title: High-level telithromycin resistance in a clinical isolate of Streptococcus pneumoniae.
abstract: A rare clinical isolate of Streptococcus pneumoniae, highly resistant to telithromycin, contained erm(B) with a truncated leader peptide and a mutant ribosomal protein L4. By transformation of susceptible strains, this study shows that high-level telithromycin resistance is conferred by erm(B), wild type or mutant, in combination with a (69)GTG(71)-to-TPS mutation in ribosomal protein L4.
authors.affiliation: Respiratory and Meningeal Pathogens Research Unit, National Institute for Communicable Diseases, Medical Research Council and University of the Witwatersrand, Johannesburg, South Africa. nicolew@nicd.ac.za
authors.forename: Nicole
authors.initials: N
authors.lastname: Wolter
authors.forename: Anthony M
authors.initials: AM
authors.lastname: Smith
authors.forename: Donald E
authors.initials: DE
authors.lastname: Low
authors.forename: Keith P
authors.initials: KP
authors.lastname: Klugman
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000235:genetics; D003470:Culture Media; D024881:Drug Resistance, Bacterial / Q000187:drug effects; D005838:Genotype; D006801:Humans; D048628:Ketolides / Q000494:pharmacology*; D008780:Methyltransferases / Q000235:genetics; D008826:Microbial Sensitivity Tests; D009154:Mutation / Q000235:genetics; D010641:Phenotype; D011008:Pneumococcal Infections / Q000382:microbiology*; D012269:Ribosomal Proteins / Q000235:genetics; D013296:Streptococcus pneumoniae / Q000187:drug effects* / Q000235:genetics*
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D003470:Culture Media; D048628:Ketolides; D012269:Ribosomal Proteins; C056368:ribosomal protein L4; D008780:Methyltransferases; C431709:ErmA protein, Bacteria; C106791:telithromycin