title: Does ondansetron or granisetron prevent subarachnoid morphine-induced pruritus after cesarean delivery?
abstract: BACKGROUND
  We compared the efficacy of granisetron and ondansetron for the prevention of subarachnoid morphine-induced pruritus after cesarean delivery.
  
  
  METHODS
  The incidence of pruritus was assessed in parturients who were randomly allocated into Group G (granisetron 3 mg IV, n = 45), Group O (ondansetron 8 mg IV, n = 42), and Group S (saline IV, n = 42).
  
  
  RESULTS
  The incidence of pruritus was not significantly different among the 3 groups (86.6% in Group S, 83.3% in Group O, and 88% in the Group G).
  
  
  CONCLUSIONS
  Neither prophylactic ondansetron nor granisetron reduced the incidence of subarachnoid morphine-induced pruritus when compared with the saline group.
authors.affiliation: Department of Anesthesiology, American University of Beirut Medical center, Beirut, Lebanon. ss01@aub.edu.lb
authors.forename: Sahar M
authors.initials: SM
authors.lastname: Siddik-Sayyid
authors.forename: Marie T
authors.initials: MT
authors.lastname: Aouad
authors.forename: Samar K
authors.initials: SK
authors.lastname: Taha
authors.forename: Mireille S
authors.initials: MS
authors.lastname: Azar
authors.forename: Mona A
authors.initials: MA
authors.lastname: Hakki
authors.forename: Romeo N
authors.initials: RN
authors.lastname: Kaddoum
authors.forename: Viviane G
authors.initials: VG
authors.lastname: Nasr
authors.forename: Vanda G
authors.initials: VG
authors.lastname: Yazbek
authors.forename: Anis S
authors.initials: AS
authors.lastname: Baraka
mesh_terms: D000328:Adult; D000982:Antipruritics / Q000494:pharmacology / Q000627:therapeutic use*; D002585:Cesarean Section; D005260:Female; D017829:Granisetron / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D007278:Injections, Spinal; D009020:Morphine / Q000009:adverse effects* / Q000494:pharmacology; D017294:Ondansetron / Q000494:pharmacology / Q000627:therapeutic use*; D011247:Pregnancy; D011537:Pruritus / Q000139:chemically induced* / Q000453:epidemiology / Q000517:prevention & control*; D013346:Subarachnoid Space / Q000187:drug effects* / Q000502:physiology
chemical_list: D000982:Antipruritics; D017829:Granisetron; D009020:Morphine; D017294:Ondansetron