title: Morphological instability and cancer invasion: a 'splashing water drop' analogy.
abstract: BACKGROUND
  Tissue invasion, one of the hallmarks of cancer, is a major clinical problem. Recent studies suggest that the process of invasion is driven at least in part by a set of physical forces that may be susceptible to mathematical modelling which could have practical clinical value.
  We present an analogy between two unrelated instabilities. One is caused by the impact of a drop of water on a solid surface while the other concerns a tumor that develops invasive cellular branches into the surrounding host tissue. In spite of the apparent abstractness of the idea, it yields a very practical result, i.e. an index that predicts tumor invasion based on a few measurable parameters. We discuss its application in the context of experimental data and suggest potential clinical implications.
authors.affiliation: Dip. Neuroscience and CNISM, Università di Torino, Italy. caterina.guiot@unito.it
authors.forename: Caterina
authors.initials: C
authors.lastname: Guiot
authors.forename: Pier P
authors.initials: PP
authors.lastname: Delsanto
authors.forename: Thomas S
authors.initials: TS
authors.lastname: Deisboeck
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena; D002448:Cell Adhesion; D006801:Humans; D008433:Mathematics; D008954:Models, Biological; D009361:Neoplasm Invasiveness; D009369:Neoplasms / Q000473:pathology*; D013500:Surface Tension