An efficient one-pot asymmetric synthesis of biaryl compounds via Diels-Alder/retro-Diels-Alder cascade reactions.
[reaction: see text] A single-step chirality transfer method for the synthesis of axially chiral biaryl compounds by construction of the second aromatic ring via a Diels-Alder/retro-Diels-Alder cascade reaction is reported. This methodology should find broad application in the synthesis of natural products and asymmetric catalysts.
Liu
Yongxiang
Y
Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education and Beijing National Laboratory for Molecular Science (BNLMS), College of Chemistry, Laboratory of Chemical Genomics, Shenzhen Graduate School, China.
Lu
Kui
K
Dai
Mingji
M
Wang
Kai
K
Wu
Wanqing
W
Chen
Jiahua
J
Quan
Junmin
J
Yang
Zhen
Z
D008958:Models, Molecular; D015394:Molecular Structure; D009930:Organic Chemicals / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
D009930:Organic Chemicals