Necrobiotic xanthogranuloma successfully treated with autologous stem cell transplantation.
Paraproteinemia can be complicated by necrobiotic xanthogranuloma. Therapeutic options for this progressive disease are limited, and there is no agreement on a single best strategy. We report the case of a patient with a massive periorbital infiltration narrowing the palpebral fissure and blinding the patient. Conventional myeloma therapy had only limited benefit in our patient. However, he was successfully treated with high-dose chemotherapy followed by autologous stem cell transplantation, rendering the patient free of symptoms. This is the first report of autologous stem cell transplantation in a patient with necrobiotic xanthogranuloma.
Goede
Jeroen S
JS
Misselwitz
Benjamin
B
Taverna
Christian
C
Schanz
Urs
U
Dispenzieri
Angela
A
Hummel
Yvonne
Y
Trüeb
Ralph M
RM
Fehr
Jörg
J
D000328:Adult; D006801:Humans; D008297:Male; D017441:Necrobiotic Disorders / Q000473:pathology / Q000601:surgery*; D012871:Skin Diseases / Q000473:pathology / Q000601:surgery*; D033581:Stem Cell Transplantation / Q000379:methods*; D014182:Transplantation, Autologous; D016896:Treatment Outcome