Division of labor by dendritic cells.
Dendritic cells induce the activation of CD8 and CD4 T cells by presenting antigenic peptides on MHC class I and class II molecules, respectively. In a recent Science paper, Dudziak et al. (2007) reveal that these tasks are handled by distinct populations of dendritic cells in vivo.
Iwasaki
Akiko
A
Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA. akiko.iwasaki@yale.edu
D000818:Animals; D017951:Antigen Presentation; D039481:CD11b Antigen / Q000276:immunology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D016827:CD8 Antigens / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D003713:Dendritic Cells / Q000166:cytology / Q000276:immunology*; D015395:Histocompatibility Antigens Class I / Q000276:immunology; D000949:Histocompatibility Antigens Class II / Q000276:immunology; D008213:Lymphocyte Activation; D051379:Mice
D039481:CD11b Antigen; D016827:CD8 Antigens; C409469:CD8 antigen, alpha chain; D015395:Histocompatibility Antigens Class I; D000949:Histocompatibility Antigens Class II