High mobility group proteins of the plant HMGB family: dynamic chromatin modulators.
In plants, the chromosomal high mobility group (HMG) proteins of the HMGB family typically contain a central HMG-box DNA-binding domain that is flanked by a basic N-terminal and an acidic C-terminal domain. The HMGB proteins are abundant and highly mobile proteins in the cell nucleus that influence chromatin structure and enhance the accessibility of binding sites to regulatory factors. Due to their remarkable DNA bending activity, HMGB proteins can increase the structural flexibility of DNA, promoting the assembly of nucleoprotein complexes that control DNA-dependent processes including transcription. Therefore, members of the HMGB family act as versatile modulators of chromatin function.
Grasser
Klaus D
KD
Department of Life Sciences, Aalborg University, Sohngaardsholmsvej 49, DK-9000 Aalborg, Denmark. kdg@bio.aau.dk
Launholt
Dorte
D
Grasser
Marion
M
D002843:Chromatin / Q000378:metabolism*; D018744:DNA, Plant / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D015870:Gene Expression; D017343:Genes, Plant; D024002:HMGB Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D006657:Histones / Q000737:chemistry / Q000378:metabolism; D046911:Macromolecular Substances; D008954:Models, Biological; D008958:Models, Molecular; D009698:Nucleoproteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D010802:Phylogeny; D010940:Plant Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D010944:Plants / Q000235:genetics / Q000378:metabolism; D011499:Protein Processing, Post-Translational; D017434:Protein Structure, Tertiary; D013347:Subcellular Fractions / Q000378:metabolism
D002843:Chromatin; D018744:DNA, Plant; D024002:HMGB Proteins; D006657:Histones; D046911:Macromolecular Substances; D009698:Nucleoproteins; D010940:Plant Proteins