title: Constructing a tissue-specific model of ventricular microstructure.
abstract: Simulations of cardiac electrical activity are generally computed in idealized or generic domains. We have developed a semi-automated technique for imaging an extended volume of cardiac ventricular tissue at a resolution of approximately 1 microm, and constructing from those images a geometric and structural model with 10 microm resolution suitable for solving the bidomain equations. This technique enables experimental modeling and computer simulation to be integrated by constructing a tissue-specific structural model in less than one week. We demonstrate the use of this procedure applied to a sample of rat ventricle.
authors.affiliation: Bioengineering Institute, The University of Auckland, New Zealand.
authors.forename: G
authors.initials: G
authors.lastname: Sands
authors.forename: M
authors.initials: M
authors.lastname: Trew
authors.forename: D
authors.initials: D
authors.lastname: Hooks
authors.forename: I
authors.initials: I
authors.lastname: Le Grice
authors.forename: A
authors.initials: A
authors.lastname: Pullan
authors.forename: B
authors.initials: B
authors.lastname: Smaill