[The influence of changes in the levels of calcitonin gene-related peptide and neuropeptide Y on cardiac function of severe burn patients during shock stage].
OBJECTIVE
To investigate the influence of the changes in the levels of calcitonin gene-related peptide (CGRP) and neuropeptide Y (NPY) on cardiac function of severe burn patients during shock stage.


METHODS
Sixty severe burn patients with total burn surface area larger than 30% were enrolled as experiment group (E group) , and they received fluid resuscitation and debridement during shock stage. Sixty healthy volunteers were enrolled as control group (C group). The changes in the plasma level of CGRP, NPY and cTnT in E and C groups were observed at 1, 3, 6, 12, 24, 48 post-burn hours (PBH). The correlation among the CGRP, NPY and cTnT in the C group were analyzed.


RESULTS
At 3 PBH, the plasma level of CGRP in E group (28 +/- 6) ng/L was lower than that in C group (55 +/- 7) ng/L , and it reached the lowest level at 12 PBH (15 +/- 4)ng/L . It was still lower than that in C group at 48 PBH (P < 0.05). The levels of NPY and cTnT in E group were significantly increased at 1PBH [(136 +/- 20) ng/L, (0.41 +/- 0.08) microg/L] compared with that in C group[ (86 +/- 13) ng/L, (0.16 +/- 0.06) microg/L], peaking at 12PBH [(189 +/- 31) ng/L, (1.78 +/- 0. 47) microg/L], and remaining higher than those in C group at 48PBH. There exhibited obvious negative correlation between the changes in the level of CGRP and cTnT ( r = -0.76, P < 0.01), while obvious positive correlation was found between the changes in level of NPY and cTnT ( r = 0.79, P < 0.01).


CONCLUSIONS
The decrease in CGRP level and the increase in NPY level might play important roles in myocardial injury during shock stage of severe burn patients.
Fang
Lin-sen
LS
Department of Burns , the First Affiliated Hospital , Anhui Medical University, Hefei 230022, P. R. China.
Hu
De-lin
DL
Yu
You-xin
YX
Xu
Qing-lian
QL
Wang
Chun-hua
CH
Wang
Chang-rong
CR
D000328:Adult; D002056:Burns / Q000097:blood / Q000503:physiopathology*; D015740:Calcitonin Gene-Related Peptide / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism; D009478:Neuropeptide Y / Q000097:blood*; D012774:Shock, Traumatic / Q000097:blood / Q000503:physiopathology*; D020107:Troponin T / Q000097:blood
D009478:Neuropeptide Y; D020107:Troponin T; D015740:Calcitonin Gene-Related Peptide