Electrophysiological studies of malaria parasite-infected erythrocytes: current status.
The altered permeability characteristics of erythrocytes infected with malaria parasites have been a source of interest for over 30 years. Recent electrophysiological studies have provided strong evidence that these changes reflect transmembrane transport through ion channels in the host erythrocyte plasma membrane. However, conflicting results and differing interpretations of the data have led to confusion in this field. In an effort to unravel these issues, the groups involved recently came together for a week of discussion and experimentation. In this article, the various models for altered transport are reviewed, together with the areas of consensus in the field and those that require a better understanding.
Staines
Henry M
HM
Centre for Infection, Division of Cellular and Molecular Medicine, St. George's, University of London, London SW17 0RE, UK. hstaines@sgul.ac.uk
Alkhalil
Abdulnaser
A
Allen
Richard J
RJ
De Jonge
Hugo R
HR
Derbyshire
Elvira
E
Egée
Stéphane
S
Ginsburg
Hagai
H
Hill
David A
DA
Huber
Stephan M
SM
Kirk
Kiaran
K
Lang
Florian
F
Lisk
Godfrey
G
Oteng
Eugene
E
Pillai
Ajay D
AD
Rayavara
Kempaiah
K
Rouhani
Sherin
S
Saliba
Kevin J
KJ
Shen
Crystal
C
Solomon
Tsione
T
Thomas
Serge L Y
SL
Verloo
Patrick
P
Desai
Sanjay A
SA
D000818:Animals; D000838:Anions / Q000378:metabolism; D002463:Cell Membrane Permeability / Q000187:drug effects / Q000502:physiology*; D003620:Dantrolene / Q000494:pharmacology; D004912:Erythrocytes / Q000469:parasitology* / Q000502:physiology; D005665:Furosemide / Q000494:pharmacology; D006801:Humans; D007473:Ion Channels / Q000503:physiopathology; D016778:Malaria, Falciparum / Q000469:parasitology* / Q000503:physiopathology; D049990:Membrane Transport Modulators / Q000494:pharmacology; D009579:Nitrobenzoates / Q000494:pharmacology; D010084:Oxidation-Reduction; D018408:Patch-Clamp Techniques; D010963:Plasmodium falciparum / Q000502:physiology
D000838:Anions; D007473:Ion Channels; D049990:Membrane Transport Modulators; D009579:Nitrobenzoates; C058176:5-nitro-2-(3-phenylpropylamino)benzoic acid; D005665:Furosemide; D003620:Dantrolene