The influence of n-6 fatty acid supplemented diet on the effect of imipramine in an animal model of depression.
Recent data have shown an association between polyunsaturated fatty acid and depression. This study examined the effect of the supplementation with n-6 fatty acid on the behavior of rats treated with imipramine and submitted to the Forced Swimming Test (FST). Non-supplemented imipramine-treated rats presented a significant reduction of immobility time in the FST whereas n-6 fatty acid-supplemented rats showed a significantly higher immobility time. Imipramine significantly increased norepinephrine plasma concentrations in the two groups. These results show that the diet supplemented with n-6 fatty acid altered the behavior of the animals in the FST, inhibiting the imipramine effect.
Borsonelo
Elizabethe C
EC
Department of Psychobiology, Federal University of São Paulo, São Paulo, Brazil. ellizabethe@psicobio.epm.br
Galduróz
Jose C F
JC
Suchecki
Deborah
D
Calil
Helena M
HM
D000818:Animals; D000929:Antidepressive Agents, Tricyclic / Q000494:pharmacology*; D001835:Body Weight / Q000187:drug effects; D002395:Catecholamines / Q000097:blood; D002851:Chromatography, High Pressure Liquid; D003863:Depression / Q000188:drug therapy* / Q000523:psychology; D004032:Diet; D004563:Electrochemistry; D043371:Fatty Acids, Omega-6 / Q000494:pharmacology*; D007099:Imipramine / Q000494:pharmacology*; D008297:Male; D010938:Plant Oils / Q000737:chemistry; D031825:Primula / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin / Q000097:blood; D013550:Swimming / Q000523:psychology
D000929:Antidepressive Agents, Tricyclic; D002395:Catecholamines; D043371:Fatty Acids, Omega-6; D010938:Plant Oils; D012701:Serotonin; D007099:Imipramine