Synthesis of functionalized carboranes as potential anticancer and BNCT agents.
Carboranyl aldehydes react with alpha,beta-unsaturated esters, ketones, and nitriles in the presence of DABCO to provide functionalized carboranyl alcohols in good yields. Acetates of these alcohols undergo a facile isomerization with a variety of nucleophiles and afford structurally interesting carboranes. Biological evaluation of these molecules exhibited impressive antiproliferative activity for brain and breast cancer cells.
Reddy
Venkata Jaganmohan
VJ
Department of Chemistry, University of Minnesota at Duluth, Chem 233, 1039 University Drive, Duluth, Minnesota 55812, USA.
Roforth
Matthew M
MM
Tan
Chalet
C
Reddy
M Venkat Ram
MV
D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D001896:Boron Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D016754:Boron Neutron Capture Therapy; D007536:Isomerism
D000970:Antineoplastic Agents; D001896:Boron Compounds