Development and selection of gammadelta T cells.
Two main lineages of T cells develop in the thymus: those that express the alphabeta T-cell receptor (TCR) and those that express the gammadelta TCR. Whereas the development, selection, and peripheral localization of newly differentiated alphabeta T cells are understood in some detail, these processes are less well characterized in gammadelta T cells. This review describes research carried out in this laboratory and others, which addresses several key aspects of gammadelta T-cell development, including the decision of precursor cells to differentiate into the gammadelta versus alphabeta lineage, the ordered differentiation over the course of ontogeny of functional gammadelta T-cell subsets expressing distinct TCR structures, programming of ordered Vgamma gene rearrangement in the thymus, including a molecular switch that ensures appropriate Vgamma rearrangements at the appropriate stage of development, positive selection in the thymus of gammadelta T cells destined for the epidermis, and the acquisition by developing gammadelta T cells of cues that determine their correct localization in the periphery. This research suggests a coordination of molecularly programmed events and cellular selection, which enables specialization of the thymus for production of distinct T-cell subsets at different stages of development.
Xiong
Na
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Department of Molecular and Cell Biology, Cancer Research Laboratory, University of California, Berkeley, CA, USA.
Raulet
David H
DH
D000818:Animals; D002454:Cell Differentiation / Q000276:immunology*; D019070:Cell Lineage / Q000276:immunology; D015332:Gene Rearrangement, alpha-Chain T-Cell Antigen Receptor; D015333:Gene Rearrangement, beta-Chain T-Cell Antigen Receptor; D016694:Gene Rearrangement, delta-Chain T-Cell Antigen Receptor; D015334:Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor; D006801:Humans; D008213:Lymphocyte Activation / Q000276:immunology; D051379:Mice; D018448:Models, Immunological; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000235:genetics / Q000276:immunology; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000235:genetics / Q000276:immunology*; D016176:T-Lymphocyte Subsets / Q000166:cytology* / Q000276:immunology*
D016693:Receptors, Antigen, T-Cell, alpha-beta; D016692:Receptors, Antigen, T-Cell, gamma-delta