title: Bone cross-sectional geometry in adolescents and young women with anorexia nervosa: a hip structural analysis study.
abstract: BACKGROUND
  Better characterization of bone geometry in adolescents with anorexia nervosa (AN) may improve understanding of skeletal deficits in this population. Our objective was to determine whether hip cross-sectional geometry and bone strength were altered in adolescents with AN.
  
  
  METHODS
  Measurements of the left total proximal femur and body composition were obtained in 85 adolescents with AN and 61 healthy controls by dual X-ray absorptiometry. The Hip Structural Analysis (HSA) program was used to determine aBMD, cross-sectional area (CSA), and section modulus (Z) at the femoral neck and shaft. Strength indices were calculated and corrected for lean mass.
  
  
  RESULTS
  Femoral neck and shaft aBMD were lower in AN patients than healthy controls (-36% and -29%, p < 0.001). In both regions, bone CSA and Z were lower in AN sufferers (-11 to -35%, p < 0.001). While lean body mass correlated with HSA variables (r = 0.48 to 0.58, p < 0.001), body fat did not. AN sufferers had lower indices of both whole bone strength (-40%, p < 0.001) and relative bone strength (-36%, p < 0.001) than controls.
  
  
  CONCLUSIONS
  Anorexia nervosa sufferers had decreased resistance to axial (CSA) and bending loads (Z) compared with healthy controls. Differences in strength properties were significant even when adjusted for lean mass, suggesting that not only decreased mechanical loading, but also known metabolic differences are likely responsible for deficits in bone strength in these patients.
authors.affiliation: Division of Adolescent Medicine, Children's Hospital Boston, Boston, MA 02115, USA. amy.divasta@childrens.harvard.edu
authors.forename: A D
authors.initials: AD
authors.lastname: DiVasta
authors.forename: T J
authors.initials: TJ
authors.lastname: Beck
authors.forename: M A
authors.initials: MA
authors.lastname: Petit
authors.forename: H A
authors.initials: HA
authors.lastname: Feldman
authors.forename: M S
authors.initials: MS
authors.lastname: LeBoff
authors.forename: C M
authors.initials: CM
authors.lastname: Gordon
mesh_terms: D015502:Absorptiometry, Photon; D000293:Adolescent; D000328:Adult; D000856:Anorexia Nervosa / Q000473:pathology* / Q000503:physiopathology; D000886:Anthropometry / Q000379:methods; D001696:Biomechanical Phenomena; D001823:Body Composition; D015519:Bone Density; D005260:Female; D005269:Femur / Q000473:pathology* / Q000503:physiopathology; D005272:Femur Neck / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D016474:Weight-Bearing