title: The neurological legacy of John Russell Reynolds (1828-1896).
abstract: Sir John Russell Reynolds was an eminent and highly influential physician in the Victorian era who held the Presidencies of the Royal College of Physicians of London, and of the British Medical Association. He was the protégée of the great experimental physiologist, Marshall Hall, who discovered the reflex arc, and succeeded to Hall's clinical practice in London. Reynolds' thought and clinical activities linked the emerging British neurology of the first half of the 19th century with its blossoming, particularly in London, from 1860 onwards. In his writings Reynolds was the first English author to apply the approach to classification of neurological disorders that is still often used, though now in modified form. He was also the first to enunciate the notion of positive and negative symptoms arising from neurological disease and to suggest their pathogenesis, and was arguably the originator of the influential concept that an idiopathic disease, epilepsy, existed, one to be distinguished from 'epileptiform' seizures due to brain pathology.
authors.affiliation: Central Clinical School, University of Queensland, Royal Brisbane Hospital, Brisbane, Herston, 4029, Queensland, Australia. M.Eadie@uq.edu.au
authors.forename: M J
authors.initials: MJ
authors.lastname: Eadie
mesh_terms: D004827:Epilepsy / Q000266:history* / Q000503:physiopathology; D049672:History, 19th Century; D006801:Humans; D009462:Neurology / Q000266:history*