title: Markers of bone turnover are associated with growth and development in young subjects with sickle cell anemia.
abstract: Children with sickle cell anemia (SCA) have low bone mass though bone turnover has not been well described. In this study, growth and pubertal development were assessed twice, 1 year apart, in 80 young subjects with type-SS SCA, while whole body bone mineral content (BMC) and density where measured in a subset (n = 46). Markers of bone turnover were measured at the second visit. Bone formation (alkaline phosphatase) was elevated, whereas bone resorption (deoxypyridinoline) was decreased compared to published data in healthy children. Markers of bone turnover correlated with growth velocity and pubertal development but not with changes in bone mass.
authors.affiliation: Department of Hematology, The Children's Hospital & Research Center, Oakland, California, USA. efung@mail.cho.org
authors.forename: Ellen B
authors.initials: EB
authors.lastname: Fung
authors.forename: Deborah A
authors.initials: DA
authors.lastname: Kawchak
authors.forename: Babette S
authors.initials: BS
authors.lastname: Zemel
authors.forename: Alisha J
authors.initials: AJ
authors.lastname: Rovner
authors.forename: Kwaku
authors.initials: K
authors.lastname: Ohene-Frempong
authors.forename: Virginia A
authors.initials: VA
authors.lastname: Stallings
mesh_terms: D015502:Absorptiometry, Photon; D000293:Adolescent; D000469:Alkaline Phosphatase / Q000097:blood; D000596:Amino Acids / Q000652:urine; D000755:Anemia, Sickle Cell / Q000097:blood* / Q000150:complications / Q000503:physiopathology / Q000652:urine; D015415:Biomarkers; D001835:Body Weight; D015519:Bone Density; D001862:Bone Resorption / Q000097:blood / Q000209:etiology; D002648:Child; D002675:Child, Preschool; D002658:Developmental Disabilities / Q000097:blood / Q000209:etiology; D005260:Female; D006801:Humans; D008297:Male; D015675:Osteocalcin / Q000097:blood; D010024:Osteoporosis / Q000097:blood / Q000209:etiology; D010281:Parathyroid Hormone / Q000097:blood; D011628:Puberty, Delayed / Q000097:blood / Q000209:etiology
chemical_list: D000596:Amino Acids; D015415:Biomarkers; D010281:Parathyroid Hormone; D015675:Osteocalcin; C036020:deoxypyridinoline; D000469:Alkaline Phosphatase