title: Factors affecting continence after fistulotomy for intersphincteric fistula-in-ano.
abstract: OBJECTIVE
  This study was undertaken to determine the incidence of and risk factors for anal incontinence after fistulotomy for intersphincteric fistula-in-ano. We also evaluated the role of anal manometry in preoperative assessment of intersphincteric fistula.
  
  
  METHODS
  A prospective, observational study was undertaken in 148 patients who underwent fistulotomy for intersphincteric fistula between January and December 2004. Functional results were assessed by standard questionnaire and anal manometry. Possible factors predicting postoperative incontinence were examined by univariate and multivariate regression analyses.
  
  
  RESULTS
  The mean follow-up period was 12 months. Postoperative anal incontinence occurred in 30 patients (20.3%), i.e., soiling in 6, incontinence for flatus in 27, and incontinence for liquid stool in 4. Fistulotomy significantly decreased maximum resting pressure (85.9 +/- 20.4 to 60.2 +/- 18.4 mmHg, P < 0.0001) and length of the high pressure zone (3.92 +/- 0.69 to 3.82 +/- 0.77 cm, P = 0.035), but it did not affect voluntary contraction pressure (164.7 +/- 85.2 to 160.3 +/- 84.8 mmHg, P = 0.2792). Multivariate analysis showed low voluntary contraction pressure and multiple previous drainage surgeries to be independent risk factors for postoperative incontinence.
  
  
  CONCLUSIONS
  Fistulotomy produces a satisfactory outcome in terms of eradicating sepsis and preserving function in the vast majority of patients with intersphincteric fistula with intact sphincters. However, sphincter-preserving treatment may be advocated for patients with low preoperative voluntary contraction pressure or those who have undergone multiple drainage surgeries. Preoperative anal manometry is useful in determining the proper surgical procedure.
authors.affiliation: Department of Surgery, Matsushima Hospital Colo-Proctology Center, 19-11 Tobehoncho, Yokohama, Japan. toyozo7@yahoo.co.jp
authors.forename: Takayuki
authors.initials: T
authors.lastname: Toyonaga
authors.forename: Makoto
authors.initials: M
authors.lastname: Matsushima
authors.forename: Takashi
authors.initials: T
authors.lastname: Kiriu
authors.forename: Nobuhito
authors.initials: N
authors.lastname: Sogawa
authors.forename: Hiroki
authors.initials: H
authors.lastname: Kanyama
authors.forename: Naomi
authors.initials: N
authors.lastname: Matsumura
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Shimojima
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Hatakeyama
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Tanaka
authors.forename: Kazunori
authors.initials: K
authors.lastname: Suzuki
authors.forename: Masao
authors.initials: M
authors.lastname: Tanaka
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001003:Anal Canal / Q000601:surgery*; D013505:Digestive System Surgical Procedures / Q000009:adverse effects* / Q000379:methods; D005242:Fecal Incontinence / Q000209:etiology; D005260:Female; D006801:Humans; D008297:Male; D008365:Manometry / Q000379:methods*; D008875:Middle Aged; D011183:Postoperative Complications; D011446:Prospective Studies; D012003:Rectal Fistula / Q000503:physiopathology / Q000601:surgery*; D012307:Risk Factors; D016896:Treatment Outcome