title: The magnetic susceptibilities of iron deposits in thalassaemic spleen tissue.
abstract: The iron-specific magnetic susceptibility of tissue iron deposits is used in the field of non-invasive measurement of tissue iron concentrations. It has generally been assumed to be a constant for all tissue and disease types. The iron-specific magnetic susceptibilities chi(Fe) for spleen tissue samples from 7 transfusion dependent beta-thalassaemia (beta-thal) patients and 11 non-transfusion dependent beta-thalassaemia/Haemoglobin E (beta/E) patients were measured at 37 degrees C. Both groups of patients were iron loaded with no significant difference in the distribution of spleen iron concentrations between the two groups. There was a significant difference between the mean chi(Fe) of the spleen tissue from each group. The non-transfusion dependent beta/E patients had a higher mean (+/-standard deviation) spleen chi(Fe) (1.55+/-0.23 x 10(-6) m(3)/kg Fe) than the transfusion dependent beta-thal patients (1.16+/-0.25 x 10(-6) m(3)/kg Fe). Correlations were observed between chi(Fe) of the spleen tissue and the fraction of magnetic hyperfine split sextet in the (57)Fe Mössbauer spectra of the tissues at 78 K (Spearman rank order correlation r=-0.54, p=0.03) and between chi(Fe) of the spleen tissue and the fraction of doublet in the spectra at 5 K (r=0.58, p=0.02) indicating that chi(Fe) of the spleen tissue is related to the chemical speciation of the iron deposits in the tissue.
authors.affiliation: School of Physics, Mailbox M013, The University of Western Australia, 35 Stirling Highway, Crawley, WA 6009, Australia.
authors.forename: S
authors.initials: S
authors.lastname: Hackett
authors.forename: W
authors.initials: W
authors.lastname: Chua-anusorn
authors.forename: P
authors.initials: P
authors.lastname: Pootrakul
authors.forename: T G
authors.initials: TG
authors.lastname: St Pierre
mesh_terms: D006801:Humans; D007501:Iron / Q000032:analysis*; D008280:Magnetics; D015204:Spectroscopy, Mossbauer; D013154:Spleen / Q000737:chemistry*; D017086:beta-Thalassemia / Q000378:metabolism*
chemical_list: D007501:Iron