title: [Immunohistochemical study on contents of beta-amyloid, alpha-actin and collagen IV in cerebral small vessels with unknown type of pathological lesion].
abstract: OBJECTIVE
  To investigate the structural characteristics of the cerebral small vessels with an unknown type of pathological lesion (UTPL).
  
  
  METHODS
  Contents of beta-amyloid, alpha-actin and collagen IV in cerebral small vessels with UTPL were studied by Congo red staining, immunohistochemical staining and computer image analysis.
  
  
  RESULTS
  The low expression levels of alpha-actin and collagen IV (P<0.05) were observed in tunica media of the vessels with UTPL, and no positive expression of beta-amyloid (P>0.05) was observed in these vessel walls. The expressions of proteins mentioned above in UTPL were different from those of cerebral amyloid angiopathy(CAA) and hyaline arteriolosclerosis.
  
  
  CONCLUSIONS
  UTPL was different from CAA or hyaline arteriolosclerosis in pathologic feature.
authors.affiliation: Department of Forensic Pathology, School of Forensic Medicine, China Medical University, Shenyang 110001, China. zm_123@sina.com
authors.forename: Min
authors.initials: M
authors.lastname: Zhang
authors.forename: Da-wei
authors.initials: DW
authors.lastname: Guan
authors.forename: Rui
authors.initials: R
authors.lastname: Zhao
authors.forename: Geng-yi
authors.initials: GY
authors.lastname: Hu
authors.forename: Yang
authors.initials: Y
authors.lastname: Han
authors.forename: Zhen-huan
authors.initials: ZH
authors.lastname: Hou
authors.forename: Ya-ming
authors.initials: YM
authors.lastname: Shan
mesh_terms: D000199:Actins / Q000378:metabolism*; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D001344:Autopsy; D001808:Blood Vessels / Q000378:metabolism* / Q000473:pathology / Q000648:ultrastructure; D001921:Brain / Q000098:blood supply / Q000378:metabolism / Q000473:pathology*; D016657:Cerebral Amyloid Angiopathy / Q000378:metabolism / Q000473:pathology; D024141:Collagen Type IV / Q000378:metabolism*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007150:Immunohistochemistry; D013194:Staining and Labeling; D013345:Subarachnoid Hemorrhage / Q000378:metabolism* / Q000473:pathology
chemical_list: D000199:Actins; D016229:Amyloid beta-Peptides; D024141:Collagen Type IV