Tetrahydrothiophene-catalyzed synthesis of benzo[n.1.0] bicycloalkanes.
A catalytic intramolecular cyclopropanation for the preparation of benzobicyclic compounds with [n.1.0] units has been developed. In the presence of 20 mol % of tetrahydrothiophene, the reactions of compounds 2a-2h afford versatile benzo[n.1.0]bicycloalkanes with excellent stereoselectivity in moderate to good isolated yields.
Ye
Long-Wu
LW
State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, P. R. China.
Sun
Xiu-Li
XL
Li
Chuan-Ying
CY
Tang
Yong
Y