title: Transplantation's greatest challenges: advances in chronic graft-versus-host disease.
abstract: Clinical research into chronic graft-versus-host disease (GVHD) lags behind that in other areas in the field. Interest in chronic GVHD has increased significantly in recent years for various reasons, including advances in biotechnology, a perceived increase in the incidence of chronic GVHD, and decreased regimen-related mortality, resulting in a new emphasis on quality of life and absence of disability as endpoints of major significance in transplantation survivors. In this overview, we address 3 key areas related to chronic GVHD that hold the highest promise for major advances in the near future: pathobiology, response criteria, and therapy.
authors.affiliation: Department of Medical Oncology, Yale University School of Medicine, New Haven, Connecticut, USA.
authors.forename: Warren D
authors.initials: WD
authors.lastname: Shlomchik
authors.forename: Stephanie J
authors.initials: SJ
authors.lastname: Lee
authors.forename: Daniel
authors.initials: D
authors.lastname: Couriel
authors.forename: Steven Z
authors.initials: SZ
authors.lastname: Pavletic
mesh_terms: D002908:Chronic Disease; D006086:Graft vs Host Disease / Q000276:immunology / Q000628:therapy; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D016896:Treatment Outcome