Antioxidants and CVD in diabetes: where do we stand now.
Diabetes is an oxidative stress disorder as a result of both hyperglycemia and increased levels of free fatty acids. Oxidative stress has been implicated in the pathogenesis of diabetes-related complications, and treatment with antioxidants seemed to be a promising therapeutic option. Although animal studies and preliminary human studies were initially encouraging, subsequent human studies have failed to show a clear benefit of antioxidants, whereas some studies have even suggested that they can be potentially harmful. Therefore, treatment with antioxidants cannot be currently recommended as a therapeutic option.
Yim
Susie
S
Microcirculation Laboratory, Palmer 321A, Beth Israel Deaconess Medical Center, West Campus, One Deaconess Road, Boston, MA, 02215, USA.
Malhotra
Atul
A
Veves
Aristidis
A
D000818:Animals; D000975:Antioxidants / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D002318:Cardiovascular Diseases / Q000150:complications* / Q000188:drug therapy / Q000378:metabolism*; D003920:Diabetes Mellitus / Q000188:drug therapy* / Q000378:metabolism*; D004032:Diet; D004727:Endothelium / Q000187:drug effects / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D018384:Oxidative Stress
D000975:Antioxidants