title: Nup88 expression in normal mucosa, adenoma, primary adenocarcinoma and lymph node metastasis in the colorectum.
abstract: OBJECTIVE
  It was the aim of this study to investigate Nup88 expression in normal colorectal mucosa, adenoma, adenocarcinoma and lymph node metastasis, as well as the relationship between Nup88 expression and clinicopathological features.
  
  
  METHODS
  Nup88 expression was examined by immunohistochemistry in 84 normal mucosa samples, 32 adenomas, 181 primary adenocarcinomas, and 18 lymph node metastases from colorectal tumour patients.
  
  
  RESULTS
  Nup88 expression was observed in normal epithelial and tumour cells. The frequency of strong Nup88 expression was increased from normal mucosa or adenoma to primary tumour and lymph node metastasis (p < 0.0001). There was no significant difference in the expression between normal mucosa and adenoma (p = 0.41). The frequency of strong Nup88 expression was higher in ulcerated tumours (40%) than in polypoid/large fungating tumours (23%; p = 0.048). The frequency of strong Nup88 expression was significantly different among tumours with good (21%), moderate (42%) and poor differentiation (48%; p = 0.01). Nup88 expression was not related to the patients' gender, age, tumour location, size, histological type, invasive depth, lymph node status and Dukes stage (p > 0.05).
  
  
  CONCLUSIONS
  Our results suggest that Nup88 may play a role during the development, aggressiveness and differentiation of colorectal tumours.
authors.affiliation: Department of Pathology, Tangshan Worker's Hospital, Tangshan, China.
authors.forename: Zhi-Yong
authors.initials: ZY
authors.lastname: Zhang
authors.forename: Zeng-Ren
authors.initials: ZR
authors.lastname: Zhao
authors.forename: Li
authors.initials: L
authors.lastname: Jiang
authors.forename: Jia-Chen
authors.initials: JC
authors.lastname: Li
authors.forename: Yan-Min
authors.initials: YM
authors.lastname: Gao
authors.forename: Dong-Sheng
authors.initials: DS
authors.lastname: Cui
authors.forename: Che-Jiang
authors.initials: CJ
authors.lastname: Wang
authors.forename: Jose
authors.initials: J
authors.lastname: Schneider
authors.forename: Ming-Wei
authors.initials: MW
authors.lastname: Wang
authors.forename: Xiao-Feng
authors.initials: XF
authors.lastname: Sun
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism* / Q000556:secondary; D000236:Adenoma / Q000378:metabolism*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor; D015179:Colorectal Neoplasms / Q000378:metabolism* / Q000473:pathology; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism* / Q000473:pathology; D008198:Lymph Nodes / Q000378:metabolism; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D028861:Nuclear Pore Complex Proteins / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; C104835:NUP88 protein, human; D028861:Nuclear Pore Complex Proteins