Sublimation of antimycotic agents as proved by various analytical methods.
Qualitative and quantitative results demonstrate that the pure substances amorolfine base, amorolfine hydrochloride, two selected morpholine derivatives and terbinafine hydrochloride are clearly able to sublimate. As amorolfine hydrochloride is also capable to sublimate from galencial forms laquer and cream in this experimental setup, a clinical relevance of sublimation phenomenon at least for topical treatment of onychomycosis has to be considered. This phenomenon could be one reason for advantageous clinical and mycological cure rates of amorolfine nail laquer to comparable topical products reported in the literature.
Jäckel
A
A
Medical Department, Galderma Laboratorium GmbH, Düsseldorf, Germany.
Schmelzer
C E H
CE
Wartewig
S
S
Neubert
R H H
RH
D000891:Anti-Infective Agents, Local / Q000032:analysis / Q000737:chemistry*; D000935:Antifungal Agents / Q000032:analysis / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D005079:Excipients; D013058:Mass Spectrometry; D009025:Morpholines / Q000032:analysis / Q000737:chemistry*; D009281:Naphthalenes / Q000032:analysis / Q000737:chemistry; D021241:Spectrometry, Mass, Electrospray Ionization; D017550:Spectroscopy, Fourier Transform Infrared; D000077291:Terbinafine
D000891:Anti-Infective Agents, Local; D000935:Antifungal Agents; D005079:Excipients; D009025:Morpholines; D009281:Naphthalenes; C038974:amorolfine; D000077291:Terbinafine