title: HER2/neu expression in relation to clinicopathologic features of breast cancer patients.
abstract: We have evaluated HER2/neu expression in 1,355 breast cancer patients recruited at the Breast Cancer Registry in Palermo between January 1999 and December 2004. In this retrospective study, HER2/neu expression was related to clinicopathologic features of the disease, including tumor size, nodal and menopausal status, estrogen and progesterone receptors. Statistical analysis on all 1,355 patients showed a significant correlation between HER2/neu and nodal status (P < 0.001), and a significant association between HER2/neu overexpression and estrogen and progesterone receptors status (P < 0.001). In 194 patients without metastasis, with an average follow-up > or =5 years, only HER2/neu 3+ and histopathologic grading G3 were significantly associated with overall survival.
authors.affiliation: Experimental Oncology, Department of Oncology, P.O. M. Ascoli, via Parlavecchio n. 139, 90127 Palermo, Italy. registrotumori@ospedalecivicopa.org
authors.forename: Adele
authors.initials: A
authors.lastname: Traina
authors.forename: Biagio
authors.initials: B
authors.lastname: Agostara
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Marasà
authors.forename: Maurizio
authors.initials: M
authors.lastname: Calabrò
authors.forename: Maurizio
authors.initials: M
authors.lastname: Zarcone
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Carruba
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000401:mortality / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D008875:Middle Aged; D011379:Prognosis; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000032:analysis* / Q000235:genetics / Q000378:metabolism; D016019:Survival Analysis
chemical_list: D018719:Erb-b2 Receptor Tyrosine Kinases