[The effect of TNF-alpha & IL-8 in the pathogenesis of allergic rhinitis].
OBJECTIVE
To survey the effects of TNF-alpha and IL-8 in the pathogenesis of allergic rhinitis.


METHODS
The serum levels of TNF-alpha and IL-8 in 102 cases of seasonal or non-seasonal allergic rhinitis were detected pre and post specific immunotherapy (SIT), and the results were statistically analyzed.


RESULTS
The levels of TNF-alpha and IL-8 in experiment group were significant higher than that in the health control. And the levels of TNF-alpha and IL-8 significantly decreased post SIT in the experiment group.


CONCLUSIONS
TNF-alpha and IL-8 play important roles in the pathogenesis of allergic rhinitis.
Wang
Zhongxi
Z
Department of Allergy, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China. Wangzhxl@yahoo.com.cn
D000293:Adolescent; D000328:Adult; D006801:Humans; D016209:Interleukin-8 / Q000097:blood*; D008875:Middle Aged; D012221:Rhinitis, Allergic, Perennial / Q000378:metabolism*; D006255:Rhinitis, Allergic, Seasonal / Q000378:metabolism*; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*; D055815:Young Adult
C508606:CXCL8 protein, human; D016209:Interleukin-8; D014409:Tumor Necrosis Factor-alpha