4-Methyl-1,2,3-selenadiazole-5-carboxylic acid amides: antitumor action and cytotoxic effect correlation.
Synthesis and cytotoxic activity of a series of 4-methyl-1,2,3-selenadiazole-5-carboxylic acid amides on human fibrosarcoma HT-1080, mouse hepatoma MG-22A, and mouse fibroblasts 3T3 cell lines are described. The correlation between compound LD(50) and 3T3 fibroblast cell line morphology was shown. In vivo evaluation of amides on mouse sarcoma S-180 confirms high antitumor activity (58-85%).
Arsenyan
Pavel
P
Department of Medicinal Chemistry, Latvian Institute of Organic Synthesis, Aizkraukles 21, Riga, Latvia. pavel.arsenyan@lycos.com
Rubina
Kira
K
Shestakova
Irina
I
Domracheva
Ilona
I
D016475:3T3 Cells; D000577:Amides / Q000494:pharmacology*; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002264:Carboxylic Acids / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007928:Lethal Dose 50; D051379:Mice
D000577:Amides; D000970:Antineoplastic Agents; D002264:Carboxylic Acids