title: Corneal melt associated with idiopathic dacryoadenitis.
abstract: A 15-year-old boy presented with left-sided ptosis, upper eyelid swelling, proptosis, conjunctivitis, and a central corneal epithelial defect with thinning. MRI demonstrated an enhancing orbital mass associated with the lacrimal gland. Biopsy findings were consistent with orbital inflammatory syndrome. Topical cyclosporine and 1% methylprednisolone eliminated the anterior segment inflammation; subsequent treatment with systemic prednisone reduced the ptosis and edema. To our knowledge, this is the only reported case of orbital inflammatory syndrome associated with a corneal epithelial defect and thinning.
authors.affiliation: Oculoplastics and Reconstructive Surgery, Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, Illinois 60612, USA.
authors.forename: Manishi A
authors.initials: MA
authors.lastname: Desai
authors.forename: Thasarat
authors.initials: T
authors.lastname: Vajaranant
authors.forename: Gregory
authors.initials: G
authors.lastname: Sulkowski
authors.forename: Elmer Y
authors.initials: EY
authors.lastname: Tu
authors.forename: James
authors.initials: J
authors.lastname: Kapustiak
authors.forename: John
authors.initials: J
authors.lastname: Pak
mesh_terms: D000293:Adolescent; D001763:Blepharoptosis / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology; D003231:Conjunctivitis / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology; D003316:Corneal Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D016572:Cyclosporine / Q000627:therapeutic use; D003607:Dacryocystitis / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D004359:Drug Therapy, Combination; D019573:Epithelium, Corneal / Q000187:drug effects / Q000473:pathology*; D005094:Exophthalmos / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008279:Magnetic Resonance Imaging; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use
chemical_list: D005938:Glucocorticoids; D007166:Immunosuppressive Agents; D016572:Cyclosporine; D008775:Methylprednisolone