Brain injury after intracerebral hemorrhage: the role of thrombin and iron.
Intracerebral hemorrhage (ICH) is a subtype of stroke with high morbidity and mortality. The mechanisms underlying ICH-induced brain injury have become better understood during the past decade. Experimental investigations have indicated that thrombin formation, red blood cell lysis, and iron toxicity play a major role in ICH-induced injury and that these mechanisms may provide new therapeutic targets. This article reviews the role of thrombin and iron in ICH-induced injury.
Hua
Ya
Y
Department of Neurosurgery, University of Michigan, Ann Arbor, MI 48109-2200, USA.
Keep
Richard F
RF
Hoff
Julian T
JT
Xi
Guohua
G
D000818:Animals; D001930:Brain Injuries / Q000209:etiology / Q000378:metabolism* / Q000473:pathology; D002543:Cerebral Hemorrhage / Q000150:complications / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007501:Iron / Q000502:physiology*; D013917:Thrombin / Q000502:physiology*
D007501:Iron; D013917:Thrombin