Shaping a helper T cell identity.
Cell fate 'decisions' involving multipotential progenitors seem to be 'dictated' by threshold activities of lineage-determining transcription factors. Such 'decisions' are now shown to be reinforced by the induction of secondary transcription factors that act in concert with the primary regulators.
Singh
Harinder
H
D002454:Cell Differentiation; D019070:Cell Lineage; D053263:Gene Regulatory Networks; D006377:T-Lymphocytes, Helper-Inducer / Q000166:cytology* / Q000276:immunology / Q000378:metabolism*