title: Physiological correlates of age-related decline in vibrotactile sensitivity.
abstract: The purpose of this study was to describe age-related changes in vibrotactile sensitivity in participants of the Baltimore Longitudinal Study of Aging and to identify factors that are associated with impairment in vibrotactile sensitivity independent of age. Participants (n=523, age: 26-95 years) underwent measurements of vibration perception threshold (VPT, 100Hz) under the 2nd metatarsal head, glucose tolerance, serum inflammatory markers, nerve conduction parameters, movement time and cognition. Univariate and multivariate regression analyses were performed to identify factors that predicted VPT independent of age. Structural equation modeling was used to describe relationships between these variables. VPT was progressively higher with older age. Adjusting for age and height, VPT was similar in men and women and the slope of age-related decline was similar in the two genders. Age, height, peroneal nerve conduction velocity and peroneal nerve amplitude were independent predictors of VPT. Structural equation model demonstrated a direct relationship between peripheral nerve function and VPT. Height and circulating inflammatory markers may influence age-related decline in vibrotactile sensitivity through their negative impacts on peripheral nerve function.
authors.affiliation: Longitudinal Study Section, Clinical Research Branch, National Institute on Aging, National Institute of Health, Harbor Hospital, 3001 S. Hanover Street, Baltimore, MD 21225, USA. deshpanden@mail.nih.gov
authors.forename: Nandini
authors.initials: N
authors.lastname: Deshpande
authors.forename: E Jeffery
authors.initials: EJ
authors.lastname: Metter
authors.forename: Shari
authors.initials: S
authors.lastname: Ling
authors.forename: Robin
authors.initials: R
authors.lastname: Conwit
authors.forename: Luigi
authors.initials: L
authors.lastname: Ferrucci
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D003198:Computer Simulation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D012680:Sensitivity and Specificity; D012684:Sensory Thresholds / Q000502:physiology*; D014110:Touch / Q000502:physiology*; D014732:Vibration