title: Outcomes of morbidly obese patients requiring mechanical ventilation for acute respiratory failure.
abstract: OBJECTIVE
  To examine the outcomes of morbidly obese patients with acute respiratory failure treated with mechanical ventilation.
  
  
  METHODS
  Retrospective study.
  
  
  METHODS
  A 14-bed medical intensive care unit in an 800-bed university-based hospital.
  
  
  METHODS
  A total of 50 morbidly obese subjects with acute respiratory failure requiring ventilatory assistance.
  
  
  METHODS
  None.
  
  
  METHODS
  Arterial blood gas measurements, intubation rate, days of mechanical ventilation, intensive care unit length of stay, hospital length of stay, and mortality.
  
  
  RESULTS
  From January 1997 to December 2004, 50 morbidly obese patients with acute respiratory failure were treated with mechanical ventilation. Invasive mechanical ventilation was implemented in 17 patients with a mean body mass index of 53.2 +/- 12.2 kg/m2. A total of 33 patients were treated with noninvasive ventilation (NIV), of which 21 avoided intubation (NIV success) and 12 required intubation (NIV failure). Mean body mass index for the NIV success group was significantly less than for the NIV failure group (46.9 +/- 8.9 and 62.5 +/- 16.1 kg/m2, respectively, p = .001). Acute Physiology and Chronic Health Evaluation II scores were similar for patients treated with invasive and noninvasive ventilation. Significant improvements in pH and Paco2 were noted for the invasive mechanical ventilation and NIV success groups. No improvements in gas exchange were noted in the NIV failure group. Of patients treated with NIV, 36% required intubation. Hospital mortality for the invasive ventilation and NIV failure groups was increased.
  
  
  CONCLUSIONS
  The type of ventilatory assistance may influence clinical outcomes in morbidly obese patients with acute respiratory failure.
authors.affiliation: Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX, USA.
authors.forename: Alexander G
authors.initials: AG
authors.lastname: Duarte
authors.forename: Edmundo
authors.initials: E
authors.lastname: Justino
authors.forename: Teresa
authors.initials: T
authors.lastname: Bigler
authors.forename: James
authors.initials: J
authors.lastname: Grady
mesh_terms: D018806:APACHE; D000328:Adult; D000368:Aged; D001784:Blood Gas Analysis; D015992:Body Mass Index; D045422:Continuous Positive Airway Pressure; D005260:Female; D017052:Hospital Mortality; D006785:Hospitals, University; D006801:Humans; D007362:Intensive Care Units; D007442:Intubation, Intratracheal; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D009767:Obesity, Morbid / Q000503:physiopathology*; D011175:Positive-Pressure Respiration; D012121:Respiration, Artificial; D012128:Respiratory Distress Syndrome / Q000401:mortality / Q000503:physiopathology / Q000628:therapy*; D012189:Retrospective Studies; D017211:Treatment Failure; D016896:Treatment Outcome