title: PCDD/F and dioxin-like PCB in human blood and milk from German mothers.
abstract: Blood samples of pregnant women aged between 19 and 42 years at the time they gave birth and milk samples from the same women following delivery were collected between September 2000 and January 2003 from 169 participants living in an industrialized area of Germany (Duisburg birth cohort study). All samples were analyzed for their content of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/F) as well as dioxin-like and indicator polychlorinated biphenyls (PCB). Levels of WHO-TEq were in the range of 4.34-97.3 pg/g(lipid base) (median: 26.37, arithmetic mean: 28.36) for blood, or 3.01-78.7 pg/g(lipid base) (median: 26.40, arithmetic mean: 27.27) for milk, respectively. The four congeners 12378-PeCDD, 23478-PeCDF, 33'44'5-PeCB (# 126) and 233'44'5-HxCB (# 156) contribute the main share to total WHO-TEq. The contribution of PCDD/F in relation to PCB to total WHO-TEq was 60:40% in blood and 52:48% in milk. Good correlations of the contaminant levels in lipid base between both matrices were found. The distribution between blood and milk depends on the molecular weight of the substances. Higher chlorinated PCDD/F- and PCB-congeners were found in 2-4-fold higher concentrations in blood in relation to milk and the concentrations of lower chlorinated PCB-congeners were up to 2-fold higher in milk in relation to blood. The body burden of PCDD/F and PCB increases with age and decreases over the total nursing period. Women who had lived outside highly industrialized countries showed lower concentrations of PCDD/F and PCB. In some cases, elevated levels of PCB were observed when the women had previously lived in Eastern Europe for a long time. In comparison with recent data, the decline in human PCDD/F and PCB levels observed during the nineties seems to have stopped. The individual exposures of the infants due to breastfeeding within the first 18 months were calculated to be from 4.4 to 318 ng WHO-TEq (median: 106, arithmetic mean: 118). The actual mean daily exposure of a breastfed infant can be estimated to 131 pg WHO-TEq/kg(body weight).
authors.affiliation: Ruhr-Universtität Bochum, Abteilung für Hygiene, Sozial- und Umweltmedizin, Universitätsstrasse 150, D-44801 Bochum, Germany. wittsiepe@hygiene.rub.de
authors.forename: Jürgen
authors.initials: J
authors.lastname: Wittsiepe
authors.forename: Peter
authors.initials: P
authors.lastname: Fürst
authors.forename: Petra
authors.initials: P
authors.lastname: Schrey
authors.forename: Friederike
authors.initials: F
authors.lastname: Lemm
authors.forename: Martin
authors.initials: M
authors.lastname: Kraft
authors.forename: Georg
authors.initials: G
authors.lastname: Eberwein
authors.forename: Gerhard
authors.initials: G
authors.lastname: Winneke
authors.forename: Michael
authors.initials: M
authors.lastname: Wilhelm
mesh_terms: D000328:Adult; D001572:Benzofurans / Q000032:analysis* / Q000378:metabolism / Q000633:toxicity; D001774:Blood Chemical Analysis; D001942:Breast Feeding; D004785:Environmental Pollutants / Q000032:analysis / Q000378:metabolism / Q000633:toxicity; D005260:Female; D005858:Germany; D006798:Housing; D006801:Humans; D007221:Industry; D007223:Infant; D008895:Milk, Human / Q000737:chemistry*; D008970:Molecular Weight; D009035:Mothers; D011078:Polychlorinated Biphenyls / Q000032:analysis* / Q000378:metabolism / Q000633:toxicity; D000072317:Polychlorinated Dibenzodioxins / Q000031:analogs & derivatives* / Q000032:analysis / Q000378:metabolism / Q000633:toxicity; D013997:Time Factors
chemical_list: D001572:Benzofurans; D004785:Environmental Pollutants; D000072317:Polychlorinated Dibenzodioxins; C023614:dibenzofuran; D011078:Polychlorinated Biphenyls