title: Cardiometabolic risk in impaired fasting glucose and impaired glucose tolerance: the Atherosclerosis Risk in Communities Study.
abstract: OBJECTIVE
  We compared and contrasted cardiovascular disease (CVD) risk factors, subclinical manifestations of CVD, incident coronary heart disease (CHD), and all-cause mortality by categories of impaired glucose regulation in nondiabetic individuals.
  
  
  METHODS
  The study included 6,888 participants aged 52-75 years who had no history of diabetes or CVD. All-cause mortality and incident CHD were ascertained over a median of 6.3 years of follow-up.
  
  
  RESULTS
  Agreement between fasting and postchallenge glucose impairment was poor: 3,048 subjects (44%) had neither impaired fasting glucose (IFG) nor impaired glucose tolerance (IGT), 1,690 (25%) had isolated IFG, 1,000 (14%) had isolated IGT, and 1,149 (17%) had both IFG and IGT. After adjustment for age, sex, race, and center, subjects with isolated IFG were more likely to smoke, consume alcohol, and had higher mean BMI, waist circumference, LDL cholesterol, and fasting insulin and lower HDL cholesterol than those with isolated IGT, while subjects with isolated IGT had higher mean triglycerides, systolic blood pressure, and white cell counts. Measures of subclinical CVD and rates of all-cause mortality and incident CHD were similar in isolated IFG and isolated IGT.
  
  
  CONCLUSIONS
  Neither isolated IFG nor isolated IGT was associated with a more adverse CVD risk profile.
authors.affiliation: Division of EpidemiologyCommunity Health, University of Minnesota, 1300 South Second Street, Suite 300, Minneapolis, MN 55454, USA. pankow@epi.umn.edu
authors.forename: James S
authors.initials: JS
authors.lastname: Pankow
authors.forename: David K
authors.initials: DK
authors.lastname: Kwan
authors.forename: Bruce B
authors.initials: BB
authors.lastname: Duncan
authors.forename: Maria I
authors.initials: MI
authors.lastname: Schmidt
authors.forename: David J
authors.initials: DJ
authors.lastname: Couper
authors.forename: Sherita
authors.initials: S
authors.lastname: Golden
authors.forename: Christie M
authors.initials: CM
authors.lastname: Ballantyne
mesh_terms: D000368:Aged; D050197:Atherosclerosis / Q000453:epidemiology* / Q000401:mortality; D044383:Black People / Q000706:statistics & numerical data; D001786:Blood Glucose / Q000032:analysis*; D015992:Body Mass Index; D003327:Coronary Disease / Q000453:epidemiology / Q000401:mortality; D005215:Fasting; D005260:Female; D018149:Glucose Intolerance / Q000453:epidemiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D044469:Racial Groups; D012307:Risk Factors; D016019:Survival Analysis; D017539:Tunica Intima / Q000033:anatomy & histology / Q000473:pathology; D017540:Tunica Media / Q000033:anatomy & histology / Q000473:pathology; D014481:United States / Q000453:epidemiology; D044465:White People / Q000706:statistics & numerical data; D001741:Black or African American
chemical_list: D001786:Blood Glucose