title: [Synthesis and antibacterial activity of 3-(4-amino-5-methyl-s-triazol-3-sulfanyl)-1-phenyl-propan-1-one O-(5-substituted phenyl-[1,3,4] oxadiazol-2-methyl)-oximes].
abstract: OBJECTIVE
  To study the synthetic method and antibacterial activity of amino-heterocyclic compounds coupled oxime-ether group.
  
  
  METHODS
  The treatment of 4-amino-3-methyl-5-mercapto-s-triazole (3) with beta-chlorophenyl-propanone to form amino-s-triazole sulfanylphenyl-propanone (4) sequentially followed by oximation with hydroxyl-amine to produce the oximes (5) and etherification with various oxadiazole chloromethanes (6a - j) to yield the title compounds (1a - j). The in vitro antibacterial activities of all newly synthesized compounds were tested against Gram positive bacteria and Gram negative bacteria with the standard 2-fold agar dilution method.
  
  
  RESULTS
  Twelve new compounds including two intermediates were synthesized and their structures were confirmed by IR, 1H NMR, MS and elemental analyses. The ten title compounds exhibited the potential antibacterial activities in vitro.
  
  
  CONCLUSIONS
  Theses compounds should be optimized.
authors.affiliation: Institute of Pharmacy, Henan University, Kaifeng 475001, China. hgqxy@sina.com.cn
authors.forename: Guo-Qiang
authors.initials: GQ
authors.lastname: Hu
authors.forename: Mao-Feng
authors.initials: MF
authors.lastname: Sun
authors.forename: Sheng
authors.initials: S
authors.lastname: Li
authors.forename: Wen-Long
authors.initials: WL
authors.lastname: Huang
authors.forename: Hui-Bin
authors.initials: HB
authors.lastname: Zhang
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D010069:Oxadiazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D010091:Oximes / Q000138:chemical synthesis* / Q000494:pharmacology; D014230:Triazoles / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D010069:Oxadiazoles; D010091:Oximes; D014230:Triazoles