Synthesis of lactams by radical substitution reaction of alpha,beta-unsaturated acyl radicals at amine nitrogen.
[reaction: see text] Substitution at nitrogen by alpha,beta-unsaturated acyl radicals took place accompanied by elimination of an alpha-phenethyl radical. This reaction led to the development of a new carbonylative annulation method for five- to seven-membered ring lactams.
Uenoyama
Yoshitaka
Y
Department of Chemistry, Graduate School of Science, Osaka Prefecture University, Sakai, Osaka 599-8531, Japan.
Fukuyama
Takahide
T
Ryu
Ilhyong
I