title: Tumor Detection in vivo with Optical Spectroscopy.
abstract: Ultrasound induced blood stasis has been observed for a long time, but to date most experimental observations have been in vitro. In this paper we discuss a possible diagnostic use for this previously undesirable effect of ultrasound - tumor detection in vivo. We demonstrate that, using optical spectroscopy, effects of ultrasound can be used to differentiate tumor from non-tumor in murine tissue. Finally, we propose a novel diagnostic algorithm that quantitatively differentiates tumor from non-tumor with maximum specificity 0.83, maximum sensitivity 0.79, and area under ROC curve 0.90.
authors.affiliation: Radiation Oncology, School of Engineering and Applied Science, University of Rochester, Rochester, NY 14627.
authors.forename: V
authors.initials: V
authors.lastname: Misic
authors.forename: B
authors.initials: B
authors.lastname: Winey
authors.forename: H
authors.initials: H
authors.lastname: Liu
authors.forename: L
authors.initials: L
authors.lastname: Liao
authors.forename: P
authors.initials: P
authors.lastname: Okunieff
authors.forename: K
authors.initials: K
authors.lastname: Parker
authors.forename: B
authors.initials: B
authors.lastname: Fenton
authors.forename: Y
authors.initials: Y
authors.lastname: Yu