title: Viral vector-mediated and cell-based therapies for treatment of cystic fibrosis.
abstract: Gene and cell-based therapies are considered to be potentially powerful new approaches for the management of cystic fibrosis (CF) lung disease. Despite tremendous efforts that have been made, especially in studies to understand the obstacles to gene delivery, major challenges to the application of these approaches remain to be solved. This article will review the advancements made and challenges remaining in the development of viral vector-mediated and cell-based approaches to treat patients with CF.
authors.affiliation: Department of Pediatrics, University of Florida, Gainesville, Florida, USA.
authors.forename: Terence R
authors.initials: TR
authors.lastname: Flotte
authors.forename: Philip
authors.initials: P
authors.lastname: Ng
authors.forename: Doug E
authors.initials: DE
authors.lastname: Dylla
authors.forename: Paul B
authors.initials: PB
authors.lastname: McCray
authors.forename: Guoshun
authors.initials: G
authors.lastname: Wang
authors.forename: Jay K
authors.initials: JK
authors.lastname: Kolls
authors.forename: Jim
authors.initials: J
authors.lastname: Hu
mesh_terms: D000256:Adenoviridae / Q000235:genetics; D000818:Animals; D003550:Cystic Fibrosis / Q000628:therapy*; D015316:Genetic Therapy / Q000379:methods* / Q000639:trends; D005822:Genetic Vectors / Q000235:genetics; D006801:Humans; D016086:Lentivirus / Q000235:genetics; D033581:Stem Cell Transplantation / Q000379:methods* / Q000639:trends