ANCA-associated glomerulonephritis: Relationship of main ANCA subtypes to renal outcome, age and sex of the patients.
BACKGROUND
Antineutrophil cytoplasmic antibodies (ANCA) have been proven to be useful diagnostic tools in patients with systemic vasculitis and glomerulonephritis. These antibodies exist in two types, a cytoplasmic pattern (cANCA) and a perinuclear pattern (pANCA). The effect of the main ANCA subtypes on renal outcome and its relationship to demographic findings and clinical features of patients with ANCA-associated glomerulonephritis has not been adequately studied.


METHODS
In this prospective study, we compared the clinical features at presentation and the renal outcome after 1 year of follow-up between two groups of patients with cANCA (n=22) and pANCA (n=29) consecutively encountered over a one-year period.


RESULTS
At presentation, rapidly progressive glomerulonephritis (RPGN), and after 1 year of follow-up, endstage renal disease (ESRD) were seen more commonly in patients with pANCA than cases with cANCA (P=0.001 and P=0.004, respectively). Seropositivity for cANCA was more common in male and pANCA in female patients (P=0.005). Occurrence of the pulmonary-renal syndrome or extra-renal manifestations, such as sinusitis and skin rash, did not differ significantly among the two groups of patients with cANCA and pANCA.


CONCLUSIONS
Patients with pANCA present more frequently with RPGN, leading to a poorer renal survival compared to cases with cANCA. RPGN and pANCA are more common in females.
Rais-Jalali
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Division of Nephrology, Department of Internal Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Khajehdedi
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