title: [A case of fulminant hepatitis E treated with artificial liver support].
abstract: A 40-year-old man, who had suffered from general malaise and brown urine during his stay in China, was admitted with remarkable jaundice and hepatocellular disorders soon after he returned to Japan. Because his coagulation test results worsened, he was transferred to our hospital. No evidence of hepatitis A-D virus infection, autoimmune hepatitis, or metabolic disorders was noticed. His prothrombin time was extended (18%), grade II encephalopathy appeared on the second hospital day, and fulminant hepatitis was diagnosed. Artificial liver support was introduced, and his hepatic coma and coagulation parameters gradually recovered. Genotype IV hepatitis E virus RNA was detected in his early phase sera and also both IgG and IgM type anti-hepatitis E virus antibodies were detected. Fulminant hepatitis E resulting from infection in China was diagnosed.
authors.affiliation: Department of Internal Medicine, School of Medicine, Keio University.
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Fujiyama
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Yamagishi
authors.forename: Masahiro
authors.initials: M
authors.lastname: Kikuchi
authors.forename: Kenichiro
authors.initials: K
authors.lastname: Shimoji
authors.forename: Shinzo
authors.initials: S
authors.lastname: Kato
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nagata
authors.forename: Hidetsugu
authors.initials: H
authors.lastname: Saito
authors.forename: Toshifumi
authors.initials: T
authors.lastname: Hibi
authors.forename: Syunji
authors.initials: S
authors.lastname: Mishiro
mesh_terms: D000328:Adult; D002681:China; D005838:Genotype; D017583:Hemodiafiltration; D006501:Hepatic Encephalopathy / Q000175:diagnosis / Q000628:therapy*; D016751:Hepatitis E / Q000175:diagnosis / Q000628:therapy*; D016752:Hepatitis E virus / Q000235:genetics; D006801:Humans; D019164:Liver, Artificial; D008297:Male; D014195:Travel