[Dysregulation of cytokine production by mononuclear cells of peripheral blood in persistent infection with a virus of tick-borne encephalitis].
Tick-borne encephalitis is accompanied by dysregulation of cytokine production of mononuclear leucocytes of peripheral blood. The changes of production of IFN-r by mononuclear leucocytes of peripheral blood positively correlated with a degree of activity of pathological process and intensity of clinical symptoms of neuroninfection. On the contrary, secretion of IL-12 mononuclears directly correlated with virus persistence in the organism and does not depend on clinical presentation of the disease.
Riazantseva
N V
NV
Novitskiĭ
V V
VV
Zima
A P
AP
Zhukova
N G
NG
Pirogova
N P
NP
Naslednikova
I O
IO
Lepekhin
A V
AV
D000293:Adolescent; D000328:Adult; D004675:Encephalitis, Tick-Borne / Q000097:blood / Q000276:immunology / Q000503:physiopathology; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D007075:Immunoglobulin M / Q000276:immunology; D007371:Interferon-gamma / Q000096:biosynthesis* / Q000097:blood / Q000276:immunology; D018664:Interleukin-12 / Q000096:biosynthesis* / Q000097:blood / Q000276:immunology; D007963:Leukocytes, Mononuclear / Q000276:immunology* / Q000378:metabolism*; D008297:Male; D008875:Middle Aged
D007074:Immunoglobulin G; D007075:Immunoglobulin M; D018664:Interleukin-12; D007371:Interferon-gamma