title: A new class of anti-MRSA and anti-VRE agents: preparation and antibacterial activities of indole-containing compounds.
abstract: A new class of indole-containing compounds were prepared by the use of three component reaction and their in vitro antibacterial activities (MIC) were evaluated against Staphylococcus aureus and Enterococcus faecium including MRSA and VRE.
authors.affiliation: Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd, 760 Morooka-cho, Kohoku-ku, Yokohama 222-8567, Japan. yasuo_yamamoto@meiji.co.jp
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Yamamoto
authors.forename: Mizuyo
authors.initials: M
authors.lastname: Kurazono
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D016983:Enterococcus / Q000187:drug effects*; D007202:Indicators and Reagents; D007211:Indoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D016106:Methicillin Resistance / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D013211:Staphylococcus aureus / Q000187:drug effects*; D020713:Vancomycin Resistance / Q000187:drug effects*
chemical_list: D000900:Anti-Bacterial Agents; D007202:Indicators and Reagents; D007211:Indoles