title: Endotracheal castleman disease: A case report.
abstract: Castleman disease (CD) is an uncommon benign lymphoid hyperplasia with several clinical and morphologic variants associated with distinct outcomes. Pulmonary CD has been reported as a rare extranodal manifestation in the literature. However, CD presenting as an obstructive mass in the airway has not been documented. We report a case of localized hyaline-vascular CD presenting as an endotracheal lesion. The patient was a 50-year-old woman with Marfan syndrome. The lesion caused near-complete airway obstruction with respiratory insufficiency. The patient underwent laser resection, and the diagnosis of CD was supported by comprehensive studies including histopathologic, immunohistochemical, and molecular methods.
authors.affiliation: Department of Pathology, School of Medicine, University of California, San Diego, La Jolla, CA, USA.
authors.forename: Truc T
authors.initials: TT
authors.lastname: Pham
authors.forename: James H
authors.initials: JH
authors.lastname: Harrell
authors.forename: James H
authors.initials: JH
authors.lastname: Harrell
authors.forename: Brian
authors.initials: B
authors.lastname: Herndier
authors.forename: Eunhee S
authors.initials: ES
authors.lastname: Yi
mesh_terms: D005871:Castleman Disease / Q000175:diagnosis* / Q000601:surgery; D005260:Female; D006801:Humans; D008875:Middle Aged; D014132:Trachea