title: Generalized pustular psoriasis and hepatic dysfunction associated with oral terbinafine therapy.
abstract: We report a case of 61-yr-old man with stable psoriasis who progressively developed generalized pustular eruption, erythroderma, fever, and hepatic dysfunction following oral terbinafine. Skin biopsy was compatible with pustular psoriasis. After discontinuation of terbinafine and initiating topical corticosteroid and calcipotriol combination with narrow band ultraviolet B therapy, patient's condition slowly improved until complete remission was reached 2 weeks later. The diagnosis of generalized pustular psoriasis (GPP) induced by oral terbinafine was made. To our knowledge, this is the first report of GPP accompanied by hepatic dysfunction associated with oral terbinafine therapy.
authors.affiliation: Department of Dermatology, Pusan National University College of Medicine, Busan, Korea, Korea.
authors.forename: Byung-Soo
authors.initials: BS
authors.lastname: Kim
authors.forename: Ho-Sun
authors.initials: HS
authors.lastname: Jang
authors.forename: Seung-Wook
authors.initials: SW
authors.lastname: Jwa
authors.forename: Bong-Seok
authors.initials: BS
authors.lastname: Jang
authors.forename: Moon-Bum
authors.initials: MB
authors.lastname: Kim
authors.forename: Chang-Keun
authors.initials: CK
authors.lastname: Oh
authors.forename: Yoo-Wook
authors.initials: YW
authors.lastname: Kwon
authors.forename: Kyung-Sool
authors.initials: KS
authors.lastname: Kwon
mesh_terms: D000284:Administration, Oral; D000935:Antifungal Agents / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury; D006801:Humans; D008297:Male; D008875:Middle Aged; D009281:Naphthalenes / Q000009:adverse effects*; D011565:Psoriasis / Q000139:chemically induced*; D013492:Suppuration / Q000139:chemically induced; D000077291:Terbinafine
chemical_list: D000935:Antifungal Agents; D009281:Naphthalenes; D000077291:Terbinafine