title: Preliminary examination of progression of Alzheimer's disease in a rural Southern African American cohort.
abstract: African Americans are at significantly increased risk for the development of Alzheimer's disease (AD), yet are seriously underrepresented in research trials. Preliminary experiences on a large scale, multi-site, 5-year longitudinal trial investigating the psychometric expression and progression of AD targeting an aging Southern rural cohort of African Americans are reported. Sixty-five participants, ranging from asymptomatic to severely demented, underwent extensive individual diagnostic and psychometric evaluation. Results indicated that cultural factors strongly influenced the data. Recruitment with asymptomatic volunteers were found to have greater educational attainment than other participant groups. Psychomotor measures showed greater impairment in African Americans compared to Caucasians suggesting increased cerebrovascular burden. African Americans' performance on the Boston Naming Test and the Wechsler Test of Adult Reading tests were significantly different than performance of Caucasian groups. The findings demonstrated that a better understanding of sociocultural factors associated with AD in the African American population may facilitate the development of primary and secondary preventions, especially when considering the role of cerebrovascular comorbidity which is a modifiable risk factor.
authors.affiliation: Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, United States. wagnermt@musc.edu <wagnermt@musc.edu>
authors.forename: Mark T
authors.initials: MT
authors.lastname: Wagner
authors.forename: Joy H
authors.initials: JH
authors.lastname: Wymer
authors.forename: Noelle E
authors.initials: NE
authors.lastname: Carlozzi
authors.forename: David
authors.initials: D
authors.lastname: Bachman
authors.forename: Aljoeson
authors.initials: A
authors.lastname: Walker
authors.forename: Jacobo
authors.initials: J
authors.lastname: Mintzer
mesh_terms: D001741:Black or African American; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000503:physiopathology* / Q000523:psychology*; D003071:Cognition / Q000502:physiology; D015331:Cohort Studies; D018450:Disease Progression; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests / Q000706:statistics & numerical data; D012424:Rural Population; D012931:Social Environment; D044465:White People