title: Growth rate of locally recurrent hepatocellular carcinoma after transcatheter arterial chemoembolization: comparing the growth rate of locally recurrent tumor with that of primary hepatocellular carcinoma.
abstract: We compared the growth rate of locally recurrent hepatocellular carcinoma (HCC) with that of primary HCC. After the first treatment by transcatheter arterial chemoembolization (TACE), 60 locally recurrent HCC nodules were reviewed. The tumor volume doubling time (DT) of locally recurrent HCC was significantly shorter than that of primary HCC. The 95% lower threshold value was 17.7 days. The 6-, 12-, and 36-month recurrence-free rates of the tumors having DTs more than 70 days after the second TACE (77.7%, 53.8%, and 40.4%) were significantly higher than those of the tumors having DTs less than 70 days (26.7%, 26.7%, and 17.8%). Locally recurrent HCCs cannot double in diameter in less than 53 days. In the case that an equivocal lesion smaller than the section collimation depicted during a contrast-enhanced computed tomography (CECT) screening cannot be ruled out as local recurrence, the next CECT screening should be performed 2 months later.
authors.affiliation: Department of Radiology, Nakano General Hospital, 4-59-16 Chuo, Nakano-ku, Tokyo 164-0011, Japan. tdkmik@blue.ocn.ne.jp
authors.forename: Mikio
authors.initials: M
authors.lastname: Tezuka
authors.forename: Keiji
authors.initials: K
authors.lastname: Hayashi
authors.forename: Kazunori
authors.initials: K
authors.lastname: Kubota
authors.forename: Sachiko
authors.initials: S
authors.lastname: Sekine
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Okada
authors.forename: Hiroyasu
authors.initials: H
authors.lastname: Ina
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Irie
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001964:Bromhexine; D006528:Carcinoma, Hepatocellular / Q000000981:diagnostic imaging / Q000473:pathology* / Q000628:therapy; D016461:Chemoembolization, Therapeutic; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology*; D011856:Radiographic Image Enhancement
chemical_list: D001964:Bromhexine