[The enigma of arrival: [corrected] the entrance of auto-immune T lymphocytes in central nervous tissues and of their attack against the myelin structures].
This paper describes the conditions under which autoimmune T cells enter the central nervous system to attack the local tissue. During a prodromal period preceding the onset of neurological disease, the CNS tissue is converted from its physiological immune-hostile state to an immune-friendly state. At the same time, in the peripheral immune system, activated autoimmune T cells undergo profound changes that allow them to enter through the blood-brain barrier and to finally interact with local autoantigen-presenting cells. Antigen recognition leads to T cell activation and the secretion of inflammatory mediators that are responsible for the development of the inflammatory lesions and the neurological deficits.
Wekerle
Hartmut
H
Max-Planck-Institut für Neurobiologie, Am Klopferspitz 18, 82152 Martinsried, Allemagne. hwekerle@neuro.mpg.de
D000818:Animals; D001324:Autoantigens / Q000276:immunology; D015551:Autoimmunity; D002490:Central Nervous System / Q000276:immunology*; D006801:Humans; D007249:Inflammation / Q000276:immunology; D009186:Myelin Sheath / Q000737:chemistry / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
D001324:Autoantigens