Micromanaging alternative splicing during muscle differentiation.
A recent report in Genes & Development by Boutz et al. (2007) demonstrates that muscle specific microRNAs (miRNAs) downregulate the alternative splicing regulator nPTB during skeletal muscle differentiation to control a potential network of splicing transitions. The results illustrate how two modes of posttranscriptional regulation combine to direct skeletal muscle development.
Bland
Christopher S
CS
Department of Pathology, Baylor College of Medicine, Houston, TX 77030, USA.
Cooper
Thomas A
TA
D017398:Alternative Splicing / Q000235:genetics*; D000818:Animals; D002454:Cell Differentiation / Q000235:genetics*; D051379:Mice; D035683:MicroRNAs / Q000235:genetics; D024510:Muscle Development / Q000235:genetics*; D018482:Muscle, Skeletal / Q000166:cytology*; D038941:Polypyrimidine Tract-Binding Protein / Q000235:genetics / Q000378:metabolism
D035683:MicroRNAs; D038941:Polypyrimidine Tract-Binding Protein