title: Altered esophageal sensory-motor function in patients with persistent symptoms after Nissen fundoplication.
abstract: BACKGROUND
  The pathophysiology of persistent gastroesophageal reflux disease (GERD) symptoms after antireflux surgery is unclear. We assessed esophageal sensorimotor function in patients with GERD before and after Nissen fundoplication (NF).
  
  
  METHODS
  Sensory and biomechanical properties were evaluated before surgery using impedance planimetry in 17 GERD patients and 16 healthy volunteers. All patients underwent standard laparoscopic NF. Eight GERD patients with persistent symptoms after surgery underwent repeat evaluations at least 12 months after surgery.
  
  
  RESULTS
  At baseline, GERD patients had lower thresholds for first perception (P < .001), discomfort (P < .001), and pain (P < .001) compared with controls. The esophagus was more reactive (P = .001) and less distensible (P = .04) in patients than controls. After NF, in patients with persistent symptoms, the sensory thresholds were unchanged (P > .05) but esophageal wall reactivity decreased (P = .001), and distensibility improved (P = .025).
  
  
  CONCLUSIONS
  NF improves esophageal biomechanical dysfunction but not the underlying hypersensitivity. Visceral hypersensitivity of the esophagus may explain persistent symptoms after NF.
authors.affiliation: Section of Neurogastroenterology, Division of Gastroenterology-Hepatology, Department of Internal Medicine, University of Iowa Carver College of Medicine, 200 Hawkins Dr, 4612 JCP, Iowa City, IA 52242, USA.
authors.forename: Jose M
authors.initials: JM
authors.lastname: Remes-Troche
authors.forename: James
authors.initials: J
authors.lastname: Maher
authors.forename: Ranjit
authors.initials: R
authors.lastname: Mudipalli
authors.forename: Satish S C
authors.initials: SS
authors.lastname: Rao
mesh_terms: D000328:Adult; D001696:Biomechanical Phenomena; D004947:Esophagus / Q000503:physiopathology*; D005260:Female; D018662:Fundoplication / Q000009:adverse effects*; D005764:Gastroesophageal Reflux / Q000209:etiology / Q000503:physiopathology* / Q000601:surgery; D006801:Humans; D010535:Laparoscopy; D008297:Male; D008875:Middle Aged