Total and intraabdominal fat distribution in preadolescents and adolescents: measurement with MR imaging.
OBJECTIVE
To prospectively correlate single- and multisection magnetic resonance (MR) imaging measurements with clinical measurements for assessment of abdominal adipose tissue volumes in healthy (control subjects), overweight, and diabetic overweight preadolescents and adolescents.


METHODS
The study was approved by the institutional internal review board and was HIPAA compliant. Informed consent was obtained from parents, and assent was obtained from control subjects and patients. Thirty total study subjects (20 male, 10 female; age range, 10-18 years; mean, 14.5 years) underwent MR imaging, anthropometric measurement, and dual x-ray absorptiometry (DXA). A computer-assisted software program was used to quantify subcutaneous, visceral, and total abdominal adipose tissue volumes. Single-section measurements at disk space L4-L5 and whole-abdominal multisection measurements were compared, and each method was tested for correlations with anthropometric and DXA measurements with Spearman rho and Pearson correlation (r) coefficients. Single- and multisection image analyses required 5 and 25 minutes per subject, respectively.


RESULTS
There was a high degree of correlation between single- and multisection MR imaging methods for measurement of subcutaneous (r = 0.97), visceral (r = 0.96), and total abdominal fat (r = 0.97). MR imaging fat measurements strongly correlated with anthropometric measurements (rho correlation range, 0.81-0.96; P <or= .02), with overlapping 95% confidence intervals (CIs) for single- and multisection MR imaging correlations. MR imaging percentage of intraabdominal fat measurements (mean, 23%; 95% CI: 17%, 29%) highly correlated with DXA abdominal fat measurements (mean, 26%; 95% CI: 21%, 31%). Significant differences were found among healthy subjects, overweight patients, and diabetic overweight patients for total fat volumes (P < .001) but not for fat distribution patterns.


CONCLUSIONS
Single- and multisection MR imaging measurements for the quantitative assessment of abdominal adipose tissue strongly correlate with clinical and DXA fat measurements.
Siegel
Marilyn J
MJ
Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 S Kingshighway Blvd, St Louis, MO 63110, USA. siegelm@mir.wustl.edu
Hildebolt
Charles F
CF
Bae
Kyongtae T
KT
Hong
Cheng
C
White
Neil H
NH
D000005:Abdomen / Q000473:pathology*; D000273:Adipose Tissue / Q000473:pathology*; D000293:Adolescent; D050218:Body Fat Distribution / Q000379:methods*; D002648:Child; D048909:Diabetes Complications / Q000473:pathology*; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D009765:Obesity / Q000150:complications / Q000473:pathology*