title: Selecting a vasopressor drug for vasoplegic shock after adult cardiac surgery: a systematic literature review.
abstract: The choice of vasopressors to treat vasodilatory shock after cardiac surgery is a matter of controversy. We have systematically reviewed the literature and found that the data are insufficient to guide choice of agent. However, we found sufficient evidence that when a target blood pressure can not be achieved with a single agent, addition of another is more likely to help achieve the blood pressure target. We also found that there is no evidence that vasopressors induce organ ischemia. Finally, the lack of high quality data indicate that large multicenter trials are needed in this field.
authors.affiliation: Department of Intensive Care and Medicine, University of Melbourne, Austin Hospital, Heidelberg Victoria, Australia.
authors.forename: Moritoki
authors.initials: M
authors.lastname: Egi
authors.forename: Rinaldo
authors.initials: R
authors.lastname: Bellomo
authors.forename: Christoph
authors.initials: C
authors.lastname: Langenberg
authors.forename: Michael
authors.initials: M
authors.lastname: Haase
authors.forename: Anja
authors.initials: A
authors.lastname: Haase
authors.forename: Laurie
authors.initials: L
authors.lastname: Doolan
authors.forename: George
authors.initials: G
authors.lastname: Matalanis
authors.forename: Siven
authors.initials: S
authors.lastname: Seevenayagam
authors.forename: Brian
authors.initials: B
authors.lastname: Buxton
mesh_terms: D002315:Cardiopulmonary Bypass / Q000009:adverse effects*; D006801:Humans; D012769:Shock / Q000188:drug therapy* / Q000209:etiology*; D014662:Vasoconstrictor Agents / Q000627:therapeutic use*; D014664:Vasodilation
chemical_list: D014662:Vasoconstrictor Agents