Global systems biology and personalized healthcare solutions.
Most drugs don't work optimally in most patients. The same drug can exert a significant overall therapeutic benefit in some patients while post a pronounced overall toxicity risk in others with the same disease. Pharmacogenomics has progressively received attention in the drug development process. But genetics is not the only factor that contributes to the differences that individual patients respond to drugs. Enter global systems biology.
Nicholson
Jeremy K
JK
Biological Chemistry, Biomedical Sciences Division, Imperial College London, Exhibition Road, South Kensington, London SW7 2AZ, UK.
Holmes
Elaine
E
D000818:Animals; D003695:Delivery of Health Care / Q000379:methods* / Q000639:trends; D006801:Humans; D010597:Pharmacogenetics; D057285:Precision Medicine; D051381:Rats; D049490:Systems Biology / Q000379:methods