title: [Acute management and secondary prevention of ischemic stroke].
abstract: Stroke is a medical emergency. Intravenous administration of recombinant tissue-type plasminogen activator (rt-PA) within three hours of stroke onset is the only pharmacological treatment proven effective in ischemic stroke. Its efficacy is time dependent. Patients must be carefully selected and treated in dedicated stroke units to reduce the risk of hemorrhage. Early treatment in dedicated stroke units reduces mortality and disability, independent of any specific treatment. Secondary prevention includes antiplatelet therapy and successful control of all risk factors (hypertension, diabetes, tobacco use, and hyperlipidemia). Carotid endarterectomy may be considered if the residual disability is not serious. Lowering blood pressure is beneficial even when initial blood pressure is normal. Lowering LDL-C with statins after ischemic stroke reduces the risk of recurrent stroke and coronary events.
authors.affiliation: Unité neurovasculaire, Centre hospitalo-universitaire, Nice. mahagne.h@chu-nice.fr
authors.forename: Marie-Hélène
authors.initials: MH
authors.lastname: Mahagne
mesh_terms: D001794:Blood Pressure / Q000502:physiology; D002544:Cerebral Infarction / Q000188:drug therapy* / Q000517:prevention & control; D005343:Fibrinolytic Agents / Q000627:therapeutic use; D006801:Humans; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use; D012307:Risk Factors; D020521:Stroke / Q000188:drug therapy* / Q000517:prevention & control; D015912:Thrombolytic Therapy; D013997:Time Factors; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use
chemical_list: D005343:Fibrinolytic Agents; D010975:Platelet Aggregation Inhibitors; D010959:Tissue Plasminogen Activator