[Effects of endocannabinoids on cardiovascular system].
Endocannabinoids and its corresponding receptors exist in myocardium, vascular smooth muscle cells, endothelial cells, nerve cells within blood vessel walls and some of circulating cells in blood. Endocannabinoids have different roles such as modulating blood pressure and vascular dilation in cardiovascular system in different models and organs of animal or human. It might mediate cardiac protection and modulating circulation in shock and myocardial infarction. Also, endocannabinoids might play a key role in cardiac preconditioning. The study of endocannabinoids in cardiovascular system was just start. We introduced the progress in the source and distribution of endocannabinoids in cardiovascular system, and the action and mechanisms of endocannabinoids in blood vessels and hearts in the present review.
Ma
Shi-Yu
SY
Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Ma
Ye-Xin
YX
D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D063385:Cannabinoid Receptor Modulators / Q000502:physiology*; D002320:Cardiovascular Physiological Phenomena; D063388:Endocannabinoids; D043882:Receptors, Cannabinoid / Q000502:physiology*
D063385:Cannabinoid Receptor Modulators; D063388:Endocannabinoids; D043882:Receptors, Cannabinoid