title: Differences in the diagnostic value of various criteria of negative T waves for hypertrophic cardiomyopathy based on a molecular genetic diagnosis.
abstract: Differences in the diagnostic value of a variety of definitions of negative T waves for HCM (hypertrophic cardiomyopathy) have not yet been clarified, resulting in a number of definitions being applied in previous studies. The aim of the present study was to determine the most accurate diagnostic definition of negative T waves for HCM in genotyped populations. Electrocardiographic and echocardiographic findings were analysed in 161 genotyped subjects (97 carriers and 64 non-carriers). We applied three different criteria that have been used in previous studies: Criterion 1, negative T wave >10 mm in depth in any leads; Criterion 2, negative T wave >3 mm in depth in at least two leads; and Criterion 3, negative T wave >1 mm in depth in at least two leads. Of the three criteria, Criterion 3 had the highest sensitivity (43% compared with 5 and 26% in Criterion 1 and Criterion 2 respectively; P<0.0001) and retained a specificity of 95%, resulting in the highest accuracy. In comparison with abnormal Q waves, negative T waves for Criterion 3 had a lower sensitivity in detecting carriers without LVH (left ventricular hypertrophy) (12.9% for negative T waves compared with 22.6% for abnormal Q waves). On the other hand, in detecting carriers with LVH, the sensitivity of negative T waves increased in a stepwise direction with the increasing extent of LVH (P<0.001), whereas there was less association between the sensitivity of abnormal Q waves and the extent of LVH. In conclusion, Criterion 3 for negative T waves may be the most accurate definition of HCM based on genetic diagnoses. Negative T waves may show different diagnostic value according to the different criteria and phenotypes in genotyped populations with HCM.
authors.affiliation: Department of Internal Medicine, Division of Cardiovascular Medicine, Kanazawa University Graduate School of Medical Science, Takara-machi, Kanazawa, Japan.
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Konno
authors.forename: Noboru
authors.initials: N
authors.lastname: Fujino
authors.forename: Kenshi
authors.initials: K
authors.lastname: Hayashi
authors.forename: Katsuharu
authors.initials: K
authors.lastname: Uchiyama
authors.forename: Eiichi
authors.initials: E
authors.lastname: Masuta
authors.forename: Hiromasa
authors.initials: H
authors.lastname: Katoh
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Sakamoto
authors.forename: Toshinari
authors.initials: T
authors.lastname: Tsubokawa
authors.forename: Hidekazu
authors.initials: H
authors.lastname: Ino
authors.forename: Masakazu
authors.initials: M
authors.lastname: Yamagishi
mesh_terms: D000328:Adult; D002312:Cardiomyopathy, Hypertrophic / Q000175:diagnosis* / Q000235:genetics; D004562:Electrocardiography / Q000592:standards*; D005260:Female; D006580:Genetic Carrier Screening / Q000379:methods; D006801:Humans; D008297:Male; D009154:Mutation / Q000235:genetics; D010375:Pedigree; D012680:Sensitivity and Specificity