The factor V Leiden, prothrombin gene 20210GA, methylenetetrahydrofolate reductase 677CT and platelet glycoprotein IIIa 1565TC mutations in patients with acute ischemic stroke and atrial fibrillation.
OBJECTIVE
We wanted to investigate whether common prothrombotic mutations are more prevalent in patients with atrial fibrillation who have had a stroke than in healthy controls. We also wanted to assess whether early recurrent ischemic cerebrovascular events were more frequent among carriers of the factor V Leiden or the prothrombin gene mutations than among others.


METHODS
We used a case-control design with 367 patients with acute ischemic stroke and atrial fibrillation (cases) and 482 healthy blood donors (controls). All mutations were detected with conventional polymerase-chain reaction protocols.


RESULTS
The odds ratios for carriers of the factor V Leiden, prothrombin gene 20210GA, methylenetetrahydrofolate reductase 677CT, or platelet glycoprotein IIIa 1565TC (Pl(A2)) mutation were 0.91, (95% CI, 0.51 to 1.59), 2.25 (95% CI, 0.61 to 8.90), 0.83 (0.61 to 1.13), and 0.79 (0.57 to 1.10), respectively. Early recurrent ischemic stroke and total recurrent ischemic cerebrovascular events were slightly more frequent among carriers of the factor V Leiden mutation than among noncarriers: odds ratio 1.45 (95% CI, 0.41 to 5.1), and 1.59 (0.61 to 4.1), respectively. None of the patients with recurrent ischemic cerebrovascular events had the prothrombin gene mutation.


CONCLUSIONS
These mutations are not important risk factors for thromboembolic stroke associated with atrial fibrillation. Carriers of the factor V Leiden mutation had a small, nonsignificantly higher risk of early recurrent ischemic cerebrovascular events.
Berge
Eivind
E
Haematological Research Laboratory, Department of Clinical Chemistry, Ullevaal University Hospital, Oslo, Norway. eivind.berge@medisin.uio.no
Haug
Kari Bente Foss
KB
Sandset
Else Charlotte
EC
Haugbro
Kaia Kristine
KK
Turkovic
Meliha
M
Sandset
Per Morten
PM
D001281:Atrial Fibrillation / Q000097:blood / Q000201:enzymology / Q000235:genetics*; D002545:Brain Ischemia / Q000097:blood / Q000201:enzymology / Q000235:genetics; D016022:Case-Control Studies; D005165:Factor V / Q000235:genetics*; D006801:Humans; D039661:Integrin beta3 / Q000235:genetics*; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D017354:Point Mutation; D011516:Prothrombin / Q000235:genetics*; D012008:Recurrence; D020521:Stroke / Q000097:blood / Q000201:enzymology / Q000235:genetics*
D039661:Integrin beta3; C095381:factor V Leiden; D005165:Factor V; D011516:Prothrombin; D042965:Methylenetetrahydrofolate Reductase (NADPH2)