Lessons from Leptin's molecular biology: Potential therapeutic actions of recombinant leptin and leptin-related compounds.
Leptin, a peptide secreted by the white adipose tissue, circulates to the central nervous system and signals the status of body energy stores, regulating feeding behavior and energy balance. As human obesity is characterized by hyperleptinemia and leptin resistance, increasing leptin sensitivity is an attractive target for obesity treatment.
Correia
M L G
ML
General Clinical Research Center, Department of Internal Medicine-157 MRF, University of Iowa, Iowa City, IA, 52242, USA. marcelo-correia@uiowa.edu
Haynes
W G
WG
D006801:Humans; D020738:Leptin / Q000235:genetics / Q000502:physiology* / Q000627:therapeutic use; D050356:Lipid Metabolism; D009765:Obesity / Q000188:drug therapy / Q000503:physiopathology; D011994:Recombinant Proteins / Q000235:genetics / Q000378:metabolism / Q000627:therapeutic use; D015398:Signal Transduction
D020738:Leptin; D011994:Recombinant Proteins