Antifungal drug susceptibility profile of Pichia anomala isolates from patients presenting with nosocomial fungemia.
In vitro susceptibility of 58 isolates of Pichia anomala to five antifungal drugs using two broth microdilution methods (CLSI and EUCAST) was analyzed. Low susceptibility to itraconazole was observed. Fluconazole, voriconazole, amphotericin B, and caspofungin showed good antifungal activity, although relatively high drug concentrations were necessary to inhibit the isolates.
da Matta
Vânia Lúcia Ribeiro
VL
Instituto Adolfo Lutz, Av Dr. Arnaldo 351, 11 andar, São Paulo, São Paulo, Brazil 01246-901. mattav@usp.br
de Souza Carvalho Melhem
Márcia
M
Colombo
Arnaldo Lopes
AL
Moretti
Maria Luiza
ML
Rodero
Laura
L
Duboc de Almeida
Gisele Madeira
GM
dos Anjos Martins
Marilena
M
Costa
Silvia Figueiredo
SF
Souza Dias
Maria Beatriz G
MB
Nucci
Márcio
M
Levin
Anna S
AS
D000666:Amphotericin B / Q000494:pharmacology; D000935:Antifungal Agents / Q000494:pharmacology*; D003428:Cross Infection / Q000382:microbiology*; D015725:Fluconazole / Q000494:pharmacology; D016469:Fungemia / Q000453:epidemiology / Q000382:microbiology*; D006801:Humans; D017964:Itraconazole / Q000494:pharmacology; D008826:Microbial Sensitivity Tests / Q000379:methods*; D010843:Pichia / Q000187:drug effects* / Q000302:isolation & purification
D000935:Antifungal Agents; D017964:Itraconazole; D000666:Amphotericin B; D015725:Fluconazole