title: Synthesis of novel diaryl ethers and their evaluation as antimitotic agents.
abstract: A series of novel diaryl ethers possessing various functional groups were synthesized and evaluated for antiproliferative activity in human myeloid leukemia HL-60 cells. Among the compounds examined, compounds 10, 17, 20, 24, and 33 showed moderate to potent antiproliferative activity. These derivatives were further examined in terms of their abilities to inhibit tubulin polymerization; however, all of the tested compounds were relatively ineffective. The reference compound E7010 with an IC(50) of 0.34 microM exhibited potent antiproliferative activity and significantly inhibited tubulin polymerization in a dose-dependent manner.
authors.affiliation: College of Pharmacy, Chungbuk National University, Cheongju 361-763, Republic of Korea. orgjkjung@chungbuk.ac.kr
authors.forename: Jin-Kyung
authors.initials: JK
authors.lastname: In
authors.forename: Mi-Sung
authors.initials: MS
authors.lastname: Lee
authors.forename: Jung-Eun
authors.initials: JE
authors.lastname: Yang
authors.forename: Jae-Hwan
authors.initials: JH
authors.lastname: Kwak
authors.forename: Heesoon
authors.initials: H
authors.lastname: Lee
authors.forename: Shanthaveerappa K
authors.initials: SK
authors.lastname: Boovanahalli
authors.forename: Kyeong
authors.initials: K
authors.lastname: Lee
authors.forename: Soo Jin
authors.initials: SJ
authors.lastname: Kim
authors.forename: Seung Kee
authors.initials: SK
authors.lastname: Moon
authors.forename: Sungsook
authors.initials: S
authors.lastname: Lee
authors.forename: Nam Song
authors.initials: NS
authors.lastname: Choi
authors.forename: Soon Kil
authors.initials: SK
authors.lastname: Ahn
authors.forename: Jae-Kyung
authors.initials: JK
authors.lastname: Jung
mesh_terms: D050256:Antimitotic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004987:Ethers / Q000138:chemical synthesis* / Q000494:pharmacology*; D018922:HL-60 Cells; D006801:Humans; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D008938:Mitosis / Q000187:drug effects; D013329:Structure-Activity Relationship; D014404:Tubulin / Q000096:biosynthesis
chemical_list: D050256:Antimitotic Agents; D004987:Ethers; D007202:Indicators and Reagents; D014404:Tubulin