HIPK2: a versatile switchboard regulating the transcription machinery and cell death.
Homeodomain interacting protein kinase 2 (HIPK2) is an evolutionary conserved serine/threonine kinase that regulates gene expression by phosphorylation of transcription factors and accessory components of the transcription machinery. HIPK2 is activated in response to DNA-damaging agents or morphogenic signals and accordingly HIPK2-guided gene expression programs trigger differentiation and development or alternatively apoptosis. The kinase contributes to the regulation of remarkably diverse pathways such as p53 activation or Wnt signaling. Here we discuss recent findings from biochemical and functional experiments that allow a deeper understanding of the pleiotropic effects mediated by HIPK2.
Calzado
Marco A
MA
Institute of Biochemistry, Medical Faculty, Justus-Liebig-University, Giessen, Germany.
Renner
Florian
F
Roscic
Ana
A
Schmitz
M Lienhard
ML
D000818:Animals; D017209:Apoptosis / Q000235:genetics; D002352:Carrier Proteins / Q000502:physiology*; D016923:Cell Death / Q000235:genetics; D002454:Cell Differentiation / Q000235:genetics; D018507:Gene Expression Regulation, Developmental / Q000502:physiology; D006801:Humans; D017346:Protein Serine-Threonine Kinases / Q000502:physiology*; D014158:Transcription, Genetic / Q000502:physiology*
D002352:Carrier Proteins; C115114:HIPK2 protein, human; D017346:Protein Serine-Threonine Kinases