Vaccination against prion diseases.
Prion diseases are a group of fatal neurodegenerative conditions that affect humans and a wide variety of animals. To date there is no therapeutic or prophylactic approach against prion diseases available. The causative infectious agent is the prion, also termed PrP(Sc), which is a pathological conformer of the cellular prion protein PrP(C). As passive immunization studies with PrP(C)-specific antibodies indicated that immunotherapeutic strategies can prevent prion replication, researchers are now aiming at the development of active prion vaccines.
Kalinke
Ulrich
U
Divisions of Immunology and Medical Biotechnology, Paul-Ehrlich-Institut, Paul-Ehrlich-Str. 51-59, 63225 Langen, Germany.
Bach
Patricia
P
König
Martin
M
Buchholz
Christian J
CJ
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology*; D006801:Humans; D017096:Prion Diseases / Q000276:immunology* / Q000378:metabolism / Q000517:prevention & control*; D011328:Prions / Q000276:immunology / Q000378:metabolism; D014611:Vaccination
D000911:Antibodies, Monoclonal; D011328:Prions