title: The rag locus of Porphyromonas gingivalis contributes to virulence in a murine model of soft tissue destruction.
abstract: The rag locus of Porphyromonas gingivalis encodes a putative TonB-dependent outer membrane receptor, RagA, and a 55-kDa immunodominant antigen, RagB. Inactivation of either ragA or ragB prevented expression of both RagA and RagB. Both the ragA and ragB mutants were significantly less virulent than wild-type strains in a murine model of infection.
authors.affiliation: Centre for Infectious Disease, Institute of Cell and Molecular Science, Barts and The London School of Medicine and Dentistry, 4 Newark Street, London E1 2AT, United Kingdom.
authors.forename: Xiaoju
authors.initials: X
authors.lastname: Shi
authors.forename: Shirley A
authors.initials: SA
authors.lastname: Hanley
authors.forename: Marie-Claire
authors.initials: MC
authors.lastname: Faray-Kele
authors.forename: Stuart C
authors.initials: SC
authors.lastname: Fawell
authors.forename: Joseph
authors.initials: J
authors.lastname: Aduse-Opoku
authors.forename: Robert A
authors.initials: RA
authors.lastname: Whiley
authors.forename: Michael A
authors.initials: MA
authors.lastname: Curtis
authors.forename: Lucinda M C
authors.initials: LM
authors.lastname: Hall
mesh_terms: D000818:Animals; D001426:Bacterial Proteins / Q000235:genetics / Q000502:physiology*; D016866:Bacteroidaceae Infections / Q000382:microbiology*; D004195:Disease Models, Animal; D017353:Gene Deletion; D051379:Mice; D016966:Porphyromonas gingivalis / Q000235:genetics* / Q000472:pathogenicity*; D014774:Virulence / Q000235:genetics; D037521:Virulence Factors / Q000235:genetics / Q000502:physiology*
chemical_list: D001426:Bacterial Proteins; C484343:RagA protein, Porphyromonas gingivalis; C484346:RagB protein, bacteria; D037521:Virulence Factors