title: Guaiane sesquiterpene lactones from Salvia nubicola (Lamiaceae).
abstract: A new sesquiterpene lactone, nubiol (1), belonging to the guaiane class, along with a dimer, bisnubidiol (2), has been isolated from Salvia nubicola collected from Quetta, Pakistan. The structures of both metabolites were elucidated with the aid of spectroscopic techniques including 2D-NMR. Additionally, the structure of nubiol (1) was finally confirmed via the single crystal X-ray diffraction. Nubiol (1) was found moderately active against Pseudomonas aeruginosa.
authors.affiliation: H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan. shaiq303@hotmail.com
authors.forename: Muhammad S
authors.initials: MS
authors.lastname: Ali
authors.forename: Syed A
authors.initials: SA
authors.lastname: Ibrahim
authors.forename: Shakeel
authors.initials: S
authors.lastname: Ahmed
authors.forename: Emil
authors.initials: E
authors.lastname: Lobkovsky
mesh_terms: D018360:Crystallography, X-Ray; D003508:Cycloheptanes / Q000737:chemistry*; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification*; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D015394:Molecular Structure; D027544:Salvia / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry*; D045789:Sesquiterpenes, Guaiane / Q000737:chemistry*
chemical_list: D003508:Cycloheptanes; D007783:Lactones; D012717:Sesquiterpenes; D045789:Sesquiterpenes, Guaiane; C421026:guaiane