Gold(III)-catalyzed double hydroamination of o-alkynylaniline with terminal alkynes leading to N-vinylindoles.
A highly efficient double-hydroamination reaction of o-alkynylanilines with terminal alkynes leading to N-alkenylindoles was developed by using gold(III) as a catalyst under neat conditions. [reaction: see text].
Zhang
Yuhua
Y
Department of Chemistry, Tulane University, New Orleans, Louisiana 70118, USA.
Donahue
James P
JP
Li
Chao-Jun
CJ
D000480:Alkynes / Q000737:chemistry*; D000586:Amination; D000814:Aniline Compounds / Q000737:chemistry; D002384:Catalysis; D018360:Crystallography, X-Ray; D006046:Gold / Q000737:chemistry*; D007211:Indoles / Q000138:chemical synthesis*; D008958:Models, Molecular; D014753:Vinyl Compounds / Q000138:chemical synthesis*
D000480:Alkynes; D000814:Aniline Compounds; D007211:Indoles; D014753:Vinyl Compounds; D006046:Gold