title: Control of human immunodeficiency virus type 1 is associated with HLA-B*13 and targeting of multiple gag-specific CD8+ T-cell epitopes.
abstract: To better understand relationships between CD8+ T-cell specificity and the immune control of human immunodeficiency virus type 1 (HIV-1), we analyzed the role of HLA-B*13, an allele associated with low viremia, in a cohort of 578 C clade-infected individuals in Durban, South Africa. Six novel B*13-restricted cytotoxic T lymphocyte epitopes were defined from analyses of 37 B*13-positive subjects, including three Gag epitopes. These B*13-restricted epitopes contribute to a broad Gag-specific CD8+ response that is associated with the control of viremia. These data are consistent with data from studies of other HLA-class I alleles associated with HIV control that have shown that the targeting of multiple Gag epitopes is associated with relative suppression of viremia.
authors.affiliation: Department of Paediatrics, Peter Medawar Building for Pathogen Research, South Parks Road, Oxford OX1 3SY, United Kingdom.
authors.forename: Isobella
authors.initials: I
authors.lastname: Honeyborne
authors.forename: Andrew
authors.initials: A
authors.lastname: Prendergast
authors.forename: Florencia
authors.initials: F
authors.lastname: Pereyra
authors.forename: Alasdair
authors.initials: A
authors.lastname: Leslie
authors.forename: Hayley
authors.initials: H
authors.lastname: Crawford
authors.forename: Rebecca
authors.initials: R
authors.lastname: Payne
authors.forename: Shabashini
authors.initials: S
authors.lastname: Reddy
authors.forename: Karen
authors.initials: K
authors.lastname: Bishop
authors.forename: Eshia
authors.initials: E
authors.lastname: Moodley
authors.forename: Kriebashnie
authors.initials: K
authors.lastname: Nair
authors.forename: Mary
authors.initials: M
authors.lastname: van der Stok
authors.forename: Noel
authors.initials: N
authors.lastname: McCarthy
authors.forename: Christine M
authors.initials: CM
authors.lastname: Rousseau
authors.forename: Marylyn
authors.initials: M
authors.lastname: Addo
authors.forename: James I
authors.initials: JI
authors.lastname: Mullins
authors.forename: Christian
authors.initials: C
authors.lastname: Brander
authors.forename: Photini
authors.initials: P
authors.lastname: Kiepiela
authors.forename: Bruce D
authors.initials: BD
authors.lastname: Walker
authors.forename: Philip J R
authors.initials: PJ
authors.lastname: Goulder
mesh_terms: D000595:Amino Acid Sequence; D018414:CD8-Positive T-Lymphocytes / Q000737:chemistry / Q000276:immunology*; D018984:Epitopes, T-Lymphocyte / Q000276:immunology*; D015683:Gene Products, gag / Q000235:genetics / Q000276:immunology*; D015497:HIV-1 / Q000276:immunology*; D015235:HLA-B Antigens / Q000737:chemistry / Q000276:immunology*; D059908:HLA-B13 Antigen; D006801:Humans; D008969:Molecular Sequence Data; D009154:Mutation / Q000235:genetics
chemical_list: D018984:Epitopes, T-Lymphocyte; D015683:Gene Products, gag; D015235:HLA-B Antigens; D059908:HLA-B13 Antigen