title: [A case of polymyositis with concomitant diffuse alveolar damage following interstitial pneumonia].
abstract: A 68-year-old woman had been given a diagnosis of interstitial pneumonia (NSIP pattern) and followed up at our hospital for 3 years. She was admitted to our hospital because of dyspnea, lower limb edema and myalgia. On admission, serum CPK and CRP levels were elevated and an electromyogram suggested inflammatory myopathy. We diagnosed polymyositis (PM) with progressive interstitial pneumonia (IP). Although methylprednisolone pulse therapy and immunosuppressive agents were administered, pulmonary lesions became aggravated. The patient died due to respiratory failure as a result of the progress of IP. The autopsy lung revealed diffuse alveolar damage (DAD) at the both acute and fibrotic phases, suggesting that DAD could coincide with PM. We report here a rare case of polymyositis with diffuse alveolar damage (DAD).
authors.affiliation: The Fourth Department of Internal Medicine, Nippon Medical School.
authors.forename: Akiko
authors.initials: A
authors.lastname: Shingu
authors.forename: Shinji
authors.initials: S
authors.lastname: Abe
authors.forename: Yoshitsugu
authors.initials: Y
authors.lastname: Seo
authors.forename: Nariaki
authors.initials: N
authors.lastname: Kokuho
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Saito
authors.forename: Jiro
authors.initials: J
authors.lastname: Usuki
authors.forename: Arata
authors.initials: A
authors.lastname: Azuma
authors.forename: Tomoko
authors.initials: T
authors.lastname: Nakayama
authors.forename: Yu
authors.initials: Y
authors.lastname: Fukuda
authors.forename: Shoji
authors.initials: S
authors.lastname: Kudo
mesh_terms: D000368:Aged; D004576:Electromyography; D005260:Female; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000150:complications* / Q000473:pathology; D017285:Polymyositis / Q000175:diagnosis / Q000209:etiology*; D011650:Pulmonary Alveoli / Q000473:pathology*; D011658:Pulmonary Fibrosis / Q000209:etiology* / Q000473:pathology