title: Expression patterns of proliferating cell nuclear antigen in trichloroacetic acid peeled skin.
abstract: This study was designed to investigate whether trichloroacetic acid (TCA) peeling induces cellular proliferation in human skin using an immunohistochemical method. A 40% TCA peel resulted in a greater number of proliferating cell nuclear antigen (PCNA)-immunopositive cells in the whole epidermis as compared with 60% TCA or phenol peels. This finding suggests that long-term and frequent TCA peelings of low concentration would require special attention for unexpected cutaneous lesions such as skin tumors.
authors.affiliation: Department of Dermatology, Wakayama Medical University, Wakayama, Japan.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Yamamoto
authors.forename: Koji
authors.initials: K
authors.lastname: Uede
authors.forename: Nozomi
authors.initials: N
authors.lastname: Yonei
authors.forename: Fukumi
authors.initials: F
authors.lastname: Furukawa
mesh_terms: D049109:Cell Proliferation; D002615:Chemexfoliation / Q000009:adverse effects; D006801:Humans; D019800:Phenol; D018809:Proliferating Cell Nuclear Antigen / Q000032:analysis*; D012867:Skin / Q000166:cytology / Q000276:immunology*; D014238:Trichloroacetic Acid / Q000009:adverse effects
chemical_list: D018809:Proliferating Cell Nuclear Antigen; D019800:Phenol; D014238:Trichloroacetic Acid