Pd-catalysed [3 + 3] annelations in the stereoselective synthesis of indolizidines.
A [3 + 3] annelation of enantiomerically pure aziridine 7 provides the functionalised piperidine 8 that can be elaborated to the indolizidine skeleton in only 4 steps with good stereocontrol.
Provoost
Olivier Y
OY
Department of Chemistry, University of Sheffield, Brook Hill, Sheffield, S3 7HF, UK. olivier.provoost@syngenta.com
Hazelwood
Andrew J
AJ
Harrity
Joseph P A
JP