title: Bienzymatic supramolecular complex of catalase modified with cyclodextrin-branched carboxymethylcellulose and superoxide dismutase: stability and anti-inflammatory properties.
abstract: A bienzymatic supramolecular assembly of CAT and SOD is reported. CAT was chemically glycosilated with CD branched CMC and then associated with SOD modified with 1-adamantane carboxylic acid. SOD was remarkably resistant to inactivation by H(2)O(2) and its anti-inflammatory activity was 4.5-fold increased after supramolecular association with the modified CAT form. [structure: see text]
authors.affiliation: Center for Enzyme Technology, University of Matanzas, Autopista a Varadero km 3 1/2, Matanzas, C. P. 44740, Cuba.
authors.forename: Aymara
authors.initials: A
authors.lastname: Valdivia
authors.forename: Yunel
authors.initials: Y
authors.lastname: Pérez
authors.forename: Roberto
authors.initials: R
authors.lastname: Cao
authors.forename: Maysa
authors.initials: M
authors.lastname: Baños
authors.forename: Ariel
authors.initials: A
authors.lastname: García
authors.forename: Reynaldo
authors.initials: R
authors.lastname: Villalonga
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry*; D002236:Carbohydrate Conformation; D002351:Carrageenan; D002374:Catalase / Q000097:blood / Q000737:chemistry*; D002417:Cattle; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D004912:Erythrocytes / Q000201:enzymology; D006031:Glycosylation; D006861:Hydrogen Peroxide / Q000378:metabolism; D007700:Kinetics; D046911:Macromolecular Substances; D008297:Male; D008958:Models, Molecular; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000097:blood / Q000737:chemistry*
chemical_list: D000893:Anti-Inflammatory Agents; D046911:Macromolecular Substances; D002351:Carrageenan; D006861:Hydrogen Peroxide; D002374:Catalase; D013482:Superoxide Dismutase