Glycomic approaches toward drug development: therapeutically exploring the glycosaminoglycanome.
The science of decoding the information contained within complex glycan structures is commonly referred to as 'glycomics'. Information flow is usually governed by the binding of proteins to these glycan structures, resulting in the induction of biological processes such as cell migration and activation. Therapeutic approaches which interfere with this glyco-information flow are described.
Gesslbauer
Bernd
B
University of Graz, Institute of Pharmaceutical Sciences, A-8010 Graz, Austria.
Kungl
Andreas J
AJ
D002240:Carbohydrate Sequence; D015195:Drug Design; D006025:Glycosaminoglycans / Q000737:chemistry / Q000378:metabolism* / Q000627:therapeutic use*; D006801:Humans; D008969:Molecular Sequence Data; D015394:Molecular Structure; D011485:Protein Binding; D021241:Spectrometry, Mass, Electrospray Ionization
D006025:Glycosaminoglycans