title: Primary resistance of human immunodeficiency virus type 1 in a reference center in Recife, Pernambuco, Brazil.
abstract: To assess the prevalence of primary resistance of human immunodeficiency virus type 1 (HIV-1) to antiretrovirals, 84 patients chronically infected with HIV without prior antiretroviral treatment from Northeast Brazil were studied. Genotyping was performed using the ViroSeq Genotyping System. Thimidine analog mutations occurred in 3 (3.6%) patients. Accessory mutations related to NRTI occurred in 6 (7.1%) and related to PI in 67 (79.8%). Subtypes B (72.6%), F (22.6%), B/F 3 (3.6%), and C (1.2%) were detected. A low prevalence of major mutations related to NRTI in patients chronically infected by HIV was observed.
authors.affiliation: Hospital das Clínicas, Departamento de Medicina Clínica, Universidade Federal de Pernambuco, Cidade Universitária, Recife, PE, Brasil.
authors.forename: Luzidalva Barbosa
authors.initials: LB
authors.lastname: de Medeiros
authors.forename: Heloísa Ramos
authors.initials: HR
authors.lastname: Lacerda
authors.forename: Ana Maria Salustiano
authors.initials: AM
authors.lastname: Cavalcanti
authors.forename: Maria de Fátima Pessoa Militão
authors.initials: Mde F
authors.lastname: de Albuquerque
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D001938:Brazil; D002908:Chronic Disease; D024882:Drug Resistance, Viral / Q000235:genetics*; D005260:Female; D005838:Genotype; D015658:HIV Infections / Q000188:drug therapy / Q000821:virology*; D016333:HIV Protease / Q000235:genetics; D054303:HIV Reverse Transcriptase / Q000235:genetics; D015497:HIV-1 / Q000187:drug effects* / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D016133:Polymerase Chain Reaction; D013936:Thymidine / Q000235:genetics
chemical_list: D019380:Anti-HIV Agents; D054303:HIV Reverse Transcriptase; D016333:HIV Protease; D013936:Thymidine