title: The scientific basis for evaluation and management of thrombotic disorders.
abstract: The hemostatic mechanisms at work in the body involve a complex series of interactions between platelets, the endothelium, and the coagulation cascade. Much has been learned regarding the molecular mechanisms governing these intricate processes. The hypercoagulable state involves a disruption of the normal homeostatic equilibrium. This state may be either inherent or acquired. The prevention of associated thromboembolic complications requires therapeutic anticoagulation. A broader understanding of the factors contributing to these prothrombotic tendencies and the subtleties involved in their management provides the surgeon with another weapon in the armamentarium to promote better and safer patient outcomes.
authors.affiliation: Department of Surgery, Duke University Medical Center, Duke University, Box 2622 MSRB, Research Drive, Durham, NC 27710, USA.
authors.forename: Vanessa A
authors.initials: VA
authors.lastname: Olcese
authors.forename: Michael
authors.initials: M
authors.lastname: Stirling
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Lawson
mesh_terms: D000925:Anticoagulants / Q000008:administration & dosage / Q000009:adverse effects; D006493:Heparin / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D019990:Perioperative Care; D011300:Preoperative Care; D013921:Thrombocytopenia / Q000139:chemically induced / Q000628:therapy; D019851:Thrombophilia / Q000150:complications / Q000209:etiology; D013927:Thrombosis / Q000209:etiology / Q000628:therapy*
chemical_list: D000925:Anticoagulants; D006493:Heparin