title: Hemocompatibility of high strength oxide ceramic materials: an in vitro study.
abstract: High strength oxide ceramic materials like alumina and zirconia are frequently used for artificial joints because of their biocompatibility and high wear resistance. Their suitability as materials for implants and biomedical devices with direct blood contact, such as cardiovascular implants or components for blood pumps and dialyzers, has not been confirmed to date. The objective of this study was to investigate whether oxide ceramics show sufficient hemocompatibility. Dense specimens were made out of alumina, zirconia, titanium oxide, and aluminum titanate. Polyvinylchloride and silicone were additionally tested as reference materials. Interactions of human blood with the surfaces were studied by investigating partial thromboplastin time (PTT), thrombin antithrombin III complex (TAT), free plasma hemoglobin concentration, complete blood count, complement factor 5a, and protein adsorption. The results from the PTT and TAT tests clearly indicated higher blood activation by the ceramic materials when compared to the two polymer materials. However, alumina and zirconia showed lower C5a concentrations and less protein adsorption than the reference materials. Our results revealed that oxide ceramic materials alone cannot be used for implants in direct blood contact without modification of the ceramic surface, for example, by made-to-measure inert nanocoatings.
authors.affiliation: Department of Ceramics and Refractory Materials, RWTH Aachen University, Mauerstrasse 5, D-52064 Aachen, Germany. h.fischer@rwth-aachen.de
authors.forename: Horst
authors.initials: H
authors.lastname: Fischer
authors.forename: Maria
authors.initials: M
authors.lastname: Luk
authors.forename: Bernward
authors.initials: B
authors.lastname: Oedekoven
authors.forename: Rainer
authors.initials: R
authors.lastname: Telle
authors.forename: Khosrow
authors.initials: K
authors.lastname: Mottaghy
mesh_terms: D000042:Absorption; D000327:Adsorption; D000328:Adult; D000537:Aluminum Oxide / Q000737:chemistry*; D000990:Antithrombin III / Q000378:metabolism; D002516:Ceramics / Q000737:chemistry*; D015936:Complement C5a / Q000032:analysis; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D008422:Materials Testing / Q000379:methods*; D010314:Partial Thromboplastin Time; D016062:Porosity; D013917:Thrombin / Q000378:metabolism; D014867:Water; D015040:Zirconium / Q000737:chemistry*
chemical_list: D006454:Hemoglobins; D014867:Water; D015936:Complement C5a; D000990:Antithrombin III; D015040:Zirconium; D013917:Thrombin; D000537:Aluminum Oxide; C028541:zirconium oxide