[Effects of DSF on the NO system level in experimental rats of myocardial ischemia].
OBJECTIVE
To observe the effect of DSF on NO System in experimental myocardial ischemia model by ligating the cornary descending branch.


METHODS
Wistar mice were divided into control group, model group, Danshen group and DSF group to observe the effect of DSF on variations of the NO system.


RESULTS
Compared with model group, content of NO, NOS and cNOS in serum and muscle in DSF group were significantly increased (P < 0.05 [Chinese character: see text] P < 0.01). But there was no statisical difference on the content of iNOS (P > 0.05) compared with model group. The expression of cNOS mRNA was increased (P < 0.05).


CONCLUSIONS
The mechanism of DSF in treating coronary is realized by improving the content of NO, the activity of NOS and expression of cNOS mRNA in myocardial tissue.
Tan
Rui
R
Department of Bioengineering, Southwest Jiaotong University, Chengdu 610051, China.
Gu
Jian
J
Liu
Ru
R
Long
Shao-jiang
SJ
D000818:Animals; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D007150:Immunohistochemistry; D008297:Male; D017202:Myocardial Ischemia / Q000097:blood* / Q000378:metabolism / Q000473:pathology; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology; D009569:Nitric Oxide / Q000096:biosynthesis / Q000097:blood*; D019001:Nitric Oxide Synthase / Q000096:biosynthesis / Q000097:blood / Q000235:genetics; D012333:RNA, Messenger / Q000096:biosynthesis; D051381:Rats; D017208:Rats, Wistar; D027561:Salvia miltiorrhiza / Q000737:chemistry*
D004365:Drugs, Chinese Herbal; D012333:RNA, Messenger; D009569:Nitric Oxide; D019001:Nitric Oxide Synthase