[The influence of electrical stimulation of the paleocerebellar cortex upon spike-wave activity induced at the early stage of corazol-induced kindling in rats].
Chronic Wistar rats experiments have shown that repeated administrations of corazol in subthreshold dosages (30.0 mg/kg, i.p.) were followed by spike-wave (SW) bursts of discharges. Duration of such bursts as well as common period of their registration were longer in the course of epileptogen administration. High-frequency (100 Hz0 electric stimulation of the paleocerebellar cortex decreased duration of SW-complexes and period of their registration while low-frequency (10 Hz) electric stimulation resulted in a short-term effect of reduction of duration of SW bursts.
Kobolev
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D000200:Action Potentials; D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects* / Q000502:physiology*; D003292:Convulsants / Q000494:pharmacology*; D004558:Electric Stimulation; D007696:Kindling, Neurologic; D008297:Male; D010433:Pentylenetetrazole / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D003292:Convulsants; D010433:Pentylenetetrazole