title: Association between the metabolic syndrome and chronic kidney disease in Chinese adults.
abstract: BACKGROUND
  The metabolic syndrome is a common risk factor for cardiovascular and chronic kidney disease (CKD) in Western populations. We examined the relationship between the metabolic syndrome and risk of CKD in Chinese adults.
  
  
  METHODS
  A cross-sectional survey was conducted in a nationally representative sample of 15 160 Chinese adults aged 35-74 years. The metabolic syndrome was defined as the presence of three or more of the following risk factors: elevated blood pressure, low high density lipoprotein (HDL)-cholesterol, high triglycerides, elevated plasma glucose and abdominal obesity. CKD was defined as an estimated glomerular filtration rate<60 ml/min/1.73 m2 and elevated serum creatinine was defined as >or=1.14 mg/dl in men and >or=0.97 mg/dl in women (>or=95th percentile of serum creatinine in Chinese men and women aged 35-44 years without hypertension or diabetes, respectively).
  
  
  RESULTS
  The multivariate-adjusted odds ratios [95% confidence interval (CI)] of CKD and elevated serum creatinine in participants with compared to those without the metabolic syndrome were 1.64 (1.16, 2.32) and 1.36 (1.07, 1.73), respectively. Compared to participants without any components of the metabolic syndrome, the multivariate-adjusted odds ratios (95% CI) of CKD were 1.51 (1.02, 2.23), 1.50 (0.97, 2.32), 2.13 (1.30, 3.50) and 2.72 (1.50, 4.93) for those with 1, 2, 3, and 4 or 5 components, respectively. The corresponding multivariate-adjusted odds ratios (95% CI) of elevated serum creatinine were 1.11 (0.88, 1.40), 1.39 (1.07, 2.04), 1.47 (1.06, 2.04) and 2.00 (1.32, 3.03), respectively.
  
  
  CONCLUSIONS
  These findings suggest that the metabolic syndrome might be an important risk factor for CKD in Chinese adults.
authors.affiliation: Department of Medicine, Tulane University School of Medicine, 1430 Tulane Avenue, SL-45, New Orleans, LA 70112, USA, and the Cardiovascular Institute and Fuwai Hospital, Beijing, China. jchen@tulane.edu
authors.forename: Jing
authors.initials: J
authors.lastname: Chen
authors.forename: Dongfeng
authors.initials: D
authors.lastname: Gu
authors.forename: Chung-Shiuan
authors.initials: CS
authors.lastname: Chen
authors.forename: Xigui
authors.initials: X
authors.lastname: Wu
authors.forename: L Lee
authors.initials: LL
authors.lastname: Hamm
authors.forename: Paul
authors.initials: P
authors.lastname: Muntner
authors.forename: Vecihi
authors.initials: V
authors.lastname: Batuman
authors.forename: Chien-Hung
authors.initials: CH
authors.lastname: Lee
authors.forename: Paul K
authors.initials: PK
authors.lastname: Whelton
authors.forename: Jiang
authors.initials: J
authors.lastname: He
mesh_terms: D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000502:physiology; D015992:Body Mass Index; D002681:China / Q000453:epidemiology; D002908:Chronic Disease; D003404:Creatinine / Q000097:blood; D003430:Cross-Sectional Studies; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007674:Kidney Diseases / Q000150:complications* / Q000453:epidemiology / Q000208:ethnology / Q000503:physiopathology; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications* / Q000453:epidemiology / Q000208:ethnology / Q000503:physiopathology*; D008875:Middle Aged; D015999:Multivariate Analysis; D009765:Obesity / Q000150:complications / Q000503:physiopathology; D016017:Odds Ratio; D012307:Risk Factors
chemical_list: D001786:Blood Glucose; D003404:Creatinine