title: Application of clinical proteomics in diagnosis and management of trauma patients.
abstract: Poly-trauma remains a medical entity with major implications, for patient's morbidity, mortality and healthcare economics. Advances in molecular medicine have improved diagnostic techniques in detecting devastating complication after major trauma. Patients at high risk of multiple organ dysfunction syndrome (MODS) or adult respiratory distress syndrome (ARDS), could be identified early, monitored and treated. Proteomics is the systematic evaluation of proteins produced by the cell under normal or pathological circumstances. Investigating protein production will allow us to identify and modify disease natural history and treatment. In this review, we summarise the proteomic methods currently applied in trauma research.
authors.affiliation: Academic Department of Trauma & Orthopaedic Surgery, School of Medicine, University of Leeds, Clarendon Wing, Floor A, Leeds, General Infirmary, Great George Street, Leeds, UK.
authors.forename: Kalliopi
authors.initials: K
authors.lastname: Alpantaki
authors.forename: Eleftherios
authors.initials: E
authors.lastname: Tsiridis
authors.forename: Hans-Christoph
authors.initials: HC
authors.lastname: Pape
authors.forename: Peter V
authors.initials: PV
authors.lastname: Giannoudis
mesh_terms: D019295:Computational Biology; D003627:Data Interpretation, Statistical; D006801:Humans; D010597:Pharmacogenetics; D040901:Proteomics / Q000379:methods*; D014194:Traumatology / Q000379:methods*; D014947:Wounds and Injuries / Q000628:therapy*