title: [Perceptions of patients and physicians involved in clinical trials: an overview of the literature].
abstract: OBJECTIVE - METHOD: The purpose of this review is to explore the expectations of patients and physicians prior to participate to a clinical trial and their positive or negative experiences after participating. A systematic review of Medline database from 1966 to 2005 identified 79 papers reported patients and physicians perceptions of clinical trials (only 3 in French), whom 27 English surveys conducted on patients and physicians.
  
  
  RESULTS
  If primary patients' motivation for enrolment was altruistic, physicians wish to help their patient. After enrolment, the most perceived positive benefit for patients and physicians are, respectively, the emotional improvement and the greater opportunity for personal benefit offered to enrolled patients. Most physicians' negative experience included logistical difficulties while patients are unease with randomisation and often uncomfortable with medical procedures. Unlike patients, all physicians' expectations seem to be fulfilled.
  
  
  CONCLUSIONS
  The knowledge of patients' and physicians' perception of participation may improve recruitment in clinical trials.
authors.affiliation: Service Pharmaceutique, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, France. agnes.henry@chu-lyon.fr
authors.forename: Agnès
authors.initials: A
authors.lastname: Henry
authors.forename: Stéphane
authors.initials: S
authors.lastname: Corvaisier
authors.forename: Sandrine
authors.initials: S
authors.lastname: Blanc
authors.forename: François
authors.initials: F
authors.lastname: Berthezene
authors.forename: Françoise
authors.initials: F
authors.lastname: Borson-Chazot
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Broussolle
authors.forename: Philippe
authors.initials: P
authors.lastname: Ryvlin
authors.forename: Paul
authors.initials: P
authors.lastname: Touboul
mesh_terms: D001291:Attitude of Health Personnel; D002986:Clinical Trials as Topic / Q000523:psychology*; D005602:France; D006801:Humans; D009042:Motivation; D010361:Patients / Q000523:psychology*; D010820:Physicians / Q000523:psychology*