title: Genetic screening for signal transduction in the era of network biology.
abstract: In contrast to animal-based mutant phenotype assays, recent biochemical and quantitative genetic studies have identified hundreds of potential regulators of known signaling pathways. We discuss the discrepancy between previous models and new data, put forward a different signaling conceptual framework incorporating time-dependent quantitative contributions, and suggest how this new framework can impact our study of human disease.
authors.affiliation: Department of Genetics, Howard Hughes Medical Institute, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02175, USA.
authors.forename: Adam
authors.initials: A
authors.lastname: Friedman
authors.forename: Norbert
authors.initials: N
authors.lastname: Perrimon
mesh_terms: D000818:Animals; D019295:Computational Biology / Q000379:methods / Q000639:trends; D005786:Gene Expression Regulation / Q000235:genetics; D053263:Gene Regulatory Networks / Q000235:genetics*; D030342:Genetic Diseases, Inborn / Q000235:genetics / Q000503:physiopathology / Q000628:therapy; D005820:Genetic Testing / Q000379:methods* / Q000639:trends; D006801:Humans; D008967:Molecular Biology / Q000379:methods* / Q000639:trends; D009369:Neoplasms / Q000628:therapy; D015398:Signal Transduction / Q000235:genetics*