title: Cognitive functioning and instrumental activities of daily living in late-life bipolar disorder.
abstract: OBJECTIVE
  The authors report on the relationship between cognitive functioning and instrumental activities of daily living (IADLs) in elderly, clinically euthymic adults with bipolar disorder.
  
  
  METHODS
  Twenty patients with bipolar disorder (age range: 61-86 years) were administered comprehensive neuropsychologic testing. Structured in-home performance-based assessments of IADLs were performed in 19 of these patients.
  
  
  RESULTS
  Relative to age-equated comparators, bipolar subjects performed worse in information-processing speed and executive functioning. IADL performance was strongly correlated with these cognitive domains.
  
  
  CONCLUSIONS
  In euthymic elderly patients with bipolar disorder, decrements in information processing speed and executive functioning characterize cognitive function and are associated with poorer IADL performance.
authors.affiliation: Advanced Center for Intervention and Services Research for Late-Life Disorders, Department of Psychiatry, Bipolar Disorder Center for Pennsylvanians, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
authors.forename: Ariel G
authors.initials: AG
authors.lastname: Gildengers
authors.forename: Meryl A
authors.initials: MA
authors.lastname: Butters
authors.forename: Denise
authors.initials: D
authors.lastname: Chisholm
authors.forename: Joan C
authors.initials: JC
authors.lastname: Rogers
authors.forename: Margo B
authors.initials: MB
authors.lastname: Holm
authors.forename: Rishi K
authors.initials: RK
authors.lastname: Bhalla
authors.forename: Karen
authors.initials: K
authors.lastname: Seligman
authors.forename: Mary Amanda
authors.initials: MA
authors.lastname: Dew
authors.forename: Charles F
authors.initials: CF
authors.lastname: Reynolds
authors.forename: David J
authors.initials: DJ
authors.lastname: Kupfer
authors.forename: Benoit H
authors.initials: BH
authors.lastname: Mulsant
mesh_terms: D000203:Activities of Daily Living / Q000145:classification / Q000523:psychology; D000368:Aged; D000369:Aged, 80 and over; D000927:Anticonvulsants / Q000627:therapeutic use; D018692:Antimanic Agents / Q000627:therapeutic use; D001714:Bipolar Disorder / Q000175:diagnosis* / Q000188:drug therapy / Q000523:psychology; D003072:Cognition Disorders / Q000175:diagnosis* / Q000523:psychology; D005260:Female; D006801:Humans; D016651:Lithium Carbonate / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests / Q000706:statistics & numerical data; D011594:Psychometrics / Q000706:statistics & numerical data; D014635:Valproic Acid / Q000627:therapeutic use
chemical_list: D000927:Anticonvulsants; D018692:Antimanic Agents; D016651:Lithium Carbonate; D014635:Valproic Acid