title: [Diagnosis and treatment of gastrointestinal stromal tumors: report of 135 cases].
abstract: OBJECTIVE
  To analyze the relationships between smooth-muscle tumors of gastrointestinal (GI) tract and gastrointestinal stromal tumors (GISTs), and the efficacy of surgical management.
  
  
  METHODS
  The clinical and pathological data of 135 cases of GISTs were collected, including cases of leiomyomas/leiomyosarcoma between 1993 and 2003 and GIST between Jan. 2000 and Jul. 2005. The surgical outcomes were analyzed retrospectively.
  
  
  RESULTS
  82.1% of former leiomyomas/leiomyosarcomas was corrected to GISTs. Overall 5-year survival rate was 79.7%. Univariate analysis revealed preoperative metastasis, tumor size, mitotic index, and postoperative metastasis or recurrence were correlated with overall survival in patients with completed resection. Multivariate analysis showed that only postoperative metastasis or recurrence were the indicators of poor prognosis, but without statistical significance (P=0.064). However, multivariate analysis for disease-free survival showed that preoperative metastasis and mitotic index were two independent predictors of poor prognosis (P=0.001 and P<0.001).
  
  
  CONCLUSIONS
  Most former leiomyomas/leiomyosarcomas of GI tract should be corrected to the diagnosis of GISTs. Complete surgical resection is the choice of treatment for GISTs. Preoperative metastasis and mitotic index are two independent predictors of poor prognosis.
authors.affiliation: Department of Gastrointestinopancreatic Surgery, The First Affiliated Hospital, Sun Yet-sen University, Guangzhou 510080, China.
authors.forename: Xin-Hua
authors.initials: XH
authors.lastname: Zhang
authors.forename: Yu-Long
authors.initials: YL
authors.lastname: He
authors.forename: Wen-Hua
authors.initials: WH
authors.lastname: Zhan
authors.forename: Shi-Rong
authors.initials: SR
authors.lastname: Cai
authors.forename: Chang-Hua
authors.initials: CH
authors.lastname: Zhang
mesh_terms: D005260:Female; D046152:Gastrointestinal Stromal Tumors / Q000175:diagnosis* / Q000601:surgery*; D006801:Humans; D008297:Male; D011379:Prognosis; D015996:Survival Rate