Selective use of older adults in right lobe living donor liver transplantation.
Many centers are reluctant to use older donors (>44 years) for adult right-lobe living donor liver transplantation (RLDLT) due to concerns about possible increased morbidity in donors and poorer outcomes in recipients. Since 2000, 130 adult RLDLTs have been performed at our institution. Recipients were divided into those who received a right lobe graft from a donor </=age 44 (n = 89, 68%; median age 30) and those who received a liver graft from a donor age >44 (n = 41, 32%; mean age 52). The two donor and recipient populations had similar demographic and operative profiles. With a median follow-up of 29 months, the severity and number of complications in older donors were similar to those in younger donors. No living donor died. Older donor allografts had initial allograft dysfunction compared to younger donors. Complication rates were similar among recipients in both groups but there was a higher bile duct stricture rate with older donor grafts (27% vs. 12%; p = 0.04). One-year recipient graft survival was 86% for older donors and 85% for younger donors (p = 0.95). Early experience with the use of selected older adults (>44 years) for RLDLT is encouraging, but may be associated with a higher rate of biliary complications in the recipient.
Shah
S A
SA
Multi-Organ Transplant Unit, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Canada.
Cattral
M S
MS
McGilvray
I D
ID
Adcock
L D
LD
Gallagher
G
G
Smith
R
R
Lilly
L B
LB
Girgrah
N
N
Greig
P D
PD
Levy
G A
GA
Grant
D R
DR
D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000367:Age Factors; D000465:Algorithms; D002779:Cholestasis; D051799:Delayed Graft Function; D005260:Female; D006085:Graft Survival; D006801:Humans; D016031:Liver Transplantation / Q000009:adverse effects* / Q000379:methods* / Q000401:mortality; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D012189:Retrospective Studies; D016019:Survival Analysis