IVIG therapy: interfering with interferon-gamma.
The immunosuppressive mechanism of action of intravenous immune globulin (IVIG) has remained enigmatic despite the many years of clinical experience in the treatment of autoimmunity. In this issue of Immunity, Park-Min et al. demonstrate that IVIG engagement of Fcgamma RIII receptor on monocytes inhibits the cellular response to interferon-gamma.
Clynes
Raphael
R
Department of Medicine and Microbiology, Columbia University, New York, NY 10032, USA. rc645@columbia.edu
D000818:Animals; D001327:Autoimmune Diseases / Q000188:drug therapy; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000276:immunology*; D007371:Interferon-gamma / Q000276:immunology*; D018448:Models, Immunological; D009000:Monocytes / Q000276:immunology*; D017452:Receptors, IgG / Q000276:immunology*
D016756:Immunoglobulins, Intravenous; D017452:Receptors, IgG; D007371:Interferon-gamma