Dopamine D3 receptor ligands: recent advances in the control of subtype selectivity and intrinsic activity.
Various pharmacological studies have implicated the dopamine D(3) receptor as an interesting therapeutic target in the treatment of different neurological disorders. Because of these putative therapeutic applications, D(3) receptor ligands with diverse intrinsic activities have been an active field of research in recent years. Separation of purely D(3)-mediated drug effects from effects produced by interactions with similar biogenic amine receptors allows to verify the therapeutic impact of D(3) receptors and to reduce possible side-effects caused by "promiscuous" receptor interactions. The requirement to gain control of receptor selectivity and in particular subtype selectivity has been a challenging task in rational drug discovery for quite a few years. In this review, recently developed structural classes of D(3) ligands are discussed, which cover a broad spectrum of intrinsic activities and show interesting selectivities.
Boeckler
Frank
F
Department of Medicinal Chemistry, Emil Fischer Center, Friedrich-Alexander University Erlangen-Nürnberg, Schuhstrasse 19, 91052 Erlangen, Germany. fmb@mrc-lmb.cam.ac.uk
Gmeiner
Peter
P
D000595:Amino Acid Sequence; D006801:Humans; D008024:Ligands; D008969:Molecular Sequence Data; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D011487:Protein Conformation; D050637:Receptors, Dopamine D3 / Q000819:agonists* / Q000037:antagonists & inhibitors / Q000737:chemistry*; D013329:Structure-Activity Relationship
D008024:Ligands; D004364:Pharmaceutical Preparations; D050637:Receptors, Dopamine D3