Prophylactic use of noninvasive ventilation in patients undergoing lung resectional surgery.
OBJECTIVE
We studied whether prophylactic use of noninvasive pressure support ventilation (NIPSV) administered pre- and postoperatively may reduce the postoperative pulmonary function impairment.


METHODS
Prospective randomized clinical trial. Thirty-nine patients with a preoperative FEV(1) <70% of the predicted value scheduled for elective lobectomy related to lung cancer were enrolled. Seven patients were excluded after enrollment. Patients were required to follow standard treatment without (control group, n=18) or with NIPSV (study group, n=14) during 7 days at home before surgery, and during 3 days postoperatively. Primary outcome variable was the changes on arterial blood gases on room air.


RESULTS
Two hours after surgery, PaO(2), FVC and FEV(1) values were significantly better in the NIPSV group. On day 1, 2 and 3, PaO(2) was significantly improved in the NIPSV group. Also on day 1, FVC and FEV(1) improved significantly in the NIPSV group. The hospital stay was significantly longer in the control group than in the study group (p=0.04). The incidence of major atelectasis was 14.2% in the NIPSV group and 38.9% in the no-NIPSV group (p=0.15). ANSWER TO THE QUESTION: Prophylactic use of NIPSV in a pre- and postoperative manner significantly reduces pulmonary dysfunction after lung resection. As a result, recovery of preoperative respiratory function is accelerated.
Perrin
Christophe
C
Service de Pneumologie, Centre Hospitalier et Universitaire de Nice, France. c.perrin@ch-cannes.fr
Jullien
Valérie
V
Vénissac
Nicolas
N
Berthier
Frédéric
F
Padovani
Bernard
B
Guillot
Françoise
F
Coussement
Alain
A
Mouroux
Jérôme
J
D000368:Aged; D002245:Carbon Dioxide / Q000097:blood; D005541:Forced Expiratory Volume; D006801:Humans; D008175:Lung Neoplasms / Q000601:surgery; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D010313:Partial Pressure; D019990:Perioperative Care / Q000379:methods*; D011013:Pneumonectomy / Q000009:adverse effects*; D011175:Positive-Pressure Respiration / Q000379:methods*; D012120:Respiration Disorders / Q000209:etiology / Q000517:prevention & control*; D014797:Vital Capacity
D002245:Carbon Dioxide; D010100:Oxygen