title: [Electrophysiological effects of acehytisine hydrochloride in a porcine model of acute coronary occlusion].
abstract: OBJECTIVE
  To observe the electrophysiological effect of Acehytisine Hydrochloride (AHH) in Wu Zhi Shan (WZS) micropigs with experimental acute coronary occlusion.
  
  
  METHODS
  Adult WZS micropigs were randomized into group A: coronary ligation with AHH infusion (n = 9); group B: AHH infusion without coronary ligation (n = 9) and group C: coronary ligation with saline (NS) infusion (n = 9). Surface ECGs and cardiac electrophysiological data including atrium, atrium-ventricle junction and ventricle electrograms were collected by programmed electrical stimulation at ischemic baseline and after AHH (or NS) infusion.
  
  
  RESULTS
  Compared to animals treated with AHH without ischemia, VARC-ERP was significantly increased while QT, QTc intervals, VRRP and VFRP were significantly reduced in ischemic animals treated with AHH. Compared to ischemic animals treated with saline, AHH prolongs the P-wave duration and PR interval, shortens QTc interval, prolongs ARP and AEP, also prolongs V-A reverse conduction time and VARC-ERP but shortens VFRP. No proarrhythmia effect was found in both AHH treated groups.
  
  
  CONCLUSIONS
  AHH resulted in significant electrophysiological effects on this porcine acute coronary ischemic model.
authors.affiliation: Emergency Division, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Liang
authors.forename: Jun
authors.initials: J
authors.lastname: Zhu
authors.forename: Yan-min
authors.initials: YM
authors.lastname: Yang
authors.forename: Jian-dong
authors.initials: JD
authors.lastname: Li
authors.forename: Yan
authors.initials: Y
authors.lastname: Sun
authors.forename: Jian
authors.initials: J
authors.lastname: Guan
authors.forename: Xin
authors.initials: X
authors.lastname: Gao
authors.forename: Chang-rui
authors.initials: CR
authors.lastname: Li
authors.forename: Yue
authors.initials: Y
authors.lastname: Tang
mesh_terms: D031841:Aconitum; D000818:Animals; D003327:Coronary Disease / Q000188:drug therapy / Q000503:physiopathology*; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D004594:Electrophysiology; D005260:Female; D008297:Male; D008517:Phytotherapy; D011897:Random Allocation; D013552:Swine; D013556:Swine, Miniature
chemical_list: D004365:Drugs, Chinese Herbal