title: Use of declarative statements in creating and maintaining computer-interpretable knowledge bases for guideline-based care.
abstract: Developing computer-interpretable clinical practice guidelines (CPGs) to provide decision support for guideline-based care is an extremely labor-intensive task. In the EON/ATHENA and SAGE projects, we formulated substantial portions of CPGs as computable statements that express declarative relationships between patient conditions and possible interventions. We developed query and expression languages that allow a decision-support system (DSS) to evaluate these statements in specific patient situations. A DSS can use these guideline statements in multiple ways, including: (1) as inputs for determining preferred alternatives in decision-making, and (2) as a way to provide targeted commentaries in the clinical information system. The use of these declarative statements significantly reduces the modeling expertise and effort required to create and maintain computer-interpretable knowledge bases for decision-support purpose. We discuss possible implications for sharing of such knowledge bases.
authors.affiliation: Stanford Medical Informatics, Stanford University, Stanford, CA, USA.
authors.forename: Samson W
authors.initials: SW
authors.lastname: Tu
authors.forename: Karen M
authors.initials: KM
authors.lastname: Hrabak
authors.forename: James R
authors.initials: JR
authors.lastname: Campbell
authors.forename: Julie
authors.initials: J
authors.lastname: Glasgow
authors.forename: Mark A
authors.initials: MA
authors.lastname: Nyman
authors.forename: Robert
authors.initials: R
authors.lastname: McClure
authors.forename: James
authors.initials: J
authors.lastname: McClay
authors.forename: Robert
authors.initials: R
authors.lastname: Abarbanel
authors.forename: James G
authors.initials: JG
authors.lastname: Mansfield
authors.forename: Susana M
authors.initials: SM
authors.lastname: Martins
authors.forename: Mary K
authors.initials: MK
authors.lastname: Goldstein
authors.forename: Mark A
authors.initials: MA
authors.lastname: Musen
mesh_terms: D020000:Decision Support Systems, Clinical; D004360:Drug Therapy, Computer-Assisted; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D051188:Knowledge Bases; D017410:Practice Guidelines as Topic; D012984:Software; D014584:User-Computer Interface