title: Minor increase of endtidal CO2 during sevoflurane-induced malignant hyperthermia.
abstract: Malignant hyperthermia (MH) in a pediatric patient during sevoflurane anesthesia with only a minor rise of endtidal CO(2) is described. MH was considered because of increased rectal temperature. The outcome was favorable after the initiation of a few simple measures (increased minute ventilation, cessation of sevoflurane). As recommended by the regional MH Reference Center, dantrolene was not used. In vitro contracture tests were performed on muscle biopsies from both parents. A strong contracture in response to halothane confirmed the father's MH susceptibility, thereby according a high probability of an MH episode in his son.
authors.affiliation: Département d'Anesthésie-Réanimation Ouest, CHU Nice, Nice, France. monabonciu@yahoo.com
authors.forename: Monalisa
authors.initials: M
authors.lastname: Bonciu
authors.forename: Arnaud
authors.initials: A
authors.lastname: de la Chapelle
authors.forename: Henry
authors.initials: H
authors.lastname: Delpech
authors.forename: Thiery
authors.initials: T
authors.lastname: Depret
authors.forename: Reneé
authors.initials: R
authors.lastname: Krivosic-Horber
authors.forename: Marc Raucoules
authors.initials: MR
authors.lastname: Aimé
mesh_terms: D018685:Anesthetics, Inhalation / Q000009:adverse effects*; D018686:Anesthetics, Intravenous / Q000008:administration & dosage; D001706:Biopsy / Q000379:methods; D001831:Body Temperature / Q000187:drug effects; D002245:Carbon Dioxide / Q000032:analysis; D002648:Child; D002781:Cholesteatoma / Q000601:surgery; D003402:Creatine Kinase / Q000097:blood; D000077324:Crystalloid Solutions; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007552:Isotonic Solutions / Q000008:administration & dosage; D008297:Male; D008305:Malignant Hyperthermia / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy*; D008738:Methyl Ethers / Q000009:adverse effects*; D009119:Muscle Contraction / Q000187:drug effects; D009211:Myoglobin / Q000097:blood; D009924:Organ Culture Techniques; D010290:Parents; D010880:Piperidines / Q000008:administration & dosage; D052097:Quadriceps Muscle / Q000473:pathology; D000077208:Remifentanil; D012121:Respiration, Artificial / Q000379:methods*; D000077149:Sevoflurane; D014433:Tympanoplasty / Q000379:methods
chemical_list: D018685:Anesthetics, Inhalation; D018686:Anesthetics, Intravenous; D000077324:Crystalloid Solutions; D007552:Isotonic Solutions; D008738:Methyl Ethers; D009211:Myoglobin; D010880:Piperidines; D002245:Carbon Dioxide; D000077149:Sevoflurane; D003402:Creatine Kinase; D000077208:Remifentanil