title: Designing biological systems.
abstract: The design of artificial biological systems and the understanding of their natural counterparts are key objectives of the emerging discipline of synthetic biology. Toward both ends, research in synthetic biology has primarily focused on the construction of simple devices, such as transcription-based oscillators and switches. Construction of such devices should provide us with insight on the design of natural systems, indicating whether our understanding is complete or whether there are still gaps in our knowledge. Construction of simple biological systems may also lay the groundwork for the construction of more complex systems that have practical utility. To realize its full potential, biological systems design borrows from the allied fields of protein design and metabolic engineering. In this review, we describe the scientific accomplishments in this field, as well as its forays into biological part standardization and education of future biological designers.
authors.affiliation: Department of Systems Biology, Harvard Medical School, Boston, Massachusetts 02115, USA.
authors.forename: David A
authors.initials: DA
authors.lastname: Drubin
authors.forename: Jeffrey C
authors.initials: JC
authors.lastname: Way
authors.forename: Pamela A
authors.initials: PA
authors.lastname: Silver
mesh_terms: D000818:Animals; D002450:Cell Communication; D005818:Genetic Engineering / Q000379:methods* / Q000639:trends; D006801:Humans; D053858:Metabolic Networks and Pathways; D008954:Models, Biological; D012107:Research Design; D015398:Signal Transduction