title: MR-guided intervention in women at high hereditary risk of breast cancer due to both family and personal history of breast cancer.
abstract: The purpose of this study was to assess the value of magnetic resonance imaging (MRI)-guided intervention in women with a significant hereditary susceptibility to breast cancer due to both family and personal history of breast cancer (heterozygote risk >20%). Thirty women were referred for MR-guided intervention. MR examinations (1.0 T, T1-weighted 3D FLASH, 0.15 mmol Gd-DTPA/kg body weight, prone position) were performed using a system which allows vacuum-assisted breast biopsy or wire localization. Histologic findings in 41 procedures revealed six invasive carcinomas, eight ductal carcinomas in situ and two atypical ductal hyperplasias. Twenty-three benign histologic results were verified by an MR-guided intervention, retrospective correlation of imaging and histology and by subsequent follow-up. In two lesions the indication dropped as the enhancing lesion was no longer visible on the date of planned intervention. Absent enhancement was confirmed by short-term re-imaging of the non-compressed breast and by follow-up.
authors.affiliation: Institute of Diagnostic Radiology, Technical University Dresden, Dresden, Germany. petra.viehweg@uniklinikum-dresden.de
authors.forename: Petra
authors.initials: P
authors.lastname: Viehweg
authors.forename: Thorsten
authors.initials: T
authors.lastname: Bernerth
authors.forename: Anke
authors.initials: A
authors.lastname: Heinig
authors.forename: Marion
authors.initials: M
authors.lastname: Kiechle
authors.forename: Jörg
authors.initials: J
authors.lastname: Buchmann
authors.forename: Heinz
authors.initials: H
authors.lastname: Koelbl
authors.forename: Michael
authors.initials: M
authors.lastname: Laniado
authors.forename: Sylvia
authors.initials: S
authors.lastname: Helen Heywang-Köbrunner
mesh_terms: D000328:Adult; D000368:Aged; D001707:Biopsy, Needle; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D006579:Heterozygote; D006801:Humans; D053783:Magnetic Resonance Imaging, Interventional; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D011237:Predictive Value of Tests