[Change in the antigenic structure of surface glycoprotein E of tick-borne encephalitis virus during its adaptation to ticks and mammals].
Enzyme immunoassay and immunoprecipitation test of viral proteins, by applying a tick-borne encephalitis (TBE) viral protein E monoclonal antibody kit, have shown that TBE adaptation to ticks and mammals may cause a considerable change in the antigenic structure of surface glycoprotein E, by involving different antigenic domains, including a neutralizing epitope that seems to participate at the early stages of interaction of virions with the cell membrane.
Romanova
L Iu
LIu
Gmyl'
L V
LV
Loktev
V B
VB
Protopopova
E V
EV
Dzhivanian
T I
TI
Lashkevich
V A
VA
Karganova
G G
GG
D000222:Adaptation, Physiological; D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D000914:Antibodies, Viral / Q000276:immunology; D000956:Antigens, Viral / Q000276:immunology*; D004669:Encephalitis Viruses, Tick-Borne / Q000276:immunology / Q000502:physiology*; D000939:Epitopes / Q000276:immunology; D008322:Mammals; D009500:Neutralization Tests; D012692:Serial Passage; D013987:Ticks; D014759:Viral Envelope Proteins / Q000276:immunology*
D000911:Antibodies, Monoclonal; D000914:Antibodies, Viral; D000956:Antigens, Viral; D000939:Epitopes; D014759:Viral Envelope Proteins; C065696:glycoprotein E, Flavivirus