title: Anxiolytic effects of erythrinian alkaloids from Erythrina mulungu.
abstract: One new erythrinian alkaloid derivative, (+)-11alpha-hydroxyerythravine (1), and the known (+)-erythravine (2) and (+)-alpha-hydroxyerysotrine (3) were isolated from the flowers of Erythrina mulungu. Their structures were determined by spectroscopic/spectrometric data interpretation of 1H, 13C, and 2D NMR and MS experiments. The relative configuration was established by NOESY analysis, while the conformation adopted by these molecules was evaluated through molecular modeling studies and coupling constants obtained by NMR analysis. Furthermore, the anxiolytic effects of the E. mulungu aqueous alcoholic crude extract and of the purified alkaloids were evaluated using the elevated T-maze test.
authors.affiliation: Department of Psychobiology, FFCLRP, University of São Paulo, Avenida Bandeirantes, 3900, 14040-901 Ribeirão Preto, SP, Brazil.
authors.forename: Otavio
authors.initials: O
authors.lastname: Flausino
authors.forename: Luciana de Avila
authors.initials: Lde A
authors.lastname: Santos
authors.forename: Hugo
authors.initials: H
authors.lastname: Verli
authors.forename: Ana Maria
authors.initials: AM
authors.lastname: Pereira
authors.forename: Vanderlan da Silva
authors.initials: Vda S
authors.lastname: Bolzani
authors.forename: Ricardo Luiz
authors.initials: RL
authors.lastname: Nunes-de-Souza
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D014151:Anti-Anxiety Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001938:Brazil; D004895:Erythrina / Q000737:chemistry*; D035264:Flowers / Q000737:chemistry; D006576:Heterocyclic Compounds, 4 or More Rings / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008297:Male; D051379:Mice; D019906:Nuclear Magnetic Resonance, Biomolecular; D010946:Plants, Medicinal / Q000737:chemistry*
chemical_list: C517703:(+)-11alpha-hydroxyerythravine; C517705:(+)-alpha-hydroxyerysotrine; C517704:(+)-erythravine; D000470:Alkaloids; D014151:Anti-Anxiety Agents; D006576:Heterocyclic Compounds, 4 or More Rings