title: Predictive values of transcutaneous oxygen tension for above-the-ankle amputation in diabetic patients with critical limb ischemia.
abstract: OBJECTIVE
  To assess the values of transcutaneous oxygen tension (TcPO2) capable of predicting above-the-ankle amputation in diabetic patients diagnosed for critical limb ischemia (CLI) according to the criteria of the TransAtlantic Inter-Society Consensus.
  
  
  METHODS
  Retrospective study.
  
  
  METHODS
  From January 1999 to December 2003, 564 diabetic patients were consecutively hospitalized for CLI in one limb. Revascularization with angioplasty or bypass graft was performed when possible and, if not possible, prostanoid therapy was used. In patients in whom therapies did not relieve the rest pain or the gangrene was extended above the Chopart joint, an above-the-ankle-amputation was performed. After treatment TcPO2 values were evaluated in all patients at the dorsum of the foot.
  
  
  RESULTS
  Fifty-five (9.8%) patients underwent an above-the-ankle amputation: 22 of 420 patients who underwent angioplasty, 17 of 117 patients who underwent bypass (14.5%) and 16 of 27 patients in whom revascularization was not possible. Post-treatment TcPO2, measured by a receiver operating characteristic (ROC) curve, showed a value 34 mmHg as the best threshold for determining the need for revascularization, with an area under the curve of 0.89 (95%CI 0.85-0.94). Using logistic regression analysis the probability of above-the-ankle amputation for this threshold is 9.7% and reduces to 3% for TcPO2 > 40 mmHg.
  
  
  CONCLUSIONS
  TcPO2 levels<34 mmHg indicate the need for revascularization, while for values >or= 34 < 40 mmHg this need appears less pressing, although there remains a considerable probability of amputation. TcPO2 levels greater than 40 mmHg suggest that revascularization is dependent on the severity of tissue loss and possible morbidity caused by the procedure.
authors.affiliation: Diabetology Center-Diabetic Foot Center, IRCCS Multimedica, Sesto San Giovanni, Milano, Italy. ezio.faglia@multimedica.it
authors.forename: E
authors.initials: E
authors.lastname: Faglia
authors.forename: G
authors.initials: G
authors.lastname: Clerici
authors.forename: M
authors.initials: M
authors.lastname: Caminiti
authors.forename: A
authors.initials: A
authors.lastname: Quarantiello
authors.forename: V
authors.initials: V
authors.lastname: Curci
authors.forename: A
authors.initials: A
authors.lastname: Morabito
mesh_terms: D000368:Aged; D000671:Amputation, Surgical / Q000379:methods*; D000842:Ankle; D001785:Blood Gas Monitoring, Transcutaneous; D017719:Diabetic Foot / Q000097:blood / Q000150:complications* / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007511:Ischemia / Q000097:blood* / Q000209:etiology / Q000601:surgery; D008297:Male; D011184:Postoperative Period; D011237:Predictive Value of Tests; D012372:ROC Curve; D012189:Retrospective Studies; D012720:Severity of Illness Index; D016896:Treatment Outcome