Effects of reaction rate of radical anion of a photosensitizer with molecular oxygen on the photosensitized DNA damage.
Based on the synthesis of DNA modified with photosensitizers, direct spectroscopic measurements of the hole transfer in DNA, and quantification of the yield of the DNA oxidative damage, the reaction rate of the radical anion of the photosensitizer was demonstrated to be critically important in determining the efficiency of photosensitized DNA damage.
Kawai
Kiyohiko
K
The Institute of Scientific and Industrial Research (SANKEN), Osaka University, Mihogaoka 8-1, Ibaraki, Osaka 567-0047, Japan. kiyohiko@sanken.osaka-u.ac.jp
Osakada
Yasuko
Y
Fujitsuka
Mamoru
M
Majima
Tetsuro
T
D000838:Anions / Q000737:chemistry; D001483:Base Sequence; D004249:DNA Damage; D005609:Free Radicals / Q000737:chemistry*; D010084:Oxidation-Reduction; D010100:Oxygen / Q000737:chemistry*; D010777:Photochemistry; D017319:Photosensitizing Agents / Q000737:chemistry*; D013057:Spectrum Analysis
D000838:Anions; D005609:Free Radicals; D017319:Photosensitizing Agents; D010100:Oxygen