title: Detection of the subthalamic nucleus in microelectrographic recordings in Parkinson disease using the high-frequency (> 500 hz) neuronal background. Technical note.
abstract: Accurate and fast localization of the subthalamic nucleus (STN) during intraoperative electrophysiological monitoring can improve the outcome of deep brain stimulation surgery. The authors show a simple method of detecting the STN that is based on an analysis of the high-frequency (> 500 Hz) background (HFB) activity of neurons. The HFB reflects multiunit spiking activity close to the recording electrode, and its characteristic profile, which is higher in the STN than in neighboring structures, and facilitates delineation of both the dorsal and ventral STN borders.
authors.affiliation: Department of Neurology, Boston University School of Medicine, Boston, Massachusetts 02118, USA. peter.novak@bmc.org
authors.forename: Peter
authors.initials: P
authors.lastname: Novak
authors.forename: Slawomir
authors.initials: S
authors.lastname: Daniluk
authors.forename: Samuel A
authors.initials: SA
authors.lastname: Ellias
authors.forename: Jules M
authors.initials: JM
authors.lastname: Nazzaro
mesh_terms: D000368:Aged; D046690:Deep Brain Stimulation; D004553:Electric Conductivity; D004569:Electroencephalography / Q000295:instrumentation / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008839:Microelectrodes; D008875:Middle Aged; D016343:Monitoring, Intraoperative / Q000295:instrumentation / Q000379:methods*; D009474:Neurons / Q000502:physiology*; D010300:Parkinson Disease / Q000503:physiopathology* / Q000601:surgery; D012189:Retrospective Studies; D020531:Subthalamic Nucleus / Q000503:physiopathology*