title: Granular cell atypical fibroxanthoma: report of two cases.
abstract: Two cases of an uncommon histopathological variant of atypical fibroxanthoma (AFX) are described. Even though both lesions presented as clinically conventional atypical fibroxanthoma, histopathology disclosed a neoplasm composed of cells with granular change that was negative for S100 staining, and showed prominent pleomorphism, severe nuclear atypia, and a high mitotic index. Degenerative change may explain the granular phenotype in these two cases of AFX. The differential diagnosis with primitive nonneural granular cell tumor is discussed.
authors.affiliation: Department of Pathology, Virgen Macarena University Hospital, Seville, Spain. jjrios@us.es
authors.forename: Juan José
authors.initials: JJ
authors.lastname: Ríos-Martín
authors.forename: Mario Díaz
authors.initials: MD
authors.lastname: Delgado
authors.forename: David
authors.initials: D
authors.lastname: Moreno-Ramírez
authors.forename: Antonio
authors.initials: A
authors.lastname: García-Escudero
authors.forename: Ricardo
authors.initials: R
authors.lastname: González-Cámpora
mesh_terms: D000369:Aged, 80 and over; D049109:Cell Proliferation; D003937:Diagnosis, Differential; D005350:Fibroma / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology*; D016586:Granular Cell Tumor / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D008297:Male; D010641:Phenotype; D009418:S100 Proteins / Q000378:metabolism; D012878:Skin Neoplasms / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology*; D014973:Xanthomatosis / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology*
chemical_list: D009418:S100 Proteins