RK-95113, a new angiogenesis inhibitor produced by Aspergillus fumigatus.
We found that the strain Aspergillus fumigatus var. fumigatus RK95-113 produced a new angiogenesis inhibitor, RK-95113. Spectroscopic analyses identified the structure of RK-95113 as a new fumagillin-related small molecule. RK-95113 preferentially inhibited the growth of human umbilical vein endothelial cells (HUVECs) rather than that of human normal fibroblasts in cell proliferation assays and blocked endothlial cell migration induced by vascular endothelial growth factor (VEGF).
Asami
Yukihiro
Y
Antibiotics Laboratory, Discovery Research Institute, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.
Kakeya
Hideaki
H
Okada
Gen
G
Toi
Masakazu
M
Osada
Hiroyuki
H
D020533:Angiogenesis Inhibitors / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D001232:Aspergillus fumigatus / Q000737:chemistry / Q000378:metabolism; D048708:Cell Growth Processes / Q000187:drug effects; D002465:Cell Movement / Q000187:drug effects; D042783:Endothelial Cells / Q000166:cytology / Q000187:drug effects; D004852:Epoxy Compounds / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D005285:Fermentation; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects; D006801:Humans; D019906:Nuclear Magnetic Resonance, Biomolecular; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
D020533:Angiogenesis Inhibitors; D004852:Epoxy Compounds; C517258:RK-95113; D012717:Sesquiterpenes