Synthesis of a nanostructured star block copolymer with a cyclotriphosphazene core.
An amphiphilic star block copolymer of poly(L-lactic acid)-b-poly(ethylene glycol) (PLLA-b-PEG) was synthesized using a hexachlorocyclotriphosphazene ring (N3P3Cl6) as a core. N3P3(OC6H4-p-CHO)6 was prepared by the reaction between the hexachlorocyclotriphosphazene core and 4-hydroxybenzaldehyde sodium salt. N3P3(OC6H4-p-CH2OH)6 was then obtained by reduction of N3P3(OC6H4-p-CHO)6. N3P3(OC6H4-p-CH2OH)6 was used as an initiator to obtain a PLLA-grafted star branched polymer by polymerizing lactide, which was then treated with succinic acid to produce a carboxylated PLLA-grafted star polymer. PEG blocks were attached to a carboxylated PLLA-grafted star polymer to produce an amphiphilic PLLA-b-PEG-grafted star block polymer by additional esterification with poly(ethylene glycol methyl ether).
Han
Jae Kook
JK
Department of Polymer Science and Engineering, Inha University, Incheon 402-751, Korea.
Kim
Sung Tae
ST
Kim
Hyun Jung
HJ
Kwon
Yong Ku
YK
D001672:Biocompatible Materials; D002208:Caproates / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry; D019344:Lactic Acid / Q000737:chemistry*; D046911:Macromolecular Substances; D009682:Magnetic Resonance Spectroscopy; D018625:Microscopy, Atomic Force; D008855:Microscopy, Electron, Scanning; D008956:Models, Chemical; D008968:Molecular Conformation; D053758:Nanoparticles / Q000737:chemistry*; D036103:Nanotechnology / Q000295:instrumentation / Q000379:methods*; D011091:Polyesters; D011092:Polyethylene Glycols / Q000737:chemistry; D011100:Polyglycolic Acid / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*; D013696:Temperature
D001672:Biocompatible Materials; D002208:Caproates; D004337:Drug Carriers; D046911:Macromolecular Substances; D011091:Polyesters; D011108:Polymers; D011100:Polyglycolic Acid; D019344:Lactic Acid; D011092:Polyethylene Glycols; C033616:poly(lactide)