title: Taurine ameliorates stress-induced degeneration of the urinary bladder.
abstract: We studied the potential effects of taurine, a free radical scavenger, on chronic water avoidance stress (WAS)-induced degeneration of the mucosa of the urinary bladder in experimental rats. Wistar albino rats were exposed to WAS for 2h/day, for 5 days (WAS group). Before exposing them to WAS, taurine (50mg/kg) (WAS+taurine group) was injected intraperitonally into the animals. Samples of urinary bladder were then investigated by light and scanning electron microscopy. Lipid peroxidation and gluthathione levels were also measured in the urinary bladder. In the WAS-only group, inflammatory cell infiltration, increased number of mast cells in the mucosa and ulcerated areas were observed. In the WAS+taurine group, relatively normal urothelial topography with microvilli, moderate inflammatory cell infiltration and decreased numbers of mast cells in the mucosa were observed. The increased lipid peroxidation and decreased glutathione levels in WAS rats were reversed by taurine treatment. We conclude that taurine protects against WAS-induced oxidant urinary bladder injury, and thus may be a possible therapeutic agent against interstitial cystitis, the symptoms of which are aggravated by stress conditions.
authors.affiliation: Department of Anatomy, School of Medicine, Kocaeli University, Kocaeli, Turkey. alize05@yahoo.com
authors.forename: Ali
authors.initials: A
authors.lastname: Zeybek
authors.forename: Beyhan
authors.initials: B
authors.lastname: Sağlam
authors.forename: Esra
authors.initials: E
authors.lastname: Cikler
authors.forename: Sule
authors.initials: S
authors.lastname: Cetinel
authors.forename: Feriha
authors.initials: F
authors.lastname: Ercan
authors.forename: Göksel
authors.initials: G
authors.lastname: Sener
mesh_terms: D000818:Animals; D002452:Cell Count; D018856:Cystitis, Interstitial / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D004195:Disease Models, Animal; D004924:Escape Reaction; D005260:Female; D016166:Free Radical Scavengers / Q000627:therapeutic use*; D005978:Glutathione / Q000378:metabolism; D007274:Injections, Intraperitoneal; D015227:Lipid Peroxidation / Q000187:drug effects; D008315:Malondialdehyde / Q000378:metabolism; D008407:Mast Cells / Q000187:drug effects / Q000473:pathology; D008855:Microscopy, Electron, Scanning; D051381:Rats; D017208:Rats, Wistar; D013315:Stress, Psychological / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D013654:Taurine / Q000627:therapeutic use*; D001743:Urinary Bladder / Q000187:drug effects / Q000378:metabolism / Q000648:ultrastructure; D014867:Water
chemical_list: D016166:Free Radical Scavengers; D014867:Water; D013654:Taurine; D008315:Malondialdehyde; D005978:Glutathione