title: Importance of realistic sample size calculations and why the next randomized trial needs to be large and multicentered.
authors.forename: Thomas S T
authors.initials: TS
authors.lastname: Li
authors.forename: Anna
authors.initials: A
authors.lastname: Lee
authors.forename: Gavin M
authors.initials: GM
authors.lastname: Joynt
mesh_terms: D006801:Humans; D015337:Multicenter Studies as Topic; D016032:Randomized Controlled Trials as Topic / Q000592:standards / Q000706:statistics & numerical data*; D018401:Sample Size