title: Prothrombotic coagulation abnormalities in patients with newly diagnosed multiple myeloma.
abstract: Prothrombotic coagulation abnormalities were analyzed in patients with untreated multiple myeloma. Increases in factor VIII, in von Willebrand factor (vWF) and a decrease in protein S were observed and these changes were strongly associated with disease stage. No difference in baseline coagulation parameters was found between patients with and without subsequent venous thromboembolism.
authors.forename: Johannes J A
authors.initials: JJ
authors.lastname: Auwerda
authors.forename: Pieter
authors.initials: P
authors.lastname: Sonneveld
authors.forename: Monica P M
authors.initials: MP
authors.lastname: de Maat
authors.forename: Frank W G
authors.initials: FW
authors.lastname: Leebeek
mesh_terms: D000368:Aged; D017152:Antibodies, Antiphospholipid / Q000737:chemistry; D001777:Blood Coagulation; D001778:Blood Coagulation Disorders / Q000150:complications* / Q000175:diagnosis*; D016022:Case-Control Studies; D005169:Factor VIII / Q000096:biosynthesis; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000097:blood* / Q000175:diagnosis*; D017293:Protein S / Q000096:biosynthesis; D020246:Venous Thrombosis / Q000150:complications* / Q000175:diagnosis*; D014841:von Willebrand Factor / Q000096:biosynthesis
chemical_list: D017152:Antibodies, Antiphospholipid; D017293:Protein S; D014841:von Willebrand Factor; D005169:Factor VIII