Lipopolysaccharide aggravates cerebral pathology in B10.PL-derived CD1-/-, beta2m-/-, TCRalpha-/-, and TCRdelta-/- knockout mice.
Adult B10.PL-derived immunological genes knockout mice injected with 100 microg lipopolysaccharide (LPS) showed severe hydrocephalus and meningitis. A consequence of the hydrocephalus is pineal hyperplasia, sponginess of periventricular parenchyma, gliosis and, at the last stage of hydrocephalus formation, disappearance of the ependymal layer and the Gomori-positive subependymal astrocytes. Possible mechanisms for the aggravation of cerebral pathology induced by LPS are discussed.
Sura
Piotr
P
Department of Human Developmental Biology, Collegium Medicum, Jagiellonian University, Kopernika 7, 31-034 Kraków, Poland. mbsura@cyf-kr.edu.pl
Srebro
Zbigniew
Z
Macura
Barbara
B
Majewska
Monika
M
Zajac
Katarzyna
K
Szczepanik
Marian
M
D000818:Animals; D018949:Antigens, CD1 / Q000235:genetics / Q000502:physiology*; D001921:Brain / Q000187:drug effects* / Q000473:pathology; D005260:Female; D008070:Lipopolysaccharides / Q000633:toxicity*; D051379:Mice; D018345:Mice, Knockout; D011948:Receptors, Antigen, T-Cell / Q000235:genetics / Q000502:physiology*; D001613:beta 2-Microglobulin / Q000235:genetics / Q000502:physiology*
D018949:Antigens, CD1; D008070:Lipopolysaccharides; D011948:Receptors, Antigen, T-Cell; D001613:beta 2-Microglobulin