Role of endothelial-derived nitric oxide in hypertension and renal disease.
OBJECTIVE
To highlight recent advances in the field of endothelial-derived nitric oxide regulation of blood pressure and renal homeostasis.


RESULTS
Many laboratories have dissected a role for nitric oxide in regulating blood pressure and renal function. In models of hypertension, and chronic and acute renal disease, the loss of nitric oxide bioavailability may occur due to inactivation of endothelial nitric oxide synthase, synthesis of endogenous inhibitors or oxidative inactivation of nitric oxide.


CONCLUSIONS
Understanding the molecular mechanisms of nitric oxide synthesis may lead to novel diagnostics and treatments for cardiovascular disorders.
Marin
Ethan
E
Departments of Pharmacology and Nephrology and Program in Vascular Biology and Transplantation, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut 06536, USA.
Sessa
William C
WC
D058186:Acute Kidney Injury / Q000503:physiopathology*; D051242:Caveolin 1 / Q000502:physiology*; D004727:Endothelium / Q000378:metabolism; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D007676:Kidney Failure, Chronic / Q000503:physiopathology*; D009569:Nitric Oxide / Q000502:physiology*
D051242:Caveolin 1; D009569:Nitric Oxide