A Simulation Study of Firing Patterns based on Coupling Effect between Soma and Dendrite.
The aim of this study is to investigate how firing patterns of neuron in hippocampus change with coupling effect between soma and dendrite via simulation of single neuron firings by a two-compartment (soma-dendrite) model. The results will help to understand how firing patterns relative to synaptic plasticity in further study. The neuron model used in this study consisted two compartments: the soma compartment and the dendrite compartment, which can describe synaptic input functions. Simulations of neural firings were performed with fourth order Runge-Kutta algorithm with different range of coupling conductance. Firing patterns of neuron were simulated under different current applied to soma (Is). The range for different firing patterns is: Is=0..A/cm2, range for spiking is [0.0, 1.8] and [4.5, ..], for bursting is [1.9,4.4]; Is=0.5..A/cm2, range for spiking is [0.0, 2.2] and [4.0, ..], for bursting is [2.3,3.9]; Is=1.0..A/cm2, range for spiking is [0.0, 2.5] and [3.6, ..], for bursting is [2.6,3.5]; Is=1.5..A/cm2, range for spiking is [0.0, 2.5] and [3.8, ..], for bursting is [2.6,3.7]; Is=2.0..A/cm2, range for spiking is [0.0, 2.6] and [3.6, ..], for bursting is [2.7,3.5]; Is=2.5..A/cm2, range for spiking is [0.0, 2.6] and [3.3, ..], for bursting is [2.7,3.2].
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Department of Biomedical Engineering, Tianjin Medical University, Tianjin, China, 300070.
Tian
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