title: Event related brain potentials in elderly patients with recently diagnosed isolated systolic hypertension.
abstract: OBJECTIVE
  Isolated Systolic Hypertension (ISH) is a known risk factor for cognitive impairment, but the time of onset of neurocognitive changes relative to the onset of ISH has yet to be established. The purpose of this study was to investigate the relationship between systolic BP values and neurocognitive function in the early stages of ISH.
  
  
  METHODS
  Twenty elderly patients with recently (< 2 years) diagnosed ISH and 10 elderly normotensive controls underwent Ambulatory Blood Pressure Monitoring (ABPM) and neurocognitive assessment, performed using the Mini Mental State Examination (MMSE), and the recording of ERPs with an odd ball acoustic paradigm.
  
  
  RESULTS
  There were no significant differences in MMSE scores or in the P300 latency between ISH patients and controls. The N2 latency was significantly higher in ISH patients vs. controls (p<0.0001), and showed a significant association with both clinical and ambulatory systolic BP and pulse pressure values in the overall study population.
  
  
  CONCLUSIONS
  These findings suggest the existence of early subclinical alterations in neurocognitive function in early ISH, detectable through ERPs.
  
  
  CONCLUSIONS
  Our findings underscore the ISH may constitute a threat to neurocognitive health in the elderly.
authors.affiliation: Department of Geriatrics, 1st Institute of Medicine, La Sapienza University, Rome, Italy. paolo.cicconetti@uniroma1.it
authors.forename: Paolo
authors.initials: P
authors.lastname: Cicconetti
authors.forename: Veronica
authors.initials: V
authors.lastname: Ciotti
authors.forename: Laura
authors.initials: L
authors.lastname: Tafaro
authors.forename: Evaristo
authors.initials: E
authors.lastname: Ettorre
authors.forename: Flavia
authors.initials: F
authors.lastname: Chiarotti
authors.forename: Carolina
authors.initials: C
authors.lastname: Priami
authors.forename: Mauro
authors.initials: M
authors.lastname: Cacciafesta
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Marigliano
mesh_terms: D000368:Aged; D001794:Blood Pressure / Q000502:physiology; D001921:Brain / Q000503:physiopathology*; D004569:Electroencephalography / Q000379:methods; D005071:Evoked Potentials / Q000502:physiology*; D005260:Female; D015577:Geriatric Assessment; D006801:Humans; D006973:Hypertension / Q000473:pathology / Q000503:physiopathology*; D008297:Male; D015999:Multivariate Analysis; D009483:Neuropsychological Tests; D011930:Reaction Time / Q000502:physiology; D018709:Statistics, Nonparametric