Restricted diffusion in Canavan disease.
BACKGROUND
Canavan disease is a megalencephalic leukodystrophy due to deficiency of the enzyme aspartoacylase. Proton MR spectroscopy finding of elevated N-acetyl-L: -aspartate is considered diagnostic of Canavan disease.


METHODS
We report a case of Canavan disease, which showed restricted diffusion in diffusion-weighted imaging and discuss the cause of it.
Srikanth
S G
SG
Department of Neuroimaging and Interventional Radiology, National Institute of Mental Health and Neurosciences, Bangalore, India. sgsrikanth@yahoo.com
Chandrashekar
H S
HS
Nagarajan
K
K
Jayakumar
P N
PN
D000581:Amidohydrolases / Q000378:metabolism; D001224:Aspartic Acid / Q000378:metabolism; D017825:Canavan Disease / Q000175:diagnosis* / Q000378:metabolism; D038524:Diffusion Magnetic Resonance Imaging; D006801:Humans; D007223:Infant; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008297:Male
D001224:Aspartic Acid; D000581:Amidohydrolases; C019751:aspartoacylase