Study on a nanoparticle system for buccal delivery of insulin.
In this paper, a nanoparticle system of insulin (NSI) was prepared for buccal transmucosal delivery of insulin. The average size of the suspending particles was 67.5 nm, and a possible microstructure of the nanoparticles in the system was proposed. The transmucosal ability of insulin was evaluated in rabbits from the views of the hypoglycaemic rate and pharmacokinetics. The average bioavailability of NSI by buccal delivery versus subcutaneous injection is 18.3%. These results indicate that the studied nanoparticle system may be promising vehicles for the buccal delivery of insulin.
Luo
Yong
Y
Dept. of Chem., Huazhong Univ. of Sci. & Technol., Wuhan.
Xu
Huibi
H
Huang
Kaixun
K
Gao
Zhonghong
Z
Peng
Hong
H
Sheng
Xiqun
X