title: Cytotoxic constituents of the stems of Cinnamomum subavenium.
abstract: The aim of this study was to evaluate the cytotoxic effects of three new butanolides, subamolides A - C (1-3), and a new secobutanolide, secosubamolide (4), on the human colorectal cancer cell line SW480. Compounds 1-4 are new and were isolated from the stems of Cinnamomum subavenium, along with 17 known compounds. The structures of 1-4 were determined by spectroscopic analysis. Propidium iodide staining and flow cytometry were used to evaluate DNA damage of the treated SW480 cells, and it was found that 1-4 caused DNA damage in a dose-dependent manner after 24 h of treatment.
authors.affiliation: Basic Medical Science Education Center, Fooyin University, Kaohsiung County 831, Taiwan, Republic of China. xx377@ mail.fy.edu.tw
authors.forename: Chung-Yi
authors.initials: CY
authors.lastname: Chen
authors.forename: Ching-Hsein
authors.initials: CH
authors.lastname: Chen
authors.forename: Chung-Hang
authors.initials: CH
authors.lastname: Wong
authors.forename: Yi-Wen
authors.initials: YW
authors.lastname: Liu
authors.forename: Yu-Shan
authors.initials: YS
authors.lastname: Lin
authors.forename: Yau-Der
authors.initials: YD
authors.lastname: Wang
authors.forename: Yen-Ray
authors.initials: YR
authors.lastname: Hsui
mesh_terms: D015107:4-Butyrolactone / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D027424:Cinnamomum / Q000737:chemistry*; D004249:DNA Damage / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D015394:Molecular Structure; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; C517710:subamolide A; C517712:subamolide B; C517713:subamolide C; D015107:4-Butyrolactone