[Application of BMP to bone repair].
Bone regeneration process involves upregulation of various bone morphogenetic proteins (BMPs) and their receptors, and several lines of evidence have demonstrated that BMP signaling plays a crucial role in bone regeneration. Recent research using conditional knockout mice of BMP-2 in limb revealed the essential role of BMP-2 during bone regeneration. Recombinant human BMPs and gene therapy of BMPs have been successfully applied to bone repair including application to dental implant.
Yamaguchi
Akira
A
Graduate School of Tokyo Medical and Dental University, Section of Oral Pathology.
D000818:Animals; D055396:Bone Morphogenetic Protein 2; D052004:Bone Morphogenetic Protein Receptors / Q000502:physiology; D019485:Bone Morphogenetic Proteins / Q000235:genetics / Q000502:physiology*; D001861:Bone Regeneration / Q000235:genetics / Q000502:physiology*; D015921:Dental Implants; D015316:Genetic Therapy; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D011994:Recombinant Proteins; D015398:Signal Transduction / Q000502:physiology; D016212:Transforming Growth Factor beta / Q000235:genetics / Q000502:physiology
C525718:BMP2 protein, human; C525719:Bmp2 protein, mouse; D055396:Bone Morphogenetic Protein 2; D019485:Bone Morphogenetic Proteins; D015921:Dental Implants; D011994:Recombinant Proteins; D016212:Transforming Growth Factor beta; D052004:Bone Morphogenetic Protein Receptors