title: Age estimates of ancestral mutations causing factor VII deficiency and Dubin-Johnson syndrome in Iranian and Moroccan Jews are consistent with ancient Jewish migrations.
abstract: Factor VII (FVII) deficiency and Dubin-Johnson syndrome (DJS) are rare autosomal recessive disorders caused by mutations in F7 and MRP2 genes, respectively. Both disorders are relatively frequent among Iranian and Moroccan Jews. FVII deficiency in both populations is caused by a founder A244V mutation in the F7 gene and DJS is caused by two founder mutations, I1173F and R1150H in the MRP2 gene that are specific for Iranian and Moroccan Jewish patients, respectively. We estimated the age of FVII A244V and MRP2 I1173F by analysis of microsatellite markers flanking F7 and MRP2 genes, respectively, in 13 Iranian Jewish homozygotes for the I1173F mutation and 21 Iranian and Moroccan Jewish homozygotes for the A244V mutation. Dating of the mutations was estimated by the DMLE+2.0 program employing observed linkage disequilibria of multiple genetic markers. The estimated age of the I1173F mutation was approximately 1500 years, and the age of the A244V mutation was approximately 2600 years. These estimates suggest that I1173F causing DJS in Iranian Jews occurred after the separation of Iranian Jews from Moroccan Jews 2000-2600 years ago, while A244V causing FVII deficiency in Iranian and Moroccan Jews occurred prior to the divergence of these two populations.
authors.affiliation: The Amalia Biron Research Institute of Thrombosis and Hemostasis, Chaim Sheba Medical Center, Tel Hashomer and Sackler School of Medicine, Tel Aviv University, Tel-Aviv, Israel.
authors.forename: Ronit
authors.initials: R
authors.lastname: Mor-Cohen
authors.forename: Ariella
authors.initials: A
authors.lastname: Zivelin
authors.forename: Yonit
authors.initials: Y
authors.lastname: Fromovich-Amit
authors.forename: Victoria
authors.initials: V
authors.lastname: Kovalski
authors.forename: Nurit
authors.initials: N
authors.lastname: Rosenberg
authors.forename: Uri
authors.initials: U
authors.lastname: Seligsohn
mesh_terms: D004641:Emigration and Immigration; D005167:Factor VII / Q000235:genetics; D005168:Factor VII Deficiency / Q000208:ethnology* / Q000235:genetics* / Q000266:history; D018703:Founder Effect; D049690:History, Ancient; D006801:Humans; D007492:Iran / Q000453:epidemiology / Q000208:ethnology; D007566:Jaundice, Chronic Idiopathic / Q000208:ethnology* / Q000235:genetics* / Q000266:history; D007585:Jews / Q000235:genetics*; D015810:Linkage Disequilibrium; D026901:Membrane Transport Proteins / Q000235:genetics; D018895:Microsatellite Repeats; D009018:Morocco / Q000453:epidemiology / Q000208:ethnology; D000089762:Multidrug Resistance-Associated Protein 2; D027425:ATP-Binding Cassette, Sub-Family C Proteins / Q000235:genetics; D009154:Mutation; D020125:Mutation, Missense; D013995:Time
chemical_list: D005167:Factor VII; D026901:Membrane Transport Proteins; D000089762:Multidrug Resistance-Associated Protein 2; D027425:ATP-Binding Cassette, Sub-Family C Proteins; C000715087:ABCC2 protein, human