title: Autoimmune hemolytic anemia in childhood: serologic features in 100 cases.
abstract: BACKGROUND
  Red blood cell (RBC) autoimmunization is a relatively uncommon cause of anemia in children and presents some differences from those of adults. Due to its frequency, autoimmune hemolytic anemia (AIHA) in childhood has prompted very few studies, and the literature consists mostly of sporadic case histories. The objective of this study was to stress the importance of an appropriate serologic diagnosis in suspected cases.
  
  
  METHODS
  This report describes the immunohematologic features of 100 patients with AIHA studied in the Immunohaematologic Unit of Blood Bank, "La Sapienza" University of Rome. The patients were diagnosed in the same department from 1983 to 2003.
  
  
  RESULTS
  The peak incidence of AIHA was in the first 4 years of life. No sex predominance was noted. Warm AIHA was the most common type of acquired immune hemolytic anemia; it comprised 64 of the 100 patients, whereas 26 patients showed a cold AIHA. Associated AIHA showed a slightly more frequent incidence (54/100) compared to idiopathic forms of AIHA (46/100).
  
  
  CONCLUSIONS
  In this study serologic records of 100 children with confirmed AIHA are reported. This series, much larger than any previously reported, is critically reviewed and analyzed to delineate the immunologic features of the disease in childhood.
authors.affiliation: Blood Bank, "La Sapienza" University-II Faculty of Medicine, Rome, Italy. stefvaglio15@libero.it
authors.forename: Stefania
authors.initials: S
authors.lastname: Vaglio
authors.forename: Maria Cristina
authors.initials: MC
authors.lastname: Arista
authors.forename: Maria Paola
authors.initials: MP
authors.lastname: Perrone
authors.forename: Gabriella
authors.initials: G
authors.lastname: Tomei
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: Testi
authors.forename: Serelina
authors.initials: S
authors.lastname: Coluzzi
authors.forename: Gabriella
authors.initials: G
authors.lastname: Girelli
mesh_terms: D000293:Adolescent; D017677:Age Distribution; D000744:Anemia, Hemolytic, Autoimmune / Q000453:epidemiology / Q000276:immunology*; D001323:Autoantibodies / Q000097:blood; D002648:Child; D002675:Child, Preschool; D003298:Coombs Test; D004912:Erythrocytes / Q000378:metabolism; D006457:Hemoglobinuria, Paroxysmal / Q000276:immunology; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood / Q000276:immunology; D007074:Immunoglobulin G / Q000097:blood / Q000276:immunology; D015994:Incidence; D007223:Infant; D007518:Isoantibodies / Q000097:blood; D007558:Italy / Q000453:epidemiology; D012189:Retrospective Studies
chemical_list: D001323:Autoantibodies; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007518:Isoantibodies