Arenes to anilines and aryl ethers by sequential iridium-catalyzed borylation and copper-catalyzed coupling.
[reaction: see text] N-Alkyl- and N-arylanilines were synthesized from arenes by a two-step sequence of iridium-catalyzed borylation and copper-catalyzed coupling with amines. Diaryl ethers were obtained by a related sequence of arene borylation, followed by coupling with phenols. In particular, 3,5-disubstituted arylamines and aryl ethers were prepared by initiating this sequence with meta-substituted arenes.
Tzschucke
C Christoph
CC
Department of Chemistry, Yale University, P.O. Box 208107, New Haven, Connecticut 06520, USA.
Murphy
Jaclyn M
JM
Hartwig
John F
JF