[Studies on the electron transfer between etoposide (VP-16) and DNA].
In the present study, the electron transfer between Etoposide (VP-16) and GMP or DNA was investigated using pulse radiolysis and circular dichroism technology. The electron transfer between VP-16 and GMP was found, and the reaction rate constant was determined as 3.16 x 10(7) L x mol(-1) x s(-1) by pulse radiolysis. The authors found the interaction of VP-16 and DNA using the technology of circular dichroism. This study has provided theoretical reference for further study on the anti-tumor mechanism of VP-16.
Zhang
Rui
R
School of Life Science and Technology, Tongji University, Shanghai 200092, China.
Shi
Jun
J
Wang
Shi-long
SL
Sun
Xiao-yu
XY
Zhang
Chao-jie
CJ
D002942:Circular Dichroism; D004247:DNA / Q000737:chemistry*; D004579:Electron Transport; D005047:Etoposide / Q000737:chemistry*; D011854:Radiochemistry
D005047:Etoposide; D004247:DNA