title: Inherited corneal opacifications with an unusual distribution.
abstract: OBJECTIVE
  To describe corneal opacities of a new type and distribution in a small family.
  
  
  METHODS
  Family members were interviewed and examined to establish a pedigree and to detect any corneal abnormalities.
  
  
  RESULTS
  Two family members presented with corneal opacities. Both had, in the very peripheral cornea, flat, greyish, rounded opacities, 20-200 microm in diameter, on the Descemet's membrane. In addition, the mother had the same type of opacities over the central cornea just inside the Bowman's layer. The remaining parts of the corneas were clear. Vision was unaffected and the opacities caused no discomfort. There was no other corneal pathology. The subjects' general health was good.
  
  
  CONCLUSIONS
  To our knowledge, these types and distribution of corneal opacities have not been described previously. Although the mode of inheritance at this point is uncertain, we believe the changes are of a dystrophic nature.
authors.affiliation: Department of Ophthalmology, Linköping University Hospital, Linköping, Sweden. perfa@inr.liu.se
authors.forename: Per
authors.initials: P
authors.lastname: Fagerholm
authors.forename: Anette
authors.initials: A
authors.lastname: Dellby
authors.forename: Lennart
authors.initials: L
authors.lastname: Bäckman
mesh_terms: D000328:Adult; D003318:Corneal Opacity / Q000175:diagnosis / Q000235:genetics*; D003886:Descemet Membrane / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010375:Pedigree