Chronic diarrhea and malabsorption caused by Leishmania donovani.
Chronic diarrhea and malabsorption are uncommon in immunocompetent patients with visceral leishmaniasis. We report two immunocompetent patients with visceral leishmaniasis where the predominant presentation was chronic diarrhea. One of them had clinically overt malabsorption and duodenal mucosa was loaded with Leishmania donovani bodies. The other patient had diffuse colonic aphthous and discrete ulcerations and Leishmania donovani bodies were seen in the crush smears of the colonic mucosa. With amphotericin B, there was reversal of malabsorption and healing of colonic ulcers.
Baba
Chalamalasetty Sreenivasa
CS
Department of Gastroenterology and Human Nutrition, All India Institute of Medical Sciences, New Delhi 110 029, India.
Makharia
Govind K
GK
Mathur
Purva
P
Ray
Ruma
R
Gupta
Siddhartha Datta
SD
Samantaray
J C
JC
D000328:Adult; D000666:Amphotericin B / Q000627:therapeutic use; D000818:Animals; D000981:Antiprotozoal Agents / Q000627:therapeutic use; D003967:Diarrhea / Q000469:parasitology*; D005260:Female; D006801:Humans; D007413:Intestinal Mucosa / Q000469:parasitology; D007893:Leishmania donovani / Q000302:isolation & purification*; D007898:Leishmaniasis, Visceral / Q000175:diagnosis* / Q000188:drug therapy; D008286:Malabsorption Syndromes / Q000175:diagnosis / Q000469:parasitology*; D008297:Male
D000981:Antiprotozoal Agents; D000666:Amphotericin B