title: [The assessment of urinary nicotine metabolites concentration in children and teenagers with oesophagitis].
abstract: Tobacco smoke is important pathogenetic agent of stomach digestive and duodenum ulcers, oesophagitis as well as gastro-oesophageal reflux disease. The aim of work was the assessment of urinary nicotine metabolites concentration in children and teenagers diagnosed and treated in Paediatrics Chair of Medical University of Silesia by chronic stomach pains, or oesophagitis and gastrooesophageal reflux disease symptoms. Urine was sampled from 54 persons before gastrofiberoscopy, in which the main nicotine metabolites concentration was determined by ELISA method and given per creatinine concentration. It was shown, that 30% of examined population was intensively exposed to tobacco smoke (actively or passively smoking), but 37% passively exposed to nicotine. Significant higher nicotine metabolites concentration was stated in the currently H. pylori infected sick, however without differences of these biomarkers concentrations between group with oesophagis in endoscopy as well as histopathologic examination and group without these features.
authors.affiliation: Katedra i Zakład Chemii Slaskiej, Akademii Medycznej w Katowicach. twielkoszynski@slam.katowice.pl
authors.forename: Tomasz
authors.initials: T
authors.lastname: Wielkoszyński
authors.forename: Barbara
authors.initials: B
authors.lastname: Kalita
authors.forename: Michał
authors.initials: M
authors.lastname: Paluch
authors.forename: Mariusz
authors.initials: M
authors.lastname: Opara
authors.forename: Marek
authors.initials: M
authors.lastname: Pluszczyk
authors.forename: Anna
authors.initials: A
authors.lastname: Obuchowicz
authors.forename: Marcin
authors.initials: M
authors.lastname: Wilczyński
authors.forename: Marta
authors.initials: M
authors.lastname: Slimok
authors.forename: Alicja
authors.initials: A
authors.lastname: Sikora
mesh_terms: D000293:Adolescent; D015415:Biomarkers / Q000097:blood / Q000652:urine; D002648:Child; D015897:Comorbidity; D003367:Cotinine / Q000097:blood / Q000652:urine*; D004784:Environmental Monitoring; D062665:Epidemiological Monitoring; D004941:Esophagitis / Q000097:blood / Q000453:epidemiology / Q000652:urine*; D005764:Gastroesophageal Reflux / Q000097:blood / Q000453:epidemiology / Q000652:urine; D016481:Helicobacter Infections / Q000097:blood / Q000453:epidemiology / Q000652:urine*; D006801:Humans; D009538:Nicotine / Q000097:blood / Q000652:urine*; D011044:Poland / Q000453:epidemiology; D012907:Smoking / Q000097:blood / Q000453:epidemiology / Q000652:urine*; D014028:Tobacco Smoke Pollution / Q000032:analysis*
chemical_list: D015415:Biomarkers; D014028:Tobacco Smoke Pollution; D009538:Nicotine; D003367:Cotinine