Dermatitis herpetiformis: no evidence of bone disease despite evidence of enteropathy.
The majority of patients with dermatitis herpetiformis (DH) have small intestinal enteropathy that may result in bone loss. The objective of this study was to evaluate bone mineral density (BMD) in DH and to examine whether dietary treatment or degree of the small intestinal lesion correlate with BMD. Twenty-five patients with DH (18 men) were investigated. Detailed dietary assessment and duodenal biopsies were performed on all patients before entry into the study. BMD at lumbar spine and femur was determined by DXA scan. Bone biomarkers, vitamin D, and parathyroid status were assessed. Twenty patients had enteropathy. None of the patients had hypovitaminosis D or secondary hyperparathyroidism. Resorption and formation markers were within normal limits. BMD Z-scores were not significantly different from expected (-0.38; CI, -0.84 to 0.07) and femur (0.46; CI, -0.06 to 0.97). There was no relationship between BMD Z-scores and the severity of the degree of enteropathy. We conclude that enteropathy of differing severity is present in 80% of patients with DH, but this is not associated with bone disease.
Abuzakouk
M
M
Department of Immunology, CPL, St. James's Hospital, Dublin, 8 Ireland. abuzakm@tcd.ie
Barnes
L
L
O'Gorman
N
N
O'Grady
A
A
Mohamed
B
B
McKenna
M J
MJ
Freaney
R
R
Feighery
C
C
D000328:Adult; D015519:Bone Density; D002446:Celiac Disease / Q000453:epidemiology / Q000473:pathology / Q000503:physiopathology*; D015897:Comorbidity; D003720:Densitometry; D003874:Dermatitis Herpetiformis / Q000453:epidemiology / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology*; D004386:Duodenum / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged