Nitric oxide levels and the severity of juvenile idiopathic arthritis.
In this study, we evaluate the distribution of nitric oxide (NO) in the serum of juvenile idiopathic arthritis (JIA) patients, correlating it with parameters of the severity of the disease. Ninety-seven patients with mean age 11.7 years and disease duration 4.8 years, showing active disease or not, grouped as oligoarticular (n = 34), polyarticular (n = 29) and systemic (n = 34) group, presenting uveitis and positive RF with erosive arthritis or active disease and erosions had significantly high levels of NO than the inactive ones. NO correlated with TNF-alpha in the oligoarticular subtype (P < 0.03), with pain in the polyarticular subtype with active disease (P < 0.04) and with ESR in the systemic subtype with active disease (P < 0.03). TNF-alpha concentration was high in all patients with active disease, accompanying NO production. The data confirm the production of NO in JIA patients, indicating a possible positive correlation between the production of NO and severity of the disease.
Bica
Blanca Elena R G
BE
Clínica de Reumatologia, Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Gomes
Niele M
NM
Fernandes
Patrícia D
PD
Luiz
Ronir R
RR
Koatz
Vera Lúcia G
VL
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D001171:Arthritis, Juvenile / Q000097:blood* / Q000175:diagnosis* / Q000503:physiopathology; D001175:Arthrography; D015415:Biomarkers / Q000032:analysis / Q000097:blood; D002634:Chemotaxis, Leukocyte / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D018450:Disease Progression; D005260:Female; D006801:Humans; D007596:Joints / Q000276:immunology / Q000473:pathology / Q000503:physiopathology; D007962:Leukocytes / Q000276:immunology / Q000378:metabolism; D008297:Male; D009569:Nitric Oxide / Q000032:analysis / Q000097:blood* / Q000276:immunology*; D011237:Predictive Value of Tests; D013223:Statistics as Topic; D013583:Synovial Membrane / Q000276:immunology / Q000473:pathology / Q000503:physiopathology; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis / Q000097:blood / Q000276:immunology; D014605:Uveitis / Q000276:immunology
D015415:Biomarkers; D014409:Tumor Necrosis Factor-alpha; D009569:Nitric Oxide