title: Type III collagen mimetic peptides designed with anti- or pro-aggregant activities on human platelets.
abstract: We report the synthesis of collagen related peptides containing the peptide sequence Lys-Hyp-Gly-Glu-Hyp-Gly-Pro-Lys. The alpha-triple helix peptides behave as type III collagen analogues supporting platelet aggregation, while the homotrimer which does not exhibit a triple-helical conformation inhibits type III collagen-induced human platelet aggregation. The incorporation of the octapeptide sequence in type III collagen mimetic peptides may lead to the loss of the anti-thrombotic activity for a pro-thrombotic one.
authors.affiliation: EA 3901, DMAG, Université de Picardie Jules Verne, UFR de Médecine et de Pharmacie, Amiens, France.
authors.forename: Viviane
authors.initials: V
authors.lastname: Pires
authors.forename: Julien
authors.initials: J
authors.lastname: Pêcher
authors.forename: Sophie
authors.initials: S
authors.lastname: Da Nascimento
authors.forename: Pascal
authors.initials: P
authors.lastname: Maurice
authors.forename: Arnaud
authors.initials: A
authors.lastname: Bonnefoy
authors.forename: Alexandra
authors.initials: A
authors.lastname: Dassonville
authors.forename: Carole
authors.initials: C
authors.lastname: Amant
authors.forename: Françoise
authors.initials: F
authors.lastname: Fauvel-Lafève
authors.forename: Chantal
authors.initials: C
authors.lastname: Legrand
authors.forename: Jacques
authors.initials: J
authors.lastname: Rochette
authors.forename: Pascal
authors.initials: P
authors.lastname: Sonnet
mesh_terms: D000595:Amino Acid Sequence; D002942:Circular Dichroism; D024061:Collagen Type III / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D018716:Molecular Mimicry; D008969:Molecular Sequence Data; D019906:Nuclear Magnetic Resonance, Biomolecular; D010974:Platelet Aggregation / Q000187:drug effects*; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: D024061:Collagen Type III