title: Best leads in the standard electrocardiogram for the emergency detection of acute coronary syndrome.
abstract: OBJECTIVE
  The purpose of this study was to determine which leads in the standard 12-lead electrocardiogram (ECG) are the best for detecting acute coronary syndrome (ACS) among chest pain patients in the emergency department.
  
  
  METHODS
  Neural network classifiers were used to determine the predictive capability of individual leads and combinations of leads from 862 ECGs from chest pain patients in the emergency department at Lund University Hospital.
  
  
  RESULTS
  The best individual lead was aVL, with an area under the receiver operating characteristic curve of 75.5%. The best 3-lead combination was III, aVL, and V2, with a receiver operating characteristic area of 82.0%, compared with the 12-lead ECG performance of 80.5%.
  
  
  CONCLUSIONS
  Our results indicate that leads III, aVL, and V2 are sufficient for computerized prediction of ACS. The present results are likely important in situations where the 12-lead ECG is impractical and for the creation of clinical decision support systems for ECG prediction of ACS.
authors.affiliation: Department of Theoretical Physics, Lund University, Lund, Sweden. michael@thep.lu.se
authors.forename: Michael
authors.initials: M
authors.lastname: Green
authors.forename: Mattias
authors.initials: M
authors.lastname: Ohlsson
authors.forename: Jakob Lundager
authors.initials: JL
authors.lastname: Forberg
authors.forename: Jonas
authors.initials: J
authors.lastname: Björk
authors.forename: Lars
authors.initials: L
authors.lastname: Edenbrandt
authors.forename: Ulf
authors.initials: U
authors.lastname: Ekelund
mesh_terms: D000368:Aged; D000789:Angina, Unstable / Q000175:diagnosis*; D001185:Artificial Intelligence; D003936:Diagnosis, Computer-Assisted / Q000379:methods*; D004562:Electrocardiography / Q000379:methods* / Q000592:standards; D004632:Emergency Medical Services / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis*; D011785:Quality Assurance, Health Care / Q000379:methods*; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D013577:Syndrome