title: Myriaporones 1-4, cytotoxic metabolites from the Mediterranean bryozoan Myriapora truncata.
abstract: Four novel polyketide-derived metabolites, myriaporones 1, 2, 3, and 4, have been isolated from the Mediterranean bryozoan Myriapora truncata. Their structures and stereochemistry have been assigned from the analysis of spectroscopic data. The inseparable equilibrium mixture of myriaporones 3 and 4 showed 88% inhibition of L1210 murine leukemia cells at 0.2 microg/mL.
authors.affiliation: Roger Adams Laboratory, University of Illinois, Urbana, IL 61801, USA. jcheng@trlusa.com
authors.forename: Jie-Fei
authors.initials: JF
authors.lastname: Cheng
authors.forename: Jong-Soo
authors.initials: JS
authors.lastname: Lee
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Sakai
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Jares-Erijman
authors.forename: Maria V
authors.initials: MV
authors.lastname: Silva
authors.forename: Kenneth L
authors.initials: KL
authors.lastname: Rinehart
mesh_terms: D000475:Alkenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002013:Bryozoa / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D004852:Epoxy Compounds / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D007939:Leukemia L1210; D008522:Mediterranean Sea; D051379:Mice; D015394:Molecular Structure; D011714:Pyrans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D000475:Alkenes; D000970:Antineoplastic Agents; D004852:Epoxy Compounds; D011714:Pyrans; C476087:myriaporone 1; C505861:myriaporone 2; C505858:myriaporone 3; C505860:myriaporone 4