An architectural perspective of vitamin D responsiveness.
Vitamin D serves as a principal modulator of skeletal gene transcription, thus necessitating an understanding of interfaces between the activity of this steroid hormone and regulatory cascades that are functionally linked to the regulation of skeletal genes. Physiological responsiveness requires combinatorial control where coregulatory proteins determine the specificity of biological responsiveness to physiological cues. It is becoming increasingly evident that the regulatory complexes containing the vitamin D receptor are dynamic rather than static. Temporal and spatial modifications in the composition of these complexes provide a mechanism for integrating regulatory signals to support positive or negative control through synergism and antagonism. Compartmentalization of components of vitamin D control in nuclear microenvironments supports the integration of regulatory activities, perhaps by establishing thresholds for protein activity in time frames that are consistent with the execution of regulatory signaling.
Montecino
Martin
M
Departamento de Bioquimica y Biologia Molecular, Facultad de Ciencias Biologicas, Universidad de Concepcion, Concepcion, Chile. mmonteci@udec.cl
Stein
Gary S
GS
Cruzat
Fernando
F
Marcellini
Sylvain
S
Stein
Janet L
JL
Lian
Jane B
JB
van Wijnen
Andre J
AJ
Arriagada
Gloria
G
D021581:Active Transport, Cell Nucleus / Q000502:physiology; D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism*; D005786:Gene Expression Regulation / Q000502:physiology*; D006801:Humans; D018167:Receptors, Calcitriol / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*; D014807:Vitamin D / Q000378:metabolism*
D018167:Receptors, Calcitriol; D014807:Vitamin D