title: Necrobiotic xanthogranuloma successfully treated with autologous stem cell transplantation.
abstract: Paraproteinemia can be complicated by necrobiotic xanthogranuloma. Therapeutic options for this progressive disease are limited, and there is no agreement on a single best strategy. We report the case of a patient with a massive periorbital infiltration narrowing the palpebral fissure and blinding the patient. Conventional myeloma therapy had only limited benefit in our patient. However, he was successfully treated with high-dose chemotherapy followed by autologous stem cell transplantation, rendering the patient free of symptoms. This is the first report of autologous stem cell transplantation in a patient with necrobiotic xanthogranuloma.
authors.forename: Jeroen S
authors.initials: JS
authors.lastname: Goede
authors.forename: Benjamin
authors.initials: B
authors.lastname: Misselwitz
authors.forename: Christian
authors.initials: C
authors.lastname: Taverna
authors.forename: Urs
authors.initials: U
authors.lastname: Schanz
authors.forename: Angela
authors.initials: A
authors.lastname: Dispenzieri
authors.forename: Yvonne
authors.initials: Y
authors.lastname: Hummel
authors.forename: Ralph M
authors.initials: RM
authors.lastname: Trüeb
authors.forename: Jörg
authors.initials: J
authors.lastname: Fehr
mesh_terms: D000328:Adult; D006801:Humans; D008297:Male; D017441:Necrobiotic Disorders / Q000473:pathology / Q000601:surgery*; D012871:Skin Diseases / Q000473:pathology / Q000601:surgery*; D033581:Stem Cell Transplantation / Q000379:methods*; D014182:Transplantation, Autologous; D016896:Treatment Outcome