Effect of Sterol Inhibitors on the Incorporation of 14C-Isopentenyl Pyrophosphate into Artemisinin by a Cell-Free System from Artemisia annua Tissue Cultures and Plants.
A cell-free system from ARTEMISIA ANNUA L. shoot cultures and plants (shoots and roots) which is capable of incorporating (14)C-isopentenyl pyrophosphate ( (14)C-IPP) into artemisinin has been developed. The sterol inhibitors miconazole, AMO 1618, CCC, and MER 29 increased both the incorporation of (14)C-IPP into artemisinin by cell-free extracts and the production of artemisinin in shoot cultures of ARTEMISIA ANNUA.
Kudakasseril
G J
GJ
Department of Biology, Kenyon College, Gambier, Ohio 43022, U.S.A.
Lam
L
L
Staba
E J
EJ