title: Chemical genetics: where genetics and pharmacology meet.
abstract: Genetics and pharmacology can elicit surprisingly different phenotypes despite targeting the same protein. This Essay explores these unexpected differences and their implications for biology and medicine.
authors.affiliation: Howard Hughes Medical Institute, Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94143, USA.
authors.forename: Zachary A
authors.initials: ZA
authors.lastname: Knight
authors.forename: Kevan M
authors.initials: KM
authors.lastname: Shokat
mesh_terms: D000494:Allosteric Regulation; D000818:Animals; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D005821:Genetic Techniques; D009154:Mutation; D010641:Phenotype; D010770:Phosphotransferases / Q000037:antagonists & inhibitors / Q000187:drug effects* / Q000235:genetics* / Q000378:metabolism; D011506:Proteins / Q000187:drug effects / Q000235:genetics / Q000378:metabolism
chemical_list: D004791:Enzyme Inhibitors; D011506:Proteins; D010770:Phosphotransferases