title: [Centripetal distribution of body fat, overweight and cardiorespiratory fitness: association with insulin sensitivity and metabolic alterations].
abstract: The purpose of this paper was to investigate associations between the centripetal distribution of the body fat and serum lipid-lipoproteins, blood pressure and the index Homa-IR of insulin resistance, adjusting for indicators of overweight and cardiorespiratory fitness. Eighty-nine voluntaries were analyzed (44 men and 45 women). The centripetal distribution of the body fat was analyzed through waist circumference (CC) and the overweight by the body mass index (BMI). The cardiorespiratory fitness was followed by the estimate VO(2)max by test of walking. After adjusted for BMI values were found significant coefficient of correlation between CC and levels of blood pressure and ApoB in men, and between CC and index Homa-IR and triglycerides in women. After adjusted for VO(2)max values were verified significant correlations between CC and ApoB and index Homa-IR in men, and between CC and index Homa-IR in women. In conclusion, depending on the sex, the quantity and distribution of the body fat can present different actions in the insulin resistance and associated dysfunctions. The cardiorespiratory fitness per se seems not to contribute on the minimization of the association between the centripetal distribution of the body fat and the index Homa-IR; but presents a considerable impact on the association between the centripetal distribution of the body fat and the lipid metabolism and the levels of blood pressure, mainly in men.
authors.affiliation: Centro de Ciências Biológicas e Saúde, Universidade Norte do Paraná.
authors.forename: José Luciano T
authors.initials: JL
authors.lastname: da Silva
authors.forename: Décio Sabbatini
authors.initials: DS
authors.lastname: Barbosa
authors.forename: Jair Aparecido
authors.initials: JA
authors.lastname: de Oliveira
authors.forename: Dartagnan Pinto
authors.initials: DP
authors.lastname: Guedes
mesh_terms: D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure / Q000502:physiology; D050218:Body Fat Distribution; D015992:Body Mass Index; D002320:Cardiovascular Physiological Phenomena; D005260:Female; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D050152:Intra-Abdominal Fat / Q000502:physiology; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications / Q000378:metabolism* / Q000473:pathology; D050177:Overweight / Q000473:pathology / Q000503:physiopathology; D010101:Oxygen Consumption / Q000502:physiology; D010809:Physical Fitness / Q000502:physiology*; D012143:Respiratory Physiological Phenomena; D012307:Risk Factors; D012737:Sex Factors; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D049629:Waist-Hip Ratio
chemical_list: D001786:Blood Glucose; D008074:Lipoproteins; D014409:Tumor Necrosis Factor-alpha