The rag locus of Porphyromonas gingivalis contributes to virulence in a murine model of soft tissue destruction.
The rag locus of Porphyromonas gingivalis encodes a putative TonB-dependent outer membrane receptor, RagA, and a 55-kDa immunodominant antigen, RagB. Inactivation of either ragA or ragB prevented expression of both RagA and RagB. Both the ragA and ragB mutants were significantly less virulent than wild-type strains in a murine model of infection.
Shi
Xiaoju
X
Centre for Infectious Disease, Institute of Cell and Molecular Science, Barts and The London School of Medicine and Dentistry, 4 Newark Street, London E1 2AT, United Kingdom.
Hanley
Shirley A
SA
Faray-Kele
Marie-Claire
MC
Fawell
Stuart C
SC
Aduse-Opoku
Joseph
J
Whiley
Robert A
RA
Curtis
Michael A
MA
Hall
Lucinda M C
LM
D000818:Animals; D001426:Bacterial Proteins / Q000235:genetics / Q000502:physiology*; D016866:Bacteroidaceae Infections / Q000382:microbiology*; D004195:Disease Models, Animal; D017353:Gene Deletion; D051379:Mice; D016966:Porphyromonas gingivalis / Q000235:genetics* / Q000472:pathogenicity*; D014774:Virulence / Q000235:genetics; D037521:Virulence Factors / Q000235:genetics / Q000502:physiology*
D001426:Bacterial Proteins; C484343:RagA protein, Porphyromonas gingivalis; C484346:RagB protein, bacteria; D037521:Virulence Factors