title: Survival after disseminated invasive aspergillosis in a multivisceral transplant recipient.
abstract: Disseminated invasive aspergillosis is a serious and potentially lethal infectious complication of immunosuppressed individuals, including transplant recipients. We report here a successfully treated case of disseminated Aspergillus fumigatus infection involving the lungs, brain, and endocardium in a multivisceral transplant recipient. In addition to supportive measures, the patient was aggressively treated with a combination of three antifungal agents, and all immunosuppression was significantly lowered with close observation for rejection. After 3 months of therapy, the patient cleared the fungal infection, made a full recovery of his cerebral function, and was discharged to a rehabilitation facility.
authors.affiliation: Department of Surgery, Indiana University, Indianapolis, IN 46202, USA. rvianna@iupui.edu
authors.forename: R
authors.initials: R
authors.lastname: Vianna
authors.forename: V
authors.initials: V
authors.lastname: Misra
authors.forename: J A
authors.initials: JA
authors.lastname: Fridell
authors.forename: M
authors.initials: M
authors.lastname: Goldman
authors.forename: R S
authors.initials: RS
authors.lastname: Mangus
authors.forename: J
authors.initials: J
authors.lastname: Tector
mesh_terms: D000328:Adult; D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D001228:Aspergillosis / Q000000981:diagnostic imaging*; D017548:Echocardiography, Transesophageal; D006509:Hepatitis B / Q000601:surgery*; D006801:Humans; D007421:Intestine, Small / Q000637:transplantation*; D016031:Liver Transplantation; D008279:Magnetic Resonance Imaging; D008297:Male; D016035:Pancreas Transplantation; D011183:Postoperative Complications / Q000188:drug therapy / Q000382:microbiology; D013270:Stomach / Q000637:transplantation*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D000935:Antifungal Agents; D000666:Amphotericin B