Soluble adhesion molecules and angiotensin-converting enzyme in dementia.
We aimed to determine plasma and cerebrospinal fluid (CSF) levels of angiotensin-converting enzyme (ACE) and the soluble forms of intercellular adhesion molecule-1 (sICAM-1), vascular cell adhesion molecule-1 (sVCAM-1) and platelet endothelial cell adhesion molecule-1 (sPECAM-1) as surrogate markers for endothelial cell activation in clinically diagnosed patients with Alzheimer's disease (AD, n=260), dementia with Lewy bodies (DLB, n=39) and non-demented controls (n=34). Plasma sICAM-1 and sPECAM-1 were higher and CSF sVCAM-1 were lower in AD and DLB patients than in controls (p<0.001). DLB patients had higher CSF sICAM-1, but lower CSF sVCAM-1 (p<0.001). No difference in ACE levels was found between the dementia groups and controls. In controls and AD patients CSF sICAM and sVCAM-1 strongly correlated with each other and with blood barrier permeability whereas in DLB group these correlations were weaker. The observed patterns in adhesion molecules may reflect distinctions in the pathophysiological basis of their generation in dementia patients.
Nielsen
Henrietta M
HM
Chronic Inflammatory and Degenerative Disease Research Unit, Department of Clinical Sciences, Lund University, 205 02 Malmö, Sweden. henrietta.nielsen@med.lu.se
Londos
Elisabet
E
Minthon
Lennart
L
Janciauskiene
Sabina M
SM
D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology; D000483:Alleles; D000544:Alzheimer Disease / Q000201:enzymology / Q000378:metabolism; D053327:Apolipoprotein E4 / Q000235:genetics; D001794:Blood Pressure / Q000502:physiology; D001812:Blood-Brain Barrier / Q000502:physiology; D003071:Cognition / Q000502:physiology; D003704:Dementia / Q000201:enzymology / Q000378:metabolism* / Q000523:psychology; D005260:Female; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000378:metabolism; D020961:Lewy Body Disease / Q000201:enzymology / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D019006:Neural Cell Adhesion Molecules / Q000378:metabolism*; D007703:Peptidyl-Dipeptidase A / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism*; D010539:Permeability; D019408:Platelet Endothelial Cell Adhesion Molecule-1 / Q000378:metabolism; D011569:Psychiatric Status Rating Scales; D019010:Vascular Cell Adhesion Molecule-1 / Q000378:metabolism
D053327:Apolipoprotein E4; D019006:Neural Cell Adhesion Molecules; D019408:Platelet Endothelial Cell Adhesion Molecule-1; D019010:Vascular Cell Adhesion Molecule-1; D018799:Intercellular Adhesion Molecule-1; D007703:Peptidyl-Dipeptidase A