title: Bronchiolitis obliterans organizing pneumonia after bone marrow transplantation: association with human leukocyte antigens.
abstract: This is the first study reporting the relationship between the development of bronchiolitis obliterans organizing pneumonia (BOOP) and human leukocyte antigen (HLA) in patients with bone marrow transplantation (BMT). The HLA B35 was significantly higher in patients with BOOP than in patients without BOOP after BMT (P = 0.0069). The HLA B35 is important as a host factor for the generation of BOOP after BMT.
  
  
  OBJECTIVE
  To assess the relationship between the development of BOOP after BMT and HLA.
  
  
  METHODS
  We retrospectively reviewed clinical features and chest computed tomographic scans in 64 patients who underwent allogeneic BMT between March 1990 and September 2004, and evaluated the relationship between HLA and development of BOOP.
  
  
  RESULTS
  Development of BOOP was between days 22 and 347 (mean, 114 days). The common computed tomographic findings consisted of patchy consolidation in subpleural and/or peribronchovascular distributions. Frequency of HLA B35 in patients with BOOP development after BMT was significantly higher than in patients without BOOP after BMT (P = 0.0069). There were no significant relationships between the others of this antigen and BOOP development.
  
  
  CONCLUSIONS
  Our results suggested that HLA B35 is an important host factor for the generation of BOOP after BMT.
authors.affiliation: Department of Diagnostic and Interventional Radiology, Oita University Faculty of Medicine, Oita, Japan.
authors.forename: Sachie
authors.initials: S
authors.lastname: Yotsumoto
authors.forename: Fumito
authors.initials: F
authors.lastname: Okada
authors.forename: Shinji
authors.initials: S
authors.lastname: Yotsumoto
authors.forename: Yumiko
authors.initials: Y
authors.lastname: Ando
authors.forename: Shunro
authors.initials: S
authors.lastname: Matsumoto
authors.forename: Masaki
authors.initials: M
authors.lastname: Wakisaka
authors.forename: Hiromu
authors.initials: H
authors.lastname: Mori
authors.forename: Masao
authors.initials: M
authors.lastname: Ogata
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kikuchi
mesh_terms: D000328:Adult; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D018549:Cryptogenic Organizing Pneumonia / Q000276:immunology*; D005260:Female; D006680:HLA Antigens / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies
chemical_list: D006680:HLA Antigens