title: Two randomized studies demonstrate the efficacy and safety of dapsone gel, 5% for the treatment of acne vulgaris.
abstract: BACKGROUND
  A new aqueous gel formulation of dapsone has been developed that allows clinically-effective doses of dapsone to be administered topically with minimal systemic absorption.
  
  
  OBJECTIVE
  The goal of these studies was to evaluate the efficacy and safety of dapsone gel, 5% in the treatment of acne.
  
  
  METHODS
  Patients 12 years of age and older with acne vulgaris (N = 3010) participated in two identically-designed 12-week, randomized, double-blind studies of twice-daily monotherapy with dapsone gel, 5%, versus a vehicle gel.
  
  
  RESULTS
  Dapsone gel-treated patients achieved superior results in terms of the investigator's global acne assessment (P < .001) and the mean percentage reduction in inflammatory, noninflammatory, and total lesion counts (all, P < .001) at week 12. Reductions in inflammatory lesion counts favoring dapsone gel over vehicle were apparent as early as 2 weeks and reached statistical significance by 4 weeks. No clinically significant changes in laboratory parameters, including hemoglobin, even among glucose-6-phosphate dehydrogenase-deficient patients, were observed. Adverse events were comparable between the treatment groups and rarely led to discontinuation.
  
  
  CONCLUSIONS
  Adjunctive topical treatments and their impact on acne were not studied in this trial.
  
  
  CONCLUSIONS
  Dapsone gel, 5% appears to be an effective, safe, and well-tolerated treatment for acne vulgaris, with a rapid onset of action.
authors.affiliation: Dermatology Consulting Services, High Point, North Carolina, USA. zdraelos@northstate.net
authors.forename: Zoe D
authors.initials: ZD
authors.lastname: Draelos
authors.forename: Eric
authors.initials: E
authors.lastname: Carter
authors.forename: J Michael
authors.initials: JM
authors.lastname: Maloney
authors.forename: Boni
authors.initials: B
authors.lastname: Elewski
authors.forename: Yves
authors.initials: Y
authors.lastname: Poulin
authors.forename: Charles
authors.initials: C
authors.lastname: Lynde
authors.forename: Steven
authors.initials: S
authors.lastname: Garrett
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy* / Q000473:pathology; D000293:Adolescent; D000328:Adult; D000890:Anti-Infective Agents / Q000008:administration & dosage* / Q000009:adverse effects* / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage* / Q000009:adverse effects* / Q000627:therapeutic use; D002648:Child; D003622:Dapsone / Q000008:administration & dosage* / Q000009:adverse effects* / Q000627:therapeutic use; D004311:Double-Blind Method; D005260:Female; D005782:Gels; D006801:Humans; D008297:Male; D016896:Treatment Outcome
chemical_list: D000890:Anti-Infective Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D005782:Gels; D003622:Dapsone