title: Drug hypersensitivity syndrome caused by minocycline.
abstract: BACKGROUND
  Minocycline is a commonly prescribed drug for the treatment of acne. Its use is generally not associated with systemic side effects.
  
  
  OBJECTIVE
  To describe a case of minocycline-induced drug hypersensitivity syndrome in a 20-year-old Japanese woman.
  
  
  RESULTS
  Following 2 months of minocycline treatment, the patient developed skin lesions composed of exudative maculopapules, purpuratous macules, and target-like, erythema multiforme-like plaques over most of her body. In addition, she had fever, abnormal liver function tests, eosinophilia, and atypical lymphocytosis. Laboratory tests indicated no elevation of antibody titers against cytomegalovirus, Epstein-Barr virus, and human herpesvirus 6. Her ongoing exposure to minocycline was stopped, and treatment with oral prednisolone was begun. Her signs, symptoms, and laboratory abnormalities then began to resolve. Subsequently, the syndrome was observed to return briefly in response to an oral challenge with minocycline.
  
  
  CONCLUSIONS
  Minocycline is able to elicit a drug hypersensitivity syndrome that can resemble infectious mononucleosis. This drug reaction can be treated effectively by cessation of exposure to this drug and steroid therapy.
authors.affiliation: Department of Dermatology, Osaka City University Graduate School of Medicine, Osaka, Japan. dtsuruta@med.osaka-cu.ac.jp
authors.forename: Daisuke
authors.initials: D
authors.lastname: Tsuruta
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Someda
authors.forename: Junko
authors.initials: J
authors.lastname: Sowa
authors.forename: Hiromi
authors.initials: H
authors.lastname: Kobayashi
authors.forename: Masamitsu
authors.initials: M
authors.lastname: Ishii
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy*; D000328:Adult; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D004342:Drug Hypersensitivity / Q000209:etiology*; D005260:Female; D006801:Humans; D008911:Minocycline / Q000009:adverse effects*
chemical_list: D000900:Anti-Bacterial Agents; D008911:Minocycline