title: Clozapine for the treatment of neurogenic bladder.
abstract: Neurogenic bladder leading to urinary incontinence has been described in patients of stroke, dementia, Parkinson's disease, and some schizophrenia cases with cognitive impairment possibly due to impaired cortical inhibition of the urinary bladder. The underlying brain abnormalities for urinary incontinence are similar in such cases. We report here such a case of neurogenic bladder responding to treatment with clozapine. The possible mechanism of action and clinical implications are described.
authors.affiliation: Department of Psychiatry, All India Institute of Medical Sciences (AIIMS), New Delhi, India.
authors.forename: Amardeep
authors.initials: A
authors.lastname: Kumar
authors.affiliation: Department of Psychiatry, All India Institute of Medical Sciences (AIIMS), New Delhi, India.
authors.forename: R K
authors.initials: RK
authors.lastname: Chadda
authors.affiliation: Department of Psychiatry, All India Institute of Medical Sciences (AIIMS), New Delhi, India.
authors.forename: Nand
authors.initials: N
authors.lastname: Kumar
authors.affiliation: Department of Psychiatry, All India Institute of Medical Sciences (AIIMS), New Delhi, India.
authors.forename: Sabish
authors.initials: S
authors.lastname: Balan
authors.affiliation: Department of Psychiatry, All India Institute of Medical Sciences (AIIMS), New Delhi, India.
authors.forename: Shiva
authors.initials: S
authors.lastname: Prakash Srinivasan
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D003024:Clozapine / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D011877:Radionuclide Imaging; D012559:Schizophrenia / Q000150:complications / Q000188:drug therapy; D012565:Schizophrenic Psychology; D001750:Urinary Bladder, Neurogenic / Q000000981:diagnostic imaging / Q000188:drug therapy*; D053202:Urinary Incontinence, Urge / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy; D014563:Urodynamics
chemical_list: D014150:Antipsychotic Agents; D003024:Clozapine