Biomedical modification of poly(L-lactide) by blending with lecithin.
Lecithin was, for the first time, blended with PLLA to prepare scaffold material for tissue engineering applications in the present study. Solution blending was used to incorporate Lecithin (containing 0-10 wt %) with PLLA to enhance the blend films biocompatibility, hydrophilicity and toughness while maintaining mechanical strength of PLLA. The results of FTIR-ATR analysis indicated that the amino groups of lecitin existed in the films. DSC analysis indicated that T(g) decreased with the increase of lecithin content in the blend films. The percentage elongation markedly increased with increase of lecithin content. The proliferation and viability of the vascular smooth muscle cell cultures on PLLA/Lecithin (containing 3-7 wt %) films were significantly enhanced compared to pure PLLA on tissue culture plates.
Zhu
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N
Laboratory of Advanced Materials, Department of Materials Science and Engineering, Tsinghua University, Beijing 100084, People's Republic of China.
Cui
F Z
FZ
Hu
K
K
Zhu
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L
D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry; D001696:Biomechanical Phenomena; D002152:Calorimetry, Differential Scanning; D002448:Cell Adhesion; D049109:Cell Proliferation; D002478:Cells, Cultured; D008422:Materials Testing; D032389:Myocytes, Smooth Muscle / Q000166:cytology; D010713:Phosphatidylcholines / Q000737:chemistry; D011091:Polyesters / Q000737:chemistry; D051381:Rats; D017550:Spectroscopy, Fourier Transform Infrared; D013816:Thermodynamics; D023822:Tissue Engineering
D001672:Biocompatible Materials; D010713:Phosphatidylcholines; D011091:Polyesters; C033616:poly(lactide)