18FDG PET in hallucinating and non-hallucinating patients.
OBJECTIVE
The aim of the study was to detect whether the abnormal regional brain activity correlates with auditory verbal hallucination-proneness (AVH) in a group of patients with schizophrenia and schizophrenia-related psychoses.


METHODS
15 patients with prominent AVH (score for hallucination intensity--item 3 in the PANSS > or =4) and 15 control patients without AVH (item 3 PANSS score < or =2) underwent 18FDG positron emission tomography at rest.


RESULTS
SPM group analysis revealed an increased uptake of 18FDG in the right middle frontal gyrus (BA46) in subjects with high verbal hallucination score compared to non-hallucinating patients (p<0.001, uncorrected). Activation in BA46 positively correlated with the intensity of hallucinations (Spearman r=0.57; p<0.001).


CONCLUSIONS
The observed functional recruitment of the right prefrontal cortex in subjects with high hallucination score may reflect impairment in the integration of intended actions and sensory feedback resulting in misattribution of internal events to an external source. This mechanism may form the cognitive basis for AVH.
Kopecek
Miloslav
M
Prague Psychiatric Centre, 3rd Medical Faculty Prague--Charles University, Centre of Neuropsychiatric Studies in Prague, Prague, Czech Republic. kopecek@pcp.lf3.cuni.cz
Spaniel
Filip
F
Novák
Tomás
T
Tislerová
Barbora
B
Belohlávek
Otakar
O
Horácek
Jirí
J
D000328:Adult; D001931:Brain Mapping; D016022:Case-Control Studies; D003071:Cognition / Q000502:physiology; D005260:Female; D019788:Fluorodeoxyglucose F18; D006212:Hallucinations / Q000000981:diagnostic imaging* / Q000378:metabolism; D006801:Humans; D008297:Male; D049268:Positron-Emission Tomography; D017397:Prefrontal Cortex / Q000000981:diagnostic imaging* / Q000378:metabolism; D011618:Psychotic Disorders / Q000000981:diagnostic imaging / Q000378:metabolism; D019275:Radiopharmaceuticals; D012559:Schizophrenia / Q000000981:diagnostic imaging* / Q000378:metabolism
D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18