Systems biology: new paradigms for cell biology and drug design.
In this chapter various facets of and approaches to systems biology will be discussed. This then leads to an illustration of how systems biology may be used in drug target design. We present five new paradigms for drug target research and show how these are based in systems biology.
Westerhoff
H V
HV
Department of Molecular Cell Physiology, Faculty of Earth and Life Sciences, Free University, Amsterdam, The Netherlands. hans.westerhoff@falw.vu.nl
D002626:Chemistry, Pharmaceutical / Q000379:methods*; D015195:Drug Design; D004345:Drug Industry / Q000379:methods*; D048049:Extracellular Signal-Regulated MAP Kinases / Q000378:metabolism; D006801:Humans; D008962:Models, Theoretical; D009369:Neoplasms / Q000378:metabolism; D009991:Oscillometry; D010766:Phosphorylation; D012313:RNA / Q000737:chemistry; D012825:Silicon / Q000737:chemistry; D013269:Stochastic Processes; D049490:Systems Biology
D012313:RNA; D048049:Extracellular Signal-Regulated MAP Kinases; D012825:Silicon