title: Effects of extracellular zinc ion on the rate of oxygen consumption of rat brain mitochondria.
abstract: The inhibitory effect of extracellular zinc ion on the rate of oxygen consumption of rat brain mitochondria pre-incubated in 1.0 mMol Ca(2+)EDTA were determined. There was a significant increase [P < 0.01] in the rate of oxygen consumption in the rat brain mitochondria pre-incubated in 1.0 mMol Ca(2+)EDTA in a succinate initiated reaction. The reverse was the case when the concentration of Ca(2+)EDTA was increased to 10 mMol. A 20 microMol zinc-aspartate was found to have no inhibitory effect on the rate of oxygen consumption of the brain mitochondria pre-incubated with 1.0 mMol Ca(2+)EDTA when compared with the control that lacked 1.0 mMol Ca(2+)EDTA, however there was a significant decrease [P < 0.01] in the rate of oxygen consumption of the rat brain mitochondria in the control experiment.
authors.affiliation: OCBS/Molecular Cell Biology, University of Maryland, Baltimore, Dental School, USA.
authors.forename: B I
authors.initials: BI
authors.lastname: Kukoyi
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D004492:Edetic Acid / Q000494:pharmacology; D008297:Male; D008928:Mitochondria / Q000187:drug effects* / Q000378:metabolism; D010101:Oxygen Consumption / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D019802:Succinic Acid / Q000378:metabolism; D015032:Zinc / Q000494:pharmacology*
chemical_list: D004492:Edetic Acid; D019802:Succinic Acid; D015032:Zinc