title: Pathophysiological roles of ASK1-MAP kinase signaling pathways.
abstract: Apoptosis signal-regulating kinase 1 (ASK1) is a mitogenactivated protein kinase (MAPK) kinase kinase that activates JNK and p38 kinases. ASK1 is activated by various stresses, such as reactive oxygen species (ROS), endoplasmic reticulum (ER) stress, lipopolysaccharide (LPS) and calcium influx which are thought to be responsible for the pathogenesis or exacerbations of various human diseases. Recent studies revealed the involvement of ASK1 in ROS- or ER stressrelated diseases, suggesting that ASK1 may be a potential therapeutic target of various human diseases. In this review, we focus on the current findings for the relationship between pathogenesis and ASK1-MAPK pathways.
authors.affiliation: Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Japan.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Nagai
authors.forename: Takuya
authors.initials: T
authors.lastname: Noguchi
authors.forename: Kohsuke
authors.initials: K
authors.lastname: Takeda
authors.forename: Hidenori
authors.initials: H
authors.lastname: Ichijo
mesh_terms: D000818:Animals; D004194:Disease / Q000209:etiology*; D006801:Humans; D007107:Immune System / Q000502:physiology; D048848:MAP Kinase Kinase Kinase 5 / Q000502:physiology*; D020935:MAP Kinase Signaling System / Q000502:physiology*; D008954:Models, Biological; D019636:Neurodegenerative Diseases / Q000209:etiology; D018384:Oxidative Stress
chemical_list: D048848:MAP Kinase Kinase Kinase 5