Phototransformation products of tamoxifen by sunlight in water. Toxicity of the drug and its derivatives on aquatic organisms.
Transformation of tamoxifen has been observed in water by prolonged sunlight irradiation. The main photoproducts, isolated by chromatographic techniques, have been identified by spectroscopic means. Photoisomerization, photocyclization and, to a lesser extent, photooxygenation appear to be involved in the degradation of the drug. The acute and chronic toxicity of the parent drug and its photoproducts were tested on non-target aquatic organisms (Brachionus calyciflorus, Thamnocephalus platyurus, Daphnia magna and Ceriodaphnia dubia). Exposure to all the compounds induced mainly chronic effects without significant differences among the parental and derivative compounds.
DellaGreca
Marina
M
Dipartimento di Chimica Organica e Biochimica, Università di Napoli Federico II, Complesso Universitario Monte Sant'Angelo, Via Cinthia 4, I-80126 Napoli, Italy.
Iesce
Maria Rosaria
MR
Isidori
Marina
M
Nardelli
Angela
A
Previtera
Lucio
L
Rubino
Maria
M
D000818:Animals; D003445:Crustacea / Q000187:drug effects*; D003500:Cyclization; D007536:Isomerism; D007928:Lethal Dose 50; D008956:Models, Chemical; D015394:Molecular Structure; D010084:Oxidation-Reduction; D010777:Photochemistry; D012403:Rotifera / Q000187:drug effects*; D013472:Sunlight; D013629:Tamoxifen / Q000737:chemistry / Q000528:radiation effects / Q000633:toxicity; D014874:Water Pollutants, Chemical / Q000737:chemistry / Q000528:radiation effects / Q000633:toxicity
D014874:Water Pollutants, Chemical; D013629:Tamoxifen