title: Synthesis and antibacterial activity of new 7-piperazinyl-quinolones containing a functionalized 2-(furan-3-yl)ethyl moiety.
abstract: A number of 7-piperazinylquinolones carrying a functionalized 2-(furan-3-yl)ethyl moiety attached to the piperazine ring have been synthesized and evaluated as antibacterial agents against a panel of Gram-positive and Gram-negative bacteria. Most of the synthesized compounds exhibited significant antibacterial activity, and this activity can be modulated through the nature of the functionality on ethyl spacer attached to piperazine ring and the type of side chain present at the N-1 position of quinolone ring.
authors.affiliation: Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran. aforoumadi@yahoo.com
authors.forename: Alireza
authors.initials: A
authors.lastname: Foroumadi
authors.forename: Negar
authors.initials: N
authors.lastname: Mohammadhosseini
authors.forename: Saeed
authors.initials: S
authors.lastname: Emami
authors.forename: Bahram
authors.initials: B
authors.lastname: Letafat
authors.forename: Mohammad Ali
authors.initials: MA
authors.lastname: Faramarzi
authors.forename: Nasrin
authors.initials: N
authors.lastname: Samadi
authors.forename: Abbas
authors.initials: A
authors.lastname: Shafiee
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D005663:Furans / Q000138:chemical synthesis* / Q000494:pharmacology; D006090:Gram-Negative Bacteria / Q000187:drug effects / Q000254:growth & development; D006094:Gram-Positive Bacteria / Q000187:drug effects / Q000254:growth & development; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010879:Piperazines / Q000138:chemical synthesis* / Q000494:pharmacology; D015363:Quinolones / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D005663:Furans; D010879:Piperazines; D015363:Quinolones