Photoactive barbiturate receptors: an ultimate lock-and-key system in which the key unlocks the lock.
Conditional photofragmentation is achieved with binary systems incorporating the isophthaloyl bis-aminopyridine barbiturate recognition motif and dithiane- or trithiane-based photolabile modules, which cleave only in the presence of an external sensitizer. The components of the host-guest molecular recognition pair were each outfitted with either the sensitizer or the photocleavable module. In these pairs, photoinduced fragmentation is contingent on a molecular recognition event, which brings the sensitizer into the immediate proximity of the photolabile latch. [structure: see text]
Lakkakula
Suman
S
Department of Chemistry and Biochemistry, University of Denver, Denver, CO 80208, USA.
Mitkin
Oleg D
OD
Valiulin
Roman A
RA
Kutateladze
Andrei G
AG
D000632:Aminopyrine / Q000737:chemistry / Q000494:pharmacology*; D001462:Barbital / Q000737:chemistry / Q000494:pharmacology*; D004338:Drug Combinations; D015394:Molecular Structure; D010777:Photochemistry; D010795:Phthalic Acids / Q000737:chemistry / Q000494:pharmacology*; D011807:Quinolizines / Q000737:chemistry; D011963:Receptors, GABA-A / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism*; D013457:Sulfur Compounds / Q000737:chemistry
D004338:Drug Combinations; D010795:Phthalic Acids; D011807:Quinolizines; D011963:Receptors, GABA-A; D013457:Sulfur Compounds; C030975:barbiturate receptor; C438055:dithiane; D000632:Aminopyrine; C059768:isophthalate; D001462:Barbital; C003758:aminopyrine, barbital drug combination