title: Primitive neuroectodermal tumor of the central nervous system with glial differentiation: a FISH study of an adult case.
abstract: Primitive neuroectodermal tumors (PNETs) of the central nervous system (CNS), a rare occurrence in adults, may show glial differentiation and can be misinterpreted as pure astrocytic neoplasms. Few fluorescence in situ hybridization (FISH) studies have been carried out on these tumors; isochromosome 17q was found to be the major chromosomal abnormality. We present the case of an adult in which we performed a FISH study of both the glial and neuronal components. A complex array of FISH changes, not including an isochromosome 17q were identified.
authors.affiliation: Department of Pathology, Hospital del Mar, Passeig Maritim 25-29, 08003 Barcelona, Spain. 86780@imas.imim.es
authors.forename: F
authors.initials: F
authors.lastname: Alameda
authors.forename: J
authors.initials: J
authors.lastname: Lloreta
authors.forename: A
authors.initials: A
authors.lastname: Ariza
authors.forename: M
authors.initials: M
authors.lastname: Salido
authors.forename: B
authors.initials: B
authors.lastname: Espinet
authors.forename: T
authors.initials: T
authors.lastname: Baro
authors.forename: G
authors.initials: G
authors.lastname: Garcia-Fructoso
authors.forename: E
authors.initials: E
authors.lastname: Galito
authors.forename: A
authors.initials: A
authors.lastname: Munne
authors.forename: F F
authors.initials: FF
authors.lastname: Cruz Sanchez
authors.forename: F
authors.initials: F
authors.lastname: Sole
authors.forename: S
authors.initials: S
authors.lastname: Serrano
mesh_terms: D000328:Adult; D001932:Brain Neoplasms / Q000235:genetics* / Q000473:pathology*; D002886:Chromosomes, Human, Pair 17 / Q000235:genetics*; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D018242:Neuroectodermal Tumors, Primitive / Q000235:genetics* / Q000473:pathology*; D014314:Trisomy / Q000235:genetics*