First identification of Pseudomonas aeruginosa isolates producing a KPC-type carbapenem-hydrolyzing beta-lactamase.
In Medellin, Colombia, three Pseudomonas aeruginosa isolates with high-level carbapenem resistance (MIC>or=256 microg/ml) and an isolate of Citrobacter freundii with reduced susceptibility to imipenem produced the plasmid-mediated class A carbapenemase KPC-2. This is the first report of a KPC-type beta-lactamase identified outside of the family Enterobacteriaceae.
Villegas
Maria Virginia
MV
CIDEIM, International Center for Medical Research and Training, Cali, Colombia.
Lolans
Karen
K
Correa
Adriana
A
Kattan
Juan Nicolas
JN
Lopez
Jaime A
JA
Quinn
John P
JP
D015780:Carbapenems / Q000378:metabolism / Q000494:pharmacology; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D006868:Hydrolysis; D008826:Microbial Sensitivity Tests; D011550:Pseudomonas aeruginosa / Q000201:enzymology* / Q000235:genetics; D001618:beta-Lactamases / Q000235:genetics / Q000378:metabolism*
D015780:Carbapenems; C434283:beta-lactamase KPC-1; D001618:beta-Lactamases