Liver transplantation in HIV-HCV coinfected patients: a case-control study.
Liver transplantation (LT) for hepatitis C virus (HCV)-associated cirrhosis in human immunodeficiency virus (HIV)-infected patients was compared with non-HIV patients. Nine patients with HIV-HCV coinfection were compared with patients transplanted before and after each HIV patient (control group). Immunosuppression consisted in tacrolimus with steroids or mycophenolate mofetil. Acute cellular rejection and three-year actuarial patient survival were respectively 44% and 87.5% in HIV group and 22% and 93.7% in the control group (P=NS). Acute hepatitis C virus occurred earlier (2.3 vs. 4.3 months) and was more cholestatic (mean bilirubin: 10.8 vs. 1.6 mg/dL) in the HIV group. Eight (100%) HIV and nine (64.3%) control patients received antiviral treatment with pegylated interferon and ribavirin. One patient (11.1%) of the control group and one patient (20%) of the HIV group presented a sustained virologic response (P=NS). Short- to midterm results of LT in HIV-HCV co-infected patients were excellent and similar to non-HIV patients.
Castells
Lluis
L
Liver Unit, Department of Internal Medicine, Hospital Universitari Vall d'Hebrón, Universidad Autónoma de Barcelona, Barcelona, Spain.
Escartín
Alfredo
A
Bilbao
Itxarone
I
Len
Oscar
O
Allende
Helena
H
Vargas
Víctor
V
Ribera
Esteban
E
Lázaro
José-Luis
JL
Bueno
Javier
J
Balsells
Joaquin
J
Esteban
Rafael
R
Pahissa
Albert
A
Margarit
Carlos
C
D000328:Adult; D000368:Aged; D000998:Antiviral Agents / Q000627:therapeutic use; D016022:Case-Control Studies; D005260:Female; D015658:HIV Infections / Q000150:complications*; D019698:Hepatitis C, Chronic / Q000150:complications* / Q000517:prevention & control / Q000601:surgery*; D006801:Humans; D007165:Immunosuppression Therapy; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D009173:Mycophenolic Acid / Q000031:analogs & derivatives / Q000627:therapeutic use; D013256:Steroids / Q000627:therapeutic use; D016559:Tacrolimus / Q000627:therapeutic use; D016896:Treatment Outcome
D000998:Antiviral Agents; D013256:Steroids; D009173:Mycophenolic Acid; D016559:Tacrolimus