title: Treatment of female pattern hair loss with a combination of spironolactone and minoxidil.
abstract: A 53-year-old woman with clinical evidence of female pattern hair loss and histological evidence of androgenetic alopecia was initially treated with the oral antiandrogen spironolactone 200 mg daily. Serial scalp photography documented hair regrowth at 12 months; however, the hair regrowth plateaued, and at 24 months there had been no further improvement in hair density. Twice daily therapy with topical minoxidil 5% solution was then introduced and further regrowth documented, confirming the additive effect of combination therapy.
authors.affiliation: Department of Dermatology, St Vincent's Hospital, University of Melbourne, Melbourne, Victoria, Australia.
authors.forename: Carlijn
authors.initials: C
authors.lastname: Hoedemaker
authors.forename: Sylvia
authors.initials: S
authors.lastname: van Egmond
authors.forename: Rodney
authors.initials: R
authors.lastname: Sinclair
mesh_terms: D000279:Administration, Cutaneous; D000284:Administration, Oral; D000505:Alopecia / Q000175:diagnosis* / Q000188:drug therapy* / Q000473:pathology; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008875:Middle Aged; D000451:Mineralocorticoid Receptor Antagonists / Q000008:administration & dosage / Q000627:therapeutic use*; D008914:Minoxidil / Q000008:administration & dosage / Q000627:therapeutic use*; D013148:Spironolactone / Q000008:administration & dosage / Q000627:therapeutic use*; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D000451:Mineralocorticoid Receptor Antagonists; D014665:Vasodilator Agents; D013148:Spironolactone; D008914:Minoxidil