title: Characterization and activity of sonochemically-prepared BSA microspheres containing Taxol--an anticancer drug.
abstract: Proteinaceous microspheres of BSA (Bovine Serum Albumin) containing an anticancer drug, Taxol (paclitaxel) were fabricated using a sonochemical procedure and then assayed for chemical and biological activity. The sonochemical reaction did not compromise the drug, which became encapsulated in the BSA microspheres. The amount of the anticancer drug in the microspheres was determined by HPLC. Anticancer activity of the proteinaceous microspheres encapsulating the Taxol was tested on Mouse Multiple Myeloma cell line MPC-11. The influence of the Taxol microspheres on the cancer cells was different from pristine Taxol. It was found that Taxol in combination with the organic solvent causes the death of cancer cells.
authors.affiliation: Department of Chemistry and Kanbar Laboratory for Nanomaterials at the Bar-Ilan University, Center for Advanced Materials and Nanotechnology, Bar-Ilan University, Ramat-Gan, 52900, Israel.
authors.forename: Olga
authors.initials: O
authors.lastname: Grinberg
authors.affiliation: The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 52900, Israel.
authors.forename: Michal
authors.initials: M
authors.lastname: Hayun
authors.affiliation: The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 52900, Israel.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Sredni
authors.affiliation: Department of Chemistry and Kanbar Laboratory for Nanomaterials at the Bar-Ilan University, Center for Advanced Materials and Nanotechnology, Bar-Ilan University, Ramat-Gan, 52900, Israel. Electronic address: gedanken@mail.biu.ac.il.
authors.forename: Aharon
authors.initials: A
authors.lastname: Gedanken
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D008863:Microspheres; D015394:Molecular Structure; D017239:Paclitaxel / Q000737:chemistry*; D012710:Serum Albumin, Bovine / Q000737:chemistry*; D013010:Sonication; D013499:Surface Properties; D013678:Technology, Pharmaceutical / Q000379:methods*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D012710:Serum Albumin, Bovine; D017239:Paclitaxel