title: DNA methylation with a sting: an active DNA methylation system in the honeybee.
abstract: The existence of DNA methylation in insects has been a controversial subject over a long period of time. The recently completed genome sequence of the honeybee Apis mellifera has revealed the first insect with a full complement of DNA methyltransferases. A parallel study demonstrated that these enzymes are catalytically active and that Apis genes can be methylated in specific patterns. These findings establish bees as a model to analyze the function of DNA methylation systems in invertebrate organisms and might also be important to understand evolutionary aspects of DNA methylation in higher eukaryotes.
authors.affiliation: Division of Epigenetics, Deutsches Krebsforschungszentrum, Heidelberg, Germany.
authors.forename: Matthias
authors.initials: M
authors.lastname: Schaefer
authors.forename: Frank
authors.initials: F
authors.lastname: Lyko
mesh_terms: D000818:Animals; D001516:Bees / Q000201:enzymology* / Q000235:genetics*; D019175:DNA Methylation; D015254:DNA Modification Methylases; D019143:Evolution, Molecular; D010802:Phylogeny
chemical_list: D015254:DNA Modification Methylases