Glycotargeting to improve cellular delivery efficiency of nucleic acids.
Nucleic acids bearing glycans of various structures have been under vigorous investigation in the past decade. The carbohydrate moieties of such complexes can serve as recognition sites for carbohydrate-binding proteins-lectins-and initiate receptor-mediated endocytosis. Therefore, carbohydrates can enhance cell targeting and internalization of nucleic acids that are associated with them and thus improve the bioavailability of nucleic acids as therapeutic agents. This review summarizes nucleic acid glycosylation in nature and approaches for the preparation of both non-covalently associated and covalently-linked carbohydrate-nucleic acid complexes.
Yan
Hongbin
H
Department of Chemistry, Brock University, 500 Glenridge Ave., St. Catharines, ON, Canada. tyan@brocku.ca
Tram
Kha
K
D002240:Carbohydrate Sequence; D050091:Dendrimers / Q000008:administration & dosage / Q000138:chemical synthesis / Q000737:chemistry; D016503:Drug Delivery Systems / Q000379:methods*; D006001:Glycoconjugates / Q000008:administration & dosage / Q000138:chemical synthesis / Q000737:chemistry; D006031:Glycosylation; D007364:Intercalating Agents; D008969:Molecular Sequence Data; D015394:Molecular Structure; D009696:Nucleic Acids / Q000008:administration & dosage* / Q000138:chemical synthesis / Q000737:chemistry*; D010084:Oxidation-Reduction; D011073:Polyamines / Q000008:administration & dosage / Q000138:chemical synthesis / Q000737:chemistry; D011107:Polylysine / Q000008:administration & dosage / Q000138:chemical synthesis / Q000737:chemistry
D050091:Dendrimers; D006001:Glycoconjugates; D007364:Intercalating Agents; D009696:Nucleic Acids; D011073:Polyamines; D011107:Polylysine