Differential expression of selected gene products in uterine leiomyomata and adenomyosis.
Gene products estrogen receptor alpha, progesterone receptor-A, retinoid X receptor alpha, insulin-like growth factor-II, insulin-like growth factor I receptor beta, platelet-derived growth factor, epithelial growth factor receptor, and BCL-2 were examined by immunohistochemistry with the aid of a tissue microarray from 46 hysterectomies with adenomyosis and leiomyomata. With appropriate internal controls, there were significant differences in gene expression between adenomyosis and leiomyomata.
Levy
Mary
M
Department of Pathology, New York University School of Medicine, New York, New York 10016, USA.
Mittal
Khush
K
Chiriboga
Luis
L
Zhang
Xinmin
X
Yee
Herman
H
Wei
Jian-Jun
JJ
D000328:Adult; D004715:Endometriosis / Q000235:genetics* / Q000378:metabolism*; D005260:Female; D020869:Gene Expression Profiling; D005819:Genetic Markers / Q000235:genetics; D006801:Humans; D007150:Immunohistochemistry; D018231:Leiomyomatosis / Q000235:genetics* / Q000378:metabolism*; D008875:Middle Aged
D005819:Genetic Markers