Titanium- and Lewis acid-mediated cyclopropanation of imides.
We report a straightforward synthesis of 1-azaspirocyclopropane lactams from imides. Following the described procedure, polycyclic nitrogen heterocycles containing a cyclopropane unit could be obtained from unsaturated imides. [reaction: see text].
Bertus
Philippe
P
UMR 6519, Réactions Sélectives et Applications, CNRS, Université de Reims Champagne-Ardenne, BP 1039, 51687 REIMS Cedex 2, France. philippe.bertus@univ-reims.fr
Szymoniak
Jan
J