title: Discovery of tertiary aminoacids as dual PPARalpha/gamma agonists-I.
abstract: A novel series of potent dual agonists of PPARalpha and PPARgamma, the alkoxybenzylglycines, was identified and explored using a solution-phase library approach. The synthesis and structure-activity relationships of this series of dual PPARalpha/gamma agonists are described.
authors.affiliation: Discovery Chemistry, Bristol-Myers Squibb Pharmaceutical Research Institute, PO Box 5400, Princeton, NJ 08543-5400, USA. pratik.devasthale@bms.com
authors.forename: Pratik V
authors.initials: PV
authors.lastname: Devasthale
authors.forename: Sean
authors.initials: S
authors.lastname: Chen
authors.forename: Yoon
authors.initials: Y
authors.lastname: Jeon
authors.forename: Fucheng
authors.initials: F
authors.lastname: Qu
authors.forename: Denis E
authors.initials: DE
authors.lastname: Ryono
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.forename: Hao
authors.initials: H
authors.lastname: Zhang
authors.forename: Lin
authors.initials: L
authors.lastname: Cheng
authors.forename: Dennis
authors.initials: D
authors.lastname: Farrelly
authors.forename: Rajasree
authors.initials: R
authors.lastname: Golla
authors.forename: Gary
authors.initials: G
authors.lastname: Grover
authors.forename: Zhengping
authors.initials: Z
authors.lastname: Ma
authors.forename: Lisa
authors.initials: L
authors.lastname: Moore
authors.forename: Ramakrishna
authors.initials: R
authors.lastname: Seethala
authors.forename: Wei
authors.initials: W
authors.lastname: Sun
authors.forename: Arthur M
authors.initials: AM
authors.lastname: Doweyko
authors.forename: Gamini
authors.initials: G
authors.lastname: Chandrasena
authors.forename: Paul
authors.initials: P
authors.lastname: Sleph
authors.forename: Narayanan
authors.initials: N
authors.lastname: Hariharan
authors.forename: Peter T W
authors.initials: PT
authors.lastname: Cheng
mesh_terms: D000596:Amino Acids / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D001786:Blood Glucose / Q000187:drug effects; D005998:Glycine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000494:pharmacology; D000960:Hypolipidemic Agents / Q000737:chemistry / Q000494:pharmacology; D051379:Mice; D008815:Mice, Inbred Strains; D047493:PPAR alpha / Q000819:agonists*; D047495:PPAR gamma / Q000819:agonists*; D013329:Structure-Activity Relationship
chemical_list: D000596:Amino Acids; D001786:Blood Glucose; D007004:Hypoglycemic Agents; D000960:Hypolipidemic Agents; D047493:PPAR alpha; D047495:PPAR gamma; D005998:Glycine