Permanent lithium-induced cerebellar toxicity: three cases and review of literature.
Lithium can have toxic effects on the central nervous system that are both acute and chronic. Uncommonly, a long-lasting cerebellar syndrome follows acute toxicity. The mechanism of cerebellar injury is not well understood. We present 3 cases of this syndrome, with video demonstrating the typical features of this syndrome.
Niethammer
Martin
M
Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York, USA. mniethammer@neuro.columbia.edu
Ford
Blair
B
D000328:Adult; D000928:Antidepressive Agents / Q000009:adverse effects*; D001284:Atrophy / Q000473:pathology / Q000503:physiopathology; D001714:Bipolar Disorder / Q000188:drug therapy*; D002524:Cerebellar Ataxia / Q000139:chemically induced* / Q000473:pathology* / Q000503:physiopathology; D002531:Cerebellum / Q000473:pathology / Q000503:physiopathology; D003865:Major Depressive Disorder / Q000188:drug therapy*; D005260:Female; D006801:Humans; D016651:Lithium Carbonate / Q000009:adverse effects* / Q000097:blood; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D014743:Videotape Recording
D000928:Antidepressive Agents; D016651:Lithium Carbonate