Can single-kidney glomerular filtration rate be determined with contrast-enhanced CT?
Daghini et al used a pig model to estimate single-kidney GFR with dynamic contrast-enhanced CT scanning. Three techniques were evaluated, two of which (the modified Patlak method and the gamma variate model) yielded GFR estimates that correlated significantly with determinations made by using standard inulin clearance techniques. The findings hold promise that noninvasive in vivo assessment of single-kidney renal function may be achieved in patients.
Sommer
F Graham
FG
Department of Radiology, Stanford University Medical Center, 300 Pasteur Dr, H-1307, Stanford, CA 94305-5105, USA. gsommer@stanford.edu
D000818:Animals; D003287:Contrast Media; D005919:Glomerular Filtration Rate / Q000502:physiology*; D006801:Humans; D007668:Kidney / Q000000981:diagnostic imaging / Q000502:physiology*; D007674:Kidney Diseases / Q000000981:diagnostic imaging / Q000503:physiopathology; D011856:Radiographic Image Enhancement / Q000379:methods*; D013552:Swine; D014057:Tomography, X-Ray Computed / Q000379:methods*
D003287:Contrast Media