B-, T-, and NK-cell lineage involvement in JAK2V617F-positive patients with idiopathic myelofibrosis.
An acquired JAK2 (V617F)mutation has been found in myeloid cells from most patients with chronic idiopathic myelofibrosis (IM), but whether it occurs in a common myelo-lymphoid, rather than a myeloid-restricted, progenitor cell is still debated. Using a sensitive ARMS assay for the quantitative assessment of JAK2 (V617F)cDNA, we detected the mutation in purified B-, T- and NK-cells from about half of 12 patients studied. These results indicate that involvement of lymphoid lineage in IM may be more frequent than previously supposed.
Bogani
Costanza
C
Guglielmelli
Paola
P
Antonioli
Elisabetta
E
Pancrazzi
Alessandro
A
Bosi
Alberto
A
Vannucchi
Alessandro Maria
AM
D001402:B-Lymphocytes / Q000166:cytology*; D001772:Blood Cell Count; D019070:Cell Lineage; D018076:DNA, Complementary / Q000378:metabolism; D006801:Humans; D053614:Janus Kinase 2 / Q000235:genetics*; D007694:Killer Cells, Natural / Q000166:cytology*; D009154:Mutation; D055728:Primary Myelofibrosis / Q000097:blood* / Q000235:genetics*; D013601:T-Lymphocytes / Q000166:cytology*
D018076:DNA, Complementary; D053614:Janus Kinase 2