Metal release from stainless steel particles in vitro-influence of particle size.
Human inhalation of airborne metallic particles is important for health risk assessment. To study interactions between metallic particles and the human body, metal release measurements of stainless steel powder particles were performed in two synthetic biological media simulating lung-like environments. Particle size and media strongly influence the metal release process. The release rate of Fe is enhanced compared with Cr and Ni. In artificial lysosomal fluid (ALF, pH 4.5), the accumulated amounts of released metal per particle loading increase drastically with decreasing particle size. The release rate of Fe per unit surface area increases with decreasing particle size. Compared with massive sheet metal, fine powder particles (<4 microm) show similar release rates of Cr and Ni, but a higher release rate of Fe. Release rates in Gamble's solution (pH 7.4), for all powders investigated, are significantly lower compared to ALF. No clear trend is seen related to particle size in Gamble's solution.
Midander
K
K
Division of Corrosion Science, Department of Materials Science and Engineering, School of Industrial Engineering and Management, Royal Institute of Technology, SE-100 44 Stockholm, Sweden. klarami@kth.se
Pan
J
J
Wallinder
I Odnevall
IO
Leygraf
C
C
D002857:Chromium / Q000032:analysis / Q000737:chemistry; D004781:Environmental Exposure / Q000032:analysis; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007501:Iron / Q000032:analysis / Q000737:chemistry; D007700:Kinetics; D019216:Metals, Heavy / Q000032:analysis* / Q000737:chemistry; D008855:Microscopy, Electron, Scanning; D009532:Nickel / Q000032:analysis / Q000737:chemistry; D010316:Particle Size; D013193:Stainless Steel / Q000737:chemistry*
D019216:Metals, Heavy; D002857:Chromium; D013193:Stainless Steel; D009532:Nickel; D007501:Iron