title: Magnesium intake and colorectal cancer risk in the Netherlands Cohort Study.
abstract: Energy-adjusted magnesium intake was nonsignificantly inversely related to risk of colorectal cancer (n=2328) in the Netherlands Cohort Study on Diet and Cancer that started in 1986 (n=58 279 men and 62 573 women). Statistically significant inverse trends in risk were observed in overweight subjects for colon and proximal colon cancer across increasing quintiles of magnesium uptake (P-trend, 0.05 and 0.02, respectively). Although an overall protective effect was not afforded, our results suggest an effect of magnesium in overweight subjects, possibly through decreasing insulin resistance.
authors.affiliation: Department of Epidemiology, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands. PA.vandenBrandt@epid.unimass.nl
authors.forename: P A
authors.initials: PA
authors.lastname: van den Brandt
authors.forename: K M
authors.initials: KM
authors.lastname: Smits
authors.forename: R A
authors.initials: RA
authors.lastname: Goldbohm
authors.forename: M P
authors.initials: MP
authors.lastname: Weijenberg
mesh_terms: D000368:Aged; D015992:Body Mass Index; D015331:Cohort Studies; D015179:Colorectal Neoplasms / Q000517:prevention & control*; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D008274:Magnesium / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D009426:Netherlands
chemical_list: D008274:Magnesium