title: Electrically evoked auditory steady-state responses in Guinea pigs.
abstract: Most cochlear implant systems available today provide the user with information about the envelope of the speech signal. The goal of this study was to explore the feasibility of recording electrically evoked auditory steady-state response (ESSR) and in particular to evaluate the degree to which the response recorded using electrical stimulation could be separated from stimulus artifact. Sinusoidally amplitude-modulated electrical stimuli with alternating polarities were used to elicit the response in adult guinea pigs. Separation of the stimulus artifact from evoked neural responses was achieved by summing alternating polarity responses or by using spectral analysis techniques. The recorded response exhibited physiological response properties including a pattern of nonlinear growth and their abolishment following euthanasia or administration of tetrodotoxin. These findings demonstrate that the ESSR is a response generated by the auditory system and can be separated from electrical stimulus artifact. As it is evoked by a stimulus that shares important features of cochlear implant stimulation, this evoked potential may be useful in either clinical or basic research efforts.
authors.affiliation: Department of Speech Pathology and Audiology, Department of Otolaryngology--HNS, University of Iowa, Iowa City, Iowa, USA. jeng@ohio.edu
authors.forename: Fuh-Cherng
authors.initials: FC
authors.lastname: Jeng
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Abbas
authors.forename: Carolyn J
authors.initials: CJ
authors.lastname: Brown
authors.forename: Charles A
authors.initials: CA
authors.lastname: Miller
authors.forename: Kirill V
authors.initials: KV
authors.lastname: Nourski
authors.forename: Barbara K
authors.initials: BK
authors.lastname: Robinson
mesh_terms: D000161:Acoustic Stimulation / Q000379:methods; D000779:Anesthetics, Local / Q000494:pharmacology; D000818:Animals; D016477:Artifacts; D001307:Auditory Perception / Q000502:physiology*; D003054:Cochlear Implants; D004195:Disease Models, Animal; D004558:Electric Stimulation / Q000379:methods*; D005072:Evoked Potentials, Auditory / Q000187:drug effects / Q000502:physiology*; D006168:Guinea Pigs; D006319:Hearing Loss, Sensorineural / Q000139:chemically induced / Q000503:physiopathology* / Q000628:therapy; D013779:Tetrodotoxin / Q000494:pharmacology
chemical_list: D000779:Anesthetics, Local; D013779:Tetrodotoxin