Investigation of interactions between two monoclonal antibodies and SARS virus with a Label-free Protein Array.
The investigation of interactions between two kinds of monoclonal antibodies and SARS virus with a label-free protein array technique were presented in this paper. The performance consists of three parts: a surface modification for ligand immobilization/surface, a protein array fabrication with an integrated microfluidic system for patterning, packaging and liquid handling, and a protein array reader of imaging ellipsometer. This revealed the technique could be used as an immunoassay for qualitative and quantitative detection as well as kinetic analysis of biomolecule interaction.
Qi
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Institute of Mechanics, Chinese Academy of Sciences, #15, Bei-si-huan West Rd., Beijing 100080, P.R.China; Graduate School of Chinese Academy of Sciences, #19, Yu-quan Rd, Shi-jing-shan District, Beijing 100039, P.R.China.
Chen
Y-Y
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Wang
Z-H
ZH
Jin
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