Understanding the biological significance of diphosphoinositol polyphosphates ('inositol pyrophosphates').
Among the many derivatives of the inositol-based signalling family are a subgroup that possess diphosphates. In this review, some recent research into the actions of these specialized polyphosphates is analysed, and key goals for future studies are identified, which, it is hoped, will result in the wider cell-signalling community giving considerably greater attention to this intriguing but relatively neglected class of inositol polyphosphates.
Shears
Stephen B
SB
Inositide Signaling Group, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, PO Box 12233, NC 27709, USA. shears@niehs.nih.gov
D000818:Animals; D011756:Diphosphates / Q000737:chemistry; D006801:Humans; D007294:Inositol / Q000737:chemistry / Q000502:physiology*; D007295:Inositol Phosphates / Q000737:chemistry / Q000502:physiology*; D015394:Molecular Structure; D011122:Polyphosphates / Q000737:chemistry
D011756:Diphosphates; D007295:Inositol Phosphates; D011122:Polyphosphates; D007294:Inositol