title: Increasing incidence of club foot with higher population density: incidence and geographical variation in Denmark over a 16-year period--an epidemiological study of 936,525 births.
abstract: BACKGROUND
  The occurrence of club foot (CF) varies between countries and populations, and may be related to endogenous and exogenous factors. We analyzed the occurrence of CF in a whole country over a long period of time (16 years).
  
  
  METHODS
  Patients born in Denmark with a foot deformity 1978-93 were identified from the National Patient Register and the Register of Inborn Malformations. The records for each patient were studied in the hospital departments to establish the diagnoses and to obtain additional information. Demographic data were obtained from the Danish National Demographical Institute and from the Danish Population Register.
  
  
  RESULTS
  The incidence of isolated CF was 1.2/1,000 live births. It increased significantly during the study period, and the incidence of CF and the standardized morbidity ratio for CF were significantly positively correlated to population densities in the counties and the districts. There was no significant increase in the relative proportion of children with CF born to non-Scandinavian parents during the period.
  
  
  CONCLUSIONS
  The increasing incidence of isolated CF with higher population density indicates that there may be exogenous factors that are pathogenic.
authors.affiliation: Clinical Research Unit, Copenhagen University Hospital Hvidovre, Copenhagen, Denmark. mrk@dadlnet.dk
authors.forename: Michael R
authors.initials: MR
authors.lastname: Krogsgaard
authors.forename: Peder Klement
authors.initials: PK
authors.lastname: Jensen
authors.forename: Inge
authors.initials: I
authors.lastname: Kjaer
authors.forename: Henrik
authors.initials: H
authors.lastname: Husted
authors.forename: Jan
authors.initials: J
authors.lastname: Lorentzen
authors.forename: Berit
authors.initials: B
authors.lastname: Hvass-Christensen
authors.forename: Steen Bach
authors.initials: SB
authors.lastname: Christensen
authors.forename: Klaus
authors.initials: K
authors.lastname: Larsen
authors.forename: Stig
authors.initials: S
authors.lastname: Sonne-Holm
mesh_terms: D003025:Clubfoot / Q000453:epidemiology* / Q000208:ethnology; D003718:Denmark / Q000453:epidemiology / Q000208:ethnology; D005260:Female; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D008297:Male; D012042:Registries