Antiadhesive effect of the mixed solution of sodium hyaluronate and sodium carboxymethylcellulose after endoscopic sinus surgery.
BACKGROUND
We evaluated the clinical efficacy and safety of the mixed solution of sodium hyaluronate and sodium carboxymethylcellulose (HA-CMC) for prevention of adhesion after endoscopic sinus surgery.


METHODS
Preoperative computed tomography (CT) scans were graded. At the completion of surgery, HA-CMC was applied to Merocel and repeatedly applied after the removal of Merocel. As a control, normal saline was applied. Endoscopic examination was performed postoperatively and grading was done.


RESULTS
The rate of adhesion was the highest at 2 weeks postoperatively and was significantly lower in the HA-CMC-treated group than the control on all postoperative days. The grouping of cases by CT scores at 2 weeks postoperatively showed lower adhesion formation with the HA-CMC treatment than the control. The safety profile of the patients was normal at 4 weeks postoperatively.


CONCLUSIONS
HA-CMC is an efficacious and safe material in decreasing the incidence of adhesion after endoscopic sinus surgery.
Kim
Jeong Hong
JH
Department of Otorhinolaryngology, Brain Korea 21 Project for Medical Science, Seoul, South Korea.
Lee
Joo-Hwan
JH
Yoon
Joo-heon
JH
Chang
Jung Hyun
JH
Bae
Jung Ho
JH
Kim
Kyung-Su
KS
D000268:Adhesiveness / Q000187:drug effects; D000276:Adjuvants, Immunologic / Q000008:administration & dosage / Q000627:therapeutic use*; D000293:Adolescent; D000328:Adult; D002266:Carboxymethylcellulose Sodium / Q000008:administration & dosage / Q000627:therapeutic use*; D004338:Drug Combinations; D004724:Endoscopy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006820:Hyaluronic Acid / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D011182:Postoperative Care / Q000379:methods*; D011183:Postoperative Complications / Q000517:prevention & control*; D012189:Retrospective Studies; D012852:Sinusitis / Q000000981:diagnostic imaging / Q000601:surgery*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
D000276:Adjuvants, Immunologic; D004338:Drug Combinations; D006820:Hyaluronic Acid; D002266:Carboxymethylcellulose Sodium