title: Endocrine disruption in nematodes: effects and mechanisms.
abstract: This paper reviews the current knowledge on endocrine disruption in nematodes. These organisms have received little attention in the field of ecotoxicology, in spite of their important role in aquatic ecosystems. Research on endocrine regulation and disruption in nematodes, especially the more recent studies, concentrate mainly on one species, Caenorhabditis elegans. Although an endocrine system is not known in nematodes, there is evidence that many processes are regulated via hormonal pathways. As vertebrate hormones, such as steroids, may have endocrine functions in nematodes as well, endocrine disrupting chemicals (EDCs) defined for vertebrates may also be able to influence nematodes. The studies that are reviewed here, and own data showed that potential EDCs can affect nematodes on all organizational levels, from molecules to communities. It is concluded that nematodes, notably its prominent species C. elegans, are a promising organism group for the development of biomonitoring tools, provided that more mechanistic evidence is gathered on hormonal processes within these animals.
authors.affiliation: Ecossa, Thierschstrasse 43, D-80538 Munich, Germany. hoess@ecossa.de
authors.forename: Sebastian
authors.initials: S
authors.lastname: Höss
authors.forename: Lennart
authors.initials: L
authors.lastname: Weltje
mesh_terms: D000818:Animals; D052244:Endocrine Disruptors / Q000633:toxicity*; D004784:Environmental Monitoring / Q000379:methods; D009348:Nematoda / Q000187:drug effects* / Q000502:physiology; D012098:Reproduction / Q000187:drug effects; D014874:Water Pollutants, Chemical / Q000633:toxicity; D015262:Xenobiotics / Q000633:toxicity
chemical_list: D052244:Endocrine Disruptors; D014874:Water Pollutants, Chemical; D015262:Xenobiotics