title: Colchicine use in children and adolescents with familial Mediterranean fever: literature review and consensus statement.
abstract: The daily application of colchicine is the standard therapy for prophylaxis of attacks and amyloid deposition in familial Mediterranean fever. However, because of many issues (eg, dosage, time of introduction, etc), no standardized treatment recommendations have been established. In this work we review the available literature on colchicine use with respect to its indication, efficacy, mode of application, and safety in children and adolescents with familial Mediterranean fever. On the basis of this analysis, a consensus statement on the application of colchicine in children and adolescents with familial Mediterranean fever was developed by caregivers from Germany, Austria, and Turkey.
authors.affiliation: Department of Pediatric Pneumology and Immunology, Charite-Universitätsmedizin Berlin, Campus Virchow-Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany. tilmann.kallinich@charite.de
authors.forename: Tilmann
authors.initials: T
authors.lastname: Kallinich
authors.forename: Dieter
authors.initials: D
authors.lastname: Haffner
authors.forename: Tim
authors.initials: T
authors.lastname: Niehues
authors.forename: Kristina
authors.initials: K
authors.lastname: Huss
authors.forename: Elke
authors.initials: E
authors.lastname: Lainka
authors.forename: Ulrich
authors.initials: U
authors.lastname: Neudorf
authors.forename: Christof
authors.initials: C
authors.lastname: Schaefer
authors.forename: Silvia
authors.initials: S
authors.lastname: Stojanov
authors.forename: Christian
authors.initials: C
authors.lastname: Timmann
authors.forename: Rolf
authors.initials: R
authors.lastname: Keitzer
authors.forename: Huri
authors.initials: H
authors.lastname: Ozdogan
authors.forename: Seza
authors.initials: S
authors.lastname: Ozen
mesh_terms: D000293:Adolescent; D002648:Child; D003078:Colchicine / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D010505:Familial Mediterranean Fever / Q000188:drug therapy*; D006801:Humans
chemical_list: D003078:Colchicine