title: Brain networks underlining verbal fluency decline during STN-DBS in Parkinson's disease: an ECD-SPECT study.
abstract: We prospectively evaluated 20 patients with Parkinson's disease (PD) preoperatively and 12 months after subthalamic nucleus-deep brain stimulation (STN-DBS). All patients had clinical (UPDRS III) and neuropsychological evaluations as well as brain perfusion SPECT-ECD. Clinical and cognitive data were compared with 12 matched PD patients who had not undergone surgery. STN-DBS patients improved in motor symptoms and reduced medications but selectively declined in category fluency (p<0.01). No clinical and cognitive changes were found in the control group at follow-up. Worsening fluency was associated with perfusion decrements in left dorsolateral prefrontal cortex, anterior cingulate cortex and ventral caudate nucleus (p<.001).
authors.affiliation: Parkinson Institute, Istituti Clinici di Perfezionamento, Via Bignami 1, 20126, Milan, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Cilia
authors.forename: Chiara
authors.initials: C
authors.lastname: Siri
authors.forename: Giorgio
authors.initials: G
authors.lastname: Marotta
authors.forename: Danilo
authors.initials: D
authors.lastname: De Gaspari
authors.forename: Andrea
authors.initials: A
authors.lastname: Landi
authors.forename: Claudio B
authors.initials: CB
authors.lastname: Mariani
authors.forename: Riccardo
authors.initials: R
authors.lastname: Benti
authors.forename: Ioannis U
authors.initials: IU
authors.lastname: Isaias
authors.forename: Francesco
authors.initials: F
authors.lastname: Vergani
authors.forename: Gianni
authors.initials: G
authors.lastname: Pezzoli
authors.forename: Angelo
authors.initials: A
authors.lastname: Antonini
mesh_terms: D000368:Aged; D000704:Analysis of Variance; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology; D046690:Deep Brain Stimulation / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009415:Nerve Net / Q000000981:diagnostic imaging* / Q000473:pathology; D009942:Organometallic Compounds / Q000493:pharmacokinetics; D010300:Parkinson Disease / Q000473:pathology* / Q000628:therapy*; D011446:Prospective Studies; D020531:Subthalamic Nucleus / Q000503:physiopathology*; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D009942:Organometallic Compounds; C112051:technetium Tc 99m diaminedithiol