Synthesis of 2(1H)-pyrazinone phosphonates via an Arbuzov-type reaction.
A simple and catalyst-free method for the synthesis of phosphonated 2(1H)-pyrazinones is described starting from 3,5-dichloropyrazinones. The method also works for 3-bromo- and 3-iodopyrazinones. Classical heating conditions as well as microwave-enhanced reaction conditions were tested.
Alen
Jo
J
Molecular Design & Synthesis, Department of Chemistry, Katholieke Universiteit Leuven, Celestijnenlaan 200F, B-3001 Leuven, Belgium.
Dobrzańska
Liliana
L
De Borggraeve
Wim M
WM
Compernolle
Frans
F