The Thr715Pro polymorphism of the P-selectin gene is not associated with ischemic stroke risk.
OBJECTIVE
A Thr>Pro polymorphism at codon 715 in the coding region of the P-selectin gene has recently been described. Individuals carrying the Pro715 allele were reported to have a reduced risk of myocardial infarction. A possible association of this polymorphism with the risk of ischemic stroke is currently under discussion.


METHODS
We investigated the prevalence of the 715 Thr>Pro polymorphism in 450 patients aged younger than 60 years with ischemic stroke or transient ischemic attack and in 450 controls without vascular disease matched for age and gender. We also investigated possible interactions of the polymorphism with other vascular risk factors, stroke severity and stroke etiology.


RESULTS
The distribution of the two allelic variants of the 715Thr>Pro polymorphism did not differ significantly between patients and control subjects (78% versus 81% for Thr/Thr, 21% versus 18% for Thr/Pro and 1% versus 1% for Pro/Pro in patients and controls, respectively; adjusted odds ratio for carriers of the C allele: 1.0 [0.8 to 1.2; P=0.695]). We found no significant interaction of this polymorphism with vascular risk factors, stroke severity, or stroke etiology.


CONCLUSIONS
Our study supports results from previous investigation showing that the 715Thr>Pro polymorphism of the P-selectin gene was not associated with a risk or clinical characteristics of ischemic stroke.
Ferrari
Julia
J
Department of Neurology, Hospital Barmherzige Brueder, Vienna, Austria.
Rieger
Sandra
S
Endler
Georg
G
Greisenegger
Stefan
S
Funk
Marion
M
Scholze
Thomas
T
Lang
Wilfried
W
Lalouschek
Wolfgang
W
Mannhalter
Christine
C
D000483:Alleles; D002545:Brain Ischemia / Q000453:epidemiology / Q000235:genetics*; D015331:Cohort Studies; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D019007:P-Selectin / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D015995:Prevalence; D011392:Proline / Q000235:genetics; D012042:Registries; D012307:Risk Factors; D020521:Stroke / Q000453:epidemiology / Q000235:genetics*; D013912:Threonine / Q000235:genetics
D019007:P-Selectin; D013912:Threonine; D011392:Proline