Simultaneous occurrence of peripheral T-cell lymphoma unspecified and B-cell small lymphocytic lymphoma. Report of 2 cases.
We report on 2 composite lymphomas occurring in elderly patients, morphologically characterized by the combination of peripheral T-cell lymphoma (PTCL) unspecified and B-cell small lymphocytic lymphoma. Immunohistochemistry provided objective confirmation of the coexistence of the 2 malignancies, as did molecular biology by revealing clonal T-cell receptor gamma and immunoglobulin heavy chain gene rearrangements. One of the patients had no history of indolent lymphoma either at the personal and family level, whereas the other showed a strong familial predisposition, his mother and sister having suffered from B-cell chronic lymphocytic leukemia. Epstein-Barr virus was detected in the PTCL component of 1 case, but was negative in the other. To the best of our knowledge, the simultaneous occurrence of PTCL unspecified and B-cell small lymphocytic lymphoma is an exceptional event; the possible pathogenetic correlations between the 2 neoplasms are discussed.
Campidelli
Cristina
C
Institute of Hematology and Clinical Oncology L. and A. Seràgnoli, Unit of Hematopathology, Bologna University School of Medicine, Bologna, Italy. cristina.campidelli@virgilio.it
Sabattini
Elena
E
Piccioli
Milena
M
Rossi
Maura
M
De Blasi
Donatella
D
Miraglia
Eustachio
E
Rodriguez-Abreu
Delvys
D
Franscini
Leda Leoncini
LL
Bertoni
Francesco
F
Mazzucchelli
Luca
L
Cavalli
Franco
F
Zucca
Emanuele
E
Pileri
Stefano A
SA
D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D016130:Immunophenotyping; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000150:complications*; D016393:Lymphoma, B-Cell / Q000150:complications*; D016411:Lymphoma, T-Cell, Peripheral / Q000150:complications*; D008297:Male; D008875:Middle Aged