Survival after disseminated invasive aspergillosis in a multivisceral transplant recipient.
Disseminated invasive aspergillosis is a serious and potentially lethal infectious complication of immunosuppressed individuals, including transplant recipients. We report here a successfully treated case of disseminated Aspergillus fumigatus infection involving the lungs, brain, and endocardium in a multivisceral transplant recipient. In addition to supportive measures, the patient was aggressively treated with a combination of three antifungal agents, and all immunosuppression was significantly lowered with close observation for rejection. After 3 months of therapy, the patient cleared the fungal infection, made a full recovery of his cerebral function, and was discharged to a rehabilitation facility.
Vianna
R
R
Department of Surgery, Indiana University, Indianapolis, IN 46202, USA. rvianna@iupui.edu
Misra
V
V
Fridell
J A
JA
Goldman
M
M
Mangus
R S
RS
Tector
J
J
D000328:Adult; D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D001228:Aspergillosis / Q000000981:diagnostic imaging*; D017548:Echocardiography, Transesophageal; D006509:Hepatitis B / Q000601:surgery*; D006801:Humans; D007421:Intestine, Small / Q000637:transplantation*; D016031:Liver Transplantation; D008279:Magnetic Resonance Imaging; D008297:Male; D016035:Pancreas Transplantation; D011183:Postoperative Complications / Q000188:drug therapy / Q000382:microbiology; D013270:Stomach / Q000637:transplantation*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
D000935:Antifungal Agents; D000666:Amphotericin B