title: Low bone mineral density in young children with cystic fibrosis.
abstract: BACKGROUND
  Low bone mineral density (BMD) is a frequent problem for adult patients with cystic fibrosis (CF). Only limited information is available for young patients.
  
  
  OBJECTIVE
  The aim of this study was to evaluate BMD of children with CF younger than 6 years.
  
  
  METHODS
  BMD was measured at the lumbar spine (LS) after adjustment for height, sex, and pubertal status in 25 children with CF younger than 6 years, 53 prepubertal children aged 6 to 10 years, and 36 adolescents aged 11 to 18 years. Nutritional status, body composition, pulmonary disease severity, corticosteroid usage, dietary calcium, caloric intake, and vitamin D status were evaluated as potential correlates of BMD.
  
  
  RESULTS
  The mean LS z score in the youngest group was significantly lower than normal (-0.96; SEM, 0.3). It did not differ significantly from that of children aged 6 to 10 years (-0.91; SEM, 0.2) or adolescents (-1.4; SEM, 0.2). LS z score was positively correlated with fat-free mass in multiple regression analysis. LS z score was less than -1 in 34% of the patients with mild pulmonary disease and normal nutritional status.
  
  
  CONCLUSIONS
  These data suggest that the origin of CF bone disease in early childhood may be independent of nutritional status or disease severity.
authors.affiliation: Service de Pédiatrie Générale, 149 rue de Sévres, Paris, France. isabelle.sermet@nck.aphp.fr
authors.forename: Isabelle
authors.initials: I
authors.lastname: Sermet-Gaudelus
authors.forename: Jean Claude
authors.initials: JC
authors.lastname: Souberbielle
authors.forename: Jean Charles
authors.initials: JC
authors.lastname: Ruiz
authors.forename: Stephanie
authors.initials: S
authors.lastname: Vrielynck
authors.forename: Blandine
authors.initials: B
authors.lastname: Heuillon
authors.forename: Imrana
authors.initials: I
authors.lastname: Azhar
authors.forename: Aline
authors.initials: A
authors.lastname: Cazenave
authors.forename: Ethel
authors.initials: E
authors.lastname: Lawson-Body
authors.forename: Frédérique
authors.initials: F
authors.lastname: Chedevergne
authors.forename: Gérard
authors.initials: G
authors.lastname: Lenoir
mesh_terms: D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage; D000367:Age Factors; D001823:Body Composition; D015519:Bone Density; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D003550:Cystic Fibrosis / Q000097:blood / Q000188:drug therapy / Q000503:physiopathology*; D004032:Diet; D005260:Female; D006801:Humans; D008297:Male; D009752:Nutritional Status; D012720:Severity of Illness Index; D014807:Vitamin D / Q000097:blood
chemical_list: D000305:Adrenal Cortex Hormones; D014807:Vitamin D