title: Temozolomide in the treatment of an invasive prolactinoma resistant to dopamine agonists.
abstract: Prolactinomas are common tumors of the anterior pituitary gland. While conventional therapies, including dopamine agonists, transsphenoidal surgery and radiotherapy, are usually effective in controlling tumor growth, some patients develop treatment-resistant tumors. In this report, we describe a patient with an invasive prolactinoma resistant to conventional therapy that responded to the administration of the alkylating agent, temozolomide.
authors.affiliation: Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, Tufts-New England Medical Center, Boston, MA 02111, USA.
authors.forename: Lisa M
authors.initials: LM
authors.lastname: Neff
authors.forename: Michelle
authors.initials: M
authors.lastname: Weil
authors.forename: Alan
authors.initials: A
authors.lastname: Cole
authors.forename: Thomas R
authors.initials: TR
authors.lastname: Hedges
authors.forename: William
authors.initials: W
authors.lastname: Shucart
authors.forename: Donald
authors.initials: D
authors.lastname: Lawrence
authors.forename: Jay-Jiguang
authors.initials: JJ
authors.lastname: Zhu
authors.forename: Arthur S
authors.initials: AS
authors.lastname: Tischler
authors.forename: Ronald M
authors.initials: RM
authors.lastname: Lechan
mesh_terms: D003606:Dacarbazine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D018491:Dopamine Agonists / Q000627:therapeutic use*; D019008:Drug Resistance, Neoplasm; D005260:Female; D006801:Humans; D008875:Middle Aged; D010911:Pituitary Neoplasms / Q000175:diagnosis / Q000188:drug therapy*; D011388:Prolactin / Q000097:blood; D015175:Prolactinoma / Q000175:diagnosis / Q000188:drug therapy*; D000077204:Temozolomide
chemical_list: D018491:Dopamine Agonists; D003606:Dacarbazine; D011388:Prolactin; D000077204:Temozolomide