Lanthanum carbonate: time to abandon prejudices?
Since lanthanum carbonate has become available there has been much interest in its use as a non-calcium-containing phosphate binder, but also much speculation among scientists about possible aluminum-like toxicity. This Commentary focuses on the major aspects of this scientific controversy, confirming the safety and efficacy of this new phosphate binder.
Brancaccio
D
D
Department of Nephrology, University of Milan at San Paolo Hospital, Milan, Italy. diego.brancaccio@unimi.it
Cozzolino
M
M
D000535:Aluminum / Q000633:toxicity; D000818:Animals; D001842:Bone and Bones / Q000378:metabolism; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D006801:Humans; D007811:Lanthanum / Q000009:adverse effects* / Q000493:pharmacokinetics* / Q000633:toxicity; D008099:Liver / Q000378:metabolism; D010710:Phosphates / Q000097:blood; D010760:Phosphorus Metabolism Disorders / Q000188:drug therapy*; D051381:Rats
D010710:Phosphates; C119467:lanthanum carbonate; D007811:Lanthanum; D000535:Aluminum