title: Dynamic kinetic resolution of primary amines with a recyclable Pd nanocatalyst for racemization.
abstract: A practical procedure for the dynamic kinetic resolution (DKR) of primary amines has been developed. This procedure employs a palladium nanocatalyst as the racemization catalyst, a commercial lipase (Novozym-435) as the resolution catalyst, and ethyl acetate or ethyl methoxyacetate as the acyl donor. Eleven primary amines and one amino acid amide have been efficiently resolved with good yields (85-99%) and high enantiomeric excesses (97-99%). [reaction: see text]
authors.affiliation: Department of Chemistry, Pohang University of Science and Technology, San-31, Hyojadong, Pohang 790-784, Korea. mjkim@postech.ac.kr
authors.forename: Mahn-Joo
authors.initials: MJ
authors.lastname: Kim
authors.forename: Won-Hee
authors.initials: WH
authors.lastname: Kim
authors.forename: Kiwon
authors.initials: K
authors.lastname: Han
authors.forename: Yoon Kyung
authors.initials: YK
authors.lastname: Choi
authors.forename: Jaiwook
authors.initials: J
authors.lastname: Park