Interleukin 7 requirement for survival of T-cell acute lymphoblastic leukemia and human thymocytes on bone marrow stroma.
We explored the role of interleukin-7 (IL-7) in the bone marrow (BM) stroma-mediated survival of primary T-cell acute lymphoblastic leukemia (T-ALL) cells and normal thymocytes. We presented evidence that IL-7 has a major role in the enhanced survival mediated by BM stroma both in T-ALL cells and thymocytes.
Scupoli
Maria T
MT
Perbellini
Omar
O
Krampera
Mauro
M
Vinante
Fabrizio
F
Cioffi
Federica
F
Pizzolo
Giovanni
G
D000818:Animals; D001854:Bone Marrow Cells / Q000166:cytology*; D049109:Cell Proliferation; D002470:Cell Survival; D002648:Child; D002675:Child, Preschool; D018920:Coculture Techniques; D005434:Flow Cytometry; D006801:Humans; D007223:Infant; D015851:Interleukin-7 / Q000096:biosynthesis / Q000502:physiology*; D038041:Lymphopoiesis; D051379:Mice; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000097:blood*; D013950:Thymus Gland / Q000166:cytology* / Q000378:metabolism
D015851:Interleukin-7