title: Densitometric analysis of the autogenous demineralized dentin matrix on the dental socket wound healing process in humans.
abstract: The aim of this study was to evaluate the effects of the autogenous demineralized dentin matrix (ADDM) on the third molar socket wound healing process in humans, using the guided bone regeneration technique and a polytetrafluoroethylene barrier (PTFE). Twenty-seven dental sockets were divided into three groups: dental socket (Control), dental socket with PTFE barrier (PTFE), and dental socket with ADDM slices associated to PTFE barrier (ADDM + PTFE). The dental sockets were submitted to radiographic bone densitometry analysis and statistical analysis on the 15th, 30th, 60th and 90th days using analysis of variance (ANOVA) and Tukey's test (p < or = 0.05). The radiographic analysis of the ADDM + PTFE group showed greater homogeneity of bone radiopacity than the Control group and the PTFE group, during all the observation times. The dentin matrix gradually disappeared from the dental socket during the course of the repair process, suggesting its resorption during the bone remodeling process. It was concluded that the radiographic bone density of the dental sockets treated with ADDM was similar to that of the surrounding normal bone on the 90th day. The ADDM was biocompatible with the bone tissue of the surgical wounds of human dental sockets. The radiographic analysis revealed that the repair process was discreetly faster in the ADDM + PTFE group than in the Control and PTFE groups, although the difference was not statistically significant. In addition, the radiographic image of the ADDM + PTFE group suggested that its bone architecture was better than that of the Control and PFTE groups.
authors.affiliation: Special Health Care Needs Association (ASPE).
authors.forename: Mônica Fernandes
authors.initials: MF
authors.lastname: Gomes
authors.forename: Paula Pinheiro de
authors.initials: PP
authors.lastname: Abreu
authors.forename: Aline Rose Cantarelli
authors.initials: AR
authors.lastname: Morosolli
authors.forename: Marcelo Marotta
authors.initials: MM
authors.lastname: Araújo
authors.forename: Maria das Graças Vilela
authors.initials: Md
authors.lastname: Goulart
mesh_terms: D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D001672:Biocompatible Materials; D015519:Bone Density / Q000502:physiology; D001857:Bone Matrix / Q000000981:diagnostic imaging; D001861:Bone Regeneration / Q000187:drug effects* / Q000502:physiology; D015921:Dental Implants / Q000592:standards; D003804:Dentin / Q000000981:diagnostic imaging; D005260:Female; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods*; D006801:Humans; D008297:Male; D008964:Molar, Third / Q000000981:diagnostic imaging; D011138:Polytetrafluoroethylene / Q000494:pharmacology*; D011859:Radiography; D023822:Tissue Engineering; D014081:Tooth Extraction; D020390:Tooth Socket / Q000000981:diagnostic imaging* / Q000187:drug effects / Q000601:surgery; D014945:Wound Healing / Q000187:drug effects* / Q000502:physiology
chemical_list: D001672:Biocompatible Materials; C093073:Demineralized Dentin Matrix; D015921:Dental Implants; D011138:Polytetrafluoroethylene