title: [Subacute cutaneous lupus erythematosus in childhood: a case report].
abstract: Subacute cutaneous lupus erythematosus is extremely rare in childhood. We report the case of a 7 year-old girl who presented annular erythematous infiltrated lesions on sun exposed areas since the age of 2 months. Histopathologic examination showed orthohyperkeratosis, epidermal atrophy, widespread hydropic degeneration of epidermal basal cell layer, and a dermal lymphohistiocytic infiltrate. The lupus band test was negative. The immunological investigations (antinuclear antibodies) were negative. Treatment with antimalarials, topical steroids and sun protection allowed clearance of the cutaneous lesions. Lesions relapsed after antimalarials discontinuation and sun exposure. Four years later, at the age of 11, the antinuclear antibodies became positive. The diagnosis of subacute cutaneous lupus erythematosus is based on the clinical aspect of lesions, topography, histological finding, evolution and immunological profile of the patient.
authors.affiliation: Service de dermatologie, EPS Hédi-Chaker de Sfax, Tunisie. madiha.mseddi@laposte.net
authors.forename: M
authors.initials: M
authors.lastname: Mseddi
authors.forename: A
authors.initials: A
authors.lastname: Dammak
authors.forename: S
authors.initials: S
authors.lastname: Marrekchi
authors.forename: S
authors.initials: S
authors.lastname: Bouassida
authors.forename: A
authors.initials: A
authors.lastname: Zahaf
authors.forename: H
authors.initials: H
authors.lastname: Turki
mesh_terms: D000962:Antimalarials / Q000627:therapeutic use*; D002648:Child; D004890:Erythema / Q000188:drug therapy / Q000473:pathology; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000188:drug therapy / Q000473:pathology*; D012008:Recurrence; D012871:Skin Diseases / Q000188:drug therapy / Q000473:pathology*; D016896:Treatment Outcome
chemical_list: D000962:Antimalarials