title: Noninvasive Multimodality Imaging Techniques to Assess Kaposi's Sarcoma.
abstract: We evaluated three non-invasive method, thermography, laser Doppler imaging and near infrared multi-spectral imaging to quantitatively assess parameters of vascularity in Kaposi's sarcoma. The KS lesion generally has increased temperature, blood velocity and blood deoxy-hemoglobin. There is a strong correlation between temperature and blood velocity (R= 81, p <0.001). After treatment with experimental drug (liposomal doxorubicin and interleukin-12), temperature, blood velocity, blood volume and deoxy-hemoglobin of the lesions are reduced from the baseline at week 18. The techniques are objective, easy to perform, and appear to be very sensitive in assessing improvement in the lesions upon administration of therapy.
authors.affiliation: Lab. of Integrative and Medical Biophysics, National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH), Bethesda, MD 20892, USA. Email: amir@helix.nih.gov.
authors.forename: Amir
authors.initials: A
authors.lastname: Gandjbakhche
authors.forename: Abby
authors.initials: A
authors.lastname: Vogel
authors.forename: Franck
authors.initials: F
authors.lastname: Amyot
authors.forename: Victor
authors.initials: V
authors.lastname: Chernomordik
authors.forename: Moinuddin
authors.initials: M
authors.lastname: Hassan
authors.forename: Stavros
authors.initials: S
authors.lastname: Demos
authors.forename: Karen
authors.initials: K
authors.lastname: Aleman
authors.forename: Richard
authors.initials: R
authors.lastname: Little
authors.forename: Robert
authors.initials: R
authors.lastname: Yarchoan