title: Expression of AMH in female fetal intersex gonads in the bovine.
abstract: Anti Müllerian Hormone, AMH, is believed to be the main agent in the freemartin syndrome. Supposing an active role of freemartin gonads in AMH secretion, in the present study, we aimed at investigating the presence and the localization of AMH producing cells either in fetal or in adult freemartin gonads. Our finding of positive AMH cells in a 26-week-old freemartin fetus indicates an active role of masculinized freemartin gonads in AMH secretion. However, the positive reaction, limited to few cells grouped in 'nests' in proximity to testis cord-like structures, supports a chimeric origin of such cells, migrated from the male co-twin. No adult freemartin, irrespective from the degree of masculinization, showed any AMH positive cell.
authors.affiliation: Department of Experimental Veterinary Science, University of Padua, Agripolis, 35020 Legnaro (PD), Italy.
authors.forename: G
authors.initials: G
authors.lastname: Cabianca
authors.forename: A
authors.initials: A
authors.lastname: Rota
authors.forename: B
authors.initials: B
authors.lastname: Cozzi
authors.forename: C
authors.initials: C
authors.lastname: Ballarin
mesh_terms: D000818:Animals; D054304:Anti-Mullerian Hormone; D002417:Cattle / Q000196:embryology* / Q000378:metabolism; D002454:Cell Differentiation; D005260:Female; D005333:Fetus; D005611:Freemartinism / Q000196:embryology* / Q000378:metabolism; D006023:Glycoproteins / Q000378:metabolism*; D007150:Immunohistochemistry / Q000662:veterinary; D008297:Male; D010053:Ovary / Q000378:metabolism; D011247:Pregnancy; D013735:Testicular Hormones / Q000378:metabolism*; D013737:Testis / Q000378:metabolism
chemical_list: D006023:Glycoproteins; D013735:Testicular Hormones; D054304:Anti-Mullerian Hormone