[Hydroxyzine premedication does not alter bispectral index changes following etomidate induction of general anaesthesia].
OBJECTIVE
Various drugs including hydroxyzine are preoperatively administered to facilitate the induction of general anaesthesia. We investigated the effect of hydroxyzine premedication on BIS-based etomidate induction of general anaesthesia.


METHODS
Sixty-seven ASA I-II consecutive patients were randomly allocated to receive oral hydroxyzine 1.5 mg/kg or placebo, 90 min prior to inducing general anaesthesia using intravenous etomidate alone 0.3 mg/kg. BIS values were continuously recorded. The times for the BIS to decrease to 50 and to loss of eyelid reflex; the evolution of arterial pressure and heart rate; and myoclonia rate and grade were investigated and compared.


RESULTS
The results for the hydroxyzine and placebo groups were similar with respect to: a) time [median (range) (seconds)] to a BIS decrease to 50 [100 (21-266) versus 113 (30-510), P=0.1] and to loss of eyelid reflex [83 (21-210) versus 97 (30-300), P=0.1]; b) myoclonia frequency (yes/no) (9/26 versus 4/28, P=0.2) and grade (P=0.3); the evolution of mean arterial pressure and heart rate (P=0.3).


CONCLUSIONS
Oral weight-related hydroxyzine premedication does not alter BIS-based etomidate induction of GA.
Lallemand
M-A
MA
Service d'anesthésie-réanimation, faculté de médecine, université Paris-V-René-Descartes, hôpital Cochin, EA 3623, Assistance publique-Hôpitaux de Paris, 27, rue du Faubourg Saint-Jacques, 75679 Paris cedex 14, France.
Lentschener
C
C
Roche
K
K
Grabar
S
S
Bonnichon
P
P
Ozier
Y
Y
D000284:Administration, Oral; D000328:Adult; D000768:Anesthesia, General / Q000379:methods*; D018686:Anesthetics, Intravenous / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D005045:Etomidate / Q000627:therapeutic use*; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006634:Histamine H1 Antagonists / Q000008:administration & dosage*; D006801:Humans; D006919:Hydroxyzine / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged
D018686:Anesthetics, Intravenous; D006634:Histamine H1 Antagonists; D006919:Hydroxyzine; D005045:Etomidate