Chlorahololides A and B, two potent and selective blockers of the potassium channel isolated from Chloranthus holostegius.
[structure: see text] Chlorahololides A(1) and B(2), two highly complex sesquiterpenoid dimers, were isolated from Chloranthus holostegius. Their structures and absolute configurations were established by NMR spectroscopy, X-ray crystallography, and CD. Chlorahololides A (1) and B (2) exhibited potent and selective inhibition on the delayed rectifier (IK) K+ current, with an IC50 of 10.9 and 18.6 microM, respectively.
Yang
Sheng-Ping
SP
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai, 201203, PRC.
Gao
Zhao-Bing
ZB
Wang
Fang-Dao
FD
Liao
Shang-Gao
SG
Chen
Hua-Dong
HD
Zhang
Chuan-Rui
CR
Hu
Guo-Yuan
GY
Yue
Jian-Min
JM
D002942:Circular Dichroism; D018360:Crystallography, X-Ray; D009682:Magnetic Resonance Spectroscopy; D019684:Magnoliopsida / Q000737:chemistry* / Q000378:metabolism; D008958:Models, Molecular; D015394:Molecular Structure; D026902:Potassium Channel Blockers / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology; D013237:Stereoisomerism
D026902:Potassium Channel Blockers; D012717:Sesquiterpenes; C519126:chlorahololide A; C519127:chlorahololide B