Copper-catalyzed double N-alkenylation of amides: an efficient synthesis of di- or trisubstituted N-acylpyrroles.
An efficient copper-catalyzed double alkenylation of amides with (1Z,3Z)-1,4-diiodo-1,3-dienes is reported for the first time. The reactions proceed to afford di- or trisubstituted N-acylpyrroles in good to excellent yields using CuI as the catalyst, Cs2CO3 as the base, and rac-trans-N,N'-dimethylcyclohexane-1,2-diamine as the ligand.
Yuan
Xiyuan
X
Department of Chemistry and Shanghai Key Laboratory of Green Chemistry and Chemical Processes, East China Normal University, 3663 North Zhongshan Road, Shanghai 200062, P. R. China.
Xu
Xiaobing
X
Zhou
Xiaobo
X
Yuan
Jiwei
J
Mai
Lugen
L
Li
Yanzhong
Y