title: EEG-fMRI in children with pharmacoresistant focal epilepsy.
abstract: OBJECTIVE
  To evaluate the usefulness of EEG-combined functional magnetic resonance imaging (EEG-fMRI) to localize epileptogenic sources.
  
  
  METHODS
  Six children (age 8-15 years) with lesional or nonlesional pharmacoresistant focal epilepsy were studied.
  
  
  RESULTS
  We found significant activations in four children, activation and deactivation in one child, and widespread deactivation in another. In four children, activations colocalized with the presumed location of the epileptic focus, one of which was confirmed by intracranial EEG.
  
  
  CONCLUSIONS
  EEG-fMRI is a promising tool to noninvasively localize epileptogenic regions in children with pharmacoresistant focal epilepsy.
authors.affiliation: Neuroscience Unit, UCL Institute of Child Health, London, United Kingdom. xdetiege@ulb.ac.be
authors.forename: Xavier
authors.initials: X
authors.lastname: De Tiège
authors.forename: Helmut
authors.initials: H
authors.lastname: Laufs
authors.forename: Stewart G
authors.initials: SG
authors.lastname: Boyd
authors.forename: William
authors.initials: W
authors.lastname: Harkness
authors.forename: Philip J
authors.initials: PJ
authors.lastname: Allen
authors.forename: Chris A
authors.initials: CA
authors.lastname: Clark
authors.forename: Alan
authors.initials: A
authors.lastname: Connelly
authors.forename: J Helen
authors.initials: JH
authors.lastname: Cross
mesh_terms: D000293:Adolescent; D001931:Brain Mapping; D002648:Child; D004351:Drug Resistance; D004567:Electrodes, Implanted; D004569:Electroencephalography / Q000295:instrumentation / Q000379:methods*; D004828:Epilepsies, Partial / Q000175:diagnosis* / Q000601:surgery; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods*; D010100:Oxygen / Q000097:blood; D011300:Preoperative Care
chemical_list: D010100:Oxygen