title: Suppressive effect of partially hydrolyzed guar gum on transitory diarrhea induced by ingestion of maltitol and lactitol in healthy humans.
abstract: OBJECTIVE
  To estimate the suppressive effect of partially hydrolyzed guar gum (PHGG) on transitory diarrhea induced by ingestion of a sufficient amount of maltitol or lactitol in female subjects.
  
  
  METHODS
  The first, the minimal dose level of maltitol and lactitol that would induce transitory diarrhea was estimated separately for each subject. Individual subject was administered a dose that increased by 5 g stepwise from 10 to 45 g until diarrhea was experienced. Thereafter, the suppressive effect on diarrhea was observed after each subject ingested a mixture of 5 g of PHGG and the minimal dose level of maltitol or lactitol.
  
  
  METHODS
  Laboratory of Public Health Nutrition, Department of Nutrition and Health Sciences, Siebold University of Nagasaki.
  
  
  METHODS
  Thirty-four normal female subjects (21.3+/-0.9 years; 49.5+/-5.3 kg).
  
  
  METHODS
  Incidence of diarrhea caused by the ingestion of maltitol or lactitol and the ratio of suppression achieved by adding PHGG for diarrhea.
  
  
  RESULTS
  The ingestion of amounts up to 45 g of maltitol, diarrhea caused in 29 of 34 subjects (85.3%), whereas the ingestion of lactitol caused diarrhea in 100%. The diarrhea owing to maltitol was improved in 10 of 28 subjects by the addition of 5 g of PHGG to minimal dose-induced diarrhea, and that owing to lactitol was in seven of 19 subjects. Adding 10 g of PHGG strongly suppressed the diarrhea caused by maltitol, and the cumulative ratio was 82.1% (23/28).
  
  
  CONCLUSIONS
  The transitory diarrhea caused by the ingestion of maltitol or lactitol was clearly suppressed by the addition of PHGG. These results strongly suggest that diarrhea caused by the ingestion of a sufficient amount of non-digestible sugar substitute can be suppressed by the addition of dietary fiber.
authors.affiliation: Graduate School of Human Health Science, Siebold University of Nagasaki, Nagasaki, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Nakamura
authors.forename: R
authors.initials: R
authors.lastname: Hongo
authors.forename: K
authors.initials: K
authors.lastname: Moji
authors.forename: T
authors.initials: T
authors.lastname: Oku
mesh_terms: D000328:Adult; D002400:Cathartics / Q000008:administration & dosage / Q000009:adverse effects*; D003967:Diarrhea / Q000139:chemically induced / Q000188:drug therapy*; D004043:Dietary Fiber / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005685:Galactans / Q000627:therapeutic use*; D005769:Gastrointestinal Motility / Q000187:drug effects*; D006801:Humans; D008320:Maltose / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives; D008351:Mannans / Q000627:therapeutic use*; D053149:Plant Gums / Q000627:therapeutic use*; D013402:Sugar Alcohols / Q000008:administration & dosage / Q000009:adverse effects; D016896:Treatment Outcome
chemical_list: D002400:Cathartics; D004043:Dietary Fiber; D005685:Galactans; D008351:Mannans; D053149:Plant Gums; D013402:Sugar Alcohols; D008320:Maltose; C010745:maltitol; C007894:guar gum; C014635:lactitol