Polymorphisms of catechol-0-methyltransferase (COMT), monoamine oxidase B (MAOB), N-acetyltransferase 2 (NAT2) and cytochrome P450 2D6 (CYP2D6) gene in patients with early onset of Parkinson's disease.
The aim of the present study was to evaluate the contribution of MAOB, COMT, NAT2 and CYP2D6 gene polymorphisms to early onset Parkinson's disease (PD). The study enrolled 134 patients with Parkinson's disease (early onset-EOPD--67 patients, and late onset--LOPD--patients), and 66 healthy individuals. Polymerane chain reaction restriction fragment length polymorphism (PCR-RFLP) methods were used for genotyping. Univariate analysis revealed a significant two-fold higher EOPD risk among carriers of MAOB allele A or AA genotype. Multivariate analysis revealed that MAOB allele A was an independent factor predisposing to EOPD. It was shown that neither NAT2, CYP2D6 nor COMT genotype was associated with PD.
Bialecka
M
M
Departments of Experimental and Clinical Pharmacology, Pomeranian Medical University, Szczecin, Poland.
Klodowska-Duda
G
G
Honczarenko
K
K
Gawrońska-Szklarz
B
B
Opala
G
G
Safranow
K
K
Droździk
M
M
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D000544:Alzheimer Disease / Q000235:genetics*; D001191:Arylamine N-Acetyltransferase / Q000235:genetics*; D002394:Catechol O-Methyltransferase / Q000235:genetics*; D019389:Cytochrome P-450 CYP2D6 / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D008995:Monoamine Oxidase / Q000235:genetics*; D015999:Multivariate Analysis; D011110:Polymorphism, Genetic / Q000235:genetics*
D019389:Cytochrome P-450 CYP2D6; D008995:Monoamine Oxidase; D002394:Catechol O-Methyltransferase; D001191:Arylamine N-Acetyltransferase; C478900:NAT2 protein, human