title: BK virus infection in a renal transplant Saudi child.
abstract: BK human polyomavirus BKV causes an asymptomatic primary infection in children, but later, establishes latency mainly in the urinary tract. Virus-host interactions influencing persistence and pathogenicity are not well-understood. We present here a 12-year-old Saudi boy, who had renal transplant in Egypt. Seven months later, he was admitted to our Pediatric Nephrology Unit as a case of renal impairment. He developed BKV infection, diagnosed and successfully managed in our hospital. This case demonstrates the expanding clinical importance of BKV in a post renal transplant patient. This virus can be detected in transitional cells in the urine decoy cells using cytology. Testing for BKV deoxyribonucleic acid in urine and blood is an early detection assay, and can be used as a screening test in the early stages. The early reduction of immunosuppression can improve the prognosis. No specific antiviral treatment has been established yet. This is the first report of detecting BK virus in a Saudi post-transplant child in urine and blood specimens by using polymerase chain reaction.
authors.affiliation: Department of Pediatrics, King Khalid National Guard Hospital, Jeddah, Kingdom of Saudi Arabia.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Maghrabi
authors.forename: Dalia
authors.initials: D
authors.lastname: Marwan
authors.forename: Abimbola O
authors.initials: AO
authors.lastname: Osoba
mesh_terms: D001739:BK Virus; D002648:Child; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D027601:Polyomavirus Infections / Q000175:diagnosis*; D011183:Postoperative Complications / Q000175:diagnosis*; D012529:Saudi Arabia