title: Metabolites from the Lichen Ochrolechia parella growing under two different heliotropic conditions.
abstract: A new chloro-depsidone (1) and five known compounds, variolaric acid (2), lecanoric acid (3), alpha-alectoronic acid (4), atranorin (5), and ergosterol peroxide (6), have been isolated from the lichen Ochrolechia parella. The structure of compound 1 was elucidated by spectroscopic analysis. Additionally, the tautomeric equilibrium of compound 4 was investigated. In the present study, two specimens of this lichen, growing under different light conditions, were analyzed. The major compound in both samples was found to be 2, but the amount of this metabolite was significantly higher in the shaded specimen (0.76% w/w). The new compound parellin (1) predominated in the specimen grown under shady conditions, while atranorin (5) was found only in the sunlit specimen. The cytotoxic activities of 2, 4, and 6 against B16 melanoma cells were evaluated.
authors.affiliation: Institut de Chimie de Rennes, EA 4090 Substances Lichéniques et Photoprotection, Faculté de Pharmacie, 2 Avenue du Professeur Léon Bernard, 35043 Rennes Cedex, France.
authors.forename: Marion
authors.initials: M
authors.lastname: Millot
authors.forename: Sophie
authors.initials: S
authors.lastname: Tomasi
authors.forename: Kristina
authors.initials: K
authors.lastname: Articus
authors.forename: Isabelle
authors.initials: I
authors.lastname: Rouaud
authors.forename: Aurélie
authors.initials: A
authors.lastname: Bernard
authors.forename: Joël
authors.initials: J
authors.lastname: Boustie
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D053630:Depsides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005602:France; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008011:Lichens / Q000737:chemistry*; D015394:Molecular Structure
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D053630:Depsides; D007783:Lactones; C518563:parellin; C000875:depsidone