title: Evaluation of nitroalkenes as nitric oxide donors.
abstract: Chemiluminescence experiments demonstrate that simple nitroalkenes release low levels of nitric oxide. UV and EPR measurements suggest but cannot confirm direct NO release from nitroalkenes. Given the biological activity of nitrated unsaturated fatty acids, these results suggest the possible metabolic conversion of nitroalkenes to NO.
authors.affiliation: Department of Chemistry, Wake Forest University, Winston-Salem, NC 27109, USA.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Gorczynski
authors.forename: Jinming
authors.initials: J
authors.lastname: Huang
authors.forename: Heather
authors.initials: H
authors.lastname: Lee
authors.forename: S Bruce
authors.initials: SB
authors.lastname: King
mesh_terms: D000475:Alkenes / Q000138:chemical synthesis* / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D004305:Dose-Response Relationship, Drug; D015195:Drug Design; D004578:Electron Spin Resonance Spectroscopy; D049449:Luminescence; D008956:Models, Chemical; D008968:Molecular Conformation; D009569:Nitric Oxide / Q000737:chemistry; D020030:Nitric Oxide Donors; D009574:Nitro Compounds / Q000737:chemistry; D013056:Spectrophotometry, Ultraviolet; D013997:Time Factors
chemical_list: D000475:Alkenes; D020030:Nitric Oxide Donors; D009574:Nitro Compounds; D009569:Nitric Oxide