Clozapine for the treatment of neurogenic bladder.
Neurogenic bladder leading to urinary incontinence has been described in patients of stroke, dementia, Parkinson's disease, and some schizophrenia cases with cognitive impairment possibly due to impaired cortical inhibition of the urinary bladder. The underlying brain abnormalities for urinary incontinence are similar in such cases. We report here such a case of neurogenic bladder responding to treatment with clozapine. The possible mechanism of action and clinical implications are described.
Kumar
Amardeep
A
Department of Psychiatry, All India Institute of Medical Sciences (AIIMS), New Delhi, India.
Chadda
R K
RK
Department of Psychiatry, All India Institute of Medical Sciences (AIIMS), New Delhi, India.
Kumar
Nand
N
Department of Psychiatry, All India Institute of Medical Sciences (AIIMS), New Delhi, India.
Balan
Sabish
S
Department of Psychiatry, All India Institute of Medical Sciences (AIIMS), New Delhi, India.
Prakash Srinivasan
Shiva
S
Department of Psychiatry, All India Institute of Medical Sciences (AIIMS), New Delhi, India.
D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D003024:Clozapine / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D011877:Radionuclide Imaging; D012559:Schizophrenia / Q000150:complications / Q000188:drug therapy; D012565:Schizophrenic Psychology; D001750:Urinary Bladder, Neurogenic / Q000000981:diagnostic imaging / Q000188:drug therapy*; D053202:Urinary Incontinence, Urge / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy; D014563:Urodynamics
D014150:Antipsychotic Agents; D003024:Clozapine