Estimation of influence of gastric emptying on shape of glucose concentration-time profile measured in oral glucose tolerance test.
OBJECTIVE
To develop a model for simulations of processes in the oral glucose tolerance test (OGTT), using tools of the theory of dynamic systems.


METHODS
Frequent sampling OGTT was performed in 13 healthy subjects (6 males and 7 females). Subsequently, employing glucose and insulin concentration-time profiles of the subjects, the model was developed.


RESULTS
In all subjects the model was able to simulate influences of the insulin plasma concentration and gastric emptying rate on glucose concentration and to determine time profiles of glucose fractions retained in stomach.


CONCLUSIONS
The approach presented represents an opportunity for building models for data analyses in OGTT.
Dedík
Ladislav
L
Faculty of Mechanical Engineering, Slovak University of Technology, Slobody 17, 812 31 Bratislava, Slovak Republic. ladislav.dedik@stuba.sk
Durisová
Mária
M
Penesová
Adela
A
Miklovicová
Daniela
D
Tvrdonová
Martina
M
D000328:Adult; D001786:Blood Glucose / Q000032:analysis*; D005260:Female; D005746:Gastric Emptying; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood; D007700:Kinetics; D008297:Male; D008954:Models, Biological; D008962:Models, Theoretical
D001786:Blood Glucose; D007328:Insulin