[Effect of mucosal protective on the quality of gastric ulcer healing].
To explore the mucosal protective effect on the quality of gastric ulcer healing.



Gastric ulcers were induced in male rats by serosal application of acetic acid. Rats were gavaged for 14 days with saline, omeprazole (OME), teprenone (TEP) and TEP plus OME starting 3 days after ulcer induction. Then the tissues and blood samples were obtained and measured.



The lower ulcer index (UI) and increased ulcer inhibition rate were observed in OME and OME+TEP groups. In TEP and OME+TEP groups, restored mucosa thickness increased, cystically dilated glands decreased, microvessels in connective tissue increased, the secretion of mucus, hexosamine, PGE(2), bFGF were enhanced, the expression of EGFR was increased.



TEP can improve the quality of gastric ulcer healing, when combined with OME,the effect is more marked.
Qian
Yun
Y
Gastroenterology Laboratory, Sir Run Run Shaw Clinic Medical Research Institution, College of Medicine, Zhejiang University, Hangzhou 310016, China.
Si
Jian-Min
JM
Wu
Jia-Guo
JG
Chen
Shu-Jie
SJ
Zhu
You-Fa
YF
Sun
Ke-Ke
KK
Deng
Yan-Yong
YY
Chen
Kuang
K
Wang
Liang-Jing
LJ
Liu
Wei-Li
WL
D019342:Acetic Acid; D000818:Animals; D000897:Anti-Ulcer Agents / Q000627:therapeutic use; D004224:Diterpenes / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D066246:ErbB Receptors / Q000096:biosynthesis; D005753:Gastric Mucosa / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008297:Male; D009853:Omeprazole / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D055502:Secondary Prevention; D013276:Stomach Ulcer / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D014945:Wound Healing / Q000187:drug effects
D000897:Anti-Ulcer Agents; D004224:Diterpenes; C512478:EGFR protein, human; D066246:ErbB Receptors; D009853:Omeprazole; D019342:Acetic Acid; C031049:geranylgeranylacetone