Ursolic acid: a potent inhibitor of superoxides produced in the cellular system.
Triterpenoids of ursane class: ursolic acid, ilelatifol D, corosolic acid and euscaphic acid were isolated for the first time from Leonurus cardiaca, a member of the family Lamiaceae. The isolated compounds were tested for their cell-based antiinflammatory potential by suppressing respiratory burst activity and superoxide scavenging property by using xanthine/xanthine oxidase system to produce superoxides in the cell-free system. Ursolic acid was found to be an excellent inhibitor for the superoxides produced in the cellular system, while the same was inactive in the superoxide scavenging activity in cell-free system.
Ali
Muhammad S
MS
HEJ Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan. shaiq303@hotmail.com
Ibrahim
Syed A
SA
Jalil
Saima
S
Choudhary
Muhammad I
MI
D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D016166:Free Radical Scavengers / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D019686:Lamiaceae / Q000737:chemistry; D015394:Molecular Structure; D009504:Neutrophils / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D016897:Respiratory Burst / Q000187:drug effects*; D013481:Superoxides / Q000037:antagonists & inhibitors* / Q000378:metabolism; D014315:Triterpenes / Q000737:chemistry / Q000494:pharmacology*; D014969:Xanthine Oxidase / Q000378:metabolism; D000097245:Ursolic Acid
D016166:Free Radical Scavengers; D013481:Superoxides; D014315:Triterpenes; D014969:Xanthine Oxidase; D000097245:Ursolic Acid; C007695:euscaphic acid; C113861:corosolic acid