title: Chemoinformetrical evaluation of dissolution property of indomethacin tablets by near-infrared spectroscopy.
abstract: OBJECTIVE
  The purpose of this study was to use near-infrared spectrometry (NIR) with chemoinformetrics to predict the change of dissolution properties in indomethacin (IMC) tablets during the manufacturing process. A comparative evaluation of the dissolution properties of the tablets was performed by the diffused reflectance (DRNIR) and transmittance (TNIR) NIR spectroscopic methods.
  
  
  METHODS
  Various kinds of IMC tablets (200 mg) were obtained from a powder (20 mg of IMC, 18 mg of microcrystalline cellulose, 160 mg of lactose, and 2 mg of magnesium stearate) under various compression pressures (60-398 MPa). Dissolution tests were performed in phosphate buffer, and the time required for 75% dissolution (T75) and mean dissolution time (MDT) were calculated. DRNIR and TNIR spectra were recorded, and the both NIR spectra used to establish a calibration model for predicting the dissolution properties by principal component regression analysis (PCR).
  
  
  RESULTS
  The T75 and MDT increased as the compression pressure increased, since tablet porosity decreased with increasing pressure. Intensity of the DRNIR spectra of the compressed tablets decreased as the compression pressure increased. However, the intensity of TNIR spectra increased along with the pressure. The calibration models used to evaluate the dissolution properties of tablets were established by using PCR based on both DRNIR and TNIR spectra of the tablets. The multiple correlation coefficients of the relationship between the actual and predictive T75 by the DRNIR and TNIR methods were 0.831 and 0.962, respectively.
  
  
  CONCLUSIONS
  It is possible to predict the dissolution properties of pharmaceutical preparations using both DRNIR and TNIR chemoinformetric methods. The TNIR method was more accurate for predictions of the dissolution behavior of tablets than the DRNIR method.
authors.affiliation: Research Institute of Pharmaceutical Sciences, Faculty of Pharmacy, Musashino University, Shinmachi 1-1-20, Nishi-Tokyo, Tokyo 202-8585, Japan. motsuka@musashino-u.ac.jp
authors.forename: Makoto
authors.initials: M
authors.lastname: Otsuka
authors.forename: Hideaki
authors.initials: H
authors.lastname: Tanabe
authors.forename: Kazuo
authors.initials: K
authors.lastname: Osaki
authors.forename: Kuniko
authors.initials: K
authors.lastname: Otsuka
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Ozaki
mesh_terms: D002138:Calibration; D007213:Indomethacin / Q000737:chemistry*; D011312:Pressure; D012995:Solubility; D019265:Spectroscopy, Near-Infrared; D013607:Tablets; D013678:Technology, Pharmaceutical
chemical_list: D013607:Tablets; D007213:Indomethacin