Systemically disseminated extranodal marginal zone B-cell lymphoma of lacrimal gland in a patient with systemic lupus erythematosus.
A 33-year-old woman with systemic lupus erythematosus had bilateral eyelid swelling. On examination, bilateral lacrimal gland mass were palpable. The morphologic and the immunohistochemical features were supportive of the diagnosis of extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue-type (MALT lymphoma). Further systemic evaluation revealed she had clinical stage IV disease with bone marrow involvement. She underwent local radiotherapy and several cycles of chemotherapy. However, the patient died of sepsis with the disease after 48 months. Systemically disseminated MALT lymphoma presenting initially in the lacrimal gland of a patient with systemic lupus erythematosus is rare, and the prognosis is poor.
Lin
Yen-Ching
YC
Department of Ophthalmology, Su-Ao Veterans Hospital, I-Lan, Taiwan, Republic of China.
Kau
Hui-Chuan
HC
Kao
Shu-Ching
SC
Hsu
Wen-Ming
WM
Tsai
Chieh-Chih
CC
D000328:Adult; D019046:Bone Marrow Neoplasms / Q000473:pathology*; D005134:Eye Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007766:Lacrimal Apparatus Diseases / Q000000981:diagnostic imaging / Q000473:pathology*; D008180:Lupus Erythematosus, Systemic / Q000473:pathology*; D018442:Lymphoma, B-Cell, Marginal Zone / Q000000981:diagnostic imaging / Q000473:pathology*; D009367:Neoplasm Staging; D009915:Orbit / Q000000981:diagnostic imaging; D014057:Tomography, X-Ray Computed