title: Rapid lung volumetry using ultrafast dynamic magnetic resonance imaging during forced vital capacity maneuver: correlation with spirometry.
abstract: BACKGROUND
  Dynamic magnetic resonance imaging (MRI) has the potential for rapid noninvasive evaluation of changes in lung volume. The aim of this study was to perform rapid lung volumetry using ultrafast dynamic MRI to capture a forced vital capacity (FVC) maneuver.
  
  
  METHODS
  Nine healthy volunteers underwent 2-dimensional spoiled gradient echo imaging in coronal and sagittal planes during FVC maneuvers. An elliptical model of the axial cross section of the lungs was used to generate rapid volume-time curves. Spirometric indices were correlated with MR volumetry findings.
  
  
  RESULTS
  Total lung volume calculated from static MRI correlated well with the dynamic MR scans (r = 0.83; P < 0.01). Spirometric indices (first second of forced expiration and FVC) calculated from our MR volumetry technique correlated well with conventional spirometry (P < 0.01).
  
  
  CONCLUSIONS
  The technique provides a means of sampling lung volume change during the rapid subsecond movements that take place during a FVC maneuver.
authors.affiliation: Unit of Academic Radiology, University of Sheffield, Sheffield, United Kingdom. ajswifto@yahoo.com
authors.forename: Andy J
authors.initials: AJ
authors.lastname: Swift
authors.forename: Neil
authors.initials: N
authors.lastname: Woodhouse
authors.forename: Stan
authors.initials: S
authors.lastname: Fichele
authors.forename: Jochen
authors.initials: J
authors.lastname: Siedel
authors.forename: Gary H
authors.initials: GH
authors.lastname: Mills
authors.forename: Edwin J R
authors.initials: EJ
authors.lastname: van Beek
authors.forename: Jim M
authors.initials: JM
authors.lastname: Wild
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008168:Lung / Q000033:anatomy & histology*; D008176:Lung Volume Measurements; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D013147:Spirometry; D014797:Vital Capacity