TRP channels as target sites for insecticides: physiology, pharmacology and toxicology.
Transient receptor potential (TRP) channels are attracting attention from various research areas including physiology, pharmacology and toxicology. Our group has focused on TRPA1 channels and revealed their expression pattern, ion channel kinetics and pharmacological characteristics. From Integrated Pest Management point of view, TRP channels could be a possible new target site of pest control agents as well as the primary or secondary target site for known insecticides. We have examined expressed TRPA1 channels using physiological and pharmacological methods to clarify the function of these channels. Here, we show that the TRPA1 is activated by the insecticide and natural toxin allyl isothiocyanate which is known as insecticide.
Nagata
Keiichi
K
Department of Anesthesiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. keiichi@northwestern.edu
D000818:Animals; D002118:Calcium / Q000494:pharmacology / Q000502:physiology; D015220:Calcium Channels / Q000187:drug effects / Q000502:physiology*; D002460:Cell Line; D006801:Humans; D007306:Insecticides / Q000633:toxicity*; D017879:Isothiocyanates / Q000494:pharmacology; D007668:Kidney; D009419:Nerve Tissue Proteins / Q000187:drug effects / Q000502:physiology*; D018408:Patch-Clamp Techniques; D011994:Recombinant Proteins / Q000378:metabolism; D000074025:TRPA1 Cation Channel; D050052:TRPC Cation Channels / Q000187:drug effects* / Q000502:physiology*; D014162:Transfection; D050051:Transient Receptor Potential Channels / Q000187:drug effects / Q000235:genetics / Q000502:physiology*
D015220:Calcium Channels; D007306:Insecticides; D017879:Isothiocyanates; D009419:Nerve Tissue Proteins; D011994:Recombinant Proteins; D000074025:TRPA1 Cation Channel; C473350:TRPA1 protein, human; D050052:TRPC Cation Channels; D050051:Transient Receptor Potential Channels; C004471:allyl isothiocyanate; D002118:Calcium