title: Synthesis and evaluation of (S)-2-ethoxy-3-phenylpropanoic acid derivatives as insulin-sensitizing agents.
abstract: A series of (S)-2-ethoxy-3-phenylpropanoic acid derivatives were synthesized and their insulin-sensitizing activities were evaluated in 3T3-L1 cells. Compounds 1b and 1d exhibited more potent insulin-sensitizing activity than rosiglitazone.
authors.affiliation: Department of Pharmaceuticals, HuaiHua Medical College, Huaihua 418000, PR China. caixh1111@163.com
authors.forename: Xiaohua
authors.initials: X
authors.lastname: Cai
authors.forename: Bing
authors.initials: B
authors.lastname: Xie
authors.forename: Hui
authors.initials: H
authors.lastname: Guo
mesh_terms: D041721:3T3-L1 Cells; D000818:Animals; D007004:Hypoglycemic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D007328:Insulin / Q000494:pharmacology*; D051379:Mice; D010666:Phenylpropionates / Q000138:chemical synthesis* / Q000494:pharmacology*; D000077154:Rosiglitazone; D045162:Thiazolidinediones / Q000494:pharmacology
chemical_list: D007004:Hypoglycemic Agents; D007328:Insulin; D010666:Phenylpropionates; D045162:Thiazolidinediones; D000077154:Rosiglitazone