Dietary intake of folate and co-factors in folate metabolism, MTHFR polymorphisms, and reduced rectal cancer.
Little is known about the contribution of polymorphisms in the methylenetetrahydrofolate reductase gene (MTHFR) and the folate metabolism pathway in rectal cancer alone. Data were from participants in a case-control study conducted in Northern California and Utah (751 cases and 979 controls). We examined independent associations and interactions of folate, B vitamins, methionine, alcohol, and MTHFR polymorphisms (MTHFR C677T and A1298C) with rectal cancer. Dietary folate intake was associated with a reduction in rectal cancer OR 0.66, 95% CI 0.48-0.92 (>475 mcg day compared to < or = 322 mcg) as was a combination of nutrient intakes contributing to higher methyl donor status (OR 0.79, 95% CI 0.66-0.95). Risk was reduced among women with the 677 TT genotype (OR 0.54, 95% CI 0.30-0.9), but not men (OR 1.11, 95% CI 0.70-1.76) and with the 1298 CC genotype in combined gender analysis (OR 0.67, 95% CI 0.46-0.98). These data are consistent with a protective effect of increasing dietary folate against rectal cancer and suggest a protective role of the MTHFR 677 TT genotype in women and 1298 CC in men and women. Folate intake, low methyl donor status, and MTHFR polymorphisms may play independent roles in the etiology of rectal cancer.
Murtaugh
Maureen A
MA
Health Research Center, University of Utah, Salt Lake City, UT 84108, USA. mmurtaugh@hrc.utah.edu
Curtin
Karen
K
Sweeney
Carol
C
Wolff
Roger K
RK
Holubkov
Richard
R
Caan
Bette J
BJ
Slattery
Martha L
ML
D000328:Adult; D000368:Aged; D000428:Alcohol Drinking; D002140:California / Q000453:epidemiology; D016022:Case-Control Studies; D004032:Diet; D004034:Diet Surveys; D005260:Female; D005492:Folic Acid / Q000378:metabolism*; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D016015:Logistic Models; D008297:Male; D008715:Methionine / Q000378:metabolism; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D008875:Middle Aged; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012004:Rectal Neoplasms / Q000453:epidemiology* / Q000235:genetics / Q000378:metabolism; D012256:Riboflavin / Q000378:metabolism; D012306:Risk; D014589:Utah / Q000453:epidemiology; D014805:Vitamin B 12 / Q000378:metabolism; D025101:Vitamin B 6 / Q000378:metabolism
D025101:Vitamin B 6; D005492:Folic Acid; D008715:Methionine; D042965:Methylenetetrahydrofolate Reductase (NADPH2); D014805:Vitamin B 12; D012256:Riboflavin