Translational dysregulation by Pateamine A.
Pateamine A inhibits translation by preventing proper translational initiation complex formation. In the December issue of Chemistry & Biology, Bordeleau et al. demonstrated that the effects of Patemine A on translation are mediated through the interaction between the RNA helicase eIF4A and mRNA .
Korneeva
Nadejda L
NL
Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130-3932, USA. nkorne@lsuhsc.edu
D000970:Antineoplastic Agents / Q000494:pharmacology; D004852:Epoxy Compounds / Q000494:pharmacology*; D039601:Eukaryotic Initiation Factor-4A / Q000037:antagonists & inhibitors / Q000378:metabolism; D018942:Macrolides / Q000494:pharmacology*; D011485:Protein Binding / Q000187:drug effects; D014176:Protein Biosynthesis / Q000187:drug effects*; D012333:RNA, Messenger / Q000378:metabolism; D016601:RNA-Binding Proteins; D013844:Thiazoles / Q000494:pharmacology*
D000970:Antineoplastic Agents; D004852:Epoxy Compounds; D018942:Macrolides; D012333:RNA, Messenger; D016601:RNA-Binding Proteins; D013844:Thiazoles; C421324:pateamine A; D039601:Eukaryotic Initiation Factor-4A