Mood disorder in a patient with Smith-Magenis syndrome: a case report.
Smith-Magenis syndrome (SMS) is a microdeletion syndrome characterized by physical and neurobehavioural features. This report describes the case of a 27 year old female affected by SMS associated with a diagnosis, according to DSMIV criteria, of Mood Disorder N.O.S. and Intermittent Explosive Disorder. To our knowledge, the association of SMS with mood shifts has never been reported. Considering the genetic alterations that characterizes the SMS, further investigations on the region of the chromosome 17p11.2 could help produce more information on the role of melatonin in the genesis of mood disorder.
Bersani
Giuseppe
G
Department of Psychiatric Sciences and Psychological Medicine, "La Sapienza" University of Rome, Italy. giuseppe.bersani@uniroma1.it
Russo
Daniele
D
Limpido
Lucilla
L
Marconi
Daniela
D
D000328:Adult; D002886:Chromosomes, Human, Pair 17 / Q000235:genetics; D019465:Craniofacial Abnormalities / Q000235:genetics*; D005260:Female; D017353:Gene Deletion; D006801:Humans; D008607:Intellectual Disability / Q000235:genetics*; D008550:Melatonin / Q000502:physiology; D019964:Mood Disorders / Q000175:diagnosis* / Q000235:genetics*; D009123:Muscle Hypotonia / Q000235:genetics*; D013577:Syndrome
D008550:Melatonin