title: Association of bovine respiratory disease with clinical status and acute phase proteins in calves.
abstract: Eighty-four calves with respiratory disease from 18 herds in different parts of Finland were chosen for a study evaluating the capacity of different respiratory pathogens to cause changes in different acute phase protein concentrations, white blood cell (WBC) count and clinical signs. The selected acute phase proteins were fibrinogen, haptoglobin, serum amyloid-A, lipopolysaccharide binding protein and alpha1-acid glycoprotein. From each calf, a paired blood sample was obtained for serological studies of bovine parainfluenza virus-3, bovine respiratory syncytial virus, bovine coronavirus, bovine adenovirus-3 and bovine adenovirus-7. Tracheobronchial lavage was performed to detect bacteria and mycoplasma. Isolation of Pasteurella multocida was associated with increased concentrations of all tested acute phase proteins. For other pathogens, no significant relationships were observed. No association was present between viral or bacterial findings and WBC count.
authors.affiliation: Finnish Food Safety Authority/Saarioisten Lihanjalostus Oy, P.O. Box 2, FIN-40351 Jyväskylä, Finland. sanna.nikunen@evira.fi
authors.forename: S
authors.initials: S
authors.lastname: Nikunen
authors.forename: H
authors.initials: H
authors.lastname: Härtel
authors.forename: T
authors.initials: T
authors.lastname: Orro
authors.forename: E
authors.initials: E
authors.lastname: Neuvonen
authors.forename: R
authors.initials: R
authors.lastname: Tanskanen
authors.forename: S-L
authors.initials: SL
authors.lastname: Kivelä
authors.forename: S
authors.initials: S
authors.lastname: Sankari
authors.forename: P
authors.initials: P
authors.lastname: Aho
authors.forename: S
authors.initials: S
authors.lastname: Pyörälä
authors.forename: H
authors.initials: H
authors.lastname: Saloniemi
authors.forename: T
authors.initials: T
authors.lastname: Soveri
mesh_terms: D000209:Acute-Phase Proteins / Q000378:metabolism*; D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000097:blood* / Q000382:microbiology / Q000821:virology; D005387:Finland; D007958:Leukocyte Count; D010326:Pasteurella Infections / Q000097:blood / Q000382:microbiology / Q000662:veterinary*; D016979:Pasteurella multocida / Q000302:isolation & purification; D012141:Respiratory Tract Infections / Q000097:blood / Q000382:microbiology / Q000662:veterinary* / Q000821:virology
chemical_list: D000209:Acute-Phase Proteins