Imaging features of isolated unilateral pulmonary artery agenesis presenting in adulthood: a review of four cases.
OBJECTIVE
To highlight the variation in clinical manifestations, imaging and management of four cases of unilateral pulmonary artery agenesis presenting in adulthood.


METHODS
Four patients with unilateral pulmonary artery agenesis were referred to our institution between 1995 and 2005. They underwent a series of investigations, including chest radiography, echocardiography, ventilation perfusion scintigraphy, angiography, computed tomography (CT) and magnetic resonance imaging (MRI).


RESULTS
Two of the four patients had absence of the right main pulmonary artery, whilst the remaining two patients had absence of the left main pulmonary artery. One patient showed a restrictive defect on pulmonary function tests. Two patients who had ventilation perfusion scintigraphy showed absent perfusion and reduced ventilation on the affected side. Angiography (where performed), CT and MRI confirmed the anatomy and the presence of multiple collaterals. Bronchiectasis was demonstrated on CT in two patients, with one also demonstrating a mosaic attenuation pattern. One patient had an incidental lung tumour on the side of the agenesis, which was diagnosed as a chondroid hamartoma on histology. Three of the four patients eventually underwent resection of the affected lung.


CONCLUSIONS
Isolated unilateral pulmonary artery agenesis has a non-specific presentation. Awareness of this condition can lead to earlier diagnosis, with cross-sectional imaging making an important contribution.
Griffin
N
N
Royal Brompton and Harefield NHS Trust, London, UK. nyreegriffin@hotmail.com
Mansfield
L
L
Redmond
K C
KC
Dusmet
M
M
Goldstraw
P
P
Mittal
T K
TK
Padley
S
S
D000328:Adult; D000368:Aged; D001987:Bronchiectasis / Q000000981:diagnostic imaging / Q000209:etiology; D003097:Collateral Circulation; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000000981:diagnostic imaging / Q000209:etiology; D018810:Magnetic Resonance Angiography; D008297:Male; D011013:Pneumonectomy; D011651:Pulmonary Artery / Q000002:abnormalities* / Q000000981:diagnostic imaging* / Q000473:pathology; D012008:Recurrence; D012141:Respiratory Tract Infections / Q000209:etiology; D014057:Tomography, X-Ray Computed