title: Synthesis, characterization and DNA-binding studies on La(III) and Ce(III) complexes containing ligand of N-phenyl-2-pyridinecarboxamide.
abstract: La(III) and Ce(III) complexes containing ligand of N-phenyl-2-pyridinecarboxamide (HL) were synthesized and characterized by elemental analyses, conductivity measurement, IR spectra and thermal analysis. The general formulas of the complexes were [Ln(HL)(3)(H(2)O)(2)](NO(3))(3).2H(2)O [Ln=La(III), Ce(III)]. The results indicated that the oxygen of carbonyl and the nitrogen of pyridyl coordinated to Ln(III), and there were also two water molecules taking part in coordination. Ln(III) and HL formed 1:3 chelate complexes and the coordination number was eight. The interaction between the complexes and DNA was studied by means of UV-vis spectra, fluorescence spectra, SERS spectra and agarose gel electrophoresis. The results showed that complexes can bind to DNA. The binding ability decreased in following order: La(III) complex, Ce(III) complex, and HL. The interaction modes between DNA and the three compounds were found to be mainly intercalative.
authors.affiliation: College of Chemical and Life Science, Zhejiang Normal University, 321004 Jinhua, China.
authors.forename: Xin-Qian
authors.initials: XQ
authors.lastname: He
authors.forename: Qiu-Yue
authors.initials: QY
authors.lastname: Lin
authors.forename: Rui-Ding
authors.initials: RD
authors.lastname: Hu
authors.forename: Xiao-Hong
authors.initials: XH
authors.lastname: Lu
mesh_terms: D002244:Carbon / Q000737:chemistry; D002563:Cerium / Q000737:chemistry*; D002614:Chelating Agents / Q000737:chemistry; D004247:DNA / Q000737:chemistry*; D004553:Electric Conductivity; D007811:Lanthanum / Q000737:chemistry*; D008024:Ligands; D008956:Models, Chemical; D009539:Nicotinic Acids / Q000032:analysis / Q000737:chemistry*; D009584:Nitrogen / Q000737:chemistry; D011725:Pyridines / Q000737:chemistry*; D013050:Spectrometry, Fluorescence / Q000379:methods; D013055:Spectrophotometry, Infrared / Q000379:methods; D013056:Spectrophotometry, Ultraviolet / Q000379:methods; D013059:Spectrum Analysis, Raman / Q000379:methods
chemical_list: D002614:Chelating Agents; D008024:Ligands; C524553:N-phenyl-2-pyridinecarboxamide; D009539:Nicotinic Acids; D011725:Pyridines; D002563:Cerium; D007811:Lanthanum; D002244:Carbon; D004247:DNA; D009584:Nitrogen