[A case-control study on the association between the genetic polymorphism of sulfotransferase 1A1, diet and susceptibility of colorectal cancer].
OBJECTIVE
To investigate the relationship between sulfotransferase 1Al polymorphism, diet and colorectal cancer susceptibility.


METHODS
A case-control study of 140 cancers and 343 health controls was conducted to investigate the role of sulfotransferase 1A1 polymorphism and meat consumption in colorectal carcinogenesis. Genotypes of sulfotransferase 1A1 polymorphism were analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).


RESULTS
There was no significant difference in allele frequency of SULT1A1 between the control and cancer patient populations. After adjustment for age, sex, smoking and history of diseases, red meat and well-done meat intake showed no significant association with colorectal cancer. Consumption of red meat more than 5 kg per year combined with SULT1Al slow sulfation (Arg/His and His/His) had a statistically significant association with the risk of rectal cancer ( OR = 3.78; 95% CI: 1.08 - 13. 20) compared to that consumed red meat less than 5 kg per year with fast sulfation (Arg/Arg).


CONCLUSIONS
This study suggests that SULT1A1 slow sulfation combined with higher intake of red meat may be associated with an elevated risk of rectal cancer.
Chen
Kun
K
Department of Epidemiology, Zhejiang University School of Medicine, Hangzhou 310031, China. CK@zju.edu.cn
Fan
Chun-hong
CH
Jin
Ming-juan
MJ
Song
Liang
L
Xu
Hong
H
He
Han-qing
HQ
Tong
Feng
F
D000368:Aged; D000483:Alleles; D000818:Animals; D015239:Arylsulfotransferase / Q000235:genetics*; D016022:Case-Control Studies; D002417:Cattle; D003110:Colonic Neoplasms / Q000201:enzymology / Q000209:etiology / Q000235:genetics*; D004032:Diet; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008460:Meat / Q000009:adverse effects; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012004:Rectal Neoplasms / Q000201:enzymology / Q000209:etiology / Q000235:genetics*; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects; D013552:Swine
D015239:Arylsulfotransferase; C117544:SULT1A1 protein, human