Post-translational modifications regulate the ticking of the circadian clock.
Getting a good night's sleep is on everyone's to-do list. So is, no doubt, staying awake during late afternoon seminars. Our internal clocks control these and many more workings of the body, and disruptions of the circadian clocks predispose individuals to depression, obesity and cancer. Mutations in kinases and phosphatases in hamsters, flies, fungi and humans highlight how our timepieces are regulated and provide clues as to how we might be able to manipulate them.
Gallego
Monica
M
Center for Children, Huntsman Cancer Institute, Salt Lake City, Utah 84112, USA. Monica.Gallego@hci.utah.edu
Virshup
David M
DM
D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism; D021081:Chronobiology Disorders / Q000209:etiology; D002940:Circadian Rhythm; D004331:Drosophila melanogaster / Q000201:enzymology / Q000378:metabolism / Q000502:physiology*; D025461:Feedback, Physiological; D005786:Gene Expression Regulation; D006801:Humans; D009492:Neurospora crassa / Q000201:enzymology / Q000502:physiology*; D010744:Phosphoric Monoester Hydrolases / Q000378:metabolism / Q000502:physiology; D010766:Phosphorylation; D010770:Phosphotransferases / Q000378:metabolism / Q000502:physiology; D011499:Protein Processing, Post-Translational; D015398:Signal Transduction
D010770:Phosphotransferases; D010744:Phosphoric Monoester Hydrolases