[Experimental evaluation of the effect of glycine and its phosphorylated derivative on ischemic brain injury].
The effect of glycine and its phosphorylated derivative (AKF 90-7) on the ischemic brain injury in experimental animals has been studied. The therapeutic injection of glycine and AKF 90-7 (50 100 mg/kg) increased the survival of laboratory animals under the conditions of ischemia caused by ligation of the carotid artery. In a dose of 50 mg/kg, AKF 90-7 was more effective than glycine in activating enzymes of the antioxidant system and preventing the formation of lipid peroxidation products.
Makarova
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Pogorelyĭ
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D000818:Animals; D002545:Brain Ischemia / Q000188:drug therapy*; D004789:Enzyme Activation; D005998:Glycine / Q000031:analogs & derivatives* / Q000494:pharmacology; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D018696:Neuroprotective Agents / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000378:metabolism
C517200:N-acetylaminoacetic acid 3-dimethoxyphosphoryl-2-hydroxy-1-propyl ester; D018696:Neuroprotective Agents; D013482:Superoxide Dismutase; D005998:Glycine