title: Anti-diarrheal activity of methanol extract of Litsea polyantha bark in mice.
abstract: The anti-diarrheal activity of methanol extract of dried bark and aerial parts of Litsea polyantha (MELP) has been evaluated in mice using different models (castor oil-induced diarrhea and propulsive gut motility in mice). MELP (50, 75, 100 mg/kg, p.o.) significantly (P<0.01) reduced the onset of diarrhea, fecal excretion and also showed a significant (P<0.001) reduction in gastrointestinal motility on charcoal meal test in mice. The results of the study support the folklore use of the plant for diarrheal remedies.
authors.affiliation: Division of Pharmacology, Department of Pharmaceutical Sciences, Birla Institute of Technology, Mesra, Ranchi (J.H.), India. biju_poonia@rediffmail.com
authors.forename: Brijendra Singh
authors.initials: BS
authors.lastname: Poonia
authors.forename: D
authors.initials: D
authors.lastname: Sasmal
authors.forename: P M
authors.initials: PM
authors.lastname: Mazumdar
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000930:Antidiarrheals / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D002368:Castor Oil; D003967:Diarrhea / Q000139:chemically induced / Q000517:prevention & control*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects*; D032862:Litsea; D008297:Male; D051379:Mice; D008517:Phytotherapy; D024301:Plant Bark; D035261:Plant Components, Aerial; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D000930:Antidiarrheals; D010936:Plant Extracts; D002368:Castor Oil