title: Correlation between serum ferritin levels and liver iron concentration determined by MR imaging: impact of hematologic disease and inflammation.
abstract: Liver iron concentration was determined in 28 patients by magnetic resonance imaging using the method of Gandon et al. (Non-invasive assessment of hepatic iron stores by MRI. Lancet 2004;363:357-362). The result showed a significant correlation with blood plasma ferritin content (Spearman's r=.66; P<.001) and a slightly improving correlation coefficient when limited to those patients not known to have inflammation (r=.82; n=17; P<.001). Zooming in on patients with hematologic disease also had a beneficial effect on the correlation between liver iron content and plasma ferritin level (r=.79; n=13; P=.001). It is concluded that in patients without inflammation and in patients with hematologic disease, the content of ferritin in blood is a better predictor of liver iron content than in other patient categories.
authors.affiliation: Department of Radiology, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands. a.w.olthof@rad.umcg.nl
authors.forename: Allard W
authors.initials: AW
authors.lastname: Olthof
authors.forename: Paul E
authors.initials: PE
authors.lastname: Sijens
authors.forename: Herman G
authors.initials: HG
authors.lastname: Kreeftenberg
authors.forename: Peter
authors.initials: P
authors.lastname: Kappert
authors.forename: Roy
authors.initials: R
authors.lastname: Irwan
authors.forename: Eric J
authors.initials: EJ
authors.lastname: van der Jagt
authors.forename: Matthijs
authors.initials: M
authors.lastname: Oudkerk
mesh_terms: D000465:Algorithms; D005260:Female; D005293:Ferritins / Q000097:blood*; D006801:Humans; D007501:Iron / Q000378:metabolism*; D008107:Liver Diseases / Q000378:metabolism*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged
chemical_list: D005293:Ferritins; D007501:Iron