Disseminated tuberculosis with multiple intracerebral tuberculomas in a patient with anorexia nervosa.
OBJECTIVE
Multiple tuberculous mycobacterial infections infrequently occur in immunocompromised patients. The malnutrition resulted from anorexia nervosa may contribute to the significant impairment of immunity. The authors present a 23-year-old female patient initially diagnosed with anorexia nervosa.


METHODS
Immunological study revealed that helper T-cell (CD4) and cytotoxic T-cell (CD8) comprised 25 and 32%, respectively, with a CD4 to CD8 ratio of 0.78. Brain magnetic resonance imaging revealed various multiple rings enhancing lesions with edematous change in both cerebral and cerebellar hemispheres.


RESULTS
Open biopsy disclosed palisading epithelioid granuloma surrounded by inflamed granulation tissue. After anti-tuberculous therapy for 12 months, her weight was completely restored, but multiple intracranial tuberculomas were not completely disappeared.


CONCLUSIONS
Disseminated tuberculous mycobacterial infections including multiple intracranial tuberculomas may be attributed to immunocompromised status in anorexia nervosa.
Ahn
Jung Yong
JY
Department of Neurosurgery, Yonsei University College of Medicine, Seoul, South Korea. jyahn@yumc.yonsei.ac.kr
Chang
Jong Hee
JH
Kim
Keun Su
KS
Kim
Won Joo
WJ
D000328:Adult; D000856:Anorexia Nervosa / Q000150:complications / Q000175:diagnosis / Q000276:immunology*; D005260:Female; D006801:Humans; D016867:Immunocompromised Host; D008279:Magnetic Resonance Imaging; D016862:Tuberculoma, Intracranial / Q000150:complications / Q000175:diagnosis / Q000276:immunology* / Q000628:therapy; D014376:Tuberculosis / Q000150:complications / Q000175:diagnosis / Q000276:immunology* / Q000628:therapy