title: Imaging of iris lesions with high-speed optical coherence tomography.
abstract: To image and measure iris tumors with optical coherence tomography (OCT).
  
  
  
  High-speed (2,000-4,000 axial-scan/sec and 4-16 frames/sec) 1.3-micron wavelength anterior segment OCT prototypes were used to image 6 eyes of 6 patients with a variety of iris lesions, including focal iris nevus, diffuse iris nevus, amelanotic iris nevus, iris melanocytosis, and iris melanoma. OCT images were compared with slit-lamp photography and ultrasound biomicroscopy.
  
  
  
  OCT at 1.3-micron wavelength could penetrate the full thickness of the iris lesions and allow three-dimensional measurement of lesion size. Internal reflectivity is correlated with pigmentation. OCT is a convenient non-contact method that provides imaging of the clinically important angle structures (scleral spur and angle recess).
  
  
  
  OCT is a new imaging modality that complements slit-lamp photography and ultrasound biomicroscopy for serial evaluation of iris
authors.affiliation: From the Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA.
authors.forename: Sophie J
authors.initials: SJ
authors.lastname: Bakri
authors.forename: Arun D
authors.initials: AD
authors.lastname: Singh
authors.forename: Careen Y
authors.initials: CY
authors.lastname: Lowder
authors.forename: Maria Regina
authors.initials: MR
authors.lastname: Chalita
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.forename: Joseph A
authors.initials: JA
authors.lastname: Izatt
authors.forename: Andrew M
authors.initials: AM
authors.lastname: Rollins
authors.forename: David
authors.initials: D
authors.lastname: Huang
mesh_terms: D000328:Adult; D000368:Aged; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007498:Iris / Q000000981:diagnostic imaging / Q000473:pathology*; D015811:Iris Neoplasms / Q000175:diagnosis*; D008297:Male; D008545:Melanoma / Q000175:diagnosis*; D033401:Microscopy, Acoustic; D008875:Middle Aged; D009506:Nevus / Q000175:diagnosis*; D041623:Tomography, Optical Coherence / Q000379:methods*