Optoacoustic imaging of absorbing objects in a turbid medium: ultimate sensitivity and application to breast cancer diagnostics.
One of the major medical applications of optoacoustic (OA) tomography is in the diagnostics of early-stage breast cancer. A numerical approach was developed to characterize the following parameters of an OA imaging system: resolution, maximum depth at which the tumor can be detected, and image contrast. The parameters of the 64-element focused array transducer were obtained. The results of numerical modeling were compared with known analytical solutions and further validated by phantom experiments. The OA images of a 3 mm piece of bovine liver immersed in diluted milk at various depths were obtained. Based on the results of modeling, a signal filtering algorithm for OA image contrast enhancement has been proposed.
Khokhlova
Tatiana D
TD
Faculty of Physics, Moscow State University, Moscow, Russia. t_hokhlova@ilc.edu.ru
Pelivanov
Ivan M
IM
Kozhushko
Victor V
VV
Zharinov
Alexei N
AN
Solomatin
Vladimir S
VS
Karabutov
Alexander A
AA
D000162:Acoustics; D000465:Algorithms; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000473:pathology; D003198:Computer Simulation; D006801:Humans; D007089:Image Enhancement; D015233:Models, Statistical; D008962:Models, Theoretical; D055095:Optics and Photonics; D012680:Sensitivity and Specificity; D012984:Software; D014054:Tomography / Q000379:methods*