Myriaporones 1-4, cytotoxic metabolites from the Mediterranean bryozoan Myriapora truncata.
Four novel polyketide-derived metabolites, myriaporones 1, 2, 3, and 4, have been isolated from the Mediterranean bryozoan Myriapora truncata. Their structures and stereochemistry have been assigned from the analysis of spectroscopic data. The inseparable equilibrium mixture of myriaporones 3 and 4 showed 88% inhibition of L1210 murine leukemia cells at 0.2 microg/mL.
Cheng
Jie-Fei
JF
Roger Adams Laboratory, University of Illinois, Urbana, IL 61801, USA. jcheng@trlusa.com
Lee
Jong-Soo
JS
Sakai
Ryuichi
R
Jares-Erijman
Elizabeth A
EA
Silva
Maria V
MV
Rinehart
Kenneth L
KL
D000475:Alkenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002013:Bryozoa / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D004852:Epoxy Compounds / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D007939:Leukemia L1210; D008522:Mediterranean Sea; D051379:Mice; D015394:Molecular Structure; D011714:Pyrans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
D000475:Alkenes; D000970:Antineoplastic Agents; D004852:Epoxy Compounds; D011714:Pyrans; C476087:myriaporone 1; C505861:myriaporone 2; C505858:myriaporone 3; C505860:myriaporone 4