title: UV-B irradiation attenuates dermal effects of botulinum toxin A: a randomized, double-blind, placebo-controlled study.
abstract: BACKGROUND
  Botulinum toxin type A (BoNT/A) is frequently used for cosmetic indications and hyperhidrosis.
  
  
  OBJECTIVE
  We investigated whether UV-B irradiation alleviates the BoNT/A effect on local sudomotor activity.
  
  
  METHODS
  In a randomized, double-blinded trial, the anhidrotic areas after BoNT/A (100 mU) injection 48 hours before and 14 days after UV-B irradiation were compared in six healthy volunteers.
  
  
  RESULTS
  UV-B irradiation alleviated BoNT/A effect by approximately 30% (p=.0017). The UV-B-evoked reduction of anhidrotic areas was constant over the observation period of 14 weeks.
  
  
  CONCLUSIONS
  When BoNT/A is applied intradermally, excessive exposure to UV-B and sunburn should be reconsidered. The authors have indicated no significant interest with commercial supporters.
authors.affiliation: Department of Neurology, Medical University of Vienna, Vienna, Austria. thomas.sycha@meduniwien.ac.at
authors.forename: Thomas
authors.initials: T
authors.lastname: Sycha
authors.forename: Nicole
authors.initials: N
authors.lastname: Kotzailias
authors.forename: Gottfried
authors.initials: G
authors.lastname: Kranz
authors.forename: Franz
authors.initials: F
authors.lastname: Trautinger
authors.forename: Peter
authors.initials: P
authors.lastname: Schnider
authors.forename: Eduard
authors.initials: E
authors.lastname: Auff
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D019274:Botulinum Toxins, Type A / Q000008:administration & dosage / Q000494:pharmacology; D004311:Double-Blind Method; D009465:Neuromuscular Agents / Q000008:administration & dosage / Q000494:pharmacology; D014466:Ultraviolet Rays / Q000009:adverse effects
chemical_list: D019274:Botulinum Toxins, Type A; D009465:Neuromuscular Agents