Elevated IgG titers to periodontal pathogens related to Buerger disease.
BACKGROUND
Periodontal pathogens were frequently detected in the occluded arteries of Buerger disease patients, hence we hypothesized that the infection from periodontal pathogens may be associated with Buerger disease.


METHODS
We investigated periodontal status using various clinical parameters and serum IgG antibody levels against T. denticola, P. gingivalis, A. actinomycetemcomitans and P. intermedia in nineteen Buerger disease patients and fifteen control subjects. The results were statistically analyzed.


RESULTS
The prevalence of periodontitis and the percentages of probing sites with PD> or =4 mm and CAL> or =4 mm were significantly higher in the patient group (P<0.001, P=0.016, and P<0.001, respectively). Patients had significantly higher serum IgG titers against T. denticola, P. gingivalis and A. actinomycetemcomitans (P=0.002, P=0.039, and P=0.011, respectively).


CONCLUSIONS
This study provides evidence for possible implications of periodontitis in Buerger disease.
Chen
Yi-Wen
YW
Iwai
Takehisa
T
Umeda
Makoto
M
Nagasawa
Toshiyuki
T
Huang
Yi
Y
Takeuchi
Yasuo
Y
Ishikawa
Isao
I
D016976:Aggregatibacter actinomycetemcomitans / Q000276:immunology; D016022:Case-Control Studies; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D010518:Periodontitis / Q000097:blood / Q000453:epidemiology / Q000382:microbiology*; D016966:Porphyromonas gingivalis / Q000276:immunology; D018713:Prevotella intermedia / Q000276:immunology; D013919:Thromboangiitis Obliterans / Q000097:blood* / Q000276:immunology / Q000382:microbiology; D048373:Treponema denticola / Q000276:immunology
D007074:Immunoglobulin G