title: [Bacteriological and pathological analysis on the pathogenetic factors for cavitary and nodular bronchiectatic type of pulmonary Mycobacterium avium-intracellulare complex disease].
abstract: A total of 101 strains of Mycobacterium avium complex (MAC), consisting of 86 M. avium and 15 M. intracellulare strains, were examined by DNA sequencing. The frequency of radiological types [cavitary (Cav) type and nodular bronchiectatic (NB) type] was similar in each species, thus, both species are equal causes of the two radiological types of MAC disease. We also examined serovars of the isolated strains using extracted glycopeptidelipid antigens and thin layer chromatography. Cav type patients discharged a single serovar MAC, while NB type patients discharged two serovar MACs simultaneously. RFLP pattern obtained by the use of IS1245, revealed no clustering of the strains specific for Cav type and NB type. Histopathological examinations of the bronchial lesions in 40 MAC cases and 49 multi-drug resistant tuberculosis (MDR-TB) cases were performed on the surgically removed lung specimens. Lymphocytic infiltration, epithelioid cell granuloma formation, epithelial desquamation and ulceration, as well as smooth muscle atrophy as a cause of bronchiolectasis, were observed more often and were more severe in the peripheral bronchial walls of the NB type than the Cav type of MAC, and as compared with those of MDR-TB cases.
authors.affiliation: Department of Respiratory Medicine, Fukujuji Hospital, Japan Anti-Tuberculosis Association.
authors.forename: Masao
authors.initials: M
authors.lastname: Okumura
authors.forename: Kazuro
authors.initials: K
authors.lastname: Iwai
authors.forename: Ikuya
authors.initials: I
authors.lastname: Yano
authors.forename: Mituyoshi
authors.initials: M
authors.lastname: Takahashi
authors.forename: Yuko
authors.initials: Y
authors.lastname: Kasumi
authors.forename: Sayuri
authors.initials: S
authors.lastname: Tanaka
authors.forename: Takashi
authors.initials: T
authors.lastname: Yoshiyama
authors.forename: Hideo
authors.initials: H
authors.lastname: Ogata
authors.forename: Yutuki
authors.initials: Y
authors.lastname: Nakajima
authors.forename: Arata
authors.initials: A
authors.lastname: Azuma
authors.forename: Shouji
authors.initials: S
authors.lastname: Kudoh
mesh_terms: D003937:Diagnosis, Differential; D006801:Humans; D015269:Mycobacterium avium Complex / Q000145:classification / Q000235:genetics; D015270:Mycobacterium avium-intracellulare Infection / Q000209:etiology* / Q000382:microbiology* / Q000473:pathology; D012150:Polymorphism, Restriction Fragment Length; D012703:Serotyping; D018088:Tuberculosis, Multidrug-Resistant; D014397:Tuberculosis, Pulmonary / Q000209:etiology* / Q000382:microbiology* / Q000473:pathology