title: Silicon nanotube array/gold electrode for direct electrochemistry of cytochrome c.
abstract: The highly ordered Si nanotube (SiNT) arrays have been fabricated and demonstrated to be an attractive matrix to accommodate macromolecules, such as proteins, and exhibit facile direct electrochemistry of cytochrome c without any pretreatment. A pair of well-defined redox waves can be observed in the aqueous solution containing cytochrome c on this SiNT electrode using cyclic voltammetry. The peak separation (DeltaEp) between the anodic and the cathodic peaks is 63 mV at the sweep rate of 10 mV/s, and the peak current is proportional to the square root of the sweep rates, which indicates that the redox process is a quasi-reversible process. The experimental results show that the good biocompatibility and nanoscale hollow structure of the SiNT arrays can be applicable to preparing Si-based biosensors and protein characterizations.
authors.affiliation: Beijing National Laboratory for Molecular Sciences, State Key Laboratory for Structural Chemistry of Unstable and Stable Species, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China.
authors.forename: Cheng
authors.initials: C
authors.lastname: Mu
authors.forename: Qiang
authors.initials: Q
authors.lastname: Zhao
authors.forename: Dongsheng
authors.initials: D
authors.lastname: Xu
authors.forename: Qiankun
authors.initials: Q
authors.lastname: Zhuang
authors.forename: Yuanhua
authors.initials: Y
authors.lastname: Shao
mesh_terms: D015374:Biosensing Techniques; D045304:Cytochromes c / Q000737:chemistry*; D004563:Electrochemistry; D004566:Electrodes; D006046:Gold / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D008855:Microscopy, Electron, Scanning; D043942:Nanotubes / Q000737:chemistry*; D010084:Oxidation-Reduction; D012825:Silicon / Q000737:chemistry*
chemical_list: D006046:Gold; D045304:Cytochromes c; D012825:Silicon