title: Hepcidin in anemia and inflammation in chronic kidney disease.
abstract: Maintaining the correct iron balance is crucial for health. Our understanding of the molecular control of iron metabolism has increased dramatically over the past 5 years due to the discovery of hepcidin. This is a circulating antimicrobial peptide mainly synthesized in the liver, which has been recently proposed as a factor regulating the uptake of dietary iron and its mobilization from macrophages and hepatic stores. Inflammation causes an increase of production of hepcidin, which is a potent mediator of anemia of chronic diseases. Anemia in chronic kidney disease is mainly due to erythropoietin deficiency but these patients often have a chronic inflammatory state. The aim of this review is to summarize the current knowledge dealing with a possible role of hepcidin in iron metabolism and its regulation, particularly in kidney disease. In addition, current methods of determination of hepcidin are reviewed.
authors.affiliation: Department of Nephrology and Transplantology, Medical University, Bialystok, Poland. jolmal@poczta.onet.pl
authors.forename: Jolanta
authors.initials: J
authors.lastname: Malyszko
authors.forename: Michal
authors.initials: M
authors.lastname: Mysliwiec
mesh_terms: D000740:Anemia / Q000378:metabolism*; D023181:Antimicrobial Cationic Peptides / Q000097:blood / Q000378:metabolism / Q000502:physiology*; D002908:Chronic Disease; D064451:Hepcidins; D006801:Humans; D007249:Inflammation / Q000378:metabolism*; D007501:Iron / Q000378:metabolism*; D007674:Kidney Diseases / Q000378:metabolism*; D007676:Kidney Failure, Chronic / Q000378:metabolism; D008954:Models, Biological; D006435:Renal Dialysis
chemical_list: D023181:Antimicrobial Cationic Peptides; C578702:HAMP protein, human; D064451:Hepcidins; D007501:Iron