Diastereocontrolled synthesis of enantioenriched 3,4-disubstituted beta-prolines.
Enantioenriched 3,4-disubstituted beta-prolines have been prepared with a high diastereocontrol through a carbometalation reaction or through a domino Michael addition/carbometalation reaction.
Denes
Fabrice
F
Laboratoire de Chimie Organique, UMR 7611, FR2769, Université Pierre et Marie Curie, Tour 44-45, 2ème étage, Case 183, 4 place Jussieu, 75252 Paris Cedex 05, France.
Perez-Luna
Alejandro
A
Chemla
Fabrice
F
D003500:Cyclization; D008968:Molecular Conformation; D011392:Proline / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D013237:Stereoisomerism
D011392:Proline; C072401:beta-proline