Highly enantioselective nitroaldol reaction catalyzed by new chiral copper complexes.
Remarkable generality in scope of DATs/Cu catalysts for enantioselective nitroaldol reaction is described; excellent levels of stereoinduction are recorded for a range of aldehydes (ee 81-99%, 17 examples) and the possibility to employ the present catalytic system as the key step for the preparation of highly functionalized tetrahydro-isoquinolines is demonstrated.
Bandini
Marco
M
Dipartimento di Chimica G. Ciamician, Università di Bologna, Via Selmi 2, 40126, Bologna, Italy. marco.bandini@unibo.it
Piccinelli
Fabio
F
Tommasi
Simona
S
Umani-Ronchi
Achille
A
Ventrici
Caterina
C