title: Lung function accurately predicts hypercapnia in patients with Duchenne muscular dystrophy.
abstract: BACKGROUND
  In patients with Duchenne muscular dystrophy (DMD), implementation of mechanical ventilation depends on sleep investigation and measurement of CO2 tension. The objective of this cross-sectional study was to determine which noninvasive lung function parameter best predicts nocturnal hypercapnia and diurnal hypercapnia in these patients.
  
  
  METHODS
  According to transcutaneous CO2 (TcCO2) measurement, 114 DMD patients were classified into three groups: nocturnal hypercapnia (n = 38) [group N], diurnal hypercapnia (n = 39), despite nocturnal ventilation (group D), and 24-h normocapnia and spontaneous breathing (n = 37) [group S] as control. TcCO2 tension and lung function variables included vital capacity (VC) and maximal inspiratory pressure (MIP), and breathing pattern variables included tidal volume (Vt) and respiratory rate (RR), measured at the time of group inclusion. The rapid and shallow breathing index (RSBI [RR/Vt]) and Vt/VC ratio were calculated. Areas under the curve from the receiver operating characteristic (ROC) were calculated for those parameters.
  
  
  RESULTS
  Compared to group S, lung function was significantly worse in group N and group D. VC, RR, and RSBI distinguished group S from group N by ROC comparison. Cut-off values of VC < or = 680 mL (ROC, 0.968), MIP < or = 22 cm H2O (ROC, 0.928), and Vt/VC > 0.33 (ROC, 0.923) accurately discriminated group D from group N, but RSBI, RR, and Vt did not.
  
  
  CONCLUSIONS
  Lung function is useful to predict nocturnal hypercapnia in patients with DMD. Moreover, VC < 680 mL is very sensitive to predict daytime hypercapnia.
authors.affiliation: Inkendaal Rehabilitation Hospital, Neuromuscular Centre VUB-Inkendaal and Centre for Home Mechanical Ventilation, Inkendaalstraat, 1, B-1602 Vlezenbeek, Brussels, Belgium. michel.toussaint@inkendaal.be
authors.forename: Michel
authors.initials: M
authors.lastname: Toussaint
authors.forename: Marc
authors.initials: M
authors.lastname: Steens
authors.forename: Philippe
authors.initials: P
authors.lastname: Soudon
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D002940:Circadian Rhythm / Q000502:physiology; D003430:Cross-Sectional Studies; D006801:Humans; D006935:Hypercapnia / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy; D007385:Intermittent Positive-Pressure Ventilation; D020388:Muscular Dystrophy, Duchenne / Q000150:complications / Q000503:physiopathology* / Q000628:therapy; D011237:Predictive Value of Tests; D012372:ROC Curve; D012129:Respiratory Function Tests; D012890:Sleep / Q000502:physiology