title: IL-6 immunoreactivity changes during aging in the polychaete Ophryotrocha labronica (Polychaeta: Dorvilleidae).
abstract: IL-6 is a pleiotropic pro-inflammatory cytokine thought to play a role in age physiology, even if its possible modulation by aging mechanisms has not been fully defined. In this paper, the morpho-functional modifications and IL-6 immunoreactivity during aging in a simple invertebrate model, Ophryotrocha labronica, are reported. The comparison between newly-hatched, juveniles, young adult and 3-month-old females showed significant differences in the nervous and genital systems. There is evidence of nerve cell loss and a decline in oocyte growth and maturation at the gonad level. Immunohistochemistry reveals a different distribution of IL-6-like molecules, and a decreased number of reactive nerve cells in the central nervous system of aged O. labronica associated to the induced morphological modifications.
authors.affiliation: Department of Animal Biology, University of Modena and Reggio Emilia, via Campi 213/D, Modena, Italy. franchini.antonella@unimore.it
authors.forename: A
authors.initials: A
authors.lastname: Franchini
authors.forename: E
authors.initials: E
authors.lastname: Ottaviani
mesh_terms: D000375:Aging / Q000276:immunology*; D000818:Animals; D017209:Apoptosis / Q000502:physiology; D002454:Cell Differentiation / Q000502:physiology; D048430:Cell Shape / Q000502:physiology; D005260:Female; D005836:Genitalia, Female / Q000166:cytology / Q000254:growth & development / Q000276:immunology; D007150:Immunohistochemistry; D015850:Interleukin-6 / Q000378:metabolism*; D009420:Nervous System / Q000166:cytology / Q000254:growth & development / Q000276:immunology; D009866:Oogenesis / Q000502:physiology; D011077:Polychaeta / Q000166:cytology / Q000276:immunology*
chemical_list: D015850:Interleukin-6