[Influence of hydrocortisone and adrenaline against the background of mu- and delta-opiate receptors blockade on local immune response in mice].
In the induced phase of the immune response, the immunosuppressive effects of hydrocortisone and adrenaline were enhanced under mu- and delta-opiate receptor blockade. No changes were observed in the effects of hydrocortisone and adrenaline under mu- and delta-opiate receptor blockade in effector phase. In the induced phase of the immune response, selective agonists of mu- and delta-opiate receptors DAGO and DADLE enhanced antibody response, delayed-type hypersensitivity, and reduced the number of cells in the regional lymph node. Thus, our data suggest an equal role of mu- and delta-opiate receptors in regulation of expressiveness of local immune response.
Geĭn
S V
SV
Chizhova
E G
EG
Tendriakova
S P
SP
D000818:Animals; D001402:B-Lymphocytes / Q000187:drug effects; D004837:Epinephrine / Q000494:pharmacology*; D017707:Erythrocyte Transfusion; D004912:Erythrocytes / Q000276:immunology; D006854:Hydrocortisone / Q000494:pharmacology*; D007114:Immunization; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D008198:Lymph Nodes / Q000166:cytology / Q000276:immunology; D018655:Lymphocyte Count; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D017465:Receptors, Opioid, delta / Q000037:antagonists & inhibitors / Q000502:physiology*; D017450:Receptors, Opioid, mu / Q000037:antagonists & inhibitors / Q000502:physiology*
D007166:Immunosuppressive Agents; D017465:Receptors, Opioid, delta; D017450:Receptors, Opioid, mu; D006854:Hydrocortisone; D004837:Epinephrine