title: What is the role of Toll-like receptors in bacterial infections?
abstract: Innate immunity relies on signalling by Toll-like receptors (TLRs) to alert the immune system of the presence of invading bacteria. TLR activation leads to the release of cytokines that allow for effective innate and adaptive immune responses. However, the contribution of different TLRs depends on the site of the infection and the pathogen. This review will describe the involvement of TLRs in the development of three different bacterial infections as well as our current understanding of the role of TLRs during microbial pathogenesis.
authors.affiliation: Department of Cellular Microbiology, Max Planck Institute for Infection Biology, Berlin, Germany. gerold@mpiib-berlin.mpg.de
authors.forename: Gisa
authors.initials: G
authors.lastname: Gerold
authors.forename: Arturo
authors.initials: A
authors.lastname: Zychlinsky
authors.forename: Juana L
authors.initials: JL
authors.lastname: de Diego
mesh_terms: D000818:Animals; D001424:Bacterial Infections / Q000276:immunology / Q000503:physiopathology; D006801:Humans; D012480:Salmonella Infections / Q000503:physiopathology; D013203:Staphylococcal Infections / Q000503:physiopathology; D051193:Toll-Like Receptors / Q000502:physiology*; D014376:Tuberculosis / Q000503:physiopathology
chemical_list: D051193:Toll-Like Receptors