Cadherin-11 in synovial lining formation and pathology in arthritis.
The normal synovium forms a membrane at the edges of joints and provides lubrication and nutrients for the cartilage. In rheumatoid arthritis, the synovium is the site of inflammation, and it participates in an organized tissue response that damages cartilage and bone. We identified cadherin-11 as essential for the development of the synovium. Cadherin-11-deficient mice have a hypoplastic synovial lining, display a disorganized synovial reaction to inflammation, and are resistant to inflammatory arthritis. Cadherin-11 therapeutics prevent and reduce arthritis in mouse models. Thus, synovial cadherin-11 determines the behavior of synovial cells in their proinflammatory and destructive tissue response in inflammatory arthritis.
Lee
David M
DM
Department of Medicine and Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, 1 Jimmy Fund Way, Boston, MA 02115, USA.
Kiener
Hans P
HP
Agarwal
Sandeep K
SK
Noss
Erika H
EH
Watts
Gerald F M
GF
Chisaka
Osamu
O
Takeichi
Masatoshi
M
Brenner
Michael B
MB
D000818:Animals; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D001169:Arthritis, Experimental; D001172:Arthritis, Rheumatoid / Q000378:metabolism / Q000473:pathology* / Q000628:therapy; D015820:Cadherins / Q000037:antagonists & inhibitors* / Q000096:biosynthesis / Q000172:deficiency / Q000502:physiology*; D002448:Cell Adhesion / Q000502:physiology; D004195:Disease Models, Animal; D005109:Extracellular Matrix / Q000378:metabolism; D005347:Fibroblasts / Q000378:metabolism; D007739:L Cells; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009924:Organ Culture Techniques; D013583:Synovial Membrane / Q000166:cytology* / Q000473:pathology*
D000911:Antibodies, Monoclonal; D015820:Cadherins; C086960:osteoblast cadherin