title: [Immune response to HSP70-HBcAg(18-27) complex in HBV transgenic mice].
abstract: OBJECTIVE
  To study the cellular immune response to HSP70-HBcAg(18-27) complex in HBV transgenic mice.
  
  
  METHODS
  HSP70-HBcAg(18-27) complex was reconstituted in vitro, then it was injected into HBV transgenic mice to observe the cellular immune response. At the same time, we investigated whether HSP70-HBcAg(18-27) complex could generate antigen specific cytotoxic T lymphocyte responses in spleen cells.
  
  
  RESULTS
  Our results demonstrated that HSP70-HBcAg(18-27) complex increased levels of CD4+ and CD8+ T cells in the spleens and peripheral blood of HBV transgenic mice, and the complex also activated dendritic and natural killer cells.
  
  
  CONCLUSIONS
  HSP70-HBcAg(18-27) complex has an immunological antigenicity in raising the immunoresponse to chronic HBV infection in HBV transgenic mice. HSP70-HBcAg(18-27) complex might be considered as a candidate for further studies on its role as a therapeutic vaccine against chronic HBV infection in humans.
authors.affiliation: Key Laboratory of Molecular Biology for Infectious Diseases, PRC Ministry of Education, Institute for Viral Hepatitis, Chongqing University of Medical Sciences, Chongqing 400010, China.
authors.forename: Huai-dong
authors.initials: HD
authors.lastname: Hu
authors.forename: Peng
authors.initials: P
authors.lastname: Hu
authors.forename: Guo-lin
authors.initials: GL
authors.lastname: Chen
authors.forename: Ming-li
authors.initials: ML
authors.lastname: Peng
authors.forename: Min
authors.initials: M
authors.lastname: Chen
authors.forename: Hong
authors.initials: H
authors.lastname: Ren
mesh_terms: D000818:Animals; D005260:Female; D018840:HSP70 Heat-Shock Proteins / Q000276:immunology*; D006512:Hepatitis B Core Antigens / Q000276:immunology*; D006515:Hepatitis B virus / Q000235:genetics / Q000276:immunology*; D008297:Male; D051379:Mice; D008822:Mice, Transgenic; D013154:Spleen / Q000276:immunology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*
chemical_list: D018840:HSP70 Heat-Shock Proteins; D006512:Hepatitis B Core Antigens