Synthesis and antimicrobial activity of some novel phenyl and benzimidazole substituted benzyl ethers.
In this study, a series of novel phenyl- and benzimidazole-substituted benzyl ethers were synthesized and evaluated for antibacterial and antifungal activities against Staphylococcus aureus, Methicillin-resistant S. aureus (MRSA), Escherichia coli, Candida albicans, and Candida krusei. Compound 6g exhibited the most potent antibacterial activity with lowest MIC values of 3.12 and 6.25 microg/mL against S. aureus and MRSA, respectively.
Güven
Ozden Ozel
OO
Department of Chemistry, Zonguldak Karaelmas University, 67100 Zonguldak, Turkey. ozdenozel_guven@yahoo.com
Erdoğan
Taner
T
Göker
Hakan
H
Yildiz
Sulhiye
S
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000494:pharmacology; D001562:Benzimidazoles; D001593:Benzyl Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D024881:Drug Resistance, Bacterial / Q000187:drug effects; D004987:Ethers; D008712:Methicillin; D008826:Microbial Sensitivity Tests; D010636:Phenols; D013211:Staphylococcus aureus / Q000187:drug effects
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000935:Antifungal Agents; D001562:Benzimidazoles; D001593:Benzyl Compounds; D004987:Ethers; D010636:Phenols; D008712:Methicillin