[Fluoride and bone metabolism].
Fluoride (F) is an essential trace element which is involved in the skeletal systems of teeth and bone. F increases proliferation of osteoblastic cells and stimulates bone formation. F inhibits acid phosphatase activity in osteoblastic cells and induces an increases in tyrosin phosphorylated protein, leading to cell proliferation. Also, the activation of G protein by F is important in the cellular mechanism of F action in osteoblastic cells. F also has inhibitory effects on osteoclastic bone resorption. The oral administration of F solution has stimulatory effects on bone formation in various animal models. Moreover, the intake of F with comparatively low doses may have beneficial effects in the development of bone mineral density and fracture in human.
Yamaguchi
Masayoshi
M
University of Shizuoka, Graduate School of Nutritional Sciences, Laboratory of Endocrinology and Molecular Metabolism.
D000135:Acid Phosphatase / Q000037:antagonists & inhibitors; D000818:Animals; D015519:Bone Density / Q000187:drug effects; D001862:Bone Resorption / Q000517:prevention & control; D001842:Bone and Bones / Q000378:metabolism*; D049109:Cell Proliferation / Q000187:drug effects; D005459:Fluorides / Q000494:pharmacology / Q000627:therapeutic use; D050723:Fractures, Bone / Q000517:prevention & control; D019204:GTP-Binding Proteins / Q000378:metabolism; D006801:Humans; D010006:Osteoblasts / Q000166:cytology / Q000201:enzymology; D010012:Osteogenesis / Q000187:drug effects; D010024:Osteoporosis / Q000517:prevention & control; D013268:Stimulation, Chemical
D000135:Acid Phosphatase; D019204:GTP-Binding Proteins; D005459:Fluorides