Synthesis and biological activities of novel furo[2,3,4-jk][2]benzazepin-4(3H)-one derivatives.
A novel seven-membered lactam formation method has been established by intramolecular ring closure reaction of 4-bromo-(E)-3-[(2-alkylvinyl)carbonylamino]benzo[b]furans under Heck coupling conditions. A number of furo[2,3,4-jk][2]benzazepin-4(3H)-ones, tricyclicbenzo[b]furans, have been prepared by this method and evaluated for their leukotriene B(4) (LTB(4)) receptor and poly(ADP-ribose)polymerase-1 (PARP-1) inhibitory activities.
Ando
Kumiko
K
School of Pharmaceutical Sciences, Mukogawa Women's University, 11-68 Koshien Kyuban-cho, Nishinomiya 663-8179, Japan.
Akai
Yukiko
Y
Kunitomo
Jun-Ichi
J
Yokomizo
Takehiko
T
Nakajima
Hidemitsu
H
Takeuchi
Tadayoshi
T
Yamashita
Masayuki
M
Ohta
Shunsaku
S
Ohishi
Takahiro
T
Ohishi
Yoshitaka
Y
D000818:Animals; D001552:Benzazepines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001572:Benzofurans / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D016466:CHO Cells; D006224:Cricetinae; D003412:Cricetulus; D004789:Enzyme Activation / Q000187:drug effects; D006801:Humans; D015394:Molecular Structure; D000071137:Poly (ADP-Ribose) Polymerase-1; D000067856:Poly(ADP-ribose) Polymerase Inhibitors; D018102:Receptors, Leukotriene B4 / Q000037:antagonists & inhibitors; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D001552:Benzazepines; D001572:Benzofurans; D000067856:Poly(ADP-ribose) Polymerase Inhibitors; D018102:Receptors, Leukotriene B4; C499320:PARP1 protein, human; D000071137:Poly (ADP-Ribose) Polymerase-1