title: Cortical involvement in four cases of primary lateral sclerosis using [(11)C]-flumazenil PET.
abstract: Four PLS patients underwent cerebral [(11)C]-flumazenil PET. They were compared firstly with a group of controls, then later directly with a group of sporadic ALS patients and a familial ALS group homozygous for the 'D90A' SOD1 gene mutation. There was a similar pattern of decreased binding in PLS patients when compared to controls as that seen in a previous study of sporadic ALS patients, supporting the concept that PLS is part of the same overall spectrum of MND. However, in direct group comparisons, both sporadic and homD90A ALS patients demonstrated relative decreases in anterior and orbito-frontal binding compared to PLS patients, suggesting that there may be differences in cortical vulnerability between phenotypic groups.
authors.affiliation: Department of Neurology, The Radcliffe Infirmary, Oxford, UK. turnermr@doctors.org.uk
authors.forename: Martin R
authors.initials: MR
authors.lastname: Turner
authors.forename: Alexander
authors.initials: A
authors.lastname: Hammers
authors.forename: Ammar
authors.initials: A
authors.lastname: Al-Chalabi
authors.forename: Christopher E
authors.initials: CE
authors.lastname: Shaw
authors.forename: Peter M
authors.initials: PM
authors.lastname: Andersen
authors.forename: David J
authors.initials: DJ
authors.lastname: Brooks
authors.forename: P Nigel
authors.initials: PN
authors.lastname: Leigh
mesh_terms: D000328:Adult; D000368:Aged; D002247:Carbon Isotopes; D002540:Cerebral Cortex / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016472:Motor Neuron Disease / Q000000981:diagnostic imaging* / Q000473:pathology*; D049268:Positron-Emission Tomography / Q000379:methods*
chemical_list: D002247:Carbon Isotopes