Cationic comb-type copolymers for boosting DNA-fueled nanomachines.
For the better applications and developments of DNA nanomachines, their responding kinetics, output, and sequence-selectivity need to be improved. Furthermore, the DNA nanomachines currently have several limitations in operating conditions. Here we show that a simple addition of a cationic comb-type copolymer, poly(l-lysine)-graft-dextran, produces the robust and quick responses of DNA nanomachines under moderate conditions including physiologically relevant conditions even at very low strand concentrations (nanomoles per liter range) through hybrid stabilization and DNA strand exchange acceleration.
Choi
Sung Won
SW
Institute for Materials Chemistry and Engineering, Kyushu University, 6-10-1 Hakozaki, Higashi, Fukuoka 812-8581, Japan.
Makita
Naoki
N
Inoue
Satoru
S
Lesoil
Charles
C
Yamayoshi
Asako
A
Kano
Arihiro
A
Akaike
Toshihiro
T
Maruyama
Atsushi
A
D001483:Base Sequence; D002412:Cations; D004247:DNA / Q000737:chemistry*; D003911:Dextrans / Q000737:chemistry*; D007700:Kinetics; D049329:Nanostructures; D011107:Polylysine / Q000737:chemistry*; D012965:Sodium Chloride / Q000737:chemistry
D002412:Cations; D003911:Dextrans; D011107:Polylysine; D012965:Sodium Chloride; D004247:DNA