title: Dynamic genome architecture in the nuclear space: regulation of gene expression in three dimensions.
abstract: The regulation of gene expression is mediated by interactions between chromatin and protein complexes. The importance of where and when these interactions take place in the nucleus is currently a subject of intense investigation. Increasing evidence indicates that gene activation or silencing is often associated with repositioning of the locus relative to nuclear compartments and other genomic loci. At the same time, however, structural constraints impose limits on chromatin mobility. Understanding how the dynamic nature of the positioning of genetic material in the nuclear space and the higher-order architecture of the nucleus are integrated is therefore essential to our overall understanding of gene regulation.
authors.affiliation: Department Biologie II, Ludwig-Maximilians Universität, Grosshadernerstr. 2, Planegg-Martinsried, Germany. christian.lanctot@lrz.uni-muenchen.de
authors.forename: Christian
authors.initials: C
authors.lastname: Lanctôt
authors.forename: Thierry
authors.initials: T
authors.lastname: Cheutin
authors.forename: Marion
authors.initials: M
authors.lastname: Cremer
authors.forename: Giacomo
authors.initials: G
authors.lastname: Cavalli
authors.forename: Thomas
authors.initials: T
authors.lastname: Cremer
mesh_terms: D001692:Biological Transport / Q000502:physiology; D002467:Cell Nucleus / Q000235:genetics* / Q000502:physiology; D002843:Chromatin / Q000235:genetics* / Q000378:metabolism / Q000502:physiology; D005786:Gene Expression Regulation; D016678:Genome / Q000235:genetics*; D046228:Microarray Analysis / Q000379:methods; D008957:Models, Genetic; D009687:Nuclear Proteins / Q000235:genetics* / Q000378:metabolism / Q000502:physiology; D013997:Time Factors; D015533:Transcriptional Activation
chemical_list: D002843:Chromatin; D009687:Nuclear Proteins