title: Large outbreak of infection and colonization with gram-negative pathogens carrying the metallo- beta -lactamase gene blaIMP-4 at a 320-bed tertiary hospital in Australia.
abstract: A large outbreak of infection and colonization with multiple genera of gram-negative bacilli carrying the metallo- beta -lactamase gene bla(IMP-4) occurred in a 36-bed intensive care unit at a tertiary hospital in Australia. The organisms emerged rapidly, caused severe infections, and contributed to mortality. Controlling the spread of these organisms remains a challenge for all staff involved.
authors.affiliation: Infectious Diseases and Microbiology Department, The Alfred Hospital, Melbourne, Victoria, Australia.
authors.forename: Sophie
authors.initials: S
authors.lastname: Herbert
authors.forename: Dag S
authors.initials: DS
authors.lastname: Halvorsen
authors.forename: Tim
authors.initials: T
authors.lastname: Leong
authors.forename: Clare
authors.initials: C
authors.lastname: Franklin
authors.forename: Glenys
authors.initials: G
authors.lastname: Harrington
authors.forename: Denis
authors.initials: D
authors.lastname: Spelman
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001315:Australia / Q000453:epidemiology; D003428:Cross Infection / Q000453:epidemiology* / Q000382:microbiology; D004196:Disease Outbreaks; D005260:Female; D006090:Gram-Negative Bacteria / Q000187:drug effects / Q000201:enzymology* / Q000235:genetics / Q000254:growth & development*; D016905:Gram-Negative Bacterial Infections / Q000453:epidemiology* / Q000382:microbiology; D006801:Humans; D007362:Intensive Care Units; D008297:Male; D008875:Middle Aged; D011550:Pseudomonas aeruginosa / Q000187:drug effects / Q000201:enzymology / Q000302:isolation & purification; D012706:Serratia marcescens / Q000187:drug effects / Q000201:enzymology / Q000302:isolation & purification; D018440:beta-Lactam Resistance; D001618:beta-Lactamases / Q000235:genetics* / Q000378:metabolism
chemical_list: C425142:beta-lactamase IMP-4; D001618:beta-Lactamases