title: Targeting the messengers of death: the advent of selective activation of apoptosis for cancer therapy.
abstract: Apoptosis is a ubiquitous, highly coordinated process of self-destruction. Conventional cancer therapeutic agents can cause, to a certain degree, apoptosis of cancer cells. However, they do so in an indiscriminate manner leading to unacceptable side effects. Strategies of selectively activating apoptosis of cancer cells are described.
authors.affiliation: Groningen University Institute for Drug Exploration (GUIDE), Department of Pathology and Laboratory Medicine, Section Medical Biology, Laboratory for Tumor Immunology, University Medical Center Groningen, University of Groningen, The Netherlands.
authors.forename: Edwin
authors.initials: E
authors.lastname: Bremer
authors.forename: Wijnand
authors.initials: W
authors.lastname: Helfrich
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D017209:Apoptosis / Q000187:drug effects*; D006801:Humans; D008954:Models, Biological; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology*; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism / Q000502:physiology; D051636:X-Linked Inhibitor of Apoptosis Protein / Q000378:metabolism / Q000502:physiology
chemical_list: D000970:Antineoplastic Agents; D016159:Tumor Suppressor Protein p53; D051636:X-Linked Inhibitor of Apoptosis Protein