title: Impact of serum C-reactive protein elevation on the left ventricular spherical change and the development of mitral regurgitation after anterior acute myocardial infarction.
abstract: OBJECTIVE
  Mitral regurgitation (MR) is frequently observed in patients with acute myocardial infarction (AMI), and is known to convey an adverse prognosis. We sought to clarify the relationship between MR and left ventricular (LV) remodeling, in association with serum C-reactive protein (CRP) elevation.
  
  
  RESULTS
  A total of 181 patients with first anterior ST-elevation AMI were examined. MR was detected in 68 patients by color Doppler echocardiography 2 weeks after AMI, and the patients with MR were associated with higher incidence of readmission for heart failure. Serum CRP was serially measured, and the peak serum CRP level was markedly increased in patients with MR compared with those without MR. Multiple logistic regression analysis showed that peak CRP tertile was an independent determinant of MR after AMI (p < 0.0001). In the substudy, the increases in LV end-diastolic volume and sphericity index were higher in patients with MR than in those without MR.
  
  
  CONCLUSIONS
  MR during the early phase of anterior AMI was associated with LV spherical change and late-phase heart failure, in association with increased serum CRP level. These findings suggest an important role of the inflammatory response in the development of ischemic MR and LV remodeling.
authors.affiliation: Division of Cardiology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Kohno
authors.forename: Toshihisa
authors.initials: T
authors.lastname: Anzai
authors.forename: Kotaro
authors.initials: K
authors.lastname: Naito
authors.forename: Yohei
authors.initials: Y
authors.lastname: Ohno
authors.forename: Hidehiro
authors.initials: H
authors.lastname: Kaneko
authors.forename: Hui-Chong
authors.initials: HC
authors.lastname: Li
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Sugano
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Maekawa
authors.forename: Shiro
authors.initials: S
authors.lastname: Iwanaga
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Asakura
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Yoshikawa
authors.forename: Satoshi
authors.initials: S
authors.lastname: Ogawa
mesh_terms: D000368:Aged; D002097:C-Reactive Protein / Q000032:analysis / Q000276:immunology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008944:Mitral Valve Insufficiency / Q000097:blood / Q000209:etiology / Q000276:immunology*; D009203:Myocardial Infarction / Q000097:blood / Q000150:complications / Q000276:immunology*; D011446:Prospective Studies; D020257:Ventricular Remodeling / Q000276:immunology*
chemical_list: D002097:C-Reactive Protein