Total synthesis of (+)-sundiversifolide.
The first, enantiocontrolled total synthesis of (+)-sundiversifolide has been accomplished using the sequential ring-closing metathesis, [3,3]-sigmatropic rearrangement, and iodolactonization for the key assembly of the cis-fused oxabicyclo[5.3.0]decene framework of the natural product. [structure: see text]
Yokoe
Hiromasa
H
Graduate School of Pharmaceutical Sciences, The University of Tokushima, 1-78-1 Sho-machi, Tokushima 770-8505, Japan.
Sasaki
Hiroyuki
H
Yoshimura
Tomoyuki
T
Shindo
Mitsuru
M
Yoshida
Masahiro
M
Shishido
Kozo
K
D001688:Biological Products / Q000138:chemical synthesis*; D001643:Bridged Bicyclo Compounds / Q000737:chemistry; D001952:Bridged-Ring Compounds / Q000737:chemistry; D003500:Cyclization; D007783:Lactones / Q000737:chemistry; D008956:Models, Chemical; D013237:Stereoisomerism; D014966:Xanthenes / Q000138:chemical synthesis*
D001688:Biological Products; D001643:Bridged Bicyclo Compounds; D001952:Bridged-Ring Compounds; D007783:Lactones; D014966:Xanthenes; C516925:bicyclo(5.3.0)decane; C433844:sundiversifolide