title: Effects of a pneumatic tube system on routine and novel hematology and coagulation parameters in healthy volunteers.
abstract: BACKGROUND
  Technologic advances affecting analyzers used in clinical laboratories have changed the methods used to obtain many laboratory measurements, and many novel parameters are now available. The effects of specimen transport through a pneumatic tube system on laboratory results obtained with such modern instruments are unclear.
  
  
  OBJECTIVE
  To determine the effects of sample transport through a pneumatic tube system on routine and novel hematology and coagulation parameters obtained on state-of-the-art analyzers.
  
  
  METHODS
  Paired blood samples from 33 healthy volunteers were either hand delivered to the clinical laboratory or transported through a pneumatic tube system.
  
  
  RESULTS
  No statistically significant differences were observed for routine complete blood cell count and white cell differential parameters or markers of platelet activation, such as the mean platelet component, or of red cell fragmentation. When 2 donors who reported aspirin intake were excluded from the analysis, there was a statistically, but not clinically, significant impact of transport through the pneumatic tube system on the mean platelet component. There were no statistically significant differences for prothrombin time, activated partial thromboplastin time, waveform slopes for prothrombin time or activated partial thromboplastin time, fibrinogen, or fibrin monomers.
  
  
  CONCLUSIONS
  Although further study regarding the mean platelet component may be required, transport through a pneumatic tube system has no clinically significant effect on hematology and coagulation results obtained with certain modern instruments in blood samples from healthy volunteers.
authors.affiliation: Division of Laboratory Medicine, Department of Pathology, Massachusetts General Hospital, and Harvard Medical School, Boston, USA. ak2651@columbia.edu
authors.forename: Alexander
authors.initials: A
authors.lastname: Kratz
authors.forename: Raneem O
authors.initials: RO
authors.lastname: Salem
authors.forename: Elizabeth M
authors.initials: EM
authors.lastname: Van Cott
mesh_terms: D001777:Blood Coagulation / Q000502:physiology; D001800:Blood Specimen Collection / Q000295:instrumentation*; D005260:Female; D006403:Hematologic Tests / Q000295:instrumentation*; D006405:Hematology / Q000295:instrumentation; D006801:Humans; D048228:Intermittent Pneumatic Compression Devices; D008297:Male