Major lymphocyte populations and T-cell expression of ICAM-1 and L-selectin adhesion molecules in Kuwaitis with asthma and rhinitis.
The authors evaluate major immunologic features of asthma and allergies in a Kuwaiti population. They analyzed peripheral venous blood from 17 asthmatic and 17 healthy long-term residents of Kuwait by using two-color flow cytometry for major lymphocyte subpopulations; they also evaluated 10 healthy individuals who had recently arrived in Kuwait. Relative to healthy subjects, asthmatics exhibited increased percentages of T+ NK cells (p < .01), T-helper cells (p < .05), T-cytotoxic and NK cells for both total numbers (p < .01-.001) and percentages (p < .05-.01), and increased percentages of T cells expressing CD54 (ICAM-1; p < .001) and CD62 (L-selectin; p < .01). However, B cells were present at significantly lower levels in asthmatics, both in total numbers (p < .05) and percentages (p < .01). In comparison with healthy individuals who had recently arrived in Kuwait, healthy long-term residents exhibited elevated numbers of pan-T cells (p < .01) and T-helper cells (p < .05). These results help establish immunological parameters for asthma and allergies in Kuwaiti populations.
Arifhodzic
Nermina A
NA
Al-Rashed Allergy Center, Sabah Hospital, Kuwait.
Mahmoud
Fadia F
FF
Abul
Habib T
HT
Haines
David D
DD
Al-Dowaisan
Abdel Rahman
AR
Ammar
Islam M
IM
Novotny
Ladislav
L
Wise
John A
JA
D000293:Adolescent; D000328:Adult; D001249:Asthma / Q000097:blood* / Q000150:complications / Q000276:immunology; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000096:biosynthesis*; D007730:Kuwait / Q000453:epidemiology; D019041:L-Selectin / Q000096:biosynthesis*; D018655:Lymphocyte Count; D008297:Male; D008875:Middle Aged; D006255:Rhinitis, Allergic, Seasonal / Q000097:blood* / Q000150:complications / Q000276:immunology; D016176:T-Lymphocyte Subsets / Q000378:metabolism; D013601:T-Lymphocytes / Q000378:metabolism*
D018799:Intercellular Adhesion Molecule-1; D019041:L-Selectin