title: Estimation of influence of gastric emptying on shape of glucose concentration-time profile measured in oral glucose tolerance test.
abstract: OBJECTIVE
  To develop a model for simulations of processes in the oral glucose tolerance test (OGTT), using tools of the theory of dynamic systems.
  
  
  METHODS
  Frequent sampling OGTT was performed in 13 healthy subjects (6 males and 7 females). Subsequently, employing glucose and insulin concentration-time profiles of the subjects, the model was developed.
  
  
  RESULTS
  In all subjects the model was able to simulate influences of the insulin plasma concentration and gastric emptying rate on glucose concentration and to determine time profiles of glucose fractions retained in stomach.
  
  
  CONCLUSIONS
  The approach presented represents an opportunity for building models for data analyses in OGTT.
authors.affiliation: Faculty of Mechanical Engineering, Slovak University of Technology, Slobody 17, 812 31 Bratislava, Slovak Republic. ladislav.dedik@stuba.sk
authors.forename: Ladislav
authors.initials: L
authors.lastname: Dedík
authors.forename: Mária
authors.initials: M
authors.lastname: Durisová
authors.forename: Adela
authors.initials: A
authors.lastname: Penesová
authors.forename: Daniela
authors.initials: D
authors.lastname: Miklovicová
authors.forename: Martina
authors.initials: M
authors.lastname: Tvrdonová
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000032:analysis*; D005260:Female; D005746:Gastric Emptying; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood; D007700:Kinetics; D008297:Male; D008954:Models, Biological; D008962:Models, Theoretical
chemical_list: D001786:Blood Glucose; D007328:Insulin