title: Syntheses and pharmacological activities of the derivatives of furanosesquiterpenes from Ligularia virgaurea.
abstract: Four benzofuranosesquiterpenes, 1-hydroxy-2-(3'-pentenyl)-3,7-dimethylbenzofuran (1), 1-hydroxy-2-(3'-pentenyl)-3,7-dimethylbenzofuran (2), cacalol (13), and 1,2-dehydrocacalohastin ( 14) were isolated from the rhizomes of Ligularia virgaurea (Compositae). A lipophilic group and an aqueous-favoring group were introduced to the compounds 1 and 13 to afford twelve new derivatives. Their structures were elucidated by spectroscopic methods. The results of the pharmacological test indicated that some of them can block Ca (++) influx by occupying binding sites of dihydropyridine.
authors.affiliation: School of Pharmaceutical Sciences, Beijing Medical University, Beijing 100083, People's Republic of China.
authors.forename: H M
authors.initials: HM
authors.lastname: Chen
authors.forename: Y Y
authors.initials: YY
authors.lastname: Wang
authors.forename: J M
authors.initials: JM
authors.lastname: Mao
authors.forename: M S
authors.initials: MS
authors.lastname: Cai
authors.forename: Z J
authors.initials: ZJ
authors.lastname: Jia