P-glycoprotein inhibitory activity of two phenolic compounds, (-)-syringaresinol and tricin from Sasa borealis.
(-)-Syringaresinol and tricin, isolated from the AcOEt-soluble extract of the whole plants of Sasa borealis (Gramineae), showed inhibitory effects on the P-glycoprotein in adriamycin-resistant human breast cancer cells, MCF-7/ADR.
Jeong
Yeon Hee
YH
College of Pharmacy, Ewha Womans University, Seoul 120-750, Korea.
Chung
Soo Yeon
SY
Han
Ah-Reum
AR
Sung
Min Kyung
MK
Jang
Dae Sik
DS
Lee
Jun
J
Kwon
Youngjoo
Y
Lee
Hwa Jeong
HJ
Seo
Eun-Kyoung
EK
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000037:antagonists & inhibitors*; D031723:Bambusa / Q000737:chemistry*; D045744:Cell Line, Tumor; D002855:Chromatography, Thin Layer; D005419:Flavonoids / Q000302:isolation & purification / Q000494:pharmacology*; D005663:Furans / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D017705:Lignans / Q000302:isolation & purification / Q000494:pharmacology*; D013057:Spectrum Analysis
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D005419:Flavonoids; D005663:Furans; D017705:Lignans; C042192:syringaresinol; C017769:tricin