title: Systemic onset juvenile rheumatoid arthritis presenting with absence of B lymphocytes.
abstract: Juvenile rheumatoid arthritis (JRA) is a complex disease involving the interactions of several cell populations with different mediators. Herein, we report a five-year-old girl with systemic-onset JRA. At admission, peripheral blood flowcytometric analysis showed the percentages of CD19(+) and CD20(+) B cells were <1%. These values returned to normal on the tenth day of steroid treatment. This is the first report of JRA presented with absence of B lymphocytes in the literature and suggested that lymphocytes subset analysis could change with treatment in patients with JRA. Different clinical signs and symptoms reflecting aspects of JRA are critical for the etiology of the disease and to identify new strategies for treatment.
authors.affiliation: Departments of Pediatrics, Pediatric Immunology and Allergy Division, Selcuk University Meram Medical Faculty, Beyşehir Yolu, 42080 Konya, Turkey. hasibeartac@yahoo.com
authors.forename: Hasibe
authors.initials: H
authors.lastname: Artac
authors.forename: Hayrullah
authors.initials: H
authors.lastname: Alp
authors.forename: Sevgi
authors.initials: S
authors.lastname: Keles
authors.forename: Ismail
authors.initials: I
authors.lastname: Reisli
authors.forename: Recep
authors.initials: R
authors.lastname: Tunc
mesh_terms: D018501:Antirheumatic Agents / Q000627:therapeutic use; D001171:Arthritis, Juvenile / Q000097:blood* / Q000175:diagnosis* / Q000188:drug therapy; D001402:B-Lymphocytes / Q000145:classification / Q000187:drug effects / Q000276:immunology*; D002675:Child, Preschool; D004359:Drug Therapy, Combination; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007958:Leukocyte Count / Q000379:methods*; D008727:Methotrexate / Q000627:therapeutic use; D008775:Methylprednisolone / Q000627:therapeutic use
chemical_list: D018501:Antirheumatic Agents; D008775:Methylprednisolone; D008727:Methotrexate