The role of simvastatin on postoperative peritoneal adhesion formation in an animal model.
OBJECTIVE
The aim of this study is to show the effect of simvastatin on intra-abdominal adhesion formation.


METHODS
Adhesion formation was achieved by scratching the cecum and anterior abdominal wall following median laparotomy. Three different groups of 10 rats each were formed. In group I, 0.57 mg/kg/day simvastatin was injected intraperitoneally right after the operation and for 5 days thereafter. In group II, an equal dose of simvastatin to that used in group I was given via gavage. A physiological saline solution was given to group III for the same period of time. On the 6th and 14th day, blood samples were taken and peritoneal lavage was performed to measure the tissue-type plasminogen activator (t-PA) activity. Adhesions were graded via re-laparotomies on the 14th day after the first operation.


RESULTS
The adhesion scores were 1.40 +/- 0.22, 1.50 +/- 0.26, and 2.90 +/- 0.34 in groups I, II, and III, respectively (p = 0.007), and the score was higher in group III than in the other groups (p = 0.005, p = 0.011).


CONCLUSIONS
Intraperitoneal simvastatin application decreases adhesion formation by increasing the t-PA level in abdominal surgery.
Kucuk
Hasan Fehmi
HF
Kartal Research and Education Hospital, Istanbul, Turkey. hasan.kucuk@sbkeah.gov.tr
Kaptanoglu
Levent
L
Kurt
Necmi
N
Uzun
Huseyin
H
Eser
Mehmet
M
Bingul
Sadik
S
Torlak
Oguzhan Aziz
OA
Akyol
Huseyin
H
D034861:Abdominal Wall / Q000601:surgery; D000818:Animals; D002432:Cecum / Q000601:surgery; D013505:Digestive System Surgical Procedures / Q000009:adverse effects*; D004195:Disease Models, Animal; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D008297:Male; D010529:Peritoneal Cavity / Q000601:surgery; D010533:Peritoneal Lavage; D011183:Postoperative Complications / Q000188:drug therapy / Q000517:prevention & control; D051381:Rats; D017208:Rats, Wistar; D019821:Simvastatin / Q000494:pharmacology*; D000267:Tissue Adhesions / Q000188:drug therapy* / Q000517:prevention & control*; D010959:Tissue Plasminogen Activator / Q000097:blood
D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D019821:Simvastatin; D010959:Tissue Plasminogen Activator