Cardiometabolic risk in impaired fasting glucose and impaired glucose tolerance: the Atherosclerosis Risk in Communities Study.
OBJECTIVE
We compared and contrasted cardiovascular disease (CVD) risk factors, subclinical manifestations of CVD, incident coronary heart disease (CHD), and all-cause mortality by categories of impaired glucose regulation in nondiabetic individuals.


METHODS
The study included 6,888 participants aged 52-75 years who had no history of diabetes or CVD. All-cause mortality and incident CHD were ascertained over a median of 6.3 years of follow-up.


RESULTS
Agreement between fasting and postchallenge glucose impairment was poor: 3,048 subjects (44%) had neither impaired fasting glucose (IFG) nor impaired glucose tolerance (IGT), 1,690 (25%) had isolated IFG, 1,000 (14%) had isolated IGT, and 1,149 (17%) had both IFG and IGT. After adjustment for age, sex, race, and center, subjects with isolated IFG were more likely to smoke, consume alcohol, and had higher mean BMI, waist circumference, LDL cholesterol, and fasting insulin and lower HDL cholesterol than those with isolated IGT, while subjects with isolated IGT had higher mean triglycerides, systolic blood pressure, and white cell counts. Measures of subclinical CVD and rates of all-cause mortality and incident CHD were similar in isolated IFG and isolated IGT.


CONCLUSIONS
Neither isolated IFG nor isolated IGT was associated with a more adverse CVD risk profile.
Pankow
James S
JS
Division of EpidemiologyCommunity Health, University of Minnesota, 1300 South Second Street, Suite 300, Minneapolis, MN 55454, USA. pankow@epi.umn.edu
Kwan
David K
DK
Duncan
Bruce B
BB
Schmidt
Maria I
MI
Couper
David J
DJ
Golden
Sherita
S
Ballantyne
Christie M
CM
D000368:Aged; D050197:Atherosclerosis / Q000453:epidemiology* / Q000401:mortality; D044383:Black People / Q000706:statistics & numerical data; D001786:Blood Glucose / Q000032:analysis*; D015992:Body Mass Index; D003327:Coronary Disease / Q000453:epidemiology / Q000401:mortality; D005215:Fasting; D005260:Female; D018149:Glucose Intolerance / Q000453:epidemiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D044469:Racial Groups; D012307:Risk Factors; D016019:Survival Analysis; D017539:Tunica Intima / Q000033:anatomy & histology / Q000473:pathology; D017540:Tunica Media / Q000033:anatomy & histology / Q000473:pathology; D014481:United States / Q000453:epidemiology; D044465:White People / Q000706:statistics & numerical data; D001741:Black or African American
D001786:Blood Glucose