Extensive brown tumors caused by parathyroid adenoma in an adolescent patient.
Primary hyperparathyroidism is a rare endocrine disease in children and young adults. The early detection and treatment of primary hyperparathyroidism led to a marked decrease in classical bone and renal manifestations of the disease. Osteitis fibrosa cystica and brown tumors have become extremely rare clinical entities. Moreover, the skeletal involvement in primary hyperparathyroidism secondary to parathyroid adenoma is extremely rare. We report on an adolescent girl with multiple brown tumors and a history of recurrent fractures as the manifestation of primary hyperparathyroidism associated with a parathyroid adenoma. The patient's clinical presentation mimicked parathyroid carcinoma. She had a large tumor associated with marked elevation in the parathyroid hormone and serum calcium levels. Skeletal manifestations were also atypical for benign primary hyperparathyroidism, with widespread brown tumors in the patient.
Atabek
Mehmet Emre
ME
Department of Pediatrics, Division of Pediatric Endocrinology, Faculty of Medicine, Selcuk University, Konya, Turkey. meatabek@hotmail.com
Pirgon
Ozgur
O
Sert
Ahmet
A
Esen
H Hasan
HH
D000236:Adenoma / Q000150:complications* / Q000473:pathology / Q000601:surgery; D000293:Adolescent; D005260:Female; D006801:Humans; D049950:Hyperparathyroidism, Primary / Q000150:complications / Q000209:etiology* / Q000503:physiopathology; D010002:Osteitis Fibrosa Cystica / Q000209:etiology*; D010281:Parathyroid Hormone / Q000096:biosynthesis / Q000097:blood; D010282:Parathyroid Neoplasms / Q000150:complications* / Q000473:pathology / Q000601:surgery
D010281:Parathyroid Hormone