Primary mediastinal anaplastic alk-1-positive large-cell lymphoma of T/NK-cell type expressing CD20.
We describe an unusual case of ALK-1-positive primary mediastinal lymphoma with the morphology of an anaplastic large-cell lymphoma (ALCL) of T/NK cell type but expressing CD20. This tumour had T/NK morphology and immunophenotype, as demonstrated by its expression of CD30, EMA, ALK-1, CD7 and TiA-1 and the lack of expression of B-cell markers other than CD20. The significance of such a co-expression of a B cell-associated antigen in a case of ALCL of T/NK cell type is discussed.
Gonin
J
J
Service Central d'Anatomie et Cytologie Pathologiques, Jacques Delarue, Hôtel-Dieu, 1, place du parvis Notre-Dame, 75181, Paris Cedex 04, France.
Kadiri
H
H
Bensaci
S
S
Le Tourneau
A
A
Molina
T J
TJ
Diebold
J
J
Abdellouche
D J
DJ
Audouin
J
J
D030301:Activin Receptors, Type II / Q000378:metabolism*; D018951:Antigens, CD20 / Q000378:metabolism*; D014408:Biomarkers, Tumor / Q000378:metabolism; D002648:Child; D006801:Humans; D016130:Immunophenotyping; D007694:Killer Cells, Natural / Q000378:metabolism / Q000473:pathology*; D017728:Lymphoma, Large-Cell, Anaplastic / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008479:Mediastinal Neoplasms / Q000378:metabolism / Q000473:pathology*; D013601:T-Lymphocytes / Q000378:metabolism / Q000473:pathology*
D018951:Antigens, CD20; D014408:Biomarkers, Tumor; C425364:ACVRL1 protein, human; D030301:Activin Receptors, Type II