title: Heritability and clinical features of multigenerational families with obsessive-compulsive disorder and hoarding.
abstract: To date, only one complete genome screen for obsessive-compulsive disorder (OCD) has been published. That study identified a region of suggestive linkage (maximum lod score of 2.25) with a relatively small sample size (N = 56; 27 with OCD). Additional complete genome screens are needed to confirm this finding and identify other regions of linkage. We present the clinical characteristics and power to detect linkage of 11 multigenerational families with OCD and hoarding (N = 92; 44 with OCD), as well as heritability estimates for several quantitative traits. Families with at least two individuals with OCD were identified through probands with childhood-onset OCD. Expected lod scores were calculated for simulated genetic marker data under an additive and two dominant models assuming a dense SNP marker map. All affected individuals had an early age of onset (18 or younger). Hoarding was present in 46% of subjects. Obsessive-compulsive symptoms and hoarding were highly heritable. The maximum mean expected lod score was 3.31 for OCD and 1.39 for hoarding. We found reasonable power to detect regions of interest (lod = 2) for OCD in these families, but will need to expand our family collection to have adequate power to detect regions of interest for hoarding.
authors.affiliation: Department of Psychiatry, University of California, San Francisco, San Francisco, California 94143-0984, USA. cmathews@lppi.ucsf.edu
authors.forename: Carol A
authors.initials: CA
authors.lastname: Mathews
authors.forename: Caroline M
authors.initials: CM
authors.lastname: Nievergelt
authors.forename: Amin
authors.initials: A
authors.lastname: Azzam
authors.forename: Helena
authors.initials: H
authors.lastname: Garrido
authors.forename: Denise A
authors.initials: DA
authors.lastname: Chavira
authors.forename: Jennifer
authors.initials: J
authors.lastname: Wessel
authors.forename: Monica
authors.initials: M
authors.lastname: Bagnarello
authors.forename: Victor I
authors.initials: VI
authors.lastname: Reus
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: Schork
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D003710:Demography; D005260:Female; D006801:Humans; D008126:Lod Score; D008297:Male; D008875:Middle Aged; D009771:Obsessive-Compulsive Disorder / Q000235:genetics* / Q000523:psychology*; D010375:Pedigree; D019655:Quantitative Trait, Heritable; D012044:Regression Analysis