[Prolonged complete remission of multiple organ metastases after radical nephrectomy induced by interferon-alpha therapy: a case report].
We experienced a case of advanced renal carcinoma that showed complete remission to interferon-alpha therapy. A 76-year-old male underwent radical nephrectomy for left renal cell carcinoma (pT3b pN0 M0, stage III). Two and a half months later, chest X-ray, computed tomographic (CT) scan and ultrasonography revealed multiple lung metastases and a hepatic metastasis simultaneously. We started the intramuscular administration of natural interferon-alpha (OIF, 5 MIU) combined with cimetidine everyday. It caused leukopenia, a possible side-effect of interferon-alpha. We reduced the dose to three times a week. The lung metastases and hepatic metastases disappeared after 5 and 12 months, respectively. After we reduced the dose to once a week, there was no evidence of disease for 21 months.
Hirano
Atsushi
A
Department of Urology, Shakaihoken Chukyo Hospital.
Fujita
Takashi
T
Kimura
Toru
T
Katoh
Masashi
M
Tsuji
Yoshikazu
Y
Kinukawa
Tsuneo
T
Nojiri
Yoshikatsu
Y
D000368:Aged; D002292:Carcinoma, Renal Cell / Q000473:pathology / Q000628:therapy*; D006801:Humans; D016898:Interferon-alpha / Q000627:therapeutic use*; D007680:Kidney Neoplasms / Q000473:pathology / Q000628:therapy*; D008113:Liver Neoplasms / Q000188:drug therapy / Q000556:secondary*; D008175:Lung Neoplasms / Q000188:drug therapy / Q000556:secondary*; D008297:Male; D009392:Nephrectomy; D012074:Remission Induction / Q000379:methods
D016898:Interferon-alpha