title: Antiadhesive effect of the mixed solution of sodium hyaluronate and sodium carboxymethylcellulose after endoscopic sinus surgery.
abstract: BACKGROUND
  We evaluated the clinical efficacy and safety of the mixed solution of sodium hyaluronate and sodium carboxymethylcellulose (HA-CMC) for prevention of adhesion after endoscopic sinus surgery.
  
  
  METHODS
  Preoperative computed tomography (CT) scans were graded. At the completion of surgery, HA-CMC was applied to Merocel and repeatedly applied after the removal of Merocel. As a control, normal saline was applied. Endoscopic examination was performed postoperatively and grading was done.
  
  
  RESULTS
  The rate of adhesion was the highest at 2 weeks postoperatively and was significantly lower in the HA-CMC-treated group than the control on all postoperative days. The grouping of cases by CT scores at 2 weeks postoperatively showed lower adhesion formation with the HA-CMC treatment than the control. The safety profile of the patients was normal at 4 weeks postoperatively.
  
  
  CONCLUSIONS
  HA-CMC is an efficacious and safe material in decreasing the incidence of adhesion after endoscopic sinus surgery.
authors.affiliation: Department of Otorhinolaryngology, Brain Korea 21 Project for Medical Science, Seoul, South Korea.
authors.forename: Jeong Hong
authors.initials: JH
authors.lastname: Kim
authors.forename: Joo-Hwan
authors.initials: JH
authors.lastname: Lee
authors.forename: Joo-heon
authors.initials: JH
authors.lastname: Yoon
authors.forename: Jung Hyun
authors.initials: JH
authors.lastname: Chang
authors.forename: Jung Ho
authors.initials: JH
authors.lastname: Bae
authors.forename: Kyung-Su
authors.initials: KS
authors.lastname: Kim
mesh_terms: D000268:Adhesiveness / Q000187:drug effects; D000276:Adjuvants, Immunologic / Q000008:administration & dosage / Q000627:therapeutic use*; D000293:Adolescent; D000328:Adult; D002266:Carboxymethylcellulose Sodium / Q000008:administration & dosage / Q000627:therapeutic use*; D004338:Drug Combinations; D004724:Endoscopy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006820:Hyaluronic Acid / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D011182:Postoperative Care / Q000379:methods*; D011183:Postoperative Complications / Q000517:prevention & control*; D012189:Retrospective Studies; D012852:Sinusitis / Q000000981:diagnostic imaging / Q000601:surgery*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D000276:Adjuvants, Immunologic; D004338:Drug Combinations; D006820:Hyaluronic Acid; D002266:Carboxymethylcellulose Sodium