title: [Adenosine for treatment of ischemic pain in thromboangiitis obliterans. A case report].
abstract: Treating ischemic pain is often unsatisfactory. Current findings demonstrate that patients with chronic ischemia may develop sensory neuropathy and signs of central sensitization. This issue makes is reasonable treating with conventional analgesics and drugs against neuropathic pain. Adenosine has also a pain reducing effect in neuropathic pain which makes it a possible therapeutic option in ischemic pain.We report of a patient with thromboangiitis obliterans. We treated his pain with a broad analgesic therapy and administered adenosine intravenously, which resulted in a reduction of pain for several hours. Afterwards the patient received buflomedil to increase adenosine plasma levels. A long term pain reduction could be achieved. Modulation of adenosine demonstrates an experimental approach in the therapy of ischemic pain in thromboangiitis obliterans.
authors.affiliation: Interdisziplinäre Schmerzambulanz, Klinik für Anästhesiologieder Ludwig-Maximilians-Universität München, Klinikum Innenstadt, München. philip.lang@med.uni-muenchen.de
authors.forename: Philip M
authors.initials: PM
authors.lastname: Lang
authors.forename: D
authors.initials: D
authors.lastname: Irnich
mesh_terms: D000241:Adenosine / Q000627:therapeutic use*; D000328:Adult; D000700:Analgesics / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007511:Ischemia / Q000209:etiology / Q000503:physiopathology*; D010146:Pain / Q000188:drug therapy* / Q000209:etiology; D010147:Pain Measurement; D013919:Thromboangiitis Obliterans / Q000503:physiopathology*; D016896:Treatment Outcome
chemical_list: D000700:Analgesics; D000241:Adenosine