[Effect of hypokalemia on glucose metabolism in primary hyperaldosteronism].
OBJECTIVE
To investigate the effect of potassium deficiency on glucose and insulin metabolism in primary hyperaldosteronism, including aldosterone-producing adenoma (APA) and idiopathic hyperaldosteronism (IHA).


METHODS
Totally 178 patients who were diagnosed as primary hyperaldosteronism (103 patients with APA and 75 with IHA) were divided into hypokalemia group and normal potassium group according to their serum potassium levels. All patients received 3 hours of oral glucose tolerance test and aldosterone test to observe the relationship among glucose, insulin and serum potassium.


RESULTS
Area under curve of serum potassium, area under curve of plasma insulin, and fasting serum insulin were significantly lower in the hypokalemia group than in the normal potassium group (P <0. 05, P <0. 01); area under curve of glucose and aldosterone level were significantly higher in the hypokalemia group than in the normal potassium group ( P < 0. 05 ) . The prevalence of metabolic syndrome was significantly higher in IHA than in APA (57. 3% vs 38. 8% ; P < 0. 05).


CONCLUSIONS
Hypokalemia may play an important role in inhibiting insulin secretion in primary hyperaldosteronism.
Zhang
Jing
J
Department of Endocrinology, PUMC Hospital, CAMS and PUMC, Beijing 100730, China.
Zeng
Zheng-pei
ZP
Zhou
Ya-ru
YR
Tong
An-li
AL
Lu
Lin
L
Song
Ai-ling
AL
Yan
Zhao-li
ZL
Chen
Shi
S
Liang
Wei
W
Li
Yu-xiu
YX
Qin
Shu-wen
SW
D000328:Adult; D001786:Blood Glucose / Q000378:metabolism*; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D006929:Hyperaldosteronism / Q000150:complications / Q000378:metabolism*; D007008:Hypokalemia / Q000150:complications*; D007328:Insulin / Q000378:metabolism*; D008297:Male; D024821:Metabolic Syndrome / Q000209:etiology; D008875:Middle Aged
D001786:Blood Glucose; D007328:Insulin