Catalytic asymmetric synthesis of mycocerosic acid.
The first catalytic asymmetric total synthesis of mycocerosic acid was achieved via the application of iterative enantioselective 1,4-addition reactions and allows for the efficient construction of 1,3-polymethyl arrays with full stereocontrol; further exemplified by the synthesis of tetramethyl-decanoic acid, a component of the preen-gland wax of the graylag goose, Anser anser.
ter Horst
Bjorn
B
Department of Organic and Molecular Inorganic Chemistry, Stratingh Institute, University of Groningen, Nijenborgh 4, 9747 AG, Groningen, The Netherlands.
Feringa
Ben L
BL
Minnaard
Adriaan J
AJ
D002384:Catalysis; D002625:Chemistry, Organic / Q000379:methods*; D005227:Fatty Acids / Q000138:chemical synthesis*
D005227:Fatty Acids; C032992:mycocerosic acid