Synthesis of symmetrical and unsymmetrical pyrazines.
Opening of representative epoxides with 1,2-amino alcohols delivered the amino diols. The product amino diols were then oxidized under Swern conditions. The amino diketones so prepared were not isolated, but were condensed directly with hydroxylamine to give the substituted pyrazines.
Taber
Douglass F
DF
Department of Chemistry and Biochemistry, University of Delaware, Newark, DE 19716, USA. taberdf@udel.edu
DeMatteo
Peter W
PW
Taluskie
Karen V
KV
D015394:Molecular Structure; D011719:Pyrazines / Q000138:chemical synthesis*
D011719:Pyrazines