Synthesis and evaluation as MRI probe of the trifluoromethylated p-boronophenylalanine and its alcohol derivative.
Boron-neutron capture therapy (BNCT) and magnetic resonance imaging (MRI) are quite attractive techniques for treatment and diagnosis of cancer, respectively. In order to develop practical tools for BNCT and MRI, novel compounds containing both the trifluoromethyl group and 10B atom in a single molecule were designed. In the present study, p-boronophenylalanine and p-boronophenylalaninol with the trifluoromethyl group were synthesized, and 19F NMR measurements of these compounds were carried out.
Hattori
Yoshihide
Y
Faculty of Science and Technology, Kinki University, Higashi-osaka, Osaka 577-8502, Japan.
Yamamoto
Hitoshi
H
Ando
Hideya
H
Kondoh
Hirofumi
H
Asano
Tomoyuki
T
Kirihata
Mitsunori
M
Yamaguchi
Yoshihiro
Y
Wakamiya
Tateaki
T
D000438:Alcohols / Q000737:chemistry*; D001896:Boron Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D015335:Molecular Probes; D010649:Phenylalanine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
D000438:Alcohols; D001896:Boron Compounds; D015335:Molecular Probes; D010649:Phenylalanine; C033685:4-boronophenylalanine