title: Early inflammation in the airways of a cystic fibrosis foetus.
abstract: In cystic fibrosis patients, inflammation is often considered to be secondary to chronic infections. In the present study, we show increased levels of pro-inflammatory proteins in the lungs of a cystic fibrosis foetus compared to the lungs of two normal foetuses. Our findings suggest therefore the existence of an early intrinsic pro-inflammatory state in cystic fibrosis airways.
authors.affiliation: Department of Human Genetics, Center for Biomedical Integrative Genoproteomics (CBIG), University of Liege, CHU Sart-Tilman B35, B-4000 Liege, Belgium.
authors.forename: Catherine
authors.initials: C
authors.lastname: Verhaeghe
authors.forename: Katty
authors.initials: K
authors.lastname: Delbecque
authors.forename: Laurence
authors.initials: L
authors.lastname: de Leval
authors.forename: Cecile
authors.initials: C
authors.lastname: Oury
authors.forename: Vincent
authors.initials: V
authors.lastname: Bours
mesh_terms: D015415:Biomarkers / Q000378:metabolism; D001991:Bronchitis / Q000196:embryology* / Q000378:metabolism / Q000473:pathology; D003550:Cystic Fibrosis / Q000196:embryology* / Q000378:metabolism / Q000473:pathology; D016207:Cytokines / Q000378:metabolism*; D005260:Female; D005315:Fetal Diseases / Q000378:metabolism* / Q000473:pathology; D005455:Fluorescent Antibody Technique; D005865:Gestational Age; D006801:Humans; D007150:Immunohistochemistry; D008168:Lung / Q000378:metabolism / Q000473:pathology; D018613:Microscopy, Confocal; D016328:NF-kappa B / Q000378:metabolism*; D011247:Pregnancy; D011256:Pregnancy Outcome
chemical_list: D015415:Biomarkers; D016207:Cytokines; D016328:NF-kappa B