title: Bilateral STN-DBS fails to improve non-motor fluctuations in a PD patient.
abstract: We report the case of a 60-year-old woman with Parkinson's disease and severe motor fluctuations. During OFF periods she presented both motor and non-motor symptoms, which ameliorated rapidly after each levodopa dose. After undergoing bilateral STN DBS, motor complications improved markedly while non-motor symptoms remained unchanged. Levodopa response is regarded as a good predictive factor for the prognosis of motor symptoms in PD patients undergoing surgery. However, our case suggests that its relation with the prognosis of non-motor symptoms might be different and remains to be addressed.
authors.affiliation: Parkinson's Disease and Movement Disorders Unit, Hospital de Clínicas "José de San Martín", Buenos Aires, Argentina.
authors.forename: Maria G
authors.initials: MG
authors.lastname: Cersosimo
authors.forename: Fabian
authors.initials: F
authors.lastname: Piedimonte
authors.forename: Gabriela B
authors.initials: GB
authors.lastname: Raina
authors.forename: Federico E
authors.initials: FE
authors.lastname: Micheli
mesh_terms: D046690:Deep Brain Stimulation / Q000379:methods*; D005260:Female; D006801:Humans; D008875:Middle Aged; D010300:Parkinson Disease / Q000628:therapy*; D020531:Subthalamic Nucleus / Q000502:physiology*; D017211:Treatment Failure