title: Hypermetabolic change as a possible predictive sign of a relapsed central nervous system lymphoma.
abstract: OBJECTIVE
  A patient with abdominal lymphoma who had been in complete remission for 6 years presented with a 1-month history of dysarthria. The aim of our report is to discuss the discordance of the patient's results between magnetic resonance (MR) imaging and F-18 fluorodeoxyglucose (FDG) positron emission tomography (PET).
  
  
  METHODS
  After the onset, FDG PET and brain MR imaging were performed. The FDG PET study included whole-body and brain scan. The MR study included pre- and postcontrast T1, T2, fluid-attenuated inversion recovery and diffusion-weighted sequences.
  
  
  RESULTS
  Brain MR imaging showed a localized abnormal signal around the left Sylvian fissure in any sequence, although a postcontrast study exhibited poor enhancement in the lesion. Brain PET showed a widespread area of slightly increased uptake in the brain on the left side, which was quite inconsistent with the MR results. After 4 months, follow-up MR imaging revealed a widespread abnormal signal, with enhancing masses, in the hypermetabolic region.
  
  
  CONCLUSIONS
  Hypermetabolic changes on FDG PET preceded signal changes on MR imaging, potentially suggesting that hypermetabolism occurred in the microscopic infiltration of lymphoma cells.
authors.affiliation: Department of Radiology, Keio University School of Medicine, Tokyo, Japan. n-tadaki0909@k6.dion.ne.jp
authors.forename: Tadaki
authors.initials: T
authors.lastname: Nakahara
authors.forename: Yaeko
authors.initials: Y
authors.lastname: Takagi
authors.forename: Hayao
authors.initials: H
authors.lastname: Shiga
authors.forename: Hideo
authors.initials: H
authors.lastname: Uchida
authors.forename: Junichi
authors.initials: J
authors.lastname: Kaburaki
authors.forename: Atsushi
authors.initials: A
authors.lastname: Kubo
mesh_terms: D016543:Central Nervous System Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000378:metabolism*; D004401:Dysarthria / Q000473:pathology; D019788:Fluorodeoxyglucose F18 / Q000378:metabolism; D006801:Humans; D008223:Lymphoma / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000378:metabolism*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography; D011379:Prognosis; D011859:Radiography; D012008:Recurrence
chemical_list: D019788:Fluorodeoxyglucose F18