title: Synthesis of peptide-based polymers by microwave-assisted cycloaddition backbone polymerization.
abstract: The optimized reaction conditions for the Cu(I)-catalyzed N-->C polymerization of azido-phenylalanyl-alanyl-propargyl amide to yield either high molecular weight linear polymers or medium-sized cyclic polymers is described. These reaction conditions will be applied to tailor the synthesis, properties, and structure of biologically relevant peptide-based biopolymers.
authors.affiliation: Department of Medicinal Chemistry and Chemical Biology, and Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, P.O. Box 80082, 3508 TB Utrecht, The Netherlands.
authors.forename: Maarten van
authors.initials: Mv
authors.lastname: Dijk
authors.forename: Khalid
authors.initials: K
authors.lastname: Mustafa
authors.forename: Annemarie C
authors.initials: AC
authors.lastname: Dechesne
authors.forename: Cornelus F van
authors.initials: CF
authors.lastname: Nostrum
authors.forename: Wim E
authors.initials: WE
authors.lastname: Hennink
authors.forename: Dirk T S
authors.initials: DT
authors.lastname: Rijkers
authors.forename: Rob M J
authors.initials: RM
authors.lastname: Liskamp
mesh_terms: D000577:Amides / Q000737:chemistry; D001704:Biopolymers; D002384:Catalysis; D003300:Copper; D008872:Microwaves; D010455:Peptides / Q000138:chemical synthesis*; D011108:Polymers / Q000138:chemical synthesis*
chemical_list: D000577:Amides; D001704:Biopolymers; D010455:Peptides; D011108:Polymers; D003300:Copper