title: Electrochemical and photophysical properties of DNA metallo-intercalators containing the ruthenium(II) tris(1-pyrazolyl)methane unit.
abstract: Three new ruthenium(II) complexes containing the tris(1-pyrazolyl)methane (tpm) ligand have been prepared: [Ru(tpm)(L)(dppn)]n+ (where n = 1; L = Cl (5), n = 2; L = MeCN (6) and pyridine (7); dppn = benzo[i]dipyrido[3,2-a:2',3'-c]phenazine). Complex 6 was structurally characterized by single-crystal X-ray diffraction. Binding parameters of these complexes with calf thymus DNA are reported and compared to those obtained for a previously reported monocation, [RuCl(tpm)(dppz)]+. Binding studies with the dications and the synthetic oligonucleotides poly(dA).poly(dT) and poly(dG).poly(dC) have also been determined. Photophysical and electrochemical properties of 5-7 have been investigated and compared with their dipyridophenazine (dppz) analogues.
authors.affiliation: Department of Chemistry, University of Sheffield, Sheffield, U.K. S3 7HF.
authors.forename: Simon P
authors.initials: SP
authors.lastname: Foxon
authors.forename: Clive
authors.initials: C
authors.lastname: Metcalfe
authors.forename: Harry
authors.initials: H
authors.lastname: Adams
authors.forename: Michelle
authors.initials: M
authors.lastname: Webb
authors.forename: Jim A
authors.initials: JA
authors.lastname: Thomas
mesh_terms: D018360:Crystallography, X-Ray; D004247:DNA / Q000737:chemistry*; D004563:Electrochemistry; D007364:Intercalating Agents / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D009942:Organometallic Compounds / Q000737:chemistry*; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013237:Stereoisomerism
chemical_list: D007364:Intercalating Agents; D009942:Organometallic Compounds; C518356:ruthenium(II) tris(1-pyrazolyl)methane; D004247:DNA