1.8 cineole decreases gastric compliance in anesthetized rats.
OBJECTIVE
To study the effect of 1,8 cineole components of the essential oil of Croton nepetaefolius--plant of North-East of Brasil, used in the popular medicine for riots of the gastrointestinal tract--on the motor behavior of the gut of Wistar rats.


METHODS
Used 16 male animals under jejun of 24h weighing 300-350 g. The effect of 1.8 cineole (1 or 3mg/Kg) on gastric compliance had been lead in anaesthetized rats. The variations of the gastric volume (GV), had been measured by plethysmography, while AP, HR and CVP had been monitored continuously by a digital system of data acquisition.


RESULTS
Observe reduction of the GV, which was significant on 30, 40, 50 and 60 min after treatment (2.0 +/- 0.1; 1.9 +/- 0.1; 1.8 +/- 0.1 and 1.7 +/- 0.1mL, versus 2.1 +/- 0.2mL). The AP presented significant fall after the administration of 1.8 cineole, remaining thus during 60min of monitorization (87.9 +/- 7.7; 87.6 +/- 7.1; 87.9 +/- 6.4; 87.8 +/- 5.7; 86.0 +/- 5.5 and 87.7 +/- 6.0mmHg, respectively versus 94.4 +/- 6.2 mmHg), as well as the HR (366.3 +/- 13.4; 361.7 +/- 11.5; 357.3 +/- 10.4; 353.0 +/- 10.4; 348.3 +/- 11.1 and 350.4 +/- 13.7bpm, respectively versus 395.2 +/- 11.1bpm). The CVP did not suffer significant variations after treatment.


CONCLUSIONS
Observe the 1.8 cineole reduces the gastric compliance in anaesthetized rats besides presenting effect hypotensor and bradycardia; probably for direct action on the gastrointestinal and vascular smooth muscle and moduling the autonomic nervous system.
Neves
José Ricardo Cunha
JR
Laboratory School Prof. Luiz Capelo, Department of Physiology and Pharmacology of the College of Medicine, Federal University of Ceará, Brazil.
Lira
Gislano Heverton Soares de
GH
Oliveira Neto
Rocino Marinho de
RM
Graça
José Ronaldo Vasconcelos da
JR
Vasconcelos
Paulo Roberto Leitão de
PR
Nobre e Souza
Miguel Angelo
MA
Magalhães
Pedro Jorge Caldas
PJ
Rola
Francisco Hélio
FH
Santos
Armênio Aguiar dos
AA
D000704:Analysis of Variance; D000768:Anesthesia, General; D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D002496:Central Venous Pressure / Q000187:drug effects; D003187:Compliance / Q000187:drug effects; D003436:Croton Oil / Q000494:pharmacology*; D003511:Cyclohexanols / Q000494:pharmacology; D000077591:Eucalyptol; D015905:Gastric Balloon; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D023421:Models, Animal; D039821:Monoterpenes / Q000494:pharmacology; D010991:Plethysmography; D051381:Rats; D017208:Rats, Wistar; D013270:Stomach / Q000187:drug effects* / Q000502:physiology; D013997:Time Factors
D000890:Anti-Infective Agents; D003511:Cyclohexanols; D039821:Monoterpenes; D003436:Croton Oil; D000077591:Eucalyptol