title: [Systemic thrombolysis in ischemic stroke].
abstract: Intravenous recombinant tissue plasminogen activator (rt-PA) is an approved and effective treatment for acute ischemic stroke within 3 hours of symptoms onset. The results of the first-ever implementation of the thrombolysis in the Russian Federation are presented. Fourteen stroke patients received rt-PA in dose of 0.9 mg/kg (10% as a bolus during 1 minute followed by infusion), the mean "door-to-needle" time was 50 +/- 23.6 min. The thrombolysis resulted in the clinical improvement by the end of the first day after stroke onset in 9 (64.2%) patients, with a dramatic regress of neurological deficit (the decrease of the NIHSS scores = 4) in 3 (21.4%) of them. Hemorrhagic transformation was observed in 6 (42.8%) patients, however in 5 cases it was asymptomatic and was found only in the repeated CT study to the end of the first day. Three months after stroke onset, 7 (50%) patients scored 0-1 on the modified Rankin scale, 1 patient had 4 scores and 1 patient died. Thus the thrombolysis can change the stroke management and significantly improves the outcome.
authors.forename: V I
authors.initials: VI
authors.lastname: Skvortsova
authors.forename: G N
authors.initials: GN
authors.lastname: Golukhov
authors.forename: L V
authors.initials: LV
authors.lastname: Gubskiĭ
authors.forename: N A
authors.initials: NA
authors.lastname: Shamalov
authors.forename: A M
authors.initials: AM
authors.lastname: Sidorov
authors.forename: M K
authors.initials: MK
authors.lastname: Bodykhov
authors.forename: G R
authors.initials: GR
authors.lastname: Ramazanov
authors.forename: P V
authors.initials: PV
authors.lastname: Iakimovich
authors.forename: A S
authors.initials: AS
authors.lastname: Kireev
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002545:Brain Ischemia / Q000000981:diagnostic imaging / Q000188:drug therapy*; D005260:Female; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D014057:Tomography, X-Ray Computed; D018608:Ultrasonography, Doppler
chemical_list: D005343:Fibrinolytic Agents