System properties of ErbB receptor signaling for the understanding of cancer progression.
An intracellular signal transduction network constitutes an assembled machinery to control the dynamics of kinase-phosphatase cascade and gene expression. Spatio-temporal analyses of the cellular process can explain the biochemical role of the receptor tyrosine kinases in cancer development from a system point of view.
Hatakeyama
Mariko
M
Cellular Systems Biology Team, RIKEN Genomic Sciences Center, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan. marikoh@gsc.riken.jp
D000818:Animals; D019281:Dimerization; D018450:Disease Progression; D004815:Epidermal Growth Factor / Q000378:metabolism; D066246:ErbB Receptors / Q000378:metabolism / Q000502:physiology*; D025461:Feedback, Physiological; D006801:Humans; D008954:Models, Biological; D009369:Neoplasms / Q000378:metabolism*; D015398:Signal Transduction
D004815:Epidermal Growth Factor; D066246:ErbB Receptors