title: [Study of the efficacy of combined therapy with interferon alfacon-1 and ribavirin for chronic hepatitis C].
abstract: The results of combined interferon alfacon-1 and ribavirin therapy of 94 patients with chronic hepatitis C were analyzed. Complete data, including sustained viral response (SVR), were obtained in 88 patients. 46.8% of them achieved SVR. The most important factor influencing SVR, was the presence of HCV RNA in serum at weeks 12 and 24 of therapy. SVR in these cases was achieved in 14.3% and 0%, respectively. Eight patients discontinued therapy due to adverse events. Most frequent were depressive reactions due to interferon (3 cases), and severe anemia due to ribavirin (2 cases). 37% of patients developed thyroiditis, significantly more frequent in women (27 versus 9).
authors.affiliation: Wojewódzki Szpital Zakaźny w Warszawie, Oddział Dzienny.
authors.forename: Andrzej
authors.initials: A
authors.lastname: Horban
authors.forename: Marek
authors.initials: M
authors.lastname: Wasilewski
authors.forename: Hanna
authors.initials: H
authors.lastname: Berak
authors.forename: Janusz J
authors.initials: JJ
authors.lastname: Stańczak
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Bardadin
authors.forename: Hanna
authors.initials: H
authors.lastname: Paprocka
mesh_terms: D000328:Adult; D000368:Aged; D000740:Anemia / Q000139:chemically induced; D003863:Depression / Q000139:chemically induced; D004359:Drug Therapy, Combination; D005260:Female; D019698:Hepatitis C, Chronic / Q000097:blood / Q000188:drug therapy* / Q000821:virology; D006801:Humans; D007370:Interferon Type I / Q000008:administration & dosage* / Q000009:adverse effects; D016898:Interferon-alpha; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D010976:Platelet Count; D011994:Recombinant Proteins; D012254:Ribavirin / Q000008:administration & dosage* / Q000009:adverse effects; D013966:Thyroiditis / Q000139:chemically induced; D016896:Treatment Outcome; D019562:Viral Load
chemical_list: D007370:Interferon Type I; D016898:Interferon-alpha; D011994:Recombinant Proteins; D012254:Ribavirin; C050739:interferon alfacon-1