Intracellular pH sensors: design principles and functional significance.
Changes in intracellular pH regulate many cell behaviors, including proliferation, migration, and transformation. However, our understanding of how physiological changes in pH affect protein conformations and macromolecular assemblies is limited. We present design principles, current modeling predictions, and examples of pH sensors or proteins that have activities or ligand-binding affinities that are regulated by changes in intracellular pH.
Srivastava
Jyoti
J
Department of Cell and Tissue Biology, Unicversity of California-San Francisco, San Francisco, CA, USA.
Barber
Diane L
DL
Jacobson
Matthew P
MP
D000136:Acid-Base Equilibrium / Q000502:physiology; D000818:Animals; D003598:Cytoskeletal Proteins / Q000737:chemistry* / Q000502:physiology*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D011487:Protein Conformation; D011956:Receptors, Cell Surface / Q000737:chemistry* / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology; D013329:Structure-Activity Relationship
D003598:Cytoskeletal Proteins; D011956:Receptors, Cell Surface