[Effects of baclofen on anxiety level, sexual motivation and olfactory perception in male mice with different psycho-emotional statuses].
Effects of GABA-B agonist baclofen (1, 2.5, 5 pg/kg, i. p.) on sexual and anxiety reactions and olfactory perception in C57Bl/6J male mice with different psychoemotional statuses (intact, aggressive, submissive) were studied. Baclofen increased time of finding olfactory bait. Baclofen's effects depend from psychoemotional statuses of animals. In intact males, baclofen carries anxiolytic effects and increase of sexual motivation; in submissive males, the drug does not influence on anxiety level, but prevents sexual interest from reduction; in aggressive males, baclofen increases anxiety level, but restores decreased sexual motivation.
Amikishieva
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Semendiaeva
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D000374:Aggression; D000818:Animals; D001007:Anxiety / Q000188:drug therapy*; D001418:Baclofen / Q000494:pharmacology*; D004644:Emotions; D005260:Female; D058786:GABA-B Receptor Agonists; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018080:Receptors, GABA-B / Q000502:physiology*; D012726:Sexual Behavior, Animal / Q000187:drug effects*; D012903:Smell / Q000187:drug effects*
D058786:GABA-B Receptor Agonists; D018080:Receptors, GABA-B; D001418:Baclofen