title: Interleukin 7 requirement for survival of T-cell acute lymphoblastic leukemia and human thymocytes on bone marrow stroma.
abstract: We explored the role of interleukin-7 (IL-7) in the bone marrow (BM) stroma-mediated survival of primary T-cell acute lymphoblastic leukemia (T-ALL) cells and normal thymocytes. We presented evidence that IL-7 has a major role in the enhanced survival mediated by BM stroma both in T-ALL cells and thymocytes.
authors.forename: Maria T
authors.initials: MT
authors.lastname: Scupoli
authors.forename: Omar
authors.initials: O
authors.lastname: Perbellini
authors.forename: Mauro
authors.initials: M
authors.lastname: Krampera
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Vinante
authors.forename: Federica
authors.initials: F
authors.lastname: Cioffi
authors.forename: Giovanni
authors.initials: G
authors.lastname: Pizzolo
mesh_terms: D000818:Animals; D001854:Bone Marrow Cells / Q000166:cytology*; D049109:Cell Proliferation; D002470:Cell Survival; D002648:Child; D002675:Child, Preschool; D018920:Coculture Techniques; D005434:Flow Cytometry; D006801:Humans; D007223:Infant; D015851:Interleukin-7 / Q000096:biosynthesis / Q000502:physiology*; D038041:Lymphopoiesis; D051379:Mice; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000097:blood*; D013950:Thymus Gland / Q000166:cytology* / Q000378:metabolism
chemical_list: D015851:Interleukin-7