Metabolic disorders in patients with chronic kidney failure.
This review article summarizes the problems of metabolic disorders and nutrition imbalances that often occur in chronic kidney failure (CKF) or following regular dialysis treatment. In this survey, we cover the pathogenesis of these disorders, their clinical consequences, and their association with the most severe complications of chronic kidney failure and dialysis treatment. These complications are primarily atherosclerosis, malnutrition, anemia, hyperparathyroidism, and other serious problems that markedly and negatively affect prognosis and the quality of life of uremic patients. Risk factors for cardiovascular disease are discussed in-depth because cardiovascular disease is the leading cause of death in patients with chronic kidney failure. It is important to pay attention to the development of these complications because early diagnosis and therapy can improve the prognosis for these patients and reduce treatment costs.
Cibulka
R
R
Institute of Clinical Biochemistry and Hematology, Charles University, Faculty of Medicine, Pilsen, Czech Republic. cibulkar@fnplzen.cz
Racek
J
J
D000136:Acid-Base Equilibrium / Q000502:physiology; D000740:Anemia / Q000150:complications; D000818:Animals; D050260:Carbohydrate Metabolism / Q000502:physiology; D002318:Cardiovascular Diseases / Q000150:complications; D012080:Chronic Kidney Disease-Mineral and Bone Disorder / Q000150:complications; D006801:Humans; D020138:Hyperhomocysteinemia / Q000503:physiopathology; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000378:metabolism; D050356:Lipid Metabolism / Q000502:physiology; D008659:Metabolic Diseases / Q000209:etiology* / Q000378:metabolism; D018384:Oxidative Stress / Q000502:physiology; D011506:Proteins / Q000378:metabolism; D006435:Renal Dialysis / Q000009:adverse effects
D011506:Proteins