Anti-mycobacterial activity of a bis-sulfonamide.
A bis-arylsulfonamide, 7, has been identified that exhibits growth inhibition of Mycobacterium smegmatis at less than 25 microg/mL, but has no such activity against Escherichia coli or Staphylococcus aureus. A closely related bis-arylsulfonamide (8) was much less active, but was the only other compound among 54 arylsulfonamides tested with detectable growth inhibition of M. smegmatis.
Wilkinson
Brendan L
BL
Eskitis Institute for Cell and Molecular Therapies, Griffith University, Nathan, Qld 4111, Australia.
Bornaghi
Laurent F
LF
Wright
Anthony D
AD
Houston
Todd A
TA
Poulsen
Sally-Ann
SA
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects; D020102:Mycobacterium smegmatis / Q000187:drug effects*; D013211:Staphylococcus aureus / Q000187:drug effects; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D013449:Sulfonamides