[Evaluation of the use of raw extract of Jatropha gossypiifolia L. in the healing process of skin wounds in rats].
BACKGROUND
Phytotherapy is one of the research branches in the healing process of surgical wounds.


OBJECTIVE
To analyze the morphological aspects of the healing process occurring in open skin lesions in rats under administration of raw extract from Jatropha Gossypiifolia L.


METHODS
Sixty Wistar rats were utilized. A 2 cm wound in diameter was done in each animal at the dorsal region. The animals were divided into two groups, each one consisting of 30 animals. Each group was subdivided into three subgroups of ten. They were analyzed in the 7th, 14th and 21st post-operative day. The two groups were compared through macroscopic analysis using digital planigraphy and histological examination. The microscopic parameters considered were the vascular proliferation, polymorph and mononuclear cells, fibroblastic proliferation, collagen and epithelium formation.


RESULTS
Epithelization occurred in a same amount in all animals. There was no chronic inflammation on 21st day in the Jatropha group and also no difference in polymorphonuclear cells between the groups. The fibroblastic reaction was better on the 7th day in the Jatropha group and equal in the remaining ones. Colagenization was greater on 7th and 14th days in Jatropha and better re-epithelization occurred in the same group in the 7th day.


CONCLUSIONS
Although with histologic aspects favoring the Jatropha, no significant differences concerning to the macroscopic and microscopic aspects were observed among the skin wounds receiving raw extract Jatropha and those that received no treatment in the final evaluation.
Santos
Manoel Francisco da Silva
MF
Departamento de Cirurgia, Universidade Federal do Maranhao.
Czeczko
Nicolau Gregori
NG
Nassif
Paulo Afonso Nunes
PA
Ribas-Filho
Jurandir Marcondes
JM
Alencar
Bruno Leonardi Freire de
BL
Malafaia
Osvaldo
O
Ribas
Carmen Australia Paredes Marcondes
CA
Trautwein
Vagner Marcolin
VM
Henriques
Gilberto Simeone
GS
Maia
José Maria Ayres
JM
Bittencourt
Ruy Carlos de Araújo
RC
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D007249:Inflammation / Q000188:drug therapy / Q000473:pathology; D031286:Jatropha / Q000737:chemistry*; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D012867:Skin / Q000187:drug effects / Q000293:injuries* / Q000648:ultrastructure; D018709:Statistics, Nonparametric; D014945:Wound Healing / Q000187:drug effects* / Q000502:physiology
D000893:Anti-Inflammatory Agents; D010936:Plant Extracts