title: Automatic 4-D Registration in Dynamic MR Renography.
abstract: Dynamic contrast-enhanced 4-D MR renography has the potential for broad clinical applications, but suffers from respiratory motion that limits analysis and interpretation. Since each examination yields at least over 10 - 20 serial 3-D images of the abdomen, manual registration is prohibitively labor-intensive. Besides in-plane motion and translation, out-of-plane motion and rotation are observed in the image series. In this paper, a novel robust and automated technique for removing out-of-plane translation and rotation with sub-voxel accuracy in 4-D dynamic MR images is presented. The method was evaluated on simulated motion data derived directly from a clinical patients data. The method was also tested on 24 clinical patient kidney data sets. Registration results were compared with a mutual information method, in which differences between manually co-registered time-intensity curves and tested time-intensity curves were compared. Evaluation results showed that our method agreed well with these ground truth data.
authors.affiliation: Department of Biomedical Engineering, Columbia University, New York, NY 10027 USA. (Phone: 212-854-5996; fax: 212-854-5995; e-mail: ts2060@Columbia.edu).
authors.forename: Ting
authors.initials: T
authors.lastname: Song
authors.forename: Vivian
authors.initials: V
authors.lastname: Lee
authors.forename: Henry
authors.initials: H
authors.lastname: Rusinek
authors.forename: Manmeen
authors.initials: M
authors.lastname: Kaur
authors.forename: Andrew
authors.initials: A
authors.lastname: Laine