title: A voxel-based mouse for internal dose calculations using Monte Carlo simulations (MCNP).
abstract: Murine models are useful for targeted radiotherapy pre-clinical experiments. These models can help to assess the potential interest of new radiopharmaceuticals. In this study, we developed a voxel-based mouse for dosimetric estimates. A female nude mouse (30 g) was frozen and cut into slices. High-resolution digital photographs were taken directly on the frozen block after each section. Images were segmented manually. Monoenergetic photon or electron sources were simulated using the MCNP4c2 Monte Carlo code for each source organ, in order to give tables of S-factors (in Gy Bq-1 s-1) for all target organs. Results obtained from monoenergetic particles were then used to generate S-factors for several radionuclides of potential interest in targeted radiotherapy. Thirteen source and 25 target regions were considered in this study. For each source region, 16 photon and 16 electron energies were simulated. Absorbed fractions, specific absorbed fractions and S-factors were calculated for 16 radionuclides of interest for targeted radiotherapy. The results obtained generally agree well with data published previously. For electron energies ranging from 0.1 to 2.5 MeV, the self-absorbed fraction varies from 0.98 to 0.376 for the liver, and from 0.89 to 0.04 for the thyroid. Electrons cannot be considered as 'non-penetrating' radiation for energies above 0.5 MeV for mouse organs. This observation can be generalized to radionuclides: for example, the beta self-absorbed fraction for the thyroid was 0.616 for I-131; absorbed fractions for Y-90 for left kidney-to-left kidney and for left kidney-to-spleen were 0.486 and 0.058, respectively. Our voxel-based mouse allowed us to generate a dosimetric database for use in preclinical targeted radiotherapy experiments.
authors.affiliation: INSERM, U601, Nantes, F-44093, France.
authors.forename: A
authors.initials: A
authors.lastname: Bitar
authors.forename: A
authors.initials: A
authors.lastname: Lisbona
authors.forename: P
authors.initials: P
authors.lastname: Thedrez
authors.forename: C
authors.initials: C
authors.lastname: Sai Maurel
authors.forename: D
authors.initials: D
authors.lastname: Le Forestier
authors.forename: J
authors.initials: J
authors.lastname: Barbet
authors.forename: M
authors.initials: M
authors.lastname: Bardies
mesh_terms: D000818:Animals; D001822:Body Burden; D007668:Kidney / Q000528:radiation effects*; D018499:Linear Energy Transfer; D051379:Mice; D008819:Mice, Nude; D009010:Monte Carlo Method; D011868:Radioisotopes / Q000493:pharmacokinetics*; D011874:Radiometry / Q000379:methods*; D012062:Relative Biological Effectiveness; D012815:Signal Processing, Computer-Assisted; D013154:Spleen / Q000528:radiation effects*; D013961:Thyroid Gland / Q000528:radiation effects*; D014915:Whole-Body Counting
chemical_list: D011868:Radioisotopes