title: Hepatitis C virus infection in hemodialysis patients in Sudan: two centers' report.
abstract: Prevalence of HCV seropositivity among the hemodialysis population in Sudan is estimated to be around 34%. We undertook a cross sectional study in two major HD centers in Khartoum, Sudan for the prevalence of HCV seropositivity among the hemodialysis patients, during January to March 2005. Testing for HCV antibodies was performed using 3rd generation enzyme linked immunoadsorption assay (ELISA). A total of 236 patients were included in the study: 218 adults and 18 children. The mean age was 43.6 +/- 15.6 years, and the majority was males: 71.6%. The cause of renal failure was unknown in 168 patients (71.2%). The mean HD duration was 36.6 +/- 35.1 months. Prevalence of HCV seropositivity was 23.7%. Among 170 patients who were previously HCV seronegative, 30 (17.1%) seroconverted to positive in one year (estimated incidence: 63 new cases per year). HCV seropositivity was associated with longer duration of dialysis (p < 0.00001), previous surgery (p= 0.026), age of over 30 and years (p = 0.008), and dialysis in multiple centers (p= 0.005). We conclude that although HCV seropositivity in our study was lower than previously reported, it was still high among HD patients in Sudan. Nosocomial transmission of HCV among hemodialysis patients is a contributing factor.
authors.affiliation: Dr. Salma Center for Dialysis and Kidney Transplantation, University of Khartoum, Sudan.
authors.forename: H H
authors.initials: HH
authors.lastname: El-Amin
authors.forename: E M
authors.initials: EM
authors.lastname: Osman
authors.forename: M O
authors.initials: MO
authors.lastname: Mekki
authors.forename: M B
authors.initials: MB
authors.lastname: Abdelraheem
authors.forename: M O
authors.initials: MO
authors.lastname: Ismail
authors.forename: M E A
authors.initials: ME
authors.lastname: Yousif
authors.forename: A M
authors.initials: AM
authors.lastname: Abass
authors.forename: H S
authors.initials: HS
authors.lastname: El-haj
authors.forename: H K
authors.initials: HK
authors.lastname: Ammar
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D002648:Child; D003428:Cross Infection / Q000453:epidemiology* / Q000209:etiology / Q000635:transmission / Q000821:virology; D003430:Cross-Sectional Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006526:Hepatitis C / Q000453:epidemiology* / Q000209:etiology / Q000635:transmission / Q000821:virology; D018937:Hepatitis C Antibodies / Q000097:blood; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D006435:Renal Dialysis; D012307:Risk Factors; D016036:Seroepidemiologic Studies; D013397:Sudan / Q000453:epidemiology; D011795:Surveys and Questionnaires; D013997:Time Factors
chemical_list: D018937:Hepatitis C Antibodies