Modulation of innate and adaptive immunity by lactoferrin in human immunodeficiency virus (HIV)-infected, antiretroviral therapy-naïve children.
Oral lactoferrin supplementation in human immunodeficiency virus (HIV)-infected, antiretroviral therapy-naïve children resulted in a skewing of T-lymphocytes towards more differentiated subpopulations. Phagocytosis (P=0.01) and killing (P=0.009), Toll-like receptor 2 expression (P=0.01) and the interleukin-12/interleukin-10 ratio (P=0.001) were also improved by lactoferrin. Lactoferrin supplementation results in immune modulation and could be useful in HIV infection.
Zuccotti
Gian Vincenzo
GV
Paediatrics, University of Milan, Milan, Italy.
Vigano
Alessandra
A
Borelli
Manuela
M
Saresella
Marina
M
Giacomet
Vania
V
Clerici
Mario
M
D000284:Administration, Oral; D000293:Adolescent; D000818:Animals; D019380:Anti-HIV Agents / Q000008:administration & dosage; D002417:Cattle; D002648:Child; D002675:Child, Preschool; D015658:HIV Infections / Q000188:drug therapy* / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate / Q000187:drug effects*; D007781:Lactoferrin / Q000008:administration & dosage*; D016176:T-Lymphocyte Subsets / Q000187:drug effects / Q000276:immunology
D019380:Anti-HIV Agents; D007781:Lactoferrin