title: The efficacy of non-surgical and systemic antibiotic treatment on smoking and non-smoking periodontitis patients.
abstract: In 28 adult severe periodontitis patients who did not respond to conventional periodontal therapy, full mouth clinical parameters including probing pocket depth, relative attachment level, bleeding on probing and suppuration after probing, visible plaque index and modified gingival index were recorded at the baseline and 14 months after treatment. Based on clinical and bacteriological diagnosis, a combination of systemic amoxicillin 500 mg x 3 and metronidazole 200 mg x 2 was prescribed for 7 days. In combination with non-surgical treatment, systemic antibiotic therapy, significantly improved median values of probing pocket depth, bleeding on probing, suppuration index, visible plaque index and modified gingival index except relative attachment level. Despite the improvement of clinical parameters in general, both bleeding on probing and suppuration index had significantly lower reduction in smokers than in non-smokers.
authors.affiliation: University of Tartu, Faculty of Medicine, Department of Stomatology, 6 Raekoja plats, 51003, Estonia. enerp@hot.ee
authors.forename: Ene-Renate
authors.initials: ER
authors.lastname: Pahkla
authors.forename: Taive
authors.initials: T
authors.lastname: Koppel
authors.forename: Paul
authors.initials: P
authors.lastname: Naaber
authors.forename: Mare
authors.initials: M
authors.lastname: Saag
authors.forename: Krista
authors.initials: K
authors.lastname: Loivukene
mesh_terms: D000328:Adult; D000368:Aged; D000658:Amoxicillin / Q000627:therapeutic use*; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D003774:Dental Plaque Index; D006801:Humans; D008137:Longitudinal Studies; D008795:Metronidazole / Q000627:therapeutic use*; D008875:Middle Aged; D010512:Periodontal Index; D010514:Periodontal Pocket / Q000188:drug therapy; D010518:Periodontitis / Q000188:drug therapy*; D012907:Smoking / Q000009:adverse effects
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D008795:Metronidazole; D000658:Amoxicillin