Fleshing out filaggrin phenotypes.
The association of filaggrin null alleles with eczema has been replicated in several European populations. Three large, well-conducted studies confirm this association and offer insights into the phenotypic nature of eczema associated with these alleles. Early data suggest that FLG-associated eczema may be more persistent, more likely to have palmar hyperlinearity, and more likely to be associated with asthma. These initial hints will require further confirmation in cohort studies.
Irvine
Alan D
AD
Department of Pediatric Dermatology, Our Lady's Children's Hospital, Dublin, Ireland. irvinea@tcd.ie
D000483:Alleles; D001249:Asthma / Q000235:genetics*; D004485:Eczema / Q000175:diagnosis* / Q000235:genetics*; D000091344:Filaggrin Proteins; D020022:Genetic Predisposition to Disease; D006801:Humans; D007381:Intermediate Filament Proteins / Q000235:genetics* / Q000502:physiology*; D008957:Models, Genetic; D010641:Phenotype; D012107:Research Design; D012307:Risk Factors
C000717249:FLG protein, human; D000091344:Filaggrin Proteins; D007381:Intermediate Filament Proteins