title: Suspected toxic shock-like syndrome in a dog with closed-cervix pyometra.
abstract: Several cases of toxic shock-like syndrome (TSLS) have been reported in dogs but no inciting cause has been identified. TSLS associated with a closed-cervix pyometra was suspected in the reported bitch. The dog was evaluated for the complaint of generalized dermatopathy (erythema and oedema) and systemic signs with multiorganic involvement (depression, fever, immature neutrophilia, hypoalbuminaemia, renal disease, vomiting and diarrhoea). Histological features consistent with TSLS included superficial dermatitis with epidermal neutrophilic exocytosis and necrotic keratinocytes. The tentative diagnosis of TSLS was based on case history, clinical presentation, laboratory and histopathological findings, and the resolution of all clinical signs following surgical removal of the localized bacterial infection.
authors.affiliation: Department of Small Animal Medicine and Clinical Biology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B-9820 Merelbeke, Belgium. jan.declercq.vet@skynet.be
authors.forename: Jan
authors.initials: J
authors.lastname: Declercq
mesh_terms: D000667:Ampicillin / Q000008:administration & dosage / Q000627:therapeutic use; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use; D002584:Cervix Uteri / Q000473:pathology*; D003937:Diagnosis, Differential; D004283:Dog Diseases / Q000175:diagnosis* / Q000473:pathology; D004285:Dogs; D004890:Erythema / Q000209:etiology / Q000662:veterinary*; D005260:Female; D007044:Hysterectomy / Q000662:veterinary; D012772:Shock, Septic / Q000150:complications / Q000175:diagnosis / Q000662:veterinary*; D014591:Uterine Diseases / Q000150:complications / Q000175:diagnosis / Q000628:therapy / Q000662:veterinary*
chemical_list: D000900:Anti-Bacterial Agents; D000667:Ampicillin