Representing intestinal drug transport in silico: an agent-oriented approach.
A prototype Epithelio-Mimetic Device (EMD) was developed and tested. EMD components are designed to map logically to biological components at multiple levels of resolution. Those components are engineered to represent actual components within an in vitro cellular system used to study intestinal drug transport. Our goal is that the behaviors of the EMD closely match observed behaviors of the in vitro systems for a wide variety of drugs. Early stage system verification is achieved. The general patterns of experimental results from the EMD for a set of hypothetical drugs having a variety of physicochemical properties reasonably match observed patterns for a wide range of experimental conditions.
Liu
Yu
Y
UCSF/UCB Joint Graduate Group in Bioengineering, California Univ., Berkeley, CA, USA.
Hunt
C Anthony
CA