title: Bipyridyl ligands as photoactivatable mono- and bis-alkylating agents capable of DNA cross-linking.
abstract: The photoactivation of 6,6'-bis-CH2X-[2,2']bipyridinyl-5,5'-diol ligands as mono and bis-alkylating agents has been investigated, detecting transient heterocyclic quinone methides.
authors.affiliation: Dipartimento di Chimica Organica, Università di Pavia, V.le Taramelli 10, 27100 Pavia, Italy.
authors.forename: Daniela
authors.initials: D
authors.lastname: Verga
authors.forename: Sara N
authors.initials: SN
authors.lastname: Richter
authors.forename: Manlio
authors.initials: M
authors.lastname: Palumbo
authors.forename: Remo
authors.initials: R
authors.lastname: Gandolfi
authors.forename: Mauro
authors.initials: M
authors.lastname: Freccero
mesh_terms: D015082:2,2'-Dipyridyl / Q000737:chemistry; D000596:Amino Acids / Q000737:chemistry; D002625:Chemistry, Organic / Q000379:methods; D003432:Cross-Linking Reagents / Q000494:pharmacology*; D004247:DNA / Q000737:chemistry*; D004587:Electrophoresis, Agar Gel / Q000379:methods; D007700:Kinetics; D008024:Ligands; D008027:Light; D008956:Models, Chemical; D010777:Photochemistry / Q000379:methods; D012313:RNA / Q000737:chemistry; D013053:Spectrophotometry
chemical_list: D000596:Amino Acids; D003432:Cross-Linking Reagents; D008024:Ligands; D015082:2,2'-Dipyridyl; D012313:RNA; D004247:DNA