title: Epstein-Barr virus early-antigen antibodies before allogeneic haematopoietic stem cell transplantation as a marker of risk of post-transplant lymphoproliferative disorders.
abstract: The occurrence of post-transplant lymphoproliferative disorders (PTLDs) after allogeneic haematopoietic stem cell transplantation (allo-HSCT) represents a clinical problem. Pretransplant Epstein-Barr virus serological status and viral load was determined in 21 recipients and 28 control transplanted patients, with (+) and without (-) PTLD, respectively. Early-antigen immunoglobulin G (EA-IgG) was detected in 12/21 PTLD+ patients, but only 2/28 PTLD patients (P = 0.00023, Odds ratio = 17.42). High viral load was detected in peripheral blood mononuclear cells at PTLD diagnosis, independently of deleted LMP1. Detection of EA-IgG in allo-HSCT recipients pretransplantation might be considered as risk factor for PTLD development.
authors.affiliation: Department of Microbiology, Saint-Louis Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France.
authors.forename: Felix
authors.initials: F
authors.lastname: Agbalika
authors.forename: Jerome
authors.initials: J
authors.lastname: Larghero
authors.forename: Helene
authors.initials: H
authors.lastname: Esperou
authors.forename: Dominique
authors.initials: D
authors.lastname: Marais
authors.forename: Marie
authors.initials: M
authors.lastname: Robin
authors.forename: Elena
authors.initials: E
authors.lastname: Foïs
authors.forename: Régis Peffault
authors.initials: RP
authors.lastname: de Latour
authors.forename: Eliane
authors.initials: E
authors.lastname: Gluckman
authors.forename: Vanderson
authors.initials: V
authors.lastname: Rocha
authors.forename: Marc
authors.initials: M
authors.lastname: Benbunan
authors.forename: Gerard
authors.initials: G
authors.lastname: Socié
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Marolleau
mesh_terms: D000293:Adolescent; D000328:Adult; D000741:Anemia, Aplastic / Q000601:surgery / Q000821:virology; D000914:Antibodies, Viral / Q000097:blood*; D000956:Antigens, Viral / Q000276:immunology*; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D002452:Cell Count; D002648:Child; D002675:Child, Preschool; D020031:Epstein-Barr Virus Infections / Q000175:diagnosis*; D005199:Fanconi Anemia / Q000601:surgery / Q000821:virology; D005260:Female; D005434:Flow Cytometry; D018380:Hematopoietic Stem Cell Transplantation; D004854:Herpesvirus 4, Human; D006801:Humans; D007938:Leukemia / Q000601:surgery / Q000821:virology; D008232:Lymphoproliferative Disorders / Q000209:etiology* / Q000821:virology; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000601:surgery / Q000821:virology; D016017:Odds Ratio; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D012698:Serologic Tests; D014184:Transplantation, Homologous; D019562:Viral Load
chemical_list: D000914:Antibodies, Viral; D000956:Antigens, Viral; D015415:Biomarkers; C033305:Epstein-Barr virus early antigen