title: Sensory gating in patients with Alzheimer's disease and their biological children.
abstract: Research has shown that sensory gating is largely modualted by acetylcholine. Diminished levels of acetylcholine and sensory gating deficits have been reported in research involving Alzheimer's disease (AD) patients. However, there has been little investigation into those with a family history (FH+) of AD. The rationale of this study was to determine whether sensory gating impairments could distinguish those with early AD from individuals with increased risk for the disease while replicating previous findings of gating abnormalities in AD patients. Using the paried-click paradigm, evoked potentials were recorded from 4 groups of 20 subjects per group (AD, older controls, FH+, FH-). The results showed that while the AD group demonstrated sensory gating abnormalities, the FH+ group did not when compared to their peers with no family history of the disease (FH-). These results are discussed in relation to previous findings reporting P300 abnormalities in the FH+ group.
authors.affiliation: Edith Nourse Rogers Memorial Veteran's Hospital, GRECC, Bedford, Massachusetts 01730, USA. bally@bu.edu
authors.forename: Brandon A
authors.initials: BA
authors.lastname: Ally
authors.forename: Gary E
authors.initials: GE
authors.lastname: Jones
authors.forename: Jack A
authors.initials: JA
authors.lastname: Cole
authors.forename: Andrew E
authors.initials: AE
authors.lastname: Budson
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000188:drug therapy / Q000453:epidemiology* / Q000235:genetics*; D002648:Child; D016241:Child of Impaired Parents / Q000706:statistics & numerical data*; D002800:Cholinesterase Inhibitors / Q000627:therapeutic use; D003072:Cognition Disorders / Q000175:diagnosis / Q000453:epidemiology; D004569:Electroencephalography; D005071:Evoked Potentials / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D012678:Sensation Disorders / Q000175:diagnosis / Q000453:epidemiology* / Q000503:physiopathology*; D012720:Severity of Illness Index
chemical_list: D002800:Cholinesterase Inhibitors