title: Bilateral massive bloody pleurisy complicated by angiosarcoma.
abstract: We report a case of angiosarcoma complicated by bilateral massive bloody pleurisy (hematocrit of 7.2%) in an 83-year-old woman. An autopsy revealed hemorrhagic tumors infiltrating both the diaphragm and serosal surface of the peritoneum. Histological examination confirmed an anastomosing vascular channel pattern of the tumor cells with characteristic immunohistochemical findings for angiosarcoma, such as positive staining for vimentin, CD31, CD34, D2-40, and factor VIII-related antigen. The tumor was thought to have originated from a small vessel on the serosal surface of the duodenum. We also reviewed cases of hemothorax associated with angiosarcoma, which suggested that primary or metastatic pleural angiosarcoma should be considered a cause of spontaneous hemothorax, especially in patients with bilateral and/or intractable hemothorax.
authors.affiliation: Division of Respiratory Medicine, Tokyo Metropolitan Geriatric Hospital.
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Moriya
authors.forename: Tomonori
authors.initials: T
authors.lastname: Sugawara
authors.forename: Munefusa
authors.initials: M
authors.lastname: Arai
authors.forename: Yasunari
authors.initials: Y
authors.lastname: Tsuda
authors.forename: Koji
authors.initials: K
authors.lastname: Uchida
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Noguchi
authors.forename: Tomio
authors.initials: T
authors.lastname: Arai
authors.forename: Hideki
authors.initials: H
authors.lastname: Takahashi
mesh_terms: D000369:Aged, 80 and over; D017809:Fatal Outcome; D005260:Female; D006394:Hemangiosarcoma / Q000473:pathology*; D006491:Hemothorax / Q000209:etiology*; D006801:Humans; D007414:Intestinal Neoplasms / Q000473:pathology*; D010998:Pleurisy / Q000209:etiology*