Factors associated with dopaminergic drug-related pathological gambling in Parkinson disease.
OBJECTIVE
To evaluate factors associated with pathological gambling (PG) in Parkinson disease (PD).


METHODS
Case-control study.


METHODS
Outpatient tertiary clinic. Patients Twenty-one patients with idiopathic PD with PG after the patients began receiving medications compared with a consecutive sample of 42 patients with idiopathic PD without compulsive behaviors.


METHODS
Clinical features, comorbid psychiatric and substance use disorders, personality traits, and impulsivity scores.


RESULTS
Patients with PG had a younger age at PD onset (P = .006), higher novelty seeking (P<.001), medication-induced hypomania or mania (P = .001), impaired planning (P = .002), or a personal or immediate family history of alcohol use disorders (P = .002). Novelty seeking, a personal or immediate family history of alcohol use disorders, and younger age at PD onset accurately predicted PG at 83.7% in a logistic regression model, with the model accounting for 62% of the variance.


CONCLUSIONS
Patients with PD having a younger age at PD onset, higher novelty seeking traits, and a personal or family history of alcohol use disorders may have a greater risk for PG with dopamine agonists.
Voon
Valerie
V
National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA. voonv@ninds.nih.gov
Thomsen
Teri
T
Miyasaki
Janis M
JM
de Souza
Minella
M
Shafro
Ariel
A
Fox
Susan H
SH
Duff-Canning
Sarah
S
Lang
Anthony E
AE
Zurowski
Mateusz
M
D000368:Aged; D016022:Case-Control Studies; D015259:Dopamine Agents / Q000009:adverse effects*; D005106:Exploratory Behavior; D005260:Female; D005715:Gambling; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000453:epidemiology* / Q000523:psychology*; D010555:Personality Inventory; D011569:Psychiatric Status Rating Scales; D018709:Statistics, Nonparametric
D015259:Dopamine Agents