PKA, germ cells, and fertility.
Temporal and spatial regulation of PKA activity are essential for vigorous sperm motility and for the resumption of meiosis in oocytes, two events required for successful fertilization. Genetic mutations in mice that affect PKA signaling in germ cells lead to infertility and illustrate the importance of this pathway in mammalian reproduction.
Burton
Kimberly A
KA
Department of Pharmacology, University of Washington, Seattle, WA, USA.
McKnight
G Stanley
GS
D000818:Animals; D017868:Cyclic AMP-Dependent Protein Kinases / Q000378:metabolism*; D005298:Fertility / Q000502:physiology*; D005854:Germ Cells / Q000166:cytology* / Q000201:enzymology*; D006801:Humans; D008540:Meiosis / Q000502:physiology; D009866:Oogenesis / Q000502:physiology; D013091:Spermatogenesis / Q000502:physiology
D017868:Cyclic AMP-Dependent Protein Kinases