range, 24 to 71 months). All six survivors received radiation therapy and four had gross total resections. Three survivors received high-dose chemotherapy with stem cell rescue.
  
  
  CONCLUSIONS
  Patients with recurrent CCSK involving the brain can have durable survival after recurrence. ICE chemotherapy, together with radiation therapy and surgery, provides a reasonable salvage regimen for recurrent CCSK. It is unclear whether high-dose chemotherapy confers a benefit compared to conventional-dose chemotherapy.
authors.affiliation: East Tennessee State University, Johnson City, Tennessee, USA.
authors.forename: Vlad C
authors.initials: VC
authors.lastname: Radulescu
authors.forename: Mary
authors.initials: M
authors.lastname: Gerrard
authors.forename: Chris
authors.initials: C
authors.lastname: Moertel
authors.forename: Paul E
authors.initials: PE
authors.lastname: Grundy
authors.forename: Liesl
authors.initials: L
authors.lastname: Mathias
authors.forename: James
authors.initials: J
authors.lastname: Feusner
authors.forename: Lisa
authors.initials: L
authors.lastname: Diller
authors.forename: Jeffrey S
authors.initials: JS
authors.lastname: Dome
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D001932:Brain Neoplasms / Q000556:secondary* / Q000628:therapy*; D002675:Child, Preschool; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007223:Infant; D007680:Kidney Neoplasms / Q000473:pathology / Q000628:therapy*; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000628:therapy*; D009367:Neoplasm Staging; D012189:Retrospective Studies; D018227:Sarcoma, Clear Cell / Q000556:secondary* / Q000628:therapy*; D016896:Treatment Outcome