title: Gated SPECT findings revealing diastolic dysfunction in acute hypothyroidism.
abstract: OBJECTIVE
  The purpose of this study was to assess left ventricular (LV) function by gated SPECT in acute hypothyroidism.
  
  
  METHODS
  Thirty-eight acute hypothyroid patients without any cardiac disease and 40 healthy controls underwent gated SPECT at rest. Fourteen patients had a second examination during thyroxine replacement therapy. Gated SPECT was performed using Tc-99m sestamibi with 16 frames per cardiac cycle. The LV end-diastolic volume (EDV), end-systolic volume (ESV), ejection fraction (EF), peak ejection rate (PER), peak filling rate (PFR), and time to peak filling (TTPF) were measured by quantitative gated SPECT (QGS). Systolic wall thickening/motion was determined in 5 myocardial segments.
  
  
  RESULTS
  Hypothyroid patients exhibited a decrease in PFR (222 +/- 52 EDV/s) and prolongation of TTPF (194 +/- 32 msec) as compared with controls (247 +/- 41 EDV/s and 179 +/- 17 msec, respectively; P < 0.05). During thyroxine therapy, the mean values for EDV (74 +/- 21 mL) and PFR (265 +/- 64 EDV/s) increased significantly in 14 follow-up patients (pretreatment values 67 +/- 18 mL and 219 +/- 50 EDV/s, respectively; P < 0.05). A significant difference was detected in the mean TTPF between the thyroxine group and the controls (195 +/- 35 msec vs 179 +/- 17 msec; P < 0.05). No significant differences were found in wall thickening and motion values (P > 0.05).
  
  
  CONCLUSIONS
  Gated SPECT findings revealed diastolic dysfunction as indicated by a decrease in PFR and a prolongation in TTPF in patients with acute hypothyroidism.
authors.affiliation: Department of Nuclear Medicine, Baskent University Faculty of Medicine, Ankara, Turkey. m_aydin@yahoo.com
authors.forename: Mehmet
authors.initials: M
authors.lastname: Aydin
authors.forename: Mehmet
authors.initials: M
authors.lastname: Reyhan
authors.forename: Aysun
authors.initials: A
authors.lastname: Sukan
authors.forename: A Fuat
authors.initials: AF
authors.lastname: Yapar
authors.forename: Ayse
authors.initials: A
authors.lastname: Aktas
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D003971:Diastole / Q000502:physiology*; D005260:Female; D015637:Gated Blood-Pool Imaging; D020249:Hormone Replacement Therapy; D006801:Humans; D007037:Hypothyroidism / Q000150:complications / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000503:physiopathology*; D008297:Male; D012984:Software; D013599:Systole; D013974:Thyroxine / Q000627:therapeutic use; D015899:Tomography, Emission-Computed, Single-Photon; D018487:Ventricular Dysfunction, Left / Q000150:complications / Q000503:physiopathology*
chemical_list: D013974:Thyroxine