SGN Sim, a stochastic genetic networks simulator.
We present SGNSim, 'Stochastic Gene Networks Simulator', a tool to model gene regulatory networks (GRN) where transcription and translation are modeled as multiple time delayed events and its dynamics is driven by a stochastic simulation algorithm (SSA) able to deal with multiple time delayed events. The delays can be drawn from several distributions and the reaction rates from complex functions or from physical parameters. SGNSim can generate ensembles of GRNs, within a set of user-defined parameters, such as topology. It can also be used to model specific GRNs and systems of chemical reactions. Perturbations, e.g. gene deletion, over-expression, copy and mutation, can be modeled as well. As examples, we present a model of a toggle switch without cooperative binding subject to perturbations, a system of reactions within a compartmentalized environment where membrane crossing is controlled by a negative feedback mechanism and a simulation based on the yeast transcriptional network.


BACKGROUND
SGNSim program, instructions and examples available at www.ucalgary.ca/~aribeiro/SGNtheSim/SGNtheSim.html.
Ribeiro
Andre S
AS
Institute for Biocomplexity and Informatics, University of Calgary, Canada. ARibeiro@ucalgary.ca
Lloyd-Price
Jason
J
D000465:Algorithms; D003198:Computer Simulation; D005786:Gene Expression Regulation / Q000235:genetics*; D008957:Models, Genetic; D015233:Models, Statistical; D014176:Protein Biosynthesis / Q000235:genetics*; D020543:Proteome / Q000235:genetics*; D015398:Signal Transduction / Q000235:genetics*; D013269:Stochastic Processes; D014158:Transcription, Genetic / Q000235:genetics*
D020543:Proteome