[Metabolic syndrome and small dense LDL].
Due to the recent westernization of our lifestyle, it is speculated that the prevalence of metabolic syndrome in the young generation will increase in Japan. Different from Western populations, because of our lifestyle as "farmers" from ancient times, excess energy has been stored outside of the body, and the accumulation of visceral fat might have serious adverse effects on glucose and lipid metabolism. Therefore, we must carefully diagnose and treat patients with metabolic syndrome, which is diagnosed based on the existence of visceral obesity. On the other hand, much attention has been paid recently to the atherogenicity of small dense LDL. In this chapter I will introduce a newly established method for estimating the plasma concentration of small dense LDL-cholesterol. Furthermore, the relationship between subclinical atherosclerosis and small dense LDL in metabolic syndrome will be discussed.
Yoshino
Gen
G
Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Toho University School of Medicine, Ota-ku, Tokyo.
D050197:Atherosclerosis / Q000209:etiology; D008078:Cholesterol, LDL / Q000097:blood* / Q000502:physiology; D003327:Coronary Disease / Q000209:etiology; D006801:Humans; D006973:Hypertension / Q000209:etiology; D007333:Insulin Resistance; D050152:Intra-Abdominal Fat; D024821:Metabolic Syndrome / Q000209:etiology*; D009765:Obesity / Q000209:etiology; D010316:Particle Size; D012307:Risk Factors
D008078:Cholesterol, LDL