Colchicine use in children and adolescents with familial Mediterranean fever: literature review and consensus statement.
The daily application of colchicine is the standard therapy for prophylaxis of attacks and amyloid deposition in familial Mediterranean fever. However, because of many issues (eg, dosage, time of introduction, etc), no standardized treatment recommendations have been established. In this work we review the available literature on colchicine use with respect to its indication, efficacy, mode of application, and safety in children and adolescents with familial Mediterranean fever. On the basis of this analysis, a consensus statement on the application of colchicine in children and adolescents with familial Mediterranean fever was developed by caregivers from Germany, Austria, and Turkey.
Kallinich
Tilmann
T
Department of Pediatric Pneumology and Immunology, Charite-Universitätsmedizin Berlin, Campus Virchow-Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany. tilmann.kallinich@charite.de
Haffner
Dieter
D
Niehues
Tim
T
Huss
Kristina
K
Lainka
Elke
E
Neudorf
Ulrich
U
Schaefer
Christof
C
Stojanov
Silvia
S
Timmann
Christian
C
Keitzer
Rolf
R
Ozdogan
Huri
H
Ozen
Seza
S
D000293:Adolescent; D002648:Child; D003078:Colchicine / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D010505:Familial Mediterranean Fever / Q000188:drug therapy*; D006801:Humans
D003078:Colchicine