title: "Threading" of beta-sheet peptides via radical polymerization.
abstract: A nonamer peptide containing a diene group in the center of the sequence was synthesized. When the peptide forms an antiparallel beta-sheet, the diene groups align ca. 5 A apart on the beta-sheet. The diene groups successfully photopolymerized without distorting the beta-sheet structure. The obtained beta-sheet showed high stability against acid denaturation and addition of 1,1,1,3,3,3-hexafluoroisopropanol.
authors.affiliation: Department of Applied Chemistry and Center for Future Chemistry, Kyushu University, 744 Motooka Nishi-ku, Fukuoka 819-0395, Japan. moritcm@mbox.nc.kyushu-u.ac.jp
authors.forename: Takeshi
authors.initials: T
authors.lastname: Mori
authors.forename: Shiro
authors.initials: S
authors.lastname: Yasutake
authors.forename: Hideki
authors.initials: H
authors.lastname: Inoue
authors.forename: Keiji
authors.initials: K
authors.lastname: Minagawa
authors.forename: Masami
authors.initials: M
authors.lastname: Tanaka
authors.forename: Takuro
authors.initials: T
authors.lastname: Niidome
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Katayama
mesh_terms: D000466:Alkadienes; D010455:Peptides / Q000737:chemistry*; D010777:Photochemistry; D020005:Propanols; D011489:Protein Denaturation; D017433:Protein Structure, Secondary; D006845:Hydrocarbons, Fluorinated
chemical_list: D000466:Alkadienes; D010455:Peptides; D020005:Propanols; C001337:hexafluoroisopropanol; D006845:Hydrocarbons, Fluorinated