Painful posttraumatic trigeminal neuropathy: a case report of relief with topiramate.
A case of chronic neuropathic pain in the infraorbital region following an untreated displaced zygomatic fracture is presented. The case responded favorably to topiramate and sensory testing revealed signs of nerve damage that remained unchanged over the follow-up period (six months) parallel to an analgesic effect. The clinical pharmacology of topiramate, which is reviewed, includes enhanced neuronal stability and neuroprotection, making it a possible candidate in the treatment of painful orofacial neuropathies.
Benoliel
Rafael
R
Dept. of Oral Medicine, The Hebrew University, Hadassah Faculty of Dental Medicine, P.O.B. 12272, Jerusalem 91120, Israel. benoliel@cc.huji.ac.il
Sharav
Yair
Y
Eliav
Eli
E
D018712:Analgesics, Non-Narcotic / Q000627:therapeutic use*; D000927:Anticonvulsants / Q000627:therapeutic use*; D005157:Facial Pain / Q000188:drug therapy* / Q000209:etiology; D005260:Female; D005632:Fructose / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006801:Humans; D008875:Middle Aged; D009915:Orbit / Q000294:innervation; D010147:Pain Measurement; D012684:Sensory Thresholds; D000077236:Topiramate; D020433:Trigeminal Nerve Diseases / Q000188:drug therapy* / Q000209:etiology*; D015051:Zygomatic Fractures / Q000150:complications*
D018712:Analgesics, Non-Narcotic; D000927:Anticonvulsants; D000077236:Topiramate; D005632:Fructose