Electrospun bioscaffolds that mimic the topology of extracellular matrix.
Extracellular matrix (ECM) is a natural scaffold for cell, tissue, and organ growth. Its topology plays an important role in cell differentiation. There is a design challenge to fabricate biomaterials that mimic ECM's three-dimensional (3D) structures with defined shapes and complex porous architecture. The urinary bladder matrix (UBM) is used in this work as the model system of the ECM architecture. Cellulose acetate (CA) is the biomaterial of choice for building the UBM-mimicking scaffolds. Electrospinning is the fabrication method used to form complex, porous, 3D structures with specific design, in a single-step process.
Han
Dong
D
Department of Materials Science and Engineering, State University of New York, Stony Brook, New York, USA.
Gouma
Pelagia-Irene
PI
D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D040761:Biomimetic Materials / Q000737:chemistry*; D018929:Cell Culture Techniques / Q000379:methods*; D002482:Cellulose / Q000031:analogs & derivatives / Q000737:chemistry; D004563:Electrochemistry / Q000379:methods; D005109:Extracellular Matrix / Q000737:chemistry*; D008422:Materials Testing; D010316:Particle Size; D012399:Rotation; D013499:Surface Properties; D013552:Swine; D023822:Tissue Engineering / Q000379:methods*; D001743:Urinary Bladder / Q000737:chemistry*
D001672:Biocompatible Materials; C005062:acetylcellulose; D002482:Cellulose