title: [Lung transplantation and the development of diabetes mellitus in adult patients with cystic fibrosis].
abstract: OBJECTIVE
  The prevalence of diabetes mellitus is higher in patients with cystic fibrosis than in the general population. Solid organ transplantation is a significant risk factor for diabetes mellitus, which has been linked to type of immunosuppression. The aim of this study was to analyze whether lung transplantation represents a significant risk factor for the onset of abnormal carbohydrate metabolism in cystic fibrosis, whether it affects severity of alterations, and whether there is a relation to type of immunosuppression.
  
  
  METHODS
  The following data were extracted retrospectively for 54 patients with cystic fibrosis: type of carbohydrate metabolism alteration and treatment received, whether or not transplantation took place, and type of immunosuppression used.
  
  
  RESULTS
  Twenty of the 54 patients (37%) underwent lung transplantation; 18 of them (89%) developed diabetes mellitus. Eight of the patients (24%) who did not receive a lung developed diabetes and 10 (29%) displayed carbohydrate intolerance (P< .01, chi(2) test). Insulin was administered to 36.3% of nontransplanted patients and 78.6% of transplanted patients. The influence of immunosuppressant used was analyzed in 15 patients. Nine out of 10 patients (90%) treated with cyclosporine and 4 out of 5 (80%) of those treated with tacrolimus developed diabetes mellitus. All received the same regimen of corticosteroid therapy.
  
  
  CONCLUSIONS
  For cystic fibrosis patients, lung trans-plantation is a significant risk factor for developing abnormal carbohydrate metabolism and it influences severity and treatment. No significant differences in the frequency of development of diabetes mellitus were found in relation to type of immunosuppression.
authors.affiliation: Servicio de Endocrinología y Nutrición, Hospital Universitario La Fe, Valencia, España.
authors.forename: María Soledad
authors.initials: MS
authors.lastname: Navas de Solís
authors.forename: Juan Francisco
authors.initials: JF
authors.lastname: Merino Torres
authors.forename: Isabel
authors.initials: I
authors.lastname: Mascarell Martínez
authors.forename: Francisco
authors.initials: F
authors.lastname: Piñón Sellés
mesh_terms: D000293:Adolescent; D000328:Adult; D003550:Cystic Fibrosis / Q000601:surgery*; D003920:Diabetes Mellitus / Q000453:epidemiology / Q000209:etiology*; D005260:Female; D006801:Humans; D016040:Lung Transplantation / Q000009:adverse effects*; D008297:Male; D012189:Retrospective Studies; D012307:Risk Factors