title: Chronic diarrhea and malabsorption caused by Leishmania donovani.
abstract: Chronic diarrhea and malabsorption are uncommon in immunocompetent patients with visceral leishmaniasis. We report two immunocompetent patients with visceral leishmaniasis where the predominant presentation was chronic diarrhea. One of them had clinically overt malabsorption and duodenal mucosa was loaded with Leishmania donovani bodies. The other patient had diffuse colonic aphthous and discrete ulcerations and Leishmania donovani bodies were seen in the crush smears of the colonic mucosa. With amphotericin B, there was reversal of malabsorption and healing of colonic ulcers.
authors.affiliation: Department of Gastroenterology and Human Nutrition, All India Institute of Medical Sciences, New Delhi 110 029, India.
authors.forename: Chalamalasetty Sreenivasa
authors.initials: CS
authors.lastname: Baba
authors.forename: Govind K
authors.initials: GK
authors.lastname: Makharia
authors.forename: Purva
authors.initials: P
authors.lastname: Mathur
authors.forename: Ruma
authors.initials: R
authors.lastname: Ray
authors.forename: Siddhartha Datta
authors.initials: SD
authors.lastname: Gupta
authors.forename: J C
authors.initials: JC
authors.lastname: Samantaray
mesh_terms: D000328:Adult; D000666:Amphotericin B / Q000627:therapeutic use; D000818:Animals; D000981:Antiprotozoal Agents / Q000627:therapeutic use; D003967:Diarrhea / Q000469:parasitology*; D005260:Female; D006801:Humans; D007413:Intestinal Mucosa / Q000469:parasitology; D007893:Leishmania donovani / Q000302:isolation & purification*; D007898:Leishmaniasis, Visceral / Q000175:diagnosis* / Q000188:drug therapy; D008286:Malabsorption Syndromes / Q000175:diagnosis / Q000469:parasitology*; D008297:Male
chemical_list: D000981:Antiprotozoal Agents; D000666:Amphotericin B