[Hypersensitivity reactions to antiretroviral agents in HIV-infected patients].
Drug hypersensitivity reactions in the HIV-positive patient are a major problem in management of these patients and, nowadays the antiretroviral agents are the main cause of those reactions, exceeding cotrimoxazole. The present review focuses on immunologic reactions that have been reported associated with antiretroviral agents. We have reviewed case reports on Medline(R) to September 2005. Evidence that these reactions are immune mediated is largely based on the typical symptomatology and few studies have been done to determine the pathogenesis mechanisms. The clinical management of this type of reactions is complex because of differential diagnosis and of potential severity. It is essential that research is now carried out into the pathogenic mechanisms and so, we shall be able to offer an efficacious protocol to manage these situations.
Marcos Bravo
M Carmen
MC
Sección de Alergología, Complexo Hospitalario Universitario Xeral-Cíes, Vigo, Pontevedra, España. carmen.marcos.bravo@sergas.es
Ocampo Hermida
Antonio
A
Moreno Rodilla
Ester
E
D017088:AIDS-Related Opportunistic Infections / Q000175:diagnosis; D019380:Anti-HIV Agents / Q000009:adverse effects* / Q000276:immunology / Q000627:therapeutic use; D003937:Diagnosis, Differential; D019468:Disease Management; D003875:Drug Eruptions / Q000175:diagnosis / Q000209:etiology; D004342:Drug Hypersensitivity / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D023581:HIV Fusion Inhibitors / Q000009:adverse effects / Q000276:immunology / Q000627:therapeutic use; D015658:HIV Infections / Q000188:drug therapy* / Q000276:immunology; D017320:HIV Protease Inhibitors / Q000009:adverse effects / Q000276:immunology / Q000627:therapeutic use; D006801:Humans; D018894:Reverse Transcriptase Inhibitors / Q000009:adverse effects / Q000145:classification / Q000276:immunology / Q000627:therapeutic use
D019380:Anti-HIV Agents; D023581:HIV Fusion Inhibitors; D017320:HIV Protease Inhibitors; D018894:Reverse Transcriptase Inhibitors