title: Tuberculous meningitis in HIV-infected patients: drug susceptibility and clinical outcome.
abstract: The objective of this study was to identify prognostic factors of death in patients with tuberculous meningitis (TM) and show the impact of infection by multidrug-resistant strains on the outcome of this disease. We retrospectively analysed clinical charts of HIV-infected patients with culture-confirmed TM attending our institution during 1996-2004. The following variables were associated with death during hospitalization: neurological signs at admission, a CD4 T-cell count less than 50 cells/microl and infection by multidrug-resistant strains.
authors.affiliation: Infectious Diseases Division, Infectious Diseases Francisco Javier Muñiz Hospital, Buenos Aires, Argentina.
authors.forename: Diego
authors.initials: D
authors.lastname: Cecchini
authors.forename: Juan
authors.initials: J
authors.lastname: Ambrosioni
authors.forename: Clarisa
authors.initials: C
authors.lastname: Brezzo
authors.forename: Marcelo
authors.initials: M
authors.lastname: Corti
authors.forename: Ana
authors.initials: A
authors.lastname: Rybko
authors.forename: Marcela
authors.initials: M
authors.lastname: Perez
authors.forename: Susana
authors.initials: S
authors.lastname: Poggi
authors.forename: Marta
authors.initials: M
authors.lastname: Ambroggi
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy* / Q000276:immunology / Q000382:microbiology; D000328:Adult; D000995:Antitubercular Agents / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D011379:Prognosis; D012189:Retrospective Studies; D016896:Treatment Outcome; D014390:Tuberculosis, Meningeal / Q000188:drug therapy* / Q000276:immunology / Q000382:microbiology; D018088:Tuberculosis, Multidrug-Resistant / Q000188:drug therapy* / Q000276:immunology / Q000382:microbiology
chemical_list: D000995:Antitubercular Agents