Functional results after radiochemotherapy and total mesorectal excision for rectal cancer.
OBJECTIVE
The aim of this study was to prospectively define and measure evacuation and continence disorders after preoperative radiochemotherapy and total mesorectal excision (TME) for rectal cancer 1 year after surgery.


METHODS
We submitted 100 patients, who underwent neoadjuvant treatment and anterior resection with TME from 1996 to 2003, to a questionnaire on postoperative continence and evacuation. Anal sphincter function was further assessed by the Memorial Sloan-Kettering score. Factors influencing anorectal function were examined in univariate and multivariate analysis.


RESULTS
Median evacuation score was 16.12 +/- 5.12 (range 0-28). Sensation of incomplete evacuation was reported in 58% of cases, necessity to return to the bathroom <15 min in 37% and inability to evacuate completely <15 min in 35%. Median continence score was 13.7 +/- 4.79 (range 0-20). Incontinence to flatus was reported in 46% of cases. Colonic J-pouch allows better evacuation and continence. Continence was also better in absence of postoperative complications. Sphincter function resulted excellent or good in 75% of patients according to the Memorial Sloan-Kettering score.


CONCLUSIONS
The most frequent symptoms in our series are the sensation of incomplete evacuation, the incontinence to flatus, and the necessity to return to the bathroom <15 min. Colonic J-pouch warrants a better function. Postoperative complications compromise good functional results.
Coco
C
C
Department of Surgery, Università Cattolica del Sacro Cuore, Rome, Italy.
Valentini
V
V
Manno
A
A
Rizzo
G
G
Gambacorta
M A
MA
Mattana
C
C
Verbo
A
A
Picciocchi
A
A
D000368:Aged; D001003:Anal Canal / Q000503:physiopathology*; D000714:Anastomosis, Surgical / Q000009:adverse effects; D017024:Chemotherapy, Adjuvant; D039021:Colonic Pouches / Q000009:adverse effects*; D003672:Defecation; D013505:Digestive System Surgical Procedures / Q000009:adverse effects*; D005242:Fecal Incontinence / Q000209:etiology* / Q000503:physiopathology; D005414:Flatulence / Q000209:etiology* / Q000503:physiopathology; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D020360:Neoadjuvant Therapy / Q000009:adverse effects; D017060:Patient Satisfaction; D011446:Prospective Studies; D018714:Radiotherapy, Adjuvant / Q000009:adverse effects; D020127:Recovery of Function; D012004:Rectal Neoplasms / Q000188:drug therapy / Q000503:physiopathology / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D011795:Surveys and Questionnaires; D013997:Time Factors; D016896:Treatment Outcome