title: Acetaminophen use and the symptoms of asthma, allergic rhinitis and eczema in children.
abstract: Allergic diseases are frequent in children and their prevalence and severity differ in the different regions of the world. A number of studies have been performed to determine the factors which are effective in the incidence of these diseases. One of the drugs that might have a role in incidence or intensity of the symptoms of allergic diseases is Acetaminophen. In our survey conducted with standardized method (International Study of Asthma and Allergies in Childhood), 3000 children 6-7 years old and 3000 teenagers 13-14 years old were questioned regarding asthma, allergic rhinitis and eczema. The prevalence of ever wheezing in the children of 6-7 years old who took acetaminophen in the first year of their life was 11.3%, which is more than other group (Odds Ratio=1.54, 95% Confidence Interval: 1-2.38, P=0.049) and the prevalence of ever wheezing in older age group who have taken acetaminophen at least once in a month was 25.1% which is more than those taken less acetaminophen (OR=1.7, 95%CI=1.43-2.04, P=0.000). Moreover taking more acetaminophen during past 12 months led to more prevalence of night dry coughs and the symptoms of rhinitis in children 6-7 years old and eczema and rhinitis symptoms in the 13-14 years old. Our findings suggest that taking more acetaminophen may be associated with increasing allergic symptoms in children.
authors.affiliation: Department of Pediatrics, School of Medicine, Shahid Sadoughi University Of Medical Sciences and Health Services, Yazd, Iran. mehrankarimi1@hotmail.com
authors.forename: Mehran
authors.initials: M
authors.lastname: Karimi
authors.forename: Mohsen
authors.initials: M
authors.lastname: Mirzaei
authors.forename: Mohammad Hossein
authors.initials: MH
authors.lastname: Ahmadieh
mesh_terms: D000082:Acetaminophen / Q000009:adverse effects*; D000293:Adolescent; D018712:Analgesics, Non-Narcotic / Q000009:adverse effects*; D001249:Asthma / Q000453:epidemiology*; D002648:Child; D004305:Dose-Response Relationship, Drug; D004485:Eczema / Q000139:chemically induced / Q000453:epidemiology* / Q000473:pathology; D006801:Humans; D012221:Rhinitis, Allergic, Perennial / Q000139:chemically induced / Q000453:epidemiology* / Q000473:pathology; D006255:Rhinitis, Allergic, Seasonal / Q000139:chemically induced / Q000453:epidemiology* / Q000473:pathology; D012307:Risk Factors
chemical_list: D018712:Analgesics, Non-Narcotic; D000082:Acetaminophen