Radiosurgery in epilepsy--pathological considerations.
Radiosurgery is being investigated as an alternative to open surgical resection for patients with medial temporal lobe epilepsy. Additionally, the biological effects of mesial temporal radiosurgery are being evaluated using several animal models. The mechanisms through which radiosurgery exerts antiepileptic effects have not yet been proven, but time and dose dependency have been repeatedly demonstrated. Thus, there is a need to carefully examine the histological changes in patients who have undergone radiosurgical treatment of epilepsy.
House
Paul A
PA
Department of Neurosurgery, University of Utah, Salt Lake City, Utah, USA.
Kim
Jung H
JH
Lanerolle
Nihal De
N
Barbaro
Nicholas M
NM
D000328:Adult; D004827:Epilepsy / Q000473:pathology* / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D016634:Radiosurgery / Q000379:methods*