Recent progress in the field of glycopeptide synthesis.
Glycosylation is a common post-translational modification of proteins. Although its significance in biological system is well recognized, approaches to analyze carbohydrate function are limited. This is because of difficulty in obtaining homogeneous glycoproteins from natural sources. Due to the progress of the carbohydrate and peptide chemistry, syntheses of various homogeneous glycopeptides and glycoproteins, which are suitable for biological studies, have been achieved by chemical means. In this review, we briefly summarize recent advances in the field of glycopeptide synthesis after 1999.
Hojo
Hironobu
H
Department of Applied Biochemistry, Institute of Glycotechnology, Tokai University, Kitakaname 1117, Hiratsuka, Kanagawa, Japan. hojo@keyaki.cc.u-tokai.ac.jp
Nakahara
Yoshiaki
Y
D000595:Amino Acid Sequence; D002240:Carbohydrate Sequence; D006020:Glycopeptides / Q000138:chemical synthesis* / Q000737:chemistry; D006031:Glycosylation; D017261:Glycosylphosphatidylinositols / Q000138:chemical synthesis / Q000737:chemistry; D008722:Methods; D008969:Molecular Sequence Data; D015394:Molecular Structure; D019151:Peptide Library
D006020:Glycopeptides; D017261:Glycosylphosphatidylinositols; D019151:Peptide Library