Predicting protein secondary structure using continuous wavelet transform and Chou-Fasman method.
Secondary structure of a protein can be predicted efficiently by combining continuous wavelet transform (CWT) and Chou-Fasman method. We selected a protein with ID 1gca from PDB database, and substitute every amino acid of the protein with corresponding hydrophobic value. Then CWT was used to get the nucleated residues of certain type of secondary structure. The regions were extended along the protein sequence in each direction based on Chou-Fasman rules. The prediction accuracy for ..-helix, ..-sheet (regular secondary structures), loop (irregular secondary structure) is 80.57%, 75.41%, and 92.31%, respectively.
Chen
Hang
H
Department of Biotechnology, Zhejiang University, Hangzhou 310027, P. R. China.
Gu
Fei
F
Liu
Feng
F