Clinical outcome following stimulation with HMG versus highly purified HMG in patients undergoing ICSI.
Current purification processes allow the production of highly purified human menopausal gonadotrophin (HP-HMG), with human chorionic gonadotrophin (HCG) constituting most of its LH-like activity. This retrospective study aimed to compare the effectiveness of HP-HMG to the widely used traditional human menopausal gonadotrophin (HMG) preparation. A total of 174 women undergoing intracytoplasmic sperm injection cycles were allocated to either HMG or HP-HMG for ovarian stimulation. The number of mature oocytes was significantly higher in the HP-HMG group (14.72 +/- 7.81) than in the HMG group (12.15 +/- 11.07) (P < 0.05). However, the number of good quality embryos was not significantly different between both groups (HMG: 1.65 +/- 1.54; HP-HMG: 1.78 +/- 1.41). Similarly, there was no statistically significant difference in number of embryos transferred per woman (HMG: 3.95 +/- 1.87; HP-HMG: 4.27 +/- 1.60). The pregnancy rate per woman was 38.39% versus 51.79% in the HMG- and HP-HMG-treated groups respectively. These findings suggest that HP-HMG produces more mature oocytes than ordinary HMG, but similar pregnancy rates.
Foutouh
Ismail Aboul
IA
Department of Obstetrics and Gynecology, Cairo University, Cairo, Egypt. kaainih@link.net
Khattab
Sherif
S
Mohesn
Iman Abdel
IA
Moaz
Mohamed
M
Al-Inany
Hesham
H
D000328:Adult; D005260:Female; D005300:Fertility Agents, Female / Q000302:isolation & purification*; D006801:Humans; D008596:Menotropins / Q000302:isolation & purification*; D010062:Ovulation Induction / Q000379:methods* / Q000706:statistics & numerical data; D011247:Pregnancy; D012189:Retrospective Studies; D020554:Sperm Injections, Intracytoplasmic; D016896:Treatment Outcome
D005300:Fertility Agents, Female; D008596:Menotropins