Phosphine-free palladium-catalyzed C-H bond arylation of free (N-H)-indoles and pyrroles.
This paper describes a phosphine-free palladium-catalyzed method for direct C-arylation of free (N-H)-indoles and pyrroles with iodo- and bromoarene donors. Employing commercially available materials, this new and operationally simple procedure provides a rapid entry to a wide range of C-arylated (N-H)-indoles including derivatives of tryptamine. In the course of this study, a profound halide effect was uncovered, affecting both the efficiency and regioselectivity of indole arylation.
Wang
Xiang
X
Department of Chemistry, Columbia University, 3000 Broadway, New York, NY 10027, USA.
Gribkov
Denis V
DV
Sames
Dalibor
D
D002384:Catalysis; D007211:Indoles / Q000737:chemistry*; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D010720:Phosphines; D011758:Pyrroles / Q000737:chemistry*
D007211:Indoles; D010720:Phosphines; D011758:Pyrroles; D010165:Palladium