title: The role of simvastatin on postoperative peritoneal adhesion formation in an animal model.
abstract: OBJECTIVE
  The aim of this study is to show the effect of simvastatin on intra-abdominal adhesion formation.
  
  
  METHODS
  Adhesion formation was achieved by scratching the cecum and anterior abdominal wall following median laparotomy. Three different groups of 10 rats each were formed. In group I, 0.57 mg/kg/day simvastatin was injected intraperitoneally right after the operation and for 5 days thereafter. In group II, an equal dose of simvastatin to that used in group I was given via gavage. A physiological saline solution was given to group III for the same period of time. On the 6th and 14th day, blood samples were taken and peritoneal lavage was performed to measure the tissue-type plasminogen activator (t-PA) activity. Adhesions were graded via re-laparotomies on the 14th day after the first operation.
  
  
  RESULTS
  The adhesion scores were 1.40 +/- 0.22, 1.50 +/- 0.26, and 2.90 +/- 0.34 in groups I, II, and III, respectively (p = 0.007), and the score was higher in group III than in the other groups (p = 0.005, p = 0.011).
  
  
  CONCLUSIONS
  Intraperitoneal simvastatin application decreases adhesion formation by increasing the t-PA level in abdominal surgery.
authors.affiliation: Kartal Research and Education Hospital, Istanbul, Turkey. hasan.kucuk@sbkeah.gov.tr
authors.forename: Hasan Fehmi
authors.initials: HF
authors.lastname: Kucuk
authors.forename: Levent
authors.initials: L
authors.lastname: Kaptanoglu
authors.forename: Necmi
authors.initials: N
authors.lastname: Kurt
authors.forename: Huseyin
authors.initials: H
authors.lastname: Uzun
authors.forename: Mehmet
authors.initials: M
authors.lastname: Eser
authors.forename: Sadik
authors.initials: S
authors.lastname: Bingul
authors.forename: Oguzhan Aziz
authors.initials: OA
authors.lastname: Torlak
authors.forename: Huseyin
authors.initials: H
authors.lastname: Akyol
mesh_terms: D034861:Abdominal Wall / Q000601:surgery; D000818:Animals; D002432:Cecum / Q000601:surgery; D013505:Digestive System Surgical Procedures / Q000009:adverse effects*; D004195:Disease Models, Animal; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D008297:Male; D010529:Peritoneal Cavity / Q000601:surgery; D010533:Peritoneal Lavage; D011183:Postoperative Complications / Q000188:drug therapy / Q000517:prevention & control; D051381:Rats; D017208:Rats, Wistar; D019821:Simvastatin / Q000494:pharmacology*; D000267:Tissue Adhesions / Q000188:drug therapy* / Q000517:prevention & control*; D010959:Tissue Plasminogen Activator / Q000097:blood
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D019821:Simvastatin; D010959:Tissue Plasminogen Activator