title: Diagnosis and management of Wegener's granulomatosis in a dog.
abstract: A four-year-old maele/neutered mixed-breed dog was prsented for severe, multifocal, proliferative gingivitis. Histopathologic examination of incisional biopsies supported a diagnosis of Wegener's granulomatosis, an autoimmune vasculitis previously unreported in the veterinary literature. Diagnostic investigations for infectious, neoplastic, or other inflammatory conditions all provided negative results. Management with a combination of immunosuppressive agents resulted in complete resolution and remission of the presenting lesions and associated clinical signs.
authors.affiliation: Department of Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, 61802, USA. wvkrug@ncsu.edu
authors.forename: William
authors.initials: W
authors.lastname: Krug
authors.forename: Sandra Manfra
authors.initials: SM
authors.lastname: Marretta
authors.forename: Louis-Philippe
authors.initials: LP
authors.lastname: de Lorimier
authors.forename: Dean K
authors.initials: DK
authors.lastname: White
authors.forename: Luke
authors.initials: L
authors.lastname: Borst
mesh_terms: D000818:Animals; D003937:Diagnosis, Differential; D004283:Dog Diseases / Q000175:diagnosis* / Q000188:drug therapy*; D004285:Dogs; D005891:Gingivitis / Q000175:diagnosis / Q000188:drug therapy / Q000662:veterinary*; D014890:Granulomatosis with Polyangiitis / Q000175:diagnosis / Q000188:drug therapy / Q000662:veterinary*; D007150:Immunohistochemistry / Q000662:veterinary; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008297:Male; D016896:Treatment Outcome
chemical_list: D007166:Immunosuppressive Agents