title: Detection of oxidized low density lipoproteins by indium oxide nanowires-based field effect transistor.
abstract: Oxidized low density lipoprotein (oxLDL) particles are known to initiate the development of coronary artery disease. Field effect transistors (FET) made of indium oxide (In2O3) nanowires have been demonstrated as sensitive chemical sensors for gaseous molecules such as NO2 and NH3. We hereby, apply In2O3 nanowires FETs to differentiate oxLDL from native LDL (nLDL), cytochrome-c and bovine serum albumin in terms of the transistor characteristic curves: I(D)-V(GS) (current versus drain-source voltage) and I(D)-V(GS) (current versus gate-source voltage). Measurements under static and flow conditions revealed that exposure of nanowires to these redox proteins selectively changed the FET conductivity and the gating effect of the transistors. To enhance the selectivity for oxLDL detection, surface chemistry modification with antioxLDL antibody was performed.
authors.affiliation: Dept. of Biomedical Eng. & Cardiovascular Medicine, Southern California Univ., Los Angeles, CA 90089, USA.
authors.forename: Mahsa
authors.initials: M
authors.lastname: Rouhanizadeh
authors.forename: Tao
authors.initials: T
authors.lastname: Tang
authors.forename: Chao
authors.initials: C
authors.lastname: Li
authors.forename: Lucas
authors.initials: L
authors.lastname: DeMaio
authors.forename: Chongwu
authors.initials: C
authors.lastname: Zhou
authors.forename: Tzung
authors.initials: T
authors.lastname: Hsiai