title: Bacteremia in lung transplant recipients in the current era.
abstract: Current trends in the epidemiology, outcome and variables influencing mortality in bacteremic lung transplant recipients have not been fully described. We prospectively studied bacteremias in lung transplant recipients in a multicenter study between 2000-2004. Bacteremia was documented in 56 lung transplant recipients, an average of 172 days after transplantation. Multiple antibiotic resistance was documented in 48% of the isolates; these included 57% of the Gram-negative and 38% of the Gram-positive bacteria. Pulmonary infection was the most common source of resistant gram-negative bacteremias. Mortality rate at 28 days after the onset of bacteremia was 25% (14/56). Mechanical ventilation and abnormal mental status correlated independently with higher mortality (p < 0.05 for both variables). Bacteremia remains a significant complication in lung transplant recipients and is associated with considerable mortality. Recognition of variables portending a high risk for antibiotic resistance and for poor outcome has implications relevant for optimizing antibiotic prescription and for improving outcomes in lung transplant recipients.
authors.affiliation: Division of Infectious Diseases, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. husains@dom.pitt.edu
authors.forename: S
authors.initials: S
authors.lastname: Husain
authors.forename: K M
authors.initials: KM
authors.lastname: Chan
authors.forename: S M
authors.initials: SM
authors.lastname: Palmer
authors.forename: D
authors.initials: D
authors.lastname: Hadjiliadis
authors.forename: A
authors.initials: A
authors.lastname: Humar
authors.forename: K R
authors.initials: KR
authors.lastname: McCurry
authors.forename: M M
authors.initials: MM
authors.lastname: Wagener
authors.forename: N
authors.initials: N
authors.lastname: Singh
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D016470:Bacteremia / Q000188:drug therapy / Q000453:epidemiology*; D024881:Drug Resistance, Bacterial; D005260:Female; D006090:Gram-Negative Bacteria / Q000302:isolation & purification; D006094:Gram-Positive Bacteria / Q000302:isolation & purification; D006801:Humans; D016040:Lung Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000382:microbiology*; D011446:Prospective Studies
chemical_list: D000900:Anti-Bacterial Agents