title: Interictal EEG in temporal lobe epilepsy in childhood.
abstract: The authors clarified the value of interictal discharges and verified which extratemporal regions may also show epileptiform activity in temporal lobe epilepsy (TLE) in childhood. Thirty consecutive patients aged 3 to 18 years (mean age = 12.16 years; 16 male) with TLE associated with hippocampal atrophy were studied. Each patient had 1 to 15 interictal EEG recordings (mean: 5.6; total = 192 EEGs). Video-EEG monitoring was performed in 20 patients. All patients had MRI. The findings were compared with a control group of 53 consecutive TLE adult outpatients with hippocampal atrophy. Each adult patient underwent 3 to 21 routine EEGs (mean: 10.67; total = 566). Interictal EEGs of children with TLE showed extratemporal epileptiform discharges more frequently than EEGs of adults with TLE. Frontal, parietal, and occipital discharges were more frequently seen in children (P < 0.05). These results suggest a close interaction between temporal and other cerebral regions in children with epilepsy and provide further evidence of the existence of neural networks.
authors.affiliation: Department of Neurology, State University of Campinas (Unicamp), Campinas, São Paulo, Brazil.
authors.forename: Renata C
authors.initials: RC
authors.lastname: Franzon
authors.forename: Kette D
authors.initials: KD
authors.lastname: Valente
authors.forename: Maria Augusta
authors.initials: MA
authors.lastname: Montenegro
authors.forename: Sigride
authors.initials: S
authors.lastname: Thomé-Souza
authors.forename: Catarina A
authors.initials: CA
authors.lastname: Guimarães
authors.forename: Carlos A M
authors.initials: CA
authors.lastname: Guerreiro
authors.forename: Fernando
authors.initials: F
authors.lastname: Cendes
authors.forename: Marilisa M
authors.initials: MM
authors.lastname: Guerreiro
mesh_terms: D000293:Adolescent; D000328:Adult; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000503:physiopathology*; D002648:Child; D002675:Child, Preschool; D004569:Electroencephalography / Q000379:methods*; D004833:Epilepsy, Temporal Lobe / Q000175:diagnosis / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male