title: Virally mediated cervical cancer in the iatrogenically immunocompromised: applications for psychoneuroimmunology.
abstract: Oncogenic or high-risk (HR) human papillomavirus (HPV) infection is implicated in the pathogenesis of a number of cancers, including cervical cancer. HPV infected individuals who are immunocompromised secondary to acquired (e.g., human immunodeficiency virus [HIV]) or iatrogenic (e.g., systemic lupus erythematosus [SLE] patients and organ and hematopoeitic stem cell transplant recipients undergoing immunosuppressive therapy) immune deficiency are particularly at risk for HPV-initiated cervical neoplasia and cancer. Psychoneuroimmunologic (PNI) research has demonstrated that psychosocial factors such as stress, pessimism, and sleep quality may play a role in the promotion of HPV-mediated cervical neoplasia in HIV-positive women. However, no research to our knowledge has examined PNI mechanisms of HPV-mediated cervical neoplasia and cancer in women who are undergoing iatrogenic immunosuppressive therapy for the treatment of autoimmune disease or the prevention of graft-rejection. This article reviews the PNI mechanisms that may underlie the promotion of HPV-mediated cervical neoplasia and applies this model to HPV-infected women who are iatrogenically immunosuppressed, an understudied population at-risk for cervical cancer. Female transplant recipients, one such group, may provide a unique paradigm in which to explore further PNI mechanisms of HPV-mediated cervical neoplasia.
authors.affiliation: Department of Clinical and Health Psychology, College of Public Health and Health Professions, University of Florida, Gainesville, FL, USA.
authors.forename: Sally E
authors.initials: SE
authors.lastname: Jensen
authors.forename: Brandy
authors.initials: B
authors.lastname: Lehman
authors.forename: Michael H
authors.initials: MH
authors.lastname: Antoni
authors.forename: Deidre B
authors.initials: DB
authors.lastname: Pereira
mesh_terms: D052685:Alphapapillomavirus / Q000145:classification / Q000276:immunology* / Q000472:pathogenicity; D005260:Female; D006679:HIV Seropositivity / Q000276:immunology / Q000523:psychology; D006801:Humans; D016867:Immunocompromised Host / Q000276:immunology*; D007166:Immunosuppressive Agents / Q000276:immunology*; D011584:Psychology; D011598:Psychoneuroimmunology; D002583:Uterine Cervical Neoplasms / Q000276:immunology / Q000821:virology*
chemical_list: D007166:Immunosuppressive Agents