Caspofungin in the treatment of symptomatic candiduria.
BACKGROUND
Because the urine concentrations achieved by echinocandin antifungal agents are low, drugs from this class are excluded from consideration when candiduria treatment is selected.


METHODS
We performed a retrospective view (sponsored by Merck Research Laboratories) of case records of patients participating in phase II-III clinical studies of caspofungin to identify patients with candiduria.


RESULTS
Of 12 case records collected by Merck Research Laboratories, 6 met the criteria for significant candiduria, allowing the evaluation of caspofungin therapy as judged by J.D.S. Three reported cases of candiduria secondary to hematogenous renal candidiasis were promptly eradicated. Of greater significance are 3 cases of complicated, ascending Candida glabrata infection (i.e., C. glabrata infection plus renal insufficiency), which were successfully treated with caspofungin.


CONCLUSIONS
Caspofungin may have a role in treating complicated Candida urinary tract infections, especially when the infection is caused by non-albicans species of Candida.
Sobel
Jack D
JD
Department of Medicine, Wayne State University School of Medicine, Detroit, MI, USA. jsobel@med.wayne.edu
Bradshaw
Susan K
SK
Lipka
C Joy
CJ
Kartsonis
Nicholas A
NA
D000368:Aged; D000892:Anti-Infective Agents, Urinary / Q000627:therapeutic use*; D000935:Antifungal Agents / Q000627:therapeutic use*; D001437:Bacteriuria / Q000175:diagnosis / Q000188:drug therapy*; D002175:Candida / Q000187:drug effects; D002177:Candidiasis / Q000175:diagnosis / Q000188:drug therapy* / Q000652:urine; D000077336:Caspofungin; D017322:Clinical Trials, Phase II as Topic; D017326:Clinical Trials, Phase III as Topic; D054714:Echinocandins; D005260:Female; D006801:Humans; D055666:Lipopeptides; D008297:Male; D008875:Middle Aged; D010456:Peptides, Cyclic / Q000627:therapeutic use*; D012189:Retrospective Studies
D000892:Anti-Infective Agents, Urinary; D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D010456:Peptides, Cyclic; D000077336:Caspofungin