title: Pathophysiology of focal segmental glomerulosclerosis.
abstract: Focal segmental glomerulosclerosis (FSGS) is a major cause of idiopathic steroid-resistant nephrotic syndrome (SRNS) and end-stage kidney disease (ESKD). In recent years, animal models and studies of familial forms of nephrotic syndrome helped elucidate some mechanisms of podocyte injury and disease progression in FSGS. This article reviews some of the experimental and clinical data on the pathophysiology of FSGS.
authors.affiliation: Division of Pediatric Nephrology, Children's Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, NY 10467, USA.
authors.forename: Kimberly
authors.initials: K
authors.lastname: Reidy
authors.forename: Frederick J
authors.initials: FJ
authors.lastname: Kaskel
mesh_terms: D000818:Animals; D005923:Glomerulosclerosis, Focal Segmental / Q000150:complications / Q000235:genetics / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D007678:Kidney Glomerulus / Q000473:pathology; D009404:Nephrotic Syndrome / Q000209:etiology; D050199:Podocytes / Q000473:pathology