title: One-step synthesis of alpha-chloro acetophenones from acid chlorides and aryl precursors.
abstract: A direct and efficient method was developed for the preparation of a variety of substituted acetophenone derivatives from readily available arene precursors and acid chlorides. This method has significant generality and affords access to substitution patterns on aryl rings not directly achievable by Friedel-Crafts chemistry. [reaction: see text].
authors.affiliation: Merck & Company, Inc., Department of Process Research, P.O. Box 2000, Rahway, New Jersey 07065, USA. jonathan_rosen@merck.com
authors.forename: Jonathan
authors.initials: J
authors.lastname: Rosen
authors.forename: Dietrich
authors.initials: D
authors.lastname: Steinhuebel
authors.forename: Michael
authors.initials: M
authors.lastname: Palucki
authors.forename: Ian
authors.initials: I
authors.lastname: Davies
mesh_terms: D000098:Acetophenones / Q000138:chemical synthesis*; D000215:Acylation; D002384:Catalysis; D002712:Chlorides / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D003300:Copper / Q000737:chemistry; D017967:Zinc Compounds / Q000737:chemistry
chemical_list: D000098:Acetophenones; D002712:Chlorides; D017967:Zinc Compounds; D003300:Copper; C016837:zinc chloride