Wrestling rules in transrepression: as easy as SUMO-1, -2, -3?
A recent study in Molecular Cell uncovered parallel yet distinct SUMOylation pathways that provide insights into molecular mechanisms of transrepression mediated by activated nuclear receptors LXRalpha/beta and PPARgamma, thereby clarifying receptor, signal, and gene specificity of transrepression in inflammatory processes.
Treuter
Eckardt
E
Department of Biosciences and Nutrition, Karolinska Institutet, S-14157 Huddinge/Stockholm, Sweden. eckardt.treuter@biosci.ki.se
Gustafsson
Jan-Ake
JA
D000818:Animals; D015870:Gene Expression; D006801:Humans; D007249:Inflammation / Q000235:genetics / Q000378:metabolism; D051379:Mice; D008954:Models, Biological; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism; D015398:Signal Transduction; D025841:Small Ubiquitin-Related Modifier Proteins / Q000378:metabolism*
D018160:Receptors, Cytoplasmic and Nuclear; D025841:Small Ubiquitin-Related Modifier Proteins