title: Campylobacter jejuni-induced acute transverse myelitis.
abstract: METHODS
  Case report.
  
  
  METHODS
  University Hospital of Antwerp, tertiary referral hospital of the University of Antwerp, Edegem, Belgium.
  
  
  METHODS
  Campylobacter jejuni infection is related to various syndromes in which the peripheral nervous system is involved. An immune response is triggered through molecular mimicry between gangliosides of the peripheral nervous system and lipo-oligosaccharides of C. jejuni. We report a case of a previously healthy 17-year-old girl, who developed clinical manifestations of acute transverse myelitis (ATM) 7 days after a culture-proven C. jejuni enteritis. High titres of serum IgG antibodies to the ganglioside GM1 were found in the acute phase of disease, which decreased with clinical recovery. These antibodies cross-reacted with C. jejuni lipo-oligosaccharides, indicating that C. jejuni infections may induce ATM.
  
  
  CONCLUSIONS
  Only a few cases of C. jejuni infection associated with demyelination of the central nervous system or spinal cord have been described. Physicians should be aware that C. jejuni might be another cause of transverse myelitis.
authors.affiliation: Department of Neurology, University Hospital of Antwerp, Edegem, Belgium.
authors.forename: I
authors.initials: I
authors.lastname: Baar
authors.forename: B C
authors.initials: BC
authors.lastname: Jacobs
authors.forename: N
authors.initials: N
authors.lastname: Govers
authors.forename: P G
authors.initials: PG
authors.lastname: Jorens
authors.forename: P M
authors.initials: PM
authors.lastname: Parizel
authors.forename: P
authors.initials: P
authors.lastname: Cras
mesh_terms: D000293:Adolescent; D000907:Antibodies, Bacterial / Q000097:blood; D000942:Antigens, Bacterial / Q000276:immunology; D001426:Bacterial Proteins / Q000276:immunology; D001921:Brain / Q000276:immunology / Q000473:pathology; D002169:Campylobacter Infections / Q000097:blood / Q000150:complications* / Q000276:immunology; D016123:Campylobacter jejuni / Q000276:immunology; D003429:Cross Reactions; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005677:G(M1) Ganglioside / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D008070:Lipopolysaccharides / Q000276:immunology; D008279:Magnetic Resonance Imaging; D018716:Molecular Mimicry; D009188:Myelitis, Transverse / Q000276:immunology* / Q000382:microbiology* / Q000503:physiopathology*; D013116:Spinal Cord / Q000276:immunology / Q000473:pathology
chemical_list: D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D001426:Bacterial Proteins; D007074:Immunoglobulin G; D008070:Lipopolysaccharides; C023023:lipid-linked oligosaccharides; D005677:G(M1) Ganglioside