title: Micro-field evoked potentials recorded from the porcine sub-dural cortical surface utilizing a microelectrode array.
abstract: A sub-dural surface microelectrode array designed to detect micro-field evoked potentials has been developed. The device is comprised of an array of 350-microm square gold contacts, with bidirectional spacing of 150 microm, contained within a polyimide Kapton material. Cytotoxicity testing suggests that the device is suitable for use with animal and human patients. Implementation of the device in animal studies revealed that reliable evoked potentials could be acquired. Further work will be needed to determine how these micro-field potentials, which demonstrate selectivity for one eye, relate to the distribution of the ocular dominance columns of the occipital cortex.
authors.affiliation: Department of Neurology, The Ohio State University, Means Hall 469, 1654 Upham Drive, Columbus, OH 43210, USA.
authors.forename: Joseph P
authors.initials: JP
authors.lastname: Kitzmiller
authors.forename: Derek J
authors.initials: DJ
authors.lastname: Hansford
authors.forename: Linda D
authors.initials: LD
authors.lastname: Fortin
authors.forename: Karl H
authors.initials: KH
authors.lastname: Obrietan
authors.forename: Valerie K
authors.initials: VK
authors.lastname: Bergdall
authors.forename: David Q
authors.initials: DQ
authors.lastname: Beversdorf
mesh_terms: D000818:Animals; D002470:Cell Survival; D002540:Cerebral Cortex / Q000502:physiology* / Q000648:ultrastructure; D004292:Dominance, Cerebral; D005071:Evoked Potentials / Q000502:physiology*; D006801:Humans; D008839:Microelectrodes; D008855:Microscopy, Electron, Scanning; D009778:Occipital Lobe / Q000502:physiology; D012680:Sensitivity and Specificity; D013552:Swine