title: Infection with a novel gammaherpesvirus in northern elephant seals (Mirounga angustirostris).
abstract: Twenty juvenile northern elephant seals (Mirounga angustirostris) that died between 1998 and 2004 had ulcers on the tongue, palatine mucosa, and/or tonsils. Histologic examination of the lesions revealed cytoplasmic swelling, nuclear pyknosis, and eosinophilic to amphophilic intranuclear inclusions bodies suggestive of herpesviral infection. Electron microscopic examination and polymerase chain reaction analysis confirmed the presence of a herpesvirus. Subsequent DNA sequencing identified this to be a new gammaherpesvirus that was similar to Porcine lymphotropic virus 2, Alcephaline herpesvirus 1 (malignant catarrhal fever virus from wildebeest), and Chlorocebus rhadinovirus 1 from African green monkeys. Identical herpesviral DNA was also detected in blood and mucosal swabs collected from five healthy elephant seal pups.
authors.affiliation: The Marine Mammal Center, 1065 Fort Cronkhite, Sausalito, California 94965, USA. goldsteint@tmmc.org
authors.forename: Tracey
authors.initials: T
authors.lastname: Goldstein
authors.forename: Linda J
authors.initials: LJ
authors.lastname: Lowenstine
authors.forename: Thomas P
authors.initials: TP
authors.lastname: Lipscomb
authors.forename: Jonna A K
authors.initials: JA
authors.lastname: Mazet
authors.forename: Joseph
authors.initials: J
authors.lastname: Novak
authors.forename: Jeffrey L
authors.initials: JL
authors.lastname: Stott
authors.forename: Frances M D
authors.initials: FM
authors.lastname: Gulland
mesh_terms: D000818:Animals; D000831:Animals, Newborn / Q000821:virology; D000835:Animals, Wild / Q000821:virology; D004279:DNA, Viral / Q000032:analysis*; D017809:Fatal Outcome; D006564:Herpesviridae / Q000145:classification / Q000302:isolation & purification*; D006566:Herpesviridae Infections / Q000453:epidemiology / Q000473:pathology / Q000662:veterinary*; D010802:Phylogeny; D016133:Polymerase Chain Reaction / Q000662:veterinary; D046048:Seals, Earless / Q000821:virology*
chemical_list: D004279:DNA, Viral