[Lynch syndrome and gynaecologic's cancer: follow-up recommendations].
The Lynch syndrome or HNPCC, is due to a mutation of the genes pertaining to the system MMR. This frequency varies from 1/1000 to 1/400. It's responsible for 6% of endométrial cancers, 2% of ovarian cancers and 1 to 3% of colorectal cancers. A good knowledge of this syndrome is necessary for doing the diagnosis and adjustment of gynaecological and colorectal follow-up. The authors report four cases in Lynch syndrome family.
Magri
K
K
Service de Chirurgie Générale, Viscérale et Vasculaire, CHG de Lons-le-Saunier, 55, rue du Docteur-Jean-Michel, BP 364, 39016 Lons-le-Saunier cedex, France. keith.magri@wanadoo.fr
Millon
G
G
D000368:Aged; D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000150:complications / Q000175:diagnosis / Q000235:genetics; D016889:Endometrial Neoplasms / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics*; D010375:Pedigree; D012307:Risk Factors