Imaging of iris lesions with high-speed optical coherence tomography.
To image and measure iris tumors with optical coherence tomography (OCT).



High-speed (2,000-4,000 axial-scan/sec and 4-16 frames/sec) 1.3-micron wavelength anterior segment OCT prototypes were used to image 6 eyes of 6 patients with a variety of iris lesions, including focal iris nevus, diffuse iris nevus, amelanotic iris nevus, iris melanocytosis, and iris melanoma. OCT images were compared with slit-lamp photography and ultrasound biomicroscopy.



OCT at 1.3-micron wavelength could penetrate the full thickness of the iris lesions and allow three-dimensional measurement of lesion size. Internal reflectivity is correlated with pigmentation. OCT is a convenient non-contact method that provides imaging of the clinically important angle structures (scleral spur and angle recess).



OCT is a new imaging modality that complements slit-lamp photography and ultrasound biomicroscopy for serial evaluation of iris
Bakri
Sophie J
SJ
From the Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA.
Singh
Arun D
AD
Lowder
Careen Y
CY
Chalita
Maria Regina
MR
Li
Yan
Y
Izatt
Joseph A
JA
Rollins
Andrew M
AM
Huang
David
D
D000328:Adult; D000368:Aged; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007498:Iris / Q000000981:diagnostic imaging / Q000473:pathology*; D015811:Iris Neoplasms / Q000175:diagnosis*; D008297:Male; D008545:Melanoma / Q000175:diagnosis*; D033401:Microscopy, Acoustic; D008875:Middle Aged; D009506:Nevus / Q000175:diagnosis*; D041623:Tomography, Optical Coherence / Q000379:methods*