Multiple levels of cyclin specificity in cell-cycle control.
Cyclins regulate the cell cycle by binding to and activating cyclin-dependent kinases (Cdks). Phosphorylation of specific targets by cyclin-Cdk complexes sets in motion different processes that drive the cell cycle in a timely manner. In budding yeast, a single Cdk is activated by multiple cyclins. The ability of these cyclins to target specific proteins and to initiate different cell-cycle events might, in some cases, reflect the timing of the expression of the cyclins; in others, it might reflect intrinsic properties of the cyclins that render them better suited to target particular proteins.
Bloom
Joanna
J
Laboratory of Yeast Molecular Genetics, Rockefeller University, 1230 York Avenue, New York, New York 10021, USA.
Cross
Frederick R
FR
D002453:Cell Cycle; D018844:Cyclin-Dependent Kinases / Q000378:metabolism*; D016213:Cyclins / Q000235:genetics / Q000502:physiology*; D019143:Evolution, Molecular; D015966:Gene Expression Regulation, Fungal; D010766:Phosphorylation; D004718:Saccharomycetales / Q000378:metabolism* / Q000502:physiology; D015398:Signal Transduction
D016213:Cyclins; D018844:Cyclin-Dependent Kinases