title: Interaction of methylmercury and selenium on the bioaccumulation and histopathology in medaka (Oryzias latipes).
abstract: Interaction of methylmercury and selenium in medaka (Oryzias latipes) on bioaccumulation of pollutants and histopathological changes in liver and gill were studied. Juvenile medaka fish were submitted to a series of waterborne methylmercury chloride (MMC), sodium selenite (Na(2)SeO(3)) and their mixture for 210 days, respectively. The methylmercury (MeHg) and selenium contents in the whole body of medaka were determined. The dose- and time-dependent increase of MeHg and selenium contents in medaka were observed. Histopathological changes, such as edema, vacuoles, pyknotic nucleus, and telangiectasis, could clearly be observed in the slices from the exposed medaka's liver and gill. Concurrent exposure to MMC and Na(2)SeO(3) showed the increased selenium accumulation. When the exposure molar ratio of MeHg:Se was about 1, the interaction between MeHg and selenium offered a limited protection against the serious intoxication of both MMC and Na(2)SeO(3) to medaka.
authors.affiliation: State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, P.O. Box 2871, Beijing 100085, China.
authors.forename: Chun-Yang
authors.initials: CY
authors.lastname: Liao
authors.forename: Qun-Fang
authors.initials: QF
authors.lastname: Zhou
authors.forename: Jian-Jie
authors.initials: JJ
authors.lastname: Fu
authors.forename: Jian-Bo
authors.initials: JB
authors.lastname: Shi
authors.forename: Chun-Gang
authors.initials: CG
authors.lastname: Yuan
authors.forename: Gui-Bin
authors.initials: GB
authors.lastname: Jiang
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D005880:Gills / Q000187:drug effects* / Q000473:pathology; D006651:Histocytochemistry; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D008767:Methylmercury Compounds / Q000378:metabolism / Q000633:toxicity*; D009990:Oryzias / Q000378:metabolism*; D018570:Risk Assessment; D012643:Selenium / Q000378:metabolism / Q000633:toxicity*; D018038:Sodium Selenite / Q000378:metabolism / Q000633:toxicity; D013997:Time Factors
chemical_list: D008767:Methylmercury Compounds; D012643:Selenium; D018038:Sodium Selenite; C004925:methylmercuric chloride