Implementation of dual simultaneous microelectrode recording systems during deep brain stimulation surgery for Parkinson's disease: technical note.
OBJECTIVE
Microelectrode recording during deep brain stimulation surgery improves the likelihood of successful target localization and enables the electrophysiological characterization of human neural structures. Many clinical recording systems do not support the ability to capture research-quality recordings. Established clinical centers already using such equipment may be prevented from acquiring human intracranial data because of the need to completely change recording systems to obtain research-quality recordings. This technical note describes the novel design and implementation of a recording system that significantly improves research capabilities without disrupting the existing clinical setup.


METHODS
This design introduces a second recording system (including pre-amplifier, differential amplifier, analog-to-digital converter, and computer with analysis software) that divides the microelectrode signal into two independent streams.


RESULTS
This design preserves the existing intraoperative recording setup, but significantly improves research-level recording, data storage, and analysis capabilities.


CONCLUSIONS
We provide the first description of such a system using components that are all commercially available and relatively inexpensive. This approach presents an appealing alternative to the purchase of an entirely new system for surgical teams that already perform intraoperative recordings to assist in stereotactic target localization, yet wish to expand their neurophysiological recording capabilities.
Moyer
Jason T
JT
Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Danish
Shabbar F
SF
Keating
Jeffrey G
JG
Finkel
Leif H
LH
Baltuch
Gordon H
GH
Jaggi
Jurg L
JL
D046690:Deep Brain Stimulation / Q000295:instrumentation* / Q000379:methods*; D006801:Humans; D008839:Microelectrodes; D010300:Parkinson Disease / Q000628:therapy*; D025321:Surgery, Computer-Assisted / Q000295:instrumentation* / Q000379:methods*