Effects of progesterone on experimental spinal cord injury.
Progesterone has been proposed to be protective to the central nervous system following injury. This study assessed progesterone supplementation in the setting of contusional spinal cord injury in male and female rats. Short-term (5 days of either 4 or 8 mg/kg progesterone) and long-term (14 days of either 8 or 16 mg/kg progesterone) therapy failed to show any significant alteration in locomotor functioning and injury morphometrics after 21 days. This study does not support progesterone as a potential therapeutic agent in spinal cord injury.
Fee
Dominic B
DB
Department of Neurology, University of Kentucky Chandler Medical Center, Lexington, KY 40536, USA. dbfee@email.uky.edu
Swartz
Karin R
KR
Joy
Kelly M
KM
Roberts
Kelly N
KN
Scheff
Nicole N
NN
Scheff
Stephen W
SW
D000704:Analysis of Variance; D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D011374:Progesterone / Q000627:therapeutic use*; D011372:Progestins / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley; D020127:Recovery of Function / Q000187:drug effects; D012737:Sex Factors; D013119:Spinal Cord Injuries / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D013997:Time Factors
D011372:Progestins; D011374:Progesterone