title: Towards a theory of tiered testing.
abstract: Tiered testing is an essential part of any resource-efficient strategy for the toxicity testing of a large number of chemicals, which is required for instance in the risk management of general (industrial) chemicals, In spite of this, no general theory seems to be available for the combination of single tests into efficient tiered testing systems. A first outline of such a theory is developed. It is argued that chemical, toxicological, and decision-theoretical knowledge should be combined in the construction of such a theory. A decision-theoretical approach for the optimization of test systems is introduced. It is based on expected utility maximization with simplified assumptions covering factual and value-related information that is usually missing in the development of test systems.
authors.affiliation: Department of Philosophy and the History of Technology, Royal Institute of Technology, Stockholm, Sweden. soh@kth.se <soh@kth.se>
authors.forename: Sven Ove
authors.initials: SO
authors.lastname: Hansson
authors.forename: Christina
authors.initials: C
authors.lastname: Rudén
mesh_terms: D003661:Decision Support Techniques; D004781:Environmental Exposure / Q000331:legislation & jurisprudence; D006801:Humans; D012308:Risk Management / Q000331:legislation & jurisprudence / Q000379:methods; D018675:Toxicity Tests / Q000191:economics / Q000592:standards*