[Delta-opioid receptor activation prevents appearance of irreversible damages of cardiomyocytes and exacerbates myocardial contractility dysfunction during ischemia and reperfusion].
It is shown that prestimulation of cardiac delta-opioid receptors (OR) by selective agonists (DPDPE and TAN-67) decreases creatine kinase levels in the coronary effluent of isolated rat heart during 45-min global ischemia and 30-min reperfusion. This effect was completely abolished by pretreatment with a delta-antagonist naltrindole or a non-selective agonist naloxone. It was found that preactivation of cardiac delta-OR exacerbates reperfusion contractility dysfunction of the heart. This effect was also eliminated by opioid receptor antagonists. It is suggested that stimulation of cardiac delta-OR prevents irreversible cardiac cell damage but exacerbates contractility dysfunction during ischemia and reperfusion in vitro.
Maslov
L N
LN
Platonov
A A
AA
Lasukova
T V
TV
Lishmanov
Iu B
IuB
Oeltgen
P
P
Nagase
H
H
Podoksenov
Iu K
IuK
Podoksenov
A Iu
AIu
D000818:Animals; D003402:Creatine Kinase / Q000032:analysis; D020881:Enkephalin, D-Penicillamine (2,5)- / Q000494:pharmacology; D006321:Heart / Q000503:physiopathology; D066298:In Vitro Techniques; D008297:Male; D009200:Myocardial Contraction; D015428:Myocardial Reperfusion Injury / Q000378:metabolism / Q000473:pathology* / Q000517:prevention & control*; D032383:Myocytes, Cardiac / Q000473:pathology*; D018377:Neurotransmitter Agents / Q000494:pharmacology; D011804:Quinolines / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D017465:Receptors, Opioid, delta / Q000819:agonists*
D018377:Neurotransmitter Agents; D011804:Quinolines; D017465:Receptors, Opioid, delta; C094142:TAN 67; D020881:Enkephalin, D-Penicillamine (2,5)-; D003402:Creatine Kinase