Acetaminophen use and the symptoms of asthma, allergic rhinitis and eczema in children.
Allergic diseases are frequent in children and their prevalence and severity differ in the different regions of the world. A number of studies have been performed to determine the factors which are effective in the incidence of these diseases. One of the drugs that might have a role in incidence or intensity of the symptoms of allergic diseases is Acetaminophen. In our survey conducted with standardized method (International Study of Asthma and Allergies in Childhood), 3000 children 6-7 years old and 3000 teenagers 13-14 years old were questioned regarding asthma, allergic rhinitis and eczema. The prevalence of ever wheezing in the children of 6-7 years old who took acetaminophen in the first year of their life was 11.3%, which is more than other group (Odds Ratio=1.54, 95% Confidence Interval: 1-2.38, P=0.049) and the prevalence of ever wheezing in older age group who have taken acetaminophen at least once in a month was 25.1% which is more than those taken less acetaminophen (OR=1.7, 95%CI=1.43-2.04, P=0.000). Moreover taking more acetaminophen during past 12 months led to more prevalence of night dry coughs and the symptoms of rhinitis in children 6-7 years old and eczema and rhinitis symptoms in the 13-14 years old. Our findings suggest that taking more acetaminophen may be associated with increasing allergic symptoms in children.
Karimi
Mehran
M
Department of Pediatrics, School of Medicine, Shahid Sadoughi University Of Medical Sciences and Health Services, Yazd, Iran. mehrankarimi1@hotmail.com
Mirzaei
Mohsen
M
Ahmadieh
Mohammad Hossein
MH
D000082:Acetaminophen / Q000009:adverse effects*; D000293:Adolescent; D018712:Analgesics, Non-Narcotic / Q000009:adverse effects*; D001249:Asthma / Q000453:epidemiology*; D002648:Child; D004305:Dose-Response Relationship, Drug; D004485:Eczema / Q000139:chemically induced / Q000453:epidemiology* / Q000473:pathology; D006801:Humans; D012221:Rhinitis, Allergic, Perennial / Q000139:chemically induced / Q000453:epidemiology* / Q000473:pathology; D006255:Rhinitis, Allergic, Seasonal / Q000139:chemically induced / Q000453:epidemiology* / Q000473:pathology; D012307:Risk Factors
D018712:Analgesics, Non-Narcotic; D000082:Acetaminophen