title: Autonomic paraneoplastic neurological syndromes.
abstract: Autonomic paraneoplastic neurological syndromes (PNS) typically present as chronic gastrointestinal pseudo-obstruction or orthostatic hypotension and usually occur in association with other PNS rather than in isolation. Although rare, they are often debilitating, sometimes fatal, and probably seriously underdiagnosed. Here, we discuss the clinical, immunological and oncological features of these syndromes and review the molecular and cellular mechanism that may underlie the triggering and maintenance of their autoimmune pathogenesis.
authors.affiliation: Department of Neurology, Mellino Mellini Hospital, 25032 Chiari, Italy.
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Lorusso
authors.forename: Ian K
authors.initials: IK
authors.lastname: Hart
authors.forename: Daniela
authors.initials: D
authors.lastname: Ferrari
authors.forename: Gaelle K
authors.initials: GK
authors.lastname: Ngonga
authors.forename: Chiara
authors.initials: C
authors.lastname: Gasparetto
authors.forename: Giovanni
authors.initials: G
authors.lastname: Ricevuti
mesh_terms: D001323:Autoantibodies / Q000276:immunology*; D020274:Autoimmune Diseases of the Nervous System / Q000175:diagnosis* / Q000276:immunology* / Q000503:physiopathology / Q000628:therapy; D006801:Humans; D018448:Models, Immunological; D020361:Paraneoplastic Syndromes, Nervous System / Q000175:diagnosis* / Q000276:immunology* / Q000503:physiopathology / Q000628:therapy
chemical_list: D001323:Autoantibodies