title: Functional site analysis in proteins of g protein signaling pathways using fuzzy evolutionary trace method.
abstract: GPCRs are physiologically significant receptors linked to numerous diseases including cardiovascular disease, mental illness, and cancer. Inhibiting the interaction between a GPCR and its G-protein blocks the ability of the receptor to initiate a signal in a cell. G Protein active sites control nearly all G protein functions and determine the interactions upon which G protein signaling pathways are built. Characterization of the active sites in G protein or GPCRs would therefore lead to new methods of controlling G proteins and ultimately controlling cells. This paper use fuzzy evolutionary trace method to analyze the binding sites of G Protein and finally give an example.
authors.affiliation: Department of Bioinformatics, Capital University of Medical Sciences.
authors.forename: Zhang
authors.initials: Z
authors.lastname: Fan
authors.forename: Liu
authors.initials: L
authors.lastname: Zhicheng
authors.forename: Li
authors.initials: L
authors.lastname: Xia
authors.forename: Gao
authors.initials: G
authors.lastname: Zhiwen
authors.forename: Su
authors.initials: S
authors.lastname: Xuan