Identification of H-2d restricted Th epitopes in Urease B subunit of Helicobacter pylori.
CD4+ T cells play important roles in protection against Helicobacter pylori (H. pylori) infection. In order to better understand the immune responses of H. pylori infection and improve immune interventions against this pathogen, we identified the Th epitopes in UreB of H. pylori, an excellent vaccine candidate antigen. By using the RANKPEP prediction algorithm, we have identified and characterized three Th epitopes within the UreB antigen, which can be recognized by CD4+ T cells from BALB/c (H-2d) mice. They were U(546-561), U(229-244), and U(237-251). These epitopes have important value for studying the immune response of H. pylori infection and for designing effective vaccine against H. pylori.
Shi
Yun
Y
Department of Clinical Microbiology and Immunology, College of Medical Laboratory Science, The Third Military Medical University, Chongqing 400038, People's Republic of China.
Wu
Chao
C
Zhou
Wei-Ying
WY
Mao
Xu-Hu
XH
Guo
Gang
G
Zou
Quan-Ming
QM
D000595:Amino Acid Sequence; D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D016207:Cytokines / Q000235:genetics; D018984:Epitopes, T-Lymphocyte; D005260:Female; D016480:Helicobacter pylori / Q000276:immunology*; D000949:Histocompatibility Antigens Class II / Q000276:immunology*; D007114:Immunization; D008213:Lymphocyte Activation; D051379:Mice; D008807:Mice, Inbred BALB C; D008969:Molecular Sequence Data; D021122:Protein Subunits; D014510:Urease / Q000276:immunology*
D016207:Cytokines; D018984:Epitopes, T-Lymphocyte; D000949:Histocompatibility Antigens Class II; C111389:I-Ad antigen; C024138:I-E-antigen; D021122:Protein Subunits; D014510:Urease