Acute sensory neuropathy associated with rabbit antithymocyte globulin.
Rabbit antithymocyte globulin (RATG) is indicated for the treatment of acute renal transplant rejection and has also been shown to be effective as an induction immunosuppressive agent after renal transplantation. We report a patient that developed a painful sensory neuropathy within an hour of receiving RATG. The neuropathic symptoms resolved within a month, and a careful review of his medications, exposures and comorbid conditions revealed no other causes of neuropathy. Since the administration of RATG and onset of symptoms were so closely related temporally and the symptoms resolved after the cessation of RATG, we believe it is likely this medication led to the development of neuropathy.
Cartwright
M S
MS
Department of Neurology, Wake Forest University School of Medicine, Winston-Salem, NC, USA. mcartwri@wfubmc.edu
Moore
P S
PS
Donofrio
P D
PD
Iskandar
S S
SS
Stratta
R J
RJ
D000328:Adult; D000818:Animals; D000961:Antilymphocyte Serum / Q000009:adverse effects* / Q000627:therapeutic use; D006084:Graft Rejection / Q000276:immunology / Q000517:prevention & control; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D016030:Kidney Transplantation / Q000276:immunology; D008297:Male; D009422:Nervous System Diseases / Q000139:chemically induced* / Q000503:physiopathology; D009475:Neurons, Afferent / Q000473:pathology* / Q000502:physiology; D011817:Rabbits; D014181:Transplantation Immunology / Q000276:immunology
D000961:Antilymphocyte Serum; D007166:Immunosuppressive Agents