Venom of Indian monocellate cobra and Russell's viper show anticancer activity in experimental models.
Indian monocellate cobra (Naja kaouthia) and Russell's viper (Vipera russelli) are common snakes of the East Indian sub-peninsula. The anticarcinogenic activities of their crude venoms were studied on carcinoma, sarcoma and leukemia models. Sub-lethal doses of venoms showed cytotoxicity on Ehrlich ascites carcinoma (EAC) cells in vivo. The venoms increased lifespan of EAC mice and strengthened the impaired host antioxidant system. Sarcoma formation in mice (3-methylcholanthrene induced) after venom treatment was significantly less (p < 0.005). Histopathological examination of tumors showed tissue necrosis. The venoms displayed potent cytotoxic and apoptogenic effect on human leukemic cells (U937/K562). The venoms reduced cell proliferation rate (p < 0.005) and produced morphological alterations indicative of apoptosis induction. Different degree and nature of anticarcinogenic property of cobra and viper venoms may be attributed to the difference in their constituents.
Debnath
Anindita
A
Drug Development Division, Indian Institute of Chemical Biology, 4 Raja S.C. Mullick Road, Kolkata 700032, India.
Chatterjee
Uttora
U
Das
Minati
M
Vedasiromoni
Joseph R
JR
Gomes
Aparna
A
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D000975:Antioxidants / Q000378:metabolism; D017209:Apoptosis / Q000187:drug effects; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004195:Disease Models, Animal; D004546:Elapid Venoms / Q000008:administration & dosage / Q000494:pharmacology*; D017815:Elapidae; D006801:Humans; D007194:India; D007928:Lethal Dose 50; D051379:Mice; D008807:Mice, Inbred BALB C; D009336:Necrosis / Q000473:pathology; D017840:Daboia; D015996:Survival Rate; D014757:Viper Venoms / Q000008:administration & dosage / Q000494:pharmacology*
D000970:Antineoplastic Agents; D000975:Antioxidants; D004546:Elapid Venoms; D014757:Viper Venoms