Morphine and its metabolites: analytical methodologies for its determination.
The present article reviews the methods of determination published for morphine and its metabolites covering the period from 1980 until at the first part of 2006. The overview includes the most relevant analytical determinations classified in the following two types: (1) non-chromatographic methods and (2) chromatographic methods.
Bosch
M Espinosa
ME
Department of Analytical Chemistry, Faculty of Sciences, University of Málaga, Campus Teatinos, 29071 Málaga, Spain.
Sánchez
A Ruiz
AR
Rojas
F Sánchez
FS
Ojeda
C Bosch
CB
D000701:Analgesics, Opioid / Q000032:analysis* / Q000493:pharmacokinetics; D000818:Animals; D001711:Biotransformation; D002849:Chromatography, Gas; D002851:Chromatography, High Pressure Liquid; D020374:Chromatography, Micellar Electrokinetic Capillary; D019075:Electrophoresis, Capillary; D006801:Humans; D009020:Morphine / Q000032:analysis* / Q000493:pharmacokinetics
D000701:Analgesics, Opioid; D009020:Morphine