Screening for liver disease using non-invasive biomarkers (FibroTest, SteatoTest and NashTest) in patients with hyperlipidaemia.
BACKGROUND
Mortality related to complications of cirrhosis is increasing in patients with insulin-resistance factors. Hyperlipidaemic patients have multiple risk factors of insulin resistance. It is impossible to perform liver biopsy in such a large number of hyperlipidaemic patients to identify patients with advanced liver fibrosis or with steatohepatitis (non-alcoholic steatohepatitis, NASH).


OBJECTIVE
To use the non-invasive biomarkers, FibroTest (FT), SteatoTest and NashTest, and to assess the prevalence of advanced liver disease in a large population of hyperlipidaemic patients.


METHODS
A consecutive cohort of hyperlipidaemic patients was followed prospectively in a lipid centre and the sera were analysed retrospectively.


RESULTS
A total of 2834 subjects were included: 1909 hyperlipidaemic patients and 925 blood donors (BD). Advanced fibrosis was identified by FT in 53/1909 (2.8%) hyperlipidaemic patients vs. 0/925 BD (0%) (P < 0.0001); advanced steatosis in 569/1893 hyperlipidaemic patients (30.1%) vs. 8/164 (4.9%) BD (P < 0.0001) and NASH in 132/1893 (7%) vs. 0/164 (0%), respectively (P < 0.0001). There was a highly significant and linear association between the number of metabolic syndrome factors and liver disease prevalence - the highest being for type 2 diabetics: advanced steatosis 66%, NASH 24% and advanced fibrosis 6%. CONCLUSIONS The prevalence of fibrosis, steatosis and NASH in hyperlipidaemic patients appears to be high (3%, 30% and 7%, respectively). Biomarkers could be useful for screening of advanced fibrosis and NASH in patients with several metabolic syndrome factors, to prevent liver mortality.
Ratziu
V
V
APHP Hépatologie GHPS, Paris, France.
Giral
P
P
Munteanu
M
M
Messous
D
D
Mercadier
A
A
Bernard
M
M
Morra
R
R
Imbert-Bismut
F
F
Bruckert
E
E
Poynard
T
T
D015415:Biomarkers / Q000097:blood*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000150:complications; D008107:Liver Diseases / Q000175:diagnosis* / Q000209:etiology; D008111:Liver Function Tests / Q000592:standards*; D008297:Male; D008403:Mass Screening; D008875:Middle Aged; D012307:Risk Factors
D015415:Biomarkers