title: The impact of asthma exacerbations on health-related quality of life in moderate to severe asthma patients in the UK.
abstract: BACKGROUND
  The objective of this study was to report the impact of exacerbations on health-related quality of life (HRQL) and health utility in patients with moderate to severe asthma (BTS levels 4 & 5) in the UK.
  
  
  METHODS
  Prospective data regarding HRQL were collected (n=112) using the EQ-5D, mini Asthma Quality of Life Questionnaire (mAQLQ), and Asthma Symptom Utility (ASUI) measures.
  
  
  RESULTS
  The mAQLQ, EQ-5D and ASUI were all significantly worse for patients suffering exacerbations (p<0.001) compared to those without. There was also evidence of a further HRQL decrement in those patients who had been admitted to hospital as a result of an exacerbation during the four-week study.
  
  
  CONCLUSIONS
  This study documents the impact of asthma exacerbations on HRQL in patients with moderate to severe asthma. There was some evidence of floor effects on the mAQLQ and ASUI in their ability to capture the impact of exacerbations. These study data are suitable for use in economic evaluations.
authors.affiliation: United BioSource Corporation, 20 Bloomsbury Square, London WC1A 2NS, UK. andrew.lloyd@unitedbiosource.com
authors.forename: Andrew
authors.initials: A
authors.lastname: Lloyd
authors.forename: David
authors.initials: D
authors.lastname: Price
authors.forename: Ruth
authors.initials: R
authors.lastname: Brown
mesh_terms: D000328:Adult; D001249:Asthma / Q000145:classification / Q000503:physiopathology / Q000523:psychology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011788:Quality of Life; D012720:Severity of Illness Index; D006113:United Kingdom