title: Seminal vesicle protein IV and its derived active peptides: a possible physiological role in seminal clotting.
abstract: Seminal vesicle protein 4 (SV-IV) is a highly flexible molecule that in aqueous solution behaves as a concentration-dependent self-associating system in which the degree of association (monomer <--> dimer <--> trimer equilibrium) seems to be related to its biological activities. This review reports the functional role of SV-IV in seminal clotting exerted through the modulation of inflammation, hemostasis, and sperm protection against the damage induced by immunological or reactive oxygen species during the long journey of spermatozoa in the female genital tract.
authors.affiliation: CNR, Institute of Genetics and Biophysics Adriano Buzzati-Traverso, Naples, Italy.
authors.forename: Salvatore
authors.initials: S
authors.lastname: Metafora
authors.forename: Carla
authors.initials: C
authors.lastname: Esposito
authors.forename: Ivana
authors.initials: I
authors.lastname: Caputo
authors.forename: Marilena
authors.initials: M
authors.lastname: Lepretti
authors.forename: Diana
authors.initials: D
authors.lastname: Cassese
authors.forename: Alessandra
authors.initials: A
authors.lastname: Dicitore
authors.forename: Pasquale
authors.initials: P
authors.lastname: Ferranti
authors.forename: Paola
authors.initials: P
authors.lastname: Stiuso
mesh_terms: D000818:Animals; D005260:Female; D006487:Hemostasis / Q000276:immunology; D006801:Humans; D007249:Inflammation / Q000276:immunology / Q000378:metabolism; D008297:Male; D010455:Peptides / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D011487:Protein Conformation; D017382:Reactive Oxygen Species / Q000276:immunology / Q000378:metabolism; D012661:Semen / Q000737:chemistry / Q000276:immunology* / Q000378:metabolism; D029607:Seminal Vesicle Secretory Proteins / Q000737:chemistry / Q000276:immunology* / Q000378:metabolism; D013094:Spermatozoa / Q000276:immunology / Q000378:metabolism; D013329:Structure-Activity Relationship
chemical_list: D010455:Peptides; D017382:Reactive Oxygen Species; D029607:Seminal Vesicle Secretory Proteins