title: TCF7L2 polymorphisms are associated with type 2 diabetes in northern Sweden.
abstract: A recent study found association of one microsatellite and five single nucleotide polymorphisms (SNPs) in intron 3 of the TCF7L2 gene with type 2 diabetes (T2D) in the Icelandic, Danish and American populations. The aim of the present study was to investigate if those SNPs were associated to T2D in two (family- and population-based) cohorts from northern Sweden. We genotyped four of the associated SNPs in a case-control cohort consisting of 872 T2D cases and 857 controls matched with respect to age, sex and geographical origin and in a sample of 59 extended families (148 affected and 83 unaffected individuals). Here, we report replication of association between T2D and three SNPs in the case-control (rs7901695, P=0.003; rs7901346, P=0.00002; and rs12255372, P=0.000004) and two SNPs in the family-based (rs7901695, P=0.01 and rs7901346, P=0.04) samples from northern Sweden. This replication strengthens the evidence for involvement of TCF7L2 in T2D.
authors.affiliation: Division of Medical and Clinical Genetics, Department of Medical Biosciences, Umeå University, Umeå, Sweden.
authors.forename: Sofia
authors.initials: S
authors.lastname: Mayans
authors.forename: Kurt
authors.initials: K
authors.lastname: Lackovic
authors.forename: Petter
authors.initials: P
authors.lastname: Lindgren
authors.forename: Karin
authors.initials: K
authors.lastname: Ruikka
authors.forename: Asa
authors.initials: A
authors.lastname: Agren
authors.forename: Mats
authors.initials: M
authors.lastname: Eliasson
authors.forename: Dan
authors.initials: D
authors.lastname: Holmberg
mesh_terms: D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D005190:Family; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D013548:Sweden; D051820:TCF Transcription Factors / Q000235:genetics*; D058118:Transcription Factor 7-Like 2 Protein
chemical_list: D051820:TCF Transcription Factors; C544894:TCF7L2 protein, human; D058118:Transcription Factor 7-Like 2 Protein