title: Circadian rhythms in the CNS and peripheral clock disorders: function of clock genes: influence of medication for bronchial asthma on circadian gene.
abstract: Bronchial asthma is a chronic inflammatory disorder of the airways, in which inflammation causes bronchial hyper-responsiveness and flow limitation in the presence of various stimuli. Pulmonary function in asthmatic patients frequently deteriorates between midnight and early morning, which has suggested a role for chronotherapy. Although relationships between bronchial asthma and the function of clock genes remain unclear, some medications given for asthma such as glucocorticoids or beta(2)-adrenoceptor agonists may influence clock genes in vivo. In our studies of clock gene mRNA expressions in human bronchial epithelial cells in vitro and peripheral blood cells in vivo, we demonstrated that glucocorticoid or beta(2)-adrenoceptor agonist treatment strongly induced human Per1 mRNA expression both in vitro and in vivo. Human peripheral blood cells provide a useful indication of peripheral clock gene mRNA expression in vivo.
authors.affiliation: Division of Medical Oncology and Molecular Respirology, Faculty of Medicine, Tottori University, 36-1 Nishimachi, Yonago 683-8504, Japan. burioka@grape.med.tottori-u.ac.jp
authors.forename: Naoto
authors.initials: N
authors.lastname: Burioka
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Fukuoka
authors.forename: Miyako
authors.initials: M
authors.lastname: Takata
authors.forename: Masahiro
authors.initials: M
authors.lastname: Endo
authors.forename: Masanori
authors.initials: M
authors.lastname: Miyata
authors.forename: Hiroki
authors.initials: H
authors.lastname: Chikumi
authors.forename: Katsuyuki
authors.initials: K
authors.lastname: Tomita
authors.forename: Masahiro
authors.initials: M
authors.lastname: Kodani
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Touge
authors.forename: Kenichi
authors.initials: K
authors.lastname: Takeda
authors.forename: Takashi
authors.initials: T
authors.lastname: Sumikawa
authors.forename: Kousuke
authors.initials: K
authors.lastname: Yamaguchi
authors.forename: Yasuto
authors.initials: Y
authors.lastname: Ueda
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Nakazaki
authors.forename: Hisashi
authors.initials: H
authors.lastname: Suyama
authors.forename: Akira
authors.initials: A
authors.lastname: Yamasaki
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Sano
authors.forename: Tadashi
authors.initials: T
authors.lastname: Igishi
authors.forename: Eiji
authors.initials: E
authors.lastname: Shimizu
mesh_terms: D000818:Animals; D001249:Asthma / Q000235:genetics* / Q000503:physiopathology*; D001683:Biological Clocks / Q000235:genetics* / Q000502:physiology*; D002490:Central Nervous System / Q000502:physiology*; D002940:Circadian Rhythm / Q000235:genetics* / Q000502:physiology*; D006801:Humans; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D018343:Receptors, Adrenergic, beta-2 / Q000235:genetics / Q000502:physiology
chemical_list: D012333:RNA, Messenger; D018343:Receptors, Adrenergic, beta-2