title: Derivation of rigorous conditions for high cell-type diversity by algebraic approach.
abstract: The development of a multicellular organism is a dynamic process. Starting with one or a few cells, the organism develops into different types of cells with distinct functions. We have constructed a simple model by considering the cell number increase and the cell-type order conservation, and have assessed conditions for cell-type diversity. This model is based on a stochastic Lindenmayer system with cell-to-cell interactions for three types of cells. In the present model, we have successfully derived complex but rigorous algebraic relations between the proliferation and transition rates for cell-type diversity by using a symbolic method: quantifier elimination (QE). Surprisingly, three modes for the proliferation and transition rates have emerged for large ratios of the initial cells to the developed cells. The three modes have revealed that the equality between the development rates for the highest cell-type diversity is reduced during the development process of multicellular organisms. Furthermore, we have found that the highest cell-type diversity originates from order conservation.
authors.affiliation: Laboratory of Biostatistics, Institute of Medical Science, The University of Tokyo, Shirokane-dai 4-6-1, Minato-ku, Tokyo 108-8639, Japan. phiroshi@math.kyushu-u.ac.jp
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yoshida
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Anai
authors.forename: Katsuhisa
authors.initials: K
authors.lastname: Horimoto
mesh_terms: D000465:Algorithms; D000818:Animals; D005075:Biological Evolution; D002449:Cell Aggregation; D002454:Cell Differentiation; D002455:Cell Division; D002468:Cell Physiological Phenomena; D049109:Cell Proliferation; D003198:Computer Simulation; D014644:Genetic Variation; D008954:Models, Biological; D015233:Models, Statistical; D008962:Models, Theoretical; D049490:Systems Biology