Antimicrobial activities of some tetrahydronaphthalene-benzimidazole derivatives.
Novel retinoid derivatives containing a benzimidazole moiety were synthesized and tested for their antimicrobial activity. Their antimicrobial activities against methicillin-resistant Staphylococcus aureus (MRSA), Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Enterococcus faecalis, Candida krusei and Candida albicans were evaluated. While some of the compounds exhibited moderate activity against MRSA, S. aureus, E. faecalis, C. krusei and C. albicans, none of the compounds showed activity against E. coli and P. aeruginosa.
Ates-Alagoz
Zeynep
Z
Department of Pharmaceutical Chemistry, Ankara University, Faculty of Pharmacy, Tandoğan, Ankara, Turkey. zates@pharmacy.ankara.edu.tr
Yildiz
Sulhiye
S
Buyukbingol
Erdem
E
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000935:Antifungal Agents / Q000494:pharmacology*; D001562:Benzimidazoles / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects / Q000254:growth & development; D013293:Enterococcus faecalis / Q000187:drug effects / Q000254:growth & development; D004926:Escherichia coli / Q000187:drug effects / Q000254:growth & development; D016106:Methicillin Resistance; D008826:Microbial Sensitivity Tests; D011550:Pseudomonas aeruginosa / Q000187:drug effects / Q000254:growth & development; D012176:Retinoids / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects / Q000254:growth & development; D013764:Tetrahydronaphthalenes / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D001562:Benzimidazoles; D012176:Retinoids; D013764:Tetrahydronaphthalenes