Synthesis and structure evaluation of a novel cantharimide and its cytotoxicity on SK-Hep-1 hepatoma cells.
A remarkable control of the potency of cantharimide is described based on the electronic properties of functional group and it exhibits a relatively less toxic effect to the non-malignant hematological disorder bone marrow cells.
Kok
Stanton Hon Lung
SH
Lo Ka Chung Centre for Natural Anti-Cancer Drug Development, Institute of Molecular Technology for Drug Discovery and Synthesis, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong, PR China.
Chui
Chung Hin
CH
Lam
Wing Sze
WS
Chen
Jien
J
Lau
Fung Yi
FY
Wong
Raymond Siu Ming
RS
Cheng
Gregory Yin Ming
GY
Lai
Paul Bo San
PB
Leung
Thomas Wai Tong
TW
Yu
Michael Wing Yiu
MW
Tang
Johnny Cheuk On
JC
Chan
Albert Sun Chi
AS
D000970:Antineoplastic Agents; D001854:Bone Marrow Cells / Q000187:drug effects; D002193:Cantharidin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000633:toxicity*; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy* / Q000473:pathology; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D004583:Electrons; D006801:Humans; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D002193:Cantharidin