title: Rapid effector function of varicella-zoster virus glycoprotein I-specific CD4+ T cells many decades after primary infection.
abstract: Glycoprotein I (gI) of varicella-zoster virus (VZV) contributes to viral virulence and is therefore a potentially important target for T cell control of viral replication. Persisting effector function of gI-specific T cells after primary infection has not been previously examined. We have shown that, many decades after infection, relatively high frequencies gI-specific interferon- gamma responses are detectable ex vivo and are dominated by CD4(+) T cells. We characterized the optimal peptide of the strongest response in our cohort showing restriction through DRB4*01. These findings are consistent with gI-specific CD4(+) T cell involvement in the control of VZV replication.
authors.affiliation: Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom.
authors.forename: Gathsaurie Neelika
authors.initials: GN
authors.lastname: Malavige
authors.forename: Louise
authors.initials: L
authors.lastname: Jones
authors.forename: Antony Paul
authors.initials: AP
authors.lastname: Black
authors.forename: Graham Stuart
authors.initials: GS
authors.lastname: Ogg
mesh_terms: D000328:Adult; D015496:CD4-Positive T-Lymphocytes / Q000187:drug effects* / Q000378:metabolism*; D018414:CD8-Positive T-Lymphocytes / Q000378:metabolism; D002478:Cells, Cultured; D002644:Chickenpox / Q000276:immunology*; D014645:Herpesvirus 3, Human / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D007371:Interferon-gamma / Q000378:metabolism; D007963:Leukocytes, Mononuclear / Q000378:metabolism; D014759:Viral Envelope Proteins / Q000378:metabolism / Q000494:pharmacology*
chemical_list: D014759:Viral Envelope Proteins; C056913:glycoprotein E, varicella-zoster virus; D007371:Interferon-gamma