title: Efficient h/d exchange reactions of alkyl-substituted benzene derivatives by means of the Pd/C-H(2)-D(2)O system.
abstract: A method for efficient and extensive H/D exchange of substituted benzene derivatives which is catalyzed by heterogeneous Pd/C in D(2)O as a deuterium source under hydrogen atmosphere is described. Multi-deuterium incorporation into unactivated linear or branched alkyl chains that bear a carboxyl, hydroxyl, ether, ester, or amide moiety and are connected with a benzene ring was achieved by using the Pd/C-H(2)-D(2)O system. The present method does not require expensive deuterium gas or any special equipment.
authors.affiliation: Laboratory of Medicinal Chemistry, Gifu Pharmaceutical University, Mitahora-higashi 5-6-1, Gifu 502-8585, Japan.
authors.forename: Hiroyoshi
authors.initials: H
authors.lastname: Esaki
authors.forename: Fumiyo
authors.initials: F
authors.lastname: Aoki
authors.forename: Miho
authors.initials: M
authors.lastname: Umemura
authors.forename: Masatsugu
authors.initials: M
authors.lastname: Kato
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Maegawa
authors.forename: Yasunari
authors.initials: Y
authors.lastname: Monguchi
authors.forename: Hironao
authors.initials: H
authors.lastname: Sajiki
mesh_terms: D001555:Benzene Derivatives / Q000737:chemistry*; D017666:Deuterium Oxide / Q000737:chemistry*; D006859:Hydrogen / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D010165:Palladium / Q000737:chemistry*
chemical_list: D001555:Benzene Derivatives; D010165:Palladium; D006859:Hydrogen; D017666:Deuterium Oxide