Genetic tools to tailor cancer prevention by NSAIDs.
It was shown that NSAIDs, such as aspirin or Celebrex, are effective cancer preventive agents when taken regularly. However, the long-term use of NSAIDs, the cyclooxygenase (COX) inhibitors, may have significant adverse effects - primarily on the gastrointestinal (inhibiting COX-1) and cardiovascular (inhibiting COX-2) systems. Genetic analysis of enzymes (including COX) involved in the prostaglandin synthesis should reveal and predict a person's benefits vs. toxicity resulting from the NSAID treatment.
Ulrich
Cornelia M
CM
Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Bigler
Jeannette
J
Potter
John D
JD
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D001241:Aspirin / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use; D002319:Cardiovascular System / Q000187:drug effects* / Q000201:enzymology; D000068579:Celecoxib; D051545:Cyclooxygenase 1 / Q000378:metabolism; D051546:Cyclooxygenase 2 / Q000378:metabolism; D016861:Cyclooxygenase Inhibitors / Q000009:adverse effects / Q000627:therapeutic use; D041981:Gastrointestinal Tract / Q000187:drug effects* / Q000201:enzymology; D006801:Humans; D008954:Models, Biological; D009369:Neoplasms / Q000235:genetics / Q000517:prevention & control*; D011720:Pyrazoles / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use; D013449:Sulfonamides / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use
D000894:Anti-Inflammatory Agents, Non-Steroidal; D016861:Cyclooxygenase Inhibitors; D011720:Pyrazoles; D013449:Sulfonamides; D051545:Cyclooxygenase 1; D051546:Cyclooxygenase 2; D000068579:Celecoxib; D001241:Aspirin