Effect of acetyl 11-keto beta-boswellic acid on metastatic growth factor responsible for angiogenesis.
Basic fibroblast growth factor (bFGF), a metastatic growth factor is known to be one of the promoting factors in the tumor induced angiogenesis. The antiangiogenic activity of acetyl 11-keto beta-boswellic acid was screened against bFGF-induced angiogenesis using in-vivo Matrigel Plug Assay. Histological & colorimetric examination confirmed that numerous blood vessels were present in Matrigel+bFGF group in comparison to Matrigel alone treated mice. Acetyl 11-keto beta-boswellic acids (10 mg/kg/d) inhibited the Matrigel+bFGF-induced angiogenesis significantly (P<0.01) in contrast to anti-inflammatory agent indomethacin (10 mg/kg/d) and alkylating agent cyclophosphamide (10 mg/kg/d).
Singh
Shashank Kumar
SK
Pharmacology Division, Regional Research Laboratory, Jammu, India. shashankkumarsingh@gmail.com
Bhusari
Sachin
S
Singh
Reena
R
Saxena
Ajit
A
Mondhe
Dilip
D
Qazi
Ghulam Nabi
GN
D020533:Angiogenesis Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D018906:Antineoplastic Agents, Alkylating / Q000494:pharmacology; D003094:Collagen; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology; D003520:Cyclophosphamide / Q000494:pharmacology; D004195:Disease Models, Animal; D004338:Drug Combinations; D016222:Fibroblast Growth Factor 2; D007213:Indomethacin / Q000494:pharmacology; D007797:Laminin; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009389:Neovascularization, Pathologic / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D011509:Proteoglycans; D015203:Reproducibility of Results; D040521:Subcutaneous Tissue / Q000098:blood supply*; D014315:Triterpenes / Q000494:pharmacology* / Q000627:therapeutic use
D020533:Angiogenesis Inhibitors; D018906:Antineoplastic Agents, Alkylating; D016861:Cyclooxygenase Inhibitors; D004338:Drug Combinations; D007797:Laminin; D011509:Proteoglycans; D014315:Triterpenes; C094432:acetyl-11-ketoboswellic acid; D016222:Fibroblast Growth Factor 2; C059485:matrigel; D003520:Cyclophosphamide; D003094:Collagen; D007213:Indomethacin