Antidepressant activity of sarsasapogenin from Anemarrhena asphodeloides Bunge (Liliaceae).
The aim of this study was to investigate the effects of sarsasapogenin from Anemarrhena asphodeloides Bunge (Liliaceae) on two experimental models of depression in rats. After a two-week treatment, sarsasapogenin markedly shortened the immobility time in the forced swimming test and decreased the number of escape deficits in the learned helplessness paradigm, however, locomotor activity was not affected.
Ren
L X
LX
School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, China.
Luo
Y F
YF
Li
X
X
Wu
Y L
YL
D000818:Animals; D000928:Antidepressive Agents; D006380:Helplessness, Learned; D019668:Liliaceae / Q000737:chemistry*; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D013150:Spirostans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D013550:Swimming / Q000523:psychology
D000928:Antidepressive Agents; D013150:Spirostans; C046297:sarsasapogenin