Approaches towards enhanced transepithelial drug delivery.
The systemic absorption of drugs is limited by their physicochemical properties and by physiological processes. Intense research efforts have been directed towards the development of novel strategies for enhancing systemic absorption of poorly absorbed molecules, administered orally or by other noninvasive routes. This article discusses some of these absorption enhancement strategies with respect to intestinal and other transmucosal drug delivery routes.
Majumdar
Soumyajit
S
Department of Pharmaceutics, School of Pharmacy, The University of Mississippi, MS 38677, USA.
Mitra
Ashim K
AK
D000818:Animals; D004333:Drug Administration Routes; D004337:Drug Carriers / Q000008:administration & dosage* / Q000737:chemistry; D016503:Drug Delivery Systems / Q000379:methods*; D004848:Epithelium / Q000378:metabolism*; D006801:Humans; D010455:Peptides / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics; D004364:Pharmaceutical Preparations / Q000008:administration & dosage* / Q000737:chemistry; D011355:Prodrugs / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics; D011506:Proteins / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics
D004337:Drug Carriers; D010455:Peptides; D004364:Pharmaceutical Preparations; D011355:Prodrugs; D011506:Proteins