title: Electrophysiological studies of malaria parasite-infected erythrocytes: current status.
abstract: The altered permeability characteristics of erythrocytes infected with malaria parasites have been a source of interest for over 30 years. Recent electrophysiological studies have provided strong evidence that these changes reflect transmembrane transport through ion channels in the host erythrocyte plasma membrane. However, conflicting results and differing interpretations of the data have led to confusion in this field. In an effort to unravel these issues, the groups involved recently came together for a week of discussion and experimentation. In this article, the various models for altered transport are reviewed, together with the areas of consensus in the field and those that require a better understanding.
authors.affiliation: Centre for Infection, Division of Cellular and Molecular Medicine, St. George's, University of London, London SW17 0RE, UK. hstaines@sgul.ac.uk
authors.forename: Henry M
authors.initials: HM
authors.lastname: Staines
authors.forename: Abdulnaser
authors.initials: A
authors.lastname: Alkhalil
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Allen
authors.forename: Hugo R
authors.initials: HR
authors.lastname: De Jonge
authors.forename: Elvira
authors.initials: E
authors.lastname: Derbyshire
authors.forename: Stéphane
authors.initials: S
authors.lastname: Egée
authors.forename: Hagai
authors.initials: H
authors.lastname: Ginsburg
authors.forename: David A
authors.initials: DA
authors.lastname: Hill
authors.forename: Stephan M
authors.initials: SM
authors.lastname: Huber
authors.forename: Kiaran
authors.initials: K
authors.lastname: Kirk
authors.forename: Florian
authors.initials: F
authors.lastname: Lang
authors.forename: Godfrey
authors.initials: G
authors.lastname: Lisk
authors.forename: Eugene
authors.initials: E
authors.lastname: Oteng
authors.forename: Ajay D
authors.initials: AD
authors.lastname: Pillai
authors.forename: Kempaiah
authors.initials: K
authors.lastname: Rayavara
authors.forename: Sherin
authors.initials: S
authors.lastname: Rouhani
authors.forename: Kevin J
authors.initials: KJ
authors.lastname: Saliba
authors.forename: Crystal
authors.initials: C
authors.lastname: Shen
authors.forename: Tsione
authors.initials: T
authors.lastname: Solomon
authors.forename: Serge L Y
authors.initials: SL
authors.lastname: Thomas
authors.forename: Patrick
authors.initials: P
authors.lastname: Verloo
authors.forename: Sanjay A
authors.initials: SA
authors.lastname: Desai
mesh_terms: D000818:Animals; D000838:Anions / Q000378:metabolism; D002463:Cell Membrane Permeability / Q000187:drug effects / Q000502:physiology*; D003620:Dantrolene / Q000494:pharmacology; D004912:Erythrocytes / Q000469:parasitology* / Q000502:physiology; D005665:Furosemide / Q000494:pharmacology; D006801:Humans; D007473:Ion Channels / Q000503:physiopathology; D016778:Malaria, Falciparum / Q000469:parasitology* / Q000503:physiopathology; D049990:Membrane Transport Modulators / Q000494:pharmacology; D009579:Nitrobenzoates / Q000494:pharmacology; D010084:Oxidation-Reduction; D018408:Patch-Clamp Techniques; D010963:Plasmodium falciparum / Q000502:physiology
chemical_list: D000838:Anions; D007473:Ion Channels; D049990:Membrane Transport Modulators; D009579:Nitrobenzoates; C058176:5-nitro-2-(3-phenylpropylamino)benzoic acid; D005665:Furosemide; D003620:Dantrolene