The Characterization and Imaging Behavior of a New Developed Paramagnetic Contrast Agent NMG2[Gd(TTDA-BOM)].
[Gd(TTDA-BOM)]2-is a newly developed paramagnetic contrast agent.The ligand,TTDA-BOM,bears a benzyloxymethyl group so that the lipophilicity is increased. The water exchange rate for [Gd(TTDA-BOM)]2-is significantly higher than that of [Gd(DTPA)]2-and [Gd(BOPTA)]2-.In addition, the bound relaxivity of this Gd (III) complex has a remarkably high value with HSA. Therefore,it has potential to be used as a blood pool contrast agent for MRI. The aim of this study is to investigate the characterization and imaging behavior of NMG<inf>2</inf>[Gd(TTDA-BOM)] in normal rat livers and hearts using a 3T high field whole-body MR scanner.The high field MR scanner is expected to have a higher signal to noise ratio. The relaxivities r<inf>1</inf>and r<inf>2</inf>for [Gd(TTDA-BOM)]2-at 3T are 5.97 mM-1s-1and 7.99 mM-1s-1respectively, which are higher than those for [Gd(DTPA)]2(r1=4.64 mM-1s-1and r<inf>2</inf>= 5.08 mM-1s-1). The dynamic MRI studies show that there is marked enhancement in livers and hearts right after the bolus injection and the enhancement ratios keep high until two hours. In conclusion, [Gd(TTDA-BOM)]2-might have a good potential in both cardiovascular and hepatobiliary applications.
Jao
Jo-Chi
JC
Faculty of Radiological Sciences, Kaohsiung Medical University, Kaohsiung, Taiwan.
Wang
Yun-Ming
YM
Ou
Ming-Hung
MH
Hsie Chen
Shih
S
Chen
Yen-Ku
YK
Jaw
Twei-Shiun
TS
Liu
Gin-Chung
GC
Chen
Po-Chou
PC