Genome-wide scan for blood pressure in Australian and Dutch subjects suggests linkage at 5P, 14Q, and 17P.
Large-scale studies estimate the heritability of blood pressure at approximately 50%. We carried out a genome-wide linkage analysis to search for chromosomal loci that might explain this heritability using longitudinal, multiple measures of systolic and diastolic blood pressure obtained in sibling pairs and dizygotic twin pairs from 2 countries (a total of 286 pairs from Australia and 636 pairs from the Netherlands). These pairs and a large number of their parents were genotyped with microsatellite markers. Multivariate linkage analysis of the combined data of both countries, using a variance components approach, showed suggestive linkage for diastolic blood pressure on chromosomes 5p13.1 (logarithm of odds score: 2.48), 14q12 (logarithm of odds score: 2.40) and 17q24.3 (logarithm of odds score: 2.36). The highest logarithm of odds score of 1.21 for systolic blood pressure was observed on chromosome 13q34. These results replicate earlier findings and add to a slowly emerging picture of multiple loci contributing to quantitative blood pressure variation.
Hottenga
Jouke-Jan
JJ
Department of Biological Psychology and the Center for Neurogenomics and Clinical Research, Vrije Universiteit, Amsterdam, The Netherlands. jj.hottenga@psy.vu.nl
Whitfield
John B
JB
Posthuma
Danielle
D
Willemsen
Gonneke
G
de Geus
Eco J C
EJ
Martin
Nicholas G
NG
Boomsma
Dorret I
DI
D000328:Adult; D001315:Australia; D001794:Blood Pressure / Q000235:genetics*; D002874:Chromosome Mapping; D002883:Chromosomes, Human, Pair 14; D002886:Chromosomes, Human, Pair 17; D002895:Chromosomes, Human, Pair 5; D003971:Diastole; D005260:Female; D008040:Genetic Linkage; D015894:Genome, Human; D005838:Genotype; D006801:Humans; D008126:Lod Score; D008137:Longitudinal Studies; D008297:Male; D018895:Microsatellite Repeats; D008875:Middle Aged; D009426:Netherlands; D035781:Siblings; D013599:Systole; D014429:Twins, Dizygotic / Q000235:genetics; D014430:Twins, Monozygotic; D044465:White People / Q000235:genetics*