title: Late-onset tacrolimus-associated cerebellar atrophia in a heart transplant recipient.
abstract: Tacrolimus is a macrolide immunosuppressant frequently used after solid-organ transplantation. Moderate and severe neurologic side effects have been reported in patients receiving tacrolimus. Cerebral neurotoxicity is a rare but fatal calcineurin inhibitor-related complication, especially in kidney and liver transplant recipients. Often a reduction or a change in immunosuppressive regimen is the only means of clinical management. Herein we report a case of a 31-year-old man who developed cerebellar atrophia while under immunosuppressive therapy 9 years after heart transplantation. His neurologic constitution ameliorated after an immunosuppressant switch from tacrolimus to sirolimus.
authors.affiliation: Department of Cardiac Surgery, Ludwig Maximilians University, Munich, Germany. ingo.kaczmarek@med.uni-muenchen.de
authors.forename: I
authors.initials: I
authors.lastname: Kaczmarek
authors.forename: D
authors.initials: D
authors.lastname: Schmauss
authors.forename: R
authors.initials: R
authors.lastname: Sodian
authors.forename: A
authors.initials: A
authors.lastname: Beiras-Fernandez
authors.forename: M
authors.initials: M
authors.lastname: Oberhoffer
authors.forename: S
authors.initials: S
authors.lastname: Daebritz
authors.forename: S O
authors.initials: SO
authors.lastname: Schoenberg
authors.forename: B
authors.initials: B
authors.lastname: Reichart
mesh_terms: D000328:Adult; D005500:Follow-Up Studies; D006084:Graft Rejection / Q000517:prevention & control*; D016027:Heart Transplantation; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D008279:Magnetic Resonance Imaging; D008297:Male; D002527:Myoclonic Cerebellar Dyssynergia / Q000139:chemically induced* / Q000175:diagnosis; D016559:Tacrolimus / Q000009:adverse effects* / Q000627:therapeutic use; D013997:Time Factors
chemical_list: D007166:Immunosuppressive Agents; D016559:Tacrolimus