title: Synthesis and evaluation of urea and thiourea derivatives of oxazolidinones as antibacterial agents.
abstract: Urea and thiourea derivatives of oxazolidinones were synthesized and their inhibitory activity (MIC) was determined on the bacterial strains which includes clinical isolates and quality control organisms. The structure activity relationships were studied and a 3D-QSAR model was built using Genetic Function Approximation. Interestingly found that electron withdrawing groups at the ortho position of the phenyl ring enhances the activity.
authors.affiliation: New Drug Discovery, Orchid Chemicals & Pharmaceuticals Ltd., Chennai, Tamilnadu, India. sunil@scientist.com
authors.forename: Sunil Kumar Reddy
authors.initials: SK
authors.lastname: Aaramadaka
authors.forename: Mrinal Kanthi
authors.initials: MK
authors.lastname: Guha
authors.forename: Ganesh
authors.initials: G
authors.lastname: Prabhu
authors.forename: Suvarna Ganesh
authors.initials: SG
authors.lastname: Kini
authors.forename: Magesh
authors.initials: M
authors.lastname: Vijayan
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D013293:Enterococcus faecalis / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D023303:Oxazolidinones / Q000138:chemical synthesis / Q000494:pharmacology*; D021281:Quantitative Structure-Activity Relationship; D013210:Staphylococcus / Q000187:drug effects*; D013890:Thiourea / Q000737:chemistry*; D014508:Urea / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D023303:Oxazolidinones; D014508:Urea; D013890:Thiourea