title: Trypanosoma cruzi (kinetoplastida Trypanosomatidae): biological heterogeneity in the isolates derived from wild hosts.
abstract: The course of experimental infection of Swiss mice with 95 sylvatic Trypanosoma cruzi isolates included in TCI or TCII genotype was characterized. The purpose was to verify biological properties and its eventual correspondence with original host species, genotype or zymodeme. The isolates of T. cruzi were 100% infective, 55% resulted in patent parasitemia with 69% (36/52) of mortality. A meaningful biological heterogeneity was observed in both, TCI and TCII isolates. TCII isolates resulted in higher patent parasitemia 64% (38/59), in contrast to the 41% TCI infected Swiss mice (14/34). Parasitemia was not always associated to mortality. Higher biological heterogeneity was observed in T. cruzi II isolates derived from L. rosalia from the Atlantic Coastal Rain forest. TCII isolates derived from marsupials resulted in very similar infection profile in Swiss mice.
authors.affiliation: Departamento de Protozoologia, Laboratório de Biologia de Tripanosomatídeos, Instituto Oswaldo Cruz, Fiocruz, Av. Brasil 4365, 21040-900, Rio de Janeiro, Brazil.
authors.forename: Cristiane Varella
authors.initials: CV
authors.lastname: Lisboa
authors.forename: Ana Paula
authors.initials: AP
authors.lastname: Pinho
authors.forename: Rafael Veríssimo
authors.initials: RV
authors.lastname: Monteiro
authors.forename: Ana Maria
authors.initials: AM
authors.lastname: Jansen
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D000835:Animals, Wild; D014355:Chagas Disease / Q000469:parasitology / Q000662:veterinary*; D005838:Genotype; D007303:Insect Vectors / Q000469:parasitology*; D007527:Isoenzymes / Q000032:analysis / Q000235:genetics; D008394:Marsupialia; D051379:Mice; D018512:Parasitemia / Q000469:parasitology / Q000662:veterinary; D018419:Primate Diseases / Q000469:parasitology*; D011323:Primates; D012376:Rodent Diseases / Q000469:parasitology*; D012377:Rodentia; D014225:Triatominae / Q000469:parasitology; D014349:Trypanosoma cruzi / Q000145:classification* / Q000201:enzymology / Q000235:genetics
chemical_list: D007527:Isoenzymes