title: Primary mediastinal anaplastic alk-1-positive large-cell lymphoma of T/NK-cell type expressing CD20.
abstract: We describe an unusual case of ALK-1-positive primary mediastinal lymphoma with the morphology of an anaplastic large-cell lymphoma (ALCL) of T/NK cell type but expressing CD20. This tumour had T/NK morphology and immunophenotype, as demonstrated by its expression of CD30, EMA, ALK-1, CD7 and TiA-1 and the lack of expression of B-cell markers other than CD20. The significance of such a co-expression of a B cell-associated antigen in a case of ALCL of T/NK cell type is discussed.
authors.affiliation: Service Central d'Anatomie et Cytologie Pathologiques, Jacques Delarue, Hôtel-Dieu, 1, place du parvis Notre-Dame, 75181, Paris Cedex 04, France.
authors.forename: J
authors.initials: J
authors.lastname: Gonin
authors.forename: H
authors.initials: H
authors.lastname: Kadiri
authors.forename: S
authors.initials: S
authors.lastname: Bensaci
authors.forename: A
authors.initials: A
authors.lastname: Le Tourneau
authors.forename: T J
authors.initials: TJ
authors.lastname: Molina
authors.forename: J
authors.initials: J
authors.lastname: Diebold
authors.forename: D J
authors.initials: DJ
authors.lastname: Abdellouche
authors.forename: J
authors.initials: J
authors.lastname: Audouin
mesh_terms: D030301:Activin Receptors, Type II / Q000378:metabolism*; D018951:Antigens, CD20 / Q000378:metabolism*; D014408:Biomarkers, Tumor / Q000378:metabolism; D002648:Child; D006801:Humans; D016130:Immunophenotyping; D007694:Killer Cells, Natural / Q000378:metabolism / Q000473:pathology*; D017728:Lymphoma, Large-Cell, Anaplastic / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008479:Mediastinal Neoplasms / Q000378:metabolism / Q000473:pathology*; D013601:T-Lymphocytes / Q000378:metabolism / Q000473:pathology*
chemical_list: D018951:Antigens, CD20; D014408:Biomarkers, Tumor; C425364:ACVRL1 protein, human; D030301:Activin Receptors, Type II