Biomonitoring of environmental estrogens in human tissues.
Two examples are presented for the application of the total effective xenoestrogen burden as biomarker of chemical exposure measured in tissue samples from patients recruited for two case-control studies. The first study focused on environmental chemicals with hormone mimicking activity, the so-called environmental estrogens, and their participation in the etiology of breast cancer. The second study investigated mother-child exposure to persistent organochlorine chemicals and assessed their combined effect on the risk of male urogenital malformations in the newborn.
Fernandez
Mariana F
MF
Laboratory Medical Investigations, University of Granada, Hospital Clinico, Granada, Spain.
Molina-Molina
Jose M
JM
Lopez-Espinosa
Maria-Jose
MJ
Freire
Carmen
C
Campoy
Cristina
C
Ibarluzea
Jesus
J
Torne
Pablo
P
Pedraza
Vicente
V
Olea
Nicolas
N
D000273:Adipose Tissue / Q000737:chemistry*; D000328:Adult; D000368:Aged; D015415:Biomarkers; D001943:Breast Neoplasms / Q000453:epidemiology; D016022:Case-Control Studies; D004781:Environmental Exposure / Q000009:adverse effects; D004784:Environmental Monitoring / Q000379:methods*; D062665:Epidemiological Monitoring; D004967:Estrogens / Q000032:analysis*; D005260:Female; D006306:Health Surveys; D006801:Humans; D006843:Hydrocarbons, Chlorinated / Q000032:analysis; D007231:Infant, Newborn; D008297:Male; D018811:Maternal Exposure; D008875:Middle Aged; D010575:Pesticides / Q000032:analysis; D010920:Placenta / Q000737:chemistry; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D013030:Spain; D014564:Urogenital Abnormalities / Q000453:epidemiology*; D015262:Xenobiotics / Q000032:analysis*
D015415:Biomarkers; D004967:Estrogens; D006843:Hydrocarbons, Chlorinated; D010575:Pesticides; D015262:Xenobiotics