title: The influence of electromagnetic field irradiated by high-voltage transmission lines on properties of cells.
abstract: The influence of low-frequency electromagnetic field irradiating by high-voltage transmission lines on signal transduction of cell in spleen cells of the rates have been studied by molecular-biology techniques. The spleen cells are extracted from skilled rates, which are exposed in the electromagnetic field of high-voltage transmission lines with 4000 V/m and 0.09-0.1 G about 400 days. The quantity or level of phosphorylation of signal transducer and activator of transcription (STAT3) in JAK-STAT signal transduction pathway of spleen cells, which are stimulated and unstimulated by IL-2, respectively, are detected by the immunoblotting and immunobiochemistry. The results show that the expression of phospho-STAT3 in spleen cell stimulated by IL-2 differ not from that in the unstimulated cell. The former is significantly large than the latter. This shows that signal transduction of cell is affected by this electromagnetic field. The spectra of infrared absorption for the general G-proteins participating this signal transduction of cell for the controlled and exposed groups, which are measured by Nicoletic FT-IR 670 spectrometer, are obviously different both the intensity and frequency of these peaks. This shows that molecular structure or conformation of the proteins changes under influence of the electromagnetic field of high-voltage transmission lines, which results just to above changes of the JAK-STAT signal transduction of cell.
authors.affiliation: Inst. of Life Sci. & Technol., Univ. of Electron. Sci. & Technol., Chengdu.
authors.forename: Pang
authors.initials: P
authors.lastname: Xiao-Feng
authors.forename: Yuan
authors.initials: Y
authors.lastname: Ping