title: [Schinus terebinthifolius Raddi and it's influence in the healing process of colonic anastomosis: experimental study in rats].
abstract: BACKGROUND
  The healing is a complex biological event that involves inflammation, chemotaxis, cells proliferation, differentiation and remodeling. In Brazilian popular medicine, the "Aroeira" is used to treat different situations The anastomotic healing is always a preoccupation among surgeons. The fail in intestinal anastomosis leads to fistulas and dehiscences.
  
  
  OBJECTIVE
  To evaluate the effect of the hydroalcoholic extract of Schinus terebinthifolius Raddi (Brazilian pepper tree) in the healing of colonic anastomosis.
  
  
  METHODS
  Forty Wistar rats were randomly divided in two groups (Aroeira and control), each one with 20 animals, according to the treatment received after the anastomosis (Aroeira extract or saline solution 0,9%) and each group was divided in two subgroups (C3 and C7 and A3 and A7,) according to the euthanasia day (at 3rd and at 7th). The macroscopic, microscopic and bursting pressure measurements were performed. To evaluate the groups, the non-parametric test of Mann-Whitney was applied.
  
  
  RESULTS
  In the macroscopic aspects, there was no significant difference between the Aroeira and the control group, both at the 3rd and the 7th days. When compared the subgroups of microscopic analysis at the 3rd day, the difference between the Aroeira and the control group was significant in the variables congestion (p = 0.005), polymorphonuclears (p = 0.034), mononuclears (p = 0.023), fibroblastic proliferation (p = 0.023) and at the healing stage (p = 0.001). At the 7th day analysis, the difference between the Aroeira and the control group was significant in all the variables of microscopic analysis. No significant differences were found in the bursting pressure.
  
  
  CONCLUSIONS
  It was observed a favorable effect of Aroeira, at microscopic level, in the healing process of colonic anastomosis.
authors.affiliation: Universidade Federal do Maranhao.
authors.forename: Itágores Hoffman I Lopes Sousa
authors.initials: IH
authors.lastname: Coutinho
authors.forename: Orlando Jorge Martins
authors.initials: OJ
authors.lastname: Torres
authors.forename: Jorge Eduardo F
authors.initials: JE
authors.lastname: Matias
authors.forename: Júlio Cezar U
authors.initials: JC
authors.lastname: Coelho
authors.forename: Henrique Jorge
authors.initials: HJ
authors.lastname: Stahlke Júnior
authors.forename: Miguel Angelo
authors.initials: MA
authors.lastname: Agulham
authors.forename: Enio
authors.initials: E
authors.lastname: Bachle
authors.forename: Paulo Antonio Monteiro
authors.initials: PA
authors.lastname: Camargo
authors.forename: Silvânia Klug
authors.initials: SK
authors.lastname: Pimentel
authors.forename: Alexandre Coutinho Teixeira
authors.initials: AC
authors.lastname: de Freitas
mesh_terms: D027926:Anacardiaceae / Q000737:chemistry*; D000714:Anastomosis, Surgical; D000818:Animals; D003106:Colon / Q000601:surgery* / Q000648:ultrastructure; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D007249:Inflammation / Q000188:drug therapy; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D018709:Statistics, Nonparametric; D013718:Tensile Strength / Q000187:drug effects; D013997:Time Factors; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D010936:Plant Extracts