Deletion of fetA gene sequences in serogroup B and C Neisseria meningitidis isolates.
The immunogenic iron-regulated FetA outer membrane protein of Neisseria meningitidis is one of various outer membrane proteins that have been considered potential meningococcal vaccine candidates. In this report, we describe the characterization of three meningococcal isolates that have deleted fetA sequences through genetic recombination at repetitive elements.
Marsh
Jane W
JW
University of Pittsburgh School of Medicine, 865 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261, USA. marshj@dom.pitt.edu
O'Leary
Mary M
MM
Shutt
Kathleen A
KA
Harrison
Lee H
LH
D001425:Bacterial Outer Membrane Proteins / Q000235:genetics*; D001483:Base Sequence; D004269:DNA, Bacterial / Q000737:chemistry / Q000235:genetics; D005798:Genes, Bacterial; D006801:Humans; D008589:Meningococcal Infections / Q000382:microbiology; D008969:Molecular Sequence Data; D038541:Neisseria meningitidis, Serogroup B / Q000235:genetics* / Q000302:isolation & purification; D038542:Neisseria meningitidis, Serogroup C / Q000235:genetics* / Q000302:isolation & purification; D011995:Recombination, Genetic; D012091:Repetitive Sequences, Nucleic Acid / Q000235:genetics; D017384:Sequence Deletion
D001425:Bacterial Outer Membrane Proteins; D004269:DNA, Bacterial; C093120:FrpB protein, bacteria