Genetic risk for restenosis after coronary stenting.
OBJECTIVE
The purpose of the present study was to identify gene polymorphisms that confer susceptibility to restenosis after bare-metal stenting of coronary arteries, and thereby to predict the genetic risk for this condition.


RESULTS
The study population comprised 461 unrelated Japanese individuals (350 men, 111 women) who underwent stent implantation, including 107 subjects who developed in-stent restenosis and 354 subjects without this condition. The genotypes for 142 polymorphisms of 121 candidate genes were determined with a method that combines the polymerase chain reaction and sequence-specific oligonucleotide probes with suspension array technology. Multivariate logistic regression analysis with adjustment for the prevalence of diabetes mellitus revealed that the 1615G-->A polymorphism of BCHE, the 7,067,365C-->A polymorphism of INSR, the C-->T polymorphism of GPX1, the G-->A polymorphism of ROS1, and the G-->A polymorphism of MMP9 were associated (P<0.05) with in-stent restenosis. Further analysis with adjustment both for the prevalence of diabetes mellitus and for quantitative coronary angiographic measurements revealed that the BCHE, GPX1, and ROS1 genotypes were independently associated (P<0.05) with in-stent restenosis.


CONCLUSIONS
Determination of the genotypes for BCHE, GPX1, and ROS1 may prove informative for assessment of the genetic risk for in-stent restenosis.
Oguri
Mitsutoshi
M
Department of Cardiovascular Medicine, Gifu Prefectural Tajimi Hospital, 5-161 Maehata, Tajimi, Gifu 507-8522, Japan.
Kato
Kimihiko
K
Hibino
Takeshi
T
Yokoi
Kiyoshi
K
Segawa
Tomonori
T
Matsuo
Hitoshi
H
Watanabe
Sachiro
S
Nozawa
Yoshinori
Y
Murohara
Toyoaki
T
Yamada
Yoshiji
Y
D000368:Aged; D002091:Butyrylcholinesterase / Q000235:genetics*; D003324:Coronary Artery Disease / Q000235:genetics / Q000601:surgery*; D023903:Coronary Restenosis / Q000235:genetics*; D005260:Female; D005500:Follow-Up Studies; D020022:Genetic Predisposition to Disease; D005979:Glutathione Peroxidase / Q000235:genetics*; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011505:Protein-Tyrosine Kinases / Q000235:genetics*; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D015607:Stents / Q000009:adverse effects*; D000094765:Glutathione Peroxidase GPX1
D011518:Proto-Oncogene Proteins; D005979:Glutathione Peroxidase; D011505:Protein-Tyrosine Kinases; C062333:ROS1 protein, human; D002091:Butyrylcholinesterase; D000094765:Glutathione Peroxidase GPX1; C000722067:GPX1 protein, human