title: First molecular surveillance report of HIV type 1 in injecting drug users and female sex workers along the U.S.-Mexico border.
abstract: HIV prevalence is increasing among high-risk populations in the Mexican-U.S. border cities of Tijuana and Ciudad Juarez. In 2005, the molecular epidemiology of HIV-1 was studied among injecting drug users (IDU) and female sex workers (FSW) in these cities, which are corridors for over two-thirds of the migrant flow between Mexico and the United States. Eleven samples (eight IDU and three FSW) were successfully amplified, sequenced, and analyzed. The results revealed that all 11 samples were subtype B. There was no phylogenetic clustering or separation of the strains between IDU and FSW or between Tijuana and Ciudad Juarez nor was the Mexican strain phylogenetically distinct from other subtype B strains. Two of three drug naive FSWs had low-level HIV-1 resistance mutations. This community-based study demonstrated that HIV-positive IDUs and FSWs in Ciudad Juarez and Tijuana were predominantly infected with subtype B. Further prevalence studies on HIV-1 resistance mutations among FSWs in these border cities are warranted.
authors.affiliation: Division of Epidemiology, Institute of Human Virology, University of Maryland Biotechnology Institute, Baltimore, MD 21201, USA.
authors.forename: L
authors.initials: L
authors.lastname: Eyzaguirre
authors.forename: K C
authors.initials: KC
authors.lastname: Brouwer
authors.forename: Y
authors.initials: Y
authors.lastname: Nadai
authors.forename: T L
authors.initials: TL
authors.lastname: Patterson
authors.forename: R
authors.initials: R
authors.lastname: Ramos
authors.forename: M
authors.initials: M
authors.lastname: Firestone Cruz
authors.forename: P
authors.initials: P
authors.lastname: Orozovich
authors.forename: S A
authors.initials: SA
authors.lastname: Strathdee
authors.forename: J K
authors.initials: JK
authors.lastname: Carr
mesh_terms: D003430:Cross-Sectional Studies; D005260:Female; D015658:HIV Infections / Q000453:epidemiology / Q000235:genetics*; D015497:HIV-1 / Q000145:classification / Q000235:genetics*; D006801:Humans; D008800:Mexico / Q000453:epidemiology; D008969:Molecular Sequence Data; D015995:Prevalence; D012194:RNA-Directed DNA Polymerase / Q000145:classification / Q000235:genetics*; D011477:Sex Work; D015819:Substance Abuse, Intravenous / Q000821:virology; D014481:United States / Q000453:epidemiology
chemical_list: D012194:RNA-Directed DNA Polymerase