Schistosomiasis and malaria: another piece of the crossreactivity puzzle.
The recent discovery that individuals living in endemic areas have antibodies in their sera that are crossreactive for both helminth and malaria parasites raises important questions both of the interpretation of existing immunoepidemiological data and of the basic biology of the host and the parasites. One such shared antigen (SmLRR) has now been cloned and has, therefore, opened up an intriguing and exciting field of research for immunologists and parasitologists.
Helmby
Helena
H
Immunology Unit, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK. helena.helmby@lshtm.ac.uk
D000818:Animals; D000909:Antibodies, Helminth / Q000097:blood*; D000913:Antibodies, Protozoan / Q000097:blood*; D000947:Antigens, Helminth / Q000276:immunology*; D000953:Antigens, Protozoan / Q000276:immunology*; D003429:Cross Reactions; D006801:Humans; D008288:Malaria / Q000276:immunology*; D012552:Schistosomiasis / Q000276:immunology*
D000909:Antibodies, Helminth; D000913:Antibodies, Protozoan; D000947:Antigens, Helminth; D000953:Antigens, Protozoan