title: Significance of collagenase 3 (matrix metalloproteinase 13) in invasive bladder cancer: correlation with pathological parameters.
abstract: OBJECTIVE
  To determine if collagenase 3 expression is associated with stage progression and prognosis of bladder cancer.
  
  
  METHODS
  Immunohistochemical staining for collagenase 3 was carried out on serial sections from specimens of 42 patients (32 males and 10 females) who underwent radical cystectomy for bladder cancer (median follow-up, 67.2 +/- 5.99 months).
  
  
  RESULTS
  Immunohistochemical expression of collagenase 3 was detected in 13 (31%) patients. Pathological stage was pT2 in 12 (28.57%) patients, pT3a in 7 (16.6%), pT3b in 21 (50%) and pT4 in 2 (4.76%). Four tumours (9.52%) were grade II and 38 (90.47%) were grade III. Stage and tumours >3 cm in size were associated with bladder cancer progression-free survival and overall survival. We did not find any statistical differences with collagenase 3 expression related with stage and size.
  
  
  CONCLUSIONS
  Immunohistochemical expression of matrix metalloproteinase 13 in invasive bladder cancer is not useful as marker for transformation and invasion. These findings should be evaluated in large multicentre prospective trials.
authors.affiliation: Department of Urology and Pathology, University of Oviedo, Oviedo, Spain. orfaba@hotmail.com
authors.forename: O
authors.initials: O
authors.lastname: Rodríguez Faba
authors.forename: J M
authors.initials: JM
authors.lastname: Fernández Gómez
authors.forename: J
authors.initials: J
authors.lastname: Palou Redorta
authors.forename: S
authors.initials: S
authors.lastname: Escaf Barmadah
authors.forename: F
authors.initials: F
authors.lastname: Vizoso
authors.forename: H
authors.initials: H
authors.lastname: Villavicencio Mavrich
mesh_terms: D000368:Aged; D002295:Carcinoma, Transitional Cell / Q000201:enzymology* / Q000473:pathology* / Q000601:surgery; D015653:Cystectomy; D018450:Disease Progression; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D053509:Matrix Metalloproteinase 13 / Q000096:biosynthesis*; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D001749:Urinary Bladder Neoplasms / Q000201:enzymology* / Q000473:pathology* / Q000601:surgery
chemical_list: D053509:Matrix Metalloproteinase 13