title: Air pollution and development of asthma, allergy and infections in a birth cohort.
abstract: Few studies have addressed associations between traffic-related air pollution and respiratory disease in young children. The present authors assessed the development of asthmatic/allergic symptoms and respiratory infections during the first 4 yrs of life in a birth cohort study (n = approximately 4,000). Outdoor concentrations of traffic-related air pollutants (nitrogen dioxide PM(2.5), particles with a 50% cut-off aerodynamic diameter of 2.5 mum and soot) were assigned to birthplace home addresses with a land-use regression model. They were linked by logistic regression to questionnaire data on doctor-diagnosed asthma, bronchitis, influenza and eczema and to self-reported wheeze, dry night-time cough, ear/nose/throat infections and skin rash. Total and specific immunoglobulin (Ig)E to common allergens were measured in a subgroup (n = 713). Adjusted odds ratios (95% confidence intervals) per interquartile pollution range were elevated for wheeze (1.2 (1.0-1.4) for soot), doctor-diagnosed asthma (1.3 (1.0-1.7)), ear/nose/throat infections (1.2 (1.0-1.3)) and flu/serious colds (1.2 (1.0-1.4)). No consistent associations were observed for other end-points. Positive associations between air pollution and specific sensitisation to common food allergens (1.6 (1.2-2.2) for soot), but not total IgE, were found in the subgroup with IgE measurements. Traffic-related pollution was associated with respiratory infections and some measures of asthma and allergy during the first 4 yrs of life.
authors.affiliation: University of British Columbia, School of Occupational and Environmental Hygiene, 2206 East Mall, Vancouver BC V6T1Z3, Canada. brauer@interchange.ubc.ca
authors.forename: M
authors.initials: M
authors.lastname: Brauer
authors.forename: G
authors.initials: G
authors.lastname: Hoek
authors.forename: H A
authors.initials: HA
authors.lastname: Smit
authors.forename: J C
authors.initials: JC
authors.lastname: de Jongste
authors.forename: J
authors.initials: J
authors.lastname: Gerritsen
authors.forename: D S
authors.initials: DS
authors.lastname: Postma
authors.forename: M
authors.initials: M
authors.lastname: Kerkhof
authors.forename: B
authors.initials: B
authors.lastname: Brunekreef
mesh_terms: D000393:Air Pollutants / Q000633:toxicity*; D002675:Child, Preschool; D004781:Environmental Exposure / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis; D015994:Incidence; D007223:Infant; D016015:Logistic Models; D008297:Male; D009426:Netherlands / Q000453:epidemiology; D015995:Prevalence; D011446:Prospective Studies; D012044:Regression Analysis; D012140:Respiratory Tract Diseases / Q000139:chemically induced* / Q000453:epidemiology; D012307:Risk Factors; D011795:Surveys and Questionnaires; D001335:Vehicle Emissions / Q000633:toxicity*
chemical_list: D000393:Air Pollutants; D001335:Vehicle Emissions; D007073:Immunoglobulin E