title: Discovery of chemical reactions through multidimensional screening.
abstract: Multidimensional reaction screening of ortho-alkynyl benzaldehydes with a variety of catalysts and reaction partners was conducted in an effort to identify new chemical reactions. Reactions affording unique products were selected for investigation of preliminary scope and limitations.
authors.affiliation: Department of Chemistry and Center for Chemical Methodology and Library Development (CMLD-BU), Boston University, 590 Commonwealth Avenue, Boston, Massachusetts 02215, USA.
authors.forename: Aaron B
authors.initials: AB
authors.lastname: Beeler
authors.forename: Shun
authors.initials: S
authors.lastname: Su
authors.forename: Chris A
authors.initials: CA
authors.lastname: Singleton
authors.forename: John A
authors.initials: JA
authors.lastname: Porco
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D001547:Benzaldehydes / Q000737:chemistry*; D001688:Biological Products / Q000737:chemistry; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D008024:Ligands; D008956:Models, Chemical; D010636:Phenols / Q000737:chemistry
chemical_list: D000480:Alkynes; D001547:Benzaldehydes; D001688:Biological Products; D008024:Ligands; D010636:Phenols