Autophagy in MHC class II presentation: sampling from within.
MHC class II molecules usually present exogenous antigens, but peptidome analyses have also identified many antigens from cytosolic or nuclear sources. In this issue of Immunity, Schmid et al. show that MHC class II molecules can present these through autophagosomes.
Menéndez-Benito
Victoria
V
Division of Tumor Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.
Neefjes
Jacques
J
D000818:Animals; D017951:Antigen Presentation / Q000276:immunology*; D001343:Autophagy / Q000276:immunology*; D000949:Histocompatibility Antigens Class II / Q000276:immunology*; D006801:Humans; D010588:Phagosomes / Q000276:immunology
D000949:Histocompatibility Antigens Class II