Vagus nerve stimulation for treatment-resistant depression: behavioral and neural effects on encoding negative material.
OBJECTIVE
Vagus nerve stimulation (VNS) can improve depression. Cognitive models of depression highlight an over-representation of negative thoughts and memories, with depressed individuals showing memory facilitation for negative material. We hypothesized that the antidepressant action of VNS may emerge through corrective influences on 'negativity bias' in memory. We therefore examined the impact of VNS on emotional memory and its underlying brain activity.


METHODS
We tested a single patient undergoing VNS for treatment-resistant depression (TRD). Stimulation was set at a 30/66-second on/off cycle during three encoding blocks when the patient viewed randomly presented positive, negative, and neutral words. Following each block, VNS was switched off and the patient identified previously seen words from distractors in a subsequent recognition memory task. The patient was scanned using functional magnetic resonance imaging (fMRI) during the first encoding block.


RESULTS
There was robust recall of negative material viewed during 'off' cycles of VNS but subsequent memory of negative words was attenuated during active VNS ('on' cycles). VNS did not influence memory for neutral and positive words. With neuroimaging, direct modulatory effects of VNS were observed in dorsomedial, dorsolateral, and orbital regions of the prefrontal cortex. Moreover, during encoding of negative words, compared with positive and neutral words, VNS also modulated activity within orbitofrontal, ventromedial and polar prefrontal cortices, midcingulate cortex, and brain stem.


CONCLUSIONS
Our observations show that VNS can interfere with memory of negative information, an effect that may contribute to its antidepressant role. Neuroimaging implicated regions including the ventral and medial prefrontal cortex as an underlying neural substrate.
Critchley
Hugo D
HD
Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, Queen Square, London, UK. H.Critchley@bsms.ac.uk
Lewis
Penelope A
PA
Orth
Michael
M
Josephs
Oliver
O
Deichmann
Ralf
R
Trimble
Michael R
MR
Dolan
Raymond J
RJ
D001921:Brain / Q000502:physiology; D003863:Depression / Q000523:psychology / Q000628:therapy*; D004599:Electric Stimulation Therapy; D004567:Electrodes, Implanted; D004644:Emotions; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008568:Memory; D008875:Middle Aged; D014630:Vagus Nerve / Q000502:physiology*