Investigation of triboelectric charging in dry powder inhalers using electrical low pressure impactor (ELPI).
Electrostatics and triboelectrification phenomena in dry powder inhalers (DPI) are not well understood, but as shown in this study they may play an important role. Using model formulations of albuterol in lactose, the extent of triboelectrification in the operation of DPI was investigated using an electrical low pressure impactor (ELPI). An experimental apparatus was developed, the performance of the ELPI was evaluated for consistency and reproducibility, and compared to a conventional inertial impactor. Using a statistical experimental design the effects of lactose type, drug load, capsule fill, capsule material, and inhaler were assessed. DPI formulations appear to be subject to strong triboelectric effects. Charge separation can occur between different size fractions, i.e. different fractions can carry charges of different sign. In particular, lactose type, inhaler, and capsule material have a strong effect on the magnitude and polarity of the charge developed during DPI operation. The study suggests that the polarity of the aerosol can be controlled by choice of lactose type, capsule material, and inhaler, which could be exploited for targeting different lung physiologies.
Telko
Martin J
MJ
Division of Molecular Pharmaceutics, School of Pharmacy, CB 7360, The University of North Carolina, Chapel Hill, NC 27599, USA.
Kujanpää
Jukka
J
Hickey
Anthony J
AJ
D000318:Adrenergic beta-Agonists / Q000737:chemistry*; D000336:Aerosols / Q000737:chemistry; D000420:Albuterol / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D016503:Drug Delivery Systems; D005079:Excipients / Q000737:chemistry; D007785:Lactose / Q000737:chemistry; D015233:Models, Statistical; D009330:Nebulizers and Vaporizers; D010316:Particle Size; D011208:Powders / Q000737:chemistry; D015203:Reproducibility of Results; D055672:Static Electricity
D000318:Adrenergic beta-Agonists; D000336:Aerosols; D005079:Excipients; D011208:Powders; D007785:Lactose; D000420:Albuterol