title: A radical role for p38 MAPK in tumor initiation.
abstract: It is established that p38 MAPK can negatively regulate tumorigenesis, but the mechanism is incompletely understood. A new study in this issue of Cancer Cell shows that p38 MAP kinase plays a selective role in tumor initiation mediated by oxidative stress.
authors.affiliation: Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.
authors.forename: Norman J
authors.initials: NJ
authors.lastname: Kennedy
authors.forename: Cristina
authors.initials: C
authors.lastname: Cellurale
authors.forename: Roger J
authors.initials: RJ
authors.lastname: Davis
mesh_terms: D000818:Animals; D017209:Apoptosis; D002471:Cell Transformation, Neoplastic; D006801:Humans; D048308:Mitogen-Activated Protein Kinase 14 / Q000235:genetics / Q000502:physiology*; D009369:Neoplasms / Q000201:enzymology* / Q000473:pathology; D018384:Oxidative Stress; D017382:Reactive Oxygen Species / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D017382:Reactive Oxygen Species; D048308:Mitogen-Activated Protein Kinase 14