Seizure freedom off antiepileptic drugs after temporal lobe epilepsy surgery.
Data are limited on seizure recurrence after antiepileptic drug (AED) discontinuation in operated seizure-free patients. We reviewed seizure outcome in patients who came off AEDs after being seizure-free for 2 years following temporal lobe surgery in our center. Thirty-nine (68%) of 57 patients who discontinued AED therapy remained seizure-free. They had a younger age at surgery than the group with seizure recurrence (p=0.01). Earlier surgery may be a favorable predictor for seizure freedom after AED discontinuation.
Al-Kaylani
Muhammad
M
Department of Neurology, Vanderbilt University Medical Center, 2311 Pierce Avenue, Nashville, TN 37232, USA.
Konrad
Peter
P
Lazenby
Barry
B
Blumenkopf
Bennett
B
Abou-Khalil
Bassel
B
D000328:Adult; D000367:Age Factors; D038481:Anterior Temporal Lobectomy; D000927:Anticonvulsants / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D004833:Epilepsy, Temporal Lobe / Q000188:drug therapy / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012008:Recurrence; D012074:Remission Induction; D016896:Treatment Outcome
D000927:Anticonvulsants