HeLa cells apoptosis induced by 1,7-dimethyl-1,4,7,10-tetraazacyclododecane.
Preliminary pharmacological tests showed that 1,7-dimethyl-1,4,7,10-tetraazacyclododecane (DMC) had antitumor activity against HeLa and A549 cell lines in vitro. The HeLa cells apoptosis induced by DMC was examined by flow cytometric meter, and further confirmed by observing the morphological changes and DNA fragmentation. No observation of A549 cells induced apoptosis was observed by DMC.
Yang
Li
L
College of Chemistry and Molecular Sciences, Wuhan University, Hubei, Wuhan 430072, PR China. chemoliangf@yahoo.com.cn
Liang
Feng
F
Liu
Min
M
Zheng
Congyi
C
Wan
Shuhui
S
Xiong
Xiaoqin
X
Zhang
Xiaolian
X
Shen
Chao
C
Zhou
Xiang
X
D017209:Apoptosis / Q000187:drug effects*; D002453:Cell Cycle / Q000187:drug effects; D045744:Cell Line, Tumor; D053938:DNA Fragmentation / Q000187:drug effects; D004273:DNA, Neoplasm / Q000187:drug effects; D005434:Flow Cytometry; D006367:HeLa Cells; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*; D006801:Humans
C512308:1,7-dimethyl-1,4,7,10-tetraazacyclododecane; D004273:DNA, Neoplasm; D006571:Heterocyclic Compounds