title: The efficiency of treatment in patients with uterine-confined endometrial cancer.
abstract: OBJECTIVE
  To present our experience regarding the efficiency of treatment in patients with uterine-confined endometrial cancer.
  
  
  METHODS
  775 patients with uterine-confined endometrial cancer (UCEC) were treated between July 1985 and June 2000 in the Krakow Branch of Sklodowska Memorial Institute.
  
  
  RESULTS
  Among the 775 patients, 5-year disease-free survival was observed in 82.8% patients; 96% patients with low risk of disease recurrence, 93.6% patients with intermediate risk and 78.3% patients with high risk survived five years with no evidence of disease. In the group with a high-risk disease recurrence rate, 5-year disease-free survival was statistically higher among patients treated with adjuvant brachytherapy plus external beam radiotherapy (EBRT) in comparison to patients treated with adjuvant brachytherapy (BRT) alone (82.4% vs 72.1%).
  
  
  CONCLUSIONS
  The recommended treatment in patients with high and moderate differentiation of UCEC with FIGO Stage IA is surgery alone. Surgery with adjuvant EBRT in the group of patients with intermediate risk of cancer recurrence allows over 90% of patients to be cured. In the group of patients with a high risk of disease recurrence adjuvant BRT with EBRT is statistically more efficient in comparison to BRT alone.
authors.affiliation: Department of Gynecologic Oncology, Maria Sklodowska-Curie Memorial Institute, Kraków, Poland.
authors.forename: K
authors.initials: K
authors.lastname: Karolewski
authors.forename: Z
authors.initials: Z
authors.lastname: Kojs
authors.forename: K
authors.initials: K
authors.lastname: Urbański
authors.forename: J
authors.initials: J
authors.lastname: Jakubowicz
authors.forename: P
authors.initials: P
authors.lastname: Blecharz
authors.forename: P
authors.initials: P
authors.lastname: Dymek
authors.forename: M
authors.initials: M
authors.lastname: Reinfuss
mesh_terms: D000230:Adenocarcinoma / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001918:Brachytherapy; D003131:Combined Modality Therapy; D018572:Disease-Free Survival; D016889:Endometrial Neoplasms / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D011859:Radiography; D018714:Radiotherapy, Adjuvant / Q000379:methods; D012189:Retrospective Studies; D018570:Risk Assessment; D016896:Treatment Outcome