title: Adjuvant chemotherapy in a pregnant woman with endodermal sinus tumor of the ovary.
abstract: BACKGROUND
  The administration of chemotherapeutic drugs during pregnancy is rare. We describe a case of malignant ovarian tumor complicating pregnancy.
  
  
  METHODS
  After laparotomy at 18 weeks of gestation, the patient received three courses of cisplatin, vinblastine, and bleomycin. Elective cesarean delivery was performed at 31 weeks of gestation. A normal infant was delivered, and no evidence of tumor recurrence was observed. Metastasis to the liver was detected in the fifth month after delivery. However, this was treated successfully with three courses of cisplatin, etoposide, and bleomycin. There was no evidence of recurrence observed at 65 months after the initial treatment.
  
  
  CONCLUSIONS
  Although the risk of chemotherapy to the fetus cannot be assessed based on a single case, this experience is encouraging.
authors.affiliation: Department of Obstetrics and Gynecology, The Jikei University School of Medicine, Tokyo, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Motegi
authors.forename: Satoshi
authors.initials: S
authors.lastname: Takakura
authors.forename: Hirokuni
authors.initials: H
authors.lastname: Takano
authors.forename: Tadao
authors.initials: T
authors.lastname: Tanaka
authors.forename: Kazunori
authors.initials: K
authors.lastname: Ochiai
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001761:Bleomycin / Q000008:administration & dosage; D002585:Cesarean Section; D017024:Chemotherapy, Adjuvant; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D003937:Diagnosis, Differential; D018240:Endodermal Sinus Tumor / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D010051:Ovarian Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology / Q000601:surgery; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology / Q000601:surgery; D011263:Pregnancy Trimester, Third; D011295:Prenatal Care; D011296:Prenatal Diagnosis; D014747:Vinblastine / Q000008:administration & dosage
chemical_list: D001761:Bleomycin; D014747:Vinblastine; D002945:Cisplatin