title: Specific stabilization of DNA triple helices by indolo[2,1-b]quinazolin-6,12-dione derivatives.
abstract: Derivatives of indolo[2,1-b]quinazolinone containing aminoalkylamino side chains were synthesized as specific DNA triplex stabilizing agents. The aminoalkylamino side chains are essential for triplex stabilization. The position-8 fluorine atom or a methyl group to the nitrogen adjacent to the planar core can enhance triplex stability by 6 degrees C and the effect is additive. Conformational analysis reveals that the orientation of the side chain underlies the ability of this compound to stabilize a DNA triplex.
authors.affiliation: Department of Applied Chemistry, Providence University, Sha-Lu 43301, Taiwan, ROC.
authors.forename: Grace Shiahuy
authors.initials: GS
authors.lastname: Chen
authors.forename: Bhalchandra V
authors.initials: BV
authors.lastname: Bhagwat
authors.forename: Pei-Yin
authors.initials: PY
authors.lastname: Liao
authors.forename: Hui-Ting
authors.initials: HT
authors.lastname: Chen
authors.forename: Shwu-Bin
authors.initials: SB
authors.lastname: Lin
authors.forename: Ji-Wang
authors.initials: JW
authors.lastname: Chern
mesh_terms: D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002942:Circular Dichroism; D004247:DNA / Q000737:chemistry* / Q000187:drug effects*; D007211:Indoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D008024:Ligands; D009690:Nucleic Acid Conformation / Q000187:drug effects; D011799:Quinazolines / Q000138:chemical synthesis* / Q000494:pharmacology*; D013056:Spectrophotometry, Ultraviolet
chemical_list: D007211:Indoles; D008024:Ligands; D011799:Quinazolines; C046243:tryptanthrine; D004247:DNA