title: Vaccine-based approaches to squamous cell carcinoma of the head and neck.
abstract: Vaccine-based approaches for the treatment of advanced squamous cell carcinoma of the head and neck have achieved very limited success. Improvement in vaccine efficacy for both diseases control and survival is predicated on a careful analysis of the root causes for successes and failures to date. In this review, we analyse the utility and limitations of select protective and therapeutic vaccine strategies for tumour prevention and therapy. Based on this characterisation, we define potential directions which are meritorious of future study.
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, University of Maryland School of Medicine, Baltimore, MD 21201-1619, USA.
authors.forename: X
authors.initials: X
authors.lastname: Zhang
authors.forename: J A
authors.initials: JA
authors.lastname: Moche
authors.forename: D
authors.initials: D
authors.lastname: Farber
authors.forename: S E
authors.initials: SE
authors.lastname: Strome
mesh_terms: D019496:Cancer Vaccines / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000517:prevention & control; D006258:Head and Neck Neoplasms / Q000188:drug therapy* / Q000517:prevention & control; D006801:Humans; D016219:Immunotherapy, Adoptive; D008213:Lymphocyte Activation / Q000276:immunology; D016896:Treatment Outcome
chemical_list: D019496:Cancer Vaccines