Effect of valerian extract preparation (BIM) on the sleep-wake cycle in rats.
In the present study, we studied the effect of valerian extract preparation (BIM) containing valerian extract, golden root (Rhodiola rosea L.) extract and L-theanine (gamma-glutamylethylamide) on the sleep-wake cycle using sleep-disturbed model rats in comparison with that of valerian extract. A significant shortening in sleep latency was observed with valerian extract and the BIM at a dose of 1000 mg/kg. On the other hand, valerian extract and the BIM caused no significant effects on total times of wakefulness, non-rapid eye movement (non-REM) sleep and REM sleep. Valerian extract and the BIM at a dose of 1000 mg/kg also had no significant effect on delta activity. In conclusion, it became clear that the BIM could be useful as a herbal medicine having a sleep-inducing effect without causing an alteration of the sleep-wakefulness cycle.
Tokunaga
Shin
S
Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan.
Takeda
Yasuhiro
Y
Niimoto
Tsuyoshi
T
Nishida
Norihisa
N
Kubo
Toshihiro
T
Ohno
Tohru
T
Matsuura
Youichi
Y
Kawahara
Yuzo
Y
Shinomiya
Kazuaki
K
Kamei
Chiaki
C
D000818:Animals; D003700:Delta Rhythm / Q000187:drug effects; D004576:Electromyography; D005971:Glutamates / Q000494:pharmacology*; D006993:Hypnotics and Sedatives / Q000494:pharmacology*; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D029771:Rhodiola / Q000737:chemistry*; D012890:Sleep / Q000187:drug effects; D007319:Sleep Initiation and Maintenance Disorders / Q000188:drug therapy* / Q000503:physiopathology; D014632:Valerian / Q000737:chemistry*; D014851:Wakefulness / Q000187:drug effects
D005971:Glutamates; D006993:Hypnotics and Sedatives; D010936:Plant Extracts; C026166:theanine