Cortical perfusion is an important factor, but not a determinant of increased vulnerability of immature to traumatic brain injury.
Traumatic brain injury is a major health problem worldwide and main reason of mortality and morbidity in children and young adolescents, meanwhile there is clinical evidence that TBI to children younger than 4 years of age has been shown to cause significantly more severe cognitive and motor deficits. The biologic factors that contribute to this vulnerability are not understood yet. In this work we are investigating the role of local cerebral perfusion disturbances and vascular proliferation in involvement of secondary injury and probable participation in age-dependent vulnerability. Similar patterns of perfusion changes in both age groups proves, that despite of high importance of cerebral blood flow in prognosis and outcomes, local perfusion is not of the determinants of increased vulnerability of immature to TBI.
Manvelyan
H
H
Yerevan State Medical University after M. Heratsi.
D000818:Animals; D001921:Brain / Q000098:blood supply*; D001930:Brain Injuries / Q000000981:diagnostic imaging / Q000503:physiopathology*; D002560:Cerebrovascular Circulation / Q000502:physiology; D017078:Laser-Doppler Flowmetry; D051379:Mice; D008810:Mice, Inbred C57BL; D013997:Time Factors; D014463:Ultrasonography