title: Enantioselective synthesis of P-stereogenic benzophospholanes via palladium-catalyzed intramolecular cyclization.
abstract: Enantioselective or diastereoselective intramolecular cyclization of functionalized secondary phosphines or their borane adducts catalyzed by chiral Pd(diphosphine) complexes gave P-stereogenic benzophospholanes in up to 70% ee. These results provide a new method for the synthesis of chiral phospholanes, which are valuable ligands in asymmetric catalysis. [reaction: see text]
authors.affiliation: 6128 Burke Laboratory, Department of Chemistry, Dartmouth College, Hanover, NH 03755, USA.
authors.forename: Tim J
authors.initials: TJ
authors.lastname: Brunker
authors.forename: Brian J
authors.initials: BJ
authors.lastname: Anderson
authors.forename: Natalia F
authors.initials: NF
authors.lastname: Blank
authors.forename: David S
authors.initials: DS
authors.lastname: Glueck
authors.forename: Arnold L
authors.initials: AL
authors.lastname: Rheingold