title: trans-acetonide controlled endo-selective intramolecular nitrone-alkene cycloaddition of hept-6-enoses: a facile entry to calystegines, tropanes, and hydroxylated aminocycloheptanes.
abstract: High-yielding endo-selective intramolecular nitrone-alkene cycloaddition (INAC) reactions of hept-6-enoses controlled by a trans-acetonide to give bridged bicyclo[4.2.1]isoxazolidines exclusively are realized for the first time. The cycloadducts were readily transformed into calystegine, tropane, and hydroxylated aminocycloheptane frameworks. [reaction: see text].
authors.affiliation: Department of Chemistry and Center of Novel Functional Molecules, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China. tonyshing@cuhk.edu.hk
authors.forename: Tony K M
authors.initials: TK
authors.lastname: Shing
authors.forename: Wai F
authors.initials: WF
authors.lastname: Wong
authors.forename: Taketo
authors.initials: T
authors.lastname: Ikeno
authors.forename: Tohru
authors.initials: T
authors.lastname: Yamada