title: Hippocampal 1H-MRSI correlates with severity of depression symptoms in temporal lobe epilepsy.
abstract: OBJECTIVE
  To investigate the association of an indicator of hippocampal function with severity of depression symptoms in temporal lobe epilepsy.
  
  
  METHODS
  We evaluated 31 patients with video/EEG-confirmed temporal lobe epilepsy using creatine/N-acetylaspartate ratio maps derived from a previously validated (1)H magnetic resonance spectroscopic imaging ((1)H-MRSI) technique at 4.1 T. We also assessed depression symptoms, epilepsy-related factors, and self-perceived social and vocational disability. We used conservative nonparametric bivariate procedures to determine the correlation of severity of depression symptoms with imaging and clinical variables.
  
  
  RESULTS
  The extent of hippocampal (1)H-MRSI abnormalities correlated with severity of depression (Spearman rho = 0.65, p value < 0.001), but other clinical factors did not.
  
  
  CONCLUSIONS
  The extent of hippocampal dysfunction is associated with depression symptoms in temporal lobe epilepsy and may be a more important factor than seizure frequency or degree of disability.
authors.affiliation: The Neurological Institute, Department of Neurology, Columbia University, New York, NY 10032, USA. fgilliam@neruo.columbia.edu
authors.forename: F G
authors.initials: FG
authors.lastname: Gilliam
authors.forename: B M
authors.initials: BM
authors.lastname: Maton
authors.forename: R C
authors.initials: RC
authors.lastname: Martin
authors.forename: S M
authors.initials: SM
authors.lastname: Sawrie
authors.forename: R E
authors.initials: RE
authors.lastname: Faught
authors.forename: J W
authors.initials: JW
authors.lastname: Hugg
authors.forename: M
authors.initials: M
authors.lastname: Viikinsalo
authors.forename: R I
authors.initials: RI
authors.lastname: Kuzniecky
mesh_terms: D000328:Adult; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000032:analysis; D015415:Biomarkers / Q000032:analysis; D003401:Creatine / Q000032:analysis*; D003863:Depression / Q000175:diagnosis* / Q000209:etiology / Q000378:metabolism*; D004833:Epilepsy, Temporal Lobe / Q000150:complications / Q000175:diagnosis* / Q000378:metabolism*; D005260:Female; D006624:Hippocampus / Q000378:metabolism*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008297:Male; D011522:Protons; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013223:Statistics as Topic
chemical_list: D015415:Biomarkers; D011522:Protons; D001224:Aspartic Acid; C000179:N-acetylaspartate; D003401:Creatine