title: Glucocorticoids as an adjuvant treatment to intravenous antibiotics for cystic fibrosis pulmonary exacerbations: a UK Survey.
abstract: Oral glucocorticoids are widely used to treat exacerbations of asthma and COPD. A role for their use in treating exacerbations in Cystic Fibrosis (CF) is not proven. We describe the current practice, amongst UK adult CF physicians, of oral glucocorticoid use as an adjuvant to intravenous (IV) antibiotic treatment during CF pulmonary exacerbation (P EX). The survey also examined whether physicians thought a randomised controlled trial (RCT) was necessary and their willingness to participate patients in such a trial. Eighty one percent of physicians replied. All of them used corticosteroids with P EX. Most physicians supported the need for a RCT and would be willing to enroll consenting patients in the trial. This survey highlighted the need for a RCT which would examine the role of adjuvant corticosteroids to IV antibiotics in CF P EX.
authors.affiliation: Adult CF Centre, Bristol Royal Infirmary, Bristol BS2 8HW, United Kingdom.
authors.forename: K L M
authors.initials: KL
authors.lastname: Hester
authors.forename: T
authors.initials: T
authors.lastname: Powell
authors.forename: D G
authors.initials: DG
authors.lastname: Downey
authors.forename: J S
authors.initials: JS
authors.lastname: Elborn
authors.forename: N A
authors.initials: NA
authors.lastname: Jarad
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D003550:Cystic Fibrosis / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D005500:Follow-Up Studies; D005938:Glucocorticoids / Q000008:administration & dosage* / Q000627:therapeutic use; D006801:Humans; D007275:Injections, Intravenous; D011379:Prognosis; D011446:Prospective Studies; D016032:Randomized Controlled Trials as Topic; D012008:Recurrence; D006113:United Kingdom
chemical_list: D000900:Anti-Bacterial Agents; D005938:Glucocorticoids