Transient receptor potential channels as drug targets.
The mammalian transient receptor potential (TRP) superfamily of ion channels consists of voltage-independent, non-selective cation channels that are expressed in excitable and non-excitable cells. The biologic roles of TRP channels are diverse and include vascular tone, thermosensation, irritant stimuli sensing and flow sensing in the kidney. TRP channels are a relatively new target in therapeutic drug discovery. During the past few years, pharmaceutical companies have focused their discovery efforts on developing TRP channel modulators with potential therapeutic value. This review focuses on the potential therapeutic benefits of drugs targeting TRP ion channels.
Okuhara
Dayne Y
DY
Synta Pharmaceuticals Corp., 45 Hartwell Avenue, Lexington, MA 02421, USA. dokuhara@syntapharma.com
Hsia
Albert Y
AY
Xie
Michael
M
D000818:Animals; D002490:Central Nervous System / Q000378:metabolism; D015195:Drug Design; D042783:Endothelial Cells / Q000378:metabolism; D006801:Humans; D032389:Myocytes, Smooth Muscle / Q000378:metabolism; D050051:Transient Receptor Potential Channels / Q000378:metabolism*
D050051:Transient Receptor Potential Channels