title: Synthesis of functionalized carboranes as potential anticancer and BNCT agents.
abstract: Carboranyl aldehydes react with alpha,beta-unsaturated esters, ketones, and nitriles in the presence of DABCO to provide functionalized carboranyl alcohols in good yields. Acetates of these alcohols undergo a facile isomerization with a variety of nucleophiles and afford structurally interesting carboranes. Biological evaluation of these molecules exhibited impressive antiproliferative activity for brain and breast cancer cells.
authors.affiliation: Department of Chemistry, University of Minnesota at Duluth, Chem 233, 1039 University Drive, Duluth, Minnesota 55812, USA.
authors.forename: Venkata Jaganmohan
authors.initials: VJ
authors.lastname: Reddy
authors.forename: Matthew M
authors.initials: MM
authors.lastname: Roforth
authors.forename: Chalet
authors.initials: C
authors.lastname: Tan
authors.forename: M Venkat Ram
authors.initials: MV
authors.lastname: Reddy
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D001896:Boron Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D016754:Boron Neutron Capture Therapy; D007536:Isomerism
chemical_list: D000970:Antineoplastic Agents; D001896:Boron Compounds