[Particular features of the clinical manifestation, course and treatment effects of stomach and duodenal ulcers depending on the functional activity of ribosomal genes].
The article presents a study of the functional activity of ribosomal genes in 134 patients with gastric and duodenal ulcer and 48 healthy subjects. A statistically significant reduction of this parameter for patients with peptic ulcer vs. the general population was shown. The authors demonstrated the relation between specific features of the peptic ulcer clinical picture, its progress, results of treatment of these disease entities and functional activity of ribosomal genes. The relation between the functional activity of ribosomal genes, ulcer localization and progress of ulcer complications was demonstrated. The results achieved suggest that the protein synthesis system is involved in all stages of peptic ulcer pathogenesis and sanogenesis.
Kolchanova
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D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D020732:Cytogenetic Analysis; D005260:Female; D015870:Gene Expression; D006801:Humans; D008297:Male; D008875:Middle Aged; D009697:Nucleolus Organizer Region / Q000737:chemistry*; D010437:Peptic Ulcer / Q000175:diagnosis* / Q000188:drug therapy / Q000235:genetics; D014176:Protein Biosynthesis / Q000235:genetics; D012335:RNA, Ribosomal / Q000032:analysis*; D012270:Ribosomes / Q000235:genetics*; D016622:Silver Staining; D016896:Treatment Outcome
D012335:RNA, Ribosomal