Correlation in Lewy pathology between the claustrum and visual areas in brains of dementia with Lewy bodies.
We investigated Lewy pathologies in the claustrum and the related cerebral cortices and subcortical nuclei of dementia with Lewy bodies (DLB) brains using alpha-synuclein-immunohistochemistry to clarify the relationship between Lewy pathology in the claustrum and visual misidentification of DLB patients. The claustrum is known to have strong reciprocal connections with the visual areas. Consequently, the claustrum demonstrated many Lewy bodies (LB) and LB-related neurites. The insular and inferior temporal cortices, amygdala, BA 18, 19, transentohrinal and cingulate cortices showed stronger or similar Lewy pathology as compared with the claustrum, while BA 17, precentral, postcentral and transverse temporal cortices showed weaker Lewy pathology. Comparing the correlation coefficient of Lewy pathology between the clausturm and other regions, BA 18 and 19 as well as the insular and transentorhinal cortices demonstrated a higher correlation coefficient. These findings suggest that Lewy pathology in the claustrum is more closely associated with that in visual areas than in auditory, somatosensory or motor areas, and that dysfunction of the visuo-claustral pathway participates in visual misidentification in addition to the visuo-amygdaloid pathway. The paralimbic cortices including the insular and transentorhinal cortices may connect visual areas with limbic areas by relay of the visuo-claustral or visuo-amygdaloid pathway.
Yamamoto
Ryoko
R
Department of Psychiatry, Juntendo Tokyo Koto Geriatric Medical Center, Juntendo University School of Medicine, 3-3-20 Shinsuna, Koto-ku, Tokyo 136-0075, Japan.
Iseki
Eizo
E
Murayama
Norio
N
Minegishi
Michiko
M
Marui
Wami
W
Togo
Takashi
T
Katsuse
Omi
O
Kosaka
Kenji
K
Kato
Masanori
M
Iwatsubo
Takeshi
T
Arai
Heii
H
D000368:Aged; D000679:Amygdala / Q000473:pathology*; D001479:Basal Ganglia / Q000473:pathology*; D018728:Entorhinal Cortex / Q000473:pathology; D005260:Female; D006179:Gyrus Cinguli / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D016631:Lewy Bodies / Q000378:metabolism / Q000473:pathology; D020961:Lewy Body Disease / Q000473:pathology*; D008297:Male; D013702:Temporal Lobe / Q000473:pathology; D014793:Visual Cortex / Q000473:pathology*; D014795:Visual Pathways / Q000473:pathology*; D051844:alpha-Synuclein / Q000032:analysis / Q000378:metabolism
D051844:alpha-Synuclein