title: Imaging cerebral amyloid angiopathy with susceptibility-weighted imaging.
abstract: Gradient-echo (GE) imaging is recognized as a means to detect hemorrhagic changes in cerebral amyloid angiopathy (CAA). However, almost 25% of patients with CAA do not show microhemorrhages on T2* GE imaging. We applied a new imaging method, susceptibility weighted imaging (SWI), to evaluate the presence of microhemorrhages. In a suspected case of CAA, where cognitive effects are also present, we show that SWI is much more sensitive in detecting microhemorrhages than conventional methods.
authors.affiliation: Institute for Biomedical Research, Detroit, Mich, USA.
authors.forename: E M
authors.initials: EM
authors.lastname: Haacke
authors.forename: Z S
authors.initials: ZS
authors.lastname: DelProposto
authors.forename: S
authors.initials: S
authors.lastname: Chaturvedi
authors.forename: V
authors.initials: V
authors.lastname: Sehgal
authors.forename: M
authors.initials: M
authors.lastname: Tenzer
authors.forename: J
authors.initials: J
authors.lastname: Neelavalli
authors.forename: D
authors.initials: D
authors.lastname: Kido
mesh_terms: D000368:Aged; D016657:Cerebral Amyloid Angiopathy / Q000473:pathology*; D002544:Cerebral Infarction / Q000473:pathology*; D002560:Cerebrovascular Circulation; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008833:Microcirculation