[Advances of study on human translesion synthesis DNA polymerase eta].
Translesion synthesis(TLS) is a mechanism of DNA damage tolerance in cells,which can be divided into two categories: error-free TLS and error-prone TLS. Human polymerase eta( Pol eta) is one of translesion synthesis DNA polymerases. This protein exhibits lower fidelity and processivity than replicative DNA polymerases. In addition, it possesses "action-at-a-distance" and reverse transcriptase activity. Human Pol eta has the ability to catalyze error-free TLS and error-prone TSL, and may be involved in somatic hypermutation of immunoglobulin variable genes.
Hu
Gong-hua
GH
Department of Preventive Medicice, School of Public Heath, Sun Yat-sen University, Guangzhou 510080, China.
Zhuang
Zhi-xiong
ZX
D004249:DNA Damage; D004260:DNA Repair / Q000502:physiology*; D004259:DNA-Directed DNA Polymerase / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D006801:Humans; D009154:Mutation; D000099270:Y-Family DNA Polymerases
D004259:DNA-Directed DNA Polymerase; C112338:Rad30 protein; D000099270:Y-Family DNA Polymerases