Study of HIV Variability based on Genomic Signal Analysis of Protease and Reverse Transcriptase Genes.
The conversion of genomic sequences into digital genomic signals offers the possibility to use signal processing methods for the analysis of genomic information. The study of genomic signals reveals local and global features of chromosomes that would be difficult to identify by using only the symbolic representation used in genomic data bases. The paper presents a study of the HIV Protease (PR) and Reverse Transcriptase (RT) genes by combining standard nucleotide sequence analysis with IT techniques based on the genomic signal approach. Cumulated and unwrapped phases of genomic signals are analyzed to characterize the variability of clade F HIV-1 strains isolated in Romania.
Dan Cristea
Paul
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Senior Member, IEEE, Biomedical Engineering Center (BMEC) of the University "Politehnica" of Bucharest (UPB), Spl. Independentei 313, 060042 Bucharest, Romania phone: +40-21-4114437; fax: +40-21-4104414; e-mail: pcristea@dsp.pub.ro.
Aurora Tuduce
Rodica
R
Otelea
Dan
D