title: Seizure freedom off antiepileptic drugs after temporal lobe epilepsy surgery.
abstract: Data are limited on seizure recurrence after antiepileptic drug (AED) discontinuation in operated seizure-free patients. We reviewed seizure outcome in patients who came off AEDs after being seizure-free for 2 years following temporal lobe surgery in our center. Thirty-nine (68%) of 57 patients who discontinued AED therapy remained seizure-free. They had a younger age at surgery than the group with seizure recurrence (p=0.01). Earlier surgery may be a favorable predictor for seizure freedom after AED discontinuation.
authors.affiliation: Department of Neurology, Vanderbilt University Medical Center, 2311 Pierce Avenue, Nashville, TN 37232, USA.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Al-Kaylani
authors.forename: Peter
authors.initials: P
authors.lastname: Konrad
authors.forename: Barry
authors.initials: B
authors.lastname: Lazenby
authors.forename: Bennett
authors.initials: B
authors.lastname: Blumenkopf
authors.forename: Bassel
authors.initials: B
authors.lastname: Abou-Khalil
mesh_terms: D000328:Adult; D000367:Age Factors; D038481:Anterior Temporal Lobectomy; D000927:Anticonvulsants / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D004833:Epilepsy, Temporal Lobe / Q000188:drug therapy / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012008:Recurrence; D012074:Remission Induction; D016896:Treatment Outcome
chemical_list: D000927:Anticonvulsants