title: Prevention of recurrent bacterial urinary tract infections by intravesical instillation of hyaluronic acid.
abstract: OBJECTIVE
  To evaluate the efficacy of vesical instillation of hyaluronic acid against recurrent urinary tract infections.
  
  
  METHODS
  Twenty women with a history of recurrent urinary tract infections each received 9 intravesical instillations of hyaluronic acid over 6 months. Their status was assessed prospectively over 47.6 weeks and compared with a retrospective review of patient charts covering 36.2+/-6.2 weeks.
  
  
  RESULTS
  The total numbers of urinary tract infections were 67 before and 10 after treatment (p<0.001). Thirteen patients (65%) were free of recurrences until the end of the study. One had a recurrence during treatment, and 6 (30%) during follow-up. The number of infections per year per patient was reduced from 4.99+/-0.92 to 0.56+/-0.82 (p<0.001). In women with recurrences, time to recurrence was 178.3+/-25.5 days, compared with 76.7+/-24.6 days before treatment (p<0.001).
  
  
  CONCLUSIONS
  Intravesical instillation of hyaluronic acid is effective in preventing recurrent urinary tract infections.
authors.affiliation: Medical University of Vienna, Department of Obstetrics and Gynecology, AKH, Vienna, Austria. markus.lipovac@meduniwien.ac.at
authors.forename: M
authors.initials: M
authors.lastname: Lipovac
authors.forename: C
authors.initials: C
authors.lastname: Kurz
authors.forename: F
authors.initials: F
authors.lastname: Reithmayr
authors.forename: H C
authors.initials: HC
authors.lastname: Verhoeven
authors.forename: J C
authors.initials: JC
authors.lastname: Huber
authors.forename: M
authors.initials: M
authors.lastname: Imhof
mesh_terms: D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000283:Administration, Intravesical; D000293:Adolescent; D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006820:Hyaluronic Acid / Q000627:therapeutic use*; D011446:Prospective Studies; D012189:Retrospective Studies; D055502:Secondary Prevention; D013997:Time Factors; D014552:Urinary Tract Infections / Q000517:prevention & control*
chemical_list: D000276:Adjuvants, Immunologic; D006820:Hyaluronic Acid