title: Analysis of intramolecular dynamic processes in enantiomeric diaryl atropisomers and related derivatives by 2H NMR spectroscopy in polypeptide liquid crystals.
abstract: We demonstrate the analytical potential of 2H-{1H} NMR spectroscopy in weakly ordering, chiral lyotropic liquid crystals made of poly(gamma-benzyl-L-glutamate) (PBLG) dissolved in chloroform or dichloromethane for investigating the intramolecular dynamic processes of four deuterated diaryls (derivatives of 1-(4'-methylphenyl)naphthalene). When the rotation of the aryl groups about the sp(2)--sp(2) bond is sufficiently slow relative to the NMR timescale, the method allows the spectral discrimination of enantiomeric atropisomers or enantiotopic directions in the prochiral derivatives. The effect of the position of substituents on the phenyl group on the conformational dynamics of these compounds has been examined as well as the nature of the organic co-solvent. When coalescence phenomena are observed, simulation of the experimental 2H-{1H} lineshapes using a formalism tailored for two deuterons undergoing mutual exchange allows the rate constants and the activation parameters for the internal rotation processes to be calculated. Experimental values of DeltaH(not equal) have been compared with data evaluated by molecular modelling calculations and the activation parameters are discussed for the various compounds. It is shown that these polypeptide mesophases have no significant impact on the interconversion dynamics of these compounds. In contrast with the nematic thermotropic phases, Haller's equation cannot be used to predict the evolution of the quadrupolar splittings (Deltanu(Q) values), and hence the order parameters, versus T in the PBLG mesophases. For these particular lyotropic systems, it is shown that an exponential function of the form Deltanu(Q)[Hz]=C x exp (-E/RT[K]) provides excellent agreement between the experimental and expected Deltanu(Q) values. Analysis of the results reported in this work suggests that orientation and chiral discrimination phenomena in these lyotropic solvents could be treated separately because they would involve different interaction mechanisms.
authors.affiliation: Laboratoire de Chimie Structurale Organique, ICMMO UMR CNRS 8182, Bât. 410, Université de Paris-Sud, 91405 Orsay, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Lafon
authors.forename: Philippe
authors.initials: P
authors.lastname: Lesot
authors.forename: Chun-An
authors.initials: CA
authors.lastname: Fan
authors.forename: Henri B
authors.initials: HB
authors.lastname: Kagan
mesh_terms: D007536:Isomerism; D050866:Liquid Crystals / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009281:Naphthalenes / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry*; D012997:Solvents / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D009281:Naphthalenes; D010455:Peptides; D012997:Solvents