title: Complete reversal of glycogen hepatopathy with pancreas transplantation: two cases.
abstract: Glycogen hepatopathy is the pathological overloading of hepatocytes with glycogen that is associated with poorly controlled diabetes mellitus. Clinically, it presents with abdominal discomfort, tender hepatomegaly and elevated transaminases. In this report, we describe our experience with two cases of type I diabetes mellitus and glycogen hepatopathy. The patients underwent isolated pancreas transplantation, following which, we have been able to demonstrate complete histological resolution of glycogen hepatopathy associated with control of glucose metabolism.
authors.affiliation: Department of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA. jfridell@iupui.edu
authors.forename: Jonathan A
authors.initials: JA
authors.lastname: Fridell
authors.forename: Romil
authors.initials: R
authors.lastname: Saxena
authors.forename: Naga P
authors.initials: NP
authors.lastname: Chalasani
authors.forename: William C
authors.initials: WC
authors.lastname: Goggins
authors.forename: John A
authors.initials: JA
authors.lastname: Powelson
authors.forename: Oscar W
authors.initials: OW
authors.lastname: Cummings
mesh_terms: D000293:Adolescent; D000328:Adult; D001706:Biopsy; D001786:Blood Glucose / Q000378:metabolism; D003922:Diabetes Mellitus, Type 1 / Q000601:surgery; D005260:Female; D006008:Glycogen Storage Disease / Q000209:etiology / Q000473:pathology*; D006801:Humans; D008107:Liver Diseases / Q000209:etiology / Q000473:pathology*; D008297:Male; D016035:Pancreas Transplantation / Q000009:adverse effects*; D012086:Reoperation
chemical_list: D001786:Blood Glucose