[The efficacy of oxynicotinic acid a nd its derivatives in respect of functional activity of hepatocytes during acute toxic hepatopathy].
Hepatoprotective activity of oxynicotinic acid and its derivatives XC-2, XC-2, XC-4, XC-9 in destructive processes in the liver induced by CCl4 injection has been studied. It was found in that injection of oxynicotinic acid derivatives in toxic lesion of the liver decreases cytolysis, cholestasis, hepatodepressive and mesenchymal-inflammatory syndromes. Membrane-stabilizing and antioxidant effects of oxynicotinic acid derivatives increase in the following sequence: XC-1 --> XC-2, XC-3 --> XC-4, mexidol --> XC-9.
Avdeeva
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Konoplia
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Sernov
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D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002251:Carbon Tetrachloride / Q000633:toxicity; D056486:Chemical and Drug Induced Liver Injury / Q000517:prevention & control*; D004195:Disease Models, Animal; D022781:Hepatocytes / Q000187:drug effects*; D009525:Niacin / Q000031:analogs & derivatives* / Q000494:pharmacology*; D010847:Picolines / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar
D000975:Antioxidants; D010847:Picolines; D009525:Niacin; C070020:emoxypine succinate; D002251:Carbon Tetrachloride