Isolation and structure elucidation of neofusapyrone from a marine-derived Fusarium species, and structural revision of fusapyrone and deoxyfusapyrone.
Three polyketides containing a pyrone ring, neofusapyrone, fusapyrone, and deoxyfusapyrone, were isolated from the marine-derived fungus Fusarium sp. FH-146. Their structures were determined by extensive ID- and 2D-NMR and MS spectral analyses. Fusapyrone and deoxyfusapyrone were originally reported as a-pyrone derivatives; however, the revised structures indicate that they are gamma-pyrone derivatives. These three compounds exhibited antimicrobial activities.
Hiramatsu
Fuminori
F
Department of Bioresource Engineering, Faculty of Agriculture, Yamagata University, Tsuruoka, Yamagata 997-8555, Japan.
Miyajima
Takeshi
T
Murayama
Tetsuya
T
Takahashi
Koetsu
K
Koseki
Takuya
T
Shiono
Yoshihito
Y
D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001230:Aspergillus / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D005285:Fermentation; D005670:Fusarium / Q000737:chemistry* / Q000378:metabolism; D008826:Microbial Sensitivity Tests; D019906:Nuclear Magnetic Resonance, Biomolecular; D009904:Optical Rotation; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D011753:Pyrones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013211:Staphylococcus aureus / Q000187:drug effects
D000890:Anti-Infective Agents; D011753:Pyrones; C088397:fusapyrone