title: Macrophages in rheumatoid arthritis.
abstract: In rheumatoid arthritis (RA) tissue macrophages release growth factors, matrix metalloproteinases, cytokines, and chemokines. While in normal joints there is a balance between proinflammatory and anti-inflammatory cytokines, an imbalance between these inducers and inhibitors of inflammation occurs in RA, where macrophages are responsible for inducing inflammation, matrix destruction and angiogenesis.
authors.affiliation: University of Foggia Medical School, Foggia, Italy.
authors.forename: N
authors.initials: N
authors.lastname: Maruotti
authors.forename: F P
authors.initials: FP
authors.lastname: Cantatore
authors.forename: E
authors.initials: E
authors.lastname: Crivellato
authors.forename: A
authors.initials: A
authors.lastname: Vacca
authors.forename: D
authors.initials: D
authors.lastname: Ribatti
mesh_terms: D000818:Animals; D001172:Arthritis, Rheumatoid / Q000378:metabolism*; D018925:Chemokines / Q000378:metabolism; D016207:Cytokines / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D008264:Macrophages / Q000378:metabolism*; D045726:Metalloproteases / Q000378:metabolism; D009389:Neovascularization, Pathologic / Q000378:metabolism
chemical_list: D018925:Chemokines; D016207:Cytokines; D045726:Metalloproteases