A search for a mutation of the Aiolos phosphorylation domain in lymphocytes from patients with leukemia.
We examined whether phosphorylation of Aiolos in primary human lymphocytes is part of the malignant transformation in leukemia. By analyzing mutations at a restriction site we show here that impairment of Aiolos activity in human leukemia is not based on deficient phosphorylation as had been demonstrated in experiments in vitro.
Antica
Mariastefania
M
Dubravcic
Klara
K
Weber
I
I
Raic
Ljubica
L
Labar
Boris
B
Batinic
Drago
D
D004252:DNA Mutational Analysis; D006801:Humans; D051740:Ikaros Transcription Factor; D007938:Leukemia / Q000097:blood* / Q000235:genetics*; D008214:Lymphocytes / Q000166:cytology*; D009154:Mutation; D010766:Phosphorylation; D017434:Protein Structure, Tertiary; D015534:Trans-Activators / Q000097:blood* / Q000737:chemistry / Q000235:genetics*; D014157:Transcription Factors; D016335:Zinc Fingers
C106285:IKZF3 protein, human; D015534:Trans-Activators; D014157:Transcription Factors; D051740:Ikaros Transcription Factor