Current status of transplantation of the small intestine.
The evolution of small bowel transplantation has been significant over the past 20 years to the point at which it can now be considered a viable and often successful option in the treatment of many forms of short bowel syndrome. A refinement of surgical techniques, improved immunosuppression, enhanced understanding of gut immunology, and better treatment and prevention of complications have contributed to a marked improvement in graft and patient survival. Whereas this transplant population is still beset with many potential complications after isolated bowel or multivisceral transplantation and long-term graft survival (like with other solid organ transplants) remains a challenge, the future holds promise for a continuation of the current positive trend of improvement in several areas.
Ruiz
Phillip
P
Department of Pathology, University of Miami, Miami, FL, USA. pruiz@med.miami.edu
Kato
Tomoaki
T
Tzakis
Andreas
A
D000328:Adult; D002648:Child; D006801:Humans; D007410:Intestinal Diseases / Q000401:mortality / Q000601:surgery*; D007414:Intestinal Neoplasms / Q000401:mortality / Q000601:surgery; D007421:Intestine, Small / Q000637:transplantation*; D016019:Survival Analysis; D017741:Survivors; D014184:Transplantation, Homologous / Q000639:trends*