title: Essential tremor: phenotypic expression in a clinical cohort.
abstract: OBJECTIVE
  Examine the characteristics of an essential tremor (ET) clinical cohort including base-rate variability of several commonly accepted diagnostic criteria.
  
  
  METHODS
  A clinical series of 487 consecutive individuals diagnosed with ET were included for study.
  
  
  RESULTS
  The sample was 53% male, had a mean age of onset of 52, and a mean age of 71. Half of the sample had a family history of ET. Half presented with asymmetrical disease and tremor affected the arms (97%), voice (62%), and head or neck (48%). There was considerable variability in the base rate of individuals fulfilling various commonly used diagnostic criteria of ET.
  
  
  CONCLUSIONS
  The sample was deemed representative of ET clinical cohorts. Asymmetric disease was common, and there was considerable base-rate variation across traditional ET diagnostic criteria.
authors.affiliation: Department of Neurology, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32225, USA. whaley.nathaniel@mayo.edu
authors.forename: N R
authors.initials: NR
authors.lastname: Whaley
authors.forename: John D
authors.initials: JD
authors.lastname: Putzke
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Baba
authors.forename: Zbigniew K
authors.initials: ZK
authors.lastname: Wszolek
authors.forename: Ryan J
authors.initials: RJ
authors.lastname: Uitti
mesh_terms: D017668:Age of Onset; D000368:Aged; D015331:Cohort Studies; D003710:Demography; D018450:Disease Progression; D020329:Essential Tremor / Q000175:diagnosis* / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D010641:Phenotype