Type II protein C deficiency in a 16-year-old girl with central retinal vein occlusion.
OBJECTIVE
To report a case of central retinal vein occlusion in the setting of type II protein C deficiency, and to describe the appropriate tests for detecting this clotting abnormality.


METHODS
Observational case report.


METHODS
Retrospective review of clinical examination and laboratory findings.


RESULTS
A 16-year-old girl was evaluated for progressive monocular vision loss occurring over a period of one month. Dilated fundus examination and fluorescein angiography revealed the presence of a central retinal vein occlusion. Hypercoagulable work-up demonstrated normal protein C antigen levels, but a marked reduction in protein C function, confirming a type II protein C deficiency.


CONCLUSIONS
Central retinal vein occlusion may be associated with type II protein C deficiency. Testing for protein C antigen levels and function is necessary for detection of both type I and type II protein C deficiency.
Vrabec
Joshua P
JP
Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, Wisconsin 53792, USA.
Levin
Leonard A
LA
D000293:Adolescent; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D020151:Protein C Deficiency / Q000175:diagnosis* / Q000235:genetics; D012170:Retinal Vein Occlusion / Q000175:diagnosis*; D012189:Retrospective Studies; D014786:Vision Disorders / Q000175:diagnosis; D014792:Visual Acuity