Inadequate dietary intake but not renal tubular acidosis is associated with bone demineralization in primary biliary cirrhosis.
BACKGROUND
Metabolic bone disease associated with primary biliary cirrhosis (PBC) is inadequately characterized. Renal tubular acidosis (RTA) may lead to bone loss through chronic mobilization of skeletal calcium salts to buffer increased acid load.


OBJECTIVE
To evaluate the prevalence of RTA in PBC and establish the relationships among bone mineral density (BMD), renal function and nutritional status.


METHODS
We enrolled 69 female patients with compensated PBC and 35 control patients with chronic hepatitis C. RTA was searched in all patients, and 24-h dietary recalls were collected at enrolment. BMD was measured by dual-energy X-ray absorptiometry at the femur neck, lumbar spine and radius ultradistalis sites.


RESULTS
No patients received a diagnosis of RTA. BMD values (Z-scores) showed only little deviation from normal population with no difference between PBC and controls. Osteopoenic PBC patients (T-score < 1) showed significantly lower daily phosphorus intake [median: 672 (288-1374) vs. 921 (253-1923) mg/day; P = 0.037], with a trend towards lower caloric intake than their nonosteopoenic counterparts.


CONCLUSIONS
Renal tubular acidosis is uncommon in compensated PBC. Cholestasis is not associated with an increased risk of bone demineralization. Inadequate dietary intake may be a preventable factor contributing to bone loss in PBC.
Allocca
M
M
Division of Internal Medicine and Liver Unit, Department of Medicine, Surgery and Dentistry, School of Medicine San Paolo, University of Milan, Milan, Italy. mariangela.allocca@tiscali.it
Crosignani
A
A
Gritti
A
A
Benetti
A
A
Zuin
M
M
Podda
M
M
Battezzati
P M
PM
D000141:Acidosis, Renal Tubular / Q000150:complications*; D000328:Adult; D000368:Aged; D015519:Bone Density; D001847:Bone Diseases / Q000150:complications*; D002118:Calcium / Q000652:urine; D016022:Case-Control Studies; D004032:Diet / Q000009:adverse effects*; D002149:Energy Intake; D005260:Female; D006801:Humans; D008105:Liver Cirrhosis, Biliary / Q000150:complications*; D008875:Middle Aged; D010758:Phosphorus / Q000172:deficiency
D010758:Phosphorus; D002118:Calcium