title: High selectivity in new chiral separations of dansyl amino acids by cyclodextrin derivatives in electrokinetic chromatography.
abstract: Enantiomeric pairs of 11 dansyl derivatives of alpha-amino acids were used as analytes in electrokinetic chromatography to test the ability as chiral selectors of two pure derivatives of beta-cyclodextrin: the ethylendiamine derivative in primary position (CDen) and a member of a new class of receptors, the cysteamine-bridged hemispherodextrin THCMH. The selectivity obtained by the presence of the hemispherodextrin, appears particularly promising as shown by the large values of resolution obtained. The importance of a detailed analysis of these data is discussed in terms of suggestions for a rational approach to separation science.
authors.affiliation: Department Chemical Sciences, University of Catania, Catania, Italy. ecucinotta@unict.it
authors.forename: V
authors.initials: V
authors.lastname: Cucinotta
authors.forename: A
authors.initials: A
authors.lastname: Giuffrida
authors.forename: G
authors.initials: G
authors.lastname: Grasso
authors.forename: G
authors.initials: G
authors.lastname: Maccarrone
authors.forename: M
authors.initials: M
authors.lastname: Messina
authors.forename: G
authors.initials: G
authors.lastname: Vecchio
mesh_terms: D000596:Amino Acids / Q000302:isolation & purification*; D020374:Chromatography, Micellar Electrokinetic Capillary / Q000379:methods*; D003505:Cyclodextrins; D003619:Dansyl Compounds; D019075:Electrophoresis, Capillary; D013237:Stereoisomerism
chemical_list: D000596:Amino Acids; D003505:Cyclodextrins; D003619:Dansyl Compounds