title: High-resolution solid-state manometry of the antropyloroduodenal region.
abstract: Manometric recording from the pyloric channel is challenging and is usually performed with a sleeve device. Recently, a solid-state manometry system was developed, which incorporates 36 circumferential pressure sensors spaced at 1-cm intervals. Our aim was to use this system to determine whether it provided useful manometric measurements of the pyloric region. We recruited 10 healthy subjects (7 males:3 females). The catheter (ManoScan(360)) was introduced transnasally and, in the final position, 15-20 sensors were in the stomach and the remainder distributed across the pylorus and duodenum. Patients were recorded fasting and then given a meal and recorded postprandially. Using pressure data and isocontour plots, the pylorus was identified in all subjects. Mean pyloric width was 2.1 +/- 0.1 cm (95% CI: 1.40-2.40). Basal pyloric pressure during phase I was 9.4 +/- 1.1 mmHg, while basal antral pressure was significantly lower (P = 0.003; 95% CI: 2.4-8.4). Pyloric pressure was always elevated relative to antral pressure in phase I. For phases II and III, pyloric pressure was 7.7 +/- 2.3 mmHg and 9.4 +/- 1.1 mmHg, respectively. Pyloric pressure increased similarly after both the liquid and solid meal. In addition, isolated pressure events and waves, which involve the pylorus, were readily identified.
authors.affiliation: Department of Medicine, Section of Gastroenterology, Temple University School of Medicine, Philadelphia, PA 19140, USA.
authors.forename: J
authors.initials: J
authors.lastname: Desipio
authors.forename: F K
authors.initials: FK
authors.lastname: Friedenberg
authors.forename: A
authors.initials: A
authors.lastname: Korimilli
authors.forename: J E
authors.initials: JE
authors.lastname: Richter
authors.forename: H P
authors.initials: HP
authors.lastname: Parkman
authors.forename: R S
authors.initials: RS
authors.lastname: Fisher
mesh_terms: D002404:Catheterization; D004386:Duodenum / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008365:Manometry / Q000295:instrumentation* / Q000379:methods*; D011706:Pyloric Antrum / Q000502:physiology*