title: Site-specific UBITh amyloid-beta vaccine for immunotherapy of Alzheimer's disease.
abstract: The UBITh AD immunotherapeutic vaccine for Alzheimer's disease uses an amyloid-beta (Abeta) immunogen having two designer peptides that have been engineered to elicit anti-N terminal Abeta(1-14) antibodies while minimizing potential for the generation of adverse anti-Abeta immune responses. The vaccine has been further designed for minimization of inflammatory reactivities through the use of a proprietary vaccine delivery system that biases Th2 type regulatory T cell responses in preference to Th1 pro-inflammatory T cell responses. In vitro studies and in vivo studies in small animals, baboons and macaques show that anti-Abeta antibodies are generated with the expected N-terminus site-specificity, and that these antibodies have functional immunogenicities to neutralize the toxic activity of Abeta and promote clearance of plaque deposition. The antibodies appear to draw Abeta from the CNS into peripheral circulation. Results indicate that the UBITh AD vaccine did not evoke anti-Abeta cellular responses in a transgenic mouse model for AD. The vaccine was safe and well tolerated in adult Cynomolgus macaques during a repeat dose acute and chronic toxicity study.
authors.affiliation: United Biomedical Inc., 25 Davids Drive, Hauppauge, NY 11788, USA. cywang@unitedbiomedical.com
authors.forename: Chang Yi
authors.initials: CY
authors.lastname: Wang
authors.forename: Connie L
authors.initials: CL
authors.lastname: Finstad
authors.forename: Alan M
authors.initials: AM
authors.lastname: Walfield
authors.forename: Charles
authors.initials: C
authors.lastname: Sia
authors.forename: Kenneth K
authors.initials: KK
authors.lastname: Sokoll
authors.forename: Tseng-Yuan
authors.initials: TY
authors.lastname: Chang
authors.forename: Xin De
authors.initials: XD
authors.lastname: Fang
authors.forename: Chung Ho
authors.initials: CH
authors.lastname: Hung
authors.forename: Birgit
authors.initials: B
authors.lastname: Hutter-Paier
authors.forename: Manfred
authors.initials: M
authors.lastname: Windisch
mesh_terms: D000544:Alzheimer Disease / Q000235:genetics / Q000276:immunology / Q000628:therapy*; D016229:Amyloid beta-Peptides / Q000008:administration & dosage* / Q000276:immunology; D000818:Animals; D000917:Antibody Formation; D000918:Antibody Specificity; D001921:Brain / Q000473:pathology; D004195:Disease Models, Animal; D015195:Drug Design; D004797:Enzyme-Linked Immunosorbent Assay; D006168:Guinea Pigs; D007167:Immunotherapy; D008251:Macaca; D051379:Mice; D008822:Mice, Transgenic; D010446:Peptide Fragments / Q000008:administration & dosage* / Q000737:chemistry / Q000276:immunology; D014612:Vaccines / Q000008:administration & dosage
chemical_list: D016229:Amyloid beta-Peptides; D010446:Peptide Fragments; D014612:Vaccines