title: A computer model of the pediatric circulatory system for testing pediatric assist devices.
abstract: Lumped parameter computer models of the pediatric circulatory systems for 1- and 4-year-olds were developed to predict hemodynamic responses to mechanical circulatory support devices. Model parameters, including resistance, compliance and volume, were adjusted to match hemodynamic pressure and flow waveforms, pressure-volume loops, percent systole, and heart rate of pediatric patients (n = 6) with normal ventricles. Left ventricular failure was modeled by adjusting the time-varying compliance curve of the left heart to produce aortic pressures and cardiac outputs consistent with those observed clinically. Models of pediatric continuous flow (CF) and pulsatile flow (PF) ventricular assist devices (VAD) and intraaortic balloon pump (IABP) were developed and integrated into the heart failure pediatric circulatory system models. Computer simulations were conducted to predict acute hemodynamic responses to PF and CF VAD operating at 50%, 75% and 100% support and 2.5 and 5 ml IABP operating at 1:1 and 1:2 support modes. The computer model of the pediatric circulation matched the human pediatric hemodynamic waveform morphology to within 90% and cardiac function parameters with 95% accuracy. The computer model predicted PF VAD and IABP restore aortic pressure pulsatility and variation in end-systolic and end-diastolic volume, but diminish with increasing CF VAD support.
authors.affiliation: Cardiovascular Innovation Institute, University of Louisville, Departments of Surgery and Bioengineering, Louisville, Kentucky 40202, USA.
authors.forename: Guruprasad A
authors.initials: GA
authors.lastname: Giridharan
authors.forename: Steven C
authors.initials: SC
authors.lastname: Koenig
authors.forename: Michael
authors.initials: M
authors.lastname: Mitchell
authors.forename: Mark
authors.initials: M
authors.lastname: Gartner
authors.forename: George M
authors.initials: GM
authors.lastname: Pantalos
mesh_terms: D001794:Blood Pressure; D002675:Child, Preschool; D003198:Computer Simulation; D003326:Coronary Circulation; D006339:Heart Rate; D006353:Heart-Assist Devices; D006801:Humans; D007223:Infant; D007423:Intra-Aortic Balloon Pumping; D008955:Models, Cardiovascular; D011673:Pulsatile Flow; D016277:Ventricular Function, Left