title: Noninvasive infrared imaging for quantitative assessment of tumor vasculature and response to therapy.
abstract: In this study we are investigating three infrared imaging techniques, thermography, multispectral imaging and Laser Doppler imaging (LDI) to assess parameters of vascularity in lesions of Kaposi's sarcoma (KS) and response to therapy. Thermography, multispectral imaging and LDI were recorded over the lesion and compare to normal skin either adjacent to the lesion or on the contralateral side. The KS lesions generally had increased temperature, blood volume (as measured by multispectral imaging) and blood flux (as measured by LDI) as compare to normal skin. After the treatment with experimental antiKS drug, temperature, blood volume and blood flow of the lesion were significantly reduced from the baseline. These techniques hold promise to assess physiological parameter in KS lesion and their changes with therapy.
authors.affiliation: Lab. of Integrative & Med. Biophys., Nat. Inst. of Health, Bethesda, MD, USA.
authors.forename: Moinuddin
authors.initials: M
authors.lastname: Hassan
authors.forename: David
authors.initials: D
authors.lastname: Hattery
authors.forename: Abby
authors.initials: A
authors.lastname: Vogel
authors.forename: Victor
authors.initials: V
authors.lastname: Chernomordik
authors.forename: Stavros
authors.initials: S
authors.lastname: Demos
authors.forename: Karen
authors.initials: K
authors.lastname: Aleman
authors.forename: Richard
authors.initials: R
authors.lastname: Little
authors.forename: Robert
authors.initials: R
authors.lastname: Yarchoan
authors.forename: Amir H
authors.initials: AH
authors.lastname: Gandjbakhche