title: EPR study of copper(II) complexes of hydroxysalen derivatives in order to be used in the DNA cleavage.
abstract: Two series of functionalized hydroxy-salen-copper(II) complexes with various side chain lengths have been synthesized. The first one is characterised by amino side chain protected by the tert-butyloxycarbonyl group (Boc) whereas, the second series is obtained by removal of the Boc-protecting group under acidic conditions and formation instead of it an ammonium salt. EPR studies were carried out on the copper(II) complexes. EPR signals attributed to monomers and dimers of Cu2+ species were evidenced. Determination of the copper(II) environment in each complex was attempted using all the experimental results. Square planar and tetrahedral symmetries were found for the copper(II) monomers. From the fine structure observed for the pair signal, the distance between the Cu2+ ions in the pair has been calculated (3.9-4.3A). From these values, it seems that the formation of pairs is obtained by a face-to-face bimolecular association.
authors.affiliation: Laboratoire de Chimie Organique et Macromoléculaire, UMR CNRS 8009, USTL Bât., C3 - 59655 Villeneuve d'Ascq Cedex, France.
authors.forename: Géraldine
authors.initials: G
authors.lastname: Verquin
authors.forename: Gaëlle
authors.initials: G
authors.lastname: Fontaine
authors.forename: Edmond
authors.initials: E
authors.lastname: Abi-Aad
authors.forename: Elena
authors.initials: E
authors.lastname: Zhilinskaya
authors.forename: Antoine
authors.initials: A
authors.lastname: Aboukaïs
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Bernier
mesh_terms: D004247:DNA / Q000187:drug effects*; D004578:Electron Spin Resonance Spectroscopy; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D009942:Organometallic Compounds; D004247:DNA