title: Antifungal acylcyclopentenediones from fruiting bodies of Hygrophorus chrysodon.
abstract: Chrysotriones A (1) and B (2), two new 2-acylcyclopentene-1,3-dione derivatives, were isolated from the fruiting bodies of the Basidiomycete Hygrophorus chrysodon, and their structures were established by spectroscopic data and synthesis of compound 2. They represent the first examples of 2-acylcyclopentene-1,3-diones found in mushrooms and suggest an unprecedented biosynthetic pathway, starting from fatty acid derivatives. Initial tests indicated interesting antifungal activity of chrysotriones against Fusarium verticillioides, one of the common worldwide pathogens of cultivated plants.
authors.affiliation: Dipartimento di Chimica Organica, Università di Pavia, Via Taramelli 10, 27100 Pavia, Italy.
authors.forename: Gianluca
authors.initials: G
authors.lastname: Gilardoni
authors.forename: Marco
authors.initials: M
authors.lastname: Clericuzio
authors.forename: Solveig
authors.initials: S
authors.lastname: Tosi
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Zanoni
authors.forename: Giovanni
authors.initials: G
authors.lastname: Vidari
mesh_terms: D000363:Agaricales / Q000737:chemistry*; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D003517:Cyclopentanes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D048690:Fruiting Bodies, Fungal / Q000737:chemistry; D005670:Fusarium / Q000187:drug effects*; D007558:Italy; D015394:Molecular Structure
chemical_list: D000935:Antifungal Agents; D003517:Cyclopentanes