Clinical, biochemical and ultrasonographic features of infertile women with polycystic ovarian syndrome.
OBJECTIVE
To evaluate and compare the clinical, biochemical and ultrasonic features of infertile women with PCOS from the two infertility centers of Karachi, The Aga Khan University Hospital and Concept Fertility Centre.


METHODS
Cross-sectional, analytical study.


METHODS
The Aga Khan University Hospital, and Concept Fertility Centre, Karachi, Pakistan, from January 2003 till December 2004.


METHODS
Patients attending the Infertility Clinics of Aga Khan University Hospital, Karachi and Concept Fertility Centre, Karachi, were evaluated for their clinical features. Complete biochemical evaluation was performed by day 2 FSH, LH, serum prolactin, serum testosterone and fasting serum insulin determination. These results were recorded on the data collection form. Ultrasonic evaluation was performed with transvaginal ultrasound to check the morphological appearance of ovaries.


RESULTS
A total of 508 patients were evaluated for epidemiological features of PCOS. Frequency of PCOS in the infertility clinic was 17.6% with high rate of obesity (68.5%) and hyperinsulinemia (59%). The highest rate of abnormal clinical, biochemical features were seen above BMI of 30.


CONCLUSIONS
High rates of obesity, hyperinsulinemia and impaired glycemic control were seen in this series. It was demonstrated that high BMI had an association and correlation with abnormal clinical and biochemical features. Obese women with PCOS need more attention for their appropriate management.
Haq
Fauzia
F
Department of Obstetrics & Gynaecology, Aga Khan University Hospital, Karachi, Pakistan.
Aftab
Omar
O
Rizvi
Javed
J
D000328:Adult; D015992:Body Mass Index; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D006946:Hyperinsulinism; D007247:Infertility, Female; D007986:Luteinizing Hormone / Q000097:blood; D009765:Obesity / Q000503:physiopathology; D010154:Pakistan / Q000453:epidemiology; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000000981:diagnostic imaging* / Q000453:epidemiology; D014463:Ultrasonography
D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone