title: Decreased fractional urinary calcium excretion and serum 1,25-dihydroxyvitamin D and IGF-I levels in preeclampsia.
abstract: During preeclampsia several alterations of calcium metabolism have been described, the most common of them is hypocalciuria, which pathophysiology is still unclear. In order to assess the contribution of calciotropic hormones to urinary calcium excretion, a cross-sectional study was done including 26 preeclamptic Mexican women (PE group) and 26 normotensive control pregnant women (NT group). Total and fractional urinary calcium excretion were significantly lower (P<0.0001) in the PE group than in the NT group (82+/-7 versus 171+/-7 mg/24h and 0.62+/-0.38 versus 1.38+/-0.71%, respectively), without significant differences in creatinine clearance, urinary sodium excretion and phosphate tubular reabsorption. In addition, serum 1,25-(OH)(2)D and IGF-I levels were significantly (P<0.05) lower in the PE than in NT group (43+/-9 versus 50+/-9 pg/mL and 195+/-67 versus 293+/-105 ng/mL, respectively), without significant differences in serum PTH levels. In the NT group, association analysis showed that total and fractional urinary calcium excretions positively correlated with serum levels of 1,25-(OH)(2)D (P<0.01) and IGF-I (P<0.001). In the PE group, total urinary calcium excretion positively correlated only with serum 1,25-(OH)(2)D (P<0.05). In conclusion, the results obtained in this study confirm that PE is associated with hypocalciuria and suggest that 1,25-(OH)(2)D and/or IGF-I may be involved in the regulation of urinary calcium excretion.
authors.affiliation: Departamento de Biología de la Reproducción, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Vasco de Quiroga No 15, Col. Tlalpan, C.P. 14000, México D.F., Mexico. alih@quetzal.innsz.mx
authors.forename: Ali
authors.initials: A
authors.lastname: Halhali
authors.forename: Lorenza
authors.initials: L
authors.lastname: Díaz
authors.forename: Euclides
authors.initials: E
authors.lastname: Avila
authors.forename: Ana Carolina
authors.initials: AC
authors.lastname: Ariza
authors.forename: Michèle
authors.initials: M
authors.lastname: Garabédian
authors.forename: Fernando
authors.initials: F
authors.lastname: Larrea
mesh_terms: D000328:Adult; D002117:Calcitriol / Q000097:blood*; D002118:Calcium / Q000652:urine*; D005260:Female; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D011225:Pre-Eclampsia / Q000097:blood* / Q000652:urine*; D011247:Pregnancy
chemical_list: D007334:Insulin-Like Growth Factor I; D002117:Calcitriol; D002118:Calcium