Effect of chronic hyperglycemia on intraocular pressure in patients with diabetes.
OBJECTIVE
To investigate the effect of chronic hyperglycemia on intraocular pressure (IOP) in patients with diabetes.


METHODS
Cross-sectional study.


METHODS
We prospectively measured the IOP by Goldmann applanation tonometry in patients with diabetes with mild hyperglycemia (glycosylated hemoglobin A1c (HbA1c) < or = 6.5%), moderate hyperglycemia (6.5% < HbA1c < 8.0), and severe hyperglycemia (HbA1c > or = 8.0%). None of the patients with diabetes had diabetic retinopathy, secondary glaucoma, ocular or laser therapy, or history of glaucoma. The HbA1c level determined within three months of the IOP measurement was used. Statistical analysis was performed by Mann-Whitney U test. P < .05 was considered significant.


RESULTS
The mean IOP in the mild group (n = 58) was 15.5 +/- 2.5 mm Hg, which was statistically significantly lower than that of the severe group (16.6 +/- 2.4 mm Hg; P = .013; n = 60).


CONCLUSIONS
Chronic hyperglycemia is associated with increased IOP in patients with diabetes.
Oshitari
Toshiyuki
T
Department of Ophthalmology, Center for Sensory Organ Diseases, Sannoh Medical Center, Chiba, Japan. toshitari@hotmail.com
Fujimoto
Naoya
N
Hanawa
Katsuhiro
K
Adachi-Usami
Emiko
E
Roy
Sayon
S
D002908:Chronic Disease; D003430:Cross-Sectional Studies; D003920:Diabetes Mellitus / Q000503:physiopathology*; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D006943:Hyperglycemia / Q000503:physiopathology*; D007429:Intraocular Pressure / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D014065:Tonometry, Ocular
D006442:Glycated Hemoglobin