title: Voriconazole and fungal keratitis: a report of two treatment failures.
abstract: Two cases of fungal keratitis, one caused by Fusarium oxysporum and the other by Colletotrichum dematium, that failed treatment with topical voriconazole 1% are presented. These cases are noteworthy in that topical voriconazole was unable to eradicate the corneal infection in both cases, despite relatively low MIC90 tested for each species of 8 and 1 microg/mL, respectively.
authors.affiliation: Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami Miller School of Medicine, Miami, FL, USA. giaconi@jsei.ucla.edu
authors.forename: JoAnn A
authors.initials: JA
authors.lastname: Giaconi
authors.forename: Fabiana B
authors.initials: FB
authors.lastname: Marangon
authors.forename: Darlene
authors.initials: D
authors.lastname: Miller
authors.forename: Eduardo C
authors.initials: EC
authors.lastname: Alfonso
mesh_terms: D000287:Administration, Topical; D000369:Aged, 80 and over; D000935:Antifungal Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D020231:Colletotrichum / Q000187:drug effects / Q000302:isolation & purification; D005670:Fusarium / Q000187:drug effects / Q000302:isolation & purification; D006801:Humans; D007634:Keratitis / Q000188:drug therapy* / Q000382:microbiology; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D009181:Mycoses / Q000188:drug therapy* / Q000382:microbiology; D011743:Pyrimidines / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D017211:Treatment Failure; D014230:Triazoles / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D065819:Voriconazole
chemical_list: D000935:Antifungal Agents; D011743:Pyrimidines; D014230:Triazoles; D065819:Voriconazole