title: Revised structures of gambiriins A1, A2, B1, and B2, chalcane-flavan dimers from gambir (Uncaria gambir extract).
abstract: Gambir, the aqueous extract from Uncaria gambir (Rubiaceae), has been used as an astringent medicine in Asian countries. Investigation of the constituents in the extract led to the isolation of four chalcane-flavan dimers, gambiriin A1 (6), A2 (7), B1 (8), and B2 (9), in addition to (+)-catechin (1), (+)-epicatechin (2), and dimeric proanthocyanidins, procyanidin B1 (3), procyanidin B3 (4), and gambiriin C (5). The spectroscopic and chemical data obtained in the present study indicated that their previously proposed structures 6a, 7a, 8a, and 9a should be revised to 6, 7, 8, and 9, respectively.
authors.affiliation: Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
authors.forename: Shoko
authors.initials: S
authors.lastname: Taniguchi
authors.forename: Kayo
authors.initials: K
authors.lastname: Kuroda
authors.forename: Kou-ichi
authors.initials: K
authors.lastname: Doi
authors.forename: Masahiro
authors.initials: M
authors.lastname: Tanabe
authors.forename: Takashi
authors.initials: T
authors.lastname: Shibata
authors.forename: Takashi
authors.initials: T
authors.lastname: Yoshida
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Hatano
mesh_terms: D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification; D000975:Antioxidants / Q000737:chemistry* / Q000302:isolation & purification; D044946:Biflavonoids / Q000737:chemistry / Q000302:isolation & purification; D002392:Catechin / Q000737:chemistry / Q000302:isolation & purification; D002599:Chalcone / Q000031:analogs & derivatives* / Q000302:isolation & purification; D019281:Dimerization; D005419:Flavonoids / Q000737:chemistry* / Q000302:isolation & purification; D007211:Indoles / Q000737:chemistry* / Q000302:isolation & purification; D010936:Plant Extracts / Q000737:chemistry*; D010946:Plants, Medicinal; D044945:Proanthocyanidins / Q000737:chemistry / Q000302:isolation & purification; D019666:Rubiaceae / Q000737:chemistry*; D013057:Spectrum Analysis
chemical_list: D000470:Alkaloids; D000975:Antioxidants; D044946:Biflavonoids; D005419:Flavonoids; D007211:Indoles; D010936:Plant Extracts; D044945:Proanthocyanidins; C479579:procyanidin B1; C077749:gambirine; C479581:procyanidin B3; D002599:Chalcone; D002392:Catechin