Matrix metalloproteinases and proteoglycans in axonal regeneration.
After an injury to the adult mammalian central nervous system (CNS), a variety of growth-inhibitory molecules are upregulated. A glial scar forms at the site of injury and is composed of numerous molecular substances, including chondroitin sulfate proteoglycans (CSPGs). These proteoglycans inhibit axonal growth in vitro and in vivo. Matrix metalloproteinases (MMPs) can degrade the core protein of some CSPGs as well as other growth-inhibitory molecules such as Nogo and tenascin-C. MMPs have been shown to facilitate axonal regeneration in the adult mammalian peripheral nervous system (PNS). This review will focus on the various roles of proteoglycans and MMPs within the injured nervous system. First, we will present a general background on the injured central nervous system and explore the roles that proteoglycans play in the injured PNS and CNS. Second, we will discuss the various functions of MMPs within the injured PNS and CNS. Special attention will be paid to the possibility of how MMPs might modify the growth-inhibitory extracellular environment of the injured adult mammalian spinal cord and facilitate axonal regeneration in the CNS.
Pizzi
Michael A
MA
Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Zablocki VAMC, 5000 West National Avenue, Milwaukee, WI 53295, USA.
Crowe
Maria J
MJ
D000818:Animals; D001369:Axons / Q000473:pathology*; D002493:Central Nervous System Diseases / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D020782:Matrix Metalloproteinases / Q000378:metabolism*; D009416:Nerve Regeneration / Q000502:physiology*; D011509:Proteoglycans / Q000378:metabolism*
D011509:Proteoglycans; D020782:Matrix Metalloproteinases