title: Synthesis and antibacterial activity of 4,5,6,7-tetrahydro-thieno[3,2-c]pyridine quinolones.
abstract: Synthesis and antibacterial activity of a number of substituted 4,5,6,7-tetrahydro-thieno[3,2-c]pyridine quinolones is reported. The antibacterial activities were evaluated in standard in vitro MIC assay method. Some of the compounds showed in vitro (MIC) antibacterial activity comparable to those of Gatifloxacin, Ciprofloxacin, and Sparfloxacin.
authors.affiliation: Zydus Research Centre, Sarkhej-Bavla N.H. 8A, Moraiya, Ahmedabad, Gujarat 382210, India. brijeshsrivastava@zyduscadila.com
authors.forename: Brijesh Kumar
authors.initials: BK
authors.lastname: Srivastava
authors.forename: Manish
authors.initials: M
authors.lastname: Solanki
authors.forename: Bhupendra
authors.initials: B
authors.lastname: Mishra
authors.forename: Rina
authors.initials: R
authors.lastname: Soni
authors.forename: Sanjaya
authors.initials: S
authors.lastname: Jayadev
authors.forename: Darshan
authors.initials: D
authors.lastname: Valani
authors.forename: Mukul
authors.initials: M
authors.lastname: Jain
authors.forename: Pankaj R
authors.initials: PR
authors.lastname: Patel
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000494:pharmacology; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D002939:Ciprofloxacin / Q000494:pharmacology; D015195:Drug Design; D004353:Drug Evaluation, Preclinical; D004352:Drug Resistance, Microbial; D024841:Fluoroquinolones / Q000494:pharmacology; D000077734:Gatifloxacin; D008826:Microbial Sensitivity Tests; D008956:Models, Chemical; D008968:Molecular Conformation; D011725:Pyridines / Q000737:chemistry*; D015363:Quinolones / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D011725:Pyridines; D015363:Quinolones; D002939:Ciprofloxacin; D000077734:Gatifloxacin; C061363:sparfloxacin