title: The heritability of cluster A personality disorders assessed by both personal interview and questionnaire.
abstract: BACKGROUND
  Personality disorders (PDs) as assessed by questionnaires and personal interviews are heritable. However, we know neither how much unreliability of measurement impacts on heritability estimates nor whether the genetic and environmental risk factors assessed by these two methods are the same. We wish to know whether the same set of PD vulnerability factors are assessed by these two methods.
  
  
  METHODS
  A total of 3334 young adult twin pairs from the Norwegian Institute of Public Health Twin Panel (NIPHTP) completed a questionnaire containing 91 PD items. One to 6 years later, 1386 of these pairs were interviewed with the Structured Interview for DSM-IV Personality (SIDP-IV). Self-report items predicting interview results were selected by regression. Measurement models were fitted using Mx.
  
  
  RESULTS
  In the best-fit models, the latent liabilities to paranoid personality disorder (PPD), schizoid personality disorder (SPD) and schizotypal personality disorder (STPD) were all highly heritable with no evidence of shared environmental effects. For PPD and STPD, only unique environmental effects were specific to the interview measure whereas both environmental and genetic effects were found to be specific to the questionnaire assessment. For SPD, the best-fit model contained genetic and environmental effects specific to both forms of assessment.
  
  
  CONCLUSIONS
  The latent liabilities to the cluster A PDs are highly heritable but are assessed by current methods with only moderate reliability. The personal interviews assessed the genetic risk for the latent trait with excellent specificity for PPD and STPD and good specificity for SPD. However, for all three PDs, the questionnaires were less specific, also indexing an independent set of genetic risk factors.
authors.affiliation: Department of Psychiatry, Medical College of Virginia of Virginia Commonwealth University, Richmond, VA 23298-0126, USA. kendler@vcu.edu
authors.forename: Kenneth S
authors.initials: KS
authors.lastname: Kendler
authors.forename: John
authors.initials: J
authors.lastname: Myers
authors.forename: Svenn
authors.initials: S
authors.lastname: Torgersen
authors.forename: Michael C
authors.initials: MC
authors.lastname: Neale
authors.forename: Ted
authors.initials: T
authors.lastname: Reichborn-Kjennerud
mesh_terms: D000328:Adult; D016000:Cluster Analysis; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D006801:Humans; D007406:Interview, Psychological; D008297:Male; D010554:Personality Disorders / Q000145:classification / Q000175:diagnosis* / Q000235:genetics*; D011795:Surveys and Questionnaires; D014427:Twins / Q000235:genetics* / Q000523:psychology*; D014434:Type A Personality