Treatment of McLeod phenotype chronic granulomatous disease with reduced-intensity conditioning and unrelated-donor umbilical cord blood transplantation.
Patients with chronic granulomatous disease (CGD) complicated by antimycotics-refractory invasive aspergillosis have an extremely poor prognosis if they cannot undergo allogeneic hematopoietic stem cell transplantation from a suitable related donor while in good clinical condition. We successfully treated a 20-year-old man with very rare McLeod phenotype CGD with reduced-intensity conditioning and unrelated-donor umbilical cord blood transplantation. We postulate that reduced-intensity conditioning-allogeneic hematopoietic stem cell transplantation is a promising therapeutic strategy for patients with CGD even if only unrelated-donor umbilical cord blood is available.
Suzuki
Nobuhiro
N
Department of Pediatrics, Sapporo Medical University School of Medicine, Sapporo, Japan. nsuzuki@sapmed.ac.jp
Hatakeyama
Naoki
N
Yamamoto
Masaki
M
Mizue
Nobuo
N
Kuroiwa
Yuki
Y
Yoda
Minami
M
Takahashi
Junko
J
Tani
Yoshihiko
Y
Tsutsumi
Hiroyuki
H
D000328:Adult; D001228:Aspergillosis; D036101:Cord Blood Stem Cell Transplantation / Q000379:methods*; D006105:Granulomatous Disease, Chronic / Q000150:complications / Q000628:therapy*; D006801:Humans; D008297:Male; D010641:Phenotype; D014019:Tissue Donors; D019172:Transplantation Conditioning / Q000379:methods*; D014184:Transplantation, Homologous; D016896:Treatment Outcome