Antifungal acylcyclopentenediones from fruiting bodies of Hygrophorus chrysodon.
Chrysotriones A (1) and B (2), two new 2-acylcyclopentene-1,3-dione derivatives, were isolated from the fruiting bodies of the Basidiomycete Hygrophorus chrysodon, and their structures were established by spectroscopic data and synthesis of compound 2. They represent the first examples of 2-acylcyclopentene-1,3-diones found in mushrooms and suggest an unprecedented biosynthetic pathway, starting from fatty acid derivatives. Initial tests indicated interesting antifungal activity of chrysotriones against Fusarium verticillioides, one of the common worldwide pathogens of cultivated plants.
Gilardoni
Gianluca
G
Dipartimento di Chimica Organica, Università di Pavia, Via Taramelli 10, 27100 Pavia, Italy.
Clericuzio
Marco
M
Tosi
Solveig
S
Zanoni
Giuseppe
G
Vidari
Giovanni
G
D000363:Agaricales / Q000737:chemistry*; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D003517:Cyclopentanes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D048690:Fruiting Bodies, Fungal / Q000737:chemistry; D005670:Fusarium / Q000187:drug effects*; D007558:Italy; D015394:Molecular Structure
D000935:Antifungal Agents; D003517:Cyclopentanes