Preventive effects of glycyrrhizin on estrogen-related endometrial carcinogenesis in mice.
We have previously reported on the inhibitory effect of Glycyrrhizae radix (Gl radix) on mouse endometrial carcinogenesis. The present study was performed to clarify the effects of Gl radix and glycyrrhizin (GL), the main part of Gl radix, on estradiol (E2)-related endometrial carcinogenesis. Both Gl radix and GL exerted a significant decrease in the COX-2, IL-1alpha and TNF-alpha mRNA expressions. GL generated a significant decrease in the incidence of endometrial adenocarcinoma. Accordingly, the preventive effects of Gl radix may be attributable to GL, thus being related with the suppression of COX-2, IL-1alpha and TNF-alpha. Gl radix and GL could therefore be a promising formula for the chemoprevention of human endometrial cancer.
Niwa
Kenji
K
Department of Obstetrics and Gynecology, Gifu University School of Medicine, Gifu 501-1194, Japan. kniwa@gifu-u.ac.jp
Lian
Zenglin
Z
Onogi
Kyoko
K
Yun
Wu
W
Tang
Liulin
L
Mori
Hideki
H
Tamaya
Teruhiko
T
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D051545:Cyclooxygenase 1 / Q000187:drug effects; D051546:Cyclooxygenase 2 / Q000187:drug effects; D016889:Endometrial Neoplasms / Q000378:metabolism / Q000517:prevention & control*; D004967:Estrogens / Q000378:metabolism; D005260:Female; D006035:Glycyrrhiza / Q000737:chemistry*; D019695:Glycyrrhizic Acid / Q000627:therapeutic use*; D007150:Immunohistochemistry; D053582:Interleukin-1alpha / Q000378:metabolism; D051379:Mice; D008813:Mice, Inbred ICR; D009376:Neoplasms, Hormone-Dependent / Q000517:prevention & control*; D010052:Ovariectomy; D010936:Plant Extracts / Q000627:therapeutic use*; D012333:RNA, Messenger / Q000187:drug effects; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014409:Tumor Necrosis Factor-alpha / Q000187:drug effects
D000970:Antineoplastic Agents; D004967:Estrogens; D053582:Interleukin-1alpha; D010936:Plant Extracts; D012333:RNA, Messenger; D014409:Tumor Necrosis Factor-alpha; D019695:Glycyrrhizic Acid; D051545:Cyclooxygenase 1; D051546:Cyclooxygenase 2