title: Clobetasol ameliorates aphthous ulceration in renal transplant patients on sirolimus.
abstract: Aphthous ulceration is a common side effect of sirolimus. These lesions of the oral mucous membranes are often painful and debilitating, leading to either dose reduction or discontinuation of sirolimus in a significant number of patients. We report that the direct application of clobetasol, a high potency topical steroid, led to prompt resolution of the aphthous ulcers that developed in our renal transplant patients on sirolimus-based immunosuppression.
authors.affiliation: Department of Medicine, Division of Nephrology and Hypertension, Vanderbilt University Medical Center, S-3223 Medical Center North, Nashville, TN 37232, USA. pealechuang@hotmail.com
authors.forename: P
authors.initials: P
authors.lastname: Chuang
authors.forename: A J
authors.initials: AJ
authors.lastname: Langone
mesh_terms: D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D002990:Clobetasol / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D020123:Sirolimus / Q000009:adverse effects*; D013281:Stomatitis, Aphthous / Q000139:chemically induced / Q000188:drug therapy*
chemical_list: D000893:Anti-Inflammatory Agents; D007166:Immunosuppressive Agents; D002990:Clobetasol; D020123:Sirolimus