Acute leukaemoid reaction following cardiac surgery.
Chronic myelomonocytic leukaemia is an atypical myeloproliferative disorder with a natural history of progression to acute myeloid leukaemia, a complex and poorly understood response by the bone marrow to stress. Cardiac surgery activates many inflammatory cascades and may precipitate a systemic inflammatory response syndrome. We present a case of undiagnosed chronic myelomonocytic leukaemia who developed rapidly fatal multi-organ dysfunction following cardiac surgery due to an acute leukaemoid reaction.
Drury
Nigel E
NE
Department of Cardiac Surgery, Papworth Hospital, Cambridge, CB23 3RE, UK. nigeldrury@gmail.com
Ali
Ayyaz
A
Mussa
Shafi
S
Webb
Stephen T
ST
Rege
Kanchan P
KP
Wallwork
John
J
D000368:Aged; D003324:Coronary Artery Disease / Q000601:surgery; D017809:Fatal Outcome; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000150:complications* / Q000175:diagnosis* / Q000628:therapy; D007955:Leukemoid Reaction / Q000209:etiology*; D008297:Male; D009204:Myocardial Revascularization / Q000009:adverse effects*