[Construction recombinant adenovirus vector expressing murine endostatin and inhibition of blood endothelial cells growth].
We constructed recombinant adenovirus vector expressing murine endostatin and evaluated the Inhibition of human umbilical vein endothelial cells (HUVEC). We proved that endostatin significantly suppressed the S phase fraction, inhibited proliferation and increased the apoptotic index of HUVEC.
Zheng
Aiqing
A
Cancer Center, Affiliated Hospital, Tianjin Armed Police Medical University, Tianjin 300070, China.
Song
Xianrang
X
Yu
Jinming
J
Wei
Ling
L
Wang
Xingwu
X
D000256:Adenoviridae / Q000235:genetics* / Q000378:metabolism; D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D043169:Endostatins / Q000096:biosynthesis* / Q000235:genetics; D042783:Endothelial Cells / Q000166:cytology*; D005822:Genetic Vectors / Q000235:genetics; D006801:Humans; D051379:Mice; D011994:Recombinant Proteins / Q000096:biosynthesis* / Q000235:genetics / Q000494:pharmacology; D014471:Umbilical Veins / Q000166:cytology
D043169:Endostatins; D011994:Recombinant Proteins