title: Characteristics of a tertiary center enuresis population, with special emphasis on the relation among nocturnal diuresis, functional bladder capacity and desmopressin response.
abstract: OBJECTIVE
  We evaluated pretreatment values of circadian rhythm of urine production and urine osmolality in children with different subtypes of monosymptomatic nocturnal enuresis, and investigated their predictive value for desmopressin response.
  
  
  METHODS
  We assessed 125 consecutive patients with monosymptomatic nocturnal enuresis, nocturnal polyuria and normal functional bladder capacity who were treated with desmopressin for a median of 17 months (range 3 to 100). Patients were characterized according to the desmopressin response as full responders or nonfull responders. Baseline parameters were obtained from a 2-week home recording diary. Results were compared with 125 consecutive children with monosymptomatic nocturnal enuresis and reduced functional bladder capacity.
  
  
  RESULTS
  No differences in pretreatment values of functional bladder capacity, circadian rhythm of urine production or urine osmolality were found between desmopressin full responders and nonfull responders. Patients with nocturnal polyuria had a significantly higher 24-hour diuresis volume compared to children with reduced functional bladder capacity. Some children with reduced functional bladder capacity also had nocturnal polyuria.
  
  
  CONCLUSIONS
  Our findings show that the characteristics of nocturnal polyuria in patients with monosymptomatic nocturnal enuresis and normal functional bladder capacity do not predict desmopressin response. The wide overlap among the different subgroups suggests that dividing patients with monosymptomatic nocturnal enuresis into those with reduced functional bladder capacity and those with desmopressin responsive nocturnal polyuria might be insufficient. Patients with nocturnal polyuria and normal functional bladder capacity have a significantly higher daytime and nighttime diuresis volume compared to children with reduced functional bladder capacity, suggesting a direct correlation between daytime fluid intake and nocturnal diuresis rate. Some children with reduced functional bladder capacity also have nocturnal polyuria.
authors.affiliation: Department of Pediatric Nephrology and Urology, University Hospital Ghent, Ghent, Belgium.
authors.forename: J L C
authors.initials: JL
authors.lastname: Dehoorne
authors.forename: C Vande
authors.initials: CV
authors.lastname: Walle
authors.forename: P
authors.initials: P
authors.lastname: Vansintjan
authors.forename: A M
authors.initials: AM
authors.lastname: Raes
authors.forename: A R P
authors.initials: AR
authors.lastname: De Guchtenaere
authors.forename: E
authors.initials: E
authors.lastname: Van Laecke
authors.forename: P
authors.initials: P
authors.lastname: Hoebeke
authors.forename: J G J
authors.initials: JG
authors.lastname: Vande Walle
mesh_terms: D000293:Adolescent; D050034:Antidiuretic Agents / Q000627:therapeutic use*; D002648:Child; D002940:Circadian Rhythm / Q000502:physiology*; D015331:Cohort Studies; D003187:Compliance; D003894:Deamino Arginine Vasopressin / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D053206:Nocturnal Enuresis / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology*; D009994:Osmolar Concentration; D011141:Polyuria / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology; D011237:Predictive Value of Tests; D016896:Treatment Outcome; D001743:Urinary Bladder / Q000503:physiopathology*; D014556:Urine / Q000737:chemistry
chemical_list: D050034:Antidiuretic Agents; D003894:Deamino Arginine Vasopressin