Regional cerebral (18)FDG uptake during subarachnoid hemorrhage induced vasospasm.
OBJECTIVE
The aim was to elucidate whether aneurysmal subarachnoid hemorrhage (SAH)-induced vasospasm induces changes of regional glucose uptake in surgically treated, asymptomatic cases.


METHODS
(18)FDG uptake (standardized uptake value, SUV) was analysed with PET in eight surgically treated aneurismal patients with a mean middle cerebral artery flow velocity >120 cm/seconds measured with transcranial Doppler ultrasound. Data were compared with a healthy control group using Statistical Parametric Mapping (SPM99b).


RESULTS
Six of the eight patients had no focal neurological signs. The inhomogeneous bilateral increase in SUV (p<0.0001) was asymmetrical, with an almost 70% larger volume on the operated side. Reduced glucose uptake was found in the frontal and temporobasal regions of the two patients with neurological deficits (p<0.0001); the affected volume was 40% larger on the operated side.


CONCLUSIONS
SAH-induced vasospasm results in widespread increase of glucose uptake-probably reflecting increased glycolysis. This was earlier than neurological focal signs appear. Decreased glucose uptake can be detected in severe cases of vasospasm reflected by neurological deficit. Although the changes are more prominent where surgery had taken place our results suggest that not only the surgery, but also subarachnoid blood might have resulted in our findings.
Novak
Laszlo
L
Department of Neurosurgery, University of Debrecen, Health and Life Sciences Centre, Nagyerdei krt. 98., 4012 Debrecen, Hungary. lnovak@jaguar.dote.hu
Emri
Miklos
M
Molnar
Peter
P
Balkay
Laszlo
L
Szabo
Sandor
S
Rozsa
Laszlo
L
Lengyel
Zsolt
Z
Tron
Lajos
L
D000328:Adult; D001931:Brain Mapping; D003936:Diagnosis, Computer-Assisted; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography; D013345:Subarachnoid Hemorrhage / Q000150:complications; D020301:Vasospasm, Intracranial / Q000000981:diagnostic imaging* / Q000209:etiology
D019788:Fluorodeoxyglucose F18