title: The effect of cinnamon extract on insulin resistance parameters in polycystic ovary syndrome: a pilot study.
abstract: Cinnamon extract has been shown to reduce insulin resistance in in vitro and in vivo studies by increasing phosphatidylinositol 3-kinase activity in the insulin signaling pathway and thus potentiating insulin action. Fifteen women with polycystic ovary syndrome (PCOS) were randomized to daily oral cinnamon and placebo for 8 weeks. Comparisons of post-treatment to baseline insulin sensitivity indices using fasting and 2-hour oral glucose tolerance tests showed significant reductions in insulin resistance in the cinnamon group but not in the placebo group. A larger trial is needed to confirm the findings of this pilot study and to evaluate the effect of cinnamon extract on menstrual cyclicity.
authors.affiliation: Department of Obstetrics & Gynecology, Division of Reproductive Endocrinology, College of Physicians & Surgeons, Columbia University, New York, New York 10023, USA. jw781@columbia.edu
authors.forename: Jeff G
authors.initials: JG
authors.lastname: Wang
authors.forename: Richard A
authors.initials: RA
authors.lastname: Anderson
authors.forename: George M
authors.initials: GM
authors.lastname: Graham
authors.forename: Micheline C
authors.initials: MC
authors.lastname: Chu
authors.forename: Mark V
authors.initials: MV
authors.lastname: Sauer
authors.forename: Michael M
authors.initials: MM
authors.lastname: Guarnaccia
authors.forename: Rogerio A
authors.initials: RA
authors.lastname: Lobo
mesh_terms: D000328:Adult; D002935:Cinnamomum zeylanicum; D005260:Female; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D010865:Pilot Projects; D010936:Plant Extracts / Q000627:therapeutic use; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000188:drug therapy*
chemical_list: D010936:Plant Extracts