Vocal fold augmentation with calcium hydroxylapatite (CaHA).
OBJECTIVE
Evaluate the effectiveness of CaHA injection for patients with glottal incompetence.


METHODS
Multi-center, open-label, prospective clinical study with each patient serving as his/her own control. Voice-related outcome measures were collected for pre-injection and 1, 3, and 6 months.


RESULTS
Sixty-eight patients were available for evaluation. Fifty percent of the injection procedures were done in office. Fifty-seven percent were diagnosed with unilateral paralysis and 42% with glottal incompetence with mobile vocal folds. Patient satisfaction 6 months post showed 56% had significantly improved voice and 38% reported moderately improved voice. Paired t tests from baseline to 6 months showed significant improvements on the VHI and VAS (vocal effort), CAPE-V judgments of voice severity and videoendostroboscopy ratings of glottal closure, and objective voice measures of glottal closure (MPT and S:Z ratio).


CONCLUSIONS
Preliminary results in this large cohort of patients demonstrate excellent clinical results.
Rosen
Clark A
CA
University of Pittsburgh Dept. of Otolaryngology-HNS, University of Pittsburgh Voice Center, Pittsburgh, PA 15213, USA, and University Hospital of Louvain-Mont Goddine, Yvoir, Belgium. RosenCA@upmc.edu
Gartner-Schmidt
Jackie
J
Casiano
Roy
R
Anderson
Timothy D
TD
Johnson
Felicia
F
Reussner
Lee
L
Remacle
Marc
M
Sataloff
Robert T
RT
Abitbol
Jean
J
Shaw
Gary
G
Archer
Sanford
S
McWhorter
Andrew
A
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001672:Biocompatible Materials / Q000008:administration & dosage / Q000627:therapeutic use*; D017886:Durapatite / Q000008:administration & dosage / Q000627:therapeutic use*; D005931:Glottis; D006801:Humans; D007267:Injections; D008875:Middle Aged; D011446:Prospective Studies; D049489:Stroboscopy; D014826:Vocal Cord Paralysis / Q000628:therapy*; D014827:Vocal Cords
D001672:Biocompatible Materials; D017886:Durapatite