title: Neurotoxic prion protein (PrP) fragment 106-126 requires the N-terminal half of the hydrophobic region of PrP in the PrP-deficient neuronal cell line.
abstract: The cytotoxicity of aged PrP(106-126) was examined using an immortalized prion protein (PrP) gene-deficient neuronal cell line. The N-terminal half of the hydrophobic region (HR) but not the octapeptide repeat (OR) of PrP was required for aged PrP(106-126) neurotoxicity, suggesting that neurotoxic signals of aged PrP(106-126) are mediated by this region.
authors.affiliation: Department of Molecular Immunology, School of Agricultural and Life Sciences, University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan.
authors.forename: Akikazu
authors.initials: A
authors.lastname: Sakudo
authors.forename: Izuru
authors.initials: I
authors.lastname: Nakamura
authors.forename: Deug-Chan
authors.initials: DC
authors.lastname: Lee
authors.forename: Keiichi
authors.initials: K
authors.lastname: Saeki
authors.forename: Kazuyoshi
authors.initials: K
authors.lastname: Ikuta
authors.forename: Takashi
authors.initials: T
authors.lastname: Onodera
mesh_terms: D016923:Cell Death / Q000187:drug effects; D002460:Cell Line; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D009474:Neurons / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism*; D010446:Peptide Fragments / Q000737:chemistry* / Q000633:toxicity*; D011328:Prions / Q000737:chemistry* / Q000633:toxicity*; D013482:Superoxide Dismutase
chemical_list: D010446:Peptide Fragments; D011328:Prions; D013482:Superoxide Dismutase