Tissue microarrays characterise the clinical significance of a VEGF-A protein expression signature in gastrointestinal stromal tumours.
A tissue microarray analysis of 22 proteins in gastrointestinal stromal tumours (GIST), followed by an unsupervised, hierarchical monothetic cluster statistical analysis of the results, allowed us to detect a vascular endothelial growth factor (VEGF) protein overexpression signature discriminator of prognosis in GIST, and discover novel VEGF-A DNA variants that may have functional significance.
Salto-Tellez
M
M
Department of Pathology, Yong Loo Lin Faculty of Medicine, National University of Singapore, 5 Lower Kent Ridge Road, Singapore. patmst@nus.edu.sg
Nga
M E
ME
Han
H C
HC
Wong
A S-C
AS
Lee
C K
CK
Anuar
D
D
Ng
S S
SS
Ho
M
M
Wee
A
A
Chan
Y H
YH
Soong
R
R
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001483:Base Sequence; D002851:Chromatography, High Pressure Liquid; D016000:Cluster Analysis; D004252:DNA Mutational Analysis; D017931:DNA Primers; D046152:Gastrointestinal Stromal Tumors / Q000235:genetics / Q000378:metabolism* / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D008969:Molecular Sequence Data; D009154:Mutation; D016133:Polymerase Chain Reaction; D011379:Prognosis; D040081:Protein Array Analysis; D046888:Tissue Array Analysis; D042461:Vascular Endothelial Growth Factor A / Q000096:biosynthesis* / Q000235:genetics*
D017931:DNA Primers; D042461:Vascular Endothelial Growth Factor A