Fabricating nanofluidic channels and Applying it for single bio-molecule study.
In the emerging field of nanobiotechnology, further downsizing the fluidic channels to the nanometer scale is attractive for both fundamental studies and technical applications. The insulation Silicon nitride membrane nanofluidic channel array which have width&#8764;75nm and depth &#8764; 100nm and length 50&#956;m were created by focused-ion- beam instrument, the&#955;--DNA molecules were put inside them and the dynamic characteristics were initial studied, a fluorescence microscopy was used to observe the images. We observed &#955;--DNA moved inside the nanotrenches which dealt with activating reagent Brij aqueous solution only by capillary force,this will help us to understand more DNA dynamics characteristics and more information about single biomolecule transporting through a nanopore,.
Kaige
Wang
W
Institute of Optoelectronics, Shenzhen University, Shenzhen 518060, China; Laboratory of Soft Matter Physics, Institute ofPhysics, CAS, Beijing 100080, China; Anhui Institute of Optics & Precision Mechanics,CAS, Hefei 230031 China.
Pengye
Wang
W
Hong
Wang
W
Changzhi
Gu
G
Shuanglin
Yue
Y
Aizi
Jin
J
Wenqing
Liu
L
Hanben
Niu
N