title: Metabolite concentrations of healthy mouse brain by Magnetic Resonance Spectroscopy at 7 Tesla.
abstract: In vivo1H short echo-time Magnetic Resonance spectra are made up of overlapping spectral components from many metabolites. Typically, they exibit low signal-to-noise ratio. Metabolite concentrations are obtained by quantitating such spectra. Quantitation is difficult due to the superposition of metabolite resonances, macromolecules, lipids and water residue contributions. A fitting algorithm invoking extensive prior knowledge is needed. We quantitated1H in vivo mouse brain spectra obtained at 7 Tesla using the time-domain QUEST method combined with in vitro metabolite basis set signals. Brain metabolite concentrations estimated from eight mouse brain signals are compared to previously reported results.
authors.affiliation: Laboratoire de RMN, CNRS UMR 5012, Université Claude Bernard LYON I, CPE, Domaine Scientifique de la DOUA, 43 Boulevard du 11 Novembre 1918, 69616 Villeurbanne Cedex, France.
authors.forename: C
authors.initials: C
authors.lastname: Cudalbu
authors.forename: S
authors.initials: S
authors.lastname: Cavassila
authors.forename: H
authors.initials: H
authors.lastname: Ratiney
authors.forename: O
authors.initials: O
authors.lastname: Beuf
authors.forename: A
authors.initials: A
authors.lastname: Briguet
authors.forename: D
authors.initials: D
authors.lastname: Graveron-Demilly