title: [Intravesical instillation of resiniferatoxin for the patients with interstitial cystitis].
abstract: Although hydrodistention of the bladder is accepted as the initial treatment for patients with interstitial cystitis (IC), second-line treatment for worsening symptoms is not concretely established. Resiniferatoxin (RTX) desensitizes bladder afferent c-fibers and its intravesical instillation is effective for patients with detrusor overactivity. We studied the clinical relevance of intravesical treatment with RTX for patients with IC. The treatment was performed for 3 patients with incomplete improvement after hydrodistention. All 3 patients were free of bladder pain posttreatment and had slight improvement of the maximum voided volume. Though RTX treatment requires general anesthesia against severe bladder pain it is effective for selected patients with interstitial cystitis and can be potentially used as one of the treatment options.
authors.affiliation: Department of Urology, Sapporo Medical University School of Medicine.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Takahashi
authors.forename: Masahiro
authors.initials: M
authors.lastname: Yanase
authors.forename: Ryuta
authors.initials: R
authors.lastname: Inoue
authors.forename: Kohji
authors.initials: K
authors.lastname: Ichihara
authors.forename: Naoya
authors.initials: N
authors.lastname: Masumori
authors.forename: Taiji
authors.initials: T
authors.lastname: Tsukamoto
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Igawa
authors.forename: Osamu
authors.initials: O
authors.lastname: Nishizawa
mesh_terms: D000283:Administration, Intravesical; D000368:Aged; D018856:Cystitis, Interstitial / Q000188:drug therapy*; D004224:Diterpenes / Q000008:administration & dosage*; D005260:Female; D006801:Humans
chemical_list: D004224:Diterpenes; C024353:resiniferatoxin