title: Contribution of dust mite and cat specific IgE to total IgE: relevance to asthma prevalence.
abstract: BACKGROUND
  The prevalence of asthma is strikingly different in some Westernized countries: approximately 20% in New Zealand and approximately 8% in northern Sweden.
  
  
  OBJECTIVE
  We investigated differences in total IgE and in the prevalence of wheezing related to the observation that high exposure to dust mite allergens induces high titers of IgE antibodies.
  
  
  METHODS
  Two age-matched, population-based cohorts-1155 children in New Zealand (224 sera) and 3431 children (797 sera) in the Norrbotten area of Sweden-were studied. Sera were assayed for total IgE and specific IgE antibodies to relevant allergens.
  
  
  RESULTS
  The mean total IgE among wheezing children was higher in New Zealand than Sweden (218 IU/mL vs 65.2 IU/mL; P < .001). In addition, the prevalence of high titer specific IgE antibody (> or =50 IU/mL) was greater among the wheezing children in New Zealand compared with Sweden (35.7% vs 13.0%; P < .001). Specific IgE antibody to mite in New Zealand was significantly related to high total IgE (> or =200 IU/mL; r = 0.47; P < .001), whereas the IgE antibody response to cat allergens did not make a significant contribution to high total IgE in either country.
  
  
  CONCLUSIONS
  The quantity of IgE antibody produced to dust mite provides a possible explanation for the higher total IgE levels found in children in New Zealand and may help to explain the differences in prevalence and severity of asthma between these 2 countries.
  
  
  CONCLUSIONS
  Specific IgE antibody responses to dust mite and cat allergens may contribute differently to total serum IgE and to the prevalence of allergic disease.
authors.affiliation: University of Virginia Asthma and Allergic Diseases Center, Charlottesville, VA, USA.
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Erwin
authors.forename: Eva
authors.initials: E
authors.lastname: Rönmark
authors.forename: Kristin
authors.initials: K
authors.lastname: Wickens
authors.forename: Matthew S
authors.initials: MS
authors.lastname: Perzanowski
authors.forename: David
authors.initials: D
authors.lastname: Barry
authors.forename: Bo
authors.initials: B
authors.lastname: Lundbäck
authors.forename: Julian
authors.initials: J
authors.lastname: Crane
authors.forename: Thomas A E
authors.initials: TA
authors.lastname: Platts-Mills
mesh_terms: D000818:Animals; D001249:Asthma / Q000453:epidemiology* / Q000209:etiology; D002415:Cats / Q000276:immunology*; D002648:Child; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood*; D015995:Prevalence; D039981:Pyroglyphidae / Q000276:immunology*; D012135:Respiratory Sounds / Q000209:etiology
chemical_list: D007073:Immunoglobulin E