title: Effect of ovary lipid of skipjack tuna on rat serum components after stress application.
abstract: Lipid extracted from the ovary of skipjack tuna by the method that we developed is rich in phospholipid-type docosahexaenoic acid. The ovary lipid of skipjack tuna (OLS) was studied for its anti-stress activity in male Wistar rats, focusing on stress-related blood components: recovery from stress was examined after application of water immersion restraint stress. As a result, serum corticosterone (CORT) secretion was inhibited and decreased rapidly after stress application in rats given OLS compared with control rats. As CORT acts as a glucocorticoid, non-esterified fatty acid (NEFA) is expected to increase by stress application. However, the concentration tended to be lower in rats given OLS than in control rats. With respect to OLS concentration, OLS increased serum dehydroepiandrosterone, secretion concentration-dependently. In addition, as with the recovery study, it tended to inhibit the increase in NEFA. These results indicate that OLS may have an anti-stress activity against acute stress.
authors.affiliation: Shizuoka Industrial Research Institute of Shizuoka Prefecture, Aoi, Japan.
authors.forename: Katumasa
authors.initials: K
authors.lastname: Ookawa
authors.forename: Kazuo
authors.initials: K
authors.lastname: Mochizuki
authors.forename: Yoshikuni
authors.initials: Y
authors.lastname: Sugimoto
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Suzuki
authors.forename: Masayuki
authors.initials: M
authors.lastname: Hashizume
authors.forename: Tomoko
authors.initials: T
authors.lastname: Kitagawa
authors.forename: Toru
authors.initials: T
authors.lastname: Matumoto
authors.forename: Chiaki
authors.initials: C
authors.lastname: Ito
authors.forename: Hidehiko
authors.initials: H
authors.lastname: Yokogoshi
mesh_terms: D000818:Animals; D001835:Body Weight; D003345:Corticosterone / Q000097:blood; D003687:Dehydroepiandrosterone / Q000097:blood; D004281:Docosahexaenoic Acids / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D004435:Eating / Q000187:drug effects; D005260:Female; D008297:Male; D010053:Ovary / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D018709:Statistics, Nonparametric; D013312:Stress, Physiological / Q000188:drug therapy*; D014413:Tuna
chemical_list: D004281:Docosahexaenoic Acids; D003687:Dehydroepiandrosterone; D003345:Corticosterone