title: Deterioration in quality of life and depressive symptoms during radiation therapy for head and neck cancer.
abstract: OBJECTIVE
  The aim of this study was to assess the quality of life and psychologic profile during radiation therapy for head and neck cancer.
  
  
  METHODS
  The University of Washington QoL instrument and the Hospital Anxiety and Depression Scale were administered to 202 patients at two or three time points during radiation therapy.
  
  
  RESULTS
  A total of 118 (54.6%) patients completed the questionnaires at the beginning and at the end of the study. A mid-treatment dataset was also available for 67 (31.0%) patients. There was a statistically significant deterioration in composite QoL scores (P < 0.000) and a statistically significant increase in depression (P < 0.000). There was no difference in anxiety levels (P = 0.276).
  
  
  CONCLUSIONS
  Patients undergoing radiation are increasingly depressed as treatment progresses, with worsening QoL during the treatment.
  
  
  CONCLUSIONS
  This study underlines the need for good psychologic support during radiation therapy in head and neck cancer.
authors.affiliation: Northern Centre for Cancer Treatment, Newcastle upon Tyne, UK.
authors.forename: Charles
authors.initials: C
authors.lastname: Kelly
authors.forename: Vinidh
authors.initials: V
authors.lastname: Paleri
authors.forename: Carole
authors.initials: C
authors.lastname: Downs
authors.forename: Raina
authors.initials: R
authors.lastname: Shah
mesh_terms: D001007:Anxiety / Q000453:epidemiology; D002294:Carcinoma, Squamous Cell / Q000523:psychology* / Q000532:radiotherapy*; D015897:Comorbidity; D003863:Depression / Q000453:epidemiology; D005260:Female; D006258:Head and Neck Neoplasms / Q000523:psychology* / Q000532:radiotherapy*; D006305:Health Status Indicators; D006801:Humans; D008297:Male; D011788:Quality of Life; D011879:Radiotherapy Dosage; D011795:Surveys and Questionnaires