title: Matrix metalloproteinase expression and localization in turkey (Meleagris gallopavo) during the endochondral ossification process.
abstract: Vertebrate long bones are formed by endochondral ossification, a process accompanied by changes in extracellular matrix synthesis and remodeling, performed mainly by the matrix metalloproteinases (MMP). The temporal/spatial expression patterns of 5 members of the MMP family known to be important for endochondral ossification were studied, for the first time, in the turkey growth plate during embryonic and juvenile stages. The expression of MMP-2 was detected in the proliferative zone, MMP-3, MMP-9, and MMP-13 in cells lining the blood vessels; MMP-13 was also detected in hypertrophic chondrocytes. The MMP-16 expression was detected in the reserve zone of the growth plate. These results present a detailed survey of turkey MMP, serving as a data source (atlas) for further studies in this subject.
authors.affiliation: Department of Biochemistry and Nutrition, Faculty of Agricultural, Food and Environmental Quality Sciences, The Hebrew University, Rehovot, Israel.
authors.forename: S
authors.initials: S
authors.lastname: Simsa
authors.forename: O
authors.initials: O
authors.lastname: Genina
authors.forename: E Monsonego
authors.initials: EM
authors.lastname: Ornan
mesh_terms: D000818:Animals; D018507:Gene Expression Regulation, Developmental; D015971:Gene Expression Regulation, Enzymologic; D006132:Growth Plate / Q000201:enzymology; D006614:Hindlimb; D020782:Matrix Metalloproteinases / Q000378:metabolism*; D010012:Osteogenesis / Q000502:physiology*; D021381:Protein Transport; D014422:Turkeys / Q000196:embryology / Q000254:growth & development* / Q000378:metabolism*
chemical_list: D020782:Matrix Metalloproteinases