title: Fetal leukemia with umbilical artery embolism and circulatory failure.
abstract: BACKGROUND
  This is a case report of fetal leukemia associated with hydramnios.
  
  
  METHODS
  When the hydramnios was treated with amnioreduction, near-term bradycardia was recorded ultrasonographically, resulting in immediate cesarean delivery. At birth, neonatal leukemia was diagnosed and there was no evidence of chromosomal abnormalities. The infant died of pulmonary hemorrhage. Autopsy showed umbilical venous embolization with tumor cells, and there was arterial invasion of the vessel wall by tumor.
  
  
  CONCLUSIONS
  Fetal leukemia is extremely rare, and its prenatal diagnosis is difficult. In cases of hepatomegaly, fetal leukemia should be considered in the differential diagnosis.
authors.affiliation: Department of Obstetrics and Gynecology, National Defense Medical College, Saitama, Japan. tom-s@momo.so-net.ne.jp
authors.forename: Tomoko
authors.initials: T
authors.lastname: Shibasaki
authors.forename: Hideo
authors.initials: H
authors.lastname: Matsuda
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Kawakami
authors.forename: Kenichi
authors.initials: K
authors.lastname: Furuya
mesh_terms: D000328:Adult; D002585:Cesarean Section; D003937:Diagnosis, Differential; D004617:Embolism / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D017809:Fatal Outcome; D005260:Female; D005315:Fetal Diseases / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D007231:Infant, Newborn; D007938:Leukemia / Q000150:complications / Q000151:congenital / Q000175:diagnosis* / Q000473:pathology; D011247:Pregnancy; D011263:Pregnancy Trimester, Third; D011296:Prenatal Diagnosis; D012769:Shock; D014469:Umbilical Arteries