[Expression of PCNA, VEGF and bFGF in endothelial cells of juvenile nasopharyngeal angiofibroma].
OBJECTIVE
To investigate the nature of juvenile nasopharyngeal angiofibroma (JNA).


METHODS
The difference of PCNA, VEGF and bFGF expression between hemangioma and vascular malformation in children and infant was applied to this study. 25 cases of JNA,10 cases of hemangioma and 11 cases of vascular malformation were studied respectively by immunohistochemical methods.


RESULTS
The PCNA and VEGF expression in the endothelial cells of JNA were negative, the PCNA and VEGF expression in the endothelial cells of haemangioma were positive, the PCNA and VEGF expression in the endothelial cells of vascular malformation were negative, there were extraordinary significant difference between the group of JNA and haemangioma (P < 0.01). There were no significant difference between the group of JNA and vascular malformation ( P > 0.05). The bFGF expression in the endothelial cells of JNA was positive, the bFGF expression in the endothelial cells of haemangioma was positive, the bFGF expression in the endothelial cells of vascular malformation was negative, there were no significant difference between the group of JNA and haemangioma (P > 0.05). There were extraordinary significant difference between the group of JNA and vascular malformation (P < 0.01).


CONCLUSIONS
The nature of JNA could be a congenital proliferative vascular malformation.
Sun
Yi
Y
Department of Otorhinolaryngology, General Hospital of Guangzhou Military Command, Guangzhou 430070, Chin. jjs70@sohu.com
Wu
Zhanyuan
Z
D000293:Adolescent; D000328:Adult; D018322:Angiofibroma / Q000378:metabolism*; D042783:Endothelial Cells / Q000378:metabolism*; D004730:Endothelium, Vascular / Q000166:cytology; D005346:Fibroblast Growth Factors / Q000378:metabolism*; D006801:Humans; D008297:Male; D009303:Nasopharyngeal Neoplasms / Q000378:metabolism*; D018809:Proliferating Cell Nuclear Antigen / Q000378:metabolism*; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism*; D055815:Young Adult
D018809:Proliferating Cell Nuclear Antigen; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; C108111:fibroblast growth factor 13; D005346:Fibroblast Growth Factors