title: Salvage cryosurgery for recurrent prostate carcinoma after radiotherapy.
abstract: Cryotherapy is a salvage treatment for patients with biopsy-proved prostatic adenocarcinoma recurrent after radiotherapy. Proper sampling, labeling, and analysis of prostate biopsies allows prompt diagnosis, identification of important prognostic parameters, and planning of an appropriate therapeutic strategy. Whereas androgen-suppressive therapy is associated with only a temporary benefit, transperineal salvage cryosurgery offers a potentially curative option for patients with localized disease, even those with significant comorbidities. Technological advances, including computerized treatment planning and miniaturized cryoprobes, may provide further therapeutic advantages and lower complication rates. Cryotherapy should be included among the established therapeutic options for recurrence after radiotherapy.
authors.affiliation: Department of Urology, Polytechnic University of Marche Region, AOU Ospedali Riuniti, Ancona, Italy. galosiab@yahoo.it
authors.forename: Andrea B
authors.initials: AB
authors.lastname: Galosi
authors.forename: Franco
authors.initials: F
authors.lastname: Lugnani
authors.forename: Giovanni
authors.initials: G
authors.lastname: Muzzonigro
mesh_terms: D003452:Cryosurgery / Q000009:adverse effects; D006801:Humans; D008297:Male; D009367:Neoplasm Staging; D018579:Patient Selection; D011471:Prostatic Neoplasms / Q000473:pathology / Q000517:prevention & control / Q000532:radiotherapy* / Q000601:surgery*; D012008:Recurrence; D016879:Salvage Therapy