title: In search of partners: linking extracellular proteases to substrates.
abstract: Proteases function as molecular switches in signalling circuits at the cell surface and in the extracellular milieu. In light of the many proteases that are encoded by the genome, and the even larger number of bioactive substrates, it is crucial to identify which proteases cleave a particular substrate and which substrates individual proteases cleave. Elucidating the substrate degradomes of proteases will help us to understand the function of proteases in development and disease and to validate proteases as drug targets.
authors.affiliation: The UBC Centre for Blood Research, CBCRA Program in Breast Cancer Metastasis, Department of Oral Biological & Medical Sciences, University of British Columbia, 4.401 Life Sciences Center, Vancouver, British Columbia, V6T 1Z3, Canada.
authors.forename: Christopher M
authors.initials: CM
authors.lastname: Overall
authors.forename: Carl P
authors.initials: CP
authors.lastname: Blobel
mesh_terms: D000818:Animals; D006801:Humans; D010447:Peptide Hydrolases / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D040901:Proteomics / Q000379:methods*; D013379:Substrate Specificity
chemical_list: D010447:Peptide Hydrolases