[Adipokine and metabolic syndrome].
Adipose tissue is not simply a depot of energy, but is an active endocrine organ. The adipokines play an important role in the pathogenesis of metabolic syndrome. The proinflammatory adipokines secreted from expanded visceral adipose tissue directly induce insulin resistance and vascular injuries. A better understanding of the endocrine function of adipose tissue may lead to more rational therapy for metabolic syndrome.
Zhou
Li-bin
LB
Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrinology, Rui-Jin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China.
Chen
Ming-dao
MD
D052242:Adiponectin / Q000502:physiology*; D000273:Adipose Tissue / Q000503:physiopathology; D015195:Drug Design; D020738:Leptin / Q000502:physiology*; D024821:Metabolic Syndrome / Q000188:drug therapy / Q000503:physiopathology*; D052243:Resistin / Q000502:physiology*; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology
D052242:Adiponectin; D020738:Leptin; D052243:Resistin; D014409:Tumor Necrosis Factor-alpha