title: Osteosarcoma and acromegaly: a case report and review of the literature.
abstract: A 72-yr-old acromegalic man, who presented with pain in the left femur, was found to have a metastatic osteosarcoma. Only three cases describing the coexistence of acromegaly and osteosarcoma have been reported by the literature. As the patient didn't have other risk factors for osteosarcoma, the hypothesis that accelerated rate of bone turnover caused by long-term exposure to high GH and IGF-I could act as a predisposing factor in the development of this malignant bone tumor is discussed.
authors.affiliation: Division of Endocrinology, Department of Internal Medicine, Clementino Fraga Filho University Hospital/Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
authors.forename: G A B
authors.initials: GA
authors.lastname: Lima
authors.forename: E M S
authors.initials: EM
authors.lastname: Gomes
authors.forename: R C
authors.initials: RC
authors.lastname: Nunes
authors.forename: L
authors.initials: L
authors.lastname: Vieira Neto
authors.forename: A P A V
authors.initials: AP
authors.lastname: Sieiro
authors.forename: E P
authors.initials: EP
authors.lastname: Brabo
authors.forename: M R
authors.initials: MR
authors.lastname: Gadelha
mesh_terms: D000172:Acromegaly / Q000150:complications*; D000368:Aged; D001859:Bone Neoplasms / Q000556:secondary; D017809:Fatal Outcome; D005266:Femoral Neoplasms / Q000209:etiology*; D006801:Humans; D008297:Male; D012516:Osteosarcoma / Q000209:etiology* / Q000556:secondary