De novo complex chromosomal rearrangement of 46, XY, t (3; 16; 8) (p26; q13; q21.2) in a non-obstructive azoospermic male.
Complex Chromosomal Rearrangements (CCRs) are rare structural abnormalities that are usually associated with infertility or subfertility in male carriers. We described clinical and chromosomal features of a non-obstructive azoospermic male that has been referred for infertility. Cytogenetic analysis showed three chromosomes, i.e. 3, 8 and 16, which have been involved and caused spermatogenesis failure.
Salahshourifar
Iman
I
Department of Infertility Genetics, Infertility Clinic & Reproductive Biomedicine Research Center, Royan Institute, Tehran, Iran. salahshouri@gmail.com
Gilani
Mohammad Ali Sedighi
MA
Vosough
Ahmad
A
Tavakolzadeh
Tayebeh
T
Tahsili
Masoumeh
M
Mansori
Zahra
Z
Karimi
Hamideh
H
Totonchi
Mehdi
M
Gourabi
Hamid
H
D000328:Adult; D053713:Azoospermia / Q000235:genetics*; D002885:Chromosomes, Human, Pair 16 / Q000235:genetics*; D002893:Chromosomes, Human, Pair 3 / Q000235:genetics*; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics*; D006801:Humans; D007621:Karyotyping; D008297:Male; D013091:Spermatogenesis / Q000235:genetics; D014178:Translocation, Genetic