Practical synthesis of chiral 9,9'-spirobixanthene-1,1'-diol.
A concise four-step synthesis of 9,9'-spirobixanthene-1,1'-diol is reported, featuring a practical preparation at large scale without the use of column chromatography purification. Co-crystallization with N-benzylcinchonidinium chloride and N-benzylquininium chloride rendered the optically pure product in both enantiomers.
Zhang
Weicheng
W
Department of Chemistry, the Pennsylvania State University, University Park, PA 16802, USA.
Wu
Shulin
S
Zhang
Zhaoguo
Z
Yennawar
Hemant
H
Zhang
Xumu
X
D008958:Models, Molecular; D015394:Molecular Structure; D013141:Spiro Compounds / Q000138:chemical synthesis*; D014966:Xanthenes / Q000138:chemical synthesis*
C518277:9,9'-spirobixanthene-1,1'-diol; D013141:Spiro Compounds; D014966:Xanthenes