title: Regional cerebral blood flow abnormalities in patients with primary hyperparathyroidism.
abstract: BACKGROUND
  We assessed the alterations in regional cerebral blood flow (rCBF) in patients with primary hyperparathyroidism (PHP) before parathyroidectomy by semiquantitative analysis of brain single photon emission computed tomography (SPECT) images.
  
  
  METHODS
  Included in this prospective study were 14 patients (mean age 47.6 +/- 10.4 years; 3 male, 11 female) and 10 control subjects (mean age 36.0 +/- 8.5 years, 6 male, 4 female) were SPECT imaging was performed using a dual-headed gamma camera 60-90 min after intravenous administration of 925 MBq Tc-99m HMPAO. The corticocerebellar rCBF ratios were calculated from 52 brain areas and reference lower values (RLVs) were calculated from the rCBF ratios of control subjects. The regional ratios that were below the corresponding RLV were considered abnormal (hypoperfused).
  
  
  RESULTS
  Hypoperfusion was shown in 171 out of 728 regions (23%) and there was a significant correlation between serum calcium, PTH levels and the sum of hypoperfused regions in the patient group (R = 0.75 and P = 0.001, and R = 0.75, P = 0.001, respectively). Significantly reduced rCBF were found in the following cortical regions: bilateral cingulate cortex, superior and inferior frontal cortex, anterior temporal cortex, precentral gyrus, postcentral gyrus and parietal cortex, and right posterior temporal cortex.
  
  
  CONCLUSIONS
  Our results indicate that alterations in rCBF in patients with PHP can be demonstrated with brain SPECT. The correlation between serum calcium, PTH levels and the sum of hypoperfused regions indicates that there may be a strong relationship between rCBF abnormalities and increased levels of serum calcium and PTH. In addition, the degree of rCBF abnormalities could be determined by brain SPECT in PHP patients with or without psychiatric symptoms.
authors.affiliation: Department of Nuclear Medicine, Hospital of the University of Trakya, Edirne, Turkey.
authors.forename: Tevfik Fikret
authors.initials: TF
authors.lastname: Cermik
authors.forename: Meryem
authors.initials: M
authors.lastname: Kaya
authors.forename: Betül
authors.initials: B
authors.lastname: Uğur-Altun
authors.forename: Deniz
authors.initials: D
authors.lastname: Bedel
authors.forename: Sakir
authors.initials: S
authors.lastname: Berkarda
authors.forename: Omer N
authors.initials: ON
authors.lastname: Yiğitbaşi
mesh_terms: D000328:Adult; D002560:Cerebrovascular Circulation; D005260:Female; D006801:Humans; D049950:Hyperparathyroidism, Primary / Q000000981:diagnostic imaging* / Q000503:physiopathology* / Q000601:surgery; D007091:Image Processing, Computer-Assisted; D008297:Male; D008875:Middle Aged; D019275:Radiopharmaceuticals; D012039:Regional Blood Flow / Q000502:physiology; D018709:Statistics, Nonparametric; D019690:Technetium Tc 99m Exametazime; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D019275:Radiopharmaceuticals; D019690:Technetium Tc 99m Exametazime