Pathophysiological roles of ASK1-MAP kinase signaling pathways.
Apoptosis signal-regulating kinase 1 (ASK1) is a mitogenactivated protein kinase (MAPK) kinase kinase that activates JNK and p38 kinases. ASK1 is activated by various stresses, such as reactive oxygen species (ROS), endoplasmic reticulum (ER) stress, lipopolysaccharide (LPS) and calcium influx which are thought to be responsible for the pathogenesis or exacerbations of various human diseases. Recent studies revealed the involvement of ASK1 in ROS- or ER stressrelated diseases, suggesting that ASK1 may be a potential therapeutic target of various human diseases. In this review, we focus on the current findings for the relationship between pathogenesis and ASK1-MAPK pathways.
Nagai
Hiroaki
H
Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Japan.
Noguchi
Takuya
T
Takeda
Kohsuke
K
Ichijo
Hidenori
H
D000818:Animals; D004194:Disease / Q000209:etiology*; D006801:Humans; D007107:Immune System / Q000502:physiology; D048848:MAP Kinase Kinase Kinase 5 / Q000502:physiology*; D020935:MAP Kinase Signaling System / Q000502:physiology*; D008954:Models, Biological; D019636:Neurodegenerative Diseases / Q000209:etiology; D018384:Oxidative Stress
D048848:MAP Kinase Kinase Kinase 5