Synthesis and characterization of hexa-tailed cryptand based amphiphiles: spontaneous formation of giant vesicular microcapsule with efficient and long-term dye encapsulation.
A cryptand with six secondary amino groups has been derivatized by reacting with acid chlorides of different chain lengths (C(7), C(10) and C(18)) to get three cryptand based hexa-tailed neutral amphiphiles (L(1)-L(3)). The cavity of the cryptand head group accommodates two Cu(II) ion giving another set of three amphiphiles. These amphiphiles and its copper complexes can aggregate spontaneously as giant vesicular microcapsules in 10% ethanolic water medium. In all cases vesicles formed are mostly unilamellar in nature. Vesicular microcapsules prepared from L(1)-L(3) can encapsulate hydrophilic dye 5(6)-carboxyfluorescein (CF). Stability of microcapsules, CF encapsulation efficiencies and release rates were dependent on the hydrophobic chain length of the amphiphiles. Results show the permeability of the L(2) and L(3) bilayer is lower than that of phosphatidylcholine vesicles and the loading capacity is approximately 3 times greater. Microcapsules have been characterized by optical microscopy, freeze fracture scanning electron microscopy and confocal fluorescence microscopy.
Bandyopadhyay
Prasun
P
Unilever Research India and Hindustan Lever Research Centre, 64 Main Road, Whitefield, Bangalore 560066, India. prasun.bandyopadhyay@unilever.com
Bhunia
Prasenjit
P
D002214:Capsules / Q000138:chemical synthesis*; D003102:Colloids / Q000737:chemistry; D043844:Crown Ethers / Q000138:chemical synthesis; D005614:Freeze Fracturing; D018613:Microscopy, Confocal; D013501:Surface-Active Agents / Q000737:chemistry*
D002214:Capsules; D003102:Colloids; D043844:Crown Ethers; D013501:Surface-Active Agents