High-viscosity hydroxypropylmethylcellulose blunts postprandial glucose and insulin responses.
OBJECTIVE
High-viscosity hydroxypropylmethylcellulose (HV-HPMC) is a modified cellulose fiber that produces a viscous gel in the gastrointestinal tract. Clinical trials demonstrate that consumption of HV-HPMC significantly lowers cholesterol, but limited information has been available on the influence of HV-HPMC on postprandial insulin and glucose responses. The objective of this investigation was to assess the influence of HV-HPMC on postprandial glucose and insulin responses in overweight and obese men and women.


METHODS
Participants were 31 overweight or obese men and women without diabetes who underwent three breakfast meal tests in random order, separated by > or = 72 h. Test meals containing 75 g carbohydrate plus 4 or 8 g HV-HPMC or control meals containing 8 g cellulose were delivered in a double-blind fashion.


RESULTS
Peak glucose was significantly lower (P < 0.001) after both HV-HPMC-containing meals (7.4 mmol/l [4 g] and 7.4 mmol/l [8 g]) compared with the control meal (8.6 mmol/l). Peak insulin concentrations and the incremental areas for glucose and insulin from 0 to 120 min were also significantly reduced after both HV-HPMC doses versus control (all P < 0.01).


CONCLUSIONS
These findings indicate that HV-HPMC consumption reduces postprandial glucose and insulin excursions, which may favorably alter risks for diabetes and cardiovascular disease.
Maki
Kevin C
KC
Provident Clinical Research, 1000 W. 1st St., Bloomington, IN 47403, USA. kmaki@providentcrc.com
Carson
Michael L
ML
Miller
Marvin P
MP
Turowski
Maciej
M
Bell
Marjorie
M
Wilder
Donna M
DM
Reeves
Matthew S
MS
D000293:Adolescent; D000328:Adult; D019540:Area Under Curve; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism*; D004311:Double-Blind Method; D004435:Eating; D005260:Female; D006801:Humans; D065347:Hypromellose Derivatives; D007328:Insulin / Q000097:blood* / Q000378:metabolism; D000078790:Insulin Secretion; D008297:Male; D008747:Methylcellulose / Q000031:analogs & derivatives* / Q000494:pharmacology; D008875:Middle Aged; D009765:Obesity / Q000503:physiopathology*; D009883:Ophthalmic Solutions / Q000494:pharmacology*; D019518:Postprandial Period; D014783:Viscosity
D001786:Blood Glucose; D007328:Insulin; D009883:Ophthalmic Solutions; D065347:Hypromellose Derivatives; D008747:Methylcellulose