Mice lacking CD21 and CD35 proteins mount effective immune responses against Borrelia burgdorferi infection.
CD21/35(-/-) mice, deficient in CD21 and CD35 (complement receptors 2 and 1, respectively), were infected with Borrelia burgdorferi to assess the role of these receptors in a chronic bacterial infection. Although CD21/35(-/-) mice on both C57BL/6 and BALB/c backgrounds produced less B. burgdorferi-specific antibodies than did wild-type mice, spirochete levels and arthritis severity were similar.
Jacobson
Amanda C
AC
Department of Pathology, University of Utah School of Medicine, 15 North Medical Drive East, Salt Lake City, UT 84112-5650, USA.
Ma
Ying
Y
Zachary
James F
JF
Weis
Janis J
JJ
Weis
John H
JH
D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood; D001170:Arthritis, Infectious / Q000382:microbiology; D025065:Borrelia burgdorferi / Q000276:immunology*; D015169:Colony Count, Microbial; D004195:Disease Models, Animal; D007596:Joints / Q000382:microbiology; D008193:Lyme Disease / Q000276:immunology* / Q000382:microbiology; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D017463:Receptors, Complement 3b / Q000172:deficiency*; D017464:Receptors, Complement 3d / Q000172:deficiency*
D000907:Antibodies, Bacterial; D017463:Receptors, Complement 3b; D017464:Receptors, Complement 3d