Four new nonaoxygenated C18 dibenzocylcooctadiene lignans from Kadsura philippinensis.
Four new nona-oxygenated C18 dibenzocyclooctadiene lignans, kadsuphilins C-F (1-4), were isolated from the EtOAc soluble portion of the alcoholic extract of the aerial parts of Kadsura philippinensis. The structures of 1-4 were elucidated on the basis of extensive spectroscopic analyses, including 2D NMR (HMQC, HMBC, and NOESY) experiments, comparison of the spectral data with those of the related metabolites. The stereochemistries of the biphenyl and octadiene moieties were deduced from circular dichorism (CD) and the NOESY spectra, respectively. The in vitro antiplatelet aggregation activity of metabolites 1-4 also have been evaluated.
Shen
Ya-Ching
YC
School of Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan. ycshen@ntu.edu.tw
Lin
Yu-Chi
YC
Ahmed
Atallah F
AF
Cheng
Yuan-Bin
YB
Liaw
Chia-Ching
CC
Kuo
Yao-Haur
YH
D000438:Alcohols / Q000737:chemistry; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D002942:Circular Dichroism; D034242:Cyclooctanes / Q000032:analysis / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D032135:Kadsura / Q000737:chemistry*; D017705:Lignans / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry*; D010975:Platelet Aggregation Inhibitors / Q000378:metabolism; D013237:Stereoisomerism
D000438:Alcohols; D000972:Antineoplastic Agents, Phytogenic; D034242:Cyclooctanes; D017705:Lignans; D010936:Plant Extracts; D010975:Platelet Aggregation Inhibitors; C511097:dibenzocyclooctadiene; C510994:dibenzocyclooctadiene lignan