title: Effect of mirtazapine orally disintegrating tablets on health-related quality of life in elderly depressed patients with comorbid medical disorders: a pilot study.
abstract: BACKGROUND
  There is a need for additional studies on the quality of life (QOL) of elderly depressed subjects with medical comorbidity.
  
  
  METHODS
  We conducted a 10-week, open trial of mirtazapine orally disintegrating tablets in 16 elderly subjects with major depressive disorder and one or more serious medical illnesses. Quality of life was measured by the Medical Outcomes Study Short Form-36 Health Status Survey (SF- 36).
  
  
  RESULTS
  Treatment with mirtazapine was associated with significant reductions in clinical global impressions-severity of illness scale (CGI-S) score, the Hamilton rating scale for anxiety (HAM-A) total score, the 17-item Hamilton rating scale for depression (HAM-D) total score and the Beck depression inventory (BDI) total scores. The SF-36 "physical functioning", "role limitation physical", "vitality", "social functioning", "role limitation emotional", and "mental health" domains improved significantly. The mean mirtazapine dose at endpoint was 35 mg per day. The drug was relatively well tolerated except for three subjects who dropped out because of side effects. No drug-drug interactions or significant changes in blood pressure or heart rate occurred.
  
  
  CONCLUSIONS
  Mirtazapine orally disintegrating tablets may improve depression, insomnia, anxiety, somatic symptoms, and certain quality-of-life measures in elderly depressed subjects with medical disorders. A randomized, placebo-controlled study is warranted to confirm these promising findings.
authors.affiliation: Department of Psychiatry, Duke University Medical Center, Durham, NC 27710, USA.
authors.forename: Indira
authors.initials: I
authors.lastname: Varia
authors.forename: Srimathi
authors.initials: S
authors.lastname: Venkataraman
authors.forename: Caroline
authors.initials: C
authors.lastname: Hellegers
authors.forename: Kenneth
authors.initials: K
authors.lastname: Gersing
authors.forename: P Murali
authors.initials: PM
authors.lastname: Doraiswamy
mesh_terms: D000203:Activities of Daily Living / Q000523:psychology; D000284:Administration, Oral; D000368:Aged; D000929:Antidepressive Agents, Tricyclic / Q000008:administration & dosage* / Q000009:adverse effects; D015897:Comorbidity; D003865:Major Depressive Disorder / Q000175:diagnosis / Q000188:drug therapy* / Q000523:psychology; D004304:Dosage Forms; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D008803:Mianserin / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D008875:Middle Aged; D000078785:Mirtazapine; D010555:Personality Inventory; D010865:Pilot Projects; D011446:Prospective Studies; D011788:Quality of Life / Q000523:psychology*; D012803:Sick Role
chemical_list: D000929:Antidepressive Agents, Tricyclic; D004304:Dosage Forms; D008803:Mianserin; D000078785:Mirtazapine