Efficacy of autologous peripheral blood stem cell transplantation in POEMS syndrome with polyneuropathy.
POEMS syndrome (POEMS) is a rare multi-system disease which is typically associated with polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy and skin changes. We report herein a case of POEMS with progressive polyneuropathy resistant to high-dose intravenous immunoglobulin therapy who experienced improvement in polyneuropathy after the administration of high-dose chemotherapy followed by autologous peripheral blood stem cell transplantation. Improvements in polyneuropathy remain despite recognition of monoclonal gammopathy by immunofixation as of 1 year after treatment. We demonstrated that autologous peripheral blood stem cell transplantation can improve clinical symptoms and signs due to polyneuropathy in POEMS even without achieving complete remission.
Imai
Noboru
N
The Department of Neurology, Shizuoka Red Cross Hospital. nboimai@ac.mbn.or.jp
Kitamura
Eiji
E
Tachibana
Takayoshi
T
Konishi
Takashi
T
Suzuki
Youji
Y
Serizawa
Masahiro
M
Okabe
Takashi
T
Fujita
Hiroyuki
H
D003520:Cyclophosphamide / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008875:Middle Aged; D016878:POEMS Syndrome / Q000628:therapy*; D036102:Peripheral Blood Stem Cell Transplantation; D016896:Treatment Outcome
D007166:Immunosuppressive Agents; D003520:Cyclophosphamide