Effects of cervical-lymphatic blockade on brain edema and infarction volume in cerebral ischemic rats.
To observe the effects of cervical-lymphatic blockade (CLB) on brain edema and infarction volume of ischemic (MCAO) rat, we examined changes in cerebral water content, Ca2+ and glutamate concentrations, cerebral infarction volume and mRNA expression levels of N-methyl-D-aspartame receptor 1 (NMDA receptor 1) in the ischemic (left) hemisphere. The present results demonstrated that all the above indices in rats with middle cerebral artery occlusion plus cervical lymphatic blockade (MCAO+CLB) were markedly higher than those with only middle cerebral artery occlusion (MCAO) at different time points. These results indicated [corrected] that CLB can aggravate cerebral ischemia by increasing brain edema and infarction volume.
Si
Jinchao
J
Institute of Physiology, School of Medicine, Shandong University, Jinan 250012, Shandong, P.R.China.
Chen
Lianbi
L
Xia
Zuoli
Z
D000818:Animals; D015152:Blotting, Northern; D001921:Brain / Q000378:metabolism; D001929:Brain Edema / Q000378:metabolism / Q000503:physiopathology*; D002118:Calcium / Q000378:metabolism; D018698:Glutamic Acid / Q000378:metabolism; D020244:Infarction, Middle Cerebral Artery / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology*; D042601:Lymphatic Vessels / Q000502:physiology*; D008297:Male; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism; D014867:Water / Q000378:metabolism
D012333:RNA, Messenger; D016194:Receptors, N-Methyl-D-Aspartate; D014867:Water; D018698:Glutamic Acid; D002118:Calcium