Preservative effect of electrolyzed reduced water on pancreatic beta-cell mass in diabetic db/db mice.
Oxidative stress is produced under diabetic conditions and involved in progression of pancreatic beta-cell dysfunction. Both an increase in reactive oxygen free radical species (ROS) and a decrease in the antioxidant defense mechanism lead to the increase in oxidative stress in diabetes. Electrolyzed reduced water (ERW) with ROS scavenging ability may have a potential effect on diabetic animals, a model for high oxidative stress. Therefore, the present study examined the possible anti-diabetic effect of ERW in genetically diabetic mouse strain C57BL/6J-db/db (db/db). ERW with ROS scavenging ability reduced the blood glucose concentration, increased blood insulin level, improved glucose tolerance and preserved beta-cell mass in db/db mice. The present data suggest that ERW may protects beta-cell damage and would be useful for antidiabetic agent.
Kim
Mi-Ja
MJ
Department of Obesity Management, Graduate School of Obesity Science, Dongduk Women's University, Seoul, South Korea. mijakim@dongduck.ac.jp
Jung
Kyung Hee
KH
Uhm
Yoon Kyung
YK
Leem
Kang-Hyun
KH
Kim
Hye Kyung
HK
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D004195:Disease Models, Animal; D004572:Electrolysis; D005951:Glucose Tolerance Test; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D007328:Insulin / Q000097:blood; D050417:Insulin-Secreting Cells / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008297:Male; D051379:Mice; D008820:Mice, Obese; D010084:Oxidation-Reduction; D014867:Water
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin; D014867:Water