title: Tea consumption and basal cell and squamous cell skin cancer: results of a case-control study.
abstract: BACKGROUND
  Tea constituents, including polyphenols, are hypothesized to have chemopreventive properties, and inhibit the induction of skin cancers in animal models.
  
  
  OBJECTIVE
  To explore the association between regular tea consumption (>or=1 cup/d for >or=1 month) and the incidence of squamous cell (SCC) and basal cell (BCC) carcinomas.
  
  
  METHODS
  A population-based case-control study of 770 individuals with BCC, 696 with SCC, and 715 age- and sex-matched control subjects.
  
  
  RESULTS
  After adjustment for age, sex, and lifetime history of painful sunburns, ever having consumed tea regularly was associated with a significantly lower risk of SCC (odds ratio [OR] = 0.70; 95% confidence interval [CI] 0.53-0.92), especially among long-term drinkers (>or=47 years consumption: SCC, OR = 0.49; 95% CI 0.29-0.83; P for trend = .008) and among those consuming >or=2 cups/d (OR = 0.65; 95% CI 0.44-0.96; P for trend = 0.013). After adjustment for age and sex, ever having consumed tea regularly was weakly associated with BCC risk (OR = 0.79; 95% CI 0.63-0.98).
  
  
  CONCLUSIONS
  Our case-control study was susceptible to recall bias and to confounding by unknown cancer risk factors associated with tea consumption.
  
  
  CONCLUSIONS
  Our findings support the existence of an inverse association between tea consumption and skin carcinogenesis.
authors.affiliation: Department of Community and Family Medicine (Section of Biostatistics and Epidemiology), Dartmouth Medical School, Lebanon, NH, USA. Judith.R.Rees@dartmouth.edu
authors.forename: Judy R
authors.initials: JR
authors.lastname: Rees
authors.forename: Therese A
authors.initials: TA
authors.lastname: Stukel
authors.forename: Ann E
authors.initials: AE
authors.lastname: Perry
authors.forename: Michael S
authors.initials: MS
authors.lastname: Zens
authors.forename: Steven K
authors.initials: SK
authors.lastname: Spencer
authors.forename: Margaret R
authors.initials: MR
authors.lastname: Karagas
mesh_terms: D000328:Adult; D000368:Aged; D001628:Beverages; D002280:Basal Cell Carcinoma / Q000453:epidemiology*; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology*; D016022:Case-Control Studies; D004326:Drinking; D004327:Drinking Behavior; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012306:Risk; D012878:Skin Neoplasms / Q000235:genetics*; D013662:Tea
chemical_list: D013662:Tea