The immune system: taming and unleashing cancer.
The immune system usually detects and destroys pre-malignant cells, which are cells that have initiated oncogenic transformation. To fulfill this role, the immune system must distinguish between normal and transformed cells rather than between self and non-self. A large body of novel research studies illuminates the close relation between immunosurveillance and oncogenesis, suggesting new strategies for reestablishing the immune response against established tumors.
Tesniere
Antoine
A
NSERM, Unit "Apoptosis, Cancer and Immunity," F-94805 Villejuif, France.
Zitvogel
Laurence
L
Kroemer
Guido
G
D000818:Animals; D006801:Humans; D007107:Immune System / Q000276:immunology / Q000502:physiology*; D008962:Models, Theoretical; D015166:Monitoring, Immunologic; D009369:Neoplasms / Q000276:immunology* / Q000628:therapy