title: A new model for drug interactions and optimal drug dosing.
abstract: Drugs are routinely combined in anesthesia and pain management to obtain an enhancement of the desired effects. However, a parallel enhancement of the undesired effects might take place as well, resulting in a limited therapeutic usefulness. Therefore, when addressing the question of optimal drug combinations, side effects must be taken into account. We propose a new method to study drug interactions considering also their side effects and to identify optimal drug dosing. The model is consistent with clinical knowledge and can explain previously published experimental results, improving our understanding of the characteristics of drug combinations used in clinical practice.
authors.affiliation: Automatic Control Laboratory, Swiss Federal Institute of Technology (ETH), CH-8092 Zurich, Switzerland, zanderigo@control.ee.ethz.ch.
authors.forename: Eleonora
authors.initials: E
authors.lastname: Zanderigo
authors.forename: Valentina
authors.initials: V
authors.lastname: Sartori
authors.forename: Gorazd
authors.initials: G
authors.lastname: Sveticic
authors.forename: Thomas
authors.initials: T
authors.lastname: Bouillon
authors.forename: Peter
authors.initials: P
authors.lastname: Schumacher
authors.forename: Michele
authors.initials: M
authors.lastname: Curatolo
authors.forename: Manfred
authors.initials: M
authors.lastname: Morari