title: Investigation of interactions between two monoclonal antibodies and SARS virus with a Label-free Protein Array.
abstract: The investigation of interactions between two kinds of monoclonal antibodies and SARS virus with a label-free protein array technique were presented in this paper. The performance consists of three parts: a surface modification for ligand immobilization/surface, a protein array fabrication with an integrated microfluidic system for patterning, packaging and liquid handling, and a protein array reader of imaging ellipsometer. This revealed the technique could be used as an immunoassay for qualitative and quantitative detection as well as kinetic analysis of biomolecule interaction.
authors.affiliation: Institute of Mechanics, Chinese Academy of Sciences, #15, Bei-si-huan West Rd., Beijing 100080, P.R.China; Graduate School of Chinese Academy of Sciences, #19, Yu-quan Rd, Shi-jing-shan District, Beijing 100039, P.R.China.
authors.forename: C
authors.initials: C
authors.lastname: Qi
authors.forename: Y-Y
authors.initials: YY
authors.lastname: Chen
authors.forename: Z-H
authors.initials: ZH
authors.lastname: Wang
authors.forename: G
authors.initials: G
authors.lastname: Jin