Anxiolytic effects of erythrinian alkaloids from Erythrina mulungu.
One new erythrinian alkaloid derivative, (+)-11alpha-hydroxyerythravine (1), and the known (+)-erythravine (2) and (+)-alpha-hydroxyerysotrine (3) were isolated from the flowers of Erythrina mulungu. Their structures were determined by spectroscopic/spectrometric data interpretation of 1H, 13C, and 2D NMR and MS experiments. The relative configuration was established by NOESY analysis, while the conformation adopted by these molecules was evaluated through molecular modeling studies and coupling constants obtained by NMR analysis. Furthermore, the anxiolytic effects of the E. mulungu aqueous alcoholic crude extract and of the purified alkaloids were evaluated using the elevated T-maze test.
Flausino
Otavio
O
Department of Psychobiology, FFCLRP, University of São Paulo, Avenida Bandeirantes, 3900, 14040-901 Ribeirão Preto, SP, Brazil.
Santos
Luciana de Avila
Lde A
Verli
Hugo
H
Pereira
Ana Maria
AM
Bolzani
Vanderlan da Silva
Vda S
Nunes-de-Souza
Ricardo Luiz
RL
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D014151:Anti-Anxiety Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001938:Brazil; D004895:Erythrina / Q000737:chemistry*; D035264:Flowers / Q000737:chemistry; D006576:Heterocyclic Compounds, 4 or More Rings / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008297:Male; D051379:Mice; D019906:Nuclear Magnetic Resonance, Biomolecular; D010946:Plants, Medicinal / Q000737:chemistry*
C517703:(+)-11alpha-hydroxyerythravine; C517705:(+)-alpha-hydroxyerysotrine; C517704:(+)-erythravine; D000470:Alkaloids; D014151:Anti-Anxiety Agents; D006576:Heterocyclic Compounds, 4 or More Rings