JAK3 mutations occur in acute megakaryoblastic leukemia both in Down syndrome children and non-Down syndrome adults.
Kiyoi
H
H
Yamaji
S
S
Kojima
S
S
Naoe
T
T
D000328:Adult; D001665:Binding Sites / Q000235:genetics; D002648:Child; D004252:DNA Mutational Analysis; D004273:DNA, Neoplasm / Q000235:genetics; D018450:Disease Progression; D004314:Down Syndrome / Q000150:complications*; D004789:Enzyme Activation / Q000235:genetics; D005260:Female; D050982:GATA1 Transcription Factor / Q000235:genetics; D011905:Genes, ras; D020022:Genetic Predisposition to Disease; D006801:Humans; D053631:Interleukin Receptor Common gamma Subunit / Q000378:metabolism; D053616:Janus Kinase 3 / Q000235:genetics*; D007947:Leukemia, Megakaryoblastic, Acute / Q000150:complications / Q000201:enzymology / Q000235:genetics*; D008297:Male; D009196:Myeloproliferative Disorders / Q000150:complications / Q000201:enzymology / Q000235:genetics*; D009363:Neoplasm Proteins / Q000235:genetics*; D017434:Protein Structure, Tertiary; D013329:Structure-Activity Relationship; D016159:Tumor Suppressor Protein p53 / Q000235:genetics; D051941:fms-Like Tyrosine Kinase 3 / Q000235:genetics
D004273:DNA, Neoplasm; D050982:GATA1 Transcription Factor; C494688:GATA1 protein, human; D053631:Interleukin Receptor Common gamma Subunit; D009363:Neoplasm Proteins; D016159:Tumor Suppressor Protein p53; C497970:FLT3 protein, human; D051941:fms-Like Tyrosine Kinase 3; C507933:JAK3 protein, human; D053616:Janus Kinase 3