Transplantation's greatest challenges: advances in chronic graft-versus-host disease.
Clinical research into chronic graft-versus-host disease (GVHD) lags behind that in other areas in the field. Interest in chronic GVHD has increased significantly in recent years for various reasons, including advances in biotechnology, a perceived increase in the incidence of chronic GVHD, and decreased regimen-related mortality, resulting in a new emphasis on quality of life and absence of disability as endpoints of major significance in transplantation survivors. In this overview, we address 3 key areas related to chronic GVHD that hold the highest promise for major advances in the near future: pathobiology, response criteria, and therapy.
Shlomchik
Warren D
WD
Department of Medical Oncology, Yale University School of Medicine, New Haven, Connecticut, USA.
Lee
Stephanie J
SJ
Couriel
Daniel
D
Pavletic
Steven Z
SZ
D002908:Chronic Disease; D006086:Graft vs Host Disease / Q000276:immunology / Q000628:therapy; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D016896:Treatment Outcome