Nup88 expression in normal mucosa, adenoma, primary adenocarcinoma and lymph node metastasis in the colorectum.
OBJECTIVE
It was the aim of this study to investigate Nup88 expression in normal colorectal mucosa, adenoma, adenocarcinoma and lymph node metastasis, as well as the relationship between Nup88 expression and clinicopathological features.


METHODS
Nup88 expression was examined by immunohistochemistry in 84 normal mucosa samples, 32 adenomas, 181 primary adenocarcinomas, and 18 lymph node metastases from colorectal tumour patients.


RESULTS
Nup88 expression was observed in normal epithelial and tumour cells. The frequency of strong Nup88 expression was increased from normal mucosa or adenoma to primary tumour and lymph node metastasis (p < 0.0001). There was no significant difference in the expression between normal mucosa and adenoma (p = 0.41). The frequency of strong Nup88 expression was higher in ulcerated tumours (40%) than in polypoid/large fungating tumours (23%; p = 0.048). The frequency of strong Nup88 expression was significantly different among tumours with good (21%), moderate (42%) and poor differentiation (48%; p = 0.01). Nup88 expression was not related to the patients' gender, age, tumour location, size, histological type, invasive depth, lymph node status and Dukes stage (p > 0.05).


CONCLUSIONS
Our results suggest that Nup88 may play a role during the development, aggressiveness and differentiation of colorectal tumours.
Zhang
Zhi-Yong
ZY
Department of Pathology, Tangshan Worker's Hospital, Tangshan, China.
Zhao
Zeng-Ren
ZR
Jiang
Li
L
Li
Jia-Chen
JC
Gao
Yan-Min
YM
Cui
Dong-Sheng
DS
Wang
Che-Jiang
CJ
Schneider
Jose
J
Wang
Ming-Wei
MW
Sun
Xiao-Feng
XF
D000230:Adenocarcinoma / Q000378:metabolism* / Q000556:secondary; D000236:Adenoma / Q000378:metabolism*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor; D015179:Colorectal Neoplasms / Q000378:metabolism* / Q000473:pathology; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism* / Q000473:pathology; D008198:Lymph Nodes / Q000378:metabolism; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D028861:Nuclear Pore Complex Proteins / Q000378:metabolism*
D014408:Biomarkers, Tumor; C104835:NUP88 protein, human; D028861:Nuclear Pore Complex Proteins