Clinical assessment of motor function: a processes oriented instrument based on a speed-accuracy trade-off paradigm.
In this study, we developed a digitizing tablet-based instrument for the clinical assessment of human voluntary movements targeting motor processes of planning, programming and execution. The tool was used to investigate an adaptation of Fitts' reciprocal tapping task [10], comprising four conditions, each of them modulated by three indices of difficulty related to the amplitude of movement required. Temporal, spatial and sequential constraints underlying the various conditions allowed the intricate motor processes to be dissociated. Data obtained from a group of elderly healthy subjects (N=50) were in agreement with the literature on motor control, in the temporal and spatial domains. Speed constraints generated gains in the temporal domain and costs in the spatial one, while spatial constraints generated gain in the spatial domain and costs in the temporal one; finally, sequential constraints revealed the integrative nature of the cognitive operations involved in motor production. This versatile instrument proved capable of providing quantitative, accurate and sensitive measures of the various processes sustaining voluntary movement in healthy subjects. Altogether, analyses performed in this study generated a theoretical framework and reference data which could be used in the future for the clinical assessment of patients with various movement disorders, in particular Parkinson's disease.
Christe
Blaise
B
Neuropsychology Unit, Department of Neurology, Geneva University Hospitals and Medical School, Switzerland. blaise.christe@hcuge.ch
Burkhard
Pierre R
PR
Pegna
Alan J
AJ
Mayer
Eugene
E
Hauert
Claude-Alain
CA
D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008959:Models, Neurological; D009048:Motor Skills / Q000502:physiology*; D009068:Movement / Q000502:physiology*; D009069:Movement Disorders / Q000175:diagnosis* / Q000503:physiopathology; D011930:Reaction Time / Q000502:physiology*; D012016:Reference Values; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013647:Task Performance and Analysis