Inherited corneal opacifications with an unusual distribution.
OBJECTIVE
To describe corneal opacities of a new type and distribution in a small family.


METHODS
Family members were interviewed and examined to establish a pedigree and to detect any corneal abnormalities.


RESULTS
Two family members presented with corneal opacities. Both had, in the very peripheral cornea, flat, greyish, rounded opacities, 20-200 microm in diameter, on the Descemet's membrane. In addition, the mother had the same type of opacities over the central cornea just inside the Bowman's layer. The remaining parts of the corneas were clear. Vision was unaffected and the opacities caused no discomfort. There was no other corneal pathology. The subjects' general health was good.


CONCLUSIONS
To our knowledge, these types and distribution of corneal opacities have not been described previously. Although the mode of inheritance at this point is uncertain, we believe the changes are of a dystrophic nature.
Fagerholm
Per
P
Department of Ophthalmology, Linköping University Hospital, Linköping, Sweden. perfa@inr.liu.se
Dellby
Anette
A
Bäckman
Lennart
L
D000328:Adult; D003318:Corneal Opacity / Q000175:diagnosis / Q000235:genetics*; D003886:Descemet Membrane / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010375:Pedigree