Raf kinase inhibitory protein knockout mice: expression in the brain and olfaction deficit.
Raf kinase inhibitory protein (RKIP-1) is involved in the regulation of the MAP kinase, NF-kappaB, and GPCR signaling pathways. It is expressed in numerous tissues and cell types and orthologues have been documented throughout the animal and plant kingdoms. RKIP-1 has also been reported as an inhibitor of serine proteases, and a precursor of a neurostimulatory peptide. RKIP-1 has been implicated as a suppressor of metastases in several human cancers. We generated a knockout strain of mice to further assess RKIP-1's function in mammals. RKIP-1 is expressed in many tissues with the highest protein levels detectable in testes and brain. In the brain, expression was ubiquitous in limbic formations, and homozygous mice developed olfaction deficits in the first year of life. We postulate that RKIP-1 may be a modulator of behavioral responses.
Theroux
Steven
S
Department of Natural Science, Assumption College, Worcester, MA, United States.
Pereira
Mandy
M
Casten
Kimberly S
KS
Burwell
Rebecca D
RD
Yeung
Kam C
KC
Sedivy
John M
JM
Klysik
Jan
J
D000818:Animals; D001921:Brain / Q000033:anatomy & histology / Q000254:growth & development / Q000378:metabolism*; D002460:Cell Line; D053595:Embryonic Stem Cells / Q000166:cytology / Q000378:metabolism; D005260:Female; D018507:Gene Expression Regulation, Developmental / Q000235:genetics*; D005808:Genes, Recessive / Q000235:genetics; D017930:Genes, Reporter / Q000235:genetics; D040582:Inheritance Patterns / Q000235:genetics; D008032:Limbic System / Q000033:anatomy & histology / Q000254:growth & development / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D009154:Mutation / Q000235:genetics; D000857:Olfaction Disorders / Q000235:genetics*; D009928:Organ Specificity; D049488:Phosphatidylethanolamine Binding Protein / Q000235:genetics*; D013737:Testis / Q000166:cytology / Q000254:growth & development / Q000378:metabolism*
D049488:Phosphatidylethanolamine Binding Protein