[Immunohistochemical study on contents of beta-amyloid, alpha-actin and collagen IV in cerebral small vessels with unknown type of pathological lesion].
OBJECTIVE
To investigate the structural characteristics of the cerebral small vessels with an unknown type of pathological lesion (UTPL).


METHODS
Contents of beta-amyloid, alpha-actin and collagen IV in cerebral small vessels with UTPL were studied by Congo red staining, immunohistochemical staining and computer image analysis.


RESULTS
The low expression levels of alpha-actin and collagen IV (P<0.05) were observed in tunica media of the vessels with UTPL, and no positive expression of beta-amyloid (P>0.05) was observed in these vessel walls. The expressions of proteins mentioned above in UTPL were different from those of cerebral amyloid angiopathy(CAA) and hyaline arteriolosclerosis.


CONCLUSIONS
UTPL was different from CAA or hyaline arteriolosclerosis in pathologic feature.
Zhang
Min
M
Department of Forensic Pathology, School of Forensic Medicine, China Medical University, Shenyang 110001, China. zm_123@sina.com
Guan
Da-wei
DW
Zhao
Rui
R
Hu
Geng-yi
GY
Han
Yang
Y
Hou
Zhen-huan
ZH
Shan
Ya-ming
YM
D000199:Actins / Q000378:metabolism*; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D001344:Autopsy; D001808:Blood Vessels / Q000378:metabolism* / Q000473:pathology / Q000648:ultrastructure; D001921:Brain / Q000098:blood supply / Q000378:metabolism / Q000473:pathology*; D016657:Cerebral Amyloid Angiopathy / Q000378:metabolism / Q000473:pathology; D024141:Collagen Type IV / Q000378:metabolism*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007150:Immunohistochemistry; D013194:Staining and Labeling; D013345:Subarachnoid Hemorrhage / Q000378:metabolism* / Q000473:pathology
D000199:Actins; D016229:Amyloid beta-Peptides; D024141:Collagen Type IV