Analysis of boron distribution in vivo for boron neutron capture therapy using two different boron compounds by secondary ion mass spectrometry.
The efficiency of boron neutron capture therapy (BNCT) for malignant gliomas depends on the selective and absolute accumulation of (10)B atoms in tumor tissues. Only two boron compounds, BPA and BSH, currently can be used clinically. However, the detailed distributions of these compounds have not been determined. Here we used secondary ion mass spectrometry (SIMS) to determine the histological distribution of (10)B atoms derived from the boron compounds BSH and BPA. C6 tumor-bearing rats were given 500 mg/kg of BPA or 100 mg/kg of BSH intraperitoneally; 2.5 h later, their brains were sectioned and subjected to SIMS. In the main tumor mass, BPA accumulated heterogeneously, while BSH accumulated homogeneously. In the peritumoral area, both BPA and BSH accumulated measurably. Interestingly, in this area, BSH accumulated distinctively in a diffuse manner even 800 microm distant from the interface between the main tumor and normal brain. In the contralateral brain, BPA accumulated measurably, while BSH did not. In conclusion, both BPA and BSH each have advantages and disadvantages. These compounds are considered to be essential as boron delivery agents independently for clinical BNCT. There is some rationale for the simultaneous use of both compounds in clinical BNCT for malignant gliomas.
Yokoyama
Kunio
K
Department of Neurosurgery, Osaka Medical College, Takatsuki, Osaka, Japan.
Miyatake
Shin-Ichi
S
Kajimoto
Yoshinaga
Y
Kawabata
Shinji
S
Doi
Atsushi
A
Yoshida
Toshiko
T
Okabe
Motonori
M
Kirihata
Mitsunori
M
Ono
Koji
K
Kuroiwa
Toshihiko
T
D000818:Animals; D001895:Boron / Q000627:therapeutic use*; D001896:Boron Compounds / Q000627:therapeutic use*; D016754:Boron Neutron Capture Therapy / Q000379:methods*; D001921:Brain / Q000378:metabolism; D001932:Brain Neoplasms / Q000532:radiotherapy*; D045744:Cell Line, Tumor; D005910:Glioma / Q000378:metabolism / Q000532:radiotherapy; D007477:Ions; D008297:Male; D013058:Mass Spectrometry; D009368:Neoplasm Transplantation; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D001896:Boron Compounds; D007477:Ions; D001895:Boron