A CMOS optical/potential image sensor with 7.5&#956;m pixel size for on-chip neural and DNA spot sensing.
An optical/potential CMOS image sensor was designed and fabricated for bioimaging applications. The image sensor is capable to simultaneously sense an optical image and an on-chip potential image. Target applications of the sensor are on-chip (optical + potential) neural imaging and on-chip DNA microarray sensing. The sensor has a QCIF (176 &#215; 144) pixel array with alternatively aligned optical/potential sensing pixels. The pixel size is 7.5 &#956;m &#215; 7.5 &#956;m. The potential resolution is confirmed to be better than 10 mV. An on-chip fluorescence imaging of a mouse's hippocampus was performed to demonstrate that fluorescence imaging is possible with on-chip configuration.
Tokuda
Takashi
T
Graduate School of Materials Science, Nara Institute of Science and Technology, Nara, Japan.
Ng
David
D
Yamamoto
Akio
A
Kagawa
Keiichiro
K
Nunoshita
Masahiro
M
Ohta
Jun
J