title: [The role of small molecules in regulation of activity of cytoplasmatic dehydrogenases].
abstract: The influence of silistrong on the activity of erythrocyte cytoplasmatic dehydrogenases and also purified glyceraldehyde-3-phosphate dehydrogenase (GAPH) was studied. Silistrong and its biologically active components (ethanol and silimarine) were found to activate GAPDH, lactate dehydrogenase (LDH), alpha-glycerophosphate dehydrogenase (GPDH) both in lysates of erythrocytes and in isolated GAPDH. The compounds studied are able to protect these enzymes and also to restore their activity of enzymes modified by hydrogen peroxide. Maximal activity is a characteristic of silistrong.
authors.forename: F N
authors.initials: FN
authors.lastname: Gil'miiarova
authors.forename: V M
authors.initials: VM
authors.lastname: Radomskaia
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Miakisheva
authors.forename: G M
authors.initials: GM
authors.lastname: Baisheva
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Pervova
authors.forename: N V
authors.initials: NV
authors.lastname: Spiridonova
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism / Q000494:pharmacology; D002492:Central Nervous System Depressants / Q000378:metabolism / Q000494:pharmacology; D003593:Cytoplasm / Q000201:enzymology*; D004789:Enzyme Activation / Q000187:drug effects; D004912:Erythrocytes / Q000201:enzymology; D000431:Ethanol / Q000378:metabolism* / Q000494:pharmacology; D006861:Hydrogen Peroxide / Q000378:metabolism* / Q000494:pharmacology; D016877:Oxidants / Q000378:metabolism / Q000494:pharmacology; D010088:Oxidoreductases / Q000378:metabolism*; D011817:Rabbits; D012838:Silymarin / Q000378:metabolism* / Q000494:pharmacology
chemical_list: D000975:Antioxidants; D002492:Central Nervous System Depressants; D016877:Oxidants; D012838:Silymarin; D000431:Ethanol; D006861:Hydrogen Peroxide; D010088:Oxidoreductases