title: Depressive symptoms associated with hereditary Alzheimer's disease: a case description.
abstract: The authors describe a family group studied by the Centro de Biología Molecular y Biotecnología, and the Clínica de la Memoria, las Demencias y el Envejecimiento (Universidad Tecnológica de Pereira, Colombia), and evaluate the association of depressive symptoms with Alzheimer's disease (AD). This family presented a hereditary pattern for AD characterized by an early onset of dementia symptoms, a long preclinical depressive course, and, once the first symptoms of dementia appeared, a rapid progression to severe cognitive function impairment. The authors found a high prevalence of depressive symptoms in this family and propose that the symptoms could be an important risk factor for developing AD in the presence of other risk factors such as the APOE E4 allele.
authors.affiliation: Centro de Biología Molecular y Biotecnología, Universidad Tecnológica de Pereira, Facultad de Ciencias de la Salud, La Julita, Colombia. cenbiotep@utp.edu.co
authors.forename: Mónica Yicette Sánchez
authors.initials: MY
authors.lastname: Contreras
authors.forename: Paula Alejandra Osorio
authors.initials: PA
authors.lastname: Vargas
authors.forename: Lucero Rengifo
authors.initials: LR
authors.lastname: Ramos
authors.forename: Rafael Alarcón
authors.initials: RA
authors.lastname: Velandia
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000453:epidemiology / Q000235:genetics* / Q000523:psychology*; D053327:Apolipoprotein E4 / Q000235:genetics*; D003072:Cognition Disorders / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics; D003866:Depressive Disorder / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D008569:Memory Disorders / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics; D008875:Middle Aged; D009483:Neuropsychological Tests; D010375:Pedigree; D017354:Point Mutation / Q000235:genetics; D017678:Sex Distribution; D013315:Stress, Psychological / Q000175:diagnosis / Q000453:epidemiology / Q000523:psychology
chemical_list: D053327:Apolipoprotein E4