Extracellular concentration of anticancer drugs that regulates their intracellular distribution and binding to DNA in cells with multidrug resistant phenotype.
Bogush
T A
TA
Blokhin Cancer Research Center, Russian Academy of Medical Science, Kashirskoe sh. 24, Moscow, 115478 Russia.
Ravcheeva
A B
AB
Bogush
E A
EA
Konukhova
A V
AV
Kuz'mina
K E
KE
Baryshnikov
A Y
AY
Davydov
M I
MI
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000378:metabolism; D018943:Anthracyclines / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000493:pharmacokinetics*; D002467:Cell Nucleus / Q000378:metabolism; D003593:Cytoplasm / Q000378:metabolism; D004247:DNA / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D004317:Doxorubicin / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D018432:Drug Resistance, Multiple; D006801:Humans; D020014:K562 Cells; D010641:Phenotype; D011485:Protein Binding
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D018943:Anthracyclines; D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D004317:Doxorubicin; D004247:DNA