MicroRNAs in normal and cancer cells: a new class of gene expression regulators.
MicroRNAs (miRNAs) are small non-coding RNAs that negatively regulate gene expression at posttranscriptional level. They are involved in cellular development, differentiation, proliferation and apoptosis and play a significant role in cancer. This review describes miRNA biogenesis, their functions in normal cells, and alterations of miRNA sets in cancer and roles of antitumorigenic and oncogenic miRNAs in cancer development.
Bagnyukova
T V
TV
Department of Biochemistry, Precarpathian National University, Ivano-Frankivsk 76025, Ukraine.
Pogribny
I P
IP
Chekhun
V F
VF
D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D005786:Gene Expression Regulation / Q000502:physiology*; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D035683:MicroRNAs / Q000502:physiology*; D009369:Neoplasms / Q000235:genetics*; D009857:Oncogenes / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*
D035683:MicroRNAs