A comparison between functional and radical sinus surgery in an experimental model of maxillary sinusitis.
OBJECTIVE
To compare functional and radical surgery in a maxillary sinusitis' treatment during in vivo experiments in rabbits.


METHODS
An experimental chronic maxillary sinusitis was induced in 21 New Zealand white rabbits by inducing mucosal trauma combined with an injection of Streptococcus pneumoniae, and a maxillary sinus ostium occlusion during 28 days. Functional surgery (FS) by reopening the natural ostium and radical surgery (RS) by reopening the natural ostium were performed in association with removal of the sinus mucosa. They were macroscopically and histologically evaluated 15 days, 1 month and 2 months after the surgery.


RESULTS
FS had diminished chronic inflammatory criteria (lymphoid and plasma cells) faster that RS ([15 days (p = 0.016)]; [1 month (p = 0.03)]; [2 months (p = 0.03)]). Mucosa fibrosis was more important after RS ([15 days (p = 0.016)]; [1 month (p = 0.03)]; [2 months (p = 0.016)]).


CONCLUSIONS
FS accelerates healing with less fibrosis that RS in pathological mucosa altered by a chronic inflammation.
Guevara
Nicolas
N
Department of Otorhinolaryngology, CHU Pasteur, Nice, France. nicolas.guevara@wanadoo.fr
Hofman
Veronique
V
Hofman
Paul
P
Santini
José
J
Castillo
Laurent
L
D000818:Animals; D008443:Maxillary Sinus / Q000601:surgery; D015523:Maxillary Sinusitis / Q000382:microbiology / Q000473:pathology / Q000601:surgery*; D011817:Rabbits; D013290:Streptococcal Infections / Q000473:pathology / Q000601:surgery; D014945:Wound Healing