Matrices containing NaCMC and HPMC 2. Swelling and release mechanism study.
The aim of the present study is an investigation of the swelling behaviour of matrix systems containing a mixture of hydroxypropylmethylcellulose (HPMC) and sodium carboxymethylcellulose (NaCMC) with a model soluble drug to find the correlation between the morphological behaviour and the drug release performance. The swelling study was conducted on tablets containing only the drug and the two polymers mixture (MB) and on reference tablets containing each polymer and the same drug, at three different pHs. MB matrices show a similar swelling trend at pH 4.5 and 6.8, while they have different behaviour in acidic fluid. At pH 1 the gel layer formed by NaCMC is characterized by a rigid structure of a partially chemically crosslinked hydrogel while HPMC and MB matrices form a physical not crosslinked gel. At pH 4.5 and 6.8, all the systems show the typical morphological behaviour of a swellable matrix in which the macromolecular chains in the gel network are held together by weak bondings (physical gel). In these buffers, MB systems maintain a constant drug release rate coupling diffusion and erosion mechanism: the gel and infiltrated layers thicknesses are maintained constant and a zero-order release kinetics can be achieved.
Conti
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S
Department of Pharmaceutical Chemistry, Via Taramelli, 12, I-27100 Pavia, Italy. stefania.conti@unipv.it
Maggi
L
L
Segale
L
L
Ochoa Machiste
E
E
Conte
U
U
Grenier
P
P
Vergnault
G
G
D002021:Buffers; D002266:Carboxymethylcellulose Sodium / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations; D004110:Diltiazem / Q000737:chemistry; D004337:Drug Carriers; D020100:Hydrogels; D006863:Hydrogen-Ion Concentration; D065347:Hypromellose Derivatives; D007700:Kinetics; D008747:Methylcellulose / Q000031:analogs & derivatives* / Q000737:chemistry; D015394:Molecular Structure; D012995:Solubility; D013607:Tablets; D013678:Technology, Pharmaceutical; D014867:Water / Q000737:chemistry
D002021:Buffers; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D020100:Hydrogels; D013607:Tablets; D014867:Water; D065347:Hypromellose Derivatives; D008747:Methylcellulose; D004110:Diltiazem; D002266:Carboxymethylcellulose Sodium