title: Resistin gene polymorphisms and progression of glycaemia in southern Chinese: a 5-year prospective study.
abstract: OBJECTIVE
  Human resistin gene (RETN) polymorphisms have been found to be associated with type 2 diabetes (T2DM), insulin resistance and/or obesity. We evaluated, in a 5-year prospective study, whether RETN polymorphisms could predict the progression of glycaemia in southern Chinese.
  
  
  METHODS
  We conducted a systematic search for variants in RETN in 70 southern Chinese subjects. This was followed by the genotyping in 624 unrelated nondiabetic subjects of two polymorphisms, -420C-->G and +62G-->A, previously reported in cross-sectional studies to be associated with T2DM in Asians, to examine their relationship with the progression of glycaemia in this cohort.
  
  
  RESULTS
  We identified 15 polymorphisms, including 2 novel but rare polymorphisms (-319G-->A and +63G-->C). Compared to subjects with the CC genotype, -420GG subjects had higher 2-h glucose (7.7 +/- 1.8 vs. 7.2 +/- 2.0 mmol/l, P = 0.011) and insulin (101.6 +/- 69.5 vs. 79.8 +/- 59.5 mU/l, P = 0.021) during an oral glucose tolerance test. Carriers of the +62A allele had higher body mass indices (25.3 +/- 4.0 vs. 24.5 +/- 3.6 kg/m(2) in GG, P = 0.02). The presence of the allele -420G (OR 2.15, 95% CI 1.28-3.60, P = 0.004) or +62A (OR1.86, 95% CI 1.08-3.21, P = 0.025) predicted the progression of glycaemia at Year 5, after adjustment for sex, age or body mass index. The haplotype G-A also conferred a higher risk of progression in glycaemia (P = 0.002).
  
  
  CONCLUSIONS
  Our study would support the role of the resistin gene in obesity, insulin resistance and progression of glycaemia in southern Chinese.
authors.affiliation: Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, China.
authors.forename: Jian Yu
authors.initials: JY
authors.lastname: Xu
authors.forename: Pak C
authors.initials: PC
authors.lastname: Sham
authors.forename: Aimin
authors.initials: A
authors.lastname: Xu
authors.forename: Annette W K
authors.initials: AW
authors.lastname: Tso
authors.forename: Nelson M S
authors.initials: NM
authors.lastname: Wat
authors.forename: King Yip
authors.initials: KY
authors.lastname: Cheng
authors.forename: Carol H Y
authors.initials: CH
authors.lastname: Fong
authors.forename: Edward D
authors.initials: ED
authors.lastname: Janus
authors.forename: Karen S L
authors.initials: KS
authors.lastname: Lam
mesh_terms: D000328:Adult; D002681:China; D018450:Disease Progression; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D006943:Hyperglycemia / Q000235:genetics*; D007333:Insulin Resistance / Q000235:genetics; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D011446:Prospective Studies; D052243:Resistin / Q000235:genetics*
chemical_list: D052243:Resistin