title: Clinical findings in two cases of atypical scrapie in sheep: a case report.
abstract: BACKGROUND
  Atypical scrapie is a recently recognised form of transmissible spongiform encephalopathy of sheep that differs from classical scrapie in its neuropathological and biochemical features. Most cases are detected in apparently healthy sheep and information on the clinical presentation is limited.
  
  
  METHODS
  This report describes the clinical findings in two sheep notified as scrapie suspects and confirmed as atypical scrapie cases by immunohistochemistry and Western immunoblotting. Although both sheep displayed signs suggestive of a cerebellar dysfunction there was considerable variation in the individual clinical signs, which were similar to classical scrapie.
  
  
  CONCLUSIONS
  Any sheep presenting with neurological gait deficits should be assessed more closely for other behavioural, neurological and physical signs associated with scrapie and their presence should lead to the suspicion of scrapie.
authors.affiliation: Neuropathology, Veterinary Laboratories Agency Weybridge, New Haw, Addlestone, UK. t.konold@vla.defra.gsi.gov.uk
authors.forename: Timm
authors.initials: T
authors.lastname: Konold
authors.forename: Andrew
authors.initials: A
authors.lastname: Davis
authors.forename: Gemma
authors.initials: G
authors.lastname: Bone
authors.forename: John
authors.initials: J
authors.lastname: Bracegirdle
authors.forename: Sharon
authors.initials: S
authors.lastname: Everitt
authors.forename: Melanie
authors.initials: M
authors.lastname: Chaplin
authors.forename: Ginny C
authors.initials: GC
authors.lastname: Saunders
authors.forename: Saira
authors.initials: S
authors.lastname: Cawthraw
authors.forename: Marion M
authors.initials: MM
authors.lastname: Simmons
mesh_terms: D000818:Animals; D001921:Brain / Q000473:pathology / Q000503:physiopathology; D005260:Female; D018620:PrPSc Proteins / Q000032:analysis / Q000378:metabolism; D012608:Scrapie / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D012756:Sheep; D014279:Trigeminal Nucleus, Spinal / Q000378:metabolism / Q000473:pathology
chemical_list: D018620:PrPSc Proteins