title: Efficacy of once-daily esomeprazole treatment in patients with laryngopharyngeal reflux evaluated by 24-hour pH monitoring.
abstract: OBJECTIVE
  Laryngopharyngeal reflux (LPR) is generally treated with twice-daily proton-pump inhibitor (PPI) therapy. In this study, the efficacy of esomeprazole 40 mg once-daily together with lifestyle modifications was determined by repeated 24-hour pH monitoring.
  
  
  METHODS
  A prospective study. Forty-nine patients with suspected LPR underwent 24-hour pH monitoring. Twenty-seven of 49 patients with measurable abnormal proximal reflux reflected by a reflux area index (RAI)>6.3 were treated with esomeprazole 40 mg every day, and a second pH study was performed.
  
  
  RESULTS
  In 22 of 27 patients, everyday PPI treatment reduced the RAI. Four of 5 patients with no RAI reduction reported on symptomatic relief.
  
  
  CONCLUSIONS
  In a considerable number of patients with suspected LPR, pH monitoring reveals no abnormal proximal reflux. Esomeprazole 40 mg every day together with lifestyle modifications could reach adequate acid suppression in a large number of patients. Symptom improvement is also reported by patients without measurable effects of therapy.
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, Ludwig Maximilians University Munich, Munich, and Klinikum Stuttgard, Katharinenhospital, Germany. entdoc@gmx.net
authors.forename: Oliver
authors.initials: O
authors.lastname: Reichel
authors.forename: Jeanette
authors.initials: J
authors.lastname: Keller
authors.forename: Gerd
authors.initials: G
authors.lastname: Rasp
authors.forename: Hjalmar
authors.initials: H
authors.lastname: Hagedorn
authors.forename: Alexander
authors.initials: A
authors.lastname: Berghaus
mesh_terms: D000328:Adult; D000369:Aged, 80 and over; D004791:Enzyme Inhibitors / Q000627:therapeutic use*; D064098:Esomeprazole / Q000627:therapeutic use*; D005260:Female; D018662:Fundoplication; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007013:Hypopharynx; D008019:Life Style; D008297:Male; D008875:Middle Aged; D018670:Monitoring, Ambulatory; D010608:Pharyngeal Diseases / Q000188:drug therapy*
chemical_list: D004791:Enzyme Inhibitors; D064098:Esomeprazole