Cell-based biosensors for single cell monitoring and drug analysis.
Cell-based biosensors incorporate cells as sensing elements that convert a change in immediate environment to signals conducive for processing. It characterizes with high sensitivity, excellent selectivity and fast response. Cell-based biosensors have been implemented for a number of applications ranging from pharmaceutical screening to environmental pollutant detection. This work demonstrate a novel cell-based biosensor following the principle of light-addressable potentiometric sensor and field effect transistor for detecting the action potential of single living cell under drugs. The experimental results agree with our expectation.
Wang
Ping
P
Department of Biomedical Engineering, Zhejiang University, Hangzhou, China. cnpwang@mail.bme.zju.edu.cn
Xu
Gaixia
G
Qin
Lifeng
L
Xu
Ying
Y
Li
Yan
Y