Predictors of recovery of ovarian function during weight gain in anorexia nervosa.
OBJECTIVE
To investigate whether serum levels of follicle-stimulating hormone (FSH), inhibin B, and anti-Müllerian hormone (AMH) can be used as predictors of recovery of ovarian function in anorexia nervosa after weight gain.


METHODS
Follow-up cohort study.


METHODS
Two specialized treatment centers for eating disorders, one for adolescents (aged between 12 and 17 years) and one for adults (older than the age of 17 years).


METHODS
Sixty-one young women (mean age, 18.2 years) with anorexia nervosa.


METHODS
None (standard treatment program).


METHODS
Time to recovery of menses.


RESULTS
Forty-two (69%) patients recovered in weight within the 1st year, of which only 24 (39%) reached resumption of regular menstrual cycles. Next to weight gain itself, initial ovarian endocrine markers such as FSH, inhibin B, and AMH hormone were capable of predicting chances for resumption of menses in a multivariate analysis with time to recovery as the main outcome measure.


CONCLUSIONS
Initial ovarian endocrine markers FSH, inhibin B, and AMH can predict successful recovery of ovarian function in anorexia nervosa patients undergoing treatment to gain weight.
van Elburg
Annemarie A
AA
Rudolf Magnus Institute of Neuroscience: Department of Child and Adolescent Psychiatry, University Medical Center, Utrecht, The Netherlands. a.van.elburg@altrecht.nl <a.van.elburg@altrecht.nl>
Eijkemans
Marinus J C
MJ
Kas
Martien J H
MJ
Themmen
Axel P N
AP
de Jong
Frank H
FH
van Engeland
Herman
H
Fauser
Bart C J M
BC
D000293:Adolescent; D000856:Anorexia Nervosa / Q000503:physiopathology* / Q000523:psychology / Q000628:therapy; D054304:Anti-Mullerian Hormone; D015992:Body Mass Index; D002648:Child; D015331:Cohort Studies; D004958:Estradiol / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006023:Glycoproteins / Q000097:blood; D006801:Humans; D007265:Inhibins / Q000097:blood; D010053:Ovary / Q000503:physiopathology*; D013735:Testicular Hormones / Q000097:blood; D015430:Weight Gain
D006023:Glycoproteins; D013735:Testicular Hormones; C422364:inhibin B; D004958:Estradiol; D007265:Inhibins; D054304:Anti-Mullerian Hormone; D005640:Follicle Stimulating Hormone