title: Surface analysis of peptide mass spectra to improve time and mass localization.
abstract: Current peak detections algorithms for processing mass spectrometry (MS) spectra generally rely on two dimensional techniques for identifying the location and intensity of peaks from a single spectrum. However, when high performance liquid chromatography (HPLC) is coupled with mass spectrometry, a third dimension, retention time, is introduced. The ensemble of MS spectra may then be regarded as a 3D surface where spectral intensity is a function of m/z (mass-to-charge) and time. This suggests that peak localization can be improved by incorporating the time domain data and average data across both dimensions. This work describes a surface intensity analysis algorithm and the results of its use.
authors.affiliation: Dept. of Biomedical Eng., McGill Univ., Que., Canada.
authors.forename: B
authors.initials: B
authors.lastname: Carrillo
authors.forename: R E
authors.initials: RE
authors.lastname: Kearney
authors.forename: C
authors.initials: C
authors.lastname: Yanofsky
authors.forename: K
authors.initials: K
authors.lastname: Lekpor
authors.forename: A
authors.initials: A
authors.lastname: Bell
authors.forename: D
authors.initials: D
authors.lastname: Boismenu