Age-dependent changes in iron deposition in the gerbil hippocampus.
In this study, we focused on age-dependent changes in intracellular iron deposition in the gerbil hippocampus. At 1 month of age (PM 1), iron reactivity was weak in the gerbil hippocampus. At this time, cells in the polymorphic layer of the dentate gyrus showed weak iron reactivity. At PM 3, iron reactivity in cells had not changed significantly. Thereafter, iron reactivity in the CA1-3 regions and in the dentate gyrus increased with time until PM 18. At PM 24, iron reactivity in all the subfields was similar to that at PM 18. In animals aged PM 18-24, iron positive cells had various shapes, and had processes which contained iron. These results suggest that the increase of iron deposition may be associated with normal aging and that the iron deposition in the aged hippocampus is different according to hippocampal subfields.
Yoo
Ki-Yeon
KY
Department of Anatomy, College of Medicine, Hallym University, Chuncheon 200-702, South Korea.
Hwang
In Koo
IK
Kang
Il-Jun
IJ
Kang
Tae-Cheon
TC
Lee
Hak-Ju
HJ
Kang
Ha-Young
HY
Lee
Hyeon Yong
HY
Oh
Yang-Seok
YS
Won
Moo Ho
MH
D000375:Aging / Q000378:metabolism*; D000818:Animals; D018891:Dentate Gyrus / Q000378:metabolism; D005849:Gerbillinae; D006624:Hippocampus / Q000166:cytology / Q000378:metabolism*; D007501:Iron / Q000378:metabolism*; D008297:Male; D009836:Oligodendroglia / Q000378:metabolism
D007501:Iron