title: The effect of platelet-rich plasma on bone healing around implants placed in bone defects treated with Bio-Oss: a pilot study in the dog tibia.
abstract: OBJECTIVE
  The aim of this study was to examine the influence of platelet-rich plasma (PRP) used as an adjunct to Bio-Oss for the repair of bone defects adjacent to titanium dental implants.
  
  
  METHODS
  In 6 mongrel dogs, 12 screw-shaped titanium dental implants were inserted into the osteotomy sites in the dogs' tibias. Before implantation, a standardized gap (2.0 mm) was created between the implant surface and the surrounding bony walls. The gaps were filled with either Bio-Oss cancellous granules alone or Bio-Oss cancellous granules mixed with PRP.
  
  
  RESULTS
  After 4 months, the Bio-Oss-treated defects revealed a significantly higher percentage of bone-implant contact than the defects treated with Bio-Oss and PRP (60.1% vs. 30.8%; P < .05).
  
  
  CONCLUSIONS
  The results indicate that when PRP is used as an adjunct to Bio-Oss in the repair of bone defects adjacent to titanium dental implants, PRP may decrease periimplant bone healing.
authors.affiliation: Department of Oral & Maxillofacial Surgery, College of Dentistry, Yonsei University, Seoul, South Korea.
authors.forename: Tae-Min
authors.initials: TM
authors.lastname: You
authors.forename: Byung-Ho
authors.initials: BH
authors.lastname: Choi
authors.forename: Jingxu
authors.initials: J
authors.lastname: Li
authors.forename: Jae-Hyung
authors.initials: JH
authors.lastname: Jung
authors.forename: Hyeon-Jung
authors.initials: HJ
authors.lastname: Lee
authors.forename: Seoung-Ho
authors.initials: SH
authors.lastname: Lee
authors.forename: Seung-Mi
authors.initials: SM
authors.lastname: Jeong
mesh_terms: D000818:Animals; D018786:Bone Substitutes / Q000627:therapeutic use*; D015921:Dental Implants; D004285:Dogs; D005260:Female; D007091:Image Processing, Computer-Assisted; D008903:Minerals / Q000627:therapeutic use*; D010865:Pilot Projects; D053657:Platelet-Rich Plasma / Q000502:physiology*; D013977:Tibia / Q000601:surgery*; D014025:Titanium; D016896:Treatment Outcome; D014945:Wound Healing / Q000502:physiology*
chemical_list: C077540:Bio-Oss; D018786:Bone Substitutes; D015921:Dental Implants; D008903:Minerals; D014025:Titanium