title: Promotion of hexadecyltrimethyleamine bromide to the damage of Alexandrium sp. LC3 by cupric glutamate.
abstract: The effect of hexadecyltrimethyleamine bromide (HDTMAB) on the removal of Alexandrium sp. LC3 under cupric glutamate stress was investigated. Toxic effect of cupric glutamate on A lexandrium sp. LC3 was significantly promoted in the presence of HDTMAB, especially at 3.0 cmc of HDTMAB. It was found that the sulfhydryl group content of the cell decreased, while the malonaldehyde content and membrane permeability increased when Alexandrium sp. LC3 was treated with HDTMAB and cupric glutamate complex, compared with cupric glutamate alone. The data suggest that HDTMAB might stimulate the damage of Alexandrium sp. LC3 by enhancing the membrane permeability.
authors.affiliation: Key Laboratory of Marine Biological Active Substances, SOA, Qingdao 266061, China. lihaoh@163.com
authors.forename: Hao
authors.initials: H
authors.lastname: Li
authors.forename: Jin-lai
authors.initials: JL
authors.lastname: Miao
authors.forename: Feng-xia
authors.initials: FX
authors.lastname: Cui
authors.forename: Guang-you
authors.initials: GY
authors.lastname: Li
mesh_terms: D000818:Animals; D002463:Cell Membrane Permeability / Q000187:drug effects; D003300:Copper / Q000633:toxicity*; D004141:Dinoflagellida / Q000187:drug effects* / Q000378:metabolism*; D005971:Glutamates / Q000633:toxicity*; D015227:Lipid Peroxidation / Q000187:drug effects; D013438:Sulfhydryl Compounds / Q000378:metabolism; D013501:Surface-Active Agents / Q000633:toxicity*
chemical_list: D005971:Glutamates; D013438:Sulfhydryl Compounds; D013501:Surface-Active Agents; D003300:Copper