title: Macrophage inflammatory protein-1alpha: a link between innate immunity and familial Mediterranean fever?
abstract: The aim of this study is to investigate the relationship between chemokines and the inflammation in Familial Mediterranean Fever (FMF). Forty-nine patients with FMF (41 in remission and 8 in acute attack period) and 20 healthy controls were included in the study. Serum levels of macrophage inflammatory protein-1alpha (MIP-1alpha) were assessed in the patients and the controls, along with other parameters of disease activity, i.e., fibrinogen, C-reactive protein and erythrocyte sedimentation rate. Serum MIP-1alpha levels of the patients with FMF in acute attack period were significantly higher than the patients in remission and healthy controls (p=0.02 and p=0.038, respectively). MIP-1alpha levels were weakly correlated with CRP (r=0.32, p=0.032) levels. MIP-1alpha may have a role in the pathogenesis of FMF attacks. MIP-1alpha and other chemokines may constitute a link between the innate immune system and FMF.
authors.affiliation: Hacettepe University Faculty of Medicine, Department of Internal Medicine, Division of Medical Oncology, 06100 Sihhiye, Ankara, Turkey. omerdiz@yahoo.com
authors.forename: Omer
authors.initials: O
authors.lastname: Dizdar
authors.forename: Umut
authors.initials: U
authors.lastname: Kalyoncu
authors.forename: Omer
authors.initials: O
authors.lastname: Karadag
authors.forename: Ali
authors.initials: A
authors.lastname: Akdogan
authors.forename: Sedat
authors.initials: S
authors.lastname: Kiraz
authors.forename: Ihsan
authors.initials: I
authors.lastname: Ertenli
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Barista
authors.forename: Meral
authors.initials: M
authors.lastname: Calguneri
mesh_terms: D000293:Adolescent; D000328:Adult; D054405:Chemokine CCL3; D054407:Chemokine CCL4; D010505:Familial Mediterranean Fever / Q000097:blood* / Q000276:immunology* / Q000473:pathology; D005260:Female; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology*; D019402:Macrophage Inflammatory Proteins / Q000097:blood*; D008297:Male; D008875:Middle Aged
chemical_list: D054405:Chemokine CCL3; D054407:Chemokine CCL4; D019402:Macrophage Inflammatory Proteins