KAI-1 protein expression in odontogenic cysts.
The KAI-1 tumor suppressor gene is widely distributed in normal tissues and its down-regulation may be correlated with the invasive phenotype and metastases in several different epithelial tumors. The aim of the present study was an evaluation of KAI-1 expression in radicular cysts (RC), follicular cysts (FC), orthokeratinized keratocysts (OOKC), and parakeratinized keratocysts (POKC). Eighty-five odontogenic cysts, 28 RC, 22 FC, and 35 OKC (16 OOKC, 19 POKC) were selected. All the POKC were negative and only four of 16 of the OOKC were positive for KAI-1. On the contrary, all RC and FC cases were positive and immunoreactivity for KAI-1 was detected throughout all the layers of the cyst epithelium. The lack of KAI-1 expression in POKC could help to explain the differences in the clinical and pathologic behavior of OKC and, according to what has been reported for epithelial tumors, could be related to the increased aggressive behavior and invasiveness of OKC.
Iezzi
Giovanna
G
Dental School, University of Chieti-Pescara, Italy.
Piattelli
Adriano
A
Artese
Luciano
L
Goteri
Gaia
G
Fioroni
Massimiliano
M
Rubini
Corrado
C
D005497:Follicular Cyst / Q000737:chemistry; D015870:Gene Expression; D006801:Humans; D007150:Immunohistochemistry; D007570:Jaw Cysts / Q000737:chemistry; D051861:Kangai-1 Protein / Q000032:analysis / Q000096:biosynthesis*; D007633:Keratins; D009807:Odontogenic Cysts / Q000737:chemistry*; D009808:Odontogenic Tumors / Q000737:chemistry
C497688:CD82 protein, human; D051861:Kangai-1 Protein; D007633:Keratins