Long-lasting changes of albino rats behavior and brain bioamines content after immunization against cholecystokinin-3 and -4.
Active immunization against cholecystokinin fragments 31-33 (CCK-3) and 30-33 (CCK-4) results in long-lasting changes of albino rats' behavior. CCK-3 and CCK-4 covalently linked to antigen-carrier evokes the suppression of the anxiety, decreases some signs of depression-like behavior and changes the level of bioamines and their catabolites in striatum at least for two months after immunization. These data can provide a perspective approach to the problem of long term correction of behavior.
Ashmarin
Igor Petrovich
IP
Department of Human Physiology, School of Biology, Moscow State University, Vorobiovy Gory, Moscow, Russia.
Danilova
Raisa A
RA
Obukhova
Maria F
MF
Rud'ko
Olga Igorevna
OI
Andreeva
Ludmila A
LA
D000818:Animals; D001007:Anxiety / Q000276:immunology*; D001679:Biogenic Amines / Q000378:metabolism*; D001921:Brain / Q000378:metabolism*; D002766:Cholecystokinin / Q000276:immunology*; D003342:Corpus Striatum / Q000276:immunology / Q000378:metabolism; D007114:Immunization; D008297:Male; D009842:Oligopeptides / Q000276:immunology*; D051381:Rats; D017208:Rats, Wistar; D012149:Restraint, Physical; D013315:Stress, Psychological / Q000276:immunology; D013550:Swimming; D013758:Tetragastrin / Q000276:immunology*
D001679:Biogenic Amines; D009842:Oligopeptides; D013758:Tetragastrin; D002766:Cholecystokinin