[The extrahypothalamic level of the hypophyseal-adrenocortical system regulation appears to be involved in development of different types of depression-like state in rats].
Possible role of extrahypothalamic corticotrophin-releasing hormone (CRH) and vasopressin-producing centers in post-stress depression development were studied. We used genetically selected strains: KHA (Koltushi High Avoidance) and KLA (Koltushi Low Avoidance) rats developing different types of depression in the "learned helplessness" paradigm: the model analogues of endogenous (KHA strain) and exogenous (KLA strain) depression. Interstrain differences of control and stress-induced CRH- and vasopressin-expression in hippocampus and neocortex in the course of depression development in KHA and KLA rats were revealed using immuno-histochemical studies. It has been shown that a significant increase of CRH- and vasopressin-immune reactivity in hippocampus and neocortex of KHA rats occurred on the 10th post-stress day. We detected also decreased CRH- and vasopressin-expression in dorsal hippocampus, and increased CRH-immune reactivity in neocortex of KLA rats in the same post-stress period. These findings imply that extrahypothalamic CRH- and vasopressin-ergic systems appear to be involved in pathogenesis mechanisms of model analogues of endogenous and exogenous depression in different ways.
Mironova
V I
VI
Rybnikova
E A
EA
D000818:Animals; D003346:Corticotropin-Releasing Hormone / Q000378:metabolism*; D003863:Depression / Q000209:etiology / Q000503:physiopathology* / Q000523:psychology; D006380:Helplessness, Learned; D006624:Hippocampus / Q000378:metabolism; D008297:Male; D019579:Neocortex / Q000378:metabolism; D010913:Pituitary-Adrenal System / Q000503:physiopathology*; D051381:Rats; D011919:Rats, Inbred Strains; D013045:Species Specificity; D013313:Stress Disorders, Post-Traumatic / Q000209:etiology / Q000503:physiopathology; D013315:Stress, Psychological / Q000150:complications / Q000503:physiopathology*; D014667:Vasopressins / Q000378:metabolism*
D014667:Vasopressins; D003346:Corticotropin-Releasing Hormone