title: Delayed release particles from vascular endothelial growth factor for repairing spinal cord ischemic injury of rats.
abstract: OBJECTIVE
  To study the effect of delayed release particles from vascular endothelial growth factor (VEGF) on the reparation of ischemic injury of spinal cord in rats.
  
  
  METHODS
  The spinal cord ischemia model of rats was established. The delayed release particles from VEGF were injected via the intubation of spinal subarachnoid space. The rehabilitation was observed by the assessment of unfold claw reflection, space between toes, spinal evoked potential (SEP) and motor evoked potential (MEP).
  
  
  RESULTS
  VEGF prompted SEP and MEP appearance, improved the motor function of hind limbs.
  
  
  CONCLUSIONS
  VEGF can promote the rehabilitation of spinal cord ischemic injury of rats.
authors.affiliation: Department of Orthopaedics, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, and Shenzhen Second People's Hospital, Shenzhen Guangdong, China. chyang@public.szonline.net
authors.forename: Yang
authors.initials: Y
authors.lastname: Chen
authors.forename: Feng
authors.initials: F
authors.lastname: Li
authors.forename: Jian-de
authors.initials: JD
authors.lastname: Xiao
authors.forename: Zhen-yu
authors.initials: ZY
authors.lastname: Li
authors.forename: Lei
authors.initials: L
authors.lastname: Yang
authors.forename: Xin-le
authors.initials: XL
authors.lastname: Luo
mesh_terms: D000818:Animals; D003692:Delayed-Action Preparations; D008833:Microcirculation / Q000187:drug effects; D023421:Models, Animal; D018919:Neovascularization, Physiologic / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D013119:Spinal Cord Injuries / Q000534:rehabilitation / Q000628:therapy*; D020760:Spinal Cord Ischemia / Q000628:therapy*; D042442:Vascular Endothelial Growth Factors / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D003692:Delayed-Action Preparations; D042442:Vascular Endothelial Growth Factors