Assessment of local angiogenesis and vascular endothelial growth factor in the patients with atrophic-erosive and reticular oral lichen planus.
OBJECTIVE
The objective of this study was to assess local angiogenesis and expression of VEGF in atrophic-erosive and reticular oral lichen planus (OLP).


METHODS
Microvessel density (MVD) and VEGF level in 30 OLP subjects and 7 matched controls were detected by immunohistochemistry and ELISA.


RESULTS
MVD and VEGF levels in whole OLP group were significantly elevated (P = .033, P < .0001, respectively), and there was a positive correlation between MVD and VEGF (correlation coefficient = 0.84, P < .0001). MVD in atrophic-erosive OLP was significantly higher than that in controls (P = .001) and reticular OLP (P = .042), and the expression of VEGF in both subgroups was significantly higher (P < .0001, P = .008, respectively) compared to control group.


CONCLUSIONS
These results indicated that angiogenesis and VEGF expression were closely correlated to the different clinical forms of OLP lesions, which may give new insights into the mechanisms and treatment strategy of OLP.
Tao
Xiaoan
X
Department of Oral Medicine, Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong, PR China.
Huang
Yulei
Y
Li
Ruyao
R
Qing
Ronghui
R
Ma
Li
L
Rhodus
Nelson L
NL
Cheng
Bin
B
D000328:Adult; D000704:Analysis of Variance; D018952:Antigens, CD34 / Q000032:analysis; D002196:Capillaries / Q000254:growth & development; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D017676:Lichen Planus, Oral / Q000378:metabolism* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa / Q000098:blood supply*; D009389:Neovascularization, Pathologic; D010865:Pilot Projects; D014059:Tongue / Q000098:blood supply; D042461:Vascular Endothelial Growth Factor A / Q000096:biosynthesis*
D018952:Antigens, CD34; D042461:Vascular Endothelial Growth Factor A