title: Cell biological and molecular characteristics of pseudorabies virus infections in cell cultures and in pigs with emphasis on the respiratory tract.
abstract: In the present review, several cell biological and molecular aspects of virus-cell and virus-host (pig) interactions are reviewed for pseudorabies (Aujeszky's disease) virus. Concerning the virus-cell interactions, the complex cascade of events in the virus replication cycle is given together with the different mechanisms of cell-to-cell spread. The pathogenesis of pseudorabies virus infections in pigs is concentrated on the sequence of events in the respiratory tract. Finally, a short overview is given on the control of the disease and eradication of the virus by the combination of marker vaccines and discriminating ELISA.
authors.affiliation: Laboratory of Virology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium. hans.nauwynck@ugent.be
authors.forename: Hans
authors.initials: H
authors.lastname: Nauwynck
authors.forename: Sarah
authors.initials: S
authors.lastname: Glorieux
authors.forename: Herman
authors.initials: H
authors.lastname: Favoreel
authors.forename: Maurice
authors.initials: M
authors.lastname: Pensaert
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D011558:Herpesvirus 1, Suid / Q000502:physiology*; D011557:Pseudorabies / Q000473:pathology* / Q000821:virology*; D012137:Respiratory System / Q000473:pathology* / Q000821:virology*; D013552:Swine / Q000821:virology; D013553:Swine Diseases / Q000378:metabolism / Q000473:pathology* / Q000821:virology*