title: Roles and interactions of usher 1 proteins in the outer retina.
abstract: Our studies demonstrate that harmonin and myosin VIIa are not localized in the same compartments in the mouse and human retinas, indicating that they do not interact in this organ, contrary to what has been shown in the inner ear. The enrichment of harmonin in the photoreceptor synapses indicates that this protein may form multiple complexes with others to maintain the synaptic structure or to mediate in the release of synaptic vesicles.
authors.affiliation: Department of Pharmacology, UCSD School of Medicine, La Jolla, CA 92092-0983, USA.
authors.forename: Concepción
authors.initials: C
authors.lastname: Lillo
authors.forename: Junko
authors.initials: J
authors.lastname: Kitamoto
authors.forename: David S
authors.initials: DS
authors.lastname: Williams
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000737:chemistry; D000818:Animals; D018797:Cell Cycle Proteins; D003598:Cytoskeletal Proteins; D004398:Dyneins / Q000737:chemistry / Q000502:physiology*; D006801:Humans; D007150:Immunohistochemistry; D051379:Mice; D008854:Microscopy, Electron; D016253:Microscopy, Immunoelectron; D000081412:Myosin VIIa; D009218:Myosins / Q000737:chemistry / Q000502:physiology*; D020419:Photoreceptor Cells, Vertebrate / Q000378:metabolism; D010857:Pigment Epithelium of Eye / Q000378:metabolism; D011485:Protein Binding; D017434:Protein Structure, Tertiary; D012160:Retina / Q000378:metabolism*; D052245:Usher Syndromes / Q000378:metabolism*
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D018797:Cell Cycle Proteins; D003598:Cytoskeletal Proteins; C000631455:MYO7A protein, human; C000631456:Myo7a protein, mouse; D000081412:Myosin VIIa; C118970:USH1C protein, human; D009218:Myosins; D004398:Dyneins