title: Comment on "A common genetic variant is associated with adult and childhood obesity".
abstract: Herbert et al. (Reports, 14 April 2006, p. 279) reported an association between the INSIG2 gene variant rs7566605 and obesity in four sample populations, under a recessive model. We attempted to replicate this result in 10,265 Caucasian individuals, combining family-based, case-control, and general population studies, but found no support for a major role of this variant in obesity.
authors.affiliation: CNRS 8090-Institute of Biology, Pasteur Institute, Lille, France. dina@good.ibl.fr
authors.forename: Christian
authors.initials: C
authors.lastname: Dina
authors.forename: David
authors.initials: D
authors.lastname: Meyre
authors.forename: Chantal
authors.initials: C
authors.lastname: Samson
authors.forename: Jean
authors.initials: J
authors.lastname: Tichet
authors.forename: Michel
authors.initials: M
authors.lastname: Marre
authors.forename: Beatrice
authors.initials: B
authors.lastname: Jouret
authors.forename: Marie Aline
authors.initials: MA
authors.lastname: Charles
authors.forename: Beverley
authors.initials: B
authors.lastname: Balkau
authors.forename: Philippe
authors.initials: P
authors.lastname: Froguel
mesh_terms: D000328:Adult; D015992:Body Mass Index; D016022:Case-Control Studies; D002648:Child; D005190:Family; D005260:Female; D005602:France; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics*; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D009765:Obesity / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D044465:White People
chemical_list: C467727:INSIG2 protein, human; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins