Changes in pelvic and systemic platinum concentrations during negative-balance isolated pelvic perfusion: correlation between platinum concentration and method of administration in a pig model.
OBJECTIVE
To assess the effect of altering the method of administration during negative-balance isolated pelvic perfusion (NIPP) on the platinum concentration in the pelvic or systemic circulation.


METHODS
Twenty female pigs were used in this study. The abdominal aorta and the infra-renal vena cava were occluded with two balloon catheters and blood in the extracorporeal circuit was circulated with twin rotary pumps. NIPP was then performed with cisplatin (5 mg/kg) in 15 pigs. Three types of NIPP administration method (group A: 1 bolus, B: 2 same doses boluses, C: 3 same doses boluses) were used, five pigs being subjected to each treatment. The remaining five pigs were administered cisplatin systemically as a control study (group D). The platinum concentrations in the pelvic and systemic circulation were measured and compared.


RESULTS
(1) Pelvic circulation: There was a tendency for the platinum concentration to increase as the bolus time decreased. The platinum concentration in groups A and B was significantly (P < 0.05) higher than that in group C. Significant differences (P < 0.05) between groups A and B until 10 min after the start of NIPP. (2) Systemic circulation: Significant differences (P < 0.05) were observed between NIPP groups and D during NIPP. The platinum concentration in group D was five times higher than that in group C. (3) Plasma pelvic to systemic exposure ratio: there were no significant differences among the three NIPP groups.


CONCLUSIONS
The platinum concentrations in the pelvic and systemic circulation increased as the bolus time decreased. The plasma pelvic to systemic exposure ratio was not influenced by bolus time.
Murata
Satoru
S
Department of Radiology, Center for Advanced Medical Technology, Nippon Medical School, 1-1-5 Sendagi, Tokyo 113-8602, Japan. genji@nms.ac.jp
Tajima
Hiroyuki
H
Abe
Yutaka
Y
Onozawa
Shiro
S
Uchiyama
Fumio
F
Hayashi
Hiromitsu
H
Kimata
Ryoji
R
Nomura
Kazuhiro
K
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage; D010478:Chemotherapy, Cancer, Regional Perfusion / Q000379:methods*; D002945:Cisplatin / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D005260:Female; D010388:Pelvis / Q000098:blood supply*; D010477:Perfusion; D010984:Platinum / Q000097:blood*; D013552:Swine
D000970:Antineoplastic Agents; D010984:Platinum; D002945:Cisplatin