Synthesis and biological evaluation of nucleoside dicarboxylates as potential mimics of nucleoside diphosphates.
A series of nucleotide analogues wherein the diphosphate moiety has been replaced by a dicarboxylate were synthesized and tested for inhibitory activity against nucleoside diphosphate (NDP) kinase as well as several pathogenic bacterial strains.
Boudreau
Marc A
MA
Department of Chemistry, Gunning/Lemieux Chemistry Centre, University of Alberta, Edmonton, Alberta T6G 2G2, Canada.
Vederas
John C
JC
D040761:Biomimetic Materials / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D003998:Dicarboxylic Acids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D011756:Diphosphates / Q000737:chemistry*; D004789:Enzyme Activation / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D008958:Models, Molecular; D015394:Molecular Structure; D009701:Nucleoside-Diphosphate Kinase / Q000037:antagonists & inhibitors; D009705:Nucleosides / Q000737:chemistry*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D003998:Dicarboxylic Acids; D011756:Diphosphates; D004791:Enzyme Inhibitors; D009705:Nucleosides; D009701:Nucleoside-Diphosphate Kinase