[Effect of high sucrose- and high-fat diets ingested under free-living conditions in insulin resistance in normal weight and overweight women].
OBJECTIVE
The purpose of this study was to investigate the effect of high sucrose diet (HD) and high fat diet (RFD) ingested under free-living conditions, on insulin homeostasis, verifies the association between insulin resistance and body composition as well.


METHODS
20 healthy women, 13 normal-weight (22.5 +/- 2.1 years of age; BMI 22.2 +/- 1.9 kg/m2) and 7 over-weight (21.8 +/- 2.8 years of age; BMI 28.4 +/- 3.2 kg/m2), included in 2 groups G1 and G2 respectively, they were randomized to intake HD diets (59% carbohydrate including 23.0% of sucrose; 28.0% lipid; 13.0% protein; 20.2 g fiber) or HDF (42.0% carbohydrates including 1.3% of sucrose; 45.0% lipid; 13.0% protein; 22.2 g fiber) after initial assessment (BD). It was taken anthropometric measures, body composition and blood samples were obtained for fasting and post-prandial glucose and insulin determinations.


RESULTS
Glycemia, insulinemia and HOMA-IR did not differ between groups (p > 0.05). Although on BD, HOMA-IR correlates positively with weight (r = 0.750), BMI (r = 0.929), waist circumference (WC) (r = 0.750) and percentage body fat (r = 0.857) for G2 group. The values of fasting HOMA-IR on BD were significantly greater than HFD for G1 group (p < 0.05). On HD the total carbohydrates amount and sucrose are greater than BD and HFD.


CONCLUSIONS
The results confirm direct correlation between HOMA-IR, abdominal obesity and body fat. Therefore diet can modulate the insulinemic action.
Volp
A C Pinheiro
AC
Departamento de Nutrição e Saúde, Universidade Federal de Viçosa, Brasil. anavolp@gmail.com
Hermsdorff
Hermana Miranda
HM
Bressan
J
J
D000328:Adult; D001786:Blood Glucose / Q000032:analysis*; D004041:Dietary Fats; D019422:Dietary Sucrose; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood*; D007333:Insulin Resistance; D050177:Overweight; D011446:Prospective Studies
D001786:Blood Glucose; D004041:Dietary Fats; D019422:Dietary Sucrose; D007328:Insulin