Antimicrobial activities of daptomycin, vancomycin, and oxacillin in human monocytes and of daptomycin in combination with gentamicin and/or rifampin in human monocytes and in broth against Staphylococcus aureus.
We investigated the antistaphylococcal activity of daptomycin, vancomycin, oxacillin, gentamicin, and rifampin in human monocyte-derived macrophages. Compared with vancomycin and oxacillin, daptomycin had the most rapid and greatest antibacterial activity, but that of oxacillin was most sustained. The combination of daptomycin, gentamicin, and rifampin was most effective intracellularly, while daptomycin plus gentamicin and the three-drug combination were most effective extracellularly, completely eliminating viable Staphylococcus aureus.
Baltch
Aldona L
AL
Infectious Disease Research Laboratory, Stratton VA Medical Center, and Albany Medical College, NY 12208, USA. aldona.baltch@med.va.gov
Ritz
William J
WJ
Bopp
Lawrence H
LH
Michelsen
Phyllis B
PB
Smith
Raymond P
RP
D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics / Q000494:pharmacology*; D017576:Daptomycin / Q000494:pharmacology; D004338:Drug Combinations; D005839:Gentamicins / Q000494:pharmacology; D006801:Humans; D008826:Microbial Sensitivity Tests; D009000:Monocytes / Q000187:drug effects* / Q000382:microbiology; D010068:Oxacillin / Q000494:pharmacology; D012293:Rifampin / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000254:growth & development; D014640:Vancomycin / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D004338:Drug Combinations; D005839:Gentamicins; D014640:Vancomycin; D017576:Daptomycin; D010068:Oxacillin; D012293:Rifampin