title: [Extraesophageal reflux in patients suffering from Zenker's diverticulum].
abstract: BACKGROUND
  Patients with Zenker's diverticulum often present with a hiatal hernia. Theoretically, the gastric acid fluid could rise up to the hypopharynx producing an injury to the mucosa of Killian's triangle and hypertrophy of the cricopharyngeal muscle. We performed dual-channel pH monitoring in healthy people as a control group and in patients with a Zenker's diverticulum to elucidate the relationship between Zenker's diverticulum and gastroesophageal reflux disease (GERD) as well as extraesophageal reflux (EER).
  
  
  METHODS
  Patients with Zenker's diverticulum underwent dual-channel 24-h pH monitoring to exclude the possibility of an EER or a GERD. The measurements were performed in 4 patients preoperatively and postoperatively as well as in 14 patients only postoperatively. The control group consisted of healthy volunteers who did not suffer from a reflux disease (n=20). In each group we determined the number of refluxes, the fraction time, the RAI (reflux area index), and the DeMeester Score Index. In addition we classified the severity of the EER with a grading system which was developed in an earlier study in our department.
  
  
  RESULTS
  Patients with a Zenker's diverticulum suffered significantly from EER (p<0.01). The difference between the patients measured preoperatively and the patients postoperatively was minor. More than 72% of the patients suffered from a severe EER.
  
  
  CONCLUSIONS
  Patients with a Zenker's diverticulum have a high possibility of suffering from EER and GERD. The pathophysiology of this relationship can only be speculated. In addition to a cricopharyngeal myotomy, long-term therapy with a PPI (proton pump inhibitor) seems indicated.
authors.affiliation: Klinik für Hals-Nasen-Ohrenheilkunde, Johannes-Gutenberg-Universität, Mainz, Germany. morales-divo@hno.klinik.uni-mainz.de
authors.forename: C
authors.initials: C
authors.lastname: Morales-Divo
authors.forename: P
authors.initials: P
authors.lastname: Jecker
authors.forename: B
authors.initials: B
authors.lastname: Lippert
authors.forename: W J
authors.initials: WJ
authors.lastname: Mann
mesh_terms: D005260:Female; D005764:Gastroesophageal Reflux / Q000175:diagnosis* / Q000209:etiology*; D006801:Humans; D008297:Male; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D012720:Severity of Illness Index; D016672:Zenker Diverticulum / Q000150:complications* / Q000175:diagnosis*