Antinociceptive and anti-inflammatory properties of Corchorus capsularis leaves chloroform extract in experimental animal models.
The antinociceptive and anti-inflammatory properties of Corchorus capsularis leaves chloroform extract were investigated in experimental animal models. The antinociceptive activity was measured using the writhing, hot plate and formalin tests, while the anti-inflammatory activity was measured using the carrageenan-induced paw edema test. The extract, obtained after 72 h soaking of the air-dried leaves in chloroform followed by in vacuo evaporation to dryness, was weighed and prepared by serial dilution in DMSO in the doses of 20, 100 and 200 mg/kg. The extract was administered (s.c.) 30 min prior to subjection to the respective assays. The extract was found to exhibit significant (p < 0.05) antinociceptive and anti-inflammatory activities. As a conclusion, the present study confirmed the traditional claims of using C. capsularis to treat various ailments related to inflammation and pain.
Zakaria
Zainul Amiruddin
ZA
Faculty of Biotechnology and Life Sciences, Universiti Industri Selangor, Selangor, Malaysia. shaza8174@yahoo.com
Sulaiman
Mohd Roslan
MR
Gopalan
Hanan Kumar
HK
Abdul Ghani
Zuleen Delina Fasya
ZD
Raden Mohd Nor
Raden Nur Suraya
RN
Mat Jais
Abdul Manan
AM
Abdullah
Fatimah Corazon
FC
D000700:Analgesics / Q000302:isolation & purification* / Q000627:therapeutic use*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000302:isolation & purification* / Q000627:therapeutic use*; D002725:Chloroform; D032381:Corchorus / Q000737:chemistry*; D004487:Edema / Q000517:prevention & control*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D023421:Models, Animal; D010146:Pain / Q000517:prevention & control*; D008517:Phytotherapy; D010936:Plant Extracts / Q000302:isolation & purification* / Q000627:therapeutic use*; D018515:Plant Leaves / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley
D000700:Analgesics; D000893:Anti-Inflammatory Agents; D010936:Plant Extracts; D002725:Chloroform