Quantitative description and model of molecule transport through skin.
The illustration of the electrical properties of skin and quantitative relations provides the theory and method for transdermal drug delivery by electroporation. The paper puts forward an electrical model of skin including conductance of appendageal, lipid, lipid-corneocyte matrix pathway and Nernst potential of charged drug molecule. Leakage experiments with Tinidazole as pattern mass were carried out with three groups, each of which contained 15 protocols. The result indicates that (1) we obtained that equivalent resistance R(T) of side-by-side permeation chambers and one R(A) of transdermal decreased along with initial voltage of pulse increased using logarithm trend line fitting, but the R(T) and R(A) were gained along with pulse voltage decreased during pulse duty; (2) Even if same pulse protocol, Tinidazole permeation fluxes were difference 0-4 orders from each other for SC of different position at same time. The transdermal potential is actual exist in the molecular to pass through skin. In is more significant that conductance Ga, Gl and Gc is described permeability of molecular through skin. And it shows that electrical model of skin to expatiate quantify relationship between electrical property and molecular flow is very effective.
Jiali
Bao
B
College of Medicine, Zhejiang University, Hangzhou, 310006, China. baojl@zju.edu.cn
Hong
Wang
W
Huiping
Wang
W
Jiguang
Ge
G