title: The influence of selenium supplementation on postpartum thyroid status in pregnant women with thyroid peroxidase autoantibodies.
abstract: BACKGROUND
  Pregnant women who are positive for thyroid peroxidase antibodies [TPOAb(+)] are prone to develop postpartum thyroid dysfunction (PPTD) and permanent hypothyroidism. Selenium (Se) decreases thyroid inflammatory activity in patients with autoimmune thyroiditis.
  
  
  OBJECTIVE
  We examined whether Se supplementation, during and after pregnancy, influences the thyroidal autoimmune pattern and function.
  
  
  METHODS
  This was a prospective, randomized, placebo-controlled study.
  
  
  METHODS
  The study was conducted in the Department of Obstetrics and Gynecology and Department of Endocrinology.
  
  
  METHODS
  A total of 2143 euthyroid pregnant women participated in the study; 7.9% were TPOAb(+).
  
  
  METHODS
  During pregnancy and the postpartum period, 77 TPOAb(+) women received selenomethionine 200 microg/d (group S1), 74 TPOAb(+) women received placebo (group S0), and 81 TPOAb(-) age-matched women were the control group (group C).
  
  
  METHODS
  We measured the prevalence of PPTD and hypothyroidism.
  
  
  RESULTS
  PPTD and permanent hypothyroidism were significantly lower in group S1 compared with S0 (28.6 vs. 48.6%, P<0.01; and 11.7 vs. 20.3%, P<0.01).
  
  
  CONCLUSIONS
  Se supplementation during pregnancy and in the postpartum period reduced thyroid inflammatory activity and the incidence of hypothyroidism.
authors.affiliation: Department of Endocrinology, Azienda Ospedaliera LE/1, P.O. V. Fazzi, Piazza F. Muratore, 73100 Lecce, Italy. robnegro@tiscali.it
authors.forename: Roberto
authors.initials: R
authors.lastname: Negro
authors.forename: Gabriele
authors.initials: G
authors.lastname: Greco
authors.forename: Tiziana
authors.initials: T
authors.lastname: Mangieri
authors.forename: Antonio
authors.initials: A
authors.lastname: Pezzarossa
authors.forename: Davide
authors.initials: D
authors.lastname: Dazzi
authors.forename: Haslinda
authors.initials: H
authors.lastname: Hassan
mesh_terms: D000328:Adult; D001323:Autoantibodies / Q000097:blood*; D019587:Dietary Supplements; D005260:Female; D006801:Humans; D007453:Iodide Peroxidase / Q000276:immunology*; D010298:Parity; D010919:Placebos; D049590:Postpartum Period / Q000187:drug effects / Q000502:physiology*; D011247:Pregnancy / Q000097:blood / Q000276:immunology*; D011446:Prospective Studies; D012645:Selenomethionine / Q000008:administration & dosage / Q000627:therapeutic use*; D013960:Thyroid Function Tests; D013972:Thyrotropin / Q000097:blood; D044465:White People
chemical_list: D001323:Autoantibodies; D010919:Placebos; D013972:Thyrotropin; D012645:Selenomethionine; D007453:Iodide Peroxidase