Successful treatment of vulvar lichen sclerosus in a child with low-concentration topical tacrolimus ointment.
Lichen sclerosus is a chronic inflammatory skin disorder that has a predilection for the anogenital area. Topical corticosteroid is occasionally effective; however, continuous treatment is often required and recurrence after its stoppage is frequent. Herein, we report a case of vulvar lichen sclerosus in a 5-year-old girl, which was refractory to topical corticosteroids. After 14 weeks of treatment with 0.03% tacrolimus ointment once daily, the lesions completely resolved without side-effects. Of interest, the number of milia within the plaque of lichen sclerosus was reduced in tandem with the improvement of lichen sclerosus. This is the first report of topical low-concentration tacrolimus treatment showing a dramatic effect in the treatment of childhood vulvar lichen sclerosus.
Matsumoto
Yuka
Y
Department of Dermatology, Tokyo Medical University, Tokyo, Japan.
Yamamoto
Toshiyuki
T
Isobe
Tamaki
T
Kusunoki
Toshio
T
Tsuboi
Ryoji
R
D000287:Administration, Topical; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage*; D009824:Ointments; D016559:Tacrolimus / Q000008:administration & dosage*; D007724:Vulvar Lichen Sclerosus / Q000188:drug therapy* / Q000473:pathology
D007166:Immunosuppressive Agents; D009824:Ointments; D016559:Tacrolimus