Neuroligins 3 and 4X interact with syntrophin-gamma2, and the interactions are affected by autism-related mutations.
Recently, neuroligins (NLs)3 and 4X have received much attention as autism-related genes. Here, we identified syntrophin-gamma2 (SNTG2) as a de novo binding partner of NL3. SNTG2 also bound to NL4X and NL4Y. Interestingly, the binding was influenced by autism-related mutations, implying that the impaired interaction between NLs and SNTG2 contributes to the etiology of autism.
Yamakawa
Hidekuni
H
Department of Life Sciences, Graduate School of Arts and Sciences, University of Tokyo, Tokyo, 3-8-1 Komaba, Meguro-ku 153-8902, Japan.
Oyama
Satoko
S
Mitsuhashi
Hiroaki
H
Sasagawa
Noboru
N
Uchino
Shigeo
S
Kohsaka
Shinichi
S
Ishiura
Shoichi
S
D001321:Autistic Disorder / Q000235:genetics* / Q000473:pathology; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism*; D015816:Cell Adhesion Molecules, Neuronal; D003001:Cloning, Molecular; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism*; D009124:Muscle Proteins / Q000235:genetics / Q000378:metabolism*; D009154:Mutation; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism*; D011993:Recombinant Fusion Proteins / Q000378:metabolism; D011994:Recombinant Proteins / Q000378:metabolism; D015183:Restriction Mapping; D012441:Saccharomyces cerevisiae / Q000235:genetics; D013569:Synapses / Q000473:pathology; D005680:gamma-Aminobutyric Acid / Q000502:physiology
D002352:Carrier Proteins; D015816:Cell Adhesion Molecules, Neuronal; D008565:Membrane Proteins; D009124:Muscle Proteins; C430845:NLGN4X protein, human; D009419:Nerve Tissue Proteins; D011993:Recombinant Fusion Proteins; D011994:Recombinant Proteins; C410037:SNTG2 protein, human; C098004:neuroligin 3; D005680:gamma-Aminobutyric Acid