Increased adenosine deaminase in hydatidiform mole.
BACKGROUND
The aim of the current study was to investigate levels of adenosine deaminase in plasma of patients with hydatidiform mole.


METHODS
Plasma adenosine deaminase levels were determined in 17 women with normal pregnant course, in 17 women with hydatidiform mole, and in 17 non-pregnant healthy volunteers.


RESULTS
Mean adenosine deaminase activity in the hydatidiform mole group was 121.5+/-24.8 U/L, significantly higher than in the pregnant control (7.8+/-6.5 U/L; p<0.0001) and non-pregnant control groups (6.4+/-7.4 U/L; p<0.0001). A cutoff level of 40.5 U/L was found, with both sensitivity and specificity of 100%.


CONCLUSIONS
Adenosine deaminase may play a role in the development of hydatidiform mole.
Engin-Ustün
Yaprak
Y
Department of Obstetrics and Gynecology, School of Medicine, Inonu University, Malatya, Turkey. ustunyaprak@yahoo.com
Ustün
Yusuf
Y
Karabulut
Aysun Bay
AB
Doğan
Keziban
K
Meydanli
M Mutlu
MM
Sezgin
Bülent
B
D000243:Adenosine Deaminase / Q000097:blood*; D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D006828:Hydatidiform Mole / Q000097:blood / Q000201:enzymology*; D011247:Pregnancy; D015854:Up-Regulation
D000243:Adenosine Deaminase