In vitro activities of Citrus medica L. cv. Diamante (Diamante citron) relevant to treatment of diabetes and Alzheimer's disease.
The present study showed for the first time the in vitro properties (antioxidant, hypoglycaemic and anticholinesterase) of Citrus medica L. cv. Diamante which belongs to the Rutaceae family. The n-hexane extract of Diamante citron peel is characterized by the presence of monoterpenes and sesquiterpenes. The most abundant constituents were two monoterpenes: limonene and gamma-terpinene. The extract showed significant antioxidant activity that was carried out using different assays (DPPH test, beta-carotene bleaching test and bovine brain peroxidation assay). Oxidative damage, caused by the action of free radicals, may initiate and promote the progression of a number of chronic diseases, including diabetes and Alzheimer's disease. Diamante citron peel extract showed hypoglycaemic activity and an anticholinesterase effect.
Conforti
Filomena
F
Department of Pharmaceutical Sciences, University of Calabria, Rende (CS), Italy. filomena.conforti@unical.it
Statti
Giancarlo Antonio
GA
Tundis
Rosa
R
Loizzo
Monica Rosa
MR
Menichini
Francesco
F
D000544:Alzheimer Disease / Q000188:drug therapy; D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002417:Cattle; D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002957:Citrus / Q000737:chemistry*; D000081005:Cyclohexane Monoterpenes; D053138:Cyclohexenes / Q000737:chemistry / Q000302:isolation & purification; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000077222:Limonene; D015227:Lipid Peroxidation / Q000187:drug effects; D039821:Monoterpenes / Q000737:chemistry / Q000302:isolation & purification; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification
D000975:Antioxidants; D002800:Cholinesterase Inhibitors; D000081005:Cyclohexane Monoterpenes; D053138:Cyclohexenes; D007004:Hypoglycemic Agents; D039821:Monoterpenes; D010936:Plant Extracts; D013729:Terpenes; C018669:gamma-terpinene; D000077222:Limonene