title: Selective toxic effects of polyunsaturated fatty acids derived from Ulva fasciata on red tide phyotoplankter species.
abstract: Alpha-linolenic acid and linoleic acid isolated from Ulva fasciata showed toxic effects on red tide phytoplankters in a concentration-dependent manner. Among six species tested, raphidophycean flagellate Heterosigma akashiwo was the most susceptible to these fatty acids, and 50% lethal concentrations (LC50) of alpha-linolenic acid and linoleic acid were estimated to be 0.58 and 1.91 microg/ml respectively, whereas dinoflagellate Gymnodinium impudicum and Heterocapsa circularisquama were highly resistant and no significant toxic effects were observed up to 1,000 microg/ml. Both fatty acids were less toxic to fish (devil stinger), zooplankters (brine shrimp and rotifer), and mammalian cell lines (U937, HeLa, Vero, and CHO cells) than H. akashiwo.
authors.affiliation: Graduate School of Science and Technology, Nagasaki University, Japan.
authors.forename: Mochammad Amin
authors.initials: MA
authors.lastname: Alamsjah
authors.forename: Keiko
authors.initials: K
authors.lastname: Ishibe
authors.forename: Daekyung
authors.initials: D
authors.lastname: Kim
authors.forename: Kenichi
authors.initials: K
authors.lastname: Yamaguchi
authors.forename: Fumito
authors.initials: F
authors.lastname: Ishibashi
authors.forename: Yuji
authors.initials: Y
authors.lastname: Fujita
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Oda
mesh_terms: D000818:Animals; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D002522:Chlorocebus aethiops; D006224:Cricetinae; D004141:Dinoflagellida; D005231:Fatty Acids, Unsaturated / Q000737:chemistry* / Q000633:toxicity*; D006801:Humans; D010839:Phytoplankton / Q000737:chemistry*; D044445:Ulva / Q000737:chemistry*
chemical_list: D005231:Fatty Acids, Unsaturated