title: GARDASIL: prophylactic human papillomavirus vaccine development--from bench top to bed-side.
abstract: GARDASIL (Merck, Whitehouse Station, NJ) is a non-infectious recombinant, quadrivalent vaccine prepared from the highly purified virus-like particles (VLPs) of the major capsid proteins of human papillomavirus (HPV) types 6, 11, 16, and 18. GARDASIL is the first vaccine approved for use in women aged 9-26 years for the prevention of cervical cancer and genital warts, as well as vulvar and vaginal precancerous lesions. This report describes some of the key preclinical efforts, achievements in pharmaceutical development, in vivo animal evaluation, and clinical trial data.
authors.affiliation: Merck Research Laboratories, West Point, Pennsylvania, USA. Li_Shi@merck.com
authors.forename: L
authors.initials: L
authors.lastname: Shi
authors.forename: H L
authors.initials: HL
authors.lastname: Sings
authors.forename: J T
authors.initials: JT
authors.lastname: Bryan
authors.forename: B
authors.initials: B
authors.lastname: Wang
authors.forename: Y
authors.initials: Y
authors.lastname: Wang
authors.forename: H
authors.initials: H
authors.lastname: Mach
authors.forename: M
authors.initials: M
authors.lastname: Kosinski
authors.forename: M W
authors.initials: MW
authors.lastname: Washabaugh
authors.forename: R
authors.initials: R
authors.lastname: Sitrin
authors.forename: E
authors.initials: E
authors.lastname: Barr
mesh_terms: D000293:Adolescent; D000328:Adult; D052685:Alphapapillomavirus / Q000276:immunology*; D000818:Animals; D002648:Child; D002986:Clinical Trials as Topic; D004353:Drug Evaluation, Preclinical / Q000379:methods; D005260:Female; D000068857:Human Papillomavirus Recombinant Vaccine Quadrivalent, Types 6, 11, 16, 18; D006801:Humans; D030361:Papillomavirus Infections / Q000276:immunology / Q000517:prevention & control* / Q000821:virology; D053918:Papillomavirus Vaccines / Q000008:administration & dosage* / Q000276:immunology
chemical_list: D000068857:Human Papillomavirus Recombinant Vaccine Quadrivalent, Types 6, 11, 16, 18; D053918:Papillomavirus Vaccines