[Study of mouse mammary tumor virus-like gene sequences expressing in breast tumors of Chinese women].
OBJECTIVE
To analyse the expression of mouse mammary tumor virus-like (MMTV-like) gene sequencesin breast cancer of Chinese women.


METHODS
Using nested PCR that amplify MMTV-like gene sequences, we tested the breast cancer tissues from 131 Chinese patients. The result was analyzed and compared with postoperative pathology and prevalence that had been reported from different populations.


RESULTS
MMTV-like gene sequences were amplified in 22 of 131 (16.8%) breast cancer biopsy tissues from Chinese patients, which had no relation to pathology, but had the significant difference from other populations.


CONCLUSIONS
MMTV-like gene sequences can be found in breast cancer tissue from Chinese women with breast cancer. This supports the contention that these sequences may represent a virus associated with human breast carcinogenesis. The differences in prevalence of MMTV-like gene sequences and breast cancer rates among populations may be related to geographic distribution.
Luo
Ting
T
Department of General Surgery, West China Hospital, Sichuan University, Chengdu 610041, China.
Wu
Xiao-Ting
XT
Zhang
Ming-Ming
MM
Qian
Kun
K
D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics*; D001706:Biopsy; D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008324:Mammary Tumor Virus, Mouse / Q000235:genetics*; D008875:Middle Aged; D016133:Polymerase Chain Reaction