New diphenyl ethers from the insect pathogenic fungus Cordyceps sp. BCC 1861.
Two novel diphenyl ether glycosides and a new diphenyl ether, cordyol A-C (1-3), were isolated from the insect pathogenic fungus Cordyceps sp. BCC 1861. Structures of these compounds were elucidated by NMR and MS spectral analyses. Cordyol C (3) exhibited significant anti-HSV-1 activity with an IC50 value of 1.3 microg/ml, and cytotoxic activity against BC and NCI-H187 cancer cell lines with IC50 values of 8.65 and 3.72 microg/ml, respectively. Cordyol A (1) displayed weak antimycobacterial activity with a MIC value of 100 microg/ml.
Bunyapaiboonsri
Taridaporn
T
National Center for Genetic Engineering and Biotechnology (BIOTEC), Klong Luang, Pathumthani, Thiland. taridaporn@biotech.or.th
Yoiprommarat
Seangaroon
S
Intereya
Kamolphan
K
Kocharin
Kanokarn
K
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000494:pharmacology*; D045744:Cell Line, Tumor; D032661:Cordyceps / Q000737:chemistry* / Q000472:pathogenicity; D020128:Inhibitory Concentration 50; D007313:Insecta / Q000382:microbiology*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010647:Phenyl Ethers / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D010647:Phenyl Ethers; C031538:phenyl ether