title: Lagaspholones A and B: two new jatropholane-type diterpenes from Euphorbia lagascae.
abstract: [structure: see text] Two new diterpenes, lagaspholones A (1) and B (2), have been isolated from the methanolic extract of Euphorbia lagascae, along with the known compounds (+)-dehydrovomifoliol, scopoletin, dehydrodiconiferyl diacetate, 3-indolcarbaldehyde, and 4-hydroxy-3,5-dimethoxybenzaldehyde. Their structures were elucidated by spectroscopic methods. Compounds 1 and 2 contain the rare jatropholane-type skeleton, characterized by a 5:6:7:3 fused ring system. A possible biosynthetic pathway for lagaspholones is proposed.
authors.affiliation: CECF, Faculty of Pharmacy, University of Lisbon, Avenida das Forças Armadas, 1600-083 Lisbon, Portugal.
authors.forename: Noélia
authors.initials: N
authors.lastname: Duarte
authors.forename: Maria-José U
authors.initials: MJ
authors.lastname: Ferreira
mesh_terms: D000085:Acetates / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000447:Aldehydes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D001547:Benzaldehydes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D028481:Euphorbia / Q000737:chemistry*; D015394:Molecular Structure; D045792:Norisoprenoids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D010936:Plant Extracts / Q000737:chemistry*; D010946:Plants, Medicinal; D012603:Scopoletin / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: C506569:4-hydroxy-3,5-dimethoxybenzaldehyde; D000085:Acetates; D000447:Aldehydes; D000972:Antineoplastic Agents, Phytogenic; D001547:Benzaldehydes; D004224:Diterpenes; D045792:Norisoprenoids; D010936:Plant Extracts; C518572:lagaspholone A; C518573:lagaspholone B; C006386:jatrophone; D012603:Scopoletin