title: Hyperbaric oxygen for adjuvant therapy for chronically recurrent mandibular osteomyelitis in childhood and adolescence.
abstract: OBJECTIVE
  In this article, the question of whether adjuvant hyperbaric oxygen therapy (HBO) has a positive effect when treating chronically recurrent mandibular osteomyelitis in children and adolescents is discussed.
  
  
  METHODS
  Over a period of 5 years, 4 cases were observed, 3 of which were submitted to adjuvant HBO. Details on the modalities of this type of treatment and the simultaneous intravenous administration of high doses of antibiotics are reported.
  
  
  RESULTS
  All 3 patients have been free of any symptoms from 20 to 74 months (mean, 41 months) and therefore may most likely be regarded as healed.
  
  
  CONCLUSIONS
  The small number of cases does not allow a final statement on the extent to which HBO contributed to the positive outcome. However, in our opinion, HBO is a most promising therapeutic option. Finally, the problems involved in prospective randomized studies of this rare disease are discussed in detail.
authors.affiliation: Hyperbaric Oxygen Unit, Institute of Diagnostic Radiology, Institute of Diagnostic Radiology and the Clinic of Maxillofacial Plastic Surgery, Westdeutsche Kieferklinik, University Hospital Düsseldorf, Düsseldorf, Germany. lentrodt@t-online.de
authors.forename: Stefan
authors.initials: S
authors.lastname: Lentrodt
authors.forename: Jürgen
authors.initials: J
authors.lastname: Lentrodt
authors.forename: Norbert
authors.initials: N
authors.lastname: Kübler
authors.forename: Ulrich
authors.initials: U
authors.lastname: Mödder
mesh_terms: D000293:Adolescent; D002648:Child; D002908:Chronic Disease; D005260:Female; D006801:Humans; D006931:Hyperbaric Oxygenation; D008279:Magnetic Resonance Imaging; D008297:Male; D008336:Mandibular Diseases / Q000628:therapy*; D010019:Osteomyelitis / Q000628:therapy*; D016032:Randomized Controlled Trials as Topic; D055502:Secondary Prevention; D016896:Treatment Outcome