title: Renal transplantation in dialysis patients with the history of coronary artery bypass grafting and cardiac valve replacement.
abstract: Death with a functioning kidney is the most frequent cause of graft failure. Cardiovascular disease is the most frequent cause of death after renal transplantation. Therefore, prior to grafting, it is mandatory to diagnose and treat coronary artery disease and heart valve impairment. Transplantation is the best option for renal replacement therapy as far as the quality of life and life expectancy are concerned, although patients with such comorbidities may experience a higher short-term mortality risk. The objective for this study was to analyze both short- and long-term results of patients after coronary artery bypass grafting (CABG) or cardiac valve replacement (CVR). The cardiac surgery recipient group (CSR) included 16 patients (15 men, 1 woman) aged from 44 to 73 (mean 54.9 +/- 7.8) years. CABG was performed in 13/16 patients, and CVR in 3/16. The rest of our patients were treated as a comparative noncardiac surgery recipient (non-CSR) group. It consisted of 422 patients (264 men, 158 women) aged from 14 to 68 years (mean 43.2 +/- 12.9). The comparison revealed that graft function estimated at 1 year after transplantation was not different: serum creatinine concentrations of 1.7 +/- 0.2 and 1.6 +/- 0.5 mg/dL in CSR and non-CSR, respectively. One-year patient survival in the CVR group of 93.8% was slightly worse than that in the non-CSR group (97.9%), but death-censored 1-year graft survivals were comparable in both groups (93.8% vs 92%). Urinary tract and cytomegalovirus infections were the most common complications in the CSR group. One patient lost his graft in month 3(rd) due to many serious infectious complications. One patient died at the end of 12 months as a result of a cardiovascular event (1/16). Our single-center results confirm that transplantation in patients after CABG or CVR is a safe procedure; therefore, such patients should be referred into the waiting list.
authors.affiliation: Medical University of Gdansk, Department of Nephrology, Transplantation, and Internal Medicine, Gdansk, Poland.
authors.forename: A
authors.initials: A
authors.lastname: Debska-Slizień
authors.forename: S
authors.initials: S
authors.lastname: Lizakowski
authors.forename: W
authors.initials: W
authors.lastname: Wołyniec
authors.forename: B
authors.initials: B
authors.lastname: Giergielewicz
authors.forename: D
authors.initials: D
authors.lastname: Zadrozny
authors.forename: A
authors.initials: A
authors.lastname: Milecka
authors.forename: G
authors.initials: G
authors.lastname: Moszkowska
authors.forename: M
authors.initials: M
authors.lastname: Dudziak
authors.forename: J
authors.initials: J
authors.lastname: Rogowski
authors.forename: Z
authors.initials: Z
authors.lastname: Sledziński
authors.forename: B
authors.initials: B
authors.lastname: Rutkowski
mesh_terms: D000328:Adult; D000368:Aged; D000465:Algorithms; D001026:Coronary Artery Bypass; D005260:Female; D019918:Heart Valve Prosthesis Implantation; D006650:Histocompatibility Testing; D006801:Humans; D007674:Kidney Diseases / Q000145:classification / Q000601:surgery / Q000628:therapy; D007676:Kidney Failure, Chronic / Q000601:surgery*; D016030:Kidney Transplantation / Q000502:physiology*; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome