title: Serological test and chest computed tomography findings in patients with Mycobacterium avium complex lung disease.
abstract: The present authors have previously reported the usefulness of a serodiagnostic test to detect serum glycopeptidolipid (GPL) core antibody in diagnosing Mycobacterium avium complex (MAC) lung disease in immunocompetent patients. The aim of the present study was to investigate correlations between the levels of antibody against GPL core and chest computed tomography (CCT) findings in patients with MAC lung disease. A total of 47 patients with MAC-positive culture from their sputum and who had radiographic abnormalities were investigated. Thirty-three patients met the American Thoracic Society criteria for MAC disease; 14 did not. All patients underwent both CCT examination and the serodiagnostic test for MAC at the same time. Small nodular shadows were seen on CCT in all 47 patients and bronchiectasis shadows were seen in 39 (83%) of them. There was a significant positive correlation between the extent of the disease and the level of GPL core immunoglobulin (Ig)A antibody. The levels of GPL core IgA antibody were significantly elevated in patients who had nodular shadows (10-30 mm) compared with patients who had small nodular shadows (<10 mm). The present results document that the levels of immunoglobulin A antibody against glycopeptidolipid core correlate with the chest computed tomography findings of Mycobacterium avium complex lung disease.
authors.affiliation: Department of Internal Medicine, National Hospital Organization National Toneyama Hospital, 5-1-1 Toneyama, Toyonaka-shi, Osaka 560-8552, Japan. kitadas@toneyama.hosp.go.jp
authors.forename: S
authors.initials: S
authors.lastname: Kitada
authors.forename: Y
authors.initials: Y
authors.lastname: Nishiuchi
authors.forename: T
authors.initials: T
authors.lastname: Hiraga
authors.forename: N
authors.initials: N
authors.lastname: Naka
authors.forename: H
authors.initials: H
authors.lastname: Hashimoto
authors.forename: K
authors.initials: K
authors.lastname: Yoshimura
authors.forename: K
authors.initials: K
authors.lastname: Miki
authors.forename: M
authors.initials: M
authors.lastname: Miki
authors.forename: M
authors.initials: M
authors.lastname: Motone
authors.forename: T
authors.initials: T
authors.lastname: Fujikawa
authors.forename: K
authors.initials: K
authors.lastname: Kobayashi
authors.forename: I
authors.initials: I
authors.lastname: Yano
authors.forename: R
authors.initials: R
authors.lastname: Maekura
mesh_terms: D000368:Aged; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006017:Glycolipids / Q000737:chemistry; D006801:Humans; D007070:Immunoglobulin A / Q000737:chemistry; D008171:Lung Diseases / Q000382:microbiology*; D008297:Male; D008875:Middle Aged; D009164:Mycobacterium Infections / Q000378:metabolism*; D009165:Mycobacterium Infections, Nontuberculous / Q000175:diagnosis*; D015269:Mycobacterium avium Complex / Q000378:metabolism*; D013902:Radiography, Thoracic / Q000379:methods*; D012698:Serologic Tests; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D006017:Glycolipids; D007070:Immunoglobulin A