title: Cardiovascular changes after pulmonary embolism from injecting calcium phosphate cement.
abstract: Concerns have been raised that the use of calcium phosphate (CaP) cements for the augmentation of fractured, osteoporotic bones may aggravate cardiovascular deterioration in the event of pulmonary cement embolism by stimulating coagulation. The aim of the present study was therefore to investigate the cardiovascular changes after pulmonary embolism of CaP cement using an animal model. In 14 sheep, 2.0 mL CaP or polymethylmethacrylate cement were injected intravenously. Cardiovascular parameters and antithrombin levels were monitored until 60 min postinjection. Postmortem, lungs were subjected to CT scanning, and 3D reconstruction of the cement was performed. Intravenous injection of CaP cement resulted in a more severe increase in pulmonary arterial pressure and decrease in arterial blood pressure. Disintegration of the CaP cement seemed to be the reason for the more severe reaction. There was no evidence of thromboembolism. Disintegration of CaP cement in circulating blood does not only compromise the mechanical properties, but also represents a risk of cardiovascular complications. Reliable cohesion of CaP cements in an aqueous environment is essential for clinical applications such as osteoporotic bone augmentation.
authors.affiliation: MEM Research Center, Institute for Surgical Technology and Biomechanics, Medical Faculty, University of Bern, Switzerland. jorg.krebs@MEMcenter.unibe.ch
authors.forename: Jörg
authors.initials: J
authors.lastname: Krebs
authors.forename: Nikolaus
authors.initials: N
authors.lastname: Aebli
authors.forename: Ben G
authors.initials: BG
authors.lastname: Goss
authors.forename: Sadahiro
authors.initials: S
authors.lastname: Sugiyama
authors.forename: Thibaut
authors.initials: T
authors.lastname: Bardyn
authors.forename: Ilka
authors.initials: I
authors.lastname: Boecken
authors.forename: Patrick J
authors.initials: PJ
authors.lastname: Leamy
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Ferguson
mesh_terms: D000818:Animals; D000991:Antithrombins / Q000032:analysis; D001784:Blood Gas Analysis; D001794:Blood Pressure / Q000187:drug effects; D001843:Bone Cements / Q000633:toxicity*; D002130:Calcium Phosphates / Q000008:administration & dosage / Q000633:toxicity*; D002319:Cardiovascular System / Q000187:drug effects / Q000503:physiopathology; D006976:Hypertension, Pulmonary / Q000139:chemically induced* / Q000175:diagnosis; D007275:Injections, Intravenous; D008168:Lung / Q000000981:diagnostic imaging; D019904:Polymethyl Methacrylate / Q000008:administration & dosage / Q000633:toxicity; D011652:Pulmonary Circulation / Q000187:drug effects; D011655:Pulmonary Embolism / Q000139:chemically induced* / Q000150:complications / Q000000981:diagnostic imaging; D011859:Radiography; D034561:Sheep, Domestic
chemical_list: D000991:Antithrombins; D001843:Bone Cements; D002130:Calcium Phosphates; D019904:Polymethyl Methacrylate; C020243:calcium phosphate