Synthesis, cytotoxicity and structure-activity relationship study of terpyridines.
For the development of novel antitumor agents, we designed and synthesized terpyridines, and their biological activities were evaluated. Although most of the newly prepared terpyridines showed strong cytotoxicity against several human cancer cell lines, [2,2';6',2"]-terpyridine displayed the most significant cytotoxicity.
Zhao
Long-Xuan
LX
College of Pharmacy, Yeungnam University, Kyongsan 712-749, Korea.
Sherchan
Jyoti
J
Park
Jung Ki
JK
Jahng
Yurngdong
Y
Jeong
Byeong-Seon
BS
Jeong
Tae Cheon
TC
Lee
Chong-Soon
CS
Lee
Eung-Seok
ES
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000633:toxicity*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D006801:Humans; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D011725:Pyridines / Q000138:chemical synthesis* / Q000633:toxicity*; D013329:Structure-Activity Relationship; D059004:Topoisomerase I Inhibitors
C517923:(2,2'-6',2'')-terpyridine; D000970:Antineoplastic Agents; D007202:Indicators and Reagents; D011725:Pyridines; D059004:Topoisomerase I Inhibitors