Yeast endonuclease G: complex matters of death, and of life.
In a recent issue of Molecular Cell, Büttner et al. (2007) described dual roles for the conserved mitochondrial protein endonuclease G in budding yeast apoptosis and proliferation that illuminate some of the contradictory and confusing findings regarding this protein in mammalian cells.
Burhans
William C
WC
Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA. wburhans@acsu.buffalo.edu
Weinberger
Martin
M
D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D049109:Cell Proliferation; D004706:Endodeoxyribonucleases / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D004720:Endonucleases / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D008322:Mammals / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D008954:Models, Biological; D012441:Saccharomyces cerevisiae / Q000166:cytology / Q000201:enzymology* / Q000235:genetics; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*
D029701:Saccharomyces cerevisiae Proteins; D004706:Endodeoxyribonucleases; D004720:Endonucleases; C052391:endonuclease G