title: Towards organo-click reactions: development of pharmaceutical ingredients by using direct organocatalytic bio-mimetic reductions.
abstract: Economic and environmentally friendly bio-mimetic one-pot three and four-component Knoevenagel-hydrogenation (K-H), five-component Knoevenagel-hydrogenation-alkylation (K-H-A) and six-component Knoevenagel-hydrogenation-alkylation-Huisgen cycloaddition (K-H-A-HC) reactions of aldehydes, CH-acids, o-phenylenediamine, alkyl halides and azides using proline, proline-metal carbonate and proline-metal carbonate-Cu(I)-catalysis, respectively have been developed. Many of K-H and K-H-A compounds have direct application in pharmaceutical chemistry.
authors.affiliation: School of Chemistry, University of Hyderabad, Hyderabad, 500 046, India. ramsc@uohyd.ernet.in
authors.forename: Dhevalapally B
authors.initials: DB
authors.lastname: Ramachary
authors.forename: G Babul
authors.initials: GB
authors.lastname: Reddy
mesh_terms: D032701:Biomimetics; D002384:Catalysis; D006540:Herbicides / Q000737:chemistry*; D015394:Molecular Structure; D010084:Oxidation-Reduction; D004364:Pharmaceutical Preparations / Q000737:chemistry*
chemical_list: D006540:Herbicides; D004364:Pharmaceutical Preparations