title: Oncological outcome of ultra-low coloanal anastomosis with and without intersphincteric resection for low rectal adenocarcinoma.
abstract: BACKGROUND
  The value of ultra-low coloanal anastomosis (CAA) for rectal cancer is dependent on the oncological and functional results. The aim of this comparative study was to evaluate the long-term oncological outcome of CAA with or without intersphincteric resection (ISR) for low-lying rectal tumours.
  
  
  METHODS
  The study population comprised consecutive patients with low rectal cancer who underwent CAA in a single institution between 1977 and 2004. Patients were divided into two groups according to whether or not a partial ISR had been performed. Cox multivariate models were used for survival analysis.
  
  
  RESULTS
  Some 278 patients underwent CAA with curative intent; 173 had ISR and 105 had CAA without ISR. Mean follow-up was 66.8 months. The 5-year actuarial rate for local recurrence, regardless of tumour stage, was 10.6 per cent in the ISR group versus 6.7 per cent for CAA alone (P = 0.405), and the 5-year actuarial overall survival rate was 86.1 and 80.0 per cent respectively (P = 0.318). Cox multivariable analysis revealed that resection of the anal canal was not a prognostic factor for local or metastatic recurrence.
  
  
  CONCLUSIONS
  Sphincter-preserving surgery appears to be oncologically adequate for very low-lying rectal tumours.
authors.affiliation: Service de Chirurgie Digestive, Hôpital Purpan, Centre Hospitalier Universitaire de Toulouse, France. portier.g@chu-toulouse.fr
authors.forename: G
authors.initials: G
authors.lastname: Portier
authors.forename: L
authors.initials: L
authors.lastname: Ghouti
authors.forename: S
authors.initials: S
authors.lastname: Kirzin
authors.forename: R
authors.initials: R
authors.lastname: Guimbaud
authors.forename: M
authors.initials: M
authors.lastname: Rives
authors.forename: F
authors.initials: F
authors.lastname: Lazorthes
mesh_terms: D000230:Adenocarcinoma / Q000401:mortality / Q000601:surgery*; D000368:Aged; D000714:Anastomosis, Surgical / Q000379:methods; D015331:Cohort Studies; D039021:Colonic Pouches; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local; D016737:Proctocolectomy, Restorative / Q000379:methods*; D012004:Rectal Neoplasms / Q000401:mortality / Q000601:surgery*; D015996:Survival Rate; D016896:Treatment Outcome