title: A software environment for simulators suitable for complex biological analysis.
abstract: In order to understand the function of biological elements and their interactions, computer analysis and simulation is an essential technique. For higher research efficiency, it is important to provide a system framework for constructing biological simulation systems that handle multiple phenomena. This paper proposes "DynaBioS", a comprehensive system framework for complex biological simulations. This framework consists of three main features, a component-based architecture, a customizable system operation, and an exchangeable model set. The system based on DynaBioS consists of a simulation core and system components. The system components are sub-simulators for individual functional factors and utility modules corresponding to specific information technologies. The simulation core manages and controls all components, in accordance with a simulation scenario and a simulation model. The DynaBioS makes it possible to implement different simulation systems by combining individual functional components, specific interactions and different simulation models. The versatility of DynaBioS is shown by two examples, a heart pumping simulator and a parameter optimization system for physiological models.
authors.affiliation: ASTEM, Kyoto, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Shimayoshi
authors.forename: K
authors.initials: K
authors.lastname: Hori
authors.forename: J Y
authors.initials: JY
authors.lastname: Lu
authors.forename: A
authors.initials: A
authors.lastname: Amano
authors.forename: T
authors.initials: T
authors.lastname: Matsuda