title: Hypolipidemic effect of triphala in experimentally induced hypercholesteremic rats.
abstract: Hypercholesteremia is one of the risk factors for coronary artery disease. The present study highlights the efficacy of Ayurvedic herbal formulation Triphala (Terminalia chebula, Terminalia belerica, and Emblica officinalis) on total cholesterol, Low density lipoprotein (LDL), Very low density lipoprotein (VLDL), High density lipoprotein (HDL) and free fatty acid in experimentally induced hypercholesteremic rats. Four groups of rats were employed namely control, Triphala treated, hypercholesterolemia rats (4% Cholesterol + 1% cholic acid + egg yolk) and Triphala pre-treatment in hypercholesteremic rats. Results showed significant increase in the total cholesterol, LDL, VLDL, and free fatty acid in hypercholesteremic rats were significantly reduced in Triphala treated hypercholesteremic rats. The data demonstrated that Triphala formulation was associated with hypolipidemic effects on the experimentally induced hypercholesteremic rats.
authors.affiliation: Department of Physiology, Dr. ALM. PG. Institute of Basic Medical Sciences, University of Madras, Chennai, Tamilnadu, India.
authors.forename: Selvaraj
authors.initials: S
authors.lastname: Saravanan
authors.forename: Ramasundaram
authors.initials: R
authors.lastname: Srikumar
authors.forename: Sundaramahalingam
authors.initials: S
authors.lastname: Manikandan
authors.forename: Narayanaperumal
authors.initials: N
authors.lastname: Jeya Parthasarathy
authors.forename: Rathinasamy
authors.initials: R
authors.lastname: Sheela Devi
mesh_terms: D000818:Animals; D002784:Cholesterol / Q000097:blood; D005230:Fatty Acids, Nonesterified / Q000097:blood; D006937:Hypercholesterolemia / Q000097:blood / Q000188:drug therapy*; D008075:Lipoproteins, HDL / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood; D008079:Lipoproteins, VLDL / Q000097:blood; D008297:Male; D008515:Medicine, Ayurvedic; D008517:Phytotherapy; D028321:Plant Preparations / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D029766:Terminalia
chemical_list: D005230:Fatty Acids, Nonesterified; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D008079:Lipoproteins, VLDL; D028321:Plant Preparations; D002784:Cholesterol