title: The outcome of preterm neonates with intraventricular hemorrhage delivered with intravenous meperidine or epidural analgesia.
abstract: We aimed to study, retrospectively, the neonatal outcome of 45 preterm neonates with intraventricular hemorrhage (IVH) who were delivered vaginally with intravenous meperidine (n = 23) or epidural analgesia (n = 22). Neonates in the epidural group had a better outcome in terms of a first-minute Apgar score of 7 or less, in 31% vs 69% (P = 0.001); 5-min Apgar score of 7 or less, in 18% vs 82% (P = 0.003); a lower incidence of respiratory distress syndrome (RDS; 23% vs 30%; P = 0.03); a lower dopamine requirement during the first neonatal week (13% vs 72%; P = 0.01); and a higher survival rate (91% vs 58%, respectively; P = 0.008). It is concluded that preterm neonates with IVH had a better outcome when delivered to mothers receiving epidural analgesia as compared to those receiving intravenous meperidine.
authors.affiliation: Obstetric Anesthesia Unit, Department of Anesthesia, Edith Wolfson Medical Center, Holon, Israel.
authors.forename: Shmuel
authors.initials: S
authors.lastname: Evron
authors.forename: Tiberiu
authors.initials: T
authors.lastname: Ezri
authors.forename: Nugzar
authors.initials: N
authors.lastname: Rigini
authors.forename: Andre
authors.initials: A
authors.lastname: Gomel
authors.forename: Peter
authors.initials: P
authors.lastname: Szmuk
authors.forename: Oscar
authors.initials: O
authors.lastname: Sadan
authors.forename: David
authors.initials: D
authors.lastname: Kohelet
mesh_terms: D000328:Adult; D015360:Analgesia, Epidural / Q000009:adverse effects* / Q000379:methods; D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000009:adverse effects; D000771:Anesthesia, Intravenous / Q000009:adverse effects* / Q000379:methods; D000773:Anesthesia, Obstetrical / Q000009:adverse effects* / Q000379:methods; D000779:Anesthetics, Local / Q000008:administration & dosage / Q000009:adverse effects; D001034:Apgar Score; D002045:Bupivacaine / Q000008:administration & dosage / Q000009:adverse effects; D002543:Cerebral Hemorrhage / Q000453:epidemiology*; D002552:Cerebral Ventricles; D015897:Comorbidity; D004298:Dopamine / Q000008:administration & dosage; D015259:Dopamine Agents / Q000008:administration & dosage; D005260:Female; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D007234:Infant, Premature; D008614:Meperidine / Q000008:administration & dosage / Q000009:adverse effects*; D009035:Mothers; D011247:Pregnancy; D012127:Respiratory Distress Syndrome, Newborn / Q000453:epidemiology; D012189:Retrospective Studies; D012307:Risk Factors; D015996:Survival Rate
chemical_list: D000701:Analgesics, Opioid; D000779:Anesthetics, Local; D015259:Dopamine Agents; D008614:Meperidine; D004298:Dopamine; D002045:Bupivacaine