Children's vaccines do not induce cross reactivity against SARS-CoV.
In contrast with adults, children infected by severe acute respiratory syndrome-corona virus (SARS-CoV) develop milder clinical symptoms. Because of this, it is speculated that children vaccinated with various childhood vaccines might develop cross immunity against SARS-CoV. Antisera and T cells from mice immunised with various vaccines were used to determine whether they developed cross reactivity against SARS-CoV. The results showed no marked cross reactivity against SARS-CoV, which implies that the reduced symptoms among children infected by SARS-CoV may be caused by other factors.
Yu
Yang
Y
State Key Laboratory for Agro-Biotechnology, College of Biological Science, China Agricultural University, Beijing, China.
Jin
Huali
H
Chen
Ze
Z
Yu
Qingling L
QL
Ma
Yijie J
YJ
Sun
Xiaolin L
XL
Wang
Bin
B
D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D002648:Child; D002675:Child, Preschool; D003429:Cross Reactions / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D006801:Humans; D007106:Immune Sera / Q000276:immunology; D007114:Immunization; D007223:Infant; D051379:Mice; D008810:Mice, Inbred C57BL; D045473:Severe acute respiratory syndrome-related coronavirus / Q000276:immunology*; D045169:Severe Acute Respiratory Syndrome / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology; D014612:Vaccines / Q000276:immunology*
D000914:Antibodies, Viral; D007106:Immune Sera; D014612:Vaccines