Post-surgical meningitis due to multiresistant Acinetobacter baumannii. Effective treatment with intravenous and/or intraventricular colistin and therapeutic dilemmas.
Post-surgical meningitis and/or ventriculitis caused by Gram-negative bacteria may be difficult to treat due to the emergence of multiresistant strains. Two patients with multiresistant Acinetobacter baumannii central nervous system infection, successfully treated with either intravenous and/or intraventricular colistin are presented. Unresolved issues such as dose and duration of intraventricular colistin are discussed.
Paramythiotou
E
E
Intensive Care Unit, George-Gennimatas General State Hospital of Athens, Mesogion, 154, Holargos, Athens, Greece. lparamyth61@hotmail.com
Karakitsos
D
D
Aggelopoulou
H
H
Sioutos
P
P
Samonis
G
G
Karabinis
A
A
D000151:Acinetobacter Infections / Q000188:drug therapy / Q000382:microbiology*; D040981:Acinetobacter baumannii / Q000187:drug effects* / Q000302:isolation & purification; D000328:Adult; D017542:Aneurysm, Ruptured / Q000601:surgery; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D003091:Colistin / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D006259:Craniocerebral Trauma / Q000150:complications; D003428:Cross Infection / Q000188:drug therapy / Q000382:microbiology*; D020878:Device Removal; D024901:Drug Resistance, Multiple, Bacterial; D005260:Female; D006801:Humans; D006849:Hydrocephalus / Q000209:etiology / Q000601:surgery; D007276:Injections, Intraventricular; D002532:Intracranial Aneurysm / Q000601:surgery; D008297:Male; D011183:Postoperative Complications / Q000188:drug therapy / Q000382:microbiology*; D017287:Ventriculoperitoneal Shunt / Q000009:adverse effects
D000900:Anti-Bacterial Agents; D003091:Colistin