title: Segmental dyskinesia in Wolff-Parkinson-White syndrome: a possible cause of dilatative cardiomyopathy.
abstract: Wolff-Parkinson-White (WPW) is a syndrome characterized by the presence of an accessory pathway that skipping A-V node may lead the electrical stimulus from the atrium directly to the ventricle. Some studies reported the finding of myocardial dyskinesia in the segments precociously activated by the accessory pathway, at echocardiogram and at nuclear cardiac study. Soria et al. reported, in 1985, an increased incidence of dilative cardiomyopathy in patients with WPW. The pathophysiological pathway that leads to ventricular dilation may be due to the increase of end-diastolic pressure secondary to a tachycardia-induced cardiomyopathy. Tachycardia-induced cardiomyopathy is usually secondary to frequent and prolonged tachycardia episodes. In this paper we report the cases of three patients affected by WPW who developed dilative cardiomyopathy during the follow-up. Particularly dyskinetic segments, working such as a functional aneurysm, could induce deep modifications of intraventricular haemodynamics, leading to remodelling and progressive ventricular dilation. This hypothesis could have important empirical consequences because it could imply the necessity of a precocious ablative therapy in this kind of patients.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Fazio
authors.forename: Maurizio
authors.initials: M
authors.lastname: Mongiovi'
authors.forename: Loredana
authors.initials: L
authors.lastname: Sutera
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Novo
authors.forename: Salvatore
authors.initials: S
authors.lastname: Novo
authors.forename: Salvatore
authors.initials: S
authors.lastname: Pipitone
mesh_terms: D001145:Arrhythmias, Cardiac / Q000150:complications; D002311:Cardiomyopathy, Dilated / Q000209:etiology*; D002648:Child; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D014927:Wolff-Parkinson-White Syndrome / Q000150:complications*