title: Longitudinal survey of knockdown resistance to pyrethroid (kdr) in Mali, West Africa, and evidence of its emergence in the Bamako form of Anopheles gambiae s.s.
abstract: Studies aimed at monitoring the spread of knockdown resistance to pyrethroids (kdr) in time and space are particularly useful for detecting barriers to gene flow among the chromosomal and molecular forms of Anopheles gambiae. We used a recently developed polymerase chain reaction assay to estimate changes in kdr frequency that occurred in several mixed-form populations from Mali, West Africa, in the past decade. We found that the kdr allele significantly increased in frequency in most populations but was still absent from the M molecular form. Importantly, within the S molecular form, kdr was detected for the first time in the Bamako chromosomal form. These results provide important insights on the patterns of spread and emergence of pyrethroid knockdown resistance in West Africa.
authors.affiliation: Department of Entomology, University of California Davis, Davis, California 93648, USA. f.tripet@biol.keele.ac.uk
authors.forename: Frederic
authors.initials: F
authors.lastname: Tripet
authors.forename: Jennifer
authors.initials: J
authors.lastname: Wright
authors.forename: Anthon
authors.initials: A
authors.lastname: Cornel
authors.forename: Abdrahamane
authors.initials: A
authors.lastname: Fofana
authors.forename: Rory
authors.initials: R
authors.lastname: McAbee
authors.forename: Claudio
authors.initials: C
authors.lastname: Meneses
authors.forename: Lisa
authors.initials: L
authors.lastname: Reimer
authors.forename: Michel
authors.initials: M
authors.lastname: Slotman
authors.forename: Tara
authors.initials: T
authors.lastname: Thiemann
authors.forename: Guimogo
authors.initials: G
authors.lastname: Dolo
authors.forename: Sekou
authors.initials: S
authors.lastname: Traoré
authors.forename: Gregory
authors.initials: G
authors.lastname: Lanzaro
mesh_terms: D000483:Alleles; D000818:Animals; D000852:Anopheles / Q000187:drug effects* / Q000235:genetics*; D005260:Female; D007305:Insecticide Resistance / Q000235:genetics*; D008302:Mali; D009032:Mosquito Control; D011722:Pyrethrins / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D011722:Pyrethrins