title: Analysis of anti-protective antigen IgG subclass distribution in recipients of anthrax vaccine adsorbed (AVA) and patients with cutaneous and inhalation anthrax.
abstract: The anti-PA IgG1, IgG2, IgG3, and IgG4 subclass responses to clinical anthrax and to different numbers of anthrax vaccine adsorbed (AVA, BioThrax) injections were determined in a cross-sectional study of sera from 63 vaccinees and 13 clinical anthrax patients. The data show that both vaccination with three AVA injections and clinical anthrax elicit anti-PA IgG1, IgG2, and IgG3 subclass responses. An anti-PA IgG4 response was detected in AVA recipients after the fourth injection. The anthrax lethal toxin (LTx) neutralization efficacy of sera from recipients who received 4 to > or =10 AVA injections did not vary significantly in relation to changes in distribution of anti-PA IgG1 and IgG4 subclasses.
authors.affiliation: Centers for Disease Control and Prevention, Atlanta, GA 30333, USA. vsemenova@cdc.gov
authors.forename: V A
authors.initials: VA
authors.lastname: Semenova
authors.forename: D S
authors.initials: DS
authors.lastname: Schmidt
authors.forename: T H
authors.initials: TH
authors.lastname: Taylor
authors.forename: H
authors.initials: H
authors.lastname: Li
authors.forename: E
authors.initials: E
authors.lastname: Steward-Clark
authors.forename: S D
authors.initials: SD
authors.lastname: Soroka
authors.forename: M M
authors.initials: MM
authors.lastname: Ballard
authors.forename: C P
authors.initials: CP
authors.lastname: Quinn
mesh_terms: D000328:Adult; D000368:Aged; D000881:Anthrax / Q000276:immunology*; D022122:Anthrax Vaccines / Q000276:immunology*; D000907:Antibodies, Bacterial / Q000097:blood* / Q000145:classification*; D000942:Antigens, Bacterial / Q000276:immunology*; D000992:Antitoxins / Q000097:blood; D001427:Bacterial Toxins / Q000276:immunology*; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood* / Q000145:classification*; D008297:Male; D008875:Middle Aged
chemical_list: D022122:Anthrax Vaccines; D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D000992:Antitoxins; D001427:Bacterial Toxins; D007074:Immunoglobulin G; C030325:anthrax toxin