title: Possible joint origin of restless leg syndrome (RLS) and migraine.
abstract: Sleep disorders have been described in migraine patients. Among sleep disorders RLS has been reported in up to one-third of migraineurs. Adverse effects of anti migraine therapy by dopamine antagonists can not fully explain this association. Therefore we present the hypothesis that RLS and migraine may have a joint origin. The hypothesis is supported by: (1) the same genetic origin for migraine without aura and RLS in single Italian family on chromosome 14q21; this gene codes survival motor neuron-interacting protein 1 (SIP1) which can play role in both diseases. (2) Correlation of both RLS and migraine with fibromyalgia. (3) Alteration of cortical excitability in both migraine and RLS.
authors.affiliation: Student Research Committee, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Behnam
authors.initials: B
authors.lastname: Sabayan
authors.forename: Mansooreh
authors.initials: M
authors.lastname: Bagheri
authors.forename: Afshin
authors.initials: A
authors.lastname: Borhani Haghighi
mesh_terms: D015897:Comorbidity; D018492:Dopamine Antagonists / Q000009:adverse effects*; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000235:genetics; D006801:Humans; D008881:Migraine Disorders / Q000453:epidemiology / Q000209:etiology* / Q000235:genetics*; D008954:Models, Biological; D012148:Restless Legs Syndrome / Q000453:epidemiology / Q000209:etiology* / Q000235:genetics*
chemical_list: D018492:Dopamine Antagonists