title: Percutaneous transluminal angioplasty is feasible and effective in patients on chronic dialysis with severe peripheral artery disease.
abstract: BACKGROUND
  Peripheral arterial disease (PAD) is common among patients on chronic dialysis. Despite severe clinical manifestations, the indication for bypass surgery is controversial, because of the high morbidity and mortality rate of these patients. The less invasive percutaneous transluminal angioplasty (PTA) is a possible alternative, but data about PTA in dialysis patients are scarce.
  
  
  METHODS
  We followed 107 dialysis patients (mean age 67+/-10, 75 males) with 132 ischaemic limbs (97% with critical limb ischaemia and ischaemic foot lesions or rest pain) consecutively treated by PTA.
  
  
  RESULTS
  PTA was successful in 97% of cases. Median follow-up was 22 months. Cumulative limb salvage rates at 12, 24, 36 and 48 months were 86, 84, 84 and 62%, respectively. Log-rank test showed an association between major amputation and baseline presence of foot lesions (P=0.04). This association was confirmed by a Cox survival multivariate analysis [hazard ratio (HR)=7.03, 95% confidence interval (CI)=1.1-43.0, P=0.035]. Limb salvage without any new intervention on the same leg was achieved in 70% of the cases, and was associated with the absence of diabetes mellitus (P=0.01), lower number of treated lesions (P=0.04) and proximal level (iliac and/or femoro-popliteal) of PTA (P<0.001). Independent predictors were diabetes mellitus (HR=3.47, 95% CI=1.31-9.17, P=0.01) and proximal PTA (HR=0.28, 95% CI=0.08-0.94, P=0.04). Fifty-three (49%) patients died during follow-up. Patients older than 67 years (the median value in our sample) had a 2.4-fold increase in mortality risk (95% CI=1.4-4.1, P<0.001).
  
  
  CONCLUSIONS
  PTA is feasible and effective in dialysis patients with PAD, and should be preferred to other more invasive interventions.
authors.affiliation: Servizio di Emodinamica, Istituto Clinico Città di Brescia, Via Gualla 15, 25123 Brescia, Italy. langrazi@tin.it
authors.forename: Lanfroi
authors.initials: L
authors.lastname: Graziani
authors.forename: Antonio
authors.initials: A
authors.lastname: Silvestro
authors.forename: Vittorio
authors.initials: V
authors.lastname: Bertone
authors.forename: Ermanna
authors.initials: E
authors.lastname: Manara
authors.forename: Alberto
authors.initials: A
authors.lastname: Alicandri
authors.forename: Giovanni
authors.initials: G
authors.lastname: Parrinello
authors.forename: Annunciata
authors.initials: A
authors.lastname: Manganoni
mesh_terms: D000368:Aged; D000800:Angioplasty, Balloon / Q000009:adverse effects / Q000379:methods*; D005260:Female; D006801:Humans; D007511:Ischemia / Q000628:therapy; D007676:Kidney Failure, Chronic / Q000628:therapy*; D023821:Limb Salvage / Q000379:methods; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016491:Peripheral Vascular Diseases / Q000209:etiology / Q000628:therapy*; D006435:Renal Dialysis / Q000009:adverse effects*