title: Evaluation of organ distribution of microcystins in the freshwater phytoplanktivorous fish Hypophthalmichthys molitrix.
abstract: To evaluate the public health risk of exposure to microcystins in fish food in China, the distribution pattern of microcystin-LR and microcystin-RR in various organs (liver, intestine, kidney, muscle and lipid) of the dominant freshwater phytoplanktivorous fish Hypophthalmichthys molitrix in Hangzhou, China's Tiesha River was investigated with the method of HPLC-ESI-MS analysis. The distribution of microcystins was different in the fish organs and the major total microcystins (microcystin-LR and microcystin-RR) were present in the intestines (6.49 micro g/g fresh weight), followed by the livers (4.52 micro g/g fresh weight) and the muscles (2.86 micro g/g fresh weight). Microcystins were detected in kidneys (1.35 micro g/g fresh weight), but not detected in lipid. The results suggested that the mean daily intake from fish was 0.03 micro g/kg body weight which was very close to the recommended WHO tolerable daily intake (TDI) level of 0.04 micro g/kg body weight per day, and local people were warned they may have health risk if they consumed fish from the river.
authors.affiliation: School of Environmental and Resource Sciences, Zhejiang University, Hangzhou, China.
authors.forename: Hang-jun
authors.initials: HJ
authors.lastname: Zhang
authors.forename: Jian-ying
authors.initials: JY
authors.lastname: Zhang
authors.forename: Ye
authors.initials: Y
authors.lastname: Hong
authors.forename: Ying-xu
authors.initials: YX
authors.lastname: Chen
mesh_terms: D000818:Animals; D002347:Carps / Q000378:metabolism* / Q000469:parasitology; D005618:Fresh Water / Q000032:analysis* / Q000469:parasitology; D052998:Microcystins / Q000378:metabolism*; D009928:Organ Specificity; D010839:Phytoplankton / Q000378:metabolism; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D014018:Tissue Distribution; D014874:Water Pollutants, Chemical / Q000032:analysis*
chemical_list: D052998:Microcystins; D014874:Water Pollutants, Chemical