title: Neural Probes for Concurrent Detection of Neurochemical and Electrophysiological Signals in vivo.
abstract: Electrochemical sensing with microelectrode arrays provides a means for monitoring neurotransmitter dynamics across multiple locations within a micro-scale region of brain tissue. Here we present a multi-modal neural probe design for concurrent recording of neurochemical and electrophysiological signals in vivo. Prior to implantation, platinum sites on each array underwent platinum-black electroplating and Nafion electropolymerization, which increased sensitivity to dopamine by 74% and decreased sensitivity to common interferents by at least 89%. In a series of three rats, we applied various electrochemical waveforms to platinum sites and monitored neural activity on adjacent iridium sites. We found that chronoamperometry and constant-potential amperometry did not alter firing rates at +0.25, +0.50, and +0.75 V. In addition, we have demonstrated multi-modal recordings of striatal neurons in response to medial forebrain bundle stimulation.
authors.affiliation: Department of Biomedical Engineering, University of Michigan, MI, USA.
authors.forename: M
authors.initials: M
authors.lastname: Johnson
authors.forename: R
authors.initials: R
authors.lastname: Franklin
authors.forename: K A
authors.initials: KA
authors.lastname: Scott
authors.forename: R
authors.initials: R
authors.lastname: Brown
authors.forename: D
authors.initials: D
authors.lastname: Kipke