Human T lymphotropic virus type 1 (HTLV-1) proviral load in asymptomatic carriers, HTLV-1-associated myelopathy/tropical spastic paraparesis, and other neurological abnormalities associated with HTLV-1 infection.
Recent reports have demonstrated that human T lymphotropic virus type 1 (HTLV-1) is associated with other neurological abnormalities in addition to HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). It has been well established that high HTLV-1 proviral loads are associated with the development of HAM/TSP. We now demonstrate, for the first time, to our knowledge, that HTLV-1 proviral loads in patients with other neurological abnormalities are also significantly higher than in asymptomatic HTLV-1 carriers.
Silva
Marcus Tulius T
MT
Reference Center for Neuroinfection Diseases and HTLV, Instituto de Pesquisa Clínica Evandro Chagas, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.
Harab
Ramza Cabral
RC
Leite
Ana Cláudia
AC
Schor
Doris
D
Araújo
Abelardo
A
Andrada-Serpa
Maria José
MJ
D001938:Brazil; D002353:Carrier State; D020805:Central Nervous System Viral Diseases / Q000821:virology*; D005260:Female; D015368:Human T-lymphotropic virus 1 / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015493:Paraparesis, Tropical Spastic / Q000821:virology*; D010523:Peripheral Nervous System Diseases / Q000821:virology*; D011533:Proviruses / Q000302:isolation & purification*; D001750:Urinary Bladder, Neurogenic / Q000821:virology; D019562:Viral Load