title: Human T lymphotropic virus type 1 (HTLV-1) proviral load in asymptomatic carriers, HTLV-1-associated myelopathy/tropical spastic paraparesis, and other neurological abnormalities associated with HTLV-1 infection.
abstract: Recent reports have demonstrated that human T lymphotropic virus type 1 (HTLV-1) is associated with other neurological abnormalities in addition to HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). It has been well established that high HTLV-1 proviral loads are associated with the development of HAM/TSP. We now demonstrate, for the first time, to our knowledge, that HTLV-1 proviral loads in patients with other neurological abnormalities are also significantly higher than in asymptomatic HTLV-1 carriers.
authors.affiliation: Reference Center for Neuroinfection Diseases and HTLV, Instituto de Pesquisa Clínica Evandro Chagas, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.
authors.forename: Marcus Tulius T
authors.initials: MT
authors.lastname: Silva
authors.forename: Ramza Cabral
authors.initials: RC
authors.lastname: Harab
authors.forename: Ana Cláudia
authors.initials: AC
authors.lastname: Leite
authors.forename: Doris
authors.initials: D
authors.lastname: Schor
authors.forename: Abelardo
authors.initials: A
authors.lastname: Araújo
authors.forename: Maria José
authors.initials: MJ
authors.lastname: Andrada-Serpa
mesh_terms: D001938:Brazil; D002353:Carrier State; D020805:Central Nervous System Viral Diseases / Q000821:virology*; D005260:Female; D015368:Human T-lymphotropic virus 1 / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015493:Paraparesis, Tropical Spastic / Q000821:virology*; D010523:Peripheral Nervous System Diseases / Q000821:virology*; D011533:Proviruses / Q000302:isolation & purification*; D001750:Urinary Bladder, Neurogenic / Q000821:virology; D019562:Viral Load