title: Phosphatidylinositol 3-kinase (PI3K) signaling and regulation of the antibody response.
abstract: The humoral immune response is characterized by the early secretion of IgM antibodies followed by the generation of IgG, IgA or IgE antibodies as a result of class switch recombination. In recent years, progress had been made in understanding the molecular events of CSR as well as transcriptional control of B cell differentiation into germinal center or antibody secreting cells. However, the biochemical signals downstream of cell surface receptors that regulate CSR during B cell differentiation remain ill-defined. We have recently identified PI3K as a critical regulator of both antibody secreting cell formation and class switch recombination. How PI3K activity may be regulating CSR during antigen-driven B cell differentiation and its potential contribution to humoral immunodeficiencies will be discussed.
authors.affiliation: Program of Inflammatory Disease Research, Infectious and Inflammatory Disease Center, Burnham Institute for Medical Research, La Jolla, California 92037, USA.
authors.forename: Sidne A
authors.initials: SA
authors.lastname: Omori
authors.forename: Robert C
authors.initials: RC
authors.lastname: Rickert
mesh_terms: D000818:Animals; D000917:Antibody Formation / Q000502:physiology*; D001402:B-Lymphocytes / Q000166:cytology / Q000201:enzymology* / Q000276:immunology*; D002454:Cell Differentiation; D018858:Germinal Center / Q000166:cytology / Q000201:enzymology / Q000276:immunology; D006801:Humans; D007154:Immune System Diseases / Q000378:metabolism; D017578:Immunoglobulin Class Switching; D007075:Immunoglobulin M / Q000276:immunology; D051379:Mice; D018448:Models, Immunological; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism*; D010950:Plasma Cells / Q000166:cytology / Q000201:enzymology / Q000276:immunology; D015398:Signal Transduction
chemical_list: D007075:Immunoglobulin M; D019869:Phosphatidylinositol 3-Kinases