Guaiane sesquiterpene lactones from Salvia nubicola (Lamiaceae).
A new sesquiterpene lactone, nubiol (1), belonging to the guaiane class, along with a dimer, bisnubidiol (2), has been isolated from Salvia nubicola collected from Quetta, Pakistan. The structures of both metabolites were elucidated with the aid of spectroscopic techniques including 2D-NMR. Additionally, the structure of nubiol (1) was finally confirmed via the single crystal X-ray diffraction. Nubiol (1) was found moderately active against Pseudomonas aeruginosa.
Ali
Muhammad S
MS
H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan. shaiq303@hotmail.com
Ibrahim
Syed A
SA
Ahmed
Shakeel
S
Lobkovsky
Emil
E
D018360:Crystallography, X-Ray; D003508:Cycloheptanes / Q000737:chemistry*; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification*; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D015394:Molecular Structure; D027544:Salvia / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry*; D045789:Sesquiterpenes, Guaiane / Q000737:chemistry*
D003508:Cycloheptanes; D007783:Lactones; D012717:Sesquiterpenes; D045789:Sesquiterpenes, Guaiane; C421026:guaiane