title: Effect of danofloxacin (Advocin A180) on goats affected with contagious caprine pleuropneumonia.
abstract: The efficacy of danofloxacin (Advocin A180) was evaluated for the treatment of contagious caprine pleuropneumonia (CCPP) caused by Mycoplasma capricolum subsp. capripneumoniae. Ten healthy Angora goats, confirmed free of CCPP, were exposed to clinically affected animals from a natural outbreak in Thrace, Turkey. After 14 days exposure, 8 goats showed pyrexia ( > or = 41 degrees C). Shortly after, the Angora goats were divided randomly into two groups. Five of these were injected with danofloxacin (6 mg/kg subcutaneously), which was repeated after 48 h; the five remaining animals received saline. Goats were monitored clinically and blood samples were collected for serology. Animals with severe disease were withdrawn from the trial. Goats completing the study were euthanized at day 42. Lung tissue and bronchial fluid were collected for mycoplasma isolation. All danofloxacin-treated goats showed resolution of clinical disease by the end of the trial. Two saline-treated goats failed to complete the study owing to CCPP. Danofloxacin-treated goats showed fewer lung lesions and had significantly lower combined clinical scores than saline controls (p < 0.001). Danofloxacin was found to be highly effective in the treatment of CCPP in goats.
authors.affiliation: Veterinary Control and Research Institute, Pendik, Istanbul, Turkey.
authors.forename: U
authors.initials: U
authors.lastname: Ozdemir
authors.forename: G R
authors.initials: GR
authors.lastname: Loria
authors.forename: K S
authors.initials: KS
authors.lastname: Godinho
authors.forename: R
authors.initials: R
authors.lastname: Samson
authors.forename: T G
authors.initials: TG
authors.lastname: Rowan
authors.forename: C
authors.initials: C
authors.lastname: Churchward
authors.forename: R D
authors.initials: RD
authors.lastname: Ayling
authors.forename: R A J
authors.initials: RA
authors.lastname: Nicholas
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D004196:Disease Outbreaks / Q000662:veterinary; D024841:Fluoroquinolones / Q000627:therapeutic use*; D015511:Goat Diseases / Q000188:drug therapy* / Q000453:epidemiology; D006041:Goats; D008168:Lung / Q000382:microbiology / Q000473:pathology; D008297:Male; D011002:Pleuropneumonia, Contagious / Q000188:drug therapy* / Q000453:epidemiology; D011897:Random Allocation; D016896:Treatment Outcome; D014421:Turkey / Q000453:epidemiology
chemical_list: D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones; C068581:danofloxacin