New constituents from the leaves of Morinda citrifolia.
A new iridoid glycoside, citrifoside (1), and a new anthraquinone, 1,5,15-trimethylmorindol (2), together with 24 known compounds, were isolated from the leaves of Morinda citrifolia. The structures of the new compounds were elucidated by spectral data. 1,5,15-Trimethylmorindol (2) did not show significant cytotoxic activity by itself but showed cytotoxicity when combined with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), while citrifoside (1) did not show any activity even with TRAIL.
Takashima
Junko
J
Pharmaceuticals Research Division, Mitsubishi Pharma Corporation, Yokohama, Japan. Takashima.Junko@me.m-pharma.co.jp
Ikeda
Yoshitaka
Y
Komiyama
Kanki
K
Hayashi
Masahiko
M
Kishida
Akio
A
Ohsaki
Ayumi
A
D000880:Anthraquinones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D039823:Iridoids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D019169:Jurkat Cells / Q000187:drug effects / Q000378:metabolism; D015394:Molecular Structure; D032066:Morinda / Q000737:chemistry*; D018515:Plant Leaves / Q000737:chemistry*; D010946:Plants, Medicinal; D053221:TNF-Related Apoptosis-Inducing Ligand / Q000378:metabolism
C518853:1,5,15-trimethylmorindol; D000880:Anthraquinones; D006027:Glycosides; D039823:Iridoids; D053221:TNF-Related Apoptosis-Inducing Ligand; C518852:citrifoside