Retrospective analysis of the prognostic value of electroencephalography patterns obtained in pediatric in-hospital cardiac arrest survivors during three years.
OBJECTIVE
To test the hypothesis that electroencephalography has prognostic value in children after in-hospital cardiac arrest.


METHODS
Single-center, retrospective chart review.


METHODS
Urban tertiary care children's hospital, January 2001 to July 2004.


METHODS
Thirty-four consecutive children were identified from a registry of all patients resuscitated for cardiac arrest. Inclusion criteria were age >44 wks postmenstrual age to 18 yrs, survival after in-hospital cardiac arrest >24 hrs, and undergoing electroencephalography within 7 days after the cardiac arrest.


METHODS
None.


RESULTS
Prearrest, event, cardiopulmonary resuscitation, and postresuscitation variables were collected. Neurologic outcome was assessed by Pediatric Cerebral Performance Category (PCPC). Prearrest PCPC was estimated from chart review. Change in PCPC >1 or death between prearrest and time of hospital discharge was defined as poor neurologic outcome. Experts blinded to PCPC outcomes scored electroencephalographs from 1 (normal) to 5 (isoelectric). Sensitivity/specificity analysis and receiver operating characteristic curve were developed with each electroencephalography grade cutoff. Of 184 consecutive patients who had cardiac arrests in our registry, 107 survived >24 hrs, and 83 met study criteria. Thirty-four patients had electroencephalography within the first 7 days after the cardiac arrest. Among those, 16 (47%) patients had good neurologic outcome defined as no change in PCPC, and 18 (53%) died or had poor neurologic outcome. Univariate analysis showed that a higher electroencephalography score performed within 7 days was associated with poor neurologic outcome (p < .05). Positive predictive value of electroencephalography grade 4-5 for poor neurologic outcome was 90%, and negative predictive value of electroencephalography grade 1-2 for poor neurologic outcome was 91%.


CONCLUSIONS
In a single-center consecutive case series, electroencephalography background patterns during the initial 7 days after in-hospital cardiac arrest were associated with neurologic outcome in children.
Nishisaki
Akira
A
Department of Anesthesiology and Critical Care Medicine, the Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Sullivan
Joseph
J
Steger
Bernhard
B
Bayer
Carey R
CR
Dlugos
Dennis
D
Lin
Richard
R
Ichord
Rebecca
R
Helfaer
Mark A
MA
Nadkarni
Vinay
V
D016887:Cardiopulmonary Resuscitation; D002648:Child; D002675:Child, Preschool; D003627:Data Interpretation, Statistical; D004569:Electroencephalography; D005260:Female; D005500:Follow-Up Studies; D006323:Heart Arrest / Q000401:mortality / Q000628:therapy*; D006776:Hospitals, Pediatric; D006801:Humans; D007223:Infant; D008297:Male; D009460:Neurologic Examination; D011237:Predictive Value of Tests; D011379:Prognosis; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D016019:Survival Analysis; D013997:Time Factors; D016896:Treatment Outcome