title: Update on multi-center clinical trials in the United States.
abstract: This article reviews numerous multi-center clinical trials, either ongoing or in planning stages, which involve diverse clinical applications and emerging technologies in apheresis and transfusion medicine. The investigations summarized herein involve the following specific areas: platelet dosing strategy, thrombotic thrombocytopenia purpura, inflammatory bowel disease, seven-day platelet storage, dendritic cell vaccines, and age-related macular degeneration.
authors.affiliation: University of North Carolina Hospitals, 101 Manning Drive, 1021 East Wing, Blood Bank, CB#7525, Chapel Hill, NC 27514, USA. araba_afenyi-annan@med.unc.edu
authors.forename: Araba
authors.initials: A
authors.lastname: Afenyi-Annan
authors.forename: Mark E
authors.initials: ME
authors.lastname: Brecher
authors.forename: Nicholas
authors.initials: N
authors.lastname: Bandarenko
mesh_terms: D001781:Blood Component Removal / Q000592:standards / Q000639:trends; D001792:Blood Platelets / Q000166:cytology; D003713:Dendritic Cells / Q000166:cytology / Q000637:transplantation; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000628:therapy*; D008268:Macular Degeneration / Q000628:therapy*; D015337:Multicenter Studies as Topic / Q000592:standards / Q000639:trends; D017713:Platelet Transfusion / Q000592:standards / Q000639:trends; D011309:Preservation, Biological / Q000592:standards / Q000639:trends; D011697:Purpura, Thrombotic Thrombocytopenic / Q000628:therapy*