title: Oxidative stress markers in surgically treated patients with refractory epilepsy.
abstract: OBJECTIVE
  This study examines the redox status of drug-resistant epileptic patients and how it is modified after surgical treatment.
  
  
  METHODS
  The activity of antioxidant enzymes (superoxide dismutase, catalase and glutathione peroxidase), and markers of damage to biomolecules (malondialdehyde and advanced oxidation protein products) were determined by spectrophotometric methods in the serum of 9 drug-resistant epileptic patients, before and at different times after surgery, and in 32 control subjects.
  
  
  RESULTS
  Pre-surgery, epileptic patients presented increases in markers of oxidative damage and alterations in the activities of antioxidant enzymes. Additionally, patients showed a correlation between advanced oxidation protein products and the evolution time of the illness. After surgery, patients showed a trend to normalization in all the measured variables, except for the superoxide dismutase activity.
  
  
  CONCLUSIONS
  Drug-resistant temporal lobe epilepsy is associated with an oxidative stress condition that is favourably modified by the surgical resection of the epileptic foci.
authors.affiliation: CIREN (International Center of Neurological Restoration), Ave 25 # 15805, 11300 Playa, Havana City, Cuba. erojas@infomed.sld.cu
authors.forename: Jeffrey
authors.initials: J
authors.lastname: López
authors.forename: María E
authors.initials: ME
authors.lastname: González
authors.forename: Lourdes
authors.initials: L
authors.lastname: Lorigados
authors.forename: Lilia
authors.initials: L
authors.lastname: Morales
authors.forename: Gretel
authors.initials: G
authors.lastname: Riverón
authors.forename: José Y
authors.initials: JY
authors.lastname: Bauzá
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000378:metabolism; D015415:Biomarkers / Q000097:blood*; D002374:Catalase / Q000097:blood; D004827:Epilepsy / Q000097:blood* / Q000601:surgery; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D018384:Oxidative Stress; D013482:Superoxide Dismutase / Q000097:blood
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D008315:Malondialdehyde; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase