Changes in serum lipid profile and esterases of rats after sublethal daily doses of dimethoate.
Male Wistar rats were injected by dimethoate (10 mg/0.5 ml) daily for 8 successive days. Controls received the same amount of saline., A group of 5 rats were anesthetized at 0, 2, 4, 6 and 8 days of injection. Blood was withdrawn from heart. serum lipid components and 4 species of serum esterases were assayed for each group. A general decrease in the activities of serum esterases was observed. A marked decrease also was observed in lipids profile during the 8 days course of experiment.
Hassan
A A
AA
Applied Medical Chemistry Department, Medical Research Institute, Alexandria University, Egypt.
El-Khalili
M M
MM
Hussein
N G
NG
Kido
R
R
D000110:Acetylcholinesterase / Q000097:blood / Q000187:drug effects; D000818:Animals; D015415:Biomarkers / Q000097:blood; D001835:Body Weight / Q000187:drug effects; D002091:Butyrylcholinesterase / Q000097:blood / Q000187:drug effects; D002800:Cholinesterase Inhibitors / Q000633:toxicity*; D004117:Dimethoate / Q000633:toxicity*; D004353:Drug Evaluation, Preclinical; D002149:Energy Intake / Q000187:drug effects; D004781:Environmental Exposure / Q000009:adverse effects / Q000032:analysis; D004784:Environmental Monitoring / Q000379:methods; D004950:Esterases / Q000097:blood / Q000187:drug effects; D007274:Injections, Intraperitoneal; D007306:Insecticides / Q000633:toxicity*; D007928:Lethal Dose 50; D050356:Lipid Metabolism / Q000187:drug effects*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D015415:Biomarkers; D002800:Cholinesterase Inhibitors; D007306:Insecticides; D004950:Esterases; D000110:Acetylcholinesterase; D002091:Butyrylcholinesterase; D004117:Dimethoate