Higher nigrostriatal dopamine neuron loss in early than late onset Parkinson's disease?--a [99mTc]-TRODAT-1 SPECT study.
Early-onset Parkinson's disease (EOPD) is distinct from the classic late-onset PD (LOPD) because of its slower disease progression. The aim of this study was to compare dopamine neuronal loss in EOPD with that of LOPD with the same disease duration, through dopamine transporter (DAT) estimation. Fourteen patients, seven EOPD (<50 years) and seven LOPD, matched for disease duration were scanned with [(99m)Tc]-TRODAT-1-SPECT (INER-Taiwan), and were assessed with standard PD scales. EOPD patients had 34% lower striatal DAT binding potential (BP) compared with that of LOPD patients (BP = 0.29 +/- 0.12, BP = 0.44 +/- 0.12, P < 0.02) with similar PD severity. These results suggest that EOPD patients have greater dopamine density loss than LOPD patients without motor-symptom worsening.
Shih
Ming Chi
MC
Laboratório Interdiciplinar de Neuroimagem e Cognição (LiNC), Universidade Federal de São Paulo, Sao Paulo, Brazil. mingchi@psiquiatria.epm.br
Franco de Andrade
Luiz Augusto
LA
Amaro
Edson
E
Felicio
Andre Carvalho
AC
Ferraz
Henrique Ballalai
HB
Wagner
Jairo
J
Hoexter
Marcelo Queiroz
MQ
Lin
Li Fu
LF
Fu
Ying Kai
YK
Mari
Jair Jesus
JJ
Tufik
Sergio
S
Bressan
Rodrigo Affonseca
RA
D000328:Adult; D017668:Age of Onset; D000368:Aged; D003342:Corpus Striatum / Q000000981:diagnostic imaging*; D003863:Depression / Q000453:epidemiology; D004298:Dopamine / Q000032:analysis; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015609:Organotechnetium Compounds; D010300:Parkinson Disease / Q000000981:diagnostic imaging* / Q000523:psychology; D019275:Radiopharmaceuticals; D013378:Substantia Nigra / Q000000981:diagnostic imaging*; D015899:Tomography, Emission-Computed, Single-Photon; D014326:Tropanes
D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; D014326:Tropanes; C104196:technetium Tc 99m TRODAT-1; D004298:Dopamine