title: Modulation of innate and adaptive immunity by lactoferrin in human immunodeficiency virus (HIV)-infected, antiretroviral therapy-naïve children.
abstract: Oral lactoferrin supplementation in human immunodeficiency virus (HIV)-infected, antiretroviral therapy-naïve children resulted in a skewing of T-lymphocytes towards more differentiated subpopulations. Phagocytosis (P=0.01) and killing (P=0.009), Toll-like receptor 2 expression (P=0.01) and the interleukin-12/interleukin-10 ratio (P=0.001) were also improved by lactoferrin. Lactoferrin supplementation results in immune modulation and could be useful in HIV infection.
authors.affiliation: Paediatrics, University of Milan, Milan, Italy.
authors.forename: Gian Vincenzo
authors.initials: GV
authors.lastname: Zuccotti
authors.forename: Alessandra
authors.initials: A
authors.lastname: Vigano
authors.forename: Manuela
authors.initials: M
authors.lastname: Borelli
authors.forename: Marina
authors.initials: M
authors.lastname: Saresella
authors.forename: Vania
authors.initials: V
authors.lastname: Giacomet
authors.forename: Mario
authors.initials: M
authors.lastname: Clerici
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000818:Animals; D019380:Anti-HIV Agents / Q000008:administration & dosage; D002417:Cattle; D002648:Child; D002675:Child, Preschool; D015658:HIV Infections / Q000188:drug therapy* / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate / Q000187:drug effects*; D007781:Lactoferrin / Q000008:administration & dosage*; D016176:T-Lymphocyte Subsets / Q000187:drug effects / Q000276:immunology
chemical_list: D019380:Anti-HIV Agents; D007781:Lactoferrin