The effectiveness of warfarin dosing from a nomogram compared with house staff dosing.
The purpose of this study is to address the safety and efficacy of a warfarin dosing nomogram. Patients undergoing hip or knee arthroplasty were randomized to warfarin dosed by nomogram (n = 106) or by house staff (n = 110) during their hospital stay. The average daily dose of warfarin was 4.14 mg for the nomogram group and 4.18 mg for the house staff group. On postoperative day 4, the average international normalized ratio was 1.55 in the nomogram group compared with 1.59 in the house staff group. On postoperative day 4, 19.1% of the patients in the nomogram group had a therapeutic international normalized ratio, compared with 14.7% in the house staff group. There were no differences in bleeding or thrombotic complications in the 2 groups. This nomogram appears to be both safe and effective.
Asnis
Peter D
PD
Department of Orthopedic Surgery, Hospital for Special Surgery, New York, New York 10021, USA.
Gardner
Michael J
MJ
Ranawat
Anil
A
Leitzes
Anne H
AH
Peterson
Margaret G E
MG
Bass
Anne R
AR
D000368:Aged; D000925:Anticoagulants / Q000008:administration & dosage*; D019644:Arthroplasty, Replacement, Hip; D019645:Arthroplasty, Replacement, Knee; D005260:Female; D006801:Humans; D019934:International Normalized Ratio; D007396:Internship and Residency; D008297:Male; D011183:Postoperative Complications / Q000517:prevention & control*; D018709:Statistics, Nonparametric; D020246:Venous Thrombosis / Q000517:prevention & control*; D014859:Warfarin / Q000008:administration & dosage*
D000925:Anticoagulants; D014859:Warfarin