title: Physical mapping of the IGF2 locus in the South American opossum Monodelphis domestica.
abstract: The South American opossum Monodelphis domestica has been a model organism for marsupials for many years and has recently been the subject of a large-scale genome sequencing effort that will provide the foundation for comparative studies of gene function and regulation. Genomic imprinting is one mechanism of gene regulation that has received increasing attention due to the impact of imprinting defects on development and disease. We have mapped the imprinted insulin-like growth factor II (IGF2) gene of M. domestica as a first step in understanding the regulatory mechanisms involved in genomic imprinting in this marsupial.
authors.affiliation: Department of Molecular and Cell Biology University of Connecticut, Storrs, CT 06269, USA.
authors.forename: B R
authors.initials: BR
authors.lastname: Lawton
authors.forename: C
authors.initials: C
authors.lastname: Obergfell
authors.forename: R J
authors.initials: RJ
authors.lastname: O'Neill
authors.forename: M J
authors.initials: MJ
authors.lastname: O'Neill
mesh_terms: D000818:Animals; D002874:Chromosome Mapping; D005347:Fibroblasts / Q000378:metabolism; D015723:Gene Library; D016678:Genome; D018392:Genomic Imprinting; D017404:In Situ Hybridization, Fluorescence; D007328:Insulin / Q000378:metabolism; D007335:Insulin-Like Growth Factor II / Q000235:genetics*; D008297:Male; D048309:Monodelphis; D020161:Physical Chromosome Mapping
chemical_list: D007328:Insulin; D007335:Insulin-Like Growth Factor II