Severe photosensitivity causing multifocal squamous cell carcinomas secondary to prolonged voriconazole therapy.
A 32-year-old woman was treated with long-term voriconazole therapy for recurrent aspergillosis associated with chronic granulomatous disease. A short time after commencement of voriconazole therapy, a severe photosensitivity reaction developed. Continued voriconazole exposure led to the development of multifocal facial squamous cell carcinomas. The photosensitivity reaction resolved after the patient changed therapy to posaconazole.
McCarthy
Kate L
KL
Sullivan and Nicolaides Pathology, Princess Alexandra Hospital, Queensland, Australia. Kate_Mccarthy@snp.com.au
Playford
E Geoffrey
EG
Looke
David F M
DF
Whitby
Michael
M
D000328:Adult; D000935:Antifungal Agents / Q000009:adverse effects* / Q000627:therapeutic use; D002294:Carcinoma, Squamous Cell / Q000209:etiology*; D005260:Female; D006105:Granulomatous Disease, Chronic / Q000188:drug therapy; D006801:Humans; D010787:Photosensitivity Disorders / Q000139:chemically induced* / Q000175:diagnosis / Q000473:pathology; D011743:Pyrimidines / Q000009:adverse effects* / Q000627:therapeutic use; D012878:Skin Neoplasms / Q000209:etiology*; D014230:Triazoles / Q000009:adverse effects* / Q000627:therapeutic use; D065819:Voriconazole
D000935:Antifungal Agents; D011743:Pyrimidines; D014230:Triazoles; D065819:Voriconazole