A light- and electron-microscope study of hepatocytes of rats fed different diets.
Ketogenic diets are used in the treatment of epilepsy in children refractory to drug therapy. This study identifies changes in liver morphology in rats fed four different diets: a normal rodent chow diet, a calorie-restricted high-fat (ketogenic) diet and each diet supplemented with clofibric acid. Hepatocytes of rats fed the ketogenic diet show many lipid droplets and these are reduced to control levels when clofibrate is present in the diet. Mitochondria are enlarged in the livers of rats fed the ketogenic diet and further enlarged if clofibrate is present. Alterations in the appearance or numbers of other organelles are also found.
Eagles
Douglas A
DA
Department of Biology, Georgetown University, Box 571229, Washington, DC 20057-1229, USA. eaglesd@georgetown.edu
Chapman
George B
GB
D000821:Animal Feed; D000818:Animals; D002995:Clofibric Acid / Q000494:pharmacology; D004038:Diet, Reducing; D019587:Dietary Supplements; D022781:Hepatocytes / Q000166:cytology* / Q000187:drug effects / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D051381:Rats; D017207:Rats, Sprague-Dawley
D002995:Clofibric Acid