title: Onset and underpinnings of white matter atrophy at the very early stage of multiple sclerosis--a two-year longitudinal MRI/MRSI study of corpus callosum.
abstract: BACKGROUND
  Atrophy of corpus callosum (CC), a white matter structure linking the two hemispheres, is commonly observed in multiple sclerosis (MS). However, the occurrence and processes leading to this alteration are not yet determined.
  
  
  OBJECTIVE
  To better characterize the onset and progression of CC atrophy from the early stage of MS, we performed a two-year follow-up magnetic resonance imaging/magnetic resonance spectroscopic imaging (MRI/MRSI) exploration of CC in 24 patients with clinically isolated syndrome. These patients were explored using the same protocol at month (M)6, M12 and M24. MRI/MRSI techniques were applied to measure CC volume, and relative concentrations of N-acetylaspartate (NAA), creatine/phosphocreatine (Cr) and choline-containing compounds (Cho). A group of matched controls was also explored.
  
  
  RESULTS
  Atrophy of CC, not present at baseline, was observed at M12 and progressed over the second year (M24). At baseline, a decrease in relative NAA level was observed in the anterior and posterior body of CC, with normalization during the follow-up period. In the anterior body, an increase in relative Cho level was observed, with normalization at M6. Normal relative Cr levels were observed at all time points in all sub-regions. The rate of CC atrophy was correlated with the change in the Expanded Disability Status Scale (EDSS) during the follow-up period.
  
  
  CONCLUSIONS
  These results suggest that CC atrophy appears over a period of one year after the first acute inflammatory episode, and that this atrophy is accompanied, especially in the anterior body of CC, by a normalization of the relative Cho levels, marker of acute inflammation, and NAA levels, marker of neuronal dysfunction and/or loss.
authors.affiliation: Centre de Résonance Magnétique Biologique et Médicale, UMR CNRS 6612, Faculté de Médecine, Université de la Méditerranée, 27 Boulevard Jean Moulin, Marseille 13385, 05, France.
authors.forename: B
authors.initials: B
authors.lastname: Audoin
authors.forename: D
authors.initials: D
authors.lastname: Ibarrola
authors.forename: I
authors.initials: I
authors.lastname: Malikova
authors.forename: E
authors.initials: E
authors.lastname: Soulier
authors.forename: S
authors.initials: S
authors.lastname: Confort-Gouny
authors.forename: M V Au
authors.initials: MV
authors.lastname: Duong
authors.forename: F
authors.initials: F
authors.lastname: Reuter
authors.forename: P
authors.initials: P
authors.lastname: Viout
authors.forename: A
authors.initials: A
authors.lastname: Ali-Chérif
authors.forename: P J
authors.initials: PJ
authors.lastname: Cozzone
authors.forename: J
authors.initials: J
authors.lastname: Pelletier
authors.forename: J P
authors.initials: JP
authors.lastname: Ranjeva
mesh_terms: D000328:Adult; D017668:Age of Onset; D001284:Atrophy; D003337:Corpus Callosum / Q000378:metabolism / Q000473:pathology*; D004185:Disability Evaluation; D018450:Disease Progression; D042241:Early Diagnosis; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D009103:Multiple Sclerosis / Q000378:metabolism / Q000473:pathology*; D009413:Nerve Fibers, Myelinated / Q000378:metabolism / Q000473:pathology*