title: Helicobacter heilmannii-associated gastritis: clinicopathologic findings and comparison with Helicobacter pylori-associated gastritis.
abstract: The aims of this study were to evaluate the clinicopathologic features of Helicobacter heilmannii-associated gastritis and to compare H. heilmannii-associated gastritis with H. pylori-associated gastritis. We reviewed 5,985 consecutive gastric biopsy specimens. All cases of chronic gastritis with Helicobacter infection were evaluated with the Updated Sydney System, and the grades of all gastritis variables were compared between H. heilmannii-associated gastritis and H. pylori-associated gastritis groups. There were 10 cases of H. heilmannii-associated gastritis (0.17%) and 3,285 cases of H. pylori-associated gastritis (54.9%). The organisms were superficially located within the mucous layer without adhesion to epithelial cells. Interestingly, in one case many intracytoplasmic H. heilmannii organisms were observed in parietal cells with cell damage. A case of low-grade mucosa-associated lymphoid tissue (MALT) lymphoma concomitant with H. heilmannii infection was detected. Compared to H. pylori-associated gastritis, H. heilmannii-associated gastritis showed less severe neutrophilic activity (p<0.0001), mononuclear cell infiltration (p=0.0029), and endoscopic findings of chronic gastritis devoid of erosion or ulcer (p=0.0309). In conclusion, we present the detailed clinicopathologic findings of H. heilmanniiassociated gastritis compared to H. pylori-associated gastritis. H. heilmannii-associated gastritis is uncommon and milder than H. pylori-associated gastritis, however it may be noteworthy with respect to the development of MALT lymphoma.
authors.affiliation: Department of Pathology, College of Medicine, Inje University Ilsanpaik Hospital, Goyang, Korea. meeah@hitel.net
authors.forename: Mee
authors.initials: M
authors.lastname: Joo
authors.forename: Ji Eun
authors.initials: JE
authors.lastname: Kwak
authors.forename: Sun Hee
authors.initials: SH
authors.lastname: Chang
authors.forename: Hanseong
authors.initials: H
authors.lastname: Kim
authors.forename: Je G
authors.initials: JG
authors.lastname: Chi
authors.forename: Kyung-Ah
authors.initials: KA
authors.lastname: Kim
authors.forename: Jeon Ho
authors.initials: JH
authors.lastname: Yang
authors.forename: June Sung
authors.initials: JS
authors.lastname: Lee
authors.forename: Young-Soo
authors.initials: YS
authors.lastname: Moon
authors.forename: Kyoung-Mee
authors.initials: KM
authors.lastname: Kim
mesh_terms: D000328:Adult; D005260:Female; D005756:Gastritis / Q000473:pathology*; D016481:Helicobacter Infections / Q000473:pathology*; D018247:Helicobacter heilmannii; D016480:Helicobacter pylori; D006801:Humans; D018442:Lymphoma, B-Cell, Marginal Zone / Q000209:etiology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000209:etiology / Q000473:pathology