title: Nanoscale engineering of a cellular interface with semiconductor nanoparticle films for photoelectric stimulation of neurons.
abstract: The remarkable optical and electrical properties of nanostructured materials are considered now as a source for a variety of biomaterials, biosensing, and cell interface applications. In this study, we report the first example of hybrid bionanodevice where absorption of light by thin films of quantum confined semiconductor nanoparticles of HgTe produced by the layer-by-layer assembly stimulate adherent neural cells via a sequence of photochemical and charge-transfer reactions. We also demonstrate an example of nanoscale engineering of the material driven by biological functionalities.
authors.affiliation: Center for Biomedical Engineering, University of Texas Medical Branch, Galveston, Texas 77555-0456, USA.
authors.forename: Todd C
authors.initials: TC
authors.lastname: Pappas
authors.forename: W M Shan
authors.initials: WM
authors.lastname: Wickramanyake
authors.forename: Edward
authors.initials: E
authors.lastname: Jan
authors.forename: Massoud
authors.initials: M
authors.lastname: Motamedi
authors.forename: Malcolm
authors.initials: M
authors.lastname: Brodwick
authors.forename: Nicholas A
authors.initials: NA
authors.lastname: Kotov
mesh_terms: D000200:Action Potentials / Q000528:radiation effects; D000818:Animals; D002460:Cell Line; D004558:Electric Stimulation; D017669:Mercury Compounds / Q000737:chemistry; D051379:Mice; D008858:Microscopy, Phase-Contrast; D036103:Nanotechnology / Q000379:methods; D009474:Neurons / Q000502:physiology* / Q000528:radiation effects* / Q000648:ultrastructure; D018462:Photobiology; D045663:Quantum Dots; D013691:Tellurium / Q000737:chemistry
chemical_list: D017669:Mercury Compounds; D013691:Tellurium