title: Intensity-modulated radiation therapy in head-and-neck cancer, first report in Thailand.
abstract: OBJECTIVE
  This is the first report in Thailand to evaluate the efficacy of using intensity-modulated radiotherapy (IMRT) in the primary treatment of head-and-neck cancer.
  
  
  METHODS
  From July 2005 to March 2006, eighteen patients with head and neck cancer were treated with IMRT, fourteen of which were nasopharyngeal cancer. The median age at diagnosis was 52 years (range 23-58 years). The treatment plan composed of two sequential plans for PTV-low risk (50Gy in 25 fractions) and PTV-high risk (20Gy in 10 fractions). Chemotherapy was given to 13 patients with locoregionally advanced disease (stage T3/T4 and N2/3) using cisplatin (n = 3) or carboplatin (n = 10) every 3 weeks during the course of radiation therapy.
  
  
  RESULTS
  The median overall treatment time was 49 days (range, 43-57 days), and 77.8 percent of the patients completed 35 fractions within 50 days. The clinical complete response and partial response rates at 3 months after complete radiation were 71.4% and 28.6%, respectively. However at the median follow-up of 5.6 months, the complete response rate increased to 89%. Treatment break during RT range from 3 to 7 days, was observed in three patients. All of them received concurrent chemoradiation. No distant metastasis was noted.
  
  
  CONCLUSIONS
  The authors' experience of using concurrent chemotherapy with IMRT for a cohort of patients with head and neck carcinoma showed a very high rate response rate at early follow-up. Long-term clinical outcome is expected.
authors.affiliation: Division of Radiation Oncology, Department of Radiology, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand. wisutiyano@yahoo.com
authors.forename: Chawalit
authors.initials: C
authors.lastname: Lertbutsayanukul
authors.forename: Chonlakiet
authors.initials: C
authors.lastname: Khorprasert
authors.forename: Kanjana
authors.initials: K
authors.lastname: Shotelersuk
authors.forename: Chotika
authors.initials: C
authors.lastname: Jumpangern
authors.forename: Taweap
authors.initials: T
authors.lastname: Sanghangthum
authors.forename: Sornjarod
authors.initials: S
authors.lastname: Oonsiri
authors.forename: Isra Israngkul Na
authors.initials: II
authors.lastname: Ayuthaya
authors.forename: Sivalee
authors.initials: S
authors.lastname: Suriyapee
authors.forename: Winai
authors.initials: W
authors.lastname: Wadwongtham
authors.forename: Siripornchai
authors.initials: S
authors.lastname: Supanakorn
authors.forename: Virachai
authors.initials: V
authors.lastname: Kerekanjanarong
authors.forename: Prayuth
authors.initials: P
authors.lastname: Rojpornpradit
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use; D003131:Combined Modality Therapy; D005260:Female; D006258:Head and Neck Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000532:radiotherapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D050397:Radiotherapy, Intensity-Modulated; D012189:Retrospective Studies; D015996:Survival Rate; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents