A spectroscopic and molecular modeling study of sinomenine binding to transferrin.
Sinomenine, an herbal ingredient isolated from Sinomenium acutum, is used for the amelioration of arthritis. It has been found that this molecule could bind to human serum transferrin (Tf), the iron (III) transport protein in the blood, by using fluorescence, circular dichroism (CD) spectroscopy, and molecular modeling methods. The results provide possible usage of transferrin to transport sinomenine.
Du
Hongyan
H
Beijing National Laboratory for Molecular Sciences (BNLMS), State Key Laboratory for Structural Chemistry of Unstable and Stable Species, Center for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, China.
Xiang
Junfeng
J
Zhang
Yazhou
Y
Tang
Yalin
Y
D000465:Algorithms; D002942:Circular Dichroism; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008958:Models, Molecular; D009019:Morphinans / Q000378:metabolism*; D011485:Protein Binding; D032841:Sinomenium / Q000737:chemistry*; D013050:Spectrometry, Fluorescence; D014168:Transferrin / Q000378:metabolism*
D009019:Morphinans; D014168:Transferrin; C009271:sinomenine