[Spanish cohort of naïve HIV-infected patients (CoRIS): rationale, organization and initial results].
OBJECTIVE
To describe the methodology and baseline results of the Spanish cohort of naïve HIV-infected patients included in the Research Network on HIV/AIDS (CoRIS).


METHODS
CoRIS is a multicenter, hospital-based prospective cohort of HIV sero-prevalent, retroviral-naïve subjects, over 13 years old, and seen at 17 hospitals in 8 of the 17 Autonomous Regions in Spain from January 2004 to October 2005. The socio-demographic characteristics, as well as epidemiological, clinical, laboratory and treatment data were recorded, and biological samples were collected at baseline and during follow-up.


RESULTS
A total of 1,591 subjects have been included in CoRIS; 24% are women, median age at cohort entry is 36 years, and 74% were diagnosed during 2004 or 2005. Twenty-seven percent came from countries other than Spain, mainly Latin-America (16%) and sub-Saharan Africa (5%). Thirty-two percent had completed secondary education and 16% university studies. The most frequent categories of transmission were men having sex with men (37%) and heterosexual sex (36%); only 21% were injection drug users. At cohort entry, median CD4 count was 317 cells/mm 3 and median viral load was 52,300 copies/mL; 18% were diagnosed with AIDS. Main AIDS-defining illnesses were Pneumocystis jiroveci pneumonia (6.1%), esophageal candidiasis (3.3%) and tuberculosis (extrapulmonary, 3.0% and pulmonary 2.7%). There were 35 deaths (2.2%). Thirty-three percent of patients gave a baseline sample to the BioBank.


CONCLUSIONS
CoRIS offers relevant information about the current epidemiological profile of HIV infection in Spain, where sexual transmission has become predominant. The type and amount of information obtained from clinical and epidemiological data collection together with biological samples demonstrate the viability of the project, which offers many possibilities for future research.
Caro-Murillo
Ana María
AM
Centro Nacional de Epidemiología, Instituto de Salud Carlos III, Madrid, Spain. amcaro@isciii.es
Castilla
Jesús
J
Pérez-Hoyos
Santiago
S
Miró
José M
JM
Podzamczer
Daniel
D
Rubio
Rafael
R
Riera
Melchor
M
Viciana
Pompeyo
P
López Aldeguer
José
J
Iribarren
José Antonio
JA
de los Santos-Gil
Ignacio
I
Gómez-Sirvent
Juan Luis
JL
Berenguer
Juan
J
Gutiérrez
Félix
F
Saumoy
María
M
Segura
Ferrán
F
Soriano
Vicente
V
Peña
Alejandro
A
Pulido
Federico
F
Oteo
José Antonio
JA
Leal
Manuel
M
Casabona
Jordi
J
del Amo
Julia
J
Moreno
Santiago
S
D017088:AIDS-Related Opportunistic Infections / Q000453:epidemiology; D000293:Adolescent; D000328:Adult; D017954:Africa South of the Sahara / Q000453:epidemiology; D000368:Aged; D018791:CD4 Lymphocyte Count; D002177:Candidiasis / Q000453:epidemiology; D015331:Cohort Studies; D004522:Educational Status; D005260:Female; D015658:HIV Infections / Q000453:epidemiology* / Q000635:transmission; D006801:Humans; D007843:Latin America / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D011020:Pneumonia, Pneumocystis / Q000453:epidemiology; D011446:Prospective Studies; D012307:Risk Factors; D012725:Sexual Behavior / Q000706:statistics & numerical data; D013030:Spain / Q000453:epidemiology; D015819:Substance Abuse, Intravenous / Q000453:epidemiology; D014376:Tuberculosis / Q000453:epidemiology