title: Inter-laboratory comparison of elemental analysis and gas chromatography combustion isotope ratio mass spectrometry (GC-C-IRMS). Part I: delta13C measurements of selected compounds for the development of an isotopic Grob-test.
abstract: This study was directed towards investigating suitable compounds to be used as stable isotope reference materials for gas chromatography combustion isotope ratio mass spectrometry (GC-C-IRMS) calibration. Several compounds were selected from those used in the 'Grob-test' mixture. Oxygen- and nitrogen-containing substances were added to these compounds to allow the mixture to be used as a possible multi-isotopic calibration tool for 2H/1H, 13C/12C, 15N/14N and 18O/16O ratio determinations. In this paper we present the results of delta13C measurements performed by the consortium of the five laboratories taking part in this inter-calibration exercise. All the compounds were individually assessed for homogeneity, short-term stability and long-term stability by means of EA-IRMS, as required by the bureau communitaire de reference (BCR) Guide for Production of Certified Reference Materials. The results were compared then with the GC-C-IRMS measurements using both polar and non-polar columns, and the final mixture of selected compounds underwent a further certification exercise assessing limits of accuracy and reproducibility under specified GC-C-IRMS conditions.
authors.affiliation: European Commission, Joint Research Centre, Institute for Health and Consumer Protection, Physical and Chemical Exposure Unit, BEVABS, 21020 Ispra (VA), Italy. francesca.serra@jrc.it
authors.forename: F
authors.initials: F
authors.lastname: Serra
authors.forename: A
authors.initials: A
authors.lastname: Janeiro
authors.forename: G
authors.initials: G
authors.lastname: Calderone
authors.forename: J M Moreno
authors.initials: JM
authors.lastname: Rojas
authors.forename: C
authors.initials: C
authors.lastname: Rhodes
authors.forename: L A
authors.initials: LA
authors.lastname: Gonthier
authors.forename: F
authors.initials: F
authors.lastname: Martin
authors.forename: M
authors.initials: M
authors.lastname: Lees
authors.forename: A
authors.initials: A
authors.lastname: Mosandl
authors.forename: S
authors.initials: S
authors.lastname: Sewenig
authors.forename: U
authors.initials: U
authors.lastname: Hener
authors.forename: B
authors.initials: B
authors.lastname: Henriques
authors.forename: L
authors.initials: L
authors.lastname: Ramalho
authors.forename: F
authors.initials: F
authors.lastname: Reniero
authors.forename: A J
authors.initials: AJ
authors.lastname: Teixeira
authors.forename: C
authors.initials: C
authors.lastname: Guillou
mesh_terms: D002247:Carbon Isotopes / Q000737:chemistry* / Q000592:standards*; D005060:Europe; D005504:Food Analysis / Q000592:standards*; D008401:Gas Chromatography-Mass Spectrometry / Q000592:standards*; D007753:Laboratories / Q000592:standards*; D012016:Reference Values
chemical_list: D002247:Carbon Isotopes