Cardiac parametric variations in post-ischemic myocardium.
Mechanisms governing post-ischemic ventricular function after episodes of acute myocardial ischemia are still unclear. We investigated this stunned myocardial function with a computer model in conjunction with animal experiments. A modified lumped cardiac muscle model was subjected to parametric changes similar to regionally recorded ventricular parameters. The model was perturbed by alterations in contractility and rates of activation and deactivation. Results show that the cardiac muscle model can mimic many of the physiological changes observed in a stunned myocardium.
Li
John K-J
JK
Cardiovascular Engineering Labs, Dept. of Biomedical Engineering, Rutgers University, Piscataway, NJ 08854, USA.
Zhu
Ying
Y
Khaw
Kenneth
K
Kedem
Joseph
J