Interleukin-10 production by effector T cells: Th1 cells show self control.
Interleukin (IL)-10 is a cytokine that modulates both innate and adaptive immunity, primarily by exerting antiinflammatory effects. IL-10 was originally thought to be produced only by T helper (Th)2 cells, but is now known to be made by a variety of cell types. During many infections, CD4(+) T cells produce both interferon (IFN)-gamma, the signature Th1 cytokine, and IL-10. New data now show that the IL-10 produced by effector Th1 cells helps limit the collateral damage caused by exaggerated inflammation. But this control may also limit the effectiveness of the immune response, resulting in a failure to fully eliminate pathogens.
Trinchieri
Giorgio
G
Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA. trinchig@mail.nih.gov
D005786:Gene Expression Regulation / Q000276:immunology*; D007249:Inflammation / Q000276:immunology*; D016753:Interleukin-10 / Q000276:immunology*; D018448:Models, Immunological; D018417:Th1 Cells / Q000276:immunology*
D016753:Interleukin-10