title: Esophageal cancer in Central and Eastern Europe: tobacco and alcohol.
abstract: Esophageal cancer mortality rates in Central and Eastern Europe have been increasing steadily and are expected to increase further in the future. To evaluate the role of risk factors for esophageal cancer in this population, a multicenter study was conducted, with investigation of tobacco and alcohol as one of the principal aims. We have included 192 squamous cell carcinoma (SCC) and 35 adenocarcinoma cases of the esophagus diagnosed at designated hospitals in 5 centers from Romania, Russia, the Czech Republic and Poland. Controls were frequency matched from patients in the same hospital as the cases (n=1,114). Our results showed that the risk of esophageal SCC may be increased by approximately 7-fold for current smokers (OR=7.41, 95% CI 3.98-13.79) and by 3-fold for ever alcohol drinkers (OR=2.86, 95% CI 1.06-7.74). Dose-response relations were evident for both the frequency and duration of tobacco and of alcohol on the risk of esophageal SCC. Risk estimates for tobacco smoking were highest for lower esophageal SCCs, while risk estimates for alcohol drinking were highest for upper esophageal SCCs; though differences were not statistically significant. For adenocarcinoma of the esophagus, our results suggested a more modest increase in risk because of tobacco smoking than that for SCC of the esophagus and no association with alcohol consumption, although our sample size was small. A synergistic interaction between tobacco and alcohol was observed for the risk of esophageal SCC, highlighting the importance of both factors for esophageal cancers in Central and Eastern Europe.
authors.affiliation: International Agency for Research on Cancer, Lyon, France.
authors.forename: Mia
authors.initials: M
authors.lastname: Hashibe
authors.forename: Paolo
authors.initials: P
authors.lastname: Boffetta
authors.forename: Vladimir
authors.initials: V
authors.lastname: Janout
authors.forename: David
authors.initials: D
authors.lastname: Zaridze
authors.forename: Oxana
authors.initials: O
authors.lastname: Shangina
authors.forename: Dana
authors.initials: D
authors.lastname: Mates
authors.forename: Neonila
authors.initials: N
authors.lastname: Szeszenia-Dabrowska
authors.forename: Vladimir
authors.initials: V
authors.lastname: Bencko
authors.forename: Paul
authors.initials: P
authors.lastname: Brennan
mesh_terms: D000230:Adenocarcinoma / Q000453:epidemiology / Q000209:etiology*; D000328:Adult; D000368:Aged; D000428:Alcohol Drinking / Q000009:adverse effects*; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology / Q000209:etiology*; D016022:Case-Control Studies; D003043:Cocarcinogenesis; D004938:Esophageal Neoplasms / Q000453:epidemiology / Q000209:etiology*; D005061:Europe, Eastern / Q000453:epidemiology; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects*