title: Bone marrow findings in multicentric Castleman disease in HIV-negative patients.
abstract: Because bone marrow histology in multicentric Castleman disease in human immunodeficiency virus-negative patients is not well reported, we investigated sequential bone marrow biopsies of 3 affected human immunodeficiency virus-negative patients, of which one was human herpes virus 8 (HHV8)-positive. The histologic evaluation of the bone marrow revealed lymphoid follicles with regressed germinal centers in 1 patient. Another patient showed tumorlike but bland polyclonal plasmacytosis with large perivascular plasma cell clusters. The HHV8-positive patient revealed interstitial HHV8-positive cells accompanied by a mild plasmacytosis. The atypical lymphoid follicles could be regarded as a bone marrow manifestation of multicentric Castleman disease, whereas the plasmacytosis most likely is the result of excess interleukin 6 production. The presence of HHV8-positive cells within the bone marrow may indicate the dissemination of the virus in a compromised immune system.
authors.affiliation: Institut für Pathologie, Klinikum der Johannes Gutenberg Universität, Langenbeckstr. 1, 55101 Mainz, Germany. kreft@pathologie.klinik.uni-mainz.de
authors.forename: Andreas
authors.initials: A
authors.lastname: Kreft
authors.forename: Achim
authors.initials: A
authors.lastname: Weber
authors.forename: Erik
authors.initials: E
authors.lastname: Springer
authors.forename: Georg
authors.initials: G
authors.lastname: Hess
authors.forename: Charles James
authors.initials: CJ
authors.lastname: Kirkpatrick
mesh_terms: D000328:Adult; D000368:Aged; D000956:Antigens, Viral / Q000032:analysis; D001853:Bone Marrow / Q000276:immunology / Q000473:pathology* / Q000821:virology; D001854:Bone Marrow Cells / Q000276:immunology / Q000473:pathology* / Q000821:virology; D005871:Castleman Disease / Q000276:immunology / Q000473:pathology* / Q000821:virology; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D018858:Germinal Center / Q000473:pathology; D018023:HIV Seronegativity; D006566:Herpesviridae Infections / Q000150:complications / Q000276:immunology / Q000473:pathology; D019288:Herpesvirus 8, Human / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification; D006801:Humans; D008198:Lymph Nodes / Q000276:immunology / Q000473:pathology / Q000821:virology; D008297:Male; D008875:Middle Aged
chemical_list: D000956:Antigens, Viral; D004279:DNA, Viral