Pediatric primary CNS lymphoma: longterm survival after treatment with radiation monotherapy.
Primary central nervous system lymphoma (PCNSL) in childhood is very rare. We report a 5-year-old boy who presented with headache and nausea. Magnetic resonance imaging (MRI) showed a faintly enhanced lesion in the left cerebellar hemisphere. MRI-guided biopsy was returned with a histopathological diagnosis of lymphoma. Cranial radiotherapy alone with whole-brain irradiation (30 Gy) followed by a 20-Gy booster to the tumor bed was successful and the patient is alive, well, and in persistent complete remission 14 years post-treatment. This is the only pediatric PCNSL encountered at our institution between 1989 and 2004.
Makino
K
K
Department of Neurosurgery, Kumamoto University Graduate School, Kumamoto, Japan. kmakino@fc.kuh.kumamoto-u.ac.jp
Nakamura
H
H
Yano
S
S
Kuratsu
J-I
JI
D001706:Biopsy; D002528:Cerebellar Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D002531:Cerebellum / Q000473:pathology; D002675:Child, Preschool; D016371:Cranial Irradiation; D005500:Follow-Up Studies; D006801:Humans; D008223:Lymphoma / Q000175:diagnosis / Q000473:pathology / Q000532:radiotherapy*; D008279:Magnetic Resonance Imaging; D008297:Male