title: Copper-catalyzed multicomponent cascade process for the synthesis of hexahydro-1H-isoindolones.
abstract: Copper-catalyzed coupling of imines, dienylstannanes, and acryloyl chlorides followed by a Diels-Alder reaction afforded hexahydro-1H-isoindolones. Diversification of the core via Pd-catalyzed cross-coupling defines a new modular approach to isoindolone combinatorial libraries.
authors.affiliation: Department of Chemistry, University of Kansas, 1251 Wescoe Hall Drive, Lawrence, KS 66045, USA.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.forename: Helena C
authors.initials: HC
authors.lastname: Malinakova
mesh_terms: D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D007211:Indoles / Q000138:chemical synthesis*; D015394:Molecular Structure
chemical_list: D007211:Indoles; D003300:Copper