Synthesis and evaluation of (S)-2-ethoxy-3-phenylpropanoic acid derivatives as insulin-sensitizing agents.
A series of (S)-2-ethoxy-3-phenylpropanoic acid derivatives were synthesized and their insulin-sensitizing activities were evaluated in 3T3-L1 cells. Compounds 1b and 1d exhibited more potent insulin-sensitizing activity than rosiglitazone.
Cai
Xiaohua
X
Department of Pharmaceuticals, HuaiHua Medical College, Huaihua 418000, PR China. caixh1111@163.com
Xie
Bing
B
Guo
Hui
H
D041721:3T3-L1 Cells; D000818:Animals; D007004:Hypoglycemic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D007328:Insulin / Q000494:pharmacology*; D051379:Mice; D010666:Phenylpropionates / Q000138:chemical synthesis* / Q000494:pharmacology*; D000077154:Rosiglitazone; D045162:Thiazolidinediones / Q000494:pharmacology
D007004:Hypoglycemic Agents; D007328:Insulin; D010666:Phenylpropionates; D045162:Thiazolidinediones; D000077154:Rosiglitazone