The genome of non-O1 Vibrio cholerae NRT36S demonstrates the presence of pathogenic mechanisms that are distinct from those of O1 Vibrio cholerae.
Vibrio cholerae NRT36S is a non-cholera toxin-producing, non-O1 strain that causes diarrhea in volunteers. The genome of NRT36S was sequenced to create a draft containing 174 contigs plus the superintegron region. Our analysis of the draft genome revealed several putative toxin genes and colonization factors. Besides confirming the existence of nonagglutinable heat-stable toxin, we also identified the genes for a type three secretion system, a putative exotoxin, two different RTX toxins, and four pilus systems.
Chen
Yuansha
Y
University of Maryland, Howard Hall 585, 660 W. Redwood Street, Baltimore, MD 21201, USA.
Johnson
Judith A
JA
Pusch
Gordon D
GD
Morris
J Glenn
JG
Stine
O Colin
OC
D001426:Bacterial Proteins / Q000235:genetics*; D003967:Diarrhea / Q000382:microbiology / Q000473:pathology; D014644:Genetic Variation; D016680:Genome, Bacterial; D006801:Humans; D008969:Molecular Sequence Data; D017422:Sequence Analysis, DNA; D013045:Species Specificity; D014735:Vibrio Infections / Q000382:microbiology / Q000473:pathology; D041241:Vibrio cholerae O1 / Q000145:classification / Q000235:genetics / Q000472:pathogenicity*; D044163:Vibrio cholerae non-O1 / Q000145:classification / Q000235:genetics / Q000472:pathogenicity*
D001426:Bacterial Proteins