High frequencies of clindamycin and tetracycline resistance in methicillin-resistant Staphylococcus aureus pulsed-field type USA300 isolates collected at a Boston ambulatory health center.
Individual or multiple resistance to clindamycin, tetracycline, erythromycin, levofloxacin, or mupirocin was detected in a large proportion of methicillin-resistant Staphylococcus aureus pulsed-field type USA300 isolates collected at an ambulatory health center in Boston. The clindamycin, tetracycline, and mupirocin resistance genes identified in these isolates are commonly associated with plasmids.
Han
Linda L
LL
State Laboratory Institute, 305 South St., Jamaica Plain, MA 02130, USA. linda.han@state.ma.us
McDougal
Linda K
LK
Gorwitz
Rachel J
RJ
Mayer
Kenneth H
KH
Patel
Jean B
JB
Sennott
Janet M
JM
Fontana
John L
JL
D000554:Ambulatory Care Facilities; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D015373:Bacterial Typing Techniques; D001900:Boston; D002981:Clindamycin / Q000494:pharmacology*; D016172:DNA Fingerprinting; D004269:DNA, Bacterial / Q000235:genetics; D024901:Drug Resistance, Multiple, Bacterial; D016521:Electrophoresis, Gel, Pulsed-Field; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D016106:Methicillin Resistance; D010957:Plasmids / Q000235:genetics; D013203:Staphylococcal Infections / Q000382:microbiology; D013211:Staphylococcus aureus / Q000145:classification / Q000187:drug effects* / Q000302:isolation & purification*; D013753:Tetracycline Resistance
D000900:Anti-Bacterial Agents; D004269:DNA, Bacterial; D002981:Clindamycin