Good players left on the sidelines: why some synaptic vesicles don't get in the game.
A key question in synaptic physiology is what determines the release probability of a synaptic vesicle. In this issue of Neuron, Wadel et al. shed UV light on this problem, finding that hard-to-release vesicles are too far from Ca2+ channels.
Price
Gareth D
GD
Oregon Hearing Research Center / Vollum Institute, Oregon Health and Science University, Portland, OR 97239, USA.
Trussell
Laurence O
LO
D000818:Animals; D017729:Presynaptic Terminals; D013569:Synapses / Q000502:physiology*; D009435:Synaptic Transmission / Q000502:physiology*; D013572:Synaptic Vesicles / Q000502:physiology*