Transient ischemic dilation ratio (TID) correlates with HbA(1c) in patients with diabetes type 2 with proven myocardial ischemia according to exercise myocardial SPECT.
OBJECTIVE
Abnormal values of the transient ischemic dilation ratio (TID) according to an exercise myocardial SPECT are linked to severe coronary artery disease. The authors investigated the relationship between TID and the levels of VCAM, ICAM, E-selectin, microalbuminuria, intima-media thickness and HbA(1c) of diabetic subjects.


METHODS
We observed 38 subjects with diabetes type 2 (10 women, 28 men), of average age 56.08 +/- 8.24 years, with no past history of cardiovascular disease. All subjects were examined using an exercise myocardial SPECT. Transient ischemic dilation, summed stress score (SSS), summed rest score (SRS) and stress total severity score (STSS) were determined to quantify myocardial ischemia.


RESULTS
The average IMT value was 1.05 +/- 0.31 mm. The TID value was 1.02 +/- 0.154, VCAM 795.24 +/- 163.25 mg/l, ICAM 516.55 +/- 164.07, E-selectin 63.82 +/- 38.89, HbA(1c) 7.09 +/- 1.68%, microalbuminuria 68.01 +/- 55.21 mg/l. When ascertaining the relation of TID to the other factors we used Pearson's correlation at the level of significance p < 0.05. We proved a statistically significant correlation between the value of TID and glycosylated hemoglobin HbA(1c) (p = 0.035); the other factors did not show any significant correlation.


CONCLUSIONS
Diabetes and its long- term unsatisfactory compensation can be one of the factors which affect left ventricular transient ischemic dilation.
Adamikova
Alena
A
Diabetes Center, WHO Collaborating Center for the Study of Diabetes, Bata Regional Hospital, Zlín, Czech Republic. adamikova@bnzlin.cz
Bakala
Jiri
J
Bernatek
Jaromir
J
Rybka
Jaroslav
J
Svacina
Stepan
S
D000368:Aged; D017023:Coronary Angiography / Q000379:methods; D003324:Coronary Artery Disease / Q000175:diagnosis / Q000473:pathology; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000473:pathology; D015444:Exercise; D005260:Female; D006442:Glycated Hemoglobin / Q000096:biosynthesis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015233:Models, Statistical; D017202:Myocardial Ischemia / Q000150:complications* / Q000473:pathology; D012044:Regression Analysis; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*; D018487:Ventricular Dysfunction, Left
D006442:Glycated Hemoglobin