Enhancing skin wound healing by direct delivery of intracellular adenosine triphosphate.
BACKGROUND
A new intracellular adenosine triphosphate (ATP) delivery technique has been developed and was tested for skin wound care.


METHODS
Eleven pairs of adult nude mice were used. ATP-vesicles were applied in 11 mice, and another 11 mice were treated with lipid vesicles only.


RESULTS
The group treated with ATP-encapsulated fusogenic small, unilamellar lipid vesicles healed faster than the group treated with only lipid vesicles. Histologic study indicated better developed granular tissue and re-epithelialization in the study group, and wound tissue vascular endothelial growth factor expressions were also higher in ATP-vesicles treated mice.


CONCLUSIONS
This intracellular ATP delivery system may provide a new hope for wound healing as well as the treatment of medical conditions in which ischemia is involved.
Chiang
Benjamin
B
Department of Surgery, University of Louisville, Louisville, KY 40202, USA.
Essick
Eric
E
Ehringer
William
W
Murphree
Sidney
S
Hauck
Mary Anne
MA
Li
Ming
M
Chien
Sufan
S
D000255:Adenosine Triphosphate / Q000494:pharmacology*; D043925:Angiogenesis Inducing Agents / Q000494:pharmacology*; D000818:Animals; D016503:Drug Delivery Systems; D004817:Epidermis / Q000187:drug effects; D006097:Granulation Tissue / Q000187:drug effects; D042541:Intracellular Space; D051379:Mice; D008819:Mice, Nude; D012867:Skin / Q000187:drug effects*; D053835:Unilamellar Liposomes; D042461:Vascular Endothelial Growth Factor A / Q000096:biosynthesis; D014945:Wound Healing / Q000187:drug effects*
D043925:Angiogenesis Inducing Agents; D053835:Unilamellar Liposomes; D042461:Vascular Endothelial Growth Factor A; D000255:Adenosine Triphosphate