Precise excision and self-integration of a composite transposon as a model for spontaneous large-scale chromosome inversion/deletion of the Staphylococcus haemolyticus clinical strain JCSC1435.
Large-scale chromosomal inversions (455 to 535 kbp) or deletions (266 to 320 kbp) were found to accompany spontaneous loss of beta-lactam resistance during drug-free passage of the multiresistant Staphylococcus haemolyticus clinical strain JCSC1435. Identification and sequencing of the rearranged chromosomal loci revealed that ISSha1 of S. haemolyticus is responsible for the chromosome rearrangements.
Watanabe
Shinya
S
Department of Infection Control Science, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo, Japan.
Ito
Teruyo
T
Morimoto
Yuh
Y
Takeuchi
Fumihiko
F
Hiramatsu
Keiichi
K
D015296:Ceftizoxime / Q000494:pharmacology; D007446:Chromosome Inversion; D002876:Chromosomes, Bacterial / Q000235:genetics*; D004251:DNA Transposable Elements; D015321:Gene Rearrangement; D016680:Genome, Bacterial; D008957:Models, Genetic; D017384:Sequence Deletion; D041162:Staphylococcus haemolyticus / Q000187:drug effects / Q000235:genetics* / Q000302:isolation & purification / Q000472:pathogenicity
D004251:DNA Transposable Elements; D015296:Ceftizoxime