Iron and copper toxicity in diseases of aging, particularly atherosclerosis and Alzheimer's disease.
In this review, we point out that natural selection does not act to lessen human diseases after the reproductive and caregiving period and that normal levels of iron and copper that may be healthy during the reproductive years appear to be contributing to diseases of aging and possibly the aging process itself. It is clear that oxidant damage contributes to many of the diseases of aging, such as atherosclerosis, Alzheimer's disease, Parkinson's diseases, diabetes, diseases of inflammation, diseases of fibrosis, diseases of autoimmunity, and so on. It is equally clear that both iron and copper can contribute to excess production of damaging reactive oxygen species through Fenton chemistry. Here, we examine the evidence that "normal" levels of iron and copper contribute to various diseases of aging.
Brewer
George J
GJ
Department of Human Genetics, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan USA. brewergj@umich.edu
D000375:Aging / Q000473:pathology*; D000544:Alzheimer Disease / Q000473:pathology*; D050197:Atherosclerosis / Q000473:pathology*; D003300:Copper / Q000633:toxicity*; D006801:Humans; D007501:Iron / Q000633:toxicity*
D003300:Copper; D007501:Iron