title: Chondrosarcoma involving the periodontum: clinicopathological and immunohistochemical features of a case study.
abstract: Chondrosarcoma is a rare flat bone neoplasm. Herein, we present the clinicopathological and immunohistochemical findings of a case affecting the periodontum. A 16-year-old girl presented a painless reddish mass in the lower anterior gingiva. Radiographs showed bone affected by vertical and horizontal loss and enlargement of periodontal space. The histopathological features showed atypical cartilage arranged in lobules compatible with chondrosarcoma. Immunohistochemistry showed that tumor cells were immunoreactive for the anti-vimentin and S-100 antibodies. Moreover, no tumor cells had been immunostained by anti-p53. Treatment consisted of chemotherapy, followed by radical surgery and postsurgery treatment with an association of radio and chemotherapy. After one year, no signs of recurrence have been observed.
authors.affiliation: Oral Pathology Unit, School of Dentistry, State University of Montes Claros, UNIMONTES Montes Claros, Minas Gerais, Brazil. pbonan@yahoo.com
authors.forename: P R
authors.initials: PR
authors.lastname: Ferreti Bonan
authors.forename: L A
authors.initials: LA
authors.lastname: Nogueira Dos Santos
authors.forename: A M
authors.initials: AM
authors.lastname: Batista De-Paula
authors.forename: R D
authors.initials: RD
authors.lastname: Coletta
authors.forename: H
authors.initials: H
authors.lastname: Martelli Jùnior
mesh_terms: D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002813:Chondrosarcoma / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D003131:Combined Modality Therapy; D003937:Diagnosis, Differential; D004317:Doxorubicin / Q000008:administration & dosage; D005260:Female; D005887:Gingival Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D006801:Humans; D007069:Ifosfamide / Q000008:administration & dosage; D008339:Mandibular Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D020360:Neoadjuvant Therapy; D018714:Radiotherapy, Adjuvant; D012074:Remission Induction
chemical_list: D004317:Doxorubicin; D007069:Ifosfamide