title: On the origin of eukaryotic cells and their endomembranes.
abstract: A novel hypothesis for the origin of eukaryotic cells is presented. It is assumed that the universal ancestor was bounded by two membranes of heterochiral lipid composition. We propose that the prokaryotic cells (the hypothetical host entity for alpha proteic-bacteria), though sharing a common ancestor with Archaea, was bounded by two membranes. The hypothesis suggests that an alpha proteic-bacterial symbiont was enclosed in the prokaryotic cells intermembrane space. In this view, the eukaryotic nuclear membrane and endomembrane system arose from the prokaryotic cells inner membrane while the eukaryotic plasma membrane arose from the prokaryotic cells outer membrane. The outlined scenario agrees with the view that engulfment of an alpha-proteic-bacterial cell by a host entity and its transformation to a mitochondrion was the driving force leading to the appearance of the first eukaryotic cell. The hypothesis seems to be consistent with the pre-cell theory, theory of membrane heredity, and the phagocytosis-late scenario.
authors.affiliation: Institute of Cell Biology, Faculty of Natural Sciences, Comenius University, Mlynska dolina, 842 15 Bratislava, Slovakia. vesteg@fns.uniba.sk
authors.forename: Matej
authors.initials: M
authors.lastname: Vesteg
authors.forename: Juraj
authors.initials: J
authors.lastname: Krajcovic
authors.forename: Libor
authors.initials: L
authors.lastname: Ebringer
mesh_terms: D000818:Animals; D001105:Archaea; D001419:Bacteria; D005057:Eukaryotic Cells; D019143:Evolution, Molecular; D016678:Genome; D006801:Humans; D007425:Intracellular Membranes; D008928:Mitochondria; D008954:Models, Biological; D010587:Phagocytosis; D010802:Phylogeny; D010944:Plants; D011387:Prokaryotic Cells; D013559:Symbiosis