title: Human biomonitoring system in the Czech Republic.
abstract: The human biomonitoring (HBM) is an integral part of Environmental Health Monitoring System in the Czech Republic since 1994. Selected biomarkers of the internal dose (heavy metals, PCBs) and cytogenetic analysis of peripheral lymphocytes as a biomarker of the exposure/effect to/of environmental genotoxic factors are systematically followed up in the blood and urine of adults (blood donors), in children aged 8 to 10 years, and in the breast milk of nursing mothers. Selected outputs documented the declining trend of blood lead levels, with the recent reference value of 80 mg/l for men, and the rising trend of blood selenium levels in adults, but not in children. PCBs and chlorinated pesticides in human milk show a long-term downward trend, but still higher than in neighbouring countries. The frequency of aberrant cells revealed a downward trend, but the increase obtained in the last monitored period needs to be explained. Further HBM activities are required to demonstrate the corresponding trends and to reduce human exposure and health risks.
authors.affiliation: National Institute of Public Health, Centre of Environmental Health, Srobárova 48, 10042 Prague 10, Czech Republic. mcerna@szu.cz
authors.forename: Milena
authors.initials: M
authors.lastname: Cerná
authors.forename: Vĕra
authors.initials: V
authors.lastname: Spĕvácková
authors.forename: Andrea
authors.initials: A
authors.lastname: Batáriová
authors.forename: Jirí
authors.initials: J
authors.lastname: Smíd
authors.forename: Mája
authors.initials: M
authors.lastname: Cejchanová
authors.forename: Dana
authors.initials: D
authors.lastname: Ocadlíková
authors.forename: Hana
authors.initials: H
authors.lastname: Bavorová
authors.forename: Bohuslav
authors.initials: B
authors.lastname: Benes
authors.forename: Růzena
authors.initials: R
authors.lastname: Kubínová
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D002869:Chromosome Aberrations / Q000139:chemically induced*; D018153:Czech Republic / Q000453:epidemiology; D004781:Environmental Exposure; D004782:Environmental Health; D004784:Environmental Monitoring / Q000379:methods*; D062665:Epidemiological Monitoring; D005260:Female; D006801:Humans; D008297:Male; D019216:Metals, Heavy / Q000097:blood / Q000652:urine; D008875:Middle Aged; D008895:Milk, Human / Q000737:chemistry*; D011078:Polychlorinated Biphenyls / Q000097:blood / Q000652:urine; D011159:Population Surveillance; D018570:Risk Assessment
chemical_list: D019216:Metals, Heavy; D011078:Polychlorinated Biphenyls