Chemical genetics: where genetics and pharmacology meet.
Genetics and pharmacology can elicit surprisingly different phenotypes despite targeting the same protein. This Essay explores these unexpected differences and their implications for biology and medicine.
Knight
Zachary A
ZA
Howard Hughes Medical Institute, Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94143, USA.
Shokat
Kevan M
KM
D000494:Allosteric Regulation; D000818:Animals; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D005821:Genetic Techniques; D009154:Mutation; D010641:Phenotype; D010770:Phosphotransferases / Q000037:antagonists & inhibitors / Q000187:drug effects* / Q000235:genetics* / Q000378:metabolism; D011506:Proteins / Q000187:drug effects / Q000235:genetics / Q000378:metabolism
D004791:Enzyme Inhibitors; D011506:Proteins; D010770:Phosphotransferases