title: Successful combination therapy of a proximal haemophilic pseudotumour with surgery, radiation and embolization in a child with mild haemophilia A.
abstract: We describe the management of a young boy with mild haemophilia A and a massive iliac pseudotumour with a multi modality approach involving factor replacement, radiation therapy, embolization and surgery. The patient was initially treated with recombinant factor VIII and radiation therapy. Because of inadequate response and worsening of bony erosion, the patient had a preoperative embolization followed by surgical excision. The surgical procedure was associated with minimal blood loss and the patient had a relatively smooth postoperative course with no physical morbidity. This case illustrates successful aggressive management of a large, proximally located pelvic pseudotumour, which resulted in an excellent outcome despite the need for a normally morbid operation.
authors.affiliation: Department of Pediatrics, University of Louisville, Louisville, KY 40202, USA. s0ahuj01@louisville.edu
authors.forename: S P
authors.initials: SP
authors.lastname: Ahuja
authors.forename: R
authors.initials: R
authors.lastname: Sidonio
authors.forename: A B
authors.initials: AB
authors.lastname: Raj
authors.forename: S J
authors.initials: SJ
authors.lastname: Bertolone
authors.forename: C
authors.initials: C
authors.lastname: Silverman
authors.forename: D P
authors.initials: DP
authors.lastname: Antekeier
authors.forename: M E
authors.initials: ME
authors.lastname: Fallat
mesh_terms: D000293:Adolescent; D001847:Bone Diseases / Q000628:therapy*; D003131:Combined Modality Therapy / Q000379:methods; D004621:Embolization, Therapeutic / Q000379:methods; D005169:Factor VIII / Q000627:therapeutic use; D006104:Granuloma, Plasma Cell / Q000628:therapy*; D006467:Hemophilia A / Q000150:complications*; D006801:Humans; D007085:Ilium; D008297:Male; D014057:Tomography, X-Ray Computed
chemical_list: D005169:Factor VIII