Serum adiponectin and renal dysfunction in men with type 2 diabetes.
OBJECTIVE
Inflammation is associated with both chronic kidney dysfunction and type 2 diabetes. Adiponectin, a novel circulating anti-inflammatory protein made by adipocytes, has been reported to be lower in diabetic than nondiabetic subjects. In contrast, serum levels of adiponectin are elevated in end-stage renal disease. We sought to investigate the relation between adiponectin and mild to moderate renal dysfunction in men with type 2 diabetes.


METHODS
Multivariate logistic regression was used to evaluate the relation between serum adiponectin concentrations and the presence of renal dysfunction (estimated glomerular filtration rate [eGFR] <60 ml/min per 1.73 m(2) by the four-variable Modification of Diet in Renal Disease equation) in participants with type 2 diabetes in the Health Professionals' Follow-Up Study. A total of 733 men were included in this cross-sectional analysis.


RESULTS
Adiponectin was positively correlated with age (Spearman coefficient, r = 0.19, P < 0.001) and negatively correlated with weight (Spearman coefficient, r = -0.18, P < 0.001). Those with adiponectin in the second quartile or higher (>10 microg/ml) compared with those in the first quartile had a reduced odds for renal dysfunction (multivariate odds ratio 0.48 [95% CI 0.28-0.81]). These results were unchanged when serum lipids were included in the multivariate model.


CONCLUSIONS
We conclude that a higher serum adiponectin concentration is associated with reduced odds of moderate renal dysfunction in men with type 2 diabetes.
Lin
Julie
J
Renal Division, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA. jlin11@partners.org
Hu
Frank B
FB
Curhan
Gary
G
D052242:Adiponectin / Q000097:blood*; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D001835:Body Weight; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology*; D003928:Diabetic Nephropathies / Q000097:blood*; D015444:Exercise; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012044:Regression Analysis; D012907:Smoking / Q000453:epidemiology
D052242:Adiponectin; D015415:Biomarkers