Effect of estrogen therapy on insulin resistance and plasminogen activator inhibitor type 1 concentrations in postmenopausal women.
OBJECTIVE
An elevated thrombotic risk due to abnormal fibrinolysis might be associated with insulin resistance in postmenopause. The aim of this study was to investigate the association of insulin resistance with a biochemical marker of fibrinolysis as well as the effect of transdermal estrogen treatment (ET) on this association.


METHODS
Thirty postmenopausal hysterectomized women received transdermal estradiol during 3 months. 17Beta-estradiol, FSH, LH, plasminogen activator inhibitor type 1 (PAI-1), insulin and glucose were measured in blood samples before and after ET. Insulin resistance was calculated by the use of the homeostasis model assessment for insulin resistance (HOMA-IR).


RESULTS
ET induced a significant decrement in both PAI-1 levels and HOMA-IR values. The study also showed that HOMA-IR was a significant predictor for PAI-1 concentrations.


CONCLUSIONS
Short-term ET improved HOMA-IR values in parallel with a decrease in PAI-1 levels.
Saucedo
Renata
R
Endocrine Research Unit, National Medical Center and Department of Hematology, Gabriel Mancera Hospital, Instituto Mexicano del Seguro Social, Hospital General de México, Mexico City, Mexico.
Basurto
Lourdes
L
Zarate
Arturo
A
Martínez
Carlos
C
Hernandez
Marcelino
M
Galván
Rosa
R
D000279:Administration, Cutaneous; D001786:Blood Glucose / Q000378:metabolism; D004958:Estradiol / Q000008:administration & dosage* / Q000097:blood*; D015914:Estrogen Replacement Therapy; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007328:Insulin / Q000097:blood*; D007333:Insulin Resistance; D007986:Luteinizing Hormone / Q000097:blood; D008875:Middle Aged; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood*; D017698:Postmenopause / Q000097:blood / Q000378:metabolism; D016387:Women's Health
D001786:Blood Glucose; D007328:Insulin; D017395:Plasminogen Activator Inhibitor 1; D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone