Life without kinase: cyclin E promotes DNA replication licensing and beyond.
In a recent issue of Molecular Cell, Sicinski and colleagues report the surprising discovery that cyclin E promotes replication licensing and transformation independently of CDKs, resolving inconsistencies of inactivating cyclin E and CDK2 in the mouse and cells.
Zhang
Hui
H
Department of Genetics, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA. hui.zhang@yale.edu
D000818:Animals; D019927:Cyclin E / Q000172:deficiency / Q000235:genetics / Q000378:metabolism*; D051357:Cyclin-Dependent Kinase 2 / Q000172:deficiency / Q000235:genetics / Q000378:metabolism; D004261:DNA Replication; D051379:Mice; D018345:Mice, Knockout; D008954:Models, Biological
D019927:Cyclin E; C495893:Cdk2 protein, mouse; D051357:Cyclin-Dependent Kinase 2