title: Synthesis and structure evaluation of a novel cantharimide and its cytotoxicity on SK-Hep-1 hepatoma cells.
abstract: A remarkable control of the potency of cantharimide is described based on the electronic properties of functional group and it exhibits a relatively less toxic effect to the non-malignant hematological disorder bone marrow cells.
authors.affiliation: Lo Ka Chung Centre for Natural Anti-Cancer Drug Development, Institute of Molecular Technology for Drug Discovery and Synthesis, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong, PR China.
authors.forename: Stanton Hon Lung
authors.initials: SH
authors.lastname: Kok
authors.forename: Chung Hin
authors.initials: CH
authors.lastname: Chui
authors.forename: Wing Sze
authors.initials: WS
authors.lastname: Lam
authors.forename: Jien
authors.initials: J
authors.lastname: Chen
authors.forename: Fung Yi
authors.initials: FY
authors.lastname: Lau
authors.forename: Raymond Siu Ming
authors.initials: RS
authors.lastname: Wong
authors.forename: Gregory Yin Ming
authors.initials: GY
authors.lastname: Cheng
authors.forename: Paul Bo San
authors.initials: PB
authors.lastname: Lai
authors.forename: Thomas Wai Tong
authors.initials: TW
authors.lastname: Leung
authors.forename: Michael Wing Yiu
authors.initials: MW
authors.lastname: Yu
authors.forename: Johnny Cheuk On
authors.initials: JC
authors.lastname: Tang
authors.forename: Albert Sun Chi
authors.initials: AS
authors.lastname: Chan
mesh_terms: D000970:Antineoplastic Agents; D001854:Bone Marrow Cells / Q000187:drug effects; D002193:Cantharidin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000633:toxicity*; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy* / Q000473:pathology; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D004583:Electrons; D006801:Humans; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D002193:Cantharidin