title: Differentiation between diverticulitis and colorectal cancer: quantitative CT perfusion measurements versus morphologic criteria--initial experience.
abstract: OBJECTIVE
  To determine whether computed tomographic (CT) perfusion measurements in prospectively recruited patients can be used to differentiate between diverticulitis and colorectal cancer and to compare this discrimination with that of standard morphologic criteria.
  
  
  METHODS
  After institutional review board approval and written informed consent were obtained, 60 patients (24 men, 36 women; mean age, 69 years; range, 33.5-90.4 years; 20 patients with cancer, 20 with diverticulitis, and 20 with inactive diverticular disease) underwent CT perfusion imaging at the level of the colonic abnormality, and perfusion parameters were calculated. Analysis of variance was used to investigate any differences in perfusion between the patient groups. Two independent observers also analyzed an abdominopelvic CT study obtained immediately after the CT perfusion study and noted standard morphologic criteria for differential diagnosis. The sensitivity and specificity of CT perfusion measurements for determining the diagnostic category were compared with morphologic criteria by means of multivariate analysis to identify the most discriminatory criteria.
  
  
  RESULTS
  Mean blood volume, blood flow, transit time, and permeability were significantly different between patients with cancer and those with diverticulitis (P < .0001); patients with cancer had the highest blood volume, blood flow, and permeability and the shortest transit time. The most discriminatory criteria for determining diagnostic category were blood volume, transit time, permeability, and presence of pericolonic nodes (P = .05, .02, .04, and .02, respectively). Blood volume and blood flow each had a sensitivity of 80% and had specificity of 70% and 75%, respectively, for cancer in comparison with standard morphologic criteria: less than 5 cm of bowel involvement (45% sensitivity, 95% specificity), presence of a mass (85% sensitivity, 90% specificity), pericolonic inflammation (75% sensitivity, 5% specificity), and pericolonic nodes (90% sensitivity, 45% specificity).
  
  
  CONCLUSIONS
  CT perfusion measurements enable differentiation and better discrimination, in comparison with morphologic criteria, between cancer and diverticulitis.
authors.affiliation: Paul Strickland Scanner Centre, Mount Vernon Hospital, Northwood, England.
authors.forename: Vicky
authors.initials: V
authors.lastname: Goh
authors.forename: Steve
authors.initials: S
authors.lastname: Halligan
authors.forename: Stuart A
authors.initials: SA
authors.lastname: Taylor
authors.forename: David
authors.initials: D
authors.lastname: Burling
authors.forename: Paul
authors.initials: P
authors.lastname: Bassett
authors.forename: Clive I
authors.initials: CI
authors.lastname: Bartram
mesh_terms: D000230:Adenocarcinoma / Q000000981:diagnostic imaging* / Q000473:pathology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001810:Blood Volume / Q000502:physiology; D002933:Cineradiography; D003287:Contrast Media / Q000008:administration & dosage; D003937:Diagnosis, Differential; D003974:Diatrizoate Meglumine / Q000008:administration & dosage; D004239:Diverticulitis, Colonic / Q000000981:diagnostic imaging* / Q000473:pathology; D005260:Female; D005772:Gastrointestinal Transit / Q000502:physiology; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D007408:Intestinal Absorption / Q000502:physiology; D007479:Iopamidol / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012039:Regional Blood Flow / Q000502:physiology; D012680:Sensitivity and Specificity; D012810:Sigmoid Diseases / Q000000981:diagnostic imaging* / Q000473:pathology; D012811:Sigmoid Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D003287:Contrast Media; D003974:Diatrizoate Meglumine; D007479:Iopamidol