Sex-related aspects on abnormal glucose regulation in patients with coronary artery disease.
OBJECTIVE
To investigate the prevalence of diabetes and impaired glucose regulation (IGR) in a large cohort of men and women with coronary artery disease (CAD), and to describe the effect of abnormal glucose regulation by sex on symptoms, clinical course, and diagnosis.


RESULTS
A total of 4855 patients with CAD (median age 66 years; 29% women) were analysed within the framework of the Euro Heart Survey on Diabetes and the Heart. In all, 967 (28.1%) men and 528 (37.5%) women had diabetes. Of 3185 patients with unknown glucose regulation, 1835 (57.6%; 1400 men and 435 women) underwent an oral glucose tolerance test revealing that 17% of the men and 18% of the women had diabetes and 35 and 39% impaired glucose tolerance or impaired fasting glucose, respectively. Thus, only 19% of the women and 27% of the men had a normal glucose regulation. Women were more likely to have diabetes than men with an odds ratio (OR) of 1.32 (1.13-1.54). The corresponding OR for abnormal glucose regulation was 1.34 (1.11-1.62). Gender did not influence differences in clinical presentation between patients with diabetes or IGR and those with a normal glucose metabolism.


CONCLUSIONS
Abnormal glucose regulation was more common in women than men with CAD. However, the influence of diabetes on presenting symptoms and clinical course was similar in men and women.
Dotevall
Annika
A
Department of Medicine, Sahlgrenska University Hospital/Ostra, S-416 85 Göteborg, Sweden. annika.dotevall@vgregion.se
Rosengren
Annika
A
Bartnik
Malgorzata
M
Malmberg
Klas
K
Ohrvik
John
J
Simoons
Maarten
M
Rydén
Lars
L
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001786:Blood Glucose / Q000378:metabolism*; D015992:Body Mass Index; D003324:Coronary Artery Disease / Q000097:blood* / Q000188:drug therapy; D003925:Diabetic Angiopathies / Q000097:blood / Q000188:drug therapy; D005260:Female; D018149:Glucose Intolerance / Q000378:metabolism*; D006760:Hospitalization; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012737:Sex Factors
D001786:Blood Glucose