title: Four-dimensional computed tomography-based respiratory-gated whole-abdominal intensity-modulated radiation therapy for ovarian cancer: a feasibility study.
abstract: This study assesses the feasibility and implementation of respiratory-gated whole-abdominal intensity-modulated radiation therapy (RG-WAIMRT). Three patients were treated with RG-WAIMRT. The planning target volume (PTV1) included the entire peritoneal cavity and a pelvic boost field was created (PTV2). The dose prescribed was 30 Gy to PTV1 and 14.4 Gy to PTV2. For comparison, a conventional three-dimensional (3D) plan was generated for each patient. In the WAIMRT plan, an average of 90% of PTV1 received 30 Gy compared to 70% for the conventional 3D plan. The percent volume receiving 30 Gy (V(30)) for liver averaged 54% (WAIMRT) vs 43% (3D). The percent volume receiving 20 Gy (V(20)) for kidneys averaged 19% vs 0%, and the mean V(20) for bone marrow was 74% vs 83%, respectively. Major acute toxicities were anemia (grade 2: 1/3), leukopenia (grade 3: 2/3 patients), and thrombocytopenia (grade 2: 1/3 patients, grade 3: 1/3 patients). One patient could not complete the whole-abdomen field after 19.5 Gy because of persistent nausea. No major subacute toxicity has been reported. WAIMRT demonstrated superior target coverage and reduced dose to bone marrow, with a slightly increased dose to liver and kidneys. WAIMRT is a novel and feasible technique for ovarian cancer treatment.
authors.affiliation: University of Pittsburgh School of Medicine, Pittsburgh, PA 15232, USA.
authors.forename: A A
authors.initials: AA
authors.lastname: Garsa
authors.forename: R S
authors.initials: RS
authors.lastname: Andrade
authors.forename: D E
authors.initials: DE
authors.lastname: Heron
authors.forename: S
authors.initials: S
authors.lastname: Beriwal
authors.forename: H
authors.initials: H
authors.lastname: Kim
authors.forename: E
authors.initials: E
authors.lastname: Brandner
authors.forename: G
authors.initials: G
authors.lastname: Kuo
authors.forename: H
authors.initials: H
authors.lastname: Chen
authors.forename: K
authors.initials: K
authors.lastname: Gerszten
authors.forename: J N
authors.initials: JN
authors.lastname: Yue
authors.forename: M S
authors.initials: MS
authors.lastname: Huq
authors.forename: J
authors.initials: J
authors.lastname: Lee
authors.forename: R
authors.initials: R
authors.lastname: Lalonde
authors.forename: A
authors.initials: A
authors.lastname: Wu
mesh_terms: D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D011880:Radiotherapy Planning, Computer-Assisted; D050397:Radiotherapy, Intensity-Modulated / Q000009:adverse effects / Q000379:methods; D012119:Respiration; D014057:Tomography, X-Ray Computed / Q000379:methods