title: Decreased Lempel-Ziv complexity in Alzheimer's disease patients' magnetoencephalograms.
abstract: The aim of the present research is to study the magnetoencephalogram (MEG) background activity in patients with Alzheimer's disease (AD) using the Lempel-Ziv (LZ) complexity. We recorded the MEG with a 148-channel whole-head magnetometer (MAGNES 2500 WH, 4D Neuroimaging) in 10 patients with probable AD and 10 age-matched control subjects, during five minutes. Artefact-free epochs were selected for the non-linear analysis. In all MEG channels, the AD patients had lower complexity than control subjects. In 77 of them the differences were statistically significant (p < 0.01). These preliminary results suggest that cognitive dysfunction in AD is associated with a decreased complexity in certain regions of the brain.
authors.affiliation: E.T.S. Ingenieros de Telecomunicacion, Universidad de Valladolid, Spain. Email: cgompen@ribera.tel.uva.es.
authors.forename: Carlos
authors.initials: C
authors.lastname: Gomez
authors.forename: Roberto
authors.initials: R
authors.lastname: Hornero
authors.forename: Daniel
authors.initials: D
authors.lastname: Abasolo
authors.forename: Miguel
authors.initials: M
authors.lastname: Lopez
authors.forename: Alberto
authors.initials: A
authors.lastname: Fernandez