title: [Liver transplantation for chronic liver disease: hospital costs].
abstract: OBJECTIVE
  Alcoholic cirrhosis and viral (especially hepatitis C) cirrhosis account for 50% of liver transplantation indications. The aim of our study was to evaluate the cost of liver transplantation from the hospital's perspective, according to indication.
  
  
  METHODS
  This retrospective study at a university hospital included 60 patients (cause of liver disease: alcoholic or hepatitis C-induced cirrhosis) who underwent liver transplantation between 1996 and 1999. All patients received the liver of brain-dead donors. The outcome measure was the cost of hospitalization from admission for transplantation through two years afterwards. The study does not include the costs of pre-transplantation evaluation or organ procurement. To calculate medical costs, we collected data about pharmaceutical use and laboratory tests for each patient. Logistic costs were calculated from French data for diagnosis-related groups, according to length of stay. Consultations and admissions in the two years after transplantation were collected, and their costs calculated.
  
  
  RESULTS
  Length of stay for transplantation (mean: 24 days, range 11-66) and costs (average 40 keuro per patient, range: 27.8-75.7, i.e., 52 keuro after escalation to 2006 levels) were similar. The cost of transplantation was higher (p=0.002) for Child C patients (mean: 46 keuro per patient, range: 31,1-72,8). Costs of follow-up after transplant (mean 5.4 keuro per patient, range: 0.87-19.7) varied, with consultation costs higher (p=0.002) in the alcoholic cirrhosis group (0.38 keuro versus 0.3 keuro) and hospitalization more expensive (p=0.0496) for the viral cirrhosis group (6 keuro versus 4,6 keuro).
  
  
  CONCLUSIONS
  We found that length of stay was the most important determinant of hospital costs for liver transplantation and that the indication for transplantation has a slight influence on resource utilization during the first two years after surgery.
authors.affiliation: Pharmacie, Hôpital Edouard Herriot, Lyon (69).
authors.forename: Carole
authors.initials: C
authors.lastname: Paillet
authors.forename: Valérie
authors.initials: V
authors.lastname: Chamouard
authors.forename: Alain
authors.initials: A
authors.lastname: Nageotte
authors.forename: Olivier
authors.initials: O
authors.lastname: Boillot
authors.forename: Cyrille
authors.initials: C
authors.lastname: Colin
authors.forename: Jérôme
authors.initials: J
authors.lastname: Dumortier
mesh_terms: D002908:Chronic Disease; D005602:France; D006760:Hospitalization / Q000191:economics*; D006801:Humans; D007902:Length of Stay; D008107:Liver Diseases / Q000191:economics / Q000601:surgery*; D016031:Liver Transplantation / Q000191:economics*; D008875:Middle Aged; D018579:Patient Selection