title: Analysis of genetic systems using experimental evolution and whole-genome sequencing.
abstract: The application of whole-genome sequencing to the study of microbial evolution promises to reveal the complex functional networks of mutations that underlie adaptation. A recent study of parallel evolution in populations of Escherichia coli shows how adaptation involves both functional changes to specific proteins as well as global changes in regulation.
authors.affiliation: Department of Systems Biology, Harvard Medical School, Longwood Avenue, Boston, MA 02115, USA.
authors.forename: Matthew
authors.initials: M
authors.lastname: Hegreness
authors.forename: Roy
authors.initials: R
authors.lastname: Kishony
mesh_terms: D000220:Adaptation, Biological; D005075:Biological Evolution; D016680:Genome, Bacterial / Q000235:genetics*; D017422:Sequence Analysis, DNA