Antiviral activity of berberine and related compounds against human cytomegalovirus.
Berberine chloride (1) and the structurally related compounds were assessed for the anti-human cytomegalovirus (HCMV) activity using the plaque assay. The anti-HCMV activity (IC(50) 0.68 microM) of 1 was equivalent to that (IC(50) 0.91 microM) of ganciclovir (GCV). The mechanism of action by which 1 inhibits the replication of HCMV is presumed to be different from that of GCV; 1 would interfere with intracellular events after virus penetration into the host cells and before viral DNA synthesis.
Hayashi
Kyoko
K
Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.
Minoda
Kazuki
K
Nagaoka
Yasuo
Y
Hayashi
Toshimitsu
T
Uesato
Shinichi
S
D000998:Antiviral Agents; D001599:Berberine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D003587:Cytomegalovirus / Q000187:drug effects*; D004261:DNA Replication / Q000187:drug effects; D004279:DNA, Viral / Q000096:biosynthesis; D015774:Ganciclovir / Q000494:pharmacology; D006801:Humans; D013329:Structure-Activity Relationship; D010948:Viral Plaque Assay; D014779:Virus Replication / Q000187:drug effects
D000998:Antiviral Agents; D004279:DNA, Viral; D001599:Berberine; D015774:Ganciclovir