title: Butyl 2-(4-[1.1'-biphenyl]-4-yl-1H-imidazol-2-yl)ethylcarbamate, a potent sodium channel blocker for the treatment of neuropathic pain.
abstract: A series of 4-arylimidazole carbamates was synthesized and their binding affinities to the site-2 sodium (Na+) channel were determined. SAR studies led to the identification of compound 10, a potent Na+ channel blocker which was efficacious in pain models in vivo.
authors.affiliation: Ipsen Research Laboratories, Institut Henri Beaufour, 5 avenue du Canada, 91966 Les Ulis Cedex, France. anne-marie.liberatore@ipsen.com
authors.forename: Anne-Marie
authors.initials: AM
authors.lastname: Liberatore
authors.forename: Jocelyne
authors.initials: J
authors.lastname: Schulz
authors.forename: Christine
authors.initials: C
authors.lastname: Favre-Guilmard
authors.forename: Jacques
authors.initials: J
authors.lastname: Pommier
authors.forename: Jacques
authors.initials: J
authors.lastname: Lannoy
authors.forename: Emilia
authors.initials: E
authors.lastname: Pawlowski
authors.forename: Marie-Anne
authors.initials: MA
authors.lastname: Barthelemy
authors.forename: Marion
authors.initials: M
authors.lastname: Huchet
authors.forename: Michel
authors.initials: M
authors.lastname: Auguet
authors.forename: Pierre-Etienne
authors.initials: PE
authors.lastname: Chabrier
authors.forename: Dennis
authors.initials: D
authors.lastname: Bigg
mesh_terms: D000818:Animals; D001496:Batrachotoxins; D001667:Binding, Competitive / Q000187:drug effects; D002219:Carbamates / Q000138:chemical synthesis* / Q000494:pharmacology*; D002351:Carrageenan; D006801:Humans; D006930:Hyperalgesia / Q000139:chemically induced / Q000188:drug therapy; D007093:Imidazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D007202:Indicators and Reagents; D008861:Microsomes / Q000187:drug effects / Q000378:metabolism; D010146:Pain / Q000188:drug therapy* / Q000209:etiology*; D010523:Peripheral Nervous System Diseases / Q000150:complications*; D051381:Rats; D012964:Sodium / Q000378:metabolism; D026941:Sodium Channel Blockers / Q000138:chemical synthesis* / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013574:Synaptosomes / Q000187:drug effects / Q000378:metabolism; D014701:Veratridine / Q000494:pharmacology
chemical_list: D001496:Batrachotoxins; D002219:Carbamates; D007093:Imidazoles; D007202:Indicators and Reagents; D026941:Sodium Channel Blockers; C519764:butyl 2-(4-(1.1'-biphenyl)-4-yl-1H-imidazol-2-yl)ethylcarbamate; D014701:Veratridine; D002351:Carrageenan; D012964:Sodium