title: Fluoxetine, smoking, and history of major depression: A randomized controlled trial.
abstract: The study was a randomized placebo-controlled trial testing whether fluoxetine selectively enhances cessation for smokers with a history of depression. Euthymic smokers with (H+, n = 109) or without (H-, n = 138) a history of major depression received 60 mg fluoxetine or placebo plus group behavioral quit-smoking treatment for 12 weeks. Fluoxetine initially enhanced cessation for H+ smokers (p = .02) but subsequently impaired cessation regardless of depressive history. Six months after quit date, fluoxetine-treated participants were 3.3 times more likely to be smoking (p = .02). Further research is warranted to determine why high-dose fluoxetine produces continuing effects that oppose tobacco abstinence.
authors.affiliation: Psychology Department, University of Illinois at Chicago, Chicago, IL, USA. bspring@northwestern.edu
authors.forename: Bonnie
authors.initials: B
authors.lastname: Spring
authors.forename: Neal
authors.initials: N
authors.lastname: Doran
authors.forename: Sherry
authors.initials: S
authors.lastname: Pagoto
authors.forename: Dennis
authors.initials: D
authors.lastname: McChargue
authors.forename: Jessica Werth
authors.initials: JW
authors.lastname: Cook
authors.forename: Katherine
authors.initials: K
authors.lastname: Bailey
authors.forename: John
authors.initials: J
authors.lastname: Crayton
authors.forename: Donald
authors.initials: D
authors.lastname: Hedeker
mesh_terms: D000293:Adolescent; D000328:Adult; D003865:Major Depressive Disorder / Q000188:drug therapy / Q000453:epidemiology / Q000523:psychology; D005473:Fluoxetine / Q000627:therapeutic use*; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use*; D012907:Smoking / Q000453:epidemiology*; D011795:Surveys and Questionnaires
chemical_list: D005473:Fluoxetine; D017367:Selective Serotonin Reuptake Inhibitors