Violent persons with schizophrenia and comorbid disorders: a functional magnetic resonance imaging study.
The main goal of this functional Magnetic Resonance Imaging (fMRI) study was to verify the hypothesis that seriously violent persons with Sz and the co-morbid diagnoses of an Antisocial Personality Disorder (APD) and a Substance Use Disorder (Sz+APD+SUD) would present a different pattern of prefrontal functioning than seriously violent persons with Sz only. In support with the main hypothesis, frontal basal cortices were significantly less activated in persons with Sz+APD+SUD during the execution of a go/no-go task than in persons with Sz only and non-violent persons without a mental illness. In contrast, significantly higher activations in frontal motor, premotor and anterior cingulate regions were observed in the Sz+APD+SUD group than in the Sz-only group.
Joyal
C C
CC
Niuvanniemi Hospital, Kuopio, Finland. christian.joyal@uqtr.ca
Putkonen
A
A
Mancini-Marïe
A
A
Hodgins
S
S
Kononen
M
M
Boulay
L
L
Pihlajamaki
M
M
Soininen
H
H
Stip
E
E
Tiihonen
J
J
Aronen
H J
HJ
D000328:Adult; D000987:Antisocial Personality Disorder / Q000175:diagnosis / Q000453:epidemiology* / Q000523:psychology; D001921:Brain / Q000503:physiopathology*; D015897:Comorbidity; D017831:Diagnosis, Dual (Psychiatry); D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D017397:Prefrontal Cortex / Q000503:physiopathology; D012559:Schizophrenia / Q000453:epidemiology* / Q000503:physiopathology; D012720:Severity of Illness Index; D019966:Substance-Related Disorders / Q000175:diagnosis / Q000453:epidemiology*; D014754:Violence / Q000523:psychology* / Q000706:statistics & numerical data*