Plasma homocysteine concentration in patients with poor or good coronary collaterals.
BACKGROUND
Elevated plasma homocysteine (Hcy) concentrations are associated with an increased risk of vascular disease. Hcy is known to inhibit endothelial cell proliferation in vitro. The purpose of the present study was to investigate the role of plasma Hcy concentrations on development of collateral circulation in single-vessel chronic total occlusion.


RESULTS
Collateral status was determined by Rentrop's classification. Of 817 patients, 56 cases of pure single-vessel chronic total occlusion were studied. Plasma Hcy concentrations in patients with single-vessel total coronary occlusion were higher compared with controls (17.3 +/-12.6 micromol/L vs 10.9+/-4.9 micromol/L, p=0.015). There was no significant difference in plasma Hcy concentrations of the good and poor collateral groups (17.2+/-13.7 micromol/L vs 15.3+/-9.3 micromol/L, p=0.834). Plasma Hcy concentrations in individual Rentrop subclasses 0, 1, 2 and 3 were as follows: 15.9 +/-9.1, 16.3+/-12.4, 17.1+/-14.1 and 20.1+/-13.5 micromol/L (p=0.893). There was a positive linear correlation between Rentrop subclass and angina pectoris duration (r=0.41, p=0.003). Angina pectoris duration was the only independent variable affecting the development of coronary collaterals in the present study (odds ratio [confidence interval]: 1.85 [1.12-2.91], p=0.014).


CONCLUSIONS
Patients with single-vessel chronic total occlusion had higher plasma Hcy concentrations than controls, but similar Hcy concentrations when compared according to the presence of poor or good coronary collaterals. There is a lack of association between plasma Hcy concentration and coronary collateral status in the current study.
Sayar
Nurten
N
Siyami Ersek Cardiovascular and Thoracic Surgery Research Hospital, Department of Cardiology, Istanbul, Turkey. sayarnurten@gmail.com
Terzi
Sait
S
Bilsel
Tuba
T
Yilmaz
Hale Yaka
HY
Orhan
Lutfullah
L
Cakmak
Nazmiye
N
Erdem
Ismail
I
Tangurek
Burak
B
Ciloglu
Figen
F
Peker
Ismail
I
Yesilcimen
Kemal
K
D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D002908:Chronic Disease; D003097:Collateral Circulation / Q000502:physiology*; D003327:Coronary Disease / Q000097:blood* / Q000503:physiopathology*; D005260:Female; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000097:blood / Q000503:physiopathology; D016017:Odds Ratio
D006710:Homocysteine