title: Ki67 expression levels are a better marker of reduced melanoma growth following MEK inhibitor treatment than phospho-ERK levels.
abstract: The loss of tumour phospho-extracellular responsive kinase (pERK) positivity is the major treatment biomarker for mitogen-activated protein kinase/extracellular responsive kinase (MEK) inhibitors. Here, we demonstrate that there is a poor correlation between pERK inhibition and the anti-proliferative effects of MEK inhibitors in melanoma cells. We suggest that Ki67 is a better biomarker for future clinical studies.
authors.affiliation: The Wistar Institute, 3601 Spruce Street, Philadelphia, Pennsylvania, 19104, USA. ksmalley@wistar.org
authors.forename: K S M
authors.initials: KS
authors.lastname: Smalley
authors.forename: R
authors.initials: R
authors.lastname: Contractor
authors.forename: N K
authors.initials: NK
authors.lastname: Haass
authors.forename: J T
authors.initials: JT
authors.lastname: Lee
authors.forename: K L
authors.initials: KL
authors.lastname: Nathanson
authors.forename: C A
authors.initials: CA
authors.lastname: Medina
authors.forename: K T
authors.initials: KT
authors.lastname: Flaherty
authors.forename: M
authors.initials: M
authors.lastname: Herlyn
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis*; D002070:Butadienes / Q000032:analysis; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D048049:Extracellular Signal-Regulated MAP Kinases / Q000032:analysis* / Q000037:antagonists & inhibitors*; D016193:G1 Phase; D006801:Humans; D019394:Ki-67 Antigen / Q000032:analysis*; D008545:Melanoma / Q000188:drug therapy* / Q000473:pathology; D020929:Mitogen-Activated Protein Kinase Kinases / Q000037:antagonists & inhibitors*; D009154:Mutation; D009570:Nitriles / Q000032:analysis; D000081082:Phosphoinositide-3 Kinase Inhibitors; D010766:Phosphorylation; D048493:Proto-Oncogene Proteins B-raf / Q000235:genetics
chemical_list: D014408:Biomarkers, Tumor; D002070:Butadienes; D019394:Ki-67 Antigen; D009570:Nitriles; D000081082:Phosphoinositide-3 Kinase Inhibitors; C113580:U 0126; C482119:BRAF protein, human; D048493:Proto-Oncogene Proteins B-raf; D048049:Extracellular Signal-Regulated MAP Kinases; D020929:Mitogen-Activated Protein Kinase Kinases