Analysis of pulmonary mechanics in an experimental model of sepsis.
OBJECTIVE
To determine whether pulmonary mechanics are altered in mice with sepsis.


METHODS
A total of 40 Balb/c mice were divided into two groups: survival (n = 21) and pulmonary mechanics (n = 19). The survival group was divided into three subgroups: control (n = 7), sublethal (n = 7) and lethal (n = 7). The pulmonary mechanics group was also divided into three subgroups: control (n = 5), sublethal (n = 7) and lethal (n = 7). Sepsis was induced through cecal ligation and puncture, the latter varying in degree (sublethal or lethal). At eight hours after the intervention, pulmonary mechanics were measured through end-inflation occlusion. In the pulmonary mechanics group, the following variables were studied: total pressure, resistance, viscoelasticity, dynamic compliance and static compliance. The data obtained were analyzed using one-way ANOVA.


RESULTS
The data for the survival group indicate the efficacy of the model employed. There were no statistically significant differences among the pulmonary mechanics subgroups in terms of dynamic compliance, static compliance, total pressure, resistance or viscoelasticity.


CONCLUSIONS
At eight hours after cecal ligation and puncture, there were no changes in the lung parenchyma, nor were any alterations observed in the viscous and viscoelastic components of the lung.
Carvalho
Rodrigo Storck
RS
Universidade de Brasília, Brasília, DF, Brasil. rodrigo.storck@terra.com.br
de Pinho
André Gustavo Magalhães
AG
de Andrade
Ana Paula Alves
AP
Silva
César Augusto Melo E
CA
Gaio
Carlos Eduardo
CE
Tavares
Paulo
P
D000818:Animals; D002432:Cecum; D004195:Disease Models, Animal; D008026:Ligation; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D011677:Punctures; D012129:Respiratory Function Tests; D015656:Respiratory Mechanics / Q000502:physiology*; D018805:Sepsis / Q000401:mortality / Q000503:physiopathology*