[Effect of watery extract of Orbignya phalerata (babassu) in the gastric healing in rats: morphological and tensiometric study].
BACKGROUND
The large use of plants in the prevention and treatment of different diseases is a milenar practice. In Brazil due to it's rich flora there is a huge material for research and use in popular medicine. The babassu (Orbignya phalerata) is a native tree from North of the Brazil and has a high concentration at the State of Maranhão. The powder of it's mesocarp is known as amid, and has been used as meal and medication due to the known activity against antiinflammatory reaction, pain, pyrexia and immunomodulation.


OBJECTIVE
To analyze the effect of mesocarp of Orbignya phalerata (babassu) in gastric wound healing in rats under morphologic and tensiometric aspects.


METHODS
Forty Wistar rats, male, adults were submitted to a longitudinal incision of 1 cm in the gastric body and sutured with separated stitches of polypropylene 6.0. After this common procedure the animals were allocated in the aleatory way in two groups Orbignya (GO) and Control (GC) with 20 animals each one. In the GO was used intraperitoneal doses of 50 mg/kh of Orbignya phalerata extract and in the GC water 1 ml/kg. Each group was divided in two subgroups of ten rats according to the period of death, at 3rd and 7th post-operative days. After the death, the abdominal cavity was evaluated and the stomach withdrawn. For the comparative analysis between the groups the macroscopic and histological parameters of wound healing were utilized.


RESULTS
There were no abscess, fistulae and haematom in the animals of the study. Abdominal adhesions were observed in both groups of the animals at 3rd and 7th post-operative days. Dehiscence of the gastrography was identified in one 3rd day rat of subgroups GO. The resistance to air insufflation was higher in GO 3rd day (p=0.087). The analysis of histological parameters showed statistical difference related to wound coaptation in favor to subgroup GO 7th post-operative day.


CONCLUSIONS
The extract of mesocarp of Orbignya phalerata in dose and path utilized positively interfered on the gastrography when compared with control group in animals at 7th post-operative day.
Batista
Clelma Pires
CP
Universidade Federal do Maranhao.
Torres
Orlando Jorge Martins
OJ
Matias
Jorge Eduardo F
JE
Moreira
Ana Tereza Ramos
AT
Colman
Daniel
D
Lima
João Henrique Felício de
JH
Macri
Matheus Martin
MM
Rauen
Rêmulo José
RJ
Ferreira
Lydia Masako
LM
de Freitas
Alexandre Coutinho Teixeira
AC
D034861:Abdominal Wall / Q000473:pathology / Q000601:surgery*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D003059:Cocos / Q000737:chemistry*; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use; D011184:Postoperative Period; D051381:Rats; D017208:Rats, Wistar; D018709:Statistics, Nonparametric; D013718:Tensile Strength / Q000187:drug effects; D014945:Wound Healing / Q000187:drug effects*
D000893:Anti-Inflammatory Agents; D010936:Plant Extracts