title: Inositol polyphosphate kinases: regulators of nuclear function.
abstract: Recent work has uncovered roles for inositide signalling pathways downstream of phospholipase C activation and inositol 1,4,5-trisphosphate in the regulation of nuclear processes including gene expression, mRNA export and DNA metabolism. The identification of several IPKs (inositol polyphosphate kinases) has renewed interest in the cellular roles of inositol tetra-, penta-, hexa- and pyro-phosphates. Discoveries of inositide receptors and novel mechanisms of inositide action have provided important insights into how such messengers couple to nuclear machinery. In this chapter, we discuss the IPK family members and the nuclear processes that their inositide products regulate.
authors.affiliation: Department of Pharmacology and Cancer Biology, Howard Hughes Medical Institute, Duke University Medical Center, DUMC 3813, Durham NC 27710, USA.
authors.forename: Andrew M
authors.initials: AM
authors.lastname: Seeds
authors.forename: John D
authors.initials: JD
authors.lastname: York
mesh_terms: D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism*; D006801:Humans; D007295:Inositol Phosphates / Q000378:metabolism*; D008954:Models, Biological; D017856:Phosphotransferases (Phosphate Group Acceptor) / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D007295:Inositol Phosphates; D017856:Phosphotransferases (Phosphate Group Acceptor); C022424:polyphosphate kinase