Successful treatment of inflammatory linear verrucous epidermal nevus with tacrolimus and fluocinonide.
BACKGROUND
Inflammatory linear verrucous epidermal nevus (ILVEN) is a relatively rare disorder that is characterized by an early age at onset; severely pruritic linear papules and plaques; histologic features resembling spongiotic dermatitis, psoriasis, or lichenified dermatitis; and poor response to treatment.


OBJECTIVE
To report the successful treatment of ILVEN with potent topical steroid and tacrolimus ointments.


METHODS
An 11-year-old girl presented with a 1-year history of markedly pruritic, progressive linear eruption that extended from the right foot to the right buttock. She had failed treatment with pimecrolimus, calcipotriol, mometasone furoate, triamcinolone, tazarotene, and alpha-hydroxy acid. Histologic examination revealed the findings of spongiotic dermatitis.


RESULTS
The lesions resolved with fluocinonide ointment and tacrolimus 0.1% ointment.


CONCLUSIONS
The combination of two therapeutic agents with different mechanisms of action likely resulted in the successful treatment of this usually resistant condition.
Mutasim
Diya F
DF
Department of Dermatology, University of Cincinnati College of Medicine, Cincinnati, OH 45267-0592, USA. diya.mutasim@uc.edu
D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D002648:Child; D004359:Drug Therapy, Combination; D005260:Female; D005447:Fluocinonide / Q000627:therapeutic use*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D007866:Leg; D009506:Nevus / Q000188:drug therapy*; D012878:Skin Neoplasms / Q000188:drug therapy*; D016559:Tacrolimus / Q000627:therapeutic use*
D000893:Anti-Inflammatory Agents; D007166:Immunosuppressive Agents; D005447:Fluocinonide; D016559:Tacrolimus