title: Maximum a posteriori (MAP) estimator for polymerase chain reaction (PCR) processes.
abstract: A maximum a posteriori (MAP) estimator for polymerase chain reaction (PCR) assays is presented. The estimation relies on the replication efficiencies of the PCR assay and the observed end-point concentration of the PCR product at an arbitrary cycle. This derivation is carried out in view of the stochastic progression of the amplicons, and the assumption that the end-point concentrations for any particular initial value have a jointly Gaussian distribution. In addition, we provide an extension for the estimator which can be applied to various quantitative PCR assays.
authors.affiliation: Dept. of Electr. Eng., Stanford Univ., CA, USA.
authors.forename: Hossein
authors.initials: H
authors.lastname: Kakavand
authors.forename: Deirdre
authors.initials: D
authors.lastname: O'brien
authors.forename: Arjang
authors.initials: A
authors.lastname: Hassibi
authors.forename: Thomas H
authors.initials: TH
authors.lastname: Lee