Macrophage inflammatory protein-1alpha: a link between innate immunity and familial Mediterranean fever?
The aim of this study is to investigate the relationship between chemokines and the inflammation in Familial Mediterranean Fever (FMF). Forty-nine patients with FMF (41 in remission and 8 in acute attack period) and 20 healthy controls were included in the study. Serum levels of macrophage inflammatory protein-1alpha (MIP-1alpha) were assessed in the patients and the controls, along with other parameters of disease activity, i.e., fibrinogen, C-reactive protein and erythrocyte sedimentation rate. Serum MIP-1alpha levels of the patients with FMF in acute attack period were significantly higher than the patients in remission and healthy controls (p=0.02 and p=0.038, respectively). MIP-1alpha levels were weakly correlated with CRP (r=0.32, p=0.032) levels. MIP-1alpha may have a role in the pathogenesis of FMF attacks. MIP-1alpha and other chemokines may constitute a link between the innate immune system and FMF.
Dizdar
Omer
O
Hacettepe University Faculty of Medicine, Department of Internal Medicine, Division of Medical Oncology, 06100 Sihhiye, Ankara, Turkey. omerdiz@yahoo.com
Kalyoncu
Umut
U
Karadag
Omer
O
Akdogan
Ali
A
Kiraz
Sedat
S
Ertenli
Ihsan
I
Barista
Ibrahim
I
Calguneri
Meral
M
D000293:Adolescent; D000328:Adult; D054405:Chemokine CCL3; D054407:Chemokine CCL4; D010505:Familial Mediterranean Fever / Q000097:blood* / Q000276:immunology* / Q000473:pathology; D005260:Female; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology*; D019402:Macrophage Inflammatory Proteins / Q000097:blood*; D008297:Male; D008875:Middle Aged
D054405:Chemokine CCL3; D054407:Chemokine CCL4; D019402:Macrophage Inflammatory Proteins