title: Increase of multiple pregnancies caused by ovulation induction with gonadotropin in combination with metformin in infertile women with polycystic ovary syndrome.
abstract: Metformin appears to be an effective medicine to induce ovulation in women with polycystic ovary syndrome and insulin resistance. After the introduction of metformin treatment for such cases, the use of gonadotropin in combination with metformin significantly increased the incidence of multiple pregnancies.
authors.affiliation: Department of Obstetrics and Gynecology, School of Medicine, Jichi Medical University, Tochigi, Japan. sibahara@jichi.ac.jp <sibahara@jichi.ac.jp>
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Shibahara
authors.forename: Kumiko
authors.initials: K
authors.lastname: Kikuchi
authors.forename: Yuki
authors.initials: Y
authors.lastname: Hirano
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Suzuki
authors.forename: Satoru
authors.initials: S
authors.lastname: Takamizawa
authors.forename: Mitsuaki
authors.initials: M
authors.lastname: Suzuki
mesh_terms: D000328:Adult; D004359:Drug Therapy, Combination; D005260:Female; D006062:Gonadotropins / Q000627:therapeutic use*; D006801:Humans; D007247:Infertility, Female / Q000150:complications*; D008687:Metformin / Q000627:therapeutic use*; D011085:Polycystic Ovary Syndrome / Q000150:complications*; D011247:Pregnancy; D018873:Pregnancy Rate; D011272:Pregnancy, Multiple / Q000187:drug effects / Q000706:statistics & numerical data*
chemical_list: D006062:Gonadotropins; D008687:Metformin