title: [Studies on the electron transfer between etoposide (VP-16) and DNA].
abstract: In the present study, the electron transfer between Etoposide (VP-16) and GMP or DNA was investigated using pulse radiolysis and circular dichroism technology. The electron transfer between VP-16 and GMP was found, and the reaction rate constant was determined as 3.16 x 10(7) L x mol(-1) x s(-1) by pulse radiolysis. The authors found the interaction of VP-16 and DNA using the technology of circular dichroism. This study has provided theoretical reference for further study on the anti-tumor mechanism of VP-16.
authors.affiliation: School of Life Science and Technology, Tongji University, Shanghai 200092, China.
authors.forename: Rui
authors.initials: R
authors.lastname: Zhang
authors.forename: Jun
authors.initials: J
authors.lastname: Shi
authors.forename: Shi-long
authors.initials: SL
authors.lastname: Wang
authors.forename: Xiao-yu
authors.initials: XY
authors.lastname: Sun
authors.forename: Chao-jie
authors.initials: CJ
authors.lastname: Zhang
mesh_terms: D002942:Circular Dichroism; D004247:DNA / Q000737:chemistry*; D004579:Electron Transport; D005047:Etoposide / Q000737:chemistry*; D011854:Radiochemistry
chemical_list: D005047:Etoposide; D004247:DNA