title: Simultaneous occurrence of peripheral T-cell lymphoma unspecified and B-cell small lymphocytic lymphoma. Report of 2 cases.
abstract: We report on 2 composite lymphomas occurring in elderly patients, morphologically characterized by the combination of peripheral T-cell lymphoma (PTCL) unspecified and B-cell small lymphocytic lymphoma. Immunohistochemistry provided objective confirmation of the coexistence of the 2 malignancies, as did molecular biology by revealing clonal T-cell receptor gamma and immunoglobulin heavy chain gene rearrangements. One of the patients had no history of indolent lymphoma either at the personal and family level, whereas the other showed a strong familial predisposition, his mother and sister having suffered from B-cell chronic lymphocytic leukemia. Epstein-Barr virus was detected in the PTCL component of 1 case, but was negative in the other. To the best of our knowledge, the simultaneous occurrence of PTCL unspecified and B-cell small lymphocytic lymphoma is an exceptional event; the possible pathogenetic correlations between the 2 neoplasms are discussed.
authors.affiliation: Institute of Hematology and Clinical Oncology L. and A. Seràgnoli, Unit of Hematopathology, Bologna University School of Medicine, Bologna, Italy. cristina.campidelli@virgilio.it
authors.forename: Cristina
authors.initials: C
authors.lastname: Campidelli
authors.forename: Elena
authors.initials: E
authors.lastname: Sabattini
authors.forename: Milena
authors.initials: M
authors.lastname: Piccioli
authors.forename: Maura
authors.initials: M
authors.lastname: Rossi
authors.forename: Donatella
authors.initials: D
authors.lastname: De Blasi
authors.forename: Eustachio
authors.initials: E
authors.lastname: Miraglia
authors.forename: Delvys
authors.initials: D
authors.lastname: Rodriguez-Abreu
authors.forename: Leda Leoncini
authors.initials: LL
authors.lastname: Franscini
authors.forename: Francesco
authors.initials: F
authors.lastname: Bertoni
authors.forename: Luca
authors.initials: L
authors.lastname: Mazzucchelli
authors.forename: Franco
authors.initials: F
authors.lastname: Cavalli
authors.forename: Emanuele
authors.initials: E
authors.lastname: Zucca
authors.forename: Stefano A
authors.initials: SA
authors.lastname: Pileri
mesh_terms: D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D016130:Immunophenotyping; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000150:complications*; D016393:Lymphoma, B-Cell / Q000150:complications*; D016411:Lymphoma, T-Cell, Peripheral / Q000150:complications*; D008297:Male; D008875:Middle Aged