title: [Effect of insulin-like growth factor and its receptor-I antibody on growth of human adrenocortical carcinoma SW-13 cell lines in vitro].
abstract: OBJECTIVE
  To evaluate the effect of insulin-like growth factor (IGF) and its receptor-I antibody on the growth of human adrenocortical carcinoma SW-13 cell line in vitro.
  
  
  METHODS
  The growth curves of SW-13 cell treated with IGF and its receptor-I antibody were obtained by means of MTT assay. The effects of the two agents, added either alone or in combination at different concentrations, on the cell growth were evaluated.
  
  
  RESULTS
  IGF significantly promoted proliferation of SW-13 cells, and its effect was positively correlated with its concentrations (P<0.05). IGF receptor-I antibody inhibited the effect of insulin-like growth factor with direct inhibitory effect on proliferation of SW-13 cells (P<0.05).
  
  
  CONCLUSIONS
  IGF can promote the growth of human adrenocortical carcinoma SW-13 cells via its receptor-I. IGF receptor-I antibody can inhibit the effect of the growth factor, suggesting a possible role of this receptor in the treatment of adrenocortical carcinoma.
authors.affiliation: Graduate School of Southern Medical University, Guangzhou 510515, China. shenxiwen27@hotmail.com
authors.forename: Wen
authors.initials: W
authors.lastname: Shen
authors.forename: Jiang
authors.initials: J
authors.lastname: Xian
authors.forename: Wei-Lie
authors.initials: WL
authors.lastname: Hu
authors.forename: Jun
authors.initials: J
authors.lastname: Liu
authors.forename: Jia
authors.initials: J
authors.lastname: Liu
mesh_terms: D018268:Adrenocortical Carcinoma / Q000473:pathology; D000906:Antibodies / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000494:pharmacology*; D017526:Receptor, IGF Type 1 / Q000276:immunology*
chemical_list: D000906:Antibodies; D007334:Insulin-Like Growth Factor I; D017526:Receptor, IGF Type 1