title: Pneumolysin, PspA, and PspC contribute to pneumococcal evasion of early innate immune responses during bacteremia in mice.
abstract: The pneumococcal virulence factors include capsule, PspA, PspC, and Ply. Cytometric analysis demonstrated that the greatest levels of C3 deposition were on a Deltaply PspA(-) PspC(-) mutant. Also, Ply, PspA, and PspC expression resulted in C3 degradation in vitro and in vivo. Finally, blood clearance assays demonstrated that there was enhanced clearance of Deltaply PspA(-) PspC(-) pneumococci compared to the clearance of nonencapsulated pneumococci.
authors.affiliation: Department of Microbiology, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA.
authors.forename: Lisa R
authors.initials: LR
authors.lastname: Quin
authors.forename: Quincy C
authors.initials: QC
authors.lastname: Moore
authors.forename: Larry S
authors.initials: LS
authors.lastname: McDaniel
mesh_terms: D000818:Animals; D000954:Antigens, Surface / Q000235:genetics / Q000502:physiology*; D016470:Bacteremia / Q000276:immunology; D001426:Bacterial Proteins / Q000235:genetics / Q000502:physiology*; D001769:Blood / Q000382:microbiology; D015169:Colony Count, Microbial; D003176:Complement C3 / Q000378:metabolism; D051379:Mice; D011008:Pneumococcal Infections / Q000276:immunology*; D013296:Streptococcus pneumoniae / Q000276:immunology* / Q000472:pathogenicity*; D013301:Streptolysins / Q000235:genetics / Q000502:physiology*; D037521:Virulence Factors / Q000235:genetics / Q000502:physiology*
chemical_list: D000954:Antigens, Surface; D001426:Bacterial Proteins; D003176:Complement C3; D013301:Streptolysins; D037521:Virulence Factors; C032290:plY protein, Streptococcus pneumoniae; C051592:pneumococcal surface protein A