title: Formulation of ELF magnetic fields' effects on malondialdehyde level and myeloperoxidase activity in kidney using genetic programming.
abstract: In vivo exposure effects of electromagnetic fields (EMFs) on various tissues of experiment animals have been investigated. In this sense, modeling and formulation of these biological effects have been of significant importance. In this study extremely low frequency (ELF) EMFs effects on malondialdehyde (MDA) level and myeloperoxidase (MPO) activity in kidney of guinea pigs exposed to 50 Hz magnetic fields of 1 mT, 2 mT and 3 mT have been presented. It has been planned to determine whether genetic programming (GP) is appropriate to analyze and formulate these biological effects. Consequently, it has been observed that GP can be effectively used to model MDA level and MPO activity. The performances of prediction of the proposed GP formulation versus actual experimental values are found to be quite satisfactory in terms of standard deviation and correlation coefficient. It is concluded that the GP application serves to form a database for the researchers in this field, without exposing tissues to EMF and without using too many guinea pigs.
authors.affiliation: Electrical and Electronics Engineering, University of Gaziantep, 27310 Gaziantep, Turkey. g_tohumoglu@gantep.edu.tr
authors.forename: Gülay
authors.initials: G
authors.lastname: Tohumoglu
authors.forename: Ayşe G
authors.initials: AG
authors.lastname: Canseven
authors.forename: Abdulkadir
authors.initials: A
authors.lastname: Cevik
authors.forename: Nesrin
authors.initials: N
authors.lastname: Seyhan
mesh_terms: D000818:Animals; D004574:Electromagnetic Fields; D006168:Guinea Pigs; D007668:Kidney / Q000378:metabolism*; D008297:Male; D008315:Malondialdehyde / Q000032:analysis / Q000528:radiation effects*; D015233:Models, Statistical; D009195:Peroxidase / Q000378:metabolism / Q000528:radiation effects*; D011831:Radiation Genetics; D014421:Turkey
chemical_list: D008315:Malondialdehyde; D009195:Peroxidase