In-vitro antibacterial, antifungal and cytotoxic activity of cobalt (II), copper (II), nickel (II) and zinc (II) complexes with furanylmethyl- and thienylmethyl-dithiolenes: [1, 3-dithiole- 2-one and 1,3-dithiole-2-thione].
Some antibacterial and antifungal furanylmethyl-and thienylmethyl dithiolenes and, their Co(II), Cu(II), Ni (II) and Zn (II) complexes have been synthesized, characterized and screened for their in vitro antibacterial activity against four Gram-negative; Escherichia coli, Pseudomonas aeruginosa, Salmonella typhi and Shigella flexeneri, and two Gram-positive; Bacillus subtilis and Staphylococcus aureus bacterial strains, and for in-vitro antifungal activity against Trichophyton longifusus, Candida albicans, Aspergillus flavus, Microsporum canis, Fusarium solani and Candida glaberata. All compounds showed significant antibacterial and antifungal activity. The metal complexes, however, were shown to possess better activity as compared to the simple ligands. The brine shrimp bioassay was also carried out to study their in-vitro cytotoxic properties.
Chohan
Zahid H
ZH
Department of Chemistry, Bahauddin Zakariya University, Multan, Pakistan. zchohan@mul.paknet.com.pk
Shaikh
Ali U
AU
Supuran
Claudiu T
CT
D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity; D000890:Anti-Infective Agents / Q000737:chemistry* / Q000494:pharmacology*; D000935:Antifungal Agents / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity; D001156:Artemia / Q000187:drug effects; D003035:Cobalt / Q000737:chemistry / Q000494:pharmacology; D003300:Copper / Q000737:chemistry / Q000494:pharmacology; D003603:Cytotoxins / Q000737:chemistry / Q000494:pharmacology; D008024:Ligands; D019216:Metals, Heavy / Q000737:chemistry* / Q000494:pharmacology*; D009532:Nickel / Q000737:chemistry / Q000494:pharmacology; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D013871:Thiones / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D014050:Toluene / Q000031:analogs & derivatives / Q000737:chemistry; D015032:Zinc / Q000737:chemistry / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000935:Antifungal Agents; D003603:Cytotoxins; D008024:Ligands; D019216:Metals, Heavy; D009942:Organometallic Compounds; D013871:Thiones; D014050:Toluene; D003035:Cobalt; D003300:Copper; D009532:Nickel; D015032:Zinc; C004848:dithiol