Split personality of transcription factors inside and outside the nuclear border.
Growing evidence indicates that transcription factors may have functions entirely distinct from the regulation of gene transcription. Here we describe three transcription factors that, when outside the nucleus, regulate calcium homeostasis by three independent but convergent mechanisms.
Naranjo
José R
JR
Centro Nacional de Biotecnología, Consejo Superior de Investigaciones Cientificas, Madrid, Spain. naranjo@cnb.uam.es
Mellström
Britt
B
D002118:Calcium / Q000378:metabolism*; D002467:Cell Nucleus / Q000378:metabolism*; D006801:Humans; D008954:Models, Biological; D024642:Potassium Channels, Voltage-Gated / Q000378:metabolism* / Q000502:physiology; D021381:Protein Transport; D015398:Signal Transduction; D014157:Transcription Factors / Q000378:metabolism* / Q000502:physiology; D019473:Transcription Factors, TFII / Q000378:metabolism* / Q000502:physiology
C104259:GTF2I protein, human; D024642:Potassium Channels, Voltage-Gated; D014157:Transcription Factors; D019473:Transcription Factors, TFII; D002118:Calcium