Effect of antibiotics on Staphylococcus aureus producing Panton-Valentine leukocidin.
We examined the capacity of Staphylococcus aureus strains to release Panton-Valentine leukocidin (PVL) in the presence of antibiotics. No PVL was detected when S. aureus was incubated at inhibitory concentrations, while subinhibitory concentrations of oxacillin enhanced the PVL level; clindamycin, linezolid, and fusidic acid were inhibitory; and vancomycin had roughly no effect.
Dumitrescu
Oana
O
INSERM, U851, Lyon, France.
Boisset
Sandrine
S
Badiou
Cedric
C
Bes
Michele
M
Benito
Yvonne
Y
Reverdy
Marie-Elisabeth
ME
Vandenesch
François
F
Etienne
Jerome
J
Lina
Gerard
G
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001427:Bacterial Toxins / Q000096:biosynthesis / Q000378:metabolism*; D005098:Exotoxins / Q000096:biosynthesis*; D007956:Leukocidins / Q000096:biosynthesis*; D008826:Microbial Sensitivity Tests; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism
D000900:Anti-Bacterial Agents; D001427:Bacterial Toxins; D005098:Exotoxins; D007956:Leukocidins; C078284:Panton-Valentine leukocidin