Preparation of cross-linked poly[(epsilon-caprolactone)-co-lactide] and biocompatibility studies for tissue engineering materials.
In this study, cross-linked materials were prepared using the branched macromonomer with different CL/LA molar ratios, and feasibility studies for tissue engineering were carried out. The thermal and mechanical properties of these materials depended on the CL/LA compositions; however, there was no change in the wettability of each material. The HeLa cells adhesion and growth on the CL-LA7030c were equal to that on the commercially available polystyrene dish. The protein absorption experiment using the FBS proteins revealed that the materials with well-grown cells showed better adhesion of the proteins. [photo: see text]
Miyasako
Hiroshi
H
Department of Nanostructure and Advanced Materials, Graduate School of Science and Engineering, Kagoshima University, 1-21-40 Korimoto, Kagoshima 890-0065, Japan.
Yamamoto
Kazuya
K
Nakao
Aiko
A
Aoyagi
Takao
T
D000327:Adsorption; D001672:Biocompatible Materials; D002448:Cell Adhesion; D002455:Cell Division; D003432:Cross-Linking Reagents / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D011091:Polyesters / Q000737:chemistry*; D011506:Proteins / Q000737:chemistry; D013499:Surface Properties; D023822:Tissue Engineering / Q000379:methods*
D001672:Biocompatible Materials; D003432:Cross-Linking Reagents; D011091:Polyesters; D011506:Proteins; C062968:lactide-caprolactone copolymer