Sequence analysis and evolution of group B rotaviruses.
Human group B rotaviruses were isolated from hospitalized patients in Bangladesh between July 2003 and December 2004. Phylogenetic analyses of the gene segments encoding the hemagglutinin (VP4), glycoprotein (VP7) and RNA-binding protein (NSP2) of group B rotaviruses showed that Bangladeshi strains were more similar to the Indian strains than to the prototype Chinese strains. Moreover, all human strains were clustered together and were distantly related to the animal strains. With limited sequence data, the evolutionary rate of the glycoproteins (VP7) of human group B rotaviruses was estimated to be 1.57x10(-3) nucleotide substitutions/(siteyear), which was comparable to other rapidly evolving RNA viruses. The most recent common ancestor (MRCA) of the extant human group B rotaviruses was calculated to date to around 1976.
Rahman
Mustafizur
M
Laboratory of Virology, ICDDR,B, GPO Box-128, Dhaka 1000, Bangladesh. mustafizur.rahman@uz.kuleuven.ac.be
Hassan
Zahid M
ZM
Zafrul
Hasan
H
Saiada
Farjana
F
Banik
Sukalyani
S
Faruque
Abu S G
AS
Delbeke
Thomas
T
Matthijnssens
Jelle
J
Van Ranst
Marc
M
Azim
Tasnim
T
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000595:Amino Acid Sequence; D000956:Antigens, Viral / Q000737:chemistry / Q000235:genetics; D001483:Base Sequence; D036022:Capsid Proteins / Q000737:chemistry / Q000235:genetics; D002648:Child; D002675:Child, Preschool; D019143:Evolution, Molecular; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D010802:Phylogeny; D012401:Rotavirus / Q000145:classification* / Q000235:genetics
D000956:Antigens, Viral; D036022:Capsid Proteins; C050779:VP7 protein, Rotavirus