Interleukin-1 genetic polymorphisms and their relationship to the cancer anorexia/weight loss syndrome in metastatic gastric and gastroesophageal junction adenocarcinoma.
Interleukin-1 (IL-1) beta is a putative mediator of the cancer anorexia/weight loss syndrome, and certain polymorphisms of its gene are thought to be associated with a greater risk of gastric cancer. Do these IL-1 beta genetic polymorphisms predispose patients with gastric and gastroesophageal cancer to the anorexia/weight loss syndrome? This study focused on 44 patients with metastatic gastric and gastroesophageal cancer. All underwent genotyping, completed serial quality-of-life questionnaires germane to appetite, and underwent meticulous serial follow-up. Patients with the IL-1 beta-31 C/T and T/T genotypes were more likely to describe a worse appetite at baseline than were those with the C/C genotype. In addition, patients with the IL-1 beta+3954 C/T and T/T genotypes showed greater improvements in their weight (P = 0.02) and in survival (hazard ratio, 0.3; P = 0.04) over time than did patients with the C/C genotype. These associations occurred independently of tumor response. These preliminary data suggest that certain interleukin-1 beta genetic polymorphisms may modulate the cancer anorexia/weight loss syndrome in patients with metastatic gastric and esophageal cancer. Confirmatory studies are warranted.
Jatoi
Aminah
A
Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA. jatoi.aminah@mayo.edu
Nguyen
Phuong L
PL
Foster
Nathan
N
Sun
David
D
Stella
Philip J
PJ
Campbell
Megan
M
Tschetter
Loren K
LK
Dakhil
Shaker R
SR
Mailliard
James A
JA
Nikcevich
Daniel A
DA
D000230:Adenocarcinoma / Q000150:complications / Q000235:genetics* / Q000556:secondary; D000328:Adult; D000368:Aged; D000855:Anorexia / Q000235:genetics*; D004943:Esophagogastric Junction; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D053583:Interleukin-1beta / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011379:Prognosis; D011446:Prospective Studies; D011788:Quality of Life; D013274:Stomach Neoplasms / Q000150:complications / Q000235:genetics* / Q000473:pathology; D015996:Survival Rate; D013577:Syndrome; D015431:Weight Loss / Q000235:genetics*
D053583:Interleukin-1beta