title: Predisposing factors of restless legs syndrome in pregnancy.
abstract: The occurrence of restless legs syndrome in pregnancy is well known. However, the mechanism of this association is unclear. In this study, we aimed to identify the factors that predispose women to have restless legs syndrome during pregnancy. A total of 146 pregnant women were included in the study. Patients were asked questions regarding demographic characteristics, complications of pregnancy, medical therapy (vitamin and iron intake), sleep disorders, muscle cramps, and excessive daytime sleepiness. Electroneurography, routine blood biochemistry tests, complete blood count, and thyroid function tests were performed and vitamin B12, folic acid, serum iron, iron-binding capacity, ferritin, iron saturation, prolactin, estradiol, and progesterone were measured. Of the participants, 38 were diagnosed as having restless legs syndrome. In women with restless legs syndrome, additional medical problems, night cramps, and excessive daytime sleepiness were more frequent. In women without restless legs syndrome, serum hemoglobin levels were significantly higher and the use of supplemental iron or vitamins was greater. Among the women with restless legs syndrome, progesterone levels were slightly higher but this difference was not statistically significant. In summary, in this study, lower hemoglobin levels and supplementation deficits of iron and vitamins were found be the risk factors for restless legs syndrome in pregnancy.
authors.affiliation: Department of Neurology, Ankara Research and Training Hospital, Ministry of Health, Ankara, Turkey. tugbatunc@yahoo.com
authors.forename: Tuğba
authors.initials: T
authors.lastname: Tunç
authors.forename: Yeşim Sücüllü
authors.initials: YS
authors.lastname: Karadağ
authors.forename: Funda
authors.initials: F
authors.lastname: Doğulu
authors.forename: Levent E
authors.initials: LE
authors.lastname: Inan
mesh_terms: D000328:Adult; D018798:Anemia, Iron-Deficiency / Q000150:complications / Q000503:physiopathology; D004958:Estradiol / Q000097:blood; D005260:Female; D005293:Ferritins / Q000097:blood; D005492:Folic Acid / Q000097:blood; D006452:Hemoglobinometry; D006801:Humans; D007501:Iron / Q000097:blood; D033862:Iron-Binding Proteins / Q000097:blood; D011247:Pregnancy; D011248:Pregnancy Complications / Q000209:etiology* / Q000503:physiopathology; D011374:Progesterone / Q000097:blood; D011388:Prolactin / Q000097:blood; D012148:Restless Legs Syndrome / Q000209:etiology* / Q000503:physiopathology; D012307:Risk Factors; D013960:Thyroid Function Tests; D014805:Vitamin B 12 / Q000097:blood
chemical_list: D033862:Iron-Binding Proteins; D011374:Progesterone; D004958:Estradiol; D011388:Prolactin; D005293:Ferritins; D005492:Folic Acid; D007501:Iron; D014805:Vitamin B 12