A novel HLA-A2 variant, A*9203, identified by sequence-based typing.
HLA-A*9203, found in Taiwan using sequence-based typing method, was identical to HLA-A*0207 in exon 3 but differed in exon 2 by five nucleotide substitutions at positions 240-282 corresponding to three amino acid changes at codons 62, 66 and 70. Since this substitution motif is also seen in A*11 and A*03, it is likely that a gene conversion event from A*11 or A*03 to a A*0207 backbone may have been the process used in generating HLA-A*9203.
Chu
C-C
CC
Transfusion Medicine Laboratory, Medical Research Department, Mackay Memorial Hospital, Taipei, Taiwan.
Lee
H-L
HL
Lin
M
M
D000595:Amino Acid Sequence; D019943:Amino Acid Substitution; D044466:Asian People / Q000235:genetics; D001483:Base Sequence; D015234:HLA-A Antigens / Q000235:genetics*; D015789:HLA-A2 Antigen / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D017422:Sequence Analysis, DNA; D013624:Taiwan
D015234:HLA-A Antigens; C519204:HLA-A*02:103 antigen; D015789:HLA-A2 Antigen