Increased isoprostane and prostaglandin are prominent in neurons in Alzheimer disease.
BACKGROUND
Inflammation and oxidative stress are both involved in the pathogenesis of Alzheimer disease and have been shown to be reciprocally linked. One group of molecules that have been directly associated with inflammation and the production of free radicals are the prostaglandin 13,14-dihydro 15-keto PGF2alpha and the isoprostane 8-iso-PGF2alpha.


RESULTS
To further delineate the role of inflammatory and oxidative parameters in Alzheimer disease, in this study we evaluated the amount and localization of 13,14-dihydro 15-keto PGF2alpha and 8-iso-PGF2alpha in hippocampal post mortem tissue samples from age-matched Alzheimer disease and control patients. Our results demonstrate increased levels of 13,14-dihydro 15-keto PGF2alpha and 8-iso-PGF2alpha in the hippocampal pyramidal neurons of Alzheimer disease patients when compared to control patients.


CONCLUSIONS
These data not only support the shared mechanistic involvement of free radical damage and inflammation in Alzheimer disease, but also indicate that multiple pathogenic "hits" are likely necessary for both the development and propagation of Alzheimer disease.
Casadesus
Gemma
G
Department of Neuroscience, Case Western Reserve University, Cleveland, Ohio, USA. gxc40@case.edu
Smith
Mark A
MA
Basu
Samar
S
Hua
Jing
J
Capobianco
Dae E
DE
Siedlak
Sandra L
SL
Zhu
Xiongwei
X
Perry
George
G