title: 4-Methyl-1,2,3-selenadiazole-5-carboxylic acid amides: antitumor action and cytotoxic effect correlation.
abstract: Synthesis and cytotoxic activity of a series of 4-methyl-1,2,3-selenadiazole-5-carboxylic acid amides on human fibrosarcoma HT-1080, mouse hepatoma MG-22A, and mouse fibroblasts 3T3 cell lines are described. The correlation between compound LD(50) and 3T3 fibroblast cell line morphology was shown. In vivo evaluation of amides on mouse sarcoma S-180 confirms high antitumor activity (58-85%).
authors.affiliation: Department of Medicinal Chemistry, Latvian Institute of Organic Synthesis, Aizkraukles 21, Riga, Latvia. pavel.arsenyan@lycos.com
authors.forename: Pavel
authors.initials: P
authors.lastname: Arsenyan
authors.forename: Kira
authors.initials: K
authors.lastname: Rubina
authors.forename: Irina
authors.initials: I
authors.lastname: Shestakova
authors.forename: Ilona
authors.initials: I
authors.lastname: Domracheva
mesh_terms: D016475:3T3 Cells; D000577:Amides / Q000494:pharmacology*; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002264:Carboxylic Acids / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007928:Lethal Dose 50; D051379:Mice
chemical_list: D000577:Amides; D000970:Antineoplastic Agents; D002264:Carboxylic Acids