title: A search for a mutation of the Aiolos phosphorylation domain in lymphocytes from patients with leukemia.
abstract: We examined whether phosphorylation of Aiolos in primary human lymphocytes is part of the malignant transformation in leukemia. By analyzing mutations at a restriction site we show here that impairment of Aiolos activity in human leukemia is not based on deficient phosphorylation as had been demonstrated in experiments in vitro.
authors.forename: Mariastefania
authors.initials: M
authors.lastname: Antica
authors.forename: Klara
authors.initials: K
authors.lastname: Dubravcic
authors.forename: I
authors.initials: I
authors.lastname: Weber
authors.forename: Ljubica
authors.initials: L
authors.lastname: Raic
authors.forename: Boris
authors.initials: B
authors.lastname: Labar
authors.forename: Drago
authors.initials: D
authors.lastname: Batinic
mesh_terms: D004252:DNA Mutational Analysis; D006801:Humans; D051740:Ikaros Transcription Factor; D007938:Leukemia / Q000097:blood* / Q000235:genetics*; D008214:Lymphocytes / Q000166:cytology*; D009154:Mutation; D010766:Phosphorylation; D017434:Protein Structure, Tertiary; D015534:Trans-Activators / Q000097:blood* / Q000737:chemistry / Q000235:genetics*; D014157:Transcription Factors; D016335:Zinc Fingers
chemical_list: C106285:IKZF3 protein, human; D015534:Trans-Activators; D014157:Transcription Factors; D051740:Ikaros Transcription Factor