title: The inflammatory response to ischemic acute kidney injury: a result of the 'right stuff' in the 'wrong place'?
abstract: OBJECTIVE
  Ischemic acute kidney injury may be exacerbated by an inflammatory response. How injury elicits inflammation remains a major question in understanding acute kidney injury. The present review examines the hypothesis that molecules released by injured cells elicit inflammation.
  
  
  RESULTS
  After necrotic death, intracellular molecules find their way into the extracellular space. These molecules include heat shock proteins and HMGB1. Receptors for these proteins include TLR4, TLR2, CD91 and RAGE. These proinflammatory mechanisms may be so useful that nature has evolved mechanisms for programming necrotic death via poly(ADP-ribose) polymerase and cyclophilin D. In addition, apoptosis may also elicit inflammation.
  
  
  CONCLUSIONS
  The concepts discussed in this review are important for clinical medicine. Drugs and genetic manipulation may ameliorate ischemic kidney injury by regulating the inflammatory response to cell injury.
authors.affiliation: Department of Internal Medicine, Nephrology Division, UT Southwestern Medical Center, Dallas, Texas 63110, USA. christopher.lu@utsouthwestern.edu
authors.forename: Christopher Y
authors.initials: CY
authors.lastname: Lu
authors.forename: John
authors.initials: J
authors.lastname: Hartono
authors.forename: Martin
authors.initials: M
authors.lastname: Senitko
authors.forename: Jianlin
authors.initials: J
authors.lastname: Chen
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology / Q000378:metabolism*; D015703:Antigens, CD / Q000378:metabolism; D017209:Apoptosis; D006801:Humans; D007249:Inflammation / Q000378:metabolism*; D007511:Ischemia / Q000150:complications*; D007668:Kidney / Q000378:metabolism / Q000473:pathology*; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism; D009336:Necrosis / Q000378:metabolism; D011065:Poly(ADP-ribose) Polymerases / Q000378:metabolism*; D051193:Toll-Like Receptors / Q000378:metabolism
chemical_list: D015703:Antigens, CD; D051193:Toll-Like Receptors; D011065:Poly(ADP-ribose) Polymerases; D020928:Mitogen-Activated Protein Kinases