A neural protection racket: AMPK and the GABA(B) receptor.
The cellular energy-sensing kinase AMPK is known to be activated in neurons in response to metabolic insults, but the downstream consequences have been unclear. A study by Kuramoto and colleagues in this issue of Neuron favors the idea that AMPK activation is neuroprotective, and suggests a potential mechanism for this effect involving phosphorylation of the GABA(B) receptor.
Hardie
D Grahame
DG
Division of Molecular Physiology, College of Life Sciences, University of Dundee, Dundee, Scotland, UK. d.g.hardie@dundee.ac.uk
Frenguelli
Bruno G
BG
D055372:AMP-Activated Protein Kinases; D000818:Animals; D019610:Cytoprotection / Q000502:physiology*; D004789:Enzyme Activation / Q000502:physiology; D009097:Multienzyme Complexes / Q000378:metabolism*; D009474:Neurons / Q000201:enzymology / Q000378:metabolism*; D010766:Phosphorylation; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D018080:Receptors, GABA-B / Q000378:metabolism*
D009097:Multienzyme Complexes; D018080:Receptors, GABA-B; D017346:Protein Serine-Threonine Kinases; D055372:AMP-Activated Protein Kinases