[The concept of endocrine disruption and human health].
In Europe, endocrine disruptors (EDs) have been defined as substances foreign to the body that have deleterious effects on the individuals or their descendants, due to changes in endocrine function. In the United States, EDs have been described as exogenous agents that interfere with the production, release, transport, metabolism, binding, action or elimination of the natural ligands responsible for maintaining homeostasis and regulating body development. These two definitions are complementary, but both indicate that the effects induced by EDs probably involve mechanisms relating in some way to hormonal homeostasis and action. EDs are generally described as substances with anti-oestrogenic, oestrogenic, anti-androgenic or androgenic effects. More recently, other targets have been evidenced such as the thyroid and immune system. Many different EDs are present in the various compartments of the environment (air, water and land) and in foods (of plant and animal origin). They may originate from food packaging, combustion products, plant health treatments, detergents and the chemical industry in general. In addition to the potential effects of these compounds on adults, the sensitivity of embryos and fetuses to many of the xenobiotic compounds likely to cross the placenta has raised considerable concern and led to major research efforts. With the exception of the clearly established links between diethylstilbestrol, reproductive health abnormalities and cancers, very little is known for certain about the effects of EDs on human health. Given the lack of available data, current concerns about the possible involvement of EDs in the increase in the incidence of breast cancer, and possibly of endometriosis and early puberty in girls, remain hypothetical. Conversely, the deterioration in male reproductive health is at the heart of preoccupations and progress in analyses of the relationship between EDs and human health. This literature review aims to describe the current state of knowledge about endocrine disruption, focusing in particular on the problem of food contaminants.
Cravedi
Jean-Pierre
JP
Inra, UMR 1089, Xénobiotiques, BP 3, 31931 Toulouse Cedex 9, France.
Zalko
Daniel
D
Savouret
Jean-François
JF
Menuet
Arnaud
A
Jégou
Bernard
B
D000014:Abnormalities, Drug-Induced / Q000453:epidemiology / Q000209:etiology; D000818:Animals; D001559:Benzhydryl Compounds; D004054:Diethylstilbestrol / Q000009:adverse effects; D052244:Endocrine Disruptors / Q000009:adverse effects* / Q000494:pharmacology / Q000633:toxicity; D004700:Endocrine System Diseases / Q000139:chemically induced / Q000453:epidemiology; D004782:Environmental Health; D004785:Environmental Pollutants / Q000009:adverse effects; D005260:Female; D005333:Fetus / Q000187:drug effects; D005506:Food Contamination; D006059:Gonadal Dysgenesis / Q000139:chemically induced / Q000453:epidemiology; D006706:Homeostasis / Q000187:drug effects; D006801:Humans; D007220:Industrial Waste / Q000009:adverse effects; D007248:Infertility, Male / Q000139:chemically induced / Q000453:epidemiology; D008297:Male; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced / Q000196:embryology; D009369:Neoplasms / Q000139:chemically induced / Q000453:epidemiology; D010573:Pesticide Residues / Q000009:adverse effects; D010636:Phenols / Q000009:adverse effects; D010795:Phthalic Acids / Q000009:adverse effects; D048789:Phytoestrogens / Q000009:adverse effects / Q000627:therapeutic use / Q000633:toxicity; D010969:Plastics / Q000009:adverse effects; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D000098826:Bisphenol A Compounds
D001559:Benzhydryl Compounds; D004054:Diethylstilbestrol; D052244:Endocrine Disruptors; D004785:Environmental Pollutants; D007220:Industrial Waste; D010573:Pesticide Residues; D010636:Phenols; D010795:Phthalic Acids; D048789:Phytoestrogens; D010969:Plastics; C032279:phthalic acid; C041594:4-nonylphenol; C006780:bisphenol A; D000098826:Bisphenol A Compounds