title: [Radiation optic neuropathy after the brachytherapy of the uveal melanoma].
abstract: OBJECTIVE
  The evaluate the frequency of radiation of the optic neuropathy (RON) and its influence on visual acuity in patients with choroidal melanoma treated by brachytherapy.
  
  
  METHODS
  We analyzed 583 patients with choroidal melanoma, treated with ruthenium (106Ru) or iodine (125I) plaques in Ophthalmology Department of Jagiellonian University, between 1996 and 2004 year. The frequency of RON, its influence on loss of vision, according to a kind of the used isotope, tumor size and location were analyzed. Diagnosis of RON was established on the base of characteristic symptoms in the eye fundus.
  
  
  RESULTS
  The frequency of RON was significantly higher in cases treated by 125I vs 106Ru (14% vs 8.2%, p = 0.0014), in cases of tumors located in the posterior pole (31.3%, p = 0.012), and in cases of tumor thickness 3-8 mm (27.5%, p = 0.033). In most of patients we observed major deterioration of visual acuity.
  
  
  CONCLUSIONS
  The radiation of the optic neuropathy was seen often after iodine BT, tumors located in the posterior pole of fundus, with thickness 3-8 mm.
authors.affiliation: Katedry i Kliniki Okulistyki, Collegium Medicum Uniwersytetu Jagiellońskiego w Krakowie.
authors.forename: Iwona
authors.initials: I
authors.lastname: Szuścik
authors.forename: Bozena
authors.initials: B
authors.lastname: Romanowska-Dixon
authors.forename: Anna
authors.initials: A
authors.lastname: Markiewicz
authors.forename: Arkadiusz
authors.initials: A
authors.lastname: Pogrzebielski
authors.forename: Barbara
authors.initials: B
authors.lastname: Jakubowska
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001918:Brachytherapy / Q000009:adverse effects*; D002830:Choroid Neoplasms / Q000532:radiotherapy*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use; D008297:Male; D008545:Melanoma / Q000532:radiotherapy*; D008875:Middle Aged; D009900:Optic Nerve / Q000473:pathology / Q000528:radiation effects*; D009901:Optic Nerve Diseases / Q000209:etiology*; D011832:Radiation Injuries / Q000209:etiology* / Q000473:pathology; D012189:Retrospective Studies; D012429:Ruthenium Radioisotopes / Q000627:therapeutic use; D016896:Treatment Outcome; D014792:Visual Acuity / Q000528:radiation effects
chemical_list: D007457:Iodine Radioisotopes; D012429:Ruthenium Radioisotopes