[Protective effects of Evodia rutaecarpa water extract on ethanol-induced rat gastric lesions].
OBJECTIVE
To investigate the protective effects of Evodia rutaecarpa water extract on ethanol-induced acute gastric lesions in rats.


METHODS
In this study, animals were intraperitoneally pretreated with vehicle (normal saline) or E. rutaecarpa at 424.8, 141.6, 47.2 mg x kg(-1). Three hours later, gastric lesions were induced by topical application of 50% ethanol for 10 min. The rat gastric transmucosal potential difference (PD) was recorded continuously by ex-vivo chamber technique. NO(x) (nitrate and nitrite) level in gastric perfusate and the length index of gastric lesions were determined in a gastric intubatton model.


RESULTS
Compared with control, Evodia rutaecarpa water extract accelerated PD recovery and reduced gastric morphologic lesions in a dose-dependent manner (P < 0.05) , and also dose-dependently increased NO(x) level in gastric perfusate. Especially, at 424.8 mg x kg(-1), E. rutaecarpa promoted synthesizing of nitric oxide significantly (P < 0. 01).


CONCLUSIONS
E. rutaecarpa water extract showed effectively protective actions on ethanol-induced acute gastric lesions in rats, and the gastroprotective mechanisms maybe due to the strengthening action on gastric mucosal lining and the promotion of nitric oxide synthesis in local gastric mucosa.
Yu
Xiao
X
Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Wu
Da-Zheng
DZ
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D000431:Ethanol; D032086:Evodia / Q000737:chemistry; D005753:Gastric Mucosa / Q000378:metabolism / Q000473:pathology; D008297:Male; D009569:Nitric Oxide / Q000096:biosynthesis; D010946:Plants, Medicinal / Q000737:chemistry; D020011:Protective Agents / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013276:Stomach Ulcer / Q000139:chemically induced / Q000378:metabolism / Q000473:pathology*
D004365:Drugs, Chinese Herbal; D020011:Protective Agents; D009569:Nitric Oxide; D000431:Ethanol