title: SiiE is secreted by the Salmonella enterica serovar Typhimurium pathogenicity island 4-encoded secretion system and contributes to intestinal colonization in cattle.
abstract: Here we report that Salmonella enterica serovar Typhimurium pathogenicity island 4 carries a type I secretion system (siiCDF) which secretes an approximately 600-kDa protein (encoded by siiE). SiiE is surface expressed, and its production is regulated by HilA. SiiE and SiiF influence colonization in cattle and the invasion of bovine enterocytes.
authors.affiliation: Division of Microbiology, Institute for Animal Health, Compton, Nr Newbury, Berkshire, RG20 7NN, United Kingdom. eirwen.morgan@bbsrc.ac.uk
authors.forename: Eirwen
authors.initials: E
authors.lastname: Morgan
authors.forename: Alison J
authors.initials: AJ
authors.lastname: Bowen
authors.forename: Sonya C
authors.initials: SC
authors.lastname: Carnell
authors.forename: Timothy S
authors.initials: TS
authors.lastname: Wallis
authors.forename: Mark P
authors.initials: MP
authors.lastname: Stevens
mesh_terms: D000818:Animals; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D002417:Cattle; D044404:Genomic Islands / Q000502:physiology*; D007413:Intestinal Mucosa / Q000382:microbiology*; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism; D012486:Salmonella typhimurium / Q000235:genetics / Q000472:pathogenicity*; D037521:Virulence Factors / Q000235:genetics* / Q000502:physiology
chemical_list: D001426:Bacterial Proteins; D008565:Membrane Proteins; D037521:Virulence Factors