Safety of a combination diphtheria, tetanus toxoid, acellular pertussis, hepatitis B, and inactivated polio vaccine coadministered with a 7-valent pneumococcal conjugate vaccine and a Haemophilus influenzae type b conjugate vaccine.
The safety of DTaP-HepB-IPV vaccine coadministered with PCV and Hib was compared with separate administration of DTaP, HepB, IPV, Hib, and PCV at 2, 4, and 6 months of age. Healthy 2-month-old infants (N=1008) were randomized to the two groups. Following dose 1, there was no significant difference between the groups in the incidence of fever >101.3 degrees F. After each dose, the incidence of any fever (> or =100.4 degrees F) was significantly higher in the Combination Vaccine Group. The rate of fever >103.1 degrees F was < or =1.4% in both groups after any of the doses. Medical advice visits for fever were infrequent in both groups (< or =1.2%). DTaP-HepB-IPV was safe and well tolerated when coadministered with PCV and Hib.
Partridge
Susan
S
UCLA School of Medicine, 1124 W Carson Street, LIU Research Bldg, Torrance, CA 90502, USA. patridge@humc.edu
Alvey
Justin
J
Bernstein
Henry
H
Blatter
Mark
M
Bottenfield
Gerald
G
Guerrero
Juan
J
Senders
Shelly D
SD
Schuerman
Lode
L
Cheuvart
Brigitte
B
Holmes
Sandra J
SJ
D016667:Bacterial Capsules; D015721:Diphtheria-Tetanus-Pertussis Vaccine / Q000009:adverse effects*; D005260:Female; D005334:Fever; D018073:Haemophilus Vaccines / Q000008:administration & dosage / Q000009:adverse effects*; D017325:Hepatitis B Vaccines / Q000009:adverse effects*; D000069443:Heptavalent Pneumococcal Conjugate Vaccine; D006801:Humans; D007223:Infant; D008297:Male; D022401:Meningococcal Vaccines / Q000008:administration & dosage / Q000009:adverse effects*; D022242:Pneumococcal Vaccines / Q000008:administration & dosage / Q000009:adverse effects*; D011054:Poliovirus Vaccine, Inactivated / Q000008:administration & dosage / Q000009:adverse effects*; D011135:Polysaccharides, Bacterial / Q000008:administration & dosage / Q000009:adverse effects*; D018074:Vaccines, Conjugate / Q000008:administration & dosage / Q000009:adverse effects
D015721:Diphtheria-Tetanus-Pertussis Vaccine; D018073:Haemophilus Vaccines; C044237:Haemophilus influenzae type b polysaccharide vaccine; D017325:Hepatitis B Vaccines; D000069443:Heptavalent Pneumococcal Conjugate Vaccine; D022401:Meningococcal Vaccines; D022242:Pneumococcal Vaccines; D011054:Poliovirus Vaccine, Inactivated; D011135:Polysaccharides, Bacterial; D018074:Vaccines, Conjugate; C122182:diphtheria-tetanus-acellular pertussis-Hib-hepatitis B vaccine