title: [Evaluation of specific activity of preparations of allergens from synanthropic insects].
abstract: Physical, chemical and immunobiological characteristics of allergens from synanthropic insects were studied by tests for anaphylaxis, indirect degranulation of mast cells test and ELISA. Sera from 20 patients with severe and intermediate atopic asthma with sensiblization to common allergens have been studied. All extracts of allergens from synanthropic insects (german cockroach, oriental cockroach, american cockroach, speckled feeder cockroach, cricket, common house fly, brown house moth, confused flour beetle, rice weevil, grain weevil) have specific activity. Extracts of allergens from common house fly, brown house moth, german cockroach and oriental cockroach had the strongest allergenic activity as measured by ELISA. Obtained allergens can be used for insect allergy diagnostics.
authors.forename: V M
authors.initials: VM
authors.lastname: Berzhets
authors.forename: O V
authors.initials: OV
authors.lastname: Radikova
authors.forename: S V
authors.initials: SV
authors.lastname: Khlgatian
authors.forename: A I
authors.initials: AI
authors.lastname: Berzhets
authors.forename: I S
authors.initials: IS
authors.lastname: Kropotova
mesh_terms: D000485:Allergens / Q000009:adverse effects* / Q000276:immunology* / Q000302:isolation & purification; D000707:Anaphylaxis / Q000139:chemically induced; D000818:Animals; D000918:Antibody Specificity; D001249:Asthma / Q000097:blood; D015550:Cell Degranulation / Q000276:immunology; D006168:Guinea Pigs; D006801:Humans; D006967:Hypersensitivity / Q000175:diagnosis; D007073:Immunoglobulin E / Q000097:blood / Q000276:immunology; D019476:Insect Proteins / Q000009:adverse effects* / Q000276:immunology* / Q000302:isolation & purification; D007313:Insecta / Q000276:immunology*; D008297:Male; D008407:Mast Cells / Q000276:immunology; D051381:Rats
chemical_list: D000485:Allergens; D019476:Insect Proteins; D007073:Immunoglobulin E