title: Cross-cultural dynamics in rural Peru.
abstract: Cross-cultural and language barriers can be an impediment to the conduct of biomedical studies in developing nations. To assess the implementation of human-use procedures within a minimum-risk febrile illness surveillance study in Peru, personnel fluent in both English and Spanish conducted a review of 10 sites. Guideline adherence, consent procedures, and potential problems in the conduct of the trial were reviewed. Concerns cited by on-site investigators included patient follow-up, poor facilities, and power fluctuations that jeopardized samples before shipment to a central location. However, both local study coordinators and patients demonstrated a clear grasp of study enrollment and consent procedures and reported no significant problems in the conduct of the study. These findings suggest that significant planning is crucial before initiation of biomedical studies in developing nations to successfully overcome physical challenges and cultural dynamics that could otherwise adversely affect scientific outcomes.
authors.affiliation: University of Wisconsin Medical School, Madison 53726, USA.
authors.forename: David A
authors.initials: DA
authors.lastname: Paz
authors.forename: Patrick J
authors.initials: PJ
authors.lastname: Blair
mesh_terms: D035843:Biomedical Research / Q000941:ethics*; D002983:Clinical Competence; D018864:Cultural Diversity; D003906:Developing Countries; D006801:Humans; D007258:Informed Consent; D038622:Internationality; D007802:Language; D008887:Military Medicine / Q000379:methods*; D008889:Military Personnel; D010568:Peru; D015397:Program Evaluation; D035844:Researcher-Subject Relations / Q000941:ethics; D003294:Seizures, Febrile / Q000175:diagnosis* / Q000453:epidemiology; D013577:Syndrome; D014481:United States