Does ondansetron or granisetron prevent subarachnoid morphine-induced pruritus after cesarean delivery?
BACKGROUND
We compared the efficacy of granisetron and ondansetron for the prevention of subarachnoid morphine-induced pruritus after cesarean delivery.


METHODS
The incidence of pruritus was assessed in parturients who were randomly allocated into Group G (granisetron 3 mg IV, n = 45), Group O (ondansetron 8 mg IV, n = 42), and Group S (saline IV, n = 42).


RESULTS
The incidence of pruritus was not significantly different among the 3 groups (86.6% in Group S, 83.3% in Group O, and 88% in the Group G).


CONCLUSIONS
Neither prophylactic ondansetron nor granisetron reduced the incidence of subarachnoid morphine-induced pruritus when compared with the saline group.
Siddik-Sayyid
Sahar M
SM
Department of Anesthesiology, American University of Beirut Medical center, Beirut, Lebanon. ss01@aub.edu.lb
Aouad
Marie T
MT
Taha
Samar K
SK
Azar
Mireille S
MS
Hakki
Mona A
MA
Kaddoum
Romeo N
RN
Nasr
Viviane G
VG
Yazbek
Vanda G
VG
Baraka
Anis S
AS
D000328:Adult; D000982:Antipruritics / Q000494:pharmacology / Q000627:therapeutic use*; D002585:Cesarean Section; D005260:Female; D017829:Granisetron / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D007278:Injections, Spinal; D009020:Morphine / Q000009:adverse effects* / Q000494:pharmacology; D017294:Ondansetron / Q000494:pharmacology / Q000627:therapeutic use*; D011247:Pregnancy; D011537:Pruritus / Q000139:chemically induced* / Q000453:epidemiology / Q000517:prevention & control*; D013346:Subarachnoid Space / Q000187:drug effects* / Q000502:physiology
D000982:Antipruritics; D017829:Granisetron; D009020:Morphine; D017294:Ondansetron