Fixed drug eruption due to ibuprofen.
Fixed drug eruptions due to ibuprofen have rarely been reported. Two days after treatment with ibuprofen, a 61-year-old woman developed erythema and pain affecting the tongue and oral mucosa. Two months later, the patient started ibuprofen and erythromycin for a catarrhal episode with reappearance of the same lesions in the oral mucosa 24 hours later. Furthermore, two new erythematosus-violaceous maculae developed. Topical challenge through an occluded patch test with ibuprofen 5% on the residual cutaneous lesion was successful. We present an unusual case of fixed drug eruption due to ibuprofen
Alvarez Santullano
C Villanueva
CV
MIR 3, Unidad de Alergia, Hospital Gregorio Marañón, Madrid, Spain.
Tover Flores
V
V
De Barrio Fernández
M
M
Tornero Molina
P
P
Prieto Garcia
A
A
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D003875:Drug Eruptions / Q000175:diagnosis / Q000209:etiology*; D005260:Female; D006801:Humans; D007052:Ibuprofen / Q000009:adverse effects*; D008875:Middle Aged; D009061:Mouth Mucosa / Q000187:drug effects; D010328:Patch Tests; D013280:Stomatitis / Q000139:chemically induced*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007052:Ibuprofen