Efficient h/d exchange reactions of alkyl-substituted benzene derivatives by means of the Pd/C-H(2)-D(2)O system.
A method for efficient and extensive H/D exchange of substituted benzene derivatives which is catalyzed by heterogeneous Pd/C in D(2)O as a deuterium source under hydrogen atmosphere is described. Multi-deuterium incorporation into unactivated linear or branched alkyl chains that bear a carboxyl, hydroxyl, ether, ester, or amide moiety and are connected with a benzene ring was achieved by using the Pd/C-H(2)-D(2)O system. The present method does not require expensive deuterium gas or any special equipment.
Esaki
Hiroyoshi
H
Laboratory of Medicinal Chemistry, Gifu Pharmaceutical University, Mitahora-higashi 5-6-1, Gifu 502-8585, Japan.
Aoki
Fumiyo
F
Umemura
Miho
M
Kato
Masatsugu
M
Maegawa
Tomohiro
T
Monguchi
Yasunari
Y
Sajiki
Hironao
H
D001555:Benzene Derivatives / Q000737:chemistry*; D017666:Deuterium Oxide / Q000737:chemistry*; D006859:Hydrogen / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D010165:Palladium / Q000737:chemistry*
D001555:Benzene Derivatives; D010165:Palladium; D006859:Hydrogen; D017666:Deuterium Oxide