title: Effects of reaction rate of radical anion of a photosensitizer with molecular oxygen on the photosensitized DNA damage.
abstract: Based on the synthesis of DNA modified with photosensitizers, direct spectroscopic measurements of the hole transfer in DNA, and quantification of the yield of the DNA oxidative damage, the reaction rate of the radical anion of the photosensitizer was demonstrated to be critically important in determining the efficiency of photosensitized DNA damage.
authors.affiliation: The Institute of Scientific and Industrial Research (SANKEN), Osaka University, Mihogaoka 8-1, Ibaraki, Osaka 567-0047, Japan. kiyohiko@sanken.osaka-u.ac.jp
authors.forename: Kiyohiko
authors.initials: K
authors.lastname: Kawai
authors.forename: Yasuko
authors.initials: Y
authors.lastname: Osakada
authors.forename: Mamoru
authors.initials: M
authors.lastname: Fujitsuka
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Majima
mesh_terms: D000838:Anions / Q000737:chemistry; D001483:Base Sequence; D004249:DNA Damage; D005609:Free Radicals / Q000737:chemistry*; D010084:Oxidation-Reduction; D010100:Oxygen / Q000737:chemistry*; D010777:Photochemistry; D017319:Photosensitizing Agents / Q000737:chemistry*; D013057:Spectrum Analysis
chemical_list: D000838:Anions; D005609:Free Radicals; D017319:Photosensitizing Agents; D010100:Oxygen