title: [Study on the lowest acceptable intake of cow's milk for healthy adults].
abstract: OBJECTIVE
  [corrected] To find out the lowest acceptable intake of Cow's Milk in subjects with lactose intolerance(LI) and then observe intolerance symptoms in 280 healthy adults after they drank the milk.
  
  
  METHODS
  Eight LI subjects with watery diarrhea who were selected from 38 subjects by hydrogen breath test(HBT) were divided into group A, group B to go on drinking cow's milk test. The subjects in group A ingested 25g milk powder, the subjects in group B ingested 38.2g milk powder( contain 6.25g, 9.55g lactose respectively) according to literature and single factor optimization method (0.618 golden mean) to analyze their hydrogen excretion(ppm), symptom score and stool lactose. The 100 younger, the 80 middle-age and the 100 elder subjects were selected to observe symptoms after they ingested 25g milk powder.
  
  
  RESULTS
  hydrogen excretion(ppm) and symptom score in the high dose group (group B)are a little higher than those in low dose group(group A). No case with diarrhea occurred in these two group but mild symptoms. Most of healthy adults (80.3%) have no intolerance symptoms after they drank the milk.
  
  
  CONCLUSIONS
  The study demonstrates that most of adults, even with LI, can tolerance 25g cow's milk powder (6.25g lactose). It is suggested 20g cow's milk powder (5g lactose, make 160 ml of milk solution) is the lowest acceptable intake of healthy adults in China.
authors.affiliation: Department of Nutrition and Food Hygiene, West China School of Public Health, Sichuan University, Chengdu 610041, China.
authors.forename: Rong
authors.initials: R
authors.lastname: Qiao
authors.forename: Cheng-yu
authors.initials: CY
authors.lastname: Hung
authors.forename: Guo
authors.initials: G
authors.lastname: Zeng
authors.forename: Roel J
authors.initials: RJ
authors.lastname: Vonk
authors.forename: Ling
authors.initials: L
authors.lastname: Li
authors.forename: Sheng
authors.initials: S
authors.lastname: Ye
mesh_terms: D000328:Adult; D000368:Aged; D000818:Animals; D001944:Breath Tests; D002417:Cattle; D005243:Feces / Q000737:chemistry; D005260:Female; D006801:Humans; D007785:Lactose / Q000032:analysis; D007787:Lactose Intolerance / Q000178:diet therapy*; D007789:Lactose Tolerance Test; D008297:Male; D008875:Middle Aged; D008892:Milk
chemical_list: D007785:Lactose