title: Intraoperative neurological changes in 1665 regional anaesthetic carotid endarterectomies predicts postoperative stroke.
abstract: BACKGROUND
  To maximize the benefit of carotid endarterectomy (CEA) in stroke prevention its complication rate must be minimized. The purpose of this study was to report the outcomes of a large series of CEA carried out under regional anaesthesia with selective shunting, with particular emphasis on identifying predictors for perioperative stroke and mortality.
  
  
  METHODS
  Between 1987 and 2003 the data for 1665 consecutive regional anaesthetic CEA carried out in 1495 patients were collected prospectively; awake neurological testing facilitated selective shunting. Preoperative data, intraoperative events and postoperative in-hospital complications were recorded and analysed.
  
  
  RESULTS
  There were 38 non-fatal strokes (2.3%) and 10 deaths (0.6%), giving a combined stroke and mortality rate of 2.9%. Only patients who needed shunting were found to have significantly higher rate of postoperative stroke and mortality (7.0 vs 1.9%, P < 0.001). Patient characteristics, comorbidities, indication for operation (P = 0.34) and the degree of stenosis of the contralateral carotid artery (P = 0.65) were not found to be predictive of perioperative stroke or mortality, although the latter two were found to be predictive of the need for shunting (P < 0.001 and P = 0.002).
  
  
  CONCLUSIONS
  Regional anaesthetic CEA is a safe and effective technique with excellent morbidity and mortality rates. The technique can be undertaken safely regardless of the indication for endarterectomy or the status of the contralateral carotid artery. Patients who developed intraoperative neurological changes requiring shunting are identified as high risk for perioperative stroke or mortality and should therefore be carefully monitored postoperatively.
authors.affiliation: Department of Vascular Surgery, University of Melbourne, St Vincent's Hospital, Melbourne, Victoria, Australia.
authors.forename: Raoul C
authors.initials: RC
authors.lastname: Mayer
authors.forename: John
authors.initials: J
authors.lastname: Bingley
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Westcott
authors.forename: Arvind
authors.initials: A
authors.lastname: Deshpande
authors.forename: Micheal J
authors.initials: MJ
authors.lastname: Davies
authors.forename: Mark E
authors.initials: ME
authors.lastname: Lovelock
authors.forename: John
authors.initials: J
authors.lastname: Vidovich
authors.forename: John
authors.initials: J
authors.lastname: Doyle
authors.forename: Micheal J
authors.initials: MJ
authors.lastname: Denton
authors.forename: John F
authors.initials: JF
authors.lastname: Gurry
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000765:Anesthesia, Conduction; D016893:Carotid Stenosis / Q000601:surgery; D016894:Endarterectomy, Carotid / Q000009:adverse effects* / Q000379:methods / Q000401:mortality*; D005260:Female; D006801:Humans; D007431:Intraoperative Complications; D007432:Intraoperative Period; D008297:Male; D008875:Middle Aged; D009422:Nervous System Diseases / Q000209:etiology; D020521:Stroke / Q000209:etiology* / Q000517:prevention & control