Neurotoxic prion protein (PrP) fragment 106-126 requires the N-terminal half of the hydrophobic region of PrP in the PrP-deficient neuronal cell line.
The cytotoxicity of aged PrP(106-126) was examined using an immortalized prion protein (PrP) gene-deficient neuronal cell line. The N-terminal half of the hydrophobic region (HR) but not the octapeptide repeat (OR) of PrP was required for aged PrP(106-126) neurotoxicity, suggesting that neurotoxic signals of aged PrP(106-126) are mediated by this region.
Sakudo
Akikazu
A
Department of Molecular Immunology, School of Agricultural and Life Sciences, University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan.
Nakamura
Izuru
I
Lee
Deug-Chan
DC
Saeki
Keiichi
K
Ikuta
Kazuyoshi
K
Onodera
Takashi
T
D016923:Cell Death / Q000187:drug effects; D002460:Cell Line; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D009474:Neurons / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism*; D010446:Peptide Fragments / Q000737:chemistry* / Q000633:toxicity*; D011328:Prions / Q000737:chemistry* / Q000633:toxicity*; D013482:Superoxide Dismutase
D010446:Peptide Fragments; D011328:Prions; D013482:Superoxide Dismutase