title: Efficient synthesis of phenanthridinone derivatives via a palladium-catalyzed coupling process.
abstract: A palladium-mediated domino reaction was developed to conveniently synthesize phenanthridinone derivatives. Phosphine ligand 1 strongly promotes the domino process, which includes aryl-aryl coupling and C-N bond formations concomitant with a deamidation reaction. The versatility and applicability to a broad range of substrates make this reaction useful for the development of bioactive derivatives. [reaction: see text].
authors.affiliation: School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan. furuta@u-shizuoka-ken.ac.jp
authors.forename: Takumi
authors.initials: T
authors.lastname: Furuta
authors.forename: Yuki
authors.initials: Y
authors.lastname: Kitamura
authors.forename: Ayano
authors.initials: A
authors.lastname: Hashimoto
authors.forename: Satoshi
authors.initials: S
authors.lastname: Fujii
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Tanaka
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Kan
mesh_terms: D000085:Acetates / Q000737:chemistry; D002384:Catalysis; D008024:Ligands; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D010616:Phenanthrenes / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000085:Acetates; D008024:Ligands; D010616:Phenanthrenes; D010165:Palladium