Leber hereditary optic neuropathy possibly triggered by exposure to tire fire.
We report three members of one family, a mother and two daughters aged 4 and 7 years, who developed visual loss from Leber hereditary optic neuropathy within a 19-month period. All three had been exposed to smoke from two large rubber tire fires within the previous 24 months, suggesting the possibility of an epigenetic triggering factor.
Sanchez
Ruben N
RN
Department of Ophthalmology, Doheny Eye Institute, University of Southern California, Keck School of Medicine, Los Angeles, California, USA.
Smith
Allison J
AJ
Carelli
Valerio
V
Sadun
Alfredo A
AA
Keltner
John L
JL
D000328:Adult; D000393:Air Pollutants / Q000009:adverse effects*; D002244:Carbon / Q000009:adverse effects; D002648:Child; D002675:Child, Preschool; D004252:DNA Mutational Analysis; D004272:DNA, Mitochondrial / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D008297:Male; D009154:Mutation / Q000235:genetics; D029242:Optic Atrophy, Hereditary, Leber / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D009900:Optic Nerve / Q000473:pathology / Q000503:physiopathology; D010375:Pedigree; D010578:Petroleum / Q000009:adverse effects; D012408:Rubber / Q000009:adverse effects
D000393:Air Pollutants; D004272:DNA, Mitochondrial; D010578:Petroleum; D002244:Carbon; D012408:Rubber