Absolute configuration and antitumor activity of myxochelin A produced by Nonomuraea pusilla TP-A0861.
In the screening of antitumor compounds from microbial secondary metabolites, myxochelin A was isolated from a culture broth of Nonomuraea pusilla TP-A0861. The absolute configuration was determined to be S by synthesizing both enantiomers from an L- or D-lysine derivative and comparing their specific rotations. Both enantiomers of myxochelin A showed remarkable inhibitory effects on the invasion of murine colon 26-L5 carcinoma cells at non-cytotoxic concentrations.
Miyanaga
Satoshi
S
Department of Engineering, Toyama Prefectural University, 5180 Kurokawa, Imizu, Toyama 939-0398, Japan.
Obata
Takamasa
T
Onaka
Hiroyasu
H
Fujita
Tsuyoshi
T
Saito
Noriko
N
Sakurai
Hiroaki
H
Saiki
Ikuo
I
Furumai
Tamotsu
T
Igarashi
Yasuhiro
Y
D039903:Actinobacteria / Q000737:chemistry* / Q000378:metabolism / Q000648:ultrastructure; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D002448:Cell Adhesion / Q000187:drug effects; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000187:drug effects; D003110:Colonic Neoplasms / Q000188:drug therapy / Q000473:pathology; D008239:Lysine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D051379:Mice; D008855:Microscopy, Electron, Scanning; D019906:Nuclear Magnetic Resonance, Biomolecular; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013237:Stereoisomerism
D000970:Antineoplastic Agents; C058735:myxochelin A; D008239:Lysine