title: Approaches to high throughput physical organic chemistry.
abstract: High throughput (HT) techniques are now extensively used for the synthesis of libraries of several thousands of compounds. More recently, HT methods began to be applied to other areas, such as physical organic chemistry. This has allowed for instance the development of tools for HT reaction assessment, HT kinetic and thermodynamic measurements, and physicochemical property profiling, using a broad set of analytical tools, ranging from mass spectrometry to image analysis based techniques. This article provides an overview of recent HT physical organic chemistry techniques. Special attention is given to the application of quantitative analytical constructs for HT monomer reactivity profiling and HT evaluation of Hammett parameters.
authors.affiliation: Combinatorial Centre of Excellence, School of Chemistry, West Mains Road, University of Edinburgh, Edinburgh, UKEH9 3JJ.
authors.forename: Christophe
authors.initials: C
authors.lastname: Portal
authors.forename: Mark
authors.initials: M
authors.lastname: Bradley
mesh_terms: D002625:Chemistry, Organic / Q000379:methods*; D020650:Combinatorial Chemistry Techniques; D015394:Molecular Structure; D009930:Organic Chemicals / Q000138:chemical synthesis / Q000737:chemistry*; D013816:Thermodynamics
chemical_list: D009930:Organic Chemicals