title: Preventing bovine mastitis by a postmilking teat disinfectant containing acidified sodium chlorite.
abstract: A split-herd study was performed to determine if an acidified, sodium chlorite teat disinfectant, UDDERgold Platinum Germicidal Barrier Teat Dip (UG Pt, Ecolab Inc., Redmond, WA), was effective in preventing new intramammary infections (IMI) in lactating dairy cows compared with a licensed, iodophor teat disinfectant (Iosan, Novartis Animal Health, Ltd., Whittlesford, UK), and to show that the test product was tolerated equally well by teat skin. The study lasted 114 d and covered all weather conditions. The teats of 176 cows were dipped after each milking in UG Pt and the teats of 172 cows were dipped in Iosan, the positive-control product. Routine milk samples were taken from each quarter of every cow every 4 wk. Additional samples were taken from newly calved cows joining the trial and from cows with clinical signs of mastitis. Milk samples were cultured for the presence of bacteria and the cause of clinical mastitis. Each quarter was eligible for only 1 infection during the trial. The number of clinical cases was identical in each group (n = 13) and the number of subclinical infections was slightly lower in the UG Pt group than in the Iosan group (n = 27 and 31, respectively). These rates of infection suggest that the products did not differ in their ability to prevent a new IMI. At least 203 cows were assessed for skin integrity before the start of the trial and every 28 d throughout. The UG Pt teat dip had no adverse effects on teat condition. The prevalence of hyperkeratosis did not change with time for both groups (0.90 +/- 1.08 and 0.95 +/- 1.06 at wk 0 vs. 0.65 +/- 0.87 and 0.49 +/- 0.74 at wk 16 for fore and hind teats, respectively, for UG Pt and 1.02 +/- 1.25 and 1.16 +/- 1.11 at wk 0 vs. 0.51 +/- 0.71 and 0.45 +/- 0.65 at wk 16, respectively, for Iosan); no redness of the skin was observed in either group. Application of recommended statistical methods to demonstrate noninferiority was problematic.
authors.affiliation: Institute for Animal Health, Compton, Newbury, RG20 7NN, United Kingdom. eric.hillerton@dexcel.co.nz
authors.forename: J E
authors.initials: JE
authors.lastname: Hillerton
authors.forename: J
authors.initials: J
authors.lastname: Cooper
authors.forename: J
authors.initials: J
authors.lastname: Morelli
mesh_terms: D000818:Animals; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use*; D002417:Cattle; D002712:Chlorides / Q000627:therapeutic use*; D003612:Dairying / Q000379:methods*; D005260:Female; D007057:Ichthyosis / Q000662:veterinary; D007466:Iodophors / Q000627:therapeutic use; D008321:Mammary Glands, Animal / Q000382:microbiology*; D008414:Mastitis, Bovine / Q000382:microbiology / Q000517:prevention & control*; D008892:Milk / Q000382:microbiology; D012867:Skin / Q000187:drug effects; D013290:Streptococcal Infections / Q000517:prevention & control / Q000662:veterinary
chemical_list: D000891:Anti-Infective Agents, Local; D002712:Chlorides; D007466:Iodophors; C001599:chlorite