title: The novel use of small intestinal submucosal matrix for chest wall reconstruction following Ewing's tumour resection.
abstract: Chest wall reconstruction following major tumour resection remains a challenging problem in the paediatric population due to the need for growth and development following the repair. Synthetic non-biodegradable grafts and materials have led to asymmetrical growth and significant functional and cosmetic compromise. The ideal graft material should be biological non-immunogenic which enables natural healing and facilitates further growth. Ewing's sarcoma is an uncommon primitive neuroectodermal tumour which rarely occurs in the ribs. However, recent improvements in management have produced a significantly improved survival; increasing the importance of chest wall reconstruction. We prospectively assessed the utilisation of Surgisis (an acellular collagen matrix) as a replacement graft in two children undergoing primary chest wall reconstruction following tumour resection. Surgisis is derived from porcine small intestinal submucosa (SIS) that serves as a template for tissue reconstruction and remodeling. The graft was well tolerated; there was no herniation and it allowed normal symmetrical chest movement and growth to occur. The properties of SIS allows natural collagen growth and compares favourably with marlex mesh and other forms of chest wall reconstruction. We believe its unique properties allow it to act as a suitable framework for chest wall reconstruction allowing chest wall growth and development.
authors.affiliation: Department of Paediatric Surgery, Our Lady's Hospital for Sick Children, Crumlin, Dublin 12, Ireland. feilimmurphy@ireland.com
authors.forename: Feilim
authors.initials: F
authors.lastname: Murphy
authors.forename: Martin T
authors.initials: MT
authors.lastname: Corbally
mesh_terms: D001859:Bone Neoplasms / Q000473:pathology / Q000601:surgery*; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007413:Intestinal Mucosa / Q000637:transplantation; D007421:Intestine, Small / Q000166:cytology*; D008297:Male; D019651:Plastic Surgery Procedures / Q000379:methods*; D012272:Ribs; D012512:Sarcoma, Ewing / Q000473:pathology / Q000601:surgery*; D013899:Thoracic Neoplasms / Q000473:pathology / Q000601:surgery*; D019616:Thoracic Surgical Procedures / Q000379:methods; D035441:Thoracic Wall / Q000601:surgery*