title: E/Z-rubrolide O, an anti-inflammatory halogenated furanone from the New Zealand ascidian Synoicum n. sp.
abstract: Bioassay-directed fractionation of extracts of a Synoicum n. sp. ascidian from New Zealand led to the isolation of the principal anti-inflammatory component, which was identified by spectroscopic methods as a new member of the rubrolide family, rubrolide O (1), existing as a mixture of E/Z isomers.
authors.affiliation: TerraMarine Pharmaceuticals, Department of Chemistry, The University of Auckland, Private Bag 92019, Auckland, New Zealand.
authors.forename: A Norrie
authors.initials: AN
authors.lastname: Pearce
authors.forename: Elizabeth W
authors.initials: EW
authors.lastname: Chia
authors.forename: Michael V
authors.initials: MV
authors.lastname: Berridge
authors.forename: Elizabeth W
authors.initials: EW
authors.lastname: Maas
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Page
authors.forename: Victoria L
authors.initials: VL
authors.lastname: Webb
authors.forename: Jacquie L
authors.initials: JL
authors.lastname: Harper
authors.forename: Brent R
authors.initials: BR
authors.lastname: Copp
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D006846:Hydrocarbons, Halogenated / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D015394:Molecular Structure; D009504:Neutrophils / Q000378:metabolism; D009520:New Zealand; D013237:Stereoisomerism; D014561:Urochordata / Q000737:chemistry*
chemical_list: D000893:Anti-Inflammatory Agents; D005663:Furans; D006846:Hydrocarbons, Halogenated; C517714:rubrolide O