title: Structure of the autism symptom phenotype: A proposed multidimensional model.
abstract: BACKGROUND
  The main objective of this study was to develop a comprehensive, empirical model that will allow the reorganization of the structure of the pervasive developmental disorder symptom phenotype through factor analysis into more homogeneous dimensions.
  
  
  METHODS
  The sample consisted of 209 children with pervasive developmental disorder referred for genetic studies. The 12 subdomains of the Autism Diagnostic Interview-Revised were used in a factor analysis, and the emerged factors were then correlated with independent variables (measures of cognition, adaptive function, and diagnostic subtype). Intraclass correlation coefficients were calculated to investigate any familial relationships between sibling pairs on the derived factors.
  
  
  RESULTS
  The autism symptom phenotype is indeed made up of three factors or domains that are somewhat different than those used in DSM-IV. Rather, domains include social-communication, inflexible language and behavior, and repetitive sensory and motor behavior. For the three factors, only a small amount of variance was accounted for by cognitive and adaptive functioning. Only inflexible language and behavior showed familial correlation between siblings.
  
  
  CONCLUSIONS
  The pervasive developmental disorder symptom phenotype is composed of three domains or factors: social-communication, inflexible language and behavior, and repetitive sensory and motor behavior. Each child with pervasive developmental disorder can be characterized by these dimensions, which give an informative picture of the clinical presentation and a quantitative estimate of the severity of the disability.
authors.affiliation: Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada.
authors.forename: Stelios
authors.initials: S
authors.lastname: Georgiades
authors.forename: Peter
authors.initials: P
authors.lastname: Szatmari
authors.forename: Lonnie
authors.initials: L
authors.lastname: Zwaigenbaum
authors.forename: Eric
authors.initials: E
authors.lastname: Duku
authors.forename: Susan
authors.initials: S
authors.lastname: Bryson
authors.forename: Wendy
authors.initials: W
authors.lastname: Roberts
authors.forename: Jeremy
authors.initials: J
authors.lastname: Goldberg
authors.forename: William
authors.initials: W
authors.lastname: Mahoney
mesh_terms: D000293:Adolescent; D020817:Asperger Syndrome / Q000175:diagnosis* / Q000235:genetics* / Q000523:psychology; D001321:Autistic Disorder / Q000175:diagnosis* / Q000235:genetics* / Q000523:psychology; D002648:Child; D002659:Child Development Disorders, Pervasive / Q000175:diagnosis* / Q000235:genetics* / Q000523:psychology; D002675:Child, Preschool; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005163:Factor Analysis, Statistical; D005260:Female; D006801:Humans; D007223:Infant; D007406:Interview, Psychological; D008297:Male; D015233:Models, Statistical; D010552:Personality Assessment / Q000706:statistics & numerical data; D010641:Phenotype; D011594:Psychometrics / Q000706:statistics & numerical data; D015203:Reproducibility of Results; D035781:Siblings; D012931:Social Environment; D013223:Statistics as Topic