title: [Cogan's syndrome: ocular findings in an atypical case].
abstract: Cogan's syndrome is an unusual multisystemic disease characterized by interstitial keratitis in association with vestibuloauditory dysfunction and possible irreversible deafness, classified into 2 clinical types: typical and atypical. There is disagreement in the literature about corneal disease in the atypical variety. A 32-year-old woman complaining of ocular hyperemia and ocular pain, photophobia and visual acuity loss in the right eye associated with sudden left hearing loss, vomiting, diarrhea, oliguria, oropharynx pain and fever. Previous history of similar disease in left eye and right hearing. There was intense conjunctival hyperemia, nodular scleritis, episcleritis, and circular infiltrates in the corneal stroma. The patient received pulse-therapy with methylprednisolone and cyclophosphamide. She exhibited significant ocular improvement but poor hearing results. The reported case may be a typical Cogan's syndrome (according to authors that assert the non-existence of corneal disease in the atypical type) with some findings characteristic of the atypical type or an atypical Cogan's syndrome (for those asserting that it is a corneal disease). Differential diagnosis is also discussed.
authors.affiliation: Universidade Federal do Rio Grande do Norte, Natal, RN, Brasil.
authors.forename: Ana Karina Santiago de Medeiros
authors.initials: AK
authors.lastname: Lima
authors.forename: Carlos Alexandre de Amorim
authors.initials: CA
authors.lastname: Garcia
authors.forename: Marco Antônio Rey de
authors.initials: MA
authors.lastname: Faria
authors.forename: Uchoandro Bezerra Costa
authors.initials: UB
authors.lastname: Uchoa
mesh_terms: D000328:Adult; D003520:Cyclophosphamide / Q000627:therapeutic use; D003937:Diagnosis, Differential; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D034381:Hearing Loss / Q000175:diagnosis* / Q000188:drug therapy; D006801:Humans; D006940:Hyperemia / Q000175:diagnosis; D007634:Keratitis / Q000175:diagnosis* / Q000188:drug therapy; D008575:Meniere Disease / Q000175:diagnosis*; D011241:Prednisone / Q000627:therapeutic use; D013577:Syndrome
chemical_list: D005938:Glucocorticoids; D003520:Cyclophosphamide; D011241:Prednisone