Photodynamic efficacy of topical application of chlorin e6--polyvinyl pyrrolidone complex in tumor-bearing rats.
OBJECTIVE
To evaluate the antitumor efficacy of photodynamic therapy with ointment form of chlorin e6--polyvinyl pyrrolidone complex.


METHODS
2 or 5% chlorin e6 ointment was applied on the surface of rat SM-1 tumor for 15 min-5 h, and then tumors were scored for photosensitizer accumulation and tissue damage induced by laser irradiation.


RESULTS
Selectivity of chlorin e6 accumulation in tumor tissues considerably increases when photosensitizer was applied topically compared with intravenous administration. Antitumor efficacy of photodynamic therapy using topical application of chlorin e6--polyvinyl pyrrolidone complex is just as high as upon intravenous administration of the preparation.


CONCLUSIONS
The level of tissue accumulation of chlorin e6--polyvinyl pyrrolidone complex administered in ointment form allows to carry out fluorescence diagnosis and PDT of superficially localized malignant tumors.
Istoin
Y P
YP
N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Ministry of Health, Minsk, Belarus. istomin06@mail.ru
Laptsevich
T P
TP
Bizyuk
S A
SA
Alexandrova
E N
EN
D000287:Administration, Topical; D000818:Animals; D002735:Chlorophyllides; D009374:Neoplasms, Experimental / Q000188:drug therapy*; D009824:Ointments; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000008:administration & dosage*; D011166:Porphyrins / Q000008:administration & dosage*; D011205:Povidone / Q000008:administration & dosage*; D051381:Rats
D002735:Chlorophyllides; D009824:Ointments; D017319:Photosensitizing Agents; D011166:Porphyrins; C062985:phytochlorin; D011205:Povidone