title: [Serum concentration of tissue inhibitor of matrix metalloproteinases-1 (TIMP-1) correlates with markers of the disease activity in early rheumatoid arthritis].
abstract: The aim of the study was to analyse the correlations between serum concentrations of the tissue inhibitors of metalloproteinases (TIMP-1, TIMP-2) and clinical markers of the disease activity in patients with early rheumatoid arthritis. The study group consisted of 30 RA patients, untreated with disease modifying anti-rheumatic drugs or corticosteroids, with disease duration less than 3 years. The analysis of serum concentrations of TIMPs was based on a quantitative sandwich ELISA. We found the positive correlations between serum TIMP-1 level and clinical markers of the disease activity such as the Ritchie articular index, erythrocyte sedimentation rate (ESR) and disease activity score (DAS) (in all cases p<0.05). Furthermore, we observed positive correlations between serum TIMP-2 concentration and ESR (p<0.01). We conclude that studied tissue inhibitors of matrix metalloproteinases might be useful clinical markers of the disease activity in early rheumatoid arthritis.
authors.affiliation: Klinika Reumatologii i Chorób Wewnetrznych Akademii Medycznej w Białymstoku.
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Fiedorczyk
authors.forename: Piotr Adrian
authors.initials: PA
authors.lastname: Klimiuk
authors.forename: Stanisław
authors.initials: S
authors.lastname: Sierakowski
authors.forename: Ewa
authors.initials: E
authors.lastname: Gińdzieńska-Sieśkiewicz
authors.forename: Justyna
authors.initials: J
authors.lastname: Chwiećko
mesh_terms: D000328:Adult; D000368:Aged; D018501:Antirheumatic Agents / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000097:blood* / Q000175:diagnosis / Q000188:drug therapy; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D042241:Early Diagnosis; D005260:Female; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000627:therapeutic use; D008875:Middle Aged; D012217:Rheumatoid Factor / Q000097:blood*; D019715:Tissue Inhibitor of Metalloproteinase-1 / Q000097:blood* / Q000187:drug effects; D019716:Tissue Inhibitor of Metalloproteinase-2 / Q000097:blood* / Q000187:drug effects
chemical_list: D018501:Antirheumatic Agents; D015415:Biomarkers; D019715:Tissue Inhibitor of Metalloproteinase-1; D019716:Tissue Inhibitor of Metalloproteinase-2; D002097:C-Reactive Protein; D012217:Rheumatoid Factor; D008727:Methotrexate