title: The influence of volume conduction effects on the EEG/MEG reconstruction of the sources of the Early Left Anterior Negativity.
abstract: To achieve a deeper understanding of language processing in the human brain, scientists and clinicians use Electroencephalography (EEG) and Magnetoencephalography (MEG) inverse methods to reconstruct sources of Event Related Potentials. There exists a persistent uncertainty regarding the influence of volume conduction effects such as the anisotropy of tissue conductivity of the skull and the white matter layers on the inverse results. In this paper, we will study the sensitivity to anisotropy of the source reconstruction of the Early Left Anterior Negativity (ELAN) component in language processing. For EEG, the presence of tissue anisotropy substantially compromises the restoration ability of an L1-norm current density approach. The centers of activity are strongly shifted along the Sylvian fissure in the anterior direction. In contrast, MEG in combination with the L1 norm approach is able to reconstruct the main features of the ELAN source distribution even in the presence of anisotropic conductivity.
authors.affiliation: Scientific Computing and Imaging Institute, University of Utah, Salt Lake City, USA.
authors.forename: C H
authors.initials: CH
authors.lastname: Wolters
authors.forename: A
authors.initials: A
authors.lastname: Anwander
authors.forename: B
authors.initials: B
authors.lastname: Maess
authors.forename: R S
authors.initials: RS
authors.lastname: Macleod
authors.forename: A D
authors.initials: AD
authors.lastname: Friederici