The current role of calcineurin inhibitors in posttransplant immunosuppression?
It is important to determine when to use and when to avoid calcineurin inhibitors (CNIs). CNIs are associated with kidney dysfunction in some, but not all, transplant recipients. CNI-sparing protocols have their own drug-specific limitations. Two major clinical series suggest the benefit of routine CNI-sparing approaches, but our review suggests weaknesses in both. Ongoing studies are needed to determine which subgroups of recipients will benefit from CNIs.
Matas
A J
AJ
Department of Surgery, University of Minnesota, Minneapolis, Minnesota, USA. matas001@umn.edu
Kandaswamy
R
R
D065095:Calcineurin Inhibitors; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000627:therapeutic use*; D016030:Kidney Transplantation / Q000276:immunology; D014181:Transplantation Immunology
D065095:Calcineurin Inhibitors; D007166:Immunosuppressive Agents