title: Bioactive lignans from Peperomia heyneana.
abstract: Four new compounds, including three secolignans (1-3) and one tetrahydrofuran lignan (4), were isolated from the petroleum ether and EtOAc fractions of Peperomia heyneana. These compounds were accompanied by eight known secolignans, one known tetrahydrofuran lignan, one known cyclohexenone, and one known amide. The structures were elucidated mainly by 1D and 2D NMR and MS experiments, and the relative configurations by NOE techniques. Five compounds were evaluated for their inhibitory activities against HIV-1 in infected C8166 cells.
authors.affiliation: The National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, and the Graduate School, Chinese Academy of Sciences, 189 Guo Shou Jing Road, Zhangjiang Hi-Tech Park, Shanghai 201203, People's Republic of China.
authors.forename: Guo-Liang
authors.initials: GL
authors.lastname: Zhang
authors.forename: Na
authors.initials: N
authors.lastname: Li
authors.forename: Yun-Hua
authors.initials: YH
authors.lastname: Wang
authors.forename: Yong-Tang
authors.initials: YT
authors.lastname: Zheng
authors.forename: Zhen
authors.initials: Z
authors.lastname: Zhang
authors.forename: Ming-Wei
authors.initials: MW
authors.lastname: Wang
mesh_terms: D019380:Anti-HIV Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004365:Drugs, Chinese Herbal; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D015497:HIV-1 / Q000187:drug effects*; D006801:Humans; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D015394:Molecular Structure; D036941:Peperomia / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry*; D013601:T-Lymphocytes / Q000187:drug effects
chemical_list: D019380:Anti-HIV Agents; D004365:Drugs, Chinese Herbal; D005663:Furans; D017705:Lignans; C018674:tetrahydrofuran