Is Her-2/neu expressed in nonepithelial ovarian malignancies?
OBJECTIVE
The objective of this study was to assess the expression of Her-2/neu in nonepithelial ovarian malignancies.


METHODS
Formalin-fixed paraffin-embedded archival tissue blocks of 20 unselected nonepithelial ovarian malignancies (12 granulosa cell tumors and 8 germ cell tumors) diagnosed between 1993 and 2005 were immunohistochemically stained for Her-2/neu.


RESULTS
Immunohistochemical staining for Her-2/neu was not present in any of these nonepithelial malignancies examined.


CONCLUSIONS
Our limited sample size does not allow a generalized conclusion concerning the lack of Her-2/neu expression in nonepithelial ovarian malignancies, but it adds information with regard to the expression of this oncogene in these rare neoplasms and seems to indicate that it is not a frequent occurrence.
Menczer
Joseph
J
Gynecologic Oncology Unit, Department of Obstetrics and Gynecology, E. Wolfson Medical Center, Holon, Israel.
Schreiber
Letizia
L
Czernobilsky
Bernard
B
Berger
Esther
E
Golan
Abraham
A
Levy
Tally
T
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D018734:Genes, erbB-2 / Q000235:genetics*; D006106:Granulosa Cell Tumor / Q000378:metabolism*; D006801:Humans; D008875:Middle Aged; D009373:Neoplasms, Germ Cell and Embryonal / Q000235:genetics*; D010051:Ovarian Neoplasms / Q000378:metabolism*