title: Minimally invasive closed circuit versus standard extracorporeal circulation for aortic valve replacement.
abstract: BACKGROUND
  The purpose of this study was to evaluate the safety and clinical results of aortic valve replacement performed with minimally invasive closed circuit extracorporeal circulation technique (MECC system) versus standard cardiopulmonary bypass.
  
  
  METHODS
  Forty consecutive patients undergoing isolated aortic valve replacement at a single institution were randomly assigned to either miniaturized closed circuit cardiopulmonary bypass with the Maquet-Cardiopulmonary (Rastatt, Germany) minimal extracorporeal circulation (MECC) system (study group B, n = 17) or standard cardiopulmonary bypass (control group A, n = 23). The MECC system is a low priming circuit without blood-air interface. Technical feasibility, in particular the potential entry of air in the circuit, and clinical results were prospectively evaluated.
  
  
  RESULTS
  Demographic characteristics and surgical data were similar in both groups. Patients in the study group showed reduced chest tube drainage (217 +/- 62 mL vs 420 +/- 219 mL, p < 0.05) and blood transfusion requirements (5.1% vs 43.4%, p < 0.02) compared with patients in the control group. Moreover, the study group showed significantly higher time course of hematocrit at all time points during the operation and longer hospital stay (p < 0.02) than the control group; similarly, in the study group patients' platelet count in intensive care unit admission was significantly higher than the control group (140 +/- 29 x 10(9)/L vs 119 +/- 37 x 10(9)/L, p < 0.05). Peak postoperative troponin C release was significantly lower in the study group (4.74 +/- 2.82 vs 8.43 +/- 6.25 ng/dL, p < 0.033). One patient undergoing the MECC system operation showed a major neurologic event on postoperative day four, which was probably secondary to severe aortic calcification.
  
  
  CONCLUSIONS
  The MECC system is suitable for aortic valve replacement and provides better clinical results than standard cardiopulmonary bypass as regards blood transfusion requirements, platelets consumption, and myocardial damage.
authors.affiliation: Department of Cardiac Surgery, San Raffaele Hospital, Milan, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Castiglioni
authors.forename: Alessandro
authors.initials: A
authors.lastname: Verzini
authors.forename: Federico
authors.initials: F
authors.lastname: Pappalardo
authors.forename: Nicola
authors.initials: N
authors.lastname: Colangelo
authors.forename: Lucia
authors.initials: L
authors.lastname: Torracca
authors.forename: Alberto
authors.initials: A
authors.lastname: Zangrillo
authors.forename: Ottavio
authors.initials: O
authors.lastname: Alfieri
mesh_terms: D000368:Aged; D001021:Aortic Valve / Q000601:surgery*; D001803:Blood Transfusion / Q000706:statistics & numerical data; D015505:Chest Tubes; D004322:Drainage / Q000706:statistics & numerical data; D005112:Extracorporeal Circulation / Q000009:adverse effects; D005260:Female; D006349:Heart Valve Diseases / Q000097:blood / Q000601:surgery*; D019918:Heart Valve Prosthesis Implantation / Q000009:adverse effects; D006400:Hematocrit; D006801:Humans; D007362:Intensive Care Units; D007432:Intraoperative Period; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D019060:Minimally Invasive Surgical Procedures / Q000009:adverse effects; D009422:Nervous System Diseases / Q000209:etiology; D010976:Platelet Count; D011183:Postoperative Complications; D011184:Postoperative Period; D013997:Time Factors; D019209:Troponin C / Q000097:blood
chemical_list: D019209:Troponin C