title: Simple and efficient heterogeneous copper catalysts for enantioselective C-H carbene insertion.
abstract: Immobilized box-Cu complexes are able to efficiently catalyze the insertion of a carbene, from methyl phenyldiazoacetate, into C-H bonds of THF, with high enantioselectivity (up to 88% ee). The immobilization not only allows recovery and reuse of the enantioselective catalyst but also provides an improvement in the selectivities from the values obtained in solution, probably due to a confinement effect of the bidimensional support. [reaction: see text].
authors.affiliation: Departamento de Química OrgAnica, Instituto de Ciencia de Materiales de Aragón and Instituto Universitario de CatAlisis Homogénea, Universidad de Zaragoza-C.S.I.C., E-50009 Zaragoza, Spain. jmfraile@unizar.es
authors.forename: José M
authors.initials: JM
authors.lastname: Fraile
authors.forename: José I
authors.initials: JI
authors.lastname: García
authors.forename: José A
authors.initials: JA
authors.lastname: Mayoral
authors.forename: Marta
authors.initials: M
authors.lastname: Roldán