title: [Endometrial evaluation in menopausal women after six months of isoflavones].
abstract: OBJECTIVE
  To evaluate the endometrium of menopausal women before and after six months use of total isoflavone.
  
  
  METHODS
  A non-controlled clinical, type "before and after" trial was carried out with 32 post-menopause women, between 40 and 60 years of age. They received 80 mg/day of total isoflavones obtained from Trifolium pratense (Climadilâ) during six months. They were evaluated at the beginning and end of treatment by transvaginal pelvic ecography, hysteroscopy and endometrial biopsy.
  
  
  METHODS
  Data collected were registered by means of the Epi info, version 6.04 b software, data analysis was made using the SAS version 8.2 statistics program, considering a significance level (alpha) of 0.05 and a 0.80 power (1-beta). In order to study the average variation of endometrial thickness and variation of the hysteroscopic and hystologic findings the t Student test for paired data was used.
  
  
  RESULTS
  Among the 32 participant women, six presented vaginal bleeding and three presented endometrial alteration when compared to the initial exams. Two of the women developed endometrial cell proliferation and one of them endometrial hyperplasia. There were no significant alterations in relation to endometrial thickness.
  
  
  CONCLUSIONS
  In this study, three women who used isoflavones during the six month period presented endometrial activity.
authors.affiliation: Universidade Estadual de Campinas e Universidade de Taubaté, São Paulo.
authors.forename: Luis Paulo Galvão
authors.initials: LP
authors.lastname: Wolff
authors.forename: Marcos Roberto
authors.initials: MR
authors.lastname: Martins
authors.forename: Aloísio José
authors.initials: AJ
authors.lastname: Bedone
authors.forename: Ilza Maria Urbano
authors.initials: IM
authors.lastname: Monteiro
mesh_terms: D000328:Adult; D001706:Biopsy; D004714:Endometrial Hyperplasia / Q000209:etiology; D004717:Endometrium / Q000187:drug effects* / Q000473:pathology*; D005260:Female; D019584:Hot Flashes; D006801:Humans; D006965:Hyperplasia; D015907:Hysteroscopy; D007529:Isoflavones / Q000009:adverse effects*; D008593:Menopause; D008875:Middle Aged; D011446:Prospective Studies; D013997:Time Factors; D014591:Uterine Diseases / Q000175:diagnosis / Q000209:etiology*; D014592:Uterine Hemorrhage / Q000209:etiology
chemical_list: D007529:Isoflavones