[Molecular characteristics of dendritic cells from newborn infants].
The immaturity of the immune system represents a significant challenge for the induction of protective immune responses in early life. In the context of this work, we evaluated the function of human neonatal dendritic cells. We observed that their capacity to produce interleukin-12 and interferon-beta, two cytokines involved in anti-infectious responses, was strongly impaired. These results led us to analyze the signaling pathways and the regulatory mechanisms responsible for the control of these genes in both adult and neonatal dendritic cells.
Goriely
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Institut d'Immunologie Médicale-U.L.B.
D003713:Dendritic Cells / Q000276:immunology*; D006801:Humans; D007231:Infant, Newborn; D016899:Interferon-beta / Q000096:biosynthesis / Q000235:genetics; D018664:Interleukin-12 / Q000096:biosynthesis / Q000235:genetics
D018664:Interleukin-12; D016899:Interferon-beta