Strong association between HLA-A*0206 and Stevens-Johnson syndrome in the Japanese.
OBJECTIVE
To investigate the association between HLA class I antigens and Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) with ocular complications in Japanese.


METHODS
Case-control study.


METHODS
We examined the histocompatibility antigen genes HLA-A, -B, and -C of 40 Japanese SJS/TEN patients with ocular complications and 113 healthy Japanese volunteers by polymerase chain reaction amplification and subsequent hybridization with sequence-specific oligonucleotide probes (PCR-SSO).


RESULTS
We clarified that HLA-A*0206 is strongly associated with SJS/TEN with ocular complications in the Japanese.


CONCLUSIONS
Because this finding is completely different from data reported elsewhere on Taiwanese Han Chinese patients and Caucasian patients, it suggests strong ethnic differences in the HLA-SJS association and points to the need for studies in other ethnic populations in order to obtain a global picture.
Ueta
Mayumi
M
Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kawaramachi, Kyoto, Japan. mueta@ophth.kpu-m.ac.jp
Sotozono
Chie
C
Tokunaga
Katsushi
K
Yabe
Toshio
T
Kinoshita
Shigeru
S
D044466:Asian People / Q000208:ethnology; D016022:Case-Control Studies; D003231:Conjunctivitis / Q000208:ethnology / Q000235:genetics*; D005784:Gene Amplification; D005787:Gene Frequency; D005838:Genotype; D015234:HLA-A Antigens / Q000235:genetics*; D015789:HLA-A2 Antigen; D006801:Humans; D017403:In Situ Hybridization; D007564:Japan / Q000453:epidemiology; D015345:Oligonucleotide Probes; D016133:Polymerase Chain Reaction; D013262:Stevens-Johnson Syndrome / Q000208:ethnology / Q000235:genetics*
D015234:HLA-A Antigens; C503735:HLA-A*02:61 antigen; D015789:HLA-A2 Antigen; D015345:Oligonucleotide Probes