title: Neurologic disease associated with 17D-204 yellow fever vaccination: a report of 15 cases.
abstract: Yellow fever (YF), can be prevented by an attenuated vaccine (YEL). We reviewed neurologic adverse events (AE) following YEL that were reported to the national Vaccine Adverse Events Reporting System (VAERS). VAERS is a passive reporting system with inherent limitations for causality assessment. Based on defined criteria, five cases of encephalitis were classified as 'definitely' and one of acute disseminated encephalomyelitis (ADEM) as 'probably' caused by YEL. Six cases of Guillain-Barre Syndrome (GBS), one of encephalitis, and two of ADEM, were classified as 'suspect' vaccine-associated disease. Laboratory and epidemiological evidence suggests that YEL caused encephalitis. Additional studies will be required to confirm whether YEL can rarely result in GBS and/or ADEM.
authors.affiliation: 1401 Rockville Pike, HFM-220, Rockville, MD 20852, USA. ann.mcmahon@fda.gov
authors.forename: Ann W
authors.initials: AW
authors.lastname: McMahon
authors.forename: Rachel B
authors.initials: RB
authors.lastname: Eidex
authors.forename: Anthony A
authors.initials: AA
authors.lastname: Marfin
authors.forename: Michelle
authors.initials: M
authors.lastname: Russell
authors.forename: James J
authors.initials: JJ
authors.lastname: Sejvar
authors.forename: Lewis
authors.initials: L
authors.lastname: Markoff
authors.forename: Edward B
authors.initials: EB
authors.lastname: Hayes
authors.forename: Robert T
authors.initials: RT
authors.lastname: Chen
authors.forename: Robert
authors.initials: R
authors.lastname: Ball
authors.forename: M Miles
authors.initials: MM
authors.lastname: Braun
authors.forename: Martin
authors.initials: M
authors.lastname: Cetron
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D004673:Encephalomyelitis, Acute Disseminated / Q000209:etiology*; D005260:Female; D020275:Guillain-Barre Syndrome / Q000209:etiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D014481:United States; D014611:Vaccination; D022341:Yellow Fever Vaccine / Q000009:adverse effects*
chemical_list: D022341:Yellow Fever Vaccine