Lack of effect of short-term diazoxide administration on luteinizing hormone secretion in women with polycystic ovary syndrome.
OBJECTIVE
To test the hypothesis that an acute reduction in circulating insulin affects LH secretion in women with polycystic ovary syndrome (PCOS).


METHODS
Prospective study in normal and PCOS women.


METHODS
General Clinical Research Centers at the University of Virginia, the Medical College of Virginia, and the Massachusetts General Hospital.


METHODS
Six normal women and five women with PCOS.


METHODS
Administration of diazoxide to lower circulating insulin concentrations.


METHODS
Characteristics of LH secretion as appraised by multiparameter deconvolution and estimation of approximate entropy.


RESULTS
Short-term administration of diazoxide had no effect on the secretion of LH in women with PCOS.


CONCLUSIONS
Hyperinsulinemia resulting from insulin resistance in women with PCOS may not have a direct effect on gonadotropin secretion.
Evans
William S
WS
Department of Medicine, National Science Foundation Center for Biological Timing, University of Virginia, Charlottesville, 22908, USA. wse2p@virginia.edu
Taylor
Ann E
AE
Boyd
David G
DG
Johnson
Michael L
ML
Matt
Dennis W
DW
Jimenez
Yarisie
Y
Nestler
John E
JE
D000328:Adult; D015331:Cohort Studies; D003981:Diazoxide / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood / Q000378:metabolism; D000078790:Insulin Secretion; D007986:Luteinizing Hormone / Q000097:blood / Q000378:metabolism*; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000188:drug therapy* / Q000378:metabolism*; D011446:Prospective Studies; D013997:Time Factors
D007328:Insulin; D007986:Luteinizing Hormone; D003981:Diazoxide