title: [Time dependency of factors influencing survival of hepatocellular carcinoma patients with portal vein tumor thrombosis after surgery].
abstract: OBJECTIVE
  To investigate the surgical outcome of the hepatocellular carcinoma (HCC) patients with portal vein tumor thrombosis (PVTT) after surgery and the time-dependency of the factors influencing survival.
  
  
  METHODS
  The clinicopathological data of 382 HCC patients with macroscopic PVTT who had undergone resection of HCC were analyzed. The survival rte was calculated using Kaplan-Meier method. Stratified Cox model was used to identify the factors independently influencing the short- and long-term survival rates.
  
  
  RESULTS
  The 1-, 2-, 3-, 5-, and 10-year survival rates of the 382 patients were 47%, 23%, 16%, 12%, and 6% respectively. The 1-, 3-, and 5-year survival rates re-calculated from the time of re-resection because of recurrence within 2 years after the first operation were 36%, 14%, and 0% 1 respectively. However, the 1-, 3-, and 5-year survival rates re-calculated from the time of re-resection because of recurrence 2 years after the first operation were 85%, 53%, and 32%, all significantly higher than those re-calculated from the time of re-resection within 2 years after the first operation (all P < 0.05). Multivariate analysis showed that portal infusion chemotherapy, serum alpha-fetoprotein < 20 microg/L and negative surgical margin were significant favorable prognostic factors within 2 years after operation. Alanine aminotransferase > 80 U/L was the only significant unfavorable factor beyond 2 years after operation.
  
  
  CONCLUSIONS
  The prognosis of the patients with macroscopic PVTT who suffer from liver tumor recurrence occurring more than 2 years after the first operation is much better than those with the recurrence occurring within 2 years. Evaluation of the time-dependency of risk factors may have important clinical implication in determining the therapeutic strategy.
authors.affiliation: Liver Cancer Institute, Zhongshan Hospital, Fudam University, Shanghai 200032, China. jianzhou@zshospital.net
authors.forename: Jian
authors.initials: J
authors.lastname: Zhou
authors.forename: Jia
authors.initials: J
authors.lastname: Fan
authors.forename: Zhao-you
authors.initials: ZY
authors.lastname: Tang
authors.forename: Zhi-quan
authors.initials: ZQ
authors.lastname: Wu
authors.forename: Xin-da
authors.initials: XD
authors.lastname: Zhou
authors.forename: Zeng-chen
authors.initials: ZC
authors.lastname: Ma
authors.forename: Chang-jun
authors.initials: CJ
authors.lastname: Tan
authors.forename: Ying-hong
authors.initials: YH
authors.lastname: Shi
authors.forename: Yao
authors.initials: Y
authors.lastname: Yu
authors.forename: Shuang-jian
authors.initials: SJ
authors.lastname: Qiu
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006498:Hepatectomy / Q000009:adverse effects / Q000379:methods / Q000706:statistics & numerical data; D006801:Humans; D053208:Kaplan-Meier Estimate; D008113:Liver Neoplasms / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009360:Neoplastic Cells, Circulating / Q000473:pathology; D011169:Portal Vein; D011184:Postoperative Period; D011379:Prognosis; D016016:Proportional Hazards Models; D012044:Regression Analysis; D015996:Survival Rate; D013997:Time Factors; D020246:Venous Thrombosis / Q000209:etiology / Q000473:pathology*