Synthesis and antibacterial activity of 4,5,6,7-tetrahydro-thieno[3,2-c]pyridine quinolones.
Synthesis and antibacterial activity of a number of substituted 4,5,6,7-tetrahydro-thieno[3,2-c]pyridine quinolones is reported. The antibacterial activities were evaluated in standard in vitro MIC assay method. Some of the compounds showed in vitro (MIC) antibacterial activity comparable to those of Gatifloxacin, Ciprofloxacin, and Sparfloxacin.
Srivastava
Brijesh Kumar
BK
Zydus Research Centre, Sarkhej-Bavla N.H. 8A, Moraiya, Ahmedabad, Gujarat 382210, India. brijeshsrivastava@zyduscadila.com
Solanki
Manish
M
Mishra
Bhupendra
B
Soni
Rina
R
Jayadev
Sanjaya
S
Valani
Darshan
D
Jain
Mukul
M
Patel
Pankaj R
PR
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000494:pharmacology; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D002939:Ciprofloxacin / Q000494:pharmacology; D015195:Drug Design; D004353:Drug Evaluation, Preclinical; D004352:Drug Resistance, Microbial; D024841:Fluoroquinolones / Q000494:pharmacology; D000077734:Gatifloxacin; D008826:Microbial Sensitivity Tests; D008956:Models, Chemical; D008968:Molecular Conformation; D011725:Pyridines / Q000737:chemistry*; D015363:Quinolones / Q000138:chemical synthesis* / Q000737:chemistry*
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D011725:Pyridines; D015363:Quinolones; D002939:Ciprofloxacin; D000077734:Gatifloxacin; C061363:sparfloxacin