Enantioselective synthesis of P-stereogenic benzophospholanes via palladium-catalyzed intramolecular cyclization.
Enantioselective or diastereoselective intramolecular cyclization of functionalized secondary phosphines or their borane adducts catalyzed by chiral Pd(diphosphine) complexes gave P-stereogenic benzophospholanes in up to 70% ee. These results provide a new method for the synthesis of chiral phospholanes, which are valuable ligands in asymmetric catalysis. [reaction: see text]
Brunker
Tim J
TJ
6128 Burke Laboratory, Department of Chemistry, Dartmouth College, Hanover, NH 03755, USA.
Anderson
Brian J
BJ
Blank
Natalia F
NF
Glueck
David S
DS
Rheingold
Arnold L
AL