Transformed follicular lymphoma with concurrent t(2;3), t(8;14) and t(14;18).
An elderly Chinese man who had an 8-year history of follicular lymphoma presented with large B-cell lymphoma. The disease ran a rapidly fatal course with a terminal leukemic phase. Cytogenetic analysis of the transformed follicular lymphoma showed a complex karyotype of 48,Y,t(X;19)(q26;p13.3),t(2;3)(p12;q27),t(8;14)(q24.1;q32),+12,t(14;18)(q32;q21),+21. To my knowledge, this is the first reported case of simultaneous occurrence of t(2;3), t(8;14), and t(14;18) in transformed follicular lymphoma.
Wong
K F
KF
Department of Pathology, Queen Elizabeth Hospital, 30 Gascoigne Road, Kowloon, Hong Kong SAR, China. kfwong@ha.org.hk
D000368:Aged; D002871:Chromosome Banding; D002883:Chromosomes, Human, Pair 14; D002887:Chromosomes, Human, Pair 18; D002889:Chromosomes, Human, Pair 2; D002893:Chromosomes, Human, Pair 3; D002898:Chromosomes, Human, Pair 8; D017809:Fatal Outcome; D006801:Humans; D007621:Karyotyping; D008224:Lymphoma, Follicular / Q000175:diagnosis / Q000235:genetics*; D008297:Male; D014178:Translocation, Genetic / Q000235:genetics*