title: Did the histologic diversity of the primary tumor affect the patient's outcome in gastric cancer?
abstract: The objective of this study was to evaluate the clinical significance of the histologic diversity of primary lesions in the gastric cancer patient. This study included 165 patients with node-negative gastric cancer who underwent curative gastrectomy. Grade of histologic diversity in primary lesion was classified as 1, 2, 3, and 4 histologic types by the number of the composing histologic types, regardless of the predominant histologic type. The relationships between the number of histologic types and the clinicopathological parameters were studied. There was no progressive increase in the number of kinds of histologic types with increasing depth of invasion of the tumor. Analysis of survival rates by number of histologic types showed that the increasing number of composing histologic types was not associated with a poorer prognosis. We were not able to predict the prognosis by studying the number of histologic types composing the primary lesions in node-negative gastric cancer.
authors.affiliation: Department of Surgery, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa 259-1193, Japan. nakaken@is.icc.u-tokai.ac.jp
authors.forename: Kenji
authors.initials: K
authors.lastname: Nakamura
authors.forename: Kyoji
authors.initials: K
authors.lastname: Ogoshi
authors.forename: Hiroyasu
authors.initials: H
authors.lastname: Makuuchi
mesh_terms: D005743:Gastrectomy; D006801:Humans; D008875:Middle Aged; D011379:Prognosis; D013274:Stomach Neoplasms / Q000145:classification / Q000401:mortality / Q000473:pathology* / Q000601:surgery*; D015996:Survival Rate