title: Calculating the maximum recommended dose of local anesthetic.
abstract: Since patients have a wide variance in body size, it is appropriate to base the maximum recommended dose of a local anesthetic on a milligram of drug per kilogram of body weight. Other variables (severe overweight or underweight and cardiovascular compromise) also influence the appropriate maximum recommended dose. By calculating the specific dose limit from the maximum recommended dose for each patient, the chances of a local anesthetic overdose can be significantly reduced.
authors.affiliation: Section of Oral and Maxillofacial Surgery, Pathology and Anesthesiology, Department of Anesthesiology, College of Medicine and Public Health, The Ohio State University, Columbus 43218, USA.
authors.forename: Joel M
authors.initials: JM
authors.lastname: Weaver
mesh_terms: D000328:Adult; D000766:Anesthesia, Dental; D000779:Anesthetics, Local / Q000008:administration & dosage* / Q000506:poisoning; D001835:Body Weight; D002045:Bupivacaine / Q000008:administration & dosage; D002648:Child; D004347:Drug Interactions; D062787:Drug Overdose / Q000517:prevention & control; D004837:Epinephrine / Q000008:administration & dosage; D006801:Humans; D008012:Lidocaine / Q000008:administration & dosage; D008619:Mepivacaine / Q000008:administration & dosage; D013997:Time Factors; D014662:Vasoconstrictor Agents / Q000008:administration & dosage
chemical_list: D000779:Anesthetics, Local; D014662:Vasoconstrictor Agents; D008012:Lidocaine; D008619:Mepivacaine; D002045:Bupivacaine; D004837:Epinephrine