title: Experimental elicitation with hydroxyisohexyl-3-cyclohexene carboxaldehyde-containing deodorants.
abstract: Hydroxyisohexyl-3-cyclohexene carboxaldehyde (HICC) known as Lyral is a frequent allergen. It is used in more than 50% of marketed deodorants. The aim of the present study was to determine elicitation thresholds for HICC under simulated conditions of deodorant use. 15 patients with previously diagnosed contact allergy to HICC were patch tested with 5 solutions of HICC-scented and HICC-unscented deodorants. Patients and 10 healthy controls performed a use test in the axillae using deodorants scented with HICC in increasing concentrations and unscented deodorants as control. The concentration of HICC was increased every second week (200, 600, and 1800 p.p.m.) until either a reaction developed or for 6 weeks. 14 patients completed the study, and all developed unilateral eczema from the HICC-containing deodorant, while controls were all negative (P= 0.004). In 9/14 patients, a positive use test developed during the first 2 weeks to the deodorant containing 200 p.p.m. HICC. Positive correlations were found between the day of positive use and patch test threshold concentration of the HICC solutions (r= 0.71, P= 0.01) as well as the patch test thresholds of the HICC-scented deodorants (r= 0.74, P= 0.007). In conclusion, HICC elicits allergic contact dermatitis in a high proportion of sensitized individuals at common usage concentrations in deodorants.
authors.affiliation: National Allergy Research Center, Department of Dermatology, Gentofte Hospital, University of Copenhagen, Denmark.
authors.forename: Pia Haslund
authors.initials: PH
authors.lastname: Jørgensen
authors.forename: Charlotte Devantier
authors.initials: CD
authors.lastname: Jensen
authors.forename: Suresh
authors.initials: S
authors.lastname: Rastogi
authors.forename: Klaus Ejner
authors.initials: KE
authors.lastname: Andersen
authors.forename: Jeanne Duus
authors.initials: JD
authors.lastname: Johansen
mesh_terms: D000328:Adult; D000447:Aldehydes / Q000009:adverse effects*; D000485:Allergens / Q000009:adverse effects*; D003509:Cyclohexanecarboxylic Acids / Q000009:adverse effects*; D053138:Cyclohexenes / Q000009:adverse effects*; D003836:Deodorants / Q000009:adverse effects*; D017449:Dermatitis, Allergic Contact / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010328:Patch Tests; D018570:Risk Assessment; D020711:Threshold Limit Values
chemical_list: D000447:Aldehydes; D000485:Allergens; D003509:Cyclohexanecarboxylic Acids; D053138:Cyclohexenes; D003836:Deodorants; C004706:3-cyclohexene-1-carboxylic acid; C092244:hydroxyisohexyl 3-cyclohexene carboxaldehyde