title: [Prophylactic hepatic arterial infusion chemotherapy after curative surgery of colorectal liver metastases--the viewpoint from patients' quality of life].
abstract: In order to establish a reasonable prophylactic hepatic arterial infusion (HAI) chemotherapy following curative resection of colorectal liver metastases, the authors performed a randomized control study comparing two regimen. A weekly 5 hour-administration of 5-FU (1500 mg) which was repeated for 8 weeks showed a comparable effect to a continuous infusion group with an identical total dosage of 5-FU. Furthermore, adverse events were observed in only several patients of each group with low grade severity, suggesting that this simple regimen with a weekly HAI is promising. We also analyzed the clinical course of patients receiving HAI using a W spiral catheter which has a shape memory alloy in its tip. The catheter was implanted angiographycally without coil fixation to the vascular wall, which allowed us to remove the catheter after cessation of the scheduled chemotherapy. In all of the patients, the catheters were easily removed without any complications. A 3D-CT angiograph revealed that the hepatic arteries were well patent in all of the patients with a 3.3 Fr type catheter. HAI chemotherapy is basically an invasive treatment. In consideration of its efficacies as well as limitations, a reasonable approach is needed from the viewpoint of patients' quality of life.
authors.affiliation: Dept. of Surgery, NTT West Osaka Hospital.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Tono
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Kanoh
authors.forename: Tadashi
authors.initials: T
authors.lastname: Ohnishi
authors.forename: Ken
authors.initials: K
authors.lastname: Shiozaki
authors.forename: Masaki
authors.initials: M
authors.lastname: Matsushita
authors.forename: Hirotoshi
authors.initials: H
authors.lastname: Takemoto
authors.forename: Susumu
authors.initials: S
authors.lastname: Miyazaki
authors.forename: Hiromitsu
authors.initials: H
authors.lastname: Hoshino
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Kimura
authors.forename: Takashi
authors.initials: T
authors.lastname: Iwazawa
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Nakano
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yano
authors.forename: Takushi
authors.initials: T
authors.lastname: Monden
mesh_terms: D000792:Angiography; D002404:Catheterization; D015179:Colorectal Neoplasms / Q000473:pathology*; D005472:Fluorouracil / Q000008:administration & dosage* / Q000009:adverse effects; D006499:Hepatic Artery / Q000000981:diagnostic imaging; D006801:Humans; D007261:Infusions, Intra-Arterial; D008113:Liver Neoplasms / Q000517:prevention & control* / Q000556:secondary* / Q000601:surgery; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control; D011788:Quality of Life; D012189:Retrospective Studies
chemical_list: D005472:Fluorouracil