Adulteration of mustard cooking oil with argemone oil: do Indian food regulatory policies and antioxidant therapy both need revisitation?
Consumption of adulterated mustard oil (Brassica nigra) with argemone oil (Argemone mexicana) even for a short duration leads to a clinical condition referred as epidemic dropsy. In humans, argemone oil contained in adulterated mustard oil causes oxidative stress and death of red blood cells via met-hemoglobin formation by altering pyridine nucleotide(s) and glutathione redox potential. Argemone oil contamination poses a serious threat to human health and should be checked by appropriate regulatory measures. Antioxidant therapy provides symptomatic relief and should be seriously considered for therapeutic interventions against argemone oil toxicity.
Babu
Challagundla Kishore
CK
Food Toxicology Laboratory, Industrial Toxicology Research Centre, Lucknow, India.
Khanna
Subhash Kumar
SK
Das
Mukul
M
D000975:Antioxidants / Q000627:therapeutic use*; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy*; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism; D019803:Glutathione Disulfide / Q000378:metabolism; D006801:Humans; D007194:India; D015227:Lipid Peroxidation / Q000187:drug effects; D008954:Models, Biological; D009149:Mustard Plant; D009243:NAD / Q000378:metabolism; D018673:Nutrition Policy; D010084:Oxidation-Reduction / Q000187:drug effects; D010938:Plant Oils / Q000008:administration & dosage*
D000975:Antioxidants; D010938:Plant Oils; C030610:argemone oil; D009243:NAD; D005978:Glutathione; C027793:mustard oil; D019803:Glutathione Disulfide