[Research on the association between different levels of serum iron and essential hypertension].
OBJECTIVE
To study the relationship between serum iron(SI) and essential hypertension (EHT) based on population-based samples.


METHODS
Using clustering multistage sampling method, all the people above 18 years old in the target population were investigated. Blood pressure was measured and the questionnaire was used to find out related factors. Five milliliters fast vein blood were drawn and the serum were used for testing on serum iron (SI) and other elements such as blood sugar, cholesterol (CHOL), triglyceride (TG), high density lipoprotein(HDL-C), low density lipoprotein (LDL-C), serum sodium, serum potassium, serum calcium etc. A case control study was carried out with EHT patients from the selected population as case group, and the other healthy peoples as controls. Database was created by Fox Pro and SPSS 10.0 was used for statistical analysis.


RESULTS
The concentrations of SI, with (17.75 +/- 7.66) micromol/ L in EHT group and (17.23 +/- 7.83) micromol/L in control group, showed statistical difference (P < 0.05) between the two groups. The concentrations of SI also showed statistical difference (P < 0.05) between the high DBP and normal group with the average level as (17.84 +/- 7.58) micromol/L in high DBP group and (17.26 +/- 7.85) micromol/L in normal group. Data from monovariate analysis showed that the increase of SI was a risk factor for EHT, DBP and SBP. By multivariate analysis for EHT, while SI still existed in the model (OR = 1.296, 95% CI: 1.057-1.590), but for SBP the results almost remained the same (OR = 1.285, 95% CI:1.102-1.498).


CONCLUSIONS
Data from the results showed that SI was probably a risk factor for EHT.
Shi
Jing-Pu
JP
Department of Clinical Epidemiology, First Affiliated Hospital, China Medical University, Shenyang 110001, China.
Huang
Bei-Ting
BT
Wang
Hai-Long
HL
Jia
Zhi-Mei
ZM
Fu
Ling-Yu
LY
Li
Hui
H
Dong
Wei
W
Dong
Ya-Luo
YL
Zhou
Bo
B
Jiang
Yu-Shan
YS
Wang
Wen-Li
WL
Li
Ji-Guang
JG
D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000453:epidemiology; D007501:Iron / Q000097:blood*; D012307:Risk Factors
D007501:Iron