title: Amorphane sesquiterpenes from a marine Streptomyces sp.
abstract: The chemical investigation of the crude extract of the marine-derived Streptomyces sp. M491 yielded three new sesquiterpenes, namely, 10alpha,11-dihydroxyamorph-4-ene (4), 10alpha,15-dihydroxyamorph-4-en-3-one (6), and 5alpha,10alpha,11-trihydroxyamorphan-3-one (7). In addition, the known compounds 10alpha-hydroxyamorph-4-en-3-one (2), o-hydroxyacetanilide, genistein, prunetin, and indole-3-carbaldehyde and the macrolide antibiotic chalcomycin A were identified. The structures were determined on the basis of spectroscopic analysis, especially 1D and 2D NMR data. This is the first report of these sesquiterpenes from bacteria.
authors.affiliation: Department of Organic and Biomolecular Chemistry, University of Göttingen, Tammannstrasse 2, D-37077 Göttingen, Germany.
authors.forename: Shao Jie
authors.initials: SJ
authors.lastname: Wu
authors.forename: Serge
authors.initials: S
authors.lastname: Fotso
authors.forename: Fuchao
authors.initials: F
authors.lastname: Li
authors.forename: Song
authors.initials: S
authors.lastname: Qin
authors.forename: Hartmut
authors.initials: H
authors.lastname: Laatsch
mesh_terms: D001419:Bacteria / Q000187:drug effects; D002681:China; D005658:Fungi / Q000187:drug effects; D008386:Marine Biology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D013302:Streptomyces / Q000737:chemistry*
chemical_list: D012717:Sesquiterpenes