Quo vadis porphyrin chemistry?
This review summarizes recent developments in the area of porphyrin chemistry in the direction of biological applications. Novel synthetic methodologies are reviewed for porphyrin synthesis, porphyrin analog synthesis, stable porphyrinogens -- calixpyrroles, expanded porphyrins. Unique biological properties of those compounds are desribed with focus on photodynamic therapy (PDT) and molecular recognition properties. Special attentions given to metalloporphyrins with potential to affect heme degradation and CO formation.
Král
V
V
Department of Analytical Chemistry, Institute of Chemical Technology, Prague, Czech Republic.
Králová
J
J
Kaplánek
R
R
Bríza
T
T
Martásek
P
P
D002248:Carbon Monoxide / Q000378:metabolism; D006418:Heme / Q000378:metabolism; D008954:Models, Biological; D010778:Photochemotherapy; D011166:Porphyrins / Q000737:chemistry* / Q000627:therapeutic use
D011166:Porphyrins; D006418:Heme; D002248:Carbon Monoxide