Effects of plasma nitric oxide levels on platelet activation in single donor apheresis and random donor concentrates.
P-selectin is an useful marker to determine platelet activation and nitric oxide inhibits platelet activation, secretion, adhesion and aggregation. The aim of this study was to investigate the relationship between nitric oxide and P-selectin values in both single donor apheresis and random donor platelet concentrates. According to the results of this study, we found that the best platelet concentrate is freshly prepared single donor apheresis concentrate and it is important to prevent activation at the beginning of the donation. Nitric oxide, which is synthesized from platelets during the storage period, is not sufficient to prevent platelet activation.
Büyükkağnici
Demet Iren
DI
Department of Pathophysiology, School of Medicine, Ankara University, Sihhiye, Ankara 06100, Turkey. demet.iren@mynet.com
Ilhan
Osman
O
Kavas
Güzin Ozelçi
GO
Arslan
Onder
O
Arat
Mutlu
M
Dalva
Klara
K
Ayyildiz
Erol
E
D001792:Blood Platelets / Q000166:cytology / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D009569:Nitric Oxide / Q000032:analysis / Q000096:biosynthesis*; D010949:Plasma / Q000737:chemistry / Q000378:metabolism; D015539:Platelet Activation; D010983:Plateletpheresis / Q000009:adverse effects; D011309:Preservation, Biological / Q000009:adverse effects; D011897:Random Allocation; D013997:Time Factors
D009569:Nitric Oxide