Oxaliplatin-induced hemolytic anemia during adjuvant treatment of a patient with colon cancer: a case report.
We report the case of a 64-year-old patient who developed autoimmune hemolytic anemia with thrombocytopenia and acute renal failure shortly after the infusion of the 11th cycle of adjuvant chemotherapy with oxaliplatin, folinic acid and 5-fluorouracil (FOLFOX 4), and was successfully treated by means of plasmapheresis, corticosteroids and dialysis. To the best of our knowledge, only seven other cases have been described in the literature, but we believe this serious adverse event induced by oxaliplatin is more frequent than this would suggest.
Buti
Sebastiano
S
Oncology Division, University of Parma, Medical School, Parma, Italy. sebabuti@libero.it
Riccò
Matteo
M
Chiesa
Matteo Dalla
MD
Copercini
Bruno
B
Tomasello
Gianluca
G
Brighenti
Matteo
M
Passalacqua
Rodolfo
R
D058186:Acute Kidney Injury / Q000139:chemically induced / Q000150:complications; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000744:Anemia, Hemolytic, Autoimmune / Q000139:chemically induced* / Q000188:drug therapy / Q000628:therapy*; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001772:Blood Cell Count; D017024:Chemotherapy, Adjuvant; D003110:Colonic Neoplasms / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D009944:Organoplatinum Compounds / Q000009:adverse effects* / Q000627:therapeutic use; D000077150:Oxaliplatin; D010956:Plasmapheresis; D006435:Renal Dialysis
D000305:Adrenal Cortex Hormones; D000970:Antineoplastic Agents; D009944:Organoplatinum Compounds; D000077150:Oxaliplatin