title: In vitro drug sensitivity-gene expression correlations involve a tissue of origin dependency.
abstract: A major concern of chemogenomics is to associate drug activity with biological variables. Several reports have clustered cell line drug activity profiles as well as drug activity-gene expression correlation profiles and noted that the resulting groupings differ but still reflect mechanism of action. The present paper shows that these discrepancies can be viewed as a weighting of drug-drug distances, the weights depending on which cell lines the two drugs differ in.
authors.affiliation: The Linnaeus Center for Bioinformatics, Uppsala University, Uppsala, Sweden.
authors.forename: C R
authors.initials: CR
authors.lastname: Andersson
authors.forename: M
authors.initials: M
authors.lastname: Fryknäs
authors.forename: L
authors.initials: L
authors.lastname: Rickardson
authors.forename: R
authors.initials: R
authors.lastname: Larsson
authors.forename: A
authors.initials: A
authors.lastname: Isaksson
authors.forename: M G
authors.initials: MG
authors.lastname: Gustafsson
mesh_terms: D000818:Animals; D002460:Cell Line; D002477:Cells / Q000187:drug effects*; D016000:Cluster Analysis; D003196:Computer Graphics; D006801:Humans; D010597:Pharmacogenetics