title: Oral and salivary changes in patients with end stage renal disease (ESRD): a two year follow-up study.
abstract: OBJECTIVE
  To compare oral health, salivary flow rate, xerostomia and thirst in end stage renal disease (ESRD) patients remaining on dialysis treatment and after renal transplantation.
  
  
  METHODS
  Longitudinal observation.
  
  
  METHODS
  ESRD patients recruited from dialysis centres in Amsterdam, The Hague and Utrecht, The Netherlands.
  
  
  METHODS
  At baseline and after two years, salivary flow rates, xerostomia and thirst were determined in 43 ESRD patients. The number of decayed missing filled teeth/surfaces (DMFT/DMFS) was recorded, and periodontal status assessed.
  
  
  RESULTS
  After renal transplantation (n = 20), the salivary flow rate increased significantly from UWS = 0.30 +/- 0.21 ml/min to 0.44 +/- 0.29 ml/min (p <0.001) and the level of xerostomia and thirst decreased. After two years, the percentage of bleeding on probing in dialysis patients (n = 23) decreased from 29.5 +/- 25.4% to 10.3 +/- 12.3%, (p <0.05). No differences in DMFT and DMFS were observed between dialysis and renal transplant patients.
  
  
  CONCLUSIONS
  DMFT, dental plaque, gingival bleeding and periodontal indices did not change remarkably after two years, comparing dialysis and renal transplant patients. Renal transplantation enhances salivary flow and decreases symptoms of xerostomia and thirst, and hence enhances the potential to improve the quality of life of affected individuals.
authors.affiliation: Department of Oral Biochemistry, Academic Centre for Dentistry Amsterdam, Vrije Universiteit, Amsterdam, The Netherlands. bots@filternet.nl
authors.forename: C P
authors.initials: CP
authors.lastname: Bots
authors.forename: H S
authors.initials: HS
authors.lastname: Brand
authors.forename: J H G
authors.initials: JH
authors.lastname: Poorterman
authors.forename: B M
authors.initials: BM
authors.lastname: van Amerongen
authors.forename: M
authors.initials: M
authors.lastname: Valentijn-Benz
authors.forename: E C I
authors.initials: EC
authors.lastname: Veerman
authors.forename: P M
authors.initials: PM
authors.lastname: ter Wee
authors.forename: A V
authors.initials: AV
authors.lastname: Nieuw Amerongen
mesh_terms: D000704:Analysis of Variance; D004245:DMF Index; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000628:therapy; D016030:Kidney Transplantation; D016014:Linear Models; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D012463:Saliva / Q000378:metabolism; D012636:Secretory Rate; D013894:Thirst; D014987:Xerostomia / Q000209:etiology* / Q000628:therapy