Circulating human monocytes in the acute coronary syndrome express a characteristic proteomic profile.
We examined the proteome of circulating monocytes of patients with acute coronary syndrome at different times in comparison to that of patients with stable coronary artery disease. On admission, the expression of 18 spot proteins was altered, 10 of which were totally absent. This pattern changed progressively, and at 6 months, there were no differences with the monocyte proteome of stable patients.
Barderas
María G
MG
Department of Immunology, Fundación Jiménez Díaz, Avenida Reyes Católicos 2, 28040 Madrid, Spain.
Tuñón
José
J
Dardé
Verónica M
VM
De la Cuesta
Fernando
F
Durán
María C
MC
Jiménez-Nácher
José J
JJ
Tarín
Nieves
N
López-Bescós
Lorenzo
L
Egido
Jesús
J
Vivanco
Fernando
F
D000368:Aged; D001798:Blood Proteins / Q000378:metabolism*; D017023:Coronary Angiography; D003327:Coronary Disease / Q000097:blood* / Q000000981:diagnostic imaging; D004798:Enzymes / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000473:pathology*; D018579:Patient Selection; D040901:Proteomics / Q000379:methods*; D021241:Spectrometry, Mass, Electrospray Ionization; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
D001798:Blood Proteins; D004798:Enzymes