title: Differential effects of undernourishment and nutritional rehabilitation on serum leptin levels in male and female rats.
abstract: Leptin, a peptide hormone, is secreted by adipose tissue and is crucial to the regulation of feeding behaviour. The present study has shown that both male and female rats which have been undernourished since day six of gestation, show significantly decreased serum leptin levels on postnatal day 12; but when undernourishment continues into adulthood, only males continue to show decreased leptin levels. If nutritional rehabilitation is implemented early enough in males, serum leptin levels recover and nearly reach levels found in control adult males. Undernutrition also has a long term effect on body weight in both sexes, but nutritional rehabilitation leads to some degree of body weight recovery varying with sex and the age at which rehabilitation was implemented. Undernutrition seems to affect different developmental processes in males than in females, with males being more vulnerable than females in so far as long-term effects on serum leptin levels.
authors.affiliation: Departamento de Psicobiología, Universidad Nacional de Educación a Distancia, C/Juan del Rosal, 10, 28040 Madrid, Spain.
authors.forename: Helena
authors.initials: H
authors.lastname: Pinos
authors.forename: Esperanza
authors.initials: E
authors.lastname: Ortega
authors.forename: Beatriz
authors.initials: B
authors.lastname: Carrillo
authors.forename: Mari Angeles
authors.initials: MA
authors.lastname: Pérez-Izquierdo
authors.forename: Paloma
authors.initials: P
authors.lastname: Collado
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D001835:Body Weight; D004970:Estrone / Q000097:blood; D005260:Female; D020738:Leptin / Q000097:blood*; D008297:Male; D044342:Malnutrition / Q000503:physiopathology*; D009752:Nutritional Status; D051381:Rats; D017208:Rats, Wistar; D012727:Sex Characteristics; D013739:Testosterone / Q000097:blood
chemical_list: D020738:Leptin; D004970:Estrone; D013739:Testosterone