title: A simple absorption model for dose-escalating studies.
abstract: A simple model for absorption that generalizes zero and first order absorption processes is discussed. We show how traditional methods can be used to investigate how reasonable this model is, and discuss the effects of the absorption model on classical PK parameters. The methods are illustrated with two real-life data sets from dose-escalating studies.
authors.affiliation: Department of Biostatistics, AstraZeneca R&D, Jullovsvñgen 13, Lund, 224 67, Sweden. anders.kallen@astrazeneca.com
authors.forename: Anders
authors.initials: A
authors.lastname: Källén
mesh_terms: D000284:Administration, Oral; D015507:Drugs, Investigational / Q000008:administration & dosage / Q000493:pharmacokinetics*; D006801:Humans; D007408:Intestinal Absorption; D008954:Models, Biological; D015203:Reproducibility of Results
chemical_list: D015507:Drugs, Investigational