UV-B irradiation attenuates dermal effects of botulinum toxin A: a randomized, double-blind, placebo-controlled study.
BACKGROUND
Botulinum toxin type A (BoNT/A) is frequently used for cosmetic indications and hyperhidrosis.


OBJECTIVE
We investigated whether UV-B irradiation alleviates the BoNT/A effect on local sudomotor activity.


METHODS
In a randomized, double-blinded trial, the anhidrotic areas after BoNT/A (100 mU) injection 48 hours before and 14 days after UV-B irradiation were compared in six healthy volunteers.


RESULTS
UV-B irradiation alleviated BoNT/A effect by approximately 30% (p=.0017). The UV-B-evoked reduction of anhidrotic areas was constant over the observation period of 14 weeks.


CONCLUSIONS
When BoNT/A is applied intradermally, excessive exposure to UV-B and sunburn should be reconsidered. The authors have indicated no significant interest with commercial supporters.
Sycha
Thomas
T
Department of Neurology, Medical University of Vienna, Vienna, Austria. thomas.sycha@meduniwien.ac.at
Kotzailias
Nicole
N
Kranz
Gottfried
G
Trautinger
Franz
F
Schnider
Peter
P
Auff
Eduard
E
D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D019274:Botulinum Toxins, Type A / Q000008:administration & dosage / Q000494:pharmacology; D004311:Double-Blind Method; D009465:Neuromuscular Agents / Q000008:administration & dosage / Q000494:pharmacology; D014466:Ultraviolet Rays / Q000009:adverse effects
D019274:Botulinum Toxins, Type A; D009465:Neuromuscular Agents