title: Visualization and characterization of drug carrier transportation and distribution in vivo.
abstract: Micro/nano-particle drug delivery systems are being developed for improving therapeutic effects. However, most studies can only evaluate the delivery properties by indirectly measuring the pharmacokinetic changes of the drugs. It had been difficult to directly assay the drug carrier status and distribution in vivo. We described here a method using intravital microscopy to visualize individual drug carriers traveling through blood vessels. The transportation and extravasation process of these particles were monitored. The in vivo distribution patterns were also confirmed by fluorescence microscopy studies of the various tissue samples.
authors.affiliation: School of Pharmacy, Shanghai Jiao Tong University, P. R. China.
authors.forename: Fang
authors.initials: F
authors.lastname: Geng
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Shen
authors.forename: Baowei
authors.initials: B
authors.lastname: Peng
authors.forename: Xiaohui
authors.initials: X
authors.lastname: Wei
authors.forename: Lisa
authors.initials: L
authors.lastname: Xu
authors.forename: Yuhong
authors.initials: Y
authors.lastname: Xu