title: Treatment of Tacrolimus-associated thrombotic microangiopathy in renal transplant recipient with fresh frozen plasma: A case report.
abstract: PThrombotic microangiopathy (TMA) is a rare serious adverse reaction of calcineurin inhibitors, tacrolimus and cyclosporin. We report a case of a young male renal transplant recipient treated with tacrolimus, who developed TMA. Treatment included discontinuation of tacrolimus, increasing the dose of mycophenolate mofetil and infusion of fresh-frozen plasma. This was followed by normalization of renal function and dis-appearance of proteinuria. The remission has been sustained after a follow-up of nine months.
authors.affiliation: Unit of Nephrology, Military Hospital of Tunis, Tunisia.
authors.forename: Harzallah
authors.initials: H
authors.lastname: Kais
authors.forename: Cherif
authors.initials: C
authors.lastname: Nourredine
authors.forename: Belhadj
authors.initials: B
authors.lastname: Raoudha
authors.forename: Chelbi
authors.initials: C
authors.lastname: Emira
authors.forename: Sraeib
authors.initials: S
authors.lastname: Tarek
authors.forename: Saddek
authors.initials: S
authors.lastname: Fehmi
authors.forename: Boussema
authors.initials: B
authors.lastname: Ezzedine
authors.forename: Hmida
authors.initials: H
authors.lastname: Jalel
authors.forename: Manaa
authors.initials: M
authors.lastname: Jamel
mesh_terms: D016572:Cyclosporine / Q000627:therapeutic use; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D016030:Kidney Transplantation; D016559:Tacrolimus / Q000627:therapeutic use; D057049:Thrombotic Microangiopathies
chemical_list: D007166:Immunosuppressive Agents; D016572:Cyclosporine; D016559:Tacrolimus