title: Regulation of T-cell activation by the cytoskeleton.
abstract: To become activated, T cells must efficiently recognize antigen-presenting cells or target cells through several complex cytoskeleton-dependent processes, including integrin-mediated adhesion, immunological-synapse formation, cellular polarization, receptor sequestration and signalling. The actin and microtubule systems provide the dynamic cellular framework that is required to orchestrate these processes and ultimately contol T-cell activation. Here, we discuss recent advances that have furthered our understanding of the crucial importance of the T-cell cytoskeleton in controlling these aspects of T-cell immune recognition.
authors.affiliation: Department of Immunology, Mayo Clinic College of Medicine, 200 First Street South West, Rochester, Minnesota 55905, USA.
authors.forename: Daniel D
authors.initials: DD
authors.lastname: Billadeau
authors.forename: Jeffrey C
authors.initials: JC
authors.lastname: Nolz
authors.forename: Timothy S
authors.initials: TS
authors.lastname: Gomez
mesh_terms: D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology; D003599:Cytoskeleton / Q000276:immunology*; D006801:Humans; D008213:Lymphocyte Activation / Q000276:immunology*; D051379:Mice; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology*