title: Physiologically-based minimal model of agitation-sedation dynamics.
abstract: Agitation-sedation cycling in critically ill patients, characterized by oscillations between states of agitation and over-sedation, damages patient health and increases length of stay and cost. The model presented captures the essential dynamics of the agitation-sedation system, is physiologically representative, and is validated by accurately simulating patient response for 37 critical care patients. The model provides a platform to develop and test controllers that offer the potential of improved agitation management.
authors.affiliation: Dept. of Mechanical Eng., Canterbury Univ., Christchurch, New Zealand.
authors.forename: A D
authors.initials: AD
authors.lastname: Rudge
authors.forename: J G
authors.initials: JG
authors.lastname: Chase
authors.forename: G M
authors.initials: GM
authors.lastname: Shaw
authors.forename: D
authors.initials: D
authors.lastname: Lee