Intravascular lymphomatosis mimicks a cerebral demyelinating disorder.
Intravascular lymphomatosis is a rare extra-nodal form of diffuse, large B-cell non-Hodgkin's lymphoma that causes a myriad of neurological symptoms, including focal neurological deficits, cognitive decline, and seizure. Intravascular lymphomatosis is difficult to make ante-mortem diagnosis because of its variable clinical presentation and non-specific laboratory findings. Neuroimaging findings also vary widely in patients of intravascular lymphomatosis. We present, herein, a patient with rapidly deteriorating neurological deficit whose brain MRI revealed rapidly progressing white matter diseases. This patient was diagnosed and treated as having a cerebral demyelinating disorder. Intravascular lymphomatosis involving multiple organs was finally diagnosed after autopsy.
Liew
Chooi-Lan
CL
Department of Neurology, Buddist Tzu-Chi General Hospital, Tzu-Chi University, Hualien, Taiwan.
Shyu
Woei-Cherng
WC
Tsao
Wen-Long
WL
Li
Hung
H
D001921:Brain / Q000473:pathology; D004673:Encephalomyelitis, Acute Disseminated / Q000175:diagnosis* / Q000209:etiology; D005260:Female; D006801:Humans; D016393:Lymphoma, B-Cell / Q000175:diagnosis* / Q000473:pathology; D016403:Lymphoma, Large B-Cell, Diffuse / Q000175:diagnosis* / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000175:diagnosis* / Q000209:etiology; D019043:Vascular Neoplasms / Q000175:diagnosis*