Transmission of drug-resistant tuberculosis among treated patients in Shanghai, China.
We sought to determine whether patients who had therapy failure with increasingly drug-resistant strains of tuberculosis had primary or acquired drug resistance, by genotyping the initial and subsequent drug-resistant clinical isolates of Mycobacterium tuberculosis collected from patients by the Shanghai Centers for Disease Control and Prevention over the course of a 5-year period. The vast majority of patients (27/32) had primary drug resistance, indicating transmission of a drug-resistant strain of M. tuberculosis. Only 16% (5/32) had acquired drug resistance because of a poor treatment regimen or nonadherence to an adequate regimen. Our findings highlight the urgency of increasing efforts to interrupt the transmission of drug-resistant tuberculosis in communities and facilities in Shanghai, China.
Li
Xia
X
Key Laboratory of Medical Molecular Virology, Shanghai Medical College, Shanghai, 200032, China.
Zhang
Ying
Y
Shen
Xin
X
Shen
Guomiao
G
Gui
Xiaohong
X
Sun
Bin
B
Mei
Jian
J
Deriemer
Kathryn
K
Small
Peter M
PM
Gao
Qian
Q
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000995:Antitubercular Agents / Q000494:pharmacology; D002681:China / Q000453:epidemiology; D024881:Drug Resistance, Bacterial; D005260:Female; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D009169:Mycobacterium tuberculosis / Q000145:classification / Q000187:drug effects / Q000302:isolation & purification*; D010349:Patient Compliance; D013183:Sputum / Q000382:microbiology; D014376:Tuberculosis / Q000188:drug therapy* / Q000453:epidemiology / Q000635:transmission*
D000995:Antitubercular Agents