title: Lack of association between antimyelin antibodies and progression to multiple sclerosis.
abstract: BACKGROUND
  Patients with a single episode of neurologic dysfunction and brain magnetic resonance imaging (MRI) scans suggestive of multiple sclerosis are at high risk for clinically definite multiple sclerosis, but the outcome for individual patients is unpredictable. An increased risk of progression to clinically definite multiple sclerosis in patients with serum antibodies against myelin oligodendrocyte glycoprotein (MOG) and myelin basic protein (MBP) has been reported.
  
  
  METHODS
  We measured serum anti-MOG and anti-MBP IgG and IgM antibodies in 462 patients with a first clinical event suggestive of multiple sclerosis and at least two clinically silent lesions on brain MRI. The patients were participating in a multicenter trial of treatment with interferon beta-1b. Antibodies were assessed by Western blot analysis at baseline, and the results compared with the time and rate of progression to clinically definite multiple sclerosis or a diagnosis of multiple sclerosis as defined by an international panel (the McDonald criteria). Regular visits were scheduled for the assessment of neurologic impairment and for MRI before treatment and at months 3, 6, 9, 12, 18, and 24.
  
  
  RESULTS
  No associations were found between the presence of anti-MOG and anti-MBP IgM and IgG antibodies and progression to clinically definite multiple sclerosis or a diagnosis of multiple sclerosis according to the McDonald criteria, either in the entire cohort or in any subgroups of the study population.
  
  
  CONCLUSIONS
  Serum antibodies against MOG and MBP, as detected by Western blot analysis, are not associated with an increased risk of progression to clinically definite multiple sclerosis in patients who have had a clinically isolated syndrome suggestive of multiple sclerosis.
authors.affiliation: Department of Research, University Hospital, Basel, Switzerland.
authors.forename: Jens
authors.initials: J
authors.lastname: Kuhle
authors.forename: Christoph
authors.initials: C
authors.lastname: Pohl
authors.forename: Matthias
authors.initials: M
authors.lastname: Mehling
authors.forename: Gilles
authors.initials: G
authors.lastname: Edan
authors.forename: Mark S
authors.initials: MS
authors.lastname: Freedman
authors.forename: Hans-Peter
authors.initials: HP
authors.lastname: Hartung
authors.forename: Chris H
authors.initials: CH
authors.lastname: Polman
authors.forename: David H
authors.initials: DH
authors.lastname: Miller
authors.forename: Xavier
authors.initials: X
authors.lastname: Montalban
authors.forename: Frederik
authors.initials: F
authors.lastname: Barkhof
authors.forename: Lars
authors.initials: L
authors.lastname: Bauer
authors.forename: Susanne
authors.initials: S
authors.lastname: Dahms
authors.forename: Raija
authors.initials: R
authors.lastname: Lindberg
authors.forename: Ludwig
authors.initials: L
authors.lastname: Kappos
authors.forename: Rupert
authors.initials: R
authors.lastname: Sandbrink
mesh_terms: D000276:Adjuvants, Immunologic / Q000627:therapeutic use; D000328:Adult; D001323:Autoantibodies / Q000097:blood*; D001921:Brain / Q000473:pathology; D018450:Disease Progression; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood*; D000068576:Interferon beta-1b; D016899:Interferon-beta / Q000627:therapeutic use; D053208:Kaplan-Meier Estimate; D008279:Magnetic Resonance Imaging; D008297:Male; D009103:Multiple Sclerosis / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology*; D004676:Myelin Basic Protein / Q000276:immunology*; D009185:Myelin Proteins; D018992:Myelin-Associated Glycoprotein / Q000276:immunology*; D063308:Myelin-Oligodendrocyte Glycoprotein; D016016:Proportional Hazards Models
chemical_list: D000276:Adjuvants, Immunologic; D001323:Autoantibodies; D007074:Immunoglobulin G; D007075:Immunoglobulin M; C571326:MOG protein, human; D004676:Myelin Basic Protein; D009185:Myelin Proteins; D018992:Myelin-Associated Glycoprotein; D063308:Myelin-Oligodendrocyte Glycoprotein; D000068576:Interferon beta-1b; D016899:Interferon-beta