title: Association of DAOA polymorphisms with schizophrenia and clinical symptoms or therapeutic effects.
abstract: The present study examined the correlation between variants in the d-amino acid oxidase activator (DAOA) locus and clinical symptoms and response to antipsychotics in schizophrenia. Case-control analysis and the family-based association test (FBAT) were performed to investigate whether four single nucleotide polymorphisms (SNPs) at DAOA gene are associated with schizophrenia. The association between the DAOA risk haplotype and clinical symptoms were examined by the positive and negative syndrome scale (PANSS) and the brief psychiatric rating scale (BPRS). Our findings showed that the SNP rs947267 was significantly associated with schizophrenia in both case control and familial trio samples (A>C, chi(2)=8.36, p=0.004; Z=2.335, p=0.019), as well as with specific haplotypes, in particular those formed by the A allele of rs947267. In addition, the risk haplotype AAG was significantly correlated with negative, depression and cognitive impairment factors of PANSS, even with the BPRS change scores after 6-week treatment of atypical antipsychotic drugs (p<0.05). These results support the hypothesis that variations in DAOA may play a role in schizophrenia and clinical characteristics.
authors.affiliation: Institute of Mental Health, Peking University, Beijing, China.
authors.forename: Weihua
authors.initials: W
authors.lastname: Yue
authors.forename: Guolian
authors.initials: G
authors.lastname: Kang
authors.forename: Yanbo
authors.initials: Y
authors.lastname: Zhang
authors.forename: Mei
authors.initials: M
authors.lastname: Qu
authors.forename: Fulei
authors.initials: F
authors.lastname: Tang
authors.forename: Yonghua
authors.initials: Y
authors.lastname: Han
authors.forename: Yan
authors.initials: Y
authors.lastname: Ruan
authors.forename: Tianlan
authors.initials: T
authors.lastname: Lu
authors.forename: Jifeng
authors.initials: J
authors.lastname: Zhang
authors.forename: Dai
authors.initials: D
authors.lastname: Zhang
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use; D002352:Carrier Proteins / Q000235:genetics*; D016022:Case-Control Studies; D004351:Drug Resistance / Q000235:genetics; D005190:Family; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000453:epidemiology; D006239:Haplotypes; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D008297:Male; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D012559:Schizophrenia / Q000188:drug therapy / Q000453:epidemiology / Q000235:genetics*
chemical_list: D014150:Antipsychotic Agents; D002352:Carrier Proteins; C475071:DAOA protein, human; D047908:Intracellular Signaling Peptides and Proteins