title: Abortion due to Salmonella enterica serovar Abortusovis (S. Abortusovis) in ewes is associated to a lack of production of IFN-gamma and can be prevented by immunization with inactivated S. Abortusovis vaccine.
abstract: Salmonellosis due to Salmonella enterica serovar Abortusovis (S. Abortusovis) is mainly characterized by abortion in sheep. Little is known about the immune response, which develops in the host as a result of infection. We evaluated the immune response of pregnant ewes vaccinated and successively exposed to full virulent S. Abortusovis. We found that vaccine constituted by inactivated S. Abortusovis induced both humoral and cellular-mediated immune response and that it provided protection against a challenge infection due to a fully virulent S. Abortusovis. Furthermore, we found an association between the lack of capability to produce IFN-gamma and abortion. This evidence suggests that protection against abortion can be associated to an IFN-gamma mediated mechanism. Our findings represent an interesting insight to better understand the interplay between host and S. Abortusovis and the effector mechanisms underpinning immune-based protection.
authors.affiliation: Istituto Zooprofilattico Sperimentale dell'Umbria e delle Marche, Perugia, Italy.
authors.forename: Monica
authors.initials: M
authors.lastname: Cagiola
authors.forename: Giulio
authors.initials: G
authors.lastname: Severi
authors.forename: Katia
authors.initials: K
authors.lastname: Forti
authors.forename: Miriam
authors.initials: M
authors.lastname: Menichelli
authors.forename: Paola
authors.initials: P
authors.lastname: Papa
authors.forename: Antonio
authors.initials: A
authors.lastname: De Giuseppe
authors.forename: Paolo
authors.initials: P
authors.lastname: Pasquali
mesh_terms: D000034:Abortion, Veterinary / Q000276:immunology / Q000382:microbiology* / Q000517:prevention & control*; D000372:Agglutination Tests / Q000662:veterinary; D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood; D004797:Enzyme-Linked Immunosorbent Assay / Q000662:veterinary; D005260:Female; D007371:Interferon-gamma / Q000096:biosynthesis / Q000172:deficiency / Q000276:immunology*; D011247:Pregnancy; D012481:Salmonella Infections, Animal / Q000276:immunology* / Q000382:microbiology / Q000517:prevention & control; D022562:Salmonella Vaccines / Q000276:immunology / Q000627:therapeutic use*; D019779:Salmonella enterica / Q000276:immunology*; D012756:Sheep; D012757:Sheep Diseases / Q000276:immunology / Q000382:microbiology* / Q000517:prevention & control; D014611:Vaccination / Q000379:methods / Q000662:veterinary*; D014613:Vaccines, Attenuated / Q000276:immunology
chemical_list: D000907:Antibodies, Bacterial; D022562:Salmonella Vaccines; D014613:Vaccines, Attenuated; D007371:Interferon-gamma