title: Nonlinear analysis in treatment of intractable epilepsy with EEG biofeedback.
abstract: About 25% epilepsy patients are suffering from medically intractable epileptic seizure. Many studies have shown that electroencephalogram (EEG) biofeedback therapy has the exciting potential for seizure control. In this paper, five patients with intractable epilepsy were trained to increase the production of sensorimotor (12~15Hz) activity and decrease the production of slow theta (4~7Hz) activity. Nonlinear analysis are proposed to evaluate the effect of biofeedback training. In all the five patients, the complexity and approximate entropy of EEG increased significantly (P<0.05) after (about 1-month) the biofeedback treatment.
authors.affiliation: Department of Biomedical Engineering, Tsinghua University, Beijing 100084, China.
authors.forename: Longlian
authors.initials: L
authors.lastname: Zhao
authors.forename: Zuoqing
authors.initials: Z
authors.lastname: Liang
authors.forename: Guangshu
authors.initials: G
authors.lastname: Hu
authors.forename: Wenqing
authors.initials: W
authors.lastname: Wu