Comparative study of photodynamic therapy vs CO2 laser vaporization in treatment of condylomata acuminata: a randomized clinical trial.
BACKGROUND
Most conventional therapies for condylomata acuminata (CA) are traumatic and have high recurrence rates.


OBJECTIVE
To investigate the efficacy and safety of topical application of 5-aminolaevulinic acid (ALA) photodynamic therapy (PDT) for the treatment of CA.


METHODS
Sixty-five patients with CA were allocated into the treatment (ALA-PDT) group and treated with 20% ALA solution under occlusive dressing for 3 h followed by irradiation with the helium-neon laser at a dose of 100 J cm(-2) and a power of 100 mW. Another 21 CA patients were allocated into the control group and treated with the CO(2) laser. The treatment was to be repeated 1 week later if the lesion was not completely removed after the first treatment.


RESULTS
After one treatment, the complete removal rate was 95% in the ALA-PDT group and 100% in the control group. After two treatments with ALA-PDT, the complete removal rate in the treatment group was 100%. The recurrence rate for ALA-PDT group was 6.3% which was significantly lower than that in control group (19.1%, P < 0.05). Moreover, the proportion of patients with adverse effects in the ALA-PDT group (13.9%) was also significantly lower than that in control group (100%, P < 0.05). The side-effects in patients treated with ALA-PDT mainly included mild burning and/or stinging restricted to the illuminated area.


CONCLUSIONS
The present study shows that topical application of ALA-PDT is a simpler, more effective and safer therapy with a lower recurrence for treatment of CA compared with conventional CO(2) laser therapy.
Chen
K
K
Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China.
Chang
B Z
BZ
Ju
M
M
Zhang
X H
XH
Gu
H
H
D000293:Adolescent; D000328:Adult; D000622:Aminolevulinic Acid / Q000627:therapeutic use; D003218:Condylomata Acuminata / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D005260:Female; D005831:Genital Diseases, Female / Q000188:drug therapy / Q000601:surgery; D005832:Genital Diseases, Male / Q000188:drug therapy / Q000601:surgery; D006801:Humans; D053685:Laser Therapy / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D010778:Photochemotherapy / Q000009:adverse effects / Q000379:methods*; D017319:Photosensitizing Agents / Q000627:therapeutic use; D012008:Recurrence; D016896:Treatment Outcome; D014522:Urethral Diseases / Q000188:drug therapy / Q000473:pathology / Q000601:surgery
D017319:Photosensitizing Agents; D000622:Aminolevulinic Acid