title: The 25-hydroxyvitamin D threshold for better health.
abstract: Available data supporting a target serum level of at least 75 nmol/l 25-hydroxyvitamin D (25-OHD) include studies on bone mineral density (bmd), fracture prevention, lower extremity function, and cancer prevention. Given the high cost and disability from falls, fractures, and cancer treatment a shared threshold for 25-OHD has significant public health implications, especially so, if a large part of the population is below this threshold. This article summarizes available evidence supporting the 75 nmol/l threshold, reviews adherence to Vitamin D treatment in fracture trials in regard to achieved anti-fracture efficacy, and finally discusses current recommendations for Vitamin D intake.
authors.affiliation: Department of Rheumatology and Institute of Physical Medicine, University Hospital Zurich, Gloriastrasse 25, 8091 Zurich, Switzerland. Heiki.Bischoff@usz.ch
authors.forename: Heike A
authors.initials: HA
authors.lastname: Bischoff-Ferrari
mesh_terms: D015519:Bone Density / Q000187:drug effects; D050723:Fractures, Bone; D006262:Health; D006801:Humans; D035002:Lower Extremity / Q000473:pathology; D009369:Neoplasms / Q000378:metabolism / Q000401:mortality; D012307:Risk Factors; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood / Q000494:pharmacology
chemical_list: D014807:Vitamin D; C104450:25-hydroxyvitamin D