[Surgical bladder wounds treated with Orbignya phalerata aqueous extract: controlled study in rats].
BACKGROUND
Wound healing is a complex process that deals with different biological and immunological systems and is essential to keep the organism integrity. Three well-defined phases occur: inflammatory, proliferative and maturation. A failure or lengthy phase may result in a delay or absence of it.


OBJECTIVE
The aim of this paper is to analyse comparatively the histological alteration provided by the use of the aqueous extract of Orbignya phalerata, in the healing process of bladder surgical wounds.


METHODS
Forty adult, male Wistar rats were used. The experimental procedure consisted of a longitudinal 2 cm long bladder incision and single layer interrupted suture of 5-0 polyglactine 910. Post-operatively, the rats were randomly divided into two groups of 20. The substance was not used in the control group. The Orbignya phalerata aqueous solution was used in the study group. The animals were observed and killed three and seven days later. Comparative histological analysis was accomplished between the groups.


RESULTS
Significant statistical differences were observed in the neo-formation variables (p= 0.001), chronic inflammation (p= 0.002) and fibroblastic proliferation (p= 0.023). Acute inflammation was very evident in the control group.


CONCLUSIONS
The time factor of wound healing showed homogeneity between experimental and control groups, however faster in the experimental one. The Orbignya phalerata had a favoring healing effect in the surgical incision on rats bladder.
Ferreira
Eduardo de Castro
Ede C
Universidade Federal do Maranhao.
Matias
Jorge Eduardo F
JE
Campos
Antonio Carlos L
AC
Tâmbara Filho
Renato
R
Rocha
Luiz Carlos de Almeida
LC
Timi
Jorge Rufino Ribas
JR
Sado
Heitor Naoki
HN
Sakamoto
Danielle Giacometti
DG
Tolazzi
André Ricardo D
AR
Soares Filho
Mario de Paula
Mde P
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D028023:Arecaceae / Q000737:chemistry*; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D007249:Inflammation / Q000188:drug therapy; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D013536:Suture Techniques; D001743:Urinary Bladder / Q000293:injuries / Q000473:pathology / Q000601:surgery*; D014945:Wound Healing / Q000187:drug effects*
D000893:Anti-Inflammatory Agents; D010936:Plant Extracts