Industrial utilization of tin-initiated resorbable polymers: synthesis on a large scale with a low amount of initiator residue.
This article presents the successful large-batch synthesis of a resorbable polymer with a minimal amount of residual tin. Ring-opening polymerization of epsilon-caprolactone was performed in toluene, with a tin (IV) alkoxide as the initiator. A number of parameters were varied in order to study the polymerization with respect to the purity of solvent, batch size, and the residual amount of tin in the polymers. The synthesis of epsilon-caprolactone in undistilled toluene with 1-di-n-butyl-1-stanna-2,5-dioxacyclopentane as the initiator was successfully performed in batches of 5, 20, and 50 g with no differences in the final conversion, molecular weight, or molecular-weight distribution. The residual amount of tin was significantly reduced from over 1000 to 23 ppm. This study examines the industrial utility of the materials regarding the size and purity of the synthesis.
Stjerndahl
Anna
A
Department of Fibre and Polymer Technology, Royal Institute of Technology, SE-100 44 Stockholm, Sweden.
Wistrand
Anna Finne
AF
Albertsson
Ann-Christine
AC
D001672:Biocompatible Materials / Q000737:chemistry*; D007221:Industry; D007700:Kinetics; D046911:Macromolecular Substances / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008422:Materials Testing; D008956:Models, Chemical; D015394:Molecular Structure; D011108:Polymers / Q000737:chemistry*; D012997:Solvents / Q000737:chemistry; D013997:Time Factors; D014001:Tin / Q000737:chemistry / Q000494:pharmacology*; D014050:Toluene / Q000737:chemistry
D001672:Biocompatible Materials; D046911:Macromolecular Substances; D011108:Polymers; D012997:Solvents; D014050:Toluene; D014001:Tin