title: Quantitative PCR-based screening of alpha-synuclein multiplication in multiple system atrophy.
abstract: Multiple system atrophy (MSA) is by nature a 'sporadic' disease with no evidence of familial aggregation observed. However, the alpha-synuclein locus (SNCA) multiplication families have clinically displayed parkinsonism and autonomic dysfunction. The present study did not find any SNCA multiplications in a series of 58 pathologically confirmed MSA cases excluding this event as a common cause of MSA. The question of a genetic component in MSA remains to be answered.
authors.affiliation: Department of Neuroscience, Molecular Genetics Laboratory and Core, Morris K. Udall Parkinson's Disease Research Center of Excellence, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA.
authors.forename: Sarah J
authors.initials: SJ
authors.lastname: Lincoln
authors.forename: Owen A
authors.initials: OA
authors.lastname: Ross
authors.forename: Nicole M
authors.initials: NM
authors.lastname: Milkovic
authors.forename: Dennis W
authors.initials: DW
authors.lastname: Dickson
authors.forename: Alex
authors.initials: A
authors.lastname: Rajput
authors.forename: Christopher A
authors.initials: CA
authors.lastname: Robinson
authors.forename: Spiridon
authors.initials: S
authors.lastname: Papapetropoulos
authors.forename: Deborah C
authors.initials: DC
authors.lastname: Mash
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Farrer
mesh_terms: D004252:DNA Mutational Analysis; D005260:Female; D005820:Genetic Testing / Q000379:methods; D006801:Humans; D008297:Male; D019578:Multiple System Atrophy / Q000235:genetics*; D020133:Reverse Transcriptase Polymerase Chain Reaction / Q000379:methods; D051844:alpha-Synuclein / Q000235:genetics*
chemical_list: C497604:SNCA protein, human; D051844:alpha-Synuclein