title: The effect of oxide thickness on osteoblast attachment and survival on NiTi alloy.
abstract: NiTi alloy is used in various medical applications and the surface titanium oxide layer produced naturally or enhanced artificially has been thought to offer a protecting film against allergic and toxic effects of nickel (Ni). In this study, we investigated the effect of different oxide layer thicknesses on the survival and attachment of osteoblastic cells (ROS-17/2.8). AFM, X-ray diffraction and electrical resistance measurements were used to analyze the surface properties of oxidized NiTi samples and the effect of oxidation on material properties. The results clearly showed that straight correlation between oxide thickness and cellular well-being cannot be maid. However, the different thicknesses of oxide layer on NiTi had surprising impacts on cellular responses and also to the properties of the metal alloy.
authors.affiliation: Department of Anatomy and Cell Biology, University of Oulu, Oulu, Finland.
authors.forename: V
authors.initials: V
authors.lastname: Muhonen
authors.forename: R
authors.initials: R
authors.lastname: Heikkinen
authors.forename: A
authors.initials: A
authors.lastname: Danilov
authors.forename: T
authors.initials: T
authors.lastname: Jämsä
authors.forename: J
authors.initials: J
authors.lastname: Tuukkanen
mesh_terms: D000497:Alloys / Q000737:chemistry / Q000633:toxicity; D000818:Animals; D002448:Cell Adhesion / Q000187:drug effects; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D020099:Coated Materials, Biocompatible / Q000737:chemistry* / Q000633:toxicity; D017097:Electric Impedance; D022001:Focal Adhesions / Q000187:drug effects; D008422:Materials Testing; D009532:Nickel / Q000737:chemistry* / Q000633:toxicity; D010006:Osteoblasts / Q000166:cytology* / Q000187:drug effects; D051381:Rats; D013499:Surface Properties; D014025:Titanium / Q000737:chemistry* / Q000633:toxicity; D014961:X-Ray Diffraction
chemical_list: D000497:Alloys; D020099:Coated Materials, Biocompatible; C040654:titanium nickelide; C009495:titanium dioxide; D009532:Nickel; D014025:Titanium