[Epigenetic changes and liver carcinogenesis].
The molecular mechanisms involved in liver carcinogenesis are poorly understood. Over the past decade, epigenetic changes (DNA methylation) have received increasing attention for their potential involvement in the development of hepatocarcinoma. The DNA methylation level is influenced by environmental factors (folate and methionine diet), as well as by genetic factors (methylenetetrahydrofolate reductase/MTHFR polymorphisms). These findings provide new insight into the understanding of liver carcinogenesis. Interventional studies are now required to determine the role of folate supplementation in the development of liver tumors in targeted patients.
Peyrin-Biroulet
Laurent
L
Service d'Hépato-Gastroentérologie et Laboratoire de Pathologie Cellulaire et Moléculaire en Nutrition-INSERM U724, CHU Nancy, Vandoeuvre-les-Nancy. peyrin-biroulet@netcourrier.com
Barraud
Hélène
H
Darfeuil
Fabien
F
Lefebvre
Mathieu
M
Bigard
Marc-André
MA
Gueant
Jean-Louis
JL
Bronowicki
Jean-Pierre
JP
D006528:Carcinoma, Hepatocellular / Q000235:genetics*; D019175:DNA Methylation; D044127:Epigenesis, Genetic; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics*; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics; D011110:Polymorphism, Genetic
D042965:Methylenetetrahydrofolate Reductase (NADPH2)