title: Growth hormone-IGF-I axis and growth velocity in Chinese children with type 1 diabetes mellitus.
abstract: OBJECTIVE
  To elucidate hormonal disturbances in patients with type 1 diabetes mellitus (DM1) with and without growth retardation.
  
  
  METHODS
  Patients with DM1 were divided into two groups, group A consisted of 14 patients with poor growth, and group B consisted of 24 patients with normal growth. Serum IGF-I, IGFBP-3, basal and stimulated GH, and HbA1c were measured.
  
  
  RESULTS
  Serum IGF-I and IGFBP-3 concentrations were significantly decreased in group A versus both groups B and controls in Tanner stages I-III; in addition, these measurements in group B were significantly lower compared to controls in Tanner stages II and III, but there was no significant difference in prepuberty. Both basal and peak serum GH were attenuated significantly in group A versus group B. Basal serum GH in group B (normal growth DM1) was significantly elevated versus the controls. There was an unambiguous negative linear regression between IGF-I and mean HbA1c in patients with DM1.
  
  
  CONCLUSIONS
  Growth retardation in patients with DM1 is associated with an abnormal GH-IGF-I axis and poor glycemic control.
authors.affiliation: Department of Pediatrics, Clinical Medical College of Shandong University, Shandong Provincial Hospital, China.
authors.forename: Guimei
authors.initials: G
authors.lastname: Li
authors.forename: Gail
authors.initials: G
authors.lastname: Mick
authors.forename: Xudong
authors.initials: X
authors.lastname: Wang
authors.forename: Jiang
authors.initials: J
authors.lastname: Xue
authors.forename: Kenneth
authors.initials: K
authors.lastname: McCormick
mesh_terms: D002648:Child; D003430:Cross-Sectional Studies; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000378:metabolism* / Q000503:physiopathology*; D005260:Female; D005947:Glucose / Q000378:metabolism; D006128:Growth / Q000502:physiology*; D006130:Growth Disorders / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology; D013006:Growth Hormone / Q000378:metabolism*; D006801:Humans; D007031:Hypothalamus / Q000503:physiopathology; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000378:metabolism; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D016014:Linear Models; D008297:Male; D010902:Pituitary Gland / Q000503:physiopathology
chemical_list: D018972:Insulin-Like Growth Factor Binding Protein 3; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone; D005947:Glucose