title: Surgical management of vascular graft infection in severely ill patients by partial resection of the infected prosthesis.
abstract: BACKGROUND
  In the presented retrospective study, we report on our results with partial resection of infected prosthetic grafts after aorto-bifemoral graft placement in eight male and three female patients.
  
  
  METHODS
  In all 11 patients clinical signs of infection were observed and bacteriological cultures were positive. Three patients underwent immediate surgery for perforation of an aneurysm at the distal anastomosis, eight patients underwent elective surgery. In all cases silver-coated Dacron prostheses were implanted. Assessment of outcome was based on survival, limb salvage, persistent or recurrent infection, and prosthetic graft patency.
  
  
  RESULTS
  In two cases, a partial wound dehiscence occurred which was treated with ambulant Vacuseal dressings for 16 and 21 days until secondary wound healing was achieved. In eight patients systemic markers of inflammation completed normalised within nine days. Follow-up CT-scans failed to demonstrate any signs of recurrent infection or peri-graft fluid collections. Patients were treated with specific antibiotic therapy for no more than three months. Post-operative bacteriological cultures were negative in all patients. The mean follow-up was 2.5+/-0.5 yrs. During follow-up, none of the patients died and there were no amputations.
  
  
  CONCLUSIONS
  Despite only partial resection of the infected prostheses, the reported surgical procedure offers good results. This approach maybe particularly suitable for the treatment of elderly patients with prosthesis infections.
authors.affiliation: Department of Cardiothoracic and Vascular Surgery, University of Goettingen, Germany. mmirzaie@web.de
authors.forename: M
authors.initials: M
authors.lastname: Mirzaie
authors.forename: J D
authors.initials: JD
authors.lastname: Schmitto
authors.forename: T
authors.initials: T
authors.lastname: Tirilomis
authors.forename: S
authors.initials: S
authors.lastname: Fatehpur
authors.forename: O J
authors.initials: OJ
authors.lastname: Liakopoulos
authors.forename: N
authors.initials: N
authors.lastname: Teucher
authors.forename: H
authors.initials: H
authors.lastname: Dörge
authors.forename: F A
authors.initials: FA
authors.lastname: Schöndube
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D017544:Aortic Aneurysm, Abdominal / Q000453:epidemiology / Q000601:surgery; D001807:Blood Vessel Prosthesis / Q000009:adverse effects*; D019917:Blood Vessel Prosthesis Implantation; D015897:Comorbidity; D003646:Debridement; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016459:Prosthesis-Related Infections / Q000453:epidemiology / Q000601:surgery*; D013529:Surgical Wound Dehiscence