title: Netrin signaling leading to directed growth cone steering.
abstract: In the developing nervous system, nerve cells and axons respond to various attractive and repulsive guidance cues while traveling to their final destination. Netrins are bifunctional guidance cues that attract several classes of axons but repel others. The response of an axon to netrins is dictated by the composition of netrin receptors on the cell surface and the internal state of the growth cone. Recent analyses have identified several signal transduction pathways that contribute to netrin-mediated guidance. A model emerges in which tyrosine phosphorylation, phosphatidylinositol signaling and regulation by Rho GTPases act in concert to trigger extension of axons and turning of growth cones in response to Netrin1.
authors.affiliation: Department of Molecular, Cellular and Developmental Biology and Cell Biology, Yale University, 219 Prospect Street, Kline Biology Tower-232, New Haven, CT 06520, USA.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Round
authors.forename: Elke
authors.initials: E
authors.lastname: Stein
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D020439:Growth Cones / Q000378:metabolism* / Q000648:ultrastructure; D006801:Humans; D009414:Nerve Growth Factors / Q000378:metabolism*; D009420:Nervous System / Q000196:embryology* / Q000378:metabolism*; D000075386:Netrin Receptors; D000075388:Netrin-1; D010716:Phosphatidylinositols / Q000378:metabolism; D011505:Protein-Tyrosine Kinases / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*; D025521:Tumor Suppressor Proteins / Q000378:metabolism*; D020741:rho GTP-Binding Proteins / Q000378:metabolism
chemical_list: C000617351:NTN1 protein, human; D009414:Nerve Growth Factors; D000075386:Netrin Receptors; D010716:Phosphatidylinositols; D011956:Receptors, Cell Surface; D025521:Tumor Suppressor Proteins; D000075388:Netrin-1; D011505:Protein-Tyrosine Kinases; D020741:rho GTP-Binding Proteins