title: Oral colon delivery: rationale and time-based drug design strategy.
abstract: Increasing efforts have recently been spent onto the accomplishment of oral colon targeting. Indeed, this has been related to a number of local as well as systemic highly interesting applications, such as a more effective and tolerable therapy of inflammatory bowel disease (IBD), the pharmacological prevention of colorectal adenocarcinoma, and a possible improvement in the oral bioavailability of peptide and protein drugs. For the purpose of colon targeting, a variety of delivery technologies have been described, which rely on typical variation patterns shown by selected physiological parameters throughout the gastrointestinal tract. In particular, this article is focused on time-based formulation approaches that exploit the relative consistency in the small intestinal transit time (SITT) of dosage forms.
authors.affiliation: Istituto di Chimica Farmaceutica e Tossicologica, University of Milan, V.le Abruzzi 42, 20131 Milan, Italy. andrea.gazzaniga@unimi.it
authors.forename: Andrea
authors.initials: A
authors.lastname: Gazzaniga
authors.forename: Alessandra
authors.initials: A
authors.lastname: Maroni
authors.forename: Anastasia
authors.initials: A
authors.lastname: Foppoli
authors.forename: Luca
authors.initials: L
authors.lastname: Palugan
mesh_terms: D000284:Administration, Oral; D000818:Animals; D003106:Colon / Q000378:metabolism* / Q000473:pathology*; D003108:Colonic Diseases / Q000188:drug therapy; D016503:Drug Delivery Systems / Q000379:methods*; D015195:Drug Design; D005772:Gastrointestinal Transit / Q000502:physiology; D006801:Humans; D008954:Models, Biological; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*
chemical_list: D004364:Pharmaceutical Preparations