Selecting a vasopressor drug for vasoplegic shock after adult cardiac surgery: a systematic literature review.
The choice of vasopressors to treat vasodilatory shock after cardiac surgery is a matter of controversy. We have systematically reviewed the literature and found that the data are insufficient to guide choice of agent. However, we found sufficient evidence that when a target blood pressure can not be achieved with a single agent, addition of another is more likely to help achieve the blood pressure target. We also found that there is no evidence that vasopressors induce organ ischemia. Finally, the lack of high quality data indicate that large multicenter trials are needed in this field.
Egi
Moritoki
M
Department of Intensive Care and Medicine, University of Melbourne, Austin Hospital, Heidelberg Victoria, Australia.
Bellomo
Rinaldo
R
Langenberg
Christoph
C
Haase
Michael
M
Haase
Anja
A
Doolan
Laurie
L
Matalanis
George
G
Seevenayagam
Siven
S
Buxton
Brian
B
D002315:Cardiopulmonary Bypass / Q000009:adverse effects*; D006801:Humans; D012769:Shock / Q000188:drug therapy* / Q000209:etiology*; D014662:Vasoconstrictor Agents / Q000627:therapeutic use*; D014664:Vasodilation
D014662:Vasoconstrictor Agents