An intrinsic host defense against HIV-1 integration?
HSCs are one of only a few cell types that resist HIV-1 infection despite the presence of HIV-1 receptors. An increasing number of genes have been identified that can reduce the sensitivity of cultured cells to retrovirus infection, and in this issue of the JCI, Zhang et al. identify p21(Waf1/Cip1/Sdi1) (p21) as a gene product that can influence the sensitivity of HSCs to HIV-1 infection (see the related article beginning on page 473). Strikingly, p21 appears to alter the fate of nuclear HIV-1 DNA, promoting the formation of circular viral DNA forms rather than functional proviruses.
Bieniasz
Paul D
PD
Aaron Diamond AIDS Research Center and Laboratory of Retrovirology, The Rockefeller University, New York, New York 10016, USA. pbienias@adarc.org
D050759:Cyclin-Dependent Kinase Inhibitor p21 / Q000235:genetics / Q000502:physiology; D004279:DNA, Viral / Q000378:metabolism; D015497:HIV-1 / Q000472:pathogenicity* / Q000502:physiology*; D006412:Hematopoietic Stem Cells / Q000502:physiology / Q000821:virology; D006801:Humans; D016662:Virus Integration / Q000502:physiology*; D014779:Virus Replication
C493956:CDKN1A protein, human; D050759:Cyclin-Dependent Kinase Inhibitor p21; D004279:DNA, Viral