title: Derivative (14)t(11;14)(q13;q32)t(11;14)(p11.2;p11.2): a novel unbalanced variant of the t(11;14)(q13;q32) translocation in mantle cell lymphoma.
abstract: We report the case of a 62-year-old man who presented with splenomegaly, leukocytosis, anemia, and thrombocytopenia. Examination of the peripheral blood, bone marrow, and spleen revealed involvement by mantle cell lymphoma, with some blastoid features and an atypical phenotype. Spleen and bone marrow classical chromosome analysis followed by fluorescence in situ hybridization revealed a novel and unusual unbalanced variant of the t(11;14)(q13;q32) translocation, resulting in a complex derivative chromosome harboring the IGH/CCND1 fusion gene. This chromosome was designated as der(14)t(11;14)(q13;q32)t(11;14)(p11.1;p11.2).
authors.affiliation: Pittsburgh Cytogenetics Laboratory, Magee-Womens Hospital, University of Pittsburgh Medical Center Health System, 300 Halket Street, Pittsburgh, PA 15213, USA.
authors.forename: Malini
authors.initials: M
authors.lastname: Sathanoori
authors.forename: Sofia
authors.initials: S
authors.lastname: Shekhter-Levin
authors.forename: Stanley M
authors.initials: SM
authors.lastname: Marks
authors.forename: Steven H
authors.initials: SH
authors.lastname: Swerdlow
mesh_terms: D022981:Allelic Imbalance; D019046:Bone Marrow Neoplasms / Q000235:genetics; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics*; D002883:Chromosomes, Human, Pair 14 / Q000235:genetics*; D019938:Cyclin D1 / Q000235:genetics; D014644:Genetic Variation; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics; D020522:Lymphoma, Mantle-Cell / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D015514:Oncogene Proteins, Fusion / Q000235:genetics; D013160:Splenic Neoplasms / Q000235:genetics; D014178:Translocation, Genetic
chemical_list: D007143:Immunoglobulin Heavy Chains; D015514:Oncogene Proteins, Fusion; D019938:Cyclin D1