Free interleukin-2 receptors in children with trisomy 21 (Down's syndrome) and different levels of periodontal disease.
OBJECTIVE
To investigate levels of free interleukin-2 (IL-2) receptors in relation to differing levels of CIPD in children with trisomy 21 (Down's syndrome).


METHODS
Cross-sectional study of soluble IL-2 receptors in serum samples.


METHODS
Eighty children aged 10-13 years were included; 40 children with Down's syndrome and with varying levels of CIPD and 40 control children without Down's syndrome and without periodontitis. Serum samples were analysed using an enzyme-linked immunosorbent assay (ELISA) with two monoclonal antibodies.


RESULTS
In children with Down's syndrome and periodontitis, serum IL-2 receptor levels were significantly higher than in control subjects.
Cutando-Soriano
A
A
Department of Dentistry in Special Patients, School of Dentistry, University of Granada, Granada, Spain.
Gómez-Moreno
G
G
Bravo
M
M
D000293:Adolescent; D002648:Child; D002908:Chronic Disease; D003430:Cross-Sectional Studies; D004314:Down Syndrome / Q000097:blood* / Q000150:complications / Q000276:immunology; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000150:complications; D008297:Male; D010510:Periodontal Diseases / Q000097:blood* / Q000150:complications / Q000276:immunology; D015375:Receptors, Interleukin-2 / Q000097:blood*; D012016:Reference Values; D012720:Severity of Illness Index
D015375:Receptors, Interleukin-2