Molecular imaging of carcinogenesis with immuno-targeted nanoparticles.
Molecular characterization of cancer could have important clinical benefits such as earlier cancer detection based on molecular characterization, the ability to predict the risk of cancer progression, real time margin detection, the ability to rationally select molecular therapy and to monitor response to the therapy. We present a new class of molecular specific contrast agents for optical imaging of carcinogenesis in vivo - gold nanoparticles conjugated with monoclonal antibodies specific for cancer biomarkers.
Sokolov
K
K
Department of Imaging Physics, Texas University, Houston, TX, USA.
Aaron
J
J
Kumar
S
S
Mack
V
V
Collier
T
T
Coghlan
L
L
Gillenwater
A
A
Adler Storthz
K
K
Follen
M
M
Richards Kortum
R
R