title: Summing up 100 years of asthma.
abstract: In this review, we aim to lead the readers through the historical highlights of pathophysiological concepts and treatment of asthma. Understanding the nature and links of asthma has modeled our diagnostic, pathophysiological and therapeutic thinking and acting. The recognition of its heterogeneous nature in combination with several refined and sophisticated technologies will mark a new era of phenotype-specific approach and treatment of asthma.
authors.affiliation: Department of Respiratory and Allergy Research, Centre for Human Drug Research, Leiden, Zernikedreef 10, 2333 CL Leiden, The Netherlands. zdiamant@chdr.nl
authors.forename: Zuzana
authors.initials: Z
authors.lastname: Diamant
authors.forename: J Diderik
authors.initials: JD
authors.lastname: Boot
authors.forename: J Christian
authors.initials: JC
authors.lastname: Virchow
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000318:Adrenergic beta-Agonists / Q000627:therapeutic use; D001249:Asthma / Q000188:drug therapy / Q000209:etiology / Q000266:history*; D001993:Bronchodilator Agents / Q000627:therapeutic use; D018680:Cholinergic Antagonists / Q000627:therapeutic use; D006634:Histamine H1 Antagonists / Q000627:therapeutic use; D049672:History, 19th Century; D049673:History, 20th Century; D006801:Humans; D007665:Ketotifen / Q000627:therapeutic use; D020024:Leukotriene Antagonists / Q000627:therapeutic use; D010641:Phenotype; D014970:Xanthines / Q000627:therapeutic use
chemical_list: D000305:Adrenal Cortex Hormones; D000318:Adrenergic beta-Agonists; D001993:Bronchodilator Agents; D018680:Cholinergic Antagonists; D006634:Histamine H1 Antagonists; D020024:Leukotriene Antagonists; D014970:Xanthines; D007665:Ketotifen