Efficient synthesis and biological evaluation of omega-oxygenated analogues of vitamin K2: study of modification and structure-activity relationship of vitamin K2 metabolites.
Novel omega-oxygenated vitamin K2 analogues, which are candidates for metabolites of vitamin K2 homologues, were efficiently synthesized and their apoptosis-inducing activity was evaluated. We revealed that some of those analogues were biologically active and the side-chain part played an important role in apoptosis-inducing activity. Our results can provide useful information to develop the structure-activity relationship of vitamin K2 analogues for new drugs based on vitamin K.
Suhara
Yoshitomo
Y
Department of Hygienic Sciences, Kobe Pharmaceutical University, 4-19-1 Motoyamakita-machi, Higashinada-ku, Kobe 658-8558, Japan.
Murakami
Aya
A
Kamao
Maya
M
Mimatsu
Shino
S
Nakagawa
Kimie
K
Tsugawa
Naoko
N
Okano
Toshio
T
D017209:Apoptosis / Q000187:drug effects; D045744:Cell Line, Tumor; D005434:Flow Cytometry; D018922:HL-60 Cells; D006801:Humans; D007202:Indicators and Reagents; D013329:Structure-Activity Relationship; D024482:Vitamin K 2 / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology*
D007202:Indicators and Reagents; D024482:Vitamin K 2