Prospective, declarative, and nondeclarative memory in young adults with spina bifida.
The consequences of congenital brain disorders for adult cognitive function are poorly understood. We studied different forms of memory in 29 young adults with spina bifida meningomyelocele (SBM), a common and severely disabling neural tube defect. Nondeclarative and semantic memory functions were intact. Working memory was intact with low maintenance and manipulation requirements, but impaired on tasks demanding high information maintenance or manipulation load. Prospective memory for intentions to be executed in the future was impaired. Immediate and delayed episodic memory were poor. Memory deficits were exacerbated by an increased number of lifetime shunt revisions, a marker for unstable hydrocephalus. Memory status was positively correlated with functional independence, an important component of quality of life.
Dennis
Maureen
M
Program in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, Canada. maureen.dennis@sickkids.ca
Jewell
Derryn
D
Drake
James
J
Misakyan
Talar
T
Spiegler
Brenda
B
Hetherington
Ross
R
Gentili
Fred
F
Barnes
Marcia
M
D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007360:Intelligence; D008297:Male; D008568:Memory / Q000145:classification / Q000502:physiology*; D008569:Memory Disorders / Q000209:etiology*; D009483:Neuropsychological Tests; D016135:Spinal Dysraphism / Q000503:physiopathology* / Q000523:psychology*