title: Is Her-2/neu expressed in nonepithelial ovarian malignancies?
abstract: OBJECTIVE
  The objective of this study was to assess the expression of Her-2/neu in nonepithelial ovarian malignancies.
  
  
  METHODS
  Formalin-fixed paraffin-embedded archival tissue blocks of 20 unselected nonepithelial ovarian malignancies (12 granulosa cell tumors and 8 germ cell tumors) diagnosed between 1993 and 2005 were immunohistochemically stained for Her-2/neu.
  
  
  RESULTS
  Immunohistochemical staining for Her-2/neu was not present in any of these nonepithelial malignancies examined.
  
  
  CONCLUSIONS
  Our limited sample size does not allow a generalized conclusion concerning the lack of Her-2/neu expression in nonepithelial ovarian malignancies, but it adds information with regard to the expression of this oncogene in these rare neoplasms and seems to indicate that it is not a frequent occurrence.
authors.affiliation: Gynecologic Oncology Unit, Department of Obstetrics and Gynecology, E. Wolfson Medical Center, Holon, Israel.
authors.forename: Joseph
authors.initials: J
authors.lastname: Menczer
authors.forename: Letizia
authors.initials: L
authors.lastname: Schreiber
authors.forename: Bernard
authors.initials: B
authors.lastname: Czernobilsky
authors.forename: Esther
authors.initials: E
authors.lastname: Berger
authors.forename: Abraham
authors.initials: A
authors.lastname: Golan
authors.forename: Tally
authors.initials: T
authors.lastname: Levy
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D018734:Genes, erbB-2 / Q000235:genetics*; D006106:Granulosa Cell Tumor / Q000378:metabolism*; D006801:Humans; D008875:Middle Aged; D009373:Neoplasms, Germ Cell and Embryonal / Q000235:genetics*; D010051:Ovarian Neoplasms / Q000378:metabolism*