Synthesis of 5,6,7,8-tetrahydro-1,6-naphthyridines and related heterocycles by cobalt-catalyzed [2 + 2 + 2] cyclizations.
[reaction: see text] Microwave-promoted, cobalt-catalyzed intramolecular [2 + 2 + 2] cyclizations of dialkynylnitriles successfully gave 5,6,7,8-tetrahydro-1,6-naphthyridines. The efficient synthesis of these relatively simple, yet rarely addressed heterocycles enabled the preparation of a collection of these compounds.
Zhou
Ya
Y
Department of Chemistry and the Center for Methodology and Library Development, Boston University, Boston, Massachusetts 02215, USA.
Porco
John A
JA
Snyder
John K
JK
D000480:Alkynes / Q000737:chemistry; D002384:Catalysis; D003035:Cobalt / Q000737:chemistry*; D003500:Cyclization; D006571:Heterocyclic Compounds / Q000737:chemistry*; D008956:Models, Chemical; D009287:Naphthyridines / Q000138:chemical synthesis*; D009570:Nitriles / Q000737:chemistry; D010084:Oxidation-Reduction; D013237:Stereoisomerism
D000480:Alkynes; D006571:Heterocyclic Compounds; D009287:Naphthyridines; D009570:Nitriles; D003035:Cobalt