title: Studies on argyrophilic nucleolar organizer regions (AgNORs) in a spontaneous mammary gland ductal carcinoma of a captive rhesus monkey.
abstract: A spontaneous mammary gland ductal carcinoma was diagnosed in a 13-year-old female captive rhesus monkey (Macaca mulatta). The expression of argyrophilic nucleolar organizer regions (AgNORs) was studied to investigate the correlation between the histologic invasiveness and cell proliferation activity assay for predicting the biologic behavior of this tumor type. The results of this study show that the AgNOR size in tumor cells reflect the degree of malignancy when compared with the pattern of peripheral blood lymphocytes of the same individual. This is the first study showing a significant AgNOR feature of a malignant breast tumor in a rhesus monkey and it longs to provide additional diagnostic tool in tumor pathology.
authors.affiliation: Oswaldo Cruz Foundation, Center for Laboratory Animal Breeding, Department of Primatology, Av. Brasil, 4365 Manguinhos, 21040-900 Rio de Janeiro/RJ, Brazil. bibi@fiocruz.br
authors.forename: Beatriz
authors.initials: B
authors.lastname: Goldschmidt
authors.forename: Renato Sergio
authors.initials: RS
authors.lastname: Marchevsky
authors.forename: Marcia Cristina Ribeiro
authors.initials: MC
authors.lastname: Andrade
authors.forename: Claudia Andréia de Araújo
authors.initials: CA
authors.lastname: Lopes
authors.forename: Miguel Angelo Bruck
authors.initials: MA
authors.lastname: Gonçalves
authors.forename: Antonio da Mota
authors.initials: Ada M
authors.lastname: Marinho
authors.forename: Taya Figueiredo
authors.initials: TF
authors.lastname: de Oliveira
mesh_terms: D000818:Animals; D044584:Carcinoma, Ductal / Q000473:pathology / Q000648:ultrastructure* / Q000662:veterinary; D005260:Female; D008214:Lymphocytes / Q000648:ultrastructure; D008253:Macaca mulatta; D015674:Mammary Neoplasms, Animal / Q000473:pathology / Q000648:ultrastructure*; D008992:Monkey Diseases / Q000473:pathology*; D009697:Nucleolus Organizer Region / Q000648:ultrastructure*; D011379:Prognosis