A pilot study on the off-label use of valproic acid to treat adenomyosis.
Following on the heels of the discovery that endometriosis is an epigenetic disease, we conducted a pilot study on the off-label use of valproic acid to treat adenomyosis. We found that by the end of the 3-month treatment, all three recruited patients reported complete disappearance of dysmenorrhea, with an average of one-third reduction in uterus size.
Liu
Xishi
X
Department of Gynecology, Shanghai Obstetrics and Gynecology Hospital, Fudan University, Shanghai, China. lxsdoc@hotmail.com
Guo
Sun-Wei
SW
D000284:Administration, Oral; D000328:Adult; D000700:Analgesics / Q000008:administration & dosage / Q000627:therapeutic use*; D004348:Drug Labeling; D004412:Dysmenorrhea / Q000188:drug therapy / Q000201:enzymology / Q000209:etiology* / Q000473:pathology; D004715:Endometriosis / Q000150:complications / Q000188:drug therapy* / Q000201:enzymology / Q000473:pathology; D004791:Enzyme Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use*; D005240:Feasibility Studies; D005260:Female; D056572:Histone Deacetylase Inhibitors; D006801:Humans; D009929:Organ Size; D010147:Pain Measurement; D017699:Pelvic Pain / Q000188:drug therapy / Q000201:enzymology / Q000209:etiology* / Q000473:pathology; D010865:Pilot Projects; D016896:Treatment Outcome; D014599:Uterus / Q000187:drug effects* / Q000201:enzymology / Q000473:pathology; D014635:Valproic Acid / Q000008:administration & dosage / Q000627:therapeutic use*
D000700:Analgesics; D004791:Enzyme Inhibitors; D056572:Histone Deacetylase Inhibitors; D014635:Valproic Acid