title: Structure-activity relationships of xanthocillin derivatives as thrombopoietin receptor agonist.
abstract: Xanthocillin derivatives, which show thrombopoietin receptor agonist activity, were synthesized through our developed method. Bioassay data suggest the importance of alkene geometry, the presence of substituents at the benzene ring that support hydrophobic character, and the moderate size of the molecule. One of the two isonitrile group of the natural product appears to be dispensable.
authors.affiliation: Department of Chemistry, School of Science and Engineering, Waseda University, 3-4-1 Ohkubo, Shinjyuku-ku, Tokyo 169-8555, Japan.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Yamaguchi
authors.forename: Yumi
authors.initials: Y
authors.lastname: Miyake
authors.forename: Atsushi
authors.initials: A
authors.lastname: Miyamura
authors.forename: Norihisa
authors.initials: N
authors.lastname: Ishiwata
authors.forename: Kuniaki
authors.initials: K
authors.lastname: Tatsuta
mesh_terms: D002070:Butadienes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009570:Nitriles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D010636:Phenols / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D053628:Receptors, Thrombopoietin / Q000819:agonists*; D013329:Structure-Activity Relationship
chemical_list: D002070:Butadienes; D009570:Nitriles; D010636:Phenols; D053628:Receptors, Thrombopoietin