Increased risk of pregnancy-induced hypertension in young recipients of donated oocytes.
OBJECTIVE
To assess the rates of select obstetric outcomes in oocyte donation (OD) recipients aged <35 years and > or =40 years and compare them to similarly aged IVF patients.


METHODS
Retrospective anonymous questionnaire study.


METHODS
University-based IVF center.


METHODS
Live-birth outcome was experienced by 199 OD recipients and 488 IVF patients <35 or > or =40 years.


METHODS
The OD or IVF cycles.


METHODS
Response rate, pregnancy outcome, and complications.


RESULTS
Response rate was 60%. The OD recipients had significantly higher rates of pregnancy-induced hypertension (PIH) than their IVF counterparts. The OD <35 years had the highest rate (42%), followed by OD > or =40 years (26%), IVF > or =40 years (14%), and IVF patients <35 years (12%). In twin pregnancies, the rates of PIH remained higher in the OD groups: OD <35 years (56%), OD > or =40 years (36%), IVF > or =40 years (25%), and IVF <35 years (22%). Twin pregnancy rate was lowest in IVF patients > or =40 years (19%) and a lower preterm delivery rate (16%) reflected this difference. The cesarean section rates were 50% for singleton and 78% for twin deliveries in the OD patients <35 year; in OD patients > or =40 years, the rates were 75% and 84%, respectively.


CONCLUSIONS
The OD recipients are at higher risk for untoward obstetric outcomes than their IVF counterparts. Young OD recipients reported the highest rate of PIH, warranting further investigation into an association between early loss of ovarian function and PIH.
Keegan
Debbra A
DA
Division of Reproductive Endocrinology and Infertility, NYU School of Medicine, New York, New York, USA. kluged02@med.nyu.edu <kluged02@med.nyu.edu>
Krey
Lewis C
LC
Chang
Hung-Chi
HC
Noyes
Nicole
N
D000328:Adult; D002585:Cesarean Section / Q000706:statistics & numerical data; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000453:epidemiology / Q000209:etiology*; D008423:Maternal Age; D007752:Obstetric Labor, Premature / Q000453:epidemiology; D018587:Oocyte Donation; D011247:Pregnancy; D012189:Retrospective Studies; D012307:Risk Factors; D014427:Twins