Positive expression of the immunoglobulin superfamily protein IZUMO on human sperm of severely infertile male patients.
Recently, the immunoglobulin superfamily protein IZUMO on the sperm surface was identified as being essential for sperm-egg fusion. Although we examined the expression of IZUMO on sperm of 13 male infertile patients with severe oligozoospermia and/or athenozoospermia and 12 infertile patients with fertilization failure in previous conventional IVF to determine whether it is varied in infertility patients, we could not identify any patients with IZUMO negative by immunocytochemistry.
Hayasaka
Shinichi
S
Department of Obstetrics and Gynecology, Tohoku University School of Medicine, Sendai, Miyagi, Japan.
Terada
Yukihiro
Y
Inoue
Naokazu
N
Okabe
Masaru
M
Yaegashi
Nobuo
N
Okamura
Kunihiro
K
D000328:Adult; D005786:Gene Expression Regulation / Q000502:physiology*; D006801:Humans; D007136:Immunoglobulins / Q000096:biosynthesis* / Q000235:genetics; D007248:Infertility, Male / Q000235:genetics / Q000378:metabolism*; D008297:Male; D008565:Membrane Proteins / Q000096:biosynthesis* / Q000235:genetics; D013081:Sperm Motility / Q000502:physiology; D013094:Spermatozoa / Q000378:metabolism*
C498176:IZUMO1 protein, human; D007136:Immunoglobulins; D008565:Membrane Proteins