title: Transmission of drug-resistant tuberculosis among treated patients in Shanghai, China.
abstract: We sought to determine whether patients who had therapy failure with increasingly drug-resistant strains of tuberculosis had primary or acquired drug resistance, by genotyping the initial and subsequent drug-resistant clinical isolates of Mycobacterium tuberculosis collected from patients by the Shanghai Centers for Disease Control and Prevention over the course of a 5-year period. The vast majority of patients (27/32) had primary drug resistance, indicating transmission of a drug-resistant strain of M. tuberculosis. Only 16% (5/32) had acquired drug resistance because of a poor treatment regimen or nonadherence to an adequate regimen. Our findings highlight the urgency of increasing efforts to interrupt the transmission of drug-resistant tuberculosis in communities and facilities in Shanghai, China.
authors.affiliation: Key Laboratory of Medical Molecular Virology, Shanghai Medical College, Shanghai, 200032, China.
authors.forename: Xia
authors.initials: X
authors.lastname: Li
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhang
authors.forename: Xin
authors.initials: X
authors.lastname: Shen
authors.forename: Guomiao
authors.initials: G
authors.lastname: Shen
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Gui
authors.forename: Bin
authors.initials: B
authors.lastname: Sun
authors.forename: Jian
authors.initials: J
authors.lastname: Mei
authors.forename: Kathryn
authors.initials: K
authors.lastname: Deriemer
authors.forename: Peter M
authors.initials: PM
authors.lastname: Small
authors.forename: Qian
authors.initials: Q
authors.lastname: Gao
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000995:Antitubercular Agents / Q000494:pharmacology; D002681:China / Q000453:epidemiology; D024881:Drug Resistance, Bacterial; D005260:Female; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D009169:Mycobacterium tuberculosis / Q000145:classification / Q000187:drug effects / Q000302:isolation & purification*; D010349:Patient Compliance; D013183:Sputum / Q000382:microbiology; D014376:Tuberculosis / Q000188:drug therapy* / Q000453:epidemiology / Q000635:transmission*
chemical_list: D000995:Antitubercular Agents