Grazing-angle fiber-optic fourier transform infrared reflection-absorption spectroscopy for the in situ detection and quantification of two active pharmaceutical ingredients on glass.
Fourier transform infrared reflection-absorption spectroscopy has been used with a fiber-optic grazing-angle reflectance probe as a rapid, in situ method for trace surface analysis of acetaminophen and aspirin at loadings of approximately 0-2 microg cm(-2) on glass. Partial least-squares multivariate regression permits the loadings to be quantified, simultaneously, with root-mean-squared errors of prediction of RMSEP approximately 0.1 microg cm(-2) for both compounds. The detection limits are estimated to be LD approximately 0.2 microg cm(-2).
Perston
Benjamin B
BB
Department of Chemistry, University of Canterbury, Christchurch, New Zealand.
Hamilton
Michelle L
ML
Williamson
Bryce E
BE
Harland
Peter W
PW
Thomson
Mary A
MA
Melling
Peter J
PJ
D000082:Acetaminophen / Q000032:analysis; D001241:Aspirin / Q000032:analysis; D005898:Glass; D015999:Multivariate Analysis; D004364:Pharmaceutical Preparations / Q000032:analysis*; D017550:Spectroscopy, Fourier Transform Infrared / Q000295:instrumentation* / Q000379:methods*
D004364:Pharmaceutical Preparations; D000082:Acetaminophen; D001241:Aspirin