title: In vitro activity of olive oil polyphenols against Helicobacter pylori.
abstract: Helicobacter pylori is linked to a majority of peptic ulcers and to some types of gastric cancer, and resistance of the microorganism to antibiotic treatment is now found worldwide. Virgin olive oil is an unrefined vegetable oil that contains a significant amount of phenolic compounds. Under simulated conditions, we have demonstrated that these substances can diffuse from the oil into the gastric juice and be stable for hours in this acidic environment. In vitro, they exerted a strong bactericidal activity against eight strains of H. pylori, three of them resistant to some antibiotics. Among the phenolic compounds, the dialdehydic form of decarboxymethyl ligstroside aglycon showed the strongest bactericidal effect at a concentration as low as 1.3 microg/mL. Although the experimental conditions are different from other reported works, this bactericidal concentration is much lower than those found for phenolic compounds from tea, wine, and plant extracts. These results open the possibility of considering virgin olive oil a chemopreventive agent for peptic ulcer or gastric cancer, but this bioactivity should be confirmed in vivo in the future.
authors.affiliation: Food Biotechnology Department, Instituto de la Grasa (CSIC), Avenida Padre García Tejero 4, 41012 Seville, Spain.
authors.forename: Concepción
authors.initials: C
authors.lastname: Romero
authors.forename: Eduardo
authors.initials: E
authors.lastname: Medina
authors.forename: Julio
authors.initials: J
authors.lastname: Vargas
authors.forename: Manuel
authors.initials: M
authors.lastname: Brenes
authors.forename: Antonio
authors.initials: A
authors.lastname: De Castro
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004355:Drug Stability; D005419:Flavonoids / Q000737:chemistry / Q000494:pharmacology*; D005750:Gastric Juice / Q000737:chemistry; D016480:Helicobacter pylori / Q000187:drug effects*; D006851:Hydrochloric Acid; D000069463:Olive Oil; D010636:Phenols / Q000737:chemistry / Q000494:pharmacology*; D010938:Plant Oils / Q000737:chemistry*; D059808:Polyphenols
chemical_list: D000900:Anti-Bacterial Agents; D005419:Flavonoids; D000069463:Olive Oil; D010636:Phenols; D010938:Plant Oils; D059808:Polyphenols; D006851:Hydrochloric Acid