Correlation between serum ferritin levels and liver iron concentration determined by MR imaging: impact of hematologic disease and inflammation.
Liver iron concentration was determined in 28 patients by magnetic resonance imaging using the method of Gandon et al. (Non-invasive assessment of hepatic iron stores by MRI. Lancet 2004;363:357-362). The result showed a significant correlation with blood plasma ferritin content (Spearman's r=.66; P<.001) and a slightly improving correlation coefficient when limited to those patients not known to have inflammation (r=.82; n=17; P<.001). Zooming in on patients with hematologic disease also had a beneficial effect on the correlation between liver iron content and plasma ferritin level (r=.79; n=13; P=.001). It is concluded that in patients without inflammation and in patients with hematologic disease, the content of ferritin in blood is a better predictor of liver iron content than in other patient categories.
Olthof
Allard W
AW
Department of Radiology, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands. a.w.olthof@rad.umcg.nl
Sijens
Paul E
PE
Kreeftenberg
Herman G
HG
Kappert
Peter
P
Irwan
Roy
R
van der Jagt
Eric J
EJ
Oudkerk
Matthijs
M
D000465:Algorithms; D005260:Female; D005293:Ferritins / Q000097:blood*; D006801:Humans; D007501:Iron / Q000378:metabolism*; D008107:Liver Diseases / Q000378:metabolism*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged
D005293:Ferritins; D007501:Iron