Indole alkaloids from three species of the Ervatamia genus: E. officinalis, E. divaricata, and E. divaricata Gouyahua.
Six new indole alkaloids, 14,15-didehydro-10,11-dimethoxy-16-epivincamine (1), 14,15-didehydro-10-hydroxy-11-methoxy-16-epivincamine (2), 14,15-didehydro-10,11-dimethoxyvincamine (3), 14,15-didehydro-10-hydroxy-11-methoxyvincamine (4), 19,20-didehydro-6alpha-hydroxyervatamine (5), and dehydroxyervataminol (6), along with 36 known indole alkaloids, were isolated from three species, E. officinalis, E. divaricata, and E. divaricata Gouyahua, of the Ervatamia genus. The structures of these alkaloids were characterized on the basis of spectroscopic methods and chemical correlation. The in vitro cytotoxic activities of all the alkaloids except 7, 18, 27, 38, 40, and 44 against the tumor cell lines P-388 murine leukemia and A-549 human lung carcinoma were evaluated. Only the dimeric indole alkaloids showed cytotoxic activities.
Zhang
Hua
H
State Key Laboratory of Drug Research, Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, People's Republic of China.
Wang
Xiao-Ning
XN
Lin
Li-Ping
LP
Ding
Jian
J
Yue
Jian-Min
JM
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D029062:Apocynaceae / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D026121:Indole Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007941:Leukemia P388; D051379:Mice; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*
D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D026121:Indole Alkaloids