Early pharmacological treatment of autism: a rationale for developmental treatment.
Autism is a dynamic neurodevelopmental syndrome in which disabilities emerge during the first three postnatal years and continue to evolve with ongoing development. We briefly review research in autism describing subtle changes in molecules important in brain development and neurotransmission, in morphology of specific neurons, brain connections, and in brain size. We then provide a general schema of how these processes may interact with particular emphasis on neurotransmission. In this context, we present a rationale for utilizing pharmacologic treatments aimed at modifying key neurodevelopmental processes in young children with autism. Early treatment with selective serotonin reuptake inhibitors (SSRIs) is presented as a model for pharmacologic interventions because there is evidence in autistic children for reduced brain serotonin synthesis during periods of peak synaptogenesis; serotonin is known to enhance synapse refinement; and exploratory studies with these agents in autistic children exist. Additional hypothetical developmental interventions and relevant published clinical data are described. Finally, we discuss the importance of exploring early pharmacologic interventions within multiple experimental settings in order to develop effective treatments as quickly as possible while minimizing risks.
Bethea
Terrence C
TC
Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Sikich
Linmarie
L
D000818:Animals; D001321:Autistic Disorder / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D001921:Brain / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism / Q000473:pathology; D018479:Early Intervention, Educational; D006801:Humans; D018377:Neurotransmitter Agents / Q000378:metabolism; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use*
D018377:Neurotransmitter Agents; D017367:Selective Serotonin Reuptake Inhibitors