[Immunogenetic analysis of pathomorphological forms and prognosis of chronic glomerulonephritis].
OBJECTIVE
To ascertain whether HLA antigens are associated with morphological forms of chronic glomerulonephritis (CGN).


METHODS
A retrospective analysis was made of HLA distribution in 122 patients with proliferative and nonproliferative forms of CGN at different stages of fibroplastic transformation and addition of the tubulointerstitial component. Testing of HLA antigens of class I was conducted by lymphocytotoxicity; specificity of DRBI genes was investigated by DNA polymerase chain reaction. The control group consisted of 341 healthy citizens of Novosibirsk.


RESULTS
HLA-associations typical for each morphological CGN form, characteristic differences between them were established.


CONCLUSIONS
The tables were plotted allowing estimation of probability of each of CGN morphological forms.
Korotkova
I Iu
IIu
Valentik
M F
MF
Movchan
E A
EA
Telegina
T A
TA
Maksimov
V S
VS
Ivanova
G G
GG
Konenkov
V I
VI
D001706:Biopsy; D002908:Chronic Disease; D003937:Diagnosis, Differential; D005805:Genes, MHC Class I / Q000235:genetics; D005921:Glomerulonephritis / Q000175:diagnosis / Q000235:genetics / Q000276:immunology / Q000473:pathology; D006680:HLA Antigens / Q000235:genetics* / Q000276:immunology; D006684:HLA-DR Antigens / Q000235:genetics / Q000276:immunology; D059811:HLA-DRB1 Chains; D006801:Humans; D007668:Kidney / Q000473:pathology*; D010641:Phenotype; D016133:Polymerase Chain Reaction; D011379:Prognosis; D012189:Retrospective Studies
D006680:HLA Antigens; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains