Coagulation factor XIII Val34Leu gene polymorphism and Alzheimer's disease.
Blood coagulation factor XIII (FXIII) plays a role in inflammatory processes and a pathogenetic role of inflammation in neurodegenerative disorders has been proposed. FXIIIa subunit was immunohistochemically detected in a subpopulation of reactive microglia in Alzheimer's disease (AD). Aim of the present study is to evaluate whether a common polymorphism of the FXIII gene is associated with sporadic AD. We examined 90 patients affected by sporadic AD and 139 age- and sex-matched controls to assess the distribution of V/L alleles and genotypes of the FXIIIa-subunit gene. The LL genotype showed a significantly higher frequency in AD patients (p<0.05) with a significantly increased risk of AD in the presence of LL genotype at the logistic regression analysis [odds ratio: 3.6 (1.36-9.44), p<0.01]. This study shows for the first time an association between FXIII Val34Leu polymorphism and AD.
Gerardino
L
L
Laboratory of Vascular Biology and Genetics, Department of Medicine, A. Gemelli University Hospital, L.go A. Gemelli 8, Rome 00168, Italy. gerlem@tin.it
Papaleo
P
P
Flex
A
A
Gaetani
E
E
Fioroni
G
G
Pola
P
P
Pola
R
R
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000235:genetics*; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D004252:DNA Mutational Analysis / Q000379:methods; D005176:Factor XIII / Q000235:genetics*; D005260:Female; D006801:Humans; D007930:Leucine / Q000235:genetics*; D016015:Logistic Models; D008297:Male; D011110:Polymorphism, Genetic; D014633:Valine / Q000235:genetics*
D005176:Factor XIII; D007930:Leucine; D014633:Valine