Drug eruption caused by ranitidine hydrochloride (Zantac) which showed a strong reaction in a drug-induced lymphocyte stimulation test.
An 80-year-old male who developed a generalized papular erythema-type drug eruption after being treated with ranitidine hydrochloride is herein reported. The duration from the intake of the medicine to the onset of the eruption was 3 days, and the eruption remained unchanged for a week after withdrawal of the medicine and even after the eruption itself was treated. A diagnosis of drug eruption by ranitidine hydrochloride was confirmed based on a strongly-positive reaction of a drug-induced lymphocyte stimulation test (DLST).
Okamoto
Osamu
O
Department of Anatomy, Biology and Medicine (Dermatology), Faculty of Medicine, Oita University, Hasama-machi, Yufu-shi, Oita, Japan. ookamoto@med.oita-u.ac.jp
Fujiwara
Sakuhei
S
D000369:Aged, 80 and over; D003875:Drug Eruptions / Q000209:etiology / Q000276:immunology / Q000473:pathology*; D006635:Histamine H2 Antagonists / Q000009:adverse effects*; D006801:Humans; D008213:Lymphocyte Activation; D008297:Male; D011899:Ranitidine / Q000009:adverse effects*
D006635:Histamine H2 Antagonists; D011899:Ranitidine