title: Evaluation of cardiac abnormalities by Doppler echocardiography in a large nationwide multicentric cohort of patients with systemic sclerosis.
abstract: OBJECTIVE
  There is increasing concern about heart and pulmonary vascular involvement in systemic sclerosis (SSc). One of the most severe complications of SSc is pulmonary arterial hypertension (PAH). There has been an increased awareness of left ventricular (LV) diastolic abnormalities in SSc patients. However, previous studies have generally been conducted in small populations. The aims of this study were to prospectively screen for PAH and to describe echocardiographic parameters in a large group of SSc patients.
  
  
  METHODS
  This prospective study was conducted in 21 centres for SSc in France. Patients without severe pulmonary function abnormalities, severe cardiac disease and known PAH underwent Doppler echocardiography performed by a reference cardiologist.
  
  
  RESULTS
  Of the 570 patients evaluated, PAH was suspected in 33 patients and was confirmed in 18 by right heart catheterisation. LV systolic dysfunction was rare (1.4%). LV hypertrophy was found in 22.6%, with LV diastolic dysfunction in 17.7%. These LV abnormalities were influenced by age, gender and blood pressure. We identified a small group of 21 patients with a restrictive mitral flow pattern in the absence of any other cardiopulmonary diseases, suggesting a specific cardiac involvement in SSc.
  
  
  CONCLUSIONS
  Left and right heart diseases, including PAH, LV hypertrophy and diastolic dysfunction, are common in SSc. However, a small subset of patients without any cardiac or pulmonary diseases have a restrictive mitral flow pattern that could be due to primary cardiac involvement of SSc. The prognostic implications of the LV abnormalities will be evaluated in the 3-year follow-up of this cohort.
authors.affiliation: Hôpital Cardiologique, Service de Cardiologie C, Boulevard du Professeur Leclercq, CHRU, 59037 Lille Cedex, France. pdegroote@chru-lille.fr
authors.forename: P
authors.initials: P
authors.lastname: de Groote
authors.forename: V
authors.initials: V
authors.lastname: Gressin
authors.forename: E
authors.initials: E
authors.lastname: Hachulla
authors.forename: P
authors.initials: P
authors.lastname: Carpentier
authors.forename: L
authors.initials: L
authors.lastname: Guillevin
authors.forename: A
authors.initials: A
authors.lastname: Kahan
authors.forename: J
authors.initials: J
authors.lastname: Cabane
authors.forename: C
authors.initials: C
authors.lastname: Francès
authors.forename: N
authors.initials: N
authors.lastname: Lamblin
authors.forename: E
authors.initials: E
authors.lastname: Diot
authors.forename: F
authors.initials: F
authors.lastname: Patat
authors.forename: J
authors.initials: J
authors.lastname: Sibilia
authors.forename: H
authors.initials: H
authors.lastname: Petit
authors.forename: J-L
authors.initials: JL
authors.lastname: Cracowski
authors.forename: P
authors.initials: P
authors.lastname: Clerson
authors.forename: M
authors.initials: M
authors.lastname: Humbert
mesh_terms: D000368:Aged; D006328:Cardiac Catheterization; D003971:Diastole; D015150:Echocardiography, Doppler / Q000379:methods; D005260:Female; D005602:France; D006331:Heart Diseases / Q000150:complications / Q000000981:diagnostic imaging*; D006801:Humans; D006976:Hypertension, Pulmonary / Q000150:complications / Q000000981:diagnostic imaging; D017379:Hypertrophy, Left Ventricular / Q000150:complications / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D008944:Mitral Valve Insufficiency / Q000150:complications / Q000000981:diagnostic imaging; D011446:Prospective Studies; D012595:Scleroderma, Systemic / Q000150:complications / Q000000981:diagnostic imaging*; D018487:Ventricular Dysfunction, Left / Q000150:complications / Q000000981:diagnostic imaging