Methyl-CpG-binding domain proteins in plants: interpreters of DNA methylation.
The effect of DNA methylation on various aspects of plant cellular and developmental processes has been well documented over the past 35 years. However, the underlying molecular mechanism interpreting the methylation signal has only recently been explored with the isolation and characterization of the Arabidopsis methyl-CpG-binding domain (MBD) proteins. In this review, we highlight recent advances and present new models concerning Arabidopsis MBD proteins and their possible role in controlling chromatin structure mediated by CpG methylation.
Zemach
Assaf
A
Department of Plant Sciences, The Weizmann Institute of Science, Rehovot 76100, Israel.
Grafi
Gideon
G
D020816:Amino Acid Motifs; D017360:Arabidopsis / Q000235:genetics / Q000254:growth & development / Q000378:metabolism*; D029681:Arabidopsis Proteins / Q000737:chemistry / Q000502:physiology*; D001665:Binding Sites; D042002:Chromatin Assembly and Disassembly / Q000502:physiology; D017124:Conserved Sequence; D019175:DNA Methylation; D004268:DNA-Binding Proteins / Q000737:chemistry / Q000502:physiology*; D020868:Gene Silencing / Q000502:physiology; D020459:Genes, rRNA; D008957:Models, Genetic
D029681:Arabidopsis Proteins; D004268:DNA-Binding Proteins; C516650:MBD5 protein, Arabidopsis; C519565:MBD6 protein, Arabidopsis