Triple-helix mediated excimer and exciplex formation.
The synthesis and properties of triple-helical hybrids containing non-nucleosidic polyaromatic building blocks are described. Clamp-type oligonucleotides containing a non-nucleosidic pyrene linker form stable triple helices with a polypurine target strand containing a terminal pyrene or phenanthrene moiety. Stacking interactions between the unnatural building blocks enhance triplex stability and lead to strong excimer or exciplex formation, which is monitored by fluorescence spectroscopy.
Trkulja
Ivan
I
Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, CH-3012 Bern, Switzerland.
Häner
Robert
R
D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D009841:Oligonucleotides / Q000737:chemistry*; D010616:Phenanthrenes / Q000737:chemistry; D011721:Pyrenes / Q000737:chemistry; D013050:Spectrometry, Fluorescence
D009841:Oligonucleotides; D010616:Phenanthrenes; D011721:Pyrenes; C031181:phenanthrene; C030984:pyrene