title: Infiltrating giant cellular blue naevus.
abstract: BACKGROUND
  Cellular blue naevi (CBN) measure 1-2 cm in diameter and affect the dermis, occasionally extending into the subcutaneous fat. The case of a 14-year-old boy with a giant CBN (GCBN) involving the right half of the face, the jugal mucosa and the lower eyelid with a tumour that had infiltrated the bone and the maxillary and ethmoidal sinuses is reported.
  
  
  METHODS
  Biopsies were taken from the skin, jugal mucosa and maxillary sinus. The following markers were used in the immunohistochemical evaluation: CD34, CD56, HMB-45, anti-S100, A-103, Melan A and MIB-1.
  
  
  RESULTS
  The biopsy specimens showed a biphasic pattern affecting the lower dermis, subcutaneous fat, skeletal muscle, bone, jugal mucosa and maxillary sinus, but there was no histological evidence of malignancy. The tumour cells were CD34-, CD56-, HMB45+, anti-S100+ and A-103+. Melan A was focally expressed. No positive MIB-1 cells were identified.
  
  
  CONCLUSIONS
  The present case shows that GCBN may infiltrate deeply, with no evidence of malignancy.
authors.affiliation: Department of Pathology, Hospital Universitário Prof Edgard Santos, Universidade Federal da Bahia, Bahia, Brazil. achilea@uol.com.br
authors.forename: A L
authors.initials: AL
authors.lastname: Bittencourt
authors.forename: D A
authors.initials: DA
authors.lastname: Monteiro
authors.forename: O J
authors.initials: OJ
authors.lastname: De Pretto
mesh_terms: D000293:Adolescent; D014408:Biomarkers, Tumor / Q000378:metabolism; D001706:Biopsy; D005153:Facial Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D006801:Humans; D008297:Male; D018329:Nevus, Blue / Q000000981:diagnostic imaging / Q000473:pathology*; D012878:Skin Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D014057:Tomography, X-Ray Computed
chemical_list: D014408:Biomarkers, Tumor