title: Long-term outcome of children born after a first-trimester measurement of nuchal translucency at the 99th percentile or greater with normal karyotype: a prospective study.
abstract: OBJECTIVE
  This study was undertaken to assess the long-term outcome of children born after a first-trimester measurement of nuchal translucency (NT) at the 99th percentile or greater during routine first-trimester screening in an unselected population.
  
  
  METHODS
  One hundred sixty-two infants were born alive. Clinical examination as well as a questionnaire to the parents (Ages and Stages Questionnaires [ASQ]) at the age of 2 years were obtained in 160 children. Our study population was compared with an external control group made of the 370 term control children.
  
  
  RESULTS
  The prevalence of abnormal clinical pediatric examination and ASQ results at 2 years were not associated with NT thickness. Comparison with an external control group did not demonstrate an increased incidence of developmental delay.
  
  
  CONCLUSIONS
  Parents should be informed that when the fetus is shown to be normal by ultrasound at 22-24 weeks of gestation the risk of adverse neonatal outcome or developmental delay in early childhood is not increased.
authors.affiliation: Department of Obstetrics and Gynecology, CHI Poissy-Saint Germain, Paris-Ile-de-France-Ouest Medical School, Paris, France.
authors.forename: Marie-Victoire
authors.initials: MV
authors.lastname: Senat
authors.forename: Laurence
authors.initials: L
authors.lastname: Bussières
authors.forename: Sophie
authors.initials: S
authors.lastname: Couderc
authors.forename: Joelle
authors.initials: J
authors.lastname: Roume
authors.forename: Patrick
authors.initials: P
authors.lastname: Rozenberg
authors.forename: Jean
authors.initials: J
authors.lastname: Bouyer
authors.forename: Yves
authors.initials: Y
authors.lastname: Ville
mesh_terms: D002675:Child, Preschool; D015331:Cohort Studies; D002658:Developmental Disabilities / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007621:Karyotyping; D048208:Nuchal Translucency Measurement; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011446:Prospective Studies; D011795:Surveys and Questionnaires; D013997:Time Factors