[Sweet's syndrome associated with squamous cell bronchial carcinoma. Neutrophilic dermatosis and non-small cell lung cancer].
BACKGROUND
Sweet's syndrome, one of the neutrophilic dermatoses, is idiopathic in most cases. In 10-20% of cases it is paraneoplastic, associated with a solid tumour or haematological malignancy. An association with carcinoma of the bronchus has been only rarely described.


METHODS
We report the case of a 56 year old man who presented with Sweet's syndrome two months before the diagnosis of a squamous cell carcinoma of the bronchus. The dermatosis responded well to corticosteroids. The progress of the tumour was favourable, with stabilisation following 3 courses of chemotherapy and local radiotherapy.


CONCLUSIONS
This case report updates this rare association and underlines the importance of undertaking appropriate thoracic investigations in the presence of this dermatosis. A paraneoplastic secretion of interleukin-8, GM-CSF and/or G-CSF by the bronchial tumour cells facilitating the recruitment of neutrophils, particularly in the skin, may account for the pathophysiology of this condition.
Van Denhove
A
A
Service de Pneumologie, Centre Hospitalier Lyon Sud, HCL, France.
Freymond
N
N
Isaac
S
S
Marrou
K
K
Balme
B
B
Gormand
F
F
Guibert
B
B
Pacheco
Y
Y
Devouassoux
G
G
D001984:Bronchial Neoplasms / Q000150:complications*; D002289:Carcinoma, Non-Small-Cell Lung / Q000150:complications*; D002294:Carcinoma, Squamous Cell / Q000150:complications*; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications*; D008297:Male; D008875:Middle Aged; D010257:Paraneoplastic Syndromes / Q000209:etiology*; D016463:Sweet Syndrome / Q000209:etiology*