title: Successful treatment of vulvar lichen sclerosus in a child with low-concentration topical tacrolimus ointment.
abstract: Lichen sclerosus is a chronic inflammatory skin disorder that has a predilection for the anogenital area. Topical corticosteroid is occasionally effective; however, continuous treatment is often required and recurrence after its stoppage is frequent. Herein, we report a case of vulvar lichen sclerosus in a 5-year-old girl, which was refractory to topical corticosteroids. After 14 weeks of treatment with 0.03% tacrolimus ointment once daily, the lesions completely resolved without side-effects. Of interest, the number of milia within the plaque of lichen sclerosus was reduced in tandem with the improvement of lichen sclerosus. This is the first report of topical low-concentration tacrolimus treatment showing a dramatic effect in the treatment of childhood vulvar lichen sclerosus.
authors.affiliation: Department of Dermatology, Tokyo Medical University, Tokyo, Japan.
authors.forename: Yuka
authors.initials: Y
authors.lastname: Matsumoto
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Yamamoto
authors.forename: Tamaki
authors.initials: T
authors.lastname: Isobe
authors.forename: Toshio
authors.initials: T
authors.lastname: Kusunoki
authors.forename: Ryoji
authors.initials: R
authors.lastname: Tsuboi
mesh_terms: D000287:Administration, Topical; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage*; D009824:Ointments; D016559:Tacrolimus / Q000008:administration & dosage*; D007724:Vulvar Lichen Sclerosus / Q000188:drug therapy* / Q000473:pathology
chemical_list: D007166:Immunosuppressive Agents; D009824:Ointments; D016559:Tacrolimus