Sleep-related minor motor events in nocturnal frontal lobe epilepsy.
OBJECTIVE
Nocturnal frontal lobe epilepsy (NFLE) is characterized by a wide spectrum of sleep-related motor manifestations of increasing complexity, ranging from major episodes to brief motor events (minor motor events, MMEs). NFLE patients may exhibit a large quantity of MMEs in the form of short-lasting stereotyped movements. Whereas major episodes are considered epileptiform manifestations, it remains unclear whether the MMEs are related to epileptiform discharges (EDs).


METHODS
To study the relation between EDs and the occurrence of MMEs, we report a detailed neurophysiolgical evaluation in NFLE subjects explored by using implanted electrodes.


RESULTS
The median value of ED-related movements was 71.8%. Motor expression in relation to epileptiform discharge was surprisingly variable; no peculiar expression of MMEs could be attributed to the presence of EDs.


CONCLUSIONS
Our data suggest that ED-associated MMEs are extremely polymorphous, and no univocal relation to EDs can be identified. We hypothesize that MMEs are not a direct effect of epileptiform discharge (i.e., not epileptic in origin), but the result of aspecific disinhibition of innate motor patterns. We warn clinicians that the epileptic nature of minimal motor phenomena in NFLE cannot be established on the clinical phenomenology of the event.
Terzaghi
Michele
M
Sleep Medicine and Epilepsy Unit, IRCCS C. Mondino Institute of Neurology Foundation, Pavia, Italy. michele.terzaghi@mondino.it
Sartori
Ivana
I
Mai
Roberto
R
Tassi
Laura
L
Francione
Stefano
S
Cardinale
Francesco
F
Castana
Laura
L
Cossu
Massimo
M
LoRusso
Giorgio
G
Manni
Raffaele
R
Nobili
Lino
L
D000328:Adult; D002940:Circadian Rhythm / Q000502:physiology; D015897:Comorbidity; D003937:Diagnosis, Differential; D004567:Electrodes, Implanted; D004569:Electroencephalography; D017034:Epilepsy, Frontal Lobe / Q000175:diagnosis* / Q000453:epidemiology / Q000503:physiopathology; D005260:Female; D007839:Functional Laterality; D006801:Humans; D008297:Male; D020183:Nocturnal Paroxysmal Dystonia / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology; D017286:Polysomnography; D020178:Sleep Disorders, Circadian Rhythm / Q000175:diagnosis* / Q000453:epidemiology; D019956:Stereotypic Movement Disorder / Q000175:diagnosis* / Q000453:epidemiology / Q000503:physiopathology; D014743:Videotape Recording