title: [Dysregulation of cytokine production by mononuclear cells of peripheral blood in persistent infection with a virus of tick-borne encephalitis].
abstract: Tick-borne encephalitis is accompanied by dysregulation of cytokine production of mononuclear leucocytes of peripheral blood. The changes of production of IFN-r by mononuclear leucocytes of peripheral blood positively correlated with a degree of activity of pathological process and intensity of clinical symptoms of neuroninfection. On the contrary, secretion of IL-12 mononuclears directly correlated with virus persistence in the organism and does not depend on clinical presentation of the disease.
authors.forename: N V
authors.initials: NV
authors.lastname: Riazantseva
authors.forename: V V
authors.initials: VV
authors.lastname: Novitskiĭ
authors.forename: A P
authors.initials: AP
authors.lastname: Zima
authors.forename: N G
authors.initials: NG
authors.lastname: Zhukova
authors.forename: N P
authors.initials: NP
authors.lastname: Pirogova
authors.forename: I O
authors.initials: IO
authors.lastname: Naslednikova
authors.forename: A V
authors.initials: AV
authors.lastname: Lepekhin
mesh_terms: D000293:Adolescent; D000328:Adult; D004675:Encephalitis, Tick-Borne / Q000097:blood / Q000276:immunology / Q000503:physiopathology; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D007075:Immunoglobulin M / Q000276:immunology; D007371:Interferon-gamma / Q000096:biosynthesis* / Q000097:blood / Q000276:immunology; D018664:Interleukin-12 / Q000096:biosynthesis* / Q000097:blood / Q000276:immunology; D007963:Leukocytes, Mononuclear / Q000276:immunology* / Q000378:metabolism*; D008297:Male; D008875:Middle Aged
chemical_list: D007074:Immunoglobulin G; D007075:Immunoglobulin M; D018664:Interleukin-12; D007371:Interferon-gamma