title: [Treatment of Graves-Basedow's disease with 131I. Assessment of a "modulated fixed activity" protocol].
abstract: OBJECTIVE
  The purpose of this study was to retrospectively evaluate the hypothyroidism rate, persistence of hyperthyroidism and the complications after the administration of 131I in 3 cohorts defined according to the activity of 131I administered.
  
  
  METHODS
  We consecutively treated 659 patients diagnosed with Graves-Basedow disease (GBD) with 131I. The activity was determined on the basis of a protocol that we called "modulated fixed activity". A total of 45 patients (Group 1) who had previously undergone surgery were given small 131I activities of between 111-185 MBq (3-5 mCi), 247 patients (Group 2) with normal or almost normal-sized thyroids were given activities of between 222-333 MBq (6-9 mCi) and the 367 patients with diffuse goiters (Group 3) activities of between 370-555 MBq (10-15 mCi).
  
  
  RESULTS
  A total of 69.2 % of the patients presented hypothyroidism at the end of the follow-up period. By groups, the percentages of hypothyroidism at the end of the follow-up period were 69 %, 68.8 % and 69.6 % respectively. The average time for the patients to present hypothyroidism was 2.7 years with a maximum de 12.3 years and a minimum of 2 months. No severe precocious complications after the administration of 131I were noted.
  
  
  CONCLUSIONS
  The choice of the modulated fixed doses of 131I for treatment of the GBD is a simple method and permit treatment in only one day.
authors.affiliation: Servicio de Medicina Nuclear, Hospital Clínico Universitario Lozano Blesa, Zaragoza, España. dolabos@unizar.es
authors.forename: D
authors.initials: D
authors.lastname: Abós
authors.forename: P
authors.initials: P
authors.lastname: Ruiz
authors.forename: E
authors.initials: E
authors.lastname: Prats
authors.forename: P
authors.initials: P
authors.lastname: Razola
authors.forename: F
authors.initials: F
authors.lastname: García
authors.forename: L
authors.initials: L
authors.lastname: Tardín
authors.forename: J
authors.initials: J
authors.lastname: Banzo
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002985:Clinical Protocols; D005260:Female; D006111:Graves Disease / Q000532:radiotherapy*; D006801:Humans; D007037:Hypothyroidism / Q000453:epidemiology / Q000209:etiology; D007457:Iodine Radioisotopes / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged
chemical_list: D007457:Iodine Radioisotopes