Weak binding affinity of immunoglobin G, an explanation for the immune mimicking theory in pathophysiologic findings in the recovery phase of dengue.
The actual mechanisms underlying severe bleeding in dengue hemorrhagic fever (DHF) are not completely understood. The immune mimicking theory is a widely mentioned hypothesis that might help answer questions. In this study, the author performed a prediction on the binding affinity on the NS1 immunoglobulin (IgG and CD61-IgG) complexes using a computation medicine technique. According to this study, the significant discrimination of modeled Ig complexes can be detected. The finding, which is expected for the late recovery phase of dengue, implies the difficulty in mimicking immune complex formation.
Wiwanitkit
Viroj
V
Department of Laboratory Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. wviroj@pioneer.netserv.chula.ac.th <wviroj@pioneer.netserv.chula.ac.th>
D000915:Antibody Affinity / Q000276:immunology*; D032701:Biomimetics; D003715:Dengue / Q000276:immunology* / Q000473:pathology / Q000503:physiopathology*; D007074:Immunoglobulin G / Q000276:immunology*; D018448:Models, Immunological
D007074:Immunoglobulin G