title: Antidepressant-associated changes in semen parameters.
abstract: We describe 2 cases of patients referred for evaluation of male infertility who had antidepressant medication-associated changes in sperm motility and/or concentration. The physical examination and endocrinologic study findings were unremarkable in each case. Analysis of the initial semen specimens revealed oligospermia, impaired motility, and abnormal morphology in each patient while they were taking serotonin reuptake inhibitors. Repeat semen analyses performed 1 to 2 months after discontinuation of the antidepressants demonstrated marked improvements in sperm concentration and motility. Additional assessment of the potential impact of antidepressant medications on male fertility is warranted.
authors.affiliation: James Buchanan Brady Foundation, Department of Urology, New York-Presbyterian Hospital/Weill Medical College of Cornell University, New York, New York 10021, USA. cot2002@med.cornell.edu
authors.forename: Cigdem
authors.initials: C
authors.lastname: Tanrikut
authors.forename: Peter N
authors.initials: PN
authors.lastname: Schlegel
mesh_terms: D000328:Adult; D000928:Antidepressive Agents / Q000009:adverse effects* / Q000494:pharmacology*; D006801:Humans; D007248:Infertility, Male / Q000139:chemically induced*; D008297:Male; D013076:Sperm Count; D013081:Sperm Motility / Q000187:drug effects*
chemical_list: D000928:Antidepressive Agents