Risk of thrombosis in patients with essential thrombocythemia and polycythemia vera according to JAK2 V617F mutation status.
We compared the laboratory and clinical findings of 179 patients with essential thrombocythemia (ET) and 77 with polycythemia vera (PV) classified according to the presence of the JAK2 V617F mutation. A gradient was observed in laboratory values between patients with JAK2 wild-type ET, JAK2 V617F ET and PV (all of whom carried the JAK2 mutation). The rate of thrombotic complications in JAK2-positive ET patients was significantly higher than that in wild-type ET patients and not statistically different from that in PV patients.
Finazzi
Guido
G
Rambaldi
Alessandro
A
Guerini
Vittoria
V
Carobbo
Alessandra
A
Barbui
Tiziano
T
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D005260:Female; D006801:Humans; D053614:Janus Kinase 2 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009154:Mutation; D011087:Polycythemia Vera / Q000150:complications* / Q000235:genetics*; D012306:Risk; D013921:Thrombocytopenia / Q000150:complications* / Q000235:genetics*; D013927:Thrombosis / Q000150:complications* / Q000235:genetics* / Q000473:pathology*
C507924:JAK2 protein, human; D053614:Janus Kinase 2