title: Loading and delivery of sertraline using inorganic micro and mesoporous materials.
abstract: Sertraline hydrochloride (designated as sertraline from now on) is an antidepressive drug with unpleasant effects in the gastric tract. Therefore, improved means of delivery allowing for a more controlled and efficient release were looked for. Two different porous materials, montmorillonite-K10 and MCM-41, were chosen as hosts. The drug was intercalated in the interlayer spacing of the clay by cation exchange and was loaded inside the MCM-41 channels by pore volume impregnation means. Spectroscopic evidence (UV/vis, FTIR, powder X-ray diffraction (XRD) and (13)C CP/MAS and (29)Si CP/MAS and MAS solid-state NMR), as well as elemental analysis, complemented by DFT calculations, demonstrated the presence of sertraline in the composite materials. The release processes were monitored under in vitro conditions using a simulated body fluid. The release profile from the clay is fast, indicating that a concentration peak is reached in a short period of time, while the release profile from MCM is slower but lasts longer. These differences are discussed on the basis of different therapeutic indications for both materials.
authors.affiliation: Departamento de Química e Bioquímica, Universidade de Lisboa, Lisboa, Portugal.
authors.forename: Carla D
authors.initials: CD
authors.lastname: Nunes
authors.forename: Pedro D
authors.initials: PD
authors.lastname: Vaz
authors.forename: Ana C
authors.initials: AC
authors.lastname: Fernandes
authors.forename: Paula
authors.initials: P
authors.lastname: Ferreira
authors.forename: Carlos C
authors.initials: CC
authors.lastname: Romão
authors.forename: Maria José
authors.initials: MJ
authors.lastname: Calhorda
mesh_terms: D016503:Drug Delivery Systems; D009682:Magnetic Resonance Spectroscopy; D016062:Porosity; D020280:Sertraline / Q000008:administration & dosage* / Q000737:chemistry; D012995:Solubility; D014961:X-Ray Diffraction
chemical_list: D020280:Sertraline