Simple and efficient heterogeneous copper catalysts for enantioselective C-H carbene insertion.
Immobilized box-Cu complexes are able to efficiently catalyze the insertion of a carbene, from methyl phenyldiazoacetate, into C-H bonds of THF, with high enantioselectivity (up to 88% ee). The immobilization not only allows recovery and reuse of the enantioselective catalyst but also provides an improvement in the selectivities from the values obtained in solution, probably due to a confinement effect of the bidimensional support. [reaction: see text].
Fraile
José M
JM
Departamento de Química OrgAnica, Instituto de Ciencia de Materiales de Aragón and Instituto Universitario de CatAlisis Homogénea, Universidad de Zaragoza-C.S.I.C., E-50009 Zaragoza, Spain. jmfraile@unizar.es
García
José I
JI
Mayoral
José A
JA
Roldán
Marta
M