Highly regio- and stereoselective synthesis of indene derivatives via electrophilic cyclization.
[reaction: see text] Indene or naphthalene derivatives are readily prepared in moderate to excellent yields with high regio- and stereoselectivity under very mild reaction conditions by the reaction of acetylenic malonates and ketones with I2, ICl, or NIS. The resulting iodides can be further elaborated using palladium-catalyzed coupling reactions.
Bi
Hai-Peng
HP
State Key Laboratory of Applied Organic Chemistry, Lanzhou University, and State Key Laboratory of Solid Lubrication, Lanzhou Institute of Chemical Physics, Chinese Academy of Science, Lanzhou 730000, P.R. China.
Guo
Li-Na
LN
Duan
Xin-Hua
XH
Gou
Fa-Rong
FR
Huang
Shu-Hao
SH
Liu
Xue-Yuan
XY
Liang
Yong-Min
YM