title: Expression of APOBEC3G in kidney cells.
abstract: The apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 3G (APOBEC3G), a member of the APOBEC family possessing DNA mutator activity through cytosine deamination, is reported to play an important role in host defense against infections such as those of hepatitis B virus and human immunodeficiency virus. Here, we examined the expression of APOBEC3G in human kidney cells to better understand its biological role against infection. APOBEC3G was immunohistochemically detectable in kidney mesangial cells and also to some extent in kidney epithelial tubular cells. In addition, overexpression of APOBEC3G was shown in renal carcinoma tissues and cell lines. APOBEC3G expression was upregulated by inflammatory cytokines, such as interferon, interleukin-6, and tumor necrosis factor. These results may provide new insight into the role of APOBEC3G in host defense against viral infection and cancer.
authors.affiliation: Department of Immunology, Kurume University School of Medicine, Kurume, Fukuoka, Japan. ycomo@med.kurume-u.ac.jp
authors.forename: Y
authors.initials: Y
authors.lastname: Komohara
authors.forename: S
authors.initials: S
authors.lastname: Suekane
authors.forename: M
authors.initials: M
authors.lastname: Noguchi
authors.forename: K
authors.initials: K
authors.lastname: Matsuoka
authors.forename: A
authors.initials: A
authors.lastname: Yamada
authors.forename: K
authors.initials: K
authors.lastname: Itoh
mesh_terms: D000071480:APOBEC-3G Deaminase; D003564:Cytidine Deaminase; D006801:Humans; D018836:Inflammation Mediators / Q000502:physiology; D007372:Interferons / Q000502:physiology; D015850:Interleukin-6 / Q000502:physiology; D007668:Kidney / Q000166:cytology / Q000378:metabolism*; D009700:Nucleoside Deaminases / Q000096:biosynthesis / Q000235:genetics*; D012097:Repressor Proteins / Q000096:biosynthesis / Q000235:genetics*; D014407:Tumor Cells, Cultured; D048069:Tumor Necrosis Factors / Q000502:physiology; D015854:Up-Regulation / Q000502:physiology
chemical_list: D018836:Inflammation Mediators; D015850:Interleukin-6; D012097:Repressor Proteins; D048069:Tumor Necrosis Factors; D007372:Interferons; D009700:Nucleoside Deaminases; D000071480:APOBEC-3G Deaminase; C464924:APOBEC3G protein, human; D003564:Cytidine Deaminase