Electrically evoked auditory steady-state responses in Guinea pigs.
Most cochlear implant systems available today provide the user with information about the envelope of the speech signal. The goal of this study was to explore the feasibility of recording electrically evoked auditory steady-state response (ESSR) and in particular to evaluate the degree to which the response recorded using electrical stimulation could be separated from stimulus artifact. Sinusoidally amplitude-modulated electrical stimuli with alternating polarities were used to elicit the response in adult guinea pigs. Separation of the stimulus artifact from evoked neural responses was achieved by summing alternating polarity responses or by using spectral analysis techniques. The recorded response exhibited physiological response properties including a pattern of nonlinear growth and their abolishment following euthanasia or administration of tetrodotoxin. These findings demonstrate that the ESSR is a response generated by the auditory system and can be separated from electrical stimulus artifact. As it is evoked by a stimulus that shares important features of cochlear implant stimulation, this evoked potential may be useful in either clinical or basic research efforts.
Jeng
Fuh-Cherng
FC
Department of Speech Pathology and Audiology, Department of Otolaryngology--HNS, University of Iowa, Iowa City, Iowa, USA. jeng@ohio.edu
Abbas
Paul J
PJ
Brown
Carolyn J
CJ
Miller
Charles A
CA
Nourski
Kirill V
KV
Robinson
Barbara K
BK
D000161:Acoustic Stimulation / Q000379:methods; D000779:Anesthetics, Local / Q000494:pharmacology; D000818:Animals; D016477:Artifacts; D001307:Auditory Perception / Q000502:physiology*; D003054:Cochlear Implants; D004195:Disease Models, Animal; D004558:Electric Stimulation / Q000379:methods*; D005072:Evoked Potentials, Auditory / Q000187:drug effects / Q000502:physiology*; D006168:Guinea Pigs; D006319:Hearing Loss, Sensorineural / Q000139:chemically induced / Q000503:physiopathology* / Q000628:therapy; D013779:Tetrodotoxin / Q000494:pharmacology
D000779:Anesthetics, Local; D013779:Tetrodotoxin