title: Ischemic heart disease.
abstract: Because of changing demographics, increasing numbers of patients with IHD are presenting for noncardiac surgery, and the risks of perioperative morbidity and mortality are significant. The Lee Cardiac Risk Index is applicable in defining perioperative cardiac risk: however, ACC/AHA guidelines may not be applicable comprehensively. The role of biomarkers in risk stratification still needs to be defined. Structured management protocols that help assess, diagnose, and treat patients with IHD preoperatively are likely to help decrease postoperative morbidity and mortality, but clearly are not applicable to all patients. Augmented hemodynamic control with beta-blockers or alpha-2 agonists and modulating inflammation by statins can play an important role in improving outcomes in many patients with IHD; preoperative coronary revascularization may be of limited value. Intraoperative anesthetic management that minimizes hemodynamic perturbations is important; however, the choice of a particular technique typically is not critical. Of critical importance is the postoperative management of the patient. Postoperative myocardial injury should be identified, evaluated, and managed aggressively. Secondary stresses such as sepsis, extubation, and anemia, which can increase demand on the heart, should be treated or minimized. Clearly, optimal care of the patient with IHD entails closely coordinated assessment and management throughout the preoperative, intraoperative, and postoperative phases, if one is to optimize short- and long-term outcomes.
authors.affiliation: Department of Anesthesiology, Yale University School of Medicine, 333 Cedar Street, TMP-3, New Haven, CT 06520-8051, USA. shamsuddin.akhtar@yale.edu
authors.forename: Shamsuddin
authors.initials: S
authors.lastname: Akhtar
mesh_terms: D000465:Algorithms; D000572:American Heart Association / Q000458:organization & administration; D017408:Guidelines as Topic / Q000592:standards; D006801:Humans; D007431:Intraoperative Complications / Q000175:diagnosis / Q000517:prevention & control; D009203:Myocardial Infarction / Q000175:diagnosis / Q000503:physiopathology; D017202:Myocardial Ischemia / Q000175:diagnosis / Q000517:prevention & control / Q000628:therapy; D019990:Perioperative Care; D011183:Postoperative Complications / Q000175:diagnosis / Q000517:prevention & control; D018570:Risk Assessment / Q000145:classification / Q000379:methods; D013312:Stress, Physiological / Q000175:diagnosis / Q000517:prevention & control / Q000628:therapy; D014481:United States