Generalized pustular psoriasis and hepatic dysfunction associated with oral terbinafine therapy.
We report a case of 61-yr-old man with stable psoriasis who progressively developed generalized pustular eruption, erythroderma, fever, and hepatic dysfunction following oral terbinafine. Skin biopsy was compatible with pustular psoriasis. After discontinuation of terbinafine and initiating topical corticosteroid and calcipotriol combination with narrow band ultraviolet B therapy, patient's condition slowly improved until complete remission was reached 2 weeks later. The diagnosis of generalized pustular psoriasis (GPP) induced by oral terbinafine was made. To our knowledge, this is the first report of GPP accompanied by hepatic dysfunction associated with oral terbinafine therapy.
Kim
Byung-Soo
BS
Department of Dermatology, Pusan National University College of Medicine, Busan, Korea, Korea.
Jang
Ho-Sun
HS
Jwa
Seung-Wook
SW
Jang
Bong-Seok
BS
Kim
Moon-Bum
MB
Oh
Chang-Keun
CK
Kwon
Yoo-Wook
YW
Kwon
Kyung-Sool
KS
D000284:Administration, Oral; D000935:Antifungal Agents / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury; D006801:Humans; D008297:Male; D008875:Middle Aged; D009281:Naphthalenes / Q000009:adverse effects*; D011565:Psoriasis / Q000139:chemically induced*; D013492:Suppuration / Q000139:chemically induced; D000077291:Terbinafine
D000935:Antifungal Agents; D009281:Naphthalenes; D000077291:Terbinafine