A genome-wide linkage scan for 25-OH-D(3) and 1,25-(OH)2-D3 serum levels in asthma families.
To identify genome regions linked to serum vitamin D metabolites we analyzed 25-OH-D(3) and 1,25-(OH)(2)-D(3) levels from 947 participants of a family study recruited for asthma. From these individuals data were available from a previous genome scan that included 364 autosomal microsatellite marker. 25-OH-D(3) levels showed a heritability of 80% in these families while 1,25-(OH)(2)-D(3) reached only 30%. Genome-wide linkage using variance component analysis showed increased LOD scores for 25-OH-D(3) at marker D1S2815 (unadjusted LOD 2.9), D2S2153 (LOD 3.4), D5S2017 (LOD 2.5), D6S260 (LOD 2.1) and D17S1824 (2.5). In contrast, the maximum LOD score for 1,25-(OH)(2)-D(3) level was only 1.2 at marker D17S926. We conclude that only 25-OH-D(3) serum levels are under genetic control where several genes are involved. The lead linkage region does not code for enzymes already known in the metabolic pathway of vitamin D and may therefore contain further genes relevant to the regulation of vitamin D serum levels.
Wjst
Matthias
M
Institut für Epidemiologie, Gruppe Molekulare Epidemiologie, GSF, Forschungszentrum für Umwelt und Gesundheit, Ingolstädter Landstrasse 1, Neuherberg, Munich, Germany. m@wjst.de
Altmüller
Janine
J
Braig
Christine
C
Bahnweg
Margret
M
André
Elisabeth
E
D001249:Asthma / Q000097:blood* / Q000235:genetics* / Q000473:pathology; D002112:Calcifediol / Q000097:blood*; D004100:Dihydroxycholecalciferols / Q000097:blood*; D008040:Genetic Linkage / Q000235:genetics*; D015894:Genome, Human / Q000235:genetics*; D006801:Humans; D010375:Pedigree
D004100:Dihydroxycholecalciferols; D002112:Calcifediol