Theory and Experiments of MEMS Thermal Biosensors.
This paper presents a theoretical and experimental investigation of MEMS thermal biosensors in flow-through measurements of metabolites. A model is developed to consider convective heat transfer effects and enzyme kinetics using the Michaelis-Menton theory. Numerical solutions from the model are compared with experimental data obtained from a prototype MEMS thermal biosensor. Satisfactory agreement is found between the theoretical and experimental results, indicating that the model is useful for designing MEMS thermal biosensors with optimized performance.
Wang
Li
L
Mechanical Engineering Department, Carnegie Mellon University, 5000 Forbes Ave., Pittsburgh, PA 15213 USA (phone: 412-2682514;e-mail: liw@andrew.cmu.edu).
Lin
Qiao
Q