title: Fulminant amoebic colitis following loperamide use.
abstract: Toxic megacolon is a rare consequence of infection with Entamoeba histolytica. We present such a patient in whom the course of disease may have been influenced by heavy loperamide use. Loperamide and other anti-motility agents have been implicated previously in the pathogenesis of toxic megacolon in patients with infectious gastroenteritis.
authors.affiliation: Hospital for Tropical Diseases, University College London Hospitals NHS Trust, London, UK.
authors.forename: Alastair
authors.initials: A
authors.lastname: McGregor
authors.forename: Michael
authors.initials: M
authors.lastname: Brown
authors.forename: Khin
authors.initials: K
authors.lastname: Thway
authors.forename: Stephen G
authors.initials: SG
authors.lastname: Wright
mesh_terms: D000818:Animals; D000930:Antidiarrheals / Q000008:administration & dosage* / Q000009:adverse effects; D003082:Colectomy; D003937:Diagnosis, Differential; D003967:Diarrhea / Q000188:drug therapy* / Q000473:pathology; D004404:Dysentery, Amebic / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D004748:Entamoeba histolytica / Q000302:isolation & purification*; D005260:Female; D006801:Humans; D008139:Loperamide / Q000008:administration & dosage* / Q000009:adverse effects; D008875:Middle Aged; D012720:Severity of Illness Index; D014195:Travel
chemical_list: D000930:Antidiarrheals; D008139:Loperamide