title: [Exposure of Tenon's capsule fibroblasts of pterygium to cyclosporin 0.05%].
abstract: OBJECTIVE
  To evaluate normal Tenon capsule fibroblasts and from pterygia in culture when exposed to cyclosporin 0.05%.
  
  
  METHODS
  A prospective, randomized study was done, involving 20 patients with primary pterygium. Samples of normal and pterygium Tenon's capsule from the same individual were collected, cultured and exposed to cyclosporin 0.05%.
  
  
  RESULTS
  Only 7 samples could be exposed to cyclosporin--6 from pterygial Tenon's capsule and 1 from normal Tenon's capsule. There was a significant reduction of cellular proliferation in the cyclosporin exposed cultures (p<0.05).
  
  
  CONCLUSIONS
  Cyclosporin 0.05% is effective to inhibit the proliferation of pterygia and normal Tenon's capsule fibroblasts. Further studies should be performed to define the role of cyclosporin in pterygium treatment.
authors.affiliation: Departamento de Oftalmologia, Otorrinolaringologia e Cirurgia de Cabeça e Pescoço, Faculdade de Medicina de Botucatu, Universidade Estadual Paulista Júlio Mesquita Filho, Botucatu, SP, Brazil.
authors.forename: Laura Almeida
authors.initials: LA
authors.lastname: Hercules
authors.forename: Magda Massae Hata
authors.initials: MM
authors.lastname: Viveiros
authors.forename: Silvana Artioli
authors.initials: SA
authors.lastname: Schellini
authors.forename: João
authors.initials: J
authors.lastname: Candeias
authors.forename: Carlos Roberto
authors.initials: CR
authors.lastname: Padovani
mesh_terms: D000704:Analysis of Variance; D002452:Cell Count / Q000379:methods; D002478:Cells, Cultured; D016572:Cyclosporine / Q000494:pharmacology*; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects*; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D011446:Prospective Studies; D011625:Pterygium / Q000473:pathology* / Q000601:surgery; D018709:Statistics, Nonparametric; D013997:Time Factors
chemical_list: D007166:Immunosuppressive Agents; D016572:Cyclosporine