title: A new modification of anti-tubercular active molecules.
abstract: The connection of two active molecules across an easily released bridge as a new type of potentially active molecule has been studied. The synthesis is based on derivatives that originate from isonicotinoyl hydrazide, pyrazinamide, p-aminosalicylic acid (PAS), ethambutol, and ciprofloxacin. The lipophilicity, hydrolysis (stability of the compounds), and antituberculotic activity as well as the structure-lipophilicity and structure-activity relationships are discussed.
authors.affiliation: Department of Inorganic and Organic Chemistry, Faculty of Pharmacy, Charles University in Prague, Heyrovského 1203, 50005 Hradec Králové, Czech Republic. imramovsky@faf.cuni.cz
authors.forename: Ales
authors.initials: A
authors.lastname: Imramovský
authors.forename: Slovenko
authors.initials: S
authors.lastname: Polanc
authors.forename: Jarmila
authors.initials: J
authors.lastname: Vinsová
authors.forename: Marijan
authors.initials: M
authors.lastname: Kocevar
authors.forename: Josef
authors.initials: J
authors.lastname: Jampílek
authors.forename: Zuzana
authors.initials: Z
authors.lastname: Recková
authors.forename: Jarmila
authors.initials: J
authors.lastname: Kaustová
mesh_terms: D000995:Antitubercular Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002851:Chromatography, High Pressure Liquid; D006207:Half-Life; D007538:Isoniazid / Q000138:chemical synthesis / Q000494:pharmacology; D007700:Kinetics; D008055:Lipids / Q000737:chemistry; D008826:Microbial Sensitivity Tests; D009162:Mycobacterium avium / Q000187:drug effects; D019909:Mycobacterium kansasii / Q000187:drug effects; D011718:Pyrazinamide / Q000138:chemical synthesis / Q000494:pharmacology; D021281:Quantitative Structure-Activity Relationship
chemical_list: D000995:Antitubercular Agents; D008055:Lipids; D011718:Pyrazinamide; D007538:Isoniazid