title: RK-95113, a new angiogenesis inhibitor produced by Aspergillus fumigatus.
abstract: We found that the strain Aspergillus fumigatus var. fumigatus RK95-113 produced a new angiogenesis inhibitor, RK-95113. Spectroscopic analyses identified the structure of RK-95113 as a new fumagillin-related small molecule. RK-95113 preferentially inhibited the growth of human umbilical vein endothelial cells (HUVECs) rather than that of human normal fibroblasts in cell proliferation assays and blocked endothlial cell migration induced by vascular endothelial growth factor (VEGF).
authors.affiliation: Antibiotics Laboratory, Discovery Research Institute, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Asami
authors.forename: Hideaki
authors.initials: H
authors.lastname: Kakeya
authors.forename: Gen
authors.initials: G
authors.lastname: Okada
authors.forename: Masakazu
authors.initials: M
authors.lastname: Toi
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Osada
mesh_terms: D020533:Angiogenesis Inhibitors / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D001232:Aspergillus fumigatus / Q000737:chemistry / Q000378:metabolism; D048708:Cell Growth Processes / Q000187:drug effects; D002465:Cell Movement / Q000187:drug effects; D042783:Endothelial Cells / Q000166:cytology / Q000187:drug effects; D004852:Epoxy Compounds / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D005285:Fermentation; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects; D006801:Humans; D019906:Nuclear Magnetic Resonance, Biomolecular; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D020533:Angiogenesis Inhibitors; D004852:Epoxy Compounds; C517258:RK-95113; D012717:Sesquiterpenes