title: Correlation between timing of ASV administration and complications in snake bites.
abstract: OBJECTIVE
  The present study was undertaken to study the relationship between the time of anti-snake venom (ASV) administration due to late arrival of patient at hospital and subsequent development of complications.
  
  
  METHODS
  All patients of snake bite that presented to our institution over a period of 1 1/2 years were included in the present study. A detailed clinical history, clinical examination and investigations were carried out. The patients were administered ASV within 10 minutes of presentation. The bite to needle time (time between the bite and start of ASV) was noted. The patients were then followed up to note any subsequent development of complications. The end-point of the study was normalization of haematological and neurological parameters.
  
  
  RESULTS
  Fifty patients became eligible for the study. Twenty patients (40%) had complications while remaining 30 patients (60%) were uncomplicated. An attempt was made to study relationship between bite to needle time and subsequent development of complications. It was found to be significant at 5% level of significance (p<0.05) by chi square test.
  
  
  CONCLUSIONS
  Incidence of complications was directly proportional to the duration of venom in the blood prior to neutralization by ASV due to late arrival of patient at hospital. The early institution of ASV is beneficial in preventing complications however severe is the systemic envenomation.
authors.affiliation: Department of Medicine, Goa Medical College, Bambolim, Goa.
authors.forename: K
authors.initials: K
authors.lastname: Narvencar
mesh_terms: D058186:Acute Kidney Injury / Q000453:epidemiology* / Q000209:etiology*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D000997:Antivenins / Q000008:administration & dosage*; D002648:Child; D003161:Compartment Syndromes / Q000453:epidemiology / Q000209:etiology; D004211:Disseminated Intravascular Coagulation / Q000453:epidemiology* / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012128:Respiratory Distress Syndrome / Q000453:epidemiology / Q000209:etiology; D012769:Shock / Q000453:epidemiology / Q000209:etiology; D012909:Snake Bites / Q000150:complications* / Q000628:therapy*; D012910:Snake Venoms; D012911:Snakes; D013997:Time Factors
chemical_list: D000997:Antivenins; D012910:Snake Venoms