title: In vitro inhibition of Streptococcus mutans biofilm formation on hydroxyapatite by subinhibitory concentrations of anthraquinones.
abstract: We report that certain anthraquinones (AQs) reduce Streptococcus mutans biofilm formation on hydroxyapatite at concentrations below the MIC. Although AQs are known to generate reactive oxygen species, the latter do not underlie the observed effect. Our results suggest that AQs inhibit S. mutans biofilm formation by causing membrane perturbation.
authors.affiliation: Laboratorium voor Farmaceutische Microbiologie, Universiteit Gent, Harelbekestraat 72, B-9000 Gent, Belgium. Tom.Coenye@UGent.be
authors.forename: Tom
authors.initials: T
authors.lastname: Coenye
authors.forename: Kris
authors.initials: K
authors.lastname: Honraet
authors.forename: Petra
authors.initials: P
authors.lastname: Rigole
authors.forename: Pol
authors.initials: P
authors.lastname: Nadal Jimenez
authors.forename: Hans J
authors.initials: HJ
authors.lastname: Nelis
mesh_terms: D000880:Anthraquinones / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D018441:Biofilms / Q000187:drug effects* / Q000254:growth & development; D017886:Durapatite / Q000378:metabolism; D008826:Microbial Sensitivity Tests; D013295:Streptococcus mutans / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism
chemical_list: D000880:Anthraquinones; D000900:Anti-Bacterial Agents; D017886:Durapatite