title: Apolipoprotein E epsilon4 allele is associated with Parkinson disease risk in a Mexican Mestizo population.
abstract: We investigated the association between apolipoprotein E (APOE) alleles and genotypes and Parkinson disease (PD) in 229 unrelated Mexican Mestizo PD patients and 229 controls. Results showed that both APOE-epsilon4 allele and APOE epsilon4/epsilon3 genotype are associated with PD (OR = 1.736, P = 0.011; OR = 1.688, P = 0.019, respectively). Mean age at onset of PD was not associated to any APOE allele or genotype, but was significantly earlier in familial PD when compared to sporadic cases (P = 0.025).
authors.affiliation: Department of Biological Systems, Universidad Autónoma Metropolitana Xochimilco, Mexico City, Mexico.
authors.forename: Marisol
authors.initials: M
authors.lastname: López
authors.forename: Jorge
authors.initials: J
authors.lastname: Guerrero
authors.forename: Petra
authors.initials: P
authors.lastname: Yescas
authors.forename: Marie-Catherine
authors.initials: MC
authors.lastname: Boll
authors.forename: Itziar
authors.initials: I
authors.lastname: Familiar
authors.forename: Adriana
authors.initials: A
authors.lastname: Ochoa
authors.forename: Astrid
authors.initials: A
authors.lastname: Rasmussen
authors.forename: María Elisa
authors.initials: ME
authors.lastname: Alonso
mesh_terms: D017668:Age of Onset; D000368:Aged; D053327:Apolipoprotein E4 / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008800:Mexico / Q000453:epidemiology; D008875:Middle Aged; D010300:Parkinson Disease / Q000453:epidemiology* / Q000235:genetics*; D012306:Risk
chemical_list: D053327:Apolipoprotein E4