Bone repair in rats treated with sodic diclofenac and calcitonin.
OBJECTIVE
To investigate clinical and histologically the bone repair in treated animals with calcitonin and sodic diclofenac.


METHODS
Ninety-six femoral defects were created in forty-eight animals distributed in four groups (n=24): either left untreated, treated with the sodic diclofenac or calcitonin or both. Follow-up was 7, 14 and 21 days. Histological sections stained by haematoxylin-eosin was observed under light microscopy (100X) and quantitatively scored for their trabecular formation. The groups and subgroups were compared being used the Kruskall-Wallis test.


RESULTS
Smaller trabecular formation was observed in the animals of the group II and larger trabecular formation in the animals of the group III. Was found significant differences in the comparison between all the groups (Kruskall-Wallis, p <0.05).


CONCLUSIONS
The obtained data suggest that the bone repair is a time-dependent process, which can be delayed by the sodic diclofenac and accelerated by the calcitonina, when used separately. The associated use of calcitonina and sodic diclofenac didn't show to be the best therapeutic option in the treatment of bone defects surgically created.
Sassioto
Maria Cristina Pita
MC
Health and Development in the West Central Region, UFMS, Brazil.
Inouye
Celso Massaschi
CM
Aydos
Ricardo Dutra
RD
Figueiredo
Arthur Silveira de
AS
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D050071:Bone Density Conservation Agents / Q000627:therapeutic use*; D001861:Bone Regeneration / Q000187:drug effects / Q000502:physiology*; D002116:Calcitonin / Q000627:therapeutic use*; D004008:Diclofenac / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D000894:Anti-Inflammatory Agents, Non-Steroidal; D050071:Bone Density Conservation Agents; D004008:Diclofenac; D002116:Calcitonin