title: [Synthesis and antithrombotic activity of acetylsalicyl ferulic acid-coupling furoxans and nitrates].
abstract: OBJECTIVE
  To synthesize and study the antithrombotic activity of NO-donating aspirin derivatives.
  
  
  METHODS
  Furoxans and nitrates were incorporated to aspirin via antioxidant ferulic acid as a linker, and the target compounds were screened for in vitro and in vivo inhibitory activities of platelet aggregation, and for inhibitory effect on A-V hypass thromhosis in rats.
  
  
  RESULTS
  Fourteen novel compounds I(1-14), were synthesized and their structures were confirmed Iy MS, IR, 1H NMR and elemental analysis. Biological screening results demonstrated that some tested compounds exhibited potential antithrombotic activ it.
  
  
  CONCLUSIONS
  Acetylsalicyl ferulic acid-coupling furoxans and nitrates might he used as a lead for further study.
authors.affiliation: Center of Drug Discovery, China Pharmaceutical University, Nanjing 210009, China.
authors.forename: Zhou
authors.initials: Z
authors.lastname: Zhou
authors.forename: Li-yuan
authors.initials: LY
authors.lastname: Jiang
authors.forename: Yi-hua
authors.initials: YH
authors.lastname: Zhang
authors.forename: Hui
authors.initials: H
authors.lastname: Ji
authors.forename: Yi
authors.initials: Y
authors.lastname: Sun
authors.forename: Si-xun
authors.initials: SX
authors.lastname: Peng
mesh_terms: D000818:Animals; D001241:Aspirin / Q000737:chemistry*; D003373:Coumaric Acids / Q000737:chemistry*; D005343:Fibrinolytic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D008956:Models, Chemical; D015394:Molecular Structure; D009566:Nitrates / Q000737:chemistry*; D020030:Nitric Oxide Donors / Q000737:chemistry; D010069:Oxadiazoles / Q000737:chemistry*; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D051381:Rats
chemical_list: D003373:Coumaric Acids; D005343:Fibrinolytic Agents; D009566:Nitrates; D020030:Nitric Oxide Donors; D010069:Oxadiazoles; D010975:Platelet Aggregation Inhibitors; C010166:furoxans; C004999:ferulic acid; D001241:Aspirin