title: Huge nasopharyngeal angiofibroma with intracranial extension: change in the dura mater and choice of surgical management.
abstract: We aimed to review (1) the imaging changes in the dura mater in cases of huge, lobulated juvenile nasopharyngeal angiofibroma, and (2) the choice of surgical management. Imaging from four cases of juvenile nasopharyngeal angiofibroma showed extrapharyngeal extension of the tumour. The sphenoid sinus, sella turcica and clivus were extensively eroded, and the tumour had spread deep into the cranial fossa. In three cases, intracranial exploration was performed to treat the intracranial tumour lobule. Subsequently, the tumours were removed using extracranial approaches. No perforation of the dura mater was found in these three cases, although the dura mater in the superior orbital fissure was congested, haemorrhagic and solid. Pre-operative imaging for two cases (i.e. the first operation for one and the second operation for the other) revealed no dura mater perforation. A transantral approach via a midfacial degloving incision was used to remove these tumours completely. We conclude that change in the dura mater is a crucial indication for the choice of management. If the dura mater is intact, a transantral approach via a midfacial degloving incision may remove the tumour successfully.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, First Affiliated Hospital of Fujian Medical University, Otolaryngology Institute of Fujian Province, Fuzhou, China. yizixiang@sina.com.cn
authors.forename: Z X
authors.initials: ZX
authors.lastname: Yi
authors.forename: Z C
authors.initials: ZC
authors.lastname: Li
authors.forename: J M
authors.initials: JM
authors.lastname: Cheng
authors.forename: R
authors.initials: R
authors.lastname: Zhang
authors.forename: Chang
authors.initials: C
authors.lastname: Lin
authors.forename: A D
authors.initials: AD
authors.lastname: Zhou
authors.forename: Z M
authors.initials: ZM
authors.lastname: Fan
mesh_terms: D000293:Adolescent; D000328:Adult; D018322:Angiofibroma / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D004388:Dura Mater / Q000000981:diagnostic imaging*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009303:Nasopharyngeal Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D013517:Otorhinolaryngologic Surgical Procedures / Q000379:methods*; D014057:Tomography, X-Ray Computed