title: Cinnamacrins A-C, cinnafragrin D, and cytostatic metabolites with alpha-glucosidase inhibitory activity from Cinnamosma macrocarpa.
abstract: Two new monomeric and two new dimeric drimane sesquiterpenes, cinnamacrins A-C (1-3) and cinnafragrin D (4), along with bemadienolide (5), capsicodendrin (6), cinnamodial (7), cinnamolide (8), isopolygodial (9), and delta-tocotrienol (10), were isolated from Cinnamosma macrocarpa. The structures of the new compounds were determined by physical, chemical, and spectroscopic evidence. Capsicodendrin (6) and/or cinnamodial (7) are the major compounds in C. fragrans and C. macrocarpa, which are both widely used in Malagasy traditional medicine. The cytostatic activity as well as alpha-glucosidase inhibition and antiviral activities of the major constituents 6 and 7 and the compounds previously isolated from C. fragrans were evaluated.
authors.affiliation: Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima 770-8514, Japan.
authors.forename: Liva
authors.initials: L
authors.lastname: Harinantenaina
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Asakawa
authors.forename: Erik
authors.initials: E
authors.lastname: De Clercq
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D004770:Enterovirus / Q000187:drug effects; D065089:Glycoside Hydrolase Inhibitors; D006801:Humans; D008270:Madagascar; D019684:Magnoliopsida / Q000737:chemistry*; D008519:Medicine, Traditional; D051379:Mice; D008968:Molecular Conformation; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*; D012136:Respiratory Syncytial Viruses / Q000187:drug effects; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018139:Simplexvirus / Q000187:drug effects; D013601:T-Lymphocytes / Q000187:drug effects; D014616:Vaccinia virus / Q000187:drug effects
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D065089:Glycoside Hydrolase Inhibitors; D012717:Sesquiterpenes