Interleukin-1 beta-511 polymorphism and risk of cervical cancer.
Cervical cancer is almost invariably associated with infection by human papillomavirus. It is believed that the host genetic factors such as inflammation-induced cytokines may play a role in cervical carcinogenesis. The IL1B gene, encoding IL-1beta cytokine, contains several single nucleotide polymorphisms. One of them which is in the positions -511 (C-T) related with promoter region has been associated with increased IL-1beta production and with increased risk of developing a number of inflammatory diseases and gastric carcinoma. We assessed the association between the IL1B -511 polymorphism and cervical cancer risk in a hospital-based case-control study among 546 Korean women (182 cases; 364 age-matched controls). The allele frequencies of the case subjects (C, 0.42; T, 0.58) were not significantly different from those of control subjects (C, 0.43; T, 0.57). Control subjects were in Hardy-Weinberg equilibrium. The carriers with -511 C/T or T/T genotypes were at higher risk of cervical cancer with odds ratio of 2.42 (95% CI 1.31-4.46, p<0.005). However, there was no difference of cervical cancer risk between C/T heterologous genotypes and T/T homologous genotypes. In conclusion, in Korean population, IL1B -511 C/C genotypes were significantly associated with a decreased risk of cervical cancer.
Kang
Sokbom
S
Uterine Cancer Branch, Research Institute and Hospital, National Cancer Center, Goyang, Korea.
Kim
Jae Weon
JW
Park
Noh Hyun
NH
Song
Yong Sang
YS
Park
Sang Yoon
SY
Kang
Soon Beom
SB
Lee
Hyo Pyo
HP
D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D053583:Interleukin-1beta / Q000235:genetics*; D011110:Polymorphism, Genetic; D002583:Uterine Cervical Neoplasms / Q000209:etiology / Q000235:genetics*
D053583:Interleukin-1beta