Organocatalytic cascade reactions based on push-pull dienamine platform: synthesis of highly substituted anilines.
A practical and novel one-pot organocatalytic selective process for the cascade synthesis of highly substituted o-hydroxydiarylamines and o-pyrrolidin-1-yldiarylamines is reported. Direct combination of amine-catalyzed cascade Knoevenagel/Michael/aldol condensation/decarboxylation and cascade enamine amination/isoaromatization of alkyl acetoacetates, aldehydes, and nitrosoarenes furnished the highly functionalized anilines with high yields.
Ramachary
Dhevalapally B
DB
School of Chemistry, University of Hyderabad, Central University (PO), Hyderabad 500 046, India. ramsc@uohyd.ernet.in
Ramakumar
Kinthada
K
Narayana
Vidadala V
VV