In vitro drug sensitivity-gene expression correlations involve a tissue of origin dependency.
A major concern of chemogenomics is to associate drug activity with biological variables. Several reports have clustered cell line drug activity profiles as well as drug activity-gene expression correlation profiles and noted that the resulting groupings differ but still reflect mechanism of action. The present paper shows that these discrepancies can be viewed as a weighting of drug-drug distances, the weights depending on which cell lines the two drugs differ in.
Andersson
C R
CR
The Linnaeus Center for Bioinformatics, Uppsala University, Uppsala, Sweden.
Fryknäs
M
M
Rickardson
L
L
Larsson
R
R
Isaksson
A
A
Gustafsson
M G
MG
D000818:Animals; D002460:Cell Line; D002477:Cells / Q000187:drug effects*; D016000:Cluster Analysis; D003196:Computer Graphics; D006801:Humans; D010597:Pharmacogenetics