title: [Effect of hypokalemia on glucose metabolism in primary hyperaldosteronism].
abstract: OBJECTIVE
  To investigate the effect of potassium deficiency on glucose and insulin metabolism in primary hyperaldosteronism, including aldosterone-producing adenoma (APA) and idiopathic hyperaldosteronism (IHA).
  
  
  METHODS
  Totally 178 patients who were diagnosed as primary hyperaldosteronism (103 patients with APA and 75 with IHA) were divided into hypokalemia group and normal potassium group according to their serum potassium levels. All patients received 3 hours of oral glucose tolerance test and aldosterone test to observe the relationship among glucose, insulin and serum potassium.
  
  
  RESULTS
  Area under curve of serum potassium, area under curve of plasma insulin, and fasting serum insulin were significantly lower in the hypokalemia group than in the normal potassium group (P <0. 05, P <0. 01); area under curve of glucose and aldosterone level were significantly higher in the hypokalemia group than in the normal potassium group ( P < 0. 05 ) . The prevalence of metabolic syndrome was significantly higher in IHA than in APA (57. 3% vs 38. 8% ; P < 0. 05).
  
  
  CONCLUSIONS
  Hypokalemia may play an important role in inhibiting insulin secretion in primary hyperaldosteronism.
authors.affiliation: Department of Endocrinology, PUMC Hospital, CAMS and PUMC, Beijing 100730, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.forename: Zheng-pei
authors.initials: ZP
authors.lastname: Zeng
authors.forename: Ya-ru
authors.initials: YR
authors.lastname: Zhou
authors.forename: An-li
authors.initials: AL
authors.lastname: Tong
authors.forename: Lin
authors.initials: L
authors.lastname: Lu
authors.forename: Ai-ling
authors.initials: AL
authors.lastname: Song
authors.forename: Zhao-li
authors.initials: ZL
authors.lastname: Yan
authors.forename: Shi
authors.initials: S
authors.lastname: Chen
authors.forename: Wei
authors.initials: W
authors.lastname: Liang
authors.forename: Yu-xiu
authors.initials: YX
authors.lastname: Li
authors.forename: Shu-wen
authors.initials: SW
authors.lastname: Qin
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism*; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D006929:Hyperaldosteronism / Q000150:complications / Q000378:metabolism*; D007008:Hypokalemia / Q000150:complications*; D007328:Insulin / Q000378:metabolism*; D008297:Male; D024821:Metabolic Syndrome / Q000209:etiology; D008875:Middle Aged
chemical_list: D001786:Blood Glucose; D007328:Insulin