Inflammatory tales of liver cancer.
Cell culture studies have established NF-kappaB's critical role in cancer cell survival and proliferation and led to the clinical use of NF-kappaB inhibitors. However, a paper in this issue of Cancer Cell reveals an anticancer function for NF-kappaB in a mouse model where NF-kappaB activity is lost specifically in hepatocytes. These studies suggest careful examination of NF-kappaB inhibitors as a therapeutic modality for cancer.
Hoffmann
Alexander
A
Signaling Systems Laboratory, University of California, San Diego, La Jolla, CA 92093, USA.
Xia
Yifeng
Y
Verma
Inder M
IM
D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D053200:Fas-Associated Death Domain Protein / Q000235:genetics / Q000502:physiology; D005234:Fatty Liver / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D022781:Hepatocytes / Q000166:cytology* / Q000378:metabolism; D051550:I-kappa B Kinase / Q000235:genetics / Q000502:physiology; D007249:Inflammation / Q000209:etiology; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics / Q000502:physiology*; D016350:Leucine Zippers; D008113:Liver Neoplasms / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D016328:NF-kappa B / Q000235:genetics / Q000378:metabolism*
D053200:Fas-Associated Death Domain Protein; D047908:Intracellular Signaling Peptides and Proteins; C514981:NEMO protein, mouse; D016328:NF-kappa B; D051550:I-kappa B Kinase; C496562:Ikbkb protein, mouse