title: A novel controlled porosity osmotic pump system for sodium ferulate.
abstract: A controlled porosity osmotic pump (CPOP) delivery system for sodium ferulate was prepared with cellulose acetate (CA) as semipermeable membrane, polyethyleneglycol 400 (PEG 400) as channeling agent and dibutylphthalate (DBP) as plasticizer and release controller. Effects of coating levels, PEG and DBP content and amount of sodium chloride on in vitro release were studied. Coating formulations were optimized by a L9 (34) orthogonal array design (OAD) with three factors at three levels using statistical analysis. Controlled porosity osmotic pump tablets of sodium ferulate made with the optimal formulation were found to have good in vitro and in vivo release characteristics.
authors.affiliation: Key Laboratory of Drug Targeting and Novel Drug Delivery Systems, West China School of Pharmacy, Sichuan University, No. 17, Block 3, Southern Renmin Road, Chengdu, Sichuan 610041, P R China.
authors.forename: Lili
authors.initials: L
authors.lastname: He
authors.forename: Tao
authors.initials: T
authors.lastname: Gong
authors.forename: Dong
authors.initials: D
authors.lastname: Zhao
authors.forename: Zhi-Rong
authors.initials: ZR
authors.lastname: Zhang
authors.forename: Lili
authors.initials: L
authors.lastname: Li
mesh_terms: D000465:Algorithms; D000818:Animals; D001682:Biological Availability; D002138:Calibration; D002482:Cellulose / Q000031:analogs & derivatives; D002626:Chemistry, Pharmaceutical; D002851:Chromatography, High Pressure Liquid; D003373:Coumaric Acids / Q000008:administration & dosage* / Q000493:pharmacokinetics; D003993:Dibutyl Phthalate; D004285:Dogs; D004343:Drug Implants; D005079:Excipients; D005260:Female; D008297:Male; D009994:Osmolar Concentration; D010968:Plasticizers; D011092:Polyethylene Glycols; D016062:Porosity; D012965:Sodium Chloride / Q000737:chemistry; D013056:Spectrophotometry, Ultraviolet; D013608:Tablets, Enteric-Coated
chemical_list: D003373:Coumaric Acids; D004343:Drug Implants; D005079:Excipients; D010968:Plasticizers; D013608:Tablets, Enteric-Coated; D003993:Dibutyl Phthalate; C005062:acetylcellulose; D011092:Polyethylene Glycols; D012965:Sodium Chloride; D002482:Cellulose; C004999:ferulic acid