The Na,K-ATPase receptor complex: its organization and membership.
A major difference between the Na,K-ATPase ion pump and other P-type ATPases is its ability to bind cardiotonic steroids such as ouabain. Na,K-ATPase also interacts with many membrane and cytosolic proteins. In addition to their role in Na,K-ATPase regulation, it became apparent that some of the newly identified interactions are capable of organizing the Na,K-ATPase into various signaling complexes. This new function confers a ligand-like effect to cardiotonic steroids on cellular signal transduction. This article reviews these new developments and provides a comparison of Na,K-ATPase-mediated signal transduction with other receptors and ion transporters.
Pierre
Sandrine V
SV
Department of Physiology, Pharmacology, Metabolism and Cardiovascular Sciences, Medical University of Ohio, Toledo, OH 43614, USA.
Xie
Zijian
Z
D000818:Animals; D002118:Calcium / Q000502:physiology; D002301:Cardiac Glycosides / Q000378:metabolism*; D021941:Caveolae / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism; D003593:Cytoplasm / Q000378:metabolism; D006801:Humans; D017136:Ion Transport; D010042:Ouabain / Q000378:metabolism; D011485:Protein Binding; D020033:Protein Isoforms / Q000502:physiology; D011956:Receptors, Cell Surface / Q000378:metabolism / Q000502:physiology*; D015398:Signal Transduction; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism / Q000502:physiology*; D019061:src-Family Kinases / Q000378:metabolism / Q000502:physiology*
D002301:Cardiac Glycosides; D020033:Protein Isoforms; D011956:Receptors, Cell Surface; D010042:Ouabain; D019061:src-Family Kinases; D000254:Sodium-Potassium-Exchanging ATPase; D002118:Calcium