[Study on therapeutic effects of series of muskone on myocardial infarction canines].
OBJECTIVE
To observe the effects of the series of Muskone (the Muskone includes Slender Dutchmanspipe Root, Tumuxiang, and not Slender Dutchmanspipe Root) on myocardial ischemia, myocardial infarction and hematological index in experimental canines, and to explain the pharmacological action and characteristic of its therapeutic effect on ischemic heart disease.


METHODS
The range and degree of myocardial ischemia was evaluated by epicardial electrogram mapping, and the range extent of myocardial infarction was determined by quantitate histology (N-BT staining method). Meanwhile, the changes of ET, TXB2, 6-Keto-PGF1alpha were determined to study the effects of the series of Muskone on myocardial ischemia, myocardial infarction and hematological index in experimental canines.


RESULTS
The series of Muskone can improve myocardial ischemia and infarction in experimental canines, and relieve significantly the degree of myocardial ischemia (Sigma-ST) determined by epicardial electrogram mapping, decrease the range of myocardial ischemia (N-ST) determined by epicardial electrogram mapping and decrease infarction zone determined by N-BT staining method. And it has a significant inhibition on activity of ET induced by myocardial ischemia and infarction, and increases 6-Keto-PGF1alpha and 6-Keto-PGF1alpha/TXB2 induced by myocardial ischemia.


CONCLUSIONS
The series of Muskone has significant therapeutic effect on myocardial infarction.
Zhang
Jin-Yan
JY
Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China.
Ma
Kun
K
Li
Yi kui
Yk
Zhang
Yong-Tao
YT
Wu
Li-Mao
LM
Li
Xiang-Ri
XR
Pan
Li
L
Li
Lian-Da
LD
D015121:6-Ketoprostaglandin F1 alpha / Q000097:blood; D000818:Animals; D030022:Aristolochia / Q000737:chemistry; D003516:Cycloparaffins / Q000302:isolation & purification / Q000494:pharmacology*; D004285:Dogs; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D016232:Endothelins / Q000097:blood; D005260:Female; D038143:Inula / Q000737:chemistry; D008297:Male; D009203:Myocardial Infarction / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D009206:Myocardium / Q000473:pathology; D010946:Plants, Medicinal / Q000737:chemistry; D013929:Thromboxane B2 / Q000097:blood
D003516:Cycloparaffins; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D016232:Endothelins; D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha; C031021:muscone