Human keratinocyte Toll-like receptors promote distinct immune responses.
It has been well established that Toll-like receptors (TLRs) are expressed by keratinocytes and respond to their respective ligands to initiate immune responses. However, it appears that keratinocytes, via differential activation of TLRs, may play a key role in determining the type of subsequent cutaneous immune response generated against a particular pathogen.
Miller
Lloyd S
LS
Division of Dermatology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA. rmodlin@mednet.ucla.edu
Modlin
Robert L
RL
D000917:Antibody Formation / Q000502:physiology*; D006801:Humans; D015603:Keratinocytes / Q000378:metabolism*; D012867:Skin / Q000276:immunology*; D051193:Toll-Like Receptors / Q000502:physiology*
D051193:Toll-Like Receptors