title: Distribution of emm genotypes among group A streptococcus isolates from patients with severe invasive streptococcal infections in Japan, 2001-2005.
abstract: We surveyed emm genotypes of group A streptococcus (GAS) isolates from patients with severe invasive streptococcal infections during 2001-2005 and compared their prevalence with that of the preceding 5 years. Genotype emm1 remained dominant throughout 2001 to 2005, but the frequency rate of this type decreased compared with the earlier period. Various other emm types have appeared in recent years indicating alterations in the prevalent strains causing severe invasive streptococcal infections. The cover of the new 26-valent GAS vaccine fell from 93.5% for genotypes of isolates from 1996-2000 to 81.8% in 2001-2005.
authors.affiliation: Department of Bacteriology, National Institute of Infectious Diseases, Tokyo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Ikebe
authors.forename: K
authors.initials: K
authors.lastname: Hirasawa
authors.forename: R
authors.initials: R
authors.lastname: Suzuki
authors.forename: H
authors.initials: H
authors.lastname: Ohya
authors.forename: J
authors.initials: J
authors.lastname: Isobe
authors.forename: D
authors.initials: D
authors.lastname: Tanaka
authors.forename: C
authors.initials: C
authors.lastname: Katsukawa
authors.forename: R
authors.initials: R
authors.lastname: Kawahara
authors.forename: M
authors.initials: M
authors.lastname: Tomita
authors.forename: K
authors.initials: K
authors.lastname: Ogata
authors.forename: M
authors.initials: M
authors.lastname: Endoh
authors.forename: R
authors.initials: R
authors.lastname: Okuno
authors.forename: Y
authors.initials: Y
authors.lastname: Tada
authors.forename: N
authors.initials: N
authors.lastname: Okabe
authors.forename: H
authors.initials: H
authors.lastname: Watanabe
mesh_terms: D000942:Antigens, Bacterial / Q000235:genetics*; D001425:Bacterial Outer Membrane Proteins / Q000235:genetics*; D002352:Carrier Proteins / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D015995:Prevalence; D013290:Streptococcal Infections / Q000453:epidemiology / Q000235:genetics* / Q000382:microbiology; D013297:Streptococcus pyogenes / Q000235:genetics* / Q000302:isolation & purification
chemical_list: D000942:Antigens, Bacterial; D001425:Bacterial Outer Membrane Proteins; D002352:Carrier Proteins; C014689:streptococcal M protein