title: Methylprednisolone administration alters adenine nucleotide hydrolysis in rat blood serum.
abstract: The effect of methylprednisolone on the hydrolysis of adenine nucleotides by rat blood serum enzymes was studied. Adult male Wistar rats were submitted to three different treatments with synthetic steroid methylprednisolone: one dose of 50 mg/kg, i.p. (acute); or oral doses of 6 mg/kg dissolved in drinking water for 15 (sub-chronic) or 30 (chronic) days. Decreased ADP hydrolysis was observed after acute and sub-chronic treatments. Furthermore, ATP, ADP and AMP hydrolysis decreased after chronic treatment. These alterations may constitute one of the mechanisms that mediate the development of some of the side effects associated with corticosteroid use.
authors.affiliation: Departamentos de Farmacologia, Instituto de Ciências Básicas da Saúde, UFRGS, Rua Sarmiento Leite 500, 90050-170 Porto Alegre, RS, Brazil. iracitorres@gmail.com
authors.forename: Iraci Lucena S
authors.initials: IL
authors.lastname: Torres
authors.forename: Cristina Ribas
authors.initials: CR
authors.lastname: Fürstenau
authors.forename: Gabriela
authors.initials: G
authors.lastname: Rossi
authors.forename: Eliane
authors.initials: E
authors.lastname: Dallegrave
authors.forename: Gustavo
authors.initials: G
authors.lastname: Dallegrave
authors.forename: Barbara
authors.initials: B
authors.lastname: Stenzel
authors.forename: Giovana
authors.initials: G
authors.lastname: Dantas
authors.forename: Ana Maria O
authors.initials: AM
authors.lastname: Battastini
authors.forename: João J F
authors.initials: JJ
authors.lastname: Sarkis
authors.forename: Maria Beatriz C
authors.initials: MB
authors.lastname: Ferreira
mesh_terms: D000227:Adenine Nucleotides / Q000097:blood*; D000375:Aging / Q000378:metabolism; D000818:Animals; D006868:Hydrolysis; D008297:Male; D008775:Methylprednisolone / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000227:Adenine Nucleotides; D008775:Methylprednisolone