title: Cannabinoid receptors as new targets of antifibrosing strategies during chronic liver diseases.
abstract: Chronic liver injury exposes the patient to liver fibrosis and its end stage, cirrhosis, is a major public health problem worldwide. In western countries, prevailing causes of cirrhosis include chronic alcohol consumption, hepatitis C virus infection and non-alcoholic steatohepatitis. Current treatment of hepatic fibrosis is limited to withdrawal of the noxious agent. Nevertheless, suppression of the cause of hepatic injury is not always feasible and numerous efforts are directed at the development of liver-specific antifibrotic therapies. Along these lines, the authors recently demonstrated that the endocannabinoid system shows promise as a novel target for antifibrotic therapy during chronic liver injury. Indeed, cannabinoid receptors CB1 and CB2 promote dual pro- and antifibrogenic effects, respectively. Therefore, endocannabinoid-based therapies, combining CB2 agonists and CB1 antagonists may open novel therapeutic perspectives for the treatment of chronic liver diseases.
authors.affiliation: INSERM, Unité 841, Institut Mondor de Recherche Biomédicale, Université Paris XII-Val de Marne, Créteil, F-94000, France. Sophie.Lotersztajn@creteil.inserm.fr
authors.forename: Ariane
authors.initials: A
authors.lastname: Mallat
authors.forename: Fatima
authors.initials: F
authors.lastname: Teixeira-Clerc
authors.forename: Vanessa
authors.initials: V
authors.lastname: Deveaux
authors.forename: Sophie
authors.initials: S
authors.lastname: Lotersztajn
mesh_terms: D000818:Animals; D006801:Humans; D008103:Liver Cirrhosis / Q000188:drug therapy* / Q000378:metabolism; D008107:Liver Diseases / Q000188:drug therapy* / Q000378:metabolism; D043884:Receptor, Cannabinoid, CB1 / Q000037:antagonists & inhibitors* / Q000378:metabolism; D043885:Receptor, Cannabinoid, CB2 / Q000819:agonists* / Q000378:metabolism
chemical_list: D043884:Receptor, Cannabinoid, CB1; D043885:Receptor, Cannabinoid, CB2