title: Anti-mycobacterial activity of a bis-sulfonamide.
abstract: A bis-arylsulfonamide, 7, has been identified that exhibits growth inhibition of Mycobacterium smegmatis at less than 25 microg/mL, but has no such activity against Escherichia coli or Staphylococcus aureus. A closely related bis-arylsulfonamide (8) was much less active, but was the only other compound among 54 arylsulfonamides tested with detectable growth inhibition of M. smegmatis.
authors.affiliation: Eskitis Institute for Cell and Molecular Therapies, Griffith University, Nathan, Qld 4111, Australia.
authors.forename: Brendan L
authors.initials: BL
authors.lastname: Wilkinson
authors.forename: Laurent F
authors.initials: LF
authors.lastname: Bornaghi
authors.forename: Anthony D
authors.initials: AD
authors.lastname: Wright
authors.forename: Todd A
authors.initials: TA
authors.lastname: Houston
authors.forename: Sally-Ann
authors.initials: SA
authors.lastname: Poulsen
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects; D020102:Mycobacterium smegmatis / Q000187:drug effects*; D013211:Staphylococcus aureus / Q000187:drug effects; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D013449:Sulfonamides