title: Clinical significance of circulating vascular endothelial growth factor in dogs with mammary gland tumors.
abstract: Increase in circulating vascular endothelial growth factor (VEGF) is suggested as a prognostic indicator in human patients with malignant tumors. The purpose of this study was to evaluate the clinical significance of circulating VEGF in dogs with mammary gland tumors (MGT). Both plasma and serum VEGF were significantly higher in dogs with MGT when compared with those in the healthy dogs. In dogs with MGT, the plasma and serum VEGF of the malignant group increased significantly compared with those of the benign group. Additionally, there was a significant difference between the plasma and serum VEGF in the groups with postoperative metastasis and no metastasis. Circulating VEGF is expected to be clinically available for the determination of prognosis in canine MGT.
authors.affiliation: Laboratory of Veterinary Surgery, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, Fujisawa, Kanagawa, Japan.
authors.forename: Yuka
authors.initials: Y
authors.lastname: Kato
authors.forename: Kazushi
authors.initials: K
authors.lastname: Asano
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Mogi
authors.forename: Kenji
authors.initials: K
authors.lastname: Kutara
authors.forename: Kenji
authors.initials: K
authors.lastname: Teshima
authors.forename: Kazuya
authors.initials: K
authors.lastname: Edamura
authors.forename: Shigehisa
authors.initials: S
authors.lastname: Tsumagari
authors.forename: Atsuhiko
authors.initials: A
authors.lastname: Hasegawa
authors.forename: Shigeo
authors.initials: S
authors.lastname: Tanaka
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000097:blood*; D004285:Dogs; D005260:Female; D015674:Mammary Neoplasms, Animal / Q000097:blood*; D009362:Neoplasm Metastasis; D011379:Prognosis; D042461:Vascular Endothelial Growth Factor A / Q000097:blood*
chemical_list: D042461:Vascular Endothelial Growth Factor A