A large scale synthesis of a natural antibiotic, 2,4-diacetylophloroglucinol (DAPG).
A natural antibiotic, 2,4-diacetylophloroglucinol (DAPG), has been prepared by the acetylation of phloroglucinol (PhL) with acetic anhydride in the presence of boron trifluoride etherate complex. The crude DAPG is efficiently purified using chromatographic filtration with boiling eluent.
Zakrzewski
Jerzy
J
Institute of Industrial Organic Chemistry, Warsaw, Poland. zakrzewski@ipo.waw.pl
Karpińska
Monika
M
Maliński
Zbigniew
Z
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry; D010696:Phloroglucinol / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000737:chemistry
D000900:Anti-Bacterial Agents; C059817:2,4-diacetylphloroglucinol; D010696:Phloroglucinol