title: A dosimetric comparison of 169Yb and 192Ir for HDR brachytherapy of the breast, accounting for the effect of finite patient dimensions and tissue inhomogeneities.
abstract: Monte Carlo simulation dosimetry is used to compare 169Yb to 192Ir for breast high dose rate (HDR) brachytherapy applications using multiple catheter implants. Results for bare point sources show that while 169Yb delivers a greater dose rate per unit air kerma strength at the radial distance range of interest to brachytherapy in homogeneous water phantoms, it suffers a greater dose rate deficit in missing scatter conditions relative to 192Ir. As a result of these two opposing factors, in the scatter conditions defined by the presence of the lung and the finite patient dimensions in breast brachytherapy the dose distributions calculated in a patient equivalent mathematical phantom by Monte Carlo simulations for the same implant of either 169Yb or 1921r commercially available sources are found comparable. Dose volume histogram results support that 169Yb could be at least as effective as 192Ir delivering the same dose to the lung and slightly reduced dose to the breast skin. The current treatment planning systems' approach of employing dosimetry data precalculated in a homogeneous water phantom of given shape and dimensions, however, is shown to notably overestimate the delivered dose distribution for 169Yb. Especially at the skin and the lung, the treatment planning system dose overestimation is on the order of 15%-30%. These findings do not undermine the potential of 169Yb HDR sources for breast brachytherapy relative to the most commonly used 192Ir HDR sources. They imply, however, that there could be a need for the amendment of dose calculation algorithms employed in clinical treatment planning of particular brachytherapy applications, especially for intermediate photon energy sources such as 169Yb.
authors.affiliation: Nuclear and Particle Physics Section, Physics Department, University of Athens, Panepistimioupolis, Ilisia, 157 71, Athens, Greece. glymper@phys.uoa.gr
authors.forename: G
authors.initials: G
authors.lastname: Lymperopoulou
authors.forename: P
authors.initials: P
authors.lastname: Papagiannis
authors.forename: A
authors.initials: A
authors.lastname: Angelopoulos
authors.forename: P
authors.initials: P
authors.lastname: Karaiskos
authors.forename: E
authors.initials: E
authors.lastname: Georgiou
authors.forename: D
authors.initials: D
authors.lastname: Baltas
mesh_terms: D000465:Algorithms; D001918:Brachytherapy / Q000379:methods*; D001940:Breast / Q000473:pathology; D001943:Breast Neoplasms / Q000532:radiotherapy*; D002404:Catheterization; D006801:Humans; D007496:Iridium Radioisotopes / Q000627:therapeutic use*; D008962:Models, Theoretical; D009010:Monte Carlo Method; D019047:Phantoms, Imaging; D011868:Radioisotopes / Q000627:therapeutic use*; D011874:Radiometry / Q000379:methods*; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods; D014867:Water / Q000737:chemistry; D015018:Ytterbium / Q000627:therapeutic use*
chemical_list: D007496:Iridium Radioisotopes; D011868:Radioisotopes; D014867:Water; D015018:Ytterbium