title: Neonatal infection with G10P[11] rotavirus did not confer protection against subsequent rotavirus infection in a community cohort in Vellore, South India.
abstract: BACKGROUND
  Various observational studies have suggested that neonatal rotavirus infection confers protection against diarrhea due to subsequent rotavirus infection. We examined the incidence of rotavirus infection and diarrhea during the first 2 years of life among children infected with the G10P[11] rotavirus strain during the neonatal period and those not infected with rotavirus.
  
  
  METHODS
  Children were recruited at birth and were followed up at least twice weekly. Stool samples, collected every 2 weeks for surveillance and at each episode of diarrhea, were screened by enzyme-linked immunosorbent assay and were genotyped by polymerase chain reaction.
  
  
  RESULTS
  Among 33 children infected neonatally with G10P[11] and 300 children not infected with rotavirus, there was no significant difference in the rates of rotavirus-positive diarrhea (rate ratio [RR], 1.05 [95% confidence interval [CI], 0.61-1.79]), moderate or severe rotavirus-positive diarrhea (RR, 1.42 [95% CI, 0.73-2.78]), or asymptomatic rotavirus shedding (RR, 1.25 [95% CI, 0.85-1.83]).
  
  
  CONCLUSIONS
  Neonatal G10P[11] infection with a strain resembling a vaccine candidate did not confer protection against subsequent rotavirus infection or diarrhea of any severity in this setting.
authors.affiliation: Department of Gastrointestinal Sciences, Christian Medical College, Vellore 632 004, India.
authors.forename: Indrani
authors.initials: I
authors.lastname: Banerjee
authors.forename: Beryl Primrose
authors.initials: BP
authors.lastname: Gladstone
authors.forename: Andrea M
authors.initials: AM
authors.lastname: Le Fevre
authors.forename: Sasirekha
authors.initials: S
authors.lastname: Ramani
authors.forename: Miren
authors.initials: M
authors.lastname: Iturriza-Gomara
authors.forename: James J
authors.initials: JJ
authors.lastname: Gray
authors.forename: David W
authors.initials: DW
authors.lastname: Brown
authors.forename: Mary K
authors.initials: MK
authors.lastname: Estes
authors.forename: Jaya Prakash
authors.initials: JP
authors.lastname: Muliyil
authors.forename: Shabbar
authors.initials: S
authors.lastname: Jaffar
authors.forename: Gagandeep
authors.initials: G
authors.lastname: Kang
mesh_terms: D000328:Adult; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007194:India / Q000453:epidemiology; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D012401:Rotavirus / Q000145:classification*; D012400:Rotavirus Infections / Q000453:epidemiology / Q000276:immunology* / Q000821:virology*