title: Acute and chronic effects of ginseng total saponin and amphetamine on fixed-interval performance of rats.
abstract: The effect of ginseng total saponin (GTS) on amphetamine (AMPH)-induced disruption of fixed-interval (Fl) responding in rats was examined. GTS (50 mg/kg) significantly improved the temporal responding impaired by 2 mg/kg of AMPH. A higher dose of 100 mg/kg GTS disrupted performance when given alone; this disruption was reversed by a low dose of AMPH (0.5 mg/kg) and tolerance developed to the effects of GTS with its repeated administration. Neurochemical analysis revealed that GTS (50 mg/kg) attenuated the increase in striatal dopamine caused by AMPH leading to the conclusion that brain dopamine may partially mediate the behavioral effects of GTS.
authors.forename: A E
authors.initials: AE
authors.lastname: Halladay
authors.forename: Y L
authors.initials: YL
authors.lastname: Lu
authors.forename: J
authors.initials: J
authors.lastname: Palmer
authors.forename: K W
authors.initials: KW
authors.lastname: Oh
authors.forename: G C
authors.initials: GC
authors.lastname: Wagner