Prevention of recurrent bacterial urinary tract infections by intravesical instillation of hyaluronic acid.
OBJECTIVE
To evaluate the efficacy of vesical instillation of hyaluronic acid against recurrent urinary tract infections.


METHODS
Twenty women with a history of recurrent urinary tract infections each received 9 intravesical instillations of hyaluronic acid over 6 months. Their status was assessed prospectively over 47.6 weeks and compared with a retrospective review of patient charts covering 36.2+/-6.2 weeks.


RESULTS
The total numbers of urinary tract infections were 67 before and 10 after treatment (p<0.001). Thirteen patients (65%) were free of recurrences until the end of the study. One had a recurrence during treatment, and 6 (30%) during follow-up. The number of infections per year per patient was reduced from 4.99+/-0.92 to 0.56+/-0.82 (p<0.001). In women with recurrences, time to recurrence was 178.3+/-25.5 days, compared with 76.7+/-24.6 days before treatment (p<0.001).


CONCLUSIONS
Intravesical instillation of hyaluronic acid is effective in preventing recurrent urinary tract infections.
Lipovac
M
M
Medical University of Vienna, Department of Obstetrics and Gynecology, AKH, Vienna, Austria. markus.lipovac@meduniwien.ac.at
Kurz
C
C
Reithmayr
F
F
Verhoeven
H C
HC
Huber
J C
JC
Imhof
M
M
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000283:Administration, Intravesical; D000293:Adolescent; D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006820:Hyaluronic Acid / Q000627:therapeutic use*; D011446:Prospective Studies; D012189:Retrospective Studies; D055502:Secondary Prevention; D013997:Time Factors; D014552:Urinary Tract Infections / Q000517:prevention & control*
D000276:Adjuvants, Immunologic; D006820:Hyaluronic Acid