[Formulation and process optimization of formula Qiqi pellets prepared by extrusion-spheronization].
OBJECTIVE
To prepare traditional Chinese medicine formula Qiqi pellets by extrusion-spheronization and study the optimal formulation and process.


METHODS
Qiqi pellets were prepared by a new style extrusion-spheronization equipment, the optimal formulation and process was obtained by the studies of influenitial factors and L9 (3(4)) orthogonal design, the micromeritic properties and product yield of pellets were determined.


RESULTS
The formula Qiqi pellets prepared by extrusion-spheronization were all spheral with smooth surface; the product yield was high.


CONCLUSIONS
Extrusion-spheronization was suitable to produce Chinese Herbal Medicine pellets. The preparation process was simple and feasible; The quality of the prepared pellets was excellent. It was worth further study.
Chen
Hong-xia
HX
School of Pharmacy, Jiangsu University, Zhenjiang 212001, China. chhx2005@sohu.com
Jia
Xiao-bin
XB
Chen
Yan
Y
Pan
Guo-liang
GL
Cheng
Xu-dong
XD
D027885:Astragalus propinquus / Q000737:chemistry; D002482:Cellulose / Q000737:chemistry; D004338:Drug Combinations; D004339:Drug Compounding / Q000295:instrumentation / Q000379:methods; D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000302:isolation & purification; D000431:Ethanol / Q000737:chemistry; D032305:Lycium / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D013678:Technology, Pharmaceutical / Q000295:instrumentation / Q000379:methods*; D014867:Water / Q000737:chemistry
D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; C528246:qiqi; D014867:Water; D000431:Ethanol; D002482:Cellulose; C109691:microcrystalline cellulose