Biosynthesis of the thioquinolobactin siderophore: an interesting variation on sulfur transfer.
The thioquinolobactin siderophore from Pseudomonas fluorescens ATCC 17400 utilizes a variation of the sulfur transfer chemistry found in thiamine and molydobterin biosynthesis. A JAMM motif protein cleaves the C-terminal amino acid residues following a diglycine moiety on a small sulfur carrier protein, and the modified C terminus is activated and sulfurylated, forming a thiocarboxylate.
Godert
Amy M
AM
Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853, USA.
Jin
Mi
M
McLafferty
Fred W
FW
Begley
Tadhg P
TP
D011551:Pseudomonas fluorescens / Q000378:metabolism*; D011804:Quinolines / Q000378:metabolism*; D021241:Spectrometry, Mass, Electrospray Ionization; D013455:Sulfur / Q000378:metabolism*
D011804:Quinolines; C518370:thioquinolobactin; D013455:Sulfur