Retinal transplantation. A treatment strategy for retinal degenerative diseases.
Retinal transplantation is one among the various treatment strategies aimed to prevent and restore visual loss. Sheets of fetal retina with or without retinal pigment epithelium (RPE) are transplanted into the subretinal space. Retinal transplants have been shown to substantially improve visual responses in rat retinal degeneration models following retinal transplantation, based on behavior and electrophysiology. The transplantation effects may be influenced by several factors such as the age of the recipient at transplantation and the type of species used. Modified functional evaluation techniques permit better understanding of the physiological mechanisms underlying visual improvement in animal models.
Thomas
Biju B
BB
Dept. Ophthalmology, Doheny Retina Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Aramant
Robert B
RB
Sadda
SriniVas R
SR
Seiler
Magdalene J
MJ
D000818:Animals; D001519:Behavior; D001921:Brain / Q000378:metabolism; D004195:Disease Models, Animal; D004594:Electrophysiology; D004596:Electroretinography; D006801:Humans; D007700:Kinetics; D008027:Light; D020419:Photoreceptor Cells, Vertebrate / Q000378:metabolism; D010857:Pigment Epithelium of Eye / Q000378:metabolism; D051381:Rats; D012160:Retina / Q000378:metabolism / Q000637:transplantation*; D012162:Retinal Degeneration / Q000628:therapy*; D014785:Vision, Ocular