title: Effects of the antioxidant succinobucol (AGI-1067) on human atherosclerosis in a randomized clinical trial.
abstract: BACKGROUND
  The antioxidant AGI-1067 was shown to reduce experimental atherosclerosis. The present study originally intended to study restenosis as a primary endpoint but was subsequently modified to primarily investigate the effects of AGI-1067 on coronary atherosclerosis.
  
  
  RESULTS
  This placebo-controlled randomized trial assessed the effects of AGI-1067 280 mg qd started before percutaneous coronary intervention (PCI) and administered for 12 months after PCI on atherosclerosis progression as assessed by coronary intravascular ultrasound (IVUS). Among patients with IVUS examinations considered technically adequate both at baseline and follow-up upon central laboratory assessments (n=232), plaque volume was not significantly modified with placebo (least squares mean change: -0.4mm(3), P=0.85 versus baseline), but was significantly reduced by -4.0mm(3) at end of treatment in the AGI-1067 group (P=0.001 versus baseline, P=0.12 versus placebo). LDL-cholesterol varied by -9% and +4% in the placebo and AGI-1067 groups, respectively (P<0.05 between groups), and HDL-cholesterol was reduced by 1% with placebo and 14% with AGI-1067 (P<0.05 between groups). Plasma myeloperoxidase was reduced by 6% with AGI-1067 (P<0.05) but hs-CRP was not significantly different between groups.
  
  
  CONCLUSIONS
  Atherosclerosis regression (-4.0mm(3)) was observed in patients treated with AGI-1067, although this was not significantly different from placebo. The anti-inflammatory effect of AGI-1067 is supported by reduced levels of myeloperoxidase.
authors.affiliation: Montreal Heart Institute and Université de Montréal, Montreal, Quebec, Canada. jean-claude.tardif@icm-mhi.org
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Tardif
authors.forename: Jean
authors.initials: J
authors.lastname: Grégoire
authors.forename: Philippe L
authors.initials: PL
authors.lastname: L'Allier
authors.forename: Reda
authors.initials: R
authors.lastname: Ibrahim
authors.forename: Todd J
authors.initials: TJ
authors.lastname: Anderson
authors.forename: François
authors.initials: F
authors.lastname: Reeves
authors.forename: Lawrence M
authors.initials: LM
authors.lastname: Title
authors.forename: Erick
authors.initials: E
authors.lastname: Schampaert
authors.forename: Michel
authors.initials: M
authors.lastname: LeMay
authors.forename: Jacques
authors.initials: J
authors.lastname: Lespérance
authors.forename: Rob
authors.initials: R
authors.lastname: Scott
authors.forename: Marie-Claude
authors.initials: MC
authors.lastname: Guertin
authors.forename: Marie-Luise
authors.initials: ML
authors.lastname: Brennan
authors.forename: Stanley L
authors.initials: SL
authors.lastname: Hazen
authors.forename: Olivier F
authors.initials: OF
authors.lastname: Bertrand
mesh_terms: D000368:Aged; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D000975:Antioxidants / Q000008:administration & dosage*; D015415:Biomarkers / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging / Q000188:drug therapy*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009195:Peroxidase / Q000097:blood; D011341:Probucol / Q000008:administration & dosage / Q000031:analogs & derivatives*; D016896:Treatment Outcome; D018084:Ultrasonography, Interventional
chemical_list: D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D015415:Biomarkers; D008078:Cholesterol, LDL; D009195:Peroxidase; C471047:succinobucol; D011341:Probucol