The immunomodulation effect of allogenic blood transfusion in colorectal cancer--a new approach.
The total number of 542 patients with colorectal cancer surgery have been analyzed in order to estimate the effect of receiving transfusion local recurrences, and the disease free - survival. It should be examined whether there are changes in general immunity indicators which would be connected with perioperative transfusion. A significant connection has been found between local recurrences and blood transfusion (p<0.0001), the most noticeable being in Dukes A (p =0.045), localization on rectum (p=0.036). The receiving of blood transfusion is linked significantly with disease free - survival reduction (p =0.0068; log rank), the most significant being in Dukes A stage (p =0.0123; log rank) and with localization on rectum (p=0.0231). The analysis of general immunity indicators has shown significant immunocompromitation of patients just before the surgery and this could have effect on immunomodulation caused by transfusion and just as on the treatment prognosis of colorectal carcinoma.
Sabalić
Srećko
S
General County Hospital Pozega, Pozega, Croatia. ssabalic@t-com.hr
Kovacević
Dujo
D
Glavić
Zeljko
Z
Buković
Damir
D
Despot
Albert
A
Fajdić
Josip
J
Lukac
Josip
J
Seso
Ivana
I
D015179:Colorectal Neoplasms / Q000276:immunology* / Q000601:surgery / Q000628:therapy; D018572:Disease-Free Survival; D006801:Humans; D007108:Immune Tolerance; D007111:Immunity, Cellular; D009364:Neoplasm Recurrence, Local; D011379:Prognosis; D065227:Transfusion Reaction