[Electrophysiological effects of acehytisine hydrochloride in a porcine model of acute coronary occlusion].
OBJECTIVE
To observe the electrophysiological effect of Acehytisine Hydrochloride (AHH) in Wu Zhi Shan (WZS) micropigs with experimental acute coronary occlusion.


METHODS
Adult WZS micropigs were randomized into group A: coronary ligation with AHH infusion (n = 9); group B: AHH infusion without coronary ligation (n = 9) and group C: coronary ligation with saline (NS) infusion (n = 9). Surface ECGs and cardiac electrophysiological data including atrium, atrium-ventricle junction and ventricle electrograms were collected by programmed electrical stimulation at ischemic baseline and after AHH (or NS) infusion.


RESULTS
Compared to animals treated with AHH without ischemia, VARC-ERP was significantly increased while QT, QTc intervals, VRRP and VFRP were significantly reduced in ischemic animals treated with AHH. Compared to ischemic animals treated with saline, AHH prolongs the P-wave duration and PR interval, shortens QTc interval, prolongs ARP and AEP, also prolongs V-A reverse conduction time and VARC-ERP but shortens VFRP. No proarrhythmia effect was found in both AHH treated groups.


CONCLUSIONS
AHH resulted in significant electrophysiological effects on this porcine acute coronary ischemic model.
Liang
Yan
Y
Emergency Division, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.
Zhu
Jun
J
Yang
Yan-min
YM
Li
Jian-dong
JD
Sun
Yan
Y
Guan
Jian
J
Gao
Xin
X
Li
Chang-rui
CR
Tang
Yue
Y
D031841:Aconitum; D000818:Animals; D003327:Coronary Disease / Q000188:drug therapy / Q000503:physiopathology*; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D004594:Electrophysiology; D005260:Female; D008297:Male; D008517:Phytotherapy; D011897:Random Allocation; D013552:Swine; D013556:Swine, Miniature
D004365:Drugs, Chinese Herbal