title: [Whipple's disease].
abstract: Whipple's disease is a rare infectious disorder affecting mostly middle aged men. The causative organism, Tropheryma whipplei, recently has been cultivated and phylogenetically identified as an actinomycete. The rareness of the disease despite the ubiquitous occurence of T. whipplei presumably is related to a predisposing defect in cellular immunity. The diagnosis usually can be established by small bowel biopsy, but is frequently delayed due to protean clinical manifestations. The initiation of antibiotic treatment in most cases results in clinical remission, however, a significant number of patients is refractory to antimicrobial therapy or has a relapsing course.
authors.affiliation: Abteilung Innere Medizin, St. Josef Krankenhaus Zell. t.marth@krankenhaus-zell.de
authors.forename: T
authors.initials: T
authors.lastname: Marth
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use; D001706:Biopsy; D020682:Cefixime / Q000008:administration & dosage / Q000627:therapeutic use; D002443:Ceftriaxone / Q000008:administration & dosage / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D004318:Doxycycline / Q000008:administration & dosage / Q000627:therapeutic use; D004386:Duodenum / Q000473:pathology; D006801:Humans; D007413:Intestinal Mucosa / Q000473:pathology; D007583:Jejunum / Q000473:pathology; D008297:Male; D000077731:Meropenem; D008875:Middle Aged; D012008:Recurrence; D012074:Remission Induction; D012189:Retrospective Studies; D013845:Thienamycins / Q000008:administration & dosage / Q000627:therapeutic use; D013997:Time Factors; D016896:Treatment Outcome; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000008:administration & dosage / Q000627:therapeutic use; D008061:Whipple Disease / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology / Q000473:pathology
chemical_list: D000900:Anti-Bacterial Agents; D013845:Thienamycins; D002443:Ceftriaxone; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D020682:Cefixime; D000077731:Meropenem; D004318:Doxycycline