Determination of parabens and triclosan in indoor dust using matrix solid-phase dispersion and gas chromatography with tandem mass spectrometry.
A simple sample preparation method for the determination of four parabens and triclosan in indoor dust is presented. Analytes were extracted from the sample and isolated from interfering species using the matrix solid-phase dispersion technique. After that, they were silylated and determined by gas chromatography combined to tandem mass spectrometry (GC/MS/MS). The influence of several factors on the yield and selectivity of the extraction was evaluated in detail. Under final working conditions, samples (0.5 g) were mixed with the same amount of anhydrous sodium sulfate and dispersed on 1.25 g of C18. This blend was transferred to the top of a polypropylene cartridge containing 2 g of Florisil. After removing less polar species with 10 mL of dichloromethane, analytes were recovered using 10 mL of acetonitrile. This extract was concentrated to 1 mL, derivatized, and injected in the GC/MS/MS system. Derivatization was carried out at 45 degrees C in 5 min using 100 microL of N-methyl-N-(tert-butyldimethylsilyl) trifluoroacetamide. Quantification limits from 0.6 to 2.6 ng/g and absolute recoveries between 80 and 114% were achieved. Analysis of dust samples demonstrated the presence of the target species in indoor dust from private houses. The highest average concentration (702 ng/g) corresponded to triclosan.
Canosa
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Departamento de Química Analítica, Nutrición y Bromatología, Instituto de Investigación y AnAlisis Alimentario, Universidad de Santiago de Compostela, Santiago de Compostela 15782, Spain.
Rodríguez
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Rubí
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E
Cela
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R
D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D004391:Dust / Q000032:analysis*; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods*; D010226:Parabens / Q000032:analysis*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014260:Triclosan / Q000032:analysis*
D004391:Dust; D010226:Parabens; D014260:Triclosan