[Experimental study of aero-otitis media].
OBJECTIVE
To establish the animal model of aero-otitis media.


METHODS
Thirty healthy guinea-pigs were selected and PVC tube was placed from left nasal cavity to nasopharynx for 7 days. Hypobaric chamber experiment was performed before and after tube placement, and also after the treatment. Eardrum examination and tympanogram were carried out each time before and after the hypobaric chamber experiment.


RESULTS
(1)The inflammation of nasal cavity, nasal sinuses and nasopharynx could be seen on CT after PVC tube placement. After treatment, the inflammation subsidised. (2) There was significant difference in left eardrum and tympanogram before and after tube placement, as well as after tube placement and after treatment. Significant difference could also be seen between left ear and right ear after the tube placement.


CONCLUSIONS
The animal model in this study may provide reference in diagnosis, classification, treatment and health evaluation of earo-otitis media in pilots.
Xu
Xianrong
X
The Center of Clinical Aviation Medicine, PLA, General Hospital of Air Force, Beijing, 100036, China. xuxianrongkz@sina.com
Zhang
Yang
Y
Jin
Zhanguo
Z
Chen
Jun
J
Zhang
Suhong
S
D000818:Animals; D001359:Aviation; D004195:Disease Models, Animal; D004432:Ear, Middle / Q000473:pathology*; D006168:Guinea Pigs; D008297:Male; D010033:Otitis Media / Q000209:etiology* / Q000473:pathology*