New insight into the mechanism of methyl transfer during the biosynthesis of fosfomycin.
Hydroxyethylphosphonate is a required intermediate in fosfomycin biosynthesis.
Woodyer
Ryan D
RD
Department of Chemistry, University of Illinois at Urbana-Champaign, 600 S Mathews Ave, Urbana, IL 61801, USA.
Li
Gongyong
G
Zhao
Huimin
H
van der Donk
Wilfred A
WA
D005578:Fosfomycin / Q000096:biosynthesis* / Q000737:chemistry*; D008745:Methylation; D008780:Methyltransferases / Q000378:metabolism; D015394:Molecular Structure; D063065:Organophosphonates / Q000737:chemistry; D048170:Streptomyces lividans / Q000737:chemistry / Q000235:genetics / Q000378:metabolism
C519566:2-hydroxyethyl phosphonate; D063065:Organophosphonates; D005578:Fosfomycin; D008780:Methyltransferases