title: High activity of meropenem against Gram-negative bacteria from a paediatric Intensive Care Unit, 2001-2005.
abstract: The susceptibility of Gram-negative bacterial strains (n=620) isolated from clinical specimens of children hospitalized in a paediatric Intensive Care Unit between 2001 and 2005 was tested. Meropenem, imipenem and ciprofloxacin were most active (>90% susceptibility) against the tested isolates, with no observed reduction in activity over 5 years. A decrease in prevalence of extended-spectrum beta-lactamase and AmpC beta-lactamase producing Enterobacteriaceae from 56.3 to 34.1% was found.
authors.affiliation: Department of Clinical Microbiology and Immunology, The Children's Memorial Health Institute, Al. Dzieci Polskich 20, 04-730 Warsaw, Poland. j.patzer@czd.pl
authors.forename: Jan A
authors.initials: JA
authors.lastname: Patzer
authors.forename: Danuta
authors.initials: D
authors.lastname: Dzierzanowska
authors.forename: Alicja
authors.initials: A
authors.lastname: Pawińska
authors.forename: Philip J
authors.initials: PJ
authors.lastname: Turner
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000096:biosynthesis; D002648:Child; D004755:Enterobacteriaceae / Q000187:drug effects / Q000201:enzymology / Q000302:isolation & purification; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D016905:Gram-Negative Bacterial Infections / Q000188:drug therapy / Q000382:microbiology; D006801:Humans; D066298:In Vitro Techniques; D015278:Intensive Care Units, Pediatric; D000077731:Meropenem; D008826:Microbial Sensitivity Tests; D011044:Poland; D013845:Thienamycins / Q000494:pharmacology*; D001618:beta-Lactamases / Q000096:biosynthesis
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D013845:Thienamycins; C048795:AmpC beta-lactamases; D001618:beta-Lactamases; D000077731:Meropenem