title: Effect of antibiotics on Staphylococcus aureus producing Panton-Valentine leukocidin.
abstract: We examined the capacity of Staphylococcus aureus strains to release Panton-Valentine leukocidin (PVL) in the presence of antibiotics. No PVL was detected when S. aureus was incubated at inhibitory concentrations, while subinhibitory concentrations of oxacillin enhanced the PVL level; clindamycin, linezolid, and fusidic acid were inhibitory; and vancomycin had roughly no effect.
authors.affiliation: INSERM, U851, Lyon, France.
authors.forename: Oana
authors.initials: O
authors.lastname: Dumitrescu
authors.forename: Sandrine
authors.initials: S
authors.lastname: Boisset
authors.forename: Cedric
authors.initials: C
authors.lastname: Badiou
authors.forename: Michele
authors.initials: M
authors.lastname: Bes
authors.forename: Yvonne
authors.initials: Y
authors.lastname: Benito
authors.forename: Marie-Elisabeth
authors.initials: ME
authors.lastname: Reverdy
authors.forename: François
authors.initials: F
authors.lastname: Vandenesch
authors.forename: Jerome
authors.initials: J
authors.lastname: Etienne
authors.forename: Gerard
authors.initials: G
authors.lastname: Lina
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001427:Bacterial Toxins / Q000096:biosynthesis / Q000378:metabolism*; D005098:Exotoxins / Q000096:biosynthesis*; D007956:Leukocidins / Q000096:biosynthesis*; D008826:Microbial Sensitivity Tests; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D001427:Bacterial Toxins; D005098:Exotoxins; D007956:Leukocidins; C078284:Panton-Valentine leukocidin