[Oral bacteria and periodontitis, with special reference to innate immune system in oral mucosa].
Innate immune system is an ubiquitous system from insects to human and responsible for initial host defense against invasive pathogens, where pathogen-associated molecular patterns (PAMPs) are recognized by the pattern recognition molecules of hosts. Representative human receptors for PAMPs are nine Toll-like receptors (TLRs) and intracellular NOD molecules which recognize peptidoglycans of bacterial cell-walls. Oral epithelial cells express various TLRs and NODs so far examined, and these cells in normal condition produce antibacterial factors, but not proinflammatory factors, in response to various PAMPs to prevent bacterial invasion without excessive inflammatory responses.
Uehara
Akiko
A
Tohoku University Graduate School of Dentistry, Department of Microbiology and Immunology.
Takada
Haruhiko
H
D000818:Animals; D001419:Bacteria / Q000276:immunology; D002352:Carrier Proteins; D006801:Humans; D007113:Immunity, Innate; D009061:Mouth Mucosa / Q000276:immunology* / Q000382:microbiology*; D053474:Nod1 Signaling Adaptor Protein / Q000276:immunology; D053473:Nod2 Signaling Adaptor Protein / Q000276:immunology; D010457:Peptidoglycan / Q000276:immunology; D010518:Periodontitis / Q000276:immunology* / Q000382:microbiology*; D051193:Toll-Like Receptors / Q000276:immunology*; D023083:beta-Defensins
D002352:Carrier Proteins; C106641:DEFB4A protein, human; D053474:Nod1 Signaling Adaptor Protein; D053473:Nod2 Signaling Adaptor Protein; D010457:Peptidoglycan; D051193:Toll-Like Receptors; D023083:beta-Defensins; C118897:peptidoglycan recognition protein