The scoop on Sco.
In the January 3 issue of Cell Metabolism, report that the mitochondrial metallochaperones Sco1 and Sco2, essential for cytochrome c oxidase assembly, are also responsible for maintenance of cell copper homeostasis, thus showing a new function of mitochondria.
Brière
Jean-Jacques
JJ
Department of Biological Sciences, Columbia University, New York, NY 10027, USA.
Tzagoloff
Alexander
A
D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism*; D003300:Copper / Q000378:metabolism; D003576:Electron Transport Complex IV / Q000378:metabolism; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism*; D024101:Mitochondrial Proteins / Q000235:genetics / Q000378:metabolism*; D008954:Models, Biological; D018832:Molecular Chaperones
D002352:Carrier Proteins; D008565:Membrane Proteins; D024101:Mitochondrial Proteins; D018832:Molecular Chaperones; C489345:SCO1 protein, human; C400285:SCO2 protein, human; D003300:Copper; C117108:cytochrome C oxidase subunit II; D003576:Electron Transport Complex IV