title: Solubilization of saponins of Bupleuri radix with ginseng saponins: cooperative effect of dammarane saponins.
abstract: It has been found that the water solubilities of saikosaponins, the active principles of Bupleuri radix, are greatly increased in the presence of ginsenoside-Ro, the glucuronide bisdesmoside of oleanolic acid of Ginseng. No solubilizing effect was observed with the neutral dammarane Saponins of Ginseng. However, the solubilizing effect of ginsenoside-Ro was significantly potentiated in the presence of the dammarane saponins of 20 ( S)-protopanaxadiol. The relationship between the solubilizing effect and the structure of ginsenoside-Ro was also investigated, elucidating the important role of the glucuronide moiety.
authors.affiliation: Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine, Kasumi, Minami-ku, Hiroshima Japan.
authors.forename: K
authors.initials: K
authors.lastname: Watanabe
authors.forename: H
authors.initials: H
authors.lastname: Fujino
authors.forename: T
authors.initials: T
authors.lastname: Morita
authors.forename: R
authors.initials: R
authors.lastname: Kasai
authors.forename: O
authors.initials: O
authors.lastname: Tanaka