title: Metabolic syndrome and arterial stiffness: the Health 2000 Survey.
abstract: Metabolic syndrome and its components have been associated with arterial stiffness and cardiovascular disease. The objective of this study was to examine the independent influences of metabolic syndrome, its components, and other cardiovascular risk factors on arterial stiffness as well as to compare 2 definitions for metabolic syndrome (National Cholesterol Education Program [NCEP] and International Diabetes Federation [IDF]) in their ability to identify subjects with arterial stiffness. The study population consisted of 401 Finnish men and women aged 45 years and older who participated in a substudy of the Finnish population-based Health 2000 Survey. Pulse wave velocity (PWV) measured by whole-body impedance cardiography was used as a marker of elevated arterial stiffness. In multivariate models, systolic blood pressure, age, waist circumference, and fasting blood glucose (P < or = .001 for all) were independent determinants for PWV. In the models including metabolic syndrome instead of its components, the NCEP and IDF definitions were similarly associated with PWV (P < or = .01 for both), the other independent determinants being age, sex (P < .001 for both) and plasma C-reactive protein concentration (P = .016 and P = .005 in models containing the NCEP and IDF definitions, respectively). Systolic blood pressure, age, waist circumference, and fasting blood glucose level were independently associated with increased arterial stiffness. Metabolic syndrome determined increased arterial stiffness independently of other known cardiovascular risk factors. The NCEP and IDF definitions did not differ in their ability to identify subjects with increased arterial stiffness.
authors.affiliation: Department of Clinical Physiology, Tampere University Hospital, FI-33521 Tampere, Finland. kalle.sipila@uta.fi
authors.forename: Kalle
authors.initials: K
authors.lastname: Sipilä
authors.forename: Teemu
authors.initials: T
authors.lastname: Koivistoinen
authors.forename: Leena
authors.initials: L
authors.lastname: Moilanen
authors.forename: Tuomo
authors.initials: T
authors.lastname: Nieminen
authors.forename: Antti
authors.initials: A
authors.lastname: Reunanen
authors.forename: Antti
authors.initials: A
authors.lastname: Jula
authors.forename: Veikko
authors.initials: V
authors.lastname: Salomaa
authors.forename: Risto
authors.initials: R
authors.lastname: Kaaja
authors.forename: Tiit
authors.initials: T
authors.lastname: Kööbi
authors.forename: Katriina
authors.initials: K
authors.lastname: Kukkonen-Harjula
authors.forename: Silja
authors.initials: S
authors.lastname: Majahalme
authors.forename: Mika
authors.initials: M
authors.lastname: Kähönen
mesh_terms: D000368:Aged; D001158:Arteries / Q000503:physiopathology*; D001783:Blood Flow Velocity; D002097:C-Reactive Protein / Q000032:analysis; D002307:Cardiography, Impedance; D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000503:physiopathology*; D008875:Middle Aged; D011673:Pulsatile Flow
chemical_list: D008078:Cholesterol, LDL; D002097:C-Reactive Protein