title: Metabolic alkalosis, bedside and bench.
abstract: Although significant contributions to the understanding of metabolic alkalosis have been made recently, much of our knowledge rests on data from clearance studies performed in humans and animals many years ago. This article reviews the contributions of these studies, as well as more recent work relating to the control of renal acid-base transport by mineralocorticoid hormones, angiotensin, endothelin, nitric oxide, and potassium balance. Finally, clinical aspects of metabolic alkalosis are considered.
authors.affiliation: Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, TX 79413, USA. melvin.laski@ttuhsc.edu
authors.forename: Melvin E
authors.initials: ME
authors.lastname: Laski
authors.forename: Sandra
authors.initials: S
authors.lastname: Sabatini
mesh_terms: D000450:Aldosterone / Q000378:metabolism; D000471:Alkalosis / Q000175:diagnosis / Q000209:etiology / Q000378:metabolism; D000809:Angiotensins / Q000378:metabolism; D000818:Animals; D001692:Biological Transport / Q000502:physiology; D018450:Disease Progression; D016232:Endothelins / Q000378:metabolism; D006801:Humans; D007674:Kidney Diseases / Q000150:complications* / Q000378:metabolism; D007684:Kidney Tubules / Q000378:metabolism; D011379:Prognosis; D012131:Respiratory Insufficiency / Q000150:complications* / Q000378:metabolism
chemical_list: D000809:Angiotensins; D016232:Endothelins; D000450:Aldosterone