Evidence for oxidative stress in the frontal cortex in patients with recurrent depressive disorder--a postmortem study.
Prefrontal cortical (PFC) and hippocampal (HI) volume reductions have been consistently found in patients with recurrent depressive disorder (DD). Here we examine the possibility that oxidative stress, widely implicated in neuronal cell damage, may contribute to these brain structural changes. We compared manganese (Mn) and copper/zinc (Cu/Zn) superoxide dismutase (SOD) coenzyme concentrations in postmortem PFC and hippocampal brain tissue from 7 patients with DD and 7 neuropsychiatrically healthy controls using sandwich-type enzyme-linked immunosorbent assay (ELISA) technique. The concentration of Cu/Zn-SOD was significantly increased in the PFC but not in the hippocampus of patients. There was no significant change in Mn-SOD enzyme concentration in either region. Our findings contribute to the growing body of evidence implicating oxidative stress in the pathophysiology of depressive disorder.
Michel
Tanja Maria
TM
Clinical Neurochemistry, Department Psychiatry and Psychotherapy, University Hospital Würzburg, Fürchsleinstr. 15, 97080 Würzburg, Germany. T.Michel@iop.kcl.ac.uk
Frangou
Sophia
S
Thiemeyer
Dorothea
D
Camara
Sibylle
S
Jecel
Julia
J
Nara
Keinosuke
K
Brunklaus
Andreas
A
Zoechling
Robert
R
Riederer
Peter
P
D000368:Aged; D000369:Aged, 80 and over; D003866:Depressive Disorder / Q000473:pathology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005625:Frontal Lobe / Q000473:pathology*; D006624:Hippocampus / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology*; D017397:Prefrontal Cortex / Q000473:pathology; D012008:Recurrence; D013482:Superoxide Dismutase / Q000378:metabolism
D013482:Superoxide Dismutase