Associations among Epstein-Barr virus subtypes, human leukocyte antigen class I alleles, and the development of posttransplantation lymphoproliferative disorder in bone marrow transplant recipients.
The association between Epstein-Barr virus subtype, human leukocyte antigen class I alleles, and the development of posttransplantation lymphoproliferative disorder was examined in a group of 25 bone marrow transplant recipients. A highly statistically significant correlation was observed between the human leukocyte antigen B51 allele and development of posttransplantation lymphoproliferative disorder (P=.0016). This study provides, to our knowledge, the first evidence that the human leukocyte antigen B51 allele might predispose bone marrow transplant recipients to Epstein-Barr virus-associated posttransplantation lymphoproliferative disorder.
Görzer
Irene
I
Institute of Virology, Medical University of Vienna, Austria. irene.goerzer@meduniwien.ac.at
Puchhammer-Stöckl
Elisabeth
E
van Esser
Joost W J
JW
Niesters
Hubert G M
HG
Cornelissen
Jan J
JJ
D000483:Alleles; D016026:Bone Marrow Transplantation; D020031:Epstein-Barr Virus Infections / Q000209:etiology* / Q000235:genetics / Q000821:virology; D020022:Genetic Predisposition to Disease; D006680:HLA Antigens / Q000235:genetics*; D004854:Herpesvirus 4, Human / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D006801:Humans; D008232:Lymphoproliferative Disorders / Q000209:etiology* / Q000235:genetics / Q000821:virology; D014184:Transplantation, Homologous
D006680:HLA Antigens; D015395:Histocompatibility Antigens Class I