title: Unexpected altered specificity is responsible for St. Louis encephalitis virus recombinant protease autoproteolysis.
abstract: We report herein the study of the cleavage fragments generated by autoproteolysis of the St. Louis encephalitis virus recombinant protease. The cleavage sites leading to truncated forms were identified by microsequencing, which revealed an unexpected altered specificity of the recombinant proteinase towards unusual sequences.
authors.affiliation: Unité de virologie tropicale, Institut de médecine tropicale du service de santé des armées, BP 46, 13 998 Marseille armées, France. publi.viro@laposte.net
authors.forename: Boris A M
authors.initials: BA
authors.lastname: Pastorino
authors.forename: Christophe N
authors.initials: CN
authors.lastname: Peyrefitte
authors.forename: Marc
authors.initials: M
authors.lastname: Grandadam
authors.forename: Régine
authors.initials: R
authors.lastname: Lebrun
authors.forename: Danielle
authors.initials: D
authors.lastname: Moinier
authors.forename: Dominique
authors.initials: D
authors.lastname: Rolland
authors.forename: Hugues J
authors.initials: HJ
authors.lastname: Tolou
authors.forename: Maël
authors.initials: M
authors.lastname: Bessaud
mesh_terms: D000595:Amino Acid Sequence; D004665:Encephalitis Virus, St. Louis / Q000201:enzymology*; D010450:Endopeptidases / Q000378:metabolism*; D008969:Molecular Sequence Data; D011994:Recombinant Proteins / Q000378:metabolism*; D013379:Substrate Specificity
chemical_list: D011994:Recombinant Proteins; D010450:Endopeptidases