title: Stimulation of subthalamic fibre tracts reduces dyskinesias in STN-DBS.
abstract: Rarely, the postoperative management of patients with subthalamic deep brain stimulation (STN-DBS) is complicated by pharmacologically intractable dyskinesias. Here we report that in three of these patients additional stimulation of a proximal contact located within the subthalamic white matter may lead to a significant reduction of dyskinesias associated with STN-DBS. We propose that pallidofugal fiber tracts play a major role in the etiopathology of dyskinesias and their blockade through DBS may explain our observations.
authors.affiliation: Department of Neurology, Neurozentrum, Christian-Albrechts-Universität Kiel, Kiel, Germany.
authors.forename: J
authors.initials: J
authors.lastname: Herzog
authors.forename: M
authors.initials: M
authors.lastname: Pinsker
authors.forename: M
authors.initials: M
authors.lastname: Wasner
authors.forename: F
authors.initials: F
authors.lastname: Steigerwald
authors.forename: S
authors.initials: S
authors.lastname: Wailke
authors.forename: G
authors.initials: G
authors.lastname: Deuschl
authors.forename: J
authors.initials: J
authors.lastname: Volkmann
mesh_terms: D046690:Deep Brain Stimulation / Q000379:methods*; D020820:Dyskinesias / Q000503:physiopathology / Q000628:therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers / Q000502:physiology*; D009460:Neurologic Examination; D010300:Parkinson Disease / Q000503:physiopathology / Q000534:rehabilitation*; D011182:Postoperative Care / Q000379:methods; D011183:Postoperative Complications / Q000503:physiopathology / Q000628:therapy*; D020531:Subthalamic Nucleus / Q000503:physiopathology*