title: Factors related to diagnostic sensitivity using an ultrathin bronchoscope under CT guidance.
abstract: BACKGROUND
  We investigated factors related to the diagnostic sensitivity of CT-guided transbronchial biopsy (TBB) using an ultrathin bronchoscope and virtual bronchoscopy (VB) navigation for small peripheral pulmonary lesions.
  
  
  METHODS
  We have performed this procedure on 83 patients with 85 small peripheral pulmonary lesions (< 20 mm in diameter). We analyzed the relationship between the diagnostic sensitivity and the location of the lesions, the bronchial generation to which an ultrathin bronchoscope was inserted, and the lesion-bronchial and lesion-pulmonary arterial relationships on high-resolution CT.
  
  
  RESULTS
  Fifty-six of the 85 lesions (66%) were diagnosed following CT-guided TBB using an ultrathin bronchoscope with VB navigation. The lesions located in the left superior segment of the lower lobe (S6) had a significantly low diagnostic sensitivity compared to other locations (p < 0.01). When an ultrathin bronchoscope could be inserted to the fifth or greater bronchial generation, the yield was above the average diagnostic sensitivity of 66%. Moreover, not only the patients with the presence of a bronchus leading directly to a lesion (CT-bronchus sign), but also the patients with the presence of a pulmonary artery leading to a lesion (CT-artery sign), had high diagnostic sensitivity (p < 0.01). Multivariate analysis revealed that the location of lesion was an independent predictor of diagnostic sensitivity (p < 0.05).
  
  
  CONCLUSIONS
  The location of the lesion, the bronchial generation to which an ultrathin bronchoscope was inserted, and the presence of a bronchus as well as a pulmonary artery leading to the lesion were valuable for predicting successful CT-guided TBB using an ultrathin bronchoscope with VB navigation.
authors.affiliation: First Department of Medicine, Hokkaido University School of Medicine, North 15, West 7, Kitaku, Sapporo 060-8638, Japan.
authors.forename: Naofumi
authors.initials: N
authors.lastname: Shinagawa
authors.forename: Koichi
authors.initials: K
authors.lastname: Yamazaki
authors.forename: Yuya
authors.initials: Y
authors.lastname: Onodera
authors.forename: Hajime
authors.initials: H
authors.lastname: Asahina
authors.forename: Eiki
authors.initials: E
authors.lastname: Kikuchi
authors.forename: Fumihiro
authors.initials: F
authors.lastname: Asano
authors.forename: Kazuo
authors.initials: K
authors.lastname: Miyasaka
authors.forename: Masaharu
authors.initials: M
authors.lastname: Nishimura
mesh_terms: D001706:Biopsy / Q000295:instrumentation*; D020680:Bronchoscopes; D001999:Bronchoscopy; D004867:Equipment Design; D005260:Female; D006801:Humans; D008171:Lung Diseases / Q000000981:diagnostic imaging* / Q000473:pathology*; D008297:Male; D012680:Sensitivity and Specificity; D025321:Surgery, Computer-Assisted / Q000295:instrumentation*; D014057:Tomography, X-Ray Computed