title: Acupressure on the extra 1 acupoint: the effect on bispectral index, serum melatonin, plasma beta-endorphin, and stress.
abstract: BACKGROUND
  Acupressure on the "extra 1" point decreases bispectral index (BIS) values and stress.
  
  
  METHODS
  We investigated the BIS, melatonin, beta-endorphin, and verbal stress score values before, after 10 min of acupressure application on the extra 1 point, on a sham point, after no acupressure, and 1 h after completion of each intervention in 12 volunteers.
  
  
  RESULTS
  The BIS and verbal stress score values were decreased after acupressure on the extra 1 point (P = 0.0001 and P = 0.008, respectively), but melatonin and beta-endorphin did not change.
  
  
  CONCLUSIONS
  Acupressure on the extra 1 point has no effect on melatonin and beta-endorphin levels.
authors.affiliation: Department of Anesthesiology, Aretaieio Hospital, Medical School, Athens, Greece. afassou1@otenet.gr
authors.forename: Argyro
authors.initials: A
authors.lastname: Fassoulaki
authors.forename: Anteia
authors.initials: A
authors.lastname: Paraskeva
authors.forename: Georgia
authors.initials: G
authors.lastname: Kostopanagiotou
authors.forename: Eleftheria
authors.initials: E
authors.lastname: Tsakalozou
authors.forename: Sophia
authors.initials: S
authors.lastname: Markantonis
mesh_terms: D019050:Acupressure / Q000379:methods*; D015669:Acupuncture Points; D000328:Adult; D004569:Electroencephalography; D005260:Female; D006801:Humans; D008297:Male; D008550:Melatonin / Q000097:blood*; D008991:Monitoring, Physiologic / Q000379:methods* / Q000523:psychology; D013315:Stress, Psychological / Q000097:blood* / Q000503:physiopathology; D001615:beta-Endorphin / Q000097:blood*
chemical_list: D001615:beta-Endorphin; D008550:Melatonin