Asymmetric inheritance of mother versus daughter centrosome in stem cell division.
Adult stem cells often divide asymmetrically to produce one self-renewed stem cell and one differentiating cell, thus maintaining both populations. The asymmetric outcome of stem cell divisions can be specified by an oriented spindle and local self-renewal signals from the stem cell niche. Here we show that developmentally programmed asymmetric behavior and inheritance of mother and daughter centrosomes underlies the stereotyped spindle orientation and asymmetric outcome of stem cell divisions in the Drosophila male germ line. The mother centrosome remains anchored near the niche while the daughter centrosome migrates to the opposite side of the cell before spindle formation.
Yamashita
Yukiko M
YM
Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305-5329, USA. yukikomy@umich.edu
Mahowald
Anthony P
AP
Perlin
Julie R
JR
Fuller
Margaret T
MT
D022005:Adherens Junctions / Q000648:ultrastructure; D000818:Animals; D002148:Calmodulin-Binding Proteins; D002454:Cell Differentiation; D002455:Cell Division; D002502:Centrioles / Q000502:physiology; D018385:Centrosome / Q000502:physiology* / Q000648:ultrastructure; D029721:Drosophila Proteins / Q000032:analysis / Q000235:genetics; D004331:Drosophila melanogaster; D005854:Germ Cells / Q000166:cytology* / Q000502:physiology; D007399:Interphase; D008297:Male; D008870:Microtubules / Q000502:physiology / Q000648:ultrastructure; D011993:Recombinant Fusion Proteins / Q000032:analysis; D008941:Spindle Apparatus / Q000502:physiology; D013234:Stem Cells / Q000166:cytology* / Q000502:physiology
D002148:Calmodulin-Binding Proteins; D029721:Drosophila Proteins; C483309:Plp protein, Drosophila; D011993:Recombinant Fusion Proteins