[Relationship between bone metabolism and adipogenesis].
Clinically, fatty marrow, accumulation of adipocytes in bone marrow, is often observed in the patients who manifest bone diseases such as osteoporosis. Since adipocytes and osteoblasts are differentiated from mesenchymal stem cells, it would be clinically and biologically important to understand regulatory mechanisms of the balance between adipogenesis and osteoblastogenesis. Recently, experimental findings indicated the involvement of adipokines including leptin and adiponectin in bone metabolisms. Thus, adipocytes appear to play a role in regulation of bone metabolisms.
Nishimura
Riko
R
Osaka University Graduate School of Dentistry, Department of Molecular and Cellular Biochemistry.
Hata
Kenji
K
Yoneda
Toshiyuki
T
D017667:Adipocytes / Q000166:cytology* / Q000502:physiology; D050156:Adipogenesis; D052242:Adiponectin / Q000502:physiology; D000818:Animals; D001851:Bone Diseases, Metabolic / Q000378:metabolism*; D019485:Bone Morphogenetic Proteins / Q000502:physiology; D001842:Bone and Bones / Q000378:metabolism*; D002454:Cell Differentiation / Q000235:genetics / Q000502:physiology; D050659:Core Binding Factor Alpha 1 Subunit / Q000502:physiology; D006609:High Mobility Group Proteins / Q000502:physiology; D006801:Humans; D020738:Leptin / Q000502:physiology; D059630:Mesenchymal Stem Cells / Q000166:cytology; D010006:Osteoblasts / Q000166:cytology* / Q000502:physiology; D047495:PPAR gamma / Q000502:physiology; D055758:SOX9 Transcription Factor; D014157:Transcription Factors / Q000502:physiology
D052242:Adiponectin; D019485:Bone Morphogenetic Proteins; D050659:Core Binding Factor Alpha 1 Subunit; D006609:High Mobility Group Proteins; D020738:Leptin; D047495:PPAR gamma; D055758:SOX9 Transcription Factor; C527932:SOX9 protein, human; D014157:Transcription Factors