title: Lack of experience of intravenous thrombolysis for acute ischaemic stroke does not influence the proportion of patients treated.
abstract: OBJECTIVE
  To determine the eligibility of patients with ischaemic stroke admitted to the 2nd Department of Neurology, Institute of Psychiatry and Neurology, Warsaw, Poland, for intravenous thrombolysis; to identify the major exclusions and assess whether organisational changes in the in-hospital stroke pathway and informative campaign in the local community and medical services can increase the number of patients treated; and to establish whether lack of previous experience with thrombolytic treatment or trials is predictive of the low proportion of patients treated.
  
  
  METHODS
  A survey of the database of patients with stroke admitted during the first 30 months after the introduction of intravenous thrombolysis for acute ischaemic stroke was conducted to search for all eligible patients. This included patients admitted within 2 h of symptom onset (assuming a 1 h door-to-needle time), age <80 years, National Institute of Health Stroke Scale (NIHSS) Score of 5-22, seizures at onset, platelet count >100,000/ml, glycaemia 50-400 mg/dl and international normalised ratio (INR) <1.6. The number of eligible patients was compared with the number actually treated.
  
  
  RESULTS
  745 patients with acute ischaemic stroke were admitted during the study period. 18.4% were admitted within 2 h of symptom onset, 71% were aged <80 years, 55.4% had an NIHSS score between 5 and 22, 96.1% had INR <1.6, 98.9% had a platelet count >100,000/ml, 99.4% had blood glucose concentrations of 50-400 mg/dl and 97.4% had no seizures at onset. After adjusting for all inclusion criteria, 7.1% of the patients were found to be potentially eligible and 8.7% were actually treated (p = 0.25). Of the 65 treated patients, 63.1% were independent after 3 months, 16.9% died and none had a symptomatic intracranial haemorrhage.
  
  
  CONCLUSIONS
  The proportion of patients with ischaemic stroke treated with intravenous thrombolysis in a previously inexperienced centre was not lower than in other centres and in countries where this treatment has been provided for a longer period of time. The number of patients treated was higher than that estimated mainly owing to organisational changes introduced in our centre, allowing treatment of those admitted between 2 and 3 h after symptom onset.
authors.affiliation: Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Poland. akobayas@amwaw.edu.pl
authors.forename: Adam
authors.initials: A
authors.lastname: Kobayashi
authors.forename: Marta
authors.initials: M
authors.lastname: Skowronska
authors.forename: Tomasz
authors.initials: T
authors.lastname: Litwin
authors.forename: Anna
authors.initials: A
authors.lastname: Czlonkowska
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002545:Brain Ischemia / Q000150:complications / Q000188:drug therapy*; D019091:Critical Pathways; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D019983:Guideline Adherence / Q000706:statistics & numerical data*; D019538:Health Care Surveys; D006801:Humans; D007262:Infusions, Intravenous; D009462:Neurology / Q000458:organization & administration / Q000706:statistics & numerical data; D012042:Registries; D020521:Stroke / Q000188:drug therapy*; D015912:Thrombolytic Therapy / Q000706:statistics & numerical data*; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use*
chemical_list: D005343:Fibrinolytic Agents; D010959:Tissue Plasminogen Activator