title: Panhypopituitarism as first manifestation of a lung cancer.
abstract: Pituitary metastases of solid tumours are infrequent, specially as a first manifestation. When they happen, they are usually due to breast or lung cancer and are asymptomatic or produce diabetes insipidus. It is very strange that they produce hormonal deficiency. We present a case report of a bronchogenic adenocarcinoma in a 65-year-old man which began with panhypopituitarism, diabetes insipidus and visual alterations. Magnetic resonance imaging revealed a large sellar mass, with clivus infiltration and invading the right cavernous sinus. The biopsy result was adenocarcinoma metastases from lung cancer.
authors.affiliation: Servicio de Oncología Médica, Hospital General Universitario de Elche, Alicante, Spain. carmenguillenponce@yahoo.es
authors.forename: Carmen
authors.initials: C
authors.lastname: Guillén Ponce
authors.forename: María Pilar
authors.initials: MP
authors.lastname: Garrido López
authors.forename: María José
authors.initials: MJ
authors.lastname: Molina Garrido
authors.forename: Gema
authors.initials: G
authors.lastname: Muñoz Molina
authors.forename: Alfredo
authors.initials: A
authors.lastname: Carrato
mesh_terms: D000230:Adenocarcinoma / Q000150:complications* / Q000556:secondary*; D000368:Aged; D006801:Humans; D007018:Hypopituitarism / Q000209:etiology*; D008175:Lung Neoplasms / Q000473:pathology*; D008297:Male; D010911:Pituitary Neoplasms / Q000150:complications* / Q000556:secondary*