Magnesium intake and colorectal cancer risk in the Netherlands Cohort Study.
Energy-adjusted magnesium intake was nonsignificantly inversely related to risk of colorectal cancer (n=2328) in the Netherlands Cohort Study on Diet and Cancer that started in 1986 (n=58 279 men and 62 573 women). Statistically significant inverse trends in risk were observed in overweight subjects for colon and proximal colon cancer across increasing quintiles of magnesium uptake (P-trend, 0.05 and 0.02, respectively). Although an overall protective effect was not afforded, our results suggest an effect of magnesium in overweight subjects, possibly through decreasing insulin resistance.
van den Brandt
P A
PA
Department of Epidemiology, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands. PA.vandenBrandt@epid.unimass.nl
Smits
K M
KM
Goldbohm
R A
RA
Weijenberg
M P
MP
D000368:Aged; D015992:Body Mass Index; D015331:Cohort Studies; D015179:Colorectal Neoplasms / Q000517:prevention & control*; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D008274:Magnesium / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D009426:Netherlands
D008274:Magnesium