title: Changes in gingival crevicular fluid interleukin-4 and interferon-gamma in patients with chronic periodontitis before and after periodontal initial therapy.
abstract: Cytokines are pivotal to the immune response of chronic periodontitis. The present study investigated the changes of gingival crevicular fluid (GCF) interleukin-4 (IL-4) and interferon-gamma (IFN-gamma) in patients with chronic periodontitis before and after initial nonsurgical periodontal therapy (NSPT). GCF was collected from 17 patients by means of Periopaper at baseline and 1 month after NSPT. IL-4 and IFN-gamma were measured by enzyme-linked immunoabsorbent assay. NSPT resulted in decreased total amount of IFN-gamma, increased concentration of IL-4, and increased ratio of IL-4 to IFN-gamma levels. We suggest that a low ratio of IL-4 to IFN-gamma levels might be involved in the destruction (diseased sites) of periodontal tissue, whereas an increased ratio of IL-4 to IFN-gamma levels could be related to the improvement of clinical periodontal health.
authors.affiliation: Graduate Institute of Dental Sciences, College of Dental Medicine, Kaohsiung Medical University, and Department of Periodontics, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan. chchts@kmu.edu.tw
authors.forename: Chi-Cheng
authors.initials: CC
authors.lastname: Tsai
authors.forename: Chia-Hsin
authors.initials: CH
authors.lastname: Ku
authors.forename: Ya-Ping
authors.initials: YP
authors.lastname: Ho
authors.forename: Kun-Yen
authors.initials: KY
authors.lastname: Ho
authors.forename: Yi-Min
authors.initials: YM
authors.lastname: Wu
authors.forename: Chun-Cheng
authors.initials: CC
authors.lastname: Hung
mesh_terms: D000328:Adult; D002908:Chronic Disease; D005260:Female; D005883:Gingival Crevicular Fluid / Q000737:chemistry*; D006801:Humans; D007371:Interferon-gamma / Q000032:analysis*; D015847:Interleukin-4 / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D010518:Periodontitis / Q000276:immunology* / Q000628:therapy
chemical_list: D015847:Interleukin-4; D007371:Interferon-gamma