Microencapsulation of insulin into biodegradable microcapsules by the high voltage field method.
To produce and evaluate sustained microcapsules of insulin made by a novel encapsulation process. The insulin was encapsulated into microcapsules of poly(D, L-lactide co-glycolide) (PLGA) by the high voltage field method. The preparation process was cryogenic, non-aqueous, and did not utilize emulsification. When the ratio of insulin/PLGA was 1:9, the median particle size of insulin microcapsules was less than 200&#956;m, the drug loaded was 8.82%, and the efficiency of encapsulation was 83.2%. Drug release continued over 300h. In conclusion, the process was a novel way to produce insulin microcapsules, and the basic characteristics were satisfactory.
Zhou
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Institute of Cryomedicine Biology and Food Science, University of Shanghai for science and technology, shanghai, CHINA(phone:021-65683401, e-mail: nekons@163.com).
Li
Baoguo
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Du
Wei
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