title: Effects of dexibuprofen on platelet function in humans: comparison with low-dose aspirin.
abstract: BACKGROUND
  The aim of the current study is to evaluate the antiplatelet effect of dexibuprofen in healthy volunteers in comparison with low-dose aspirin.
  
  
  METHODS
  Healthy volunteers (n = 12) were treated in a crossover manner with 100 mg daily aspirin or with 800 mg daily dexibuprofen. Blood samples were obtained within 24 h; 3, 7, and 14 days after repeated doses; and 24 h after the last dose. In each sample, the authors measured platelet aggregation, thromboxane B2, 6-keto-prostaglandin F1alpha, and nitric oxide.
  
  
  RESULTS
  The antiplatelet effect of dexibuprofen (maximal inhibition of aggregation was 48-55% for adenosine diphosphate and 90-95% for collagen and arachidonic acid) was equal to the effect of aspirin. The main difference between the two drugs was in the degree of recovery of platelet function. The effect of aspirin persisted for 24 h after the last dose (remaining inhibition 50%, respect to the pretreatment value), whereas platelet aggregation had returned to baseline pretreatment values within 24 h after dexibuprofen was stopped.
  
  
  CONCLUSIONS
  Both aspirin and dexibuprofen inhibited platelet function with a similar intensity, but dexibuprofen exerted a reversible effect for 24 h after the last dose.
authors.affiliation: Department of Pharmacology and Therapeutics, School of Medicine, University of Malaga, Spain.
authors.forename: José Antonio
authors.initials: JA
authors.lastname: González-Correa
authors.forename: María Monsalud
authors.initials: MM
authors.lastname: Arrebola
authors.forename: Eva
authors.initials: E
authors.lastname: Martín-Salido
authors.forename: Javier
authors.initials: J
authors.lastname: Muñoz-Marín
authors.forename: Felipe Sánchez
authors.initials: FS
authors.lastname: de la Cuesta
authors.forename: José Pedro
authors.initials: JP
authors.lastname: De La Cruz
mesh_terms: D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001241:Aspirin / Q000009:adverse effects / Q000494:pharmacology*; D001792:Blood Platelets / Q000187:drug effects*; D018592:Cross-Over Studies; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology; D005260:Female; D006801:Humans; D007052:Ibuprofen / Q000494:pharmacology*; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D013237:Stereoisomerism
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D016861:Cyclooxygenase Inhibitors; D010975:Platelet Aggregation Inhibitors; D001241:Aspirin; D007052:Ibuprofen