Characterization of polyether mixtures using thin-layer chromatography and matrix-assisted laser desorption/ionization mass spectrometry.
Thin-layer chromatography (TLC) and matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) were combined to achieve characterization of polyether mixtures. Three polyethers, polyethylene glycol (PEG), polypropylene glycol (PPG) and polytetramethylene glycol (PTMG), or mixtures of these compounds, were studied. One shortcoming of mixture analysis of synthetic polymers using MALDI-MS is that individual polymers in the mixture may display different detection sensitivities. For example, the MALDI mass spectrum of an equimolar mixture of PEG, PPG and PTMG displayed a high intensity of PPG ions, while no PTMG ions were detectable; however, PTMG ions were detected after the mixture had been separated by TLC. This combined TLC and MALDI-MS analysis of a PPG polymer bearing reactive epoxy groups showed that the polymer contained byproducts with different end-groups. These byproducts were identified as chloro-substituted polymers formed during polymer synthesis. Our study shows TLC to be a rapid and low-cost separation technique, and that it can be combined with MALDI-MS to achieve effective analysis of synthetic polymers.
Watanabe
Takehiro
T
Department of Applied Chemistry, Kansai University, Suita, Osaka 564-8680, Japan.
Kawasaki
Hideya
H
Kimoto
Takashi
T
Arakawa
Ryuichi
R
D002855:Chromatography, Thin Layer; D045424:Complex Mixtures / Q000737:chemistry*; D006018:Glycols / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry*; D019946:Propylene Glycol / Q000737:chemistry*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / Q000379:methods*
D045424:Complex Mixtures; D006018:Glycols; C047554:polytetramethylene glycol; D011092:Polyethylene Glycols; D019946:Propylene Glycol