title: Total intravenous anaesthesia with propofol or propofol/ketamine in spontaneously breathing dogs premedicated with medetomidine.
abstract: The cardiorespiratory parameters, the depth of anaesthesia and the quality of recovery were evaluated in six spontaneously breathing dogs that had been premedicated with medetomidine (40 microg/kg, supplemented with 20 microg/kg an hour later), administered with either propofol (1 mg/kg followed by 0.15 mg/kg/minute, intravenously), or with ketamine (1 mg/kg followed by 2 mg/kg/hour, intravenously) and propofol (0.5 mg/kg followed by 0.075 mg/kg/minute, intravenously). The dogs' heart rate and mean arterial blood pressure were higher and their minute volume of respiration and temperature were lower when they were anaesthetised with propofol plus ketamine, and a progressive hypercapnia leading to respiratory acidosis was more pronounced. When the dogs were anaesthetised with propofol/ketamine they recovered more quickly, but suffered some unwanted side effects. When the dogs were anaesthetised with propofol alone they recovered more slowly but uneventfully.
authors.affiliation: Clinic for Small Animal Medicine and Surgery, Veterinary Faculty, University of Ljubljana, Gerbiceva 60, 1000 Ljubljana, Slovenia.
authors.forename: A
authors.initials: A
authors.lastname: Seliskar
authors.forename: A
authors.initials: A
authors.lastname: Nemec
authors.forename: T
authors.initials: T
authors.lastname: Roskar
authors.forename: J
authors.initials: J
authors.lastname: Butinar
mesh_terms: D000762:Anesthesia Recovery Period; D000771:Anesthesia, Intravenous / Q000379:methods / Q000662:veterinary*; D019162:Anesthetics, Combined / Q000008:administration & dosage; D000778:Anesthetics, Dissociative / Q000008:administration & dosage; D018686:Anesthetics, Intravenous / Q000008:administration & dosage*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D018592:Cross-Over Studies; D004285:Dogs / Q000502:physiology*; D006339:Heart Rate / Q000187:drug effects; D006993:Hypnotics and Sedatives / Q000008:administration & dosage; D007649:Ketamine / Q000008:administration & dosage* / Q000009:adverse effects; D008297:Male; D020926:Medetomidine / Q000008:administration & dosage; D011229:Preanesthetic Medication / Q000662:veterinary; D015742:Propofol / Q000008:administration & dosage*; D012119:Respiration / Q000187:drug effects
chemical_list: D019162:Anesthetics, Combined; D000778:Anesthetics, Dissociative; D018686:Anesthetics, Intravenous; D006993:Hypnotics and Sedatives; D007649:Ketamine; D020926:Medetomidine; D015742:Propofol