title: Structure of rat acidic fibroblast growth factor at 1.4 A resolution.
abstract: Fibroblast growth factors (FGFs) constitute a family of 22 structurally related heparin-binding polypeptides that are involved in the regulation of cell growth, survival, differentiation and migration. Here, a 1.4 A resolution X-ray structure of rat FGF1 is presented. Two molecules are present in the asymmetric unit of the crystal and they coordinate a total of five sulfate ions. The structures of human, bovine and newt FGF1 have been published previously. Human and rat FGF1 are found to have very similar structures.
authors.affiliation: Protein Laboratory, Institute of Molecular Pathology, Panum Institute, Blegdamsvej 3C, DK-2200 Copenhagen, Denmark. kulahin@plab.ku.dk
authors.forename: Nikolaj
authors.initials: N
authors.lastname: Kulahin
authors.forename: Vladislav
authors.initials: V
authors.lastname: Kiselyov
authors.forename: Arthur
authors.initials: A
authors.lastname: Kochoyan
authors.forename: Ole
authors.initials: O
authors.lastname: Kristensen
authors.forename: Jette Sandholm
authors.initials: JS
authors.lastname: Kastrup
authors.forename: Vladimir
authors.initials: V
authors.lastname: Berezin
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Bock
authors.forename: Michael
authors.initials: M
authors.lastname: Gajhede
mesh_terms: D000818:Animals; D002417:Cattle; D018360:Crystallography, X-Ray; D016220:Fibroblast Growth Factor 1 / Q000737:chemistry*; D006801:Humans; D008958:Models, Molecular; D011487:Protein Conformation; D051381:Rats; D013045:Species Specificity
chemical_list: D016220:Fibroblast Growth Factor 1