title: Serological and clinical comparison of children and adults with anti-endomysial antibodies.
abstract: We compared serological and clinical presentation of 38 adults (5 males, 33 females) and 37 children (15 boys, 22 girls) with anti-endomysial antibodies (AEA).AEA, antinuclear (ANA), anti-parietal (APA), anti-thyroid microsomal (ATMA), anti-thyreoglobulin (ATGA), anti-smooth muscle (SMA) and anti-mitochondrial (AMA) antibodies were detected by IIF. Anti-tissue transglutaminase (tTG), anti-extractable nuclear antigens (ENA) and anti-actin (AAA) antibodies were studied by ELISA. There were no differences in frequency of ANA, APA, ATGA, SMA, AMA and AAA in children and adults. ATMA (p < 0.001) and anti-ENA (p < 0.05) positivity were more frequently found in adults. Anti-Ro/SSA had 7/38 adults and 1/37 children (p < 0.05). Adults had more frequently silent form of celiac disease associated with autoimmune diseases (p < 0.001). We are the first to demonstrate that in spite of no difference in ANA positivity in adults and children, ANA in adults more frequently target ENA, especially Ro/SSA antigen. The reason for this ANA specificity could be the longer gluten exposure in adults.
authors.affiliation: Institute of Allergy and Clinical Immunology, Clinical Center of Serbia, Koste Todorovica 2, 11000 Belgrade, Serbia. branka_bonaci@yahoo.com
authors.forename: Branka
authors.initials: B
authors.lastname: Bonaci-Nikolic
authors.forename: Sladjana
authors.initials: S
authors.lastname: Andrejevic
authors.forename: Nedeljko
authors.initials: N
authors.lastname: Radlovic
authors.forename: Ivana
authors.initials: I
authors.lastname: Davidovic
authors.forename: Ljiljana
authors.initials: L
authors.lastname: Sofronic
authors.forename: Milan
authors.initials: M
authors.lastname: Spuran
authors.forename: Marjan
authors.initials: M
authors.lastname: Micev
authors.forename: Milos M
authors.initials: MM
authors.lastname: Nikolic
mesh_terms: D000328:Adult; D000367:Age Factors; D001323:Autoantibodies / Q000097:blood*; D001327:Autoimmune Diseases / Q000097:blood / Q000150:complications / Q000276:immunology; D002446:Celiac Disease / Q000097:blood* / Q000150:complications / Q000276:immunology*; D002648:Child; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D008297:Male; D012737:Sex Factors
chemical_list: D001323:Autoantibodies; D007070:Immunoglobulin A