Circadian rhythms in the CNS and peripheral clock disorders: function of clock genes: influence of medication for bronchial asthma on circadian gene.
Bronchial asthma is a chronic inflammatory disorder of the airways, in which inflammation causes bronchial hyper-responsiveness and flow limitation in the presence of various stimuli. Pulmonary function in asthmatic patients frequently deteriorates between midnight and early morning, which has suggested a role for chronotherapy. Although relationships between bronchial asthma and the function of clock genes remain unclear, some medications given for asthma such as glucocorticoids or beta(2)-adrenoceptor agonists may influence clock genes in vivo. In our studies of clock gene mRNA expressions in human bronchial epithelial cells in vitro and peripheral blood cells in vivo, we demonstrated that glucocorticoid or beta(2)-adrenoceptor agonist treatment strongly induced human Per1 mRNA expression both in vitro and in vivo. Human peripheral blood cells provide a useful indication of peripheral clock gene mRNA expression in vivo.
Burioka
Naoto
N
Division of Medical Oncology and Molecular Respirology, Faculty of Medicine, Tottori University, 36-1 Nishimachi, Yonago 683-8504, Japan. burioka@grape.med.tottori-u.ac.jp
Fukuoka
Yasushi
Y
Takata
Miyako
M
Endo
Masahiro
M
Miyata
Masanori
M
Chikumi
Hiroki
H
Tomita
Katsuyuki
K
Kodani
Masahiro
M
Touge
Hirokazu
H
Takeda
Kenichi
K
Sumikawa
Takashi
T
Yamaguchi
Kousuke
K
Ueda
Yasuto
Y
Nakazaki
Hirofumi
H
Suyama
Hisashi
H
Yamasaki
Akira
A
Sano
Hiroyuki
H
Igishi
Tadashi
T
Shimizu
Eiji
E
D000818:Animals; D001249:Asthma / Q000235:genetics* / Q000503:physiopathology*; D001683:Biological Clocks / Q000235:genetics* / Q000502:physiology*; D002490:Central Nervous System / Q000502:physiology*; D002940:Circadian Rhythm / Q000235:genetics* / Q000502:physiology*; D006801:Humans; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D018343:Receptors, Adrenergic, beta-2 / Q000235:genetics / Q000502:physiology
D012333:RNA, Messenger; D018343:Receptors, Adrenergic, beta-2