Isolation, Identification, and Chemical Synthesis of 6alpha-Hydroxyraumacline: A Novel Alkaloid from Cultivated Rauwolfia serpentina Cells.
From RAUWOLFIA SERPENTINA cells cultivated in the presence of ajmaline ( 2) the new indole alkaloid, 6alpha-hydroxyraumacline ( 1), was isolated. This alkaloid also occurs in significant amounts in the nutrition medium. A simple chemical synthesis of 1 was developed starting from ajmaline ( 2).
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Lehrstuhl für Pharmazeutische Biologie der Johannes Gutenberg-Universität Mainz. Institut für Pharmazie. Staudinger Weg5, D(W)-6500 Mainz. Federal Republic of Germany.
Suda
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Takayama
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Aimi
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Sakai
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Stöckigt
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