title: Tissue microarrays characterise the clinical significance of a VEGF-A protein expression signature in gastrointestinal stromal tumours.
abstract: A tissue microarray analysis of 22 proteins in gastrointestinal stromal tumours (GIST), followed by an unsupervised, hierarchical monothetic cluster statistical analysis of the results, allowed us to detect a vascular endothelial growth factor (VEGF) protein overexpression signature discriminator of prognosis in GIST, and discover novel VEGF-A DNA variants that may have functional significance.
authors.affiliation: Department of Pathology, Yong Loo Lin Faculty of Medicine, National University of Singapore, 5 Lower Kent Ridge Road, Singapore. patmst@nus.edu.sg
authors.forename: M
authors.initials: M
authors.lastname: Salto-Tellez
authors.forename: M E
authors.initials: ME
authors.lastname: Nga
authors.forename: H C
authors.initials: HC
authors.lastname: Han
authors.forename: A S-C
authors.initials: AS
authors.lastname: Wong
authors.forename: C K
authors.initials: CK
authors.lastname: Lee
authors.forename: D
authors.initials: D
authors.lastname: Anuar
authors.forename: S S
authors.initials: SS
authors.lastname: Ng
authors.forename: M
authors.initials: M
authors.lastname: Ho
authors.forename: A
authors.initials: A
authors.lastname: Wee
authors.forename: Y H
authors.initials: YH
authors.lastname: Chan
authors.forename: R
authors.initials: R
authors.lastname: Soong
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001483:Base Sequence; D002851:Chromatography, High Pressure Liquid; D016000:Cluster Analysis; D004252:DNA Mutational Analysis; D017931:DNA Primers; D046152:Gastrointestinal Stromal Tumors / Q000235:genetics / Q000378:metabolism* / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D008969:Molecular Sequence Data; D009154:Mutation; D016133:Polymerase Chain Reaction; D011379:Prognosis; D040081:Protein Array Analysis; D046888:Tissue Array Analysis; D042461:Vascular Endothelial Growth Factor A / Q000096:biosynthesis* / Q000235:genetics*
chemical_list: D017931:DNA Primers; D042461:Vascular Endothelial Growth Factor A