title: [A preliminary study of an inherited macrothrombocytopenia disorder with abnormal large granules].
abstract: OBJECTIVE
  To study the platelet morphology and function of an inherited macrothrombocytopenia disorder with abnormal large granules.
  
  
  METHODS
  Platelet size and structure were investigated by both light microscopy and electron microscopy. The platelet membrane expression of GP I b, GP II b, GPIII a, P-selectin and CD63 were analyzed by using respective monoclonal antibodies. Platelet 5-hydroxy-tryptamine was measured with spectrophotofluorometer.
  
  
  RESULTS
  Both the patient and her father had large granules in their platelets, with exocytosis being easily observed. The expressions of GP I b, GP II b and GP II a on the platelets were in normal range, while P-selectin and CD63 were somewhat increased. The abnormal large granules were not the alpha granules, lysosomes or dense bodies.
  
  
  CONCLUSIONS
  Both morphological and functional abnormalities of the platelets from the patient are clearly distinguishable from other hereditary giant platelet disorders. It would probably represent a novel platelet disorder.
authors.affiliation: Jiangsu Institute of Hematology, The First Affiliated Hospital of Suzhou University, Suzhou 215006, China.
authors.forename: Shu-Yan
authors.initials: SY
authors.lastname: Wu
authors.forename: Zhao-Yue
authors.initials: ZY
authors.lastname: Wang
authors.forename: Lan
authors.initials: L
authors.lastname: Dai
authors.forename: Rui
authors.initials: R
authors.lastname: Huang
authors.forename: Xiang-Ying
authors.initials: XY
authors.lastname: Wang
authors.forename: Su-An
authors.initials: SA
authors.lastname: Li
authors.forename: Di-Hua
authors.initials: DH
authors.lastname: Mao
authors.forename: Chang-Geng
authors.initials: CG
authors.lastname: Ruan
mesh_terms: D000328:Adult; D001792:Blood Platelets / Q000378:metabolism / Q000648:ultrastructure*; D005260:Female; D006801:Humans; D039661:Integrin beta3 / Q000096:biosynthesis; D016253:Microscopy, Immunoelectron; D019038:Platelet Glycoprotein GPIb-IX Complex / Q000096:biosynthesis; D040201:Platelet Membrane Glycoprotein IIb / Q000096:biosynthesis; D013921:Thrombocytopenia / Q000235:genetics / Q000473:pathology*
chemical_list: D039661:Integrin beta3; D019038:Platelet Glycoprotein GPIb-IX Complex; D040201:Platelet Membrane Glycoprotein IIb