title: Synthesis, characterization and biological activity of complexes of 2-hydroxy-3,5-dimethylacetophenoneoxime (HDMAOX) with copper(II), cobalt(II), nickel(II) and palladium(II).
abstract: A new series of complexes of 2-hydroxy-3,5-dimethyl acetophenone oxime (HDMAOX) with Cu(II), Co(II), Ni(II) and Pd(II) have been prepared and characterized by different physical techniques. Infrared spectra of the complexes indicate deprotonation and coordination of the phenolic OH. It also confirms that nitrogen atom of the oximino group contributes to the complexation. Electronic spectra and magnetic susceptibility measurements reveal square planar geometry for Cu(II), Ni(II) and Pd(II) complexes and tetrahedral geometry for Co(II) complex. The elemental analyses and mass spectral data have justified the ML(2) composition of complexes. Kinetic and thermodynamic parameters were computed from the thermal decomposition data using Coats and Redfern method. The geometry of the metal complexes has been optimized with the help of molecular modeling. The free ligand (HDMAOX) and its metal complexes have been tested in vitro against Alternarie alternate, Aspergillus flavus, Aspergillus nidulans and Aspergillus niger fungi and Streptococcus, Staph, Staphylococcus and Escherchia coli bacteria in order to assess their antimicrobial potential. The results indicate that the ligand and its metal complexes possess antimicrobial properties.
authors.affiliation: Department of Chemistry, University of Delhi, Delhi 110007, India.
authors.forename: Bibhesh K
authors.initials: BK
authors.lastname: Singh
authors.forename: Umesh K
authors.initials: UK
authors.lastname: Jetley
authors.forename: Rakesh K
authors.initials: RK
authors.lastname: Sharma
authors.forename: Bhagwan S
authors.initials: BS
authors.lastname: Garg
mesh_terms: D000098:Acetophenones / Q000032:analysis* / Q000737:chemistry*; D000890:Anti-Infective Agents / Q000494:pharmacology; D000935:Antifungal Agents / Q000494:pharmacology; D003035:Cobalt / Q000032:analysis*; D003300:Copper / Q000032:analysis*; D004581:Electronics; D007700:Kinetics; D008826:Microbial Sensitivity Tests / Q000379:methods*; D008956:Models, Chemical; D008968:Molecular Conformation; D009532:Nickel / Q000032:analysis*; D010091:Oximes / Q000032:analysis* / Q000737:chemistry*; D010165:Palladium / Q000032:analysis*; D013053:Spectrophotometry / Q000379:methods; D013055:Spectrophotometry, Infrared / Q000379:methods; D013816:Thermodynamics
chemical_list: C524451:2-hydroxy-3,5-dimethylacetophenoneoxime; D000098:Acetophenones; D000890:Anti-Infective Agents; D000935:Antifungal Agents; D010091:Oximes; D003035:Cobalt; D010165:Palladium; D003300:Copper; D009532:Nickel