Metabolites from the Lichen Ochrolechia parella growing under two different heliotropic conditions.
A new chloro-depsidone (1) and five known compounds, variolaric acid (2), lecanoric acid (3), alpha-alectoronic acid (4), atranorin (5), and ergosterol peroxide (6), have been isolated from the lichen Ochrolechia parella. The structure of compound 1 was elucidated by spectroscopic analysis. Additionally, the tautomeric equilibrium of compound 4 was investigated. In the present study, two specimens of this lichen, growing under different light conditions, were analyzed. The major compound in both samples was found to be 2, but the amount of this metabolite was significantly higher in the shaded specimen (0.76% w/w). The new compound parellin (1) predominated in the specimen grown under shady conditions, while atranorin (5) was found only in the sunlit specimen. The cytotoxic activities of 2, 4, and 6 against B16 melanoma cells were evaluated.
Millot
Marion
M
Institut de Chimie de Rennes, EA 4090 Substances Lichéniques et Photoprotection, Faculté de Pharmacie, 2 Avenue du Professeur Léon Bernard, 35043 Rennes Cedex, France.
Tomasi
Sophie
S
Articus
Kristina
K
Rouaud
Isabelle
I
Bernard
Aurélie
A
Boustie
Joël
J
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D053630:Depsides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005602:France; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008011:Lichens / Q000737:chemistry*; D015394:Molecular Structure
D000972:Antineoplastic Agents, Phytogenic; D053630:Depsides; D007783:Lactones; C518563:parellin; C000875:depsidone