Baicalein improves cognitive deficits induced by chronic cerebral hypoperfusion in rats.
The aim of this study is to investigate the effects of baicalein on cognitive impairment and neuronal degeneration in a rat model of chronic cerebral hypoperfusion induced by permanent occlusion of bilateral common carotid arteries (2VO). It was found that baicalein (2 or 4 mg/kg/day, i.p.) significantly improved 2VO-induced cognitive deficits and neuropathological changes. Biochemical and histological examinations revealed that baicalein reduced the increased activities of superoxide dismutase (SOD) and malondialdehyde (MDA), and attenuated the decreased activities of glutathione peroxidase (GPx) and catalase in 2VO rats. The results of the present observation suggest that baicalein has therapeutic potential for the treatment of vascular dementia, which is most likely related, at least in part, to its antioxidant action.
Liu
Chao
C
Department of Pharmacology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China.
Wu
Jiliang
J
Gu
Jun
J
Xiong
Zhe
Z
Wang
Fang
F
Wang
Jianzhi
J
Wang
Wei
W
Chen
Jianguo
J
D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000627:therapeutic use*; D001921:Brain / Q000187:drug effects / Q000473:pathology; D002545:Brain Ischemia / Q000150:complications / Q000378:metabolism / Q000523:psychology; D017536:Carotid Artery, Common; D002374:Catalase / Q000378:metabolism; D003072:Cognition Disorders / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism / Q000523:psychology; D003250:Constriction; D015140:Dementia, Vascular / Q000188:drug therapy / Q000378:metabolism / Q000523:psychology; D004195:Disease Models, Animal; D044950:Flavanones / Q000008:administration & dosage / Q000627:therapeutic use*; D005979:Glutathione Peroxidase / Q000378:metabolism; D006801:Humans; D008315:Malondialdehyde / Q000378:metabolism; D018782:Maze Learning / Q000187:drug effects; D009474:Neurons / Q000187:drug effects / Q000473:pathology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013482:Superoxide Dismutase / Q000378:metabolism
D000975:Antioxidants; D044950:Flavanones; C006680:baicalein; D008315:Malondialdehyde; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase