The role of ThinPrep cytology in the investigation of lung tumors.
OBJECTIVE
The aim of this study was to evaluate the role of liquid-based cytology with the ThinPrep (TP) (Cytyc; Cytyc, Co, Boxborough, MA, USA) technique, using fine-needle aspiration (FNA) for sampling, in the investigation of suspicious pulmonary lesions.


METHODS
We performed percutaneous computed tomography (CT)-guided FNA biopsy of focal pulmonary lesions in 80 adult patients. Study subjects were all consecutive patients and potential candidates for surgery. The sample was then examined by both conventional smears (CS) and TP techniques. TP smears of all FNA were prepared from needle rinsing obtained following preparation of CS. All cytological diagnoses were correlated with the CS and/or thoracotomy histological diagnoses in order to evaluate the role of liquid-based cytology with the TP technique.


RESULTS
Using TP technique diagnosis was successfully established in 75 patients out of 80, whereas using CS cytology diagnosis was established in 54 patients (p<0.001, z=3899). Inadequate material was observed in 5 cases (6.25%) with the TP technique and in 13 cases (16.25%) with the CS technique (z=-2.77, p<0.05).


CONCLUSIONS
We believe that the TP technique has a good overall yield for the diagnosis of suspicious for malignant lung lesions. We found that the accuracy of determining lung cancer was excellent.
Konofaos
P
P
International Institute of Reconstructive Microsurgery-Eastern Virginia Medical School, Julia K Terzis MD Ltd., 330 West Brambleton Avenue, Suite 1, Norfolk, VI 23510, USA. petros_konofaos@yahoo.com
Tomos
P
P
Malagari
K
K
Karakatsani
A
A
Pavlopoulos
D
D
Lachanas
E
E
Flessas
M
M
Kostakis
A
A
Karakitsos
P
P
D002277:Carcinoma / Q000175:diagnosis; D003581:Cytodiagnosis / Q000379:methods*; D005260:Female; D006222:Hamartoma / Q000175:diagnosis; D006801:Humans; D008168:Lung / Q000473:pathology*; D008175:Lung Neoplasms / Q000175:diagnosis*; D008228:Lymphoma, Non-Hodgkin / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D015641:Radiography, Interventional; D014057:Tomography, X-Ray Computed