title: [Vaccination against pneumococci and hepatitis B in the Dutch National Immunisation Programme].
abstract: All infants in the Netherlands, which are born after March 2006, receive additional vaccinations at the age of 2, 3, 4 and 11 months to protect them against pneumococcal infections. During the same visit to a consultation bureau, the children also receive a combination vaccine against diphtheria, pertussis, tetanus, poliomyelitis and Haemophilus influenzae (DTPa-IPV-Hib). Children of which at least one parent was born in a country where hepatitis B occurs relatively often are also vaccinated in the Netherlands against hepatitis B. This currently pertains to about 15% of all newborns. These children now receive a new combination vaccine in which a hepatitis B component has been added to the DTPa-IPV-Hib components. They will receive this combination vaccine 4 times. This combination vaccine is given during the same visit as the pneumococcal vaccination. Although pneumococcal vaccination may have a somewhat negative effect on the immune response to hepatitis B, it is expected that the new 4-fold vaccination schedule will induce good and long-lasting protection against hepatitis B in the vast majority of the children. About 700 children are born out of mothers infected with hepatitis B each year in the Netherlands. In the new vaccination schedule, they now receive 5 active vaccinations against hepatitis B and are examined serologically on an individual basis in order to detect breakthrough infections. This will also generate greater insight into the efficacy of the different vaccination schemes and intervention programmes to prevent vertical transmission of the virus.
authors.affiliation: Rijksinstituut voor Volksgezondheid en Milieu (RIVM), Centrum Infectieziektebestrijding (CIb), Postbus i, 3720 BA Bilthoven. hein.boot@rivm.nl
authors.forename: H J
authors.initials: HJ
authors.lastname: Boot
authors.forename: L
authors.initials: L
authors.lastname: Schouls
authors.forename: S
authors.initials: S
authors.lastname: Hahné
authors.forename: G A M
authors.initials: GA
authors.lastname: Berbers
authors.forename: M
authors.initials: M
authors.lastname: van de Laar
authors.forename: T G
authors.initials: TG
authors.lastname: Kimman
mesh_terms: D015721:Diphtheria-Tetanus-Pertussis Vaccine / Q000008:administration & dosage / Q000276:immunology; D005260:Female; D018073:Haemophilus Vaccines / Q000008:administration & dosage / Q000276:immunology; D017325:Hepatitis B Vaccines / Q000008:administration & dosage / Q000276:immunology; D006801:Humans; D017589:Immunization Programs; D007115:Immunization Schedule; D007223:Infant; D008297:Male; D009426:Netherlands; D022242:Pneumococcal Vaccines / Q000008:administration & dosage / Q000276:immunology; D011054:Poliovirus Vaccine, Inactivated / Q000008:administration & dosage / Q000276:immunology; D017778:Vaccines, Combined
chemical_list: D015721:Diphtheria-Tetanus-Pertussis Vaccine; D018073:Haemophilus Vaccines; D017325:Hepatitis B Vaccines; D022242:Pneumococcal Vaccines; D011054:Poliovirus Vaccine, Inactivated; D017778:Vaccines, Combined