title: Oophorectomy in premenopausal women: health-related quality of life and sexual functioning.
abstract: OBJECTIVE
  To compare health-related quality-of-life outcomes and sexual functioning among premenopausal women who underwent bilateral salpingo-oophorectomy (BSO) versus ovarian conservation at the time of hysterectomy.
  
  
  METHODS
  This is a secondary data analysis of premenopausal women who underwent hysterectomy for benign gynecologic disease in the Medicine or Surgery and the Total or Supracervical Hysterectomy randomized trials. Bilateral salpingo-oophorectomy was performed at the patients' requests or to treat intraoperative ovarian pathology. Health-related quality-of-life outcomes and sexual functioning were assessed using the Medical Outcomes Study SF-36, Sexual Problems Scales, and several other measures at 4 weeks, 6 months, and 2 years after hysterectomy.
  
  
  RESULTS
  Mean age at hysterectomy was higher for the 49 women who underwent BSO compared with the 112 women with ovarian conservation (45 versus 40, P<.001). At 6 months, the BSO group demonstrated less improvement than women with ovarian conservation on scales for body image (2 versus 14, P=.01), sleep problems (4 versus 16, P<.01), and the SF-36 Mental Component Summary (4 versus 10, P=.03). There were no differences in any measure of sexual functioning between the groups. Hot flushes, urinary incontinence, and pelvic pain were similar in both groups. At 2-year follow-up, all measures of health-related quality-of-life and sexual functioning appeared similar by BSO status.
  
  
  CONCLUSIONS
  Women who underwent BSO had less improvement in some aspects of health-related quality of life within the first 6 months following hysterectomy compared to women with ovarian conservation. However, these differences were not apparent 2 years after surgery.
  
  
  METHODS
  II.
authors.affiliation: Veterans Administration Medical Center, 4150 Clement Street, San Francisco, CA 94121, USA. teplinv@obgyn.ucsf.edu
authors.forename: Vanessa
authors.initials: V
authors.lastname: Teplin
authors.forename: Eric
authors.initials: E
authors.lastname: Vittinghoff
authors.forename: Feng
authors.initials: F
authors.lastname: Lin
authors.forename: Lee A
authors.initials: LA
authors.lastname: Learman
authors.forename: Holly E
authors.initials: HE
authors.lastname: Richter
authors.forename: Miriam
authors.initials: M
authors.lastname: Kuppermann
mesh_terms: D000328:Adult; D000367:Age Factors; D001828:Body Image; D005260:Female; D005500:Follow-Up Studies; D006304:Health Status; D006801:Humans; D007044:Hysterectomy; D007989:Libido; D008875:Middle Aged; D010052:Ovariectomy / Q000523:psychology*; D017697:Premenopause; D011788:Quality of Life; D012725:Sexual Behavior; D016896:Treatment Outcome