title: Serum chemical elements and oxidative status in Alzheimer's disease, Parkinson disease and multiple sclerosis.
abstract: The role of some chemical elements in neurodegeneration was suggested by various authors. To obtain a profile of chemical elements and oxidative status in complex neurological diseases, an unbiased "omics" approach, i.e., quantification of 26 elements and oxidative stress parameters (serum oxidative status (SOS) and serum anti-oxidant capacity (SAC)), combined with multivariate statistical procedures (forward discriminant analysis, FDA) to analyse the vast amount of data, was applied to four groups of subjects (53 patients with Alzheimer's disease (AD), 71 with Parkinson disease (PD), 60 with multiple sclerosis (MS) and 124 healthy individuals). Descriptive statistics revealed numerous differences between each disease and healthy status. A concordant imbalance (reduction in Fe, Zn and SAC, and increase in SOS) was shared by AD, PD and MS. The FDA yielded three significant discriminant functions based on age, SOS, Ca, Fe, Si, Sn, V, Zn and Zr, and identified disease-specific profiles of element imbalances, thus showing the appropriateness of the "omics" approach. It may help assess the contribution of chemical elements and oxidative stress to disease causation and may provide complex predictors of disease evolution or treatment response.
authors.affiliation: Department of the Environment and Primary Prevention, Istituto Superiore di Sanità, Viale Regine Elena 299, 00161 Rome, Italy. alessandro.alimonti@iss.it
authors.forename: Alessandro
authors.initials: A
authors.lastname: Alimonti
authors.forename: Giovanni
authors.initials: G
authors.lastname: Ristori
authors.forename: Franco
authors.initials: F
authors.lastname: Giubilei
authors.forename: Maria Antonia
authors.initials: MA
authors.lastname: Stazi
authors.forename: Anna
authors.initials: A
authors.lastname: Pino
authors.forename: Andrea
authors.initials: A
authors.lastname: Visconti
authors.forename: Sonia
authors.initials: S
authors.lastname: Brescianini
authors.forename: Micaela
authors.initials: M
authors.lastname: Sepe Monti
authors.forename: Giovanni
authors.initials: G
authors.lastname: Forte
authors.forename: Paolo
authors.initials: P
authors.lastname: Stanzione
authors.forename: Beatrice
authors.initials: B
authors.lastname: Bocca
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Bomboi
authors.forename: Cristina
authors.initials: C
authors.lastname: D'Ippolito
authors.forename: Viviana
authors.initials: V
authors.lastname: Annibali
authors.forename: Marco
authors.initials: M
authors.lastname: Salvetti
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Sancesario
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000097:blood*; D000704:Analysis of Variance; D015415:Biomarkers; D004602:Elements; D005260:Female; D005609:Free Radicals / Q000378:metabolism; D006801:Humans; D006861:Hydrogen Peroxide / Q000378:metabolism; D008297:Male; D008670:Metals / Q000097:blood; D008875:Middle Aged; D016877:Oxidants / Q000097:blood*; D010084:Oxidation-Reduction; D010300:Parkinson Disease / Q000097:blood*
chemical_list: D015415:Biomarkers; D004602:Elements; D005609:Free Radicals; D008670:Metals; D016877:Oxidants; D006861:Hydrogen Peroxide