Immunomodulatory properties of mesenchymal stem cells: a review based on an interdisciplinary meeting held at the Kennedy Institute of Rheumatology Division, London, UK, 31 October 2005.
Multipotent mesenchymal stromal cells isolated from bone marrow and other sites are currently being studied to determine their potential role in the pathogenesis and/or management of autoimmune diseases. In vitro studies have shown that they exhibit a dose-dependent antiproliferative effect on T and B lymphocytes, dendritic cells, natural killer cells and various B cell tumour lines--an effect that is both cell contact and soluble factor dependent. Animal models of autoimmune disease treated with multipotent mesenchymal stromal cells have mostly exhibited a positive clinical response, as have a limited number of patients suffering from acute graft versus host disease. This review summarizes the findings of a 1-day meeting devoted to the subject with the aim of coordinating efforts.
Tyndall
Alan
A
Rheumatology, University Hospital Basel, Felix Platter Spital, Burgfelderstrasse 101, Basel, CH-4012, Switzerland. alan.tyndall@fps-basel.ch
Walker
Ulrich A
UA
Cope
Andrew
A
Dazzi
Francesco
F
De Bari
Cosimo
C
Fibbe
Willem
W
Guiducci
Serena
S
Jones
Simon
S
Jorgensen
Christian
C
Le Blanc
Katarina
K
Luyten
Frank
F
McGonagle
Dennis
D
Martin
Ivan
I
Bocelli-Tyndall
Chiara
C
Pennesi
Giuseppina
G
Pistoia
Vito
V
Pitzalis
Constantino
C
Uccelli
Antonio
A
Wulffraat
Nico
N
Feldmann
Marc
M
D000818:Animals; D001172:Arthritis, Rheumatoid / Q000276:immunology / Q000601:surgery; D003226:Congresses as Topic / Q000639:trends; D006801:Humans; D007155:Immunologic Factors / Q000276:immunology / Q000627:therapeutic use*; D008131:London; D045164:Mesenchymal Stem Cell Transplantation / Q000379:methods / Q000639:trends; D059630:Mesenchymal Stem Cells / Q000276:immunology*; D012219:Rheumatology / Q000379:methods* / Q000639:trends
D007155:Immunologic Factors