Complete structure elucidation of shishididemniols, complex lipids with tyramine-derived tether and two serinol units, from a marine tunicate of the family Didemnidae.
Two new serinolipid derivatives, shishididemniols A (1) and B (2), were isolated as antibacterial constituents of a tunicate of the family Didemnidae. The structure of 1 was elucidated by interpretation of spectral data and the application of the modified Mosher method to 1 and its suitable degradation products. Compound 2 was the chlorohydrin of 1. Compounds 1 and 2 exhibited antibacterial activity against fish pathogenic bacterium Vibrio anguillarum.
Kobayashi
Hirotsugu
H
Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan.
Ohashi
Jun'ichiro
J
Fujita
Tsuyoshi
T
Iwashita
Takashi
T
Nakao
Yoichi
Y
Matsunaga
Shigeki
S
Fusetani
Nobuhiro
N
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D008055:Lipids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D015394:Molecular Structure; D014561:Urochordata / Q000737:chemistry*; D014733:Vibrio / Q000187:drug effects
D000900:Anti-Bacterial Agents; D008055:Lipids