title: Lack of effect of short-term diazoxide administration on luteinizing hormone secretion in women with polycystic ovary syndrome.
abstract: OBJECTIVE
  To test the hypothesis that an acute reduction in circulating insulin affects LH secretion in women with polycystic ovary syndrome (PCOS).
  
  
  METHODS
  Prospective study in normal and PCOS women.
  
  
  METHODS
  General Clinical Research Centers at the University of Virginia, the Medical College of Virginia, and the Massachusetts General Hospital.
  
  
  METHODS
  Six normal women and five women with PCOS.
  
  
  METHODS
  Administration of diazoxide to lower circulating insulin concentrations.
  
  
  METHODS
  Characteristics of LH secretion as appraised by multiparameter deconvolution and estimation of approximate entropy.
  
  
  RESULTS
  Short-term administration of diazoxide had no effect on the secretion of LH in women with PCOS.
  
  
  CONCLUSIONS
  Hyperinsulinemia resulting from insulin resistance in women with PCOS may not have a direct effect on gonadotropin secretion.
authors.affiliation: Department of Medicine, National Science Foundation Center for Biological Timing, University of Virginia, Charlottesville, 22908, USA. wse2p@virginia.edu
authors.forename: William S
authors.initials: WS
authors.lastname: Evans
authors.forename: Ann E
authors.initials: AE
authors.lastname: Taylor
authors.forename: David G
authors.initials: DG
authors.lastname: Boyd
authors.forename: Michael L
authors.initials: ML
authors.lastname: Johnson
authors.forename: Dennis W
authors.initials: DW
authors.lastname: Matt
authors.forename: Yarisie
authors.initials: Y
authors.lastname: Jimenez
authors.forename: John E
authors.initials: JE
authors.lastname: Nestler
mesh_terms: D000328:Adult; D015331:Cohort Studies; D003981:Diazoxide / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood / Q000378:metabolism; D000078790:Insulin Secretion; D007986:Luteinizing Hormone / Q000097:blood / Q000378:metabolism*; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000188:drug therapy* / Q000378:metabolism*; D011446:Prospective Studies; D013997:Time Factors
chemical_list: D007328:Insulin; D007986:Luteinizing Hormone; D003981:Diazoxide