Pathogenesis of acute myocardial infarction in young male adults with or without obesity.
OBJECTIVE
Obesity may be linked with coronary atherosclerosis in young males. This study investigated the etiology of acute myocardial infarction (AMI) in young Japanese male patients with or without obesity.


RESULTS
This retrospective study included 2,230 AMI patients enrolled in the AMI-Kyoto Multi-Center Risk Study between January 2000 and December 2005. Clinical background, risk factors, angiographic findings, acute results of primary percutaneous coronary intervention (PCI), and in-hospital outcome were evaluated in 33 young male patients < 40 years old. The study group was divided into the obese group [body mass index (BMI) > or =25, n=21] and non-obese group (BMI < 25, n=12). Four of the 12 non-obese patients had underlying disease (Kawasaki disease 2, Buerger's disease 1, drug abuse 1). The non-obese group had a higher prevalence of underlying disease than the obese group. The non-obese group had a higher incidence of left anterior descending coronary artery as culprit lesion and higher Thrombolysis in Myocardial Infarction (TIMI) grade flow in the infarct-related artery before primary PCI. The acquisition rates of TIMI 3 flow after primary PCI and in-hospital outcome did not differ between the two groups.


CONCLUSIONS
Non-obese young AMI male patients have a higher frequency of underlying disease. Most young male AMI patients were obese, suggesting that obesity may be important in the pathogenesis of AMI in young male adults.
Shiraishi
Jun
J
Department of Cardiology, Kyoto First Red Cross Hospital, Kyoto. sjun@msj.biglobe.ne.jp
Kohno
Yoshio
Y
Sawada
Takahisa
T
Nishizawa
Shinya
S
Arihara
Masayasu
M
Hadase
Mitsuyoshi
M
Hyogo
Masayuki
M
Yagi
Takakazu
T
Shima
Takatomo
T
Matoba
Satoaki
S
Yamada
Hiroyuki
H
Tatsumi
Tetsuya
T
Azuma
Akihiro
A
Matsubara
Hiroaki
H
D000328:Adult; D000800:Angioplasty, Balloon; D015992:Body Mass Index; D003324:Coronary Artery Disease / Q000209:etiology; D006801:Humans; D008297:Male; D009080:Mucocutaneous Lymph Node Syndrome / Q000150:complications / Q000453:epidemiology; D009203:Myocardial Infarction / Q000453:epidemiology* / Q000209:etiology* / Q000628:therapy; D009765:Obesity / Q000150:complications* / Q000453:epidemiology*; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors