Species-specific differences in the susceptibilities of biofilms formed by Candida bloodstream isolates to echinocandin antifungals.
The echinocandin susceptibilities of bloodstream Candida isolates growing in a biofilm was investigated. Within the therapeutic range of concentrations of each drug, caspofungin and micafungin were active against biofilms formed by Candida albicans or C. glabrata but not those formed by C. tropicalis or C. parapsilosis.
Choi
Hyun Woo
HW
Department of Laboratory Medicine, Chonnam National University Medical School, 8 Hakdong Dongku, Gwangju 501-757, South Korea.
Shin
Jong Hee
JH
Jung
Sook In
SI
Park
Kyung Hwa
KH
Cho
Duck
D
Kee
Seung Jung
SJ
Shin
Myung Geun
MG
Suh
Soon Pal
SP
Ryang
Dong Wook
DW
D000935:Antifungal Agents / Q000494:pharmacology*; D018441:Biofilms / Q000187:drug effects* / Q000254:growth & development; D001769:Blood / Q000382:microbiology*; D002175:Candida / Q000145:classification / Q000187:drug effects* / Q000254:growth & development / Q000302:isolation & purification; D002177:Candidiasis / Q000188:drug therapy; D054714:Echinocandins; D005656:Fungal Proteins / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D010456:Peptides, Cyclic / Q000494:pharmacology*; D013045:Species Specificity
D000935:Antifungal Agents; D054714:Echinocandins; D005656:Fungal Proteins; D010456:Peptides, Cyclic; C007572:echinocandin B