title: Innovative crystal transformation of dihydrate trehalose to anhydrous trehalose using ethanol.
abstract: The crystal transformation of dihydrate trehalose to anhydrous trehalose was investigated using ethanol and a new type of crystal particle with porous structure could be obtained. The specific surface area of the anhydrous crystal transformed at 50 degrees C was 3.3 m(2)/g, with a median pore diameter of 0.21 microm, and void volume of 0.22 mL/g. The crystal transformation was monitored by measuring the crystal moisture content. The crystal transformation rates could be correlated with the Avrami equation, using the mechanism parameter n=11.5, suggesting that the change of surface area occurred during crystal transformation from dehydrate to anhydrous trehalose. The apparent activation energy of the crystal transformation was 132 kJ/mol.
authors.affiliation: Department of Biotechnology, Tottori University, Koyama Minami 4-101, Tottori 680-8552, Japan.
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Ohashi
authors.forename: Hidefumi
authors.initials: H
authors.lastname: Yoshii
authors.forename: Takeshi
authors.initials: T
authors.lastname: Furuta
mesh_terms: D002152:Calorimetry, Differential Scanning; D003460:Crystallization; D000431:Ethanol / Q000737:chemistry*; D007700:Kinetics; D008855:Microscopy, Electron, Scanning; D044367:Phase Transition; D014199:Trehalose / Q000737:chemistry*; D014867:Water / Q000737:chemistry; D014961:X-Ray Diffraction
chemical_list: D014867:Water; D000431:Ethanol; D014199:Trehalose