The effect of platelet-rich plasma on bone healing around implants placed in bone defects treated with Bio-Oss: a pilot study in the dog tibia.
OBJECTIVE
The aim of this study was to examine the influence of platelet-rich plasma (PRP) used as an adjunct to Bio-Oss for the repair of bone defects adjacent to titanium dental implants.


METHODS
In 6 mongrel dogs, 12 screw-shaped titanium dental implants were inserted into the osteotomy sites in the dogs' tibias. Before implantation, a standardized gap (2.0 mm) was created between the implant surface and the surrounding bony walls. The gaps were filled with either Bio-Oss cancellous granules alone or Bio-Oss cancellous granules mixed with PRP.


RESULTS
After 4 months, the Bio-Oss-treated defects revealed a significantly higher percentage of bone-implant contact than the defects treated with Bio-Oss and PRP (60.1% vs. 30.8%; P < .05).


CONCLUSIONS
The results indicate that when PRP is used as an adjunct to Bio-Oss in the repair of bone defects adjacent to titanium dental implants, PRP may decrease periimplant bone healing.
You
Tae-Min
TM
Department of Oral & Maxillofacial Surgery, College of Dentistry, Yonsei University, Seoul, South Korea.
Choi
Byung-Ho
BH
Li
Jingxu
J
Jung
Jae-Hyung
JH
Lee
Hyeon-Jung
HJ
Lee
Seoung-Ho
SH
Jeong
Seung-Mi
SM
D000818:Animals; D018786:Bone Substitutes / Q000627:therapeutic use*; D015921:Dental Implants; D004285:Dogs; D005260:Female; D007091:Image Processing, Computer-Assisted; D008903:Minerals / Q000627:therapeutic use*; D010865:Pilot Projects; D053657:Platelet-Rich Plasma / Q000502:physiology*; D013977:Tibia / Q000601:surgery*; D014025:Titanium; D016896:Treatment Outcome; D014945:Wound Healing / Q000502:physiology*
C077540:Bio-Oss; D018786:Bone Substitutes; D015921:Dental Implants; D008903:Minerals; D014025:Titanium