A Novel Remote Controlled Capsule for Human Drug Absorption studies.
Remote Controlled Capsule (RCC) is a new method to realize non-invasive drug delivery to the selected sites of human gastro-intestinal (GI) tract. With RCC, Human Drug Absorption (HDA) studies are taken easily to obtain data on the intestinal absorption of a drug in humans. In this paper, a new RCC system has been designed based on MEMS technology to provide for the delivery of a wide range of different drug formulations, for example, solution, powder and granulate, into any region of the gut. A magnetic Marker Monitoring (MMM) system was developed to monitor the location of the capsule inside the gut. A novel method to indicating the drug release, called as Indicating System based on Abrupt Movement of Marker (ISAMM), was proposed in this study. High reliability of the RCC system has been proved by animal experiments.
Xitian
Pi
P
Key lab for biomechanics & tissue engineering of the state ministry of education, Chongqing University, Chongqing city 400044, China. E-mail: pixitian@163.com.
Xiaolin
Zheng
Z
Chenglin
Peng
P
Wensheng
Hou
H
Hongying
Liu
L