title: Biomonitoring of environmental estrogens in human tissues.
abstract: Two examples are presented for the application of the total effective xenoestrogen burden as biomarker of chemical exposure measured in tissue samples from patients recruited for two case-control studies. The first study focused on environmental chemicals with hormone mimicking activity, the so-called environmental estrogens, and their participation in the etiology of breast cancer. The second study investigated mother-child exposure to persistent organochlorine chemicals and assessed their combined effect on the risk of male urogenital malformations in the newborn.
authors.affiliation: Laboratory Medical Investigations, University of Granada, Hospital Clinico, Granada, Spain.
authors.forename: Mariana F
authors.initials: MF
authors.lastname: Fernandez
authors.forename: Jose M
authors.initials: JM
authors.lastname: Molina-Molina
authors.forename: Maria-Jose
authors.initials: MJ
authors.lastname: Lopez-Espinosa
authors.forename: Carmen
authors.initials: C
authors.lastname: Freire
authors.forename: Cristina
authors.initials: C
authors.lastname: Campoy
authors.forename: Jesus
authors.initials: J
authors.lastname: Ibarluzea
authors.forename: Pablo
authors.initials: P
authors.lastname: Torne
authors.forename: Vicente
authors.initials: V
authors.lastname: Pedraza
authors.forename: Nicolas
authors.initials: N
authors.lastname: Olea
mesh_terms: D000273:Adipose Tissue / Q000737:chemistry*; D000328:Adult; D000368:Aged; D015415:Biomarkers; D001943:Breast Neoplasms / Q000453:epidemiology; D016022:Case-Control Studies; D004781:Environmental Exposure / Q000009:adverse effects; D004784:Environmental Monitoring / Q000379:methods*; D062665:Epidemiological Monitoring; D004967:Estrogens / Q000032:analysis*; D005260:Female; D006306:Health Surveys; D006801:Humans; D006843:Hydrocarbons, Chlorinated / Q000032:analysis; D007231:Infant, Newborn; D008297:Male; D018811:Maternal Exposure; D008875:Middle Aged; D010575:Pesticides / Q000032:analysis; D010920:Placenta / Q000737:chemistry; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D013030:Spain; D014564:Urogenital Abnormalities / Q000453:epidemiology*; D015262:Xenobiotics / Q000032:analysis*
chemical_list: D015415:Biomarkers; D004967:Estrogens; D006843:Hydrocarbons, Chlorinated; D010575:Pesticides; D015262:Xenobiotics