Treatment of Tacrolimus-associated thrombotic microangiopathy in renal transplant recipient with fresh frozen plasma: A case report.
PThrombotic microangiopathy (TMA) is a rare serious adverse reaction of calcineurin inhibitors, tacrolimus and cyclosporin. We report a case of a young male renal transplant recipient treated with tacrolimus, who developed TMA. Treatment included discontinuation of tacrolimus, increasing the dose of mycophenolate mofetil and infusion of fresh-frozen plasma. This was followed by normalization of renal function and dis-appearance of proteinuria. The remission has been sustained after a follow-up of nine months.
Kais
Harzallah
H
Unit of Nephrology, Military Hospital of Tunis, Tunisia.
Nourredine
Cherif
C
Raoudha
Belhadj
B
Emira
Chelbi
C
Tarek
Sraeib
S
Fehmi
Saddek
S
Ezzedine
Boussema
B
Jalel
Hmida
H
Jamel
Manaa
M
D016572:Cyclosporine / Q000627:therapeutic use; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D016030:Kidney Transplantation; D016559:Tacrolimus / Q000627:therapeutic use; D057049:Thrombotic Microangiopathies
D007166:Immunosuppressive Agents; D016572:Cyclosporine; D016559:Tacrolimus