Prokineticin 2 is a target gene of proneural basic helix-loop-helix factors for olfactory bulb neurogenesis.
Prokineticin 2, a cysteine-rich secreted protein, regulates diverse biological functions including the neurogenesis of olfactory bulb. Here we show that the PK2 gene is a functional target gene of proneural basic helix-loop-helix (bHLH) factors. Neurogenin 1 and MASH1 activate PK2 transcription by binding to E-box motifs on the PK2 promoter with the same set of E-boxes critical for another pair of bHLH factors, CLOCK and BMAL1, in the regulation of circadian clock. Our results establish PK2 as a common functional target gene for different bHLH transcriptional factors in mediating their respective functions.
Zhang
Chengkang
C
Department of Pharmacology, University of California, Irvine, California 92697, USA.
Ng
Kwan L
KL
Li
Jia-Da
JD
He
Fei
F
Anderson
David J
DJ
Sun
Yi E
YE
Zhou
Qun-Yong
QY
D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins / Q000235:genetics / Q000502:physiology*; D002454:Cell Differentiation; D002465:Cell Movement; D005768:Gastrointestinal Hormones / Q000235:genetics*; D005786:Gene Expression Regulation; D051379:Mice; D009419:Nerve Tissue Proteins / Q000502:physiology; D009479:Neuropeptides / Q000235:genetics*; D009830:Olfactory Bulb / Q000502:physiology*; D011401:Promoter Regions, Genetic; D013234:Stem Cells / Q000166:cytology
D051792:Basic Helix-Loop-Helix Proteins; D005768:Gastrointestinal Hormones; D009419:Nerve Tissue Proteins; D009479:Neuropeptides; C499317:Ascl1 protein, mouse; C486586:Prok2 protein, mouse; C486336:Neurog1 protein, mouse