title: Lipoprotein (a) and apolipoprotein (a) in primary antiphospholipid syndrome.
abstract: OBJECTIVE
  To investigate whether lipoprotein (a) (Lp(a)) and/or apolipoprotein (a) (apo(a)) may be markers for clinical features of 37 patients with primary antiphospholipid syndrome (PAPS) and to compare with 37 age- and sex-matched controls.
  
  
  METHODS
  Apo(a) and Lp(a) concentrations were determined by ELISA and immunonephelometry, respectively.
  
  
  RESULTS
  Only elevated apo(a) concentrations were significant predictor for cerebrovascular insults (OR=14.399, p=0.005, 95% CI: 2.224-93.230).
  
  
  CONCLUSIONS
  Considering the fact that PAPS patients with cerebrovascular insults had recurrence of cerebrovascular episodes, measurement of apo(a) concentrations will help in the follow-up of those patients and thus in the prediction of future episodes. This finding should be further investigated in a larger study in order to provide adequate therapeutic intervention.
authors.affiliation: Institute for Medical Biochemistry, Clinical Center of Serbia, Visegradska 26, 11000 Belgrade, Serbia. bmyrjana@yahoo.co.uk
authors.forename: Mirjana
authors.initials: M
authors.lastname: Bećarević
authors.forename: Sandra
authors.initials: S
authors.lastname: Singh
authors.forename: Nada
authors.initials: N
authors.lastname: Majkić-Singh
mesh_terms: D000328:Adult; D016736:Antiphospholipid Syndrome / Q000097:blood*; D001054:Apolipoproteins A / Q000097:blood*; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D017270:Lipoprotein(a) / Q000097:blood*; D008297:Male; D008875:Middle Aged
chemical_list: D001054:Apolipoproteins A; D017270:Lipoprotein(a)