[Allelic variants of genes: angiotensin I-converting enzyme (ACE), angiotensin-II type 1 receptor (AT1R), methylenetetrahydrofolate reductase and left ventricular mass in patients with myocardial infarction].
BACKGROUND
Ischemic heart disease has a complex etiology apparently involving gene polymorphisms in the renin-angiotensin system. I/D ACE, A11166C AT1R and C677T MTHFR polymorphisms seem to be associated with a higher risk of myocardial infarction. The aim of this study was to establish the distribution of ACE, AT1R and MTHFR genotypes, and search for correlations with left ventricular anatomic measurements in Polish patients with a history of myocardial infarction. INVESTIGATED GROUP AND METHOD: Our study group comprised 100 patients (14 females and 86 males, aged 54.2 +/- 9.2 years) and 100 age-matched controls (10 females and 90 males, aged 52.3 +/- 10.0 years). We used PCR and PRC-RFLP to detect ACE I/D, AT1RAl 166C and MTHFR C677T gene polymorphisms, respectively.


RESULTS
Distribution of individual genotypes did not differ significantly ACE, AT1R, MTHFR in study vs. control groups. No association between ACE, AT1R or MTHFR genotypes and left ventricular mass was found.


CONCLUSIONS
Our results suggest that polymorphisms of the ACE, AT1R and MTHFR genes do not predispose to myocardial infarction and higher left ventricular mass in the Polish population.
Goracy
Jarosław
J
Katedra Diagnostyki Laboratoryjnej.
Peregud-Pogorzelska
Małgorzata
M
Goracy
Iwona
I
Kaczmarczyk
Mariusz
M
Kornacewicz-Jach
Zdzisława
Z
Naruszewicz
Marek
M
Ciechanowicz
Andrzej
A
D000483:Alleles; D005260:Female; D005787:Gene Frequency; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000235:genetics*; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D008875:Middle Aged; D009203:Myocardial Infarction / Q000235:genetics*; D009929:Organ Size / Q000235:genetics; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011044:Poland; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D044140:Receptor, Angiotensin, Type 1 / Q000235:genetics*; D012016:Reference Values
D044140:Receptor, Angiotensin, Type 1; D042965:Methylenetetrahydrofolate Reductase (NADPH2); D007703:Peptidyl-Dipeptidase A