title: Effect of Bio-Oss on osseointegration of dental implants surrounded by circumferential bone defects of different dimensions: an experimental study in the dog.
abstract: OBJECTIVE
  This study was designed to evaluate the effect of gap width and graft placement on bone healing around implants placed in simulated extraction sockets of various widths in four Labrador dogs.
  
  
  METHODS
  Five Osseotite implants per dog were placed in the mandible of four dogs. Two implants were inserted into sites with a 2.37 mm and two with a 1 mm gap present between the implants and bone around the coronal 6 mm of the implants in each dog. For one of each gap sizes, the gap was filled with Bio-Oss, and the other two with blood alone. A fifth implant was inserted without a gap and used as a control. Ground sections were prepared from biopsies taken at 4 months and histometric measurements of osseointegration and bone between the threads made for the coronal 6 mm.
  
  
  RESULTS
  The medians for osseointegration ranged from 5.2 mm for control to 1-2.6 mm for the test modalities. There were significant differences for linear measurements of osseointegration (chi(2) 18.27; df 4; P=0.0011) and bone area within threads (chi(2) 23.4; df 4; P=0.0001) between test modalities.
  
  
  CONCLUSIONS
  The results suggest that the wider the gap around the implants, the less favourable the histological outcome at short time intervals following treatment. They also infer that bone grafting with an organic bovine bone xenograft seems to lead to a more favourable histological outcome for wider circumferential defects but not for narrower defects.
authors.affiliation: Department of Periodontology, Dublin Dental Hospital, Dublin, Ireland.
authors.forename: Ioannis
authors.initials: I
authors.lastname: Polyzois
authors.forename: Stefan
authors.initials: S
authors.lastname: Renvert
authors.forename: Dieter D
authors.initials: DD
authors.lastname: Bosshardt
authors.forename: Niklaus P
authors.initials: NP
authors.lastname: Lang
authors.forename: Noel
authors.initials: N
authors.lastname: Claffey
mesh_terms: D000818:Animals; D018786:Bone Substitutes / Q000627:therapeutic use*; D016025:Bone Transplantation / Q000379:methods*; D003758:Dental Implantation, Endosseous / Q000379:methods; D004285:Dogs; D008903:Minerals / Q000627:therapeutic use*; D016348:Osseointegration / Q000187:drug effects*
chemical_list: C077540:Bio-Oss; D018786:Bone Substitutes; D008903:Minerals