title: [Evaluating the impact of the second generation reproductive function on the established selenium and iodine deficiency rat models].
abstract: OBJECTIVE
  To observe the affection of selenium and iodine deficiency on the reproductive function of male and female F2 rat with the established model.
  
  
  METHODS
  Artificial synthesize feeds was used in our research. The healthy SD rat ceased lactation were chosen and randomly divided into three groups of lower selenium, lower iodine and two elements deficiency group and then raised in divided cages. The reproductive test of three generation was taken after evaluating the stability of the model. Meanwhile the fertility impact on the male and female rats in F2 was studied by observing the changes on sperm morphology, serum biochemical indexes, testicle pathology, fertility indexes, embryo osteogenesis and the viscera development.
  
  
  RESULTS
  The animal models of lower selenium, lower iodine and the two elements deficiency were established successfully. The stability of three animal models was satisfied during the experiment of three generation reproduce test. Deficiency of selenium, iodine and both of them can all impact the reproductive function of male rats on its morphological index of sperm, biochemical index of sperm and morphological and pathological changes in testicle. They can also impact the reproductive function of female rats on the weight of the second generation of pregnant rats, the embryonic and organic development of the third generation.
  
  
  CONCLUSIONS
  Deficiency of selenium and iodine can all impact the reproductive function on F2 model rats.
authors.affiliation: Department of Public Health, School of Medicine of Xi'an Jiaotong University, Xi'an 710061, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Yu
authors.forename: Hong
authors.initials: H
authors.lastname: Yan
authors.forename: Rui-juan
authors.initials: RJ
authors.lastname: Zhang
authors.forename: Sen-ke
authors.initials: SK
authors.lastname: Hu
authors.forename: Min
authors.initials: M
authors.lastname: Su
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004822:Epididymis / Q000473:pathology; D005260:Female; D007455:Iodine / Q000172:deficiency*; D008297:Male; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012098:Reproduction / Q000502:physiology*; D012643:Selenium / Q000172:deficiency*; D013737:Testis / Q000473:pathology; D013739:Testosterone / Q000097:blood
chemical_list: D013739:Testosterone; D007455:Iodine; D012643:Selenium