title: Strong association between HLA-A*0206 and Stevens-Johnson syndrome in the Japanese.
abstract: OBJECTIVE
  To investigate the association between HLA class I antigens and Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) with ocular complications in Japanese.
  
  
  METHODS
  Case-control study.
  
  
  METHODS
  We examined the histocompatibility antigen genes HLA-A, -B, and -C of 40 Japanese SJS/TEN patients with ocular complications and 113 healthy Japanese volunteers by polymerase chain reaction amplification and subsequent hybridization with sequence-specific oligonucleotide probes (PCR-SSO).
  
  
  RESULTS
  We clarified that HLA-A*0206 is strongly associated with SJS/TEN with ocular complications in the Japanese.
  
  
  CONCLUSIONS
  Because this finding is completely different from data reported elsewhere on Taiwanese Han Chinese patients and Caucasian patients, it suggests strong ethnic differences in the HLA-SJS association and points to the need for studies in other ethnic populations in order to obtain a global picture.
authors.affiliation: Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kawaramachi, Kyoto, Japan. mueta@ophth.kpu-m.ac.jp
authors.forename: Mayumi
authors.initials: M
authors.lastname: Ueta
authors.forename: Chie
authors.initials: C
authors.lastname: Sotozono
authors.forename: Katsushi
authors.initials: K
authors.lastname: Tokunaga
authors.forename: Toshio
authors.initials: T
authors.lastname: Yabe
authors.forename: Shigeru
authors.initials: S
authors.lastname: Kinoshita
mesh_terms: D044466:Asian People / Q000208:ethnology; D016022:Case-Control Studies; D003231:Conjunctivitis / Q000208:ethnology / Q000235:genetics*; D005784:Gene Amplification; D005787:Gene Frequency; D005838:Genotype; D015234:HLA-A Antigens / Q000235:genetics*; D015789:HLA-A2 Antigen; D006801:Humans; D017403:In Situ Hybridization; D007564:Japan / Q000453:epidemiology; D015345:Oligonucleotide Probes; D016133:Polymerase Chain Reaction; D013262:Stevens-Johnson Syndrome / Q000208:ethnology / Q000235:genetics*
chemical_list: D015234:HLA-A Antigens; C503735:HLA-A*02:61 antigen; D015789:HLA-A2 Antigen; D015345:Oligonucleotide Probes