Effects of halofuginone on fibrosis formation secondary to experimentally induced subglottic trauma.
OBJECTIVE
The aim of the study was to assess the antifibrotic effect of systemically applied halofuginone after subglottic injury.


METHODS
After standardized trauma to subglottic area, rats were divided into two groups: a study group that received treatment and a control group that did not. The rats were treated with 0.1 mg/kg/day intraperitoneal halofuginone injection for 30 days. The larynx specimens were examined histopathologically under light microscope for epithelization, inflammation, necrosis, and fibrosis.


RESULTS
The fibrosis indexes of the treated group were significantly less than those of the control group (P < .01).


CONCLUSIONS
Systemically applied halofuginone hydrobromide decreases fibrosis/scar tissue formation secondary to experimentally induced acute subglottic trauma.
Ertuğrul
E Eylem
EE
ENT Department, GATA Haydarpasa Educational Hospital, Kadikoy, Istanbul. ertugrul@doctor.com
Cincik
Hakan
H
Dogru
Salim
S
Cekin
Engin
E
Berber
Ufuk
U
Gungor
Atila
A
Poyrazoğlu
I Ethem
IE
D000818:Animals; D002921:Cicatrix / Q000473:pathology / Q000517:prevention & control; D004848:Epithelium / Q000187:drug effects / Q000473:pathology; D005260:Female; D005355:Fibrosis; D005931:Glottis / Q000187:drug effects / Q000293:injuries / Q000473:pathology; D007274:Injections, Intraperitoneal; D007827:Laryngitis / Q000473:pathology; D007829:Laryngostenosis / Q000473:pathology / Q000517:prevention & control; D007830:Larynx / Q000187:drug effects / Q000293:injuries* / Q000473:pathology; D008297:Male; D009336:Necrosis; D010880:Piperidines / Q000008:administration & dosage / Q000627:therapeutic use*; D011500:Protein Synthesis Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use*; D052999:Quinazolinones / Q000008:administration & dosage / Q000627:therapeutic use*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley
D010880:Piperidines; D011500:Protein Synthesis Inhibitors; D052999:Quinazolinones; C010176:halofuginone