[Pregnancy outcomes following pulsatile GnRH treatment: results of a large multicenter retrospective study].
OBJECTIVE
The aim of the present study was to evaluate the efficacy of pulsatile GnRH treatment in a large French cohort of patients with hypogonadotropic hypogonadism.


METHODS
A retrospective study involving all women treated with pulsatile GnRH, over a 3-year period, in 24 French centers. Pregnancy rate and pregnancy outcome were the criteria for evaluation.


RESULTS
The study included 248 women who received a total of 829 treatment cycles. The treatment routes of administration were subcutaneous (56.1% of the patients), intravenous (31.1%), or both (12.7%). The pregnancy rate per treatment cycle was 25%, while the mean number of cycles needed to obtain a pregnancy was 2.8+/-1.7. The miscarriage rate was 8.2% and the multiple pregnancy rates 8.8%. The mean delivery term was 38.4+/-2.4 weeks and the mean birth weight was 3009+/-561 g. No severe ovarian hyperstimulation was recorded. Ovarian cysts occurred in 2.3% of the treatment cycles, local allergies in 1.7%.


CONCLUSIONS
Our study has shown that pulsatile GnRH treatment was well tolerated, without severe hyperstimulation. It induced a good pregnancy rate with favorable pregnancy outcomes.
Christin-Maitre
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Service d'Endocrinologie, Hôpital Saint-Antoine, Assistance Publique-Hôpitaux de Paris, 184, rue du Faubourg-Saint-Antoine, Université Paris-VI, UPRES 1533, 75012 Paris cedex, France. sophie.christin-maitre@sat.aphp.fr
de Crécy
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D000279:Administration, Cutaneous; D000328:Adult; D015331:Cohort Studies; D005260:Female; D005300:Fertility Agents, Female / Q000008:administration & dosage*; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage*; D006801:Humans; D007006:Hypogonadism / Q000150:complications*; D007275:Injections, Intravenous; D011247:Pregnancy; D011256:Pregnancy Outcome; D018873:Pregnancy Rate; D012189:Retrospective Studies
D005300:Fertility Agents, Female; D007987:Gonadotropin-Releasing Hormone