Experimental study on ultrasonic thermal chemotherapy for tumor treatment.
Ultrasound Thermal Chemotherapy (UTC) method was used to investigate the mechanism of apoptosis of tumor cells induced by ultrasound thermal therapy combined with thermosensitive drug in Mice Tumor Model (MTM). And the optimal parameters of ultrasonic, such as frequency, dose, sound field, treatment time and temperature, were found by the animal trials which the Tca8113 cells had been inoculated into the body of nude mice. Experimental results showed that the optimized thermal treatment technology of ultrasonic combined with the chemotherapy could produce obvious inhibitory effects of the tumor's growth. We also found that apoptosis reached its highest levels in the 6thto 10thhour, then gradually decreased and nearly resumed the normal level after the 12thhour. UTC method could induce tumor cells to die significantly.
Bai
Jingfbai
J
Biomedical Instrument Institute, Shanghai Jiao Tong University, Shanghai, 200030, China.
Ren
Guoxin
G
Chen
Yazhu
Y
Guo
Wei
W