title: [Synthesis and antitumor activity of selenophosphocholine analogues containing tegafur].
abstract: OBJECTIVE
  To synthesize the selenophosphocholine analogues containing tegafur and test their antitumor activities.
  
  
  METHODS
  The cyclic glyceroselenophospholopid conjugate of tegafur was synthesized by the reaction of hexaethylphosphorous triamide with N1-(2-furanidyl)-N3-(hydroxyalkyl)-5-fluyorouracil and 1-O-hexadecyl glycerol as well as selenium in one-pot. Cyclic glyceroselenophospholopid conjugate of tegafur reacted with triethylamine to give title compounds.
  
  
  RESULTS
  Six new compounds have been synthesized. Their structures were confirmed by 1H NMR, 13P NMR and elemental analysis. Antitumor activity of the title compounds against PGA1 was tested.
  
  
  CONCLUSIONS
  The reaction of triethylamine with cyclic glyceroselenophospholopid conjugate of tegafur very readily occurred, which was finished within 2 h at room temperature. The opening-ring products of trans isomers showed antimutor activity against human uriaryl bladder cancer cell more effective than that of the tegafur.
authors.affiliation: College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China.
authors.forename: Zhong-Lin
authors.initials: ZL
authors.lastname: Zang
authors.forename: Shao-Qiong
authors.initials: SQ
authors.lastname: Liu
authors.forename: Xiong
authors.initials: X
authors.lastname: Chen
authors.forename: Yan-Jie
authors.initials: YJ
authors.lastname: Li
authors.forename: Bing
authors.initials: B
authors.lastname: Zhou
authors.forename: Xin-Hua
authors.initials: XH
authors.lastname: Xu
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D045744:Cell Line, Tumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D016566:Organoselenium Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D010767:Phosphorylcholine / Q000031:analogs & derivatives*; D005641:Tegafur / Q000138:chemical synthesis* / Q000494:pharmacology; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy / Q000473:pathology
chemical_list: D000970:Antineoplastic Agents; D016566:Organoselenium Compounds; D010767:Phosphorylcholine; D005641:Tegafur