DRS is far less divergent than streptococcal inhibitor of complement of group A streptococcus.
When 100 group A streptococcus isolates were screened, drs, a variant of sic, was identified in emm12 and emm55 isolates. Molecular characterization showed that the drs gene sequence is highly conserved, unlike the sic gene sequence. However, the variation in gene size observed was due to the presence of extra internal repeat sequences.
Sagar
Vivek
V
Department of Experimental Medicine and Biotechnology, PGIMER, Chandigarh, 160012 India.
Kumar
Rajesh
R
Ganguly
Nirmal K
NK
Menon
Thangam
T
Chakraborti
Anuradha
A
D000595:Amino Acid Sequence; D001426:Bacterial Proteins / Q000235:genetics*; D005816:Genetic Complementation Test; D014644:Genetic Variation; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D013297:Streptococcus pyogenes / Q000235:genetics*
D001426:Bacterial Proteins; C097739:SIC protein, Streptococcus