Recent advances in the development of agonists selective for beta1-type thyroid hormone receptor.
This mini-review will provide an overview on the recent design principles and structure-activity-relationship of beta-selective thyroid hormone receptor (TR) agonists. The prospects for the treatment of metabolic diseases as dyslipidemia with TRbeta-selective ligands are considerable enough so as to avoid cardiovascular acceleration mediated through TRalpha.
Malm
J
J
Karo Bio AB, Novum, S-141 57, Sweden. johan.malm@karobio.se
Grover
G J
GJ
Färnegårdh
M
M
D006801:Humans; D008958:Models, Molecular; D011487:Protein Conformation; D013329:Structure-Activity Relationship; D037042:Thyroid Hormone Receptors beta / Q000819:agonists* / Q000737:chemistry
D037042:Thyroid Hormone Receptors beta