Different isoforms of apolipoprotein AI present heterologous post-translational expression in HIV infected patients.
Human immunodeficiency virus (HIV) is rapidly becoming a global health concern. Proteomics technology was employed to examine HIV infected plasma samples in an attempt to identify disease-associated proteins. By comparison with normal and HIV positive plasma samples, at least eight proteins were significantly changed in HIV infected plasma. In particular, apolipoprotein AI presents a heterogeneous change in expression level with different isoforms. Apolipoprotein AI could be a useful biomarker for HIV diagnosis.
Kim
Sung-Soon
SS
Department of Virology, National Institute of Health, Seoul 122-701, Korea.
Kim
Mi-Hye
MH
Shin
Bo-Kyung
BK
Na
Han-Ju
HJ
Choi
Jin-Young
JY
Kee
Mee-Kyung
MK
Chong
Seon-Ah
SA
Nam
Myeong-Jin
MJ
D015492:AIDS Serodiagnosis / Q000379:methods*; D016632:Apolipoprotein A-I / Q000737:chemistry*; D015415:Biomarkers / Q000737:chemistry*; D016022:Case-Control Studies; D015180:Electrophoresis, Gel, Two-Dimensional / Q000379:methods; D015658:HIV Infections / Q000097:blood*; D006679:HIV Seropositivity / Q000097:blood*; D006801:Humans; D010949:Plasma / Q000378:metabolism; D020033:Protein Isoforms; D011499:Protein Processing, Post-Translational; D040901:Proteomics / Q000379:methods; D020133:Reverse Transcriptase Polymerase Chain Reaction; D019562:Viral Load
D016632:Apolipoprotein A-I; D015415:Biomarkers; D020033:Protein Isoforms