title: Long-term efficacy of low-density lipoprotein apheresis for focal and segmental glomerulosclerosis.
abstract: Recently, there have been reports on the efficacy of low-density lipoprotein (LDL) apheresis (LDL-A) for focal and segmental glomerulosclerosis (FSGS) in pediatric patients. However, there have been few reports on the long-term efficacy of LDL-A for FSGS in such patients. We report here a case of long-term efficacy of LDL-A for FSGS. The patient was a 13-year-old boy with FSGS who presented with steroid-resistant and cyclosporine-resistant nephrotic syndrome and hyperlipidemia. LDL-A was performed 24 times on one year. Following LDL-A, serum concentrations of LDL, very low-density lipoprotein (VLDL), apoprotein B, and vascular endothelial growth factor significantly decreased, and urinary excretion of protein also decreased. In addition, 3 years after LDL-A, the pathology findings on a second renal biopsy had improved. The patient has been in remission from FSGS for 12 years since LDL-A. These findings suggest that LDL-A may be useful in maintaining long-term remission from pediatric FSGS.
authors.affiliation: Department of Pediatrics, Fukushima Medical University School of Medicine, 1 Hikariga-oka, Fukushima City, Fukushima 960-1295, Japan. tomo@fmu.ac.jp
authors.forename: Yukihiko
authors.initials: Y
authors.lastname: Kawasaki
authors.forename: Sigeo
authors.initials: S
authors.lastname: Suzuki
authors.forename: Ayumi
authors.initials: A
authors.lastname: Matsumoto
authors.forename: Kei
authors.initials: K
authors.lastname: Takano
authors.forename: Kazuhide
authors.initials: K
authors.lastname: Suyama
authors.forename: Koichi
authors.initials: K
authors.lastname: Hashimoto
authors.forename: Junzo
authors.initials: J
authors.lastname: Suzuki
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Suzuki
authors.forename: Mitsuaki
authors.initials: M
authors.lastname: Hosoya
mesh_terms: D000293:Adolescent; D001781:Blood Component Removal; D004351:Drug Resistance; D005923:Glomerulosclerosis, Focal Segmental / Q000097:blood / Q000150:complications / Q000628:therapy*; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood / Q000150:complications / Q000628:therapy; D007678:Kidney Glomerulus / Q000473:pathology; D008077:Lipoproteins, LDL / Q000097:blood*; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D009404:Nephrotic Syndrome / Q000097:blood / Q000209:etiology / Q000628:therapy; D016896:Treatment Outcome
chemical_list: D008077:Lipoproteins, LDL; D008775:Methylprednisolone