Poly(ethylene carbonate): a thermoelastic and biodegradable biomaterial for drug eluting stent coatings?
A first feasibility study exploring the utility of poly(ethylene carbonate) (PEC) as coating material for drug eluting stents under in vitro conditions is reported. PEC (Mw 242 kDa, Mw/Mn=1.90) was found to be an amorphous polymer with thermoelastic properties. Tensile testing revealed a stress to strain failure of more than 600%. These properties are thought to be advantageous for expanding coated stents. In vitro cytotoxicity tests showed excellent cytocompatibility of PEC. Based on these findings, a new stenting concept was suggested, pre-coating a bare-metal stent with PPX-N as non-biodegradable basis and applying a secondary PEC coating using an airbrush method. After manual expansion, no delamination or destruction of the coating could be observed using scanning electron microscopy. The surface degradation-controlled release mechanism of PEC may provide the basis for "on demand" drug eluting stent coatings, releasing an incorporated drug predominantly at an inflamed implantation site upon direct contact with superoxide-releasing macrophages. As a release model, metal plates of a defined size and area were coated under the same conditions as the stents with PEC containing radiolabelled paclitaxel. An alkaline KO(2-) solution served as a superoxide source. Within 12 h, 100% of the incorporated paclitaxel was released, while only 20% of the drug was released in non-superoxide releasing control buffer within 3 weeks.
Unger
F
F
Faculty of Pharmacy, Department of Pharmaceutics and Biopharmacy, Philipps-University, Ketzerbach 63, D-35032 Marburg, Germany.
Westedt
U
U
Hanefeld
P
P
Wombacher
R
R
Zimmermann
S
S
Greiner
A
A
Ausborn
M
M
Kissel
T
T
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology; D001672:Biocompatible Materials; D001711:Biotransformation; D002152:Calorimetry, Differential Scanning; D002470:Cell Survival / Q000187:drug effects; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002850:Chromatography, Gel; D004548:Elasticity; D005347:Fibroblasts / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D008855:Microscopy, Electron, Scanning; D008970:Molecular Weight; D017239:Paclitaxel / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology; D011095:Polyethylenes / Q000737:chemistry*; D015607:Stents; D013718:Tensile Strength; D014961:X-Ray Diffraction
D000972:Antineoplastic Agents, Phytogenic; D001672:Biocompatible Materials; D011095:Polyethylenes; C039212:polyethylene carbonate; D017239:Paclitaxel