Association of vascular endothelial growth factor gene polymorphism with myocardial infarction in patients with type 2 diabetes.
BACKGROUND
Many studies have reported increased serum levels of vascular endothelial growth factor (VEGF) in patients with acute coronary syndromes. We searched for the association between either the -634 C/G or the insertion/deletion (I/D) polymorphism of the VEGF gene and myocardial infarction (MI) in subjects with type 2 diabetes.


METHODS
143 subjects with type 2 diabetes and MI were compared to 228 diabetic subjects without coronary artery disease (CAD). VEGF serum levels were analyzed in 94 subjects with type 2 diabetes without CAD.


RESULTS
A significantly higher frequency of the CC genotype of the -634 C/G VEGF polymorphism was found in the patients with MI compared to the patients without CAD (17.5 vs. 9.2%; p = 0.019), whereas the insertion/deletion VEGF polymorphism failed to yield an association with MI. Significantly higher VEGF serum levels were demonstrated in subjects with the CC genotype compared to those with the other (CG + GG) genotypes (60.4 +/- 32.1 vs. 44.1 +/- 23.5 ng/l; p < 0.01).


CONCLUSIONS
The present study demonstrates that the CC genotype of the -634 C/G VEGF gene might be a risk factor for MI in Caucasians with type 2 diabetes of duration of more than 10 years.
Petrovic
Daniel
D
Institute of Histology and Embryology, Medical Faculty, University of Ljubljana, Ljubljana, Slovenia. daniel.petrovic@mf.uni-lj.si
Verhovec
Renata
R
Globocnik Petrovic
Mojca
M
Osredkar
Josko
J
Peterlin
Borut
B
D000368:Aged; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000150:complications / Q000235:genetics*; D011110:Polymorphism, Genetic; D012307:Risk Factors; D017524:Slovenia; D042461:Vascular Endothelial Growth Factor A / Q000097:blood / Q000235:genetics*
C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A