Synthesis of the isonicotinoylnicotinamide scaffolds of the naturally occurring isoniazid-NAD(P) adducts.
The first syntheses of the 1-hydroxy-1-(pyridin-4-yl)-1,2-dihydro-3H-pyrrolo[3,4-c]pyridin-3-one heterocycle and the 3-aminocarbonyl-4-isonicotinoyl-1,4-dihydropyridine framework present in the isoniazid-NAD(P) adducts are described.
Delaine
Tamara
T
Laboratoire de Chimie de Coordination du CNRS, 205 route de Narbonne, 31077 Toulouse cedex 4, France.
Bernardes-Génisson
Vania
V
Meunier
Bernard
B
Bernadou
Jean
J
D007538:Isoniazid / Q000737:chemistry*; D015394:Molecular Structure; D009249:NADP / Q000737:chemistry*
D009249:NADP; D007538:Isoniazid