Synthesis of peptide-based polymers by microwave-assisted cycloaddition backbone polymerization.
The optimized reaction conditions for the Cu(I)-catalyzed N-->C polymerization of azido-phenylalanyl-alanyl-propargyl amide to yield either high molecular weight linear polymers or medium-sized cyclic polymers is described. These reaction conditions will be applied to tailor the synthesis, properties, and structure of biologically relevant peptide-based biopolymers.
Dijk
Maarten van
Mv
Department of Medicinal Chemistry and Chemical Biology, and Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, P.O. Box 80082, 3508 TB Utrecht, The Netherlands.
Mustafa
Khalid
K
Dechesne
Annemarie C
AC
Nostrum
Cornelus F van
CF
Hennink
Wim E
WE
Rijkers
Dirk T S
DT
Liskamp
Rob M J
RM
D000577:Amides / Q000737:chemistry; D001704:Biopolymers; D002384:Catalysis; D003300:Copper; D008872:Microwaves; D010455:Peptides / Q000138:chemical synthesis*; D011108:Polymers / Q000138:chemical synthesis*
D000577:Amides; D001704:Biopolymers; D010455:Peptides; D011108:Polymers; D003300:Copper