The effect of cinnamon extract on insulin resistance parameters in polycystic ovary syndrome: a pilot study.
Cinnamon extract has been shown to reduce insulin resistance in in vitro and in vivo studies by increasing phosphatidylinositol 3-kinase activity in the insulin signaling pathway and thus potentiating insulin action. Fifteen women with polycystic ovary syndrome (PCOS) were randomized to daily oral cinnamon and placebo for 8 weeks. Comparisons of post-treatment to baseline insulin sensitivity indices using fasting and 2-hour oral glucose tolerance tests showed significant reductions in insulin resistance in the cinnamon group but not in the placebo group. A larger trial is needed to confirm the findings of this pilot study and to evaluate the effect of cinnamon extract on menstrual cyclicity.
Wang
Jeff G
JG
Department of Obstetrics & Gynecology, Division of Reproductive Endocrinology, College of Physicians & Surgeons, Columbia University, New York, New York 10023, USA. jw781@columbia.edu
Anderson
Richard A
RA
Graham
George M
GM
Chu
Micheline C
MC
Sauer
Mark V
MV
Guarnaccia
Michael M
MM
Lobo
Rogerio A
RA
D000328:Adult; D002935:Cinnamomum zeylanicum; D005260:Female; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D010865:Pilot Projects; D010936:Plant Extracts / Q000627:therapeutic use; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000188:drug therapy*
D010936:Plant Extracts