Asymmetric hydrogenation of quinolines with high substrate/catalyst ratio.
The chiral diphosphinite ligand derived from (R)-1,1'-spirobiindane-7,7'-diol has been found to be highly effective in the Ir-catalyzed asymmetric hydrogenation of quinolines with high substrate/catalyst ratio (up to 5000) and high enantioselectivity (up to 94% ee).
Tang
Wei-Jun
WJ
Open Laboratory of Chirotechnology of the Institute of Molecular Technology for Drug Discovery and Synthesis and Department of Applied Biology and Chemical Technology, the Hong Kong Polytechnic University, Hong Kong, P. R. China.
Zhu
Shou-Fei
SF
Xu
Li-Jin
LJ
Zhou
Qi-Lin
QL
Fan
Qing-Hua
QH
Zhou
Hai-Feng
HF
Lam
Kimhung
K
Chan
Albert S C
AS