Characterization of a novel HLA-DRB1*04 allele (DRB1*0460) in the Italian population.
We report the identification of a novel HLA-DRB1*04, officially named DRB1*0460. It was detected during performing HLA-DRB1 high resolution typing by DNA sequencing-based method. The exon 2 nucleotide sequence of DRB1*0460 is identical to that of DRB1*040301 except at codon 63 (AGC-->AAC), changing the encoded serine to asparagine.
Frison
S
S
Dipartimento di Medicina Rigenerativa, Immunologia dei Trapianti di Organi e Tessuti, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli, Regina Elena, Via Francesco Sforza 35, 20122 Milan, Italy.
Rinaldini
C
C
Pagoda
M
M
Brambilla
C
C
Poli
F
F
D000483:Alleles; D001483:Base Sequence; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006801:Humans; D007558:Italy; D008969:Molecular Sequence Data; D011153:Population / Q000235:genetics; D044465:White People / Q000235:genetics
D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; C519203:HLA-DRB1*04:60 antigen