Hormonal profiles and biochemical indices of bone turnover in Indian women.
The study establishes Indian referent database for bone turnover markers. The levels of markers decreased across the four quartiles of BMD showing a negative correlation with BMD. The study depicts that levels of hormones and bone turnover makers can aid in identifying women at risk for osteoporosis.


BACKGROUND
Biochemical markers of bone turnover reflect changes in bone metabolism earlier and aid in the management of osteoporosis. Since a referent database for Indian women is lacking, the study was initiated to establish the same and suggest that hormonal profiles and markers of bone turnover can aid in identifying women at risk for osteoporosis.


METHODS
Osteocalcin (OC), bone specific alkaline phosphatase ((BSAP), C-terminal crosslinking telopeptide of type-I collagen (CTX-I), deoxypyridinoline (DPD), follicle-stimulating hormone (FSH) and estrone glucuronide (E(1)G) were measured in 365 Indian women (20-70 years) and correlated with BMD measurements by dual energy absorptiometry (DXA) using one way analysis of variance (ANOVA).


RESULTS
The mean levels of bone resorption markers; CTX-I and DPD increased significantly across the age showing a negative correlation with BMD. The increase in levels of CTX-I and DPD was significantly higher (p < 0.0001) as compared to the femoral and spinal BMD, which dropped only 30-36%. The levels of bone turnover markers and FSH decreased across the four quartiles of spinal and femoral BMD showing a negative correlation whereas E(1)G levels increased across the four quartiles.


CONCLUSIONS
The bone turnover markers were comparatively low in cohort of Indian women studied.
Desai Meena
P
P
Department of Molecular Immunodiagnostics, National Institute for Research in Reproductive Health, Parel, Mumbai, India. immunodiagnostic_nirrh@rediffmail.com
Khatkhatay
M I
MI
Bhanu Prakash
K V
KV
Savardekar
L S
LS
Shah
R S
RS
Ansari
Z
Z
D000328:Adult; D017677:Age Distribution; D000368:Aged; D000596:Amino Acids / Q000097:blood; D015415:Biomarkers / Q000097:blood*; D001842:Bone and Bones / Q000378:metabolism*; D024042:Collagen Type I / Q000097:blood; D016208:Databases, Factual; D004970:Estrone / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006728:Hormones / Q000097:blood*; D006801:Humans; D007194:India / Q000453:epidemiology; D008875:Middle Aged; D015675:Osteocalcin / Q000097:blood; D010024:Osteoporosis / Q000208:ethnology* / Q000378:metabolism*; D051757:PAX5 Transcription Factor / Q000097:blood; D010281:Parathyroid Hormone / Q000097:blood; D010455:Peptides / Q000097:blood; D011446:Prospective Studies; D012307:Risk Factors
D000596:Amino Acids; D015415:Biomarkers; D024042:Collagen Type I; D006728:Hormones; D051757:PAX5 Transcription Factor; C497281:PAX5 protein, human; D010281:Parathyroid Hormone; D010455:Peptides; C052929:collagen type I trimeric cross-linked peptide; D015675:Osteocalcin; D004970:Estrone; D005640:Follicle Stimulating Hormone; C036020:deoxypyridinoline