title: Efficacy of a quadrivalent vaccine against respiratory diseases caused by BHV-1, PI3V, BVDV and BRSV in experimentally infected calves.
abstract: The efficacy of a quadrivalent vaccine against viral bovine respiratory diseases (BRD) was assessed in four experimental studies. Calves between 2 and 9 months of age were allocated to one of two treatment groups (n=9-15) and then received either the vaccine or sterile saline in two doses approximately 3 weeks apart. Three to 5 weeks after the second injection, animals were challenged experimentally with one of the viruses, bovine herpes-virus-1 (BHV-1), parainfluenza type-3 virus (PI(3)V), bovine viral-diarrhoea virus type 1 (BVDV), or bovine respiratory syncytial virus (BRSV) and were then monitored for at least 2 weeks. The administration of the vaccine was associated with enhanced antibody response to all four viruses post-challenge, with the reduction of the amount or duration (or both) of virus shedding in the BHV-1, PI(3)V, BVDV and BRSV studies and with an improvement of some clinical signs in the BHV-1 (nasal discharge, and rectal temperature) and the PI(3)V studies (abnormal respiration, and depression).
authors.affiliation: Veterinary Medicine Research and Development, Biologicals, Pfizer Animal Health Sandwich, CT13 9NJ, United Kingdom.
authors.forename: J S
authors.initials: JS
authors.lastname: Salt
authors.forename: S J
authors.initials: SJ
authors.lastname: Thevasagayam
authors.forename: A
authors.initials: A
authors.lastname: Wiseman
authors.forename: A R
authors.initials: AR
authors.lastname: Peters
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D001912:Bovine Virus Diarrhea-Mucosal Disease / Q000276:immunology / Q000517:prevention & control* / Q000821:virology; D002417:Cattle; D002418:Cattle Diseases / Q000276:immunology / Q000517:prevention & control* / Q000821:virology*; D001908:Diarrhea Viruses, Bovine Viral / Q000276:immunology; D006566:Herpesviridae Infections / Q000276:immunology / Q000517:prevention & control / Q000662:veterinary*; D007242:Herpesvirus 1, Bovine / Q000276:immunology; D029101:Parainfluenza Virus 3, Bovine / Q000276:immunology; D018357:Respiratory Syncytial Virus Infections / Q000276:immunology / Q000517:prevention & control / Q000662:veterinary*; D018112:Respiratory Syncytial Virus, Bovine / Q000276:immunology; D012141:Respiratory Tract Infections / Q000517:prevention & control / Q000662:veterinary* / Q000821:virology; D010253:Respirovirus Infections / Q000276:immunology / Q000517:prevention & control / Q000662:veterinary; D014765:Viral Vaccines / Q000276:immunology*; D014766:Viremia; D017201:Virus Shedding
chemical_list: D000914:Antibodies, Viral; D014765:Viral Vaccines