title: Sentinel lymph node biopsy is feasible even after total mastectomy.
abstract: BACKGROUND
  Previous mastectomy is unanimously considered to represent an absolute technical contraindication to sentinel lymph node biopsy (SLNB).
  
  
  METHODS
  Four patients who underwent total mastectomy and plastic reconstruction with prosthesis, developed, during the follow up, a unique invasive limited local subdermic recurrence amenable to surgical excision, with clinically negative axillary nodes. In all patients preoperative lymphoscintigraphy with subdermal injection of (99m)Tc-labeled colloidal particles correctly showed an axillary sentinel lymph node (SLN).
  
  
  RESULTS
  Metastases in SLN were detected in two patients, and a complete axillary dissection followed. The remaining two patients had a negative SLN and no axillary clearance was performed.
  
  
  CONCLUSIONS
  In selected cases, the subdermal injection of radioisotope permits the identification of an axillary SLN, even in mastectomized patients. Despite SLNB in mastectomized patients being technically feasible, only a larger population and longer patient follow up could confirm its true predictive value. However, there are no anatomical or physiological reasons to exclude "a priori" this diagnostic opportunity.
authors.affiliation: Division of Breast Surgery, European Institute of Oncology, Milan, Italy. mattia.intra@ieo.it
authors.forename: Mattia
authors.initials: M
authors.lastname: Intra
authors.forename: Paolo
authors.initials: P
authors.lastname: Veronesi
authors.forename: Oreste D
authors.initials: OD
authors.lastname: Gentilini
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Trifirò
authors.forename: Anastasio
authors.initials: A
authors.lastname: Berrettini
authors.forename: Rafaela
authors.initials: R
authors.lastname: Cecilio
authors.forename: Marco
authors.initials: M
authors.lastname: Colleoni
authors.forename: Mario
authors.initials: M
authors.lastname: Rietjens
authors.forename: Alberto
authors.initials: A
authors.lastname: Luini
authors.forename: Giovanni
authors.initials: G
authors.lastname: Paganelli
authors.forename: Umberto
authors.initials: U
authors.lastname: Veronesi
mesh_terms: D001365:Axilla; D001943:Breast Neoplasms / Q000473:pathology* / Q000601:surgery*; D018270:Carcinoma, Ductal, Breast / Q000473:pathology* / Q000601:surgery*; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008197:Lymph Node Excision; D008198:Lymph Nodes / Q000000981:diagnostic imaging / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D016462:Mammaplasty; D015413:Mastectomy, Simple; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis; D011237:Predictive Value of Tests; D011877:Radionuclide Imaging; D021701:Sentinel Lymph Node Biopsy; D016217:Ultrasonography, Mammary