title: Cognitive aging, executive function, and fractional anisotropy: a diffusion tensor MR imaging study.
abstract: OBJECTIVE
  Fractional anisotropy (FA) is a useful measure of connectivity in the brain that can be derived from the diffusion tensor imaging (DTI) dataset. This study investigated the relationship between FA and selected measures of cognition across a broad age group to explore a possible structural basis for cognitive changes with age.
  
  
  METHODS
  FA images were generated from DTI data acquired at 1.5T in 87 healthy subjects (age range, 20-73 years). Relationships between a range of cognitive measures and FA were explored using regional and voxel-based analysis.
  
  
  RESULTS
  Age and regional average FA were significantly associated in the frontal, parietal, and temporal lobes but not in the occipital lobe. This negative relationship was especially prominent in the prefrontal regions of the frontal lobe, where FA declined at a rate of approximately 3% per decade. Decreased FA in the frontal, temporal, and parietal lobes was associated with poorer cognitive performance in executive maze and in an attention-switching task. A voxel-level analysis of these data revealed that the executive function-FA association was particularly strong and regionally delineated over 2 continuous, bilateral areas extending from the prefrontal cortex to the parietal lobe, with projections to the anterior portions of the thalamus.
  
  
  CONCLUSIONS
  We demonstrate a relationship between FA and a measure of executive function-a core cognitive component that is a key feature of cognitive aging. We propose that that FA may provide an early means for the detection of age-related cognitive change and suggest a need for prospective data to explore this association.
authors.affiliation: The Brain Resource International Database, The Brain Resource Company, Ultimo, Australia. sgrieve@gmp.usyd.edu.au
authors.forename: S M
authors.initials: SM
authors.lastname: Grieve
authors.forename: L M
authors.initials: LM
authors.lastname: Williams
authors.forename: R H
authors.initials: RH
authors.lastname: Paul
authors.forename: C R
authors.initials: CR
authors.lastname: Clark
authors.forename: E
authors.initials: E
authors.lastname: Gordon
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging / Q000473:pathology*; D016880:Anisotropy; D002540:Cerebral Cortex / Q000473:pathology*; D003071:Cognition; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods; D005260:Female; D005625:Frontal Lobe / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009778:Occipital Lobe / Q000473:pathology; D010296:Parietal Lobe / Q000473:pathology; D011594:Psychometrics; D013702:Temporal Lobe / Q000473:pathology