Nanoparticle-mediated drug delivery and gene therapy.
Biomedical application of nanotechnology is a rapidly developing area that raises new prospect in the improvement of diagnosis and treatment of human diseases. The ability to incorporate drugs or genes into a functionalized nanoparticle demonstrates a new era in pharmacotherapy for delivering drugs or genes selectively to tissues or cells. It is envisioned that the transfer of nanoengineering capability into disease therapy will provide constant and concentrated drug delivery to targeted tissues, minimizing systemic side effects and toxicity. We have in this article highlighted the recent state of the art in nanomedicine, focusing particularly on the achievement of nanotechnology in nanoscale drug and gene delivery in vitro and in vivo. In addition, a specific emphasis has been placed on the use of nanotechnology to improve controlled drug release and sustainable drug delivery in solid tumors and on new drug therapies for age-related neurodegenerative disorders.
Jin
Sha
S
DNA Resource Center and Biomedical Engineering Program, College of Engineering, University of Arkansas, Fayetteville, Arkansas 72701, USA.
Ye
Kaiming
K
D004247:DNA / Q000008:administration & dosage* / Q000235:genetics*; D003692:Delayed-Action Preparations / Q000737:chemistry*; D015316:Genetic Therapy / Q000639:trends*; D050997:Nanomedicine / Q000639:trends*; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure*
D003692:Delayed-Action Preparations; D004247:DNA