title: Crosstalk between Aurora-A and p53: frequent deletion or downregulation of Aurora-A in tumors from p53 null mice.
abstract: The Aurora-A kinase gene is amplified in a subset of human tumors and in radiation-induced lymphomas from p53 heterozygous mice. Normal tissues from p53-/- mice have increased Aurora-A protein levels, but lymphomas from these mice exhibit heterozygous deletions of Aurora-A and/or reduced protein expression. A similar correlation between low p53 levels and Aurora-A gene deletions and expression is found in human breast cancer cell lines. In vitro studies using mouse embryo fibroblasts demonstrate that inhibition of Aurora-A can have either positive or negative effects on cell growth as a function of p53 status. These data have implications for the design of approaches to targeted cancer therapy involving the crosstalk between Aurora-A kinase and p53 pathways.
authors.affiliation: Cancer Research Institute, University of California, San Francisco, San Francisco, CA 94143, USA.
authors.forename: Jian-Hua
authors.initials: JH
authors.lastname: Mao
authors.forename: Di
authors.initials: D
authors.lastname: Wu
authors.forename: Jesus
authors.initials: J
authors.lastname: Perez-Losada
authors.forename: Tao
authors.initials: T
authors.lastname: Jiang
authors.forename: Qian
authors.initials: Q
authors.lastname: Li
authors.forename: Richard M
authors.initials: RM
authors.lastname: Neve
authors.forename: Joe W
authors.initials: JW
authors.lastname: Gray
authors.forename: Wei-Wen
authors.initials: WW
authors.lastname: Cai
authors.forename: Allan
authors.initials: A
authors.lastname: Balmain
mesh_terms: D000818:Animals; D017209:Apoptosis; D064096:Aurora Kinase A; D064127:Aurora Kinases; D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology; D002478:Cells, Cultured; D015536:Down-Regulation; D004622:Embryo, Mammalian / Q000166:cytology / Q000378:metabolism; D005260:Female; D005347:Fibroblasts / Q000166:cytology / Q000378:metabolism; D017353:Gene Deletion; D018628:Gene Dosage; D020869:Gene Expression Profiling; D042822:Genomic Instability; D006579:Heterozygote; D008223:Lymphoma / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D046228:Microarray Analysis; D009381:Neoplasms, Radiation-Induced / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D017346:Protein Serine-Threonine Kinases / Q000235:genetics* / Q000378:metabolism; D015996:Survival Rate; D013953:Thymus Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D016159:Tumor Suppressor Protein p53 / Q000235:genetics / Q000502:physiology*; D014916:Whole-Body Irradiation
chemical_list: D016159:Tumor Suppressor Protein p53; C576918:Aurka protein, mouse; D064096:Aurora Kinase A; D064127:Aurora Kinases; D017346:Protein Serine-Threonine Kinases