Environmental tobacco smoke exposure and respiratory syncytial virus infection in young children hospitalized with acute lower respiratory tract infection.
OBJECTIVE
The present study was performed to determine the relationship between environmental tobacco smoke (ETS) exposure and acute lower respiratory tract infection (LRI) caused by respiratory syncytial virus (RSV) in children.


METHODS
The authors did the study in 71 children (median age 12 months; 60% male) who were admitted to King Chulalongkorn Memorial Hospital with acute LRI between June and September 2004. 27% had RSV infection.


RESULTS
RSV-LRI required longer duration of oxygen therapy than non RSV-LRI (4.5 +/- 1.7 vs 2.8 +/- 1.3 days; p < 0.001). Desaturation in room air was more common in the former group compared to the latter group (37 vs 11%; p = 0.01). There was no difference in urinary cotinine level between the two groups (median 0.5 vs 0.6 mcg/mg Cr; ns). Among RSV-LRI, those with desaturation had higher urinary cotinine level than those without desaturation (median 0.8 vs 0.0 mcg/mg Cr; p = 0.04).


CONCLUSIONS
ETS exposure was not associated with RSV-LRI but increased the risk of desaturation in these patients.
Sritippayawan
Suchada
S
Division of Pediatric Pulmonology and Critical Care, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Rama IV Rd, Bangkok 10330, Thailand. suchadacu@hotmail.com
Prapphal
Nuanchan
N
Wong
Piansak
P
Tosukhowong
Piyaratana
P
Samransamruajkit
Rujipat
R
Deerojanawong
Jitladda
J
D000208:Acute Disease; D016009:Chi-Square Distribution; D002675:Child, Preschool; D003367:Cotinine / Q000652:urine; D004781:Environmental Exposure; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D016015:Logistic Models; D008297:Male; D010102:Oxygen Inhalation Therapy; D018357:Respiratory Syncytial Virus Infections / Q000453:epidemiology* / Q000628:therapy; D018709:Statistics, Nonparametric; D013785:Thailand / Q000453:epidemiology; D014028:Tobacco Smoke Pollution / Q000009:adverse effects*; D016896:Treatment Outcome
D014028:Tobacco Smoke Pollution; D003367:Cotinine