title: [Prolonged complete remission of multiple organ metastases after radical nephrectomy induced by interferon-alpha therapy: a case report].
abstract: We experienced a case of advanced renal carcinoma that showed complete remission to interferon-alpha therapy. A 76-year-old male underwent radical nephrectomy for left renal cell carcinoma (pT3b pN0 M0, stage III). Two and a half months later, chest X-ray, computed tomographic (CT) scan and ultrasonography revealed multiple lung metastases and a hepatic metastasis simultaneously. We started the intramuscular administration of natural interferon-alpha (OIF, 5 MIU) combined with cimetidine everyday. It caused leukopenia, a possible side-effect of interferon-alpha. We reduced the dose to three times a week. The lung metastases and hepatic metastases disappeared after 5 and 12 months, respectively. After we reduced the dose to once a week, there was no evidence of disease for 21 months.
authors.affiliation: Department of Urology, Shakaihoken Chukyo Hospital.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Hirano
authors.forename: Takashi
authors.initials: T
authors.lastname: Fujita
authors.forename: Toru
authors.initials: T
authors.lastname: Kimura
authors.forename: Masashi
authors.initials: M
authors.lastname: Katoh
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Tsuji
authors.forename: Tsuneo
authors.initials: T
authors.lastname: Kinukawa
authors.forename: Yoshikatsu
authors.initials: Y
authors.lastname: Nojiri
mesh_terms: D000368:Aged; D002292:Carcinoma, Renal Cell / Q000473:pathology / Q000628:therapy*; D006801:Humans; D016898:Interferon-alpha / Q000627:therapeutic use*; D007680:Kidney Neoplasms / Q000473:pathology / Q000628:therapy*; D008113:Liver Neoplasms / Q000188:drug therapy / Q000556:secondary*; D008175:Lung Neoplasms / Q000188:drug therapy / Q000556:secondary*; D008297:Male; D009392:Nephrectomy; D012074:Remission Induction / Q000379:methods
chemical_list: D016898:Interferon-alpha