title: Functional, structural, and immunological compartmentalisation of malaria invasive proteins.
abstract: Conserved Plasmodium falciparum merozoite high activity binding peptides (HABPs) involved in red blood cell (RBC) invasion which are present in merozoite surface proteins (MSPs) involved in attachment, rolling over RBC, those derived from soluble proteins loosely bound to the membrane, and those present in microneme and rhoptry organelles have an alpha-helical structure and bind with high affinity to HLA-DR52 molecules. On the contrary, conserved HABPs belonging to molecules anchored to the membrane by a GPI tail, or a transmembranal region, or those molecules presenting PEXEL motifs have a strand, turn or unordered configuration and bind with high affinity to HLA-DR53 molecules. Such functional, cellular, structural, and immunological compartmentalisation has tremendous implications in subunit-based, multi-epitope, synthetic, anti-malarial vaccine development.
authors.affiliation: Fundación Instituto de Inmunología de Colombia (FIDIC), Carrera 50#26-00, Bogota, Colombia.
authors.forename: Claudia
authors.initials: C
authors.lastname: Reyes
authors.forename: Manuel Elkin
authors.initials: ME
authors.lastname: Patarroyo
authors.forename: Luis Eduardo
authors.initials: LE
authors.lastname: Vargas
authors.forename: Luis Eduardo
authors.initials: LE
authors.lastname: Rodríguez
authors.forename: Manuel Alfonso
authors.initials: MA
authors.lastname: Patarroyo
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000953:Antigens, Protozoan / Q000737:chemistry* / Q000502:physiology*; D004912:Erythrocytes / Q000378:metabolism / Q000469:parasitology; D006684:HLA-DR Antigens / Q000378:metabolism; D006801:Humans; D008288:Malaria / Q000276:immunology / Q000378:metabolism* / Q000469:parasitology; D008969:Molecular Sequence Data; D010963:Plasmodium falciparum / Q000737:chemistry / Q000276:immunology / Q000378:metabolism / Q000472:pathogenicity*; D011485:Protein Binding / Q000276:immunology; D015800:Protozoan Proteins / Q000737:chemistry* / Q000378:metabolism / Q000502:physiology*
chemical_list: D000953:Antigens, Protozoan; D006684:HLA-DR Antigens; D015800:Protozoan Proteins