Effect of total enterectomy, pancreatectomy, and portal vein ligation on liver function and histology: a case report.
Impaired hepatic function and histology have been observed in experimental models of diversion of the portal vein blood inflow from the liver and among patients with intestinal failure. Survival after total enterectomy, pancreatectomy, and portal vein ligation, and the effect of such a condition on liver function have never been reported in humans. Herein a 32-year-old woman with familial adenomatous polyposis and multiple desmoid tumors involving the mesentery and the retroperitoneum underwent total enterectomy and pancreatectomy followed by en bloc transplantation of the stomach, small bowel, and pancreas. Due to early graft failure, the patient underwent graftectomy, ligation of the portal vein, and external drainage of the common bile duct. Liver function tests were checked daily and a liver biopsy performed 15 days after graftectomy. The patient died of a ruptured mycotic aneurysm of the abdominal aorta at 27 days after the graftectomy. Liver function tests remained normal throughout the postoperative period; liver biopsy showed normal hepatic architecture with mild portal inflammation and cholestasis and spotty necrosis. Total enterectomy with pancreatectomy and ligation of the portal vein are compatible with survival in humans (at least in the short term), allowing normal hepatic function with minimal histological alterations to the liver.
Vivarelli
M
M
Department of Surgery, University of Bologna, S Orsola Hospital, Bologna, Italy.
Lauro
A
A
Cucchetti
A
A
D'Errico
A
A
Pironi
L
L
Pinna
A D
AD
D000328:Adult; D004386:Duodenum / Q000601:surgery*; D005260:Female; D005736:Gardner Syndrome / Q000601:surgery*; D006801:Humans; D007421:Intestine, Small / Q000601:surgery*; D008099:Liver / Q000473:pathology; D010180:Pancreatectomy; D010289:Parenteral Nutrition, Total; D011183:Postoperative Complications / Q000601:surgery; D013156:Splenectomy; D013270:Stomach / Q000601:surgery*; D016896:Treatment Outcome; D014781:Viscera / Q000637:transplantation*