Optimization of a miniature Maglev ventricular assist device for pediatric circulatory support.
A miniature Maglev blood pump based on magnetically levitated bearingless technology is being developed and optimized for pediatric patients. We performed impeller optimization by characterizing the hemodynamic and hemocompatibility performances using a combined computational and experimental approach. Both three-dimensional flow features and hemolytic characteristics were analyzed using computational fluid dynamics (CFD) modeling. Hydraulic pump performances and hemolysis levels of three different impeller designs were quantified and compared numerically. Two pump prototypes were constructed from the two impeller designs and experimentally tested. Comparison of CFD predictions with experimental results showed good agreement. The optimized impeller remarkably increased overall pump hydraulic output by more than 50% over the initial design. The CFD simulation demonstrated a clean and streamlined flow field in the main flow path. The numerical results by hemolysis model indicated no significant high shear stress regions. Through the use of CFD analysis and bench-top testing, the small pediatric pump was optimized to achieve a low level of blood damage and improved hydraulic performance and efficiency. The Maglev pediatric blood pump is innovative due to its small size, very low priming volume, excellent hemodynamic and hematologic performance, and elimination of seal-related and bearing-related failures due to adoption of magnetically levitated bearingless motor technology, making it ideal for pediatric applications.
Zhang
Juntao
J
Artificial Organs Laboratory, Department of Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Koert
Andrew
A
Gellman
Barry
B
Gempp
Thomas M
TM
Dasse
Kurt A
KA
Gilbert
Richard J
RJ
Griffith
Bartley P
BP
Wu
Zhongjun J
ZJ
D002648:Child; D004867:Equipment Design; D006353:Heart-Assist Devices; D006461:Hemolysis; D006801:Humans; D008904:Miniaturization; D011312:Pressure