The V617F mutation of JAK2 is very uncommon in patients with thrombosis.
Given that many cases of thrombosis do not have a clear cause, a myeloproliferative disease could be involved. We investigated the V617F mutation of the JAK2 gene in 295 patients with thrombosis. Only one case was positive. Therefore, the study of this mutation is not necessary in all patients with idiopathic thrombosis.
Remacha
Angel F
AF
Estivill
Camino
C
Sarda
M Pilar
MP
Mateo
José
J
Souto
Joan Carles
JC
Canals
Carme
C
Nomdedéu
Josep
J
Fontcuberta
Jordi
J
D000368:Aged; D015331:Cohort Studies; D005260:Female; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D053614:Janus Kinase 2 / Q000097:blood* / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009154:Mutation; D011087:Polycythemia Vera / Q000150:complications / Q000235:genetics; D013920:Thrombocythemia, Essential / Q000150:complications / Q000235:genetics; D013927:Thrombosis / Q000097:blood* / Q000235:genetics*
D006454:Hemoglobins; D053614:Janus Kinase 2