Antioxidant flavonoids and isoflavonoids from rhizomes of Iris pseudopumila.
Chromatographic separation of a methanolic extract from Iris pseudopumila rhizomes led to the isolation of two new natural compounds, irilone 4'-O-[beta-D-glucopyranosyl-(1-->6)-beta-D-glucopyranoside] and isoscutellarein 6-C-beta-D-glucopyranoside, along with 9 isoflavonoids and 4 flavonoids. Their structures were determined on the basis of spectroscopic evidence. Isolated compounds were evaluated for their antioxidant activity using the luminol-dependent chemiluminescence assay, with quercetin as a positive control. Irilone 4'-O-beta-D-glucopyranoside and kaempferol 3-O-[alpha-L-rhamnopyranosyl-(1-->6)-beta-D-glucopyranoside] showed significant antioxidant activity.
Rigano
Daniela
D
Department of Chemistry of Natural Products, University of Naples Federico II, Italy. drigano@unina.it
Formisano
Carmen
C
Grassia
Armando
A
Grassia
Gianluca
G
Perrone
Angela
A
Piacente
Sonia
S
Vuotto
Maria Luisa
ML
Senatore
Felice
F
D000975:Antioxidants / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D005419:Flavonoids / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D007498:Iris; D007529:Isoflavones / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D049449:Luminescence; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D027343:Rhizome
D000975:Antioxidants; D005419:Flavonoids; D007529:Isoflavones; D010936:Plant Extracts