title: Application of t1 and t2 maps for stereotactic deep-brain neurosurgery planning.
abstract: This work presents the application of a quantitative magnetic resonance imaging (MRI) technique in stereotactic deep-brain neurosurgery planning procedures. The high spatial resolution T<inf>1</inf>and T<inf>2</inf>maps acquired using this imaging method have been normalized to the standard CJH-27 brain coordinate system and integrated into a neurosurgical visualization and navigation system to improve the accuracy of surgical target localization. The T<inf>1</inf>and T<inf>2</inf>maps, along with the standardized anatomical and functional information within this system, can be navigated, non-rigidly registered, and arbitrarily processed. Once applied to individual patients, these maps facilitate the delineation of surgical targets. Our preliminary studies compared the centroids of segmented deep-brain nuclei based on the T<inf>1</inf>and T<inf>2</inf>maps with those according to Schaltenbrand and Wahren atlas, and with the actual surgical targets of 15 patients who had undergone thalamotomy, pallidotomy, and subthalamic nucleus deep-brain stimulation. The average displacement was 3.21mm&#177;0.80mm, indicating the potential capability of this system to accurately initiate target identifications.
authors.affiliation: Robarts Research Institute, London, ON, Canada.
authors.forename: T
authors.initials: T
authors.lastname: Guo
authors.forename: T
authors.initials: T
authors.lastname: Peters
authors.forename: S
authors.initials: S
authors.lastname: L Deoni
authors.forename: A
authors.initials: A
authors.lastname: Parrent
authors.forename: K
authors.initials: K
authors.lastname: Finnis