Synthesis and biological evaluation of new taxoids derived from 2-deacetoxytaxinine J.
A small library of 2-deacetoxytaxinine J (DAT-J) 1 derivatives was synthesised and tested in vitro for their reversal activity in human mammary carcinoma MDR cell line MCF7-R. One of the new taxoids showed to be active at 0.1 microM when tested in combination with paclitaxel.
Botta
Maurizio
M
Dipartimento Farmaco Chimico Tecnologico, Università degli Studi di Siena, via A. Moro, 53100 Siena, Italy. botta@unisi.it
Armaroli
Silvia
S
Castagnolo
Daniele
D
Fontana
Gabriele
G
Pera
Paula
P
Bombardelli
Ezio
E
D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis* / Q000494:pharmacology*; D001943:Breast Neoplasms / Q000188:drug therapy / Q000473:pathology; D045744:Cell Line, Tumor; D019008:Drug Resistance, Neoplasm; D005260:Female; D019450:Genes, MDR / Q000235:genetics; D006801:Humans; D007202:Indicators and Reagents; D043823:Taxoids / Q000138:chemical synthesis* / Q000494:pharmacology*
C519723:2-deacetoxytaxinine J; D000972:Antineoplastic Agents, Phytogenic; D007202:Indicators and Reagents; D043823:Taxoids