title: Preoperative chemoradiation and flap reconstruction provide high local control and low wound complication rates for patients undergoing limb salvage surgery for upper extremity tumors.
abstract: OBJECTIVE
  Neoadjuvant protocols in the management of upper extremity sarcoma have improved local control rates but have been associated with high complication rates. We present a refinement of the Eilber protocol using judicious preoperative chemoradiation, limb salvage surgery, and flap coverage to achieve high local control rates with acceptable wound healing complications.
  
  
  METHODS
  Patients presenting with upper extremity neoplasms from 1986 to 2002 were treated with a modified Eilber protocol, consisting of 3 days of adriamycin (30 mg/day) and sequential radiotherapy (300 cGy/day for 10 days). Limb salvage surgery with flap coverage where needed was performed 4-8 weeks later. Patients were followed prospectively for recurrence.
  
  
  RESULTS
  Fifty-three consecutive patients with upper extremity tumors were treated and followed for a mean of 6.1 years. This cohort included 44 sarcomas and nine non-metastasizing, locally aggressive tumors. There were two local recurrences (3.8%). Limb salvage was achieved in all patients. Flaps were required in 43.4% of patients. Major complications occurred in 11%, were all flap related (partial flap loss, venous congestion), and went on to heal promptly with treatment.
  
  
  CONCLUSIONS
  This modified Eilber protocol achieved 96% local control for upper extremity tumors with a wound complication rate of 11%. The liberal use of flaps of resulted in healed, stable wounds in all patients.
authors.affiliation: Division of Plastic Surgery, University of Western Ontario, Ontario, Canada. ctemple4@uwo.ca
authors.forename: C L F
authors.initials: CL
authors.lastname: Temple
authors.forename: D C
authors.initials: DC
authors.lastname: Ross
authors.forename: E
authors.initials: E
authors.lastname: Magi
authors.forename: L M
authors.initials: LM
authors.lastname: DiFrancesco
authors.forename: E
authors.initials: E
authors.lastname: Kurien
authors.forename: W J
authors.initials: WJ
authors.lastname: Temple
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage; D003131:Combined Modality Therapy; D004317:Doxorubicin / Q000008:administration & dosage; D004334:Drug Administration Schedule; D005500:Follow-Up Studies; D006801:Humans; D023821:Limb Salvage; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D009364:Neoplasm Recurrence, Local / Q000401:mortality; D011300:Preoperative Care; D011446:Prospective Studies; D011879:Radiotherapy Dosage; D019651:Plastic Surgery Procedures; D012509:Sarcoma / Q000188:drug therapy / Q000401:mortality / Q000532:radiotherapy / Q000601:surgery*; D012983:Soft Tissue Neoplasms / Q000188:drug therapy / Q000401:mortality / Q000532:radiotherapy / Q000601:surgery*; D013524:Surgical Flaps; D034941:Upper Extremity
chemical_list: D000903:Antibiotics, Antineoplastic; D004317:Doxorubicin