title: A quantitative morphometric study of rectal mucosa in adult and aged healthy subjects.
abstract: Rectal mucosa is relatively susceptible to pathological processes and frequently it is affected by various diseases. However, there is a notable lack of quantitative data regarding normal rectal mucosa, which would provide a reference for histoquantitative studies of the pathologically changed tissue. Therefore, we obtained the tissue from 27 healthy patients subjected to diagnostic rectoscopy during active screening for asymptomatic cancer of the large intestine, in which no disease was found. Using computer-aided morphometric analysis, we studied all structural elements of the rectal mucosa. The patients were divided into four groups according to the age and sex: adult males, elderly males, adult females and elderly females. The patients under 60 years of age were grouped as adult and those older than 60 years as aged subjects. A decreased height of surface epithelium was registered in both elderly male and female groups. This finding, however, was significant only when adult and elderly male groups were compared. The tendency towards reduction of the mucosal height was also registered comparing male adult and elderly groups. The number of crypts per 0.1 mm2 of tissue increased with aging in both males and females, whereby the crypts were always more numerous in males than in females. The increase in number of crypts in male subjects was accompanied by a decrease in their diameter and perimeter. The changes associated with ageing were discrete and affected only the male subjects.
authors.affiliation: Geriatric Clinic, Zvezdara Clinical Center, Belgrade, Serbia.
authors.forename: P D
authors.initials: PD
authors.lastname: Milosević
authors.forename: J
authors.initials: J
authors.lastname: Trbojević
authors.forename: N M
authors.initials: NM
authors.lastname: Milicević
authors.forename: D
authors.initials: D
authors.lastname: Bojić
authors.forename: M
authors.initials: M
authors.lastname: Davidović
authors.forename: P
authors.initials: P
authors.lastname: Svorcan
authors.forename: B
authors.initials: B
authors.lastname: Dapcević
authors.forename: B
authors.initials: B
authors.lastname: Bojić
authors.forename: G
authors.initials: G
authors.lastname: Mihajlović
authors.forename: Z
authors.initials: Z
authors.lastname: Milićević
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging / Q000502:physiology*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007413:Intestinal Mucosa / Q000033:anatomy & histology*; D008297:Male; D008875:Middle Aged; D012007:Rectum / Q000033:anatomy & histology*