title: Chemo-enzymatic synthesis and biological evaluation of photolabile nicotinic acid adenine dinuclotide phosphate (NAADP+).
abstract: A chemo-enzymatic synthesis of novel caged NAADP+ without the formation of multiple cage compounds has been achieved. The biological activity of the caged NAADP+ was demonstrated by its fast uncaging in intact sea-urchin eggs.
authors.affiliation: Department of Pharmacology, University of Oxford, Mansfield Road, Oxford, OX1 3QT, UK. raman.parkesh@pharm.ox.ac.uk
authors.forename: Raman
authors.initials: R
authors.lastname: Parkesh
authors.forename: Sridhar R
authors.initials: SR
authors.lastname: Vasudevan
authors.forename: Alexandra
authors.initials: A
authors.lastname: Berry
authors.forename: Antony
authors.initials: A
authors.lastname: Galione
authors.forename: James
authors.initials: J
authors.lastname: Dowden
authors.forename: Grant C
authors.initials: GC
authors.lastname: Churchill
mesh_terms: D036541:ADP-ribosyl Cyclase / Q000378:metabolism*; D000818:Animals; D002118:Calcium / Q000378:metabolism; D002384:Catalysis; D002851:Chromatography, High Pressure Liquid; D005306:Fertilization; D013058:Mass Spectrometry; D009249:NADP / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000378:metabolism / Q000494:pharmacology; D010063:Ovum / Q000187:drug effects* / Q000378:metabolism; D010777:Photochemistry; D012617:Sea Urchins; D013329:Structure-Activity Relationship
chemical_list: D009249:NADP; C024376:NAADP; D036541:ADP-ribosyl Cyclase; D002118:Calcium