title: Restricted diffusion in Canavan disease.
abstract: BACKGROUND
  Canavan disease is a megalencephalic leukodystrophy due to deficiency of the enzyme aspartoacylase. Proton MR spectroscopy finding of elevated N-acetyl-L: -aspartate is considered diagnostic of Canavan disease.
  
  
  METHODS
  We report a case of Canavan disease, which showed restricted diffusion in diffusion-weighted imaging and discuss the cause of it.
authors.affiliation: Department of Neuroimaging and Interventional Radiology, National Institute of Mental Health and Neurosciences, Bangalore, India. sgsrikanth@yahoo.com
authors.forename: S G
authors.initials: SG
authors.lastname: Srikanth
authors.forename: H S
authors.initials: HS
authors.lastname: Chandrashekar
authors.forename: K
authors.initials: K
authors.lastname: Nagarajan
authors.forename: P N
authors.initials: PN
authors.lastname: Jayakumar
mesh_terms: D000581:Amidohydrolases / Q000378:metabolism; D001224:Aspartic Acid / Q000378:metabolism; D017825:Canavan Disease / Q000175:diagnosis* / Q000378:metabolism; D038524:Diffusion Magnetic Resonance Imaging; D006801:Humans; D007223:Infant; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008297:Male
chemical_list: D001224:Aspartic Acid; D000581:Amidohydrolases; C019751:aspartoacylase