title: Genomic signatures in non-small-cell lung cancer: targeting the targeted therapies.
abstract: Despite major developments in targeted biologic agents, patients with advanced non-small-cell lung cancer have a poor prognosis. Recent development of targeted biologic agents have given us insight into possibilities of matching therapy with disease; however, the success of these agents has been marginal. In this article, we discuss the use of genomic signatures that have been developed to identify unique aspects of individual lung tumors and provide insight on how novel strategies can be used to identify populations susceptible to specific targeted agents.
authors.affiliation: Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27708, USA. dress002@mc.duke.edu
authors.forename: Holly K
authors.initials: HK
authors.lastname: Dressman
authors.forename: Andrea
authors.initials: A
authors.lastname: Bild
authors.forename: Jennifer
authors.initials: J
authors.lastname: Garst
authors.forename: David
authors.initials: D
authors.lastname: Harpole
authors.forename: Anil
authors.initials: A
authors.lastname: Potti
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics* / Q000628:therapy; D020869:Gene Expression Profiling; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics* / Q000628:therapy; D009363:Neoplasm Proteins / Q000235:genetics*
chemical_list: D000970:Antineoplastic Agents; D009363:Neoplasm Proteins