Practical aspects of intensive insulinization in the intensive care unit.
OBJECTIVE
Strategies used for intensive insulin therapy of critically ill patients and differences of approach according to medical condition are reviewed.


RESULTS
Acceptance of proposed glycemic targets for critically ill patients has been tempered by uncertainties about benefit of strict glycemic control for specific target subpopulations, differences between treatment centers, optimal timing and duration of intervention, and safety. Present-day intravenous insulin infusion protocols may perform well only for restricted populations. Assessment of protocol performance requires knowledge of algorithm behavior on or near the narrow target range and, using the patient as unit of observation, examination of glycemic variability. Systems of the future will permit adjustment of algorithm parameters to meet individual- or population-specific targets and match carbohydrate exposure.


CONCLUSIONS
Attainment and preservation of glycemic control among critically ill patients are best attempted with intravenous insulin infusion. Advances in the design of decision support and insulin delivery systems, and progress in the technology of continuous blood glucose monitoring, are likely to reduce the risk of hypoglycemia, without compromise of target range control, such that the patient outcomes enjoyed by experienced centers in the future will prove generalizable to others through the extension of new technologies.
Boulkina
Lioubov S
LS
University of North Carolina, Chapel Hill, NC 27713, USA.
Braithwaite
Susan S
SS
D001786:Blood Glucose / Q000032:analysis / Q000378:metabolism*; D003422:Critical Care / Q000379:methods / Q000592:standards; D016638:Critical Illness / Q000628:therapy*; D006801:Humans; D006943:Hyperglycemia / Q000517:prevention & control*; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D007262:Infusions, Intravenous; D007328:Insulin / Q000627:therapeutic use*; D007362:Intensive Care Units; D019095:Point-of-Care Systems
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin