title: Influence of the extent of hybridization on the hydrodynamic radius of DNA-functionalized gold nanoparticles.
abstract: A combination of fluorescence spectroscopy and dynamic laser light scattering is used to investigate the relationship between the extent of hybridization on the surface of DNA-functionalized gold nanoparticles and the hydrodynamic radius (Rh) of the nanoparticle. The hydrodynamic radius of the DNA-Au conjugate increases measurably only after approximately 5-10 DNA hybridization events and saturates at its maximum value well before the surface is fully loaded.
authors.affiliation: Department of Chemistry and Center for Biologically Inspired Materials and Material Systems, Duke University, Durham, North Carolina 27708, USA.
authors.forename: Jun
authors.initials: J
authors.lastname: Xu
authors.forename: Stephen L
authors.initials: SL
authors.lastname: Craig
mesh_terms: D004247:DNA / Q000737:chemistry*; D006046:Gold / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*; D012996:Solutions; D013050:Spectrometry, Fluorescence; D013499:Surface Properties; D044366:Transition Temperature
chemical_list: D012996:Solutions; D006046:Gold; D004247:DNA