title: Vedaprofen therapy in cats with upper respiratory tract infection or following ovariohysterectomy.
abstract: OBJECTIVE
  The antipyretic and analgesic efficacy of vedaprofen (at a dose of 0.5 mg/kg) was evaluated after repeated once-daily administration (for three or five days) to 80 cats with upper respiratory tract disease or 302 cats undergoing ovariohysterectomy.
  
  
  METHODS
  Both clinical trials were randomised, double blinded and placebo controlled.
  
  
  RESULTS
  In the upper respiratory tract disease trial, vedaprofen produced a significant reduction in rectal temperature when compared with cats administered antimicrobial treatment only. This antipyretic activity lasted at least four hours after administration on the first day of treatment (day 0) and at least eight hours on day 1 and day 2. Significantly more cats in the treatment group were classified as having returned to normal on day 5, day 6 and day 7 compared with the placebo group. In the ovariohysterectomy trial, scores for behaviour (on day 1, day 2 and day 3) and appetite (on day 1 and day 2) were significantly better in the vedaprofen group than in the placebo-treated cats.
  
  
  CONCLUSIONS
  Vedaprofen produced a clinically relevant reduction in body temperature and a more rapid return to normality in cats with upper respiratory tract disease. Vedaprofen treatment also resulted in more rapid recovery, presumably through the relief of pain and inflammation, in cats that had undergone soft tissue surgery.
authors.affiliation: Intervet Pharma R&D, Rue Olivier de Serres - BP 67131, 49071 Beaucouzé Cedex, France.
authors.forename: S
authors.initials: S
authors.lastname: Lopez
authors.forename: S
authors.initials: S
authors.lastname: Pertuy
authors.forename: L
authors.initials: L
authors.lastname: Horspool
authors.forename: P
authors.initials: P
authors.lastname: van Laar
authors.forename: A
authors.initials: A
authors.lastname: Rutten
mesh_terms: D000284:Administration, Oral; D000700:Analgesics / Q000008:administration & dosage / Q000627:therapeutic use*; D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage / Q000627:therapeutic use*; D000818:Animals; D001831:Body Temperature; D002371:Cat Diseases / Q000188:drug therapy* / Q000473:pathology; D002415:Cats; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D005260:Female; D007044:Hysterectomy / Q000662:veterinary*; D009281:Naphthalenes / Q000008:administration & dosage / Q000627:therapeutic use*; D010147:Pain Measurement / Q000662:veterinary; D010149:Postoperative Pain / Q000517:prevention & control / Q000662:veterinary*; D011422:Propionates / Q000008:administration & dosage / Q000627:therapeutic use*; D012141:Respiratory Tract Infections / Q000188:drug therapy* / Q000473:pathology; D016896:Treatment Outcome
chemical_list: D000700:Analgesics; D018712:Analgesics, Non-Narcotic; D009281:Naphthalenes; D011422:Propionates; C121784:2-(4-cyclohexyl-1-naphthalenyl)propanoic acid