[Effects of dust storm fine particles instillation on oxidative damage in hearts, livers, lungs of rats].
OBJECTIVE
In this study, the effects of dust storm PM2.5 on oxidative damage in three organs of rats were investigated.


METHODS
After Wistar rats were intratracheally instilled 24h, the activities of SOD, the levels of GSH and LPO in lungs, hearts and livers of rats were measured.


RESULTS
(1) Dust storm and normal weather PM2. instillation caused decrease of SOD activities in livers and lungs, but SOD activities in hearts were statistically insignificant. (2) Dust storm and normal weather PM2.5 instillation caused decrease of contents of GSH in lungs, whereas PM2.5, instillation at low concentration caused an increase and at higher PM2.5 instillation caused a significant decrease in livers. And contents of GSH in hearts were statistically insignificant. (3) Dust storm and normal weather PM2.5, instillation caused decrease of levels of LPO in lungs, hearts and livers. (4) Though the effects made by normal weather PM2.5 heavier than dust storm PM2.5 on each examined index, no significant difference was found. However, the dust storm PM2.5 whose airborne concentrations were much higher than that of normal weather PM2.5, so the dust storm PM2.5 should be more harmful.


CONCLUSIONS
Dust storm and normal weather PM2.5 instillation could lead to oxidative damage of different degrees in lungs,hearts and livers of rats. However, the dust storm PM2.5 whose airborne concentrations were much higher should be more harmful.
Meng
Zi-qiang
ZQ
Institute of Environmental Medicine and Toxicology, Shanxi University, Taiyuan 030006, China. zqmeng@sxu.edu.cn
Zhang
Quan-xi
QX
D000393:Air Pollutants / Q000633:toxicity*; D000818:Animals; D005978:Glutathione / Q000378:metabolism; D006321:Heart / Q000187:drug effects*; D008054:Lipid Peroxides / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008168:Lung / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000378:metabolism
D000393:Air Pollutants; D008054:Lipid Peroxides; D013482:Superoxide Dismutase; D005978:Glutathione