Cardiac resurrection after bone-marrow-derived mononuclear cell transplantation during left ventricular assist device support.
We describe a novel therapy of mononuclear cell transplantation combined with a left ventricular assist device (LVAD) for severe ischemic heart failure. Significant myocardial recovery by the LVAD rarely occurs in the severely failing heart. We undertook successful mononuclear cell transplantation in a patient who sustained an acute myocardial infarction that had resulted in the LVAD therapy. The heart regained good function after cell transplantation, and the LVAD was explanted 6 weeks later. These results suggest that this novel therapy could be an alternative to cardiac transplantation for severe ischemic heart failure.
Gojo
Satoshi
S
Department of Cardiovascular Surgery, Saitama Medical Center, Saitama, Japan. satoshi@saitama-med.ac.jp
Kyo
Shunei
S
Nishimura
Shigeyuki
S
Komiyama
Nobuyuki
N
Kawai
Nobutaka
N
Bessho
Masami
M
Sato
Hiroshige
H
Asakura
Toshihisa
T
Nishimura
Motonobu
M
Ikebuchi
Kenji
K
D016026:Bone Marrow Transplantation; D002303:Cardiac Output, Low / Q000209:etiology / Q000503:physiopathology* / Q000601:surgery*; D006321:Heart / Q000503:physiopathology*; D006352:Heart Ventricles; D006353:Heart-Assist Devices; D006801:Humans; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000637:transplantation*; D011184:Postoperative Period; D020127:Recovery of Function; D012770:Shock, Cardiogenic / Q000150:complications*