title: Alternative donor substrates for inverting and retaining glycosyltransferases.
abstract: By the use of glycosyl donors containing aromatic leaving groups linked with opposite anomeric configurations compared to those of the natural donor substrates, an inverting (Cst II) and a retaining (LgtC) glycosyltransferase were found to catalyse glycosylation reactions of natural acceptor substrates in the presence of the corresponding nucleotide.
authors.affiliation: Department of Chemistry, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z1.
authors.forename: Luke L
authors.initials: LL
authors.lastname: Lairson
authors.forename: Warren W
authors.initials: WW
authors.lastname: Wakarchuk
authors.forename: Stephen G
authors.initials: SG
authors.lastname: Withers
mesh_terms: D002236:Carbohydrate Conformation; D002384:Catalysis; D016695:Glycosyltransferases / Q000378:metabolism*; D013379:Substrate Specificity
chemical_list: D016695:Glycosyltransferases