Probing the substrate specificity of the catalytically self-sufficient cytochrome P450 RhF from a Rhodococcus sp.
Analysis of the substrate specificity of the self-sufficient cytochrome P450 RhF revealed that the enzyme tends to catalyse the dealkylation of substituted alkyl-aryl ethers with shorter alkyl moieties more readily than equivalent compounds with longer alkyl groups.
Celik
Ayhan
A
School of Chemistry, University of Edinburgh, The King's Buildings, West Mains Road, Edinburgh, UK.
Roberts
Gareth A
GA
White
John H
JH
Chapman
Stephen K
SK
Turner
Nicholas J
NJ
Flitsch
Sabine L
SL
D000478:Alkylation; D002384:Catalysis; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D004987:Ethers / Q000378:metabolism; D012240:Rhodococcus; D013379:Substrate Specificity
D004987:Ethers; D003577:Cytochrome P-450 Enzyme System