Late stent thrombosis after transcoronary transplantation of granulocyte-colony stimulating factor-mobilized peripheral blood stem cells following primary percutaneous intervention for acute myocardial infarction.
Transcoronary transplantation of autologous stem cells (ASC) can improve cardiac function after myocardial infarction. For ASC-propagation, granulocyte-colony stimulating factor (G-CSF) is widely used. However, a clinical long-term safety profile of combining G-CSF therapy and transcoronary ASC-transplantation does not exist. We report on three cases of late stent thrombosis in a cohort of 24 patients who had undergone intracoronary infusion of G-CSF-mobilized ASC after primary stenting for acute myocardial infarction.
Steinwender
Clemens
C
Hofmann
Robert
R
Kypta
Alexander
A
Gabriel
Christian
C
Leisch
Franz
F
D003328:Coronary Thrombosis / Q000175:diagnosis* / Q000209:etiology; D005260:Female; D005500:Follow-Up Studies; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage*; D019650:Hematopoietic Stem Cell Mobilization; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications / Q000628:therapy*; D015607:Stents / Q000009:adverse effects*; D013997:Time Factors
D016179:Granulocyte Colony-Stimulating Factor