title: CD46 expression is indicative of shorter revival-free survival for ovarian cancer patients.
abstract: BACKGROUND
  The membrane cofactor protein CD46 represents a complement inhibitor, which protects autologous cells from complement - mediated cytotoxicity. CD46 may exhibit the potential to protect tumor cells from the immune responses of the host. The present study aimed to evaluate the prognostic significance of CD46 expression in ovarian cancers.
  
  
  METHODS
  The analyses were performed on 73 ovarian cancer samples. Immunohistochemical reactions were performed on paraffin sections of tumors using monoclonal antibodies directed against CD46. The immunohistochemical reactions and the clinical observations results were subjected to statistical analysis.
  
  
  RESULTS
  Expression of CD46 was demonstrated in 60% of primary laparotomy cases and in 70% secondary cytoreduction cases. Kaplan-Meier analysis showed that a significantly shorter revival-free time was linked to cases with CD46 expression at PL (p= 0.01).
  
  
  CONCLUSIONS
  Ovarian cancers manifest CD46 expression that is linked to a less favourable prognosis.
authors.affiliation: Institute of Pathology, Charité Campus Mitte, D-10117 Berlin, Germany.
authors.forename: Pawel
authors.initials: P
authors.lastname: Surowiak
authors.forename: Verena
authors.initials: V
authors.lastname: Materna
authors.forename: Adam
authors.initials: A
authors.lastname: Maciejczyk
authors.forename: Irina
authors.initials: I
authors.lastname: Kaplenko
authors.forename: Marek
authors.initials: M
authors.lastname: Spaczynski
authors.forename: Manfred
authors.initials: M
authors.lastname: Dietel
authors.forename: Hermann
authors.initials: H
authors.lastname: Lage
authors.forename: Maciej
authors.initials: M
authors.lastname: Zabel
mesh_terms: D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D051916:Membrane Cofactor Protein / Q000096:biosynthesis*; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000276:immunology*; D016612:Paraffin Embedding; D011379:Prognosis; D012189:Retrospective Studies
chemical_list: C497857:CD46 protein, human; D051916:Membrane Cofactor Protein