Treatment of cutaneous T-cell lymphoma/mycosis fungoides.
The cause of mycosis fungoides is unknown and, with the possible exception of very early stage disease, no cure is available. Fortunately, patients with MF have a number of therapeutic options and partial and complete remissions are achievable. Because it is not curable, the burden for patients with this disease involves the need for lifelong therapy and monitoring, and meticulous skin care. Despite its indolent nature in most individuals, the disease has a tremendous psychological impact, not only because of the visible nature of the skin lesions, but also due to the rarity of the disease and its chronicity. Knowledge of this disease, therapeutic options, and expectations of therapy will enhance care of patients afflicted with mycosis fungoides. Ongoing research provides hope that in the future, therapy to induce long-lasting remission, or even cure, will become available. Since the submission of this manuscript, vorinostat (Zolinza), an orally administered histone inhibitor, has been FDA approved for treating skin manifestations in patients with CTCL.
Parker
Sareeta R S
SR
Department of Dermatology, Emory University, Atlanta, GA, USA.
Bradley
Bridget
B
D000279:Administration, Cutaneous; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use; D000077610:Bexarotene; D001706:Biopsy; D017281:Cost of Illness; D004167:Diphtheria Toxin / Q000627:therapeutic use; D005582:Foundations; D006801:Humans; D006877:Hydroxamic Acids / Q000627:therapeutic use; D007372:Interferons / Q000627:therapeutic use; D007376:Interleukin-2 / Q000627:therapeutic use; D008466:Mechlorethamine / Q000627:therapeutic use; D009182:Mycosis Fungoides / Q000175:diagnosis* / Q000523:psychology / Q000628:therapy*; D009367:Neoplasm Staging; D017893:Photopheresis; D010789:Phototherapy; D010808:Physical Examination; D011878:Radiotherapy; D011993:Recombinant Fusion Proteins / Q000627:therapeutic use; D012176:Retinoids / Q000627:therapeutic use; D012657:Self-Help Groups; D017592:Skin Care / Q000379:methods; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000523:psychology / Q000628:therapy*; D013764:Tetrahydronaphthalenes / Q000627:therapeutic use; D000077337:Vorinostat
D000893:Anti-Inflammatory Agents; D000970:Antineoplastic Agents; D004167:Diphtheria Toxin; D006877:Hydroxamic Acids; D007376:Interleukin-2; D011993:Recombinant Fusion Proteins; D012176:Retinoids; D013764:Tetrahydronaphthalenes; C078456:denileukin diftitox; D008466:Mechlorethamine; D000077337:Vorinostat; D007372:Interferons; D000077610:Bexarotene