title: A modeling paradigm incorporating parametric and non-parametric methods.
abstract: A novel parametric/non-parametric modeling paradigm was defined and used in characterization of synaptic transmission. In this paradigm, parametric and nonparametric techniques were incorporated in a complementary manner. Non-parametric method was used to generalize experimental data and extract system input/output properties. It provided a quantitative and intuitive way to validate a parametric model with respect to general, complete input patterns. Biological processes or mechanisms missed by the conventional parametric modeling approach were revealed and subsequently included into the modified parametric model.
authors.affiliation: Dept. of Biomedical Eng., Southern California Univ., Los Angeles, CA, USA.
authors.forename: D
authors.initials: D
authors.lastname: Song
authors.forename: Z
authors.initials: Z
authors.lastname: Wang
authors.forename: V Z
authors.initials: VZ
authors.lastname: Marmarelis
authors.forename: T W
authors.initials: TW
authors.lastname: Berger