Motor evoked potentials after transcranial magnetic stimulation support hypothesis of coexisting central mechanism in obstetric brachial palsy.
Six infants with obstetric brachial palsy, ranging from 4 to 7 months of age, were investigated. One was suspected of having extensive brachial plexus lesions and five were suspected of having a unilateral lesion of both roots C5 and C6. All were referred to our center to investigate the possibility for reconstructive surgery. In all infants, even at this age, transcranial magnetic stimulation resulted in motor evoked potentials (MEP) in the biceps (in one, in the brachioradial) muscles. Averaging could not be done because of the intraindividual variation in latency. The MEP was easier to recognize if evoked when the infant had the arm bent. In all five infants suspected of upper brachial plexus lesion with avulsion of both roots C5 and C6 and/or complete rupture of the upper trunk, proven in four, an MEP on the lesioned side could be evoked. Combined with earlier investigations showing (almost) normal EMG and somatosensory evoked potentials in infants with upper plexus lesion, this leads us to the conclusion that the paralysis of these infants cannot only be attributed to the peripheral axonal damage alone but that central plasticity must also play an important role. As this is a slow process, some infants might not yet be able to use the paralytic muscles. Some theoretic issues are discussed.
Colon
A J
AJ
Department of Neurophysiology, Kempenhaeghe, Heeze, The Netherlands. dutchcolon@netscape.net
Vredeveld
J W
JW
Blaauw
G
G
D001917:Brachial Plexus / Q000503:physiopathology*; D020516:Brachial Plexus Neuropathies / Q000175:diagnosis* / Q000503:physiopathology*; D001931:Brain Mapping / Q000379:methods; D046690:Deep Brain Stimulation; D019054:Evoked Potentials, Motor; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D010246:Paralysis, Obstetric / Q000175:diagnosis* / Q000503:physiopathology*; D011712:Pyramidal Tracts / Q000503:physiopathology*; D050781:Transcranial Magnetic Stimulation / Q000379:methods