title: Association of acyl-CoA-binding protein (ACBP) single nucleotide polymorphisms and type 2 diabetes in two German study populations.
abstract: The human acyl-CoA-binding protein (ACBP) is a potential candidate gene of type 2 diabetes (T2D), since it plays a central role in determining the intracellular concentration of activated fatty acids which contribute to insulin resistance. The aim of our study was to evaluate whether single nucleotide polymorphisms (SNPs) of the ACBP gene are associated with risk of T2D. Genotyping of eight SNPs (rs2084202, rs3731607, rs8192501, rs8192504, rs2244135, rs2276596, rs8192506, rs2289948) was performed in 192 incident T2D subjects and 384 matched controls of the European Prospective Investigation into Cancer and Nutrition-Potsdam cohort. A putative promoter SNP (rs2084202) of splice variant ACBP 1c showed decreased risk of T2D (odds ratio (OR) 0.63, 95% CI 0.41-0.96). The haplotype, that contained the mutant base of rs2084202 showed similar evidence for the association with disease risk as single SNP rs2084202. In a second population-based study, Cooperative Health Research in the Augsburg Region of 226 individuals with T2D and 863 control subjects a borderline significant association between rs2084202 and T2D (OR 0.72, 95% CI 0.51-1.01) was observed. In summary, we obtained evidence from two Caucasian study populations that the minor allele of ACBP rs2084202 might be associated with reduced risk of T2D.
authors.affiliation: Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.
authors.forename: Eva
authors.initials: E
authors.lastname: Fisher
authors.forename: Inke
authors.initials: I
authors.lastname: Nitz
authors.forename: Christian
authors.initials: C
authors.lastname: Gieger
authors.forename: Harald
authors.initials: H
authors.lastname: Grallert
authors.forename: Henning
authors.initials: H
authors.lastname: Gohlke
authors.forename: Inka
authors.initials: I
authors.lastname: Lindner
authors.forename: Stefan
authors.initials: S
authors.lastname: Dahm
authors.forename: Heiner
authors.initials: H
authors.lastname: Boeing
authors.forename: Barbara
authors.initials: B
authors.lastname: Burwinkel
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Rathmann
authors.forename: H-Erich
authors.initials: HE
authors.lastname: Wichmann
authors.forename: Jürgen
authors.initials: J
authors.lastname: Schrezenmeir
authors.forename: Thomas
authors.initials: T
authors.lastname: Illig
authors.forename: Frank
authors.initials: F
authors.lastname: Döring
mesh_terms: D000328:Adult; D000368:Aged; D015992:Body Mass Index; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D026261:Diazepam Binding Inhibitor; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide
chemical_list: D026261:Diazepam Binding Inhibitor