Massive ibuprofen overdose requiring extracorporeal membrane oxygenation for cardiovascular support.
OBJECTIVE
Ibuprofen is rarely associated with severe toxicity. We report a massive ibuprofen overdose that resulted in refractory hypotension requiring extracorporeal membrane oxygenation (ECMO) for cardiovascular support.


METHODS
Individual case report.


METHODS
Pediatric intensive care unit of a tertiary care hospital.


METHODS
A 14-yr-old male presented with apnea and cardiovascular collapse after a nonaccidental ingestion of approximately 50 g of ibuprofen. His laboratory evaluation demonstrated an anion gap metabolic acidosis and elevated lactate levels.


METHODS
The patient required pressor support with norepinephrine, phenylephrine, and vasopressin infusions. Due to refractory hypotension, he was placed on ECMO. His serum ibuprofen level at an estimated 5-10 hrs postingestion was 776 microg/mL (therapeutic 20-30 microg/mL). Urine toxicological screen for drugs of abuse, serum acetaminophen, salicylate, and carboxyhemoglobin levels showed that these levels were not elevated. The patient developed high-output renal failure, pulmonary hemorrhage, and gastric bleeding, all of which resolved by hospital day 3.


RESULTS
ECMO was discontinued on hospital day 4, inotropic support was discontinued, and the patient was extubated on hospital day 5. He was transferred to an inpatient psychiatric unit on hospital day 9 with no identifiable medical sequelae.


CONCLUSIONS
Although ibuprofen overdose typically has few consequences, severe hypotension, renal failure, and gastrointestinal bleeding can occur. We report the first known case of successful ECMO therapy for ibuprofen overdose.
Marciniak
Kira E
KE
University of Washington School of Medicine, Seattle, WA, USA.
Thomas
Ildiko H
IH
Brogan
Thomas V
TV
Roberts
Joan S
JS
Czaja
Angela
A
Mazor
Suzan S
SS
D000293:Adolescent; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000506:poisoning*; D015199:Extracorporeal Membrane Oxygenation; D006801:Humans; D007052:Ibuprofen / Q000506:poisoning*; D008297:Male; D013406:Suicide, Attempted
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007052:Ibuprofen