Cytogenetic findings in pediatric renal cell carcinoma.
Adenocarcinomas of the kidney are rare childhood tumors. Only 30 cases with chromosomal abnormalities have been reported, and neither their karyotypic characteristics nor the molecular mechanisms behind their pathogenesis are clear, except for a special group of papillary tumors characterized by X-chromosome abnormalities. We have cytogenetically analyzed short-term cultured cells from two pediatric renal carcinomas, one papillary, and one chromophobe renal cell carcinoma, revealing the following karyotypes: 58-60,XX,-X,-1,+7,-8,-9,-11,-14,-15,+17,-18,-19,-21,-22 and 36,X,-X,-1,-2,-5,-6,-9,-10,-13,-17,-21/37,idem,+r/36,idem,-14,+1-2r, respectively. The findings indicate that subsets of pediatric renal cell carcinoma show karyotypes that are similar to their adult counterparts.
Soller
Maria Johansson
MJ
Department of Clinical Genetics, Lund University Hospital, SE-221 85 Lund, Sweden. maria.soller@med.lu.se
Kullendorff
Carl-Magnus
CM
Békássy
Albert N
AN
Alumets
Jan
J
Mertens
Fredrik
F
D000293:Adolescent; D002291:Carcinoma, Papillary / Q000235:genetics / Q000473:pathology*; D002292:Carcinoma, Renal Cell / Q000235:genetics / Q000473:pathology*; D002648:Child; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D006801:Humans; D007621:Karyotyping; D007680:Kidney Neoplasms / Q000235:genetics / Q000473:pathology*; D012303:Ring Chromosomes; D014407:Tumor Cells, Cultured