title: Familial Churg-Strauss syndrome in two sisters.
abstract: Churg-Strauss syndrome (CSS) is an uncommon systemic vasculitis with an increase in the number of eosinophils in the peripheral blood and tissues. Its pathogenesis is unknown, and there is no evidence that genetic factors influence susceptibility to this disease. We present a case of familial CSS in two sisters with atopic-type bronchial asthma and negative perinuclear anti-neutrophil cytoplasmic antibody results. We investigated the human leukocyte antigen typing of the sisters and their six living siblings but found no evidence for heritability of CSS. To our knowledge, this is the first report of familial CSS.
authors.affiliation: Clinical Research Center for Allergy and Rheumatology, National Hospital Organization Sagamihara National Hospital, Sagamihara, Kanagawa, Japan. n-tsurikisawa@sagamihara-hosp.gr.jp
authors.forename: Naomi
authors.initials: N
authors.lastname: Tsurikisawa
authors.forename: Sonoko
authors.initials: S
authors.lastname: Morita
authors.forename: Takahiro
authors.initials: T
authors.lastname: Tsuburai
authors.forename: Chiyako
authors.initials: C
authors.lastname: Oshikata
authors.forename: Emiko
authors.initials: E
authors.lastname: Ono
authors.forename: Masami
authors.initials: M
authors.lastname: Taniguchi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Saito
authors.forename: Yukiyoshi
authors.initials: Y
authors.lastname: Yanagihara
authors.forename: Kazuo
authors.initials: K
authors.lastname: Akiyama
mesh_terms: D000368:Aged; D015267:Churg-Strauss Syndrome / Q000235:genetics*; D005260:Female; D006650:Histocompatibility Testing; D006801:Humans; D008875:Middle Aged; D035781:Siblings