title: Structural basis for cyclophellitol inhibition of a beta-glucosidase.
abstract: The structural basis for beta-glucosidase inhibition by cyclophellitol is demonstrated using X-ray crystallography, enzyme kinetics and mass spectrometry.
authors.affiliation: York Structural Biology Laboratory, Department of Chemistry, University of York, Heslington, York, UK YO10 5YW.
authors.forename: Tracey M
authors.initials: TM
authors.lastname: Gloster
authors.forename: Robert
authors.initials: R
authors.lastname: Madsen
authors.forename: Gideon J
authors.initials: GJ
authors.lastname: Davies
mesh_terms: D018360:Crystallography, X-Ray; D003511:Cyclohexanols / Q000737:chemistry / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D004795:Enzyme Stability; D006868:Hydrolysis; D007700:Kinetics; D013058:Mass Spectrometry; D001617:beta-Glucosidase / Q000037:antagonists & inhibitors* / Q000378:metabolism
chemical_list: D003511:Cyclohexanols; D004791:Enzyme Inhibitors; C063285:cyclophellitol; D001617:beta-Glucosidase