title: Diffusion tensor imaging: Application to the study of the developing brain.
abstract: OBJECTIVE
  To provide an overview of diffusion tensor imaging (DTI) and its application to the study of white matter in the developing brain in both healthy and clinical samples.
  
  
  METHODS
  The development of DTI and its application to brain imaging of white matter tracts is discussed. Forty-eight studies using DTI to examine diffusion properties of the developing brain are reviewed in the context of the structural magnetic resonance imaging literature. Reports of how brain diffusion properties are affected in pediatric clinical samples and how they relate to cognitive and behavioral phenotypes are reviewed.
  
  
  RESULTS
  DTI has been used successfully to describe white matter development in pediatric samples. Changes in white matter diffusion properties are consistent across studies, with anisotropy increasing and overall diffusion decreasing with age. Diffusion measures in relevant white matter regions correlate with behavioral measures in healthy children and in clinical pediatric samples.
  
  
  CONCLUSIONS
  DTI is an important tool for providing a more detailed picture of developing white matter than can be obtained with conventional magnetic resonance imaging alone.
authors.affiliation: Neurodevelopmental Disorders Research Center, Campus Box #3366, University of North Carolina, Chapel Hill, NC 27599-3366, USA.
authors.forename: Carissa J
authors.initials: CJ
authors.lastname: Cascio
authors.forename: Guido
authors.initials: G
authors.lastname: Gerig
authors.forename: Joseph
authors.initials: J
authors.lastname: Piven
mesh_terms: D000293:Adolescent; D000367:Age Factors; D001921:Brain / Q000473:pathology*; D002648:Child; D002675:Child, Preschool; D002658:Developmental Disabilities / Q000175:diagnosis* / Q000209:etiology; D038524:Diffusion Magnetic Resonance Imaging; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D009413:Nerve Fibers, Myelinated / Q000473:pathology*; D012016:Reference Values