The angiotensin II type 2 receptor gene polymorphism and body mass index in healthy Japanese women.
BACKGROUND
Angiotensin II (AngII), through the AngII type 2 receptor (AT2-R), might exert some effect on adipocyte- and lipogenesis-related biology. The Adenine/Cytosine 3123 (A/C(3123)) polymorphism in the AT2-R gene is reportedly involved in some diseases, such as hypertension.


METHODS
A total of 201 healthy Japanese women (mean age 43.2 years) were enrolled in the study to investigate the association among the AT2-R A/C(3123) polymorphism detected by polymerase chain reaction methods, body mass index (BMI) and other obesity-linked metabolic parameters (blood pressure, serum lipid/lipoprotein, plasma glucose).


RESULTS
Homozygotes of the C-allele in the AT2-R A/C(3123) polymorphism were associated with small but significant increases in BMI levels. There were no differences between genotype-based groups in the obesity-linked metabolic parameters.


CONCLUSIONS
These findings suggest that the AT2-R A/C(3123) polymorphism could be a polymorphic marker related to BMI in Japanese women.
Kotani
Kazuhiko
K
Division of Health Administration and Promotion, Faculty of Medicine, Tottori University, 86 Nishi-cho, Yonago 683-8503, Japan. kakotani@grape.med.tottori-u.ac.jp
Sakane
Naoki
N
Saiga
Kyoko
K
Tsuzaki
Kokoro
K
Sano
Yoshiko
Y
Mu
Haosheng
H
Kurozawa
Youichi
Y
D000328:Adult; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D015992:Body Mass Index; D005260:Female; D005819:Genetic Markers; D006801:Humans; D007564:Japan; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D044139:Receptor, Angiotensin, Type 2 / Q000235:genetics*
D005819:Genetic Markers; D044139:Receptor, Angiotensin, Type 2