[Biological activity tests of chemical constituents from two Brazilian Labiatae plants].
We studied the bioactivities of constituents from two tropical medicinal plants, Cunila spicata and Hyptis fasciculata. These plants found in Brazil belong to the Labiatae family. Four known compounds obtained from these herbs were identified as 3alpha, 24-dihydoxylurs-12-en-28-oic acid, betulinic acid, aurantiamide acetate, and aurantiamide benzoate by spectroscopic means. 3alpha, 24-Dihydoxylurs-12-en-28-oic acid has potent inhibitory activity against Streptococcus salivarius, Streptococcus pneumoniae, Streptococcus pyogenes, and Porphyromomas gingivalis. Aurantiamide benzoate exhibited moderate inhibitory activity against xanthine oxidase. It was clarified that herbs Cunila spicata and Hyptis fasciculata are effective against bronchitis and gout.
Isobe
Takahiko
T
Department of Chemistry, Hyogo College of Medicine, Nishinomiya City, Japan. isobetkh@hyo-med.ac.jp
Doe
Matsumi
M
Morimoto
Yoshiki
Y
Nagata
Kumiko
K
Masuoka
Noriyoshi
N
Ohsaki
Ayumi
A
D001419:Bacteria / Q000187:drug effects*; D001938:Brazil; D001991:Bronchitis / Q000188:drug therapy; D004151:Dipeptides / Q000302:isolation & purification* / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D006073:Gout / Q000188:drug therapy; D019686:Lamiaceae / Q000737:chemistry*; D053978:Pentacyclic Triterpenes; D008517:Phytotherapy; D014315:Triterpenes / Q000302:isolation & purification* / Q000494:pharmacology*; D014969:Xanthine Oxidase / Q000037:antagonists & inhibitors*; D000094062:Betulinic Acid
C518792:3,24-dihydroxyurs-12-en-28-oic acid; D004151:Dipeptides; D053978:Pentacyclic Triterpenes; D014315:Triterpenes; C518793:aurantiamide benzoate; C011670:N-benzoylphenylalanylphenylalinol acetate; D014969:Xanthine Oxidase; D000094062:Betulinic Acid