title: Effects of low power red laser on induced-dental caries in rats.
abstract: OBJECTIVE
  The purpose of this study was to investigate the effects of low power red laser associated with acidulated phosphate fluoride on the development of induced-dental caries in rats.
  
  
  METHODS
  Dental caries were induced in molars of 40 rats divided into five groups: control group (CG), the teeth were not submitted to any treatment; laser group (LG), teeth were irradiated with a low power red laser (LPRL), power of 30 mW and dose of 5 J/cm(2); fluoride group (FG), teeth were treated with topical acidulated phosphate fluoride (APF) 1.23% applied for 4 min; laser+fluoride group (LFG), teeth were irradiated with LPRL followed by APF; fluoride+laser group (FLG), teeth were treated with APF followed by LPRL. The animals were killed after 48 days, and the first and second molars were extracted to analyze the caries lesion area, microhardness, and calcium and phosphorus ratio.
  
  
  RESULTS
  There were no statistical differences among FG, LFG, and FLG regarding to caries area and microhardness, although the caries area were smaller in LFG. Ca/P ratio did not show significant differences among all groups.
  
  
  CONCLUSIONS
  Although LPRL before APF application appeared to diminish the caries progression, LPRL did not present any additional benefit compared with acidulated phosphate fluoride on the prevention of induced-dental caries in rats.
authors.affiliation: Center for Lasers and Applications, IPEN-CNEN/SP, São Paulo, Brazil.
authors.forename: Karin P
authors.initials: KP
authors.lastname: Müller
authors.forename: Célia R M D
authors.initials: CR
authors.lastname: Rodrigues
authors.forename: Silvia C
authors.initials: SC
authors.lastname: Núñez
authors.forename: Raquel
authors.initials: R
authors.lastname: Rocha
authors.forename: Antonio O C
authors.initials: AO
authors.lastname: Jorge
authors.forename: Martha S
authors.initials: MS
authors.lastname: Ribeiro
mesh_terms: D000149:Acidulated Phosphate Fluoride / Q000008:administration & dosage / Q000627:therapeutic use; D000818:Animals; D002118:Calcium / Q000032:analysis; D002327:Cariostatic Agents / Q000008:administration & dosage / Q000627:therapeutic use; D003731:Dental Caries / Q000473:pathology / Q000517:prevention & control*; D018450:Disease Progression; D004577:Electron Probe Microanalysis; D005260:Female; D005459:Fluorides / Q000032:analysis; D006244:Hardness; D054023:Lasers, Semiconductor / Q000627:therapeutic use*; D028022:Low-Level Light Therapy; D008963:Molar / Q000187:drug effects / Q000528:radiation effects; D010758:Phosphorus / Q000032:analysis; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013053:Spectrophotometry
chemical_list: D002327:Cariostatic Agents; D010758:Phosphorus; D000149:Acidulated Phosphate Fluoride; D005459:Fluorides; D002118:Calcium