Caffeine consumption and methotrexate dosing requirement in psoriasis and psoriatic arthritis.
BACKGROUND
Recent animal and human studies have suggested that the therapeutic benefit of methotrexate in the treatment of rheumatoid arthritis may be substantially reduced in patients who are concomitantly consuming caffeine. Here, we aimed to investigate the effect of caffeine consumption on the methotrexate dosing requirements in patients with psoriasis and psoriatic arthritis.


METHODS
One hundred and fifty patients with diagnoses of psoriasis or psoriatic arthritis were surveyed for their current weekly methotrexate dosage and their usual daily consumption of caffeine.


RESULTS
Seventy-five of the patients given the survey responded; of these, 11 were eliminated because they did not report their methotrexate dosage or were no longer taking methotrexate. Of the remaining 64 patients, no correlation was found between the methotrexate dosage needed for disease maintenance and the amount of caffeine consumed.


CONCLUSIONS
Our findings suggest that caffeine does not affect methotrexate dosage requirements in patients with psoriasis and psoriatic arthritis. These results do not rule out an effect of caffeine in other inflammatory diseases treated with methotrexate.
Swanson
David L
DL
Department of Dermatology, Mayo Clinic, Scottsdale, Arizona 85259, USA. swanson.david@mayo.edu
Barnes
Sunni A
SA
Mengden Koon
Stephanie J
SJ
el-Azhary
Rokea A
RA
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015535:Arthritis, Psoriatic / Q000188:drug therapy*; D002110:Caffeine / Q000494:pharmacology*; D003879:Dermatologic Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D004347:Drug Interactions; D005260:Female; D018565:Food-Drug Interactions; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage / Q000493:pharmacokinetics*; D008875:Middle Aged; D011565:Psoriasis / Q000188:drug therapy*
D003879:Dermatologic Agents; D002110:Caffeine; D008727:Methotrexate