Pharmacological studies on the sedative and hypnotic effect of salidroside from the Chinese medicinal plant Rhodiola sachalinensis.
This is the preliminary study of sedative and hypnotic activity of salidroside (a major component of Rhodiola sachalinensis) in mice by using synergism with pentobarbital as an index for the hypnotic effect. Loss of the righting reflex was used to determine the start of sleep. Sleep latency and sleeping time were evaluated in this experiment. The results showed that salidroside could obviously shorten the sleep latency and prolong the sleeping time of mice produced by pentobarbital sodium (55 mg/kg, i.p.). Salidroside produces significant sedative-hypnotic effect. The dose-effect relationship is remarkable.
Li
Tingli
T
Pharmaceutical College, Heilongjiang University of Chinese Medicine, Harbin, China. litingli8888@163.com
Xu
Guanghui
G
Wu
Lili
L
Sun
Chunyu
C
D000818:Animals; D004357:Drug Synergism; D005960:Glucosides / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D006993:Hypnotics and Sedatives / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010424:Pentobarbital / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D010636:Phenols / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D029771:Rhodiola; D012890:Sleep / Q000187:drug effects*
D005960:Glucosides; D006993:Hypnotics and Sedatives; D010636:Phenols; D010936:Plant Extracts; D010424:Pentobarbital; C009172:rhodioloside