Growth hormone-IGF-I axis and growth velocity in Chinese children with type 1 diabetes mellitus.
OBJECTIVE
To elucidate hormonal disturbances in patients with type 1 diabetes mellitus (DM1) with and without growth retardation.


METHODS
Patients with DM1 were divided into two groups, group A consisted of 14 patients with poor growth, and group B consisted of 24 patients with normal growth. Serum IGF-I, IGFBP-3, basal and stimulated GH, and HbA1c were measured.


RESULTS
Serum IGF-I and IGFBP-3 concentrations were significantly decreased in group A versus both groups B and controls in Tanner stages I-III; in addition, these measurements in group B were significantly lower compared to controls in Tanner stages II and III, but there was no significant difference in prepuberty. Both basal and peak serum GH were attenuated significantly in group A versus group B. Basal serum GH in group B (normal growth DM1) was significantly elevated versus the controls. There was an unambiguous negative linear regression between IGF-I and mean HbA1c in patients with DM1.


CONCLUSIONS
Growth retardation in patients with DM1 is associated with an abnormal GH-IGF-I axis and poor glycemic control.
Li
Guimei
G
Department of Pediatrics, Clinical Medical College of Shandong University, Shandong Provincial Hospital, China.
Mick
Gail
G
Wang
Xudong
X
Xue
Jiang
J
McCormick
Kenneth
K
D002648:Child; D003430:Cross-Sectional Studies; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000378:metabolism* / Q000503:physiopathology*; D005260:Female; D005947:Glucose / Q000378:metabolism; D006128:Growth / Q000502:physiology*; D006130:Growth Disorders / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology; D013006:Growth Hormone / Q000378:metabolism*; D006801:Humans; D007031:Hypothalamus / Q000503:physiopathology; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000378:metabolism; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D016014:Linear Models; D008297:Male; D010902:Pituitary Gland / Q000503:physiopathology
D018972:Insulin-Like Growth Factor Binding Protein 3; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone; D005947:Glucose