[Treatment of hydatid cyst in sheep. Assay of a new scolicide].
OBJECTIVE
The main of this study was to show the rapidity of the protoscolicide action of a synthetic compound, dipeptide methyl ester when it is injected under echographic control into hydatid cyst of sheep.


METHODS
Fourthty sheep with hydatid cysts, repaired at echography and punctionable are treated by dipeptide methyl ester injection at the dose of 110 mM.


RESULTS
In vitro tests have allowed to define the efficacy dose of dipeptide methyl ester which is 110 mM. At echography, after injection of the drug, from the first minutes, a detachment of the inner membrane, a diminution of the size of the treated cyst were observed. The cyst content is modified. The sheep autopsy was realized after 4.6.12 and 17 weeks after the injection and showed a size reduction, a treated cyst calcification.


CONCLUSIONS
The dipeptide methyl ester injection into hydatid cyst induces rapidly a morphological alteration, they are calcified. The advantage of this compound is its very rapidity action, this could decrease dissemination risks of hydatid liquid in the organism during operation. Also, this drug permits to reduce the operation time.
Hammou
Azza
A
Département de Radiologie, Hôpital d'Enfants, Bab Saâdoun, Tunis, Tunisie.
Sarciron
Marie-Elisabeth
ME
Lahmar
Samia
S
Ben Chehida
Férid
F
Ghérardi
Arnaud
A
Lahmar
Jamil
J
Hassen
A Gharbi
AG
Pétavy
Anne-Françoise
AF
D000818:Animals; D004151:Dipeptides / Q000494:pharmacology*; D004443:Echinococcosis / Q000000981:diagnostic imaging / Q000188:drug therapy*; D007267:Injections; D012756:Sheep; D018084:Ultrasonography, Interventional
D004151:Dipeptides