title: Detection of microembolic signals with transcranial Doppler ultrasound.
abstract: Detection of microembolic signals (MES) with transcranial Doppler was introduced in the late 1980s; several animal and in vitro models reported a high sensitivity and specificity with this technique. Monitoring for MES in various patient groups has provided valuable insights on stroke pathophysiology, although its clinical value remains a matter of debate. Diagnosis of imminent occlusion of the internal carotid artery following carotid endarterectomy, selection of high-risk patients with asymptomatic carotid disease, and evaluation of drug efficacy constitute potential applications of this technique.
authors.affiliation: Department of Neurology, University of Zürich, Zürich, Switzerland; Department of Neurology, University of Düsseldorf, Düsseldorf, Germany.
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Georgiadis
authors.forename: Mario
authors.initials: M
authors.lastname: Siebler
mesh_terms: D006348:Cardiac Surgical Procedures / Q000009:adverse effects; D002341:Carotid Artery Thrombosis / Q000000981:diagnostic imaging* / Q000503:physiopathology / Q000517:prevention & control; D002536:Cerebral Arteries / Q000000981:diagnostic imaging* / Q000473:pathology / Q000503:physiopathology; D016894:Endarterectomy, Carotid / Q000009:adverse effects; D006801:Humans; D002542:Intracranial Embolism and Thrombosis / Q000000981:diagnostic imaging* / Q000503:physiopathology / Q000517:prevention & control; D008833:Microcirculation / Q000000981:diagnostic imaging* / Q000473:pathology / Q000503:physiopathology; D008991:Monitoring, Physiologic / Q000295:instrumentation / Q000379:methods / Q000639:trends; D011183:Postoperative Complications / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000517:prevention & control; D017585:Ultrasonography, Doppler, Transcranial / Q000379:methods* / Q000592:standards / Q000639:trends