title: Children's vaccines do not induce cross reactivity against SARS-CoV.
abstract: In contrast with adults, children infected by severe acute respiratory syndrome-corona virus (SARS-CoV) develop milder clinical symptoms. Because of this, it is speculated that children vaccinated with various childhood vaccines might develop cross immunity against SARS-CoV. Antisera and T cells from mice immunised with various vaccines were used to determine whether they developed cross reactivity against SARS-CoV. The results showed no marked cross reactivity against SARS-CoV, which implies that the reduced symptoms among children infected by SARS-CoV may be caused by other factors.
authors.affiliation: State Key Laboratory for Agro-Biotechnology, College of Biological Science, China Agricultural University, Beijing, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Yu
authors.forename: Huali
authors.initials: H
authors.lastname: Jin
authors.forename: Ze
authors.initials: Z
authors.lastname: Chen
authors.forename: Qingling L
authors.initials: QL
authors.lastname: Yu
authors.forename: Yijie J
authors.initials: YJ
authors.lastname: Ma
authors.forename: Xiaolin L
authors.initials: XL
authors.lastname: Sun
authors.forename: Bin
authors.initials: B
authors.lastname: Wang
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D002648:Child; D002675:Child, Preschool; D003429:Cross Reactions / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D006801:Humans; D007106:Immune Sera / Q000276:immunology; D007114:Immunization; D007223:Infant; D051379:Mice; D008810:Mice, Inbred C57BL; D045473:Severe acute respiratory syndrome-related coronavirus / Q000276:immunology*; D045169:Severe Acute Respiratory Syndrome / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology; D014612:Vaccines / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral; D007106:Immune Sera; D014612:Vaccines