[Forensic pathological significance of immunohistochemical study with CX43 in rats on early myocardial ischaemia].
OBJECTIVE
To explore one of evidence for pathologic diagnosis of early myocardial ischaemia.


METHODS
Rats were ligated of the left coronary artery according to a previously documented technique, and heart tissue was sampled at different ischaemia time. The expression of CX43 in myocardial cell was detected by Immunohistochemistry.


RESULTS
It is showed that the distribution and amount of CX43 positive staining in each group of the myocardial ischaemia was different from that of the control group.


CONCLUSIONS
The changes of CX43 detected by Immunohistochemical methods may be helpful for the diagnosis of early myocardial ischaemia, but further pathologic investigation and research is necessary.
Jin
Li-fang
LF
Institute of Criminal Science, Hangzhou Public Security Bureau, Hangzhou 310031 China.
Chen
Ming-fang
MF
Zheng
Qiang
Q
Xu
Jing-yao
JY
Shen
Yong-hao
YH
Zhu
You-fa
YF
D000818:Animals; D018031:Connexin 43 / Q000378:metabolism*; D004195:Disease Models, Animal; D005260:Female; D049429:Forensic Pathology; D007150:Immunohistochemistry; D008297:Male; D017202:Myocardial Ischemia / Q000378:metabolism* / Q000473:pathology; D032383:Myocytes, Cardiac / Q000378:metabolism*; D009215:Myometrium / Q000378:metabolism / Q000473:pathology*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013194:Staining and Labeling; D013997:Time Factors; D014018:Tissue Distribution
D018031:Connexin 43