title: The current role of calcineurin inhibitors in posttransplant immunosuppression?
abstract: It is important to determine when to use and when to avoid calcineurin inhibitors (CNIs). CNIs are associated with kidney dysfunction in some, but not all, transplant recipients. CNI-sparing protocols have their own drug-specific limitations. Two major clinical series suggest the benefit of routine CNI-sparing approaches, but our review suggests weaknesses in both. Ongoing studies are needed to determine which subgroups of recipients will benefit from CNIs.
authors.affiliation: Department of Surgery, University of Minnesota, Minneapolis, Minnesota, USA. matas001@umn.edu
authors.forename: A J
authors.initials: AJ
authors.lastname: Matas
authors.forename: R
authors.initials: R
authors.lastname: Kandaswamy
mesh_terms: D065095:Calcineurin Inhibitors; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000627:therapeutic use*; D016030:Kidney Transplantation / Q000276:immunology; D014181:Transplantation Immunology
chemical_list: D065095:Calcineurin Inhibitors; D007166:Immunosuppressive Agents