Familial dysphagia and eosinophilia.
BACKGROUND
Recent reports suggest a familial predisposition to eosinophilic esophagitis (EE) and a link between Schatzki's rings and EE.


OBJECTIVE
Our objective is to present our experience with 7 families with dysphagia and eosinophilia.


METHODS
Case series.


METHODS
One-thousand-bed community-based teaching hospital.


METHODS
Seventeen patients from 7 families with dysphagia and eosinophilia.


METHODS
Direct clinical and endoscopic examination with review of radiologic and pathologic data.


RESULTS
Twelve patients had EE alone, one had eosinophilic gastroenteritis (EG) alone, one had EE and EG, and 3 geriatric patients had Schatzki's rings (one with EG and peripheral eosinophilia [PE] and one with PE). EE spanned 2 generations in 4 families and involved 2 brothers in one family.


CONCLUSIONS
This was a case series.


CONCLUSIONS
We propose a familial dysphagia syndrome characterized by eosinophilia in the form of EE, EG, or PE and Schatzki's rings in older generations.
Zink
David A
DA
Division of Gastroenterology and Hepatology, William Beaumont Hospital, Royal Oak, Michigan 48073, USA.
Amin
Mitual
M
Gebara
Souheil
S
Desai
Tusar K
TK
D000293:Adolescent; D000328:Adult; D000369:Aged, 80 and over; D001037:Aphasia / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D004802:Eosinophilia / Q000150:complications* / Q000235:genetics; D004941:Esophagitis / Q000150:complications* / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D013577:Syndrome