title: Perfused microreactors for liver tissue engineering.
abstract: We developed scalable microreactors that foster the development of 3D microscopic pieces of tissue. By integrating microreactors, reservoirs, and pumps in the multiwell cell culture plate format, we created a high throughput cell culture system. However, in contrast to commonly used 2D static cell culture in multiwell plates, our new system allows 3D perfused cell culture. The system provides a means to conduct assays for toxicology and metabolism and can be used as a model for human diseases such as hepatic diseases, exposure-related pathologies, and cancer.
authors.affiliation: Biological Engineering Division and Biotechnology Process Engineering Center. email: domansky@mit.edu.
authors.forename: K
authors.initials: K
authors.lastname: Domansky
authors.forename: W
authors.initials: W
authors.lastname: Inman
authors.forename: J
authors.initials: J
authors.lastname: Serdy
authors.forename: L
authors.initials: L
authors.lastname: Griffith