title: Broad-spectrum anti-human immunodeficiency virus (HIV) potential of a peptide HIV type 1 entry inhibitor.
abstract: The AIDS epidemic continues to spread at an alarming rate worldwide, especially in developing countries. One approach to solving this problem is the generation of anti-human immunodeficiency virus (HIV) compounds with inhibition spectra broad enough to include globally prevailing forms of the virus. We have examined the HIV type 1 (HIV-1) envelope specificity of a recently identified entry inhibitor candidate, HNG-105, using surface plasmon resonance spectroscopy and pseudovirus inhibition assays. The combined results suggest that the HNG-105 molecule may be effective across the HIV-1 subtypes, and they highlight its potential as a lead for developing therapeutic and microbicidal agents to help combat the spread of AIDS.
authors.affiliation: Drexel University College of Medicine, 11313 New College Building, 245 N. 15th St., Philadelphia, PA 19102, USA. sc349@drexel.edu
authors.forename: Simon
authors.initials: S
authors.lastname: Cocklin
authors.forename: Hosahudya
authors.initials: H
authors.lastname: Gopi
authors.forename: Bianca
authors.initials: B
authors.lastname: Querido
authors.forename: Manideepthi
authors.initials: M
authors.lastname: Nimmagadda
authors.forename: Syna
authors.initials: S
authors.lastname: Kuriakose
authors.forename: Claudia
authors.initials: C
authors.lastname: Cicala
authors.forename: Sandya
authors.initials: S
authors.lastname: Ajith
authors.forename: Sabine
authors.initials: S
authors.lastname: Baxter
authors.forename: James
authors.initials: J
authors.lastname: Arthos
authors.forename: Julio
authors.initials: J
authors.lastname: Martín-García
authors.forename: Irwin M
authors.initials: IM
authors.lastname: Chaiken
mesh_terms: D019380:Anti-HIV Agents / Q000737:chemistry* / Q000494:pharmacology*; D015699:HIV Envelope Protein gp120 / Q000378:metabolism*; D015497:HIV-1 / Q000187:drug effects*; D015394:Molecular Structure; D010446:Peptide Fragments / Q000378:metabolism*; D013329:Structure-Activity Relationship; D020349:Surface Plasmon Resonance; D053586:Virus Internalization / Q000187:drug effects*
chemical_list: D019380:Anti-HIV Agents; D015699:HIV Envelope Protein gp120; D010446:Peptide Fragments