title: Dosimetric characterization of a novel intracavitary mold applicator for 192Ir high dose rate endorectal brachytherapy treatment.
abstract: The dosimetric properties of a novel intracavitary mold applicator for 192Ir high dose rate (HDR) endorectal cancer treatment have been investigated using Monte Carlo (MC) simulations and experimental methods. The 28 cm long applicator has a flexible structure made of silicone rubber for easy passage into cavities with deep-seated tumors. It consists of eight source catheters arranged around a central cavity for shielding insertion, and is compatible for use with an endocavitary balloon. A phase space model of the HDR source has been validated for dose calculations using the GEANT4 MC code. GAFCHROMIC EBT model film was used to measure dose distributions in water around shielded and unshielded applicators with two loading configurations, and to quantify the shielding effect of a balloon injected with an iodine solution (300 mg I/mL). The film calibration procedure was performed in water using an 192Ir HDR source. Ionization chamber measurements in a Lucite phantom show that placing a tungsten rod in the applicator attenuates the dose in the shielded region by up to 85%. Inserting the shielded applicator into a water-filled balloon pushes the neighboring tissues away from the radiation source, and the resulting geometric displacement reduces the dose by up to 53%; another 8% dose reduction can be achieved when the balloon is injected with an iodine solution. All experimental results agree with the GEANT4 calculations within measurement uncertainties.
authors.affiliation: Medical Physics Unit, McGill University, 1650 Cedar Avenue, Montreal, Quebec H3G 1A4, Canada.
authors.forename: Emily
authors.initials: E
authors.lastname: Poon
authors.forename: Brigitte
authors.initials: B
authors.lastname: Reniers
authors.forename: Slobodan
authors.initials: S
authors.lastname: Devic
authors.forename: Té
authors.initials: T
authors.lastname: Vuong
authors.forename: Frank
authors.initials: F
authors.lastname: Verhaegen
mesh_terms: D001918:Brachytherapy / Q000295:instrumentation* / Q000379:methods*; D002138:Calibration; D005373:Film Dosimetry / Q000379:methods*; D006801:Humans; D007455:Iodine / Q000737:chemistry; D007477:Ions; D007496:Iridium Radioisotopes / Q000627:therapeutic use*; D015233:Models, Statistical; D008962:Models, Theoretical; D009010:Monte Carlo Method; D019047:Phantoms, Imaging; D011874:Radiometry / Q000379:methods*; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods; D012004:Rectal Neoplasms / Q000532:radiotherapy*; D012828:Silicones / Q000737:chemistry; D014962:X-Ray Film
chemical_list: D007477:Ions; D007496:Iridium Radioisotopes; D012828:Silicones; D007455:Iodine