title: Perception of comfort during transcranial DC stimulation: effect of NaCl solution concentration applied to sponge electrodes.
abstract: OBJECTIVE
  To investigate the relationship between perception of comfort and electrolyte concentration and applied voltage during transcranial direct current stimulation (tDCS).
  
  
  METHODS
  NaCl solutions (15, 140 and 220 mM NaCl) or deionised water were used as electrolytes to dampen tDCS sponge electrodes. Subjects (14, 7 M, 20-60 years of age) rated comfort on an 11-point scale during 2 min of tDCS (1 mA).
  
  
  RESULTS
  Overall participants rated tDCS as comfortable. Perception of comfort was negatively correlated with NaCl concentration (Spearman's rho=-0.88; p<0.05), and a logarithmic relationship was found between applied voltage and ionic strength of electrolytes (Pearson's r=-0.635; p<0.01). There was no relationship between applied voltage and perception of comfort.
  
  
  CONCLUSIONS
  The application of NaCl solutions between 15 and 140 mM to sponge electrodes is more likely to be perceived as comfortable during tDCS.
  
  
  CONCLUSIONS
  The reporting of solution concentration and ratings of perception would be useful adjuncts to tDCS studies.
authors.affiliation: Centre for Neuromuscular and Neurological Disorders, University of Western Australia, Australia. dundaj02@student.uwa.edu.au
authors.forename: J E
authors.initials: JE
authors.lastname: Dundas
authors.forename: G W
authors.initials: GW
authors.lastname: Thickbroom
authors.forename: F L
authors.initials: FL
authors.lastname: Mastaglia
mesh_terms: D000328:Adult; D004305:Dose-Response Relationship, Drug; D004558:Electric Stimulation / Q000009:adverse effects / Q000379:methods*; D004566:Electrodes / Q000009:adverse effects; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011537:Pruritus / Q000139:chemically induced; D012965:Sodium Chloride / Q000494:pharmacology*
chemical_list: D012965:Sodium Chloride