title: Preoperative nutritional status predicts the severity of the systemic inflammatory response syndrome (SIRS) following major vascular surgery.
abstract: OBJECTIVE
  This study examined the relationship between pre-operative nutritional status and systemic inflammatory response syndrome (SIRS) or sepsis following major vascular surgery.
  
  
  METHODS
  Subjects undergoing open AAA repair, EVAR or lower limb revascularisation were studied prospectively. Pre-operative nutrition was assessed clinically using Mini-Nutritional Assessment (MNA) and body composition was measured by dual energy X-ray absorptiometry (DEXA) scanning. SIRS severity was assessed for 5 post-operative days and sepsis noted within 30 days of surgery.
  
  
  RESULTS
  Using MNA, neither SIRS severity nor sepsis occurrence differed significantly between 'well-nourished' subjects and those 'at risk of malnutrition'. Using DEXA, negative associations existed between body mass index and both SIRS score and SIRS duration. Fat free mass (FFM) was negatively associated with SIRS score and duration. Negative associations also existed between skeletal muscle mass (SMM) and SIRS score and duration. SMM was also negatively correlated with post-operative length of stay in hospital. There were no significant correlations between sepsis and any nutritional indices.
  
  
  CONCLUSIONS
  Lower pre-operative nutritional indices, indicating protein energy malnutrition, were associated with more severe systemic inflammatory responses following major vascular surgery.
authors.affiliation: Discipline of Surgery, School of Medicine, The University of Adelaide, The Queen Elizabeth Hospital, Woodville, South Australia, Australia.
authors.forename: T A
authors.initials: TA
authors.lastname: Hassen
authors.forename: S
authors.initials: S
authors.lastname: Pearson
authors.forename: P A
authors.initials: PA
authors.lastname: Cowled
authors.forename: R A
authors.initials: RA
authors.lastname: Fitridge
mesh_terms: D015502:Absorptiometry, Photon; D000368:Aged; D017544:Aortic Aneurysm, Abdominal / Q000601:surgery; D015992:Body Mass Index; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D007511:Ischemia / Q000601:surgery; D007866:Leg / Q000098:blood supply; D008297:Male; D008875:Middle Aged; D009752:Nutritional Status; D011183:Postoperative Complications; D011379:Prognosis; D011446:Prospective Studies; D012720:Severity of Illness Index; D013021:South Australia / Q000453:epidemiology; D018746:Systemic Inflammatory Response Syndrome / Q000175:diagnosis / Q000453:epidemiology / Q000517:prevention & control; D013648:Tasmania / Q000453:epidemiology; D014656:Vascular Surgical Procedures / Q000009:adverse effects*