title: Alignment of a conjugated polymer onto amyloid-like protein fibrils.
abstract: The amyloid-like fibril is a biomolecular nanowire template of very high stability. Here we describe the coordination of a conjugated polyelectrolyte, poly(thiophene acetic acid) (PTAA), to bovine insulin fibrils with widths of <10 nm and lengths of up to more than 10 microm. Fibrils complexed with PTAA are aligned on surfaces through molecular combing and transfer printing. Single-molecule spectroscopy techniques are applied to chart spectral variation in the emission of these wires. When these results are combined with analysis of the polarization of the emitted light, we can conclude that the polymer chains are preferentially aligned along the fibrillar axis.
authors.affiliation: Biomolecular and Organic Electronics, IFM, Linköping University, Linköping, Sweden. anher@ifm.liu.se
authors.forename: Anna
authors.initials: A
authors.lastname: Herland
authors.forename: Per
authors.initials: P
authors.lastname: Björk
authors.forename: P Ralph
authors.initials: PR
authors.lastname: Hania
authors.forename: Ivan G
authors.initials: IG
authors.lastname: Scheblykin
authors.forename: Olle
authors.initials: O
authors.lastname: Inganäs
mesh_terms: D000085:Acetates / Q000737:chemistry*; D016229:Amyloid beta-Peptides / Q000737:chemistry*; D000818:Animals; D040761:Biomimetic Materials / Q000737:chemistry*; D002417:Cattle; D003460:Crystallization / Q000379:methods*; D046911:Macromolecular Substances / Q000737:chemistry; D008422:Materials Testing; D008968:Molecular Conformation; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure*; D036103:Nanotechnology / Q000379:methods*; D010316:Particle Size; D011108:Polymers / Q000737:chemistry; D013499:Surface Properties; D013876:Thiophenes / Q000737:chemistry*
chemical_list: D000085:Acetates; D016229:Amyloid beta-Peptides; D046911:Macromolecular Substances; D011108:Polymers; D013876:Thiophenes; C472956:poly(thiophene-3-acetic acid)