title: An efficient highly regioselective synthesis of 2,3,4-trisubstituted pyrroles by cycloaddition of polarized ketene S,S- and N,S-acetals with activated methylene isocyanides.
abstract: An efficient route for regioselective synthesis of 2,3,4- substituted pyrroles allowing precise control over the introduction of a number of substituents and functionalities (tosyl, carbalkoxy, aryl, cyano, nitro, acetyl, benzoyl, cyclic amines, etc.) at the three positions of the pyrrole ring has been developed via 1,3-dipolar cycloaddition of readily accessible polarized ketene S,S- and N,S-acetals with carbanions derived from activated methylene isocyanides.
authors.affiliation: Department of Chemistry, Indian Institute of Technology, Kanpur-208016, India.
authors.forename: N C
authors.initials: NC
authors.lastname: Misra
authors.forename: K
authors.initials: K
authors.lastname: Panda
authors.forename: H
authors.initials: H
authors.lastname: Ila
authors.forename: H
authors.initials: H
authors.lastname: Junjappa