EEG-fMRI in children with pharmacoresistant focal epilepsy.
OBJECTIVE
To evaluate the usefulness of EEG-combined functional magnetic resonance imaging (EEG-fMRI) to localize epileptogenic sources.


METHODS
Six children (age 8-15 years) with lesional or nonlesional pharmacoresistant focal epilepsy were studied.


RESULTS
We found significant activations in four children, activation and deactivation in one child, and widespread deactivation in another. In four children, activations colocalized with the presumed location of the epileptic focus, one of which was confirmed by intracranial EEG.


CONCLUSIONS
EEG-fMRI is a promising tool to noninvasively localize epileptogenic regions in children with pharmacoresistant focal epilepsy.
De Tiège
Xavier
X
Neuroscience Unit, UCL Institute of Child Health, London, United Kingdom. xdetiege@ulb.ac.be
Laufs
Helmut
H
Boyd
Stewart G
SG
Harkness
William
W
Allen
Philip J
PJ
Clark
Chris A
CA
Connelly
Alan
A
Cross
J Helen
JH
D000293:Adolescent; D001931:Brain Mapping; D002648:Child; D004351:Drug Resistance; D004567:Electrodes, Implanted; D004569:Electroencephalography / Q000295:instrumentation / Q000379:methods*; D004828:Epilepsies, Partial / Q000175:diagnosis* / Q000601:surgery; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods*; D010100:Oxygen / Q000097:blood; D011300:Preoperative Care
D010100:Oxygen