title: Synthesis of highly elastic biodegradable poly(urethane urea).
abstract: Linear poly(urethane urea) containing a biodegradable soft segment and a hard segment built solely from methyl-2,6-diisocyanatehexanoate (LDI) is presented, using a procedure where no chain extender is required. By having LDI in excess, together with a soft segment, and adding water in the vapor phase continuously creates amines in situ resulting in hard segments containing multiple LDI units linked via urea linkages. As soft segments, polymers of trimethylene carbonate (TMC) and copolymers of TMC, epsilon-caprolactone, and D,L-lactic acid (DLLA) were used. High inherent viscosity, 0.95-1.65 dL/g, was afforded even when DLLA-containing soft segments were used, which usually undergo aminolysis. With a hard segment content between 12% and 18%, all of the materials showed very high elongation at breakage, ranging from 1600% to 4700%, and an elastic modulus from 2.1 to 140 MPa. This one-pot synthesis is simple and has now been shown to be applicable to a large number of systems.
authors.affiliation: Department of Materials Chemistry, Uppsala University, Lägerhyddsvägen 1, 751 21 Uppsala, Sweden.
authors.forename: J O Basse
authors.initials: JO
authors.lastname: Asplund
authors.forename: Tim
authors.initials: T
authors.lastname: Bowden
authors.forename: Torbjörn
authors.initials: T
authors.lastname: Mathisen
authors.forename: Jöns
authors.initials: J
authors.lastname: Hilborn
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry*; D001673:Biodegradation, Environmental; D004146:Dioxanes / Q000737:chemistry; D004548:Elasticity; D007783:Lactones / Q000737:chemistry; D046911:Macromolecular Substances; D009682:Magnetic Resonance Spectroscopy; D008956:Models, Chemical; D008970:Molecular Weight; D011091:Polyesters; D011108:Polymers / Q000737:chemistry; D011140:Polyurethanes / Q000737:chemistry*; D011312:Pressure; D017550:Spectroscopy, Fourier Transform Infrared; D013696:Temperature; D013718:Tensile Strength; D014508:Urea / Q000737:chemistry*
chemical_list: D001672:Biocompatible Materials; D004146:Dioxanes; D007783:Lactones; D046911:Macromolecular Substances; D011091:Polyesters; D011108:Polymers; D011140:Polyurethanes; C410438:TMC-ECL copolymer; C059299:polytrimethylene carbonate; D014508:Urea