[Expression and significance of Bmi-1 in breast cancer].
OBJECTIVE
Bmi-1, a putative oncogene, is a member of the polycomb group genes family. It is widely expressed in many kinds of tumors. This study was to investigate the expression and significance of Bmi-1 in breast cancer.


METHODS
The expression of Bmi-1 protein in 58 specimens of breast cancer was detected by immunohistochemistry. The correlation of Bmi-1 expression to clinicopathologic features of breast cancer was analyzed.


RESULTS
The intensive positive rate of Bmi-1 in breast cancer was 82.8%. The intensive expression of Bmi-1 was positively correlated to clinical stage and lymph node metastasis (P < 0.05), but not to tumor size, estrogen receptor (ER), progesterone receptor (PR), c-erbB-2 and vascular endothelial growth factor (VEGF) expression (P>0.05).


CONCLUSIONS
The intensive expression of Bmi-1 in breast cancer is related to tumor progression. Bmi-1 may serve as a new molecular marker of metastasis of breast cancer.
Feng
Yan
Y
State Key Laboratory of Oncology in South China, Guangzhou, Guangdong, PR China.
Song
Li-Bing
LB
Guo
Bao-Hong
BH
Liao
Wen-Ting
WT
Li
Man-Zhi
MZ
Liu
Wan-Li
WL
Zeng
Mu-Sheng
MS
Zhang
Ling
L
D002288:Adenocarcinoma, Mucinous / Q000378:metabolism / Q000473:pathology; D014408:Biomarkers, Tumor / Q000378:metabolism*; D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology; D018270:Carcinoma, Ductal, Breast / Q000378:metabolism* / Q000473:pathology; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007150:Immunohistochemistry; D008207:Lymphatic Metastasis; D009367:Neoplasm Staging; D009687:Nuclear Proteins / Q000378:metabolism*; D063150:Polycomb Repressive Complex 1; D011518:Proto-Oncogene Proteins / Q000378:metabolism*; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000378:metabolism; D011960:Receptors, Estrogen / Q000378:metabolism; D011980:Receptors, Progesterone / Q000378:metabolism; D012097:Repressor Proteins / Q000378:metabolism*; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism
D014408:Biomarkers, Tumor; D009687:Nuclear Proteins; D063150:Polycomb Repressive Complex 1; D011518:Proto-Oncogene Proteins; D018719:Erb-b2 Receptor Tyrosine Kinases; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D012097:Repressor Proteins; D042461:Vascular Endothelial Growth Factor A; C069077:BMI1 protein, human