Simulation analysis of nerve block by high frequency biphasic electrical current based on frankenhaeuser-huxley model.
Nerve conduction block induced by high frequency biphasic electrical current was simulated using a lumped circuit model of the myelinated axon based on Frankenhaueuser-Huxley (FH) equations. Axons of different diameters (5-20 &#956;m) can be blocked completed when the stimulation frequency is above 10 kHz. At higher frequency a higher stimulation intensity is needed to block nerve conduction. Larger diameter axons have lower block threshold. The activation of potassium channels, rather than inactivation of sodium channels, is the possible mechanism underlying the nerve conduction block of the myelinated axon induced by high frequency biphasic pulse current. This simulation study, which provides more information about the axonal conduction block induced by high frequency biphasic pulse current, can guide future animal experiments as well as optimize stimulation waveforms for electrical nerve block in possible clinical applications.
Zhang
Xu
X
Capital University of Medical Sciences, Beijing 100054, P.R.China; Department of Pharmacology, University of Pittsburgh, Pittsburgh, PA 15261,USA; E-mail: zh_xu2002@yahoo.com.cn.
Roppolo
James
J
de Groat
William
W
Tai
Changfeng
C