Molecular events that regulate alphabeta versus gammadelta T cell lineage commitment: old suspects, new players and different game plans.
The divergence of alphabeta and gammadelta T cells from a common precursor in the thymus is regulated by multiple cell-intrinsic and cell-extrinsic factors, most of which are not well defined. Recent studies have provided crucial data regarding the precise timing of lineage commitment and some clarification on the extent of the involvement of Notch and T-cell receptor signaling in this process. Combined with new insights into the differential regulation of molecular pathways active in alphabeta and gammadelta precursors, these data have led to the generation of a revised model of lineage commitment.
Narayan
Kavitha
K
University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA.
Kang
Joonsoo
J
D000818:Animals; D019070:Cell Lineage / Q000235:genetics; D038041:Lymphopoiesis / Q000235:genetics; D051379:Mice; D039902:Multipotent Stem Cells / Q000737:chemistry / Q000276:immunology*; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000032:analysis / Q000378:metabolism*; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000032:analysis / Q000378:metabolism*; D051880:Receptors, Notch / Q000502:physiology; D013601:T-Lymphocytes / Q000276:immunology*; D013950:Thymus Gland / Q000166:cytology / Q000276:immunology*
D016693:Receptors, Antigen, T-Cell, alpha-beta; D016692:Receptors, Antigen, T-Cell, gamma-delta; D051880:Receptors, Notch