title: Effect of flavors on the viscosity and gelling point of aqueous poloxamer solution.
abstract: This study examined the effects of flavors, which are usually added to improve the appeal of pharmaceutical agents, on the viscosity and gelling point of 18% (w/w) aqueous poloxamer 407 solutions. Monoterpenes, esters, alcohols, aldehyde . ketones and lactone type flavors were examined. The concentrations of flavor ranged from 0.1 to 1.0% (w/w). After adding a flavor to the aqueous poloxamer 407 solution, the viscosity of the solution was measured using a Brookfield viscometer, and the gelling point was determined from the viscosity vs. temperature plot. The gelling point of the aqueous poloxamer 407 solution decreased with increasing concentration of flavors except for coumarin, vanillin and ethylvanillin. Thermal analysis with DSC showed an interaction between the flavors and poloxamer 407. These results suggest that the flavors bind to the hydrophilic end chains of poloxamer 407, which increases the viscosity, causing gelation at lower temperatures.
authors.affiliation: College of Pharmacy, Sungkyunkwan University, Suwon 440-746, Korea.
authors.forename: Yun-Seok
authors.initials: YS
authors.lastname: Rhee
authors.forename: Young-Hee
authors.initials: YH
authors.lastname: Shin
authors.forename: Chun-Woong
authors.initials: CW
authors.lastname: Park
authors.forename: Sang-Cheol
authors.initials: SC
authors.lastname: Chi
authors.forename: Eun-Seok
authors.initials: ES
authors.lastname: Park
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D002152:Calorimetry, Differential Scanning; D004952:Esters / Q000737:chemistry; D005421:Flavoring Agents / Q000737:chemistry*; D005782:Gels; D007659:Ketones / Q000737:chemistry; D019999:Pharmaceutical Solutions; D020442:Poloxamer / Q000737:chemistry*; D013501:Surface-Active Agents / Q000737:chemistry*; D014783:Viscosity
chemical_list: D000447:Aldehydes; D004952:Esters; D005421:Flavoring Agents; D005782:Gels; D007659:Ketones; D019999:Pharmaceutical Solutions; D013501:Surface-Active Agents; D020442:Poloxamer