title: Relation of C-reactive protein to coronary collaterals in patients with stable angina pectoris and coronary artery disease.
abstract: The heterogeneity in the degree of collateralization among patients with coronary artery disease (CAD) is poorly understood. We sought to determine whether chronic subclinical inflammation is related to coronary collateral development in patients with chronic stable angina pectoris and obstructive CAD. High-sensitivity C-reactive protein (CRP) levels were measured in 177 patients with stable angina pectoris before coronary angiography. Multivariable logistic regression revealed an inverse graded association between CRP and the presence of coronary collaterals (Rentrop grade 1 to 3). Compared with patients in the first CRP tertile, the adjusted odds ratio for the presence of coronary collaterals was 0.70 (95% confidence interval, 0.33 to 1.52; p = 0.45) for patients in the second CRP tertile and 0.33 (95% confidence interval, 0.15 to 0.75; p = 0.008) for patients in the third CRP tertile (p for trend = 0.008). In conclusion, an inverse graded association exists between CRP and the presence of coronary collaterals in patients with stable angina pectoris.
authors.affiliation: Department of Cardiology, Rambam Medical Center, Haifa, Israel.
authors.forename: Arthur
authors.initials: A
authors.lastname: Kerner
authors.forename: Luis
authors.initials: L
authors.lastname: Gruberg
authors.forename: Alexander
authors.initials: A
authors.lastname: Goldberg
authors.forename: Ariel
authors.initials: A
authors.lastname: Roguin
authors.forename: Peretz
authors.initials: P
authors.lastname: Lavie
authors.forename: Lena
authors.initials: L
authors.lastname: Lavie
authors.forename: Walter
authors.initials: W
authors.lastname: Markiewicz
authors.forename: Rafael
authors.initials: R
authors.lastname: Beyar
authors.forename: Doron
authors.initials: D
authors.lastname: Aronson
mesh_terms: D000787:Angina Pectoris / Q000097:blood*; D002097:C-Reactive Protein / Q000378:metabolism*; D016009:Chi-Square Distribution; D003097:Collateral Circulation / Q000502:physiology*; D003324:Coronary Artery Disease / Q000097:blood*; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D018709:Statistics, Nonparametric
chemical_list: D002097:C-Reactive Protein