[Establishment and evaluation on the animal model of vestibular compensation].
OBJECTIVE
To establish and evaluate the vestibular compensation model in rat.


METHODS
The labyrinth of left ear of rat was destructed with the method of operation and chemical labyrinth destruction. After the unilateral vestibular function was lost, spontaneous nystagmus(SN), head deviation( HD) and postural asymmetries (PA) were observed at a series of time points after operation.


RESULTS
The degree of PA changed along with the time.


CONCLUSIONS
Operation and chemical labyrinth destruction may provide a good method to establish the animal model of vestibular compensation.
Zhang
Yaming
Y
Department of Otolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Kong
Weijia
W
Liu
Jun
J
D000818:Animals; D004195:Disease Models, Animal; D051381:Rats; D017208:Rats, Wistar; D014724:Vestibular Function Tests; D014722:Vestibule, Labyrinth / Q000503:physiopathology*