Seminal vesicle protein IV and its derived active peptides: a possible physiological role in seminal clotting.
Seminal vesicle protein 4 (SV-IV) is a highly flexible molecule that in aqueous solution behaves as a concentration-dependent self-associating system in which the degree of association (monomer <--> dimer <--> trimer equilibrium) seems to be related to its biological activities. This review reports the functional role of SV-IV in seminal clotting exerted through the modulation of inflammation, hemostasis, and sperm protection against the damage induced by immunological or reactive oxygen species during the long journey of spermatozoa in the female genital tract.
Metafora
Salvatore
S
CNR, Institute of Genetics and Biophysics Adriano Buzzati-Traverso, Naples, Italy.
Esposito
Carla
C
Caputo
Ivana
I
Lepretti
Marilena
M
Cassese
Diana
D
Dicitore
Alessandra
A
Ferranti
Pasquale
P
Stiuso
Paola
P
D000818:Animals; D005260:Female; D006487:Hemostasis / Q000276:immunology; D006801:Humans; D007249:Inflammation / Q000276:immunology / Q000378:metabolism; D008297:Male; D010455:Peptides / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D011487:Protein Conformation; D017382:Reactive Oxygen Species / Q000276:immunology / Q000378:metabolism; D012661:Semen / Q000737:chemistry / Q000276:immunology* / Q000378:metabolism; D029607:Seminal Vesicle Secretory Proteins / Q000737:chemistry / Q000276:immunology* / Q000378:metabolism; D013094:Spermatozoa / Q000276:immunology / Q000378:metabolism; D013329:Structure-Activity Relationship
D010455:Peptides; D017382:Reactive Oxygen Species; D029607:Seminal Vesicle Secretory Proteins