title: Impaired filterability of erythrocytes from patients with chronic hepatitis C and effects of eicosapentaenoic acid on the filterability.
abstract: Although erythrocyte filterability plays a key role in microcirculation, it is unknown whether the filterability of erythrocytes from patients with chronic hepatitis C (CH-C) is impaired. This study aimed to investigate erythrocyte filterability in CH-C patients in relation to medical treatment. The mean erythrocyte filterability (%) for all 24 patients with CH-C (69.2 +/- 10.8%) was significantly lower than that for 5 normal controls (80.5 +/- 1.7%, P < 0.03). In 8 patients, the combination therapy of ribavirin (RBV) and interferon improved liver function but caused anemia. The filterability after treatment (57.8 +/- 12.8%) was lower than that before treatment (70.8 +/- 9.7%, P < 0.05). Decreased filterability showed no correlation with the mean corpuscular volume or mean corpuscular Hb concentration during treatment, suggesting that the decrease in filterability mainly arises from changes in erythrocyte membrane properties. We investigated the protective effects of eicosapentaenoic acid (EPA) on the RBV-induced anemia. Filterability in 7 responders was markedly improved from 68.4 +/- 4.6% to 77.4 +/- 2.4% (P < 0.001), but not in 3 nonresponders. In the responders, the progression of anemia was restrained. In conclusion, we found an obvious impairment of the filterability of erythrocytes from CH-C patients, further impairment of the filterability induced by oxidative membrane damage caused by RBV leading to hemolytic anemia, and amelioration of the filterability caused by the antioxidative effects of EPA.
authors.affiliation: Second Department of Internal Medicine, Kurume University School of Medicine, Fukuoka, 830-0011, Japan.
authors.forename: Ritsuko
authors.initials: R
authors.lastname: Seki
authors.forename: Takashi
authors.initials: T
authors.lastname: Okamura
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Ide
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Kage
authors.forename: Michio
authors.initials: M
authors.lastname: Sata
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Uyesaka
authors.forename: Toru
authors.initials: T
authors.lastname: Maruyama
mesh_terms: D000328:Adult; D000368:Aged; D000743:Anemia, Hemolytic / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy*; D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use*; D000998:Antiviral Agents / Q000009:adverse effects*; D004359:Drug Therapy, Combination; D015118:Eicosapentaenoic Acid / Q000494:pharmacology / Q000627:therapeutic use*; D004907:Erythrocyte Deformability / Q000187:drug effects*; D004910:Erythrocyte Membrane / Q000187:drug effects; D004912:Erythrocytes / Q000187:drug effects*; D018056:Hemorheology / Q000379:methods; D019698:Hepatitis C, Chronic / Q000097:blood / Q000188:drug therapy*; D006801:Humans; D007370:Interferon Type I / Q000009:adverse effects; D007564:Japan; D008875:Middle Aged; D011994:Recombinant Proteins; D012254:Ribavirin / Q000009:adverse effects; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D000975:Antioxidants; D000998:Antiviral Agents; D007370:Interferon Type I; D011994:Recombinant Proteins; D012254:Ribavirin; D015118:Eicosapentaenoic Acid