Tuberculous meningitis in HIV-infected patients: drug susceptibility and clinical outcome.
The objective of this study was to identify prognostic factors of death in patients with tuberculous meningitis (TM) and show the impact of infection by multidrug-resistant strains on the outcome of this disease. We retrospectively analysed clinical charts of HIV-infected patients with culture-confirmed TM attending our institution during 1996-2004. The following variables were associated with death during hospitalization: neurological signs at admission, a CD4 T-cell count less than 50 cells/microl and infection by multidrug-resistant strains.
Cecchini
Diego
D
Infectious Diseases Division, Infectious Diseases Francisco Javier Muñiz Hospital, Buenos Aires, Argentina.
Ambrosioni
Juan
J
Brezzo
Clarisa
C
Corti
Marcelo
M
Rybko
Ana
A
Perez
Marcela
M
Poggi
Susana
S
Ambroggi
Marta
M
D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy* / Q000276:immunology / Q000382:microbiology; D000328:Adult; D000995:Antitubercular Agents / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D011379:Prognosis; D012189:Retrospective Studies; D016896:Treatment Outcome; D014390:Tuberculosis, Meningeal / Q000188:drug therapy* / Q000276:immunology / Q000382:microbiology; D018088:Tuberculosis, Multidrug-Resistant / Q000188:drug therapy* / Q000276:immunology / Q000382:microbiology
D000995:Antitubercular Agents