Structure-activity relationships of xanthocillin derivatives as thrombopoietin receptor agonist.
Xanthocillin derivatives, which show thrombopoietin receptor agonist activity, were synthesized through our developed method. Bioassay data suggest the importance of alkene geometry, the presence of substituents at the benzene ring that support hydrophobic character, and the moderate size of the molecule. One of the two isonitrile group of the natural product appears to be dispensable.
Yamaguchi
Takahiro
T
Department of Chemistry, School of Science and Engineering, Waseda University, 3-4-1 Ohkubo, Shinjyuku-ku, Tokyo 169-8555, Japan.
Miyake
Yumi
Y
Miyamura
Atsushi
A
Ishiwata
Norihisa
N
Tatsuta
Kuniaki
K
D002070:Butadienes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009570:Nitriles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D010636:Phenols / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D053628:Receptors, Thrombopoietin / Q000819:agonists*; D013329:Structure-Activity Relationship
D002070:Butadienes; D009570:Nitriles; D010636:Phenols; D053628:Receptors, Thrombopoietin