Minor increase of endtidal CO2 during sevoflurane-induced malignant hyperthermia.
Malignant hyperthermia (MH) in a pediatric patient during sevoflurane anesthesia with only a minor rise of endtidal CO(2) is described. MH was considered because of increased rectal temperature. The outcome was favorable after the initiation of a few simple measures (increased minute ventilation, cessation of sevoflurane). As recommended by the regional MH Reference Center, dantrolene was not used. In vitro contracture tests were performed on muscle biopsies from both parents. A strong contracture in response to halothane confirmed the father's MH susceptibility, thereby according a high probability of an MH episode in his son.
Bonciu
Monalisa
M
Département d'Anesthésie-Réanimation Ouest, CHU Nice, Nice, France. monabonciu@yahoo.com
de la Chapelle
Arnaud
A
Delpech
Henry
H
Depret
Thiery
T
Krivosic-Horber
Reneé
R
Aimé
Marc Raucoules
MR
D018685:Anesthetics, Inhalation / Q000009:adverse effects*; D018686:Anesthetics, Intravenous / Q000008:administration & dosage; D001706:Biopsy / Q000379:methods; D001831:Body Temperature / Q000187:drug effects; D002245:Carbon Dioxide / Q000032:analysis; D002648:Child; D002781:Cholesteatoma / Q000601:surgery; D003402:Creatine Kinase / Q000097:blood; D000077324:Crystalloid Solutions; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007552:Isotonic Solutions / Q000008:administration & dosage; D008297:Male; D008305:Malignant Hyperthermia / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy*; D008738:Methyl Ethers / Q000009:adverse effects*; D009119:Muscle Contraction / Q000187:drug effects; D009211:Myoglobin / Q000097:blood; D009924:Organ Culture Techniques; D010290:Parents; D010880:Piperidines / Q000008:administration & dosage; D052097:Quadriceps Muscle / Q000473:pathology; D000077208:Remifentanil; D012121:Respiration, Artificial / Q000379:methods*; D000077149:Sevoflurane; D014433:Tympanoplasty / Q000379:methods
D018685:Anesthetics, Inhalation; D018686:Anesthetics, Intravenous; D000077324:Crystalloid Solutions; D007552:Isotonic Solutions; D008738:Methyl Ethers; D009211:Myoglobin; D010880:Piperidines; D002245:Carbon Dioxide; D000077149:Sevoflurane; D003402:Creatine Kinase; D000077208:Remifentanil