title: Preparation, characterization, and antioxidative effects of oligomeric proanthocyanidin-L-cysteine complexes.
abstract: Controlled acid-catalyzed degradation of proanthocyanidin polymers in grape seeds together with L-cysteine led to oligomeric proanthocyanidin-L-cysteine complexes along with monomeric flavan-3-ol derivatives being isolated, and their structures were confirmed on the basis of spectroscopic data and by chemical means. In addition, comparative studies on the antioxidative and survival effects of oligomeric proanthocyanidin-L-cysteine complexes and proanthocyanidin polymers were performed. The oligomeric proanthocyanidin-L-cysteine complexes showed higher bioavailability and antioxidant capacity and enhanced survival time in the animal test groups. In addition, it is suggested that the oligomeric complexes may help to prevent oxidative stress and may reduce free radical production.
authors.affiliation: Amino Up Chemical Company Ltd., High Tech Hill Shin-ei, 363-32 Kiyota, Sapporo 004-0839, Japan. hfujii@aminoup.co.jp
authors.forename: Hajime
authors.initials: H
authors.lastname: Fujii
authors.forename: Takashi
authors.initials: T
authors.lastname: Nakagawa
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nishioka
authors.forename: Eri
authors.initials: E
authors.lastname: Sato
authors.forename: Aya
authors.initials: A
authors.lastname: Hirose
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Ueno
authors.forename: Buxiang
authors.initials: B
authors.lastname: Sun
authors.forename: Takako
authors.initials: T
authors.lastname: Yokozawa
authors.forename: Gen-ichiro
authors.initials: G
authors.lastname: Nonaka
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D003545:Cysteine / Q000737:chemistry* / Q000494:pharmacology*; D005419:Flavonoids / Q000494:pharmacology; D008297:Male; D051379:Mice; D010636:Phenols / Q000494:pharmacology; D011108:Polymers / Q000737:chemistry* / Q000494:pharmacology; D059808:Polyphenols; D044945:Proanthocyanidins / Q000737:chemistry* / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000975:Antioxidants; D005419:Flavonoids; D010636:Phenols; D011108:Polymers; D059808:Polyphenols; D044945:Proanthocyanidins; D003545:Cysteine