title: Cholecystectomy versus no cholecystectomy in patients with silent gallstones.
abstract: BACKGROUND
  Cholecystectomy is currently advised only for patients with symptomatic gallstones. However, about 4% of patients with asymptomatic gallstones develop symptoms including cholecystitis, obstructive jaundice, pancreatitis, and gallbladder cancer.
  
  
  OBJECTIVE
  To assess the benefits and harms of surgical removal of the gallbladder for patients with asymptomatic gallstones.
  
  
  METHODS
  We searched The Cochrane Hepato-Biliary Group Controlled Trials Register, the Cochrane Central Register of Controlled Trials (CENTRAL) in The Cochrane Library, MEDLINE, EMBASE, and Science Citation Index Expanded until 2006 for identifying the randomised trials using The Cochrane Hepato-Biliary Group search strategy.
  
  
  METHODS
  Only randomised clinical trials (irrespective of language, blinding, or publication status) comparing cholecystectomy and no cholecystectomy were considered for the review.
  
  
  METHODS
  We were unable to identify any randomised clinical trials comparing cholecystectomy versus no cholecystectomy.
  
  
  RESULTS
  We were unable to identify any randomised clinical trial comparing cholecystectomy versus no cholecystectomy.
  
  
  CONCLUSIONS
  There are no randomised trials comparing cholecystectomy versus no cholecystectomy in patients with silent gallstones. Further evaluation of observational studies, which measure outcomes such as obstructive jaundice, gallstone-associated pancreatitis, and/or gall-bladder cancer for sufficient duration of follow-up is necessary before randomised trials are designed in order to evaluate whether cholecystectomy or no cholecystectomy is better for asymptomatic gallstones.
authors.affiliation: Royal Free Hospital, Surgery, 291 Greenhaven Drive, Thamesmead, London, UK, SE28 8FY. kurinchi2k@hotmail.com
authors.forename: K S
authors.initials: KS
authors.lastname: Gurusamy
authors.forename: K
authors.initials: K
authors.lastname: Samraj
mesh_terms: D002763:Cholecystectomy; D042882:Gallstones / Q000601:surgery*; D006801:Humans