Fulminant amoebic colitis following loperamide use.
Toxic megacolon is a rare consequence of infection with Entamoeba histolytica. We present such a patient in whom the course of disease may have been influenced by heavy loperamide use. Loperamide and other anti-motility agents have been implicated previously in the pathogenesis of toxic megacolon in patients with infectious gastroenteritis.
McGregor
Alastair
A
Hospital for Tropical Diseases, University College London Hospitals NHS Trust, London, UK.
Brown
Michael
M
Thway
Khin
K
Wright
Stephen G
SG
D000818:Animals; D000930:Antidiarrheals / Q000008:administration & dosage* / Q000009:adverse effects; D003082:Colectomy; D003937:Diagnosis, Differential; D003967:Diarrhea / Q000188:drug therapy* / Q000473:pathology; D004404:Dysentery, Amebic / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D004748:Entamoeba histolytica / Q000302:isolation & purification*; D005260:Female; D006801:Humans; D008139:Loperamide / Q000008:administration & dosage* / Q000009:adverse effects; D008875:Middle Aged; D012720:Severity of Illness Index; D014195:Travel
D000930:Antidiarrheals; D008139:Loperamide