Time course of axonal regeneration in acute motor axonal neuropathy.
Patients with acute motor axonal neuropathy (AMAN) generally recover well. We reviewed clinical and electrophysiologic recovery in 13 patients for up to 5 years. Twelve patients showed rapid recovery over 12 months, whereas in the remaining one the recovery was slow and incomplete at 5 years. In AMAN, axonal degeneration appears to develop predominantly in the motor nerve terminals, and only occasionally more proximally in the nerve roots. Nerve terminal degeneration-regeneration presumably provides a mechanism for good recovery.
Tamura
Noriko
N
Department of Neurology, Chiba University School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan.
Kuwabara
Satoshi
S
Misawa
Sonoko
S
Kanai
Kazuaki
K
Nakata
Miho
M
Sawai
Setsu
S
Mori
Masahiro
M
Hattori
Takamichi
T
D000293:Adolescent; D000328:Adult; D000368:Aged; D001369:Axons / Q000473:pathology; D018450:Disease Progression; D004576:Electromyography; D005260:Female; D020275:Guillain-Barre Syndrome / Q000175:diagnosis / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009046:Motor Neurons / Q000473:pathology; D009416:Nerve Regeneration; D009431:Neural Conduction; D010525:Peripheral Nerves / Q000473:pathology / Q000503:physiopathology*; D017729:Presynaptic Terminals / Q000473:pathology; D020127:Recovery of Function; D013997:Time Factors; D014855:Wallerian Degeneration / Q000209:etiology / Q000473:pathology / Q000503:physiopathology