Lentiviral vectors for gene therapy of heart disease.
Technological advances in genetic engineering developed over the past few years have been applied to the research and treatment of cardiovascular diseases. In many animal models, gene therapy has been shown to be an effective treatment schema. Some of these gene therapy treatments are now being applied in clinical trials. Also, as the science of gene therapy has progressed, alternative vector systems such as lentiviruses have been developed and implemented. Here we focus on the emerging role of lentiviral vectors in the treatment of cardiovascular disease.
Higuchi
Koji
K
Division of Stem Cell and Developmental Biology, Ontario Cancer Institute, University Health Network, Toronto, Ontario, Canada.
Medin
Jeffrey A
JA
D000818:Animals; D002318:Cardiovascular Diseases / Q000628:therapy*; D015316:Genetic Therapy / Q000379:methods / Q000639:trends; D005822:Genetic Vectors; D006801:Humans; D016086:Lentivirus / Q000235:genetics; D033581:Stem Cell Transplantation