Neurogenesis after traumatic brain injury.
With the hope of replacing neurons lost in traumatic brain injury (TBI), experimental models are being used to investigate TBI-induced neurogenesis. Although selectively vulnerable to TBI, the neurogenic hippocampus may have the unique ability to replace damaged neurons locally. Injury may also activate signaling pathways that induce neuroblasts from the subventricular zone to migrate to areas of focal cortical damage. Additionally, there is some evidence for local activation of latent neural progenitor cells in the injured neocortex itself. Each of these themes is discussed, with emphasis on the possibility of future therapeutic intervention.
Richardson
R Mark
RM
Department of Neurological Surgery, University of California San Francisco, 505 Parnassus Avenue, Room M779, San Francisco, CA 94143-0112, USA. richardsonma@neurosurg.ucsf.edu
Sun
Dong
D
Bullock
M Ross
MR
D053687:Adult Stem Cells / Q000166:cytology / Q000502:physiology*; D000818:Animals; D001930:Brain Injuries / Q000473:pathology* / Q000503:physiopathology*; D002552:Cerebral Ventricles / Q000166:cytology / Q000502:physiology; D006801:Humans; D009416:Nerve Regeneration / Q000502:physiology*; D009474:Neurons / Q000166:cytology / Q000502:physiology*