Cytotoxic constituents of the stems of Cinnamomum subavenium.
The aim of this study was to evaluate the cytotoxic effects of three new butanolides, subamolides A - C (1-3), and a new secobutanolide, secosubamolide (4), on the human colorectal cancer cell line SW480. Compounds 1-4 are new and were isolated from the stems of Cinnamomum subavenium, along with 17 known compounds. The structures of 1-4 were determined by spectroscopic analysis. Propidium iodide staining and flow cytometry were used to evaluate DNA damage of the treated SW480 cells, and it was found that 1-4 caused DNA damage in a dose-dependent manner after 24 h of treatment.
Chen
Chung-Yi
CY
Basic Medical Science Education Center, Fooyin University, Kaohsiung County 831, Taiwan, Republic of China. xx377@ mail.fy.edu.tw
Chen
Ching-Hsein
CH
Wong
Chung-Hang
CH
Liu
Yi-Wen
YW
Lin
Yu-Shan
YS
Wang
Yau-Der
YD
Hsui
Yen-Ray
YR
D015107:4-Butyrolactone / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D027424:Cinnamomum / Q000737:chemistry*; D004249:DNA Damage / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D015394:Molecular Structure; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*
D000972:Antineoplastic Agents, Phytogenic; C517710:subamolide A; C517712:subamolide B; C517713:subamolide C; D015107:4-Butyrolactone