title: Usefulness of two independent histopathological classifications of tumor regression in patients with rectal cancer submitted to hyperfractionated pre-operative radiotherapy.
abstract: OBJECTIVE
  To assess the usefulness of two independent histopathological classifications of rectal cancer regression following neo-adjuvant therapy.
  
  
  METHODS
  Forty patients at the initial stage cT3NxM0 submitted to preoperative radiotherapy (42 Gy during 18 d) and then to radical surgical treatment. The relationship between "T-downstaging" versus regressive changes expressed by tumor regression grade (TRG 1-5) and Nasierowska-Guttmejer classification (NG 1-3) was studied as well as the relationship between TRG and NG versus local tumor stage ypT and lymph nodes status, ypN.
  
  
  RESULTS
  Complete regression (ypT0, TRG 1) was found in one patient. "T-downstaging" was observed in 11 (27.5%) patients. There was a weak statistical significance of the relationship between "T-downstaging" and TRG staging and NG stage. Patients with ypT1 were diagnosed as TRG 2-3 while those with ypT3 as TRG5. No lymph node metastases were found in patients with TRG 1-2. None of the patients without lymph node metastases were diagnosed as TRG 5. Patients in the ypT1 stage were NG 1-2. No lymph node metastases were found in NG 1. There was a significant correlation between TRG and NG.
  
  
  CONCLUSIONS
  Histopathological classifications may be useful in the monitoring of the effects of hyperfractionated preoperative radiotherapy in patients with rectal cancer at the stage of cT3NxM0. There is no unequivocal relationship between "T-downstaging" and TRG and NG. There is some concordance in the assessment of lymph node status with ypT, TRG and NG. TRG and NG are of limited value for the risk assessment of the lymph node involvement.
authors.affiliation: Department of Pathology, Medical University of Silesia, ul. Medykow 14, Katowice 40-754, Poland.
authors.forename: Lukasz
authors.initials: L
authors.lastname: Liszka
authors.forename: Ewa
authors.initials: E
authors.lastname: Zielińska-Pajak
authors.forename: Jacek
authors.initials: J
authors.lastname: Pajak
authors.forename: Dariusz
authors.initials: D
authors.lastname: Gołka
authors.forename: Jacek
authors.initials: J
authors.lastname: Starzewski
authors.forename: Zbigniew
authors.initials: Z
authors.lastname: Lorenc
mesh_terms: D000368:Aged; D003131:Combined Modality Therapy; D019583:Dose Fractionation, Radiation; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D012004:Rectal Neoplasms / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery