title: Michael-type addition reactions for the in situ formation of poly(vinyl alcohol)-based hydrogels.
abstract: Michael-type addition reactions offer the possibility to obtain in situ formation of polymeric hydrogels in the absence of a radical mechanism for the networking process. We explored such a synthetic route for obtaining a poly(vinyl alcohol) (PVA)-based hydrogel as a potential biomaterial for applications in vitro-retinal replacement surgery. The presence of radicals in the reaction medium can represent a risk for in situ surgical treatment. To circumvent this problem we have applied nucleophilic addition to ad hoc modified PVA macromers. The gel formation has been studied with respect to the timing required in this surgery and in terms of the structural characteristics of the obtained network.
authors.affiliation: Dipartimento di Scienze e Tecnologie Chimiche, Università di Roma Tor Vergata, Via della Ricerca Scientifica, 00133 Roma, Italy.
authors.forename: Mariarosaria
authors.initials: M
authors.lastname: Tortora
authors.forename: Francesca
authors.initials: F
authors.lastname: Cavalieri
authors.forename: Ester
authors.initials: E
authors.lastname: Chiessi
authors.forename: Gaio
authors.initials: G
authors.lastname: Paradossi
mesh_terms: D000438:Alcohols / Q000737:chemistry; D001671:Biochemistry / Q000379:methods; D001672:Biocompatible Materials / Q000737:chemistry*; D005609:Free Radicals; D020100:Hydrogels / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D046911:Macromolecular Substances; D009682:Magnetic Resonance Spectroscopy; D008422:Materials Testing; D008956:Models, Chemical; D011108:Polymers / Q000737:chemistry; D011142:Polyvinyl Alcohol / Q000737:chemistry*; D013997:Time Factors
chemical_list: D000438:Alcohols; D001672:Biocompatible Materials; D005609:Free Radicals; D020100:Hydrogels; D046911:Macromolecular Substances; D011108:Polymers; D011142:Polyvinyl Alcohol