title: Good players left on the sidelines: why some synaptic vesicles don't get in the game.
abstract: A key question in synaptic physiology is what determines the release probability of a synaptic vesicle. In this issue of Neuron, Wadel et al. shed UV light on this problem, finding that hard-to-release vesicles are too far from Ca2+ channels.
authors.affiliation: Oregon Hearing Research Center / Vollum Institute, Oregon Health and Science University, Portland, OR 97239, USA.
authors.forename: Gareth D
authors.initials: GD
authors.lastname: Price
authors.forename: Laurence O
authors.initials: LO
authors.lastname: Trussell
mesh_terms: D000818:Animals; D017729:Presynaptic Terminals; D013569:Synapses / Q000502:physiology*; D009435:Synaptic Transmission / Q000502:physiology*; D013572:Synaptic Vesicles / Q000502:physiology*