title: A computational study on the influence of catheter-delivered intravascular probes on blood flow in a coronary artery model.
abstract: Catheter-delivered intravascular probes are widely used in clinical practice to measure coronary arterial velocity and pressure, but the artefactual effect of the probe on the variables being measured is not well characterised. A coronary artery was simulated with a 180 degrees curved tube 3mm in diameter and the effect of catheters of different diameters was modelled numerically under pulsatile flow conditions. The presence of a catheter increased pressure by 1.3-4.3 mmHg depending on its diameter, and reduced velocity-pressure phase-lag. For an ultrasound sample volume 5mm downstream from the probe tip, the underestimation in velocity measurement attributed to catheter blockage is approximately 15-21% for an average inlet velocity of 0.1m/s. The velocity measurement error is lower at higher mean flow velocity. Accuracy of clinical velocity measurements could be improved by moving the sample volume farther downstream from the probe tip, because the centrifugal pressure gradient intrinsic to the curvature promotes re-development of flow.
authors.affiliation: Department of Chemical Engineering, Imperial College London, UK. r.torii@imperial.ac.uk
authors.forename: Ryo
authors.initials: R
authors.lastname: Torii
authors.forename: Nigel B
authors.initials: NB
authors.lastname: Wood
authors.forename: Alun D
authors.initials: AD
authors.lastname: Hughes
authors.forename: Simon A
authors.initials: SA
authors.lastname: Thom
authors.forename: Jazmin
authors.initials: J
authors.lastname: Aguado-Sierra
authors.forename: Justin E
authors.initials: JE
authors.lastname: Davies
authors.forename: Darrel P
authors.initials: DP
authors.lastname: Francis
authors.forename: Kim H
authors.initials: KH
authors.lastname: Parker
authors.forename: X Yun
authors.initials: XY
authors.lastname: Xu
mesh_terms: D001783:Blood Flow Velocity; D001794:Blood Pressure; D002404:Catheterization; D003331:Coronary Vessels / Q000502:physiology*; D006801:Humans; D008955:Models, Cardiovascular; D011673:Pulsatile Flow; D015203:Reproducibility of Results; D012107:Research Design