The balance of thrombosis and hemorrhage in surgery.
Postoperative hemorrhage and thrombosis is a significant problem during the perioperative period. Understanding the complex and dynamic interplay of factors, proteins, and enzymes during coagulation is imperative to maintain balance between hemostasis and thrombosis. To improve patient outcome, each patient should be risk stratified for bleeding or thrombosis during the preoperative examination. Additional research focused on improvement in screening tools, monitoring, and therapeutic regimens for surgical patients with a coagulopathy are warranted.
Adams
George L
GL
Department of Medicine, Duke University Medical Center, Box 2622, MSRB, Research Drive, Durham, NC 27710, USA.
Manson
Roberto J
RJ
Turner
Immanuel
I
Sindram
David
D
Lawson
Jeffrey H
JH
D001777:Blood Coagulation / Q000502:physiology; D006470:Hemorrhage; D006801:Humans; D011183:Postoperative Complications; D013514:Surgical Procedures, Operative; D013927:Thrombosis