title: [Influence factors on the entrapment of drugs in a novel proliposomes].
abstract: OBJECTIVE
  A new proliposomal technology was used to trap several drugs, such as tegafur, silymarin, cistanosides, oleanolic acid. And then these proliposomal characters were studied.
  
  
  METHODS
  These proliposomes formed liposomes after mixing with water. And then the liposomal morphology was determined by electron microscope, and the liposomal particle size determined by particle sizes instrument. The trap efficiency was determined by the column chromatography, and then the influence factors on the trap efficiency were investigated.
  
  
  RESULTS
  The liposomes looked round, some with multiply layers, the particle was small, and the xi potential was about - 30 mV. The trap efficiency changed with the partition coefficient and pH. When the partition coefficient and pH increased, the trap efficiency increased. Furthermore, the trap efficiency was not influenced by the molecular weight.
  
  
  CONCLUSIONS
  This kind of liposomal technology trapped the drugs efficiently, and the lipophilic drugs were trapped more easily. Some Chinese traditional drugs could be trapped too.
authors.affiliation: (Xinjiang Medical University, Urumqi 830054, China. wm630@163.com
authors.forename: Mei
authors.initials: M
authors.lastname: Wang
authors.forename: Xiao-Li
authors.initials: XL
authors.lastname: Gao
mesh_terms: D006863:Hydrogen-Ion Concentration; D008081:Liposomes / Q000737:chemistry*; D009828:Oleanolic Acid / Q000008:administration & dosage; D010316:Particle Size; D012838:Silymarin / Q000008:administration & dosage; D013678:Technology, Pharmaceutical; D005641:Tegafur / Q000008:administration & dosage
chemical_list: D008081:Liposomes; D012838:Silymarin; D005641:Tegafur; D009828:Oleanolic Acid