Adult neurogenesis as a potential therapy for neurodegenerative diseases.
Neurodegenerative diseases, such as Huntington's disease, Parkinson's disease, Alzheimer's disease, and amyotrophic lateral sclerosis (ALS), are progressive neurological diseases that affect millions of people worldwide. Recent identification and advances in our understanding of multi-potent neural stem cells/progenitors in the mature CNS has raised the possibility that these discoveries can be translated into an effective therapy for degenerative neurological disease.
Jordan
J Dedrick
JD
Institute for Cell Engineering and Department of Neurology, Johns Hopkins University School of Medicine, 733 N. Broadway, BRB706, Baltimore, MD 21205, USA.
Ming
Guo-Li
GL
Song
Hongjun
H
D000328:Adult; D000818:Animals; D002490:Central Nervous System / Q000166:cytology; D006801:Humans; D039902:Multipotent Stem Cells / Q000166:cytology / Q000637:transplantation; D019636:Neurodegenerative Diseases / Q000628:therapy*; D055495:Neurogenesis / Q000502:physiology*; D033581:Stem Cell Transplantation / Q000379:methods