Is the intrinsic disorder of proteins the cause of the scale-free architecture of protein-protein interaction networks?
In protein-protein interaction (PPI) networks certain topological properties appear to be recurrent: network maps are considered scale-free. It is possible that this topology is reflected in the protein structure. In this paper, we investigate the role of protein disorder in the network topology. We find that the disorder of a protein (or of its neighbors) is independent of its number of PPIs. This result suggests that protein disorder does not play a role in the scale-free architecture of protein networks.
Schnell
Santiago
S
Complex Systems Group, Indiana University School of Informatics, Bloomington, IN 47406, USA. schnell@indiana.edu
Fortunato
Santo
S
Roy
Sourav
S
D000818:Animals; D019277:Entropy; D006801:Humans; D025941:Protein Interaction Mapping; D011506:Proteins / Q000737:chemistry / Q000378:metabolism; D013223:Statistics as Topic
D011506:Proteins