title: Study on self-assembly of gold nanoparticles directed by glutathione with resonance light scattering technique and its analytical applications.
abstract: In this paper, it has been demonstrated that gold nanoparticles can self-assemble to form network structure in the presence of glutathione, which results in great enhancement of resonance light scattering (RLS). Results from this RLS experiments confirm that RLS is a sensitive and convenient technique for studying the self-assembly of nanoparticles. The principles of the enhanced RLS of nanoparticle assemblies are discussed, and the mechanism of the interaction between gold nanoparticles and glutathione is investigated. The enhanced RLS of gold nanoparticle assemblies directed by glutathione is also successfully applied to sensitive determination of glutathione. Under the optimal conditions, the calibration curve for glutathione determination is linear in concentration range of 0.01-0.1 microg/ml, and the corresponding detection limit is 4.7 ng/ml (3sigma, 15.3 nM).
authors.affiliation: College of Chemistry and Environmental Science, Hebei University, Baoding 071002, Hebei Province, P R China.
authors.forename: Xin-Rui
authors.initials: XR
authors.lastname: Duan
authors.forename: Zheng-Ping
authors.initials: ZP
authors.lastname: Li
authors.forename: Peng-Juan
authors.initials: PJ
authors.lastname: Cui
authors.forename: Yu-Qin
authors.initials: YQ
authors.lastname: Su
mesh_terms: D015374:Biosensing Techniques / Q000379:methods*; D003460:Crystallization / Q000379:methods*; D005978:Glutathione / Q000032:analysis* / Q000737:chemistry*; D006046:Gold / Q000737:chemistry* / Q000528:radiation effects; D008027:Light; D046911:Macromolecular Substances / Q000737:chemistry; D008422:Materials Testing; D008968:Molecular Conformation; D049329:Nanostructures / Q000737:chemistry* / Q000528:radiation effects / Q000648:ultrastructure; D036103:Nanotechnology / Q000379:methods; D010316:Particle Size; D010777:Photochemistry / Q000379:methods*; D012542:Scattering, Radiation; D013499:Surface Properties
chemical_list: D046911:Macromolecular Substances; D006046:Gold; D005978:Glutathione