title: Response of risperidone treatment may be associated with polymorphisms of HTT gene in Chinese schizophrenia patients.
abstract: Serotonin transporter (5-HTT) is a key component of the serotonergic neurotransmitter system. Few studies have focused on polymorphisms of the serotonin transporter and antipsychotic response and, in particular, there have so far been no published studies on the association between the serotonin transporter and response to risperidone. This study examined the relationship between two polymorphisms of the serotonin transporter and the efficacy of risperidone treatment in 129 patients with schizophrenia. Our results revealed that patients with l allele of HTTRLP showed a greater improvement than those without l allele on the overall brief psychiatric rating scale (BPRS) (P=0.025). But no such relationship was found for the HTTVNTR. In haplotype analysis, the frequency of L-12 haplotype showed a significant difference between the responder group and the non-responder group (P=0.005). Our study has, for the first time, produced evidence that the potential for therapy in patients with schizophrenia is related to the HTTRLP polymorphism in the HTT gene and haplotype L-12 may help to predict risperidone treatment efficiency.
authors.affiliation: Bio-X center, Shanghai Jiao Tong University, Shanghai, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
authors.forename: Lan
authors.initials: L
authors.lastname: Yu
authors.forename: Guang
authors.initials: G
authors.lastname: He
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.forename: Ai-Ping
authors.initials: AP
authors.lastname: Zhang
authors.forename: Jing
authors.initials: J
authors.lastname: Du
authors.forename: Rui-Qi
authors.initials: RQ
authors.lastname: Tang
authors.forename: Xin-Zhi
authors.initials: XZ
authors.lastname: Zhao
authors.forename: Jie
authors.initials: J
authors.lastname: Ma
authors.forename: Jie-Kun
authors.initials: JK
authors.lastname: Xuan
authors.forename: Yue
authors.initials: Y
authors.lastname: Xiao
authors.forename: Niu-Fan
authors.initials: NF
authors.lastname: Gu
authors.forename: Guo-Ying
authors.initials: GY
authors.lastname: Feng
authors.forename: Ming-Qing
authors.initials: MQ
authors.lastname: Xu
authors.forename: Qing-He
authors.initials: QH
authors.lastname: Xing
authors.forename: Lin
authors.initials: L
authors.lastname: He
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000494:pharmacology; D001921:Brain / Q000187:drug effects / Q000378:metabolism / Q000503:physiopathology; D001923:Brain Chemistry / Q000235:genetics*; D002681:China; D004252:DNA Mutational Analysis; D004351:Drug Resistance / Q000235:genetics; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005820:Genetic Testing; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic / Q000235:genetics*; D018967:Risperidone / Q000494:pharmacology*; D012559:Schizophrenia / Q000188:drug therapy* / Q000235:genetics*; D012701:Serotonin / Q000378:metabolism; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*
chemical_list: D014150:Antipsychotic Agents; D005819:Genetic Markers; D050486:Serotonin Plasma Membrane Transport Proteins; D012701:Serotonin; D018967:Risperidone