A role for Caenorhabditis elegans chromatin-associated protein HIM-17 in the proliferation vs. meiotic entry decision.
Chromatin-associated protein HIM-17 was previously shown to function in the chromosomal events of meiotic prophase. Here we report an additional role for HIM-17 in regulating the balance between germ cell proliferation and meiotic development. A cryptic function for HIM-17 in promoting meiotic entry and/or inhibiting proliferation was revealed by defects in germline organization in him-17 mutants grown at high temperature (25 degrees) and by a synthetic tumorous germline phenotype in glp-1(ar202); him-17 mutants at 15 degrees.
Bessler
Jessica B
JB
Department of Developmental Biology, Stanford University School of Medicine, Stanford, California 94305, USA.
Reddy
Kirthi C
KC
Hayashi
Michiko
M
Hodgkin
Jonathan
J
Villeneuve
Anne M
AM
D000818:Animals; D030801:Animals, Genetically Modified; D017173:Caenorhabditis elegans / Q000166:cytology* / Q000235:genetics / Q000502:physiology*; D029742:Caenorhabditis elegans Proteins / Q000235:genetics / Q000502:physiology*; D018797:Cell Cycle Proteins / Q000235:genetics / Q000502:physiology*; D049109:Cell Proliferation; D005260:Female; D020868:Gene Silencing; D017238:Genes, Helminth; D018095:Germ-Line Mutation; D008297:Male; D008540:Meiosis / Q000235:genetics / Q000502:physiology; D009154:Mutation; D009374:Neoplasms, Experimental / Q000235:genetics; D010641:Phenotype; D012098:Reproduction / Q000235:genetics / Q000502:physiology; D013696:Temperature
D029742:Caenorhabditis elegans Proteins; D018797:Cell Cycle Proteins; C491265:HIM-17 protein, C elegans