title: Tics moderate treatment outcome with sertraline but not cognitive-behavior therapy in pediatric obsessive-compulsive disorder.
abstract: BACKGROUND
  The presence of a comorbid tic disorder may predict a poorer outcome in the acute treatment of pediatric obsessive-compulsive disorder (OCD).
  
  
  METHODS
  Using data from the National Institute of Mental Health (NIMH)-funded Pediatric OCD Treatment Study (POTS) that compared cognitive-behavior therapy (CBT), medical management with sertraline (SER), and the combination of CBT and SER (COMB), to pill placebo (PBO) in children and adolescents with OCD, we asked whether the presence of a comorbid tic disorder influenced symptom reduction on the Children's Yale-Brown Obsessive Compulsive Scale (CY-BOCS) after 12 weeks of treatment.
  
  
  RESULTS
  Fifteen percent (17 of 112) of patients exhibited a comorbid tic disorder. In patients without tics, results replicated previously published intent-to-treat outcomes: COMB > CBT > SER > PBO. In patients with a comorbid tic disorder, SER did not differ from PBO, while COMB remained superior to CBT and CBT remained superior to PBO.
  
  
  CONCLUSIONS
  In contrast to CBT outcomes, which are not differentially impacted, tic disorders appear to adversely impact the outcome of medication management of pediatric OCD. Children and adolescents with obsessive-compulsive disorder and a comorbid tic disorder should begin treatment with cognitive-behavior therapy alone or the combination of cognitive-behavior therapy plus a serotonin reuptake inhibitor.
authors.affiliation: Department of Psychiatry, Duke University Medical Center, Durham, North Carolina 27710, USA. jsmarch@duke.edu
authors.forename: John S
authors.initials: JS
authors.lastname: March
authors.forename: Martin E
authors.initials: ME
authors.lastname: Franklin
authors.forename: Henrietta
authors.initials: H
authors.lastname: Leonard
authors.forename: Abbe
authors.initials: A
authors.lastname: Garcia
authors.forename: Phoebe
authors.initials: P
authors.lastname: Moore
authors.forename: Jennifer
authors.initials: J
authors.lastname: Freeman
authors.forename: Edna
authors.initials: E
authors.lastname: Foa
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D002648:Child; D015928:Cognitive Behavioral Therapy; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008297:Male; D009771:Obsessive-Compulsive Disorder / Q000188:drug therapy* / Q000523:psychology; D011569:Psychiatric Status Rating Scales; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use*; D020280:Sertraline / Q000627:therapeutic use*; D013981:Tic Disorders / Q000188:drug therapy* / Q000523:psychology / Q000628:therapy*; D005879:Tourette Syndrome / Q000188:drug therapy / Q000523:psychology
chemical_list: D017367:Selective Serotonin Reuptake Inhibitors; D020280:Sertraline