Fly foie gras: modeling fatty liver in Drosophila.
Lipids provide an essential source of metabolites and energy in normal development as well as during periods of food deprivation. A recent study in Drosophila (Gutierrez et al., 2007) reveals a novel role in regulating lipid metabolism for specialized cells called oenocytes that present striking functional similarities to mammalian hepatocytes.
Arquier
Nathalie
N
University of Nice/CNRS UMR6543, Institute for Signaling, Developmental Biology and Cancer, Parc Valrose, 06108 Nice Cedex 2, France.
Léopold
Pierre
P
D000818:Animals; D004195:Disease Models, Animal; D004331:Drosophila melanogaster / Q000378:metabolism*; D005216:Fat Body / Q000378:metabolism; D005234:Fatty Liver / Q000378:metabolism* / Q000473:pathology; D022781:Hepatocytes / Q000378:metabolism; D050356:Lipid Metabolism