title: Endothelium-microenvironment interactions in the developing embryo and in the adult.
abstract: The vascular endothelium is best known for its role in oxygen and nutrient delivery to the various tissues. Growing evidence supports a far more complex role in tissue homeostasis. In particular, reciprocal interactions between endothelial cells and the local microenvironment may regulate organ development and pattern formation. Such interactions appear to be important also in the adult, in normal and pathological conditions.
authors.affiliation: Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
authors.forename: Kristy
authors.initials: K
authors.lastname: Red-Horse
authors.forename: Yongping
authors.initials: Y
authors.lastname: Crawford
authors.forename: Farbod
authors.initials: F
authors.lastname: Shojaei
authors.forename: Napoleone
authors.initials: N
authors.lastname: Ferrara
mesh_terms: D000328:Adult; D000818:Animals; D001808:Blood Vessels / Q000196:embryology*; D004622:Embryo, Mammalian / Q000098:blood supply* / Q000196:embryology*; D004730:Endothelium, Vascular / Q000196:embryology* / Q000378:metabolism*; D006801:Humans; D009369:Neoplasms / Q000098:blood supply / Q000473:pathology; D009928:Organ Specificity; D015398:Signal Transduction