Options to preserve fertility before oncological treatment: cryopreservation of ovarian tissue and its clinical application.
Chemotherapy and radiotherapy induce premature ovarian failure in many patients treated with these methods for oncological and benign diseases. This paper reviews the risk of developing premature ovarian failure according to the types of treatment as well as the different options to preserve fertility. We focus mainly on the cryopreservation of ovarian tissue procedure and we report here the second world-wide spontaneous pregnancy after cryopreserved ovarian tissue transplantation.
Demeestere
I
I
Clinique de Fertilité, Laboratoire de Recherche en Reproduction Humaine, Département de gynécologie-obstétrique, Hôpital Erasme, Bruxelles, Belgique. idemeest@ulb.ac.be
Simon
P
P
Emiliani
S
S
Delbaere
A
A
Englert
Y
Y
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D015925:Cryopreservation; D004622:Embryo, Mammalian; D005260:Female; D005298:Fertility / Q000187:drug effects / Q000528:radiation effects; D006689:Hodgkin Disease / Q000188:drug therapy*; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy*; D009865:Oocytes; D010053:Ovary / Q000187:drug effects / Q000528:radiation effects; D016649:Primary Ovarian Insufficiency / Q000209:etiology*