title: Oligogenic transmission of abnormal teat patterning phenotype (ATPP) in cattle.
abstract: Abnormal teat patterning phenotype (ATPP) is characterized by one (moderate form) or two (severe form) absent teats in cattle. Using an allele-sharing non-parametric linkage strategy, significant associations with severe ATPP animals were detected on BTA17 (Z(max) = 7.3 at 21 cM), centromeric BTA1 (Z(max) = 3.7 at 8 cM) and telomeric BTA1 (Z(max) = 4.8 at 142 cM). The BTA17 region was also significantly associated in the analysis of the moderate ATPP animals (Z(max) = 5.3 at 0 cM). The transmission disequilibrium test in severe ATPP animals demonstrated significant over-transmission of paternal alleles in the BTA17 region (P = 2.2 x 10(-9)), the centromeric BTA1 region (P = 0.035) and the telomeric BTA1 region (P = 0.005). Significant over-transmission of the BTA17 region was also observed among the moderate ATPP animals (P = 2.3 x 10(-4)). These findings indicate that the BTA17 locus plays a key role in risk of the disease, and that the BTA17 locus contributes temporally in combination with the two other loci on BTA1 and/or possibly unknown modifier(s) in a probabilistic oligo- or polygenic manner of transmission. Haplotypes of these three loci can be used for marker-assisted animal breeding to control the recurrence of affected progeny with ATPP.
authors.affiliation: Shirakawa Institute of Animal Genetics, Odakura, Nishigo, Fukushima 961-8061, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Ihara
authors.forename: T
authors.initials: T
authors.lastname: Watanabe
authors.forename: Y
authors.initials: Y
authors.lastname: Sato
authors.forename: T
authors.initials: T
authors.lastname: Itoh
authors.forename: T
authors.initials: T
authors.lastname: Suzuki
authors.forename: Y
authors.initials: Y
authors.lastname: Sugimoto
mesh_terms: D000483:Alleles; D000818:Animals; D019521:Body Patterning / Q000235:genetics; D002417:Cattle / Q000002:abnormalities* / Q000235:genetics*; D002418:Cattle Diseases / Q000235:genetics; D005260:Female; D050173:Genes, Y-Linked; D008040:Genetic Linkage; D006239:Haplotypes; D008297:Male; D008321:Mammary Glands, Animal / Q000002:abnormalities*; D020412:Multifactorial Inheritance; D010641:Phenotype