Neuroendocrine abnormalities in a neonate with congenital toxoplasmosis.
The central nervous system is often affected in patients with congenital toxoplasmosis. However, hypothalamo-pituitary dysfunction has rarely been reported in children with congenital toxoplasmosis, and no case with prolonged fever of central origin has been documented so far. We describe a newborn with congenital toxoplasmosis who presented with fever due to hypothalamo-pituitary dysregulation and combined hypothalamo-pituitary deficiencies consisting of central diabetes insipidus, hypothyroidism and ACTH deficiency.
Siahanidou
Tania
T
Neonatal Unit, First Department of Pediatrics, Athens University, "Aghia Sophia" Children's Hospital, Athens, Greece. neonat5@paidon-agiasofia.gr
Tsoumas
Dimitris
D
Kanaka-Gantenbein
Christina
C
Mandyla
Helen
H
D000324:Adrenocorticotropic Hormone / Q000172:deficiency; D003409:Congenital Hypothyroidism / Q000175:diagnosis / Q000209:etiology*; D020790:Diabetes Insipidus, Neurogenic / Q000175:diagnosis / Q000209:etiology*; D005334:Fever / Q000209:etiology; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology; D007231:Infant, Newborn; D008297:Male; D014125:Toxoplasmosis, Congenital / Q000150:complications* / Q000175:diagnosis
D000324:Adrenocorticotropic Hormone