Selective intercalation of six ligand molecules in a self-assembled triple helix.
The addition of a ligand molecule to an artificial self-assembled triple helix leads to the selective intercalation of two hydrogen-bonded trimers in specific binding pockets. Furthermore, the triple helix suffers large conformational rearrangements in order to accommodate the ligand molecules in a highly organized manner.
Mateos-Timoneda
Miguel A
MA
Laboratory of Supramolecular Chemistry and Technology, MESA+ Institute for Nanotechnology, Faculty of Sciences and Technology, University of Twente, P. O. Box 217, 7500AE Enschede, The Netherlands.
Kerckhoffs
Jessica M C A
JM
Reinhoudt
David N
DN
Crego-Calama
Mercedes
M
D001665:Binding Sites; D002468:Cell Physiological Phenomena; D004247:DNA / Q000737:chemistry*; D006860:Hydrogen Bonding; D007364:Intercalating Agents / Q000737:chemistry*; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D018716:Molecular Mimicry; D009690:Nucleic Acid Conformation; D011506:Proteins / Q000737:chemistry
D007364:Intercalating Agents; D008024:Ligands; D011506:Proteins; D004247:DNA