The prognosis of depression in older patients in general practice and the community. A systematic review.
BACKGROUND
Little is known about the prognosis of depression in older patients in general practice or the community.


OBJECTIVE
To summarize available evidence on the course and prognostic factors of depression in older persons.


METHODS
We conducted a systematic, computerized search of Medline and PsycINFO. Manual search of references of included studies were done. Studies potentially eligible for inclusion were discussed by two reviewers. Methodological quality was independently assessed by two reviewers. Data regarding selection criteria, duration of follow-up, outcome of depression and prognostic factors were extracted.


RESULTS
We identified 40 studies reporting on four cohorts in general practice and 17 in the community. Of all, 67% were of high quality. Follow-up was up to 1 year in general practice and up to 10 years in the community. Information on treatment was hardly provided. About one in three patients developed a chronic course. Five cohorts used more than two measurements during follow-up, illustrating a fluctuating course of depression. Using a best evidence synthesis we summarized the value of prognostic indicators. General practice studies did not provide strong evidence for any factor. Community studies provided strong evidence for an association of baseline depression level, older age, external locus of control, somatic co-morbidity and functional limitations with persistent depression.


CONCLUSIONS
Within the older population, age seems to be a negative prognostic factor, while older people are more likely to be exposed to most of the other prognostic factors identified.
Licht-Strunk
Els
E
Department of General Practice, Institute for Extramural Medicine, VU University Medical Center, Amsterdam, The Netherlands. e.licht@vumc.nl
van der Windt
Daniëlle A W M
DA
van Marwijk
Harm W J
HW
de Haan
Marten
M
Beekman
Aartjan T F
AT
D000368:Aged; D000369:Aged, 80 and over; D003863:Depression / Q000175:diagnosis*; D005194:Family Practice; D005260:Female; D006801:Humans; D008297:Male