[Effects of Alternanthera philoxeroides Griseb against respiratory syncytial virus infection in mice].
OBJECTIVE
To investigate the effect of an oral preparation of Alternathera philoxeroides Griseb (APG) against respiratory syncytical virus (RSV) in mice.


METHODS
APG preparation was administered orally in RSV-infected mice at different daily doses (2.5, 4.5 and 6.5 g/kg) to observe the therapeutic effect of the preparation.


RESULTS
Distinct differences were observed between the death rate of the mice treated with APG at daily dose of 4.5 and 6.5 g/kg and that of the untreated mice with infection. After AGP treatment of the mice at 6.5 g/kg, the detection rate of the virus was 31.3% in the blood and 37.5% in the lung tissue, significantly lower than that in the untreated mice. The virus detection rate was 43.8% in the lung tissues of mice treated with APG at 4.5 g/kg, also significantly lower than that in the untreated control. APG treatment at the 3 doses resulted in different lung indices from that of the control.


CONCLUSIONS
APG may be effective for treatment of RSV infection.
Jiang
Wen-Ling
WL
Medical Research Center of People's Hospital of Guangdong Province, Guangzhou 510080, China. jwenling@126.com
Yang
Zhan-Qiu
ZQ
Chen
Wen
W
Xiao
Hong
H
Luo
Xian-Ling
XL
D000284:Administration, Oral; D027703:Amaranthaceae / Q000737:chemistry*; D000818:Animals; D000998:Antiviral Agents / Q000008:administration & dosage / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D005260:Female; D008168:Lung / Q000187:drug effects / Q000473:pathology / Q000821:virology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008517:Phytotherapy; D028321:Plant Preparations / Q000008:administration & dosage / Q000627:therapeutic use*; D011897:Random Allocation; D018357:Respiratory Syncytial Virus Infections / Q000188:drug therapy*; D012136:Respiratory Syncytial Viruses / Q000187:drug effects*; D016896:Treatment Outcome
D000998:Antiviral Agents; D028321:Plant Preparations