title: Optical diagnostic technology based on light scattering spectroscopy for early cancer detection.
abstract: This article reviews the application of optical diagnostic technology based on light scattering spectroscopy for minimally invasive detection of precancerous and early cancerous changes in a variety of organs. Optical spectroscopic techniques have shown promising results in the diagnosis of diseases at the cellular scale. They do not require tissue removal, can be performed in vivo and allow for real-time diagnosis. While fluorescence and Raman spectroscopy are most effective in revealing the molecular properties of tissue, the novel technique, light scattering spectroscopy, is capable of characterizing the structural properties of tissue at the cellular and subcellular scale.
authors.affiliation: Harvard University, Department of ObGyn and Reproductive Biology, Biomedical Imaging and Spectroscopy Laboratory, Beth Israel Deaconess Medical Center, Dana 879, Boston, MA 02215, USA. ltperel@bidmc.harvard.edu
authors.forename: Lev T
authors.initials: LT
authors.lastname: Perelman
mesh_terms: D042241:Early Diagnosis; D006801:Humans; D008027:Light; D009369:Neoplasms / Q000175:diagnosis*; D055095:Optics and Photonics; D011230:Precancerous Conditions / Q000175:diagnosis*; D012542:Scattering, Radiation; D013057:Spectrum Analysis / Q000379:methods*