title: Inhibition of infection caused by severe acute respiratory syndrome-associated coronavirus by equine neutralizing antibody in aged mice.
abstract: The high susceptibility of elderly to severe acute respiratory syndrome-associated coronavirus (SARS-CoV) indicates how crucial it is to protect the elderly by various strategies. Aged BALB/c mice displayed a high susceptibility to SARS-CoV and have been a valuable platform for evaluation of strategies against SARS-CoV infection. In this study, we confirmed the validity of this model using various methods, and verified that equine anti-SARS-CoV F(ab')(2) can prevent aged animals from SARS-CoV infection. In a therapeutic setting, treatment with anti-SARS-CoV F(ab')(2) decreased viral load more than several thousand folds in the lungs. Thus, this antibody should be a potential candidate for treatment of elderly patients suffering from SARS.
authors.affiliation: Department of Immunology, Institute of Microbiology Epidemiology, Academy of Military Medical Sciences, Beijing 100071, China.
authors.forename: Lili
authors.initials: L
authors.lastname: Zhou
authors.forename: Bing
authors.initials: B
authors.lastname: Ni
authors.forename: Deyan
authors.initials: D
authors.lastname: Luo
authors.forename: Guangyu
authors.initials: G
authors.lastname: Zhao
authors.forename: Zhengcai
authors.initials: Z
authors.lastname: Jia
authors.forename: Liangyan
authors.initials: L
authors.lastname: Zhang
authors.forename: Zhihua
authors.initials: Z
authors.lastname: Lin
authors.forename: Li
authors.initials: L
authors.lastname: Wang
authors.forename: Songle
authors.initials: S
authors.lastname: Zhang
authors.forename: Li
authors.initials: L
authors.lastname: Xing
authors.forename: Jintao
authors.initials: J
authors.lastname: Li
authors.forename: Yunfei
authors.initials: Y
authors.lastname: Liang
authors.forename: Xinfu
authors.initials: X
authors.lastname: Shi
authors.forename: Tingting
authors.initials: T
authors.lastname: Zhao
authors.forename: Liyun
authors.initials: L
authors.lastname: Zhou
authors.forename: Yuzhang
authors.initials: Y
authors.lastname: Wu
authors.forename: Xiliang
authors.initials: X
authors.lastname: Wang
mesh_terms: D000375:Aging; D000818:Animals; D000914:Antibodies, Viral / Q000276:immunology*; D003588:Cytopathogenic Effect, Viral; D004195:Disease Models, Animal; D006736:Horses; D007140:Immunoglobulin Fab Fragments / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D045473:Severe acute respiratory syndrome-related coronavirus / Q000276:immunology*; D045169:Severe Acute Respiratory Syndrome / Q000473:pathology / Q000517:prevention & control*
chemical_list: D000914:Antibodies, Viral; D007140:Immunoglobulin Fab Fragments