Two new 6-alkylcoumarins from Angelica pubescens f. biserrata.
Two new 6-alkylcoumarins, angelitriol (1) and angelol J (2), were isolated from the EtOAc-soluble fraction of the roots of Angelica pubescens Maxim f. biserrata Shan et Yuan. Their structures were elucidated as 6-[(1R,2S)-1,2,3-trihydroxy-3-methylbutyl]-7-methoxycoumarin (1) and 6-[(1R,2R)-1-ethoxy-2,3-dihydroxy-3-methylbutyl]-7-methoxycoumarin (2), respectively, on the basis of spectral evidence. Both of them showed strong inhibitory effects on human platelet aggregation.
Liu
J H
JH
Xu
S X
SX
Yao
X S
XS
Kobayashi
H
H