Multiple juvenile xanthogranulomas successfully treated with CO laser.
Juvenile xanthogranulomas are a rare disease entity within the spectrum of cutaneous non-Langerhans cell histiocytoses characterized by single or multiple cutaneous xanthogranulomas without further organ involvement. A 16-year-old girl developed multiple xanthogranulomas in various skin regions, especially the trunk and the flexural areas, over a period of 6 months. The clinical diagnosis was confirmed by H&E histology, showing a histiocytic infiltrate admixed with foam cells and Touton giant cells, and by immunohistochemistry using anti-bodies to stabilin-1 whose expression is highly specific for cutaneous non-Langerhans cell histiocytoses. No diabetes insipidus, pituitary hyperplasia or paraproteinemia were observed. Skin lesions were treated with a CO(2) laser and did not reappear during a 5 years follow-up period.
Klemke
Claus-Detlev
CD
Department of Dermatology,Venereology,and Allergology,University Medical Center Mannheim, Ruprecht Karls University of Heidelberg, Mannheim, Germany. Claus-Detlev.Klemke@haut.ma.uni-heidelberg.de
Held
Bjsrn
B
Dippel
Edgar
E
Goerdt
Sergij
S
D000293:Adolescent; D005260:Female; D006801:Humans; D053685:Laser Therapy / Q000379:methods*; D016896:Treatment Outcome; D014972:Xanthogranuloma, Juvenile / Q000473:pathology* / Q000601:surgery*