Modeling mammary gland morphogenesis as a reaction-diffusion process.
Mammary ducts are formed through a process of branching morphogenesis. We present results of experiments using a simulation model of this process, and discuss their implications for understanding mammary duct extension and bifurcation. The model is a cellular automaton approximation of a reaction-diffusion process in which matrix metalloproteinases represent the activator, inhibitors of matrix metalloproteinases represent the inhibitor, and growth factors serve as a substrate. We compare results from the simulation model with those from in-vivo experiments as part of an assessment of whether duct extension and bifurcation during morphogenesis may be a consequence of a reaction-diffusion mechanism mediated by MMPs and TIMPs.
Grant
Mark R
MR
Joint UCSF/UCB Bioengineering Graduate Group, California Univ., Berkeley, CA, USA.
Hunt
C Anthony
CA
Xia
Lan
L
Fata
Jimmie E
JE
Bissell
Mina J
MJ