A radical role for p38 MAPK in tumor initiation.
It is established that p38 MAPK can negatively regulate tumorigenesis, but the mechanism is incompletely understood. A new study in this issue of Cancer Cell shows that p38 MAP kinase plays a selective role in tumor initiation mediated by oxidative stress.
Kennedy
Norman J
NJ
Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.
Cellurale
Cristina
C
Davis
Roger J
RJ
D000818:Animals; D017209:Apoptosis; D002471:Cell Transformation, Neoplastic; D006801:Humans; D048308:Mitogen-Activated Protein Kinase 14 / Q000235:genetics / Q000502:physiology*; D009369:Neoplasms / Q000201:enzymology* / Q000473:pathology; D018384:Oxidative Stress; D017382:Reactive Oxygen Species / Q000378:metabolism; D015398:Signal Transduction
D017382:Reactive Oxygen Species; D048308:Mitogen-Activated Protein Kinase 14