title: Analysis of boron distribution in vivo for boron neutron capture therapy using two different boron compounds by secondary ion mass spectrometry.
abstract: The efficiency of boron neutron capture therapy (BNCT) for malignant gliomas depends on the selective and absolute accumulation of (10)B atoms in tumor tissues. Only two boron compounds, BPA and BSH, currently can be used clinically. However, the detailed distributions of these compounds have not been determined. Here we used secondary ion mass spectrometry (SIMS) to determine the histological distribution of (10)B atoms derived from the boron compounds BSH and BPA. C6 tumor-bearing rats were given 500 mg/kg of BPA or 100 mg/kg of BSH intraperitoneally; 2.5 h later, their brains were sectioned and subjected to SIMS. In the main tumor mass, BPA accumulated heterogeneously, while BSH accumulated homogeneously. In the peritumoral area, both BPA and BSH accumulated measurably. Interestingly, in this area, BSH accumulated distinctively in a diffuse manner even 800 microm distant from the interface between the main tumor and normal brain. In the contralateral brain, BPA accumulated measurably, while BSH did not. In conclusion, both BPA and BSH each have advantages and disadvantages. These compounds are considered to be essential as boron delivery agents independently for clinical BNCT. There is some rationale for the simultaneous use of both compounds in clinical BNCT for malignant gliomas.
authors.affiliation: Department of Neurosurgery, Osaka Medical College, Takatsuki, Osaka, Japan.
authors.forename: Kunio
authors.initials: K
authors.lastname: Yokoyama
authors.forename: Shin-Ichi
authors.initials: S
authors.lastname: Miyatake
authors.forename: Yoshinaga
authors.initials: Y
authors.lastname: Kajimoto
authors.forename: Shinji
authors.initials: S
authors.lastname: Kawabata
authors.forename: Atsushi
authors.initials: A
authors.lastname: Doi
authors.forename: Toshiko
authors.initials: T
authors.lastname: Yoshida
authors.forename: Motonori
authors.initials: M
authors.lastname: Okabe
authors.forename: Mitsunori
authors.initials: M
authors.lastname: Kirihata
authors.forename: Koji
authors.initials: K
authors.lastname: Ono
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Kuroiwa
mesh_terms: D000818:Animals; D001895:Boron / Q000627:therapeutic use*; D001896:Boron Compounds / Q000627:therapeutic use*; D016754:Boron Neutron Capture Therapy / Q000379:methods*; D001921:Brain / Q000378:metabolism; D001932:Brain Neoplasms / Q000532:radiotherapy*; D045744:Cell Line, Tumor; D005910:Glioma / Q000378:metabolism / Q000532:radiotherapy; D007477:Ions; D008297:Male; D013058:Mass Spectrometry; D009368:Neoplasm Transplantation; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
chemical_list: D001896:Boron Compounds; D007477:Ions; D001895:Boron