Fungal genetics, genomics, and secondary metabolites in pharmaceutical sciences.
Filamentous fungi produce a plethora of bioactive natural products. These metabolites display a broad range of useful activities for pharmaceutical purposes, exemplified best by the antibiotic penicillin. Yet, many more have been isolated, characterised, and tested, and some have made their way in clinical trials and into pharmaceutical practice. Through genomics, we become increasingly aware that the biosynthetic abilities for natural products are much richer than expected. The first part of our review highlights selected metabolites that filamentous fungi offer to pharmacists for drug development. This is followed by a summary on the potential of fungal genetics and genomics for pharmaceutical sciences and natural product research.
Misiek
Mathias
M
Institute for Pharmaceutical Sciences, Pharmaceutical Biology and Biotechnology, Albert-Ludwigs-University Freiburg, Germany.
Hoffmeister
Dirk
D
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification; D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification; D005658:Fungi / Q000737:chemistry* / Q000235:genetics* / Q000378:metabolism; D005800:Genes, Fungal; D016681:Genome, Fungal; D023281:Genomics; D005810:Multigene Family
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D000970:Antineoplastic Agents; D000998:Antiviral Agents