title: Reduced complications during hemodialysis by automatic blood volume controlled ultrafiltration.
abstract: BACKGROUND
  Intradialytic morbid events (IMEs, mostly hypotension) are frequent complications during hemodialysis (HD). This study investigated whether automatic feedback control via adjustment of the ultrafiltration rate reduces IME frequency.
  
  
  METHODS
  In this multi-center cross-over study, 56 hypotension-prone patients were treated both with standard HD (sHD, applying a constant ultrafiltration rate) and HD applying a blood volume controlled ultrafiltration rate (cHD). The relative blood volume (RBV) was continuously monitored. The individual relative blood volume limit (RBVcrit ) was determined from the measured RBV during initial sHD. During cHD, the ultrafiltration rate was automatically adjusted to keep the actual RBV above RBVcrit.
  
  
  RESULTS
  In 3,081 HD treatments, slightly fewer IMEs were observed during cHD than during sHD (0.785+/-0.613 versus 0.695+/-0.547 per treatment, P=0.144). Less symptomatic events were seen during cHD: -13% for symptomatic hypotension (0.594 versus 0.685 per treatment, P=0.120), and -32% for cramps (0.049 versus 0.072 per treatment, P=0.009). Thirty-one patients with the highest IME rate (IME in at least every second treatment) especially benefited from cHD: 1.185+/-0.554 versus 0.979+/-0.543 IME per treatment (P=0.004). The reduction in blood pressure (BP) and the increase in heart rate were lower during the treatments with cHD than with sHD: systolic BP: -18.8+/-26.7 versus -22.2+/-28.9 mmHg (P=0.007), diastolic BP: -7.8+/-14.8 versus -9.1+/-15.3 mmHg (P=0.064), heart rate: 1.8+/-10.4 versus 2.3+/-11.6 per minute (P=0.014). Neither treatment duration nor ultrafiltration volume was significantly different between cHD and sHD.
  
  
  CONCLUSIONS
  For cHD, less intradialytic morbid events were observed than for sHD, and pre- to post-dialytic changes in blood pressure and heart rate were less pronounced.
authors.affiliation: Kantonsspital, St. Gallen, Switzerland, and University Hospital, Goettingen, Germany.
authors.forename: D
authors.initials: D
authors.lastname: Garzoni
authors.forename: G
authors.initials: G
authors.lastname: Keusch
authors.forename: T
authors.initials: T
authors.lastname: Kleinoeder
authors.forename: H
authors.initials: H
authors.lastname: Martin
authors.forename: A
authors.initials: A
authors.lastname: Dhondt
authors.forename: L
authors.initials: L
authors.lastname: Cremaschi
authors.forename: E
authors.initials: E
authors.lastname: Tatsis
authors.forename: N
authors.initials: N
authors.lastname: Ibrahim
authors.forename: W
authors.initials: W
authors.lastname: Boer
authors.forename: S
authors.initials: S
authors.lastname: Kuehne
authors.forename: M
authors.initials: M
authors.lastname: Claus
authors.forename: M
authors.initials: M
authors.lastname: Zahn
authors.forename: E
authors.initials: E
authors.lastname: Schuemann
authors.forename: J
authors.initials: J
authors.lastname: Engelmann
authors.forename: H
authors.initials: H
authors.lastname: Hickstein
authors.forename: R
authors.initials: R
authors.lastname: Wojke
authors.forename: A
authors.initials: A
authors.lastname: Gauly
authors.forename: J
authors.initials: J
authors.lastname: Passlick-Deetjen
mesh_terms: D000368:Aged; D001794:Blood Pressure; D001810:Blood Volume; D018592:Cross-Over Studies; D017583:Hemodiafiltration; D006801:Humans; D007022:Hypotension / Q000209:etiology; D009120:Muscle Cramp / Q000209:etiology; D006435:Renal Dialysis / Q000009:adverse effects* / Q000379:methods*; D014462:Ultrafiltration