Influence of alcohols on the critical micelle concentration of heptacainium chloride. Study of local anesthetics, part 171.
The critical micelle concentrations (CMC), of heptacainium chloride in various 0.5 M alcohols (methanol, ethanol and n-propanol) were determined using spectrophotometric measurements. CMC values were determined through the change in the slope when the absorbance versus surfactant concentration was plotted at 234 nm. The CMC values show that micelle formation occurred more easily in methanol than in other higher alcohols.
Andriamainty
F
F
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Comenius University, Bratislava, Slovak Republic. mouanda@fpharm.uniba.sk
Cizmárik
J
J
Zúdorová
Z
Z
Malík
I
I
Sedlárová
E
E
D000438:Alcohols / Q000737:chemistry*; D000465:Algorithms; D000779:Anesthetics, Local / Q000737:chemistry*; D008823:Micelles; D010880:Piperidines / Q000737:chemistry*; D012997:Solvents; D013501:Surface-Active Agents / Q000737:chemistry; D013816:Thermodynamics
D000438:Alcohols; D000779:Anesthetics, Local; D008823:Micelles; D010880:Piperidines; D012997:Solvents; D013501:Surface-Active Agents; C013549:heptacaine