title: Synthetic peptides cytomodulin-1 (CM-1) and cytomodulin-2 (CM-2) promote collagen synthesis and wound healing in vitro.
abstract: Transforming growth factor-beta1 (TGF-beta1) is believed to be a key player in wound healing, promoting cell proliferation, migration, and matrix synthesis in a variety of cell types. We have designed two peptides, i.e., cytomodulin-1 (CM-1) and cytomodulin-2 (CM-2), to simulate the binding domain of TGF-beta1. In this study we examined the bioactivity of the two synthetic peptides CM-1 and CM-2 on human foreskin fibroblasts (HFF). Synthetic peptides CM-1 and CM-2 in culture media increased wound healing of fibroblasts in an injury model in vitro. In addition, CM-1 and CM-2 enhanced the gene expression of collagen I and increased the production of pro-collagen I peptide in HFF. These results suggest that CM-1 and CM-2 have potentially useful clinical applications in wound healing.
authors.affiliation: Department of Bioengineering, California University, Berkeley, CA, USA.
authors.forename: H J
authors.initials: HJ
authors.lastname: Lam
authors.forename: S
authors.initials: S
authors.lastname: Li
authors.forename: N
authors.initials: N
authors.lastname: Lou
authors.forename: J
authors.initials: J
authors.lastname: Chu
authors.forename: R S
authors.initials: RS
authors.lastname: Bhatnagar