title: Antifungal drug susceptibility profile of Pichia anomala isolates from patients presenting with nosocomial fungemia.
abstract: In vitro susceptibility of 58 isolates of Pichia anomala to five antifungal drugs using two broth microdilution methods (CLSI and EUCAST) was analyzed. Low susceptibility to itraconazole was observed. Fluconazole, voriconazole, amphotericin B, and caspofungin showed good antifungal activity, although relatively high drug concentrations were necessary to inhibit the isolates.
authors.affiliation: Instituto Adolfo Lutz, Av Dr. Arnaldo 351, 11 andar, São Paulo, São Paulo, Brazil 01246-901. mattav@usp.br
authors.forename: Vânia Lúcia Ribeiro
authors.initials: VL
authors.lastname: da Matta
authors.forename: Márcia
authors.initials: M
authors.lastname: de Souza Carvalho Melhem
authors.forename: Arnaldo Lopes
authors.initials: AL
authors.lastname: Colombo
authors.forename: Maria Luiza
authors.initials: ML
authors.lastname: Moretti
authors.forename: Laura
authors.initials: L
authors.lastname: Rodero
authors.forename: Gisele Madeira
authors.initials: GM
authors.lastname: Duboc de Almeida
authors.forename: Marilena
authors.initials: M
authors.lastname: dos Anjos Martins
authors.forename: Silvia Figueiredo
authors.initials: SF
authors.lastname: Costa
authors.forename: Maria Beatriz G
authors.initials: MB
authors.lastname: Souza Dias
authors.forename: Márcio
authors.initials: M
authors.lastname: Nucci
authors.forename: Anna S
authors.initials: AS
authors.lastname: Levin
mesh_terms: D000666:Amphotericin B / Q000494:pharmacology; D000935:Antifungal Agents / Q000494:pharmacology*; D003428:Cross Infection / Q000382:microbiology*; D015725:Fluconazole / Q000494:pharmacology; D016469:Fungemia / Q000453:epidemiology / Q000382:microbiology*; D006801:Humans; D017964:Itraconazole / Q000494:pharmacology; D008826:Microbial Sensitivity Tests / Q000379:methods*; D010843:Pichia / Q000187:drug effects* / Q000302:isolation & purification
chemical_list: D000935:Antifungal Agents; D017964:Itraconazole; D000666:Amphotericin B; D015725:Fluconazole