T-cell subsets: the more the merrier.
This year, IL-17-producing T cells were recognized as a distinct lineage and soon thereafter, the cytokines responsible for their induction were delineated. Now, a transcription factor driving their development has been identified.
Weaver
Casey T
CT
Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA. cweaver@uab.edu
Murphy
Kenneth M
KM
D000818:Animals; D015704:CD4 Antigens / Q000378:metabolism; D019070:Cell Lineage / Q000276:immunology; D020381:Interleukin-17 / Q000378:metabolism*; D051379:Mice; D057132:Nuclear Receptor Subfamily 1, Group F, Member 3; D018168:Receptors, Retinoic Acid / Q000378:metabolism*; D011988:Receptors, Thyroid Hormone / Q000378:metabolism*; D016176:T-Lymphocyte Subsets / Q000378:metabolism*
D015704:CD4 Antigens; D020381:Interleukin-17; D057132:Nuclear Receptor Subfamily 1, Group F, Member 3; D018168:Receptors, Retinoic Acid; D011988:Receptors, Thyroid Hormone; C539901:Rorc protein, mouse