title: [Cutaneous manifestations of paraproteinemia and their mechanisms].
abstract: Disease entities characterized by the presence of paraproteins have a variety of cutaneous manifestations. These manifestations may be classified in the following categories as a function of their mechanisms: * extracutaneous deposition of paraproteins, as in amyloidosis * intravascular paraprotein deposition, as in cryoglobulinemia * cutaneous lesions resulting from the biologic activity of paraprotein, as in patients with normolipemic xanthoma with monoclonal immunoglobulin anti-LDL activity * abnormal cytokine secretion, as in AESOP (adenopathy and extensive skin patch overlying a plasmacytoma) or POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, and skin changes) syndromes * unknown mechanisms.
authors.affiliation: Clinique dermatologique et Faculté de médecine, Université Louis Pasteur, Strasbourg. dlipsker@noos.fr
authors.forename: Dan
authors.initials: D
authors.lastname: Lipsker
authors.forename: Peggy
authors.initials: P
authors.lastname: Boeckler
mesh_terms: D000686:Amyloidosis / Q000209:etiology; D001797:Blood Protein Electrophoresis; D003449:Cryoglobulinemia / Q000209:etiology; D016207:Cytokines / Q000502:physiology; D003937:Diagnosis, Differential; D006801:Humans; D007122:Immunoelectrophoresis; D007136:Immunoglobulins / Q000502:physiology; D016878:POEMS Syndrome / Q000209:etiology; D010265:Paraproteinemias / Q000145:classification / Q000150:complications* / Q000175:diagnosis*; D018579:Patient Selection; D011693:Purpura / Q000209:etiology; D012307:Risk Factors; D019873:Schnitzler Syndrome / Q000209:etiology; D012871:Skin Diseases / Q000145:classification / Q000209:etiology* / Q000473:pathology; D014581:Urticaria / Q000209:etiology; D014657:Vasculitis / Q000209:etiology; D014973:Xanthomatosis / Q000209:etiology
chemical_list: D016207:Cytokines; D007136:Immunoglobulins