title: Design proposal of imaging activities of cultured neural network on a silicon substrate with neural-electronic-optical integrated microsystem.
abstract: Multielectrode Arrays have currently been widely used as Neural-Network research tools. In this paper, we propose a novel mixed integrated sensor array microsystem combining cultured biological neurons, silicon integrated circuits and optical components together on a single silicon substrate. Using the light emitting property of GaAs-LED dependent on current passing from the recorded action potentials signals by a Multielectrode-Array in situ, we are able to characterize the neural activities of the cultured neural networks directly with a visible image displayed by a monitoring CCD Camera. Researchers may use various ready image process tools for experimental data analysis to directly observe results.
authors.affiliation: Department of Electronic Engineering, Tsinghua University, Beijing, 100084, P.R. China.
authors.forename: Chao
authors.initials: C
authors.lastname: Bian
authors.forename: Xindong
authors.initials: X
authors.lastname: Song
authors.forename: Zihong
authors.initials: Z
authors.lastname: Liu
authors.forename: Hanyi
authors.initials: H
authors.lastname: Zhang