Dynamics of HIV viral load in blood and semen of patients under HAART: impact of therapy in assisted reproduction procedures.
We examined the efficacy and effect of HAART in HIV-1-infected men confronted with assisted fertilization procedures. We showed that HAART did not always reduce the HIV-1-RNA level in blood and semen compartments, and that a significant upward shift in mitochondrial DNA was observed in spermatozoa from a HAART-treated patient group compared with spermatozoa from HAART-untreated or HIV-1-uninfected groups (P < 0.001). These findings emphasize the negative role of HAART, but not of HIV-1 infection, in determining semen alterations.
La Sala
Giovanni Battista
GB
Division of Obstetrics, Gynecology and Reproduction Medicine, ASMN Reggio Emilia, Italy.
Pilotti
Elisabetta
E
Nicoli
Alessia
A
Pinelli
Silvana
S
Villani
Maria Teresa
MT
Ronzi
Paola
P
Zendri
Enrico
E
Re
Maria Carla
MC
Magnani
Giacomo
G
Casoli
Claudio
C
D019380:Anti-HIV Agents / Q000627:therapeutic use*; D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D015658:HIV Infections / Q000188:drug therapy / Q000276:immunology / Q000821:virology*; D015497:HIV-1 / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D012367:RNA, Viral / Q000032:analysis; D027724:Reproductive Techniques, Assisted; D012661:Semen / Q000821:virology*; D013094:Spermatozoa / Q000821:virology; D016896:Treatment Outcome; D019562:Viral Load; D014779:Virus Replication / Q000187:drug effects
D019380:Anti-HIV Agents; D012367:RNA, Viral