PEGylated dendritic architecture for development of a prolonged drug delivery system for an antitubercular drug.
The present study was aimed at developing and exploring the use of PEGylated poly (propylene imine) dendritic architecture for the delivery of an anti-tuberculosis drug, rifampicin. For this study, PEGylated poly(propylene imine) dendritic architecture was synthesized and loaded with rifampicin. Various physicochemical and physiological parameters UV, IR, NMR, TEM, DSC, drug entrapment, drug release and hemolytic toxicity of both PEGylated and non-PEGylated systems were determined and compared. The PEGylation of the systems was found to have increased their drug-loading capacity, reduced their drug release rate and hemolytic toxicity. The systems were found suitable for prolonged delivery of rifampicin.
Kumar
P Vijayaraj
PV
Pharmaceutics Research Laboratory, Department of Pharmaceutical Sciences, Dr. Hari Singh Gour University, Sagar-470 003, India. vijayarajkumar_p@yahoo.com
Agashe
Hrushikesh
H
Dutta
Tathagata
T
Jain
Narendra K
NK
D000995:Antitubercular Agents / Q000008:administration & dosage* / Q000737:chemistry; D001388:Aziridines / Q000737:chemistry*; D002152:Calorimetry, Differential Scanning / Q000379:methods; D003692:Delayed-Action Preparations / Q000008:administration & dosage / Q000737:chemistry; D050091:Dendrimers / Q000737:chemistry*; D016503:Drug Delivery Systems / Q000379:methods*; D004355:Drug Stability; D004356:Drug Storage; D004912:Erythrocytes / Q000187:drug effects; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D046529:Microscopy, Electron, Transmission / Q000379:methods; D008956:Models, Chemical; D010316:Particle Size; D012293:Rifampin / Q000008:administration & dosage / Q000737:chemistry; D013055:Spectrophotometry, Infrared / Q000379:methods; D013678:Technology, Pharmaceutical / Q000379:methods; D013696:Temperature; D013997:Time Factors; D014466:Ultraviolet Rays
D000995:Antitubercular Agents; D001388:Aziridines; D003692:Delayed-Action Preparations; D050091:Dendrimers; C031132:propyleneimine; D012293:Rifampin