Isolation, structure determination, and anti-cancer activity of apoptolidin D.
The isolation, characterization, and preliminary biological activity of apoptolidin D, a new apoptolidin that exhibits anti-proliferative activity against H292 human lung carcinoma cells at nanomolar concentrations, are reported. Its equilibration with isoapoptolidin D and characterization of the latter are also described. [structure: see text].
Wender
Paul A
PA
Department of Chemistry, Stanford University, Stanford, California 94305-5080, USA. wenderp@stanford.edu
Longcore
Kate E
KE
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D005285:Fermentation; D006801:Humans; D007700:Kinetics; D018942:Macrolides / Q000138:chemical synthesis* / Q000302:isolation & purification / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D009615:Nocardia / Q000378:metabolism
D000970:Antineoplastic Agents; D018942:Macrolides; C114125:apoptolidin