[Epileptogenic activity of tripeptide corticotropin-releasing factor fragment (CRF(4-6))].
The effects of centrally administered tripeptide fragment CRF(4-6) of corticotropin-releasing factor on convulsive activity in outbred albino rats were investigated. The peptide CRF(4-6) (icv; 6, 30, 150 nmol/head) causes dose-dependent increase in total EEG power in 1-40 Hz frequency range as a reflection of tripeptide-induced various epileptiform EEG signs such as single peaks and spike trains without external convulsion. Higher doses of CRF(4-6) (icv; 150, 225, 300 nmol per animal) induce tonicoclonic seizures. Switching to convulsive activity occurs at CRF(4-6) dose of 150 nmol per animal: injection of this dose leads only to EEG paroxysmal activity under habitual conditions and induces pathological locomotor activation under stressing conditions. Thus, CRF(4-6) similarly to full-length corticotropin-releasing factor induces epileptiform activity in rats.
Makarenko
E Iu
EIu
Berdiev
R K
RK
Andreeva
L A
LA
Mart'ianov
A A
AA
D000818:Animals; D003346:Corticotropin-Releasing Hormone / Q000494:pharmacology* / Q000502:physiology; D004569:Electroencephalography; D004827:Epilepsy / Q000503:physiopathology*; D008297:Male; D010446:Peptide Fragments / Q000494:pharmacology* / Q000502:physiology; D051381:Rats
D010446:Peptide Fragments; C488808:prolyl-prolylisoleucine; D003346:Corticotropin-Releasing Hormone