PET kinetic analysis--compartmental model.
PET enables not only visualization of the distribution of radiotracer, but also has ability to quantify several biomedical functions. Compartmental model is a basic idea to analyze dynamic PET data. This review describes the principle of the compartmental model and categorizes the techniques and approaches for the compartmental model according to various aspects: model design, experimental design, invasiveness, and mathematical solution. We also discussed advanced applications of the compartmental analysis with PET.
Watabe
Hiroshi
H
Department of Investigative Radiology, National Cardiovascular Center Research Institute, 5-7-1 Fujishiro-dai, Suita, Osaka 565-8565, Japan. watabe@ri.ncvc.go.jp
Ikoma
Yoko
Y
Kimura
Yuichi
Y
Naganawa
Mika
M
Shidahara
Miho
M
D003198:Computer Simulation; D003627:Data Interpretation, Statistical; D019788:Fluorodeoxyglucose F18 / Q000493:pharmacokinetics*; D006801:Humans; D007700:Kinetics; D008279:Magnetic Resonance Imaging; D008962:Models, Theoretical; D009367:Neoplasm Staging; D049268:Positron-Emission Tomography / Q000295:instrumentation* / Q000379:methods*; D011868:Radioisotopes / Q000493:pharmacokinetics*; D013687:Telencephalon / Q000473:pathology; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods
D011868:Radioisotopes; D019788:Fluorodeoxyglucose F18