title: Crystal structure of a complete ternary complex of TCR, superantigen and peptide-MHC.
abstract: 'Superantigens' (SAgs) trigger the massive activation of T cells by simultaneous interactions with MHC and TCR receptors, leading to human diseases. Here we present the first crystal structure, at 2.5-A resolution, of a complete ternary complex between a SAg and its two receptors, HLA-DR1/HA and TCR. The most striking finding is that the SAg Mycoplasma arthritidis mitogen, unlike others, has direct contacts not only with TCR Vbeta but with TCR Valpha.
authors.affiliation: Wadsworth Center, New York State Department of Health, Albany, New York 12201, USA.
authors.forename: Limin
authors.initials: L
authors.lastname: Wang
authors.forename: Yiwei
authors.initials: Y
authors.lastname: Zhao
authors.forename: Zhong
authors.initials: Z
authors.lastname: Li
authors.forename: Yi
authors.initials: Y
authors.lastname: Guo
authors.forename: Lindsay L
authors.initials: LL
authors.lastname: Jones
authors.forename: David M
authors.initials: DM
authors.lastname: Kranz
authors.forename: Walid
authors.initials: W
authors.lastname: Mourad
authors.forename: Hongmin
authors.initials: H
authors.lastname: Li
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000942:Antigens, Bacterial; D018360:Crystallography, X-Ray; D015798:HLA-DR1 Antigen / Q000737:chemistry*; D006388:Hemagglutinins / Q000737:chemistry*; D006801:Humans; D051379:Mice; D008934:Mitogens / Q000737:chemistry*; D008958:Models, Molecular; D008969:Molecular Sequence Data; D045645:Mycoplasma arthritidis / Q000276:immunology; D010455:Peptides / Q000737:chemistry; D011506:Proteins / Q000737:chemistry*; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000737:chemistry*; D018089:Superantigens / Q000737:chemistry*
chemical_list: D000942:Antigens, Bacterial; D015798:HLA-DR1 Antigen; D006388:Hemagglutinins; D008934:Mitogens; C052996:Mycoplasma arthritidis mitogen; D010455:Peptides; D011506:Proteins; D016693:Receptors, Antigen, T-Cell, alpha-beta; D018089:Superantigens