[Expression and clinical significance of focal adhesion kinase in oral squamous cell carcinoma].
OBJECTIVE
To study the correlation between expression levels of focal adhesion kinase (FAK) in oral squamous cell carcinoma (OSCC) and clinical prognosis with pathologic parameters.


METHODS
Eighty paraffin embedded tissue specimens of OSCC were studied by immunohistochemistry. The data was analyzed by SPSS statistical software.


RESULTS
FAK was highly expressed in OSCC tissues, in contrast to none or a low expression in normal oral epithelial tissue, and the heterogeneous staining was mainly located in the cell membrane and cytoplasm. FAK overexpression significantly correlated with histological differentiation and TNM stage, lymphatic metastasis. Multivariate analysis revealed that overexpression of FAK was the independent prognostic factor.


CONCLUSIONS
The overexpression of FAK in the peripheral area of OSCC may serve as a useful biological factor affecting prognosis.
He
Zhi-Xiu
ZX
Department of Pathology, West China Stomatology Hospital, Sichuan University, Chengdu 610041, China.
He
Hua-Wei
HW
Wang
Dan
D
Fang
Mei-Xian
MX
D000293:Adolescent; D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D005260:Female; D051416:Focal Adhesion Protein-Tyrosine Kinases / Q000378:metabolism*; D005500:Follow-Up Studies; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D011379:Prognosis; D012044:Regression Analysis; D055815:Young Adult
D051416:Focal Adhesion Protein-Tyrosine Kinases