title: Tuberculous cranial pachymeningitis.
abstract: We describe two immunocompetent patients with tuberculous cranial pachymeningitis. Both patients underwent biopsy after focal dural thickening was identified on MRI. Histopathologic examination of tissue revealed necrotizing granulomatous inflammation. PCR for Mycobacterium tuberculosis DNA was negative on CSF but positive on tissue. Both patients responded to antituberculous therapy. Although uncommon as a cause of cranial pachymeningitis, tuberculosis should be considered, since it responds well to treatment.
authors.affiliation: Department of Neurology, Royal Prince Alfred Hospital, NSW, Australia. matthewt@icn.usyd.edu.au
authors.forename: M J
authors.initials: MJ
authors.lastname: Thurtell
authors.forename: A B R
authors.initials: AB
authors.lastname: Keed
authors.forename: M
authors.initials: M
authors.lastname: Yan
authors.forename: T
authors.initials: T
authors.lastname: Gottlieb
authors.forename: J M
authors.initials: JM
authors.lastname: Spies
authors.forename: G M
authors.initials: GM
authors.lastname: Halmagyi
mesh_terms: D000328:Adult; D000995:Antitubercular Agents / Q000627:therapeutic use; D004388:Dura Mater / Q000000981:diagnostic imaging* / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011859:Radiography; D014390:Tuberculosis, Meningeal / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000473:pathology*
chemical_list: D000995:Antitubercular Agents