title: [Renal tubular epithelocytic changes in hypercysteinemia and experimental chronic renal failure].
abstract: One group of adult male Wistar rats received DL-homocysteine, 13.4 mg/kg body weight every day (an HC-group) while the rats underwent subtotal nephrectomy (a SN-group) and were killed 3 weeks later. Both light and electron microscopies were used to analyze obtained renal specimens. A total loss of the brush border in some proximal tubular (PT) cells and an increase of autophagosomes and emergence of the loci of disorganized cytoplasm were observed in the HC-group, while in the SN-group there was a significant increase in the number and size of secondary lysosomes and of foci of the cytoplasmic disorganization.
authors.forename: V G
authors.initials: VG
authors.lastname: Sipovskiĭ
authors.forename: A I
authors.initials: AI
authors.lastname: Nepovorotin
authors.forename: A V
authors.initials: AV
authors.lastname: Smirtnov
authors.forename: V A
authors.initials: VA
authors.lastname: Dobronravov
authors.forename: S E
authors.initials: SE
authors.lastname: Khokhlov
authors.forename: N N
authors.initials: NN
authors.lastname: Petrishchev
authors.forename: V V
authors.initials: VV
authors.lastname: Barabanova
authors.forename: S G
authors.initials: SG
authors.lastname: Chefu
authors.forename: E A
authors.initials: EA
authors.lastname: Borisova
mesh_terms: D000818:Animals; D001343:Autophagy; D003593:Cytoplasm / Q000648:ultrastructure*; D006710:Homocysteine / Q000633:toxicity; D007668:Kidney / Q000648:ultrastructure*; D007676:Kidney Failure, Chronic / Q000139:chemically induced / Q000473:pathology*; D008247:Lysosomes / Q000648:ultrastructure*; D008297:Male; D009392:Nephrectomy; D051381:Rats; D017208:Rats, Wistar
chemical_list: D006710:Homocysteine