title: [Spanish cohort of naïve HIV-infected patients (CoRIS): rationale, organization and initial results].
abstract: OBJECTIVE
  To describe the methodology and baseline results of the Spanish cohort of naïve HIV-infected patients included in the Research Network on HIV/AIDS (CoRIS).
  
  
  METHODS
  CoRIS is a multicenter, hospital-based prospective cohort of HIV sero-prevalent, retroviral-naïve subjects, over 13 years old, and seen at 17 hospitals in 8 of the 17 Autonomous Regions in Spain from January 2004 to October 2005. The socio-demographic characteristics, as well as epidemiological, clinical, laboratory and treatment data were recorded, and biological samples were collected at baseline and during follow-up.
  
  
  RESULTS
  A total of 1,591 subjects have been included in CoRIS; 24% are women, median age at cohort entry is 36 years, and 74% were diagnosed during 2004 or 2005. Twenty-seven percent came from countries other than Spain, mainly Latin-America (16%) and sub-Saharan Africa (5%). Thirty-two percent had completed secondary education and 16% university studies. The most frequent categories of transmission were men having sex with men (37%) and heterosexual sex (36%); only 21% were injection drug users. At cohort entry, median CD4 count was 317 cells/mm 3 and median viral load was 52,300 copies/mL; 18% were diagnosed with AIDS. Main AIDS-defining illnesses were Pneumocystis jiroveci pneumonia (6.1%), esophageal candidiasis (3.3%) and tuberculosis (extrapulmonary, 3.0% and pulmonary 2.7%). There were 35 deaths (2.2%). Thirty-three percent of patients gave a baseline sample to the BioBank.
  
  
  CONCLUSIONS
  CoRIS offers relevant information about the current epidemiological profile of HIV infection in Spain, where sexual transmission has become predominant. The type and amount of information obtained from clinical and epidemiological data collection together with biological samples demonstrate the viability of the project, which offers many possibilities for future research.
authors.affiliation: Centro Nacional de Epidemiología, Instituto de Salud Carlos III, Madrid, Spain. amcaro@isciii.es
authors.forename: Ana María
authors.initials: AM
authors.lastname: Caro-Murillo
authors.forename: Jesús
authors.initials: J
authors.lastname: Castilla
authors.forename: Santiago
authors.initials: S
authors.lastname: Pérez-Hoyos
authors.forename: José M
authors.initials: JM
authors.lastname: Miró
authors.forename: Daniel
authors.initials: D
authors.lastname: Podzamczer
authors.forename: Rafael
authors.initials: R
authors.lastname: Rubio
authors.forename: Melchor
authors.initials: M
authors.lastname: Riera
authors.forename: Pompeyo
authors.initials: P
authors.lastname: Viciana
authors.forename: José
authors.initials: J
authors.lastname: López Aldeguer
authors.forename: José Antonio
authors.initials: JA
authors.lastname: Iribarren
authors.forename: Ignacio
authors.initials: I
authors.lastname: de los Santos-Gil
authors.forename: Juan Luis
authors.initials: JL
authors.lastname: Gómez-Sirvent
authors.forename: Juan
authors.initials: J
authors.lastname: Berenguer
authors.forename: Félix
authors.initials: F
authors.lastname: Gutiérrez
authors.forename: María
authors.initials: M
authors.lastname: Saumoy
authors.forename: Ferrán
authors.initials: F
authors.lastname: Segura
authors.forename: Vicente
authors.initials: V
authors.lastname: Soriano
authors.forename: Alejandro
authors.initials: A
authors.lastname: Peña
authors.forename: Federico
authors.initials: F
authors.lastname: Pulido
authors.forename: José Antonio
authors.initials: JA
authors.lastname: Oteo
authors.forename: Manuel
authors.initials: M
authors.lastname: Leal
authors.forename: Jordi
authors.initials: J
authors.lastname: Casabona
authors.forename: Julia
authors.initials: J
authors.lastname: del Amo
authors.forename: Santiago
authors.initials: S
authors.lastname: Moreno
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000453:epidemiology; D000293:Adolescent; D000328:Adult; D017954:Africa South of the Sahara / Q000453:epidemiology; D000368:Aged; D018791:CD4 Lymphocyte Count; D002177:Candidiasis / Q000453:epidemiology; D015331:Cohort Studies; D004522:Educational Status; D005260:Female; D015658:HIV Infections / Q000453:epidemiology* / Q000635:transmission; D006801:Humans; D007843:Latin America / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D011020:Pneumonia, Pneumocystis / Q000453:epidemiology; D011446:Prospective Studies; D012307:Risk Factors; D012725:Sexual Behavior / Q000706:statistics & numerical data; D013030:Spain / Q000453:epidemiology; D015819:Substance Abuse, Intravenous / Q000453:epidemiology; D014376:Tuberculosis / Q000453:epidemiology