title: In vivo noninvasive monitoring of cerebral blood with optoacoustic technique.
abstract: We present the results of blood oxygenation (oxyhemoglobin saturation) measurements using an optoacoustic system in vivo in the superior sagittal sinus of sheep. The system included a nanosecond Nd:YAG laser as a source of radiation and a specially designed optoacoustic probe for signal detection. The optoacoustic signal induced in the superior sagittal sinus by the nanosecond laser pulses correlated well with actual oxyhemoglobin saturation measured with CO-oximeter. We propose to use a two- or multi- wavelength optoacoustic system for noninvasive continuous monitoring of cerebral venous blood oxygenation. The spectra of effective attenuation coefficient were measured in the range 680-1300 nm for oxy- and deoxygenated whole blood and can be employed for calibration of the system.
authors.affiliation: Center for Biomedical Engineering, University of Texas, Galveston, TX 77555, USA.
authors.forename: Y
authors.initials: Y
authors.lastname: Petrov
authors.forename: D
authors.initials: D
authors.lastname: Prough
authors.forename: D
authors.initials: D
authors.lastname: Deyo
authors.forename: I
authors.initials: I
authors.lastname: Petrova
authors.forename: M
authors.initials: M
authors.lastname: Motamedi
authors.forename: R
authors.initials: R
authors.lastname: Esenaliev