Anti-diarrheal activity of methanol extract of Litsea polyantha bark in mice.
The anti-diarrheal activity of methanol extract of dried bark and aerial parts of Litsea polyantha (MELP) has been evaluated in mice using different models (castor oil-induced diarrhea and propulsive gut motility in mice). MELP (50, 75, 100 mg/kg, p.o.) significantly (P<0.01) reduced the onset of diarrhea, fecal excretion and also showed a significant (P<0.001) reduction in gastrointestinal motility on charcoal meal test in mice. The results of the study support the folklore use of the plant for diarrheal remedies.
Poonia
Brijendra Singh
BS
Division of Pharmacology, Department of Pharmaceutical Sciences, Birla Institute of Technology, Mesra, Ranchi (J.H.), India. biju_poonia@rediffmail.com
Sasmal
D
D
Mazumdar
P M
PM
D000284:Administration, Oral; D000818:Animals; D000930:Antidiarrheals / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D002368:Castor Oil; D003967:Diarrhea / Q000139:chemically induced / Q000517:prevention & control*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects*; D032862:Litsea; D008297:Male; D051379:Mice; D008517:Phytotherapy; D024301:Plant Bark; D035261:Plant Components, Aerial; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use
D000930:Antidiarrheals; D010936:Plant Extracts; D002368:Castor Oil