Zinc ribbon domain containing 1 protein: modulator of multidrug resistance, tumorigenesis and cell cycle.
Zinc ribbon domain containing 1 (ZNRD1) gene encoding a protein consisting of two zinc ribbon domains was recently cloned from the human HLA locus. So far, ZNRD1 has been found implicated in transcription regulation and might play potential roles in mediating several biological processes, including multidrug resistance, tumorigenesis and cell cycle. This article reviewed these recent findings and provided additional information to support the role of ZNRD1 gene as a novel candidate DNA damage repair related gene.
Hong
L
L
State Key Laboratory of Cancer Biology, Institute of Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi Province, China.
Chen
Z
Z
Zhang
X
X
Xia
L
L
Han
Z
Z
Lu
Y
Y
Jin
H
H
Song
J
J
Qiao
T
T
Fan
D
D
D000818:Animals; D002453:Cell Cycle / Q000502:physiology*; D002471:Cell Transformation, Neoplastic / Q000378:metabolism*; D004260:DNA Repair / Q000502:physiology*; D004268:DNA-Binding Proteins / Q000378:metabolism*; D018432:Drug Resistance, Multiple / Q000502:physiology*; D006801:Humans
D004268:DNA-Binding Proteins; C406241:POLR1H protein, human