The role of hyperthermia in combined treatment in the management of soft tissue sarcoma.
For high-risk soft tissue sarcomas (HR-STS) of adults, new treatment strategies are needed to improve outcome with regard to local control and overall survival. Systemic chemotherapy has been integrated either after (adjuvant) or before (neoadjuvant) optimal local treatment by surgery and radiotherapy in HR-STS. This short overview summarizes the results of the combination with regional hyperthermia as a new treatment strategy to open a new therapeutic window.
Issels
Rolf D
RD
University Hospital Medical Center Grosshadern Medical Clinic III, GSF-National Research Center for the Environment and Health, 81377 Munich, Germany. Rolf.Issels@med.uni-muenchen.de
Schlemmer
Marcus
M
Lindner
Lars H
LH
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D003131:Combined Modality Therapy; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D012509:Sarcoma / Q000188:drug therapy / Q000628:therapy*