title: Effect of Sterol Inhibitors on the Incorporation of 14C-Isopentenyl Pyrophosphate into Artemisinin by a Cell-Free System from Artemisia annua Tissue Cultures and Plants.
abstract: A cell-free system from ARTEMISIA ANNUA L. shoot cultures and plants (shoots and roots) which is capable of incorporating (14)C-isopentenyl pyrophosphate ( (14)C-IPP) into artemisinin has been developed. The sterol inhibitors miconazole, AMO 1618, CCC, and MER 29 increased both the incorporation of (14)C-IPP into artemisinin by cell-free extracts and the production of artemisinin in shoot cultures of ARTEMISIA ANNUA.
authors.affiliation: Department of Biology, Kenyon College, Gambier, Ohio 43022, U.S.A.
authors.forename: G J
authors.initials: GJ
authors.lastname: Kudakasseril
authors.forename: L
authors.initials: L
authors.lastname: Lam
authors.forename: E J
authors.initials: EJ
authors.lastname: Staba