title: Large submacular hemorrhage following PDT with verteporfin in patients with occult CNVM secondary to age-related macular degeneration.
abstract: A review of the charts for all patients who developed large submacular hemorrhages following photodynamic therapy for choroidal neovascular membranes secondary to age-related macular degeneration yielded three patients who met the criteria for a large submacular hemorrhage. All three patients were treated for exudative age-related macular degeneration and were taking warfarin for chronic anticoagulation. Before photodynamic therapy, the international normalized ratio ranged from 1.2 to 1.6. All three patients had received at least one previous verteporfin treatment in the study eye. All three hemorrhages were not noted immediately after photodynamic therapy and were documented within 1 to 2 weeks following the procedure. Patients with age-related macular degeneration who are receiving warfarin therapy and undergoing repeat verteporfin treatments appear to be at risk for submacular hemorrhages.
authors.affiliation: New England Retina Associates, Hamden, Connecticut 06518, USA.
authors.forename: Nauman A
authors.initials: NA
authors.lastname: Chaudhry
authors.forename: Alejandro J
authors.initials: AJ
authors.lastname: Lavaque
authors.forename: David E
authors.initials: DE
authors.lastname: Tom
authors.forename: Peter E
authors.initials: PE
authors.lastname: Liggett
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D020256:Choroidal Neovascularization / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D005451:Fluorescein Angiography; D005500:Follow-Up Studies; D005654:Fundus Oculi; D006801:Humans; D007267:Injections; D008268:Macular Degeneration / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D010778:Photochemotherapy / Q000009:adverse effects*; D017319:Photosensitizing Agents / Q000009:adverse effects* / Q000627:therapeutic use; D011166:Porphyrins / Q000009:adverse effects* / Q000627:therapeutic use; D012166:Retinal Hemorrhage / Q000139:chemically induced* / Q000473:pathology / Q000601:surgery; D012720:Severity of Illness Index; D013459:Sulfur Hexafluoride / Q000008:administration & dosage; D000077362:Verteporfin; D014792:Visual Acuity; D014821:Vitrectomy; D014822:Vitreous Body
chemical_list: D017319:Photosensitizing Agents; D011166:Porphyrins; D000077362:Verteporfin; D013459:Sulfur Hexafluoride