Diterpenes and synthetic derivatives from Viguiera aspillioides with trypanomicidal activity.
The dichloromethane extract of the tuberous roots of Viguiera aspillioides was tested in vitro against T. cruzi and then investigated in order to identify its active compounds, which were the known diterpenes (-)-ent-kaur-16-en-19-oic acid, (-)-trachyloban-19-oic acid, and (-)-kauran-16alpha-ol. Synthetic derivatives of the acidic compounds were obtained and tested; one of them, (-)-kaur-16-en-19-ol, was also active. Their IC50 are given.
da Costa
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Departamento de Física da Saúde, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de Sã Paulo, Avenida do Café s/n, 14040-903, Ribeirão Preto-SP, Brazil.
Albuquerque
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Vichnewski
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