title: [Formulation and process optimization of formula Qiqi pellets prepared by extrusion-spheronization].
abstract: OBJECTIVE
  To prepare traditional Chinese medicine formula Qiqi pellets by extrusion-spheronization and study the optimal formulation and process.
  
  
  METHODS
  Qiqi pellets were prepared by a new style extrusion-spheronization equipment, the optimal formulation and process was obtained by the studies of influenitial factors and L9 (3(4)) orthogonal design, the micromeritic properties and product yield of pellets were determined.
  
  
  RESULTS
  The formula Qiqi pellets prepared by extrusion-spheronization were all spheral with smooth surface; the product yield was high.
  
  
  CONCLUSIONS
  Extrusion-spheronization was suitable to produce Chinese Herbal Medicine pellets. The preparation process was simple and feasible; The quality of the prepared pellets was excellent. It was worth further study.
authors.affiliation: School of Pharmacy, Jiangsu University, Zhenjiang 212001, China. chhx2005@sohu.com
authors.forename: Hong-xia
authors.initials: HX
authors.lastname: Chen
authors.forename: Xiao-bin
authors.initials: XB
authors.lastname: Jia
authors.forename: Yan
authors.initials: Y
authors.lastname: Chen
authors.forename: Guo-liang
authors.initials: GL
authors.lastname: Pan
authors.forename: Xu-dong
authors.initials: XD
authors.lastname: Cheng
mesh_terms: D027885:Astragalus propinquus / Q000737:chemistry; D002482:Cellulose / Q000737:chemistry; D004338:Drug Combinations; D004339:Drug Compounding / Q000295:instrumentation / Q000379:methods; D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000302:isolation & purification; D000431:Ethanol / Q000737:chemistry; D032305:Lycium / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D013678:Technology, Pharmaceutical / Q000295:instrumentation / Q000379:methods*; D014867:Water / Q000737:chemistry
chemical_list: D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; C528246:qiqi; D014867:Water; D000431:Ethanol; D002482:Cellulose; C109691:microcrystalline cellulose