title: Medicinal flowers. XII.(1)) New spirostane-type steroid saponins with antidiabetogenic activity from Borassus flabellifer.
abstract: The methanolic extract from the male flowers of Borassus flabellifer was found to inhibit the increase of serum glucose levels in sucrose-loaded rats at a dose of 250 mg/kg, p.o. From the methanolic extract, six new spirostane-type steroid saponins, borassosides A-F (1-6), were isolated together with 23 known constituents. The structures of borassosides (1-6) were elucidated on the basis of chemical and physicochemical evidences. In addition, the principal steroid saponin, dioscin (13), inhibited the increase of serum glucose levels in sucrose-loaded rats at a dose of 50 mg/kg, p.o.
authors.affiliation: Kyoto Pharmaceutical University, Misasagi, Kyoto, Japan. myoshika@mb.kyoto-phu.ac.jp
authors.forename: Masayuki
authors.initials: M
authors.lastname: Yoshikawa
authors.forename: Fengming
authors.initials: F
authors.lastname: Xu
authors.forename: Toshio
authors.initials: T
authors.lastname: Morikawa
authors.forename: Yutana
authors.initials: Y
authors.lastname: Pongpiriyadacha
authors.forename: Seikou
authors.initials: S
authors.lastname: Nakamura
authors.forename: Yasunobu
authors.initials: Y
authors.lastname: Asao
authors.forename: Akira
authors.initials: A
authors.lastname: Kumahara
authors.forename: Hisashi
authors.initials: H
authors.lastname: Matsuda
mesh_terms: D000818:Animals; D028023:Arecaceae / Q000737:chemistry*; D001786:Blood Glucose / Q000378:metabolism; D004144:Diosgenin / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D008297:Male; D000432:Methanol / Q000737:chemistry; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013997:Time Factors
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D010936:Plant Extracts; D012503:Saponins; C019357:dioscin; D004144:Diosgenin; D000432:Methanol