Exploratory activity, motor coordination, and spatial learning in Mchr1 knockout mice.
Male mice with a null mutation of Mchr1, encoding melanin concentrating hormone receptor-1, were compared to wild-type on two background strains. Mchr1 knockout (KO) mice were more active than 129/SvEv and C57BL/6J wild-type strains in a photocell actimeter. In addition, Mchr1 KO mice on the C57BL/6J background were less anxious in the elevated plus-maze, while on the 129/SvEv background, the mutants were less emotionally reactive as estimated by fecal boli and handling-related vocalization. There was no detrimental impact of the null mutation on motor coordination and spatial learning. Mchr1 KO mice had shorter latencies before reaching the escape platform, but only on the 129/SvEv background. Null mutants were lighter than C57BL/6J controls but heavier than 129/SvEv controls, attributable to interactions with strain-dependent genes.
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Université de Rouen, Faculté de Médecine et de Pharmacie, 22 bld Gambetta, Bâtiment de Recherche, INSERM U614, IFRMP, 76183 Rouen Cedex, France. robert.lalonde@univ-rouen.fr
Qian
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D000704:Analysis of Variance; D000818:Animals; D001007:Anxiety / Q000235:genetics / Q000378:metabolism*; D005106:Exploratory Behavior / Q000502:physiology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D009043:Motor Activity / Q000502:physiology*; D017481:Receptors, Somatostatin / Q000235:genetics / Q000378:metabolism*; D045442:Rotarod Performance Test; D013045:Species Specificity; D018709:Statistics, Nonparametric
C491209:Mchr1 protein, mouse; D017481:Receptors, Somatostatin