Epoxygenase eicosanoids: synthesis of tetrahydrofuran-diol metabolites and their vasoactivity.
Eight members of a recently identified family of tetrahydrofuran-diols (THFDs), originating from epoxyeicosatrienoic acids (EETs), were prepared stereospecifically from D-(+)-glucose. The THFDs potently induced relaxation of pre-contracted bovine arteries.
Falck
J R
JR
Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. j.falck@UTSouthwestern.edu
Reddy
L Manmohan
LM
Byun
Kihwan
K
Campbell
William B
WB
Yi
Xiu-Yu
XY
D000818:Animals; D001158:Arteries / Q000187:drug effects*; D002417:Cattle; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D004305:Dose-Response Relationship, Drug; D015195:Drug Design; D015777:Eicosanoids / Q000138:chemical synthesis* / Q000494:pharmacology*; D005663:Furans / Q000737:chemistry*; D008956:Models, Chemical; D008968:Molecular Conformation; D010105:Oxygenases / Q000737:chemistry*; D013237:Stereoisomerism; D014664:Vasodilation / Q000187:drug effects; D014665:Vasodilator Agents / Q000138:chemical synthesis* / Q000494:pharmacology*
D015777:Eicosanoids; D005663:Furans; D014665:Vasodilator Agents; C018674:tetrahydrofuran; D010105:Oxygenases