title: Hypoxia-selective antitumor agents: norsesterterpene peroxides from the marine sponge Diacarnus levii preferentially suppress the growth of tumor cells under hypoxic conditions.
abstract: As part of an ongoing research program to discover natural products that suppress the hypoxia-activated tumor survival pathways, the lipid extract of the Papua New Guinea marine sponge Diacarnus levii was found to suppress hypoxia-induced HIF-1 activation and hypoxic tumor cell survival. Bioassay-guided isolation of D. levii yielded four new norsesterterpene peroxides, diacarnoxides A - D. Diacarnoxide B exhibits a significantly enhanced ability to suppress the growth of tumor cells under hypoxic conditions.
authors.affiliation: Department of Pharmacognosy, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, Mississippi 38677-1848, USA.
authors.forename: Jingqiu
authors.initials: J
authors.lastname: Dai
authors.forename: Yang
authors.initials: Y
authors.lastname: Liu
authors.forename: Yu-Dong
authors.initials: YD
authors.lastname: Zhou
authors.forename: Dale G
authors.initials: DG
authors.lastname: Nagle
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D000860:Hypoxia; D051793:Hypoxia-Inducible Factor 1 / Q000187:drug effects* / Q000378:metabolism; D008386:Marine Biology; D015394:Molecular Structure; D010219:Papua New Guinea; D011161:Porifera / Q000737:chemistry*; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D051793:Hypoxia-Inducible Factor 1; D013729:Terpenes