title: Outcomes in retinoblastoma, 1974-2005: the Children's Hospital, Westmead.
abstract: BACKGROUND
  To report the 31-year experience of outcomes in retinoblastoma from a single centre.
  
  
  METHODS
  A retrospective analysis of consecutive cases of retinoblastoma diagnosed and treated at the Westmead Children's Hospital, Sydney between 1974 and 2005 was performed. The subjects were analysed as two groups: those diagnosed between 1974 and 1989 (series alpha) and those diagnosed between 1990 and 2005 (series beta).
  
  
  RESULTS
  There were a total of 142 patients included in the study, with a median follow up of 72 months. There were 84 patients with unilateral disease and 58 patients (116 eyes) with bilateral disease. The total enucleation rate remained high throughout both series for those with unilateral disease: 89% (series alpha) and 95% (series beta). There was a reduction in enucleations performed for those with bilateral disease from 68.4% (series alpha) to 43.6% (series beta) (P < 0.025). There were no bilateral enucleations performed after 1995. Actuarial Kaplan-Meier curves showed that 56% of all preserved eyes had not recurred at a median follow up of 95 months and 78.1% had avoided enucleation. Overall 43% of preserved eyes attained a visual acuity better than or equal to 6/12 and 55% achieved a visual acuity better than 6/60. There were four deaths due to retinoblastoma. Five patients were diagnosed with a second non-ocular malignancy. The most common treatment-related complications were cataracts, facial deformity, sepsis and febrile neutropaenia.
  
  
  CONCLUSIONS
  The introduction of newer globe-preserving treatments for retinoblastoma was associated with equivalent visual outcomes, stable mortality rate and a greater number of short-term complications but avoided the late side-effects associated with external beam radiotherapy.
authors.affiliation: Department of Ophthalmology, The Children's Hospital, Westmead, New South Wales, Australia.
authors.forename: Edwina L
authors.initials: EL
authors.lastname: Berman
authors.forename: Craig E
authors.initials: CE
authors.lastname: Donaldson
authors.forename: Michael
authors.initials: M
authors.lastname: Giblin
authors.forename: Frank J
authors.initials: FJ
authors.lastname: Martin
mesh_terms: D001918:Brachytherapy; D017679:Cryotherapy; D018572:Disease-Free Survival; D015353:Eye Enucleation / Q000706:statistics & numerical data; D005260:Female; D005500:Follow-Up Studies; D006776:Hospitals, Pediatric / Q000706:statistics & numerical data*; D006801:Humans; D006979:Hyperthermia, Induced; D007223:Infant; D017075:Laser Coagulation; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy; D009517:New South Wales / Q000453:epidemiology; D019572:Retinal Neoplasms / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy*; D012175:Retinoblastoma / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy*; D012189:Retrospective Studies; D016896:Treatment Outcome; D014792:Visual Acuity