title: Concise, enantioselective total synthesis of (-)-alstonerine.
abstract: A novel enantioselective total synthesis of (-)-alstonerine has been completed that requires only 15 steps from L-tryptophan. The synthesis features the first application of a Pauson-Khand reaction to synthesize an azabridged bicyclic skeleton. [reaction: see text]
authors.affiliation: Department of Chemistry and Biochemistry, The University of Texas at Austin, Austin, TX 78712, USA.
authors.forename: Kenneth A
authors.initials: KA
authors.lastname: Miller
authors.forename: Stephen F
authors.initials: SF
authors.lastname: Martin
mesh_terms: D000470:Alkaloids / Q000138:chemical synthesis*; D001372:Aza Compounds / Q000737:chemistry; D001643:Bridged Bicyclo Compounds / Q000737:chemistry; D026121:Indole Alkaloids / Q000138:chemical synthesis*; D008956:Models, Chemical; D013237:Stereoisomerism; D014364:Tryptophan / Q000737:chemistry
chemical_list: D000470:Alkaloids; D001372:Aza Compounds; D001643:Bridged Bicyclo Compounds; D026121:Indole Alkaloids; C510442:alstonerine; D014364:Tryptophan