title: Modulation of lipid rafts by Omega-3 fatty acids in inflammation and cancer: implications for use of lipids during nutrition support.
abstract: Current understanding of biologic membrane structure and function is largely based on the concept of lipid rafts. Lipid rafts are composed primarily of tightly packed, liquid-ordered sphingolipids/cholesterol/saturated phospholipids that float in a sea of more unsaturated and loosely packed, liquid-disordered lipids. Lipid rafts have important clinical implications because many important membrane-signaling proteins are located within the raft regions of the membrane, and alterations in raft structure can alter activity of these signaling proteins. Because rafts are lipid-based, their composition, structure, and function are susceptible to manipulation by dietary components such as omega-3 polyunsaturated fatty acids and by cholesterol depletion. We review how alteration of raft lipids affects the raft/nonraft localization and hence the function of several proteins involved in cell signaling. We focus our discussion of raft-signaling proteins on inflammation and cancer.
authors.affiliation: Methodist Research Institute, Cellular Biochemistry, Indianapolis, IN 46202, USA. rsiddiqu@clarian.org
authors.forename: Rafat A
authors.initials: RA
authors.lastname: Siddiqui
authors.forename: Kevin A
authors.initials: KA
authors.lastname: Harvey
authors.forename: Gary P
authors.initials: GP
authors.lastname: Zaloga
authors.forename: William
authors.initials: W
authors.lastname: Stillwell
mesh_terms: D002462:Cell Membrane / Q000378:metabolism; D015525:Fatty Acids, Omega-3 / Q000378:metabolism / Q000627:therapeutic use; D006801:Humans; D007249:Inflammation / Q000378:metabolism* / Q000628:therapy; D008055:Lipids / Q000737:chemistry*; D021962:Membrane Microdomains / Q000737:chemistry* / Q000502:physiology*; D009369:Neoplasms / Q000378:metabolism* / Q000628:therapy; D018529:Nutritional Support; D013329:Structure-Activity Relationship
chemical_list: D015525:Fatty Acids, Omega-3; D008055:Lipids