title: Insulin-like growth factor-1, leptin, body composition, and clinical status interactions in children with cystic fibrosis.
abstract: OBJECTIVE
  Children with cystic fibrosis (CF) are of increased risk of reduced fat body mass (FBM) and lean body mass (LBM). Serum concentrations of insulin-like growth factor-1 (IGF-1)and leptin could be markers of LBM and/or FBM depletion. To evaluate the relationships between disease activity, body composition, IGF-1 and leptin concentrations in CF children.
  
  
  METHODS
  A cross-sectional study with 26 CF children aged 5.0-15.5 years and 33 healthy controls, mean age 9.4 years. Body composition was evaluated by dual-energy X-ray absorptiometry. Fasting blood samples were analyzed for leptin, IGF-1 and IGFBP-3.
  
  
  RESULTS
  FBM standard deviation score (SDS; CF boys -0.02 +/- 0.88 vs. 0.78 +/- 0.65, p < 0.01; CF girls -0.37 +/- 1.15 vs. 0.70 +/- 0.97, p < 0.05), leptin concentration (CF boys 2.07 +/- 0.79 vs. 3.07 +/- 1.28 ng/ml, p < 0.05; CF girls 2.71 +/- 0.86 vs. 5.00 +/- 2.95 ng/ml, p < 0.05) and IGF-1SDS (CF boys -1.43 +/- 1.50 vs. -0.32 +/- 0.88, p < 0.05; CF girls -0.66 +/- 1.66 vs. 0.64 +/- 0.57, p < 0.01) were lower in CF children compared to controls. Shwachman score was the strongest predictor of lean body mass (R = 0.63). Leptin levels explain 60% of the variability in FBM.
  
  
  CONCLUSIONS
  Serum concentrations of IGF-1 and leptin are decreased in children with CF and are associated with clinical conditions and body composition.
authors.affiliation: Pediatric Endocrinology Unit, Department of Pediatrics, Hospital de Clínicas, Federal University of Paraná, Curitiba, Brazil. margabogus@bol.com.br
authors.forename: Margaret C S
authors.initials: MC
authors.lastname: Boguszewski
authors.forename: Tsukiyo Obu
authors.initials: TO
authors.lastname: Kamoi
authors.forename: Rosana
authors.initials: R
authors.lastname: Bento Radominski
authors.forename: Cesar Luiz
authors.initials: CL
authors.lastname: Boguszewski
authors.forename: Sten
authors.initials: S
authors.lastname: Rosberg
authors.forename: Nelson Augusto Rosário
authors.initials: NA
authors.lastname: Filho
authors.forename: Romolo
authors.initials: R
authors.lastname: Sandrini Neto
authors.forename: Kerstin
authors.initials: K
authors.lastname: Albertsson-Wikland
mesh_terms: D000273:Adipose Tissue / Q000033:anatomy & histology; D000293:Adolescent; D015415:Biomarkers / Q000097:blood; D001823:Body Composition; D002648:Child; D002657:Child Development; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D003550:Cystic Fibrosis / Q000097:blood*; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood; D007334:Insulin-Like Growth Factor I / Q000032:analysis*; D020738:Leptin / Q000097:blood*; D008297:Male
chemical_list: D015415:Biomarkers; D020738:Leptin; D007334:Insulin-Like Growth Factor I