title: Novel tricalcium silicate/monocalcium phosphate monohydrate composite bone cement.
abstract: In this paper, we obtained a novel bone cement composed of tricalcium silicate (Ca(3)SiO(5); C(3)S) and monocalcium phosphate monohydrate (MCPM). The weight ratio of MCPM in the cement is 0, 10, 20, and 30%. The initial setting time was dramatically reduced from 90 min to 30 min as the content of MCPM reached 20%. The workable paste with a liquid/powder (L/P) ratio of 0.8 mL/g could be injected for 2-20 min (nozzle diameter 2.0 mm). The pH variation of the composite cement in simulated body environment was obviously lowered. The compressive strength of the composite cement after setting for 4-28 days was slightly lower than that of the tricalcium silicate paste. The in vitro bioactivity was investigated by soaking in simulated body fluid for 7 days. The result showed that the novel bone cement had good bioactivity and could degrade in tris-(hydroxymethyl)-aminomethane-hydrochloric-acid (Tris-HCl) solution. Our result indicated that the Ca(3)SiO(5)/MCPM paste had good hydraulic properties, bioactivity, and degradability. The novel bone cement could be a potential candidate as bone substitute.
authors.affiliation: Biomaterials and Tissue Engineering Research Center, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Dingxi Road, Shanghai 200050, People's Republic of China.
authors.forename: Zhiguang
authors.initials: Z
authors.lastname: Huan
authors.forename: Jiang
authors.initials: J
authors.lastname: Chang
mesh_terms: D001031:Apatites / Q000737:chemistry; D001843:Bone Cements / Q000737:chemistry*; D018786:Bone Substitutes / Q000737:chemistry*; D017610:Calcium Compounds / Q000737:chemistry*; D002130:Calcium Phosphates / Q000737:chemistry*; D019245:Compressive Strength; D006863:Hydrogen-Ion Concentration; D008422:Materials Testing; D017640:Silicates / Q000737:chemistry*
chemical_list: D001031:Apatites; D001843:Bone Cements; D018786:Bone Substitutes; D017610:Calcium Compounds; D002130:Calcium Phosphates; D017640:Silicates; C506393:tricalcium silicate; C485838:calcium phosphate, monobasic, anhydrous