title: Thinner abuse alters peak of frequency of EEG spectra analyses.
abstract: OBJECTIVE
  The aim of the investigation was to use electroencephalography (EEG) to study whether long-term thinner abuse may result in the slowing, disorganization and asymmetry of the EEG cortical rhythms.
  
  
  METHODS
  Twenty-two patients attending with antecedent of thinner abuse only, and twenty two controls without alcohol, smoking, and drug abuse in the same age range and gender were studied. EEG recording were compared by means of the analyses of peak of frequency (POF), frequency of disorganization, and asymmetry of the background activity in patients and controls at rest eyes-closed condition in electrodes P3, P4, O1, and O2.
  
  
  RESULTS
  Significant differences in POF among groups was observed in P3 and P4 location showing lower values in thinner abusers, but not in O1 and O2 locations. Frequencies of disorganization and asymmetry showed significantly higher proportions in thinner abusers. Bivariate correlations among POF at the four electrode location and time of thinner abuse showed significant values. However after partial correlation calculation correcting for age, significant values disappeared.
  
  
  CONCLUSIONS
  Thus thinner abuse relates with slowing of POF in the EEG of patients with thinner abuse associated with disorganization, and asymmetry depending on time of abuse.
authors.affiliation: Laboratory of Cognitive Neurophysiology, National Institute of Rehabilitation, Mexico City, Mexico. drthinner@starmedia.com
authors.forename: Adrián
authors.initials: A
authors.lastname: Poblano
authors.forename: Blanca
authors.initials: B
authors.lastname: Flores
authors.forename: Carmina
authors.initials: C
authors.lastname: Arteaga
authors.forename: Teodoro
authors.initials: T
authors.lastname: Flores
authors.forename: Yolanda
authors.initials: Y
authors.lastname: Elías
authors.forename: Guadalupe
authors.initials: G
authors.lastname: Pineda
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D002540:Cerebral Cortex / Q000187:drug effects / Q000503:physiopathology*; D002648:Child; D002908:Chronic Disease; D004569:Electroencephalography / Q000187:drug effects; D005260:Female; D006801:Humans; D008297:Male; D012997:Solvents / Q000633:toxicity*; D019966:Substance-Related Disorders / Q000503:physiopathology*
chemical_list: D012997:Solvents