Effect of beta-(1,3)-glucan on rheological properties and stability of topical formulations.
The paper deals with an effect of insoluble fungal beta-(1,3)-glucan on rheological properties of topical preparations. Two types of hydrogels (based on carbomer and polyacrylamide) and two types of hydrocreams (based on polysorbate 80/Span 80 and Brij 721TM/Brij 72) were prepared and investigated. The rheological properties of all these preparations were compared with the properties of placebos and they were measured after preparation and after 5 months of storage under different conditions: at 20 degrees C and 35 degrees C and after a triplicate freeze-thaw cycling process (-20 degrees C/+20 degrees C). In general it can be stated that with the exception of polyacrylamide hydrogel the beta-(1,3)-glucan presence increased the apparent viscosity of assessed preparations by approximately 10-20%. In the case of hydrocreams it was observed that the triplicate freeze-thaw cycling process increased the apparent viscosity of beta-(1,3)-glucan preparations by about 20-30%.
Tichý
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E
Department of pharmaceutical technology, Pharmaceutical Faculty of Comenius University, Odbojarov 10, 832 32 Bratislava, Slovak Republic. edotichy@yahoo.com
Vitková
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Z
Cupková
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B
D000287:Administration, Topical; D004355:Drug Stability; D005079:Excipients; D005615:Freezing; D020100:Hydrogels; D009824:Ointments; D010316:Particle Size; D020076:Pleurotus / Q000737:chemistry; D011136:Polysorbates; D012212:Rheology; D014783:Viscosity; D047071:beta-Glucans / Q000737:chemistry*
D005079:Excipients; D020100:Hydrogels; D009824:Ointments; D011136:Polysorbates; D047071:beta-Glucans; C033363:beta-1,3-glucan