Skin gammadelta T-cell functions in homeostasis and wound healing.
There is a resident population of T cells found in murine skin that expresses an invariant Vgamma3Vdelta1 T-cell receptor (TCR), and these cells are significantly different from lymphoid gammadelta T cells and alphabeta T cells in terms of ontogeny, tissue tropism, and antigen receptor diversity. These dendritic epidermal T cells are derived from fetal thymic precursor cells, are in constant contact with neighboring epidermal cells, and express a monoclonal gammadeltaTCR only found in the skin. Skin gammadelta T cells have been shown to play unique roles in tissue homeostasis and during tissue repair through local secretion of distinct growth factors including keratinocyte growth factors and insulin-like growth factor-1. In this review, we discuss evidence supporting a role for cross talk between skin gammadelta T cells and keratinocytes that contributes to the maintenance of normal skin and wound healing.
Jameson
Julie
J
Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Havran
Wendy L
WL
D000818:Animals; D003713:Dendritic Cells / Q000166:cytology / Q000276:immunology; D006706:Homeostasis / Q000276:immunology*; D006801:Humans; D015603:Keratinocytes / Q000166:cytology / Q000276:immunology; D051379:Mice; D020239:Receptor Cross-Talk / Q000276:immunology; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000276:immunology*; D012867:Skin / Q000166:cytology* / Q000276:immunology*; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D014945:Wound Healing / Q000276:immunology*
D016692:Receptors, Antigen, T-Cell, gamma-delta