title: Mechanical characterization of pharmaceutical solids: a comparison between rheological tests performed under static and dynamic porosity conditions.
abstract: The aim of this work was to verify how and to what extent rheological tests, carried out under dynamic (Heckel) and static (creep, stress/strain) porosity conditions, may serve as a valuable complement to the classic Heckel tests in the characterization of viscoelastic and densification properties of solid materials for pharmaceutical use. Six different modified (pregelatinized) starches were compressed in a rotary tablet machine equipped to measure force and punch displacement. Tablets were obtained using flat-faced 6mm diameter punches at different compression pressures. Compression cycles performed at the maximal pressure of 200MPa were used to build the Heckel plots. Ejected tablets at the 10%, 20%, 30%, and 40% porosity levels were used for the stress/strain and creep tests. Parameters obtained with both types of tests were consistent with each other. In particular, among the six starches, lower viscosity values corresponded to lower P(Y) values, and lower elastic modulus values corresponded to lower elastic recovery of the tablet. Mechanical properties of materials can be better characterized if viscoelastic tests performed under dynamic porosity conditions (Heckel analysis) are supported by classical viscoelastic tests carried out under conditions of static porosity.
authors.affiliation: Department of Chemical Sciences, University of Camerino, Camerino (MC), Italy.
authors.forename: Giulia
authors.initials: G
authors.lastname: Bonacucina
authors.forename: Marco
authors.initials: M
authors.lastname: Cespi
authors.forename: Monica
authors.initials: M
authors.lastname: Misici-Falzi
authors.forename: Giovanni F
authors.initials: GF
authors.lastname: Palmieri
mesh_terms: D000465:Algorithms; D004339:Drug Compounding; D004548:Elasticity; D005079:Excipients; D006813:Humidity; D016062:Porosity; D011312:Pressure; D012212:Rheology / Q000379:methods*; D013213:Starch; D013314:Stress, Mechanical; D013607:Tablets; D014783:Viscosity
chemical_list: D005079:Excipients; D013607:Tablets; D013213:Starch