title: Synchrotron-based intravenous cerebral angiography in a small animal model.
abstract: K-edge digital subtraction angiography (KEDSA), a recently developed synchrotron-based technique, utilizes monochromatic radiation and allows acquisition of high-quality angiography images after intravenous administration of contrast agent. We tested KEDSA for its suitability for intravenous cerebral angiography in an animal model. Adult male New Zealand rabbits were subjected to either angiography with conventional x-ray equipment or synchrotron-based intravenous KEDSA, using an iodine-based contrast agent. Angiography with conventional x-ray equipment after intra-arterial administration of contrast agent demonstrated the major intracranial vessels but no smaller branches. KEDSA was able to visualize the major intracranial vessels as well as smaller branches in both radiography mode (planar images) and tomography mode. Visualization was achieved with as little as 0.5 ml kg-1 of iodinated contrast material. We were able to obtain excellent visualization of the cerebral vasculature in an animal model using intravenous injection of contrast material, using synchrotron-based KEDSA.
authors.affiliation: Division of Neurosurgery, Royal University Hospital, University of Saskatchewan, Saskatoon, SK, Canada. kellym@ccf.org
authors.forename: Michael E
authors.initials: ME
authors.lastname: Kelly
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Schültke
authors.forename: Stephan
authors.initials: S
authors.lastname: Fiedler
authors.forename: Christian
authors.initials: C
authors.lastname: Nemoz
authors.forename: Raphael
authors.initials: R
authors.lastname: Guzman
authors.forename: Stephanie
authors.initials: S
authors.lastname: Corde
authors.forename: Francois
authors.initials: F
authors.lastname: Esteve
authors.forename: Geraldine
authors.initials: G
authors.lastname: LeDuc
authors.forename: Bernhard H J
authors.initials: BH
authors.lastname: Juurlink
authors.forename: Kotoo
authors.initials: K
authors.lastname: Meguro
mesh_terms: D015901:Angiography, Digital Subtraction / Q000295:instrumentation / Q000379:methods*; D000818:Animals; D002533:Cerebral Angiography / Q000295:instrumentation / Q000379:methods*; D002536:Cerebral Arteries / Q000000981:diagnostic imaging / Q000473:pathology; D003287:Contrast Media / Q000008:administration & dosage / Q000494:pharmacology; D007260:Infusion Pumps; D008297:Male; D023421:Models, Animal; D011817:Rabbits; D011877:Radionuclide Imaging; D017356:Synchrotrons
chemical_list: D003287:Contrast Media