title: [Atherothrombosis: transposition of the models to the clinic and reciprocally].
abstract: The transposition of experimental models to clinical situations in the atherothrombosis field will be illustrated by two examples: in one hand, the steps of the discovery of drugs such as ticlopidine and clopidogrel, the identification of their molecular targets on blood platelets and the pharmacological consequences of these developments; on the other hand, the setting up of a model of localized arterial thrombosis in mice, with two degrees of severity which react differentially to antithrombotic drugs. The main features of these models will be compared to clinical situations such as unstable angina and myocardial infarction.
authors.affiliation: INSERM U 311, EFS Alsace, Strasbourg, France. christian.gachet@efs-alsace.fr
authors.forename: Christian
authors.initials: C
authors.lastname: Gachet
authors.forename: Béatrice
authors.initials: B
authors.lastname: Hechler
authors.forename: Christelle
authors.initials: C
authors.lastname: Nonne
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Cazenave
authors.forename: François
authors.initials: F
authors.lastname: Lanza
authors.forename: Boris
authors.initials: B
authors.lastname: Aleil
mesh_terms: D000818:Animals; D050197:Atherosclerosis / Q000503:physiopathology*; D005343:Fibrinolytic Agents / Q000627:therapeutic use; D006801:Humans; D051379:Mice; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use; D013927:Thrombosis / Q000503:physiopathology* / Q000517:prevention & control
chemical_list: D005343:Fibrinolytic Agents; D010975:Platelet Aggregation Inhibitors