title: Trends in colorectal cancer survival in northern Denmark: 1985-2004.
abstract: OBJECTIVE
  The prognosis for colorectal cancer (CRC) is less favourable in Denmark than in neighbouring countries. To improve cancer treatment in Denmark, a National Cancer Plan was proposed in 2000. We conducted this population-based study to monitor recent trends in CRC survival and mortality in four Danish counties.
  
  
  METHODS
  We used hospital discharge registry data for the period January 1985-March 2004 in the counties of north Jutland, Ringkjøbing, Viborg and Aarhus. We computed crude survival and used Cox proportional hazards regression analysis to compare mortality over time, adjusted for age and gender. A total of 19,515 CRC patients were identified and linked with the Central Office of Civil Registration to ascertain survival through January 2005.
  
  
  RESULTS
  From 1985 to 2004, 1-year and 5-year survival improved both for patients with colon and rectal cancer. From 1995-1999 to 2000-2004, overall 1-year survival of 65% for colon cancer did not improve, and some age groups experienced a decreasing 1-year survival probability. For rectal cancer, overall 1-year survival increased from 71% in 1995-1999 to 74% in 2000-2004. Using 1985-1989 as reference period, 30-day mortality did not decrease after implementation of the National Cancer Plan in 2000, neither for patients with colon nor rectal cancer. However, 1-year mortality for patients with rectal cancer did decline after its implementation.
  
  
  CONCLUSIONS
  Survival and mortality from colon and rectal cancer improved before the National Cancer Plan was proposed; after its implementation, however, improvement has been observed for rectal cancer only.
authors.affiliation: Department of Clinical Epidemiology, Aarhus Hospital, Aarhus, Denmark. lene.h.iversen@dadlnet.dk
authors.forename: L H
authors.initials: LH
authors.lastname: Iversen
authors.forename: M
authors.initials: M
authors.lastname: Nørgaard
authors.forename: P
authors.initials: P
authors.lastname: Jepsen
authors.forename: J
authors.initials: J
authors.lastname: Jacobsen
authors.forename: M M
authors.initials: MM
authors.lastname: Christensen
authors.forename: P
authors.initials: P
authors.lastname: Gandrup
authors.forename: M R
authors.initials: MR
authors.lastname: Madsen
authors.forename: S
authors.initials: S
authors.lastname: Laurberg
authors.forename: P
authors.initials: P
authors.lastname: Wogelius
authors.forename: H T
authors.initials: HT
authors.lastname: Sørensen
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D015179:Colorectal Neoplasms / Q000175:diagnosis / Q000453:epidemiology / Q000401:mortality*; D003718:Denmark / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016016:Proportional Hazards Models; D012042:Registries; D012189:Retrospective Studies; D016019:Survival Analysis; D015996:Survival Rate / Q000639:trends*