Epithelial ovarian cancer at a cancer hospital in a developing country.
OBJECTIVE
To analyze records of patients seen with malignant epithelial ovarian cancer at a tertiary care cancer hospital in Pakistan and obtain information on factors as laterality, histology, CA-125 levels, and stage of the disease, determine age at presentation and, assess menopausal status of the patients. Also, to review results obtained in light of data published in indexed journals.


METHODS
We analyzed 544 cases of malignant ovarian epithelial tumors registered at the Shaukat Khanum Memorial Cancer Hospital and Research Center from December 1994-December 2003.


RESULTS
Mean age at presentation: 48.1 years (SD 13, range 4-82 years); commonest histological sub-type: serous cystadenocarcinoma (28.6%); most frequently seen stage: 3 (43.5%), followed by stage 4 (22.4%); post-menopausal: 56.8% of the women; bilateral disease: 41.2% of the women; and Cancer Antigen-125 (CA-125) level: elevated in 70% of the females.


CONCLUSIONS
Stage at presentation in majority of the cases was advanced as compared to that seen in the west. With only minor variations, our findings seem consistent with those reported in other local studies. However, it is imperative to conduct an extensive population-based study to understand the impact of, and develop strategies for the management of ovarian cancer in Pakistan.
Sarwar
C M Shahbaz
CM
Cancer Registry and Clinical Data Management, Shaukat Khanum Memorial Cancer Hospital and Research Center, P O Box 13014, Lahore, Pakistan.
Siddiqui
Neelam
N
Khokhar
Rizwan Anwar
RA
Badar
Farhana
F
D000367:Age Factors; D002277:Carcinoma / Q000453:epidemiology* / Q000473:pathology; D003906:Developing Countries; D005260:Female; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000453:epidemiology* / Q000473:pathology; D010154:Pakistan / Q000453:epidemiology; D012307:Risk Factors