Cytotoxic and antiprotozoal activity of flavonoids from Lonchocarpus spp.
A number of flavonoids isolated from Lonchocarpus spp. were evaluated for their antiprotozoal and cytotoxic activity. Flavone 6 and chalcone 7 were found to be the most active against Leishmania parasites and against cell cultures of Leukemia P388DI and adenocarcinoma prostate PC-3.
Borges-Argáez
R
R
Centro de Investigación Científica de Yucatán, Calle 43 No 130 Chuburná, Mérida, Yucatán, México.
Balnbury
L
L
Flowers
A
A
Giménez-Turba
A
A
Ruiz
G
G
Waterman
P G
PG
Peña-Rodríguez
L M
LM
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D000981:Antiprotozoal Agents / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D002453:Cell Cycle / Q000187:drug effects*; D045744:Cell Line, Tumor; D029866:Derris / Q000737:chemistry*; D047309:Flavones / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D006801:Humans; D007938:Leukemia / Q000473:pathology; D008297:Male; D015394:Molecular Structure; D008517:Phytotherapy; D011471:Prostatic Neoplasms / Q000473:pathology
D000972:Antineoplastic Agents, Phytogenic; D000981:Antiprotozoal Agents; D047309:Flavones