title: Hemodynamic consequences of thoracic artificial lung attachment configuration: a computational model.
abstract: A thoracic artificial lung (TAL) is being developed to assist treatment of acute and chronic pulmonary dysfunction. The TAL is attached directly to the pulmonary circulation. Depending on pathophysiology, the TAL may be attached in series with the natural lungs (NLs), in parallel with the NLs, or in an intermediate, hybrid configuration. We developed a computational model to study hemodynamic consequences of TAL attachment configuration under pathologic conditions. The pulmonary and systemic circulations, heart, and TAL are modeled as interconnected compliances and conductances, some valved. Time-varying cardiac compliance drives the system and generates pressures and flow rates. The model includes blood pressure feedback from the sympathetic nervous system, renin-angiotensin system, and renal volume control mechanism. We used previously published results from porcine experiments to verify model accuracy. We modeled normal physiology and four disease states. A hybrid configuration with 100% cardiac output through the TAL and 40% through the NLs would deliver maximal blood flow, 3.6 to 4.6 l/min, to the TAL and be tolerated by the right ventricle. Additionally, the model suggests that reducing the large "minor loss" resistances at the graft anastomoses to the pulmonary artery would improve the hemodynamics of all TAL attachment configurations.
authors.affiliation: Department of Physiology and Cellular Biophysics, Columbia University, New York, New York, USA.
authors.forename: Carrie E
authors.initials: CE
authors.lastname: Perlman
authors.forename: Lyle F
authors.initials: LF
authors.lastname: Mockros
mesh_terms: D000818:Animals; D001187:Artificial Organs; D001783:Blood Flow Velocity; D001794:Blood Pressure; D006339:Heart Rate; D006801:Humans; D008168:Lung; D008171:Lung Diseases / Q000503:physiopathology / Q000628:therapy; D008433:Mathematics; D008875:Middle Aged; D008954:Models, Biological; D009206:Myocardium / Q000378:metabolism; D010100:Oxygen / Q000378:metabolism; D013552:Swine; D014655:Vascular Resistance
chemical_list: D010100:Oxygen