C-Alkyl 5-membered ring imino sugars as new potent cytotoxic glucosylceramide synthase inhibitors.
The stereoselective preparation of novel C-alkyl 5-membered ring imino sugars and their biological evaluation with regard to GCS inhibition and cytotoxicity in a murine melanoma model are reported.
Faugeroux
Vanessa
V
Laboratoire de Synthèse et Physicochimie de Molécules d'Intérêt Biologique, UMR 5068CNRS/Université Paul Sabatier, 118 route de Narbonne, 31062, Toulouse Cedex 9, France.
Génisson
Yves
Y
Andrieu-Abadie
Nathalie
N
Colié
Sandra
S
Levade
Thierry
T
Baltas
Michel
M
D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D005964:Glucosyltransferases / Q000037:antagonists & inhibitors*; D006801:Humans; D050111:Imino Sugars / Q000737:chemistry* / Q000494:pharmacology*; D015394:Molecular Structure; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; D050111:Imino Sugars; D005964:Glucosyltransferases; C023246:ceramide glucosyltransferase