Orthopaedic complications associated with sickle-cell disease.
Sickle cell disease is the most frequent haemoglobinopathy in the world. It affects mostly African descent, but is also present in whites in Greece, Turkey, Italy and India. The responsible gene is autosomal co-dominant and only individuals homozygous for the gene are symptomatic. The condition is characterised by haemolytic anaemia crises and cardio-pulmonary, digestive, neurological, ocular and osteo-articular manifestations. Osteo-articular complications are frequent and may compromise harmonious growth. This retrospective study reports the osteo-articular complications associated with sickle-cell disease encountered in our institution from 1975 to 2004. Orthopaedic complications were reported in 79 patients out of 325 who were followed with sickle-cell disease.
de Gheldere
Antoine
A
Department of Orthopaedic Surgery, Cliniques universitaires Saint-Luc, UCL, Brussels, Belgium.
Ndjoko
Roger
R
Docquier
Pierre-Louis
PL
Mousny
Maryline
M
Rombouts
Jean-Jacques
JJ
D000293:Adolescent; D000328:Adult; D000755:Anemia, Sickle Cell / Q000150:complications*; D001847:Bone Diseases / Q000209:etiology*; D001850:Bone Diseases, Infectious / Q000209:etiology; D005260:Female; D005271:Femur Head Necrosis / Q000209:etiology; D006801:Humans; D006811:Humerus / Q000473:pathology; D008297:Male; D010020:Osteonecrosis / Q000000981:diagnostic imaging / Q000209:etiology; D011859:Radiography; D012189:Retrospective Studies