Vaccine delivery methods using viral vectors.
Viral vectors have different capabilities as gene delivery vehicles for vaccines and immunotherapeutics. This review discusses selected viral vector systems and plasmid DNA and provides an overview of their specific characteristics, strengths, and limitations. The features, modes of viral entry and replication, expression of heterologous proteins, issues related to both preexisting and heterologous immunity, and vaccine strategies are discussed for the different vectors. Comparisons of the features and capabilities of the vectors are provided.
Bråve
Andreas
A
Swedish Institute for Infectious Disease Control and Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, 171 82 Stockholm, Sweden.
Ljungberg
Karl
K
Wahren
Britta
B
Liu
Margaret A
MA
D000818:Animals; D004279:DNA, Viral / Q000378:metabolism*; D016503:Drug Delivery Systems; D005822:Genetic Vectors; D006801:Humans; D019444:Vaccines, DNA / Q000008:administration & dosage* / Q000276:immunology*; D014780:Viruses
D004279:DNA, Viral; D019444:Vaccines, DNA