[Effect of 17beta-estradiol on content of cyclic nucleotides and protein kinases A and C activity in human adrenal cortex].
The influence of 17beta-estradiol on cAMP and cGMP levels, protein kinases A and C activityand corticosteroids secretion was investigated in postoperative human adrenal cortex tissue. cAMP accumulation in adrenocorticocytes increased uiider the influence of 17beta-estradiol. In vitro estradiol raised the activities of protein kinases A and C in membrane fraction of adrenal cortex tissue. Significant increasing of steroidogenesis was observed. These data support our conclusion that cAMP dependent siganling system is involved in activation of steroidogenesis by 17beta-estradiol.
Grinchenko
E N
EN
Kovzun
E I
EI
Mikosha
A S
AS
D015062:11-Hydroxycorticosteroids / Q000378:metabolism; D000302:Adrenal Cortex / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D000242:Cyclic AMP / Q000378:metabolism; D017868:Cyclic AMP-Dependent Protein Kinases / Q000378:metabolism*; D006152:Cyclic GMP / Q000378:metabolism; D004587:Electrophoresis, Agar Gel; D004958:Estradiol / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D008861:Microsomes / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D009712:Nucleotides, Cyclic / Q000378:metabolism*; D011493:Protein Kinase C / Q000378:metabolism*
D015062:11-Hydroxycorticosteroids; D009712:Nucleotides, Cyclic; D004958:Estradiol; D000242:Cyclic AMP; D017868:Cyclic AMP-Dependent Protein Kinases; D011493:Protein Kinase C; D006152:Cyclic GMP