title: [Sweet's syndrome associated with squamous cell bronchial carcinoma. Neutrophilic dermatosis and non-small cell lung cancer].
abstract: BACKGROUND
  Sweet's syndrome, one of the neutrophilic dermatoses, is idiopathic in most cases. In 10-20% of cases it is paraneoplastic, associated with a solid tumour or haematological malignancy. An association with carcinoma of the bronchus has been only rarely described.
  
  
  METHODS
  We report the case of a 56 year old man who presented with Sweet's syndrome two months before the diagnosis of a squamous cell carcinoma of the bronchus. The dermatosis responded well to corticosteroids. The progress of the tumour was favourable, with stabilisation following 3 courses of chemotherapy and local radiotherapy.
  
  
  CONCLUSIONS
  This case report updates this rare association and underlines the importance of undertaking appropriate thoracic investigations in the presence of this dermatosis. A paraneoplastic secretion of interleukin-8, GM-CSF and/or G-CSF by the bronchial tumour cells facilitating the recruitment of neutrophils, particularly in the skin, may account for the pathophysiology of this condition.
authors.affiliation: Service de Pneumologie, Centre Hospitalier Lyon Sud, HCL, France.
authors.forename: A
authors.initials: A
authors.lastname: Van Denhove
authors.forename: N
authors.initials: N
authors.lastname: Freymond
authors.forename: S
authors.initials: S
authors.lastname: Isaac
authors.forename: K
authors.initials: K
authors.lastname: Marrou
authors.forename: B
authors.initials: B
authors.lastname: Balme
authors.forename: F
authors.initials: F
authors.lastname: Gormand
authors.forename: B
authors.initials: B
authors.lastname: Guibert
authors.forename: Y
authors.initials: Y
authors.lastname: Pacheco
authors.forename: G
authors.initials: G
authors.lastname: Devouassoux
mesh_terms: D001984:Bronchial Neoplasms / Q000150:complications*; D002289:Carcinoma, Non-Small-Cell Lung / Q000150:complications*; D002294:Carcinoma, Squamous Cell / Q000150:complications*; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications*; D008297:Male; D008875:Middle Aged; D010257:Paraneoplastic Syndromes / Q000209:etiology*; D016463:Sweet Syndrome / Q000209:etiology*