title: Stable pattern of HIV-1 subtype C Gag-specific T-cell responses coincides with slow rate of CD4 T-cell decline in HIV-infected Ethiopians.
abstract: We studied HIV-1 clade C Gag-specific T-cell responses in five HIV-infected Ethiopians with a relatively slow (< 15 cells/microl per year) and five with a fast (> 45 cells/microl per year) CD4 T-cell decline longitudinally. Six study subjects had T-cell responses directed to one or more HIV-1 Gag peptides. The persistence of strong and broad anti-Gag cytotoxic T-lymphocyte responses was associated with a slow rate of CD4 T-cell decline and with human leukocyte antigen alleles from the B27 supertype.
authors.affiliation: Ethio-Netherlands AIDS Research Project, Ethiopian Health and Nutrition Research Institute, PO Box 1242, Addis Ababa, Ethiopia.
authors.forename: Aster
authors.initials: A
authors.lastname: Tsegaye
authors.forename: Leonie
authors.initials: L
authors.lastname: Ran
authors.forename: Dawit
authors.initials: D
authors.lastname: Wolday
authors.forename: Beyene
authors.initials: B
authors.lastname: Petros
authors.forename: Nening M
authors.initials: NM
authors.lastname: Nanlohy
authors.forename: Hailu
authors.initials: H
authors.lastname: Meles
authors.forename: Mulu
authors.initials: M
authors.lastname: Girma
authors.forename: Ermias
authors.initials: E
authors.lastname: Hailu
authors.forename: José
authors.initials: J
authors.lastname: Borghans
authors.forename: Frank
authors.initials: F
authors.lastname: Miedema
authors.forename: Debbie
authors.initials: D
authors.lastname: van Baarle
mesh_terms: D018791:CD4 Lymphocyte Count; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D015683:Gene Products, gag / Q000276:immunology*; D015658:HIV Infections / Q000276:immunology* / Q000821:virology; D015497:HIV-1 / Q000145:classification / Q000276:immunology*; D006801:Humans; D008137:Longitudinal Studies; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D019562:Viral Load
chemical_list: D015683:Gene Products, gag