title: Higher nigrostriatal dopamine neuron loss in early than late onset Parkinson's disease?--a [99mTc]-TRODAT-1 SPECT study.
abstract: Early-onset Parkinson's disease (EOPD) is distinct from the classic late-onset PD (LOPD) because of its slower disease progression. The aim of this study was to compare dopamine neuronal loss in EOPD with that of LOPD with the same disease duration, through dopamine transporter (DAT) estimation. Fourteen patients, seven EOPD (<50 years) and seven LOPD, matched for disease duration were scanned with [(99m)Tc]-TRODAT-1-SPECT (INER-Taiwan), and were assessed with standard PD scales. EOPD patients had 34% lower striatal DAT binding potential (BP) compared with that of LOPD patients (BP = 0.29 +/- 0.12, BP = 0.44 +/- 0.12, P < 0.02) with similar PD severity. These results suggest that EOPD patients have greater dopamine density loss than LOPD patients without motor-symptom worsening.
authors.affiliation: Laboratório Interdiciplinar de Neuroimagem e Cognição (LiNC), Universidade Federal de São Paulo, Sao Paulo, Brazil. mingchi@psiquiatria.epm.br
authors.forename: Ming Chi
authors.initials: MC
authors.lastname: Shih
authors.forename: Luiz Augusto
authors.initials: LA
authors.lastname: Franco de Andrade
authors.forename: Edson
authors.initials: E
authors.lastname: Amaro
authors.forename: Andre Carvalho
authors.initials: AC
authors.lastname: Felicio
authors.forename: Henrique Ballalai
authors.initials: HB
authors.lastname: Ferraz
authors.forename: Jairo
authors.initials: J
authors.lastname: Wagner
authors.forename: Marcelo Queiroz
authors.initials: MQ
authors.lastname: Hoexter
authors.forename: Li Fu
authors.initials: LF
authors.lastname: Lin
authors.forename: Ying Kai
authors.initials: YK
authors.lastname: Fu
authors.forename: Jair Jesus
authors.initials: JJ
authors.lastname: Mari
authors.forename: Sergio
authors.initials: S
authors.lastname: Tufik
authors.forename: Rodrigo Affonseca
authors.initials: RA
authors.lastname: Bressan
mesh_terms: D000328:Adult; D017668:Age of Onset; D000368:Aged; D003342:Corpus Striatum / Q000000981:diagnostic imaging*; D003863:Depression / Q000453:epidemiology; D004298:Dopamine / Q000032:analysis; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015609:Organotechnetium Compounds; D010300:Parkinson Disease / Q000000981:diagnostic imaging* / Q000523:psychology; D019275:Radiopharmaceuticals; D013378:Substantia Nigra / Q000000981:diagnostic imaging*; D015899:Tomography, Emission-Computed, Single-Photon; D014326:Tropanes
chemical_list: D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; D014326:Tropanes; C104196:technetium Tc 99m TRODAT-1; D004298:Dopamine