Transplantation in chronic obstructive pulmonary disease.
Lung transplantation is a surgical option for patients who fail optimization of medical treatment for the severe symptoms that result from COPD. This review will discuss patient selection, transplant listing, and the surgical technique for transplantation in COPD. Furthermore, it will describe transplant outcomes and its effects on recipient survival, pulmonary function, exercise capacity, respiratory muscle function, and quality of life. The respective roles of transplantation and lung volume reduction surgery as therapies for advanced disease will be outlined.
Patel
Namrata
N
Division of Pulmonary and Critical Care Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA. pateln@tuhs.temple.edu
Criner
Gerard J
GJ
D000465:Algorithms; D001999:Bronchoscopy; D000075202:Contraindications; D003550:Cystic Fibrosis / Q000401:mortality; D049673:History, 20th Century; D006801:Humans; D016040:Lung Transplantation / Q000266:history; D018579:Patient Selection; D011013:Pneumonectomy; D029424:Pulmonary Disease, Chronic Obstructive / Q000503:physiopathology / Q000601:surgery*; D011656:Pulmonary Emphysema / Q000401:mortality; D011658:Pulmonary Fibrosis / Q000401:mortality; D011659:Pulmonary Gas Exchange; D011788:Quality of Life; D016896:Treatment Outcome