[Evaluation of plasma endothelin-1 concentration in tobacco smoking patients with essential hypertension].
An evident influence of nicotine on vasoconstrictive and mitogenic peptide-- endothelin-1 (ET-1) synthesis and expression of its receptors was observed in experimental investigations. The aim of this study was ET-1 concentration assessment in patients with essential arterial hypertension, regarding nicotine action as ET-1 production stimulant. The investigation enrolled 27 patients with essential hypertension (degree I and II). This group was divided into 2 subgroups: A--11 tobacco smokers and B--16 non-smokers. Both subgroups did not differ as for basic laboratory investigations. Smokers had considerably higher ET-1 concentration than non-smokers. These results may be explained by presented in this paper mechanisms of nicotine on ET-1 influence. Thus smoking cessation in hypertensive patients is very important also because of interactions mentioned above.
Kosicka
Teresa
T
Katedra i Klinika Nadciśnienia Tetniczego, Chorób Naczyń i Chorób Wewnetrznych, Akademii Medycznej w Poznaniu.
Kara-Perz
Hanna
H
Perz
Stanisław
S
D000368:Aged; D015415:Biomarkers / Q000097:blood; D015897:Comorbidity; D019332:Endothelin-1 / Q000097:blood*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D012907:Smoking / Q000097:blood* / Q000453:epidemiology; D016540:Smoking Cessation / Q000706:statistics & numerical data
D015415:Biomarkers; D019332:Endothelin-1