Apolipoprotein E gene polymorphism and left ventricular function in Iranian patients with thalassemia major.
Left ventricular (LV) failure is the main cause of death in thalassemia. Iron overload in patients with thalassemia leads to the formation of oxygen free radicals. Of the various apolipoprotein E (apoE) alleles, apoE4 is the least efficient in conditions of oxidative stress in comparison with apoE2 and apoE3. Our results showed that apoE4 is a genetic risk factor for LV dysfunction in thalassemia.
Bazrgar
Masood
M
Karimi
Mehran
M
Peiravian
Farah
F
Fathzadeh
Mohsen
M
D000293:Adolescent; D000328:Adult; D053329:Apolipoprotein E2 / Q000235:genetics; D053318:Apolipoprotein E3 / Q000235:genetics; D053327:Apolipoprotein E4 / Q000235:genetics; D001057:Apolipoproteins E / Q000235:genetics*; D002648:Child; D005260:Female; D006801:Humans; D007492:Iran; D008297:Male; D011110:Polymorphism, Genetic; D012307:Risk Factors; D018487:Ventricular Dysfunction, Left / Q000175:diagnosis / Q000235:genetics*; D017086:beta-Thalassemia / Q000235:genetics*
D053329:Apolipoprotein E2; D053318:Apolipoprotein E3; D053327:Apolipoprotein E4; D001057:Apolipoproteins E