title: [Research advances in human mitochondrial DNA with aging and degenerative diseases].
abstract: The human mitochondrial genome consists of approximate 1500 genes, among which 37 are encoded by the mitochondrial DNA (mtDNA) and the remainder encoded in the nuclear DNA (nDNA). The mitochondria produces large amount of the cellular reactive oxygen species (ROS). ROS induces the mutations of mtDNA and mtDNA, which are associated with a wide range of age-related diseases including neurodegenerative diseases, cardiomyopathy, diabetes and various cancers.
authors.affiliation: Department of Biochemistry and Genetics, Center for Genetic and Genomic Medicine, Institute of Cell Biology, College of Medicine, Zhejiang University, Hangzhou 310058, China.
authors.forename: Dong-Dong
authors.initials: DD
authors.lastname: Ti
authors.forename: Xian-Ning
authors.initials: XN
authors.lastname: Zhang
mesh_terms: D000375:Aging; D004272:DNA, Mitochondrial / Q000235:genetics*; D015316:Genetic Therapy; D006801:Humans; D008928:Mitochondria / Q000235:genetics / Q000378:metabolism; D009154:Mutation; D019636:Neurodegenerative Diseases / Q000235:genetics* / Q000628:therapy; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D004272:DNA, Mitochondrial; D017382:Reactive Oxygen Species