title: Apolipoprotein E polymorphism, age and coronary heart disease.
abstract: Plasma concentrations of lipids, lipoproteins, and apolipoproteins (apo) are established risk factors for coronary heart disease (CHD). The knowledge of lipid profile may predict the potential victims of cardiovascular disease before its initiation and progression and offer the opportunity for primary prevention. The most common apo E polymorphism has been found to influence blood lipid concentrations and its correlation with CHD has been extensively investigated in the last decade. At younger ages, death from CHD is influenced by genetic factors, while the genetic effect decreases at older ages where environmental factors may play a more prominent role. If apo E polymorphism is an important genetic factor in the pathogenesis of atherosclerosis, it could affect the age of CHD onset. This review analyses the influence of apo E polymorphism on blood lipids and CHD in respect to age.
authors.affiliation: 1st Cardiology Department, Onassis Cardiac Surgery Center, 356 Sygrou Ave., 176 74 Athens, Greece. genovefa@kolovou.com
authors.forename: Genovefa D
authors.initials: GD
authors.lastname: Kolovou
authors.forename: Katherine K
authors.initials: KK
authors.lastname: Anagnostopoulou
mesh_terms: D000375:Aging / Q000235:genetics*; D001057:Apolipoproteins E / Q000235:genetics* / Q000502:physiology; D003324:Coronary Artery Disease / Q000235:genetics / Q000503:physiopathology; D003327:Coronary Disease / Q000235:genetics* / Q000503:physiopathology; D005838:Genotype; D006801:Humans; D050356:Lipid Metabolism / Q000235:genetics / Q000502:physiology; D008055:Lipids / Q000097:blood; D011110:Polymorphism, Genetic / Q000235:genetics; D012307:Risk Factors
chemical_list: D001057:Apolipoproteins E; D008055:Lipids