Chemistry and biology of resorcylic acid lactones.
While resorcylic acid lactones (RALs) have been known for a long time, the more recent discoveries that radicicol is a potent and selective HSP90 inhibitor while other members such as hypothemycin, LL-Z1640-2 and LL-783,277 are potent kinase inhibitors have stimulated a renewed interest in this family of natural products. The recent developments regarding the chemistry and biology of RALs are reviewed.
Winssinger
Nicolas
N
Organic and Bioorganic Chemistry Laboratory, Institut de Science et Ingénierie Supramoléculaires, Université Louis Pasteur, 8 allée Gaspard Monge, 67000, Strasbourg, France. winssinger@isis-u.strasbg.fr
Barluenga
Sofia
S
D018841:HSP90 Heat-Shock Proteins / Q000037:antagonists & inhibitors; D062385:Hydroxybenzoates / Q000737:chemistry*; D007783:Lactones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D047028:Macrocyclic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D018942:Macrolides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D020928:Mitogen-Activated Protein Kinases / Q000037:antagonists & inhibitors; D015394:Molecular Structure; D009183:Mycotoxins / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D015025:Zearalenone / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology
D018841:HSP90 Heat-Shock Proteins; D062385:Hydroxybenzoates; C118715:LL Z1640-2; D007783:Lactones; D047028:Macrocyclic Compounds; D018942:Macrolides; D009183:Mycotoxins; C120440:hypothemycin; D015025:Zearalenone; D020928:Mitogen-Activated Protein Kinases; C035359:monorden; C017704:beta-resorcylic acid