title: Efficacy of Carisolv as an adjunctive therapy to scaling and root planing on subgingival calculus removal.
abstract: The purpose of this study was to evaluate the effectiveness of subgingival application of Carisolv gel as an adjunctive therapy to scaling and root planing (SRP) on calculus removal compared to conventional instrumentation. Forty-five teeth requiring extraction due to severe periodontal disease were randomized to the following treatments: 1) SRP alone; 2) placebo gel + SRP; 3) Carisolv gel + SRP. Either test or placebo gel was applied subgingivally for 1 min and then the root were instrumented until a smooth and calculus-free surface was achieved. Instrumentation time and the number of strokes required were recorded. After extraction, the efficacy of root surface instrumentation was measured by percentage of remaining calculus. There was no statistically significant difference (p>0.05) between the treatment groups regarding either time required for instrumentation or the percentage of residual calculus. The subgingival application of Carisolv gel prior to SRP did not provide any additional benefit to root instrumentation compared to scaling and root planing alone.
authors.affiliation: Department of Diagnosis and Surgery, State University of São Paulo, Araraquara, SP, Brazil.
authors.forename: Daniela C
authors.initials: DC
authors.lastname: Grisi
authors.forename: Sérgio Luiz de Souza
authors.initials: SL
authors.lastname: Salvador
authors.forename: Rosemary Adriana Chiérici
authors.initials: RA
authors.lastname: Marcantonio
mesh_terms: D000328:Adult; D003728:Dental Calculus / Q000188:drug therapy* / Q000628:therapy; D012534:Dental Scaling / Q000295:instrumentation / Q000379:methods; D005260:Female; D018698:Glutamic Acid / Q000627:therapeutic use*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007930:Leucine / Q000627:therapeutic use*; D008239:Lysine / Q000627:therapeutic use*; D008297:Male; D023861:Photography, Dental; D010919:Placebos; D016745:Root Planing / Q000295:instrumentation / Q000379:methods; D012997:Solvents / Q000627:therapeutic use*; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: C119934:Carisolv; D010919:Placebos; D012997:Solvents; D018698:Glutamic Acid; D007930:Leucine; D008239:Lysine