Subcellular multitasking - multiple destinations and roles for the Plasmodium falcilysin protease.
The Plasmodium falcilysin protease is a M16-family protease that has been previously identified as a food vacuole enzyme that participates in the breakdown of haemoglobin. Plant homologues of this protease are responsible for breaking down transit peptides that have been processed in mitochondria and plastids, and in this issue of Molecular Microbiology, Ponpuak and colleagues show that falcilysin participates in degradation of transit peptides and haemoglobin in discrete subcellular organelles. The recruitment of a gene product from one cellular compartment to another is a recurring phenomenon in molecular evolutionary biology, and arises through a number of distinct mechanisms. Plasmodium accomplishes this triple act by targeting products of the single falcilysin gene to multiple compartments.
Ralph
Stuart A
SA
The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia. sralph@wehi.edu.au
D000818:Animals; D006454:Hemoglobins / Q000378:metabolism; D008666:Metalloendopeptidases / Q000378:metabolism*; D010455:Peptides / Q000378:metabolism; D010963:Plasmodium falciparum / Q000201:enzymology*; D020033:Protein Isoforms; D021381:Protein Transport; D015800:Protozoan Proteins / Q000378:metabolism*
D006454:Hemoglobins; D010455:Peptides; D020033:Protein Isoforms; D015800:Protozoan Proteins; D008666:Metalloendopeptidases; C400754:falcilysin protein, Plasmodium falciparum