title: The natural course of non-functioning pituitary macroadenomas.
abstract: OBJECTIVE
  The natural history of non-functioning pituitary macroadenomas (NFMA) has not been completely elucidated. Therefore, we evaluated pituitary function, visual fields, and tumor size during long-term follow-up of non-operated patients with NFMA.
  
  
  METHODS
  Follow-up study.
  
  
  METHODS
  Twenty-eight patients (age 55 +/- 3 years) with NFMA, not operated after initial diagnosis, were included.
  
  
  RESULTS
  Initial presentation was pituitary insufficiency in 44%, visual field defects in 14%, apoplexy in 14%, and chronic headache in 7% of the patients. The duration of follow-up was 85 +/- 13 months. Radiological evidence of tumor growth was observed in 14 out of 28 patients (50%) after duration of follow-up of 118 +/- 24 months. Six patients (21%) were operated, because tumor growth was accompanied by visual field defects. Visual impairments improved in all the cases after transsphenoidal surgery. Spontaneous reduction in tumor volume was observed in eight patients (29%). No independent predictors for increase or decrease in tumor volume could be found by regression analysis.
  
  
  CONCLUSIONS
  Observation alone is a safe alternative for transsphenoidal surgery in selected NFMA patients, without the risk of irreversibly compromising visual function.
authors.affiliation: Department of Endocrinology, Leiden University Medical Center, The Netherlands. o.m.dekkers@lumc.nl
authors.forename: O M
authors.initials: OM
authors.lastname: Dekkers
authors.forename: S
authors.initials: S
authors.lastname: Hammer
authors.forename: R J W
authors.initials: RJ
authors.lastname: de Keizer
authors.forename: F
authors.initials: F
authors.lastname: Roelfsema
authors.forename: P J
authors.initials: PJ
authors.lastname: Schutte
authors.forename: J W A
authors.initials: JW
authors.lastname: Smit
authors.forename: J A
authors.initials: JA
authors.lastname: Romijn
authors.forename: A M
authors.initials: AM
authors.lastname: Pereira
mesh_terms: D000236:Adenoma / Q000453:epidemiology* / Q000473:pathology* / Q000601:surgery; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006261:Headache / Q000453:epidemiology / Q000601:surgery; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010899:Pituitary Apoplexy / Q000453:epidemiology / Q000601:surgery; D010907:Pituitary Hormones / Q000172:deficiency; D010911:Pituitary Neoplasms / Q000453:epidemiology* / Q000473:pathology* / Q000601:surgery; D012307:Risk Factors; D016896:Treatment Outcome; D014786:Vision Disorders / Q000453:epidemiology / Q000601:surgery; D014794:Visual Fields
chemical_list: D010907:Pituitary Hormones