title: Detailed site distribution of melanoma and sunlight exposure: aetiological patterns from a Swiss series.
abstract: BACKGROUND
  The relation between detailed cutaneous distribution of melanoma and indicators of sun exposure patterns has scantily been explored in moderately sun-sensitive populations.
  
  
  METHODS
  The precise site of 1658 primary malignant melanoma, registered from 1995 to 2002, in Switzerland were retrieved and clinically validated. Relative melanoma density (RMD) was computed by the ratio of observed to expected number of melanoma allowing for body site surface areas, and further adjusted for site-specific melanocyte density.
  
  
  RESULTS
  Sites of highest risks were the face, shoulder and upper arm for both sexes, the back for men, and leg for women. Major features of this series were: (i) an unexpectedly high RMD for the face in women (5.6 versus 3.7 in men), (ii) the absence of a male predominance for melanoma on the ears and (iii) for the upper limbs, a steady gradient of increasing melanoma density with increasing proximity to the trunk, regardless of sex. Age and sex patterns of RMD parallelled general indicators of sun exposure and behaviour, except for the hand (RMD = 0.2).
  
  
  CONCLUSIONS
  RMD increased with (cumulative) site sun exposure, but a few notable exceptions support the impact of intermittent exposure in melanoma risk.
authors.affiliation: Unité d'épidémiologie du cancer, Institut universitaire de médecine sociale et préventive, rue du Bugnon 17, 1005 Lausanne, Switzerland. jean-luc.bulliard@chuv.ch
authors.forename: J-L
authors.initials: JL
authors.lastname: Bulliard
authors.forename: D
authors.initials: D
authors.lastname: De Weck
authors.forename: T
authors.initials: T
authors.lastname: Fisch
authors.forename: A
authors.initials: A
authors.lastname: Bordoni
authors.forename: F
authors.initials: F
authors.lastname: Levi
mesh_terms: D005260:Female; D006801:Humans; D008297:Male; D008545:Melanoma / Q000209:etiology*; D009381:Neoplasms, Radiation-Induced / Q000209:etiology*; D012727:Sex Characteristics; D012878:Skin Neoplasms / Q000209:etiology*; D013472:Sunlight / Q000009:adverse effects*