title: Beneficial effect of treatment with cyclosporin A in a case of refractory antisynthetase syndrome.
abstract: We report a case of idiopathic inflammatory myopathy accompanied with the presence of anti-Jo1 antibodies and complicated by diffuse parenchymal lung disease (antisynthetase syndrome). Efficacy of different therapeutic agents, including corticosteroids, cyclophosphamide and cyclosporin A, is described. We present beneficial effect of cyclosporin A and corticosteroids regimen, and confirm no benefits of plasmapheresis. An interesting association of the disease onset with toxoplasmosis infection is discussed and difficulties regarding diagnosis of cardiac involvement are addressed. We also review other case reports of this rare disorder of poor prognosis.
authors.affiliation: Department of Nephrology, Transplantology and Internal Medicine, Medical University of Gdańsk, Ul. Debinki 7, 80-294 Gdansk, Poland. maja@amg.gda.pl
authors.forename: Magdalena
authors.initials: M
authors.lastname: Jankowska
authors.forename: Barbara
authors.initials: B
authors.lastname: Butto
authors.forename: Alicja
authors.initials: A
authors.lastname: Debska-Slizień
authors.forename: Bolesław
authors.initials: B
authors.lastname: Rutkowski
mesh_terms: D016572:Cyclosporine / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008025:Ligases / Q000276:immunology; D017563:Lung Diseases, Interstitial / Q000150:complications / Q000188:drug therapy*; D008875:Middle Aged; D009220:Myositis / Q000150:complications / Q000188:drug therapy*; D013577:Syndrome
chemical_list: D007166:Immunosuppressive Agents; D016572:Cyclosporine; D008025:Ligases