title: Coronary artery bypass surgery versus percutaneous coronary intervention with drug-eluting stent implantation in patients with multivessel coronary disease.
abstract: BACKGROUND
  Drug-eluting stents (DES) constitute a major breakthrough in restenosis prevention after percutaneous coronary intervention (PCI). This study compared the clinical outcomes of PCI using DES versus coronary artery bypass graft (CABG) in patients with multivessel coronary artery disease (MVD) in real-world.
  
  
  METHODS
  From January 2003 to December 2004, 466 consecutive patients with MVD underwent revascularization, 235 by PCI with DES and 231 by CABG. The study end-point was the incidence of major adverse cardiovascular events (MACEs) at the first 30 days after procedure and during follow-up.
  
  
  RESULTS
  Most preoperative characteristics were similar in the two groups, but left main disease (24.7% vs 2.6%, P<0.001) and three-vessel disease (65% vs 54%, P = 0.02) were more prevalent in CABG group. The number of coronary lesions was also greater in CABG group (3.7 +/- 1.1 vs 3.3 +/- 1.1, P<0.001). Despite higher early morbidity (3.9% vs 0.8%, P = 0.03) associated with CABG, there were no significant differences in composite MACEs at the first 30 days between the two groups. During follow-up (mean 25+/-8 months), the incidence of death, myocardial infarction, or cerebrovascular event was similar in both groups (PCI 6.3% vs CABG 5.6%, P = 0.84). However, bypass surgery still afforded a lower need for repeat revascularization (2.8% vs 10.4%, p = 0.001). Consequently, overall MACE rate (14.5% vs 7.9%, P = 0.03) remained higher after PCI.
  
  
  CONCLUSIONS
  PCI with DES is a safe and feasible alternative to CABG for selected patients with MVD. The reintervention gap was further narrowed in the era of DES. Aside from restenosis, progression of disease needs to receive substantial emphasis.
authors.affiliation: Department of Cardiology, RuiJin Hospital Affiliated to JiaoTong University, Shanghai, China.
authors.forename: Zhen Kun
authors.initials: ZK
authors.lastname: Yang
authors.forename: Wei Feng
authors.initials: WF
authors.lastname: Shen
authors.forename: Rui Yan
authors.initials: RY
authors.lastname: Zhang
authors.forename: Ye
authors.initials: Y
authors.lastname: Kong
authors.forename: Jian Sheng
authors.initials: JS
authors.lastname: Zhang
authors.forename: Jian
authors.initials: J
authors.lastname: Hu
authors.forename: Qi
authors.initials: Q
authors.lastname: Zhang
authors.forename: Feng Hua
authors.initials: FH
authors.lastname: Ding
mesh_terms: D000368:Aged; D015906:Angioplasty, Balloon, Coronary / Q000706:statistics & numerical data*; D019917:Blood Vessel Prosthesis Implantation; D002681:China / Q000453:epidemiology; D001026:Coronary Artery Bypass / Q000706:statistics & numerical data*; D003324:Coronary Artery Disease / Q000453:epidemiology / Q000401:mortality / Q000473:pathology / Q000601:surgery / Q000628:therapy*; D023903:Coronary Restenosis; D018572:Disease-Free Survival; D016503:Drug Delivery Systems; D005260:Female; D006801:Humans; D007902:Length of Stay; D008297:Male; D017063:Outcome Assessment, Health Care; D012720:Severity of Illness Index; D015607:Stents / Q000706:statistics & numerical data; D016019:Survival Analysis