title: Development of a cone-shape phantom for multi-voxel MR spectroscopy.
abstract: The purpose of this study was to develop a cone-shape phantom for multi-voxel magnetic resonance spectroscopy (MRS) and to evaluate MR spectra using the cone-shape phantom we developed in this study. A cone-shape MRS phantom was developed with a combination of cone-shape vials. The cylindrical main body was made of acrylic resin and the cone-shape vials were fabricated from poly-ethylene cones. Each cone of the phantom was filled with various metabolite materials. 1.5T GE and 3T Philips systems were used for the single voxel spectroscopy (SVS) as well as for the multi-voxel spectroscopy (MVS). Identification and quantification of the metabolite materials in the cone-shape phantom were done by the SAGE post-program. The MR images and spectra of the cone-shape phantom were obtained from the assigned slice position. The high order shimming control provided enhanced resolution in the SVS and MVS. The area and amplitude were proportional to the metabolite volume in the voxel. The present study demonstrated that the cone-shape phantom was useful for the metabolite quantification. Thus, we propose that the cone-shape phantom can be used for the evaluation of quality control of the MR spectra obtained from SVS and MVS.
authors.affiliation: Department of Biomedical Engineering, College of Medicine, The Catholic University of Korea, #505 Banpo-Dong, Seocho-Gu, Seoul 137-040, South Korea.
authors.forename: Dong-Cheol
authors.initials: DC
authors.lastname: Woo
authors.forename: Bum-Soo
authors.initials: BS
authors.lastname: Kim
authors.forename: So-Lyung
authors.initials: SL
authors.lastname: Jung
authors.forename: Hyo-Jin
authors.initials: HJ
authors.lastname: Park
authors.forename: Hyang-Shuk
authors.initials: HS
authors.lastname: Rhim
authors.forename: Geon-Ho
authors.initials: GH
authors.lastname: Jahng
authors.forename: Bo-Young
authors.initials: BY
authors.lastname: Choe
mesh_terms: D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000378:metabolism; D001921:Brain / Q000033:anatomy & histology / Q000502:physiology*; D002794:Choline / Q000378:metabolism; D003401:Creatine / Q000378:metabolism; D006801:Humans; D019344:Lactic Acid / Q000378:metabolism; D008279:Magnetic Resonance Imaging / Q000379:methods*; D019047:Phantoms, Imaging
chemical_list: D001224:Aspartic Acid; D019344:Lactic Acid; D003401:Creatine; D002794:Choline