title: Frequency-Dependent Selection for Plasmid-Containing Cells of ESCHERICHIA COLI.
abstract: Colicin-producing plasmid-containing cells of E. coli exhibit frequency-dependent selection when grown in glucose-limited continuous culture with the corresponding plasmid-free strain. The bases of this frequency-dependent effect are shown to be (1) the lower growth rate of the plasmid-containing strain under these conditions, and (2) the production of colicin, which attenuates the growth rate of the plasmid-free strain. These results are discussed in relationship to the maintenance of genetic variation in prokaryotes.
authors.forename: J
authors.initials: J
authors.lastname: Adams
authors.forename: T
authors.initials: T
authors.lastname: Kinney
authors.forename: S
authors.initials: S
authors.lastname: Thompson
authors.forename: L
authors.initials: L
authors.lastname: Rubin
authors.forename: R B
authors.initials: RB
authors.lastname: Helling