Cognate chemokine receptor 1 messenger ribonucleic acid expression in peripheral blood as a diagnostic test for endometriosis.
We investigated the expression of the cognate chemokine receptor 1 (CCR1) messenger ribonucleic acid, a G-protein-coupled cognate chemokine receptor with high affinity for RANTES (Regulated upon Activation, Normal T cells Expressed and Secreted), in peripheral blood leukocytes of women with and without endometriosis, and its potential use as a diagnostic test for endometriosis. Because patients with an earlier diagnosis of this disease have a better treatment outcome and a reduced recurrence rate, CCR1 mRNA measurement in the peripheral blood of patients with suspected endometriosis might give us a new perspective in diagnosing and treating this disease earlier and better.
Agic
Admir
A
Xu
Hong
H
Rehbein
Mirka
M
Wolfler
Monika M
MM
Ebert
Andreas D
AD
Hornung
Daniela
D
D018394:CA-125 Antigen / Q000097:blood; D004715:Endometriosis / Q000097:blood / Q000175:diagnosis*; D005260:Female; D006801:Humans; D007962:Leukocytes / Q000378:metabolism*; D011247:Pregnancy; D012333:RNA, Messenger / Q000097:blood*; D054389:Receptors, CCR1; D019707:Receptors, Chemokine / Q000235:genetics*; D012680:Sensitivity and Specificity
D018394:CA-125 Antigen; C515300:CCR1 protein, human; D012333:RNA, Messenger; D054389:Receptors, CCR1; D019707:Receptors, Chemokine