title: Sapogenin levels in Narthecium ossifragum plants and Ovis aries lamb faeces during two alveld outbreaks in Møre og Romsdal, Norway, 2001.
abstract: The proposal that saponins produced by the lily bog asphodel (Narthecium ossifragum) may be the direct cause of the hepatogenous photosensitization disease alveld seen in Norwegian lambs was investigated by comparing sapogenin levels in two control and two toxic pastures, and in faeces from lambs grazing the four pastures in the Halsa and Surnadal municipalities, Møre og Romsdal county, Norway. Generally similar levels of sapogenins, determined after hydrolysis of parent plant saponins, were found in Narthecium leaves collected in June/July 2001 from the two alveld outbreak areas and two nearby control areas. Differences in the median sapogenin levels determined for leaf samples in outbreak and control areas were not statistically significant. The total level of free and conjugated sapogenins in faeces recovered from the rectums of lambs grazing the outbreak and control pastures areas varied greatly. The results obtained do not support the hypothesis that a dose-response relationship exists between Narthecium saponin levels and the occurrence of alveld outbreaks.
authors.affiliation: Department of Biology, University of Oslo, Oslo, Norway. ivar.mysterud@bio.uio.no
authors.forename: I
authors.initials: I
authors.lastname: Mysterud
authors.forename: A
authors.initials: A
authors.lastname: Flåøyen
authors.forename: J I
authors.initials: JI
authors.lastname: Loader
authors.forename: A L
authors.initials: AL
authors.lastname: Wilkins
mesh_terms: D000818:Animals; D027743:Dioscoreaceae / Q000737:chemistry / Q000633:toxicity*; D005243:Feces / Q000737:chemistry; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods; D019684:Magnoliopsida / Q000737:chemistry / Q000633:toxicity*; D009664:Norway; D010787:Photosensitivity Disorders / Q000139:chemically induced / Q000662:veterinary*; D018515:Plant Leaves / Q000737:chemistry / Q000633:toxicity; D012502:Sapogenins / Q000032:analysis / Q000633:toxicity*; D012756:Sheep; D012757:Sheep Diseases / Q000139:chemically induced*
chemical_list: D012502:Sapogenins