title: General asymmetric hydrogenation of alpha-branched aromatic ketones catalyzed by TolBINAP/DMAPEN-ruthenium(II) complex.
abstract: [reaction: see text] A catalyst system consisting of RuCl2[(S)-tolbinap][(R)-dmapen] and t-C4H9OK in 2-propanol effects asymmetric hydrogenation of arylglyoxal dialkylacetals to give the alpha-hydroxy acetals in up to 98% ee. Hydrogenation of racemic alpha-amidopropiophenones under dynamic kinetic resolution predominantly gives the syn alcohols in up to 99% ee and >98% de, while the reaction of racemic bezoin methyl ether gives the anti alcohols in excellent stereoselectivity.
authors.affiliation: Division of Chemical Process Engineering, Graduate School of Engineering, Hokkaido University, Sapporo 060-8628, Japan.
authors.forename: Noriyoshi
authors.initials: N
authors.lastname: Arai
authors.forename: Hirohito
authors.initials: H
authors.lastname: Ooka
authors.forename: Keita
authors.initials: K
authors.lastname: Azuma
authors.forename: Toshio
authors.initials: T
authors.lastname: Yabuuchi
authors.forename: Nobuhito
authors.initials: N
authors.lastname: Kurono
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Inoue
authors.forename: Takeshi
authors.initials: T
authors.lastname: Ohkuma