Finite-size domains in membranes with active two-state inclusions.
The distribution of inclusion-rich domains in membranes with active two-state inclusions is studied by simulations. Our study shows that typical size of inclusion-rich domains (L) can be controlled by inclusion activities in several ways. When there is effective attraction between state-1 inclusions, we find: (i) Small domains with only several inclusions are observed for inclusions with time scales (approximately 10(-3)s) and interaction energy [approximately Omicron(kBT)] comparable to motor proteins. (ii) L scales as 13 power of the lifetime of state-1 for a wide range of parameters. (iii) L shows a switch-like dependence on state-2 lifetime k12(-1). That is, L depends weakly on k12 when k12<k12* but increases rapidly with k12 when k12>k12*, the crossover k12* occurs when the diffusion length of a typical state-2 inclusion within its lifetime is comparable to L. (iv) Inclusion-curvature coupling provides another length scale that competes with the effects of transition rates.
Chen
Chien-Hsun
CH
Department of Physics, Center for Complex Systems, National Central University, Jhongli, 32054 Taiwan.
Chen
Hsuan-Yi
HY
D003198:Computer Simulation; D008051:Lipid Bilayers / Q000737:chemistry*; D008560:Membrane Fluidity; D021962:Membrane Microdomains / Q000737:chemistry*; D008565:Membrane Proteins / Q000737:chemistry* / Q000648:ultrastructure*; D008956:Models, Chemical; D008968:Molecular Conformation
D008051:Lipid Bilayers; D008565:Membrane Proteins