title: Oxaliplatin-induced hemolytic anemia during adjuvant treatment of a patient with colon cancer: a case report.
abstract: We report the case of a 64-year-old patient who developed autoimmune hemolytic anemia with thrombocytopenia and acute renal failure shortly after the infusion of the 11th cycle of adjuvant chemotherapy with oxaliplatin, folinic acid and 5-fluorouracil (FOLFOX 4), and was successfully treated by means of plasmapheresis, corticosteroids and dialysis. To the best of our knowledge, only seven other cases have been described in the literature, but we believe this serious adverse event induced by oxaliplatin is more frequent than this would suggest.
authors.affiliation: Oncology Division, University of Parma, Medical School, Parma, Italy. sebabuti@libero.it
authors.forename: Sebastiano
authors.initials: S
authors.lastname: Buti
authors.forename: Matteo
authors.initials: M
authors.lastname: Riccò
authors.forename: Matteo Dalla
authors.initials: MD
authors.lastname: Chiesa
authors.forename: Bruno
authors.initials: B
authors.lastname: Copercini
authors.forename: Gianluca
authors.initials: G
authors.lastname: Tomasello
authors.forename: Matteo
authors.initials: M
authors.lastname: Brighenti
authors.forename: Rodolfo
authors.initials: R
authors.lastname: Passalacqua
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced / Q000150:complications; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000744:Anemia, Hemolytic, Autoimmune / Q000139:chemically induced* / Q000188:drug therapy / Q000628:therapy*; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001772:Blood Cell Count; D017024:Chemotherapy, Adjuvant; D003110:Colonic Neoplasms / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D009944:Organoplatinum Compounds / Q000009:adverse effects* / Q000627:therapeutic use; D000077150:Oxaliplatin; D010956:Plasmapheresis; D006435:Renal Dialysis
chemical_list: D000305:Adrenal Cortex Hormones; D000970:Antineoplastic Agents; D009944:Organoplatinum Compounds; D000077150:Oxaliplatin