title: Advanced malignant rhabdoid tumor of the ovary effectively responding to chemotherapy: a case report and review of the literature.
abstract: BACKGROUND
  Malignant rhabdoid tumors (MRTs) are highly malignant neoplasms that consist of both renal and extrarenal subtypes. Primary ovarian cases are extremely rare. We herein describe the third known case of ovarian origin, which effectively responded to combination chemotherapy with ifosfamide, epirubicin, and cisplatin (IEP chemotherapy).
  
  
  METHODS
  A 19-year-old woman was diagnosed to have stage IIIc primary MRT of the ovary following the resection of tumors. Two months after surgery, an 8 cm-sized pelvic mass and enlarged retroperitoneal lymphnodes were detected. The patient received intravenous tri-weekly IEP chemotherapy. After the second course of chemotherapy, she demonstrated a complete clinical response.
  
  
  CONCLUSIONS
  Although this type of tumor is quite aggressive and chemotherapy is generally not considered to be effective, IEP chemotherapy may be useful in the treatment of MRT of the ovary.
authors.affiliation: Division of Obstetrics and Gynecology, Department of Cellular Function, Niigata University, Graduate School of Medical and Dental Sciences, Niigata, Japan.
authors.forename: Chiaki
authors.initials: C
authors.lastname: Banzai
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Yahata
authors.forename: Jun
authors.initials: J
authors.lastname: Sasahara
authors.forename: Katsunori
authors.initials: K
authors.lastname: Kashima
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Fujita
authors.forename: Ken
authors.initials: K
authors.lastname: Nishikura
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Ajioka
authors.forename: Teiichi
authors.initials: T
authors.lastname: Motoyama
authors.forename: Kenichi
authors.initials: K
authors.lastname: Tanaka
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002945:Cisplatin / Q000008:administration & dosage; D015251:Epirubicin / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007069:Ifosfamide / Q000008:administration & dosage; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000473:pathology; D018335:Rhabdoid Tumor / Q000188:drug therapy* / Q000473:pathology
chemical_list: D015251:Epirubicin; D002945:Cisplatin; D007069:Ifosfamide