An experimentally antithrombotic strawberry variety is also effective in humans.
Prevention of arterial thrombotic diseases is of high priority in developed countries. As inappropriate diet is regarded as an important risk factor of thrombotic events, daily intake of an antithrombotic diet may offer a convenient and effective way of prevention. Earlier we used animal models of thrombosis to find fruits and vegetables with potential antithrombotic activity. Among various strawberry varieties tested, a particular variety (KYSt-4, Nohime) showed a significant antithrombotic effect. The aim of the present investigation was to extend this study to humans, by testing the experimentally active KYSt-4 and inactive KYSt-10 variety for effectiveness in humans after oral intake. Filtrates of strawberries were prepared and administered orally. Thrombotic status was tested by a novel global test (Gorog Thrombosis Test). The strawberry variety (KYSt-4; Nohime) which earlier inhibited experimental thrombosis showed antithrombotic effects in humans, while the experimentally inactive variety (KYSt-10) as well as the relevant control (water) were ineffective.
Naemura
Aki
A
Laboratory of Physiology, Faculty of Nutrition, Kobe Gakuin University, Nishi-ku, Kobe, Japan.
Ohira
Hideo
H
Ikeda
Masamichi
M
Koshikawa
Kaneyuki
K
Ishii
Hiromitsu
H
Yamamoto
Junichiro
J
D000293:Adolescent; D000328:Adult; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000494:pharmacology*; D001780:Blood Coagulation Tests; D004032:Diet; D005260:Female; D005343:Fibrinolytic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D031985:Fragaria / Q000737:chemistry*; D006801:Humans; D008163:Luminescent Measurements; D008297:Male; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats
D000975:Antioxidants; D005343:Fibrinolytic Agents; D010936:Plant Extracts