Plasma levels of soluble vascular endothelial growth factor receptor-1 (sVEGFR-1) in familial Mediterranean fever.
OBJECTIVE
To assess the levels of soluble vascular endothelial growth factor receptor-1 (sVEGFR-1) in patients with familial Mediterranean fever (FMF).


METHODS
Plasma levels of sVEGFR-1 were investigated in 33 FMF patients in an attack-free period (mean age 30.8 years; males/females 10/23), in 15 patients with acute FMF attack (mean age 32.7 years; males/females 7/8), and 19 healthy controls (mean age 32 years; males/females 11/8). Levels of sVEGFR-1 were also compared among patients who were receiving colchicine and those who were not.


RESULTS
Plasma sVEGFR-1 levels were 3.49+/-1.10, 3.53+/-1.02, and 0.37+/-0.28 ng/ml for FMF patients in the attack-free period, FMF patients with acute attack, and healthy controls, respectively. Plasma sVEGFR-1 levels were significantly higher in FMF patients with and without acute attack compared to the control group (p<0.05). sVEGFR-1 levels were not statistically significant between patients with acute attack and attack-free FMF patients (p>0.05). The plasma levels of sVEGFR-1 were also comparable in colchicine treated and untreated patients.


CONCLUSIONS
Our data suggest that sVEGFR-1 may have a role in the ongoing inflammatory cascade in FMF.
Başar
Omer
O
Department of Gastroenterology, Türkiye Yüksek Ihtisas Hospital, Ankara, Turkey.
Oztürk
Mehmet Akif
MA
Köklü
Seyfettin
S
Ayaz
Selime
S
Yüksel
Osman
O
Kiraz
Sedat
S
Ertenli
Ihsan
I
Calgüneri
Meral
M
D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D003078:Colchicine / Q000627:therapeutic use; D010505:Familial Mediterranean Fever / Q000097:blood* / Q000188:drug therapy; D005260:Female; D006074:Gout Suppressants / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D040281:Vascular Endothelial Growth Factor Receptor-1 / Q000097:blood*
D015415:Biomarkers; D006074:Gout Suppressants; D040281:Vascular Endothelial Growth Factor Receptor-1; D003078:Colchicine