title: Discordant response of glutathione and thioredoxin systems in human hypertension?
abstract: Hypertension is frequently associated with oxidative stress caused by high production of reactive oxygen species and compromised antioxidant defenses. Humans with essential hypertension, with or without treatment, and controls were examined (35 hypertensive and 30 normotensive). We noted a discordant response of the glutathione and thioredoxin systems in essential hypertension and to antihypertensive treatment. Further studies examining the significance of these thiols in hypertension outcomes are warranted.
authors.affiliation: Laboratorio de Estudios Genéticos. Fundación para la Investigación del Hospital Clínico, Valencia, Spain.
authors.forename: Maria L
authors.initials: ML
authors.lastname: Mansego
authors.forename: Sebastian
authors.initials: S
authors.lastname: Blesa
authors.forename: Veronica
authors.initials: V
authors.lastname: Gonzalez-Albert
authors.forename: Maria C
authors.initials: MC
authors.lastname: Tormos
authors.forename: Guillermo
authors.initials: G
authors.lastname: Saez
authors.forename: Josep
authors.initials: J
authors.lastname: Redon
authors.forename: Felipe J
authors.initials: FJ
authors.lastname: Chaves
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000378:metabolism; D005260:Female; D015870:Gene Expression; D005978:Glutathione / Q000097:blood / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000235:genetics* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D013879:Thioredoxins / Q000097:blood / Q000235:genetics* / Q000378:metabolism
chemical_list: D000975:Antioxidants; D012333:RNA, Messenger; D013879:Thioredoxins; D005978:Glutathione