title: High-resolution complementary spatial modulation of magnetization (CSPAMM) rat heart tagging on a 1.5 Tesla Clinical Magnetic Resonance System: a preliminary feasibility study.
abstract: The purpose of this study was to assess the feasibility of cardiac magnetic resonance (MR) tagging in rats on a standard clinical 1.5T MR system. Small animal models have been largely used as an experimental model in cardiovascular disease studies but mainly on high field systems (>4T) dedicated to research. Given the larger availability of routine clinical MR systems in centers with active cardiac research programs, it is of great interest to perform small animal imaging on whole-body MR systems of moderate field strength. The feasibility study was performed on 7 rats within 6 to 8 hours after myocardial infarction and 3 normal control rats. Myocardial strain was measured successfully in normal rats using the harmonic phase (ie, HARP) method, and a transmural gradient was demonstrated. In a rat model of acute occlusion/reperfusion, the myocardial circumferential strains were decreased, but the transmural strain gradient was preserved. This study demonstrated the feasibility of cardiac MR tagging in rats with a subendocardial resolution using a clinical 1.5T system.
authors.affiliation: Radiology Department, Geneva University Hospital, Geneva, Switzerland.
authors.forename: Marko K
authors.initials: MK
authors.lastname: Ivancevic
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Daire
authors.forename: Jean-Noel
authors.initials: JN
authors.lastname: Hyacinthe
authors.forename: Gerard
authors.initials: G
authors.lastname: Crelier
authors.forename: Sebastian
authors.initials: S
authors.lastname: Kozerke
authors.forename: Karin
authors.initials: K
authors.lastname: Montet-Abou
authors.forename: Idil
authors.initials: I
authors.lastname: Gunes-Tatar
authors.forename: Denis R
authors.initials: DR
authors.lastname: Morel
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Vallée
mesh_terms: D000818:Animals; D005240:Feasibility Studies; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000295:instrumentation*; D019028:Magnetic Resonance Imaging, Cine / Q000295:instrumentation* / Q000379:methods; D009203:Myocardial Infarction / Q000175:diagnosis* / Q000473:pathology; D009206:Myocardium / Q000473:pathology*; D019047:Phantoms, Imaging; D051381:Rats; D017207:Rats, Sprague-Dawley