title: The impact of thyroid activity variations on some oxidizing-stress parameters in rats.
abstract: The effect of the thyroid activity on the formation of lipid peroxidation and on liver and heart antioxidant enzyme activities was investigated in Wistar rats. Hypothyroidism and hyperthyroidism conditions were induced for five weeks by the administration of 0.05% benzythiouracile (BTU) and L-thyroxine sodium salt (0.0012%), in drinking water, respectively. No significant effect was observed on the rates of both lipid peroxidation and the vitamin E in hepatic and cardiac tissues of hypothyroidism rats compared to the controls, contrary to the hyperthyroidism rats, which expressed a pronounced increase. The increased glutathione peroxidase activity in rats suffering from hyperthyroidism was associated with a fall of the reduced glutathione in the homogenate and a marked increase in the glutathione reductase activity. An increase in superoxide dismutase and catalase activities was also recorded in hyperthyroidism. Our results explain the thyroid activity variation in relation to the lipid peroxidation and the tissular contents of the enzymatic and the non-enzymatic antioxidants. To conclude, our results show the occurrence of a state of oxidizing stress in relation to hyperthyroidism.
authors.affiliation: Animal Ecophysiology Laboratory, Science Faculty, Badji Mokhtar University, Annaba, Algeria.
authors.forename: Mahfoud
authors.initials: M
authors.lastname: Messarah
authors.forename: Mohamed Salah
authors.initials: MS
authors.lastname: Boulakoud
authors.forename: Amel
authors.initials: A
authors.lastname: Boumendjel
authors.forename: Cherif
authors.initials: C
authors.lastname: Abdennour
authors.forename: Abdelfattah
authors.initials: A
authors.lastname: El Feki
mesh_terms: D000818:Animals; D001835:Body Weight; D002374:Catalase / Q000032:analysis; D005978:Glutathione / Q000032:analysis; D005979:Glutathione Peroxidase / Q000032:analysis; D005980:Glutathione Reductase / Q000032:analysis; D006980:Hyperthyroidism / Q000139:chemically induced / Q000378:metabolism*; D007037:Hypothyroidism / Q000139:chemically induced / Q000378:metabolism*; D015227:Lipid Peroxidation; D008099:Liver / Q000378:metabolism; D008297:Male; D009206:Myocardium / Q000378:metabolism; D018384:Oxidative Stress / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000032:analysis; D013889:Thiouracil / Q000031:analogs & derivatives / Q000633:toxicity; D013961:Thyroid Gland / Q000502:physiology*; D013974:Thyroxine / Q000633:toxicity
chemical_list: D013889:Thiouracil; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005980:Glutathione Reductase; D005978:Glutathione; C019269:benzylthiouracil; D013974:Thyroxine