title: Total synthesis of bistramide A.
abstract: An asymmetric synthesis of the marine metabolite bistramide A is reported. The synthesis relies on the utility of three different organosilane reagents to construct all principle fragments and 8 of the 11 stereogenic centers of the natural product. [structure: see text].
authors.affiliation: Department of Chemistry and Center for Chemical Methodology and Library Development, Metcalf Center for Science and Engineering, Boston University, 590 Commonwealth Avenue, Boston, Massachusetts 02215, USA.
authors.forename: Jason T
authors.initials: JT
authors.lastname: Lowe
authors.forename: Iwona E
authors.initials: IE
authors.lastname: Wrona
authors.forename: James S
authors.initials: JS
authors.lastname: Panek
mesh_terms: D000081:Acetamides / Q000138:chemical synthesis* / Q000737:chemistry; D008968:Molecular Conformation; D011714:Pyrans / Q000138:chemical synthesis* / Q000737:chemistry; D013141:Spiro Compounds / Q000138:chemical synthesis / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000081:Acetamides; D011714:Pyrans; D013141:Spiro Compounds; C059975:bistratene A