Interaction of methylmercury and selenium on the bioaccumulation and histopathology in medaka (Oryzias latipes).
Interaction of methylmercury and selenium in medaka (Oryzias latipes) on bioaccumulation of pollutants and histopathological changes in liver and gill were studied. Juvenile medaka fish were submitted to a series of waterborne methylmercury chloride (MMC), sodium selenite (Na(2)SeO(3)) and their mixture for 210 days, respectively. The methylmercury (MeHg) and selenium contents in the whole body of medaka were determined. The dose- and time-dependent increase of MeHg and selenium contents in medaka were observed. Histopathological changes, such as edema, vacuoles, pyknotic nucleus, and telangiectasis, could clearly be observed in the slices from the exposed medaka's liver and gill. Concurrent exposure to MMC and Na(2)SeO(3) showed the increased selenium accumulation. When the exposure molar ratio of MeHg:Se was about 1, the interaction between MeHg and selenium offered a limited protection against the serious intoxication of both MMC and Na(2)SeO(3) to medaka.
Liao
Chun-Yang
CY
State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, P.O. Box 2871, Beijing 100085, China.
Zhou
Qun-Fang
QF
Fu
Jian-Jie
JJ
Shi
Jian-Bo
JB
Yuan
Chun-Gang
CG
Jiang
Gui-Bin
GB
D000818:Animals; D004305:Dose-Response Relationship, Drug; D005880:Gills / Q000187:drug effects* / Q000473:pathology; D006651:Histocytochemistry; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D008767:Methylmercury Compounds / Q000378:metabolism / Q000633:toxicity*; D009990:Oryzias / Q000378:metabolism*; D018570:Risk Assessment; D012643:Selenium / Q000378:metabolism / Q000633:toxicity*; D018038:Sodium Selenite / Q000378:metabolism / Q000633:toxicity; D013997:Time Factors
D008767:Methylmercury Compounds; D012643:Selenium; D018038:Sodium Selenite; C004925:methylmercuric chloride