title: The influence of n-6 fatty acid supplemented diet on the effect of imipramine in an animal model of depression.
abstract: Recent data have shown an association between polyunsaturated fatty acid and depression. This study examined the effect of the supplementation with n-6 fatty acid on the behavior of rats treated with imipramine and submitted to the Forced Swimming Test (FST). Non-supplemented imipramine-treated rats presented a significant reduction of immobility time in the FST whereas n-6 fatty acid-supplemented rats showed a significantly higher immobility time. Imipramine significantly increased norepinephrine plasma concentrations in the two groups. These results show that the diet supplemented with n-6 fatty acid altered the behavior of the animals in the FST, inhibiting the imipramine effect.
authors.affiliation: Department of Psychobiology, Federal University of São Paulo, São Paulo, Brazil. ellizabethe@psicobio.epm.br
authors.forename: Elizabethe C
authors.initials: EC
authors.lastname: Borsonelo
authors.forename: Jose C F
authors.initials: JC
authors.lastname: Galduróz
authors.forename: Deborah
authors.initials: D
authors.lastname: Suchecki
authors.forename: Helena M
authors.initials: HM
authors.lastname: Calil
mesh_terms: D000818:Animals; D000929:Antidepressive Agents, Tricyclic / Q000494:pharmacology*; D001835:Body Weight / Q000187:drug effects; D002395:Catecholamines / Q000097:blood; D002851:Chromatography, High Pressure Liquid; D003863:Depression / Q000188:drug therapy* / Q000523:psychology; D004032:Diet; D004563:Electrochemistry; D043371:Fatty Acids, Omega-6 / Q000494:pharmacology*; D007099:Imipramine / Q000494:pharmacology*; D008297:Male; D010938:Plant Oils / Q000737:chemistry; D031825:Primula / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin / Q000097:blood; D013550:Swimming / Q000523:psychology
chemical_list: D000929:Antidepressive Agents, Tricyclic; D002395:Catecholamines; D043371:Fatty Acids, Omega-6; D010938:Plant Oils; D012701:Serotonin; D007099:Imipramine