Epithelioid and epithelial neoplasms of bone.
BACKGROUND
Epithelioid and epithelial neoplasms seen in bone are rare and include epithelioid variants of vascular lesions, osteoblastoma, osteosarcoma, chordoma, and chondroblastoma as well as adamantinoma and metastatic carcinoma.


OBJECTIVE
To provide an overview of tumors with epithelioid histology and address the clinical context and diagnostic issues.


METHODS
Pertinent literature is reviewed with emphasis on recent and controversial issues.


CONCLUSIONS
The differential diagnosis in epithelioid/epithelial lesions of bone is limited. The primary consideration in many cases is distinguishing primary from metastatic lesions.
Deyrup
Andrea T
AT
Department of Pathology, Emory University, Atlanta, GA, USA. adeyrup@emory.edu
Montag
Anthony G
AG
D014408:Biomarkers, Tumor / Q000032:analysis; D001859:Bone Neoplasms / Q000378:metabolism / Q000473:pathology*; D003937:Diagnosis, Differential; D006801:Humans; D007150:Immunohistochemistry; D009362:Neoplasm Metastasis / Q000473:pathology; D009375:Neoplasms, Glandular and Epithelial / Q000378:metabolism / Q000473:pathology*
D014408:Biomarkers, Tumor