title: Rational design and synthesis of novel nucleotide anti-Giardia agents.
abstract: Design and synthesis of a novel nucleotide anti-Giardia agent that is micromolar inhibitor of Giardia trophozoite growth in culture is described.
authors.affiliation: Center for Drug Design, Academic Health Center, University of Minnesota, Minneapolis, MN 55455, USA.
authors.forename: Dae-Hwan
authors.initials: DH
authors.lastname: Suk
authors.forename: Laurent
authors.initials: L
authors.lastname: Bonnac
authors.forename: Christine C
authors.initials: CC
authors.lastname: Dykstra
authors.forename: Krzysztof W
authors.initials: KW
authors.lastname: Pankiewicz
authors.forename: Steven E
authors.initials: SE
authors.lastname: Patterson
mesh_terms: D000116:Acetylgalactosamine / Q000737:chemistry; D000818:Animals; D000981:Antiprotozoal Agents / Q000494:pharmacology*; D002236:Carbohydrate Conformation; D002240:Carbohydrate Sequence; D002473:Cell Wall / Q000187:drug effects; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D015195:Drug Design; D005872:Giardia / Q000378:metabolism*; D006801:Humans; D008956:Models, Chemical; D008969:Molecular Sequence Data; D009711:Nucleotides / Q000737:chemistry*; D053058:Trophozoites; D014867:Water / Q000737:chemistry
chemical_list: D000981:Antiprotozoal Agents; D009711:Nucleotides; D014867:Water; D000116:Acetylgalactosamine