Control of human immunodeficiency virus type 1 is associated with HLA-B*13 and targeting of multiple gag-specific CD8+ T-cell epitopes.
To better understand relationships between CD8+ T-cell specificity and the immune control of human immunodeficiency virus type 1 (HIV-1), we analyzed the role of HLA-B*13, an allele associated with low viremia, in a cohort of 578 C clade-infected individuals in Durban, South Africa. Six novel B*13-restricted cytotoxic T lymphocyte epitopes were defined from analyses of 37 B*13-positive subjects, including three Gag epitopes. These B*13-restricted epitopes contribute to a broad Gag-specific CD8+ response that is associated with the control of viremia. These data are consistent with data from studies of other HLA-class I alleles associated with HIV control that have shown that the targeting of multiple Gag epitopes is associated with relative suppression of viremia.
Honeyborne
Isobella
I
Department of Paediatrics, Peter Medawar Building for Pathogen Research, South Parks Road, Oxford OX1 3SY, United Kingdom.
Prendergast
Andrew
A
Pereyra
Florencia
F
Leslie
Alasdair
A
Crawford
Hayley
H
Payne
Rebecca
R
Reddy
Shabashini
S
Bishop
Karen
K
Moodley
Eshia
E
Nair
Kriebashnie
K
van der Stok
Mary
M
McCarthy
Noel
N
Rousseau
Christine M
CM
Addo
Marylyn
M
Mullins
James I
JI
Brander
Christian
C
Kiepiela
Photini
P
Walker
Bruce D
BD
Goulder
Philip J R
PJ
D000595:Amino Acid Sequence; D018414:CD8-Positive T-Lymphocytes / Q000737:chemistry / Q000276:immunology*; D018984:Epitopes, T-Lymphocyte / Q000276:immunology*; D015683:Gene Products, gag / Q000235:genetics / Q000276:immunology*; D015497:HIV-1 / Q000276:immunology*; D015235:HLA-B Antigens / Q000737:chemistry / Q000276:immunology*; D059908:HLA-B13 Antigen; D006801:Humans; D008969:Molecular Sequence Data; D009154:Mutation / Q000235:genetics
D018984:Epitopes, T-Lymphocyte; D015683:Gene Products, gag; D015235:HLA-B Antigens; D059908:HLA-B13 Antigen