N-methylimidazole significantly improves lipase-catalysed acylation of ribavirin.
N-methylimidazole, a molecular solvent, but also, in cationic form, a component of 1-alkyl-3-methylimidazolium ([C(n)MIM]+) ionic liquids, showed promise as an additive in accelerating remarkably transesterification catalyzed by lipase acrylic resin from Candida antarctica (CAL-B).
Liu
Bo-Kai
BK
Department of Chemistry, Zhejiang University, Hangzhou, 310027, People's Republic of China.
Wu
Qi
Q
Xu
Jian-Ming
JM
Lin
Xian-Fu
XF
D000215:Acylation / Q000187:drug effects; D000838:Anions / Q000737:chemistry; D002175:Candida / Q000201:enzymology; D002384:Catalysis / Q000187:drug effects; D007093:Imidazoles / Q000494:pharmacology*; D052578:Ionic Liquids; D008049:Lipase / Q000378:metabolism*; D015394:Molecular Structure; D012254:Ribavirin / Q000737:chemistry* / Q000378:metabolism*
D000838:Anions; D007093:Imidazoles; D052578:Ionic Liquids; D012254:Ribavirin; D008049:Lipase; C018100:1-methylimidazole