Imaging cerebral amyloid angiopathy with susceptibility-weighted imaging.
Gradient-echo (GE) imaging is recognized as a means to detect hemorrhagic changes in cerebral amyloid angiopathy (CAA). However, almost 25% of patients with CAA do not show microhemorrhages on T2* GE imaging. We applied a new imaging method, susceptibility weighted imaging (SWI), to evaluate the presence of microhemorrhages. In a suspected case of CAA, where cognitive effects are also present, we show that SWI is much more sensitive in detecting microhemorrhages than conventional methods.
Haacke
E M
EM
Institute for Biomedical Research, Detroit, Mich, USA.
DelProposto
Z S
ZS
Chaturvedi
S
S
Sehgal
V
V
Tenzer
M
M
Neelavalli
J
J
Kido
D
D
D000368:Aged; D016657:Cerebral Amyloid Angiopathy / Q000473:pathology*; D002544:Cerebral Infarction / Q000473:pathology*; D002560:Cerebrovascular Circulation; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008833:Microcirculation