Interaction between C-reactive protein and endothelin-1 in coronary artery disease.
BACKGROUND
Increased concentrations of serum C-reactive protein (CRP) have been reported to predict major cardiovascular events in patients with coronary artery disease (CAD). Increased concentrations of endothelin-1 (ET-1) are also associated with poor prognosis after myocardial infarction.


OBJECTIVE
We tested the hypothesis that ET-1 might contribute to CRP in prediction of adverse outcome in CAD.


METHODS
Serum high sensitive CRP and plasma ET-1 levels of 40 patients who have stable CAD and 25 control subjects were measured, and correlation analysis between these molecules was performed.


RESULTS
Mean high sensitive CRP was 8.64 +/- 12.73 mg/l, and mean ET-1 was 8.24 +/- 7.06 pg/ml in the CAD group. We found that there was no statistically significant correlation between high sensitive CRP and ET-1 in either CAD group (p = 0.82), or the control group (p = 0.85). In a subgroup of 13 patients who were not under statin treatment, we found a strong correlation between the levels of these molecules (p = 0.01).


CONCLUSIONS
Our study does not clearly support or exclude a link between CRP and ET-1 in patients who have stable CAD.
Gemici
Gökmen
G
Marmara University School of Medicine, Istanbul, Turkey. kardiyolog@ttnet.net.tr
Erdim
Refik
R
Tokay
Sena
S
Tezcan
Hakan
H
Fak
A Serdar
AS
Oktay
Ahmet
A
D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis*; D003324:Coronary Artery Disease / Q000097:blood*; D003430:Cross-Sectional Studies; D019332:Endothelin-1 / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D011237:Predictive Value of Tests; D011446:Prospective Studies
D015415:Biomarkers; D019332:Endothelin-1; D002097:C-Reactive Protein