title: [Expression and clinical significance of focal adhesion kinase in oral squamous cell carcinoma].
abstract: OBJECTIVE
  To study the correlation between expression levels of focal adhesion kinase (FAK) in oral squamous cell carcinoma (OSCC) and clinical prognosis with pathologic parameters.
  
  
  METHODS
  Eighty paraffin embedded tissue specimens of OSCC were studied by immunohistochemistry. The data was analyzed by SPSS statistical software.
  
  
  RESULTS
  FAK was highly expressed in OSCC tissues, in contrast to none or a low expression in normal oral epithelial tissue, and the heterogeneous staining was mainly located in the cell membrane and cytoplasm. FAK overexpression significantly correlated with histological differentiation and TNM stage, lymphatic metastasis. Multivariate analysis revealed that overexpression of FAK was the independent prognostic factor.
  
  
  CONCLUSIONS
  The overexpression of FAK in the peripheral area of OSCC may serve as a useful biological factor affecting prognosis.
authors.affiliation: Department of Pathology, West China Stomatology Hospital, Sichuan University, Chengdu 610041, China.
authors.forename: Zhi-Xiu
authors.initials: ZX
authors.lastname: He
authors.forename: Hua-Wei
authors.initials: HW
authors.lastname: He
authors.forename: Dan
authors.initials: D
authors.lastname: Wang
authors.forename: Mei-Xian
authors.initials: MX
authors.lastname: Fang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D005260:Female; D051416:Focal Adhesion Protein-Tyrosine Kinases / Q000378:metabolism*; D005500:Follow-Up Studies; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D011379:Prognosis; D012044:Regression Analysis; D055815:Young Adult
chemical_list: D051416:Focal Adhesion Protein-Tyrosine Kinases