Neuropsychological abnormalities in patients with dementia in CRF 01_AE HIV-1 infection.
HIV-associated dementia (HAD) is not firmly established in patients with circulating recombinant form (CRF) 01_AE HIV-1. In this study, we compared neuropsychological performance among 15 Thai individuals with HAD, 15 Thai individuals without HAD, and 30 HIV-negative control subjects. HIV-1 participants were highly active anti-retroviral therapy naive and matched by age, education, and CD4 count. Neuropsychological testing abnormalities were identified in most cognitive domains among HAD vs HIV-negative participants, confirming the presence of HAD in CRF01_AE.
Valcour
V G
VG
Hawaii AIDS Clinical Research Program, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, USA. Vvalcour@hawaii.edu
Sithinamsuwan
P
P
Nidhinandana
S
S
Thitivichianlert
S
S
Ratto-Kim
S
S
Apateerapong
W
W
Shiramizu
B T
BT
Desouza
M S
MS
Chitpatima
S T
ST
Watt
G
G
Chuenchitra
T
T
Robertson
K R
KR
Paul
R H
RH
McArthur
J C
JC
Kim
J H
JH
Shikuma
C M
CM
D015526:AIDS Dementia Complex / Q000097:blood / Q000523:psychology / Q000821:virology*; D000328:Adult; D003071:Cognition; D015331:Cohort Studies; D005260:Female; D015497:HIV-1 / Q000145:classification* / Q000235:genetics*; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000821:virology*; D009422:Nervous System Diseases / Q000821:virology*; D009483:Neuropsychological Tests; D011995:Recombination, Genetic; D012720:Severity of Illness Index