Postmenopausal virilization after spousal use of topical androgens.
OBJECTIVE
To increase awareness of the potential to cause virilization in postmenopausal woman secondary to a spouse's use of topical androgen.


METHODS
Case report.


METHODS
University-affiliated teaching hospital.


METHODS
A 63-year-old postmenopausal woman with virilization.


METHODS
Removal of the source of androgen exposure.


METHODS
Regression of the biochemical and physical signs of androgen excess in a woman after cessation of T gel use by her partner, and reinitiation of use with precautions against potential methods of transfer.


RESULTS
This case highlights the unintentional transdermal absorption of testosterone sufficient to induce virilization in a couple who were aware of this potential problem. The apparent source of androgen absorption was a washcloth that the couple shared. The diagnosis can be established with a detailed history and a few blood tests (total and free T, and DHEAS) to exclude other sources of androgens.


CONCLUSIONS
This report reinforces the need to consider exogenous androgen exposure in the differential diagnosis of virilization in adults when the more common causes have been excluded.
Merhi
Zaher O
ZO
Maimonides Medical Center, Brooklyn, New York 11219, USA. zom00@hotmail.com
Santoro
Nanette
N
D000287:Administration, Topical; D000728:Androgens / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017698:Postmenopause; D012869:Skin Absorption; D018454:Spouses; D014770:Virilism / Q000209:etiology*
D000728:Androgens