Prothrombotic coagulation abnormalities in patients with newly diagnosed multiple myeloma.
Prothrombotic coagulation abnormalities were analyzed in patients with untreated multiple myeloma. Increases in factor VIII, in von Willebrand factor (vWF) and a decrease in protein S were observed and these changes were strongly associated with disease stage. No difference in baseline coagulation parameters was found between patients with and without subsequent venous thromboembolism.
Auwerda
Johannes J A
JJ
Sonneveld
Pieter
P
de Maat
Monica P M
MP
Leebeek
Frank W G
FW
D000368:Aged; D017152:Antibodies, Antiphospholipid / Q000737:chemistry; D001777:Blood Coagulation; D001778:Blood Coagulation Disorders / Q000150:complications* / Q000175:diagnosis*; D016022:Case-Control Studies; D005169:Factor VIII / Q000096:biosynthesis; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000097:blood* / Q000175:diagnosis*; D017293:Protein S / Q000096:biosynthesis; D020246:Venous Thrombosis / Q000150:complications* / Q000175:diagnosis*; D014841:von Willebrand Factor / Q000096:biosynthesis
D017152:Antibodies, Antiphospholipid; D017293:Protein S; D014841:von Willebrand Factor; D005169:Factor VIII