Cancer immunosurveillance, immunoediting and inflammation: independent or interdependent processes?
When immune cells and developing tumor cells localize to a common microenvironment, an assemblage of interactions takes place; this results in either tumor destruction by way of immunosurveillance or tumor outgrowth. These events put a functional imprint onto the emerging tumor repertoire because tumor cells arising in the presence of a fully functional immune system are less immunogenic than those that develop in the absence of immunity (i.e. in RAG2(-/-) and perforin(-/-) mice). However, other studies suggest that the immune system can also actively promote formation of certain tumors. These apparent disparate effects of immunity on tumorigenesis provide a unique model for study of the decision-making process that dictates immune function within a tumor.
Bui
Jack D
JD
Department of Pathology, University of California at San Diego, 9500 Gilman Drive MC 0612, La Jolla, CA 92093-0612, USA.
Schreiber
Robert D
RD
D000818:Animals; D004268:DNA-Binding Proteins / Q000235:genetics; D004195:Disease Models, Animal; D007109:Immunity / Q000235:genetics; D007157:Immunologic Surveillance; D007249:Inflammation / Q000276:immunology*; D007372:Interferons / Q000378:metabolism; D053759:Interleukin-23 / Q000378:metabolism; D008562:Membrane Glycoproteins / Q000235:genetics; D051379:Mice; D009369:Neoplasms / Q000276:immunology*; D054353:Perforin; D052899:Pore Forming Cytotoxic Proteins / Q000235:genetics; D011971:Receptors, Immunologic / Q000378:metabolism; D055607:Receptors, Natural Killer Cell
D004268:DNA-Binding Proteins; D053759:Interleukin-23; D008562:Membrane Glycoproteins; D052899:Pore Forming Cytotoxic Proteins; C499308:Rag2 protein, mouse; D011971:Receptors, Immunologic; D055607:Receptors, Natural Killer Cell; D054353:Perforin; D007372:Interferons