title: The anti-emetic efficacy of maropitant (Cerenia) in the treatment of ongoing emesis caused by a wide range of underlying clinical aetiologies in canine patients in Europe.
abstract: OBJECTIVE
  The efficacy of maropitant (Cerenia; Pfizer Inc.) as an anti-emetic for use in dogs with ongoing emesis was evaluated in a two-phase multi-centric study conducted at veterinary clinics in France, Italy, Slovakia and the UK.
  
  
  METHODS
  In phase I, dogs with ongoing emesis were randomised in a 1:1 ratio to either maropitant (32 dogs) or metoclopramide (34 dogs). In phase II, dogs were randomised in a 2:1 ratio to maropitant (77 dogs) or metoclopramide (40 dogs). Maropitant was administered subcutaneously at 1 mg/kg/day for up to five days. Metoclopramide was administered as recommended on the product labels as licensed at 0.5 to 1 mg/kg/day subcutaneously or orally with the daily dose divided over two to three administrations per day for up to three to five days.
  
  
  RESULTS
  In phase I, 97 per cent of dogs treated with maropitant and 71 per cent of dogs treated with metoclopramide did not vomit after treatment (P<0.01). The mean number of emetic events after maropitant treatment was significantly reduced compared with that after metoclopramide treatment (P=0.01). In phase II, the occurrence of emesis was lower for maropitant during the first 24 hours (P<0.0001) and for each day thereafter.
  
  
  CONCLUSIONS
  A single daily dose of maropitant was more effective than metoclopramide administered two or three times daily in the treatment of emesis caused by various aetiologies in dogs.
authors.affiliation: Veterinary Medicine Research & Development, Pfizer Ltd, Sandwich, Kent CT13 9NJ, UK.
authors.forename: V A
authors.initials: VA
authors.lastname: de la Puente-Redondo
authors.forename: E M
authors.initials: EM
authors.lastname: Siedek
authors.forename: H A
authors.initials: HA
authors.lastname: Benchaoui
authors.forename: N
authors.initials: N
authors.lastname: Tilt
authors.forename: T G
authors.initials: TG
authors.lastname: Rowan
authors.forename: R G
authors.initials: RG
authors.lastname: Clemence
mesh_terms: D000818:Animals; D000932:Antiemetics / Q000008:administration & dosage / Q000627:therapeutic use*; D004283:Dog Diseases / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D004285:Dogs; D005060:Europe; D005260:Female; D008297:Male; D011812:Quinuclidines / Q000008:administration & dosage / Q000627:therapeutic use*; D016896:Treatment Outcome; D014839:Vomiting / Q000188:drug therapy / Q000662:veterinary*
chemical_list: D000932:Antiemetics; D011812:Quinuclidines; C518176:maropitant