title: High-order aberrations and preoperative associated factors.
abstract: OBJECTIVE
  The purpose of this study was to determine which preoperative factors are associated with the presence of high-order aberrations.
  
  
  METHODS
  A total of 93 eyes of 52 subjects were evaluated preoperatively between 1 January and 31 March 2003, using a Hartmann-Shack-based aberrometer. Age, gender, cycloplegic refraction, pupil size, keratometry readings, anterior chamber depth, white-to-white tests, intraocular pressure and basic secretion tests were evaluated.
  
  
  RESULTS
  Factors associated with high-order aberrations included age > or = 40 years (mean 4.39 +/- 2.95 microm; p = 0.03, Mann-Whitney test), higher keratometry values (44.96 +/- 1.57 D) (r = 0.447, p < 0.001, Spearman's correlation coefficient), higher degrees of myopia (> or = - 6.1 D) (p < 0.001, Kruskall-Wallis test) and increasing pupil size (p < 0.001, anova). Other factors including anterior chamber depth, white-to-white results, intraocular pressure and basic secretion test results did not correlate with the presence of high-order aberrations preoperatively.
  
  
  CONCLUSIONS
  Ocular wavefront aberrations varied greatly from subject to subject. Treatment should be customized for each laser based on patient characteristics in order to ensure the optimal treatment profile for the aberration.
authors.affiliation: Magill Research Center for Vision Correction, Storm Eye Institute, Medical University of South Carolina, Charleston, SC 29425, USA. decastro@musc.edu
authors.forename: Luis E Fernández
authors.initials: LE
authors.lastname: de Castro
authors.forename: Helga P
authors.initials: HP
authors.lastname: Sandoval
authors.forename: Luanna R
authors.initials: LR
authors.lastname: Bartholomew
authors.forename: David T
authors.initials: DT
authors.lastname: Vroman
authors.forename: Kerry D
authors.initials: KD
authors.lastname: Solomon
mesh_terms: D000328:Adult; D000867:Anterior Chamber / Q000033:anatomy & histology; D005260:Female; D006801:Humans; D007429:Intraocular Pressure; D020731:Keratomileusis, Laser In Situ; D008297:Male; D011300:Preoperative Care; D011680:Pupil / Q000502:physiology; D012029:Refraction, Ocular; D012030:Refractive Errors / Q000209:etiology*; D054140:Refractive Surgical Procedures; D012307:Risk Factors