title: Fine-Tuning Reception in the Bone: PPARgamma and Company.
abstract: PPARgamma plays a central role in the formation of fat. Regulation of PPARgamma activity depends on numerous factors ranging from dietary ligands to nuclear hormone coactivators and corepressors to oxygen-sensing mechanisms. In addition, the interplay of PPARgamma with other nuclear hormone receptors has implications for the balance between adipogenesis and osteogenesis in mesenchymal stem cells of the bone marrow stroma. This review will explore a range of factors influencing PPARgamma activity and how these interactions may affect osteogenesis.
authors.affiliation: Stem Cell Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA.
authors.forename: Z Elizabeth
authors.initials: ZE
authors.lastname: Floyd
authors.forename: Sanjin
authors.initials: S
authors.lastname: Zvonic
authors.forename: Mark
authors.initials: M
authors.lastname: E Nuttall
authors.forename: Jeffrey
authors.initials: J
authors.lastname: M Gimble