title: [Research progress of lipoprotein lipase gene].
abstract: Lipoprotein lipase is a central enzyme in the lipid metabolism, which catalyses the hydrolysis of the triacylglycerol component of chylomicrons and very low density lipoproteins, thereby providing fatty acids and monoacylglycerol for tissue utilisation. LPL gene mutation may affect the activity of LPL, and results in lipid metabolism disorder. It is associated with type 2 diabetes, hypertension, atherosclerosis, obesity and coronary artery disease. Here we review the structure, function, expression regulation of the LPL gene along with its association with complex diseases.
authors.affiliation: College of Life Science, Central China Normal University, Wuhan, China. hsdujk@mails.ccnu.edu.cn
authors.forename: Ji-Kun
authors.initials: JK
authors.lastname: Du
authors.forename: Qing-Yang
authors.initials: QY
authors.lastname: Huang
mesh_terms: D050197:Atherosclerosis / Q000235:genetics; D003324:Coronary Artery Disease / Q000235:genetics; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics; D015971:Gene Expression Regulation, Enzymologic; D006801:Humans; D008071:Lipoprotein Lipase / Q000235:genetics*; D008957:Models, Genetic; D009154:Mutation; D009765:Obesity / Q000235:genetics
chemical_list: D008071:Lipoprotein Lipase