Phenylacetate and benzoate clearance in a hyperammonemic infant on sequential hemodialysis and hemofiltration.
An infant with a suspected inborn metabolism error was treated with a metabolic cocktail of intravenous sodium phenylacetate (NaPh) and sodium benzoate (NaBz) for hyperammonemia. Sequential hemodialysis (HD) then hemofiltration (HF) was performed due to hyperammonemia. Dialytic and convective clearance (K; ml/min) of ammonia, NaPh, and NaBz was measured. The K of ammonia was 57 and 37 for HD and HF, respectively. The K of NaBz was 37 and 12 for HD and HF, respectively. The K of NaPh was 38 and 14 ml/min for HD and HF, respectively. Despite high clearance of both NaPh and NaBz by HD and HF, the hyperammonemia was corrected.
Bunchman
Timothy E
TE
Pediatric Nephrology, Dialysis and Transplantation, Helen DeVos Children's Hospital, Grand Rapids, MI, USA. timothy.bunchman@devoschildrens.org
Barletta
Gina-Marie
GM
Winters
John W
JW
Gardner
John J
JJ
Crumb
Teri L
TL
McBryde
Kevin D
KD
D000641:Ammonia / Q000097:blood / Q000493:pharmacokinetics; D006440:Hemofiltration; D006801:Humans; D022124:Hyperammonemia / Q000209:etiology* / Q000628:therapy*; D007231:Infant, Newborn; D010648:Phenylacetates / Q000009:adverse effects / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use; D006435:Renal Dialysis; D020160:Sodium Benzoate / Q000009:adverse effects / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use
D010648:Phenylacetates; D000641:Ammonia; C025136:phenylacetic acid; D020160:Sodium Benzoate