title: Immediate tight sealing of skin incisions using an innovative temperature-controlled laser soldering device: in vivo study in porcine skin.
abstract: BACKGROUND
  A feedback temperature-controlled laser soldering system (TCLS) was used for bonding skin incisions on the backs of pigs. The study was aimed: 1) to characterize the optimal soldering parameters, and 2) to compare the immediate and long-term wound healing outcomes with other wound closure modalities.
  
  
  METHODS
  A TCLS was used to bond the approximated wound margins of skin incisions on porcine backs. The reparative outcomes were evaluated macroscopically, microscopically, and immunohistochemically.
  
  
  RESULTS
  The optimal soldering temperature was found to be 65 degrees C and the operating time was significantly shorter than with suturing. The immediate tight sealing of the wound by the TCLS contributed to rapid, high quality wound healing in comparison to Dermabond or Histoacryl cyanoacrylate glues or standard suturing.
  
  
  CONCLUSIONS
  TCLS of incisions in porcine skin has numerous advantages, including rapid procedure and high quality reparative outcomes, over the common standard wound closure procedures. Further studies with a variety of skin lesions are needed before advocating this technique for clinical use.
authors.affiliation: School of Physics and Astronomy, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. davidsi@post.tau.ac.il
authors.forename: David
authors.initials: D
authors.lastname: Simhon
authors.forename: Marisa
authors.initials: M
authors.lastname: Halpern
authors.forename: Tamar
authors.initials: T
authors.lastname: Brosh
authors.forename: Tamar
authors.initials: T
authors.lastname: Vasilyev
authors.forename: Avi
authors.initials: A
authors.lastname: Ravid
authors.forename: Tamar
authors.initials: T
authors.lastname: Tennenbaum
authors.forename: Zvi
authors.initials: Z
authors.lastname: Nevo
authors.forename: Abraham
authors.initials: A
authors.lastname: Katzir
mesh_terms: D000818:Animals; D062109:Dermatologic Surgical Procedures; D004195:Disease Models, Animal; D004867:Equipment Design; D017075:Laser Coagulation / Q000295:instrumentation*; D012867:Skin / Q000473:pathology; D013529:Surgical Wound Dehiscence / Q000473:pathology / Q000601:surgery*; D013552:Swine; D013696:Temperature; D016896:Treatment Outcome; D014945:Wound Healing