title: [Delta-opioid receptor activation prevents appearance of irreversible damages of cardiomyocytes and exacerbates myocardial contractility dysfunction during ischemia and reperfusion].
abstract: It is shown that prestimulation of cardiac delta-opioid receptors (OR) by selective agonists (DPDPE and TAN-67) decreases creatine kinase levels in the coronary effluent of isolated rat heart during 45-min global ischemia and 30-min reperfusion. This effect was completely abolished by pretreatment with a delta-antagonist naltrindole or a non-selective agonist naloxone. It was found that preactivation of cardiac delta-OR exacerbates reperfusion contractility dysfunction of the heart. This effect was also eliminated by opioid receptor antagonists. It is suggested that stimulation of cardiac delta-OR prevents irreversible cardiac cell damage but exacerbates contractility dysfunction during ischemia and reperfusion in vitro.
authors.forename: L N
authors.initials: LN
authors.lastname: Maslov
authors.forename: A A
authors.initials: AA
authors.lastname: Platonov
authors.forename: T V
authors.initials: TV
authors.lastname: Lasukova
authors.forename: Iu B
authors.initials: IuB
authors.lastname: Lishmanov
authors.forename: P
authors.initials: P
authors.lastname: Oeltgen
authors.forename: H
authors.initials: H
authors.lastname: Nagase
authors.forename: Iu K
authors.initials: IuK
authors.lastname: Podoksenov
authors.forename: A Iu
authors.initials: AIu
authors.lastname: Podoksenov
mesh_terms: D000818:Animals; D003402:Creatine Kinase / Q000032:analysis; D020881:Enkephalin, D-Penicillamine (2,5)- / Q000494:pharmacology; D006321:Heart / Q000503:physiopathology; D066298:In Vitro Techniques; D008297:Male; D009200:Myocardial Contraction; D015428:Myocardial Reperfusion Injury / Q000378:metabolism / Q000473:pathology* / Q000517:prevention & control*; D032383:Myocytes, Cardiac / Q000473:pathology*; D018377:Neurotransmitter Agents / Q000494:pharmacology; D011804:Quinolines / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D017465:Receptors, Opioid, delta / Q000819:agonists*
chemical_list: D018377:Neurotransmitter Agents; D011804:Quinolines; D017465:Receptors, Opioid, delta; C094142:TAN 67; D020881:Enkephalin, D-Penicillamine (2,5)-; D003402:Creatine Kinase