title: Cryografts implantation in human circulation would ensure a physiological transition in the arterial wall energetics, damping and wave reflection.
abstract: Each artery conduces blood (conduit function, CF) and smoothes out the pulsatility (buffering function, BF), while keeping its wall protected against the high oscillations of the pulse waves (damping function, xi). These functions depend on each segment viscoelasticity and capability to store and dissipate energy. When a graft/prosthesis is implanted, the physiological gradual transition in the viscoelasticity and functionality of adjacent arterial segments is disrupted. It remains to be elucidated if the cryografts would allow keeping the physiological biomechanical transition. The aim of this study was to evaluate the cryografts capability to reproduce the functional, energetic and reflection properties of patients' arteries and fresh homografts. Common carotid's pressure, diameter and wall-thickness were recorded in vivo (15 patients) and in vitro (15 cryografts and 15 fresh homografts from donors). Calculus: elastic (Epd) and viscous (Vpd) indexes, CF, BF, dissipated (WD) and stored (WPS) energy and xi. The graft-patient's artery matching was evaluated using the reflection coefficient (Gamma) and reflected power (WGamma). Cryografts did not show differences in Epd, Vpd, BF, CF, WD, WPS, and xi, in respect to fresh homografts and patients' arteries, ensuring a reduced Gamma and WGamma. Cryografts could be considered as alternatives in arterial reconstructions since they ensure the gradual transition of patients' arteries biomechanical and functional behavior.
authors.affiliation: Departamento de Fisiología, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay. dbia@fmed.edu.uy
authors.forename: D
authors.initials: D
authors.lastname: Bia
authors.forename: J G
authors.initials: JG
authors.lastname: Barra
authors.forename: R L
authors.initials: RL
authors.lastname: Armentano
authors.forename: Y
authors.initials: Y
authors.lastname: Zócalo
authors.forename: H
authors.initials: H
authors.lastname: Pérez
authors.forename: M
authors.initials: M
authors.lastname: Saldías
authors.forename: I
authors.initials: I
authors.lastname: Alvarez
authors.forename: E I
authors.initials: EI
authors.lastname: Cabrera Fischer
mesh_terms: D000328:Adult; D001705:Bioprosthesis; D001794:Blood Pressure; D001807:Blood Vessel Prosthesis; D019917:Blood Vessel Prosthesis Implantation / Q000295:instrumentation*; D017536:Carotid Artery, Common / Q000000981:diagnostic imaging / Q000502:physiology* / Q000637:transplantation; D015925:Cryopreservation; D004548:Elasticity; D006339:Heart Rate; D006801:Humans; D008297:Male; D008422:Materials Testing; D008875:Middle Aged; D008955:Models, Cardiovascular; D011474:Prosthesis Design; D011673:Pulsatile Flow; D013314:Stress, Mechanical; D014463:Ultrasonography