The prevalence of Candida albicans-associated diarrhoea in Buea, South West Cameroon.
A total of 362 stool specimens were collected from 184 and 178 patients presenting at the Buea district Hospital with and without diarrhoea, respectively. The samples were screened and cultured for Candida albicans using standard microbiological procedures. Of the 184 diarrhoeic stool cultures, 35.9% showed C. albicans overgrowth as indicated by count >or=10(4) CFL/mL. Of the 178 non diarrhoeic stool cultures, C. albicans was identified in 23.6% of samples and counts were all <10(4) CFU/mL. An association was observed for C. albicans overgrowth and diarrhoea (p<0.001). The majority of isolates (87.8%) from the 66 samples showing candida overgrowth were susceptible to Amphotericin B in anti-fungal drug sensitivity assays. Results of the study highly suggest that C. albicans is an important cause of diarrhoea in the study area. We recommend that this fungus should be routinely checked in individuals presenting with diarrhoea particularly children and patients on prolonged or frequent antibiotic therapy.
Nkuo-Akenji
Theresa K
TK
Department of Life Sciences, Faculty of Science, University of Buea, P.O. Box 63 Buea, S.W. Province, Cameroon.
Ndip
Roland N
RN
Ntoko
Fritz A
FA
D000293:Adolescent; D000328:Adult; D000368:Aged; D002163:Cameroon / Q000453:epidemiology; D002176:Candida albicans / Q000302:isolation & purification*; D002177:Candidiasis / Q000150:complications / Q000453:epidemiology*; D002648:Child; D002675:Child, Preschool; D003967:Diarrhea / Q000453:epidemiology / Q000382:microbiology*; D005243:Feces / Q000382:microbiology; D005260:Female; D006767:Hospitals, District; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D015995:Prevalence