Synthesis of complex-type glycans derived from parasitic helminths.
Chemical syntheses of complex-type glycans derived from the eggs of parasitic helminths, Schistosoma mansoni and Schistosoma japonicum were achieved. In addition, their analogs, which lack xylose and/or fucose residue(s), are described. These branched sugar chains were synthesized regio- and stereoselectively by using beta-mannosylation, desilylation under high-pressure and glycosylation in frozen solvent as key transformations.
Nakano
Jun
J
RIKEN (The Institute of Physical and Chemical Research), Wako, Saitama 351-0198, Japan.
Ishiwata
Akihiro
A
Ohta
Hiromichi
H
Ito
Yukishige
Y
D000818:Animals; D002240:Carbohydrate Sequence; D005643:Fucose / Q000737:chemistry; D006031:Glycosylation; D008358:Mannose / Q000737:chemistry; D011134:Polysaccharides / Q000138:chemical synthesis* / Q000737:chemistry; D012549:Schistosoma japonicum / Q000737:chemistry*; D012550:Schistosoma mansoni / Q000737:chemistry*; D013237:Stereoisomerism; D014994:Xylose / Q000737:chemistry
D011134:Polysaccharides; D005643:Fucose; D014994:Xylose; D008358:Mannose