The metabolic sensor GCN2 branches out.
GCN2 is a sensor of amino acid deprivation that triggers a repression of global protein synthesis while simultaneously inducing translation of specific proteins. In this issue of Cell Metabolism, Guo and Cavener (2007) present a much broader role for GCN2 in controlling lipid homeostasis in response to amino acid deprivation.
Towle
Howard C
HC
Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA. towle@mail.ahc.umn.edu
D000818:Animals; D006801:Humans; D007930:Leucine / Q000172:deficiency; D050356:Lipid Metabolism; D008099:Liver / Q000201:enzymology / Q000378:metabolism; D051379:Mice; D017346:Protein Serine-Threonine Kinases / Q000172:deficiency / Q000378:metabolism*
C070634:Eif2ak4 protein, mouse; D017346:Protein Serine-Threonine Kinases; D007930:Leucine