[Immunologic autoagression in patients with diabetic retinopathy under type I diabetes mellitus].
Presence of IgG autoantibodies to broad spectrum of tissues' antigens in patients with diabetic retinopathy under type I diabetes mellitus was studied. Increased levels of antibodies to different antigens were observed in 56% of patients. Increased levels of antibodies to hypophysis, denaturated DNA, and myelin basic protein were detected most frequently. Correlation in presence of autoantibodies of different specificity with diabetes length as well as with frequency of respiratory infections was established. There was relation between level of antibodies to DNA and increased permeability of microvascular network of retina as well as between presence of autoantibodies to myelin basic protein and encephalopathy in patients with type I diabetes mellitus.
Teplinskaia
L E
LE
Iastrebova
N E
NE
Vetrov
Iu D
IuD
Vaneeva
N P
NP
D001323:Autoantibodies / Q000097:blood*; D002199:Capillary Permeability; D004247:DNA / Q000276:immunology; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000175:diagnosis / Q000276:immunology*; D003930:Diabetic Retinopathy / Q000209:etiology* / Q000276:immunology; D018450:Disease Progression; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D009186:Myelin Sheath / Q000276:immunology; D010902:Pituitary Gland / Q000276:immunology; D012141:Respiratory Tract Infections / Q000150:complications; D012171:Retinal Vessels / Q000473:pathology
D001323:Autoantibodies; D007074:Immunoglobulin G; D004247:DNA