title: Body mass index does not predict prostate-specific antigen or percent free prostate-specific antigen in men undergoing prostate cancer screening.
abstract: OBJECTIVE
  Body mass index (BMI) may alter serum prostate specific antigen (PSA) and percent free PSA (%fPSA) and may mask the risk of prostate cancer. We investigated the relationship between BMI and PSA or %fPSA.
  
  
  METHODS
  Height, weight, PSA and %fPSA were assessed in 616 consecutive screened men without prostate cancer. Continuously coded and categorised BMI was studied. Statistical analyses consisted of ANOVA, linear regression, bivariate and partial correlations.
  
  
  RESULTS
  Median age was 57 years. Median PSA was 1.0 and median %fPSA was 26. Median BMI was 25.8 kg/m(2). Neither continuously coded nor categorised BMI correlated with either PSA or %fPSA in unadjusted or age-adjusted analyses (all p values > or = 0.3).
  
  
  CONCLUSIONS
  Body mass index does not affect PSA or %fPSA in men without known prostate cancer, who undergo prostate cancer screening. Therefore, PSA or %fPSA-based screening or early detection efforts do not require an adjustment for BMI.
authors.affiliation: Cancer Prognostics and Health Outcomes Unit, University of Montreal Health Center, 1058, rue St-Denis, Montréal, Que, Canada.
authors.forename: Georg
authors.initials: G
authors.lastname: Hutterer
authors.forename: Paul
authors.initials: P
authors.lastname: Perrotte
authors.forename: Andrea
authors.initials: A
authors.lastname: Gallina
authors.forename: Jochen
authors.initials: J
authors.lastname: Walz
authors.forename: Claudio
authors.initials: C
authors.lastname: Jeldres
authors.forename: Miriam
authors.initials: M
authors.lastname: Traumann
authors.forename: Nazareno
authors.initials: N
authors.lastname: Suardi
authors.forename: Fred
authors.initials: F
authors.lastname: Saad
authors.forename: François
authors.initials: F
authors.lastname: Bénard
authors.forename: Luc
authors.initials: L
authors.lastname: Valiquette
authors.forename: Michael
authors.initials: M
authors.lastname: McCormack
authors.forename: Markus
authors.initials: M
authors.lastname: Graefen
authors.forename: Francesco
authors.initials: F
authors.lastname: Montorsi
authors.forename: Pierre I
authors.initials: PI
authors.lastname: Karakiewicz
mesh_terms: D000328:Adult; D017677:Age Distribution; D000368:Aged; D000704:Analysis of Variance; D015992:Body Mass Index; D015331:Cohort Studies; D006801:Humans; D008297:Male; D008403:Mass Screening / Q000379:methods; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000150:complications; D050177:Overweight / Q000502:physiology; D017430:Prostate-Specific Antigen / Q000097:blood*; D011471:Prostatic Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000503:physiopathology; D012307:Risk Factors
chemical_list: D017430:Prostate-Specific Antigen