title: Testing conclusions from functional imaging of working memory with data from acute stroke.
abstract: Functional imaging studies indicate that the left hemisphere mediates verbal working memory, while the right hemisphere mediates both verbal and spatial working memory. We evaluated acute stroke patients with working memory tests and imaging to identify whether unilateral dysfunction causes deficits in spatial and/or verbal working memory deficits. While left cortical stroke patients had verbal working memory impairments (p<0.003), right cortical stroke patients had both verbal p<0.007) and spatial working memory (p<0.03) impairments, confirming functional imaging results. Patients with transient ischemic stroke and patients with non-cortical stroke did not have significant deficits in working memory in either modality.
authors.affiliation: Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. argye@JHMI.edu
authors.forename: Lisa E
authors.initials: LE
authors.lastname: Philipose
authors.forename: Hannah
authors.initials: H
authors.lastname: Alphs
authors.forename: Vivek
authors.initials: V
authors.lastname: Prabhakaran
authors.forename: Argye E
authors.initials: AE
authors.lastname: Hillis
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001931:Brain Mapping; D038524:Diffusion Magnetic Resonance Imaging; D004193:Discrimination Learning / Q000502:physiology; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D002546:Ischemic Attack, Transient / Q000150:complications / Q000503:physiopathology; D018810:Magnetic Resonance Angiography; D008279:Magnetic Resonance Imaging; D008569:Memory Disorders / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology; D008570:Memory, Short-Term / Q000502:physiology*; D008875:Middle Aged; D013028:Space Perception / Q000502:physiology; D020521:Stroke / Q000150:complications* / Q000503:physiopathology; D014706:Verbal Learning / Q000502:physiology