title: Interleukin-1 genetic polymorphisms and their relationship to the cancer anorexia/weight loss syndrome in metastatic gastric and gastroesophageal junction adenocarcinoma.
abstract: Interleukin-1 (IL-1) beta is a putative mediator of the cancer anorexia/weight loss syndrome, and certain polymorphisms of its gene are thought to be associated with a greater risk of gastric cancer. Do these IL-1 beta genetic polymorphisms predispose patients with gastric and gastroesophageal cancer to the anorexia/weight loss syndrome? This study focused on 44 patients with metastatic gastric and gastroesophageal cancer. All underwent genotyping, completed serial quality-of-life questionnaires germane to appetite, and underwent meticulous serial follow-up. Patients with the IL-1 beta-31 C/T and T/T genotypes were more likely to describe a worse appetite at baseline than were those with the C/C genotype. In addition, patients with the IL-1 beta+3954 C/T and T/T genotypes showed greater improvements in their weight (P = 0.02) and in survival (hazard ratio, 0.3; P = 0.04) over time than did patients with the C/C genotype. These associations occurred independently of tumor response. These preliminary data suggest that certain interleukin-1 beta genetic polymorphisms may modulate the cancer anorexia/weight loss syndrome in patients with metastatic gastric and esophageal cancer. Confirmatory studies are warranted.
authors.affiliation: Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA. jatoi.aminah@mayo.edu
authors.forename: Aminah
authors.initials: A
authors.lastname: Jatoi
authors.forename: Phuong L
authors.initials: PL
authors.lastname: Nguyen
authors.forename: Nathan
authors.initials: N
authors.lastname: Foster
authors.forename: David
authors.initials: D
authors.lastname: Sun
authors.forename: Philip J
authors.initials: PJ
authors.lastname: Stella
authors.forename: Megan
authors.initials: M
authors.lastname: Campbell
authors.forename: Loren K
authors.initials: LK
authors.lastname: Tschetter
authors.forename: Shaker R
authors.initials: SR
authors.lastname: Dakhil
authors.forename: James A
authors.initials: JA
authors.lastname: Mailliard
authors.forename: Daniel A
authors.initials: DA
authors.lastname: Nikcevich
mesh_terms: D000230:Adenocarcinoma / Q000150:complications / Q000235:genetics* / Q000556:secondary; D000328:Adult; D000368:Aged; D000855:Anorexia / Q000235:genetics*; D004943:Esophagogastric Junction; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D053583:Interleukin-1beta / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011379:Prognosis; D011446:Prospective Studies; D011788:Quality of Life; D013274:Stomach Neoplasms / Q000150:complications / Q000235:genetics* / Q000473:pathology; D015996:Survival Rate; D013577:Syndrome; D015431:Weight Loss / Q000235:genetics*
chemical_list: D053583:Interleukin-1beta