Myocardial protection by continuous, blood, antegrade-retrograde cardioplegia in rabbits.
OBJECTIVE
To study the effectiveness of the continuous, blood, antegrade-retrograde cardioplegia in an experimental model of isolated heart, evaluating ventricular function.


METHODS
Rabbits were divided into four groups: Control--C(n=10); ischemic crystalloid cardioplegia--IC(n=10); ischemic blood cardioplegia--IB(n=10); ischemic non cardioplegia--INC(n=10). After the ischemic protocol period the ventricular function was analyzed by the intra-ventricular balloon technique.


RESULTS
the intra-ventricular developed pressure (IVDP) was: C(92.90 +/- 6.86mmHg); IC(77.78 +/- 6.15mmHg); IB(93.64 +/- 5.09mmHg); INC(39.46 +/- 8.91mmHg) p< 0.005. The first derivative of intra-ventricular pressure in its positive deflection was: C(1137.50 +/- 92.23mmHg/sec); IC(1130.62 +/- 43.78mmHg/sec); IB(1187.58 +/- 88.38mmHg/sec); INC(620.02 +/- 43.80mmHg/se) p<0.005. The first derivate pressure in its negative deflection was: C(770.00 +/- 73.41mmHg/sec); IC(610.03 +/- 47.43mmg/sec); IB(762.53 +/- 46.02mmHg/sec); INC(412.35 +/- 84.36mmHg/sec) p< 0,005. The stress-strain angular logarithmic coefficient was: C(0.108 +/- 0.02); IC(0.159 +/- 0.038); IB(0.114 +/- 0.016); INC(0.175 +/- 0.038) p< 0.05.


CONCLUSIONS
The ischemic group protected by blood cardioplegia showed better ventricular function than ischemic group protected by crystalloid cardioplegia and the non protected group.
Martins
Antônio Sérgio
AS
Surgical Research Laboratory, Botucatu Faculty of Medicine, State University of São Paulo, 18.618-000 Botucatu, SP, Brazil. asmartinsbtu@uol.com.br
Silva
Marcos Augusto de Moraes
MA
Padovani
Carlos Roberto
CR
Matsubara
Beatriz Boljokian
BB
Braile
Domingo Marcolino
DM
Catâneo
Antonio José Maria
AJ
D000818:Animals; D001769:Blood; D002314:Cardioplegic Solutions / Q000494:pharmacology*; D000077324:Crystalloid Solutions; D004195:Disease Models, Animal; D005260:Female; D006324:Heart Arrest, Induced / Q000379:methods*; D007423:Intra-Aortic Balloon Pumping; D007552:Isotonic Solutions / Q000494:pharmacology; D008297:Male; D015428:Myocardial Reperfusion Injury / Q000517:prevention & control*; D011817:Rabbits; D013314:Stress, Mechanical; D016278:Ventricular Function, Right; D017725:Ventricular Pressure / Q000187:drug effects
D002314:Cardioplegic Solutions; D000077324:Crystalloid Solutions; D007552:Isotonic Solutions