title: VPMCD: variable interaction modeling approach for class discrimination in biological systems.
abstract: Data classification algorithms applied for class prediction in computational biology literature are data specific and have shown varying degrees of performance. Different classes cannot be distinguished solely based on interclass distances or decision boundaries. We propose that inter-relations among the features be exploited for separating observations into specific classes. A new variable predictive model based class discrimination (VPMCD) method is described here. Three well established and proven data sets of varying statistical and biological significance are utilized as benchmark. The performance of the new method is compared with advanced classification algorithms. The new method performs better during different tests and shows higher stability and robustness. The VPMCD is observed to be a potentially strong classification approach and can be effectively extended to other data mining applications involving biological systems.
authors.affiliation: Department of Chemical and Biomolecular Engineering, 4 Engineering Drive 4, National University of Singapore, Singapore.
authors.forename: Rao
authors.initials: R
authors.lastname: Raghuraj
authors.forename: Samavedham
authors.initials: S
authors.lastname: Lakshminarayanan
mesh_terms: D000465:Algorithms; D019295:Computational Biology; D003627:Data Interpretation, Statistical; D016208:Databases, Factual; D016002:Discriminant Analysis; D006801:Humans; D008954:Models, Biological; D015233:Models, Statistical; D015999:Multivariate Analysis