Cardiovascular effects of herbicides and formulated adjuvants on isolated rat aorta and heart.
Various formulations of agricultural chemicals, including solutions, wettable powders, and emulsifiable concentrates, contain adjuvants of solvents and surfactants in addition to active ingredients. Among these formulations, herbicides are among the most commonly used pesticides globally. Some pesticides have been demonstrated to cause severe circulatory failure in poisoned humans. To clarify the potential risk of herbicides and their adjuvants influence on the cardiovascular system, four technical grade (TG) herbicides and their end products (EP), including paraquat, glyphosate, glufosinate, and atrazine, as well as their formulated adjuvants isopropylamine (IPA), polyoxyethylene alkylether sulfate (AES), ethyl acetate (EA), xylene, petrolium-170 (P-170), and solvesso-100 (S-100), were assessed to determine their effects on isolated rat aorta and heart. The results revealed that the vasorelaxation effects of the herbicide EPs exceeded those of TGs, and atrazine produced more significant vasorelaxation in rat aortas than the other herbicides tested. The formulated adjuvants of IPA did not affect the aorta; however, AES, EA, xylene, P-170 and S-100 caused significant vasorelaxation. Herbicide EPs-induced vasorelaxation was generally endothelium-dependent. Furthermore, the TG and EP of paraquat, and the TG of glufosinate and glyphosate were found to have no effect on the isolated heart. However, the normal twitch tensions of the isolated heart were significantly inhibited by EPs of glyphosate and glufosinate, and by TG and EP of atrazine. Although, the adjuvants of IPA appeared unaffected, however, AES, EA, xylene, P-170 and S-100 caused complete inhibition and contraction on the isolated hearts. These results indicated that the adjuvants of herbicides might enhance hypotension and contributed to cardiovascular disorders during intoxication.
Chan
Yin-Ching
YC
Department of Food and Nutrition, Providence University, Taichung 433, Taiwan, ROC.
Chang
Shih-Chieh
SC
Hsuan
Shih-Ling
SL
Chien
Maw-Sheng
MS
Lee
Wei-Cheng
WC
Kang
Jaw-Jou
JJ
Wang
Shun-Cheng
SC
Liao
Jiunn-Wang
JW
D000277:Adjuvants, Pharmaceutic / Q000633:toxicity*; D000818:Animals; D001013:Aorta, Thoracic / Q000473:pathology; D001808:Blood Vessels / Q000187:drug effects* / Q000473:pathology*; D002319:Cardiovascular System / Q000187:drug effects* / Q000473:pathology; D002626:Chemistry, Pharmaceutical; D006321:Heart / Q000187:drug effects*; D006540:Herbicides / Q000633:toxicity*; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009126:Muscle Relaxation / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D009206:Myocardium / Q000473:pathology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012997:Solvents / Q000633:toxicity
D000277:Adjuvants, Pharmaceutic; D006540:Herbicides; D012997:Solvents