title: Ultra-high speed and ultra-high resolution spectral-domain optical coherence tomography and optical Doppler tomography in ophthalmology.
abstract: We present ultra-high resolution optical coherence tomography (OCT) structural intensity and optical Doppler tomography (ODT) flow velocity images of the human retina in vivo. The ultra-high speed OCT system is based on Spectral Domain or Fourier Domain technology, which provides a sensitivity advantage over conventional OCT of more than 2 orders of magnitude. This sensitivity improvement allows video rate OCT and ODT cross sectional imaging of retinal structures. Images will be presented with axial resolutions of 6 and 3.5 microns. We observed small features in the inner and outer plexiform layers, which are believed to be small blood vessels. Flow velocity images will be presented showing pulsatile flow in retinal arteries and veins.
authors.affiliation: Harvard Medical School, Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA.
authors.forename: B
authors.initials: B
authors.lastname: Cense
authors.forename: T C
authors.initials: TC
authors.lastname: Chen
authors.forename: N
authors.initials: N
authors.lastname: Nassif
authors.forename: M C
authors.initials: MC
authors.lastname: Pierce
authors.forename: S H
authors.initials: SH
authors.lastname: Yun
authors.forename: B H
authors.initials: BH
authors.lastname: Park
authors.forename: B E
authors.initials: BE
authors.lastname: Bouma
authors.forename: G J
authors.initials: GJ
authors.lastname: Tearney
authors.forename: J F
authors.initials: JF
authors.lastname: de Boer
mesh_terms: D003952:Diagnostic Imaging / Q000295:instrumentation / Q000379:methods; D003941:Diagnostic Techniques, Ophthalmological / Q000295:instrumentation*; D006801:Humans; D017078:Laser-Doppler Flowmetry; D009898:Optic Disk / Q000033:anatomy & histology / Q000166:cytology; D012016:Reference Values; D012039:Regional Blood Flow; D012171:Retinal Vessels / Q000033:anatomy & histology*; D041623:Tomography, Optical Coherence / Q000295:instrumentation* / Q000379:methods*