Controlling influenza virus replication by inhibiting its proton channel.
Influenza A and viruses encode minimalistic proton-selective ion channels known as A/M2 and BM2, respectively. The A/M2 channel is the target of the antiviral drug, amantadine. The structural and mechanistic aspects of proton conductance of the viral ion channels are described and the review makes a case for the development of more effective antivirals.
Pinto
Lawrence H
LH
Department of Neurobiology and Physiology, Hogan Hall, 2205 Tech Drive, Northwestern University, Evanston, IL 60208-3500, USA. larry-pinto@northwestern.edu
Lamb
Robert A
RA
D000547:Amantadine / Q000494:pharmacology; D000595:Amino Acid Sequence; D000998:Antiviral Agents / Q000494:pharmacology; D002462:Cell Membrane / Q000378:metabolism; D003593:Cytoplasm / Q000378:metabolism; D006801:Humans; D007473:Ion Channels / Q000737:chemistry / Q000378:metabolism* / Q000502:physiology; D017136:Ion Transport; D008954:Models, Biological; D008969:Molecular Sequence Data; D009975:Orthomyxoviridae / Q000502:physiology*; D011522:Protons; D014763:Viral Matrix Proteins / Q000737:chemistry / Q000378:metabolism*; D014779:Virus Replication; D000086082:Viroporin Proteins
D000547:Amantadine; D000998:Antiviral Agents; D007473:Ion Channels; D011522:Protons; D014763:Viral Matrix Proteins; C488937:M2 protein, Influenza A virus; D000086082:Viroporin Proteins