title: [Study on the association between the HLA-DRB1 alleles and type 2 diabetes in Yi nationality of Yunnan].
abstract: OBJECTIVE
  To investigate the association between the polymorphism of HLA-DRB1 alleles and type 2 diabetes mellitus in Yi nationality of Yunnan.
  
  
  METHODS
  Polymerase chain reaction-sequence specific primers (PCR-SSP) genotyping method was conducted in 79 patients with type 2 diabetes mellitus and 47 ethnically matched controls in Yi Nationality Autonomous Prefecture, Chuxiong.
  
  
  RESULTS
  HLA-DR7 and DR11 allele frequencies in type 2 diabetic mellitus patients were significantly higher than those in non-diabetic control subjects respectively(P is 0.009, RR is 8.329;P is 0.029, RR is 7.734).
  
  
  CONCLUSIONS
  DR7 and DR11 alleles are probably susceptible genes of type 2 diabetes mellitus in Yunnan Yi nationality.
authors.affiliation: The Clinical Laboratory, the Second Affiliated Hospital, Kunming Medical College, Kunming, Yunnan, 650101 PR China.
authors.forename: Hong-ying
authors.initials: HY
authors.lastname: Yang
authors.forename: Li
authors.initials: L
authors.lastname: Xue
authors.forename: Mian
authors.initials: M
authors.lastname: Xu
authors.forename: Chun-feng
authors.initials: CF
authors.lastname: Ren
authors.forename: Hui-yun
authors.initials: HY
authors.lastname: Yuan
authors.forename: Wen-lin
authors.initials: WL
authors.lastname: Tai
authors.forename: Yu
authors.initials: Y
authors.lastname: Yang
authors.forename: Wei
authors.initials: W
authors.lastname: He
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D001483:Base Sequence; D002681:China; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006801:Humans; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D017422:Sequence Analysis, DNA
chemical_list: D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains