title: [Cardioversion of amiodarone-insensitive atrial fibrillation by bepridil in heart failure: two case reports].
abstract: Two patients presented with atrial fibrillation which was refractory to amiodarone but successfully treated with bepridil. A 76-year-old man with ischemic cardiomyopathy, non-sustained ventricular tachycardia (NSVT) and atrial fibrillation received amiodarone for NSVT, which disappeared but atrial fibrillation was sustained. A month after receiving amiodarone, interstitial pneumonia occurred. Interstitial pneumonia was improved after amiodarone was discontinued, but NSVT occurred again. He received bepridil, when NSVT and atrial fibrillation disappeared. An 83-year-old man with dilated cardiomyopathy, NSVT, and atrial fibrillation received amiodarone for NSVT, which disappeared but atrial fibrillation was sustained. Five months after receiving amiodarone, interstitial pneumonia occurred. Interstitial pneumonia was improved after amiodarone was discontinued, but NSVT occurred again. He received bepridil, when NSVT and atrial fibrillation disappeared.
authors.affiliation: Division of Cardiology, Tokuyama Central Hospital, Kouda-cho 1-1, Shunan, Yamaguchi 745-8522. kimura@mu.0038.net
authors.forename: Masayasu
authors.initials: M
authors.lastname: Kimura
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ogawa
authors.forename: Takatoshi
authors.initials: T
authors.lastname: Wakeyama
authors.forename: Akira
authors.initials: A
authors.lastname: Takaki
authors.forename: Takahiro
authors.initials: T
authors.lastname: Iwami
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Hadano
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Miyazaki
authors.forename: Akihiko
authors.initials: A
authors.lastname: Shimizu
authors.forename: Masunori
authors.initials: M
authors.lastname: Matsuzaki
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000638:Amiodarone / Q000008:administration & dosage / Q000009:adverse effects; D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage*; D001281:Atrial Fibrillation / Q000150:complications / Q000188:drug therapy*; D015764:Bepridil / Q000008:administration & dosage*; D002311:Cardiomyopathy, Dilated / Q000150:complications / Q000188:drug therapy; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000139:chemically induced; D008297:Male; D017180:Tachycardia, Ventricular / Q000150:complications / Q000188:drug therapy
chemical_list: D000889:Anti-Arrhythmia Agents; D015764:Bepridil; D000638:Amiodarone