Using or abusing: viruses and the cellular DNA damage response.
During infection, viruses attempt to hijack the cell while the host responds with various defense systems. Traditional defenses include the interferon response and apoptosis, but recent work suggests that this antiviral arsenal also includes the cellular DNA damage response machinery. The observation of interactions between viruses and cellular DNA repair proteins has not only uncovered new complexities of the virus-host interaction but is also reinforcing the view that viruses can reveal key regulators of cellular pathways through the proteins they target.
Lilley
Caroline E
CE
Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
Schwartz
Rachel A
RA
Weitzman
Matthew D
MD
D000818:Animals; D004249:DNA Damage; D004260:DNA Repair; D006801:Humans; D011506:Proteins / Q000378:metabolism*; D015398:Signal Transduction; D014764:Viral Proteins / Q000378:metabolism; D014780:Viruses / Q000378:metabolism*
D011506:Proteins; D014764:Viral Proteins