title: Efficacy of autologous peripheral blood stem cell transplantation in POEMS syndrome with polyneuropathy.
abstract: POEMS syndrome (POEMS) is a rare multi-system disease which is typically associated with polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy and skin changes. We report herein a case of POEMS with progressive polyneuropathy resistant to high-dose intravenous immunoglobulin therapy who experienced improvement in polyneuropathy after the administration of high-dose chemotherapy followed by autologous peripheral blood stem cell transplantation. Improvements in polyneuropathy remain despite recognition of monoclonal gammopathy by immunofixation as of 1 year after treatment. We demonstrated that autologous peripheral blood stem cell transplantation can improve clinical symptoms and signs due to polyneuropathy in POEMS even without achieving complete remission.
authors.affiliation: The Department of Neurology, Shizuoka Red Cross Hospital. nboimai@ac.mbn.or.jp
authors.forename: Noboru
authors.initials: N
authors.lastname: Imai
authors.forename: Eiji
authors.initials: E
authors.lastname: Kitamura
authors.forename: Takayoshi
authors.initials: T
authors.lastname: Tachibana
authors.forename: Takashi
authors.initials: T
authors.lastname: Konishi
authors.forename: Youji
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Masahiro
authors.initials: M
authors.lastname: Serizawa
authors.forename: Takashi
authors.initials: T
authors.lastname: Okabe
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Fujita
mesh_terms: D003520:Cyclophosphamide / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008875:Middle Aged; D016878:POEMS Syndrome / Q000628:therapy*; D036102:Peripheral Blood Stem Cell Transplantation; D016896:Treatment Outcome
chemical_list: D007166:Immunosuppressive Agents; D003520:Cyclophosphamide