Maternal serum C-reactive protein concentrations in early pregnancy and subsequent risk of preterm delivery.
OBJECTIVE
To examine the relation between maternal early pregnancy serum C-reactive protein (CRP) and preterm delivery (PTD).


METHODS
Women were recruited before 20 weeks gestation and were followed up until delivery. Maternal serum CRP was measured by competitive immunoassay. Logistic regression procedures were used to calculate adjusted odds ratio (OR) and 95% confidence intervals (95%CI).


RESULTS
Elevations in CRP concentrations were associated with the risk of PTD overall. After adjusting for confounding, the OR for highest quartile (> or = 7.5 vs. < 2.0 mg/L) of CRP was 2.04 (95%CI: 1.13-3.69). Stratified analyses indicated that elevated CRP was associated with an increased risk of spontaneous preterm labour (OR=2.15, 95%CI: 0.85-5.42), medically indicated preterm delivery (OR=3.29, 95%CI: 0.98-11.02), and very preterm delivery (OR=20.6, 95%CI: 2.53-168.03), but not with preterm premature rupture of membranes (OR=1.48, 95%CI: 0.56-3.86).


CONCLUSIONS
Elevated CRP concentrations in early pregnancy are associated with an increased risk of PTD, particularly medically indicated PTD and very PTD.
Lohsoonthorn
Vitool
V
Department of Preventive and Social Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. vitool@u.washington.edu
Qiu
Chunfang
C
Williams
Michelle A
MA
D000328:Adult; D002097:C-Reactive Protein / Q000378:metabolism*; D005260:Female; D005865:Gestational Age; D006801:Humans; D011247:Pregnancy; D011256:Pregnancy Outcome; D047928:Premature Birth / Q000097:blood* / Q000378:metabolism; D011446:Prospective Studies; D012959:Socioeconomic Factors
D002097:C-Reactive Protein