title: Antigenic variation in ciliates: antigen structure, function, expression.
abstract: In the past decades, the major focus of antigen variation research has been on parasitic protists. However, antigenic variation occurs also in free-living protists. The antigenic systems of the ciliates Paramecium and Tetrahymena have been studied for more than 100 yr. In spite of different life strategies and distant phylogenetic relationships of free-living ciliates and parasitic protists, their antigenic systems have features in common, such as the presence of repeated protein motifs and multigene families. The function of variable surface antigens in free-living ciliates is still unknown. Up to now no detailed monitoring of antigen expression in free-living ciliates in natural habitats has been performed. Unlike stochastic switching in parasites, antigen expression in ciliates can be directed, e.g. by temperature, which holds great advantages for research on the expression mechanism. Regulated expression of surface antigens occurs in an exclusive way and the responsible mechanism is complex, involving both transcriptional and post-transcriptional features. The involvement of homology-dependent effects has been proposed several times but has not been proved yet.
authors.affiliation: Department of Ecology, University of Kaiserslautern, Building 14, Gottlieb-Daimler-Street, 67663 Kaiserslautern, Germany. msimon@rhrk.uni-kl.de
authors.forename: Martin C
authors.initials: MC
authors.lastname: Simon
authors.forename: Helmut J
authors.initials: HJ
authors.lastname: Schmidt
mesh_terms: D000818:Animals; D000940:Antigenic Variation / Q000235:genetics; D000953:Antigens, Protozoan / Q000737:chemistry / Q000235:genetics / Q000276:immunology*; D000954:Antigens, Surface / Q000235:genetics / Q000276:immunology; D005786:Gene Expression Regulation; D018503:Genome, Protozoan; D010247:Paramecium / Q000145:classification / Q000235:genetics / Q000276:immunology*; D012703:Serotyping; D015398:Signal Transduction; D013768:Tetrahymena / Q000235:genetics / Q000276:immunology*
chemical_list: D000953:Antigens, Protozoan; D000954:Antigens, Surface