title: [Wilms' tumors in adults].
abstract: Wilms' tumors develop from persistent, primitive metanephrogenic stem cells. Their biology and etiology in adults is still unknown even though remnants of primitive metanephrogenic tissue, which tends to malignancy, is suspected, and there are very few scientific studies on the biology of Wilms' tumors in adults. Such a tumor occurs at a rate of 0.2/million adults in Europe and the USA. In this article, we describe the course of the disease in two adults with histologically confirmed Wilms' tumors. Both patients underwent a radical nephrectomy followed by chemotherapy as indicated by the SIOP nephroblastoma study.
authors.affiliation: Urologische Klinik mit Poliklinik, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054, Erlangen. vahudin.zugor@uro.imed.uni-erlangen.de
authors.forename: V
authors.initials: V
authors.lastname: Zugor
authors.forename: D
authors.initials: D
authors.lastname: Krot
authors.forename: R
authors.initials: R
authors.lastname: Kühn
authors.forename: K M
authors.initials: KM
authors.lastname: Schrott
authors.forename: G E
authors.initials: GE
authors.lastname: Schott
mesh_terms: D000293:Adolescent; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D003609:Dactinomycin / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000175:diagnosis* / Q000188:drug therapy*; D016896:Treatment Outcome; D014750:Vincristine / Q000008:administration & dosage; D009396:Wilms Tumor / Q000175:diagnosis* / Q000188:drug therapy*
chemical_list: D003609:Dactinomycin; D014750:Vincristine