title: Survival following complete resection of multifocal T4 node-negative NSCLC: a retrospective study.
abstract: BACKGROUND
  Multifocal NSCLC in the same lobe are staged as T4. This study was designed to assess the impact of multifocal NSCLC in the same lobe on survival in completely resected node-negative patients to determine whether the T4 (stage III B) designation is valid.
  
  
  METHODS
  We reviewed our database from October 1987 through 2004 to identify completely resected patients with N0 multifocal (T4) NSCLC. Patients with multifocal pure bronchiolo-alveolar carcinoma were excluded. Thirty-two patients had multifocal NSCLC in the same lobe and were node-negative.
  
  
  RESULTS
  Five-year survival rate was 42.4 % for the whole group with a median survival of 48 months. When tumors were staged independently of the satellite nodule/s, patients in stage I A had a 5-year survival rate of 55 % while those in stage I B had a rate of 22 %.
  
  
  CONCLUSIONS
  Patients with N0 multifocal intralobar NSCLC should be upstaged but not to stage IIIB. They should undergo complete surgical resection whenever multiple nodules are detected preoperatively.
authors.affiliation: Thoracic Surgery Unit, Verona City Hospital, Verona, Italy. alterzi@libero.it
authors.forename: A
authors.initials: A
authors.lastname: Terzi
authors.forename: G
authors.initials: G
authors.lastname: Falezza
authors.forename: C
authors.initials: C
authors.lastname: Benato
authors.forename: G
authors.initials: G
authors.lastname: Genestreti
authors.forename: A
authors.initials: A
authors.lastname: Santo
authors.forename: S
authors.initials: S
authors.lastname: Furia
authors.forename: B
authors.initials: B
authors.lastname: Feil
authors.forename: F
authors.initials: F
authors.lastname: Calabrò
mesh_terms: D000328:Adult; D000368:Aged; D002289:Carcinoma, Non-Small-Cell Lung / Q000401:mortality* / Q000473:pathology / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008175:Lung Neoplasms / Q000401:mortality* / Q000473:pathology / Q000601:surgery; D008198:Lymph Nodes / Q000473:pathology*; D008207:Lymphatic Metastasis; D008297:Male; D008481:Mediastinoscopy; D008482:Mediastinum; D008875:Middle Aged; D009367:Neoplasm Staging; D011013:Pneumonectomy / Q000379:methods*; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate / Q000639:trends