Inhibitory effects of methyl brevifolincarboxylate isolated from Phyllanthus niruri L. on platelet aggregation.
A platelet-aggregatory inhibitor was isolated from the 50% MeOH extract of Phyllanthus niruri L. leaf. Its structure was determined to be methyl brevifolincarboxylate on the basis of the 1H-, 13C-NMR, and high-resolution mass spectral data. We compared the antiplatelet aggregatory effects of the constituent with adenosine, a well-known inhibitor of platelet aggregation. Platelet aggregation was induced by collagen or adenosine 5'-diphosphate as an activating agent; the extent of inhibition was monitored with a platelet aggregometer employing a laser-scattering method. The inhibitory effects of methyl brevifolincarboxylate were found to be as potent as adenosine that is known to act on an A2A subtype receptor.
Iizuka
Toru
T
Faculty of Pharmaceutical Sciences, Hoshi University, Tokyo, Japan. iizuka@hoshi.ac.jp
Nagai
Masahiro
M
Taniguchi
Akemi
A
Moriyama
Hiroyoshi
H
Hoshi
Keiko
K
D001578:Benzopyrans / Q000302:isolation & purification / Q000494:pharmacology*; D001792:Blood Platelets / Q000187:drug effects; D006801:Humans; D029803:Phyllanthus / Q000737:chemistry*; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000302:isolation & purification / Q000494:pharmacology*
D001578:Benzopyrans; D010975:Platelet Aggregation Inhibitors; C087786:methyl brevifolincarboxylate