title: [HSC70 protein of human blood mononuclears as a sign of adaptation under normobaric hypoxia training].
abstract: We investigated two isoforms of heat shock protein 70 kDa: HSP70 and HSC70, in the human blood mononuclears under normobaric hypoxia training. It was shown that hypoxia regimen does not lead to manifestation of stress but exerts activation of the organism. The obtained organism adaptation is achieved with a little cost that is confirmed by absence of HSP70 content increase. HSC70 content in the blood mononuclears was increased in most case up to 1.5-2.0 fold. HSC70 displays itself as a sign of adaptation. We connect the increase of HSC70 with mitochondria biogenesis which is given a leading importance under adaptation of aerobic organism cells to hypoxia.
authors.forename: A A
authors.initials: AA
authors.lastname: Boĭkova
authors.forename: L I
authors.initials: LI
authors.lastname: Andreeva
authors.forename: B A
authors.initials: BA
authors.lastname: Margulis
mesh_terms: D000222:Adaptation, Physiological; D000328:Adult; D000693:Anaerobiosis / Q000502:physiology; D015415:Biomarkers / Q000032:analysis / Q000378:metabolism; D015444:Exercise / Q000502:physiology*; D005260:Female; D050883:HSC70 Heat-Shock Proteins / Q000032:analysis / Q000378:metabolism*; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000737:chemistry; D008297:Male; D020033:Protein Isoforms / Q000032:analysis / Q000378:metabolism
chemical_list: D015415:Biomarkers; D050883:HSC70 Heat-Shock Proteins; D020033:Protein Isoforms