Amelioration of aluminium-induced liver damage by vitamin E.
OBJECTIVE
To investigate the effects of aluminium sulphate on the microscopic morphology of the liver and on vitamin E amelioration of aluminium-induced liver damage.


METHODS
Rats were injected intraperitoneally with aluminium sulphate alone or aluminium sulphate together with vitamin E, with saline injected rats used as the control group. The study took place in Pamukkale University Faculty of Medicine in 2005.


RESULTS
The rats exposed to aluminium showed morphological changes in addition to previously reported biochemical changes in the liver. The anti-oxidant vitamin E significantly diminished the liver damage seen due to aluminium.


CONCLUSIONS
There is an apparent protective effect of vitamin E on parenteral aluminium exposure.
Kutlubay
Recep
R
Department of Histology and Embryology, Kinikli, Denizli, Turkey.
Oguz
Emin O
EO
Abban
Gulcin
G
Turgut
Sebahat
S
D000534:Alum Compounds / Q000494:pharmacology / Q000633:toxicity*; D000818:Animals; D001707:Biopsy, Needle; D056486:Chemical and Drug Induced Liver Injury; D019587:Dietary Supplements; D004195:Disease Models, Animal; D004347:Drug Interactions; D007150:Immunohistochemistry; D007274:Injections, Intraperitoneal; D008099:Liver / Q000187:drug effects / Q000473:pathology*; D008107:Liver Diseases / Q000473:pathology / Q000517:prevention & control*; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D012016:Reference Values; D012680:Sensitivity and Specificity; D014810:Vitamin E / Q000494:pharmacology*
D000534:Alum Compounds; D014810:Vitamin E; C041524:aluminum sulfate