title: 18FDG PET in hallucinating and non-hallucinating patients.
abstract: OBJECTIVE
  The aim of the study was to detect whether the abnormal regional brain activity correlates with auditory verbal hallucination-proneness (AVH) in a group of patients with schizophrenia and schizophrenia-related psychoses.
  
  
  METHODS
  15 patients with prominent AVH (score for hallucination intensity--item 3 in the PANSS > or =4) and 15 control patients without AVH (item 3 PANSS score < or =2) underwent 18FDG positron emission tomography at rest.
  
  
  RESULTS
  SPM group analysis revealed an increased uptake of 18FDG in the right middle frontal gyrus (BA46) in subjects with high verbal hallucination score compared to non-hallucinating patients (p<0.001, uncorrected). Activation in BA46 positively correlated with the intensity of hallucinations (Spearman r=0.57; p<0.001).
  
  
  CONCLUSIONS
  The observed functional recruitment of the right prefrontal cortex in subjects with high hallucination score may reflect impairment in the integration of intended actions and sensory feedback resulting in misattribution of internal events to an external source. This mechanism may form the cognitive basis for AVH.
authors.affiliation: Prague Psychiatric Centre, 3rd Medical Faculty Prague--Charles University, Centre of Neuropsychiatric Studies in Prague, Prague, Czech Republic. kopecek@pcp.lf3.cuni.cz
authors.forename: Miloslav
authors.initials: M
authors.lastname: Kopecek
authors.forename: Filip
authors.initials: F
authors.lastname: Spaniel
authors.forename: Tomás
authors.initials: T
authors.lastname: Novák
authors.forename: Barbora
authors.initials: B
authors.lastname: Tislerová
authors.forename: Otakar
authors.initials: O
authors.lastname: Belohlávek
authors.forename: Jirí
authors.initials: J
authors.lastname: Horácek
mesh_terms: D000328:Adult; D001931:Brain Mapping; D016022:Case-Control Studies; D003071:Cognition / Q000502:physiology; D005260:Female; D019788:Fluorodeoxyglucose F18; D006212:Hallucinations / Q000000981:diagnostic imaging* / Q000378:metabolism; D006801:Humans; D008297:Male; D049268:Positron-Emission Tomography; D017397:Prefrontal Cortex / Q000000981:diagnostic imaging* / Q000378:metabolism; D011618:Psychotic Disorders / Q000000981:diagnostic imaging / Q000378:metabolism; D019275:Radiopharmaceuticals; D012559:Schizophrenia / Q000000981:diagnostic imaging* / Q000378:metabolism
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18