title: Laser surgery of T1a glottic carcinomas; significance of resection margins.
abstract: Since 1995 patients with T1a glottic carcinomas have been treated with laser surgery at the Department of Otorhinolaryngology, Rikshospitalet in Oslo. During this period we have in many cases noticed an inconsistency between the clinical outcome and the histopathological report describing that the resection margins were not free. We wanted to investigate this discrepancy, and the charts with the histopathological reports of 171 patients treated between 1995 and 2005 have been reviewed. Seventeen patients (10%) experienced a recurrence of the initial disease and were treated by repeated laser surgery, radiotherapy, or radiotherapy and laryngectomy. Two patients (1%) had died from the disease. In 36% of the cases (62 patients) the histopathological report indicated "not free" or "probably not free" resection margins. The discrepancy between the histopathological reports and the clinical outcome reflects the pathologist's difficulty in orienting and determining resection margins in laser-resected specimens. Because of the low number of recurrences or metastases, the verdict of a violated resection margin should probably not be crucial for further treatment. The surgeon's peroperative judgement may be trusted, however, with very close follow-up in order to detect early recurrences.
authors.affiliation: Department of Otorhinolaryngology, Rikshospitalet- Radiumhospitalet Medical Center, University of Oslo, 0027, Oslo, Norway. kjell.brondbo@rikshospitalet.no
authors.forename: K
authors.initials: K
authors.lastname: Brøndbo
authors.forename: K
authors.initials: K
authors.lastname: Fridrich
authors.forename: M
authors.initials: M
authors.lastname: Boysen
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma / Q000473:pathology / Q000601:surgery*; D005931:Glottis / Q000473:pathology / Q000601:surgery*; D006801:Humans; D007822:Laryngeal Neoplasms / Q000473:pathology / Q000601:surgery*; D053685:Laser Therapy / Q000379:methods*; D008875:Middle Aged; D015996:Survival Rate; D016896:Treatment Outcome