title: Clubbed thiazoles by MAOS: a novel approach to cyclin-dependent kinase 5/p25 inhibitors as a potential treatment for Alzheimer's disease.
abstract: A novel clubbed triazolyl thiazole series of cdk5/p25 inhibitors, potentially useful for the treatment of Alzheimer's disease, is disclosed. Evaluation of the SAR of substitution within these series has allowed the identification of a range of compounds which significantly reduce brain cdk5/p25 and thus have potential as possible treatments for Alzheimer's disease.
authors.affiliation: Dr. Reddys Laboratories, 7-1-27 Ameerpet, Hyderabad 16, Andhra Pradesh, India. rrshiradkar@rediffmail.com
authors.forename: Mahendra Ramesh
authors.initials: MR
authors.lastname: Shiradkar
authors.forename: Kalyan Chakravarthy
authors.initials: KC
authors.lastname: Akula
authors.forename: Varaprasad
authors.initials: V
authors.lastname: Dasari
authors.forename: Vijayakumar
authors.initials: V
authors.lastname: Baru
authors.forename: Bhoomeshwar
authors.initials: B
authors.lastname: Chiningiri
authors.forename: Santosh
authors.initials: S
authors.lastname: Gandhi
authors.forename: Ranjit
authors.initials: R
authors.lastname: Kaur
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy*; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000201:enzymology; D002522:Chlorocebus aethiops; D051360:Cyclin-Dependent Kinase 5 / Q000037:antagonists & inhibitors*; D004353:Drug Evaluation, Preclinical; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000627:therapeutic use; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D008872:Microwaves; D013329:Structure-Activity Relationship; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D014709:Vero Cells
chemical_list: D004791:Enzyme Inhibitors; D007202:Indicators and Reagents; D013844:Thiazoles; D051360:Cyclin-Dependent Kinase 5