Hypoglycemic effects of a sesquiterpene glycoside isolated from leaves of loquat (Eriobotrya japonica (Thunb.) Lindl.).
Sesquiterpene glycoside, nerolidol-3-O-alpha-l-rhamnopyranosyl(1-->4)-alpha-l-rhamnopyranosyl(1-->2)-[alpha-l-rhamnopyranosyl(1-->6)]-beta-d-glucopyranoside was isolated from dried leaves of loquat [Eriobotrya japonica (Thunb.) Lindl., Rosaceae]. Hypoglycemic effects of this natural product were assessed in normal and alloxan-diabetic mice model. Animals received orally administration of the sesquiterpene glycoside in dose of 25 and 75 mg/kg. The anti-hyperglycemic effect was compared with gliclazide's. The dose of 25 and 75 mg/kg both exerted a significant (p<0.05) hypoglycemic effect in alloxan-diabetic mice throughout the test and a slight effect in normal mice.
Chen
J
J
Institute of Botany (Nanjing Botanical Garden, Mem. Sun Yet-sen), Jiangsu Province and Chinese Academy of Sciences, Nanjing, China.
Li
W L
WL
Wu
J L
JL
Ren
B R
BR
Zhang
H Q
HQ
D000284:Administration, Oral; D000496:Alloxan; D000818:Animals; D001786:Blood Glucose / Q000187:drug effects; D002240:Carbohydrate Sequence; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced / Q000188:drug therapy*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D031983:Eriobotrya / Q000737:chemistry*; D005907:Gliclazide / Q000008:administration & dosage; D006027:Glycosides / Q000008:administration & dosage* / Q000302:isolation & purification; D007004:Hypoglycemic Agents / Q000008:administration & dosage* / Q000302:isolation & purification; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D008968:Molecular Conformation; D008969:Molecular Sequence Data; D009844:Oligosaccharides / Q000008:administration & dosage* / Q000302:isolation & purification; D018515:Plant Leaves / Q000737:chemistry*; D012717:Sesquiterpenes / Q000008:administration & dosage* / Q000302:isolation & purification
D001786:Blood Glucose; D006027:Glycosides; D007004:Hypoglycemic Agents; D009844:Oligosaccharides; D012717:Sesquiterpenes; C529151:nerolidol-3-O-rhamnopyranosyl-1-4-rhamnopyranosyl-1-2-(rhamnopyranosyl-1-6)-glucopyranoside; D000496:Alloxan; D005907:Gliclazide