New approach to the synthesis of macrocyclic tetralactones via ring-closing metathesis using Grubbs' first-generation catalyst.
A facile and efficient route to synthesize macrocyclic tetralactones with different ring sizes having a wide variety of spacers is described. The application of ring-closing metathesis for the synthesis of macrocyclic tetralactones is demonstrated with many examples in excellent yield. The representative structure of macrocyclic tetralactones is characterized by X-ray crystallography.
Muthusamy
Sengodagounder
S
School of Chemistry, Bharathidasan University, Tiruchirappalli, Tamilnadu 620 024, India. muthu@bdu.ac.in
Gnanaprakasam
Boopathy
B
Suresh
Eringathodi
E