title: Chlorahololides A and B, two potent and selective blockers of the potassium channel isolated from Chloranthus holostegius.
abstract: [structure: see text] Chlorahololides A(1) and B(2), two highly complex sesquiterpenoid dimers, were isolated from Chloranthus holostegius. Their structures and absolute configurations were established by NMR spectroscopy, X-ray crystallography, and CD. Chlorahololides A (1) and B (2) exhibited potent and selective inhibition on the delayed rectifier (IK) K+ current, with an IC50 of 10.9 and 18.6 microM, respectively.
authors.affiliation: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai, 201203, PRC.
authors.forename: Sheng-Ping
authors.initials: SP
authors.lastname: Yang
authors.forename: Zhao-Bing
authors.initials: ZB
authors.lastname: Gao
authors.forename: Fang-Dao
authors.initials: FD
authors.lastname: Wang
authors.forename: Shang-Gao
authors.initials: SG
authors.lastname: Liao
authors.forename: Hua-Dong
authors.initials: HD
authors.lastname: Chen
authors.forename: Chuan-Rui
authors.initials: CR
authors.lastname: Zhang
authors.forename: Guo-Yuan
authors.initials: GY
authors.lastname: Hu
authors.forename: Jian-Min
authors.initials: JM
authors.lastname: Yue
mesh_terms: D002942:Circular Dichroism; D018360:Crystallography, X-Ray; D009682:Magnetic Resonance Spectroscopy; D019684:Magnoliopsida / Q000737:chemistry* / Q000378:metabolism; D008958:Models, Molecular; D015394:Molecular Structure; D026902:Potassium Channel Blockers / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology; D013237:Stereoisomerism
chemical_list: D026902:Potassium Channel Blockers; D012717:Sesquiterpenes; C519126:chlorahololide A; C519127:chlorahololide B