title: Absence of lumpy skin disease virus in semen of vaccinated bulls following vaccination and subsequent experimental infection.
abstract: Twelve serologically negative bulls were used, six were vaccinated with a modified live LSD vaccine and six unvaccinated. All were then experimentally infected with a virulent field strain of LSDV. No clinical abnormality was detected following vaccination, and mild clinical signs were seen in four vaccinated bulls following challenge. Virus was not found in semen of vaccinated bulls. Two of the unvaccinated bulls developed severe LSD and four showed mild symptoms, all excreted the virus in the semen following challenge. This study confirmed the ability of LSD vaccination to prevent the excretion of LSDV in semen of vaccinated bulls.
authors.affiliation: Section of Reproduction, Department of Production Animal Studies, Faculty of Veterinary Science, University of Pretoria, Onderstepoort 0110, South Africa.
authors.forename: U I
authors.initials: UI
authors.lastname: Osuagwuh
authors.forename: V
authors.initials: V
authors.lastname: Bagla
authors.forename: E H
authors.initials: EH
authors.lastname: Venter
authors.forename: C H
authors.initials: CH
authors.lastname: Annandale
authors.forename: P C
authors.initials: PC
authors.lastname: Irons
mesh_terms: D000818:Animals; D002417:Cattle; D004279:DNA, Viral / Q000032:analysis; D008166:Lumpy Skin Disease / Q000188:drug therapy / Q000276:immunology* / Q000821:virology; D008167:Lumpy skin disease virus / Q000235:genetics / Q000276:immunology* / Q000472:pathogenicity; D008297:Male; D016133:Polymerase Chain Reaction; D012661:Semen / Q000187:drug effects / Q000821:virology*; D014611:Vaccination / Q000379:methods*; D014765:Viral Vaccines / Q000276:immunology* / Q000627:therapeutic use; D014774:Virulence
chemical_list: D004279:DNA, Viral; D014765:Viral Vaccines