[Synthesis and antithrombotic activity of acetylsalicyl ferulic acid-coupling furoxans and nitrates].
OBJECTIVE
To synthesize and study the antithrombotic activity of NO-donating aspirin derivatives.


METHODS
Furoxans and nitrates were incorporated to aspirin via antioxidant ferulic acid as a linker, and the target compounds were screened for in vitro and in vivo inhibitory activities of platelet aggregation, and for inhibitory effect on A-V hypass thromhosis in rats.


RESULTS
Fourteen novel compounds I(1-14), were synthesized and their structures were confirmed Iy MS, IR, 1H NMR and elemental analysis. Biological screening results demonstrated that some tested compounds exhibited potential antithrombotic activ it.


CONCLUSIONS
Acetylsalicyl ferulic acid-coupling furoxans and nitrates might he used as a lead for further study.
Zhou
Zhou
Z
Center of Drug Discovery, China Pharmaceutical University, Nanjing 210009, China.
Jiang
Li-yuan
LY
Zhang
Yi-hua
YH
Ji
Hui
H
Sun
Yi
Y
Peng
Si-xun
SX
D000818:Animals; D001241:Aspirin / Q000737:chemistry*; D003373:Coumaric Acids / Q000737:chemistry*; D005343:Fibrinolytic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D008956:Models, Chemical; D015394:Molecular Structure; D009566:Nitrates / Q000737:chemistry*; D020030:Nitric Oxide Donors / Q000737:chemistry; D010069:Oxadiazoles / Q000737:chemistry*; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D051381:Rats
D003373:Coumaric Acids; D005343:Fibrinolytic Agents; D009566:Nitrates; D020030:Nitric Oxide Donors; D010069:Oxadiazoles; D010975:Platelet Aggregation Inhibitors; C010166:furoxans; C004999:ferulic acid; D001241:Aspirin