[Influence of probiotic subalin on efficiency of antitumor vaccine].
Preparation subalin created on the basis of a recombinant strain of B. subtilis 2335/105 containing the gene of synthesis of human a-2-interferon has been tested in the experiment for its ability of increasing the efficiency of antitumor vaccine prepared from syngenic tumor cells and cytotoxic lectin--the metabolism product of the strain of B. subtilis B-7025. On the models of Lewis lung carcinoma of C57B1 mice and sarcoma-37 of Balb/c mice it was shown that the complex use of the antitumor vaccine and subalin makes for the more efficient tumor growth suppression and survival of treated animals as compared with the separate use of autovaccine or subalin. The prospects and expediency of the complex use of vaccine and subalin at malignant tumors immunotherapy were established.
Potebnia
H P
HP
Safronova
L A
LA
Cheremshenko
N L
NL
Lisovenko
H S
HS
Sorokulova
I B
IB
Prykhod'ko
V O
VO
Trokhymenko
N V
NV
Tanasiienko
O A
OA
Bombin
A V
AV
D000818:Animals; D001412:Bacillus subtilis / Q000235:genetics / Q000378:metabolism; D001685:Biological Factors / Q000008:administration & dosage / Q000302:isolation & purification / Q000627:therapeutic use*; D019496:Cancer Vaccines / Q000008:administration & dosage / Q000627:therapeutic use*; D018827:Carcinoma, Lewis Lung / Q000188:drug therapy*; D006801:Humans; D016233:Immunotherapy, Active / Q000379:methods*; D007370:Interferon Type I / Q000235:genetics; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D019936:Probiotics / Q000008:administration & dosage / Q000302:isolation & purification / Q000627:therapeutic use*; D011994:Recombinant Proteins; D012511:Sarcoma 37 / Q000188:drug therapy*; D016896:Treatment Outcome
D001685:Biological Factors; D019496:Cancer Vaccines; D007370:Interferon Type I; D011994:Recombinant Proteins; C112120:subalin