Medicinal flowers. XII.(1)) New spirostane-type steroid saponins with antidiabetogenic activity from Borassus flabellifer.
The methanolic extract from the male flowers of Borassus flabellifer was found to inhibit the increase of serum glucose levels in sucrose-loaded rats at a dose of 250 mg/kg, p.o. From the methanolic extract, six new spirostane-type steroid saponins, borassosides A-F (1-6), were isolated together with 23 known constituents. The structures of borassosides (1-6) were elucidated on the basis of chemical and physicochemical evidences. In addition, the principal steroid saponin, dioscin (13), inhibited the increase of serum glucose levels in sucrose-loaded rats at a dose of 50 mg/kg, p.o.
Yoshikawa
Masayuki
M
Kyoto Pharmaceutical University, Misasagi, Kyoto, Japan. myoshika@mb.kyoto-phu.ac.jp
Xu
Fengming
F
Morikawa
Toshio
T
Pongpiriyadacha
Yutana
Y
Nakamura
Seikou
S
Asao
Yasunobu
Y
Kumahara
Akira
A
Matsuda
Hisashi
H
D000818:Animals; D028023:Arecaceae / Q000737:chemistry*; D001786:Blood Glucose / Q000378:metabolism; D004144:Diosgenin / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D008297:Male; D000432:Methanol / Q000737:chemistry; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013997:Time Factors
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D010936:Plant Extracts; D012503:Saponins; C019357:dioscin; D004144:Diosgenin; D000432:Methanol