Simplified synthesis of 3-(1-arylsulfonylalkyl) indoles and their reaction with Reformatsky reagents.
A simple procedure for the preparation of 3-(1-arylsulfonyl-alkyl) indoles by three-component condensation of indoles, carbonyls, and arenesulfinic acids is presented. The obtained products undergo a Reformatsky reaction leading to alkyl 3-(3-indolyl) alkanoates and (3-indolyl) ketones.
Palmieri
Alessandro
A
Dipartimento di Scienze Chimiche, Universita di Camerino, via S. Agostino 1, I-62032 Camerino, Italy.
Petrini
Marino
M