title: Meningococcal disease associated with an acute post-streptococcal complement deficiency.
abstract: Chronic deficiencies in the complement pathway proteins are associated with an increased risk of meningococcal disease. Such deficiencies are caused by primary congenital immunodeficiency of a complement protein, properdin or mannose binding lectin, or are secondary to consumption of complement by systemic lupus erythematosus (SLE) or membranoproliferative glomerulonephritis (MPGN). Whatever the cause, the complement deficiency is always chronic. Here we report a case of meningococcal disease (MCD) in a child with a transient complement deficiency (CD), caused by post-streptococcal glomerulonephritis (PSGN).
authors.affiliation: Bristol Royal Hospital for Children, Bristol, UK.
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Daskas
authors.forename: Katie
authors.initials: K
authors.lastname: Farmer
authors.forename: Richard
authors.initials: R
authors.lastname: Coward
authors.forename: Michel
authors.initials: M
authors.lastname: Erlewyn-Lajeunesse
mesh_terms: D002648:Child; D003165:Complement System Proteins / Q000172:deficiency*; D005921:Glomerulonephritis / Q000209:etiology* / Q000473:pathology; D006417:Hematuria; D006801:Humans; D007668:Kidney / Q000473:pathology; D007958:Leukocyte Count; D008297:Male; D008589:Meningococcal Infections / Q000150:complications*; D008790:Metoprolol / Q000627:therapeutic use; D013290:Streptococcal Infections / Q000150:complications*
chemical_list: D003165:Complement System Proteins; D008790:Metoprolol