Epstein-Barr virus early-antigen antibodies before allogeneic haematopoietic stem cell transplantation as a marker of risk of post-transplant lymphoproliferative disorders.
The occurrence of post-transplant lymphoproliferative disorders (PTLDs) after allogeneic haematopoietic stem cell transplantation (allo-HSCT) represents a clinical problem. Pretransplant Epstein-Barr virus serological status and viral load was determined in 21 recipients and 28 control transplanted patients, with (+) and without (-) PTLD, respectively. Early-antigen immunoglobulin G (EA-IgG) was detected in 12/21 PTLD+ patients, but only 2/28 PTLD patients (P = 0.00023, Odds ratio = 17.42). High viral load was detected in peripheral blood mononuclear cells at PTLD diagnosis, independently of deleted LMP1. Detection of EA-IgG in allo-HSCT recipients pretransplantation might be considered as risk factor for PTLD development.
Agbalika
Felix
F
Department of Microbiology, Saint-Louis Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France.
Larghero
Jerome
J
Esperou
Helene
H
Marais
Dominique
D
Robin
Marie
M
Foïs
Elena
E
de Latour
Régis Peffault
RP
Gluckman
Eliane
E
Rocha
Vanderson
V
Benbunan
Marc
M
Socié
Gerard
G
Marolleau
Jean-Pierre
JP
D000293:Adolescent; D000328:Adult; D000741:Anemia, Aplastic / Q000601:surgery / Q000821:virology; D000914:Antibodies, Viral / Q000097:blood*; D000956:Antigens, Viral / Q000276:immunology*; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D002452:Cell Count; D002648:Child; D002675:Child, Preschool; D020031:Epstein-Barr Virus Infections / Q000175:diagnosis*; D005199:Fanconi Anemia / Q000601:surgery / Q000821:virology; D005260:Female; D005434:Flow Cytometry; D018380:Hematopoietic Stem Cell Transplantation; D004854:Herpesvirus 4, Human; D006801:Humans; D007938:Leukemia / Q000601:surgery / Q000821:virology; D008232:Lymphoproliferative Disorders / Q000209:etiology* / Q000821:virology; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000601:surgery / Q000821:virology; D016017:Odds Ratio; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D012698:Serologic Tests; D014184:Transplantation, Homologous; D019562:Viral Load
D000914:Antibodies, Viral; D000956:Antigens, Viral; D015415:Biomarkers; C033305:Epstein-Barr virus early antigen