Lipid peroxidation and inflammatory molecules as markers of coronary artery disease.
Oxidized low density lipoproteins (oxLDLs) may exert several pro-inflammatory effects that can contribute to the development of coronary artery disease (CAD). Evaluating a possible correlation between oxLDLs and clinical expression of CAD, we measured specific lipid peroxidation indices in healthy subjects and in patients at different clinical stages of CAD. We observed a slight, but not significant, increase in plasma content of cholesterol oxidation products, i.e. oxysterols, in all CAD patients, and a slight, but not significant, increase of 4-hydroxynonenal-protein adducts only in subjects with acute CAD. Moreover, CAD patients showed a plasma rise of specific inflammatory proteins, i.e. C-reactive protein, intercellular adhesion molecule-1, and interleukin-8, but not of monocyte chemotactic protein-1. These preliminary data, without excluding an involvement of oxidative stress and inflammation in CAD, do not show a strict correlation between relevant plasma markers, other than C-reactive protein, and acute phase of the disease.
Sottero
Barbara
B
Department of Clinical and Biological Sciences, University of Torino, San Luigi Gonzaga Hospital, Orbassano (Torino), Italy.
Pozzi
Roberto
R
Leonarduzzi
Gabriella
G
Aroasio
Emiliano
E
Gamba
Paola
P
Gargiulo
Simona
S
Rabajoli
Filippo
F
Ferrari
Fabio
F
Greco Lucchina
Pietro
P
Poli
Giuseppe
G
D000368:Aged; D000369:Aged, 80 and over; D000447:Aldehydes / Q000493:pharmacokinetics*; D015703:Antigens, CD / Q000097:blood; D015415:Biomarkers / Q000097:blood*; D001798:Blood Proteins / Q000378:metabolism*; D002097:C-Reactive Protein / Q000032:analysis; D015815:Cell Adhesion Molecules / Q000097:blood; D018932:Chemokine CCL2 / Q000097:blood; D003327:Coronary Disease / Q000097:blood* / Q000503:physiopathology; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood*; D016209:Interleukin-8 / Q000097:blood; D015227:Lipid Peroxidation; D008297:Male; D008875:Middle Aged; D012016:Reference Values
D000447:Aldehydes; D015703:Antigens, CD; D015415:Biomarkers; D001798:Blood Proteins; C111835:CCL2 protein, human; D015815:Cell Adhesion Molecules; D018932:Chemokine CCL2; C483616:ICAM3 protein, human; D016209:Interleukin-8; D002097:C-Reactive Protein; C027576:4-hydroxy-2-nonenal