title: Drosophila Anaplastic Lymphoma Kinase regulates Dpp signalling in the developing embryonic gut.
abstract: The Drosophila melanogaster gene Anaplastic Lymphoma Kinase (Alk) regulates a signal transduction pathway required for founder cell specification within the visceral muscle of the developing embryonic midgut. During embryonic development, the midgut visceral muscle is lined by the endodermal cell layer. In this paper, we have investigated signalling between these two tissues. Here, we show that Alk function is required for decapentaplegic (Dpp) expression and subsequent signalling via the Mad pathway in the developing gut. We propose that not only does Alk signalling regulate founder cell specification and thus fusion in the developing visceral muscle, but that Alk also regulates Dpp signalling between the visceral muscle and the endoderm. This provides an elegant mechanism with which to temporally coordinate visceral muscle fusion and later events in midgut development.
authors.affiliation: Umeå Center for Molecular Pathogenesis Umeå University Building 6L, Umeå S-901 87 Sweden.
authors.forename: Margret
authors.initials: M
authors.lastname: Shirinian
authors.forename: Gaurav
authors.initials: G
authors.lastname: Varshney
authors.forename: Christina E
authors.initials: CE
authors.lastname: Lorén
authors.forename: Caroline
authors.initials: C
authors.lastname: Grabbe
authors.forename: Ruth H
authors.initials: RH
authors.lastname: Palmer
mesh_terms: D000077548:Anaplastic Lymphoma Kinase; D000818:Animals; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism*; D004331:Drosophila melanogaster / Q000033:anatomy & histology / Q000196:embryology* / Q000201:enzymology; D004625:Embryo, Nonmammalian / Q000378:metabolism*; D004707:Endoderm / Q000166:cytology / Q000378:metabolism; D005260:Female; D018507:Gene Expression Regulation, Developmental; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000196:embryology*; D008648:Mesoderm / Q000166:cytology / Q000378:metabolism; D011505:Protein-Tyrosine Kinases / Q000235:genetics / Q000378:metabolism*; D020794:Receptor Protein-Tyrosine Kinases; D015398:Signal Transduction
chemical_list: D029721:Drosophila Proteins; C064196:dpp protein, Drosophila; D000077548:Anaplastic Lymphoma Kinase; D011505:Protein-Tyrosine Kinases; D020794:Receptor Protein-Tyrosine Kinases