title: [The effect of TNF-alpha & IL-8 in the pathogenesis of allergic rhinitis].
abstract: OBJECTIVE
  To survey the effects of TNF-alpha and IL-8 in the pathogenesis of allergic rhinitis.
  
  
  METHODS
  The serum levels of TNF-alpha and IL-8 in 102 cases of seasonal or non-seasonal allergic rhinitis were detected pre and post specific immunotherapy (SIT), and the results were statistically analyzed.
  
  
  RESULTS
  The levels of TNF-alpha and IL-8 in experiment group were significant higher than that in the health control. And the levels of TNF-alpha and IL-8 significantly decreased post SIT in the experiment group.
  
  
  CONCLUSIONS
  TNF-alpha and IL-8 play important roles in the pathogenesis of allergic rhinitis.
authors.affiliation: Department of Allergy, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China. Wangzhxl@yahoo.com.cn
authors.forename: Zhongxi
authors.initials: Z
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D000328:Adult; D006801:Humans; D016209:Interleukin-8 / Q000097:blood*; D008875:Middle Aged; D012221:Rhinitis, Allergic, Perennial / Q000378:metabolism*; D006255:Rhinitis, Allergic, Seasonal / Q000378:metabolism*; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*; D055815:Young Adult
chemical_list: C508606:CXCL8 protein, human; D016209:Interleukin-8; D014409:Tumor Necrosis Factor-alpha