title: Late-onset self-healing reticulohistiocytosis: pediatric case of Hashimoto-Pritzker type Langerhans cell histiocytosis.
abstract: An 8-year-old otherwise healthy girl presented with a 3-month history of multiple asymptomatic, reddish-brown papules over the face and upper limbs. Histopathological and immunohistochemical examinations demonstrated an infiltrate of mononuclear cells containing abundant histiocytic cells in the dermis, and microabscess-like accumulation of the histiocytic cells in the epidermis. The histiocytic cells were positive for antibodies against S-100 protein and CD1a, but negative for anti-CD68. Lag and anti-langerin monoclonal antibodies reacted more weakly with these histiocytic cells than with Langerhans cells in the surrounding epidermis. The skin lesions spontaneously regressed within the following 3 months, and neither systemic involvement nor local recurrence was observed during the next 10 months. This case should be categorized as congenital self-healing reticulohistiocytosis (Hashimoto-Pritzker), although the onset was not early in life.
authors.affiliation: Department of Dermatology, Osaka Red Cross Hospital, Ten'noji-ku, Osaka, Japan.
authors.forename: Kyoko
authors.initials: K
authors.lastname: Nakahigashi
authors.forename: Miyuki
authors.initials: M
authors.lastname: Ohta
authors.forename: Rie
authors.initials: R
authors.lastname: Sakai
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Sugimoto
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Ikoma
authors.forename: Yuji
authors.initials: Y
authors.lastname: Horiguchi
mesh_terms: D017668:Age of Onset; D001132:Arm / Q000473:pathology; D002648:Child; D005145:Face / Q000473:pathology; D005260:Female; D006644:Histiocytes / Q000276:immunology / Q000473:pathology; D006646:Histiocytosis, Langerhans-Cell / Q000473:pathology*; D006801:Humans; D007801:Langerhans Cells / Q000276:immunology / Q000473:pathology; D012867:Skin / Q000473:pathology*