Translocation-positive acute myeloid leukemia associated with valproic acid therapy.
Valproic acid is an effective anti-epileptic medication often used for long-term control of seizure disorders that has been implicated in hematological toxicities, including rare reports of myelodysplasia and acute leukemia. Here, we report a case of valproic acid-related leukemia-like syndrome with a t(8;16) chromosomal translocation. After discontinuing valproic acid, the hematological findings completely resolved.
Williams
David C
DC
Department of Pathology, Virginia Commonwealth University Health System, Richmond, Virginia, USA.
Massey
Gita V
GV
Russell
E Clifton
EC
Riley
Roger S
RS
Ben-Ezra
Jonathan
J
D000208:Acute Disease; D000927:Anticonvulsants / Q000008:administration & dosage / Q000009:adverse effects* / Q000494:pharmacology / Q000627:therapeutic use; D002454:Cell Differentiation; D002455:Cell Division / Q000187:drug effects; D002675:Child, Preschool; D002885:Chromosomes, Human, Pair 16 / Q000235:genetics / Q000648:ultrastructure*; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics / Q000648:ultrastructure*; D002999:Clone Cells / Q000187:drug effects / Q000648:ultrastructure; D003043:Cocarcinogenesis; D004359:Drug Therapy, Combination; D004832:Epilepsy, Absence / Q000188:drug therapy; D005260:Female; D006801:Humans; D007555:Isoxazoles / Q000008:administration & dosage / Q000627:therapeutic use; D000077213:Lamotrigine; D007951:Leukemia, Myeloid / Q000139:chemically induced* / Q000235:genetics / Q000473:pathology; D000077287:Levetiracetam; D014411:Neoplastic Stem Cells / Q000187:drug effects / Q000648:ultrastructure; D015514:Oncogene Proteins, Fusion / Q000235:genetics; D010634:Phenobarbital / Q000008:administration & dosage / Q000627:therapeutic use; D010889:Piracetam / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000627:therapeutic use; D014178:Translocation, Genetic; D014227:Triazines / Q000008:administration & dosage / Q000627:therapeutic use; D014635:Valproic Acid / Q000008:administration & dosage / Q000009:adverse effects* / Q000494:pharmacology / Q000627:therapeutic use; D000078305:Zonisamide
D000927:Anticonvulsants; C470261:CBP-MOZ fusion protein, human; D007555:Isoxazoles; D015514:Oncogene Proteins, Fusion; D014227:Triazines; D000077287:Levetiracetam; D000078305:Zonisamide; D014635:Valproic Acid; D000077213:Lamotrigine; D010634:Phenobarbital; D010889:Piracetam