title: Impact of surgically induced weight loss on cardiovascular autonomic function: one-year follow-up.
abstract: OBJECTIVE
  To determine the impact of surgically induced weight loss on cardiovascular autonomic function in subjects with severe obesity and examine whether the effect was comparable for persons with and without diabetes.
  
  
  METHODS
  Twenty-six severely obese individuals (BMI = 48 +/- 7 kg/m(2)) underwent bariatric surgery (laparoscopic Roux-en-Y gastric bypass, n = 21; laparoscopic adjustable gastric banding, n = 5). Cardiovascular autonomic function (heart rate variation during deep breathing and the Valsalva maneuver) was assessed before and 6 and 12 months after surgery.
  
  
  RESULTS
  Twelve months after bariatric surgery, there was a 28% decrease in BMI. There was an increase in all parasympathetic indices of autonomic function (all assessment modalities, p < 0.05) with weight loss. The amount of improvement from baseline for all measures of autonomic function did not differ for those with or without diabetes.
  
  
  CONCLUSIONS
  Surgically induced weight loss 12 months after surgery has a favorable effect on cardiovascular autonomic function in severely obese individuals with and without diabetes.
authors.affiliation: Department of Medical Technology, University of Delaware, Newark, DE 19716, USA. rmaser@udel.edu
authors.forename: Raelene E
authors.initials: RE
authors.lastname: Maser
authors.forename: M James
authors.initials: MJ
authors.lastname: Lenhard
authors.forename: Isaias
authors.initials: I
authors.lastname: Irgau
authors.forename: Gail M
authors.initials: GM
authors.lastname: Wynn
mesh_terms: D000328:Adult; D017776:Autonomic Pathways / Q000502:physiology*; D050110:Bariatric Surgery; D002320:Cardiovascular Physiological Phenomena; D048909:Diabetes Complications / Q000503:physiopathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009767:Obesity, Morbid / Q000150:complications / Q000503:physiopathology* / Q000628:therapy*; D015431:Weight Loss