title: Predictors of recovery of ovarian function during weight gain in anorexia nervosa.
abstract: OBJECTIVE
  To investigate whether serum levels of follicle-stimulating hormone (FSH), inhibin B, and anti-Müllerian hormone (AMH) can be used as predictors of recovery of ovarian function in anorexia nervosa after weight gain.
  
  
  METHODS
  Follow-up cohort study.
  
  
  METHODS
  Two specialized treatment centers for eating disorders, one for adolescents (aged between 12 and 17 years) and one for adults (older than the age of 17 years).
  
  
  METHODS
  Sixty-one young women (mean age, 18.2 years) with anorexia nervosa.
  
  
  METHODS
  None (standard treatment program).
  
  
  METHODS
  Time to recovery of menses.
  
  
  RESULTS
  Forty-two (69%) patients recovered in weight within the 1st year, of which only 24 (39%) reached resumption of regular menstrual cycles. Next to weight gain itself, initial ovarian endocrine markers such as FSH, inhibin B, and AMH hormone were capable of predicting chances for resumption of menses in a multivariate analysis with time to recovery as the main outcome measure.
  
  
  CONCLUSIONS
  Initial ovarian endocrine markers FSH, inhibin B, and AMH can predict successful recovery of ovarian function in anorexia nervosa patients undergoing treatment to gain weight.
authors.affiliation: Rudolf Magnus Institute of Neuroscience: Department of Child and Adolescent Psychiatry, University Medical Center, Utrecht, The Netherlands. a.van.elburg@altrecht.nl <a.van.elburg@altrecht.nl>
authors.forename: Annemarie A
authors.initials: AA
authors.lastname: van Elburg
authors.forename: Marinus J C
authors.initials: MJ
authors.lastname: Eijkemans
authors.forename: Martien J H
authors.initials: MJ
authors.lastname: Kas
authors.forename: Axel P N
authors.initials: AP
authors.lastname: Themmen
authors.forename: Frank H
authors.initials: FH
authors.lastname: de Jong
authors.forename: Herman
authors.initials: H
authors.lastname: van Engeland
authors.forename: Bart C J M
authors.initials: BC
authors.lastname: Fauser
mesh_terms: D000293:Adolescent; D000856:Anorexia Nervosa / Q000503:physiopathology* / Q000523:psychology / Q000628:therapy; D054304:Anti-Mullerian Hormone; D015992:Body Mass Index; D002648:Child; D015331:Cohort Studies; D004958:Estradiol / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006023:Glycoproteins / Q000097:blood; D006801:Humans; D007265:Inhibins / Q000097:blood; D010053:Ovary / Q000503:physiopathology*; D013735:Testicular Hormones / Q000097:blood; D015430:Weight Gain
chemical_list: D006023:Glycoproteins; D013735:Testicular Hormones; C422364:inhibin B; D004958:Estradiol; D007265:Inhibins; D054304:Anti-Mullerian Hormone; D005640:Follicle Stimulating Hormone