title: Synthesis and evaluation as MRI probe of the trifluoromethylated p-boronophenylalanine and its alcohol derivative.
abstract: Boron-neutron capture therapy (BNCT) and magnetic resonance imaging (MRI) are quite attractive techniques for treatment and diagnosis of cancer, respectively. In order to develop practical tools for BNCT and MRI, novel compounds containing both the trifluoromethyl group and 10B atom in a single molecule were designed. In the present study, p-boronophenylalanine and p-boronophenylalaninol with the trifluoromethyl group were synthesized, and 19F NMR measurements of these compounds were carried out.
authors.affiliation: Faculty of Science and Technology, Kinki University, Higashi-osaka, Osaka 577-8502, Japan.
authors.forename: Yoshihide
authors.initials: Y
authors.lastname: Hattori
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Yamamoto
authors.forename: Hideya
authors.initials: H
authors.lastname: Ando
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Kondoh
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Asano
authors.forename: Mitsunori
authors.initials: M
authors.lastname: Kirihata
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Yamaguchi
authors.forename: Tateaki
authors.initials: T
authors.lastname: Wakamiya
mesh_terms: D000438:Alcohols / Q000737:chemistry*; D001896:Boron Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D015335:Molecular Probes; D010649:Phenylalanine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
chemical_list: D000438:Alcohols; D001896:Boron Compounds; D015335:Molecular Probes; D010649:Phenylalanine; C033685:4-boronophenylalanine