title: Protection of force incentive on bone lose of tail-suspended rats.
abstract: It has been documented that astronauts suffer from a progressive and continuous negative calcium balance in space flight. The aim of this trial was to demonstrate the role of force incentive on protection of bone lose in stimulated microgravity rats.
  
  
  METHODS
  7-week-old male Wistar rats were randomly divided into 3 groups. One group was suspended by tail for 21 days, one groups were suspended for 21 days and play 1 minutes/day of force incentive (2N, 10 Hz), one group served as control. bone mass, biomechanical properties, histomorphometry and biochemical marked were determined. Results Short-time force incentive not only can improve the metabolism of calcium and phosphorus as well as histomorphometry of tibia, but also can increase bone mineral, biomechanical properties and decrease the content of NO in femur. Conclusion Short-time force incentive can protect the bone lose in stimulated microgravity. Compare with the traditional methods such as using drug, the physical methods, for example, short-time force incentive are less vehement and more safety, which can maintain the normal structure of bone. So short-time force incentive maybe can develop to the primary protective method on osteoporosis.
authors.affiliation: Institute of Space Medico-Engineering, Beijing, 100094.
authors.forename: Wan
authors.initials: W
authors.lastname: Yumin
authors.forename: Li
authors.initials: L
authors.lastname: Yinhui
authors.forename: Ma
authors.initials: M
authors.lastname: Yongjie
authors.forename: Zhang
authors.initials: Z
authors.lastname: Xiaoyou
authors.forename: Wang
authors.initials: W
authors.lastname: Honghui
authors.forename: Liu
authors.initials: L
authors.lastname: Yue