title: Soluble CD26 and CD30 levels in patients with anthroponotic cutaneous leishmaniasis.
abstract: OBJECTIVE
  Leishmania tropica is the causative agent of anthroponotic cutaneous leishmaniasis (CL) in Iran. The disease often heals within a year; however, the non-healing forms of disease are also known. The aim of the present study was the determination of the levels of soluble (s) CD26 and CD30 co-stimulatory molecules in sera of L. tropica-infected individuals. The correlations of sCD26 and sCD30 levels with clinical presentation of the disease were assessed.
  
  
  METHODS
  The levels of sCD26 and sCD30 were determined by a sandwich enzyme-linked immunosorbent assay in sera from patients with acute and non-healing presentation of disease.
  
  
  RESULTS
  The serum level of sCD26 was significantly higher in non-healing patients than in cases with acute CL (P<0.001). There was no significant difference in sCD26 level between patients with acute CL and healthy controls. However, the levels of sCD30 in sera from all L. tropica-infected individuals were higher than controls (P<0.001). A significant difference was also found in sCD30 level between non-healing cases and patients with acute CL (P<0.001).
  
  
  CONCLUSIONS
  These findings suggest sCD30 is more relevant to clinical manifestation of cutaneous leishmaniasis than sCD26. The high sCD26 and sCD30 levels in non-healing patients reflect the presence of mixed Th1- and Th2-type responses in these patients.
authors.affiliation: Immunology Department, Pasteur Institute of Iran, Pasteur Avenue, Tehran 13164, Iran. sohary@yahoo.com
authors.forename: Soheila
authors.initials: S
authors.lastname: Ajdary
authors.forename: Reza
authors.initials: R
authors.lastname: Jafari-Shakib
authors.forename: Farhad
authors.initials: F
authors.lastname: Riazi-Rad
authors.forename: Ali
authors.initials: A
authors.lastname: Khamesipour
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000818:Animals; D015415:Biomarkers / Q000097:blood; D002648:Child; D018819:Dipeptidyl Peptidase 4 / Q000097:blood*; D005260:Female; D006801:Humans; D017730:Ki-1 Antigen / Q000097:blood*; D007895:Leishmania tropica / Q000472:pathogenicity; D016773:Leishmaniasis, Cutaneous / Q000276:immunology* / Q000469:parasitology / Q000503:physiopathology*; D008297:Male; D012995:Solubility
chemical_list: D015415:Biomarkers; D017730:Ki-1 Antigen; D018819:Dipeptidyl Peptidase 4