title: Environmental factors related to gastric cancer associated with Epstein-Barr virus in Colombia.
abstract: Epstein-Barr virus (EBV)-encoded small RNA can be detected in about 1-17 % of gastric carcinomas. To elucidate lifestyles and other factors related to such an EBV-associated gastric carcinoma (EBV-GC), we conducted a case-control study in Cali, Colombia. The study subjects were 368 patients with gastric carcinoma newly diagnosed during the period between September 2000 and June 2003, including 42 EBV-GC cases. We obtained information on lifestyles, dietary habits, and occupational exposure by a questionnaire. The frequency of EBV-GC was related to birth order of patients (P for trend =0.025). More precisely, EBV-GC was much less frequent among the patients who were the eldest child in a family (P=0.007). Those findings were contrary to what was reported by the study conducted in Japan, where EBV-GC was more frequently observed among eldest brothers/sisters. A possible explanation for the apparently conflicting results is that EBV-GC risk is related to the age at first EBV infection but its relationship is not monotonic. In addition to the relationship with birth order, the present study showed that high salt intake and metal dust exposure may be related to EBV-GC as reported by the Japanese study although these associations observed in the present study were not statistically significant. No significant association was observed in other factors, including dietary habits. Further studies seem warranted to elucidate the difference between Japan and Colombia with respect to the environmental factors related to EBV-GC cases.
authors.affiliation: Department of Epidemiology and Preventive Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
authors.forename: Francia Ivonne
authors.initials: FI
authors.lastname: Campos
authors.forename: Chihaya
authors.initials: C
authors.lastname: Koriyama
authors.forename: Suminori
authors.initials: S
authors.lastname: Akiba
authors.forename: Gabriel
authors.initials: G
authors.lastname: Carrasquilla
authors.forename: Mauricio
authors.initials: M
authors.lastname: Serra
authors.forename: Edwin
authors.initials: E
authors.lastname: Carrascal
authors.forename: Tetsuhiko
authors.initials: T
authors.lastname: Itoh
authors.forename: Yoshie
authors.initials: Y
authors.lastname: Minakami
authors.forename: Yoshito
authors.initials: Y
authors.lastname: Eizuru
mesh_terms: D000368:Aged; D001722:Birth Order; D016022:Case-Control Studies; D003105:Colombia / Q000453:epidemiology; D004032:Diet; D020031:Epstein-Barr Virus Infections / Q000150:complications* / Q000453:epidemiology; D005260:Female; D004854:Herpesvirus 4, Human / Q000302:isolation & purification*; D006801:Humans; D008019:Life Style; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000453:epidemiology / Q000821:virology*; D011795:Surveys and Questionnaires