title: Controlling the association of adamantyl-substituted poly{N-[tris(hydroxymethyl)methyl]acrylamide} and a beta-cyclodextrin/epichlorohydrin polymer by a small drug molecule--naproxen.
abstract: Two polymeric substances, a poly{N-[tris(hydroxymethyl)methyl]acrylamide} (THMMA) substituted with adamantyl moieties and a beta-cyclodextrin/epichlorohydrin polycondensate, formed a host-guest type complex, which resulted in the gel formation upon mixing of these two compounds at appropriate conditions. Introduction of a drug molecule, i.e., naproxen, that was able to fill the beta-cyclodextrin cavities, thus expulsing adamantyl moieties, led to disruption of such association and inhibition of gel formation. The conditions required for the association of the two polymeric components and formation of the gel, as well as the dynamics of its inhibition by addition of naproxen was established. The procedure of using solutions of two associating polymers and an appropriate drug competitor can be used at targeted viscosupplementation.
authors.affiliation: Institute of Chemistry, Slovak Academy of Sciences, SK-84538 Bratislava, Slovak Republic.
authors.forename: Danica
authors.initials: D
authors.lastname: Mislovicová
authors.forename: Grigorij
authors.initials: G
authors.lastname: Kogan
authors.forename: Noëlle Martine
authors.initials: NM
authors.lastname: Gosselet
authors.forename: Bernard
authors.initials: B
authors.lastname: Sébille
authors.forename: Ladislav
authors.initials: L
authors.lastname: Soltés
mesh_terms: D000178:Acrylamides / Q000737:chemistry*; D004811:Epichlorohydrin / Q000737:chemistry*; D008958:Models, Molecular; D009288:Naproxen / Q000737:chemistry*; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D000178:Acrylamides; D047392:beta-Cyclodextrins; D004811:Epichlorohydrin; D009288:Naproxen; C031215:betadex