title: Dietary exposure to copper in the European Union and its assessment for EU regulatory risk assessment.
abstract: EU legislation requires a multimedia exposure assessment for substances supplied within the EU. Dietary intake is the main source of exposure for the majority of the population hence an essential component of the human risk assessment. This paper describes the available data for dietary copper and its use in estimating daily intake including variability and determinants of exposure. Typical and reasonable worst-case estimates are derived for the general population from the available peer reviewed literature. Intakes from drinking water are found to exhibit more variability than those from food. Therefore, different exposure scenarios are derived to reflect the range of acute and chronic exposures that may occur. Estimates of typical copper intakes for the EU population are in the range 0.8-1.8 mg/day. Typical copper intakes of men are higher than those of women while the intake among the general adult population is higher than that of the elderly. Intakes of both men and women are generally close to the WHO normative requirements but may be somewhat lower in specific locations where background levels of copper are unusually low. Alcoholic beverages represent minor contribution daily copper intakes. Intakes for children are rather variable ranging broadly from 0.7 to 1.5 mg/day and are somewhat age and sex dependent. Greater uncertainty applies to the assessment of local exposure incorporating food produced on land directly impacted by contemporary copper industry emissions. Specifically, the extent to which soil is enriched in copper in these conditions is unclear. However, effective homeostatic control mechanisms in plants limit uptake and transfer to the human food chain. A best estimate of 0.25 mg/day in addition to regional exposure was derived. Drinking water is estimated to contribute only marginally to total copper intake in most cases. Higher intakes may occur in areas of poor water quality and/or corroded distribution systems. Such elevated exposures appear unusual but their frequency is unknown.
authors.affiliation: Institute of Occupational and Environmental Medicine, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK. s.sadhra@bham.ac.uk
authors.forename: Steven S
authors.initials: SS
authors.lastname: Sadhra
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Wheatley
authors.forename: Hilary J
authors.initials: HJ
authors.lastname: Cross
mesh_terms: D003300:Copper / Q000032:analysis*; D004032:Diet; D004781:Environmental Exposure / Q000032:analysis*; D004784:Environmental Monitoring; D004785:Environmental Pollutants / Q000032:analysis*; D005062:European Union; D005506:Food Contamination / Q000032:analysis; D006801:Humans; D018570:Risk Assessment; D014881:Water Supply / Q000032:analysis
chemical_list: D004785:Environmental Pollutants; D003300:Copper