Possible anxiolytic effect of two extracts of Passiflora quadrangularis L. in experimental models.
Several species of the genus Passiflora, known in Brazil as 'maracujá', have widespread use in folk medicine as sedatives and anxiolytics. The anxiolytic activities of aqueous and hydroalcohol extracts of Passiflora quadrangularis leaves were evaluated using the elevated plus-maze, open field and holeboard tests. The hydroalcohol extract presented results suggestive of anxiolytic activity in dosages around 100, 250 and 500 mg/kg, as expressed by elevation of the time spent on the open arms in the plus-maze; a decrease of freezing and an increase of deambulation and rearing in the open field test. The hydroalcohol extract showed results similar to diazepam on the holeboard. No positive results were found for the aqueous extract.
de Castro
Pollyanna Celso F
PC
Laboratory of Pharmacology, UEPA, Belém, PA, Brazil.
Hoshino
Alberto
A
da Silva
Jair Campos
JC
Mendes
Fúlvio Rieli
FR
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects; D003975:Diazepam / Q000494:pharmacology; D008297:Male; D051379:Mice; D029598:Passiflora / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar
D014151:Anti-Anxiety Agents; D010936:Plant Extracts; D003975:Diazepam