[Genetics in patients with psoriatic arthritis].
OBJECTIVE
HLA antigens were studied in 100 Hungarian patients suffered from psoriatic arthritis. Genetic markers for the development of different clinical pattern of the disease and skin disorder were identified.


METHODS
Determination of class I and class II antigens was performed by using microlymphocytotoxicity assay.


RESULTS
The frequency of HLA-Cw6, HLA-B16 (and its split B-39) and HLA-B27 antigens were significantly higher in psoriatic arthritis patients than in the Hungarian general population. No connection was found between HLA-DR4, DR7, B17 antigens and psoriatic arthritis. The patients were classified according to the subgroups proposed by Gladman. The comparisons between the clinical subgroups revealed a significant association of HLA-B27 with spondylitis (Gladman 4, 5, 6, 7). There was no association between HLA DR4 and polyarticular pattern of the disease (Gladman 3, 7). Psoriasis seemed to be significantly associated only with HLA-Cw6. There was a higher frequency of HLA-B38 in psoriatic arthritis patients with erythroderma.
Imre
Katalin
K
imre.katalin@irgalmas.hu
Koó
Eva
E
Seszták
Magdolna
M
Bosák
Vladimir
V
Bitterova
Olga
O
D000328:Adult; D000368:Aged; D015535:Arthritis, Psoriatic / Q000235:genetics* / Q000276:immunology*; D005260:Female; D015796:HLA-B27 Antigen / Q000032:analysis; D015236:HLA-C Antigens / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012307:Risk Factors; D013166:Spondylitis / Q000235:genetics / Q000276:immunology
D015796:HLA-B27 Antigen; D015236:HLA-C Antigens; C528994:HLA-C*06 antigen