Evaluation of nitroalkenes as nitric oxide donors.
Chemiluminescence experiments demonstrate that simple nitroalkenes release low levels of nitric oxide. UV and EPR measurements suggest but cannot confirm direct NO release from nitroalkenes. Given the biological activity of nitrated unsaturated fatty acids, these results suggest the possible metabolic conversion of nitroalkenes to NO.
Gorczynski
Michael J
MJ
Department of Chemistry, Wake Forest University, Winston-Salem, NC 27109, USA.
Huang
Jinming
J
Lee
Heather
H
King
S Bruce
SB
D000475:Alkenes / Q000138:chemical synthesis* / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D004305:Dose-Response Relationship, Drug; D015195:Drug Design; D004578:Electron Spin Resonance Spectroscopy; D049449:Luminescence; D008956:Models, Chemical; D008968:Molecular Conformation; D009569:Nitric Oxide / Q000737:chemistry; D020030:Nitric Oxide Donors; D009574:Nitro Compounds / Q000737:chemistry; D013056:Spectrophotometry, Ultraviolet; D013997:Time Factors
D000475:Alkenes; D020030:Nitric Oxide Donors; D009574:Nitro Compounds; D009569:Nitric Oxide