Host vascular niche contributes to myocardial repair induced by intracoronary transplantation of bone marrow CD34+ progenitor cells in infarcted swine heart.
The effects of bone marrow cell transplantation (BMT) on myocardial infarct might be affected by host intrinsic circumferences. A best vascular niche was shown in the infarcted hearts with collateral vessels at 2 weeks after myocardial infarction (MI). BMT caused the greatest cardiac repairs after MI in the swine with better collateral vessels, which might be relative to richer collateral vessels, greater vessel densities, and higher expressions of basif fibroblast growth factor and stromal cell-derived factor-1 in the hearts before BMT. Our data suggest that existence of intrinsic collateral vessels contributes greatly to the beneficial effects of intracoronary BMT on cardiac repairs after MI. Disclosure of potential conflicts of interest is found at the end of this article.
Zhang
Shaoheng
S
Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, 180 Fen Lin Road, Shanghai 200032, China.
Ge
Junbo
J
Zhao
Lan
L
Qian
Juying
J
Huang
Zheyong
Z
Shen
Li
L
Sun
Aijun
A
Wang
Keqiang
K
Zou
Yunzeng
Y
D000818:Animals; D018952:Antigens, CD34 / Q000378:metabolism*; D016026:Bone Marrow Transplantation; D002452:Cell Count; D017023:Coronary Angiography; D003326:Coronary Circulation; D003331:Coronary Vessels / Q000503:physiopathology*; D016222:Fibroblast Growth Factor 2 / Q000235:genetics / Q000378:metabolism; D005786:Gene Expression Regulation; D006321:Heart / Q000503:physiopathology*; D006334:Heart Function Tests; D008297:Male; D009203:Myocardial Infarction / Q000139:chemically induced / Q000503:physiopathology / Q000628:therapy*; D018919:Neovascularization, Physiologic; D033581:Stem Cell Transplantation; D013318:Stroke Volume; D013552:Swine; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics / Q000378:metabolism; D014945:Wound Healing
D018952:Antigens, CD34; D042461:Vascular Endothelial Growth Factor A; D016222:Fibroblast Growth Factor 2