A conformational switch to beta-sheet structure in cytochrome c leads to heme exposure. Implications for cardiolipin peroxidation and apoptosis.
Balakrishnan
Gurusamy
G
Department of Chemistry, Princeton University, Princeton, New Jersey 08544, USA.
Hu
Ying
Y
Oyerinde
Oyeyemi F
OF
Su
Jia
J
Groves
John T
JT
Spiro
Thomas G
TG
D017209:Apoptosis; D002308:Cardiolipins / Q000737:chemistry* / Q000378:metabolism; D045304:Cytochromes c / Q000737:chemistry* / Q000378:metabolism; D006418:Heme / Q000737:chemistry* / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D007501:Iron / Q000737:chemistry / Q000378:metabolism; D008958:Models, Molecular; D010544:Peroxidases / Q000378:metabolism; D010545:Peroxides / Q000737:chemistry* / Q000378:metabolism; D017433:Protein Structure, Secondary; D013059:Spectrum Analysis, Raman; D013696:Temperature
D002308:Cardiolipins; D010545:Peroxides; D006418:Heme; D045304:Cytochromes c; D007501:Iron; D010544:Peroxidases