Sub-foveal choroidal blood flow by LDF: measurement and application to the physiology and pathology of the choroidal circulation.
Laser Doppler flowmetry allows the measurement of relative choroidal blood flow in the sub-foveal region of the fundus (ChBF). This technique has been applied to the investigation of the regulation of ChBF in response to a variety of physiological stimuli (breathing different gas mixtures of O2 and CO2, varying the systemic and ocular blood perfusion pressures, light-dark transition and zero gravity) in normal subjects. Measurements in pathological conditions, such as diabetes, age-related macular degeneration and glaucoma indicate alterations of the response of ChBF to increased systemic blood pressure. The data provide a better understanding of the regulation of the choroidal circulation in the normal and diseased eye.
Riva
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Institut de Recherche en Ophtalmologie, Sion, Switzerland. charles.riva@netplus.ch
D000280:Administration, Inhalation; D000818:Animals; D002245:Carbon Dioxide / Q000008:administration & dosage; D002829:Choroid / Q000098:blood supply*; D003930:Diabetic Retinopathy / Q000503:physiopathology; D005584:Fovea Centralis; D005901:Glaucoma / Q000503:physiopathology; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology; D017078:Laser-Doppler Flowmetry; D008027:Light; D008268:Macular Degeneration / Q000503:physiopathology; D015879:Myosin Subfragments; D010100:Oxygen / Q000008:administration & dosage; D011187:Posture / Q000502:physiology; D012039:Regional Blood Flow; D012119:Respiration; D014893:Weightlessness
D015879:Myosin Subfragments; D002245:Carbon Dioxide; D010100:Oxygen