Cardiac Glycosides from the Leaves of Digitalis cariensis.
From the leaves of DIGITALIS CARIENSIS in addition to the known glycosides, three new cardenolides, a major and two minor ones, have been isolated and their structures established as gluco-gitoxigenine-glucomethyloside (gitoxigenine-3- O-beta- D-glucosyl-beta- D-glucomethyloside), gitoxigenine-3- O-beta- D-glucosyl-beta- D-glucomethylosyl-beta- D-bisdigitoxoside, and gitoxigenine-3- O-beta- D-glucosyl-beta- D-glucomethylosyl-beta- D-digitoxide, respectively, by chemical evidence and FAB-MS. Except for the unstable glucolanadoxine, the known major components isolated from the leaves are glucogitoroside, glucoevatromonoside, digitalinum verum, gluco-digitoxigenine-glucomethyloside, glucodigifucoside, and glucogitofucoside. A total of 23 cardenolides present in the leaves in trace amounts were also identified.
Imre
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Faculty of Pharmacy, University of Istanbul, Beyazit-Istanbul, Turkey.
Yurdun
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