Amisulpride augmentation after the failure of citalopram for depression: a case report.
This case report describes a 35-year-old woman with a first depressive episode. She was treated with the serotonergic antidepressant citalopram for 12 weeks without therapeutic response. Low-dose amisulpride augmentation resulted in a significant clinical improvement. We hypothesize that the dopaminergic properties of amisulpride might augment the effects of serotonergic antidepressants in refractory patients.
Carvalho
A F
AF
Department of Clinical Medicine, Psychiatry Outpatient Clinics, Federal University of Ceará, Fortaleza, CE, Brazil. andrefc7@terra.com.br
Nunes-Neto
P R
PR
Cavalcante
J L
JL
Oliveira Lima
M C
MC
D000328:Adult; D000077582:Amisulpride; D015283:Citalopram / Q000008:administration & dosage / Q000627:therapeutic use*; D003863:Depression / Q000188:drug therapy*; D018492:Dopamine Antagonists / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D017367:Selective Serotonin Reuptake Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use*; D013469:Sulpiride / Q000031:analogs & derivatives* / Q000627:therapeutic use; D017211:Treatment Failure
D000077582:Amisulpride; D015283:Citalopram; D018492:Dopamine Antagonists; D017367:Selective Serotonin Reuptake Inhibitors; D013469:Sulpiride