A helping hand for cytochrome p450 enzymes.
In this issue of Cell Metabolism, Espenshade and colleagues (Hughes et al., 2007) show that the hemoprotein Dap1/PGRMC1 forms a stable complex with several members of the cytochrome P450 superfamily of enzymes and positively regulates their activities. This action indicates an important role for Dap1/PGRMC1 in P450-catalyzed reactions, some of which are involved in the metabolism of sterols and pharmaceutical compounds.
Debose-Boyd
Russell A
RA
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. russell.debose-boyd@utsouthwestern.edu
D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D015966:Gene Expression Regulation, Fungal; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism; D011485:Protein Binding; D011980:Receptors, Progesterone / Q000235:genetics / Q000378:metabolism; D012568:Schizosaccharomyces / Q000201:enzymology; D029702:Schizosaccharomyces pombe Proteins / Q000235:genetics / Q000378:metabolism
D008565:Membrane Proteins; C115296:PGRMC1 protein, human; D011980:Receptors, Progesterone; D029702:Schizosaccharomyces pombe Proteins; D003577:Cytochrome P-450 Enzyme System