Active sugar transport in health and disease.
Secondary active glucose transport occurs by at least four members of the SLC5 gene family. This review considers the structure and function of two premier members, SGLT1 and SGLT2, and their role in intestinal glucose absorption and renal glucose reabsorption. Genetics disorders of SGLTs include Glucose-Galactose Malabsorption, and Familial Renal Glucosuria. SGLT1 plays a central role in Oral Rehydration Therapy used so effectively to treat secretory diarrhoea such as cholera. Increasing attention is being focused on SGLTs as drug targets for the therapy of diabetes.
Wright
E M
EM
Department of Physiology, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095-1751, USA. ewright@mednet.ucla.edu
Hirayama
B A
BA
Loo
D F
DF
D001693:Biological Transport, Active; D002462:Cell Membrane / Q000378:metabolism; D020895:Enterocytes / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D007408:Intestinal Absorption / Q000502:physiology; D007668:Kidney / Q000378:metabolism*; D008286:Malabsorption Syndromes / Q000378:metabolism; D011487:Protein Conformation; D051247:Sodium-Glucose Transport Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D013329:Structure-Activity Relationship
D051247:Sodium-Glucose Transport Proteins; D005947:Glucose