Study of the correlation between blood lipid levels and the severity of coronary atherosclerosis in a Chinese population sample.
OBJECTIVE
To investigate the relationship between blood lipid levels with severity of coronary artery atherosclerosis in a Chinese population sample.


RESULTS
According to coronary angiography results, 363 patients (287 men and 76 women) with coronary artery atherosclerosis were divided into four groups: the single-vessel group (I, n = 125), the double-vessel group (II, n = 113), the triple-vessel group (III, n = 107) and the multi-vessel group (IV, n = 18). The severity of coronary artery atherosclerosis was quantified with a modified Gensini score on the basis of angiographic imaging. Serum triglycerides (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), non-high density lipoprotein cholesterol (non-HDL-C) were measured before angiography in all groups. Levels of serum TC, LDL-C and non-HDL-C of the II, III and IV group were significantly higher than those of the I group (4.78 +/- 0.82 mmol/L and 4.87 +/- 1.50 mmol/L and 4.73 +/- 0.99 mmol/L vs. 4.38 +/- 0.93 mmol/L, 2.91 +/- 0.68 mmol/L and 2.74 +/- 1.23 mmol/L and 2.64 +/- 0.84 mmol/L vs. 2.30 +/- 0.77 mmol/L, 3.58 +/- 0.75 mmol/L and 3.59 +/- 1.41 mmol/L and 3.43 +/- 0.94 mmol/L vs. 3.17 +/- 0.91 mmol/L; p < 0.05); the mean levels of TC, LDL-C and non-HDL-C associated positively with the Gensini score.


CONCLUSIONS
Serum lipid levels correlate positively with the severity of coronary artery atherosclerosis in a Chinese population sample. Patients with higher levels of serum TC, LDL-C and non-HDL-C have more severe coronary atherosclerosis, compared with those with low levels of serum TC, LDL-C and non-HDL-C.
Jin
Zhengming
Z
Division of Cardiovascular Disease, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, People's Republic of China.
Zhang
Yun
Y
Chen
Junzhu
J
Zhu
Jianhua
J
Zhang
Furong
F
Qiu
Yuangang
Y
Zhao
Lili
L
D002681:China / Q000453:epidemiology; D003324:Coronary Artery Disease / Q000097:blood* / Q000453:epidemiology / Q000473:pathology*; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male
D008055:Lipids