Primitive neuroectodermal tumor of the central nervous system with glial differentiation: a FISH study of an adult case.
Primitive neuroectodermal tumors (PNETs) of the central nervous system (CNS), a rare occurrence in adults, may show glial differentiation and can be misinterpreted as pure astrocytic neoplasms. Few fluorescence in situ hybridization (FISH) studies have been carried out on these tumors; isochromosome 17q was found to be the major chromosomal abnormality. We present the case of an adult in which we performed a FISH study of both the glial and neuronal components. A complex array of FISH changes, not including an isochromosome 17q were identified.
Alameda
F
F
Department of Pathology, Hospital del Mar, Passeig Maritim 25-29, 08003 Barcelona, Spain. 86780@imas.imim.es
Lloreta
J
J
Ariza
A
A
Salido
M
M
Espinet
B
B
Baro
T
T
Garcia-Fructoso
G
G
Galito
E
E
Munne
A
A
Cruz Sanchez
F F
FF
Sole
F
F
Serrano
S
S
D000328:Adult; D001932:Brain Neoplasms / Q000235:genetics* / Q000473:pathology*; D002886:Chromosomes, Human, Pair 17 / Q000235:genetics*; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D018242:Neuroectodermal Tumors, Primitive / Q000235:genetics* / Q000473:pathology*; D014314:Trisomy / Q000235:genetics*