[Chemical constituents from red alga Corallina pilulifera].
OBJECTIVE
To investigate the chemical constituents of red alga Corallina pilulifera.


METHODS
Compounds were isolated by normal phase silica gel and Sephadex LH - 20 gel column chromatography, reverse phase HPLC and recrystallization. Their structures were elucidated by spectroscopic methods including MS, 1H-NMR, 13C-NMR, HSQC, HMBC. Cytotoxicity of the compounds was screened by using standard MTT method.


RESULTS
Seven compounds were isolated from red alga C. pilulifera, their structures were identified as (E) -phytol epoxide (1), phytenal (2), phytol (3), dehydrovomifoliol (4), loliolide (5), 3beta-hydroxy-5alpha, 6alpha-epoxy-7-megastigmene-9-one (6), 4-hydroxybenzaldehyde (7).


CONCLUSIONS
All of the compounds were obtained from this species for the first time. These compounds were inactive (IC50 > 10 microg x mL(-1)) in the MTT assay.
Yuan
Zhao-Hui
ZH
Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China.
Han
Li-Jun
LJ
Fan
Xiao
X
Li
Shuai
S
Shi
Da-Yong
DY
Sun
Jie
J
Ma
Ming
M
Yang
Yong-Chun
YC
Shi
Jian-Gong
JG
D001547:Benzaldehydes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001572:Benzofurans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D045744:Cell Line, Tumor / Q000187:drug effects; D006801:Humans; D010836:Phytol / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000461:Rhodophyta / Q000737:chemistry*
D001547:Benzaldehydes; D001572:Benzofurans; D010836:Phytol; C011483:4-hydroxybenzaldehyde; C030425:loliolide