Are statins associated with decreased tooth loss in chronic periodontitis?
OBJECTIVE
To evaluate whether statin use was associated with decreased tooth loss among patients with chronic periodontitis.


METHODS
We evaluated administrative health plan data from 1996 to 2002 covering dental and periodontal treatment utilization, dental extractions, and prescription medication fills of 12,631 adults aged 48-64 in 2002. With tooth loss as the outcome, we evaluated a number of different patterns of statin prescription across time in multivariate generalized linear models.


RESULTS
Unadjusted, statin use was associated with increased tooth loss. After adjustment for potential confounders, there was no suggestion of either increased or decreased tooth loss associated with statin use.


CONCLUSIONS
Statin use was not associated with either a decreased or an increased risk of tooth loss.
Saver
Barry G
BG
Department of Family Medicine, University of Washington, Seattle, WA, USA. barry.saver@umassmed.edu
Hujoel
Philippe P
PP
Cunha-Cruz
Joana
J
Maupomé
Gerardo
G
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D000924:Anticholesteremic Agents / Q000627:therapeutic use*; D002908:Chronic Disease; D003729:Dental Care / Q000706:statistics & numerical data; D004812:Epidemiologic Methods; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010518:Periodontitis / Q000150:complications* / Q000175:diagnosis; D012907:Smoking; D016388:Tooth Loss / Q000175:diagnosis / Q000209:etiology / Q000517:prevention & control*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000924:Anticholesteremic Agents