title: Nine-year changes in cardiovascular disease risk factors with weight maintenance in the atherosclerosis risk in communities cohort.
abstract: Few studies have focused on the impact of weight maintenance on cardiovascular disease risk factors or addressed whether changes differ by baseline weight status and medication usage. The authors examined these issues using 9 years of follow-up data on 3,235 men and women from the Atherosclerosis Risk in Communities (ARIC) Study who were aged 45-64 years at baseline (1987-1989). In participants not using medications, glucose (3.0 mg/dl, 95% confidence interval (CI): 2.4, 3.5) and triglycerides (10.1 mg/dl, 95% CI: 8.3, 11.9) increased, while total cholesterol (-9.6 mg/dl, 95% CI: -10.6, -8.6), low density lipoprotein cholesterol (-9.9 mg/dl, 95% CI: -10.9, -9.0), and high density lipoprotein cholesterol (-1.7 mg/dl, 95% CI: -2.1, -1.3) decreased. Systolic blood pressure (7.9 mmHg, 95% CI: 7.3, 8.4) increased, but diastolic blood pressure (-1.1 mmHg, 95% CI: -1.4, -0.7) declined. Normal weight (body mass index: 18.5-<25.0 kg/m(2)) participants had smaller increases in glucose compared with obese (body mass index: >/=30.0 kg/m(2)) participants. In contrast, the authors found less favorable changes in total, low density lipoprotein, and high density lipoprotein cholesterol, triglycerides, and diastolic blood pressure among normal weight compared with obese participants who maintained their weight. These patterns were similar across weight status groups regardless of medication usage.
authors.affiliation: Department of Nutrition, School of Public Health, University of North Carolina, Chapel Hill, NC, USA. Kim_Truesdale@unc.edu
authors.forename: Kimberly P
authors.initials: KP
authors.lastname: Truesdale
authors.forename: June
authors.initials: J
authors.lastname: Stevens
authors.forename: Jianwen
authors.initials: J
authors.lastname: Cai
mesh_terms: D000959:Antihypertensive Agents / Q000627:therapeutic use*; D050197:Atherosclerosis / Q000517:prevention & control*; D001794:Blood Pressure; D001835:Body Weight; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D000960:Hypolipidemic Agents / Q000627:therapeutic use*; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors
chemical_list: D000959:Antihypertensive Agents; D000960:Hypolipidemic Agents; D008074:Lipoproteins