title: [Second primary tumors in head and neck cancer].
abstract: BACKGROUND
  The development of second primary tumors (SPT) in patients with head and neck squamous cell carcinoma (HNSCC) has become an increasingly important factor in clinical treatment decisions.
  
  
  OBJECTIVE
  To define favourable clinical characteristics for overall survival, in patients with SP head and neck cancer.
  
  
  METHODS
  Records of 633 patients with SCC treated from 1984 to 2004 were reviewed to describe clinical characteristics of the SPT.
  
  
  RESULTS
  The overall incidence of SPT was 11%. The incidence of the index tumors was as follows: supraglottic cancer 21% and oral cancer 16%. The most common SPT occurred in head and neck area in 47%, lung in 32% and esophagus in 11%. Second primary was associated with a poor 5 years survival in patients with HN-SCC (23 versus 53% in control group).
  
  
  CONCLUSIONS
  Because of the high rate of second primary tumors, protocols including chemoprophylaxis should be investigated. Prevention and early detection are indicated.
authors.affiliation: Servicio de Otorrinolaringología, Hospital Valle del Nalón, Riaño-Langreo. alvarezmarcos@telefonica.net
authors.forename: C A
authors.initials: CA
authors.lastname: Alvarez Marcos
authors.forename: J L
authors.initials: JL
authors.lastname: Llorente Pendás
authors.forename: V
authors.initials: V
authors.lastname: Franco Gutiérrez
authors.forename: M A J A
authors.initials: MA
authors.lastname: Hermsen
authors.forename: M P
authors.initials: MP
authors.lastname: Franco Albalad
authors.forename: H
authors.initials: H
authors.lastname: Fernández Espina
authors.forename: C
authors.initials: C
authors.lastname: Suárez Nieto
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000453:epidemiology* / Q000401:mortality; D006258:Head and Neck Neoplasms / Q000453:epidemiology* / Q000401:mortality; D006801:Humans; D015994:Incidence; D016609:Neoplasms, Second Primary / Q000453:epidemiology* / Q000401:mortality; D015995:Prevalence; D012189:Retrospective Studies; D015996:Survival Rate