title: Vascular endothelial growth factor gene polymorphisms in ovarian cancer.
abstract: BACKGROUND
  Polymorphisms within the vascular endothelial growth factor (VEGF) gene, the most important regulator of angiogenesis and vascular permeability, were shown to be independently associated with an impaired prognosis in various malignancies. No data have been reported in ovarian cancer.
  
  
  METHODS
  In the present multi-center study, we examined three common polymorphisms within the VEGF gene (VEGF +405G/C, VEGF -460C/T, and VEGF +936C/T) in 553 Caucasian patients with ovarian cancer using pyrosequencing.
  
  
  RESULTS
  The three investigated polymorphisms did not correlate with any of the investigated clinico-pathological parameters. In univariate and multivariate models, only FIGO stage and patient's age at diagnosis, but not any polymorphism or any haplotype were correlated with patients' overall survival.
  
  
  CONCLUSIONS
  In our large multi-center study, the investigated VEGF gene polymorphisms were not associated with prognosis in patients with ovarian cancer.
authors.affiliation: Department of Obstetrics and Gynecology, Medical University of Vienna, A-1090 Vienna, Währinger Gürtel 18-20, Austria.
authors.forename: Stephan
authors.initials: S
authors.lastname: Polterauer
authors.forename: Christoph
authors.initials: C
authors.lastname: Grimm
authors.forename: Alexander
authors.initials: A
authors.lastname: Mustea
authors.forename: Nicole
authors.initials: N
authors.lastname: Concin
authors.forename: Berno
authors.initials: B
authors.lastname: Tanner
authors.forename: Falk
authors.initials: F
authors.lastname: Thiel
authors.forename: Georg
authors.initials: G
authors.lastname: Heinze
authors.forename: Alexander
authors.initials: A
authors.lastname: Reinthaller
authors.forename: Robert
authors.initials: R
authors.lastname: Zeillinger
authors.forename: Lukas A
authors.initials: LA
authors.lastname: Hefler
mesh_terms: D000368:Aged; D005260:Female; D005838:Genotype; D006801:Humans; D015810:Linkage Disequilibrium; D008875:Middle Aged; D009367:Neoplasm Staging; D009389:Neovascularization, Pathologic / Q000235:genetics; D010051:Ovarian Neoplasms / Q000098:blood supply / Q000235:genetics* / Q000473:pathology; D011110:Polymorphism, Genetic; D011379:Prognosis; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics*
chemical_list: D042461:Vascular Endothelial Growth Factor A