title: [Anastomotic configuration as a risk factor in the recurring onset after intestinal resection for Crohn's disease: our point of view].
abstract: Crohn's disease is an inflammatory chronic intestinal disease characterized of an high level of postoperative recurrence. Actually surgical treatment is not decisive; patients can undergo several operations during their lives, running the risk of coming up against the syndrome of short bowel. The main disease frequently appears in the segment ileo-caecal, while the site more often affected by the recurrence seems to be the stump close to the anastomosis. General, local and not specific factors should influence the recurrence level. Among the general factors, cigarette smoking would have a leading role in the recurrences onset. Giving up smoking and a treatment with 5-ASA (amino-salicylic acid) help to reduce the risk of Crohn's recurrences after surgery. During the treatment of this pathology the wide intestinal resections are not justified because the anastomotic recurrence after resection seems to be influenced not by the presence of remaining lesions but by the type of realized anastomosis. Although they disagree about the type of anastomosis to adopt, the authors agree identifying the anastomotic stenosis as the main factor which determines the recurrences. Stenosis, in fact, determining fecal stasis and, therefore, the increase of the pressure at the intestinal wall level, causes ischemia of this same wall. Ischemia puts up the risk of fistulas and anastomotic dehiscence. The mechanical or manual ileo-colic side-to-side anastomosis, assuring a wide lumen, drops to the minimum the risk of stenosis compared with the end-to-end and end-to-side configurations. And then, the side-to-side ileo-colic anastomosis avoiding the intestinal compartmentation between ileo and colon, guarantees less reflow in the small bowel of bacteria and colic metabolite. In this way the inflammatory process which brings to the fresh outbreak of the disease on the mucosa of the near anastomotic head faints. In the light of this thesis, most of the authors, including the writer, agree about making the side-to-side anastomoses in the intestinal resections for the Crohn's disease.
authors.affiliation: VII Divisione di Chirurgia Generale, Facoltà di Medicina e Chirurgia, Seconda Università degli Studi di Napoli, Napoli, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Candela
authors.forename: L
authors.initials: L
authors.lastname: Di Libero
authors.forename: S
authors.initials: S
authors.lastname: Varriale
authors.forename: F
authors.initials: F
authors.lastname: Manetta
authors.forename: M
authors.initials: M
authors.lastname: Giordano
authors.forename: M
authors.initials: M
authors.lastname: Lanza
authors.forename: A
authors.initials: A
authors.lastname: Nunziata
authors.forename: L
authors.initials: L
authors.lastname: Santini
mesh_terms: D000328:Adult; D000714:Anastomosis, Surgical / Q000379:methods; D044684:Colon, Transverse / Q000601:surgery*; D003424:Crohn Disease / Q000601:surgery*; D005260:Female; D006801:Humans; D007082:Ileum / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D012307:Risk Factors