title: HLA-DRB1*03 is a susceptibility gene in patients with Graves' disease with and without ophthalmopathy.
abstract: We sought an association between certain human leucocyte antigen (HLA) markers and Graves' disease (GD) with and without ophthalmopathy (OP). One hundred and thirty-one Turkish patients with GD (50 without OP, 81 with OP) and 250 local healthy controls were studied. HLA-DRB1 typing was performed by using polymerase chain reaction-sequence-specific primers (PCR-SSP) method. The frequencies of DRB1*03 was significantly increased in GD compared to controls (OR = 2.07; 95% CI = 1.24-3.44), whereas DRB1*13 (OR = 0.33; 95% CI = 0.18-0.61) and DRB1*07 (OR = 0.31; 95% CI = 0.13-0.70) were significantly increased in controls compared to patients. None of the three associations showed any specificity to the OP group.
authors.affiliation: Department of Internal Medicine, Istanbul Medical Faculty, Istanbul University, Turkey.
authors.forename: S
authors.initials: S
authors.lastname: Yarman
authors.forename: F
authors.initials: F
authors.lastname: Oguz
authors.forename: M
authors.initials: M
authors.lastname: Carin
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006111:Graves Disease / Q000235:genetics*; D049970:Graves Ophthalmopathy / Q000235:genetics*; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains