Complete congenital anterior pituitary insufficiency and syndrome of inapropriate antidiuretic hormone secretion: a rare association in children.
Two children with complete congenital anterior hypopituitarism developed hyponatremia; inappropriate secretion of antidiuretic hormone was documented despite adequate hormonal replacement therapy. These cases show that congenital hypopituitarism can be associated with SIADH in children later than the neonatal period, despite adequate replacement therapy.
Alharbi
Mohammed
M
Pediatric Endocrinology Unit, Hôpital Necker Enfants-Malades, Paris, France.
Polak
Michel
M
D000293:Adolescent; D002675:Child, Preschool; D005260:Female; D005440:Fluid Therapy; D020249:Hormone Replacement Therapy; D006801:Humans; D007010:Hyponatremia / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D007018:Hypopituitarism / Q000150:complications / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology*; D007177:Inappropriate ADH Syndrome / Q000209:etiology / Q000378:metabolism / Q000473:pathology* / Q000628:therapy; D008279:Magnetic Resonance Imaging; D008297:Male; D010903:Pituitary Gland, Anterior / Q000378:metabolism / Q000473:pathology*; D016896:Treatment Outcome; D014667:Vasopressins / Q000378:metabolism*
D014667:Vasopressins