title: Oat bran rapidly increases bile acid excretion and bile acid synthesis: an ileostomy study.
abstract: OBJECTIVE
  To study whether oat bran with native beta-glucans increases bile acid excretion and bile acid synthesis as measured by serum concentrations of 7alpha-hydroxy-4-cholesten-3-one (7alpha-HC).
  
  
  METHODS
  Short-term interventional crossover study evaluating cholesterol absorption, ileal excretion of cholesterol and bile acids, and serum levels of cholesterol and bile acid metabolites. Differences between diets evaluated with Wilcoxon's signed rank-sum test.
  
  
  METHODS
  Outpatients at a metabolic-ward kitchen.
  
  
  METHODS
  Nine volunteers with conventional ileostomies.
  
  
  METHODS
  Two 3-day-diet periods, with controlled, blinded basal diet including 75 g extruded oat bran breakfast cereal daily, with either 11.6 g native or hydrolysed beta-glucans.
  
  
  RESULTS
  Native oat bran increased median excretion of bile acids by 144% (P=0.008). Cholesterol excretion remained unchanged, cholesterol absorption decreased by 19% (P=0.013), whereas the sum of bile acid and cholesterol excretion increased by 40% (P=0.008) compared with hydrolysed oat bran. 7alpha-HC reflecting bile acid synthesis increased by 57% (P=0.008) within 24 h of consumption, whereas serum lathosterol concentration reflecting cholesterol synthesis increased by 12% (P=0.015).
  
  
  CONCLUSIONS
  Oat bran with native beta-glucans increases bile acid excretion within 24 h of consumption and this increase can also be detected by rising serum concentrations of 7alpha-HC. Thus, 7alpha-HC could be used for rapid detection of dietary effects on bile acid metabolism. These effects could possibly be explained by entrapment of whole micelles in the gut owing to higher viscosity.
authors.affiliation: Department of Clinical Nutrition, The Sahlgrenska Academy at the University of Göteborg, Sahlgrenska University Hospital, SE-405 30 Göteborg, Sweden. Lasse.Ellegard@nutrition.gu.se
authors.forename: L
authors.initials: L
authors.lastname: Ellegård
authors.forename: H
authors.initials: H
authors.lastname: Andersson
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018554:Avena / Q000737:chemistry*; D001647:Bile Acids and Salts / Q000096:biosynthesis* / Q000378:metabolism; D015415:Biomarkers / Q000097:blood; D002783:Cholestenones / Q000097:blood; D002784:Cholesterol / Q000378:metabolism; D018592:Cross-Over Studies; D004043:Dietary Fiber / Q000378:metabolism / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007081:Ileostomy; D007408:Intestinal Absorption; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D047071:beta-Glucans / Q000378:metabolism / Q000494:pharmacology*
chemical_list: D001647:Bile Acids and Salts; D015415:Biomarkers; D002783:Cholestenones; D004043:Dietary Fiber; D047071:beta-Glucans; C002656:7 alpha-hydroxy-4-cholesten-3-one; D002784:Cholesterol