Micafungin activity against Candida bloodstream isolates: effect of growth medium and susceptibility testing method.
An excellent correlation between micafungin MICs were demonstrated against Candida bloodstream isolates (n = 200) by the Sensititre YeastOne and National Committee for Clinical Laboratory Standards M27-A2 methods. Use of antibiotic medium 3 (2%) dextrose improved micafungin activity and was not associated with paradoxical growth as noted with 3 Candida isolates tested using RPMI (2%) dextrose.
Pai
Manjunath P
MP
University of New Mexico Health Sciences Center, College of Pharmacy, MSC09 5360, Albuquerque, NM 87131-0001, USA. apai@salud.unm.edu
Jones
Ariel L
AL
Mullen
Casey K
CK
D000935:Antifungal Agents / Q000494:pharmacology*; D001769:Blood / Q000382:microbiology*; D002175:Candida / Q000187:drug effects* / Q000254:growth & development / Q000302:isolation & purification; D002177:Candidiasis / Q000382:microbiology; D003470:Culture Media / Q000737:chemistry*; D054714:Echinocandins; D016469:Fungemia / Q000382:microbiology*; D005947:Glucose; D006801:Humans; D055666:Lipopeptides; D008074:Lipoproteins / Q000494:pharmacology*; D000077551:Micafungin; D008826:Microbial Sensitivity Tests / Q000379:methods / Q000592:standards; D010456:Peptides, Cyclic / Q000494:pharmacology*
D000935:Antifungal Agents; D003470:Culture Media; D054714:Echinocandins; D055666:Lipopeptides; D008074:Lipoproteins; D010456:Peptides, Cyclic; D005947:Glucose; D000077551:Micafungin