Induction of Mutations by gamma-Rays in Pregonial Germ Cells of Zebrafish Embryos.
Specific locus (gol-1) germ line mutations are induced by gamma-rays with high frequencies (about 10(-5) r( -1)) during cleavage divisions in zebrafish. Mutant clone sizes range from 3 to 50% of the total number of germ cells, with a mean of about 10%, when embryos are exposed between the 16 and 10(3) cell stages. About five pregonial cells are calculated to be present during the cleavage period.
Walker
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Institute of Molecular Biology, University of Oregon, Eugene, Oregon 97403.
Streisinger
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