[Prognostic value of some serological markers of rheumatoid arthritis in assessment of x-ray outcome of the disease].
OBJECTIVE
To specify significance of some serological markers for diagnosis and x-ray prognosis of rheumatoid arthritis (RA).


METHODS
A total of 115 RA patients with the disease history not longer than 4 years were examined for serum antibodies to cyclic citrullated peptide (ACCP), rheumatoid factor (RF), antikeratine antibodies (AKA) using enzyme immunoassay and indirect immunofluorescence.


RESULTS
ACCP, AKA, IgA-RF, IgM-RF were detected in 79.15%, 47.8%, 64.3%, 89.6% patients, respectively. ACCP was found to be directly correlated with negative x-ray changes in hand and foot joints. ACCP specificity reached 97%, the highest specificity (up to 100%) being in determination of RF and ACCP.


CONCLUSIONS
ACCP is an independent factor increasing significance of x-ray indices and thus allowing prognosis of x-ray outcome of RA.
Redaĭtene
E
E
Stropuvene
S
S
Dadonene
I
I
Kidraĭte
G
G
Lapinene
G
G
D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000097:blood* / Q000000981:diagnostic imaging* / Q000276:immunology; D001175:Arthrography; D001323:Autoantibodies / Q000097:blood* / Q000276:immunology; D015415:Biomarkers / Q000097:blood; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007633:Keratins / Q000276:immunology; D008297:Male; D008875:Middle Aged; D010456:Peptides, Cyclic / Q000276:immunology; D011237:Predictive Value of Tests; D012217:Rheumatoid Factor / Q000276:immunology; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index
D001323:Autoantibodies; D015415:Biomarkers; D010456:Peptides, Cyclic; C487763:cyclic citrullinated peptide; D007633:Keratins; D012217:Rheumatoid Factor