One-step synthesis of alpha-chloro acetophenones from acid chlorides and aryl precursors.
A direct and efficient method was developed for the preparation of a variety of substituted acetophenone derivatives from readily available arene precursors and acid chlorides. This method has significant generality and affords access to substitution patterns on aryl rings not directly achievable by Friedel-Crafts chemistry. [reaction: see text].
Rosen
Jonathan
J
Merck & Company, Inc., Department of Process Research, P.O. Box 2000, Rahway, New Jersey 07065, USA. jonathan_rosen@merck.com
Steinhuebel
Dietrich
D
Palucki
Michael
M
Davies
Ian
I
D000098:Acetophenones / Q000138:chemical synthesis*; D000215:Acylation; D002384:Catalysis; D002712:Chlorides / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D003300:Copper / Q000737:chemistry; D017967:Zinc Compounds / Q000737:chemistry
D000098:Acetophenones; D002712:Chlorides; D017967:Zinc Compounds; D003300:Copper; C016837:zinc chloride