A convenient new procedure for converting primary amides into nitriles.
An operationally simple and high-yielding procedure has been developed for the conversion of primary amides to the corresponding nitriles, using ethyl dichlorophosphate/DBU as the mild dehydrating agent.
Kuo
Chun-Wei
CW
Division of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli County, 350, Taiwan, R.O.C.
Zhu
Jia-Liang
JL
Wu
Jen-Dar
JD
Chu
Cheng-Ming
CM
Yao
Ching-Fa
CF
Shia
Kak-Shan
KS
D000577:Amides / Q000737:chemistry*; D015394:Molecular Structure; D009570:Nitriles / Q000737:chemistry*; D014867:Water / Q000737:chemistry
D000577:Amides; D009570:Nitriles; D014867:Water