title: Increased adenosine deaminase in hydatidiform mole.
abstract: BACKGROUND
  The aim of the current study was to investigate levels of adenosine deaminase in plasma of patients with hydatidiform mole.
  
  
  METHODS
  Plasma adenosine deaminase levels were determined in 17 women with normal pregnant course, in 17 women with hydatidiform mole, and in 17 non-pregnant healthy volunteers.
  
  
  RESULTS
  Mean adenosine deaminase activity in the hydatidiform mole group was 121.5+/-24.8 U/L, significantly higher than in the pregnant control (7.8+/-6.5 U/L; p<0.0001) and non-pregnant control groups (6.4+/-7.4 U/L; p<0.0001). A cutoff level of 40.5 U/L was found, with both sensitivity and specificity of 100%.
  
  
  CONCLUSIONS
  Adenosine deaminase may play a role in the development of hydatidiform mole.
authors.affiliation: Department of Obstetrics and Gynecology, School of Medicine, Inonu University, Malatya, Turkey. ustunyaprak@yahoo.com
authors.forename: Yaprak
authors.initials: Y
authors.lastname: Engin-Ustün
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Ustün
authors.forename: Aysun Bay
authors.initials: AB
authors.lastname: Karabulut
authors.forename: Keziban
authors.initials: K
authors.lastname: Doğan
authors.forename: M Mutlu
authors.initials: MM
authors.lastname: Meydanli
authors.forename: Bülent
authors.initials: B
authors.lastname: Sezgin
mesh_terms: D000243:Adenosine Deaminase / Q000097:blood*; D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D006828:Hydatidiform Mole / Q000097:blood / Q000201:enzymology*; D011247:Pregnancy; D015854:Up-Regulation
chemical_list: D000243:Adenosine Deaminase