title: Effect of glucagon-like peptide-1 and -2 on regulation of food intake, body temperature and locomotor activity in the Japanese quail.
abstract: To investigate the physiological roles of glucagon-like peptide-1 (GLP-1) and glucagon-like peptide-2 (GLP-2) in avian species, we elucidated the effect of intraperitoneal (i.p.) and intracerebroventricular (i.c.v.) administration of GLP-1 and GLP-2 on food intake, body temperature and gross locomotor activity in adult Japanese quail. Both i.p. and i.c.v. administration of GLP-1 suppressed food intake at 2, 4 and 12h after administration. Moreover, both i.p. and i.c.v. administration of GLP-1 significantly decreased both body temperature and gross locomotor activity 2h after administration. On the other hand, both i.p. and i.c.v. administration of GLP-2 had no effect on food intake, body temperature or gross locomotor activity. These results suggest that GLP-1 may have an important role in the regulation of food intake, body temperature and locomotor activity while GLP-2 may have no apparent effect on feeding regulation in adult Japanese quail.
authors.affiliation: Department of Veterinary Physiology, Faculty of Agriculture, University of Miyazaki, Miyazaki 889-2155, Japan.
authors.forename: Saad
authors.initials: S
authors.lastname: Shousha
authors.forename: Keiko
authors.initials: K
authors.lastname: Nakahara
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Nasu
authors.forename: Takumi
authors.initials: T
authors.lastname: Sakamoto
authors.forename: Noboru
authors.initials: N
authors.lastname: Murakami
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001831:Body Temperature / Q000187:drug effects*; D003370:Coturnix / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D004435:Eating / Q000187:drug effects*; D052216:Glucagon-Like Peptide 1 / Q000494:pharmacology*; D053767:Glucagon-Like Peptide 2 / Q000494:pharmacology*; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D013997:Time Factors
chemical_list: D053767:Glucagon-Like Peptide 2; D052216:Glucagon-Like Peptide 1