Design proposal of imaging activities of cultured neural network on a silicon substrate with neural-electronic-optical integrated microsystem.
Multielectrode Arrays have currently been widely used as Neural-Network research tools. In this paper, we propose a novel mixed integrated sensor array microsystem combining cultured biological neurons, silicon integrated circuits and optical components together on a single silicon substrate. Using the light emitting property of GaAs-LED dependent on current passing from the recorded action potentials signals by a Multielectrode-Array in situ, we are able to characterize the neural activities of the cultured neural networks directly with a visible image displayed by a monitoring CCD Camera. Researchers may use various ready image process tools for experimental data analysis to directly observe results.
Bian
Chao
C
Department of Electronic Engineering, Tsinghua University, Beijing, 100084, P.R. China.
Song
Xindong
X
Liu
Zihong
Z
Zhang
Hanyi
H