Specificity of anti-human leukocyte antigen antibody responses after immunization with Remune, an inactivated HIV-1 vaccine.
Antibody responses against human leukocyte antigen (HLA) classes I and II were detected in HIV-1 infected individuals who received a fixed inactivated HIV-1 (Remune) immunotherapy. The response was specific for HLA-B62 and HLA-DR4 concordant with the host cell line, HUT-78, used in vaccine production. These responses were not detected in HLA-B62 and HLA-DR4-positive individuals indicating that immunotherapy did not break tolerance to self-antigens.
Page
Mark
M
Division of Retrovirology, National Institute for Biological Standards and Control, Potters Bar EN6 3QG, UK.
Ojugo
Agatha
A
Imami
Nesrina
N
Hardy
Gareth
G
Gotch
Frances
F
Almond
Neil
N
D016915:AIDS Vaccines / Q000276:immunology*; D000918:Antibody Specificity; D023241:Antiretroviral Therapy, Highly Active; D015497:HIV-1; D006680:HLA Antigens / Q000276:immunology*; D006650:Histocompatibility Testing; D006801:Humans; D007518:Isoantibodies / Q000096:biosynthesis*; D008297:Male; D015164:Vaccines, Inactivated / Q000276:immunology
D016915:AIDS Vaccines; D006680:HLA Antigens; D007518:Isoantibodies; D015164:Vaccines, Inactivated; C105086:remune