Interferon lambda-1 (IFN-lambda1/IL-29) induces ELR(-) CXC chemokine mRNA in human peripheral blood mononuclear cells, in an IFN-gamma-independent manner.
Interferon lambda-1 (IFN-lambda1), the prototype Type-III interferon, has antiviral functions similar to those of the Type-I interferons, IFN-alpha and IFN-beta. However, IFN-lambda1 is capable of signaling through almost all STAT molecules and so it is possible that it may have novel immunoregulatory functions in addition to antiviral ones. From a range of chemokines tested, IFN-lambda1 elevated mRNA levels of only 'Monokine induced by IFN-gamma' (MIG/CXCL9), 'IFN-gamma inducible protein-10' (IP-10/CXCL10) and 'IFN-gamma inducible T-cell alpha chemoattractant' (I-TAC/CXCL11) from human peripheral blood mononuclear cells. As their names suggest, these chemokines are also induced by IFN-gamma, the only member of the Type-II interferon family. This action of IFN-lambda1 did not depend on intermediate induction of IFN-gamma and is therefore, likely to be independent of IFN-gamma. Further, our results suggest that donors responded to IFN-lambda1 stimulation either 'early' or 'late'. Overall the action of IFN-lambda1 was similar to that previously reported for IFN-gamma and may invite more detailed investigation of the role of IFN-lambda1 at the innate/adaptive interface.
Pekarek
V
V
HUMIGEN, The Institute for Genetic Immunology, Hamilton, NJ 08690-3303, USA.
Srinivas
S
S
Eskdale
J
J
Gallagher
G
G
D019743:Chemokines, CXC / Q000235:genetics / Q000378:metabolism*; D016207:Cytokines / Q000378:metabolism*; D017931:DNA Primers; D005786:Gene Expression Regulation / Q000235:genetics*; D006801:Humans; D007371:Interferon-gamma / Q000378:metabolism; D007372:Interferons; D007378:Interleukins / Q000378:metabolism*; D007963:Leukocytes, Mononuclear / Q000378:metabolism; D016133:Polymerase Chain Reaction; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism*; D000095022:Interferon Lambda
D019743:Chemokines, CXC; D016207:Cytokines; D017931:DNA Primers; D007371:Interferon-gamma; D007372:Interferons; D007378:Interleukins; D012333:RNA, Messenger; C000624353:interferon-lambda, human; D000095022:Interferon Lambda