Methylprednisolone administration alters adenine nucleotide hydrolysis in rat blood serum.
The effect of methylprednisolone on the hydrolysis of adenine nucleotides by rat blood serum enzymes was studied. Adult male Wistar rats were submitted to three different treatments with synthetic steroid methylprednisolone: one dose of 50 mg/kg, i.p. (acute); or oral doses of 6 mg/kg dissolved in drinking water for 15 (sub-chronic) or 30 (chronic) days. Decreased ADP hydrolysis was observed after acute and sub-chronic treatments. Furthermore, ATP, ADP and AMP hydrolysis decreased after chronic treatment. These alterations may constitute one of the mechanisms that mediate the development of some of the side effects associated with corticosteroid use.
Torres
Iraci Lucena S
IL
Departamentos de Farmacologia, Instituto de Ciências Básicas da Saúde, UFRGS, Rua Sarmiento Leite 500, 90050-170 Porto Alegre, RS, Brazil. iracitorres@gmail.com
Fürstenau
Cristina Ribas
CR
Rossi
Gabriela
G
Dallegrave
Eliane
E
Dallegrave
Gustavo
G
Stenzel
Barbara
B
Dantas
Giovana
G
Battastini
Ana Maria O
AM
Sarkis
João J F
JJ
Ferreira
Maria Beatriz C
MB
D000227:Adenine Nucleotides / Q000097:blood*; D000375:Aging / Q000378:metabolism; D000818:Animals; D006868:Hydrolysis; D008297:Male; D008775:Methylprednisolone / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D000227:Adenine Nucleotides; D008775:Methylprednisolone