F-16438s, novel binding inhibitors of CD44 and hyaluronic acid. II. Producing organism, fermentation, isolation, physico-chemical properties and structural elucidation.
In the course of our screening for binding inhibitors of CD44 and hyaluronic acid, five active compounds, F-16438 A, B, E, F and G were found and isolated from the cultured broth of a fungal strain, Gloeoporus dichrous SANK 30502. The structures of these compounds except for F-16438 G were elucidated by physico-chemical and spectral data to be new compounds related to caloporoside; F-16438 G was identified to be the 6'-malonylated derivative of caloporoside.
Hirota-Takahata
Yuki
Y
Core Technology Research Laboratories, Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan.
Harada
Hosami
H
Tanaka
Isshin
I
Nakata
Tomoko
T
Nakajima
Mutsuo
M
Takahashi
Masaaki
M
D005285:Fermentation; D018960:Hyaluronan Receptors / Q000378:metabolism*; D006820:Hyaluronic Acid / Q000037:antagonists & inhibitors* / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D008362:Mannosides / Q000737:chemistry / Q000302:isolation & purification*; D008968:Molecular Conformation; D020072:Polyporales / Q000378:metabolism*; D012459:Salicylates / Q000737:chemistry / Q000302:isolation & purification*
D018960:Hyaluronan Receptors; D008362:Mannosides; D012459:Salicylates; D006820:Hyaluronic Acid