CLOCK gene 3111C/T polymorphism is not associated with seasonal variations in mood and behavior in Korean college students.
The present study tested the potential association between the 3111C/T polymorphism of the CLOCK gene and seasonal variations in mood and behavior. A total of 297 Korean college students were genotyped for the CLOCK polymorphism and the seasonal variation was evaluated using the Seasonal Pattern Assessment Questionnaire (SPAQ). The seasonality scores were not different between CLOCK gene variants (P > 0.05). Comparison between seasonals (syndromal plus subsyndromal seasonal affective disorder according to SPAQ) and non-seasonals found no significant difference in frequencies of genotypes (P > 0.05). These findings suggest that the CLOCK polymorphism does not play a major role in susceptibility to seasonal variations in a Korean population.
Paik
Jong-Woo
JW
Department of Psychiatry, Korea University College of Medicine, Seoul, Korea.
Lee
Heon-Jeong
HJ
Kang
Seong-Gul
SG
Lim
Se-Won
SW
Lee
Min-Soo
MS
Kim
Leen
L
D000328:Adult; D000339:Affect / Q000502:physiology*; D000483:Alleles; D001519:Behavior / Q000502:physiology*; D056926:CLOCK Proteins; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007723:Korea / Q000453:epidemiology; D008297:Male; D011110:Polymorphism, Genetic / Q000235:genetics*; D016574:Seasonal Affective Disorder / Q000453:epidemiology / Q000235:genetics* / Q000523:psychology*; D012621:Seasons; D013337:Students, Medical; D011795:Surveys and Questionnaires; D015534:Trans-Activators / Q000235:genetics* / Q000502:physiology*
D015534:Trans-Activators; D056926:CLOCK Proteins; C538943:CLOCK protein, human