Posttransplant Hodgkin lymphoma preceded by polymorphic posttransplant lymphoproliferative disorder: report of a pediatric case and review of the literature.
Epstein-Barr virus-mediated posttransplant lymphoproliferative disorder (PTLD) is a well-recognized complication of immunosuppression in transplant patients and has broad clinical manifestations and pathologic features ranging from reactive lymphoid proliferation to malignant lymphoma. The category of Hodgkin lymphoma and Hodgkin lymphomalike PTLD is an uncommon variant of PTLD. Development of Hodgkin lymphoma subsequent to other subtypes of PTLD in the same patient is even more unusual, especially in pediatric patients. In this report, we describe a pediatric case of Epstein-Barr virus-associated posttransplant Hodgkin lymphoma developing several years after the patient was diagnosed with polymorphic PTLD and review the literature of the previously reported cases in children to further help characterize the clinical features, histopathologic appearances, biology, and treatment strategies of this uncommon entity.
Gheorghe
Gabriela
G
Department of Pathology, University of Colorado School of Medicine, The Children's Hospital, Denver, CO 80218, USA.
Albano
Edythe A
EA
Porter
Christopher C
CC
McGavran
Loris
L
Wei
Qi
Q
Meltesen
Lynne
L
Danielson
Susan M
SM
Liang
Xiayuan
X
D000234:Adenoids / Q000473:pathology; D000328:Adult; D001656:Biliary Atresia / Q000601:surgery; D002648:Child; D020031:Epstein-Barr Virus Infections / Q000150:complications / Q000276:immunology*; D006689:Hodgkin Disease / Q000150:complications / Q000276:immunology* / Q000821:virology; D006801:Humans; D016867:Immunocompromised Host; D007150:Immunohistochemistry; D007165:Immunosuppression Therapy / Q000009:adverse effects; D017404:In Situ Hybridization, Fluorescence; D007223:Infant; D016031:Liver Transplantation / Q000009:adverse effects*; D008198:Lymph Nodes / Q000473:pathology; D008232:Lymphoproliferative Disorders / Q000150:complications / Q000276:immunology* / Q000821:virology; D008297:Male; D014066:Palatine Tonsil / Q000473:pathology; D016133:Polymerase Chain Reaction; D011230:Precancerous Conditions / Q000150:complications / Q000276:immunology / Q000821:virology; D012367:RNA, Viral / Q000032:analysis; D016539:Reed-Sternberg Cells / Q000473:pathology
D012367:RNA, Viral