[Perspectives for development of polyvalent meningococcal vaccine].
Experimental whole-culture oral polyvalent meningococcal vaccines against serogroups A, B and C consisting of three monovalent components in different proportions have been developed and evaluated. Kinetics of IgG response to meningococcal antigens (outer membrane proteins, polysaccharide, lypooligosaccharide of these serogroups) in sera of rabbits immunized orally with these preparations was measured. Sharp rise of IgG levels (on 2 - 3 orders) compared to baseline has been detected as well as persistence of high titers during the observation period (322 days).
Basnak'ian
I A
IA
Aleksakhina
N N
NN
D000284:Administration, Oral; D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood; D001426:Bacterial Proteins / Q000276:immunology; D004353:Drug Evaluation, Preclinical; D007124:Immunoenzyme Techniques; D007074:Immunoglobulin G / Q000097:blood; D008589:Meningococcal Infections / Q000276:immunology*; D022401:Meningococcal Vaccines / Q000008:administration & dosage / Q000737:chemistry / Q000276:immunology*; D009345:Neisseria meningitidis / Q000276:immunology*; D011135:Polysaccharides, Bacterial / Q000276:immunology; D011817:Rabbits; D014611:Vaccination
D000907:Antibodies, Bacterial; D001426:Bacterial Proteins; D007074:Immunoglobulin G; D022401:Meningococcal Vaccines; D011135:Polysaccharides, Bacterial