title: Vocal fold augmentation with calcium hydroxylapatite (CaHA).
abstract: OBJECTIVE
  Evaluate the effectiveness of CaHA injection for patients with glottal incompetence.
  
  
  METHODS
  Multi-center, open-label, prospective clinical study with each patient serving as his/her own control. Voice-related outcome measures were collected for pre-injection and 1, 3, and 6 months.
  
  
  RESULTS
  Sixty-eight patients were available for evaluation. Fifty percent of the injection procedures were done in office. Fifty-seven percent were diagnosed with unilateral paralysis and 42% with glottal incompetence with mobile vocal folds. Patient satisfaction 6 months post showed 56% had significantly improved voice and 38% reported moderately improved voice. Paired t tests from baseline to 6 months showed significant improvements on the VHI and VAS (vocal effort), CAPE-V judgments of voice severity and videoendostroboscopy ratings of glottal closure, and objective voice measures of glottal closure (MPT and S:Z ratio).
  
  
  CONCLUSIONS
  Preliminary results in this large cohort of patients demonstrate excellent clinical results.
authors.affiliation: University of Pittsburgh Dept. of Otolaryngology-HNS, University of Pittsburgh Voice Center, Pittsburgh, PA 15213, USA, and University Hospital of Louvain-Mont Goddine, Yvoir, Belgium. RosenCA@upmc.edu
authors.forename: Clark A
authors.initials: CA
authors.lastname: Rosen
authors.forename: Jackie
authors.initials: J
authors.lastname: Gartner-Schmidt
authors.forename: Roy
authors.initials: R
authors.lastname: Casiano
authors.forename: Timothy D
authors.initials: TD
authors.lastname: Anderson
authors.forename: Felicia
authors.initials: F
authors.lastname: Johnson
authors.forename: Lee
authors.initials: L
authors.lastname: Reussner
authors.forename: Marc
authors.initials: M
authors.lastname: Remacle
authors.forename: Robert T
authors.initials: RT
authors.lastname: Sataloff
authors.forename: Jean
authors.initials: J
authors.lastname: Abitbol
authors.forename: Gary
authors.initials: G
authors.lastname: Shaw
authors.forename: Sanford
authors.initials: S
authors.lastname: Archer
authors.forename: Andrew
authors.initials: A
authors.lastname: McWhorter
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001672:Biocompatible Materials / Q000008:administration & dosage / Q000627:therapeutic use*; D017886:Durapatite / Q000008:administration & dosage / Q000627:therapeutic use*; D005931:Glottis; D006801:Humans; D007267:Injections; D008875:Middle Aged; D011446:Prospective Studies; D049489:Stroboscopy; D014826:Vocal Cord Paralysis / Q000628:therapy*; D014827:Vocal Cords
chemical_list: D001672:Biocompatible Materials; D017886:Durapatite