title: Coexistent psoriasis and lupus erythematosus treated with alefacept.
abstract: Coexistence of psoriasis and subacute cutaneous lupus erythematosus (SCLE) is unusual. Although there have been reports of this occurrence, there have been no reports of this overlap syndrome treated with immunomodulators. We describe a case of coexisting psoriasis and SCLE initially treated with infliximab, and then alefacept. The patient's arthritis flared after the second infusion of infliximab, which was discontinued. During treatment with alefacept, the patient's psoriasis improved markedly without exacerbation of his photosensitive SCLE lesions.
authors.affiliation: Department of Internal Medicine, University of Texas Houston Health Science Center, Houston, TX, USA.
authors.forename: Cindy
authors.initials: C
authors.lastname: Berthelot
authors.forename: Jason
authors.initials: J
authors.lastname: Nash
authors.forename: Madeleine
authors.initials: M
authors.lastname: Duvic
mesh_terms: D000328:Adult; D000077944:Alefacept; D000911:Antibodies, Monoclonal / Q000009:adverse effects / Q000627:therapeutic use; D003879:Dermatologic Agents / Q000627:therapeutic use*; D006801:Humans; D000069285:Infliximab; D008178:Lupus Erythematosus, Cutaneous / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy*; D008297:Male; D011565:Psoriasis / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy*; D011993:Recombinant Fusion Proteins / Q000627:therapeutic use*; D012867:Skin / Q000473:pathology; D016896:Treatment Outcome
chemical_list: D000911:Antibodies, Monoclonal; D003879:Dermatologic Agents; D011993:Recombinant Fusion Proteins; D000069285:Infliximab; D000077944:Alefacept