title: A checklist for medication compliance and persistence studies using retrospective databases.
abstract: The increasing number of retrospective database studies related to medication compliance and persistence (C&P), and the inherent variability within each, has created a need for improvement in the quality and consistency of medication C&P research. This article stems from the International Society of Pharmacoeconomics and Outcomes Research (ISPOR) efforts to develop a checklist of items that should be either included, or at least considered, when a retrospective database analysis of medication compliance or persistence is undertaken. This consensus document outlines a systematic approach to designing or reviewing retrospective database studies of medication C&P. Included in this article are discussions on data sources, measures of C&P, results reporting, and even conflict of interests. If followed, this checklist should improve the consistency and quality of C&P analyses, which in turn will help providers and payers understand the impact of C&P on health outcomes.
authors.affiliation: Department of Pharmacy Practice/Pharmacy Administration, Philadelphia College of Pharmacy, University of the Sciences in Philadelphia, 600 South 43rd Street, Philadelphia, PA 19104, USA. a.peters@usip.edu
authors.forename: Andrew M
authors.initials: AM
authors.lastname: Peterson
authors.forename: David P
authors.initials: DP
authors.lastname: Nau
authors.forename: Joyce A
authors.initials: JA
authors.lastname: Cramer
authors.forename: Josh
authors.initials: J
authors.lastname: Benner
authors.forename: Femida
authors.initials: F
authors.lastname: Gwadry-Sridhar
authors.forename: Michael
authors.initials: M
authors.lastname: Nichol
mesh_terms: D016206:Databases, Bibliographic / Q000592:standards*; D004358:Drug Therapy; D017408:Guidelines as Topic; D006801:Humans; D007390:International Agencies; D010349:Patient Compliance; D012107:Research Design; D012189:Retrospective Studies; D012957:Societies, Pharmaceutical; D014481:United States