Toward a modern concept of sepsis: new answers to ancient questions.
It is commonly thought that bacterial endotoxin such as lipopolysaccharide (LPS) causes sepsis. Authors argue that LPS is merely a disease marker. The real mechanism of sepsis lies in the Toll-like receptors that suppress sepsis caused by tissue injury or endotoxin. When Toll-like receptors' initial suppression role is overwhelmed, sepsis ensues.
Brunn
Gregory J
GJ
Transplantation Biology and Department of Pharmacology and Experimental Therapeutics, Mayo Clinic College of Medicine, Rochester, MN 55905, USA.
Wijdicks
Marilou F
MF
Platt
Jeffrey L
JL
D000818:Animals; D006801:Humans; D008954:Models, Biological; D018805:Sepsis / Q000209:etiology* / Q000378:metabolism* / Q000503:physiopathology; D018746:Systemic Inflammatory Response Syndrome / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology; D051193:Toll-Like Receptors / Q000235:genetics / Q000378:metabolism / Q000502:physiology
D051193:Toll-Like Receptors