[Thyroid carcinoma. A descriptive retrospective study].
The thyroid carcinoma (TC) is not very frequent among all cancers. Its course is slow and is high potentially curable. Our aim was to analyse the characteristics in patients with TC. A retrospective analysis on 171 patients, with an average age of 41.1 (+/- 14.6), who asked for TC to our service between the years 2000-04, was performed. From case histories it was evaluated: anamnesis, diagnostic image, histopathology and evolution. Tumours were grouped for size and TNM (tumour-nodule-metastasis) in stages (S). A stimulated serum thyroglobulin level >2 ng/ml and positive image with 131I or another nuclear marker were considered as positive for residual TC. In the totality of the analyzed patients 88% were female, 62% below 45 years old, and in 77% the thyroid function was normal. The fine needle aspiration (FNA) was diagnostic in 78%. Papillary thyroid carcinoma (PTC) in 96%. The 63% was SI; 14% SII; 19% SIII and 4% SIV. During follow-up, we observed that 90% of patients with Tg between 2 and 10 had evidence of residual TC, and 100% with Tg >10 ng/ml, whereas 18% of those whose stimulated Tg <2 presented positive image. There was not found significative correlation with pathologic antecedents or relevant image signs.


CONCLUSIONS
TCP was the most frequent carcinoma in women, in patients younger than 45 years and in those who have euthyroid function. A stimulated serum thyroglobulin level was a good indicator for residual TC, but failed to select those patients who were disease free.
Gonzalez
Carolina C
CC
Servicio de Endocrinologia, Hospital Privado de Córdoba, Naciones Unidas 346, 5016 Córdoba, Argentina. carogz@argentina.com
Yaniskowski
Maria Lucy
ML
Wyse
Eduardo P
EP
Giovannini
Andrea A
AA
Lopez
Monica B
MB
Wior
Myriam E
ME
D000328:Adult; D014408:Biomarkers, Tumor / Q000097:blood; D002291:Carcinoma, Papillary / Q000097:blood / Q000473:pathology*; D005260:Female; D006044:Goiter, Nodular / Q000097:blood / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D018365:Neoplasm, Residual; D011379:Prognosis; D012189:Retrospective Studies; D012737:Sex Factors; D013954:Thyroglobulin / Q000097:blood; D013964:Thyroid Neoplasms / Q000097:blood / Q000473:pathology*; D016606:Thyroid Nodule / Q000097:blood / Q000473:pathology; D013972:Thyrotropin / Q000097:blood
D014408:Biomarkers, Tumor; D013972:Thyrotropin; D013954:Thyroglobulin