Physiological and pharmacological functions of Mrp2, Mrp3 and Mrp4 as determined from recent studies on gene-disrupted mice.
The MRP family is composed of nine transporters, at least eight of which are lipophilic anion transporters that are capable of conferring resistance to various anticancer agents. Recently, mice with gene disruptions in Mrp2, Mrp3 and Mrp4 have been developed. This review will discuss insights into the physiological and pharmacological functions of Mrp2, Mrp3 and Mrp4 afforded by investigations of these new mouse models.
Kruh
Gary D
GD
Medical Science Division, Fox Chase Cancer Center, Philadelphia, PA 19111, USA. GD_Kruh@fccc.edu
Belinsky
Martin G
MG
Gallo
James M
JM
Lee
Kun
K
D000818:Animals; D019742:Chemokines, CC; D019008:Drug Resistance, Neoplasm / Q000235:genetics; D019402:Macrophage Inflammatory Proteins / Q000235:genetics / Q000502:physiology*; D051379:Mice; D018345:Mice, Knockout; D027425:ATP-Binding Cassette, Sub-Family C Proteins / Q000235:genetics / Q000502:physiology*
D019742:Chemokines, CC; D019402:Macrophage Inflammatory Proteins; D027425:ATP-Binding Cassette, Sub-Family C Proteins; C489540:Abcc4 protein, mouse; C095218:Ccl9 protein, mouse; C114462:multidrug resistance-associated protein 3