Binding sites on laminin receptors as components for antibiotics.
Bacteria use the receptor-adhesion-like interaction between laminin and the laminin receptor in the process of infection. We determined that bacteria do not interact with the receptor-binding site on laminin which could be expected for the bacterial laminin receptor. Rather, binding occurs via the laminin-binding site on the 67-kDa laminin receptor, which has a function similar to the one the bacterial laminin receptor possesses. This finding has implications for the effective use of antimicrobial peptides.
Kobayashi
Nahoko
N
Nagoya R&D Institute, Toagosei Co., Ltd., Nagoya, 455-0027, Japan.
Yoshida
Tetsuhiko
T
D000595:Amino Acid Sequence; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000378:metabolism*; D001665:Binding Sites; D007797:Laminin / Q000737:chemistry / Q000378:metabolism; D008969:Molecular Sequence Data; D011550:Pseudomonas aeruginosa; D017474:Receptors, Laminin / Q000737:chemistry* / Q000378:metabolism*; D011994:Recombinant Proteins; D013211:Staphylococcus aureus
D000900:Anti-Bacterial Agents; D007797:Laminin; D017474:Receptors, Laminin; D011994:Recombinant Proteins