title: The Fc gammaRIIa polymorphism in Turkish children with asthma bronchial and allergic rhinitis.
abstract: OBJECTIVE
  The aim of the present study was to evaluate the Fc gammaRIIa polymorphism in Turkish children with atopic asthma and allergic rhinitis.
  
  
  METHODS
  In this study, 372 atopic children (192 asthma bronchial, 180 allergic rhinitis) between ages of 5 and 16 years old (11.3+/-2.9) who were followed at Aegean University Paediatric Allergy and Pulmonology Outpatient Clinics and 234 healthy subjects as the control group were included. The evaluation of subjects included routine biochemical blood analysis and allergic workup based on the following laboratory determinants. The Fc gammaRIIa polymorphism was determined using the polymerase chain reaction method.
  
  
  RESULTS
  Distribution of R131R genotype was significantly different among patient groups compared to controls (for asthmatic children OR: 2.64 95%CI: 1.22-5.79, p=0.006; for allergic rhinitis OR: 2.58 95%CI: 1.18-5.71, p=0.009). Frequency of 131R allele was significantly different among patient groups compared to controls (for asthmatic children OR: 1.66 95%CI: 1.22-2.26, p=0.0007; for allergic rhinitis OR: 1.93 95%CI: 1.42-2.63, p=0.00001).
  
  
  CONCLUSIONS
  This study shows that Fc gammaRIIa gene 131R allele represents an important genetic risk factor for bronchial asthma and allergic rhinitis susceptibility.
authors.affiliation: Aegean University School of Medicine, Department of Paediatrics, Division of Allergy and Pulmonology, TR-35100, Bornova/Izmir, Turkey. figen.gulen@ege.edu.tr
authors.forename: Figen
authors.initials: F
authors.lastname: Gulen
authors.forename: Remziye
authors.initials: R
authors.lastname: Tanac
authors.forename: Serdar
authors.initials: S
authors.lastname: Altinoz
authors.forename: Afig
authors.initials: A
authors.lastname: Berdeli
authors.forename: Dost
authors.initials: D
authors.lastname: Zeyrek
authors.forename: Huseyin
authors.initials: H
authors.lastname: Koksoy
authors.forename: Esen
authors.initials: E
authors.lastname: Demir
mesh_terms: D000293:Adolescent; D015703:Antigens, CD / Q000235:genetics*; D001249:Asthma / Q000235:genetics / Q000473:pathology*; D016022:Case-Control Studies; D002648:Child; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D017452:Receptors, IgG / Q000235:genetics*; D012221:Rhinitis, Allergic, Perennial / Q000235:genetics / Q000473:pathology*; D014421:Turkey
chemical_list: D015703:Antigens, CD; C080568:Fc gamma receptor IIA; D017452:Receptors, IgG