Beneficial effects of Foeniculum vulgare on ethanol-induced acute gastric mucosal injury in rats.
OBJECTIVE
To examine the anti-ulcerogenic and antioxidant effects of aqueous extracts of Foeniculum vulgare (FVE) on ethanol-induced gastric lesions in rats.


METHODS
FVE was administered by gavage at doses of 75, 150 and 300 mg/kg, and famotidine was used at the dose of 20 mg/kg. Following a 60 min period, all the rats were given 1 mL of ethanol (80%) by gavage. One hour after the administration of ethanol, all groups were sacrificed, and the gastric ulcer index was calculated; whole blood malondialdehyde (MDA) and reduced glutathione (GSH), serum nitrate, nitrite, ascorbic acid, retinol and beta-carotene levels were measured in all the groups.


RESULTS
It was found that pretreatment with FVE significantly reduced ethanol-induced gastric damage. This effect of FVE was highest and statistically significant in 300 mg/kg group compared with the control (4.18 +/- 2.81 vs 13.15 +/- 4.08, P < 0.001). Also, pretreatment with FVE significantly reduced the MDA levels, while significantly increased GSH, nitrite, nitrate, ascorbic acid, retinol and beta-carotene levels.


CONCLUSIONS
FVE has clearly a protective effect against ethanol-induced gastric mucosal lesion, and this effect, at least in part, depends upon the reduction in lipid peroxidation and augmentation in the antioxidant activity.
Birdane
Fatih Mehmet
FM
Department of Pharmacology, Faculty of Veterinary Medicine, Afyon Kocatepe University, Afyon, Turkey.
Cemek
Mustafa
M
Birdane
Yavuz Osman
YO
Gülçin
Ilhami
I
Büyükokuroğlu
Mehmet Emin
ME
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use; D000431:Ethanol / Q000633:toxicity*; D030001:Foeniculum; D005753:Gastric Mucosa / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D005978:Glutathione / Q000097:blood; D015227:Lipid Peroxidation; D008315:Malondialdehyde / Q000097:blood; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013276:Stomach Ulcer / Q000517:prevention & control
D000975:Antioxidants; D010936:Plant Extracts; D000431:Ethanol; D008315:Malondialdehyde; D005978:Glutathione