title: Impact of gender on neointimal hyperplasia following coronary artery stenting.
abstract: Whether gender affects long-term outcomes after bare metal stent implantation remains controversial. The aim of this study was to examine the impact of gender on neointimal hyperplasia in a large cohort of patients after stent implantation using 3-dimensional intravascular ultrasound. Lumen and stent areas were manually traced at 0.5-mm intervals throughout the stented segment. Using Simpson's method, lumen, stent, and neointimal (stent - lumen) volumes were calculated and standardized by stent length. Women were older, presented more often with hyperlipidemia or hypertension, and had smaller reference vessel diameter and mean stent area, compared with men. Although neointimal hyperplasia and neointimal thickness in women were similar to that in men, the percentage of neointimal hyperplasia (neointimal area divided by stent area) was higher in women due to the smaller stent area. After adjusting for stent area, the percentage of neointimal hyperplasia did not differ by gender. In conclusion, the results of this study indicate that neointimal hyperplasia after bare metal stent implantation in women is similar to that seen in men. Despite the similarity in outcome, there are several gender-specific differences in baseline characteristics.
authors.affiliation: Center for Research in Cardiovascular Interventions, Stanford University, Stanford, California, USA.
authors.forename: Hideaki
authors.initials: H
authors.lastname: Kaneda
authors.forename: Junya
authors.initials: J
authors.lastname: Ako
authors.forename: Toru
authors.initials: T
authors.lastname: Kataoka
authors.forename: Takefumi
authors.initials: T
authors.lastname: Takahashi
authors.forename: Mitsuyasu
authors.initials: M
authors.lastname: Terashima
authors.forename: Katsuhisa
authors.initials: K
authors.lastname: Waseda
authors.forename: Akiyoshi
authors.initials: A
authors.lastname: Miyazawa
authors.forename: Ali H M
authors.initials: AH
authors.lastname: Hassan
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Honda
authors.forename: Paul G
authors.initials: PG
authors.lastname: Yock
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Fitzgerald
mesh_terms: D023903:Coronary Restenosis / Q000000981:diagnostic imaging / Q000473:pathology*; D005260:Female; D006801:Humans; D006965:Hyperplasia; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012737:Sex Factors; D015607:Stents; D016896:Treatment Outcome; D017539:Tunica Intima / Q000000981:diagnostic imaging / Q000473:pathology*; D018084:Ultrasonography, Interventional