Metabolite concentrations of healthy mouse brain by Magnetic Resonance Spectroscopy at 7 Tesla.
In vivo1H short echo-time Magnetic Resonance spectra are made up of overlapping spectral components from many metabolites. Typically, they exibit low signal-to-noise ratio. Metabolite concentrations are obtained by quantitating such spectra. Quantitation is difficult due to the superposition of metabolite resonances, macromolecules, lipids and water residue contributions. A fitting algorithm invoking extensive prior knowledge is needed. We quantitated1H in vivo mouse brain spectra obtained at 7 Tesla using the time-domain QUEST method combined with in vitro metabolite basis set signals. Brain metabolite concentrations estimated from eight mouse brain signals are compared to previously reported results.
Cudalbu
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Laboratoire de RMN, CNRS UMR 5012, Université Claude Bernard LYON I, CPE, Domaine Scientifique de la DOUA, 43 Boulevard du 11 Novembre 1918, 69616 Villeurbanne Cedex, France.
Cavassila
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Ratiney
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Beuf
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Briguet
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Graveron-Demilly
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