[The influence of kynurenic acid on the content of excitatory and inhibitory mediators in rats with different levels of seizure susceptibility].
The influence of per os administered kynurenic acid on the glutamate, aspartate, glycine and GABA levels in the rat brain areas depended on the initial level of seizure susceptibility. The highest resistance of investigated parameters to the influence of kynurenic acid was found in the cerebellum of rats with low seizure susceptibility. The considerable changes of mediator levels in the rats of this group were found in the brain stem. The same direction of changes in the content of all the investigated mediators with exception of aspartate was found in the brain stem of both groups of rats.
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D000161:Acoustic Stimulation; D000596:Amino Acids / Q000378:metabolism*; D000818:Animals; D001224:Aspartic Acid / Q000378:metabolism; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology*; D018698:Glutamic Acid / Q000378:metabolism; D005998:Glycine / Q000378:metabolism; D007736:Kynurenic Acid / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012640:Seizures / Q000378:metabolism*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D000596:Amino Acids; D018691:Excitatory Amino Acid Antagonists; D001224:Aspartic Acid; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid; D007736:Kynurenic Acid; D005998:Glycine