title: [Surgical bladder wounds treated with Orbignya phalerata aqueous extract: controlled study in rats].
abstract: BACKGROUND
  Wound healing is a complex process that deals with different biological and immunological systems and is essential to keep the organism integrity. Three well-defined phases occur: inflammatory, proliferative and maturation. A failure or lengthy phase may result in a delay or absence of it.
  
  
  OBJECTIVE
  The aim of this paper is to analyse comparatively the histological alteration provided by the use of the aqueous extract of Orbignya phalerata, in the healing process of bladder surgical wounds.
  
  
  METHODS
  Forty adult, male Wistar rats were used. The experimental procedure consisted of a longitudinal 2 cm long bladder incision and single layer interrupted suture of 5-0 polyglactine 910. Post-operatively, the rats were randomly divided into two groups of 20. The substance was not used in the control group. The Orbignya phalerata aqueous solution was used in the study group. The animals were observed and killed three and seven days later. Comparative histological analysis was accomplished between the groups.
  
  
  RESULTS
  Significant statistical differences were observed in the neo-formation variables (p= 0.001), chronic inflammation (p= 0.002) and fibroblastic proliferation (p= 0.023). Acute inflammation was very evident in the control group.
  
  
  CONCLUSIONS
  The time factor of wound healing showed homogeneity between experimental and control groups, however faster in the experimental one. The Orbignya phalerata had a favoring healing effect in the surgical incision on rats bladder.
authors.affiliation: Universidade Federal do Maranhao.
authors.forename: Eduardo de Castro
authors.initials: Ede C
authors.lastname: Ferreira
authors.forename: Jorge Eduardo F
authors.initials: JE
authors.lastname: Matias
authors.forename: Antonio Carlos L
authors.initials: AC
authors.lastname: Campos
authors.forename: Renato
authors.initials: R
authors.lastname: Tâmbara Filho
authors.forename: Luiz Carlos de Almeida
authors.initials: LC
authors.lastname: Rocha
authors.forename: Jorge Rufino Ribas
authors.initials: JR
authors.lastname: Timi
authors.forename: Heitor Naoki
authors.initials: HN
authors.lastname: Sado
authors.forename: Danielle Giacometti
authors.initials: DG
authors.lastname: Sakamoto
authors.forename: André Ricardo D
authors.initials: AR
authors.lastname: Tolazzi
authors.forename: Mario de Paula
authors.initials: Mde P
authors.lastname: Soares Filho
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D028023:Arecaceae / Q000737:chemistry*; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D007249:Inflammation / Q000188:drug therapy; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D013536:Suture Techniques; D001743:Urinary Bladder / Q000293:injuries / Q000473:pathology / Q000601:surgery*; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D000893:Anti-Inflammatory Agents; D010936:Plant Extracts