Late-onset self-healing reticulohistiocytosis: pediatric case of Hashimoto-Pritzker type Langerhans cell histiocytosis.
An 8-year-old otherwise healthy girl presented with a 3-month history of multiple asymptomatic, reddish-brown papules over the face and upper limbs. Histopathological and immunohistochemical examinations demonstrated an infiltrate of mononuclear cells containing abundant histiocytic cells in the dermis, and microabscess-like accumulation of the histiocytic cells in the epidermis. The histiocytic cells were positive for antibodies against S-100 protein and CD1a, but negative for anti-CD68. Lag and anti-langerin monoclonal antibodies reacted more weakly with these histiocytic cells than with Langerhans cells in the surrounding epidermis. The skin lesions spontaneously regressed within the following 3 months, and neither systemic involvement nor local recurrence was observed during the next 10 months. This case should be categorized as congenital self-healing reticulohistiocytosis (Hashimoto-Pritzker), although the onset was not early in life.
Nakahigashi
Kyoko
K
Department of Dermatology, Osaka Red Cross Hospital, Ten'noji-ku, Osaka, Japan.
Ohta
Miyuki
M
Sakai
Rie
R
Sugimoto
Yasushi
Y
Ikoma
Yukiko
Y
Horiguchi
Yuji
Y
D017668:Age of Onset; D001132:Arm / Q000473:pathology; D002648:Child; D005145:Face / Q000473:pathology; D005260:Female; D006644:Histiocytes / Q000276:immunology / Q000473:pathology; D006646:Histiocytosis, Langerhans-Cell / Q000473:pathology*; D006801:Humans; D007801:Langerhans Cells / Q000276:immunology / Q000473:pathology; D012867:Skin / Q000473:pathology*