Body mass index does not predict prostate-specific antigen or percent free prostate-specific antigen in men undergoing prostate cancer screening.
OBJECTIVE
Body mass index (BMI) may alter serum prostate specific antigen (PSA) and percent free PSA (%fPSA) and may mask the risk of prostate cancer. We investigated the relationship between BMI and PSA or %fPSA.


METHODS
Height, weight, PSA and %fPSA were assessed in 616 consecutive screened men without prostate cancer. Continuously coded and categorised BMI was studied. Statistical analyses consisted of ANOVA, linear regression, bivariate and partial correlations.


RESULTS
Median age was 57 years. Median PSA was 1.0 and median %fPSA was 26. Median BMI was 25.8 kg/m(2). Neither continuously coded nor categorised BMI correlated with either PSA or %fPSA in unadjusted or age-adjusted analyses (all p values > or = 0.3).


CONCLUSIONS
Body mass index does not affect PSA or %fPSA in men without known prostate cancer, who undergo prostate cancer screening. Therefore, PSA or %fPSA-based screening or early detection efforts do not require an adjustment for BMI.
Hutterer
Georg
G
Cancer Prognostics and Health Outcomes Unit, University of Montreal Health Center, 1058, rue St-Denis, Montréal, Que, Canada.
Perrotte
Paul
P
Gallina
Andrea
A
Walz
Jochen
J
Jeldres
Claudio
C
Traumann
Miriam
M
Suardi
Nazareno
N
Saad
Fred
F
Bénard
François
F
Valiquette
Luc
L
McCormack
Michael
M
Graefen
Markus
M
Montorsi
Francesco
F
Karakiewicz
Pierre I
PI
D000328:Adult; D017677:Age Distribution; D000368:Aged; D000704:Analysis of Variance; D015992:Body Mass Index; D015331:Cohort Studies; D006801:Humans; D008297:Male; D008403:Mass Screening / Q000379:methods; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000150:complications; D050177:Overweight / Q000502:physiology; D017430:Prostate-Specific Antigen / Q000097:blood*; D011471:Prostatic Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000503:physiopathology; D012307:Risk Factors
D017430:Prostate-Specific Antigen