Fusion of H4/D10S170 to PDGFRbeta in a patient with chronic myelomonocytic leukemia and long-term responsiveness to imatinib.
Drechsler
Matthias
M
Hildebrandt
Barbara
B
Kündgen
Andrea
A
Germing
Ulrich
U
Royer-Pokora
Brigitte
B
D001549:Benzamides; D003598:Cytoskeletal Proteins / Q000235:genetics; D050939:Gene Fusion / Q000187:drug effects*; D006801:Humans; D000068877:Imatinib Mesylate; D015477:Leukemia, Myelomonocytic, Chronic / Q000188:drug therapy* / Q000235:genetics*; D050506:Mutant Chimeric Proteins / Q000032:analysis / Q000187:drug effects / Q000235:genetics*; D010879:Piperazines / Q000494:pharmacology* / Q000627:therapeutic use; D047428:Protein Kinase Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D011743:Pyrimidines / Q000494:pharmacology* / Q000627:therapeutic use; D020797:Receptor, Platelet-Derived Growth Factor beta / Q000235:genetics; D014178:Translocation, Genetic / Q000187:drug effects
D001549:Benzamides; C088832:CCDC6 protein, human; D003598:Cytoskeletal Proteins; D050506:Mutant Chimeric Proteins; D010879:Piperazines; D047428:Protein Kinase Inhibitors; D011743:Pyrimidines; D000068877:Imatinib Mesylate; D020797:Receptor, Platelet-Derived Growth Factor beta