title: Gastrointestinal medications.
abstract: Medications to address gastrointestinal disorders are among the most commonly dispensed somatic medications. The authors examine proton pump inhibitors, H(2) blockers, 5-HT(3) receptor-antagonists, and a few other drugs that are used to address this domain of medical concerns. The metabolic pathways, interactions with the P-glycoprotein transporter, and capabilities of inhibiting or inducing metabolic enzymes are elucidated for each drug. Specific drug-drug interactions with each agent are also detailed, including both psychotropic and non-psychotropic agents. Also, the article explores how different genotypic variants for specific cytochrome P450 enzymes have an impact on the effectiveness and likelihood of drug-drug interactions relating to specific gastro-intestinal medications.
authors.affiliation: Walter Reed Army Medical Center, Washington, DC, USA. ghwynn@gmail.com
authors.forename: Gary H
authors.initials: GH
authors.lastname: Wynn
authors.forename: Neil B
authors.initials: NB
authors.lastname: Sandson
authors.forename: Kelly L
authors.initials: KL
authors.lastname: Cozza
mesh_terms: D018528:ATP-Binding Cassette Transporters / Q000187:drug effects; D003577:Cytochrome P-450 Enzyme System / Q000187:drug effects; D004347:Drug Interactions; D004790:Enzyme Induction / Q000187:drug effects; D005765:Gastrointestinal Agents / Q000009:adverse effects* / Q000493:pharmacokinetics / Q000627:therapeutic use; D006633:Histamine Antagonists; D006801:Humans; D054328:Proton Pump Inhibitors; D011619:Psychotropic Drugs / Q000009:adverse effects* / Q000493:pharmacokinetics / Q000627:therapeutic use; D011970:Receptors, Histamine H2 / Q000187:drug effects; D012307:Risk Factors; D058831:Serotonin 5-HT3 Receptor Antagonists
chemical_list: C107991:ABCB6 protein, human; D018528:ATP-Binding Cassette Transporters; D005765:Gastrointestinal Agents; D006633:Histamine Antagonists; D054328:Proton Pump Inhibitors; D011619:Psychotropic Drugs; D011970:Receptors, Histamine H2; D058831:Serotonin 5-HT3 Receptor Antagonists; D003577:Cytochrome P-450 Enzyme System