Ankle position and voluntary contraction alter maximal M waves in soleus and tibialis anterior.
Compound muscle action potentials (CMAPs) recorded using surface electrodes are often used to assess the excitability of neural pathways to skeletal muscle. However, the amplitude of CMAPs can be influenced by changes at the recording site, independent of mechanisms within the central nervous system. We quantified how joint angle and background contraction influenced CMAP amplitude. In seven subjects CMAPs evoked by supramaximal transcutaneous electrical stimulation of motor axons (M(max)) were recorded using surface electrodes from soleus and tibialis anterior (TA) at static positions over the full range of ankle movement at 5 degrees intervals. Across subjects the peak-to-peak amplitude of M(max) was 155% and 159% larger at the shortest than longest muscle lengths for soleus and TA, respectively. In five subjects the effect of ankle position and voluntary contraction on M-wave/H-reflex recruitment curves was assessed in the soleus. Both ankle position and level of contraction significantly influenced M(max), H(max), and the H(max) to M(max) ratio, but there were no interactions between the two parameters. These peripheral changes that influence M(max) will also impact other CMAPs such as submaximal M-waves, H-reflexes, and responses to transcranial magnetic stimulation. As such, during experimental studies CMAPs evoked at a given joint angle and contraction level should be normalized to M(max) recorded at similar joint angle and contraction strength.
Frigon
Alain
A
Centre for Research in Neurological Sciences, Department of Physiology, Université de Montréal, Montréal, Québec, Canada.
Carroll
Timothy J
TJ
Jones
Kelvin E
KE
Zehr
E Paul
EP
Collins
David F
DF
D000200:Action Potentials / Q000502:physiology*; D000328:Adult; D000842:Ankle / Q000502:physiology*; D004558:Electric Stimulation; D004566:Electrodes / Q000592:standards; D004576:Electromyography / Q000295:instrumentation / Q000379:methods / Q000592:standards; D006801:Humans; D009046:Motor Neurons / Q000502:physiology; D009119:Muscle Contraction / Q000502:physiology*; D018482:Muscle, Skeletal / Q000502:physiology*; D009431:Neural Conduction / Q000502:physiology; D011187:Posture / Q000502:physiology*; D011237:Predictive Value of Tests; D011434:Proprioception / Q000502:physiology; D016059:Range of Motion, Articular / Q000502:physiology*; D014836:Volition