Role of type-specific neuron properties in a spinal cord motor network.
Recent recordings from spinal neurons in hatchling frog tadpoles allow their type-specific properties to be defined. Seven main types of neuron involved in the control of swimming have been characterized. To investigate the significance of type-specific properties, we build models of each neuron type and assemble them into a network using known connectivity between: sensory neurons, sensory pathway interneurons, central pattern generator (CPG) interneurons and motoneurons. A single stimulus to a sensory neuron initiates swimming where modelled neuronal and network activity parallels physiological activity. Substitution of firing properties between neuron types shows that those of excitatory CPG interneurons are critical for stable swimming. We suggest that type-specific neuronal properties can reflect the requirements for involvement in one particular network response (like swimming), but may also reflect the need to participate in more than one response (like swimming and slower struggling).
Sautois
Bart
B
Department of Applied Mathematics and Computer Science, Ghent University, Krijgslaan 281-S9, B-9000 Ghent, Belgium. bart.sautois@ugent.be
Soffe
Stephen R
SR
Li
Wen-Chang
WC
Roberts
Alan
A
D000818:Animals; D008959:Models, Neurological; D009046:Motor Neurons / Q000145:classification* / Q000502:physiology*; D009415:Nerve Net / Q000502:physiology*; D016571:Neural Networks, Computer; D013116:Spinal Cord / Q000166:cytology*