Beneficial effects of a three-month structured exercise training program on cardiopulmonary functional capacity in young women with polycystic ovary syndrome.
BACKGROUND
Polycystic ovary syndrome (PCOS) is an endocrine disease closely related to several risk factors for cardiovascular disease. An impaired cardiopulmonary functional capacity was previously demonstrated in PCOS women. No data regarding the effects of a structured exercise training (ET) program on cardiopulmonary functional capacity in PCOS women are available.


OBJECTIVE
Our objective was to evaluate the effects of a 3-month ET program on cardiopulmonary functional capacity in young PCOS women.


METHODS
A prospective baseline-randomized clinical study was conducted at the University "Federico II" of Naples, School of Medicine (Italy).


METHODS
Ninety young overweight PCOS women were enrolled.


METHODS
Ninety young PCOS women were randomly subdivided into two groups, each composed of 45 subjects. The PCOS-T (trained) group underwent a 3-month structured ET program, whereas the PCOS-UnT (untrained) group did not. Hormonal and metabolic profiles and cardiopulmonary and exercise parameters were evaluated.


RESULTS
After 3-month ET, PCOS-T showed a significant improvement in peak oxygen consumption (+35.4%; P<0.001) and in maximal workload (+37.2%; P<0.001). In PCOS-T we also observed a significant reduction in body mass index (-4.5%; P<0.001) and in C-reactive protein (-10%; P<0.001), and a significant (P<0.001) improvement in insulin sensitivity indexes. After 3 months, no changes were observed in PCOS-UnT.


CONCLUSIONS
A 3-month structured ET program improves cardiopulmonary functional capacity in young PCOS women.
Vigorito
Carlo
C
Department of Clinical Medicine, University Federico II of Naples, Italy.
Giallauria
Francesco
F
Palomba
Stefano
S
Cascella
Teresa
T
Manguso
Francesco
F
Lucci
Rosa
R
De Lorenzo
Anna
A
Tafuri
Domenico
D
Lombardi
Gaetano
G
Colao
Annamaria
A
Orio
Francesco
F
D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D015992:Body Mass Index; D002784:Cholesterol / Q000097:blood; D015444:Exercise; D005260:Female; D006334:Heart Function Tests; D006801:Humans; D007328:Insulin / Q000097:blood; D008074:Lipoproteins / Q000097:blood; D050177:Overweight; D010101:Oxygen Consumption; D010809:Physical Fitness; D011085:Polycystic Ovary Syndrome / Q000503:physiopathology* / Q000534:rehabilitation; D012129:Respiratory Function Tests; D016896:Treatment Outcome; D014280:Triglycerides / Q000097:blood; D015431:Weight Loss
D001786:Blood Glucose; D007328:Insulin; D008074:Lipoproteins; D014280:Triglycerides; D002784:Cholesterol