title: [Primary research on anti-tumor activity of panaxadiol fatty acid esters].
abstract: For making use of Ginseng resources and finding new anti-tumor drugs, the anti-tumor activity of three kinds of new panaxadiol fatty acid ester derivates: 3beta-acetoxy panaxadiol (I), 3beta-palmitic acid aceloxy panaxadiol (II), 3beta-octadecanoic acid aceloxy panaxadiol (Ill) and panaxaiol were compared through the method of cell stain and counting. Tumor cell was Vero cell line. Positive control was 5-FU. Blank was RPM11640 culture medium. Negative control was RPM11640 culture medium and the solvent for subjected drugs. The result showed that compound I had the strongest anti-tumor activity, second was panaxadiol, II and III had the same and the weakest antitumor activity. Furthermore, the anti-tumor activities of panaxadiol fatty acid ester derivates showed positive correlation with subjects' concentrations, but no relationship with molecular weight of fatty acid.
authors.affiliation: Academy of Chinese Traditional Medicine, Jilin Agricultural University, Changchun 130118, China. zchlhh@tom.com
authors.forename: Chun-Hong
authors.initials: CH
authors.lastname: Zhang
authors.forename: Lian-Xue
authors.initials: LX
authors.lastname: Zhang
authors.forename: Xiang-Gao
authors.initials: XG
authors.lastname: Li
authors.forename: Yu-Gang
authors.initials: YG
authors.lastname: Gao
authors.forename: Ya-Jing
authors.initials: YJ
authors.lastname: Liu
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D002452:Cell Count; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002522:Chlorocebus aethiops; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000494:pharmacology*; D004952:Esters / Q000008:administration & dosage / Q000494:pharmacology; D005227:Fatty Acids / Q000008:administration & dosage / Q000494:pharmacology; D036145:Ginsenosides / Q000008:administration & dosage / Q000494:pharmacology*; D005894:Panax / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry; D014315:Triterpenes / Q000008:administration & dosage / Q000494:pharmacology*; D014709:Vero Cells
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D004952:Esters; D005227:Fatty Acids; D036145:Ginsenosides; D014315:Triterpenes; C004564:panaxadiol