[Exposure of Tenon's capsule fibroblasts of pterygium to cyclosporin 0.05%].
OBJECTIVE
To evaluate normal Tenon capsule fibroblasts and from pterygia in culture when exposed to cyclosporin 0.05%.


METHODS
A prospective, randomized study was done, involving 20 patients with primary pterygium. Samples of normal and pterygium Tenon's capsule from the same individual were collected, cultured and exposed to cyclosporin 0.05%.


RESULTS
Only 7 samples could be exposed to cyclosporin--6 from pterygial Tenon's capsule and 1 from normal Tenon's capsule. There was a significant reduction of cellular proliferation in the cyclosporin exposed cultures (p<0.05).


CONCLUSIONS
Cyclosporin 0.05% is effective to inhibit the proliferation of pterygia and normal Tenon's capsule fibroblasts. Further studies should be performed to define the role of cyclosporin in pterygium treatment.
Hercules
Laura Almeida
LA
Departamento de Oftalmologia, Otorrinolaringologia e Cirurgia de Cabeça e Pescoço, Faculdade de Medicina de Botucatu, Universidade Estadual Paulista Júlio Mesquita Filho, Botucatu, SP, Brazil.
Viveiros
Magda Massae Hata
MM
Schellini
Silvana Artioli
SA
Candeias
João
J
Padovani
Carlos Roberto
CR
D000704:Analysis of Variance; D002452:Cell Count / Q000379:methods; D002478:Cells, Cultured; D016572:Cyclosporine / Q000494:pharmacology*; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects*; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D011446:Prospective Studies; D011625:Pterygium / Q000473:pathology* / Q000601:surgery; D018709:Statistics, Nonparametric; D013997:Time Factors
D007166:Immunosuppressive Agents; D016572:Cyclosporine