title: Intracranial polyps in patients with Samter's triad.
abstract: BACKGROUND
  We describe three patients with Samter's triad (nasal polyps, aspirin intolerance, and asthma) with skull base dehiscence in whom the polyps extended into the extradural space and also resulted in hypertelorism and widening of the nasal bridge.
  
  
  METHODS
  One patient died in a road traffic accident while awaiting surgery. The other two patients underwent endoscopic resection of the polyps with a combined osteoplastic flap.
  
  
  RESULTS
  Histology confirmed benign eosinophilic polyps with edematous stroma and a markedly thickened basement membrane. There were no complications or revision procedures. Both are symptomatically well with improvement of the hypertelorism.
  
  
  CONCLUSIONS
  These cases indicate that polyps in Samter's triad may be extremely aggressive, resulting in intracranial extension. A combined endoscopic and osteoplastic flap approach is a safe and effective surgical option.
authors.affiliation: Department of Otorhinolaryngology, Charing Cross Hospital, Fulham Palace Road, London, United Kingdom. anoojmajithia@hotmail.com
authors.forename: Anooj
authors.initials: A
authors.lastname: Majithia
authors.forename: Taran
authors.initials: T
authors.lastname: Tatla
authors.forename: Gurpreet
authors.initials: G
authors.lastname: Sandhu
authors.forename: Hesham A
authors.initials: HA
authors.lastname: Saleh
authors.forename: Hesham M
authors.initials: HM
authors.lastname: Saleh
authors.forename: Peter M
authors.initials: PM
authors.lastname: Clarke
mesh_terms: D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D001241:Aspirin / Q000009:adverse effects*; D001249:Asthma / Q000150:complications*; D003937:Diagnosis, Differential; D004342:Drug Hypersensitivity / Q000150:complications*; D004724:Endoscopy; D005626:Frontal Sinus / Q000000981:diagnostic imaging* / Q000601:surgery; D006801:Humans; D008297:Male; D009298:Nasal Polyps / Q000150:complications* / Q000000981:diagnostic imaging / Q000601:surgery; D013577:Syndrome; D014057:Tomography, X-Ray Computed
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D001241:Aspirin