title: [Analysis of healing in the Alba Linea with the use of Orbignya phalerata (babassu) water extract. Controlled study in rats].
abstract: BACKGROUND
  The babassu mesocarp (Orbignya phalerata) has been used in experimental research studies focused on its antiinflammatory action. In state of Maranhão--Brazil it is widely used not only as food, but also as popular medicine in wound healing process.
  
  
  OBJECTIVE
  To evaluate the action of Orbignya phalerata extract in macroscopic, histologic and tensiometric aspects in the healing process of median laparotomy in rats.
  
  
  METHODS
  Forty male adult Wistar rats were submitted to an incision in the alba linea, sutured back in one plan with separated stitches of polypropylene 5-0. After regular procedure, the animals were divided into two groups of 20 rats each. To the group named control an intraperitoneal, dose of 1.0 ml of saline solution per kilogram of body weight was done. To the experimental group, the same thing was also done, but instead of saline solution it was injected water solution of babassu, in a dose of 50 mg/kg. The animals were observed in the following days. All of them were killed within a three and seven day post-operative period schedule, and then a histological and tensiometric analysis was carried out.
  
  
  RESULTS
  On macroscopic examination no relevant adherence, between the alba linea and the abdominal organs in the study groups, was found. Histological evaluation presented marginal significant effects (p=0.86) to acute inflammation and significant effects (p=0.003) to giant cell reaction in both control and experimental three days groups. Significant difference was observed to acute inflammation in both seven days control and experimental groups. In the intragroup analysis (control three and seven) some marginal significant effect was in relationship to acute and chronic inflammation. In the inter-experimental groups analysis, only the giant cell reactions (0.002) and colagenization had significant results. The tensiometric evaluation showed in the seven day experimental group more resistance then others.
  
  
  CONCLUSIONS
  The macroscopic and histological evaluation didn't show any significant difference between the experimental and control groups, but the tensiometric evaluation at the 7th day experimental group had significant difference compared to the control group, signaling that the use of the extract of babassu intraperitoneally injected can improve the healing process.
authors.affiliation: Universidade Federal do Maranhao.
authors.forename: Sebastião Barreto de
authors.initials: SB
authors.lastname: Brito Filho
authors.forename: Jorge Eduardo F
authors.initials: JE
authors.lastname: Matias
authors.forename: Henrique Jorge
authors.initials: HJ
authors.lastname: Stahlke Júnior
authors.forename: Orlando Jorge Martins
authors.initials: OJ
authors.lastname: Torres
authors.forename: Jorge Rufino Ribas
authors.initials: JR
authors.lastname: Timi
authors.forename: Sérgio Bernardo
authors.initials: SB
authors.lastname: Tenório
authors.forename: Elizabeth Milla
authors.initials: EM
authors.lastname: Tâmbara
authors.forename: Angelo G
authors.initials: AG
authors.lastname: Carstens
authors.forename: Richard Vieira
authors.initials: RV
authors.lastname: Campos
authors.forename: Márcio
authors.initials: M
authors.lastname: Myamoto
mesh_terms: D034861:Abdominal Wall / Q000473:pathology / Q000601:surgery*; D000704:Analysis of Variance; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D003059:Cocos / Q000737:chemistry*; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D007249:Inflammation / Q000188:drug therapy; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D018709:Statistics, Nonparametric; D013536:Suture Techniques; D013718:Tensile Strength / Q000187:drug effects; D013997:Time Factors; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D000893:Anti-Inflammatory Agents; D010936:Plant Extracts