Methylation: a regulator of HIV-1 replication?
Recent characterizations of methyl transferases as regulators of cellular processes have spurred investigations into how methylation events might influence the HIV-1 life cycle. Emerging evidence suggests that protein-methylation can positively and negatively regulate HIV-1 replication. How DNA- and RNA- methylation might impact HIV-1 is also discussed.
Yedavalli
Venkat R K
VR
Molecular Virology Section, Laboratory of Molecular Microbiology, NIAID, the National Institutes of Health, Bethesda, Maryland 20892, USA. vyedavalli@mail.nih.gov
Jeang
Kuan-Teh
KT
D002460:Cell Line; D019175:DNA Methylation; D004279:DNA, Viral / Q000378:metabolism; D015967:Gene Expression Regulation, Viral; D015497:HIV-1 / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D008745:Methylation; D008780:Methyltransferases / Q000378:metabolism*; D012367:RNA, Viral / Q000378:metabolism; D014764:Viral Proteins / Q000378:metabolism*; D014779:Virus Replication
D004279:DNA, Viral; D012367:RNA, Viral; D014764:Viral Proteins; D008780:Methyltransferases