Clinical experience of an iontophoresis based glucose measuring system.
Currently finger pricking is the common method of blood glucose measurement in patients with diabetes mellitus. However, diabetes patients have proven to be reluctant to check their glucose profiles regularly because of the discomfort associated with this technique. Recently, a non-invasive and continuous Reverse Iontophoresis based Glucose Monitoring Device (RIGMD) was developed in Korea. The study was conducted during the period November 2003-January 2004 on 19 in-patients. Glucose measurements were performed using RIGMD between 10 a.m. and 4 p.m. Concurrent plasma glucose levels were checked hourly and subsequently compared with RIGMD data. The mean error of RIGMD measurements was -3.45 +/- 52.99 mg/dL with a mean absolute relative error of 20+/-15.16%. Measurements obtained by RIGMD were correlated with plasma glucose levels (correlation coefficient; 0.784 (p<0.05)) and this correlation was independent of time of data collection. However, after excluding confounding variables this correlation coefficient exhibited a tendency to increase. 98.9% of the results were clinically acceptable by Clarke error grid analysis. We concluded that RIGMD does not have the reliability and accuracy required to wholly replace conventional methods. However, further technical advancements that reduce its shortcomings would make this device useful for the management of diabetes.
Rhee
Sang Youl
SY
Department of Endocrinology, College of Medicine, Kyung Hee University, Seoul, Korea.
Chon
Suk
S
Koh
Gwanpyo
G
Paeng
Jeong Ryung
JR
Oh
Seungjoon
S
Woo
Jeong-taek
JT
Kim
Sung Woon
SW
Kim
Jin-Woo
JW
Kim
Young Seol
YS
D000328:Adult; D000368:Aged; D015190:Blood Glucose Self-Monitoring / Q000009:adverse effects / Q000295:instrumentation*; D005260:Female; D006801:Humans; D007478:Iontophoresis; D016014:Linear Models; D008297:Male; D008875:Middle Aged