title: Protein structure: evolutionary bridges to new folds.
abstract: The question of whether novel, structurally different protein folds might have arisen from existing ones is crucial to understanding protein evolution. Recent work on cysteine-rich domains in Hydra proteins illuminates how evolutionary transitions between dramatically different structures might occur.
authors.affiliation: UCLA Department of Chemistry and Biochemistry, 611 Charles Young Drive East, Los Angeles, California 90095-1569, USA. yeates@mbi.ucla.edu
authors.forename: Todd O
authors.initials: TO
authors.lastname: Yeates
mesh_terms: D000818:Animals; D003545:Cysteine / Q000737:chemistry; D019143:Evolution, Molecular; D006829:Hydra / Q000737:chemistry*; D011487:Protein Conformation; D011506:Proteins / Q000737:chemistry*
chemical_list: D011506:Proteins; D003545:Cysteine