Chk1: a double agent in cell cycle checkpoints.
Two cell cycle surveillance systems--the DNA damage checkpoint and the spindle checkpoint--guard against genomic instability. The protein kinase Chk1 is a well-established signal transducer in the DNA damage checkpoint. In this issue of Developmental Cell, Zachos et al.(2007) present evidence to indicate that Chk1 also plays a critical role in the spindle checkpoint, suggesting an interplay between the DNA damage and spindle checkpoints.
Yu
Hongtao
H
Department of Pharmacology, University of Texas Southwestern Medical Center, 6001 Forest Park Road, Dallas, TX 75390, USA. hongtao.yu@utsouthwestern.edu
D000818:Animals; D064127:Aurora Kinases; D002453:Cell Cycle; D000071877:Checkpoint Kinase 1; D002645:Chickens; D020090:Chromosome Segregation / Q000187:drug effects / Q000235:genetics; D006801:Humans; D018386:Kinetochores / Q000187:drug effects / Q000201:enzymology; D017239:Paclitaxel / Q000494:pharmacology; D010766:Phosphorylation / Q000187:drug effects; D011494:Protein Kinases / Q000172:deficiency / Q000378:metabolism*; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism
D011494:Protein Kinases; D064127:Aurora Kinases; C000605867:CHEK1 protein, human; D000071877:Checkpoint Kinase 1; D017346:Protein Serine-Threonine Kinases; D017239:Paclitaxel