Role of neuropeptide Y and its receptors in the progression of endocrine-related cancer.
The neuropeptide Y (NPY) family of peptides, in addition to its many physiological actions, has also been involved in the modulation of tumor progression, with specific reference to endocrine-related cancers such as neuroendocrine tumors, breast and prostate cancers. These have been found either to express NPY receptors, or to secrete NPY-related peptides, or both. The study of the role of the NPY family of peptides in the biology of endocrine-related tumors, specifically concerning cell proliferation, angiogenesis, invasion and metastatization, may help to clarify some aspects of tumor pathophysiology, as well as to indicate novel diagnostic markers and therapeutical approaches.
Ruscica
Massimiliano
M
Center for Endocrinological Oncology, Istituto di Endocrinologia, Università degli Studi di Milano, via Balzaretti 9, Milan 20133, Italy.
Dozio
Elena
E
Motta
Marcella
M
Magni
Paolo
P
D018450:Disease Progression; D004701:Endocrine Gland Neoplasms / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D009478:Neuropeptide Y / Q000502:physiology*; D017476:Receptors, Neuropeptide Y / Q000502:physiology*
D009478:Neuropeptide Y; D017476:Receptors, Neuropeptide Y