Biomechanics of abdominal aortic aneurysm.
Abdominal aortic aneurysm (AAA) is a condition whereby the terminal aorta permanently dilates to dangerous proportions, risking rupture. The biomechanics of AAA has been studied with great interest since aneurysm rupture is a mechanical failure of the degenerated aortic wall and is a significant cause of death in developed countries. In this review article, the importance of considering the biomechanics of AAA is discussed, and then the history and the state-of-the-art of this field is reviewed--including investigations into the biomechanical behavior of AAA tissues, modeling AAA wall stress and factors which influence it, and the potential clinical utility of these estimates in predicting AAA rupture.
Vorp
David A
DA
Department of Surgery, Division of Vascular Surgery, Department of Bioengineering, McGowan Institute for Regenerative Medicine, Center for Vascular Remodeling and Regeneration, University of Pittsburgh, Pittsburgh, PA, USA. VorpDA@upmc.edu
D000818:Animals; D017544:Aortic Aneurysm, Abdominal / Q000175:diagnosis / Q000503:physiopathology*; D001696:Biomechanical Phenomena; D006801:Humans; D015233:Models, Statistical