Regulation of T-cell activation by the cytoskeleton.
To become activated, T cells must efficiently recognize antigen-presenting cells or target cells through several complex cytoskeleton-dependent processes, including integrin-mediated adhesion, immunological-synapse formation, cellular polarization, receptor sequestration and signalling. The actin and microtubule systems provide the dynamic cellular framework that is required to orchestrate these processes and ultimately contol T-cell activation. Here, we discuss recent advances that have furthered our understanding of the crucial importance of the T-cell cytoskeleton in controlling these aspects of T-cell immune recognition.
Billadeau
Daniel D
DD
Department of Immunology, Mayo Clinic College of Medicine, 200 First Street South West, Rochester, Minnesota 55905, USA.
Nolz
Jeffrey C
JC
Gomez
Timothy S
TS
D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology; D003599:Cytoskeleton / Q000276:immunology*; D006801:Humans; D008213:Lymphocyte Activation / Q000276:immunology*; D051379:Mice; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology*