title: Radiofrequency ablation therapy in patients with breast cancers two centimeters or less in size.
abstract: BACKGROUND
  Non-surgical ablation is an attractive approach as a local control method for breast cancer. The purpose of this study was to investigate the complications and efficacy of radiofrequency ablation (RFA) therapy for breast cancer.
  
  
  METHODS
  A total of 52 patients with breast cancer were enrolled. The mean tumor size was 1.3 cm (range, 0.5-2.0 cm). Under general anesthesia, RFA was done with a Cool-tip RF system after sentinel node biopsy. All patients received one session of RFA, for a maximum time of 30 minutes for the first 29 patients and 15 minutes for the following 23 patients when so-called 'break', i.e. stopping the delivery of radiofrequency, did not occur. Postoperative cytological evaluation was done 3-4 weeks after operation. Adjuvant therapy consisted of chemo- and/or endocrine-therapy and radiotherapy (50 Gy).
  
  
  RESULTS
  The mean time of RFA was 12 minutes (5-25 minutes). One patient (2%) was troubled with a skin burn just above the ablated field. No patient had viable cancer cells on post-operative cytological evaluation. No recurrence developed 15 months on the average after RFA (6-30 months). Cosmesis after RFA was excellent in 43 patients (83%), good in 6 (12%), and fair in 3 (6%).
  
  
  CONCLUSIONS
  RFA can be safely used for breast cancer and provides good local control and excellent cosmesis to patients with small breast cancers.
authors.affiliation: Department of Thoracic and Cardiovascular Surgery, Wakayama Medical University, Wakayama, Japan. soura@wakayama-med.ac.jp
authors.forename: Shoji
authors.initials: S
authors.lastname: Oura
authors.forename: Takeshi
authors.initials: T
authors.lastname: Tamaki
authors.forename: Issei
authors.initials: I
authors.lastname: Hirai
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Yoshimasu
authors.forename: Fuminori
authors.initials: F
authors.lastname: Ohta
authors.forename: Rie
authors.initials: R
authors.lastname: Nakamura
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Okamura
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000473:pathology* / Q000601:surgery*; D002277:Carcinoma / Q000473:pathology* / Q000601:surgery*; D017115:Catheter Ablation; D004954:Esthetics; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D021701:Sentinel Lymph Node Biopsy