[Helicobacter pylori and symptoms of gastroesophageal reflux in adolescents: role of cagA-comprising strains].
The objective of this study was to assess the prevalence of gastroesophageal reflux symptoms (GERS) in 403 adolescents at the age of 14-17 according to the Helicobacter pylori status in a two-year prospective school-based survey. Initially the H. pylori infection was revealed in 55.3%. GERS were reported by 16.1% of H. pylori negative subjects, 17.3% of H. pylori positive but CagA negative adolescents, and by 30.3% of those being CagA positive. Over 2 years, among 275 subjects without initial GERS, symptoms appeared in 43 (15.6%), being 10.8%, 18.8%, and 21.0% in three groups under the study, respectively. The H. pylori infection (especially with CagA positive strains) in older children results in GERS, which can be explained by antral gastritis with a subsequent increase of acid secretion.
Reshetnikov
O V
OV
Kurilovich
S A
SA
Krotova
V A
VA
Krotov
S A
SA
D000293:Adolescent; D000942:Antigens, Bacterial / Q000235:genetics*; D001426:Bacterial Proteins / Q000235:genetics*; D002648:Child; D004269:DNA, Bacterial / Q000032:analysis*; D005260:Female; D005764:Gastroesophageal Reflux / Q000175:diagnosis / Q000453:epidemiology*; D016481:Helicobacter Infections / Q000175:diagnosis*; D016480:Helicobacter pylori / Q000235:genetics / Q000302:isolation & purification / Q000472:pathogenicity*; D006801:Humans; D008297:Male; D015995:Prevalence; D012306:Risk; D012426:Russia / Q000453:epidemiology; D014774:Virulence / Q000235:genetics
D000942:Antigens, Bacterial; D001426:Bacterial Proteins; D004269:DNA, Bacterial; C080866:cagA protein, Helicobacter pylori