[Neuropsychology of mildly disabled patients with relapsing-remitting multiple sclerosis].
Previous papers have mainly demonstrated the presence of cognitive impairment in patients with multiple sclerosis (MS), these changes have been traditionally associated with the later stages of the disease. In the current study, a comprehensive neuropsychological battery was administered to 216 relapsing-remitting MS patients with mild clinical disability (EDSS<or=3.5) and to 35 healty controls. The results show the presence of significant memory impairment: learning rate of list of words; reproduction visual memory; and long term verbal memory of texts, and information processing speed. We also observed greeter incidence of depressive symptoms in patients. And a little relation of the cognitive deficits with the clinical variables in these phase of the disease.
Santiago Rolanía
Olga
O
Unidad de Esclerosis Múltiple (L'Hosptalet de Llobregat, Barcelona), Spain. asantiago@campus.voc.es
Guàrdia Olmos
Joan
J
Arbizu Urdiain
Txomin
T
D000328:Adult; D003072:Cognition Disorders / Q000453:epidemiology / Q000209:etiology*; D003863:Depression / Q000453:epidemiology / Q000209:etiology; D006233:Persons with Disabilities / Q000523:psychology*; D005260:Female; D006801:Humans; D007859:Learning Disabilities / Q000453:epidemiology / Q000209:etiology; D008297:Male; D008569:Memory Disorders / Q000453:epidemiology / Q000209:etiology*; D008875:Middle Aged; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000523:psychology*; D009483:Neuropsychological Tests; D011340:Problem Solving; D013064:Speech Disorders / Q000453:epidemiology / Q000209:etiology; D013850:Thinking; D014706:Verbal Learning