title: Malignant melanoma originating on the female nipple: a case report.
abstract: We report a very rare case of malignant melanoma arising on a female nipple. A 42-year-old housewife had suffered from a small dark brown nevus on her left nipple for about thirty years without any changes. Six months before her initial visit it had begun to enlarge and rapidly changed from dark brown to black. A small bleeding ulcer was also present in the center of the lesion. Malignant melanoma rather than mammary Paget's disease was suggested based on its clinical course. Excisional biopsy was performed to differentiate between mammary Paget's disease and malignant melanoma. The histopathological examination revealed malignant melanoma, about 4 mm in thickness. She then underwent wide excision with axillary lymph node dissection. The surgical margin was made in a 3 cm radius around the biopsy site. The excision included nipple, areola, and part of the underlying breast parenchyma, adipose tissue and corresponding superficial layer of fascia. Microscopy showed metastasis in one of 13 axillary lymph nodes. After the operation, the patient received adjuvant DAV-Ferron therapy. In such a case, conserving surgery based on correct diagnosis can achieve a good cosmetic result and optimal tumor control.
authors.affiliation: Department of Surgery, Jikei University Kashiwa Hospital, Kashiwa, Chiba, Japan. satokino@jikei.ac.jp
authors.forename: Satoki
authors.initials: S
authors.lastname: Kinoshita
authors.forename: Kazuhisa
authors.initials: K
authors.lastname: Yoshimoto
authors.forename: Shigeya
authors.initials: S
authors.lastname: Kyoda
authors.forename: Akio
authors.initials: A
authors.lastname: Hirano
authors.forename: Hisashi
authors.initials: H
authors.lastname: Shioya
authors.forename: Susumu
authors.initials: S
authors.lastname: Kobayashi
authors.forename: Takaoki
authors.initials: T
authors.lastname: Ishiji
authors.forename: Kazumasa
authors.initials: K
authors.lastname: Komine
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Takeyama
authors.forename: Ken
authors.initials: K
authors.lastname: Uchida
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Morikawa
authors.forename: Goi
authors.initials: G
authors.lastname: Sakamoto
mesh_terms: D000328:Adult; D001365:Axilla; D001943:Breast Neoplasms / Q000473:pathology* / Q000628:therapy; D017024:Chemotherapy, Adjuvant; D005260:Female; D006801:Humans; D008197:Lymph Node Excision; D008207:Lymphatic Metastasis; D008545:Melanoma / Q000473:pathology* / Q000628:therapy; D009506:Nevus / Q000473:pathology; D009558:Nipples / Q000473:pathology* / Q000601:surgery; D012878:Skin Neoplasms / Q000473:pathology* / Q000628:therapy