[Incidence of pneumonia in HIV-infected patients in the highly active antiretroviral therapy era].
OBJECTIVE
There is scant data comparing the incidence of pneumonia in the community and in the human immunodeficiency virus (HIV) population in highly active antiretroviral therapy (HAART) era.


METHODS
Prospective study during 18 months. Data were obtained by the means of the electronic clinical record. Incidence rate was compared between HIV positive and negative patients.


RESULTS
There were 529 pneumonia episodes in global population (n = 220,000), 1.6 cases/1000 person-year. HIV-infected patients (n = 170) suffered 12 episodes of pneumonia; 46 cases/1000 person-year (relative risk = 29.3, 95% confidence interval, 16.34-51.4; p < 0.01). HIV infected patients with pneumonia have a lower CD4 count (mean 434 versus 230 cells/ml; p = 0.04), higher viral load (4.1 versus 3.2 log copies/ml; p = 0.07) and received antiretroviral treatment in a similar proportion compared to HIV without pneumonia (62 versus a 66.7%, p = 0.5).


CONCLUSIONS
Pneumonia in HIV infected patients may be about 30 times more frequent than general population in HAART era. Prevention measures should be reinforced.
Velasco Arribas
María
M
Sección de Infecciosas, Servicio de Medicina Interna, Fundación Hospital Alcorcón, Alcorcón, Madrid, España. mvelasco@fhalcorcon.es
Satué Bartolomé
José Angel
JA
Losa García
Juan Emilio
JE
Espinosa Gimeno
Alfredo
A
Delgado-Iribarren
Alberto
A
Castilla Castellano
Virgilio
V
D000328:Adult; D023241:Antiretroviral Therapy, Highly Active; D005260:Female; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D015994:Incidence; D008297:Male; D018410:Pneumonia, Bacterial / Q000453:epidemiology* / Q000209:etiology*; D011446:Prospective Studies