title: Testing Hypotheses about Linkage Disequilibrium with Multiple Alleles.
abstract: For loci with multiple alleles, hypotheses about linkage disequilibrium may be tested on the complete set of gametic data, or on various collapsed sets of data. Collapsing data into a few alleles at each locus can change the power of the tests, as implied in a recent paper by Zouros, Golding and Mackay (1977). We show that the nature of such changes can be found from properties of the noncentral chi-square distribution, and that the magnitude and direction of these changes depend on the levels of linkage disequilibria, allelic frequencies and degrees of freedom.
authors.affiliation: Department of Statistics, North Carolina State University, P. 0. Box 5457, Raleigh, North Carolina 27607.
authors.forename: B S
authors.initials: BS
authors.lastname: Weir
authors.forename: C C
authors.initials: CC
authors.lastname: Cockerham