Monosomy 7 and deletion 7q in children and adolescents with acute myeloid leukemia: an international retrospective study.
Monosomy 7 (-7) and deletion 7q \del(7q)] are rare in childhood acute myeloid leukemia (AML). We retrospectively collected data on 258 children with AML or refractory anemia with excess blasts in transformation (RAEB-T) and -7 or del(7q) with or without other cytogenetic aberrations \+/- other]. Karyotypes included -7 (n = 90), -7 other (n = 82), del(7q) (n = 21), and del(7q) other (n = 65). Complete remission (CR) was achieved in fewer patients with -7 +/- other compared with del(7q) +/- other (61% versus 89%, P < .001). Overall, the 5-year survival rate was 39% (SE, 3%). Survival was superior in del(7q) +/- other compared with -7 +/- other (51% versus 30%, P < .01). Cytogenetic aberrations considered favorable in AML \t(8;21)(q22;q22), inv(16)(p13q22), t(15;17)(q22;q21), t(9;11)(p22;q23)] (n = 24) were strongly associated with del(7q) and a higher 5-year survival rate compared with del(7q) without favorable cytogenetics (75% versus 46%, P = .03). Patients with -7 and inv(3),-5/del(5q), or + 21 had a 5-year survival rate of 5%. Stem cell transplantation analyzed as a time-dependent variable had no impact on overall survival. However, patients not achieving CR had a 31% survival rate after stem cell transplantation. Childhood AML with chromosome 7 aberrations represents a heterogeneous group of disorders with additional cytogenetic aberrations having a major prognostic impact which should be reflected in future risk-group stratification.
Hasle
Henrik
H
Department of Pediatrics, Aarhus University Hospital Skejby, Aarhus, Denmark. hasle@dadlnet.dk
Alonzo
Todd A
TA
Auvrignon
Anne
A
Behar
Catherine
C
Chang
Myron
M
Creutzig
Ursula
U
Fischer
Alexandra
A
Forestier
Erik
E
Fynn
Alcira
A
Haas
Oskar A
OA
Harbott
Jochen
J
Harrison
Christine J
CJ
Heerema
Nyla A
NA
van den Heuvel-Eibrink
Marry M
MM
Kaspers
Gertjan J L
GJ
Locatelli
Franco
F
Noellke
Peter
P
Polychronopoulou
Sophia
S
Ravindranath
Yaddanapudi
Y
Razzouk
Bassem
B
Reinhardt
Dirk
D
Savva
Natalia N
NN
Stark
Batia
B
Suciu
Stefan
S
Tsukimoto
Ichiro
I
Webb
David K
DK
Wojcik
Dorora
D
Woods
William G
WG
Zimmermann
Martin
M
Niemeyer
Charlotte M
CM
Raimondi
Susana C
SC
D000293:Adolescent; D002648:Child; D002869:Chromosome Aberrations; D002897:Chromosomes, Human, Pair 7; D005260:Female; D017353:Gene Deletion; D006801:Humans; D007391:International Cooperation; D015470:Leukemia, Myeloid, Acute / Q000235:genetics* / Q000401:mortality*; D008297:Male; D009006:Monosomy; D012074:Remission Induction; D012189:Retrospective Studies; D033581:Stem Cell Transplantation; D014178:Translocation, Genetic