title: Salvaging the limb salvage: management of complications following endoprosthetic reconstruction for tumours around the knee.
abstract: BACKGROUND
  Limb-salvage surgery, including endoprosthetic reconstruction after tumour resection, has become the standard management for local control of tumours around the knee. As the nature of surgery is technically complex and demanding, there is potential for significant morbidity arising from complications. This study describes our experience with complications following endoprosthetic reconstruction around the knee.
  
  
  METHODS
  Retrospective analysis of consecutive resections and endoprosthetic reconstructions for tumours around the knee between 1996 and September 2005 performed at St Vincent's Hospital, Melbourne.
  
  
  RESULTS
  Fifty consecutive cases were reviewed, with a median follow-up of 24.5 (range, 2-124) months. Median age was 41 (range, 13-79) years. Tumour types included 38 primary musculoskeletal malignancies, 8 metastatic tumours, 2 bony lymphomas and 2 benign lesions. There were eight deaths, nine cases of subsequent metastatic spread and no local recurrences. There were six cases of deep infection, two each of non-resolving nerve palsy, fracture and mechanical wear, and one each of symptomatic patellofemoral impingement, aseptic loosening and intraoperative popliteal artery trauma. Five patients required endoprosthetic revision, and three subsequent amputations were described. Excellent functional outcome and emotional acceptance was observed amongst patients that underwent revision.
  
  
  CONCLUSIONS
  Resection and endoprosthetic reconstruction of tumours around the knee is both technically challenging and resource-intensive. It is imperative that morbidity from complications is limited through the minimisation of their incidence and the provision of optimal management. This series demonstrates that good patient outcomes can be achieved in specialist centres with experienced surgeons and adoption of a multidisciplinary approach.
authors.affiliation: Department of Orthopaedics, St. Vincent's Hospital, PO Box 2900, Fitzroy, Melbourne, Vic. 3065, Australia.
authors.forename: I-W
authors.initials: IW
authors.lastname: Sim
authors.forename: L F
authors.initials: LF
authors.lastname: Tse
authors.forename: E T
authors.initials: ET
authors.lastname: Ek
authors.forename: G J
authors.initials: GJ
authors.lastname: Powell
authors.forename: P F M
authors.initials: PF
authors.lastname: Choong
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000671:Amputation, Surgical; D019645:Arthroplasty, Replacement, Knee / Q000009:adverse effects; D001859:Bone Neoplasms / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007431:Intraoperative Complications; D007592:Joint Diseases / Q000601:surgery*; D007595:Joint Prosthesis; D007719:Knee Joint / Q000601:surgery*; D023821:Limb Salvage; D008297:Male; D008875:Middle Aged; D019042:Muscle Neoplasms / Q000601:surgery; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000601:surgery*; D011150:Popliteal Artery / Q000293:injuries; D011183:Postoperative Complications; D011475:Prosthesis Failure; D012086:Reoperation; D012189:Retrospective Studies; D013530:Surgical Wound Infection / Q000209:etiology; D015996:Survival Rate; D016896:Treatment Outcome