title: Malignant blue nevus: case report of a Japanese man with a distant cutaneous metastasis.
abstract: We report a 55-year-old Japanese patient with a malignant blue nevus (MBN) on the scalp. The patient had regional lymph nodes metastases at his first visit, and a distant cutaneous metastatic papule appeared on the back 1 year later despite therapeutic intervention. Histology of the primary tumor lacked a junctional component and showed a typically biphasic pattern in the degree of pigmentation similar to a cellular blue nevus (BN). One pattern showed nests of less-pigmented, oval-shaped cells with a fairly uniform appearance, and the other pattern showed an aggregation of spindle-shaped cells containing a large amount of melanin pigment intermingled with heavily pigmented melanophages. Histology of metastatic regional lymph nodes also showed a biphasic proliferative pattern of oval-shaped, pale cells and spindle-shaped, richly pigmented cells. A distant cutaneous metastatic papule on the back showed massive proliferation of atypically large, pale, and oval-shaped melanoma cells with heavily pigmented melanophages just beneath the uninvolved epidermis. These histologic features were different from those of metastatic tumor proliferation from conventional melanoma. It seems probable that MBN might maintain a different biological and histopathologic character from conventional melanoma when it grows in metastatic sites.
authors.affiliation: Department of Dermatology, Clinical Research Institute, National Sapporo Hospital, Sapporo, Japan. kato@sap-cc.go.jp
authors.forename: Naoko
authors.initials: N
authors.lastname: Kato
authors.forename: Ayumi
authors.initials: A
authors.lastname: Tamura
authors.forename: Yasuko
authors.initials: Y
authors.lastname: Yamanaka
authors.forename: Shintaro
authors.initials: S
authors.lastname: Tanimura
authors.forename: Hidehiko
authors.initials: H
authors.lastname: Minakawa
mesh_terms: D049109:Cell Proliferation; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D018329:Nevus, Blue / Q000175:diagnosis / Q000473:pathology*; D012535:Scalp / Q000473:pathology; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000175:diagnosis / Q000473:pathology*