title: Can cell systems biology rescue drug discovery?
abstract: The focus of innovation in current drug discovery is on new targets, yet compound efficacy and safety in biological models of disease, not target selection, qualify drug candidates for the clinic. We consider a biology-driven approach to drug discovery based on screening compounds by automated response profiling in complex human cell systems-based disease models. Drug discovery through cell systems biology could significantly reduce the time and cost of new drug development.
authors.affiliation: Department of Pathology, Stanford University Medical Center, CA 94305-5324, USA. ebutcher@stanford.edu
authors.forename: E C
authors.initials: EC
authors.lastname: Butcher