title: Variation in left atrial transmural wall thickness at sites commonly targeted for ablation of atrial fibrillation.
abstract: BACKGROUND
  The number of catheter ablations performed for atrial fibrillation (AF) has increased dramatically over the past several years. Regional variation in left atrial (LA) wall thickness is known to exist but have not been described in detail. AF ablation success and complication rates may be related to regional differences in LA wall thickness.
  
  
  OBJECTIVE
  To evaluate differences in transmural wall thickness in five pre-defined anatomic areas within the LA which are commonly targeted for AF ablation.
  
  
  METHODS
  We measured LA wall transmural thickness in 34 human heart specimens using calipers in five anatomic areas frequently targeted during AF ablation (anterior wall, septum, mitral isthmus, posterior wall and roof).
  
  
  RESULTS
  The autopsied individuals were 53% female, 67.7% had CAD, 14.7% had atrial fibrillation, 61.8% had hypertension, and 21.6% had congestive heart failure. The roof was the thinnest region with mean thickness measuring significantly less than each other area (p 0.005 for the posterior wall and <0.001 for all other areas). The septum was the thickest region with mean thickness measuring significantly greater than each other area (p = 0.05, 0.001, <0.001, <0.001 measured against the anterior wall, isthmus, posterior wall and roof, respectively).
  
  
  CONCLUSIONS
  Significant regional differences exist for mean left atrial wall thickness among the different anatomic areas within the left atrium which are often targeted during catheter ablation of AF. These differences may have significant implications in determining the ideal intensity and total duration of radiofrequency energy required to achieve a safe and successful ablation.
authors.affiliation: Electrophysiology Division, Cardiology Unit, Department of Medicine, University of Rochester Medical Center, Rochester, NY 14642-8653, USA.
authors.forename: Burr
authors.initials: B
authors.lastname: Hall
authors.forename: Vinodh
authors.initials: V
authors.lastname: Jeevanantham
authors.forename: Rochelle
authors.initials: R
authors.lastname: Simon
authors.forename: John
authors.initials: J
authors.lastname: Filippone
authors.forename: Gabriel
authors.initials: G
authors.lastname: Vorobiof
authors.forename: James
authors.initials: J
authors.lastname: Daubert
mesh_terms: D000328:Adult; D001281:Atrial Fibrillation / Q000473:pathology / Q000601:surgery*; D017115:Catheter Ablation; D005260:Female; D006325:Heart Atria / Q000473:pathology*; D006801:Humans; D008297:Male