Oleanane-type triterpenes from the flowers, pith, leaves, and fruit of Tetrapanax papyriferus.
Four oleanane-type triterpenes, 3alpha,21beta,22alpha-trihydroxy-11,13(18)-oleanadien-28-oic acid (1), 3-epi-papyriogenin C (2), 21-O-acetyl-21-hydroxy-3-oxo-11,13(18)-oleanadien-28-oic acid (3) and 3beta-hydroxy-21-oxo-11,13(18)-oleanadien-28-oic acid methyl ester (4), together with four known triterpenes, were isolated from Tetrapanax papyriferus (Hook) K. Koch. Papyriogenin A (8) exhibited anti-HIV activity and low cytotoxicity in acutely infected H9 lymphocytes. Their structures were determined by analysis of spectroscopic data, including by 1D and 2D NMR.
Ho
Jiau-Ching
JC
Department of Chemical and Materials Engineering, Ta Hwa Institute of Technology, Chung-Lin, Hsinchu, 307 Taiwan, ROC.
Chen
Chiu-Ming
CM
Row
Lie-Ching
LC
D000818:Animals; D019380:Anti-HIV Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D019661:Apiaceae / Q000737:chemistry*; D001156:Artemia / Q000187:drug effects; D035264:Flowers / Q000737:chemistry*; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008516:Medicine, Chinese Traditional; D009828:Oleanolic Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification; D018515:Plant Leaves / Q000737:chemistry*; D012639:Seeds / Q000737:chemistry*; D013624:Taiwan
D019380:Anti-HIV Agents; D000893:Anti-Inflammatory Agents; D010936:Plant Extracts; C413246:oleanane; C038914:papyriogenin A; D009828:Oleanolic Acid