title: Major hepatectomy in patients with synchronous colorectal liver metastases: whether or not a contraindication to simultaneous colorectal and liver resection?
abstract: OBJECTIVE
  Synchronous hepatic lesions account for 15-25% of newly diagnosed colorectal cancer and its optimal timing to surgery is not completely defined, but simultaneous colorectal and liver resection is recently gaining acceptance, at least in patients with a right colonic primary and liver metastases that need a minor hepatectomy to be fully resected.
  
  
  METHODS
  From September 2002 to December 2004, 16 patients underwent simultaneous resection as treatment of synchronous colorectal liver resection; in 10 patients (62.5%) a major hepatectomy was performed.
  
  
  RESULTS
  The mean duration of intervention was 322.5 +/- 59.5 min, operative mortality and morbidity rates was 0% and 25% respectively; the hospitalization was 14.4 (range 8-60) days on average. Mean follow-up was 14 months and actuarial survival was 76.5% at 1 year and 63.5% at 2 years.
  
  
  CONCLUSIONS
  We concluded that simultaneous colonic and liver resection should be undertaken in selected patients with synchronous colorectal liver resection regardless of the extent of hepatectomy; major liver resection, in fact, seems capable of providing better oncological results, allowing resection of liver micrometastases that, in almost one-third of the patients, are located in the same liver lobe of macroscopic lesions, without increased morbidity rates.
authors.affiliation: Surgical Department, Maggiore Hospital, Bologna, Italy. Elio.Jovine@ausl.bologna.it
authors.forename: E
authors.initials: E
authors.lastname: Jovine
authors.forename: F
authors.initials: F
authors.lastname: Biolchini
authors.forename: F
authors.initials: F
authors.lastname: Talarico
authors.forename: F M
authors.initials: FM
authors.lastname: Lerro
authors.forename: L
authors.initials: L
authors.lastname: Mastrangelo
authors.forename: S
authors.initials: S
authors.lastname: Selleri
authors.forename: G
authors.initials: G
authors.lastname: Landolfo
authors.forename: F
authors.initials: F
authors.lastname: Martuzzi
authors.forename: D R
authors.initials: DR
authors.lastname: Iusco
authors.forename: A
authors.initials: A
authors.lastname: Lazzari
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003082:Colectomy / Q000706:statistics & numerical data; D015179:Colorectal Neoplasms / Q000401:mortality / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006498:Hepatectomy / Q000706:statistics & numerical data*; D006801:Humans; D007902:Length of Stay; D008113:Liver Neoplasms / Q000401:mortality / Q000556:secondary* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis / Q000000981:diagnostic imaging; D012189:Retrospective Studies; D013997:Time Factors; D016896:Treatment Outcome; D014463:Ultrasonography