title: Treatment of McLeod phenotype chronic granulomatous disease with reduced-intensity conditioning and unrelated-donor umbilical cord blood transplantation.
abstract: Patients with chronic granulomatous disease (CGD) complicated by antimycotics-refractory invasive aspergillosis have an extremely poor prognosis if they cannot undergo allogeneic hematopoietic stem cell transplantation from a suitable related donor while in good clinical condition. We successfully treated a 20-year-old man with very rare McLeod phenotype CGD with reduced-intensity conditioning and unrelated-donor umbilical cord blood transplantation. We postulate that reduced-intensity conditioning-allogeneic hematopoietic stem cell transplantation is a promising therapeutic strategy for patients with CGD even if only unrelated-donor umbilical cord blood is available.
authors.affiliation: Department of Pediatrics, Sapporo Medical University School of Medicine, Sapporo, Japan. nsuzuki@sapmed.ac.jp
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Suzuki
authors.forename: Naoki
authors.initials: N
authors.lastname: Hatakeyama
authors.forename: Masaki
authors.initials: M
authors.lastname: Yamamoto
authors.forename: Nobuo
authors.initials: N
authors.lastname: Mizue
authors.forename: Yuki
authors.initials: Y
authors.lastname: Kuroiwa
authors.forename: Minami
authors.initials: M
authors.lastname: Yoda
authors.forename: Junko
authors.initials: J
authors.lastname: Takahashi
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Tani
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Tsutsumi
mesh_terms: D000328:Adult; D001228:Aspergillosis; D036101:Cord Blood Stem Cell Transplantation / Q000379:methods*; D006105:Granulomatous Disease, Chronic / Q000150:complications / Q000628:therapy*; D006801:Humans; D008297:Male; D010641:Phenotype; D014019:Tissue Donors; D019172:Transplantation Conditioning / Q000379:methods*; D014184:Transplantation, Homologous; D016896:Treatment Outcome