Battle for survival: interplay between pathogenic mycobacteria and the host immune system.
Mycobacteria tuberculosis infects about one third of the world population in their life times and causes millions of deaths each year. M. tuberculosis has a unique capability to circumvent the bactericidal activities of macrophages - the frontline defenders of the host immunity. New understanding of this mechanism has positioned scientists to develop therapies that allow host immune system to gain an upper hand.
Nguyen
Liem
L
Biozentrum, University of Basel, Klingelbergstrasse 70, 4056 Basel, Switzerland.
Pieters
Jean
J
D000818:Animals; D006801:Humans; D008264:Macrophages / Q000276:immunology / Q000382:microbiology; D009161:Mycobacterium / Q000276:immunology*; D009164:Mycobacterium Infections / Q000276:immunology*; D009169:Mycobacterium tuberculosis / Q000276:immunology; D010587:Phagocytosis / Q000235:genetics / Q000502:physiology; D010588:Phagosomes / Q000276:immunology / Q000378:metabolism; D014714:Vertebrates / Q000276:immunology* / Q000382:microbiology*