title: Preparation of hydrophilic polyhydroxyalkyl glutamine crosslinked films and its biodegradability.
abstract: Polybenzyl glutamate (PBLG) or polymethyl glutamate (PMLG) films have been aminolyzed with amino alcohol and crosslinked with aliphatic diamine at 60 degrees C for 48 h simultaneously which led to the formation of crosslinked films of polyhydroxyalkyl glutamine (PHAG). ATR-IR indicates that for the aminolysis of PBLG with 2-amino-1-ethanol or 3-amino-1-propanol, benzyl glutamate almost completely turned to hydroxyalkyl glutamine, however for the aminolysis of PMLG with 5-amino-1-pentanol, methyl glutamate partially turned to hydroxypentanyl glutamine. The water-swelling test shows that water-swelling ratio Q of PHAG films from amino alcohol with longer carbon chain was smaller, the PHAG films crosslinked by 1,2-diamino ethane have the higher water-swelling ratio Q, but the PHAG films crosslinked by 1,8-diamino octane have the lower water swelling ratio Q; and PHAG films with a greater amount of crosslinking agents have high crosslinking density or the low water swelling-ratio Q for same amino alcohol and diamine. It is obvious from in vitro enzymatic hydrolysis test that specimens with smaller swelling ratio Q displayed larger T(1/2), time for half weight digestion of PHAG film, that is, less biodegradability. Therefore, biodegradability of the crosslinked PHAG films can be controlled by changing amino alcohol and diamine.
authors.affiliation: Cardiovascular Laboratory, The First Affiliated Hospital, Sun Yet-Sen University, 58 Zhongshan Road, Guangzhou 510080, PR China. gzpshr@163.com
authors.forename: Shi-Rong
authors.initials: SR
authors.lastname: Pan
authors.forename: Qin-Mei
authors.initials: QM
authors.lastname: Wang
authors.forename: Wu
authors.initials: W
authors.lastname: Yi
mesh_terms: D000605:Amino Alcohols / Q000737:chemistry*; D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry*; D003432:Cross-Linking Reagents / Q000737:chemistry; D003959:Diamines / Q000737:chemistry*; D006868:Hydrolysis; D008422:Materials Testing; D010206:Papain / Q000737:chemistry; D011099:Polyglutamic Acid / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D013055:Spectrophotometry, Infrared
chemical_list: D000605:Amino Alcohols; D001672:Biocompatible Materials; D003432:Cross-Linking Reagents; D003959:Diamines; C003172:poly-gamma-benzyl-L-glutamate; C030315:poly-gamma-methylglutamate; D011099:Polyglutamic Acid; D010206:Papain