Hydrophobic grafted and cross-linked starch nanoparticles for drug delivery.
The synthesis of modified hydrophobic starch nanoparticles using long chain fatty acids was accomplished. Grafting of fatty acid on the starch was done using potassium persulphate as catalyst and the formation of graft polymer was confirmed by FTIR spectra. The thermal properties of the native and grafted starch were investigated using simultaneous TG-DTA and DSC. The graft polymerization was found to be depending on the temperature and the duration of the reaction. The modified starch nanoparticles were cross-linked with sodium tripoly phosphate for better stabilization. Morphology of the grafted starch nanoparticles was studied by SEM and AFM. Drug-loading and the controlled release of the drug from the nanoparticles was studied using indomethacin as model drug.
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Chemical Sciences and Technology Division, Regional Research Laboratory (CSIR), Thiruvananthapuram, India. emiliatea@yahoo.com
Emilia Abraham
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D003432:Cross-Linking Reagents; D016503:Drug Delivery Systems; D057927:Hydrophobic and Hydrophilic Interactions; D066298:In Vitro Techniques; D018625:Microscopy, Atomic Force; D008855:Microscopy, Electron, Scanning; D015394:Molecular Structure; D053758:Nanoparticles / Q000737:chemistry; D036103:Nanotechnology; D019301:Oleic Acid / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared; D013213:Starch / Q000737:chemistry*; D013229:Stearic Acids / Q000737:chemistry
D003432:Cross-Linking Reagents; D013229:Stearic Acids; D019301:Oleic Acid; C031183:stearic acid; D013213:Starch