Feroniellin B, a new highly potent human platelet aggregation inhibitor from Feroniella lucida.
Human platelet aggregation inhibition by coumarins isolated from Feroniella lucida roots extract was investigated. Of 11 coumarins examined, feroniellin B highly inhibited platelet aggregation induced by ADP with an IC(50) value of 0.287 mm while the standard drug ibuprofen displayed this inhibition with an IC(50) value of 11.2 mm. The presence of feroniellin B is possibly linked to the ethnopharmacological use of F. lucida as a remedy for cardiovascular diseases.
Phuwapraisirisan
Preecha
P
Natural Products Research Unit, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand. preecha.p@chula.ac.th
Surapinit
Serm
S
Jeenapongsa
Rattima
R
Tip-pyang
Santi
S
Kokpol
Udom
U
D003374:Coumarins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D018517:Plant Roots / Q000737:chemistry; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D027821:Rutaceae / Q000737:chemistry*
D003374:Coumarins; D005663:Furans; D010975:Platelet Aggregation Inhibitors; C520905:feroniellin B