[Comparison of intravenous dipyrone to intravenous metoclopramide in the treatment of acute crisis of migraine: randomized clinical trial].
BACKGROUND
Migraine is one of the commonest diseases of clinical practice.


OBJECTIVE
[corrected] To compare the analgesic effect of dipyrone to metoclopramide in the relief of pain.


METHODS
We conducted a pilot randomized study comparing intravenous dipyrone to intravenous metoclopramide in 27 patients presenting acute crisis of migraine. The primary end point was to compare reduction of intensity of pain up to 2 hours, as well as the development of collateral effects.


RESULTS
The groups had similar ages, but there were difference between the sexes. In men, metoclopramide reduced pain in 80.0% compared with 55.0% from dipyrone (p=0.052). In women, there was a reduction of 65.0% with metoclopramide and 71.2% with dipyrone (p=0.748). The small number of patients in the study might have influenced these results. Significant collateral effects were not found.


CONCLUSIONS
There was no difference about the intensity of pain reduction neither about the development of collateral effects comparing dipyrone to metoclopramide.
Fernandes Filho
Sérgio Murilo Maciel
SM
Setor de Emergência do Hospital Getúlio Vargas, Recife PE, Brasil (HGV). sergiomurilo@yahoo.com
Costa
Márcio Santos
MS
Fernandes
Mariana Torres
MT
Foerster
Miriam Vils
MV
D000208:Acute Disease; D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage* / Q000009:adverse effects; D004177:Dipyrone / Q000008:administration & dosage* / Q000009:adverse effects; D018492:Dopamine Antagonists / Q000008:administration & dosage* / Q000009:adverse effects; D005260:Female; D006801:Humans; D008297:Male; D008787:Metoclopramide / Q000008:administration & dosage* / Q000009:adverse effects; D008881:Migraine Disorders / Q000188:drug therapy*; D010147:Pain Measurement; D010865:Pilot Projects; D012720:Severity of Illness Index; D016896:Treatment Outcome
D000894:Anti-Inflammatory Agents, Non-Steroidal; D018492:Dopamine Antagonists; D004177:Dipyrone; D008787:Metoclopramide