Müllerian inhibiting substance and disrupted folliculogenesis in polycystic ovary syndrome.
OBJECTIVE
This study determines whether pretreatment levels of müllerian inhibiting substance/antimüllerian hormone (MIS/AMH) would reflect ovarian response to exogenous gonadotropin in women with polycystic ovary syndrome (PCOS) and ovulatory controls matched by age and weight.


METHODS
Case-control study of 20 women with PCOS and 10 normoovulatory women undergoing controlled ovarian hyperstimulation (COH) for in vitro fertilization (IVF) at an academic medical center.


RESULTS
Baseline serum MIS/AMH levels in PCOS were higher than those of normoovulatory women (P < .001). MIS/AMH levels increased after gonadotropin-releasing hormone (GnRH) agonist pituitary suppression; 0.5 ng/mL in PCOS (P = .12) and 0.7 ng/mL in controls (P < .02). In normoovulatory women, MIS/AMH at baseline, after pituitary suppression, and the interval change after pituitary suppression all correlated closely to the number of mature oocytes retrieved (P < .005). In PCOS, however, levels of MIS/AMH at baseline and after pituitary suppression did not show this correlation, whereas only the interval change correlated with the number of mature oocytes retrieved.


CONCLUSIONS
Baseline MIS/AMH is a good predictor of the ovarian response to COH in normoovulatory women but not in PCOS.
Wang
Jeff G
JG
Department of Obstetrics & Gynecology, Division of Reproductive Endocrinology, College of Physicians & Surgeons, Columbia University, New York, NY 10032, USA. jw781@columbia.edu
Nakhuda
Gary S
GS
Guarnaccia
Michael M
MM
Sauer
Mark V
MV
Lobo
Rogerio A
RA
D000328:Adult; D054304:Anti-Mullerian Hormone; D016022:Case-Control Studies; D005260:Female; D006023:Glycoproteins / Q000097:blood*; D006062:Gonadotropins / Q000494:pharmacology*; D006801:Humans; D006080:Ovarian Follicle / Q000502:physiology*; D011085:Polycystic Ovary Syndrome / Q000097:blood*; D012189:Retrospective Studies; D013735:Testicular Hormones / Q000097:blood*
D006023:Glycoproteins; D006062:Gonadotropins; D013735:Testicular Hormones; D054304:Anti-Mullerian Hormone