title: An integrated model describing the toxic responses of Daphnia magna to pulsed exposures of three metals.
abstract: Some toxicology research in which toxicant exposures are continual (pulsed) rather than continuous have been reported. A number of toxicity models have been developed for pulsed and continuous exposures. Most of these models were developed based on one- or two-compartment, first-order toxicokinetics and were calibrated with organic compounds. In the present study, the relationship between mortality (after 21 d) of Daphnia magna in response to pulsed and continuous exposures to Cu, Zn, and Se was used to develop a model that integrated the effects of single and multiple pulsed metal exposures based on first-order uptake and depuration kinetics. Mortality was a function of exposure concentration, duration, and recovery time between exposures. The model was successfully validated using an independent data set. It is applicable to risk assessment and, potentially, may be incorporated with other models (e.g., the biotic ligand model) to predict the toxicity of pulsed metal exposures under a range of environmental conditions.
authors.affiliation: Department of Biological Sciences, Institute of Environmental Toxicology, Clemson University, Pendleton, South Carolina 29670, USA. hoangt@fiu.edu
authors.forename: Tham C
authors.initials: TC
authors.lastname: Hoang
authors.forename: Joseph R
authors.initials: JR
authors.lastname: Tomasso
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Klaine
mesh_terms: D000818:Animals; D003621:Daphnia / Q000187:drug effects*; D008670:Metals / Q000633:toxicity*; D008962:Models, Theoretical; D014874:Water Pollutants, Chemical / Q000633:toxicity*
chemical_list: D008670:Metals; D014874:Water Pollutants, Chemical