Lytic and latent antigens of the human gammaherpesviruses Kaposi's sarcoma-associated herpesvirus and Epstein-Barr virus induce T-cell responses with similar functional properties and memory phenotypes.
The cellular immunity against Kaposi's sarcoma-associated herpesvirus (KSHV) is poorly characterized and has not been compared to T-cell responses against other human herpesviruses. Here, novel and dominant targets of KSHV-specific cellular immunity are identified and compared to T cells specific for lytic and latent antigens in a second human gammaherpesvirus, Epstein-Barr virus. The data identify a novel HLA-B57- and HLA-B58-restricted epitope in the Orf57 protein and show consistently close parallels in immune phenotypes and functional response patterns between cells targeting lytic or latent KSHV- and EBV-encoded antigens, suggesting common mechanisms in the induction of these responses.
Bihl
Florian
F
Partners AIDS Research Center, Massachusetts General Hospital East, 149 13th Street, Charlestown, MA 02129-2000, USA.
Narayan
Murli
M
Chisholm
John V
JV
Henry
Leah M
LM
Suscovich
Todd J
TJ
Brown
Elizabeth E
EE
Welzel
Tania M
TM
Kaufmann
Daniel E
DE
Zaman
Tauheed M
TM
Dollard
Sheila
S
Martin
Jeff N
JN
Wang
Fred
F
Scadden
David T
DT
Kaye
Kenneth M
KM
Brander
Christian
C
D000956:Antigens, Viral / Q000276:immunology*; D000939:Epitopes / Q000235:genetics; D004854:Herpesvirus 4, Human / Q000276:immunology*; D019288:Herpesvirus 8, Human / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular / Q000276:immunology*; D007156:Immunologic Memory / Q000276:immunology; D016130:Immunophenotyping; D013601:T-Lymphocytes / Q000276:immunology* / Q000821:virology; D014764:Viral Proteins / Q000235:genetics
D000956:Antigens, Viral; D000939:Epitopes; D014764:Viral Proteins