title: Lymphoplasmacytic lymphoma associated with polyradiculoneuritis and cryoglobulinemia mimicking polyarteritis nodosa.
abstract: BACKGROUND
  Systemic vasculitis is sometimes associated with malignant blood disease.
  
  
  METHODS
  We describe the case of a 77-year-old woman who had extensive livedo racemosa, acute polyradiculoneuritis, and meningeal hemorrhage. The skin biopsy showed evidence of necrotizing angiitis. This vascular involvement resembled polyarteritis nodosa (PAN). Despite corticosteroid and cyclophosphamide treatment, the polyradiculoneuritis worsened and the patient died of acute respiratory failure. Type II cryoglobulinemia was detected late, and the autopsy revealed lymphoplasmacytic lymphoma involving the spleen and infiltrating nerve roots, together with necrotizing angiitis involving small-sized arteries.
  
  
  CONCLUSIONS
  This case shows that necrotizing angiitis involving small arteries may occur with type II cryoglobulinemia.
authors.affiliation: Paris-Descartes University, Faculty of Medicine, Department of Internal Medicine and National Reference Center for Vasculitides, Cochin Hospital, AP-HP, Paris. luc.mouthon@cch.ap-hop-paris.fr
authors.forename: Luc
authors.initials: L
authors.lastname: Mouthon
authors.forename: Philippe
authors.initials: P
authors.lastname: Guilpain
authors.forename: Antoine
authors.initials: A
authors.lastname: Martin
authors.forename: Claire
authors.initials: C
authors.lastname: Larroche
authors.forename: Marie Hélène
authors.initials: MH
authors.lastname: André
authors.forename: Sébastien
authors.initials: S
authors.lastname: Fouéré
authors.forename: Liliane
authors.initials: L
authors.lastname: Laroche
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Apartis
authors.forename: Loïc
authors.initials: L
authors.lastname: Guillevin
mesh_terms: D000368:Aged; D003449:Cryoglobulinemia / Q000209:etiology*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000175:diagnosis*; D010488:Polyarteritis Nodosa / Q000175:diagnosis; D011129:Polyradiculoneuropathy / Q000209:etiology*