[Auto-antibodies against glutamic acid decarboxylase and diabetes].
The 1999 WHO classification delineates immune mediated type 1 diabetes from other types of diabetes by the presence of auto-antibodies against beta-cell constituents. The GAD65 auto-antibody test is the method of first choice because it has the highest sensitivity, specificity and positive predictive value and is the most standardized and well-characterized type 1 diabetes related auto-antibody analysis. It is recommended that demonstration of GAD auto-antibodies leads to diagnosis, classification or re-classification of diabetes patients as immune mediated type 1 diabetes.
Mandrup-Poulsen
Thomas R
TR
Steno Diabetes Center, Niels Steensens Vej 2, DK-2820 Gentofte. tmpo@steno.dk
D001323:Autoantibodies / Q000032:analysis*; D001324:Autoantigens / Q000032:analysis; D003657:Decision Making; D003922:Diabetes Mellitus, Type 1 / Q000145:classification / Q000175:diagnosis / Q000276:immunology*; D005968:Glutamate Decarboxylase / Q000276:immunology*; D006801:Humans; D050417:Insulin-Secreting Cells / Q000276:immunology; D011237:Predictive Value of Tests; D012307:Risk Factors; D012680:Sensitivity and Specificity
D001323:Autoantibodies; D001324:Autoantigens; D005968:Glutamate Decarboxylase