title: [Multi-center clinical study of the effect of silver nitrate ointment on the partial-thickness burn wounds].
abstract: OBJECTIVE
  To evaluate the therapeutic effect of silver nitrate ointment on partial-thickness burn wounds, and observe its side-effects.
  
  
  METHODS
  Multi-center, randomized, positive drug paralleled self-controlled trial was carried out. Eighty patients with superficial partial-thickness burns, and 40 with deep-partial thickness burns were randomized into AgNO3 group and SD-Ag group according to drug topically applied to the wounds. The wound healing time, wound healing rate and bacterial culture of the wound, the effect and safety of the drug, as well as drug irritation to the wounds were studied in these two groups.
  
  
  RESULTS
  For the patients with superficial partial-thickness burn wounds, the wound healing time in silver nitrate group was (9.5 +/- 2.7) days, which was obviously shorter than that in SD-Ag group [(10.8 +/- 3.4) days, P <0.01]. The wound healing rate in silver nitrate group on 7 post-burn day ( PBD) was (77.9 +/- 20.5)%, which was obviously higher than that in SD-Ag group [(67.3 +/- 22.6) %, P < 0.01]. For those with deep-partial thickness burn wounds, the wound healing time in silver nitrate group was (21.5 +/- 4.8) days, which was evidently shorter than that in SD-Ag group [(23.3 +/- 6.4) days, P <0.01]. The wound healing rate in silver nitrate group on 20 PBD was (86.6 +/- 15.9)%, which was evidently higher than that in SD-Ag group [(78.5 +/- 17.7)%, P < 0.01]. Silver nitrate ointment has the same antibacterial effect as 1% SD-Ag cream, but it was less painful when applied to the open wounds.
  
  
  CONCLUSIONS
  Silver nitrate ointment is an effective and safe medicament for the clinical management of partial-thickness burn wounds.
authors.affiliation: Department of Burns, Ruijing Hospital, Medical College of Shanghai Jiaotong University, Shanghai 200025, P. R. China.
authors.forename: Zhen-jiang
authors.initials: ZJ
authors.lastname: Liao
authors.forename: Jing-ning
authors.initials: JN
authors.lastname: Huan
authors.forename: Guo-zhong
authors.initials: GZ
authors.lastname: Lv
authors.forename: Yong-ming
authors.initials: YM
authors.lastname: Shou
authors.forename: Zhi-yong
authors.initials: ZY
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D000328:Adult; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use*; D002056:Burns / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009824:Ointments; D012835:Silver Nitrate / Q000627:therapeutic use*; D012837:Silver Sulfadiazine / Q000627:therapeutic use*; D014945:Wound Healing
chemical_list: D000891:Anti-Infective Agents, Local; D009824:Ointments; D012835:Silver Nitrate; D012837:Silver Sulfadiazine