Development of a multifunctional platform for extra- and intracellular ionic activities recording.
We present the development of a multifunctional platform equipped with an array of silicon nitride micropipettes with dimensions allowing the implementation of extra- and intracellular operations. Micropipettes with outer diameter that ranges from 6 mum down to 300 nm and with walls thicknesses of 500 down to 150 nm are presented. The generic technology developed to fabricate these micropipettes has a number of advantages, including the ability to be implemented as ion-selective electrodes for (A) intracellular and (B) extracellular recordings and as (C) local drug microdispensers.
Guenat
O T
OT
Inst. of Microtechnol., Neuchatel Univ., Switzerland.
Boulard
G
G
Dufour
J-F
JF
de Rooij
N F
NF
Koudelka-Hep
M
M