Functional site analysis in proteins of g protein signaling pathways using fuzzy evolutionary trace method.
GPCRs are physiologically significant receptors linked to numerous diseases including cardiovascular disease, mental illness, and cancer. Inhibiting the interaction between a GPCR and its G-protein blocks the ability of the receptor to initiate a signal in a cell. G Protein active sites control nearly all G protein functions and determine the interactions upon which G protein signaling pathways are built. Characterization of the active sites in G protein or GPCRs would therefore lead to new methods of controlling G proteins and ultimately controlling cells. This paper use fuzzy evolutionary trace method to analyze the binding sites of G Protein and finally give an example.
Fan
Zhang
Z
Department of Bioinformatics, Capital University of Medical Sciences.
Zhicheng
Liu
L
Xia
Li
L
Zhiwen
Gao
G
Xuan
Su
S