In(III)-mediated chemoselective dehydrogenative interaction of ClMe(2)SiH with carboxylic acids: direct chemo- and regioselective Friedel-Crafts acylation of aromatic ethers.
[reaction: see text] Chemoselective dehydrogenative interaction of ClMe(2)SiH with a carboxylic acid group in the presence of InX3 is reported. 13C NMR investigation revealed the formation of PhCOOSi(Cl)Me(2) as the major transient intermediate. Chemo- and regioselective Friedel-Crafts acylation of aromatic ethers directly from carboxylic acids was established.
Babu
Srinivasarao Arulananda
SA
Department of Applied Chemistry, Graduate School of Engineering, Osaka University, 2-1 Yamada-oka, Suita, Osaka 565-0871, Japan.
Yasuda
Makoto
M
Baba
Akio
A