title: A facile two-step synthesis of 8-arylated guanosine mono- and triphosphates (8-aryl GXPs).
abstract: We report a simple and high-yielding two-step procedure for the preparation of 8-arylated guanosine mono- and triphosphates (8-aryl GXPs). The key step of our synthesis is the Suzuki-Miyaura coupling of unprotected 8-bromo GMP and 8-bromo GTP with various arylboronic acids in aqueous solution. The 8-bromoguanosine 5'-phosphates required as cross-coupling substrates were prepared from 8-bromoguanosine via an optimised Yoshikawa procedure.
authors.affiliation: Centre for Carbohydrate Chemistry, School of Chemical Sciences and Pharmacy, University of East Anglia, Norwich, UKNR4 7TJ.
authors.forename: Alice
authors.initials: A
authors.lastname: Collier
authors.forename: Gerd
authors.initials: G
authors.lastname: Wagner
mesh_terms: D006151:Guanosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis*; D015394:Molecular Structure
chemical_list: D006151:Guanosine