Kolokosides A-D: triterpenoid glycosides from a Hawaiian isolate of Xylaria sp.
Four new triterpenoid glycosides, kolokosides A-D (1-4), along with the known compound 19,20-epoxycytochalasin N, were isolated from cultures of a Hawaiian wood-decay fungus (Xylaria sp.). The structures and relative configurations of 1-4 were determined primarily by analysis of NMR data, and the absolute configuration of 1 was assigned by application of the exciton chirality method. Compound 1 exhibited activity against Gram-positive bacteria.
Deyrup
Stephen T
ST
Department of Chemistry, University of Iowa, Iowa City, IA 52242, USA.
Gloer
James B
JB
O'Donnell
Kerry
K
Wicklow
Donald T
DT
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001412:Bacillus subtilis / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D005947:Glucose / Q000032:analysis; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D006254:Hawaii; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D013211:Staphylococcus aureus / Q000187:drug effects; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013098:Xylariales / Q000737:chemistry*
D000900:Anti-Bacterial Agents; D006027:Glycosides; D014315:Triterpenes; D005947:Glucose