title: Redefining risk in acute coronary syndromes using molecular medicine.
abstract: Acute coronary syndromes represent a complex phenotype involving the interplay of many elements. The risk of developing an acute coronary syndrome and related complications has been defined by variables such as age, diabetes, smoking history, serum creatine phosphokinase, or electrocardiographic findings. However, in the past 5 years the wide-scale acceptance of a protein--troponin--has changed the diagnostic profile. With advances in molecular medicine, this protein is a segue to a panel of molecular assays that will improve screening and tailored intervention. We expound upon some of these factors and the potential they may carry in changing clinical medicine.
authors.affiliation: Department of Cardiovascular Medicine, The Cleveland Clinic, Cleveland, Ohio, USA.
authors.forename: Saif
authors.initials: S
authors.lastname: Anwaruddin
authors.forename: Arman T
authors.initials: AT
authors.lastname: Askari
authors.forename: Eric J
authors.initials: EJ
authors.lastname: Topol
mesh_terms: D000789:Angina, Unstable / Q000175:diagnosis / Q000235:genetics / Q000628:therapy; D002097:C-Reactive Protein / Q000235:genetics / Q000378:metabolism; D023201:CD40 Ligand / Q000235:genetics / Q000378:metabolism; D005260:Female; D005819:Genetic Markers / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008967:Molecular Biology / Q000379:methods*; D009203:Myocardial Infarction / Q000175:diagnosis* / Q000235:genetics* / Q000628:therapy; D009204:Myocardial Revascularization / Q000379:methods; D019007:P-Selectin / Q000235:genetics / Q000378:metabolism; D011379:Prognosis; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D020107:Troponin T / Q000032:analysis / Q000235:genetics
chemical_list: D005819:Genetic Markers; D019007:P-Selectin; D020107:Troponin T; D023201:CD40 Ligand; D002097:C-Reactive Protein