Simulating leukocyte-venule interactions--a novel agent-oriented approach.
Leukocyte recruitment into sites of inflammation involves a complex cascade of molecular interactions between the leukocyte and the endothelial cells of the inflamed venule. This report proposes a novel agent-oriented approach for simulating leukocyte-venule interactions during inflammation. We focus on modeling and simulating the initial steps of rolling, activation, and firm adhesion of neutrophils on TNF-alpha-treated mouse cremaster muscle venules.
Tang
J
J
California University, San Francisco, CA, USA.
Hunt
C A
CA
Mellein
J
J
Ley
K
K