title: Optoacoustic imaging of absorbing objects in a turbid medium: ultimate sensitivity and application to breast cancer diagnostics.
abstract: One of the major medical applications of optoacoustic (OA) tomography is in the diagnostics of early-stage breast cancer. A numerical approach was developed to characterize the following parameters of an OA imaging system: resolution, maximum depth at which the tumor can be detected, and image contrast. The parameters of the 64-element focused array transducer were obtained. The results of numerical modeling were compared with known analytical solutions and further validated by phantom experiments. The OA images of a 3 mm piece of bovine liver immersed in diluted milk at various depths were obtained. Based on the results of modeling, a signal filtering algorithm for OA image contrast enhancement has been proposed.
authors.affiliation: Faculty of Physics, Moscow State University, Moscow, Russia. t_hokhlova@ilc.edu.ru
authors.forename: Tatiana D
authors.initials: TD
authors.lastname: Khokhlova
authors.forename: Ivan M
authors.initials: IM
authors.lastname: Pelivanov
authors.forename: Victor V
authors.initials: VV
authors.lastname: Kozhushko
authors.forename: Alexei N
authors.initials: AN
authors.lastname: Zharinov
authors.forename: Vladimir S
authors.initials: VS
authors.lastname: Solomatin
authors.forename: Alexander A
authors.initials: AA
authors.lastname: Karabutov
mesh_terms: D000162:Acoustics; D000465:Algorithms; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000473:pathology; D003198:Computer Simulation; D006801:Humans; D007089:Image Enhancement; D015233:Models, Statistical; D008962:Models, Theoretical; D055095:Optics and Photonics; D012680:Sensitivity and Specificity; D012984:Software; D014054:Tomography / Q000379:methods*