title: Etoricoxib tolerability in patients with hypersensitivity to nonsteroidal anti-inflammatory drugs.
abstract: BACKGROUND
  Adverse reactions to nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly observed, particularly among patients with chronic urticaria or asthma. The identification of a safe and reliable alternative is a frequent problem in clinical practice. Our aim was to investigate the clinical tolerability of etoricoxib, a new selective cyclooxygenase-2 inhibitor, in a group of patients with well-established NSAID hypersensitivity.
  
  
  METHODS
  We assessed 31 adults (21 women and 10 men) who reported one or more adverse reactions to NSAIDs, manifested as cutaneous, respiratory or anaphylactic symptoms. Sixteen of them reported reactions to a single NSAID (single reactors) and 15 to more than one NSAID (multiple reactors); the most frequently involved drug was acetylsalicylic acid. First, each patient underwent allergologic tests (skin and/or oral challenge tests) with culprit NSAIDs and then tolerability tests with increasing doses of etoricoxib up to 120 mg. All challenges were performed under single-blind, placebo-controlled conditions.
  
  
  RESULTS
  NSAID hypersensitivity was diagnosed in all 31 patients: 3 displayed positive results to pyrazolone skin tests and the other 28 to challenges with culprit NSAIDs. None reacted to either placebos or etoricoxib.
  
  
  CONCLUSIONS
  Etoricoxib seems to be a safe alternative for patients with well-demonstrated NSAID hypersensitivity.
authors.affiliation: Department of Internal Medicine and Geriatrics, UCSC-Allergy Unit, Complesso Integrato Columbus, Rome, Italy.
authors.forename: Marinella
authors.initials: M
authors.lastname: Viola
authors.forename: Donato
authors.initials: D
authors.lastname: Quaratino
authors.forename: Francesco
authors.initials: F
authors.lastname: Gaeta
authors.forename: Cristiano
authors.initials: C
authors.lastname: Caruso
authors.forename: Rocco
authors.initials: R
authors.lastname: Valluzzi
authors.forename: Antonino
authors.initials: A
authors.lastname: Romano
mesh_terms: D000328:Adult; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects; D016861:Cyclooxygenase Inhibitors / Q000276:immunology*; D000077613:Etoricoxib; D005260:Female; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000139:chemically induced*; D008297:Male; D008875:Middle Aged; D011725:Pyridines / Q000276:immunology*; D012882:Skin Tests; D013450:Sulfones / Q000276:immunology*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D016861:Cyclooxygenase Inhibitors; D011725:Pyridines; D013450:Sulfones; D000077613:Etoricoxib