title: Ocular findings in two colonies of gray mouse lemurs (Microcebus murinus).
abstract: OBJECTIVE
  To determine the incidence and describe the characteristics of cataracts and other ocular lesions found in two colonies of gray mouse lemurs (Microcebus murinus).
  
  
  METHODS
  A total number of 218 mouse lemurs (age range: 4 months-11 years) were included in this study. All individuals were property of the Muséum National d'Histoire Naturelle (France), and were housed either in Paris (colony #1: 75 animals examined), or in Brunoy (colony #2: 143 animals).
  
  
  METHODS
  Ocular examinations were performed on all animals before and after pupil dilation, and included slit-lamp biomicroscopy and indirect ophthalmoscopy. In both colonies, a limited number of individuals were re-examined between several months and 2 years following the initial eye examinations. The eyes of five mouse lemurs with incipient or immature cataracts that died during this period were collected, and processed for routine histopathologic examination.
  
  
  RESULTS
  A high incidence of cataracts was observed in both colonies (48% in colony #1; 21% in colony #2). Cataracts were predominantly bilateral, started in the anterior and/or posterior subcapsular area, and appeared to be slowly progressive. The earliest age at which lens opacities were observed was 3.5 years, and more than 50% of mouse lemurs over 7 years of age were diagnosed with cataracts. Complete cataracts led to blindness and were occasionally associated with other ocular lesions.
  
  
  CONCLUSIONS
  We report a high incidence of acquired, slowly progressive, bilateral cataracts in two colonies of mouse lemurs (Microcebus murinus). Further studies need to be conducted to determine the cause of this disease in this species.
authors.affiliation: Section of Ophthalmology, Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104-6010, USA.
authors.forename: William A
authors.initials: WA
authors.lastname: Beltran
authors.forename: Maria
authors.initials: M
authors.lastname: Vanore
authors.forename: Florence
authors.initials: F
authors.lastname: Ollivet
authors.forename: Florence
authors.initials: F
authors.lastname: Nemoz-Bertholet
authors.forename: Fabienne
authors.initials: F
authors.lastname: Aujard
authors.forename: Bernard
authors.initials: B
authors.lastname: Clerc
authors.forename: Sabine
authors.initials: S
authors.lastname: Chahory
mesh_terms: D000818:Animals; D000836:Animals, Zoo; D002386:Cataract / Q000453:epidemiology / Q000473:pathology / Q000662:veterinary*; D005260:Female; D005602:France / Q000453:epidemiology; D015994:Incidence; D007900:Lemur; D008297:Male