title: [Treatment of hydatid cyst in sheep. Assay of a new scolicide].
abstract: OBJECTIVE
  The main of this study was to show the rapidity of the protoscolicide action of a synthetic compound, dipeptide methyl ester when it is injected under echographic control into hydatid cyst of sheep.
  
  
  METHODS
  Fourthty sheep with hydatid cysts, repaired at echography and punctionable are treated by dipeptide methyl ester injection at the dose of 110 mM.
  
  
  RESULTS
  In vitro tests have allowed to define the efficacy dose of dipeptide methyl ester which is 110 mM. At echography, after injection of the drug, from the first minutes, a detachment of the inner membrane, a diminution of the size of the treated cyst were observed. The cyst content is modified. The sheep autopsy was realized after 4.6.12 and 17 weeks after the injection and showed a size reduction, a treated cyst calcification.
  
  
  CONCLUSIONS
  The dipeptide methyl ester injection into hydatid cyst induces rapidly a morphological alteration, they are calcified. The advantage of this compound is its very rapidity action, this could decrease dissemination risks of hydatid liquid in the organism during operation. Also, this drug permits to reduce the operation time.
authors.affiliation: Département de Radiologie, Hôpital d'Enfants, Bab Saâdoun, Tunis, Tunisie.
authors.forename: Azza
authors.initials: A
authors.lastname: Hammou
authors.forename: Marie-Elisabeth
authors.initials: ME
authors.lastname: Sarciron
authors.forename: Samia
authors.initials: S
authors.lastname: Lahmar
authors.forename: Férid
authors.initials: F
authors.lastname: Ben Chehida
authors.forename: Arnaud
authors.initials: A
authors.lastname: Ghérardi
authors.forename: Jamil
authors.initials: J
authors.lastname: Lahmar
authors.forename: A Gharbi
authors.initials: AG
authors.lastname: Hassen
authors.forename: Anne-Françoise
authors.initials: AF
authors.lastname: Pétavy
mesh_terms: D000818:Animals; D004151:Dipeptides / Q000494:pharmacology*; D004443:Echinococcosis / Q000000981:diagnostic imaging / Q000188:drug therapy*; D007267:Injections; D012756:Sheep; D018084:Ultrasonography, Interventional
chemical_list: D004151:Dipeptides