Anastomotic stenting in a porcine aortoiliac graft model.
The purpose of the study was to evaluate the feasibility of anastomotic stent application in a porcine aortoiliac graft model. In a total of 10 pigs, a polytetrafluoroethylene aortobi-iliac graft was implanted through a midline abdominal incision. The lower edge of the iliac vessel was graft-inverted about 1 mm to produce irregularities at the downstream anastomosis. After transverse graft incision, six stainless-steel stents, six poly-L-lactic acid (PLLA) stents and four PLLA stents with 10% polycaprolactone (PCL) were implanted at the iliac anastomotic site using a 6 mm balloon dilatation catheter. Four anastomotic sites were left untreated. After two weeks, the patency of graft limbs was evaluated by contrast-enhanced computed tomography (CT). Both metal and polymeric stent designs provided adequate flexibility to manoeuvre across the anastomotic site for expansion in the chosen position. After deployment, the stent-arterial wall contact was complete on a macroscopic view. On CT scan, all metal and PLLA-stented graft limbs were free of stenosis, whereas all PLLA/PCL stents were occluded. The non-stented graft limbs showed a stenosis of 50-70%. In summary, this model is feasible to assess preclinically the deployment and patency rate of an anastomotic stent and to test future stent developments.
Bünger
C M
CM
Department of Surgery, University of Rostock, Rostock, Germany. carsten.buenger@medizin.uni-rostock.de
Grabow
N
N
Hauenstein
K
K
Ketner
L
L
Kröger
Chr
C
Sternberg
K
K
Kramer
S
S
Lootz
D
D
Schmitz
K-H
KH
Kreutzer
H J
HJ
Klar
E
E
Schareck
W
W
D000714:Anastomosis, Surgical / Q000295:instrumentation / Q000379:methods*; D000818:Animals; D001011:Aorta / Q000473:pathology / Q000637:transplantation*; D003251:Constriction, Pathologic / Q000473:pathology; D005260:Female; D007083:Iliac Artery / Q000473:pathology / Q000637:transplantation*; D023421:Models, Animal; D015607:Stents; D013552:Swine / Q000601:surgery*; D014057:Tomography, X-Ray Computed