title: Asymmetric hydrogenation of quinolines with high substrate/catalyst ratio.
abstract: The chiral diphosphinite ligand derived from (R)-1,1'-spirobiindane-7,7'-diol has been found to be highly effective in the Ir-catalyzed asymmetric hydrogenation of quinolines with high substrate/catalyst ratio (up to 5000) and high enantioselectivity (up to 94% ee).
authors.affiliation: Open Laboratory of Chirotechnology of the Institute of Molecular Technology for Drug Discovery and Synthesis and Department of Applied Biology and Chemical Technology, the Hong Kong Polytechnic University, Hong Kong, P. R. China.
authors.forename: Wei-Jun
authors.initials: WJ
authors.lastname: Tang
authors.forename: Shou-Fei
authors.initials: SF
authors.lastname: Zhu
authors.forename: Li-Jin
authors.initials: LJ
authors.lastname: Xu
authors.forename: Qi-Lin
authors.initials: QL
authors.lastname: Zhou
authors.forename: Qing-Hua
authors.initials: QH
authors.lastname: Fan
authors.forename: Hai-Feng
authors.initials: HF
authors.lastname: Zhou
authors.forename: Kimhung
authors.initials: K
authors.lastname: Lam
authors.forename: Albert S C
authors.initials: AS
authors.lastname: Chan