Transformation of the proteasome with age-related macular degeneration.
The proteasome mediates pathways associated with oxidative stress and inflammation, two pathogenic events correlated with age-related macular degeneration (AMD). In human donor eyes corresponding to four stages of AMD, we found the proteasomal chymotrypsin-like activity increased in neurosensory retina with disease progression. Increased activity correlated with a dramatic increase in the inducible subunits of the immunoproteasome, which was not due to an increase in CD45 positive immune cells in the retina. The novel observation of proteasome transformation may reflect retinal response to local inflammation or oxidative stress with AMD.
Ethen
Cheryl M
CM
Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.
Hussong
Stacy A
SA
Reilly
Cavan
C
Feng
Xiao
X
Olsen
Timothy W
TW
Ferrington
Deborah A
DA
D000818:Animals; D016207:Cytokines / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D007249:Inflammation / Q000201:enzymology; D017493:Leukocyte Common Antigens / Q000378:metabolism; D008268:Macular Degeneration / Q000201:enzymology* / Q000276:immunology / Q000473:pathology; D018384:Oxidative Stress; D046988:Proteasome Endopeptidase Complex / Q000737:chemistry / Q000276:immunology / Q000378:metabolism*; D021122:Protein Subunits; D051381:Rats; D011916:Rats, Inbred F344; D012160:Retina / Q000201:enzymology
D016207:Cytokines; D021122:Protein Subunits; D017493:Leukocyte Common Antigens; C516769:PTPRC protein, human; D046988:Proteasome Endopeptidase Complex