Two-dimensional arrays of amphiphilic Zn2+-cyclens for guided molecular recognition at interfaces.
The sterically guided molecular recognition of nucleobases, phosphates, adenosine, and uridine nucleotides on Langmuir monolayers and Langmuir-Blodgett monolayers of amphiphilic mono- or bis(Zn2+-cyclen)s assembled on thiolated surfaces was investigated. The stepwise selective binding of metal ions, uracil, or phosphate by dicetyl cyclen monolayers with variously tuned structures at the air/water interface was corroborated by the measurements of the corresponding LB films deposited onto quartz crystals. Two types of recognition surfaces were fabricated from Zn2+-dicetyl cyclen. The surface covered with a complex preformed in the Langmuir monolayer was capable both of imide and of phosphate binding. The similar complex formed directly in an LB film on thiolated gold was inactive with respect to imide. The surface plasmon resonance measurements evidenced the stepwise assembly of complementary nucleotides on SAM/LB templates through consecutive phosphate-Zn2+-cyclen coordination. Base pairing between nucleotides resulted in a formation of A-U bilayers comprising two complementary monolayers. Finally, we report on SAM/LB patterns designed for divalent molecular recognition of uridine phosphate by amphiphilic bis(Zn2+-cyclen).
Turygin
Dmitry S
DS
Department of Physical Chemistry of Supramolecular Systems, Frumkin Institute of Physical Chemistry and Electrochemistry RAS, 31 Leninsky Prospect, Moscow 119991, Russia.
Subat
Michael
M
Raitman
Oleg A
OA
Selector
Sofia L
SL
Arslanov
Vladimir V
VV
König
Burkhard
B
Kalinina
Maria A
MA
D000327:Adsorption; D002627:Chemistry, Physical / Q000379:methods*; D003460:Crystallization; D007477:Ions; D008956:Models, Chemical; D009711:Nucleotides / Q000737:chemistry; D010710:Phosphates / Q000737:chemistry; D011312:Pressure; D011791:Quartz; D013438:Sulfhydryl Compounds; D020349:Surface Plasmon Resonance; D013499:Surface Properties; D013997:Time Factors; D014500:Uracil Nucleotides / Q000737:chemistry*; D015032:Zinc / Q000737:chemistry*
D007477:Ions; D009711:Nucleotides; D010710:Phosphates; D013438:Sulfhydryl Compounds; D014500:Uracil Nucleotides; D011791:Quartz; D015032:Zinc