Treatment of extensive cutaneous metastatic melanoma with topical diphencyprone.
Diphencyprone is a potent contact sensitizer sometimes used to treat alopecia areata and cutaneous warts. A patient with previous primary nodular melanoma on the scalp developed extensive, confluent cutaneous metastases near the primary site, unsuitable for treatment with surgery or radiotherapy. Topical treatment with diphencyprone as a single agent resulted in regression of all lesions, and the patient remains well 18 months later. Topical immunotherapy with diphencyprone was an inexpensive and well-tolerated treatment for extensive cutaneous melanoma metastases in our patient unsuitable for other therapies.
Damian
Diona L
DL
Department of Dermatology, University of Sydney at Royal Prince Alfred Hospital, Australia. diona.damian@email.cs.nsw.gov.au
Thompson
John F
JF
D000287:Administration, Topical; D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D003521:Cyclopropanes / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D008545:Melanoma / Q000188:drug therapy* / Q000556:secondary; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy*; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000556:secondary
D000970:Antineoplastic Agents; D003521:Cyclopropanes; C029402:diphenylcyclopropenone