title: Antinociceptive and anti-inflammatory properties of Corchorus capsularis leaves chloroform extract in experimental animal models.
abstract: The antinociceptive and anti-inflammatory properties of Corchorus capsularis leaves chloroform extract were investigated in experimental animal models. The antinociceptive activity was measured using the writhing, hot plate and formalin tests, while the anti-inflammatory activity was measured using the carrageenan-induced paw edema test. The extract, obtained after 72 h soaking of the air-dried leaves in chloroform followed by in vacuo evaporation to dryness, was weighed and prepared by serial dilution in DMSO in the doses of 20, 100 and 200 mg/kg. The extract was administered (s.c.) 30 min prior to subjection to the respective assays. The extract was found to exhibit significant (p < 0.05) antinociceptive and anti-inflammatory activities. As a conclusion, the present study confirmed the traditional claims of using C. capsularis to treat various ailments related to inflammation and pain.
authors.affiliation: Faculty of Biotechnology and Life Sciences, Universiti Industri Selangor, Selangor, Malaysia. shaza8174@yahoo.com
authors.forename: Zainul Amiruddin
authors.initials: ZA
authors.lastname: Zakaria
authors.forename: Mohd Roslan
authors.initials: MR
authors.lastname: Sulaiman
authors.forename: Hanan Kumar
authors.initials: HK
authors.lastname: Gopalan
authors.forename: Zuleen Delina Fasya
authors.initials: ZD
authors.lastname: Abdul Ghani
authors.forename: Raden Nur Suraya
authors.initials: RN
authors.lastname: Raden Mohd Nor
authors.forename: Abdul Manan
authors.initials: AM
authors.lastname: Mat Jais
authors.forename: Fatimah Corazon
authors.initials: FC
authors.lastname: Abdullah
mesh_terms: D000700:Analgesics / Q000302:isolation & purification* / Q000627:therapeutic use*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000302:isolation & purification* / Q000627:therapeutic use*; D002725:Chloroform; D032381:Corchorus / Q000737:chemistry*; D004487:Edema / Q000517:prevention & control*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D023421:Models, Animal; D010146:Pain / Q000517:prevention & control*; D008517:Phytotherapy; D010936:Plant Extracts / Q000302:isolation & purification* / Q000627:therapeutic use*; D018515:Plant Leaves / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000700:Analgesics; D000893:Anti-Inflammatory Agents; D010936:Plant Extracts; D002725:Chloroform