title: Severe photosensitivity causing multifocal squamous cell carcinomas secondary to prolonged voriconazole therapy.
abstract: A 32-year-old woman was treated with long-term voriconazole therapy for recurrent aspergillosis associated with chronic granulomatous disease. A short time after commencement of voriconazole therapy, a severe photosensitivity reaction developed. Continued voriconazole exposure led to the development of multifocal facial squamous cell carcinomas. The photosensitivity reaction resolved after the patient changed therapy to posaconazole.
authors.affiliation: Sullivan and Nicolaides Pathology, Princess Alexandra Hospital, Queensland, Australia. Kate_Mccarthy@snp.com.au
authors.forename: Kate L
authors.initials: KL
authors.lastname: McCarthy
authors.forename: E Geoffrey
authors.initials: EG
authors.lastname: Playford
authors.forename: David F M
authors.initials: DF
authors.lastname: Looke
authors.forename: Michael
authors.initials: M
authors.lastname: Whitby
mesh_terms: D000328:Adult; D000935:Antifungal Agents / Q000009:adverse effects* / Q000627:therapeutic use; D002294:Carcinoma, Squamous Cell / Q000209:etiology*; D005260:Female; D006105:Granulomatous Disease, Chronic / Q000188:drug therapy; D006801:Humans; D010787:Photosensitivity Disorders / Q000139:chemically induced* / Q000175:diagnosis / Q000473:pathology; D011743:Pyrimidines / Q000009:adverse effects* / Q000627:therapeutic use; D012878:Skin Neoplasms / Q000209:etiology*; D014230:Triazoles / Q000009:adverse effects* / Q000627:therapeutic use; D065819:Voriconazole
chemical_list: D000935:Antifungal Agents; D011743:Pyrimidines; D014230:Triazoles; D065819:Voriconazole