Rational design and synthesis of novel nucleotide anti-Giardia agents.
Design and synthesis of a novel nucleotide anti-Giardia agent that is micromolar inhibitor of Giardia trophozoite growth in culture is described.
Suk
Dae-Hwan
DH
Center for Drug Design, Academic Health Center, University of Minnesota, Minneapolis, MN 55455, USA.
Bonnac
Laurent
L
Dykstra
Christine C
CC
Pankiewicz
Krzysztof W
KW
Patterson
Steven E
SE
D000116:Acetylgalactosamine / Q000737:chemistry; D000818:Animals; D000981:Antiprotozoal Agents / Q000494:pharmacology*; D002236:Carbohydrate Conformation; D002240:Carbohydrate Sequence; D002473:Cell Wall / Q000187:drug effects; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D015195:Drug Design; D005872:Giardia / Q000378:metabolism*; D006801:Humans; D008956:Models, Chemical; D008969:Molecular Sequence Data; D009711:Nucleotides / Q000737:chemistry*; D053058:Trophozoites; D014867:Water / Q000737:chemistry
D000981:Antiprotozoal Agents; D009711:Nucleotides; D014867:Water; D000116:Acetylgalactosamine