Preliminary evidence of glycogen synthase kinase 3 beta as a genetic determinant of polycystic ovary syndrome.
In this study of 352 women with polycystic ovary syndrome (PCOS) and 289 control women, haplotypes spanning the gene for glycogen synthase kinase 3beta (GSK3B) were constructed on the basis of nine single-nucleotide polymorphisms in white and black subjects separately. In each racial group, we observed that a specific, although different, GSK3B haplotype was associated with increased frequency of PCOS, suggesting that GSK3beta contributes to the pathophysiology and inherited basis of PCOS.
Goodarzi
Mark O
MO
Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA.
Antoine
Heath J
HJ
Pall
Marita
M
Cui
Jinrui
J
Guo
Xiuqing
X
Azziz
Ricardo
R
D044383:Black People / Q000235:genetics; D017931:DNA Primers; D005260:Female; D005787:Gene Frequency; D038362:Glycogen Synthase Kinase 3 / Q000235:genetics*; D000071679:Glycogen Synthase Kinase 3 beta; D006801:Humans; D011085:Polycystic Ovary Syndrome / Q000201:enzymology / Q000235:genetics*; D016133:Polymerase Chain Reaction; D012016:Reference Values; D044465:White People / Q000235:genetics
D017931:DNA Primers; C000605506:GSK3B protein, human; D000071679:Glycogen Synthase Kinase 3 beta; D038362:Glycogen Synthase Kinase 3