Discovery of non-nucleoside inhibitors of HIV-1 reverse transcriptase competing with the nucleotide substrate.
Maga
Giovanni
G
Istituto di Genetica Molecolare, IGM-CNR, Via Abbiategrasso 207, 27100 Pavia, Italy.
Radi
Marco
M
Zanoli
Samantha
S
Manetti
Fabrizio
F
Cancio
Reynel
R
Hübscher
Ulrich
U
Spadari
Silvio
S
Falciani
Chiara
C
Terrazas
Montserrat
M
Vilarrasa
Jaume
J
Botta
Maurizio
M
D018360:Crystallography, X-Ray; D054303:HIV Reverse Transcriptase / Q000037:antagonists & inhibitors* / Q000235:genetics; D008958:Models, Molecular; D009154:Mutation; D009711:Nucleotides / Q000378:metabolism*; D011487:Protein Conformation; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology*; D018894:Reverse Transcriptase Inhibitors / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology*
D009711:Nucleotides; D011743:Pyrimidines; D018894:Reverse Transcriptase Inhibitors; C519627:TNK-651; D054303:HIV Reverse Transcriptase