Cytotoxic sterols from the formosan brown alga Turbinaria ornata.
Two hydroperoxysterols 24-hydroperoxy-24-vinyl-cholesterol (1) and 29-hydroperoxystigmasta-5,24(28)-dien-3beta-ol (2), and fucosterol (3) were isolated from the brown alga Turbinaria ornata (Sargassaceae). Hydroperoxide 2 is a new natural compound and was converted into 29-hydroxystigmasta-5,24 (28)-dien-3beta-ol (4) by reaction with LAH. Sterols 1, 2, and 4 exhibited cytotoxicity against various cancer cell lines.
Sheu
J H
JH
Wang
G H
GH
Sung
P J
PJ
Chiu
Y H
YH
Duh
C Y
CY