title: Late outcome of sirolimus-eluting stents: comparison of multidetector computed tomography with quantitative coronary angiography and intravascular ultrasound.
abstract: OBJECTIVE
  To assess the performance of multidetector computed tomography in determining late clinical outcomes of patients undergoing sirolimus-eluting stent implantation.
  
  
  METHODS
  Thirty patients, successfully submitted to sirolimus-eluting stent implantation for more than six months, were selected to participate in the study. All underwent invasive angiography and intravascular ultrasound following CT angiography using iodinated contrast medium at a dose of 1.5 ml/kg.
  
  
  RESULTS
  Mean proximal reference diameter was 3.01 +/- 0.31 mm by tomography and 3.14 +/- 0.31 mm by angiography (p = 0.04). When the left circumflex artery was excluded from the analysis, the difference between both examinations was no longer significant (tomography = 3.01 +/- 0.32 mm; angiography = 3.10 +/- 0.30 mm, p = 0.65). Mean distal reference diameter was 2.86 +/- 0.30 mm by tomography and 2.92 +/- 0.32 by angiography (p = 0.25). Mean in-stent minimal lumen diameter was 2.85 +/- 0.25 mm by tomography and 2.85 +/- 0.29 mm by angiography (p = 0.27). Mean minimal in-stent cross-sectional area was 7.19 +/- 1.47 mm(2) by tomography and 6.90 +/- 1.52 mm(2) by intravascular ultrasound (p = 0.36), but there was only a weak correlation between these measurements (r = 0.33).
  
  
  CONCLUSIONS
  Computed tomography allows the qualitative assessment of sirolimus-eluting stents, accurate estimate of proximal and distal reference diameters of the target vessel, and in-stent minimal lumen diameter. Its correlation with measurements performed using intravascular ultrasound, however, is less strong.
authors.affiliation: Instituto Dante Pazzanese de Cardiologia e Hospital do Coração (HCor), São Paulo, SP, Brazil. ibraimp@uol.com.br
authors.forename: Ibraim Masciarelli F
authors.initials: IM
authors.lastname: Pinto
authors.forename: Amanda G M R
authors.initials: AG
authors.lastname: Sousa
authors.forename: Walther
authors.initials: W
authors.lastname: Ishikama
authors.forename: Luiz Alberto
authors.initials: LA
authors.lastname: Mattos
authors.forename: Alexandre
authors.initials: A
authors.lastname: Abizaid
authors.forename: Fausto
authors.initials: F
authors.lastname: Feres
authors.forename: Luiz Fernando L
authors.initials: LF
authors.lastname: Tanajura
authors.forename: Luiz C B
authors.initials: LC
authors.lastname: Sousa
authors.forename: J Eduardo M R
authors.initials: JE
authors.lastname: Sousa
authors.forename: Adib
authors.initials: A
authors.lastname: Jatene
mesh_terms: D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging / Q000628:therapy*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D020123:Sirolimus / Q000008:administration & dosage*; D015607:Stents; D014057:Tomography, X-Ray Computed / Q000379:methods; D016896:Treatment Outcome; D018084:Ultrasonography, Interventional
chemical_list: D020123:Sirolimus