Dynamic kinetic resolution of primary amines with a recyclable Pd nanocatalyst for racemization.
A practical procedure for the dynamic kinetic resolution (DKR) of primary amines has been developed. This procedure employs a palladium nanocatalyst as the racemization catalyst, a commercial lipase (Novozym-435) as the resolution catalyst, and ethyl acetate or ethyl methoxyacetate as the acyl donor. Eleven primary amines and one amino acid amide have been efficiently resolved with good yields (85-99%) and high enantiomeric excesses (97-99%). [reaction: see text]
Kim
Mahn-Joo
MJ
Department of Chemistry, Pohang University of Science and Technology, San-31, Hyojadong, Pohang 790-784, Korea. mjkim@postech.ac.kr
Kim
Won-Hee
WH
Han
Kiwon
K
Choi
Yoon Kyung
YK
Park
Jaiwook
J