Bacterial infections of the cornea (Pseudomonas aeruginosa).
Pseudomonas aeruginosa is a common organism associated with bacterial keratitis, especially in extended wear contact lens users. Recent advances in the field have been made using animal models, including inbred murine models that are classed as resistant (cornea heals) versus susceptible (cornea perforates). Overall, studies with these inbred mice provide a better understanding of the mechanisms of innate immune responsiveness and abrogation of immune privilege operative after P. aeruginosa corneal infection.
Hazlett
Linda D
LD
Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, Mich., USA.
D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D054407:Chemokine CCL4; D006801:Humans; D007113:Immunity, Innate; D007371:Interferon-gamma / Q000502:physiology; D018664:Interleukin-12 / Q000502:physiology; D020382:Interleukin-18 / Q000502:physiology; D007634:Keratitis / Q000276:immunology*; D019402:Macrophage Inflammatory Proteins / Q000502:physiology; D008264:Macrophages / Q000502:physiology; D051379:Mice; D011552:Pseudomonas Infections / Q000276:immunology*; D051193:Toll-Like Receptors / Q000502:physiology
D054407:Chemokine CCL4; D020382:Interleukin-18; D019402:Macrophage Inflammatory Proteins; D051193:Toll-Like Receptors; D018664:Interleukin-12; D007371:Interferon-gamma