title: Synthesis and biological evaluation of new taxoids derived from 2-deacetoxytaxinine J.
abstract: A small library of 2-deacetoxytaxinine J (DAT-J) 1 derivatives was synthesised and tested in vitro for their reversal activity in human mammary carcinoma MDR cell line MCF7-R. One of the new taxoids showed to be active at 0.1 microM when tested in combination with paclitaxel.
authors.affiliation: Dipartimento Farmaco Chimico Tecnologico, Università degli Studi di Siena, via A. Moro, 53100 Siena, Italy. botta@unisi.it
authors.forename: Maurizio
authors.initials: M
authors.lastname: Botta
authors.forename: Silvia
authors.initials: S
authors.lastname: Armaroli
authors.forename: Daniele
authors.initials: D
authors.lastname: Castagnolo
authors.forename: Gabriele
authors.initials: G
authors.lastname: Fontana
authors.forename: Paula
authors.initials: P
authors.lastname: Pera
authors.forename: Ezio
authors.initials: E
authors.lastname: Bombardelli
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis* / Q000494:pharmacology*; D001943:Breast Neoplasms / Q000188:drug therapy / Q000473:pathology; D045744:Cell Line, Tumor; D019008:Drug Resistance, Neoplasm; D005260:Female; D019450:Genes, MDR / Q000235:genetics; D006801:Humans; D007202:Indicators and Reagents; D043823:Taxoids / Q000138:chemical synthesis* / Q000494:pharmacology*
chemical_list: C519723:2-deacetoxytaxinine J; D000972:Antineoplastic Agents, Phytogenic; D007202:Indicators and Reagents; D043823:Taxoids