Prostate cancer risk among users of finasteride and alpha-blockers - a population based case-control study.
Finasteride has been reported to reduce prostate cancer risk in asymptomatic men. However, in clinical practice finasteride and alpha-blockers are used to treat benign prostatic hyperplasia (BPH). We evaluated prostate cancer risk among users of BPH pharmacotherapy at the population level. Comprehensive Finnish national registries provided information on 24723 prostate cancer cases and controls. Overall, prostate cancer risk was elevated among users of both drug categories compared to non-users (odds ratio, OR=1.41; 95% confidence interval, CI 1.31-1.51 for finasteride and OR=1.79; 95% CI 1.67-1.91 for alpha-blockers). However, the risk was lower among finasteride users when compared with alpha-blocker users (OR=0.80; 95% CI 0.64-1.00). Regular finasteride users had the lowest risk. The increased risk is probably due to enhanced diagnostics of prostate cancer in men with BPH. Finasteride use does not decrease prostate cancer incidence compared with non-users. Nevertheless, the risk is lower when compared with alpha-blocker users.
Murtola
Teemu J
TJ
University of Tampere, School of Public Health, 33014 Tampere, Finland. teemu.murtola@uta.fi
Tammela
Teuvo L J
TL
Määttänen
Liisa
L
Hakama
Matti
M
Auvinen
Anssi
A
D000317:Adrenergic alpha-Antagonists / Q000009:adverse effects*; D016022:Case-Control Studies; D004791:Enzyme Inhibitors / Q000009:adverse effects*; D018120:Finasteride / Q000009:adverse effects*; D006801:Humans; D008297:Male; D016017:Odds Ratio; D011470:Prostatic Hyperplasia / Q000188:drug therapy*; D011471:Prostatic Neoplasms / Q000139:chemically induced*; D012307:Risk Factors
D000317:Adrenergic alpha-Antagonists; D004791:Enzyme Inhibitors; D018120:Finasteride