Sesquiterpene peroxides from Senecio selloi and Eupatorium rufescens.
Two bisabolane-type sesquiterpenes, zingiberene-3,6-beta-endoperoxide (1) and zingiberene-3,6-alpha-endoperoxide (2) have been isolated from the aerial parts of Senecio selloi and Eupatorium rufescens. Their structures were determined by spectroscopic methods. Both compounds show schizonticidal activity against Plasmodium falciparum (EC50 = 10 microg/ml).
Rücker
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Pharmazeutisches Institut, Universität Bonn, Kreuzbergweg 26, D-53115 Bonn, Germany.
Schenkel
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EP
Manns
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D
Mayer
R
R
Heiden
K
K
Heinzmann
B M
BM