title: Incorrect use of orlistat and sibutramine in clinical practice.
abstract: OBJECTIVE
  To investigate how the antiobesity drugs orlistat and sibutramin are prescribed in relation to the approved indications and the Swedish subsidiary rules.
  
  
  METHODS
  Anonymous survey to prescribers of a random sample of 2000 out of 20,000 prescription of orlistat and sibutramin.
  
  
  RESULTS
  The response rate was around 65%. About half of the patients were not treated in accordance with the approved indications and a fourth of the patients prescribed sibutramin had one or several contraindications to the drug. The subsidiary rules were not followed in the majority of cases.
  
  
  CONCLUSIONS
  Deviation from the approved indications and subsidiary criteria of orlistat and sibutramin is a question of waste of medical and economic resources. Prescribing of sibutramin to patients with contraindications is a serious health hazard.
authors.affiliation: Medical Products Agency, P.O. Box 26, 751 03 Uppsala, Sweden.
authors.forename: Anna
authors.initials: A
authors.lastname: Dahlin
authors.forename: Björn
authors.initials: B
authors.lastname: Beermann
mesh_terms: D019440:Anti-Obesity Agents / Q000627:therapeutic use*; D001067:Appetite Depressants / Q000627:therapeutic use*; D000075202:Contraindications; D003503:Cyclobutanes / Q000627:therapeutic use*; D019983:Guideline Adherence / Q000706:statistics & numerical data; D006801:Humans; D007783:Lactones / Q000627:therapeutic use*; D008508:Medication Errors / Q000706:statistics & numerical data; D009765:Obesity / Q000188:drug therapy*; D000077403:Orlistat; D010818:Practice Patterns, Physicians' / Q000592:standards / Q000706:statistics & numerical data; D012307:Risk Factors; D011795:Surveys and Questionnaires; D013548:Sweden; D015431:Weight Loss / Q000187:drug effects
chemical_list: D019440:Anti-Obesity Agents; D001067:Appetite Depressants; D003503:Cyclobutanes; D007783:Lactones; D000077403:Orlistat; C058254:sibutramine