title: [Study of the interaction of main potato glycoalkaloids in inhibition of immobilized butyryl cholinesterase].
abstract: The interaction of main potato glycoalkaloids alpha-solanine and alpha-chaconine in inhibition of horse serum butyryl cholinesterases immobilized on the pH-sensitive field-effect transistors has been investigated. The method of isobol diagram of Loewe and Muishnek has been used for interpretation of results. It has been shown the alpha-chaconine inhibits the immobilized bytyryl cholinesterases more strongly than alpha-solanine, and their mixture has the addition effect.
authors.forename: V M
authors.initials: VM
authors.lastname: Arkhypova
authors.forename: S V
authors.initials: SV
authors.lastname: Dziadevych
authors.forename: N
authors.initials: N
authors.lastname: Jaffrezic-Renault
authors.forename: C
authors.initials: C
authors.lastname: Martelet
authors.forename: O P
authors.initials: OP
authors.lastname: Soldatkin
mesh_terms: D000818:Animals; D015374:Biosensing Techniques / Q000295:instrumentation / Q000379:methods*; D002091:Butyrylcholinesterase / Q000737:chemistry*; D002800:Cholinesterase Inhibitors / Q000032:analysis* / Q000302:isolation & purification / Q000494:pharmacology; D004357:Drug Synergism; D004800:Enzymes, Immobilized / Q000737:chemistry*; D006736:Horses; D006863:Hydrogen-Ion Concentration; D012992:Solanine / Q000031:analogs & derivatives* / Q000032:analysis* / Q000302:isolation & purification / Q000494:pharmacology; D011198:Solanum tuberosum / Q000737:chemistry*; D014173:Transistors, Electronic
chemical_list: D002800:Cholinesterase Inhibitors; D004800:Enzymes, Immobilized; D012992:Solanine; C011860:alpha-chaconine; D002091:Butyrylcholinesterase