title: Myocardial protection by continuous, blood, antegrade-retrograde cardioplegia in rabbits.
abstract: OBJECTIVE
  To study the effectiveness of the continuous, blood, antegrade-retrograde cardioplegia in an experimental model of isolated heart, evaluating ventricular function.
  
  
  METHODS
  Rabbits were divided into four groups: Control--C(n=10); ischemic crystalloid cardioplegia--IC(n=10); ischemic blood cardioplegia--IB(n=10); ischemic non cardioplegia--INC(n=10). After the ischemic protocol period the ventricular function was analyzed by the intra-ventricular balloon technique.
  
  
  RESULTS
  the intra-ventricular developed pressure (IVDP) was: C(92.90 +/- 6.86mmHg); IC(77.78 +/- 6.15mmHg); IB(93.64 +/- 5.09mmHg); INC(39.46 +/- 8.91mmHg) p< 0.005. The first derivative of intra-ventricular pressure in its positive deflection was: C(1137.50 +/- 92.23mmHg/sec); IC(1130.62 +/- 43.78mmHg/sec); IB(1187.58 +/- 88.38mmHg/sec); INC(620.02 +/- 43.80mmHg/se) p<0.005. The first derivate pressure in its negative deflection was: C(770.00 +/- 73.41mmHg/sec); IC(610.03 +/- 47.43mmg/sec); IB(762.53 +/- 46.02mmHg/sec); INC(412.35 +/- 84.36mmHg/sec) p< 0,005. The stress-strain angular logarithmic coefficient was: C(0.108 +/- 0.02); IC(0.159 +/- 0.038); IB(0.114 +/- 0.016); INC(0.175 +/- 0.038) p< 0.05.
  
  
  CONCLUSIONS
  The ischemic group protected by blood cardioplegia showed better ventricular function than ischemic group protected by crystalloid cardioplegia and the non protected group.
authors.affiliation: Surgical Research Laboratory, Botucatu Faculty of Medicine, State University of São Paulo, 18.618-000 Botucatu, SP, Brazil. asmartinsbtu@uol.com.br
authors.forename: Antônio Sérgio
authors.initials: AS
authors.lastname: Martins
authors.forename: Marcos Augusto de Moraes
authors.initials: MA
authors.lastname: Silva
authors.forename: Carlos Roberto
authors.initials: CR
authors.lastname: Padovani
authors.forename: Beatriz Boljokian
authors.initials: BB
authors.lastname: Matsubara
authors.forename: Domingo Marcolino
authors.initials: DM
authors.lastname: Braile
authors.forename: Antonio José Maria
authors.initials: AJ
authors.lastname: Catâneo
mesh_terms: D000818:Animals; D001769:Blood; D002314:Cardioplegic Solutions / Q000494:pharmacology*; D000077324:Crystalloid Solutions; D004195:Disease Models, Animal; D005260:Female; D006324:Heart Arrest, Induced / Q000379:methods*; D007423:Intra-Aortic Balloon Pumping; D007552:Isotonic Solutions / Q000494:pharmacology; D008297:Male; D015428:Myocardial Reperfusion Injury / Q000517:prevention & control*; D011817:Rabbits; D013314:Stress, Mechanical; D016278:Ventricular Function, Right; D017725:Ventricular Pressure / Q000187:drug effects
chemical_list: D002314:Cardioplegic Solutions; D000077324:Crystalloid Solutions; D007552:Isotonic Solutions