Design of original bioactive formulations based on sugar-surfactant/non-steroidal anti-inflammatory catanionic self-assemblies: a new way of dermal drug delivery.
A new kind of catanionic assembly was developed that associates a sugar-based surfactant with a non-steroidal anti-inflammatory drug (NSAID). Three different assemblies using indomethacin, ibuprofen and ketoprofen as NSAIDs were easily obtained in water by an acid-base reaction. These assemblies formed new amphiphilic entities because of electrostatic and hydrophobic effects in water and led to the spontaneous formation of vesicles. These catanionic vesicles were then tested as potential NSAID delivery systems for dermatological application. The anti-inflammatory activity was evaluated in vivo, and this study clearly showed an improved therapeutic effect for NSAIDs that were formulated as catanionic vesicles. These vesicles ensured a slower diffusion of the NSAID through the skin. This release probably increased the time of retention of the NSAID in the targeted strata of the skin. Thus, the present study suggests that this catanionic bioactive formulation could be a promising dermal delivery system for NSAIDs in the course of skin inflammation treatment.
Consola
Sabrina
S
Laboratoire des Interactions Moléculaires et Réactivité Chimique et Photochimique, UMR 5623, 31062 Toulouse cedex 4, France.
Blanzat
Muriel
M
Perez
Emile
E
Garrigues
Jean-Christophe
JC
Bordat
Pascal
P
Rico-Lattes
Isabelle
I
D000287:Administration, Topical; D000818:Animals; D000838:Anions; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D016718:Arachidonic Acid / Q000633:toxicity; D002412:Cations / Q000737:chemistry*; D004337:Drug Carriers; D016503:Drug Delivery Systems; D015195:Drug Design; D004423:Ear; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D007052:Ibuprofen / Q000008:administration & dosage; D007213:Indomethacin / Q000008:administration & dosage; D007660:Ketoprofen / Q000008:administration & dosage; D008297:Male; D051379:Mice; D010539:Permeability; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D012869:Skin Absorption / Q000187:drug effects / Q000502:physiology*; D013501:Surface-Active Agents / Q000737:chemistry*; D013552:Swine
D000838:Anions; D000894:Anti-Inflammatory Agents, Non-Steroidal; D002412:Cations; D004337:Drug Carriers; D004364:Pharmaceutical Preparations; D013501:Surface-Active Agents; D016718:Arachidonic Acid; D007660:Ketoprofen; D007052:Ibuprofen; D007213:Indomethacin