[Radiation optic neuropathy after the brachytherapy of the uveal melanoma].
OBJECTIVE
The evaluate the frequency of radiation of the optic neuropathy (RON) and its influence on visual acuity in patients with choroidal melanoma treated by brachytherapy.


METHODS
We analyzed 583 patients with choroidal melanoma, treated with ruthenium (106Ru) or iodine (125I) plaques in Ophthalmology Department of Jagiellonian University, between 1996 and 2004 year. The frequency of RON, its influence on loss of vision, according to a kind of the used isotope, tumor size and location were analyzed. Diagnosis of RON was established on the base of characteristic symptoms in the eye fundus.


RESULTS
The frequency of RON was significantly higher in cases treated by 125I vs 106Ru (14% vs 8.2%, p = 0.0014), in cases of tumors located in the posterior pole (31.3%, p = 0.012), and in cases of tumor thickness 3-8 mm (27.5%, p = 0.033). In most of patients we observed major deterioration of visual acuity.


CONCLUSIONS
The radiation of the optic neuropathy was seen often after iodine BT, tumors located in the posterior pole of fundus, with thickness 3-8 mm.
Szuścik
Iwona
I
Katedry i Kliniki Okulistyki, Collegium Medicum Uniwersytetu Jagiellońskiego w Krakowie.
Romanowska-Dixon
Bozena
B
Markiewicz
Anna
A
Pogrzebielski
Arkadiusz
A
Jakubowska
Barbara
B
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001918:Brachytherapy / Q000009:adverse effects*; D002830:Choroid Neoplasms / Q000532:radiotherapy*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use; D008297:Male; D008545:Melanoma / Q000532:radiotherapy*; D008875:Middle Aged; D009900:Optic Nerve / Q000473:pathology / Q000528:radiation effects*; D009901:Optic Nerve Diseases / Q000209:etiology*; D011832:Radiation Injuries / Q000209:etiology* / Q000473:pathology; D012189:Retrospective Studies; D012429:Ruthenium Radioisotopes / Q000627:therapeutic use; D016896:Treatment Outcome; D014792:Visual Acuity / Q000528:radiation effects
D007457:Iodine Radioisotopes; D012429:Ruthenium Radioisotopes