title: Endogenous Alkaloids in Man - Synthesis, Analytics, in vivo Identification, and Medicinal Importance*,1.
abstract: The IN VITRO and IN VIVO condensation of endogenous (or administered) reactive amines and carbonyl compounds is reported, leading to alkaloid-type heterocycles. The spectrum of the presented "mammalian alkaloids" ranges from isoquinoline derivatives, via beta-carbolines, through to thiazolidines, arising from vitamin B (6), chloral, and glyoxylic acid, respectively. Formation of these compounds may occur accidentally, but might also be induced intentionally, as a therapy for metabolic diseases.
authors.affiliation: Institute of Organic Chemistry, University of Würzburg, Am Hubland, D-8700 Würzburg, Federal Republic of Germany.
authors.forename: G
authors.initials: G
authors.lastname: Bringmann
authors.forename: D
authors.initials: D
authors.lastname: Feineis
authors.forename: H
authors.initials: H
authors.lastname: Friedrich
authors.forename: A
authors.initials: A
authors.lastname: Hille