title: Systematic review: oral bowel preparation for colonoscopy.
abstract: BACKGROUND
  There are many published trials of colon cleansing regimens for colonoscopy but no clear consensus regarding relative performance.
  
  
  OBJECTIVE
  To identify high quality controlled trials comparing two or more bowel preparation regimens and to compare efficacy and tolerability.
  
  
  METHODS
  A comprehensive systematic review was carried out to identify candidate studies. Quality appraisal was carried out on all identified studies. Results were meta-analysed where possible and qualitatively compared if not.
  
  
  RESULTS
  Eighty-two studies qualified for analysis. Polyethylene glycol and sodium phosphate were the most frequently investigated preparations. There was no significant efficacy difference between the two, but sodium phosphate was better tolerated. Sodium picosulphate/magnesium citrate, a commonly prescribed preparation, was investigated in four studies, with no clear benefit over other regimens demonstrated. Safety was not recognized as a problem in the randomized controlled trials. Published case series demonstrate that sodium phosphate is associated with the highest risk of clinically significant electrolyte disturbances.
  
  
  CONCLUSIONS
  Shortcomings in study design limit the value of many of the studies. Based on these results, no single bowel preparation emerges as consistently superior. New preparations are required that combine better efficacy and tolerability, in addition to rigorous new validated study designs, allowing unequivocal comparisons to be made.
authors.affiliation: JB Medical Ltd, The Old Brickworks, Little Cornard, Sudbury, UK. jbelsey@jbmedical.com
authors.forename: J
authors.initials: J
authors.lastname: Belsey
authors.forename: O
authors.initials: O
authors.lastname: Epstein
authors.forename: D
authors.initials: D
authors.lastname: Heresbach
mesh_terms: D000284:Administration, Oral; D002400:Cathartics / Q000008:administration & dosage*; D003113:Colonoscopy; D006801:Humans; D010710:Phosphates / Q000008:administration & dosage*; D011092:Polyethylene Glycols / Q000008:administration & dosage*; D011300:Preoperative Care / Q000379:methods; D016032:Randomized Controlled Trials as Topic
chemical_list: D002400:Cathartics; D010710:Phosphates; D011092:Polyethylene Glycols; C018279:sodium phosphate