Copper-catalyzed addition of H-phosphine oxides to alkynes forming alkenylphosphine oxides.
We have developed efficient copper-catalyzed additions of P(O)H compounds to alkynes, and the reactions provided the regio- and stereoselective E-alkenylphosphine oxides under catalysis of the commercially available and inexpensive copper catalyst system CuI/ethylenediamine. This finding is the first example of copper-catalyzed hydrophosphinylation of alkynes to synthesize alkenylphosphine oxides.
Niu
Mingyu
M
Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology, Ministry of Education, Department of Chemistry, Tsinghua University, Beijing, 100084, P. R. China.
Fu
Hua
H
Jiang
Yuyang
Y
Zhao
Yufen
Y
D000114:Acetylene / Q000031:analogs & derivatives / Q000737:chemistry; D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D006859:Hydrogen / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010087:Oxides / Q000737:chemistry*; D010720:Phosphines / Q000737:chemistry*
D000480:Alkynes; D010087:Oxides; D010720:Phosphines; C044736:phenylacetylene; D003300:Copper; D006859:Hydrogen; C044646:phosphine; D000114:Acetylene