Identification of prion inhibitors by a fluorescence-polarization-based competitive binding assay.
Kocisko
David A
DA
Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA.
Bertholet
Nadine
N
Moore
Roger A
RA
Caughey
Byron
B
Vaillant
Andrew
A
D000818:Animals; D001665:Binding Sites; D001667:Binding, Competitive; D001681:Biological Assay; D002460:Cell Line; D006224:Cricetinae; D019793:Fluorescein / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D005454:Fluorescence Polarization; D007700:Kinetics; D051379:Mice; D011328:Prions / Q000037:antagonists & inhibitors* / Q000378:metabolism; D011994:Recombinant Proteins / Q000378:metabolism; D012608:Scrapie / Q000188:drug therapy* / Q000378:metabolism
D011328:Prions; D011994:Recombinant Proteins; D019793:Fluorescein