Revised structures of gambiriins A1, A2, B1, and B2, chalcane-flavan dimers from gambir (Uncaria gambir extract).
Gambir, the aqueous extract from Uncaria gambir (Rubiaceae), has been used as an astringent medicine in Asian countries. Investigation of the constituents in the extract led to the isolation of four chalcane-flavan dimers, gambiriin A1 (6), A2 (7), B1 (8), and B2 (9), in addition to (+)-catechin (1), (+)-epicatechin (2), and dimeric proanthocyanidins, procyanidin B1 (3), procyanidin B3 (4), and gambiriin C (5). The spectroscopic and chemical data obtained in the present study indicated that their previously proposed structures 6a, 7a, 8a, and 9a should be revised to 6, 7, 8, and 9, respectively.
Taniguchi
Shoko
S
Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
Kuroda
Kayo
K
Doi
Kou-ichi
K
Tanabe
Masahiro
M
Shibata
Takashi
T
Yoshida
Takashi
T
Hatano
Tsutomu
T
D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification; D000975:Antioxidants / Q000737:chemistry* / Q000302:isolation & purification; D044946:Biflavonoids / Q000737:chemistry / Q000302:isolation & purification; D002392:Catechin / Q000737:chemistry / Q000302:isolation & purification; D002599:Chalcone / Q000031:analogs & derivatives* / Q000302:isolation & purification; D019281:Dimerization; D005419:Flavonoids / Q000737:chemistry* / Q000302:isolation & purification; D007211:Indoles / Q000737:chemistry* / Q000302:isolation & purification; D010936:Plant Extracts / Q000737:chemistry*; D010946:Plants, Medicinal; D044945:Proanthocyanidins / Q000737:chemistry / Q000302:isolation & purification; D019666:Rubiaceae / Q000737:chemistry*; D013057:Spectrum Analysis
D000470:Alkaloids; D000975:Antioxidants; D044946:Biflavonoids; D005419:Flavonoids; D007211:Indoles; D010936:Plant Extracts; D044945:Proanthocyanidins; C479579:procyanidin B1; C077749:gambirine; C479581:procyanidin B3; D002599:Chalcone; D002392:Catechin