[Correction of mitochondrial respiration processes in rats with different resistance to hypoxia under stress by modulators of ATP-sensitive potassium channels].
The effects of the activator of ATP-sensitive potassium channels (K(ATP)) pinacidil (0.06 mg/kg) and the blocker of these channels glibenclamide (1 mg/kg) were investigated using liver and heart mitochondria isolated from rats exhibiting high (HR) or low-resistance (LR) to hypoxia. The animals were subjected to emotional stress. Stress caused activation of mitochondrial succinate oxidation, the decrease of efficiency of alpha-ketoglutarate oxidation and intensification of lipid peroxidation (LPO). These changes were more pronounced in the LR-animals. Administration of pinacidil protected mitochondria under conditions of stress, of whereas glibenclamide abolished these changes.
Kurgaliuk
N N
NN
Tkachenko
G M
GM
D000818:Animals; D019069:Cell Respiration / Q000187:drug effects; D005905:Glyburide / Q000494:pharmacology; D007004:Hypoglycemic Agents / Q000494:pharmacology; D000860:Hypoxia / Q000378:metabolism*; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008929:Mitochondria, Heart / Q000378:metabolism*; D008930:Mitochondria, Liver / Q000378:metabolism*; D010084:Oxidation-Reduction / Q000187:drug effects; D020110:Pinacidil / Q000494:pharmacology; D026902:Potassium Channel Blockers / Q000494:pharmacology; D015221:Potassium Channels / Q000819:agonists / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D013315:Stress, Psychological / Q000378:metabolism*; D019802:Succinic Acid / Q000378:metabolism; D014665:Vasodilator Agents / Q000494:pharmacology*
D007004:Hypoglycemic Agents; D026902:Potassium Channel Blockers; D015221:Potassium Channels; D014665:Vasodilator Agents; D020110:Pinacidil; D019802:Succinic Acid; D005905:Glyburide