title: C-Alkyl 5-membered ring imino sugars as new potent cytotoxic glucosylceramide synthase inhibitors.
abstract: The stereoselective preparation of novel C-alkyl 5-membered ring imino sugars and their biological evaluation with regard to GCS inhibition and cytotoxicity in a murine melanoma model are reported.
authors.affiliation: Laboratoire de Synthèse et Physicochimie de Molécules d'Intérêt Biologique, UMR 5068CNRS/Université Paul Sabatier, 118 route de Narbonne, 31062, Toulouse Cedex 9, France.
authors.forename: Vanessa
authors.initials: V
authors.lastname: Faugeroux
authors.forename: Yves
authors.initials: Y
authors.lastname: Génisson
authors.forename: Nathalie
authors.initials: N
authors.lastname: Andrieu-Abadie
authors.forename: Sandra
authors.initials: S
authors.lastname: Colié
authors.forename: Thierry
authors.initials: T
authors.lastname: Levade
authors.forename: Michel
authors.initials: M
authors.lastname: Baltas
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D005964:Glucosyltransferases / Q000037:antagonists & inhibitors*; D006801:Humans; D050111:Imino Sugars / Q000737:chemistry* / Q000494:pharmacology*; D015394:Molecular Structure; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; D050111:Imino Sugars; D005964:Glucosyltransferases; C023246:ceramide glucosyltransferase