title: Bactericidal activity of daptomycin, vancomycin, teicoplanin and linezolid against Staphylococcus aureus, Enterococcus faecalis and Enterococcus faecium using human peak free serum drug concentrations.
abstract: The bactericidal activities of daptomycin, vancomycin, teicoplanin and linezolid at human peak free serum concentrations (C(max,free)) were determined against Staphylococcus aureus (one methicillin-susceptible and two methicillin-resistant strains), Enterococcus faecalis and Enterococcus faecium (one vancomycin-susceptible and one vancomycin-resistant strain of each). Daptomycin was rapidly bactericidal against 7/7 strains at C(max,free) of 22.0 mg/L (corresponding to 63% protein binding) and against 3/7 strains at 4.8 mg/L (corresponding to 92% protein binding). Vancomycin (18.0 mg/L) was bactericidal against only two strains. Both teicoplanin (4.5 mg/L) and linezolid (10.4 mg/L) were consistently bacteriostatic. Daptomycin is a useful option for the treatment of Gram-positive infections owing to its strong bactericidal activity.
authors.affiliation: Antiinfectives Intelligence GmbH, Von-Liebig-Strasse 20, 53359 Rheinbach, Germany. johannes.brauers@antiinfectives-intelligence.de
authors.forename: J
authors.initials: J
authors.lastname: Brauers
authors.forename: M
authors.initials: M
authors.lastname: Kresken
authors.forename: A
authors.initials: A
authors.lastname: Menke
authors.forename: A
authors.initials: A
authors.lastname: Orland
authors.forename: H
authors.initials: H
authors.lastname: Weiher
authors.forename: I
authors.initials: I
authors.lastname: Morrissey
mesh_terms: D000081:Acetamides / Q000008:administration & dosage / Q000097:blood; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000097:blood; D017576:Daptomycin / Q000008:administration & dosage / Q000097:blood; D013293:Enterococcus faecalis / Q000187:drug effects*; D016984:Enterococcus faecium / Q000187:drug effects*; D016908:Gram-Positive Bacterial Infections / Q000097:blood / Q000188:drug therapy / Q000382:microbiology; D006801:Humans; D066298:In Vitro Techniques; D000069349:Linezolid; D008826:Microbial Sensitivity Tests; D023303:Oxazolidinones / Q000008:administration & dosage / Q000097:blood; D013211:Staphylococcus aureus / Q000187:drug effects*; D017334:Teicoplanin / Q000008:administration & dosage / Q000097:blood; D014640:Vancomycin / Q000008:administration & dosage / Q000097:blood
chemical_list: D000081:Acetamides; D000900:Anti-Bacterial Agents; D023303:Oxazolidinones; D017334:Teicoplanin; D014640:Vancomycin; D000069349:Linezolid; D017576:Daptomycin