title: Hyperhomocysteinemia is associated with visceral adiposity in Japanese patients with type 2 diabetes mellitus.
abstract: This study aims to investigate the relationship between the circulating level of homocysteine and body adiposity in Japanese patients with type 2 diabetes mellitus. We measured the body mass index (BMI), waist and hip circumferences, visceral and subcutaneous adiposities, visceral/subcutaneous (V/S) adiposity ratio, and insulin resistance as assessed by the Homeostasis Model Assessment (HOMA) index in patients with hyperhomocysteinemia. The study group consisted of 17 Japanese patients with type 2 diabetes and hyperhomocysteinemia (age: 62+/-10 years, mean+/-S.D.), and the control group consisted of 24 age-matched type 2 diabetes patients with normohomocysteinemia (60+/-11 years). The visceral adiposity, HOMA index, and V/S ratio were significantly higher in the hyperhomocysteinemia group than in the normohomocysteinemia group (P<0.05). In contrast, the BMI, hip circumference, and subcutaneous adiposity were similar between the two groups (P>0.1). Furthermore, multiple regression analysis showed that hyperhomocysteinemia was closely related to insulin resistance and visceral adiposity. Our results indicate that the presence of hyperhomocysteinemia in our population of Japanese patients with type 2 diabetes-associated insulin resistance was associated with increased visceral but not subcutaneous adiposity.
authors.affiliation: Department of Internal Medicine 1, Faculty of Medicine, Oita University, Hasama, Oita 879-5593, Japan. Masaki@med.oita-u.ac.jp
authors.forename: Takayuki
authors.initials: T
authors.lastname: Masaki
authors.forename: Futoshi
authors.initials: F
authors.lastname: Anan
authors.forename: Manabu
authors.initials: M
authors.lastname: Anai
authors.forename: Keiko
authors.initials: K
authors.lastname: Higuchi
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Tsubone
authors.forename: Koro
authors.initials: K
authors.lastname: Gotoh
authors.forename: Seiichi
authors.initials: S
authors.lastname: Chiba
authors.forename: Isao
authors.initials: I
authors.lastname: Katsuragi
authors.forename: Katsuhiro
authors.initials: K
authors.lastname: Tanaka
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Kakuma
authors.forename: Hironobu
authors.initials: H
authors.lastname: Yoshimatsu
mesh_terms: D000273:Adipose Tissue / Q000033:anatomy & histology*; D000368:Aged; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000188:drug therapy; D004452:Echocardiography; D004562:Electrocardiography; D005260:Female; D006710:Homocysteine / Q000097:blood; D006801:Humans; D020138:Hyperhomocysteinemia / Q000453:epidemiology*; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D007564:Japan; D008297:Male; D008875:Middle Aged; D014781:Viscera
chemical_list: D007004:Hypoglycemic Agents; D006710:Homocysteine