title: Cerium doping and stoichiometry control for biomedical use of La0.7Sr0.3MnO3 nanoparticles: microwave absorption and cytotoxicity study.
abstract: La0.7Sr0.3MnO3 nanoparticles doped with cerium (La0.7-xCe(x)Sr0.3MnO3 where 0 < or = x < or = 0.7) as well as the La(1-y)Sr(y)MnO3 nanoparticles with different values of y (La/Sr ratio) are evaluated for cytotoxicity and heating application. Considering hyperthermia as one of the possible application domains of such materials, the cytotoxicity studies were done on human skin carcinoma and human fibrosarcoma cell lines. All the samples showed the desired heating effect when subjected to high-frequency exposure at 2.45 GHz. Cytotoxicity studies revealed extremely low cytotoxicity in Ce-doped samples as well as in samples with a reduced La/Sr ratio. A maximum percentage cell viability on exposure to these nanoparticles was 95% and 85% for the two groups of samples, respectively, with a dose of 20 microg/mL for the x = 0.4 sample. The issues of dopant solubility and nonstoichiometry are discussed.
authors.affiliation: Nanobiotechnology Group, Agharkar Research Institute, Pune, India.
authors.forename: Sangeeta N
authors.initials: SN
authors.lastname: Kale
authors.forename: Sumit
authors.initials: S
authors.lastname: Arora
authors.forename: Kavita R
authors.initials: KR
authors.lastname: Bhayani
authors.forename: Kishore M
authors.initials: KM
authors.lastname: Paknikar
authors.forename: Mona
authors.initials: M
authors.lastname: Jani
authors.forename: Ulhas V
authors.initials: UV
authors.lastname: Wagh
authors.forename: Shailaja D
authors.initials: SD
authors.lastname: Kulkarni
authors.forename: Satish B
authors.initials: SB
authors.lastname: Ogale
mesh_terms: D045744:Cell Line, Tumor; D002470:Cell Survival; D002563:Cerium / Q000494:pharmacology*; D005334:Fever; D005354:Fibrosarcoma / Q000188:drug therapy; D006801:Humans; D007811:Lanthanum / Q000737:chemistry*; D017895:Manganese Compounds / Q000737:chemistry*; D008872:Microwaves; D050997:Nanomedicine / Q000379:methods*; D053758:Nanoparticles / Q000737:chemistry*; D049329:Nanostructures / Q000737:chemistry; D010087:Oxides / Q000737:chemistry*; D012878:Skin Neoplasms / Q000188:drug therapy; D013324:Strontium / Q000737:chemistry*
chemical_list: D017895:Manganese Compounds; D010087:Oxides; C494384:manganite; D002563:Cerium; C027424:manganese oxide; D007811:Lanthanum; D013324:Strontium