title: [Surgical management of vertebral column metastatic disease].
abstract: The spine is the most frequent site of skeletal metastases. Among all spinal malignancies metastatic disease is most frequent and indicative of disseminating tumor disease. Depending on primary tumor entity, estimated survival time, general health status of the patient, presence of spinal instability and neurological deficits an oncological useful and patient-specific therapeutic intervention should be performed. New anterior approaches, resections and reconstruction techniques are making surgery a preferred method over radiation therapy. For differential indication of the multiple surgical treatment modalities prognostic scores are available to assist individual decision making. Indications for surgery include survival prognosis of minimum 3 months, intractable pain, progress of myelon compression and/or neurological deficits under radiochemotherapy, spinal instability and necessity for histological diagnosis. Resulting quality of life depends on efficient decompression of the spinal cord and restoration of spinal stability. To achieve these ultimate goals there are different anterior and posterior approaches, instrumentations and vertebral body replacement implants available. Preoperative embolization should be performed in hypervascular tumors, e.g., renal cell cancer. Vertebro-/Kyphoplasty as a percutaneous intervention should be considered for painful multisegmental disease and symptomatic osteolysis without epidural tumor compression to reach analgesia and stability. A multidisciplinary approach in patient selection, decision making and management is an essential precondition for complication avoidance and acceptable quality of life.
authors.affiliation: Centrum für Muskuloskeletale Chirurgie, Sektion Muskuloskeletale Tumorchirurgie, Charité-Universitätsmedizin Berlin, Klinik für Unfall- & Wiederherstellungschirurgie, Klinik für Orthopädie, 13353 Berlin. klaus-dieter.schaser@charite.de
authors.forename: K-D
authors.initials: KD
authors.lastname: Schaser
authors.forename: I
authors.initials: I
authors.lastname: Melcher
authors.forename: T
authors.initials: T
authors.lastname: Mittlmeier
authors.forename: A
authors.initials: A
authors.lastname: Schulz
authors.forename: J H
authors.initials: JH
authors.lastname: Seemann
authors.forename: N P
authors.initials: NP
authors.lastname: Haas
authors.forename: A C
authors.initials: AC
authors.lastname: Disch
mesh_terms: D000465:Algorithms; D000792:Angiography; D001843:Bone Cements / Q000627:therapeutic use; D003131:Combined Modality Therapy; D004621:Embolization, Therapeutic; D005598:Fractures, Spontaneous / Q000175:diagnosis / Q000401:mortality / Q000601:surgery; D006801:Humans; D008279:Magnetic Resonance Imaging; D019060:Minimally Invasive Surgical Procedures; D020360:Neoadjuvant Therapy; D009460:Neurologic Examination; D010348:Patient Care Team; D011128:Polyradiculopathy / Q000175:diagnosis / Q000401:mortality / Q000601:surgery; D019919:Prosthesis Implantation; D011788:Quality of Life; D013117:Spinal Cord Compression / Q000175:diagnosis / Q000401:mortality / Q000601:surgery; D016103:Spinal Fractures / Q000175:diagnosis / Q000401:mortality / Q000601:surgery; D013123:Spinal Fusion; D013125:Spinal Neoplasms / Q000175:diagnosis / Q000401:mortality / Q000556:secondary* / Q000601:surgery; D016019:Survival Analysis; D015996:Survival Rate; D014057:Tomography, X-Ray Computed
chemical_list: D001843:Bone Cements