title: Beneficial effects of a three-month structured exercise training program on cardiopulmonary functional capacity in young women with polycystic ovary syndrome.
abstract: BACKGROUND
  Polycystic ovary syndrome (PCOS) is an endocrine disease closely related to several risk factors for cardiovascular disease. An impaired cardiopulmonary functional capacity was previously demonstrated in PCOS women. No data regarding the effects of a structured exercise training (ET) program on cardiopulmonary functional capacity in PCOS women are available.
  
  
  OBJECTIVE
  Our objective was to evaluate the effects of a 3-month ET program on cardiopulmonary functional capacity in young PCOS women.
  
  
  METHODS
  A prospective baseline-randomized clinical study was conducted at the University "Federico II" of Naples, School of Medicine (Italy).
  
  
  METHODS
  Ninety young overweight PCOS women were enrolled.
  
  
  METHODS
  Ninety young PCOS women were randomly subdivided into two groups, each composed of 45 subjects. The PCOS-T (trained) group underwent a 3-month structured ET program, whereas the PCOS-UnT (untrained) group did not. Hormonal and metabolic profiles and cardiopulmonary and exercise parameters were evaluated.
  
  
  RESULTS
  After 3-month ET, PCOS-T showed a significant improvement in peak oxygen consumption (+35.4%; P<0.001) and in maximal workload (+37.2%; P<0.001). In PCOS-T we also observed a significant reduction in body mass index (-4.5%; P<0.001) and in C-reactive protein (-10%; P<0.001), and a significant (P<0.001) improvement in insulin sensitivity indexes. After 3 months, no changes were observed in PCOS-UnT.
  
  
  CONCLUSIONS
  A 3-month structured ET program improves cardiopulmonary functional capacity in young PCOS women.
authors.affiliation: Department of Clinical Medicine, University Federico II of Naples, Italy.
authors.forename: Carlo
authors.initials: C
authors.lastname: Vigorito
authors.forename: Francesco
authors.initials: F
authors.lastname: Giallauria
authors.forename: Stefano
authors.initials: S
authors.lastname: Palomba
authors.forename: Teresa
authors.initials: T
authors.lastname: Cascella
authors.forename: Francesco
authors.initials: F
authors.lastname: Manguso
authors.forename: Rosa
authors.initials: R
authors.lastname: Lucci
authors.forename: Anna
authors.initials: A
authors.lastname: De Lorenzo
authors.forename: Domenico
authors.initials: D
authors.lastname: Tafuri
authors.forename: Gaetano
authors.initials: G
authors.lastname: Lombardi
authors.forename: Annamaria
authors.initials: A
authors.lastname: Colao
authors.forename: Francesco
authors.initials: F
authors.lastname: Orio
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D015992:Body Mass Index; D002784:Cholesterol / Q000097:blood; D015444:Exercise; D005260:Female; D006334:Heart Function Tests; D006801:Humans; D007328:Insulin / Q000097:blood; D008074:Lipoproteins / Q000097:blood; D050177:Overweight; D010101:Oxygen Consumption; D010809:Physical Fitness; D011085:Polycystic Ovary Syndrome / Q000503:physiopathology* / Q000534:rehabilitation; D012129:Respiratory Function Tests; D016896:Treatment Outcome; D014280:Triglycerides / Q000097:blood; D015431:Weight Loss
chemical_list: D001786:Blood Glucose; D007328:Insulin; D008074:Lipoproteins; D014280:Triglycerides; D002784:Cholesterol