title: Sequence analysis and evolution of group B rotaviruses.
abstract: Human group B rotaviruses were isolated from hospitalized patients in Bangladesh between July 2003 and December 2004. Phylogenetic analyses of the gene segments encoding the hemagglutinin (VP4), glycoprotein (VP7) and RNA-binding protein (NSP2) of group B rotaviruses showed that Bangladeshi strains were more similar to the Indian strains than to the prototype Chinese strains. Moreover, all human strains were clustered together and were distantly related to the animal strains. With limited sequence data, the evolutionary rate of the glycoproteins (VP7) of human group B rotaviruses was estimated to be 1.57x10(-3) nucleotide substitutions/(siteyear), which was comparable to other rapidly evolving RNA viruses. The most recent common ancestor (MRCA) of the extant human group B rotaviruses was calculated to date to around 1976.
authors.affiliation: Laboratory of Virology, ICDDR,B, GPO Box-128, Dhaka 1000, Bangladesh. mustafizur.rahman@uz.kuleuven.ac.be
authors.forename: Mustafizur
authors.initials: M
authors.lastname: Rahman
authors.forename: Zahid M
authors.initials: ZM
authors.lastname: Hassan
authors.forename: Hasan
authors.initials: H
authors.lastname: Zafrul
authors.forename: Farjana
authors.initials: F
authors.lastname: Saiada
authors.forename: Sukalyani
authors.initials: S
authors.lastname: Banik
authors.forename: Abu S G
authors.initials: AS
authors.lastname: Faruque
authors.forename: Thomas
authors.initials: T
authors.lastname: Delbeke
authors.forename: Jelle
authors.initials: J
authors.lastname: Matthijnssens
authors.forename: Marc
authors.initials: M
authors.lastname: Van Ranst
authors.forename: Tasnim
authors.initials: T
authors.lastname: Azim
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000595:Amino Acid Sequence; D000956:Antigens, Viral / Q000737:chemistry / Q000235:genetics; D001483:Base Sequence; D036022:Capsid Proteins / Q000737:chemistry / Q000235:genetics; D002648:Child; D002675:Child, Preschool; D019143:Evolution, Molecular; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D010802:Phylogeny; D012401:Rotavirus / Q000145:classification* / Q000235:genetics
chemical_list: D000956:Antigens, Viral; D036022:Capsid Proteins; C050779:VP7 protein, Rotavirus