title: Different clinical phenotype in triplets with haemophilia A.
abstract: Although many patients with haemophilia may have exactly the same residual clotting factor level, the clinical disease phenotype may vary greatly. This variation may be related to different genetic mutations responsible for haemophilia, environmental influences and co-inheritance of polymorphisms affecting the coagulation system. The study of siblings with haemophilia offers the opportunity to examine additional factors, other than genetic mutation and environment that may impact on the clinical phenotype of haemophilia. We present the unusual case of haemophilia occurring in fraternal triplets. Each of the triplets had a slightly different pattern of bleeding and response to treatment.
authors.affiliation: Division of Haematology/Oncology, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Canada.
authors.forename: C
authors.initials: C
authors.lastname: Barnes
authors.forename: V
authors.initials: V
authors.lastname: Blanchette
authors.forename: D
authors.initials: D
authors.lastname: Lillicrap
authors.forename: K
authors.initials: K
authors.lastname: Mann
authors.forename: A M
authors.initials: AM
authors.lastname: Stain
authors.forename: J
authors.initials: J
authors.lastname: Leggo
authors.forename: P
authors.initials: P
authors.lastname: Hilliard
authors.forename: M
authors.initials: M
authors.lastname: Carcao
mesh_terms: D002675:Child, Preschool; D003198:Computer Simulation; D005169:Factor VIII / Q000235:genetics* / Q000493:pharmacokinetics; D006467:Hemophilia A / Q000235:genetics*; D006801:Humans; D007223:Infant; D008297:Male; D010641:Phenotype; D011110:Polymorphism, Genetic / Q000235:genetics*; D014310:Triplets / Q000235:genetics*
chemical_list: D005169:Factor VIII