A designed RNA shuts down transcription.
Using an in vivo selection strategy, Kehayova and Liu identified an RNA molecule capable of silencing gene transcription in yeast . In doing so, they expand the repertoire of RNA molecules performing long-believed "protein-only" cellular functions.
Weigand
Julia E
JE
Lehrstuhl für Mikrobiologie, Friedrich-Alexander-Universität Erlangen-Nürnberg, Staudtstr. 5, 91058 Erlangen, Germany.
Suess
Beatrix
B
D015195:Drug Design; D020868:Gene Silencing / Q000187:drug effects; D005818:Genetic Engineering; D012313:RNA / Q000737:chemistry / Q000494:pharmacology*; D014158:Transcription, Genetic / Q000187:drug effects*; D015003:Yeasts
D012313:RNA