Terminal differentiation of lymphocytes depends on Blimp-1.
B lymphocyte induced maturation protein 1 (Blimp-1) has long been considered a master regulator of the terminal differentiation of B cells into antibody-secreting plasma cells. Gene-targeting experiments have now demonstrated that quantitative changes in Blimp-1 expression define plasma cell ontogeny--a process that requires the continual function of Blimp-1. Recently, new roles for Blimp-1 have been revealed, as a suppressor of diffuse large B cell lymphoma and as a key regulator of T-cell differentiation. Blimp-1 is expressed in differentiated effector T cells and controls their homeostasis. These new findings suggest that Blimp-1 has a conserved function in the final differentiation of both the cellular and the humoral arm of the adaptive immune response.
Kallies
Axel
A
The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria, Australia.
Nutt
Stephen L
SL
D000818:Animals; D002454:Cell Differentiation / Q000235:genetics; D006706:Homeostasis / Q000235:genetics / Q000276:immunology; D006801:Humans; D016393:Lymphoma, B-Cell / Q000235:genetics*; D038041:Lymphopoiesis / Q000235:genetics*; D051379:Mice; D010950:Plasma Cells / Q000276:immunology; D000074462:Positive Regulatory Domain I-Binding Factor 1; D012097:Repressor Proteins / Q000032:analysis / Q000235:genetics / Q000502:physiology*; D013601:T-Lymphocytes / Q000276:immunology*; D014157:Transcription Factors / Q000032:analysis / Q000235:genetics / Q000502:physiology*
C513258:Prdm1 protein, mouse; D012097:Repressor Proteins; D014157:Transcription Factors; D000074462:Positive Regulatory Domain I-Binding Factor 1