title: Risk factors and histological outcome of abnormal cervix with human papilloma infection in northeastern Thai-women.
abstract: This study aimed to investigate the histological outcome of cervix with human papillomavirus (HPV) infection and the association of risk factors with cervical intraepithelial neoplasia (CIN) and invasive cervical carcinoma (ICC) development in Northeast Thai women. The study population (n=210) comprised 71 cases of normal cervix, 71 cases of CIN and 68 cases of ICC. The histological outcome of HPV infection was determined for 9.5% of the study population. Increased risk factors for CIN were observed for more than one partner (odds ratio (OR)=3.75, p<0.05), history of sexually transmitted disease (STD) (OR=2.28, p<0.05), menarche under 14 years of age (OR=0.31, p<0.05) and partners' smoking history (OR=3.98, p<0.01). Increased risk for ICC was observed for those with a history of STDs (OR=0.14, p<0.01) and multiparity (OR=2.53, p<0.01). Age at first sexual intercourse was not a risk factor in this study population. Further studies with HPV-DNA tests should more precisely quantify the risks.
authors.affiliation: Division of Pathology, Faculty of Medicine, Thammasart University, Pathum Thani, Thailand. nipa.kanjana@yahoo.com
authors.forename: Nipa
authors.initials: N
authors.lastname: Kanjanavirojkul
authors.forename: Chawalit
authors.initials: C
authors.lastname: Pairojkul
authors.forename: Pissamai
authors.initials: P
authors.lastname: Yuenyao
authors.forename: Natcha
authors.initials: N
authors.lastname: Patarapadungkit
mesh_terms: D000328:Adult; D002584:Cervix Uteri / Q000821:virology; D016009:Chi-Square Distribution; D005260:Female; D006801:Humans; D027383:Papillomaviridae / Q000302:isolation & purification; D030361:Papillomavirus Infections / Q000453:epidemiology* / Q000473:pathology*; D012307:Risk Factors; D012725:Sexual Behavior; D015229:Sexually Transmitted Diseases, Viral / Q000453:epidemiology / Q000473:pathology / Q000821:virology; D011795:Surveys and Questionnaires; D013785:Thailand / Q000453:epidemiology; D002578:Uterine Cervical Dysplasia / Q000453:epidemiology / Q000821:virology