Detection of antibodies against p63 and p73 isoforms in sera from patients diagnosed with oral lichen planus.
BACKGROUND
Oral lichen planus (OLP) is a chronic inflammatory disease of oral mucosa. Despite numerous publications and intense research, the etiology of OLP is still unknown, however, autoimmunity as a possible causative factor has been discussed.


METHODS
In the present study sera from 20 patients clinically and histologically diagnosed with OLP were analyzed for antibodies directed toward p53, p63, and p73 using Western blot.


RESULTS
Sera from two patients reacted with all six p63 isoforms, and one also with p73. The strongest reaction was noted against the TAp63beta protein, which is the most potent transactivator of all p63 proteins and is implicated in the differentiation of stratified epithelia.


CONCLUSIONS
This is the first demonstration of antibodies directed against all p63 and some p73 isoforms in sera from patients diagnosed with OLP.
Ebrahimi
Majid
M
Department of Odontology, Umeå University, Umeå, Sweden. majid.ebrahimi@medbio.umu.se
Wahlin
Ylva-Britt
YB
Coates
Philip J
PJ
Wiik
Allan
A
Roos
Göran
G
Nylander
Karin
K
D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D016022:Case-Control Studies; D004268:DNA-Binding Proteins / Q000276:immunology*; D005260:Female; D006801:Humans; D017676:Lichen Planus, Oral / Q000097:blood* / Q000276:immunology; D008297:Male; D008565:Membrane Proteins / Q000276:immunology; D051379:Mice; D008875:Middle Aged; D009687:Nuclear Proteins / Q000276:immunology*; D011817:Rabbits; D000072160:Tumor Protein p73; D016159:Tumor Suppressor Protein p53 / Q000276:immunology*; D025521:Tumor Suppressor Proteins / Q000276:immunology*
C081876:CKAP4 protein, human; D004268:DNA-Binding Proteins; D008565:Membrane Proteins; D009687:Nuclear Proteins; C000606460:TP73 protein, human; C000606368:Trp73 protein, mouse; D000072160:Tumor Protein p73; D016159:Tumor Suppressor Protein p53; D025521:Tumor Suppressor Proteins