Microglial transplantation increases amyloid-beta clearance in Alzheimer model rats.
Immunization with amyloid-beta (Abeta) peptides, a therapeutic approach in Alzheimer's disease (AD), reduces brain Abeta, and microglial Abeta phagocytosis has been proposed as an Abeta-lowering mechanism. We transplanted rat microglia into the rat lateral ventricle just after intra-hippocampal Abeta injection, and then investigated the contribution of exogenous microglia to Abeta clearance. Migration of exogenous microglia from the lateral ventricle to Abeta plaque was detected by magnetic resonance imaging and histochemical analysis, and the clearance of Abeta was increased by transplantation. These results suggest the possible usefulness of exogenous microglia to the therapeutic approach in AD.
Takata
Kazuyuki
K
Department of Neurobiology and 21st Century COE Program, Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto 607-8414, Japan.
Kitamura
Yoshihisa
Y
Yanagisawa
Daijiro
D
Morikawa
Shigehiro
S
Morita
Masahito
M
Inubushi
Toshiro
T
Tsuchiya
Daiju
D
Chishiro
Saori
S
Saeki
Mana
M
Taniguchi
Takashi
T
Shimohama
Shun
S
Tooyama
Ikuo
I
D000544:Alzheimer Disease / Q000378:metabolism* / Q000473:pathology / Q000601:surgery*; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D000818:Animals; D016380:Brain Tissue Transplantation; D002465:Cell Movement; D004195:Disease Models, Animal; D006624:Hippocampus / Q000378:metabolism / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D017628:Microglia / Q000502:physiology / Q000637:transplantation*; D010587:Phagocytosis; D051381:Rats; D017208:Rats, Wistar; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D016229:Amyloid beta-Peptides; D014409:Tumor Necrosis Factor-alpha