title: Microglial transplantation increases amyloid-beta clearance in Alzheimer model rats.
abstract: Immunization with amyloid-beta (Abeta) peptides, a therapeutic approach in Alzheimer's disease (AD), reduces brain Abeta, and microglial Abeta phagocytosis has been proposed as an Abeta-lowering mechanism. We transplanted rat microglia into the rat lateral ventricle just after intra-hippocampal Abeta injection, and then investigated the contribution of exogenous microglia to Abeta clearance. Migration of exogenous microglia from the lateral ventricle to Abeta plaque was detected by magnetic resonance imaging and histochemical analysis, and the clearance of Abeta was increased by transplantation. These results suggest the possible usefulness of exogenous microglia to the therapeutic approach in AD.
authors.affiliation: Department of Neurobiology and 21st Century COE Program, Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto 607-8414, Japan.
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Takata
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Kitamura
authors.forename: Daijiro
authors.initials: D
authors.lastname: Yanagisawa
authors.forename: Shigehiro
authors.initials: S
authors.lastname: Morikawa
authors.forename: Masahito
authors.initials: M
authors.lastname: Morita
authors.forename: Toshiro
authors.initials: T
authors.lastname: Inubushi
authors.forename: Daiju
authors.initials: D
authors.lastname: Tsuchiya
authors.forename: Saori
authors.initials: S
authors.lastname: Chishiro
authors.forename: Mana
authors.initials: M
authors.lastname: Saeki
authors.forename: Takashi
authors.initials: T
authors.lastname: Taniguchi
authors.forename: Shun
authors.initials: S
authors.lastname: Shimohama
authors.forename: Ikuo
authors.initials: I
authors.lastname: Tooyama
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism* / Q000473:pathology / Q000601:surgery*; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D000818:Animals; D016380:Brain Tissue Transplantation; D002465:Cell Movement; D004195:Disease Models, Animal; D006624:Hippocampus / Q000378:metabolism / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D017628:Microglia / Q000502:physiology / Q000637:transplantation*; D010587:Phagocytosis; D051381:Rats; D017208:Rats, Wistar; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D016229:Amyloid beta-Peptides; D014409:Tumor Necrosis Factor-alpha