Morphogens as conserved axon guidance cues.
Morphogen family proteins are now widely appreciated as axon guidance cues. Because their roles as morphogens are highly conserved across phylogeny, their functional conservation in axon guidance is now being rigorously examined. Recent studies suggest that morphogens are important in shaping topographic projections in chick and Drosophila visual systems, a process that occurs even later in development.
Zou
Yimin
Y
Biological Sciences Division Neurobiology Section, University of California, San Diego, 9500 Gilman Drive, Pacific Hall - Room 1220, La Jolla, California 92093, USA. yzou@ucsd.edu
Lyuksyutova
Anna I
AI
D000818:Animals; D019485:Bone Morphogenetic Proteins / Q000378:metabolism; D002454:Cell Differentiation / Q000502:physiology; D003463:Cues; D020439:Growth Cones / Q000378:metabolism* / Q000648:ultrastructure; D053823:Hedgehog Proteins / Q000378:metabolism; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism*; D009414:Nerve Growth Factors / Q000378:metabolism; D009420:Nervous System / Q000196:embryology* / Q000378:metabolism*; D000075388:Netrin-1; D009434:Neural Pathways / Q000196:embryology* / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology; D025521:Tumor Suppressor Proteins / Q000378:metabolism
D019485:Bone Morphogenetic Proteins; D053823:Hedgehog Proteins; D036341:Intercellular Signaling Peptides and Proteins; D009414:Nerve Growth Factors; D025521:Tumor Suppressor Proteins; D000075388:Netrin-1