title: [Clinicopathological characteristics of uninvestigated dyspepsia in Spain].
abstract: BACKGROUND
  Most patients with uninvestigated dyspepsia are diagnosed with functional dyspepsia. Various types of Helicobacter pylori gastritis have been described, each of which is associated with a distinct natural history of the infection (i.e. a different risk of ulcer or gastric cancer).
  
  
  OBJECTIVE
  To determine the clinical and pathological characteristics of patients with uninvestigated dyspepsia in our area and the prevalence of the distinct types of H. pylori gastritis among patients with functional dyspepsia.
  
  
  METHODS
  Ninety-eight patients (47 men and 51 women, mean age 35.8+/-13 years) with uninvestigated dyspepsia were included in this study. All the patients completed the Dyspepsia-Related Health Scale and all patients underwent gastroscopy with biopsy and the C13-urea breath test.
  
  
  RESULTS
  Fourteen patients had organic causes of dyspepsia and 78 had functional dyspepsia. Fifty-one patients with functional dyspepsia (65%) had H. pylori infection; of these, 27 had pangastritis, 21 had antrum-predominant gastritis, 2 had multifocal atrophic gastritis and 1 had normal gastric mucosa. Among uninfected patients, 2 had multifocal atrophic gastritis.
  
  
  CONCLUSIONS
  The prevalence of functional dyspepsia in this series was 85%. Twenty-seven percent of patients with functional dyspepsia had a combination of H. pylori infection and antrum-predominant gastritis, the type of gastritis predisposing to duodenal ulcer. Only 5% of the patients had multifocal atrophic gastritis, which is associated with a high risk of gastric cancer.
authors.affiliation: Servicio de Aparato Digestivo, Hospital Virgen de la Salud, Toledo, Spain.
authors.forename: María José
authors.initials: MJ
authors.lastname: Pérez-Grueso Macías
authors.forename: Julio
authors.initials: J
authors.lastname: Valle Muñoz
authors.forename: Concepción
authors.initials: C
authors.lastname: González de Frutos
authors.forename: Tomás
authors.initials: T
authors.lastname: Artaza Varasa
authors.forename: Rufo
authors.initials: R
authors.lastname: Rodríguez-Merlo
authors.forename: Mariano
authors.initials: M
authors.lastname: Alcántara Torres
authors.forename: José María
authors.initials: JM
authors.lastname: Carrobles Jiménez
mesh_terms: D000328:Adult; D004415:Dyspepsia / Q000382:microbiology* / Q000473:pathology*; D005260:Female; D005756:Gastritis / Q000382:microbiology*; D016481:Helicobacter Infections / Q000150:complications*; D016480:Helicobacter pylori / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D013030:Spain