Primary resistance of human immunodeficiency virus type 1 in a reference center in Recife, Pernambuco, Brazil.
To assess the prevalence of primary resistance of human immunodeficiency virus type 1 (HIV-1) to antiretrovirals, 84 patients chronically infected with HIV without prior antiretroviral treatment from Northeast Brazil were studied. Genotyping was performed using the ViroSeq Genotyping System. Thimidine analog mutations occurred in 3 (3.6%) patients. Accessory mutations related to NRTI occurred in 6 (7.1%) and related to PI in 67 (79.8%). Subtypes B (72.6%), F (22.6%), B/F 3 (3.6%), and C (1.2%) were detected. A low prevalence of major mutations related to NRTI in patients chronically infected by HIV was observed.
de Medeiros
Luzidalva Barbosa
LB
Hospital das Clínicas, Departamento de Medicina Clínica, Universidade Federal de Pernambuco, Cidade Universitária, Recife, PE, Brasil.
Lacerda
Heloísa Ramos
HR
Cavalcanti
Ana Maria Salustiano
AM
de Albuquerque
Maria de Fátima Pessoa Militão
Mde F
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D001938:Brazil; D002908:Chronic Disease; D024882:Drug Resistance, Viral / Q000235:genetics*; D005260:Female; D005838:Genotype; D015658:HIV Infections / Q000188:drug therapy / Q000821:virology*; D016333:HIV Protease / Q000235:genetics; D054303:HIV Reverse Transcriptase / Q000235:genetics; D015497:HIV-1 / Q000187:drug effects* / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D016133:Polymerase Chain Reaction; D013936:Thymidine / Q000235:genetics
D019380:Anti-HIV Agents; D054303:HIV Reverse Transcriptase; D016333:HIV Protease; D013936:Thymidine