title: Refinement of two female fertility QTL using alternative phenotypes in French Holstein dairy cattle.
abstract: Two quantitative trait loci (QTL) affecting female fertility were mapped in French dairy cattle. Phenotypes were non-return rates at 28, 56, 90 and 282 days after insemination. On chromosome 3, a QTL was significant at 1% for non-return rate at 90 days, suggesting that it affects early fertility events. An analysis of SLC35A3, which causes complex vertebral malformation, excluded this gene from the QTL interval. On chromosome 7, a QTL was almost significant (P = 0.05) for non-return rate at 282 days. This QTL was associated with abortion and stillbirth problems. Use of appropriate phenotypes appeared important for fine-mapping QTL associated with fertility.
authors.affiliation: INRA, UR337, Station de Génétique Quantitative et Appliquée, Jouy-en-Josas F-78350, France. francois.guillaume@jouy.inra.fr
authors.forename: F
authors.initials: F
authors.lastname: Guillaume
authors.forename: M
authors.initials: M
authors.lastname: Gautier
authors.forename: S
authors.initials: S
authors.lastname: Ben Jemaa
authors.forename: S
authors.initials: S
authors.lastname: Fritz
authors.forename: A
authors.initials: A
authors.lastname: Eggen
authors.forename: D
authors.initials: D
authors.lastname: Boichard
authors.forename: T
authors.initials: T
authors.lastname: Druet
mesh_terms: D000818:Animals; D002417:Cattle / Q000235:genetics* / Q000502:physiology; D002874:Chromosome Mapping; D033481:Chromosomes, Mammalian; D005260:Female; D005298:Fertility / Q000235:genetics*; D008040:Genetic Linkage; D005838:Genotype; D016013:Likelihood Functions; D008297:Male; D018895:Microsatellite Repeats; D010641:Phenotype; D040641:Quantitative Trait Loci