Percutaneous technique for creation of tricuspid regurgitation in an ovine model.
Experimental models of tricuspid regurgitation (TR) are needed to study the percutaneous placement of prosthetic atrioventricular valves. The purpose of this study was to develop an appropriate simple and reproducible percutaneous experimental model for creation of tricuspid regurgitation. Tricuspid regurgitation was successfully created through papillary muscle avulsion using a guide-wire loop in seven sheep with regurgitation documented on right ventricular angiograms and a significant increase in heart rate and right atrial pressures. Acute onset of tricuspid regurgitation was poorly tolerated in one animal that died. Autopsy examinations showed avulsion of one papillary muscle in four animals and two papillary muscles in three animals.
Hoppe
Hanno
H
Dotter Interventional Institute, Oregon Health & Science University, Portland, OR 97239-3098, USA. hoppeh@ohsu.edu
Pavcnik
Dusan
D
Chuter
Tim A
TA
Tseng
Elaine
E
Kim
Man Deuk
MD
Bernat
Ivo
I
Uchida
Barry
B
Keller
Frederick S
FS
Rösch
Josef
J
D000792:Angiography; D000818:Animals; D001145:Arrhythmias, Cardiac / Q000209:etiology*; D002309:Cardiology / Q000379:methods*; D002404:Catheterization; D004195:Disease Models, Animal; D012756:Sheep; D014262:Tricuspid Valve Insufficiency / Q000209:etiology