myo-Inositol monophosphatase: a challenging target for mood stabilising drugs.
myo-Inositol monophosphatase has long been a target for drug discovery. Recent work has given detailed insight into its mechanism and dynamics plus new activities and some novel series of inhibitors. The goal of a bio-available inhibitor for this enzyme, however, remains a major challenge for medicinal chemistry.
Miller
D J
DJ
School of Chemistry, Main Building, Cardiff University, Park Place, Cardiff CF10 3AT, UK.
Allemann
R K
RK
D004789:Enzyme Activation / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D008670:Metals / Q000378:metabolism; D010744:Phosphoric Monoester Hydrolases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D011619:Psychotropic Drugs / Q000737:chemistry* / Q000494:pharmacology*; D015398:Signal Transduction
D004791:Enzyme Inhibitors; D008670:Metals; D011619:Psychotropic Drugs; D010744:Phosphoric Monoester Hydrolases; C021822:myo-inositol-1 (or 4)-monophosphatase