MRI of the breast for the detection and assessment of the size of ductal carcinoma in situ.
OBJECTIVE
The aim of the study was to compare the accuracy of magnetic resonance imaging (MRI) and mammography for the detection and assessment of the size of ductal carcinoma in situ (DCIS).


METHODS
The preoperative contrast-enhanced MRI and mammography were analyzed in respect of the detection and assessment of the size of DCIS in 72 patients (age range: 30-67 years, mean age: 47 years). The MRI and mammographic measurements were compared with the histopathologic size with using the Pearson's correlation coefficients and the Mann-Whitney u test. We evaluated whether the breast density, the tumor nuclear grade, the presence of comedo necrosis and microinvasion influenced the MRI and mammographic size estimates by using the chi-square test.


RESULTS
Of the 72 DCIS lesions, 68 (94%) were detected by MRI and 62 (86%) were detected by mammography. Overall, the Pearson's correlation of the size between MRI and histopathology was 0.786 versus 0.633 between mammography and histopathology (p < 0.001). MRI underestimated the size by more than 1 cm (including false negative examination) in 12 patients (17%), was accurate in 52 patients (72%) and overestimated the size by more than 1 cm in eight patients (11%) whereas mammography underestimated the size in 25 patients (35%), was accurate in 31 patients (43%) and overestimated the size in 16 patients (22%). The MRI, but not the mammography, showed significant correlation for the assessment of the size of tumor in noncomedo DCIS (p < 0.001 vs p = 0.060). The assessment of tumor size by MRI was affected by the nuclear grade (p = 0.008) and the presence of comedo necrosis (p = 0.029), but not by the breast density (p = 0.747) or microinvasion (p = 0.093).


CONCLUSIONS
MRI was more accurate for the detection and assessment of the size of DCIS than mammography.
Kim
Do Youn
DY
Department of Radiology, Institute of Radiation Medicine, University Medical Research Center, College of Medicine Seoul National University, Seoul 110-744, Korea.
Moon
Woo Kyung
WK
Cho
Nariya
N
Ko
Eun Sook
ES
Yang
Sang Kyu
SK
Park
Jeong Seon
JS
Kim
Sun Mi
SM
Park
In-Ae
IA
Cha
Joo Hee
JH
Lee
Eun Hye
EH
D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000175:diagnosis*; D002278:Carcinoma in Situ / Q000175:diagnosis*; D018270:Carcinoma, Ductal, Breast / Q000175:diagnosis*; D016009:Chi-Square Distribution; D003287:Contrast Media; D003937:Diagnosis, Differential; D019786:Gadolinium DTPA; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008327:Mammography; D008875:Middle Aged; D009367:Neoplasm Staging; D012189:Retrospective Studies
D003287:Contrast Media; D019786:Gadolinium DTPA