Angiotensin-converting enzyme inhibitor fetopathy: long-term outcome.
Fetal exposure to angiotensin-converting enzyme inhibitors (ACEIs) is associated with increased neonatal morbidity and mortality. Long-term follow-up of three patients with fetal ACEI exposure revealed impaired renal function in two, severe hypertension and proteinuria in one and isolated polycythaemia in all three. Careful long-term follow-up of children with ACEI fetopathy is recommended.
Laube
Guido F
GF
University Children's Hospital, Steinwiesstrasse 75, CH-8032 Zurich, Switzerland. guido.laube@kispi.unizh.ch
Kemper
Markus J
MJ
Schubiger
Gregor
G
Neuhaus
Thomas J
TJ
D000293:Adolescent; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000009:adverse effects*; D002648:Child; D004656:Enalapril / Q000009:adverse effects*; D005260:Female; D005333:Fetus / Q000187:drug effects*; D006801:Humans; D006973:Hypertension / Q000139:chemically induced; D007674:Kidney Diseases / Q000139:chemically induced; D008297:Male; D011086:Polycythemia / Q000139:chemically induced; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D011507:Proteinuria / Q000139:chemically induced
D000806:Angiotensin-Converting Enzyme Inhibitors; D004656:Enalapril