title: Why is evidence-based medicine so harsh on vaccines? An exploration of the method and its natural biases.
abstract: Vaccines have been hailed as one of the greatest success stories of public health in the 20th century. The 20th century also produced a call for evidence-based medicine (EBM) with applications inclusive of preventive health. Since then, several major EBM analyses have called into question vaccine practices well-accepted by physicians, public health officials, and even the lay public. For example, while counter to existing studies and policies, EBM analyses have concluded that data are lacking to support influenza vaccination of healthcare workers to prevent flu complications among the elderly. In this review, we examine the criticisms and consider the shortcomings in the field of vaccinology as well as in the methodology of evidence-based medicine.
authors.affiliation: Vaccine Research Group, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905-0001, United States. jacobson.robert@mayo.edu
authors.forename: Robert M
authors.initials: RM
authors.lastname: Jacobson
authors.forename: Paul V
authors.initials: PV
authors.lastname: Targonski
authors.forename: Gregory A
authors.initials: GA
authors.lastname: Poland
mesh_terms: D017277:Drug Approval; D004345:Drug Industry; D019317:Evidence-Based Medicine; D006801:Humans; D014612:Vaccines / Q000008:administration & dosage / Q000494:pharmacology / Q000592:standards* / Q000627:therapeutic use*
chemical_list: D014612:Vaccines