title: Metastatic carcinoma to the cervical nodes from an unknown head and neck primary site: Is there a need for neck dissection?
abstract: BACKGROUND
  The aim of the study was to evaluate the outcomes and patterns of failure in patients with metastatic carcinoma to cervical lymph nodes from an unknown head and neck primary origin, who were treated curatively with radiotherapy, with or without neck dissection.
  
  
  METHODS
  The study included 61 patients referred to the McGill University Hospital Centers from 1987 to 2002. The median age was 57 years, with male to female ratio of 4:1. Distribution of patients by N status was as follows: N1, 16 patients (26%); N2a, 18 (30%); N2b, 13 (22%); N2c, 7 (11%); and N3, 7 (11%). Twenty patients underwent neck dissection (11 radical, 9 functional) and 41 patients had biopsy (9 fine-needle aspiration and 32 excisional biopsy). All patients received radiotherapy. The median dose to the involved node(s) was 64 Gy, and 60 Gy to the rest of the neck. Treatment of the neck was bilateral in 50 patients (82%) and ipsilateral in 11 (18%). The minimum duration of the follow-up was 12 months, with the median of 32 months.
  
  
  RESULTS
  The 5- and 8-year overall survival for the whole population was 79% and 67%, respectively. There was no statistically significant difference in the 8-year actuarial overall survival (64.8% and 67.6%, respectively, p = .64) and local relapse-free survival (75% vs 74.5%, respectively, p = .57), among patients who had biopsy versus those who had neck dissection.
  
  
  CONCLUSIONS
  In our experience, definitive radiotherapy to the neck and the potential mucosal sites, whether preceded by neck dissection or not, is effective to achieve a good local control rate in the unknown primary cancer of the head and neck. The indication for neck dissection, in particular for early nodal stage, is controversial.
authors.affiliation: Department of Radiation Oncology, McGill University, Montreal, Quebec, Canada. aslani_m@yahoo.com
authors.forename: Maryam
authors.initials: M
authors.lastname: Aslani
authors.forename: Khalil
authors.initials: K
authors.lastname: Sultanem
authors.forename: Te
authors.initials: T
authors.lastname: Voung
authors.forename: Michael
authors.initials: M
authors.lastname: Hier
authors.forename: Tamim
authors.initials: T
authors.lastname: Niazi
authors.forename: George
authors.initials: G
authors.lastname: Shenouda
mesh_terms: D044963:Biopsy, Fine-Needle; D002277:Carcinoma / Q000401:mortality / Q000556:secondary* / Q000628:therapy*; D005260:Female; D006258:Head and Neck Neoplasms / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D015182:Lymphatic Irradiation; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D037981:Neck Dissection; D009382:Neoplasms, Unknown Primary / Q000473:pathology*; D011879:Radiotherapy Dosage; D016019:Survival Analysis