[Renal tubular epithelocytic changes in hypercysteinemia and experimental chronic renal failure].
One group of adult male Wistar rats received DL-homocysteine, 13.4 mg/kg body weight every day (an HC-group) while the rats underwent subtotal nephrectomy (a SN-group) and were killed 3 weeks later. Both light and electron microscopies were used to analyze obtained renal specimens. A total loss of the brush border in some proximal tubular (PT) cells and an increase of autophagosomes and emergence of the loci of disorganized cytoplasm were observed in the HC-group, while in the SN-group there was a significant increase in the number and size of secondary lysosomes and of foci of the cytoplasmic disorganization.
Sipovskiĭ
V G
VG
Nepovorotin
A I
AI
Smirtnov
A V
AV
Dobronravov
V A
VA
Khokhlov
S E
SE
Petrishchev
N N
NN
Barabanova
V V
VV
Chefu
S G
SG
Borisova
E A
EA
D000818:Animals; D001343:Autophagy; D003593:Cytoplasm / Q000648:ultrastructure*; D006710:Homocysteine / Q000633:toxicity; D007668:Kidney / Q000648:ultrastructure*; D007676:Kidney Failure, Chronic / Q000139:chemically induced / Q000473:pathology*; D008247:Lysosomes / Q000648:ultrastructure*; D008297:Male; D009392:Nephrectomy; D051381:Rats; D017208:Rats, Wistar
D006710:Homocysteine