title: Precise excision and self-integration of a composite transposon as a model for spontaneous large-scale chromosome inversion/deletion of the Staphylococcus haemolyticus clinical strain JCSC1435.
abstract: Large-scale chromosomal inversions (455 to 535 kbp) or deletions (266 to 320 kbp) were found to accompany spontaneous loss of beta-lactam resistance during drug-free passage of the multiresistant Staphylococcus haemolyticus clinical strain JCSC1435. Identification and sequencing of the rearranged chromosomal loci revealed that ISSha1 of S. haemolyticus is responsible for the chromosome rearrangements.
authors.affiliation: Department of Infection Control Science, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo, Japan.
authors.forename: Shinya
authors.initials: S
authors.lastname: Watanabe
authors.forename: Teruyo
authors.initials: T
authors.lastname: Ito
authors.forename: Yuh
authors.initials: Y
authors.lastname: Morimoto
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Takeuchi
authors.forename: Keiichi
authors.initials: K
authors.lastname: Hiramatsu
mesh_terms: D015296:Ceftizoxime / Q000494:pharmacology; D007446:Chromosome Inversion; D002876:Chromosomes, Bacterial / Q000235:genetics*; D004251:DNA Transposable Elements; D015321:Gene Rearrangement; D016680:Genome, Bacterial; D008957:Models, Genetic; D017384:Sequence Deletion; D041162:Staphylococcus haemolyticus / Q000187:drug effects / Q000235:genetics* / Q000302:isolation & purification / Q000472:pathogenicity
chemical_list: D004251:DNA Transposable Elements; D015296:Ceftizoxime