title: Successful coronary artery bypass grafting after concurrent chemoradiation therapy in a patient with non-small-cell lung cancer: case report and review of the literature.
abstract: Mediastinal irradiation has been a major component of the treatment of Hodgkin disease as well as breast and lung tumors. A potentially devastating posttreatment complication of mediastinal irradiation is the development of premature coronary artery disease. Coronary bypass grafting in such patients is difficult because of the presence of extensive radiation-induced mediastinal fibrosis. We present a rare case of patient with non-small-cell lung cancer who underwent successful coronary bypass grafting despite having previously received full-dose thoracic irradiation in conjunction with concurrent chemotherapy.
authors.affiliation: Drexel University College of Medicine, Philadelphia, PA 19102, USA. sibrahim@drexelmed.edu
authors.forename: Sulfi
authors.initials: S
authors.lastname: Ibrahim
authors.forename: Corey J
authors.initials: CJ
authors.lastname: Langer
mesh_terms: D000230:Adenocarcinoma / Q000628:therapy*; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001026:Coronary Artery Bypass; D003324:Coronary Artery Disease / Q000209:etiology* / Q000601:surgery; D006801:Humans; D008175:Lung Neoplasms / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D011832:Radiation Injuries / Q000601:surgery*; D011878:Radiotherapy / Q000009:adverse effects*; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents