title: Adenosine in burn blister fluid.
abstract: BACKGROUND
  Burn wound blister fluid is known to sustain suppressive effects on various components of the immune system. Damaged tissues cause an increase of adenosine concentrations. Since adenosine is a potent anti-inflammatory agent we hypothesized that burn blister fluid contains high concentrations of this nucleoside.
  
  
  METHODS
  Burn blister fluid was drawn from eleven patients who suffered a second degree burn injury. Adenosine concentrations were determined using high performance liquid chromatography (HPLC).
  
  
  RESULTS
  Elevated adenosine levels were detected in 6 of the 11 patients (54.5%), with an overall mean of 1.13+/-0.52 mM.
  
  
  CONCLUSIONS
  This is the first documented data showing increased concentrations of adenosine in burn blister fluid.
authors.affiliation: Department of General Surgery and Trauma Unit, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel. shakedg@bgu.ac.il
authors.forename: G
authors.initials: G
authors.lastname: Shaked
authors.forename: R
authors.initials: R
authors.lastname: Gurfinkel
authors.forename: D
authors.initials: D
authors.lastname: Czeiger
authors.forename: A
authors.initials: A
authors.lastname: Douvdevani
authors.forename: Y
authors.initials: Y
authors.lastname: Sufaro
mesh_terms: D000241:Adenosine / Q000378:metabolism*; D001768:Blister / Q000378:metabolism*; D002056:Burns / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D015536:Down-Regulation; D006706:Homeostasis; D006801:Humans; D013492:Suppuration / Q000378:metabolism; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism
chemical_list: D042461:Vascular Endothelial Growth Factor A; D000241:Adenosine