title: Therapy-induced tumor immunosurveillance involves IFN-producing killer dendritic cells.
abstract: A unique class of IFN-producing killer dendritic cells (IKDC) resembling natural killer cells has been defined that can recognize and lyse tumor cells through a tumor necrosis factor-related apoptosis-inducing ligand-dependent mechanism. IKDC may mediate the host-dependent antitumor activity of Gleevec/STI571 and other therapeutics that can inhibit the c-kit tyrosine kinase. IKDC represent an important new component of the innate immune system responding to cancer.
authors.affiliation: Institut National de la Santé et de la Recherche Médicale U805, Faculté de Médecine Kremlin Bicêtre, Villejuif, France.
authors.forename: Evelyn
authors.initials: E
authors.lastname: Ullrich
authors.forename: Mathieu
authors.initials: M
authors.lastname: Bonmort
authors.forename: Grégoire
authors.initials: G
authors.lastname: Mignot
authors.forename: Nathalie
authors.initials: N
authors.lastname: Chaput
authors.forename: Julien
authors.initials: J
authors.lastname: Taieb
authors.forename: Cédric
authors.initials: C
authors.lastname: Ménard
authors.forename: Sophie
authors.initials: S
authors.lastname: Viaud
authors.forename: Thomas
authors.initials: T
authors.lastname: Tursz
authors.forename: Guido
authors.initials: G
authors.lastname: Kroemer
authors.forename: Laurence
authors.initials: L
authors.lastname: Zitvogel
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D001549:Benzamides; D003713:Dendritic Cells / Q000187:drug effects / Q000276:immunology*; D000068877:Imatinib Mesylate; D007167:Immunotherapy / Q000379:methods; D007371:Interferon-gamma / Q000096:biosynthesis / Q000276:immunology*; D051379:Mice; D009374:Neoplasms, Experimental / Q000276:immunology* / Q000628:therapy; D010879:Piperazines / Q000494:pharmacology; D011743:Pyrimidines / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D001549:Benzamides; D010879:Piperazines; D011743:Pyrimidines; D007371:Interferon-gamma; D000068877:Imatinib Mesylate