title: Design, synthesis and biological evaluation of a macrocyclic discodermolide/dictyostatin hybrid.
abstract: A 22-membered macrocyclic discodermolide/dictyostatin hybrid has been designed and synthesised; biological evaluation against a range of human cancer cell lines revealed significant levels of growth inhibition.
authors.affiliation: University Chemical Laboratory, Lensfield Road, Cambridge, UK CB2 1EW. ip100@cam.ac.uk
authors.forename: Ian
authors.initials: I
authors.lastname: Paterson
authors.forename: Nicola M
authors.initials: NM
authors.lastname: Gardner
mesh_terms: D000473:Alkanes / Q000737:chemistry*; D002219:Carbamates / Q000737:chemistry*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D006801:Humans; D007783:Lactones / Q000737:chemistry*; D047028:Macrocyclic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D018942:Macrolides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D008958:Models, Molecular; D015394:Molecular Structure; D011753:Pyrones / Q000737:chemistry*
chemical_list: D000473:Alkanes; D002219:Carbamates; D007783:Lactones; D047028:Macrocyclic Compounds; D018942:Macrolides; D011753:Pyrones; C470814:dictyostatin; C071229:discodermolide