Synthesis and characterization of electroactive and biodegradable ABA block copolymer of polylactide and aniline pentamer.
A triblock copolymer PLA-b-AP-b-PLA (PAP) of polylactide (PLA) and aniline pentamer (AP) with the unique properties of being both electroactive and biodegradable is synthesized by coupling an electroactive carboxyl-capped AP with two biodegradable bi-hydroxyl-capped PLAs via a condensation reaction. Three different molecule weight PAP copolymers are prepared. The PAP copolymers exhibit excellent electroactivity similar to the AP and polyaniline, which may stimulate cell proliferation and differentiation. The electrical conductivity of the PAP2 copolymer film ( approximately 5x10(-6)S/cm) is in the semiconducting region. Transmission electron microscopic results suggest that there is microphase separation of the two block segments in the copolymer, which might contribute to the observed conductivity. The biodegradation and biocompatibility experiments in vitro prove the copolymer is biodegradable and biocompatible. Moreover, these new block copolymer shows good solubility in common organic solvents, leading to the system with excellent processibility. These biodegradable PAP copolymers with electroactive function thus possess the properties that would be potentially used as scaffold materials for neuronal or cardiovascular tissue engineering.
Huang
Lihong
L
State key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China.
Hu
Jun
J
Lang
Le
L
Wang
Xin
X
Zhang
Peibiao
P
Jing
Xiabin
X
Wang
Xianhong
X
Chen
Xuesi
X
Lelkes
Peter I
PI
Macdiarmid
Alan G
AG
Wei
Yen
Y
D020341:Absorbable Implants; D000814:Aniline Compounds / Q000737:chemistry*; D001672:Biocompatible Materials / Q000737:chemistry*; D001826:Body Fluids / Q000737:chemistry*; D004553:Electric Conductivity; D004563:Electrochemistry / Q000379:methods; D008422:Materials Testing; D008970:Molecular Weight; D044367:Phase Transition; D011091:Polyesters / Q000737:chemistry*
D000814:Aniline Compounds; D001672:Biocompatible Materials; D011091:Polyesters; C033616:poly(lactide)