title: De novo complex chromosomal rearrangement of 46, XY, t (3; 16; 8) (p26; q13; q21.2) in a non-obstructive azoospermic male.
abstract: Complex Chromosomal Rearrangements (CCRs) are rare structural abnormalities that are usually associated with infertility or subfertility in male carriers. We described clinical and chromosomal features of a non-obstructive azoospermic male that has been referred for infertility. Cytogenetic analysis showed three chromosomes, i.e. 3, 8 and 16, which have been involved and caused spermatogenesis failure.
authors.affiliation: Department of Infertility Genetics, Infertility Clinic & Reproductive Biomedicine Research Center, Royan Institute, Tehran, Iran. salahshouri@gmail.com
authors.forename: Iman
authors.initials: I
authors.lastname: Salahshourifar
authors.forename: Mohammad Ali Sedighi
authors.initials: MA
authors.lastname: Gilani
authors.forename: Ahmad
authors.initials: A
authors.lastname: Vosough
authors.forename: Tayebeh
authors.initials: T
authors.lastname: Tavakolzadeh
authors.forename: Masoumeh
authors.initials: M
authors.lastname: Tahsili
authors.forename: Zahra
authors.initials: Z
authors.lastname: Mansori
authors.forename: Hamideh
authors.initials: H
authors.lastname: Karimi
authors.forename: Mehdi
authors.initials: M
authors.lastname: Totonchi
authors.forename: Hamid
authors.initials: H
authors.lastname: Gourabi
mesh_terms: D000328:Adult; D053713:Azoospermia / Q000235:genetics*; D002885:Chromosomes, Human, Pair 16 / Q000235:genetics*; D002893:Chromosomes, Human, Pair 3 / Q000235:genetics*; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics*; D006801:Humans; D007621:Karyotyping; D008297:Male; D013091:Spermatogenesis / Q000235:genetics; D014178:Translocation, Genetic