title: Identification of tyrosinase inhibitors from Marrubium velutinum and Marrubium cylleneum.
abstract: Tyrosinase is a key enzyme in the production of melanins in plants and animals. Forty-five secondary metabolites isolated from Marrubium velutinum and Marrubium cylleneum belonging to the classes of flavonoids, phenylethanoid glycosides, phenolic acids and lignan glycosides were screened for their inhibitory activity against mushroom tyrosinase. Flavonoids and phenylethanoid glycosides showed moderate inhibitory activity, while phenolic acids were less active than phenylethanoid glycosides, suggesting that both phenolic groups are important for the activity.
authors.affiliation: Department of Pharmacognosy and Chemistry of Natural Products, School of Pharmacy, Panepistimiopolis-Zografou, Athens 15771, Greece.
authors.forename: Anastasia
authors.initials: A
authors.lastname: Karioti
authors.forename: Anastasia
authors.initials: A
authors.lastname: Protopappa
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Megoulas
authors.forename: Helen
authors.initials: H
authors.lastname: Skaltsa
mesh_terms: D000363:Agaricales / Q000201:enzymology; D002855:Chromatography, Thin Layer; D019327:Copper Sulfate / Q000737:chemistry; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D006115:Greece; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D027522:Marrubium / Q000737:chemistry*; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D013056:Spectrophotometry, Ultraviolet
chemical_list: D004791:Enzyme Inhibitors; D007202:Indicators and Reagents; D010936:Plant Extracts; D014442:Monophenol Monooxygenase; D019327:Copper Sulfate