Increase of multiple pregnancies caused by ovulation induction with gonadotropin in combination with metformin in infertile women with polycystic ovary syndrome.
Metformin appears to be an effective medicine to induce ovulation in women with polycystic ovary syndrome and insulin resistance. After the introduction of metformin treatment for such cases, the use of gonadotropin in combination with metformin significantly increased the incidence of multiple pregnancies.
Shibahara
Hiroaki
H
Department of Obstetrics and Gynecology, School of Medicine, Jichi Medical University, Tochigi, Japan. sibahara@jichi.ac.jp <sibahara@jichi.ac.jp>
Kikuchi
Kumiko
K
Hirano
Yuki
Y
Suzuki
Tatsuya
T
Takamizawa
Satoru
S
Suzuki
Mitsuaki
M
D000328:Adult; D004359:Drug Therapy, Combination; D005260:Female; D006062:Gonadotropins / Q000627:therapeutic use*; D006801:Humans; D007247:Infertility, Female / Q000150:complications*; D008687:Metformin / Q000627:therapeutic use*; D011085:Polycystic Ovary Syndrome / Q000150:complications*; D011247:Pregnancy; D018873:Pregnancy Rate; D011272:Pregnancy, Multiple / Q000187:drug effects / Q000706:statistics & numerical data*
D006062:Gonadotropins; D008687:Metformin