Evaluation of STOX1 as a preeclampsia candidate gene in a population-wide sample.
Preeclampsia is a common, pregnancy-specific vascular disorder characterised by hypertension and proteinuria. A recent report suggested association of the STOX1 gene on chromosome 10q22.1 with preeclampsia in the Dutch population. Here, we present a comprehensive assessment of STOX1 as a candidate gene for preeclampsia in the Finnish population by re-examining our previous genetic linkage analysis results for both chromosome 10 and paralogous loci, by genotyping representative markers in a nationwide data set, and by studying STOX1 expression in placentas from preeclamptic and uncomplicated pregnancies. In conclusion, we are unable to validate STOX1 as a common preeclampsia susceptibility gene.
Kivinen
Katja
K
Department of Biosciences at Novum, Karolinska Institutet, Stockholm, Sweden.
Peterson
Hanna
H
Hiltunen
Leena
L
Laivuori
Hannele
H
Heino
Sanna
S
Tiala
Inkeri
I
Knuutila
Sakari
S
Rasi
Vesa
V
Kere
Juha
J
D000818:Animals; D002352:Carrier Proteins / Q000235:genetics*; D015331:Cohort Studies; D005260:Female; D005387:Finland; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D014644:Genetic Variation; D006239:Haplotypes / Q000235:genetics*; D006801:Humans; D008126:Lod Score; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods; D010920:Placenta / Q000737:chemistry / Q000502:physiology; D044382:Population Groups / Q000235:genetics*; D011225:Pre-Eclampsia / Q000175:diagnosis / Q000235:genetics*; D011247:Pregnancy; D012313:RNA / Q000235:genetics / Q000302:isolation & purification; D017422:Sequence Analysis, DNA
D002352:Carrier Proteins; D005819:Genetic Markers; C500784:STOX1 protein, human; D012313:RNA