title: Apolipoprotein E gene polymorphism and left ventricular function in Iranian patients with thalassemia major.
abstract: Left ventricular (LV) failure is the main cause of death in thalassemia. Iron overload in patients with thalassemia leads to the formation of oxygen free radicals. Of the various apolipoprotein E (apoE) alleles, apoE4 is the least efficient in conditions of oxidative stress in comparison with apoE2 and apoE3. Our results showed that apoE4 is a genetic risk factor for LV dysfunction in thalassemia.
authors.forename: Masood
authors.initials: M
authors.lastname: Bazrgar
authors.forename: Mehran
authors.initials: M
authors.lastname: Karimi
authors.forename: Farah
authors.initials: F
authors.lastname: Peiravian
authors.forename: Mohsen
authors.initials: M
authors.lastname: Fathzadeh
mesh_terms: D000293:Adolescent; D000328:Adult; D053329:Apolipoprotein E2 / Q000235:genetics; D053318:Apolipoprotein E3 / Q000235:genetics; D053327:Apolipoprotein E4 / Q000235:genetics; D001057:Apolipoproteins E / Q000235:genetics*; D002648:Child; D005260:Female; D006801:Humans; D007492:Iran; D008297:Male; D011110:Polymorphism, Genetic; D012307:Risk Factors; D018487:Ventricular Dysfunction, Left / Q000175:diagnosis / Q000235:genetics*; D017086:beta-Thalassemia / Q000235:genetics*
chemical_list: D053329:Apolipoprotein E2; D053318:Apolipoprotein E3; D053327:Apolipoprotein E4; D001057:Apolipoproteins E