title: Breaking proteins with mutations: threads and thresholds in evolution.
authors.forename: Jesse D
authors.initials: JD
authors.lastname: Bloom
authors.forename: Frances H
authors.initials: FH
authors.lastname: Arnold
authors.forename: Claus O
authors.initials: CO
authors.lastname: Wilke
mesh_terms: D004843:Epistasis, Genetic; D009154:Mutation; D011506:Proteins / Q000235:genetics*
chemical_list: D011506:Proteins