title: Metal-based turn-on fluorescent probes for sensing nitric oxide.
abstract: Nitric oxide, a reactive free radical, regulates a variety of biological processes. The absence of tools to detect NO directly, rapidly, specifically, and selectively motivated us to synthesize metal-based fluorescent probes to visualize the presence of NO. We prepared and investigated Co(II), Fe(II), Ru(II), Rh(II), and Cu(II) complexes as turn-on fluorescent NO sensors. Our exploration has provided insight into how the interaction of transition-metal centers with nitric oxide can be utilized for NO sensing.
authors.affiliation: Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
authors.forename: Mi Hee
authors.initials: MH
authors.lastname: Lim
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Lippard
mesh_terms: D005456:Fluorescent Dyes / Q000737:chemistry*; D008670:Metals / Q000737:chemistry*; D008958:Models, Molecular; D009569:Nitric Oxide / Q000032:analysis*
chemical_list: D005456:Fluorescent Dyes; D008670:Metals; D009569:Nitric Oxide