title: Cell death by incompatibility in the fungus Podospora.
abstract: Filamentous fungi are naturally able of somatic fusions. When cells of unlike genotype at specific het loci fuse, non-self recognition operates in the fusion cell and a cell death reaction termed cell death by incompatibility is triggered. In Podospora anserina cell death by incompatibility is characterized by a dramatic vacuolar enlargement, induction of autophagy and cell lysis. Autophagy contributes neither to vacuolar morphological changes nor to cell death but rather protects cells against death. Autophagy could be involved in selective elimination of pro-death signals. Vacuole collapse and cytoplasm acidification might be the cause of cell death by incompatibility.
authors.affiliation: Laboratoire de Génétique Moléculaire des Champignons, Institut de Biochimie et de Génétique Cellulaires, UMR 5095 CNRS et Université de Bordeaux 2, Bordeaux, France.
authors.forename: Bérangère
authors.initials: B
authors.lastname: Pinan-Lucarré
authors.forename: Mathieu
authors.initials: M
authors.lastname: Paoletti
authors.forename: Corinne
authors.initials: C
authors.lastname: Clavé
mesh_terms: D001343:Autophagy; D016923:Cell Death / Q000502:physiology; D005656:Fungal Proteins / Q000235:genetics / Q000378:metabolism*; D015966:Gene Expression Regulation, Fungal; D048468:Podospora / Q000235:genetics / Q000254:growth & development* / Q000378:metabolism; D014617:Vacuoles
chemical_list: D005656:Fungal Proteins