title: Synthesis and biological activities of novel furo[2,3,4-jk][2]benzazepin-4(3H)-one derivatives.
abstract: A novel seven-membered lactam formation method has been established by intramolecular ring closure reaction of 4-bromo-(E)-3-[(2-alkylvinyl)carbonylamino]benzo[b]furans under Heck coupling conditions. A number of furo[2,3,4-jk][2]benzazepin-4(3H)-ones, tricyclicbenzo[b]furans, have been prepared by this method and evaluated for their leukotriene B(4) (LTB(4)) receptor and poly(ADP-ribose)polymerase-1 (PARP-1) inhibitory activities.
authors.affiliation: School of Pharmaceutical Sciences, Mukogawa Women's University, 11-68 Koshien Kyuban-cho, Nishinomiya 663-8179, Japan.
authors.forename: Kumiko
authors.initials: K
authors.lastname: Ando
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Akai
authors.forename: Jun-Ichi
authors.initials: J
authors.lastname: Kunitomo
authors.forename: Takehiko
authors.initials: T
authors.lastname: Yokomizo
authors.forename: Hidemitsu
authors.initials: H
authors.lastname: Nakajima
authors.forename: Tadayoshi
authors.initials: T
authors.lastname: Takeuchi
authors.forename: Masayuki
authors.initials: M
authors.lastname: Yamashita
authors.forename: Shunsaku
authors.initials: S
authors.lastname: Ohta
authors.forename: Takahiro
authors.initials: T
authors.lastname: Ohishi
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Ohishi
mesh_terms: D000818:Animals; D001552:Benzazepines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001572:Benzofurans / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D016466:CHO Cells; D006224:Cricetinae; D003412:Cricetulus; D004789:Enzyme Activation / Q000187:drug effects; D006801:Humans; D015394:Molecular Structure; D000071137:Poly (ADP-Ribose) Polymerase-1; D000067856:Poly(ADP-ribose) Polymerase Inhibitors; D018102:Receptors, Leukotriene B4 / Q000037:antagonists & inhibitors; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D001552:Benzazepines; D001572:Benzofurans; D000067856:Poly(ADP-ribose) Polymerase Inhibitors; D018102:Receptors, Leukotriene B4; C499320:PARP1 protein, human; D000071137:Poly (ADP-Ribose) Polymerase-1