[A clinical analysis of early stage infection after auto peripheral blood stem cell transplantation].
OBJECTIVE
To analyze the incidence, risk factors, treatment and prognosis of early stage infection after auto peripheral blood stem cell transplantation (APBSCT).


METHODS
The clinical data of 120 patients receiving APBSCT were analyzed.


RESULTS
The incidence rate of infection was 57.5% (69/120), with most of them (68/69) bacterial in origin. 2.5% (3/120) the patients died of infection. The first infection was usually observed on the 6th day after APBSCT and lasted for a median of 2 (1 - 23) days. Positive blood culture was found in 16.0% (11/69) of the patients, with all of them G(-) bacteria. Patients with age more than 45 years and not receiving CD(34)(+) sorting had higher infection rate. 61.8% (42/68) of the patients responded to treatment for the first infection within 48 hours.


CONCLUSIONS
The early stage infection rate after APBSCT is 57.5%, with most of them bacterial in origin. Most of the infections respond to broad-spectrum antibiotics. Patients with age more than 45 years and not receiving CD(34)(+) sorting have higher infection rate.
Duan
Ming-hui
MH
Department of Hematology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China. mhduan@sina.com
Zhou
Dao-bin
DB
Wang
Shu-jie
SJ
Han
Bing
B
Zhao
Yong-qiang
YQ
Shen
Ti
T
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D001424:Bacterial Infections / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D036102:Peripheral Blood Stem Cell Transplantation / Q000009:adverse effects*; D011379:Prognosis; D012189:Retrospective Studies; D014182:Transplantation, Autologous