title: One-pot approach to chiral chromenes via enantioselective organocatalytic domino oxa-Michael-aldol reaction.
abstract: A highly enantioselective (S)-diphenylpyrrolinol triethylsilyl ether promoted tandem oxa-Michael-aldol reaction of alpha,beta-unsaturated aldehydes with salicylaldehydes has been developed; the method affords one-pot access to chiral and synthetically useful chromenes in high yields and high enantioselectivities from readily available compounds.
authors.affiliation: Department of Chemistry, University of New Mexico, Albuquerque, NM 87131, USA.
authors.forename: Hao
authors.initials: H
authors.lastname: Li
authors.forename: Jian
authors.initials: J
authors.lastname: Wang
authors.forename: Timiyin
authors.initials: T
authors.lastname: E-Nunu
authors.forename: Liansuo
authors.initials: L
authors.lastname: Zu
authors.forename: Wei
authors.initials: W
authors.lastname: Jiang
authors.forename: Shaohua
authors.initials: S
authors.lastname: Wei
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
mesh_terms: D000171:Acrolein / Q000031:analogs & derivatives* / Q000737:chemistry; D000447:Aldehydes / Q000737:chemistry*; D001578:Benzopyrans / Q000138:chemical synthesis*; D002384:Catalysis; D002625:Chemistry, Organic / Q000379:methods*; D013237:Stereoisomerism
chemical_list: D000447:Aldehydes; D001578:Benzopyrans; C013243:salicylaldehyde; D000171:Acrolein; C012843:cinnamaldehyde