Increased serum soluble CD40 levels in patients with systemic sclerosis.
OBJECTIVE
To determine serum levels of soluble CD40 (sCD40) and clinical association in patients with systemic sclerosis (SSc).


METHODS
Serum sCD40 levels were examined by ELISA in 49 patients with SSc, 15 patients with systemic lupus erythematosus, and 26 healthy individuals. sCD40 levels in plasma samples, which were obtained at the same time, were also determined. SSc patients were grouped into 22 patients with limited cutaneous SSc (lcSSc) and 27 patients with diffuse cutaneous SSc (dcSSc).


RESULTS
There was no significant difference between sCD40 levels of sera and those of plasma. Serum sCD40 levels were significantly elevated in patients with SSc compared to patients with systemic lupus erythematosus and controls (p < 0.001). Serum sCD40 levels were higher in patients with lcSSc than in those with dcSSc (p <0.001). There was no correlation between sCD40 and sCD40 ligand levels in patients with SSc.


CONCLUSIONS
Elevated serum sCD40 levels were associated with lcSSc. These results suggest that the blockade of CD40/CD40 ligand interaction could be a potential therapeutic strategy in SSc.
Komura
Kazuhiro
K
Department of Dermatology, Kanazawa University Graduate School of Medical Science, Ishikawa, Japan.
Fujimoto
Manabu
M
Matsushita
Takashi
T
Yanaba
Koichi
K
Kodera
Masanari
M
Kawasuji
Ayako
A
Hasegawa
Minoru
M
Takehara
Kazuhiko
K
Sato
Shinichi
S
D000293:Adolescent; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D019013:CD40 Antigens / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008180:Lupus Erythematosus, Systemic / Q000097:blood; D008297:Male; D008875:Middle Aged; D010949:Plasma; D012189:Retrospective Studies; D045743:Scleroderma, Diffuse / Q000097:blood* / Q000473:pathology; D045745:Scleroderma, Limited / Q000097:blood* / Q000473:pathology; D012867:Skin / Q000473:pathology
D015415:Biomarkers; D019013:CD40 Antigens