title: Photoproducts and proposed degradation pathway in the riboflavin-sensitised photooxidation of isoproterenol.
abstract: Products of the aerobic visible-light-promoted riboflavin-sensitised photooxidation of the sympathomimetic drug isoproterenol were identified by means of HPLC and spectrophotometric techniques. The oxidative process, mediated by superoxide radical anion, generates N-isopropylaminochrome as a main photoproduct with a quantum yield of 0.15. In parallel, the photodecomposition of riboflavin is prevented in the presence of isoproterenol. A reaction scheme for the photooxidation pathway of isoproterenol is proposed in analogy to former reports for related compounds.
authors.affiliation: Departamento de Química, Facultad de Ciencias Exactas, Fisicoquímicas y Naturales, Universidad Nacional de Río Cuarto, 5800 Río Cuarto, Argentina. wmassad@exa.unrc.edu.ar
authors.forename: W A
authors.initials: WA
authors.lastname: Massad
authors.forename: J M
authors.initials: JM
authors.lastname: Marioli
authors.forename: N A
authors.initials: NA
authors.lastname: García
mesh_terms: D000318:Adrenergic beta-Agonists / Q000737:chemistry* / Q000528:radiation effects*; D000465:Algorithms; D002851:Chromatography, High Pressure Liquid; D007545:Isoproterenol / Q000737:chemistry* / Q000528:radiation effects*; D009682:Magnetic Resonance Spectroscopy; D010084:Oxidation-Reduction; D010777:Photochemistry; D010782:Photolysis; D017319:Photosensitizing Agents / Q000737:chemistry*; D012256:Riboflavin / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet
chemical_list: D000318:Adrenergic beta-Agonists; D017319:Photosensitizing Agents; D007545:Isoproterenol; D012256:Riboflavin