Synthesis of S-dialkylarsino-3-mercapto-1,2-propanediols and evaluation of their anticancer activity.
Some new S-dialkylarsenic compounds, S-dialkylarsino-3-mercapto-1,2-propanediol (3a-3d) and their derivatives (4a,4b), have been synthesized. They were screened at the National Cancer Institute (NCI) for their anticancer activity against a panel of about 60 human tumor cell lines. Most of them display anticancer activity having GI(50) and LC(50) values at low concentrations and are sensitive to leukemia, renal cancer and prostate cancer cell lines and in which the compound 3c is the most active.
Gao
Mingzhang
M
Department of Chemistry, Texas A&M University, College Station, TX 77843-3255, USA.
Tan
Songde
S
Chen
Yiwen
Y
Zingaro
Ralph A
RA
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D005990:Glycerol / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology*; D006801:Humans; D007202:Indicators and Reagents; D007928:Lethal Dose 50; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D013329:Structure-Activity Relationship; D013438:Sulfhydryl Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*
D000970:Antineoplastic Agents; D007202:Indicators and Reagents; D013438:Sulfhydryl Compounds; D005990:Glycerol