A facile two-step synthesis of 8-arylated guanosine mono- and triphosphates (8-aryl GXPs).
We report a simple and high-yielding two-step procedure for the preparation of 8-arylated guanosine mono- and triphosphates (8-aryl GXPs). The key step of our synthesis is the Suzuki-Miyaura coupling of unprotected 8-bromo GMP and 8-bromo GTP with various arylboronic acids in aqueous solution. The 8-bromoguanosine 5'-phosphates required as cross-coupling substrates were prepared from 8-bromoguanosine via an optimised Yoshikawa procedure.
Collier
Alice
A
Centre for Carbohydrate Chemistry, School of Chemical Sciences and Pharmacy, University of East Anglia, Norwich, UKNR4 7TJ.
Wagner
Gerd
G
D006151:Guanosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis*; D015394:Molecular Structure
D006151:Guanosine