E/Z-rubrolide O, an anti-inflammatory halogenated furanone from the New Zealand ascidian Synoicum n. sp.
Bioassay-directed fractionation of extracts of a Synoicum n. sp. ascidian from New Zealand led to the isolation of the principal anti-inflammatory component, which was identified by spectroscopic methods as a new member of the rubrolide family, rubrolide O (1), existing as a mixture of E/Z isomers.
Pearce
A Norrie
AN
TerraMarine Pharmaceuticals, Department of Chemistry, The University of Auckland, Private Bag 92019, Auckland, New Zealand.
Chia
Elizabeth W
EW
Berridge
Michael V
MV
Maas
Elizabeth W
EW
Page
Michael J
MJ
Webb
Victoria L
VL
Harper
Jacquie L
JL
Copp
Brent R
BR
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D006846:Hydrocarbons, Halogenated / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D015394:Molecular Structure; D009504:Neutrophils / Q000378:metabolism; D009520:New Zealand; D013237:Stereoisomerism; D014561:Urochordata / Q000737:chemistry*
D000893:Anti-Inflammatory Agents; D005663:Furans; D006846:Hydrocarbons, Halogenated; C517714:rubrolide O