New types of MYST3-CBP and CBP-MYST3 fusion transcripts in t(8;16)(p11;p13) acute myeloid leukemias.
The t(8;16)(p11;p13) translocation, associated with poor prognosis acute monocytic leukemia, fuses MYST3 on chromosome region 8p11 to CBP on chromosome region 16p13. Two types of MYST3-CBP and CBP-MYST3 fusion transcripts have been identified in patients. We describe two new types of MYST3-CBP transcripts and a new primer set.
Murati
Anne
A
Adélaïde
José
J
Quilichini
Benoît
B
Rémy
Virginie
V
Sainty
Danielle
D
Stoppa
Anne-Marie
AM
Bernard
Philippe
P
Olschwang
Sylviane
S
Birnbaum
Daniel
D
Chaffanet
Max
M
Mozziconacci
Marie-Joëlle
MJ
D000368:Aged; D002352:Carrier Proteins / Q000235:genetics*; D002885:Chromosomes, Human, Pair 16; D002898:Chromosomes, Human, Pair 8; D003345:Corticosterone; D017931:DNA Primers / Q000737:chemistry; D005260:Female; D051548:Histone Acetyltransferases / Q000235:genetics*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D015514:Oncogene Proteins, Fusion / Q000096:biosynthesis / Q000235:genetics*; D011379:Prognosis; D020133:Reverse Transcriptase Polymerase Chain Reaction / Q000379:methods*; D014178:Translocation, Genetic
D002352:Carrier Proteins; D017931:DNA Primers; D015514:Oncogene Proteins, Fusion; D051548:Histone Acetyltransferases; C108712:KAT6A protein, human; D003345:Corticosterone