Asymmetric total synthesis of martinelline and martinellic acid.
Herein, we describe the first asymmetric total synthesis of (-)-martinelline ((-)-2) and the second total synthesis of (-)-martinellic acid ((-)-1) by employing a tandem Mukaiyama-Mannich reaction/aminal cyclization as the key step.
Ikeda
Shuhei
S
Department of Organic Chemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, Aobayama, Sendai 980-8578, Japan.
Shibuya
Masatoshi
M
Iwabuchi
Yoshiharu
Y
D000470:Alkaloids / Q000138:chemical synthesis*; D002625:Chemistry, Organic / Q000379:methods*; D003500:Cyclization; D011758:Pyrroles / Q000138:chemical synthesis*; D011804:Quinolines / Q000138:chemical synthesis*
D000470:Alkaloids; D011758:Pyrroles; D011804:Quinolines; C432345:martinellic acid; C410408:martinelline