title: [A case of granulocyte-colony stimulating factor producing ductal adenocarcinoma of the pancreas].
abstract: We report a case of pancreatic ductal adenocarcinoma producing granulocyte-colony stimulating factor (G-CSF). A 56-year-old Japanese man was admitted to our hospital with back pain and high fever. An abdominal CT scan revealed masses in the pancreatic body to the tail, and both lobes of the liver. A biopsy specimen of the hepatic tumor demonstrated metastatic poorly differentiated adenocarcinoma. We administered oral S-1 in combination with gemcitabine. However, his general condition gradually worsened, and a high serum level of G-CSF persisted. He died 135 days after admission. The diagnosis of autopsy was pancreatic ductal adenocarcinoma. Immunohistochemical staining showed the presence of G-CSF in tumor cells. The final diagnosis was G-CSF-producing pancreatic carcinoma.
authors.affiliation: Department of Gastroenterology, Hokkaido University, Graduate School of Medicine.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kawakami
authors.forename: Masaki
authors.initials: M
authors.lastname: Kuwatani
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Fujiya
authors.forename: Minoru
authors.initials: M
authors.lastname: Uebayashi
authors.forename: Kohei
authors.initials: K
authors.lastname: Konishi
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Makiyama
authors.forename: Satoshi
authors.initials: S
authors.lastname: Hashino
authors.forename: Kanako
authors.initials: K
authors.lastname: Kubota
authors.forename: Tomoo
authors.initials: T
authors.lastname: Itoh
authors.forename: Masahiro
authors.initials: M
authors.lastname: Asaka
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism* / Q000473:pathology; D021441:Carcinoma, Pancreatic Ductal / Q000378:metabolism* / Q000473:pathology; D005334:Fever / Q000209:etiology; D016179:Granulocyte Colony-Stimulating Factor / Q000096:biosynthesis* / Q000097:blood; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000378:metabolism* / Q000473:pathology
chemical_list: D015850:Interleukin-6; D016179:Granulocyte Colony-Stimulating Factor