A checklist for medication compliance and persistence studies using retrospective databases.
The increasing number of retrospective database studies related to medication compliance and persistence (C&P), and the inherent variability within each, has created a need for improvement in the quality and consistency of medication C&P research. This article stems from the International Society of Pharmacoeconomics and Outcomes Research (ISPOR) efforts to develop a checklist of items that should be either included, or at least considered, when a retrospective database analysis of medication compliance or persistence is undertaken. This consensus document outlines a systematic approach to designing or reviewing retrospective database studies of medication C&P. Included in this article are discussions on data sources, measures of C&P, results reporting, and even conflict of interests. If followed, this checklist should improve the consistency and quality of C&P analyses, which in turn will help providers and payers understand the impact of C&P on health outcomes.
Peterson
Andrew M
AM
Department of Pharmacy Practice/Pharmacy Administration, Philadelphia College of Pharmacy, University of the Sciences in Philadelphia, 600 South 43rd Street, Philadelphia, PA 19104, USA. a.peters@usip.edu
Nau
David P
DP
Cramer
Joyce A
JA
Benner
Josh
J
Gwadry-Sridhar
Femida
F
Nichol
Michael
M
D016206:Databases, Bibliographic / Q000592:standards*; D004358:Drug Therapy; D017408:Guidelines as Topic; D006801:Humans; D007390:International Agencies; D010349:Patient Compliance; D012107:Research Design; D012189:Retrospective Studies; D012957:Societies, Pharmaceutical; D014481:United States