Controlling multiple fluorescent signal output in cyclic peptide-based supramolecular systems.
A multicomponent equilibrium network based on self-assembling alpha,gamma-cyclic peptides with controlled fluorescence output is described. The network takes advantage of the large association constant of alpha,gamma-cyclic peptides and the controlled formation homo- and heterodimers, making use for the first time of excimer/FRET effects in conjunction for studying complex interaction networks. In addition, we study the Dapoxyl/pyrene FRET pair for the first time.
Brea
Roberto J
RJ
Departamento de Química OrgAnica, Universidad de Santiago de Compostela, 15782 Santiago de Compostela, Spain.
Vázquez
M Eugenio
ME
Mosquera
Manuel
M
Castedo
Luis
L
Granja
Juan R
JR
D000598:Amino Acids, Cyclic / Q000737:chemistry; D003509:Cyclohexanecarboxylic Acids / Q000737:chemistry; D003517:Cyclopentanes / Q000737:chemistry; D019281:Dimerization; D031541:Fluorescence Resonance Energy Transfer; D008958:Models, Molecular; D010456:Peptides, Cyclic / Q000737:chemistry*; D011721:Pyrenes / Q000737:chemistry; D013050:Spectrometry, Fluorescence / Q000379:methods
D000598:Amino Acids, Cyclic; D003509:Cyclohexanecarboxylic Acids; D003517:Cyclopentanes; D010456:Peptides, Cyclic; D011721:Pyrenes; C015666:3-aminocyclohexanecarboxylic acid; C075501:3-aminocyclopentane-1-carboxylic acid; C030984:pyrene