title: Warfarin-induced skin necrosis after open heart surgery due to protein S and C deficiency.
abstract: Warfarin-induced skin necrosis is the rare but potentially devastating complication of anticoagulant therapy and commonly occurs in previously undetected C- and S-protein deficient patients. Because routine preoperative examination does not include protein C and S level measurement, detection of these patients preoperatively is generally not possible, which increases the risk of occurrence of this important complication. In this report we present and discuss such a patient, who died from warfarin-induced skin necrosis after coronary artery bypass surgery.
authors.affiliation: Department of Cardiovascular Surgery, Gulhane Military Medical Academy, Etlik, Ankara, 06018, Turkey. bsavoz@yahoo.com
authors.forename: Bilgehan Savas
authors.initials: BS
authors.lastname: Oz
authors.forename: Fatih
authors.initials: F
authors.lastname: Asgun
authors.forename: Kursad
authors.initials: K
authors.lastname: Oz
authors.forename: Erkan
authors.initials: E
authors.lastname: Kuralay
authors.forename: Harun
authors.initials: H
authors.lastname: Tatar
mesh_terms: D000368:Aged; D000925:Anticoagulants / Q000009:adverse effects*; D015897:Comorbidity; D001026:Coronary Artery Bypass; D003331:Coronary Vessels / Q000601:surgery; D004691:Endarterectomy; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D017202:Myocardial Ischemia / Q000453:epidemiology / Q000601:surgery; D009336:Necrosis; D020151:Protein C Deficiency / Q000150:complications* / Q000453:epidemiology; D018455:Protein S Deficiency / Q000150:complications* / Q000453:epidemiology; D012867:Skin / Q000473:pathology*; D014859:Warfarin / Q000009:adverse effects*
chemical_list: D000925:Anticoagulants; D014859:Warfarin