title: Immunomodulatory properties of mesenchymal stem cells: a review based on an interdisciplinary meeting held at the Kennedy Institute of Rheumatology Division, London, UK, 31 October 2005.
abstract: Multipotent mesenchymal stromal cells isolated from bone marrow and other sites are currently being studied to determine their potential role in the pathogenesis and/or management of autoimmune diseases. In vitro studies have shown that they exhibit a dose-dependent antiproliferative effect on T and B lymphocytes, dendritic cells, natural killer cells and various B cell tumour lines--an effect that is both cell contact and soluble factor dependent. Animal models of autoimmune disease treated with multipotent mesenchymal stromal cells have mostly exhibited a positive clinical response, as have a limited number of patients suffering from acute graft versus host disease. This review summarizes the findings of a 1-day meeting devoted to the subject with the aim of coordinating efforts.
authors.affiliation: Rheumatology, University Hospital Basel, Felix Platter Spital, Burgfelderstrasse 101, Basel, CH-4012, Switzerland. alan.tyndall@fps-basel.ch
authors.forename: Alan
authors.initials: A
authors.lastname: Tyndall
authors.forename: Ulrich A
authors.initials: UA
authors.lastname: Walker
authors.forename: Andrew
authors.initials: A
authors.lastname: Cope
authors.forename: Francesco
authors.initials: F
authors.lastname: Dazzi
authors.forename: Cosimo
authors.initials: C
authors.lastname: De Bari
authors.forename: Willem
authors.initials: W
authors.lastname: Fibbe
authors.forename: Serena
authors.initials: S
authors.lastname: Guiducci
authors.forename: Simon
authors.initials: S
authors.lastname: Jones
authors.forename: Christian
authors.initials: C
authors.lastname: Jorgensen
authors.forename: Katarina
authors.initials: K
authors.lastname: Le Blanc
authors.forename: Frank
authors.initials: F
authors.lastname: Luyten
authors.forename: Dennis
authors.initials: D
authors.lastname: McGonagle
authors.forename: Ivan
authors.initials: I
authors.lastname: Martin
authors.forename: Chiara
authors.initials: C
authors.lastname: Bocelli-Tyndall
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Pennesi
authors.forename: Vito
authors.initials: V
authors.lastname: Pistoia
authors.forename: Constantino
authors.initials: C
authors.lastname: Pitzalis
authors.forename: Antonio
authors.initials: A
authors.lastname: Uccelli
authors.forename: Nico
authors.initials: N
authors.lastname: Wulffraat
authors.forename: Marc
authors.initials: M
authors.lastname: Feldmann
mesh_terms: D000818:Animals; D001172:Arthritis, Rheumatoid / Q000276:immunology / Q000601:surgery; D003226:Congresses as Topic / Q000639:trends; D006801:Humans; D007155:Immunologic Factors / Q000276:immunology / Q000627:therapeutic use*; D008131:London; D045164:Mesenchymal Stem Cell Transplantation / Q000379:methods / Q000639:trends; D059630:Mesenchymal Stem Cells / Q000276:immunology*; D012219:Rheumatology / Q000379:methods* / Q000639:trends
chemical_list: D007155:Immunologic Factors