Enhanced energy expenditure and fat oxidation in humans with high BMI scores by the ingestion of novel and non-pungent capsaicin analogues (capsinoids).
The biochemical and physiological indices were monitored in 44 subjects after 4-week capsinoids (capsaicin analogues with low pungency) intake. The subjects were randomly assigned to 3 groups: CSNs3 (3 mg/kg of capsinoids), CSNs10 (10 mg/kg of capsinoids) and the control (placebo). Measurements were performed in the morning on overnight-fasted subjects. The oxygen consumption (VO(2)), resting energy expenditure (REE) and fat oxidation increased slightly compared to pre-administration values without any adverse effects, although the increase was not significant. The increase in fat oxidation was positively and significantly correlated with the body mass index (BMI). A meta-analysis was therefore conducted on a subgroup consisting of subjects with BMI >or= 25 (n=28). As a result, not only VO(2) increased significantly (p<0.05) in the CSNs10 group, but also REE in the CSNs10 group and fat oxidation in the CSNs3 and CSNs10 groups tended to increase (p<0.1). Consequently, a capsinoids intake would be able to enhance the energy expenditure and fat burning in humans, particularly those with high BMI.
Inoue
Naohiko
N
Ajinomoto Research Institute for Health Fundamentals, Kawasaki-shi, Japan. naohiko_inoue@ajinomoto.com
Matsunaga
Yoshiko
Y
Satoh
Hitoshi
H
Takahashi
Michio
M
D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000502:physiology; D001827:Body Height / Q000502:physiology; D015992:Body Mass Index; D002211:Capsaicin / Q000031:analogs & derivatives* / Q000494:pharmacology*; D008076:Cholesterol, HDL / Q000097:blood; D004041:Dietary Fats / Q000378:metabolism*; D004311:Double-Blind Method; D004734:Energy Metabolism / Q000187:drug effects*; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D005740:Gases / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010084:Oxidation-Reduction; D010101:Oxygen Consumption / Q000502:physiology; D016138:Walking / Q000502:physiology
D008076:Cholesterol, HDL; D004041:Dietary Fats; D005230:Fatty Acids, Nonesterified; D005740:Gases; D005947:Glucose; D002211:Capsaicin