title: Systemically disseminated extranodal marginal zone B-cell lymphoma of lacrimal gland in a patient with systemic lupus erythematosus.
abstract: A 33-year-old woman with systemic lupus erythematosus had bilateral eyelid swelling. On examination, bilateral lacrimal gland mass were palpable. The morphologic and the immunohistochemical features were supportive of the diagnosis of extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue-type (MALT lymphoma). Further systemic evaluation revealed she had clinical stage IV disease with bone marrow involvement. She underwent local radiotherapy and several cycles of chemotherapy. However, the patient died of sepsis with the disease after 48 months. Systemically disseminated MALT lymphoma presenting initially in the lacrimal gland of a patient with systemic lupus erythematosus is rare, and the prognosis is poor.
authors.affiliation: Department of Ophthalmology, Su-Ao Veterans Hospital, I-Lan, Taiwan, Republic of China.
authors.forename: Yen-Ching
authors.initials: YC
authors.lastname: Lin
authors.forename: Hui-Chuan
authors.initials: HC
authors.lastname: Kau
authors.forename: Shu-Ching
authors.initials: SC
authors.lastname: Kao
authors.forename: Wen-Ming
authors.initials: WM
authors.lastname: Hsu
authors.forename: Chieh-Chih
authors.initials: CC
authors.lastname: Tsai
mesh_terms: D000328:Adult; D019046:Bone Marrow Neoplasms / Q000473:pathology*; D005134:Eye Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007766:Lacrimal Apparatus Diseases / Q000000981:diagnostic imaging / Q000473:pathology*; D008180:Lupus Erythematosus, Systemic / Q000473:pathology*; D018442:Lymphoma, B-Cell, Marginal Zone / Q000000981:diagnostic imaging / Q000473:pathology*; D009367:Neoplasm Staging; D009915:Orbit / Q000000981:diagnostic imaging; D014057:Tomography, X-Ray Computed