The SAG1 Toxoplasma gondii surface protein is not required for acute ocular toxoplasmosis in mice.
The SAG1 Toxoplasma gondii surface protein stimulates acute ileitis. To determine whether SAG1 is also important in the eye, wild-type or SAG1 knockout parasites were injected intravitreally into mice. No differences in retinal damage or parasite growth were observed, indicating that unlike the case for the intestine, factors besides SAG1 are important for retinal damage.
Charles
Elizabeth
E
Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, 940 Stanton L. Young Blvd., BMSB 1034, Oklahoma City, OK 73034, USA.
Callegan
Michelle C
MC
Blader
Ira J
IJ
D000818:Animals; D000953:Antigens, Protozoan / Q000235:genetics / Q000502:physiology*; D004195:Disease Models, Animal; D005123:Eye / Q000469:parasitology; D017353:Gene Deletion; D006651:Histocytochemistry; D051379:Mice; D008810:Mice, Inbred C57BL; D008853:Microscopy; D015800:Protozoan Proteins / Q000235:genetics / Q000502:physiology*; D012160:Retina / Q000473:pathology; D014122:Toxoplasma / Q000472:pathogenicity*; D014126:Toxoplasmosis, Ocular / Q000382:microbiology*; D037521:Virulence Factors / Q000235:genetics / Q000502:physiology*
D000953:Antigens, Protozoan; D015800:Protozoan Proteins; C047168:SAG1 antigen, Toxoplasma; D037521:Virulence Factors