The relationship between ABO groups and subgroups, factor VIII and von Willebrand factor.
The aim of this study was to correlate ABO groups with plasma levels of factor VIII (FVIII), von Willebrand factor (VWF:Ag), and ristocetin cofactor (VWF:RCo). Serological and molecular tests defined blood groups from 114 donors (10 AA, 10 BB, 10 AB, 10 AO1, 10 BO1,16 O1O1, 20 A2O1, 20 A2B, 4 A3O1, 3 AxO1, and 1 BelO1). The levels of VWF:Ag, FVIII and VWF:RCo observed in rare subgroups (A3O1, AxO1, BelO1) were similar to the values found in the O1O1 group. However, levels of these factors were significantly higher in A2O1 donors than in O1O1 donors (VWF:Ag p=0.01; FVIII p=0.04; VWF:RCo p<0.001). Strong correlations were demonstrated between plasma levels of VWF:Ag and FVIII (R=0.77; p=0.001) and between VWF:Ag and VWF:RCo (R=0.75; p=0.001).
Sousa
Norma Cristina
NC
Departamento de Farmacologia, State University of Campinas, UNICAMP, Campinas, Brazil.
Anicchino-Bizzacchi
Joyce Maria
JM
Locatelli
Maria Fátima
MF
Castro
Vagner
V
Barjas-Castro
Maria Lourdes
ML
D000017:ABO Blood-Group System; D051722:ADAM Proteins / Q000097:blood; D000071120:ADAMTS13 Protein; D000293:Adolescent; D000328:Adult; D000483:Alleles; D002241:Carbohydrates / Q000737:chemistry; D005169:Factor VIII / Q000096:biosynthesis*; D006579:Heterozygote; D006801:Humans; D008297:Male; D010641:Phenotype; D019851:Thrombophilia / Q000097:blood / Q000175:diagnosis; D014842:von Willebrand Diseases / Q000097:blood / Q000175:diagnosis; D014841:von Willebrand Factor / Q000096:biosynthesis*
D000017:ABO Blood-Group System; D002241:Carbohydrates; D014841:von Willebrand Factor; D005169:Factor VIII; D051722:ADAM Proteins; D000071120:ADAMTS13 Protein; C099604:ADAMTS13 protein, human