A new example of a steroid-amino acid hybrid: construction of constrained nine membered D-ring steroids.
A new archetype of steroid-amino acid hybrids containing a nine membered D-ring with hetero atoms has been synthesized for the first time from estrone and amino acids by using Yamaguchi coupling reactions.
Panda
Shagufta
S
Medicinal and Process Chemistry Division, Central Drug Research Institute, Chattar Manzil Palace, India.
Panda
Gautam
G
D000596:Amino Acids / Q000138:chemical synthesis / Q000737:chemistry*; D000598:Amino Acids, Cyclic / Q000737:chemistry; D002855:Chromatography, Thin Layer; D004970:Estrone / Q000737:chemistry; D007783:Lactones / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008956:Models, Chemical; D008968:Molecular Conformation; D015394:Molecular Structure; D010455:Peptides / Q000737:chemistry; D013237:Stereoisomerism; D013256:Steroids / Q000138:chemical synthesis / Q000737:chemistry*
D000596:Amino Acids; D000598:Amino Acids, Cyclic; D007783:Lactones; D010455:Peptides; D013256:Steroids; D004970:Estrone