title: Halothane induced fulminant hepatic failure.
abstract: A rare case of halothane-induced fulminant hepatic failure is reported in a 22 years old male, who developed fever, jaundice, coma and deranged coagulation profile, 2 days after undergoing laparotomy under halothane anaesthesia. Despite all supportive care, he died of fulminant hepatic failure, 6 days after surgery. Postmortem liver biopsy revealed massive predominantly centrilobular hepatic necrosis.
authors.affiliation: Department of Surgery, PAF, Hospital, Faisal, Karachi. surgazhar@yahoo.com
authors.forename: Muhammad Azhar
authors.initials: MA
authors.lastname: Qureshi
authors.forename: Farrukh
authors.initials: F
authors.lastname: Saeed
authors.forename: Tassawar
authors.initials: T
authors.lastname: Hussain
mesh_terms: D000328:Adult; D018685:Anesthetics, Inhalation / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D017809:Fatal Outcome; D006221:Halothane / Q000009:adverse effects*; D006801:Humans; D017114:Liver Failure, Acute / Q000139:chemically induced* / Q000601:surgery; D008297:Male
chemical_list: D018685:Anesthetics, Inhalation; D006221:Halothane