title: DNA and RNA induced enantioselectivity in chemical synthesis.
abstract: One of the hallmarks of DNA and RNA structures is their elegant chirality. Using these chiral structures to induce enantioselectivity in chemical synthesis is as enticing as it is challenging. In recent years, three general approaches have been developed to achieve this, including chirality transfer by nucleotide templated synthesis, enantioselective catalysis by RNA/DNAzymes and DNA-based asymmetric catalysis. In this article the concepts behind these strategies as well as the important achievements in this field will be discussed.
authors.affiliation: Department of Organic Chemistry, Stratingh Institute, Nijenborgh 4, 9747 AG, Groningen, The Netherlands. J.G.Roelfes@rug.nl
authors.forename: Gerard
authors.initials: G
authors.lastname: Roelfes
mesh_terms: D002384:Catalysis; D004247:DNA / Q000138:chemical synthesis* / Q000737:chemistry; D008954:Models, Biological; D008958:Models, Molecular; D008968:Molecular Conformation; D009690:Nucleic Acid Conformation; D012313:RNA / Q000138:chemical synthesis* / Q000737:chemistry; D016337:RNA, Catalytic / Q000502:physiology
chemical_list: D016337:RNA, Catalytic; D012313:RNA; D004247:DNA