Recent approaches towards the asymmetric synthesis of alpha,alpha-disubstituted alpha-amino acids.
The class of alpha,alpha-disubstituted alpha-amino acids has gained considerable attention in the past decades and continues doing so. The ongoing interest in biological and chemical properties of the substance class has inspired the development of many new methodologies for their asymmetric construction, which have not found their way into the general focus of organic chemistry yet. The aim of this review is to provide an overview of the developments in the field since 1998.
Vogt
Henning
H
Center for Sustainable and Green Chemistry, Department of Chemistry, Building 201, Technical University of Denmark, DK-2800, Lyngby, Denmark.
Bräse
Stefan
S
D000478:Alkylation; D000577:Amides / Q000737:chemistry; D000596:Amino Acids / Q000138:chemical synthesis*; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques / Q000379:methods* / Q000639:trends; D007094:Imides / Q000737:chemistry; D008956:Models, Chemical; D018716:Molecular Mimicry; D010455:Peptides / Q000138:chemical synthesis*; D011487:Protein Conformation; D013237:Stereoisomerism
D000577:Amides; D000596:Amino Acids; D007094:Imides; D010455:Peptides