title: Long-lasting changes of albino rats behavior and brain bioamines content after immunization against cholecystokinin-3 and -4.
abstract: Active immunization against cholecystokinin fragments 31-33 (CCK-3) and 30-33 (CCK-4) results in long-lasting changes of albino rats' behavior. CCK-3 and CCK-4 covalently linked to antigen-carrier evokes the suppression of the anxiety, decreases some signs of depression-like behavior and changes the level of bioamines and their catabolites in striatum at least for two months after immunization. These data can provide a perspective approach to the problem of long term correction of behavior.
authors.affiliation: Department of Human Physiology, School of Biology, Moscow State University, Vorobiovy Gory, Moscow, Russia.
authors.forename: Igor Petrovich
authors.initials: IP
authors.lastname: Ashmarin
authors.forename: Raisa A
authors.initials: RA
authors.lastname: Danilova
authors.forename: Maria F
authors.initials: MF
authors.lastname: Obukhova
authors.forename: Olga Igorevna
authors.initials: OI
authors.lastname: Rud'ko
authors.forename: Ludmila A
authors.initials: LA
authors.lastname: Andreeva
mesh_terms: D000818:Animals; D001007:Anxiety / Q000276:immunology*; D001679:Biogenic Amines / Q000378:metabolism*; D001921:Brain / Q000378:metabolism*; D002766:Cholecystokinin / Q000276:immunology*; D003342:Corpus Striatum / Q000276:immunology / Q000378:metabolism; D007114:Immunization; D008297:Male; D009842:Oligopeptides / Q000276:immunology*; D051381:Rats; D017208:Rats, Wistar; D012149:Restraint, Physical; D013315:Stress, Psychological / Q000276:immunology; D013550:Swimming; D013758:Tetragastrin / Q000276:immunology*
chemical_list: D001679:Biogenic Amines; D009842:Oligopeptides; D013758:Tetragastrin; D002766:Cholecystokinin