The matrix corroded: podosomes and invadopodia in extracellular matrix degradation.
Podosomes and invadopodia are unique actin-rich adhesions that establish close contact to the substratum but can also degrade components of the extracellular matrix. Accordingly, matrix degradation localized at podosomes or invadopodia is thought to contribute to cellular invasiveness in physiological and pathological situations. Cell types that form podosomes include monocytic, endothelial and smooth muscle cells, whereas invadopodia have been mostly observed in carcinoma cells. This review highlights important new developments in the field, discusses the common and divergent features of podosomes and invadopodia and summarizes current knowledge about matrix-degrading proteinases at these structures.
Linder
Stefan
S
Institut für Prophylaxe und Epidemiologie der Kreislaufkrankheiten, Ludwig-Maximilians-Universität, Pettenkoferstr. 9, 80336 München, Germany. stefan.linder@med.uni-muenchen.de <stefan.linder@med.uni-muenchen.de>
D000818:Animals; D002448:Cell Adhesion; D022081:Cell Surface Extensions / Q000201:enzymology / Q000378:metabolism*; D003599:Cytoskeleton / Q000378:metabolism; D005109:Extracellular Matrix / Q000201:enzymology / Q000378:metabolism*; D006801:Humans; D010447:Peptide Hydrolases / Q000378:metabolism; D015398:Signal Transduction
D010447:Peptide Hydrolases