Monoclonal antibodies as therapeutic agents in oncology and antibody gene therapy.
Antibodies as therapeutic agents are mostly used in oncology, as illustrated by their applications in lymphoma, breast cancer or colorectal cancer. This review provides a brief historical sketch of the development of monoclonal antibodies for cancer treatment and summarizes the most significant clinical data for the best-established reagents to date. It also discusses strategies to improve the anti-tumor efficacy of antibody therapy, including antibody gene therapy and exploitation of bone marrow derived primary mesenchymal stem cells as the antibody gene transporter.
Zhang
Qi
Q
Transplantation Research Institute of Sun Yat-sen University, The Third Affiliated Hospital of Sun Yat-Sen University, 600 Tianhe Rd, Guangzhou 510630, China.
Chen
Guihua
G
Liu
Xinyuan
X
Qian
Qijun
Q
D000818:Animals; D000911:Antibodies, Monoclonal / Q000235:genetics / Q000627:therapeutic use*; D015316:Genetic Therapy; D006801:Humans; D009369:Neoplasms / Q000276:immunology* / Q000628:therapy*
D000911:Antibodies, Monoclonal