Pathophysiology of focal segmental glomerulosclerosis.
Focal segmental glomerulosclerosis (FSGS) is a major cause of idiopathic steroid-resistant nephrotic syndrome (SRNS) and end-stage kidney disease (ESKD). In recent years, animal models and studies of familial forms of nephrotic syndrome helped elucidate some mechanisms of podocyte injury and disease progression in FSGS. This article reviews some of the experimental and clinical data on the pathophysiology of FSGS.
Reidy
Kimberly
K
Division of Pediatric Nephrology, Children's Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, NY 10467, USA.
Kaskel
Frederick J
FJ
D000818:Animals; D005923:Glomerulosclerosis, Focal Segmental / Q000150:complications / Q000235:genetics / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D007678:Kidney Glomerulus / Q000473:pathology; D009404:Nephrotic Syndrome / Q000209:etiology; D050199:Podocytes / Q000473:pathology