Fungal isobisvertinol, a new inhibitor of lipid droplet accumulation in mouse macrophages.
[structure: see text] New isobisvertinol and known bisvertinol were isolated from the culture broth of Aspergillus sp. FKI-1746. Isobisvertinol with the two alkenyl side chains extending in the same direction inhibited lipid droplet accumulation in macrophages, whereas bisvertinol with those extending in the reverse direction had almost no effect on the accumulation.
Koyama
Nobuhiro
N
School of Pharmacy, Kitasato University, Kitasato Institute for Life Sciences, Kitasato University, and the Kitasato Institute, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan.
Ohshiro
Taichi
T
Tomoda
Hiroshi
H
Omura
Satoshi
S
D000475:Alkenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D001230:Aspergillus / Q000737:chemistry*; D006575:Heterocyclic Compounds, 3-Ring / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D050356:Lipid Metabolism / Q000187:drug effects*; D008264:Macrophages / Q000187:drug effects* / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular
D000475:Alkenes; D006575:Heterocyclic Compounds, 3-Ring; D000960:Hypolipidemic Agents; C518568:bisvertinol; C518567:isobisvertinol