title: Bioactive saponins and glycosides. XXVIII. New triterpene saponins, foliatheasaponins I, II, III, IV, and V, from Tencha (the leaves of Camellia sinensis).
abstract: New triterpene saponins, foliatheasaponins I-V, were isolated from the methanolic extract of Tencha [the leaves of Camellia sinensis (L.) O. KUNTZE (Theaceae)]. The chemical structures of these new saponins were elucidated on the basis of chemical and physicochemical evidence. Among the new saponins, foliatheasaponins II and III, were found to inhibit release of beta-hexosaminidase, as a marker of antigen-induced degranulation, in RBL-2H3 cells.
authors.affiliation: Kyoto Pharmaceutical University, Misasagi, Kyoto, Japan.
authors.forename: Toshio
authors.initials: T
authors.lastname: Morikawa
authors.forename: Seikou
authors.initials: S
authors.lastname: Nakamura
authors.forename: Yasuyo
authors.initials: Y
authors.lastname: Kato
authors.forename: Osamu
authors.initials: O
authors.lastname: Muraoka
authors.forename: Hisashi
authors.initials: H
authors.lastname: Matsuda
authors.forename: Masayuki
authors.initials: M
authors.lastname: Yoshikawa
mesh_terms: D000818:Animals; D028241:Camellia sinensis / Q000737:chemistry*; D045744:Cell Line, Tumor / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D000432:Methanol / Q000737:chemistry; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry; D018515:Plant Leaves / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001619:beta-N-Acetylhexosaminidases / Q000037:antagonists & inhibitors / Q000378:metabolism
chemical_list: D010936:Plant Extracts; D012503:Saponins; D014315:Triterpenes; D001619:beta-N-Acetylhexosaminidases; D000432:Methanol