Lipoprotein (a) and apolipoprotein (a) in primary antiphospholipid syndrome.
OBJECTIVE
To investigate whether lipoprotein (a) (Lp(a)) and/or apolipoprotein (a) (apo(a)) may be markers for clinical features of 37 patients with primary antiphospholipid syndrome (PAPS) and to compare with 37 age- and sex-matched controls.


METHODS
Apo(a) and Lp(a) concentrations were determined by ELISA and immunonephelometry, respectively.


RESULTS
Only elevated apo(a) concentrations were significant predictor for cerebrovascular insults (OR=14.399, p=0.005, 95% CI: 2.224-93.230).


CONCLUSIONS
Considering the fact that PAPS patients with cerebrovascular insults had recurrence of cerebrovascular episodes, measurement of apo(a) concentrations will help in the follow-up of those patients and thus in the prediction of future episodes. This finding should be further investigated in a larger study in order to provide adequate therapeutic intervention.
Bećarević
Mirjana
M
Institute for Medical Biochemistry, Clinical Center of Serbia, Visegradska 26, 11000 Belgrade, Serbia. bmyrjana@yahoo.co.uk
Singh
Sandra
S
Majkić-Singh
Nada
N
D000328:Adult; D016736:Antiphospholipid Syndrome / Q000097:blood*; D001054:Apolipoproteins A / Q000097:blood*; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D017270:Lipoprotein(a) / Q000097:blood*; D008297:Male; D008875:Middle Aged
D001054:Apolipoproteins A; D017270:Lipoprotein(a)