Biochemical, biomolecular and cellular sensing in microfluidics using flow induced admittance spectra.
We present flow induced admittance spectra for electrolytes, cell culture media, different sizes of DNA solutions and neural cells using flow induced admittance spectra in a microfluidics device. The device comprises of a PDMS channel aligned with a pair of channel electrodes fabricated on glass. The peak of the flow induced admittance spectra and frequency at which the peak occurs are the key parameters used for the characterization of sensing. The response of this sensor is a function of the conductivity and dielectrivity of the effective solution. The flow induced admittances of the particles studied are corrected with their media. This sensing will be a primary component of an electrical based cytometer.
Collins
J
J
Dept. of Biomed. Eng., California Univ., Irvine, CA, USA.
Flanagan
L
L
Jeon
N
N
Monuki
E
E
Lee
A P
AP