title: Arenicolides A-C, 26-membered ring macrolides from the marine actinomycete Salinispora arenicola.
abstract: Chemical evaluation of the saline fermentation broth of several strains of the obligate marine actinomycete Salinispora arenicola has led to the identification of three new macrolide polyketides designated arenicolides A-C (1-3). The planar structures, elucidated via spectroscopic and chemical methods, consist of 26-membered polyunsaturated macrolactones containing repeating vicinal hydroxyl methoxyl moieties. The relative and absolute stereochemistries of 1-3 were assigned by a combination of J-based configurational analyses and chemical derivatization.
authors.affiliation: Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California-San Diego, La Jolla, California 92093-0204, USA.
authors.forename: Philip G
authors.initials: PG
authors.lastname: Williams
authors.forename: Eric D
authors.initials: ED
authors.lastname: Miller
authors.forename: Ratnakar N
authors.initials: RN
authors.lastname: Asolkar
authors.forename: Paul R
authors.initials: PR
authors.lastname: Jensen
authors.forename: William
authors.initials: W
authors.lastname: Fenical
mesh_terms: D000096:Acetone / Q000737:chemistry; D039903:Actinobacteria / Q000737:chemistry*; D000475:Alkenes; D002942:Circular Dichroism; D018942:Macrolides / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009792:Oceans and Seas; D013237:Stereoisomerism
chemical_list: D000475:Alkenes; D018942:Macrolides; C521798:arenicolide A; C521799:arenicolide B; C521800:arenicolide C; D000096:Acetone