title: Genetics of recurrent early-onset major depression (GenRED): final genome scan report.
abstract: OBJECTIVE
  The authors carried out a genomewide linkage scan to identify chromosomal regions likely to contain genes that contribute to susceptibility to recurrent early-onset major depressive disorder, the form of the disorder with the greatest reported risk to relatives of index cases.
  
  
  METHODS
  Microsatellite DNA markers were studied in 656 families with two or more such cases (onset before age 31 in probands and age 41 in other relatives), including 1,494 informative "all possible" affected relative pairs (there were 894 independent affected sibling pairs). Analyses included a primary multipoint allele-sharing analysis (with ALLEGRO) and a secondary logistic regression analysis taking the sex of each relative pair into account (male-male, male-female, female-female).
  
  
  RESULTS
  Genomewide suggestive evidence for linkage was observed on chromosome 15q25-q26 (at 105.4 centimorgans [cM]). The authors previously reported genomewide significant linkage in this region in the first 297 families. In the secondary analysis, after empirical genomewide correction for multiple testing, suggestive linkage results were observed on chromosome 17p12 (28.0 cM, excess sharing in male-male and male-female pairs) and on chromosome 8p22-p21.3 (25.1 cM, excess sharing in male-male pairs).
  
  
  CONCLUSIONS
  These regions of chromosomes 15q, 17p, and 8p might contain genes that contribute to susceptibility to major depression and related disorders. Evidence for linkage has been reported independently in the same regions of chromosome 15q for major depression and of chromosome 8p for related personality traits.
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 701A Welch Rd., Suite 3325, Palo Alto, CA 94304-5797, USA.
authors.forename: Peter
authors.initials: P
authors.lastname: Holmans
authors.forename: Myrna M
authors.initials: MM
authors.lastname: Weissman
authors.forename: George S
authors.initials: GS
authors.lastname: Zubenko
authors.forename: William A
authors.initials: WA
authors.lastname: Scheftner
authors.forename: Raymond R
authors.initials: RR
authors.lastname: Crowe
authors.forename: J Raymond
authors.initials: JR
authors.lastname: Depaulo
authors.forename: James A
authors.initials: JA
authors.lastname: Knowles
authors.forename: Wendy N
authors.initials: WN
authors.lastname: Zubenko
authors.forename: Kathleen
authors.initials: K
authors.lastname: Murphy-Eberenz
authors.forename: Diana H
authors.initials: DH
authors.lastname: Marta
authors.forename: Sandra
authors.initials: S
authors.lastname: Boutelle
authors.forename: Melvin G
authors.initials: MG
authors.lastname: McInnis
authors.forename: Philip
authors.initials: P
authors.lastname: Adams
authors.forename: Madeline
authors.initials: M
authors.lastname: Gladis
authors.forename: Jo
authors.initials: J
authors.lastname: Steele
authors.forename: Erin B
authors.initials: EB
authors.lastname: Miller
authors.forename: James B
authors.initials: JB
authors.lastname: Potash
authors.forename: Dean F
authors.initials: DF
authors.lastname: Mackinnon
authors.forename: Douglas F
authors.initials: DF
authors.lastname: Levinson
mesh_terms: D000328:Adult; D017668:Age of Onset; D002874:Chromosome Mapping / Q000706:statistics & numerical data*; D002884:Chromosomes, Human, Pair 15 / Q000235:genetics; D002886:Chromosomes, Human, Pair 17 / Q000235:genetics; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics; D015897:Comorbidity; D004276:DNA, Satellite / Q000235:genetics; D003865:Major Depressive Disorder / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics*; D005192:Family Health; D005260:Female; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D010551:Personality / Q000235:genetics; D012008:Recurrence
chemical_list: D004276:DNA, Satellite; D005819:Genetic Markers