title: Monoclonal antibodies as therapeutic agents in oncology and antibody gene therapy.
abstract: Antibodies as therapeutic agents are mostly used in oncology, as illustrated by their applications in lymphoma, breast cancer or colorectal cancer. This review provides a brief historical sketch of the development of monoclonal antibodies for cancer treatment and summarizes the most significant clinical data for the best-established reagents to date. It also discusses strategies to improve the anti-tumor efficacy of antibody therapy, including antibody gene therapy and exploitation of bone marrow derived primary mesenchymal stem cells as the antibody gene transporter.
authors.affiliation: Transplantation Research Institute of Sun Yat-sen University, The Third Affiliated Hospital of Sun Yat-Sen University, 600 Tianhe Rd, Guangzhou 510630, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Zhang
authors.forename: Guihua
authors.initials: G
authors.lastname: Chen
authors.forename: Xinyuan
authors.initials: X
authors.lastname: Liu
authors.forename: Qijun
authors.initials: Q
authors.lastname: Qian
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000235:genetics / Q000627:therapeutic use*; D015316:Genetic Therapy; D006801:Humans; D009369:Neoplasms / Q000276:immunology* / Q000628:therapy*
chemical_list: D000911:Antibodies, Monoclonal