[Study on polymorphisms in metabolic enzyme genes, DNA repair genes and individual susceptibility to hepatocellular carcinoma].
Hepatocellualr carcinoma is one of the most malignancy, and the pathogenesis has not been clarified yet. The individual variation in the capacity of xenobiotic metabolizing and DNA repair was the genetic susceptibility to malignancies. Studies on polymorphisms of metabolic enzymes (CYP, NAT, GST, EH, ALDH) and DNA repair genes (XRCC1,hOGG1,XPD), and susceptibility to hepatocellular carcinoma are reviewed in this paper.
Ye
Xin-ping
XP
Department of Hepatobiliary Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China.
Peng
Tao
T
Li
Le-qun
LQ
D006528:Carcinoma, Hepatocellular / Q000235:genetics*; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics*; D004260:DNA Repair / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D005982:Glutathione Transferase / Q000235:genetics; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics*; D009195:Peroxidase / Q000235:genetics; D011110:Polymorphism, Genetic
D003577:Cytochrome P-450 Enzyme System; D009195:Peroxidase; D005982:Glutathione Transferase