title: Decreased levels of peritoneal interleukin-1 receptor antagonist in patients with endometriosis and disease-related dysmenorrhea.
abstract: OBJECTIVE
  To determine the level of interleukin-1 receptor antagonist (IL-1ra) in peritoneal fluid (PF) and serum in patients with endometriosis.
  
  
  METHODS
  A prospective analytical study.
  
  
  METHODS
  University-affiliated obstetrics and gynecology academic training hospital.
  
  
  METHODS
  One hundred eighteen patients underwent laparoscopy for benign gynecologic diseases.
  
  
  METHODS
  Peripheral blood and PF were obtained before and during surgical procedures, and the levels of IL-1ra were measured.
  
  
  METHODS
  The concentrations of IL-1ra in PF and serum were correlated with the presence of endometriosis, disease stage, and the phase of menstrual cycle.
  
  
  RESULTS
  Peritoneal fluid IL-1ra concentrations were significantly lower in patients with endometriosis than in patients without endometriosis. Peritoneal fluid IL-1ra concentrations decreased with the increased severity of endometriosis and also decreased in disease-related dysmenorrhea; serum IL-1ra levels showed no significant difference between the patients with and without endometriosis. The concentrations of IL-1ra in PF and serum were not correlated with the phase of menstrual cycle.
  
  
  CONCLUSIONS
  Our results suggested that decreased levels of PF IL-1ra in patients with endometriosis and disease-related dysmenorrhea may play an important role in the pathogenesis of this disease.
authors.affiliation: Women's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, People's Republic of China.
authors.forename: Xinmei
authors.initials: X
authors.lastname: Zhang
authors.forename: Jie
authors.initials: J
authors.lastname: Wen
authors.forename: Lin
authors.initials: L
authors.lastname: Deng
authors.forename: Jun
authors.initials: J
authors.lastname: Lin
mesh_terms: D000022:Abortion, Spontaneous / Q000453:epidemiology; D000328:Adult; D004412:Dysmenorrhea / Q000473:pathology*; D004715:Endometriosis / Q000473:pathology*; D005260:Female; D006801:Humans; D053590:Interleukin 1 Receptor Antagonist Protein / Q000378:metabolism*; D053583:Interleukin-1beta / Q000378:metabolism; D011247:Pregnancy; D013246:Sterilization, Tubal
chemical_list: C507763:IL1RN protein, human; D053590:Interleukin 1 Receptor Antagonist Protein; D053583:Interleukin-1beta