title: Multiplexed electrochemical protein coding based on quantum dot (QD)-bioconjugates for a clinical barcode system.
abstract: An ultrasensitive imumunodiagnostic readout method based on an electrochemical analysis is presented. Different high-quality quantum dot (QD) nanocrystals (ZnS, CdS, and PbS) are tagged to antibodies for the on-site voltammetric stripping measurements of multiple antigen targets. These encoding QD tracers with distinct redox potential yield highly sensitive and selective stripping peaks at -1.11 V (Zn), -0.67 V (Cd) and - 0.52 V (Pb) at the mercury-coated glassy carbon electrode (vs. Ag/AgCI reference). The position and size of these peaks reflect the identity and level of the corresponding antigen target. The analog peaks of the QDs were converted to a digital bio-barcode system for simple and rapid medical diagnostics.
authors.affiliation: Dept. of Chem. & Biochem., New Mexico State Univ., Las Cruces, NM 88003, USA.
authors.forename: Jeonghwan
authors.initials: J
authors.lastname: Kim
authors.forename: Kyungsik
authors.initials: K
authors.lastname: Seo
authors.forename: Joseph
authors.initials: J
authors.lastname: Wang