Nucleic acids with a six-membered carbohydrate mimic and RNA interference.
Cyclohexenyl nucleic acids and altritol nucleic acids were evaluated as RNA modifications in an siRNA experiment targeting the P-glycoprotein expression. Both modified oligonucleotides are well accepted as RNA mimics leading to an increase in potency and duration of action of the gene-silencing effect.
Herdewijn
Piet
P
The Laboratory of Medicinal Chemistry, Rega Institute for Medical Research, Minderbroedersstraat 10, B-3000 Leuven, Belgium. piet.Herdewijn@rega.kuleuven.ac.be
Juliano
Rudolph
R
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000235:genetics; D002241:Carbohydrates; D020868:Gene Silencing; D018716:Molecular Mimicry; D009696:Nucleic Acids / Q000138:chemical synthesis* / Q000494:pharmacology; D009841:Oligonucleotides / Q000138:chemical synthesis* / Q000494:pharmacology; D034622:RNA Interference
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D002241:Carbohydrates; D009696:Nucleic Acids; D009841:Oligonucleotides