Delayed release particles from vascular endothelial growth factor for repairing spinal cord ischemic injury of rats.
OBJECTIVE
To study the effect of delayed release particles from vascular endothelial growth factor (VEGF) on the reparation of ischemic injury of spinal cord in rats.


METHODS
The spinal cord ischemia model of rats was established. The delayed release particles from VEGF were injected via the intubation of spinal subarachnoid space. The rehabilitation was observed by the assessment of unfold claw reflection, space between toes, spinal evoked potential (SEP) and motor evoked potential (MEP).


RESULTS
VEGF prompted SEP and MEP appearance, improved the motor function of hind limbs.


CONCLUSIONS
VEGF can promote the rehabilitation of spinal cord ischemic injury of rats.
Chen
Yang
Y
Department of Orthopaedics, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, and Shenzhen Second People's Hospital, Shenzhen Guangdong, China. chyang@public.szonline.net
Li
Feng
F
Xiao
Jian-de
JD
Li
Zhen-yu
ZY
Yang
Lei
L
Luo
Xin-le
XL
D000818:Animals; D003692:Delayed-Action Preparations; D008833:Microcirculation / Q000187:drug effects; D023421:Models, Animal; D018919:Neovascularization, Physiologic / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D013119:Spinal Cord Injuries / Q000534:rehabilitation / Q000628:therapy*; D020760:Spinal Cord Ischemia / Q000628:therapy*; D042442:Vascular Endothelial Growth Factors / Q000008:administration & dosage / Q000627:therapeutic use*
D003692:Delayed-Action Preparations; D042442:Vascular Endothelial Growth Factors