title: Lack of association between the fatty acid binding protein 2 (FABP2) polymorphism with obesity and insulin resistance in two aboriginal populations from Chile.
abstract: The aim of this study was to assess the frequency of fatty acid binding protein 2 (FABP2) Ala54Thr genetic polymorphism and to evaluate its association with obesity and insulin resistance in Chilean aboriginal populations. A sample of 96 urban Aymara and 111 urban Mapuche subjects aged 20-80 years were recruited for this cross-sectional study. Glucose, insulin and lipid profile were measured in fasting plasma samples. Insulin resistance was estimated through the HOMA-IR model. FABP2 Ala54Thr genotypes were determined by PCR followed by RFLP analysis. The allele frequency of Thr54 variant was estimated as 18.2% in Aymara subjects, which is one of the lowest reported to date. The corresponding frequency in Mapuche subjects was 31.9% (p<0.002). Regarding genotype-phenotype associations, no significant differences were found in any of the anthropometric or metabolic variables according to Ala54Thr genotypes. After adjustment by BMI and metabolic variables through a logistic regression analysis, the association of the FABP2 polymorphism with ethnic group persisted (Mapuche group: OR=2.37, 95% CI 1.319-4.277, p=0.004) It is unlikely that Ala54Thr polymorphism of the FABP2 gene plays a relevant role in obesity and insulin resistance in Chilean ethnic groups.
authors.affiliation: Department of Public Nutrition Genetic Epidemiology Unit, Institute of Nutrition and Food Technology (INTA), University of Chile, Santiago, P.O. Box 138-11, Chile. fperez@inta.cl
authors.forename: F
authors.initials: F
authors.lastname: Pérez-Bravo
authors.forename: M
authors.initials: M
authors.lastname: Fuentes
authors.forename: B
authors.initials: B
authors.lastname: Angel
authors.forename: H
authors.initials: H
authors.lastname: Sanchez
authors.forename: E
authors.initials: E
authors.lastname: Carrasco
authors.forename: J L
authors.initials: JL
authors.lastname: Santos
authors.forename: L
authors.initials: L
authors.lastname: Lera
authors.forename: C
authors.initials: C
authors.lastname: Albala
mesh_terms: D019943:Amino Acid Substitution; D001794:Blood Pressure; D002677:Chile; D005215:Fasting; D050556:Fatty Acid-Binding Proteins / Q000235:genetics*; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007199:Indians, South American / Q000235:genetics*; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance / Q000235:genetics*; D016017:Odds Ratio; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D014280:Triglycerides / Q000097:blood
chemical_list: C493404:FABP2 protein, human; D050556:Fatty Acid-Binding Proteins; D007328:Insulin; D014280:Triglycerides