title: Interleukin-10 regulated gene expression in cells of hypothalamic-pituitary-adrenal axis origin.
abstract: OBJECTIVE
  The hypothalamic-pituitary-adrenal (HPA) axis is a mediator for interactions between the immune and neuroendocrine systems. Pro-inflammatory cytokines such as interleukin-1 (IL-1), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) have been shown to activate the HPA axis. Recently, interleukin-10, an important anti-inflammatory cytokine in the immune system, has been shown to be expressed in the central nervous system and neuroendocrine system. Little is known, however, about IL-10's functions in the HPA axis.
  
  
  METHODS
  The Affymetrix DNA microarray (mouse genome U74Av2 Probe Array) was conducted to determine the gene expression profile regulated by IL-10 in cells of HPA axis origin.
  
  
  RESULTS
  In this study, we analyzed gene expression regulated by IL-10 in cells derived from the HPA axis. The results showed that quorums of genes are modulated by IL-10 in these neuroendocrine cells.
  
  
  CONCLUSIONS
  These findings will provide a valuable repository to aid in understanding IL-10's functions in the HPA axis at the molecular level.
authors.affiliation: Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555-1019, USA.
authors.forename: Huolin
authors.initials: H
authors.lastname: Tu
authors.forename: Peter L
authors.initials: PL
authors.lastname: Rady
authors.forename: Terry
authors.initials: T
authors.lastname: Juelich
authors.forename: Stephen K
authors.initials: SK
authors.lastname: Tyring
authors.forename: Nina
authors.initials: N
authors.lastname: Koldzic-Zivanovic
authors.forename: Eric M
authors.initials: EM
authors.lastname: Smith
authors.forename: Thomas K
authors.initials: TK
authors.lastname: Hughes
mesh_terms: D000818:Animals; D002460:Cell Line; D005786:Gene Expression Regulation / Q000187:drug effects / Q000276:immunology; D023281:Genomics; D007030:Hypothalamo-Hypophyseal System / Q000166:cytology / Q000276:immunology*; D016753:Interleukin-10 / Q000494:pharmacology* / Q000502:physiology*; D051379:Mice; D009474:Neurons / Q000187:drug effects / Q000502:physiology; D020411:Oligonucleotide Array Sequence Analysis; D010913:Pituitary-Adrenal System / Q000166:cytology / Q000276:immunology*
chemical_list: D016753:Interleukin-10