title: [Pulmonary nocardiosis with trimethoprime/sulphamethoxazole-resistant Nocardia paucivorans in a patient with no signs of immunosuppression].
abstract: This is so far the first published case report of a Nocardia paucivorans infection in an immunocompetent patient. A 54-year-old farmer was hospitalised with a history of coughing and fever for a period of five months. There was no indicator of either primary of secondary immunodeficiency in the prior medical history. A chest X-ray showed pneumonic infiltrates in the right middle und lower lobes, which progressed despite of antibiotic therapy with macrolides. A transbronchial biopsy revealed unspecific granulomatous inflammation of soft tissues. N. paucivorans - grew in cultures of sputum, bronchoalveolar lavage, and transbronchial biopsy. Oral antibiotic therapy was started with trimethoprime-sulphamethoxazole (TMP/SMX) and amoxicillin plus clavulanic acid. Susceptibility testing revealed high level resistance to TMP/SMX, which was consequently replaced by ciprofloxacin. Six months later, infiltrates had completely resolved and the patient did not report any residual clinical symptoms. The present case showed once again that nocardiosis is not limited to patients with immunodeficiencies. However, conservative combination therapy with oral antibiotics seems to be sufficiently effective for nocardiosis in the immunocompetent patient. For cases of suspected nocardiosis, a step-wise, risk-based diagnostic and therapeutic procedure is proposed.
authors.affiliation: Die Institutsangaben sind am Ende des Beitrags gelistet.
authors.forename: S
authors.initials: S
authors.lastname: Wegerle
authors.forename: A
authors.initials: A
authors.lastname: Markus
authors.forename: N
authors.initials: N
authors.lastname: Weber
authors.forename: H
authors.initials: H
authors.lastname: Steffen
authors.forename: B
authors.initials: B
authors.lastname: King
authors.forename: W
authors.initials: W
authors.lastname: Eder
authors.forename: E
authors.initials: E
authors.lastname: Philipp
authors.forename: A
authors.initials: A
authors.lastname: Morresi-Hauff
authors.forename: K
authors.initials: K
authors.lastname: Häussinger
authors.forename: H
authors.initials: H
authors.lastname: Hoffmann
mesh_terms: D019980:Amoxicillin-Potassium Clavulanate Combination / Q000627:therapeutic use; D002939:Ciprofloxacin / Q000627:therapeutic use; D024881:Drug Resistance, Bacterial; D004359:Drug Therapy, Combination; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D009615:Nocardia / Q000187:drug effects*; D009617:Nocardia Infections / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology; D018410:Pneumonia, Bacterial / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000627:therapeutic use*
chemical_list: D002939:Ciprofloxacin; D019980:Amoxicillin-Potassium Clavulanate Combination; D015662:Trimethoprim, Sulfamethoxazole Drug Combination