title: Lack of association between Y-chromosomal haplogroups and prostate cancer in the Korean population.
abstract: The Y chromosome has recently been suggested to have an association with prostate cancer risk in human populations. Since this chromosome is haploid and lacks recombination over most of its length, haplotypes constructed from binary markers throughout the chromosome can be used for association studies. To assess the possible Y-chromosomal contribution to prostate cancer risk, we have therefore analyzed 14 Y-chromosomal binary markers in 106 prostate cancer cases and 110 controls from the Korean population. In contrast to previous findings in the Japanese population, no statistically significant difference in the distribution of Y-chromosomal haplogroup frequencies was observed between the case and control groups of Koreans. Thus, our data imply that the previously reported associations between Y-chromosomal lineages and a predisposition to, or protection against, prostate cancer might be explained by statistical fluctuations, or by genetic effects that are seen only in some environments.
authors.affiliation: Department of Biological Sciences, Dankook University, Cheonan, Korea. wookkim@dankook.ac.kr
authors.forename: Wook
authors.initials: W
authors.lastname: Kim
authors.forename: Tag-Keun
authors.initials: TK
authors.lastname: Yoo
authors.forename: Sung-Joo
authors.initials: SJ
authors.lastname: Kim
authors.forename: Dong-Jik
authors.initials: DJ
authors.lastname: Shin
authors.forename: Chris
authors.initials: C
authors.lastname: Tyler-Smith
authors.forename: Han-Jun
authors.initials: HJ
authors.lastname: Jin
authors.forename: Kyoung-Don
authors.initials: KD
authors.lastname: Kwak
authors.forename: Eun-Tak
authors.initials: ET
authors.lastname: Kim
authors.forename: Yoon-Sun
authors.initials: YS
authors.lastname: Bae
mesh_terms: D044466:Asian People / Q000235:genetics*; D041322:Chromosomes, Human, Y / Q000235:genetics*; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D005828:Genetics, Population; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D007723:Korea / Q000453:epidemiology; D008297:Male; D011471:Prostatic Neoplasms / Q000453:epidemiology / Q000235:genetics
chemical_list: D005819:Genetic Markers