Formulation and characterization of curcuminoids loaded solid lipid nanoparticles.
Curcuminoids loaded solid lipid nanoparticles (SLNs) have been successfully developed using a microemulsion technique at approximately 75 degrees C. It was found that variation in the amount of ingredients had profound effects on the curcuminoid loading capacity, the mean particle size, and size distribution. At optimized process conditions, lyophilized curcuminoids loaded SLNs showed spherical particles with a mean particle size of approximately 450nm and a polydispersity index of 0.4. Up to 70% (w/w) curcuminoids incorporation efficacy was achieved. In vitro release studies showed a prolonged release of the curcuminoids from the solid lipid nanoparticles up to 12h following the Higuchi's square root model. After 6-month storage at room temperature in the absence of sunlight, the physical and chemical stabilities of the lyophilized curcuminoids loaded SLNs could be maintained, i.e. the mean particle size and the amount of curcuminoids showed no significant changes (P>0.05) compared to the freshly prepared SLNs. In addition, the chemical stability of curcuminoids incorporated into SLNs was further investigated by dispersing them into a model cream base. The results revealed that after storage in the absence of sunlight for 6 months, the percentages of the remaining curcumin, bisdemethoxycurcumin and demethoxycurcumin were 91, 96 and 88, respectively.
Tiyaboonchai
Waree
W
Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Naresuan University, Pitsanulok 65000, Thailand. wareet@nu.ac.th
Tungpradit
Watcharaphorn
W
Plianbangchang
Pinyupa
P
D000975:Antioxidants / Q000737:chemistry* / Q000528:radiation effects; D002626:Chemistry, Pharmaceutical; D003474:Curcumin / Q000031:analogs & derivatives* / Q000737:chemistry* / Q000528:radiation effects; D036381:Diarylheptanoids; D004337:Drug Carriers; D004339:Drug Compounding; D004355:Drug Stability; D004356:Drug Storage; D004655:Emulsions; D007700:Kinetics; D008055:Lipids / Q000737:chemistry*; D008956:Models, Chemical; D053758:Nanoparticles; D009824:Ointments; D010084:Oxidation-Reduction; D010100:Oxygen / Q000737:chemistry; D010316:Particle Size; D010782:Photolysis; D012995:Solubility; D013472:Sunlight; D013499:Surface Properties; D013678:Technology, Pharmaceutical / Q000379:methods; D013696:Temperature
D000975:Antioxidants; D036381:Diarylheptanoids; D004337:Drug Carriers; D004655:Emulsions; D008055:Lipids; D009824:Ointments; C034786:bisdemethoxycurcumin; D003474:Curcumin; D010100:Oxygen; C050229:demethoxycurcumin