Granular cell atypical fibroxanthoma: report of two cases.
Two cases of an uncommon histopathological variant of atypical fibroxanthoma (AFX) are described. Even though both lesions presented as clinically conventional atypical fibroxanthoma, histopathology disclosed a neoplasm composed of cells with granular change that was negative for S100 staining, and showed prominent pleomorphism, severe nuclear atypia, and a high mitotic index. Degenerative change may explain the granular phenotype in these two cases of AFX. The differential diagnosis with primitive nonneural granular cell tumor is discussed.
Ríos-Martín
Juan José
JJ
Department of Pathology, Virgen Macarena University Hospital, Seville, Spain. jjrios@us.es
Delgado
Mario Díaz
MD
Moreno-Ramírez
David
D
García-Escudero
Antonio
A
González-Cámpora
Ricardo
R
D000369:Aged, 80 and over; D049109:Cell Proliferation; D003937:Diagnosis, Differential; D005350:Fibroma / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology*; D016586:Granular Cell Tumor / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D008297:Male; D010641:Phenotype; D009418:S100 Proteins / Q000378:metabolism; D012878:Skin Neoplasms / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology*; D014973:Xanthomatosis / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology*
D009418:S100 Proteins