Raloxifene improves the ovariectomy-induced impairment in endothelium-dependent vasodilation.
OBJECTIVE
To examine the effect of raloxifene on the endothelial dysfunction caused by surgical menopause.


METHODS
Ten premenopausal women who underwent gynecological surgery with ovariectomy were divided into two groups. Five participants used raloxifene (60 mg/d) for 7 days staring 1 week after the surgery, and the other five participants did not use raloxifene. We examined the changes in flow-mediated dilatation (FMD) of the brachial artery using ultrasonography. Vasodilation in response to nitroglycerin was also studied. We also measured the brachial-ankle pulse wave velocity to examine the change in arterial stiffness in these participants before and after surgical menopause.


RESULTS
In both the raloxifene and control groups, a significant decrease in FMD was observed 1 week after the surgery. Although no further changes in FMD were observed in the control group at 2 weeks after surgery, FMD was significantly increased in the raloxifene group. No remarkable changes in nitroglycerin or brachial-ankle pulse wave velocity were observed after surgery in either group.


CONCLUSIONS
Raloxifene rapidly restored FMD that was impaired after surgical menopause. Therefore, raloxifene may be effective for ameliorating and maintaining endothelial function in premenopausal women who undergo ovariectomy.
Takahashi
Kazuhiro
K
Department of Obstetrics and Gynecology, Yamagata University School of Medicine, Iidanishi, Yamagata, Japan. ktaka@med.id.yamagata-u.ac.jp
Mori-Abe
Akiko
A
Takata
Keiko
K
Ohta
Tsuyoshi
T
Kawagoe
Jun
J
Tsutsumi
Seiji
S
Ohmichi
Masahide
M
Kurachi
Hirohisa
H
D000328:Adult; D000842:Ankle / Q000098:blood supply; D001783:Blood Flow Velocity; D001916:Brachial Artery / Q000000981:diagnostic imaging / Q000502:physiology; D004730:Endothelium, Vascular / Q000187:drug effects*; D005260:Female; D019584:Hot Flashes / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D008593:Menopause; D008875:Middle Aged; D010052:Ovariectomy; D011673:Pulsatile Flow; D020849:Raloxifene Hydrochloride / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D020845:Selective Estrogen Receptor Modulators / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D016896:Treatment Outcome; D014463:Ultrasonography; D014664:Vasodilation / Q000187:drug effects*
D020845:Selective Estrogen Receptor Modulators; D020849:Raloxifene Hydrochloride