title: Hepatitis C treatment candidacy and outcomes among 4318 US veterans with chronic hepatitis C virus infection: does a history of injection drug use matter?
abstract: OBJECTIVE
  Many patients with a history of injection drug use (IDU) are excluded from hepatitis C virus (HCV) treatment. This prospective multicenter study aimed to determine the impact of IDU history on HCV treatment candidacy and outcomes.
  
  
  METHODS
  Between 1999 and 2001, 4318 HCV-infected patients seen at 24 VA Medical Centers were evaluated for HCV treatment candidacy and followed prospectively. Univariate and multivariate logistic regression analyses were used to determine whether an IDU history was associated with HCV treatment candidacy, HCV treatment acceptance, early treatment discontinuation, and virologic response.
  
  
  RESULTS
  Of 4318 participants, 2611 (61%) reported an IDU history. IDU history was not significantly associated with HCV treatment candidacy, acceptance, early discontinuation of therapy, or virologic response (all P values nonsignificant). Instead, reduced HCV treatment candidacy was independently associated with low-income [odds ratio (OR)=1.46, 95% confidence interval (CI)=1.22-1.74), education < or = 12 years (OR=1.23, 95% CI=1.03-1.46), and alcohol consumption > or = 3 drinks/d (OR=2.08, 95% CI=1.68-2.57), whereas early discontinuation of HCV therapy was independently associated with low-income and consuming > or = 3 alcoholic drinks/d.
  
  
  CONCLUSIONS
  A history of IDU was not associated with HCV treatment candidacy or outcomes, supporting national guidelines to evaluate former IDUs on a case-by-case basis for HCV treatment.
authors.affiliation: VA Medical Center, San Francisco, CA 94121, USA. Karen.Seal@va.gov
authors.forename: Karen H
authors.initials: KH
authors.lastname: Seal
authors.forename: Sue L
authors.initials: SL
authors.lastname: Currie
authors.forename: Hui
authors.initials: H
authors.lastname: Shen
authors.forename: Bhupinderjit S
authors.initials: BS
authors.lastname: Anand
authors.forename: Edmund J
authors.initials: EJ
authors.lastname: Bini
authors.forename: Norbert
authors.initials: N
authors.lastname: Brau
authors.forename: Lennox
authors.initials: L
authors.lastname: Jeffers
authors.forename: Teresa L
authors.initials: TL
authors.lastname: Wright
mesh_terms: D000328:Adult; D000998:Antiviral Agents / Q000009:adverse effects; D004359:Drug Therapy, Combination; D005260:Female; D019698:Hepatitis C, Chronic / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D018579:Patient Selection; D015819:Substance Abuse, Intravenous; D016896:Treatment Outcome; D014481:United States; D014728:Veterans
chemical_list: D000998:Antiviral Agents