title: An estrogen metabolism-related polymorphism of the 17-alpha HSD gene is associated with perimenopausal body mass index.
abstract: In a cross-sectional study of 2,802 perimenopausal caucasian women, carriage of at least one mutated allele of the 17-alpha-hydroxysteroid dehydrogenase type 1 (17-alpha HSD) vlV A-->C single nucleotide polymorphism (SNP) was associated with a significantly increased body mass index (mean 24.3 +/- 4.4 kg/m(2) vs. 23.5 +/- 4.2 kg/m(2); P<.001), and obesity was more frequent among mutant allele carriers (P=.06; odds ratio 1.38; 95% confidence interval 0.97-1.95), providing evidence of 17-alpha HSD as a candidate gene of perimenopausal obesity.
authors.affiliation: Department of Gynecologic Endocrinology and Infertility Treatment, Medical University Vienna, Vienna, Austria. clemens.tempfer@meduniwien.ac.at <clemens.tempfer@meduniwien.ac.at>
authors.forename: Clemens B
authors.initials: CB
authors.lastname: Tempfer
authors.forename: Claudia
authors.initials: C
authors.lastname: Huber
authors.forename: Johannes C
authors.initials: JC
authors.lastname: Huber
authors.forename: Christian
authors.initials: C
authors.lastname: Schneeberger
authors.forename: Eva-Katrin
authors.initials: EK
authors.lastname: Bentz
authors.forename: Lukas A
authors.initials: LA
authors.lastname: Hefler
mesh_terms: D015992:Body Mass Index; D003430:Cross-Sectional Studies; D004247:DNA / Q000097:blood / Q000235:genetics / Q000302:isolation & purification; D005260:Female; D005838:Genotype; D006801:Humans; D006913:Hydroxysteroid Dehydrogenases / Q000235:genetics*; D008875:Middle Aged; D010298:Parity; D047648:Perimenopause / Q000235:genetics*; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D011247:Pregnancy
chemical_list: D004247:DNA; D006913:Hydroxysteroid Dehydrogenases; C035507:3(17)-hydroxysteroid dehydrogenase