Structure of rat acidic fibroblast growth factor at 1.4 A resolution.
Fibroblast growth factors (FGFs) constitute a family of 22 structurally related heparin-binding polypeptides that are involved in the regulation of cell growth, survival, differentiation and migration. Here, a 1.4 A resolution X-ray structure of rat FGF1 is presented. Two molecules are present in the asymmetric unit of the crystal and they coordinate a total of five sulfate ions. The structures of human, bovine and newt FGF1 have been published previously. Human and rat FGF1 are found to have very similar structures.
Kulahin
Nikolaj
N
Protein Laboratory, Institute of Molecular Pathology, Panum Institute, Blegdamsvej 3C, DK-2200 Copenhagen, Denmark. kulahin@plab.ku.dk
Kiselyov
Vladislav
V
Kochoyan
Arthur
A
Kristensen
Ole
O
Kastrup
Jette Sandholm
JS
Berezin
Vladimir
V
Bock
Elisabeth
E
Gajhede
Michael
M
D000818:Animals; D002417:Cattle; D018360:Crystallography, X-Ray; D016220:Fibroblast Growth Factor 1 / Q000737:chemistry*; D006801:Humans; D008958:Models, Molecular; D011487:Protein Conformation; D051381:Rats; D013045:Species Specificity
D016220:Fibroblast Growth Factor 1