title: 1.8 cineole decreases gastric compliance in anesthetized rats.
abstract: OBJECTIVE
  To study the effect of 1,8 cineole components of the essential oil of Croton nepetaefolius--plant of North-East of Brasil, used in the popular medicine for riots of the gastrointestinal tract--on the motor behavior of the gut of Wistar rats.
  
  
  METHODS
  Used 16 male animals under jejun of 24h weighing 300-350 g. The effect of 1.8 cineole (1 or 3mg/Kg) on gastric compliance had been lead in anaesthetized rats. The variations of the gastric volume (GV), had been measured by plethysmography, while AP, HR and CVP had been monitored continuously by a digital system of data acquisition.
  
  
  RESULTS
  Observe reduction of the GV, which was significant on 30, 40, 50 and 60 min after treatment (2.0 +/- 0.1; 1.9 +/- 0.1; 1.8 +/- 0.1 and 1.7 +/- 0.1mL, versus 2.1 +/- 0.2mL). The AP presented significant fall after the administration of 1.8 cineole, remaining thus during 60min of monitorization (87.9 +/- 7.7; 87.6 +/- 7.1; 87.9 +/- 6.4; 87.8 +/- 5.7; 86.0 +/- 5.5 and 87.7 +/- 6.0mmHg, respectively versus 94.4 +/- 6.2 mmHg), as well as the HR (366.3 +/- 13.4; 361.7 +/- 11.5; 357.3 +/- 10.4; 353.0 +/- 10.4; 348.3 +/- 11.1 and 350.4 +/- 13.7bpm, respectively versus 395.2 +/- 11.1bpm). The CVP did not suffer significant variations after treatment.
  
  
  CONCLUSIONS
  Observe the 1.8 cineole reduces the gastric compliance in anaesthetized rats besides presenting effect hypotensor and bradycardia; probably for direct action on the gastrointestinal and vascular smooth muscle and moduling the autonomic nervous system.
authors.affiliation: Laboratory School Prof. Luiz Capelo, Department of Physiology and Pharmacology of the College of Medicine, Federal University of Ceará, Brazil.
authors.forename: José Ricardo Cunha
authors.initials: JR
authors.lastname: Neves
authors.forename: Gislano Heverton Soares de
authors.initials: GH
authors.lastname: Lira
authors.forename: Rocino Marinho de
authors.initials: RM
authors.lastname: Oliveira Neto
authors.forename: José Ronaldo Vasconcelos da
authors.initials: JR
authors.lastname: Graça
authors.forename: Paulo Roberto Leitão de
authors.initials: PR
authors.lastname: Vasconcelos
authors.forename: Miguel Angelo
authors.initials: MA
authors.lastname: Nobre e Souza
authors.forename: Pedro Jorge Caldas
authors.initials: PJ
authors.lastname: Magalhães
authors.forename: Francisco Hélio
authors.initials: FH
authors.lastname: Rola
authors.forename: Armênio Aguiar dos
authors.initials: AA
authors.lastname: Santos
mesh_terms: D000704:Analysis of Variance; D000768:Anesthesia, General; D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D002496:Central Venous Pressure / Q000187:drug effects; D003187:Compliance / Q000187:drug effects; D003436:Croton Oil / Q000494:pharmacology*; D003511:Cyclohexanols / Q000494:pharmacology; D000077591:Eucalyptol; D015905:Gastric Balloon; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D023421:Models, Animal; D039821:Monoterpenes / Q000494:pharmacology; D010991:Plethysmography; D051381:Rats; D017208:Rats, Wistar; D013270:Stomach / Q000187:drug effects* / Q000502:physiology; D013997:Time Factors
chemical_list: D000890:Anti-Infective Agents; D003511:Cyclohexanols; D039821:Monoterpenes; D003436:Croton Oil; D000077591:Eucalyptol