title: Pycnanthuquinone C: a new terpenoid-quinone from Pycnanthus angolensis.
abstract: A new compound containing a unique terpenoid-quinone skeleton, pycnanthuquinone C (1) along with the known sargachromenol (2), prunetin (3), biochanin A (4), calopiptin (5), (12 S,13 S)-12,13-dihydroxylabda-8(17),14-dien-18-oic acid (6), (12 R,13 S)-12,13-dihydroxylabda-8(17),14-dien-18-oic acid (7), and sitosterol 3- O-beta- D-glucopyranoside (8), were isolated from the stem bark of Pycnanthus angolensis. Their structures were elucidated by spectroscopic means and comparison with published data. The antifungal activity of compounds 1, 2 and 3 was evaluated. Compound 1 was active against Trichophyton soudanense. Compound 2 was active against Trichophyton mentagrophytes while compound 3 was active against Microsporum audouinii and Trichophyton mentagrophytes.
authors.affiliation: Department of Chemistry, University of Dschang, Dschang, Cameroon.
authors.forename: Hippolyte K
authors.initials: HK
authors.lastname: Wabo
authors.forename: Simplice N
authors.initials: SN
authors.lastname: Tatsimo
authors.forename: Pierre
authors.initials: P
authors.lastname: Tane
authors.forename: Joseph D
authors.initials: JD
authors.lastname: Connolly
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008864:Microsporum / Q000187:drug effects; D026324:Myristicaceae / Q000737:chemistry*; D019906:Nuclear Magnetic Resonance, Biomolecular; D024301:Plant Bark / Q000737:chemistry; D011809:Quinones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014249:Trichophyton / Q000187:drug effects
chemical_list: D000935:Antifungal Agents; D011809:Quinones; D013729:Terpenes; C520794:pycnanthuquinone C (Pycnanthus angolensis)