title: Deep gray matter perfusion in multiple sclerosis: dynamic susceptibility contrast perfusion magnetic resonance imaging at 3 T.
abstract: OBJECTIVE
  To assess the presence of perfusion abnormalities in the deep gray matter of patients with relapsing-remitting and primary progressive multiple sclerosis (MS) in comparison with healthy controls and to investigate the impact of perfusion impairment on clinical disability and fatigue.
  
  
  METHODS
  Survey.
  
  
  METHODS
  Research-oriented hospital. Patients Twenty-two patients with MS and 11 age- and sex-matched healthy volunteers. Intervention Absolute cerebral blood flow, cerebral blood volume, and mean transit time were measured in the thalamus, putamen, and caudate nuclei.
  
  
  METHODS
  Decrease of cerebral blood flow in the deep gray matter of patients with MS and correlation between perfusion impairment and the severity of fatigue.
  
  
  RESULTS
  The cerebral blood flow value averaged over the thalamus, putamen, and caudate nuclei was significantly lower in patients with primary progressive MS (P<.001) and in patients with relapsing-remitting MS (P = .01) compared with controls, and there was a trend for patients with primary progressive MS to have lower average cerebral blood flow than patients with relapsing-remitting MS (P = .06). With respect to cerebral blood volume, there was a significant difference between patients with primary progressive MS and controls (P<.001) and between the 2 groups of patients (P = .03) but not between patients with relapsing-remitting MS and controls (P>.30). The fatigue score was significantly correlated with cerebral blood flow (r = 0.4; P<.001) and cerebral blood volume (r = 0.5; P = .004).
  
  
  CONCLUSIONS
  The decrease of tissue perfusion in the deep gray matter of patients with MS is associated with the severity of fatigue.
authors.affiliation: Departments of Radiology and Neurology, Hospital for Joint Disease, New York University School of Medicine, 650 First Avenue, New York, NY 10016, USA. matilde.inglese@med.nyu.edu
authors.forename: Matilde
authors.initials: M
authors.lastname: Inglese
authors.forename: Sun-Jung
authors.initials: SJ
authors.lastname: Park
authors.forename: Glyn
authors.initials: G
authors.lastname: Johnson
authors.forename: James S
authors.initials: JS
authors.lastname: Babb
authors.forename: Laura
authors.initials: L
authors.lastname: Miles
authors.forename: Hina
authors.initials: H
authors.lastname: Jaggi
authors.forename: Joseph
authors.initials: J
authors.lastname: Herbert
authors.forename: Robert I
authors.initials: RI
authors.lastname: Grossman
mesh_terms: D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D001783:Blood Flow Velocity; D001810:Blood Volume; D016022:Case-Control Studies; D002560:Cerebrovascular Circulation; D004198:Disease Susceptibility; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D016014:Linear Models; D018810:Magnetic Resonance Angiography; D008297:Male; D008875:Middle Aged; D020528:Multiple Sclerosis, Chronic Progressive / Q000503:physiopathology*; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000503:physiopathology*