Genetic control of immune response in carriers of ancestral haplotype 8.1: the study of chemotaxis.
In all caucasian populations the association of an impressive number of autoimmune diseases with genes from the HLA-B8, DR3 haplotype that is part of the ancestral haplotype (AH) 8.1 HLA-A1, Cw7, B8, TNFAB*a2b3, TNFN*S, C2*C, Bf*s, C4A*Q0, C4B*1, DRB1*0301, DRB3*0101, DQA1*0501, DQB1*0201 has been reported by different research groups. This haplotype, which is more common in northern Europe, is also associated with a number of immune system dysfunctions in healthy subjects. Analyzing the data according to gender, some dysfunctions are observed in women but not in men, in agreement with the role of X-linked genes and/or estrogens in the development and progression of autoimmune diseases. It has been proposed that a small number of genes within the 8.1 AH modify immune responsiveness and hence affect multiple immunopathological diseases. In this article, we demonstrate that neutrophil chemotaxis is significantly decreased in carriers of this AH, suggesting that this impairment may also be related to the increased occurrence of autoimmune diseases in these individuals.
Candore
Giuseppina
G
Gruppo di Studio sull'Immunosenescenza, Dipartimento di Biopatologia e Metodologie Biomediche, Corso Tukory 211, 90134 Palermo, Italy. gcandore@unipa.it
Balistreri
Carmela R
CR
Campagna
Anna Maria
AM
Colombo
Alfredo
A
Cuppari
Irene
I
Di-Carlo
Daniele
D
Grimaldi
Maria P
MP
Orlando
Valentina
V
Piazza
Giuseppina
G
Vasto
Sonya
S
Lio
Domenico
D
Caruso
Calogero
C
D000328:Adult; D002634:Chemotaxis, Leukocyte / Q000235:genetics*; D005260:Female; D015795:HLA-B8 Antigen / Q000235:genetics; D015803:HLA-DR3 Antigen / Q000235:genetics*; D006239:Haplotypes / Q000235:genetics*; D006579:Heterozygote; D006801:Humans; D007109:Immunity / Q000235:genetics; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000276:immunology*
D015795:HLA-B8 Antigen; D015803:HLA-DR3 Antigen