title: Use of antibiotics in the poultry industry in Saudi Arabia: implications for public health.
abstract: BACKGROUND
  The use of antimicrobial agents in food-producing animals has become an important public health issue due to the spread of microbial resistance. This study was aimed at identifying the antimicrobial agents available for poultry use and highlighting their possible impact on public health.
  
  
  METHODS
  Twenty-three randomly selected poultry farms and all veterinary pharmacies in the Eastern Province of Saudi Arabia were surveyed for the antibiotics used or dispensed. Further, a comprehensive literature survey was performed.
  
  
  RESULTS
  Twenty-nine antimicrobial agents were identified as being available for poultry use, of which 22 (75.9%) were important for the treatment of human infections. Enrofloxacin, oxytetracycline, ampicillin, neomycin, sulphamethoxazole, colistin, doxycycline and erythromycin were the most frequently used drugs. Food-borne hypersensitivity reactions and the emergence of microbial resistance, as well as cross-resistance to the various groups of antibiotics in animals and its transfer to human pathogens, are well documented.
  
  
  CONCLUSIONS
  The misuse of antibiotics in the local poultry industry poses a serious health risk to the public and may complicate the treatment of human infections. The veterinary use of antimicrobial agents, especially those with dual animal and human applications, should therefore be restricted. The establishment of a government department concerned with food and drug safety is also highly recommended.
authors.affiliation: Department of Pharmacology, College of Medicine, King Faisal University, Dammam, Saudi Arabia.
authors.forename: Zaki H
authors.initials: ZH
authors.lastname: Al-Mustafa
authors.forename: Mastour S
authors.initials: MS
authors.lastname: Al-Ghamdi