Crystal structure of a complete ternary complex of TCR, superantigen and peptide-MHC.
'Superantigens' (SAgs) trigger the massive activation of T cells by simultaneous interactions with MHC and TCR receptors, leading to human diseases. Here we present the first crystal structure, at 2.5-A resolution, of a complete ternary complex between a SAg and its two receptors, HLA-DR1/HA and TCR. The most striking finding is that the SAg Mycoplasma arthritidis mitogen, unlike others, has direct contacts not only with TCR Vbeta but with TCR Valpha.
Wang
Limin
L
Wadsworth Center, New York State Department of Health, Albany, New York 12201, USA.
Zhao
Yiwei
Y
Li
Zhong
Z
Guo
Yi
Y
Jones
Lindsay L
LL
Kranz
David M
DM
Mourad
Walid
W
Li
Hongmin
H
D000595:Amino Acid Sequence; D000818:Animals; D000942:Antigens, Bacterial; D018360:Crystallography, X-Ray; D015798:HLA-DR1 Antigen / Q000737:chemistry*; D006388:Hemagglutinins / Q000737:chemistry*; D006801:Humans; D051379:Mice; D008934:Mitogens / Q000737:chemistry*; D008958:Models, Molecular; D008969:Molecular Sequence Data; D045645:Mycoplasma arthritidis / Q000276:immunology; D010455:Peptides / Q000737:chemistry; D011506:Proteins / Q000737:chemistry*; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000737:chemistry*; D018089:Superantigens / Q000737:chemistry*
D000942:Antigens, Bacterial; D015798:HLA-DR1 Antigen; D006388:Hemagglutinins; D008934:Mitogens; C052996:Mycoplasma arthritidis mitogen; D010455:Peptides; D011506:Proteins; D016693:Receptors, Antigen, T-Cell, alpha-beta; D018089:Superantigens