Solubilization of saponins of Bupleuri radix with ginseng saponins: cooperative effect of dammarane saponins.
It has been found that the water solubilities of saikosaponins, the active principles of Bupleuri radix, are greatly increased in the presence of ginsenoside-Ro, the glucuronide bisdesmoside of oleanolic acid of Ginseng. No solubilizing effect was observed with the neutral dammarane Saponins of Ginseng. However, the solubilizing effect of ginsenoside-Ro was significantly potentiated in the presence of the dammarane saponins of 20 ( S)-protopanaxadiol. The relationship between the solubilizing effect and the structure of ginsenoside-Ro was also investigated, elucidating the important role of the glucuronide moiety.
Watanabe
K
K
Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine, Kasumi, Minami-ku, Hiroshima Japan.
Fujino
H
H
Morita
T
T
Kasai
R
R
Tanaka
O
O