Hb Indianapolis [beta112 (G14) Cys-->Arg] as the probable cause of moderate hemolytic anemia and renal damage in a Brazilian patient.
Hemoglobin (Hb) Indianapolis [beta112 (G14) Cys-->Arg] is a rare and slightly unstable beta-globin variant. All carriers described to date were clinically normal with only mild reticulocytosis. We report here a case of a Brazilian patient in whom hemolytic anemia and acute renal failure were probably caused by the presence of this variant.
Fattori
A
A
Hematology and Hemotherapy Center, School of Medical Sciences, State University of Campinas-UNICAMP, Campinas, São Paulo, Brazil.
Kimura
E M
EM
Albuquerque
D M
DM
Oliveira
D M
DM
Costa
F F
FF
Sonati
M F
MF
D000328:Adult; D000743:Anemia, Hemolytic / Q000235:genetics / Q000378:metabolism* / Q000473:pathology*; D001120:Arginine / Q000235:genetics / Q000378:metabolism; D001483:Base Sequence; D001938:Brazil; D002648:Child; D002675:Child, Preschool; D003545:Cysteine / Q000235:genetics* / Q000378:metabolism; D005260:Female; D006455:Hemoglobins, Abnormal / Q000235:genetics* / Q000378:metabolism*; D006801:Humans; D007668:Kidney / Q000378:metabolism* / Q000473:pathology*; D008297:Male; D008969:Molecular Sequence Data
D006455:Hemoglobins, Abnormal; C032210:hemoglobin Indianapolis; D001120:Arginine; D003545:Cysteine