Slow-releasing tranilast in polytetrafluoroethylene/polylactide-co-glycolide laminate delays adjustment after strabismus surgery in rabbit model.
OBJECTIVE
To determine the usefulness of slow-releasing tranilast in polytetrafluoroethylene/polylactide-co-glycolide (PTFE/PLGA) laminate for delayed adjustable strabismus surgery.


METHODS
A prospective, masked-observer, controlled study was performed in 25 rabbits. Fifty rabbit eyes were divided randomly into three groups. After a recession of the superior rectus muscle (SRM), a PTFE/PLGA laminate containing tranilast, PTFE alone, or balanced salt solution was applied beneath and over the SRM in the PTFE/PLGA-tranilast group (group P-T), the PTFE group (group P), and the control group, respectively. Delayed adjustment was performed by a masked observer once on each SRM 3 or 5 weeks after surgery. Adjustability, adjustment lengths, forces required, and adhesion degrees were evaluated.


RESULTS
In the control group, adjustment was impossible in any eye 3 or 5 weeks after surgery. In group P, adjustment was possible in 5 of 8 eyes 3 weeks after surgery and in 5 of 10 eyes 5 weeks after surgery. In group P-T, adjustment was possible in 8 of 10 eyes 3 and 5 weeks after surgery. On comparing adjustability, a significant difference was observed between group P-T and the control group 3 and 5 weeks after surgery (P = 0.006, P = 0.006, respectively). A significant difference was observed between group P-T and the control group (P = 0.016) in terms of adhesion between SRMs and conjunctivae 5 weeks after surgery.


CONCLUSIONS
Slow-releasing tranilast in PTFE/PLGA was found to reduce adhesion and allowed delayed adjustment in most eyes for up to 5 weeks after surgery.
Lee
Min Joung
MJ
Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Korea.
Jin
Su-Eon
SE
Kim
Chong-Kook
CK
Choung
Ho-Kyung
HK
Jeoung
Jin Wook
JW
Kim
Hwa Jung
HJ
Choe
Gheeyoung
G
Hwang
Jeong-Min
JM
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D019344:Lactic Acid; D023421:Models, Animal; D009801:Oculomotor Muscles / Q000187:drug effects / Q000473:pathology; D011100:Polyglycolic Acid; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011108:Polymers; D011138:Polytetrafluoroethylene; D011183:Postoperative Complications / Q000517:prevention & control*; D011446:Prospective Studies; D011817:Rabbits; D012590:Sclera / Q000187:drug effects / Q000473:pathology; D013285:Strabismus / Q000601:surgery*; D013536:Suture Techniques; D000267:Tissue Adhesions / Q000517:prevention & control; D062367:ortho-Aminobenzoates / Q000008:administration & dosage*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D011108:Polymers; D062367:ortho-Aminobenzoates; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D011138:Polytetrafluoroethylene; C012293:tranilast