Ascorbic acid antagonizes nicotine-induced place preference and behavioral sensitization in mice.
In the present study, the influence of ascorbic acid on the nicotine-induced behavioral sensitization and conditioned place preference was investigated in mice. In the place preference paradigm, intraperitoneal (i.p.) nicotine (1 and 1.5 mg/kg, three drug sessions) but not ascorbic acid (1, 10, 100 and 1000 mg/kg) administration induced place preference. Ascorbic acid administration (10, 100 and 1000 mg/kg, i.p.) reduced both the acquisition and expression of nicotine-induced place conditioning. Locomotor sensitization in mice was produced by intraperitoneal injection of nicotine (0.25 mg/kg) for 7 consecutive days. On the 9th day of the experiments, activity of the mice was recorded after challenge with nicotine (0.1 mg/kg, i.p.). Ascorbic acid (10, 100 and 1000 mg/kg, i.p.) was injected 20 min before each injection of nicotine (acquisition of sensitization) or acutely 20 min before a challenge nicotine injection (expression of sensitization). It was shown that ascorbic acid attenuated the acquisition of nicotine sensitization in a dose-independent manner but the expression of nicotine-induced sensitization was not affected by ascorbic acid. In conclusion, it seems that ascorbic acid may interfere with nicotine-induced place preference and behavioral sensitization in mice.
Sahraei
Hedayat
H
Department of Physiology and Biophysics and Behavioral Sciences Research Center (BSRC), Baqiyatallah (a.s.) University of Medical Sciences, Tehran, Iran. h.Sahraei@bmsu.ac.ir
Aliabadi
Ali Akbar
AA
Zarrindast
Mohammad-Reza
MR
Ghoshooni
Hassan
H
Nasiri
Ali
A
Barzegari-Sorkheh
Amir Abbas
AA
Yari
Maryam
M
Zardooz
Homeira
H
Hossein-Mardi
Leila
L
Faraji
Nasrin
N
Shams
Jamal
J
D000818:Animals; D001205:Ascorbic Acid / Q000008:administration & dosage / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects*; D003216:Conditioning, Operant / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005260:Female; D007274:Injections, Intraperitoneal; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D009538:Nicotine / Q000008:administration & dosage / Q000494:pharmacology*; D018722:Nicotinic Agonists / Q000008:administration & dosage / Q000494:pharmacology*; D014815:Vitamins / Q000008:administration & dosage / Q000494:pharmacology*
D018722:Nicotinic Agonists; D014815:Vitamins; D009538:Nicotine; D001205:Ascorbic Acid