Stereoelectronic effects dictate mechanistic dichotomy between Cu(II)-catalyzed and enzyme-catalyzed reactions of malonic acid half thioesters.
Fortner
Kevin C
KC
Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA.
Shair
Matthew D
MD
D000447:Aldehydes / Q000737:chemistry; D002384:Catalysis; D002413:Cations, Divalent; D003300:Copper / Q000737:chemistry*; D004789:Enzyme Activation; D004952:Esters / Q000737:chemistry*; D007700:Kinetics; D008314:Malonates / Q000737:chemistry*; D008956:Models, Chemical; D013438:Sulfhydryl Compounds / Q000737:chemistry*
D000447:Aldehydes; D002413:Cations, Divalent; D004952:Esters; D008314:Malonates; D013438:Sulfhydryl Compounds; D003300:Copper; C030290:malonic acid