title: The role of interleukin-11 to prevent chemotherapy-induced thrombocytopenia in patients with solid tumors, lymphoma, acute myeloid leukemia and bone marrow failure syndromes.
abstract: Thrombocytopenia occurs at various grades of severity in patients with malignancies undergoing myelosuppressive chemotherapy. In most instances, this is the major dose-limiting hematologic toxicity, especially in the treatment of potentially curable cancers. The standard preventive measure against chemotherapy-induced thrombocytopenia has been dose reduction and/or dose delay. This can often lead to poor outcomes, including reduced disease free periods and overall survival. With the availability of a platelet growth factor, recombinant human interleukin (IL)-11, an effective way to prevent chemotherapy-induced thrombocytopenia and accelerate platelet recovery, can now be provided to patients. The use of recombinant human IL-11 has also been extended to include patients with prolonged thrombocytopenia, such as those with bone marrow failure syndromes. With the use of recombinant human IL-11 in both malignant and non-malignant conditions, adverse reactions often seen with platelet transfusions, such as transfusion reactions, viral and bacterial infections and platelet refractoriness, can now be decreased or avoided.
authors.affiliation: Departments of Pediatrics, Morgan Stanley Children's Hospital of New York Presbyterian, Columbia University, New York, NY 10032, USA.
authors.forename: Monica
authors.initials: M
authors.lastname: Bhatia
authors.forename: Virginia
authors.initials: V
authors.lastname: Davenport
authors.forename: Mitchell S
authors.initials: MS
authors.lastname: Cairo
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001855:Bone Marrow Diseases / Q000188:drug therapy; D006801:Humans; D017370:Interleukin-11 / Q000502:physiology / Q000627:therapeutic use*; D008954:Models, Biological; D009369:Neoplasms / Q000188:drug therapy*; D017713:Platelet Transfusion; D013921:Thrombocytopenia / Q000139:chemically induced* / Q000517:prevention & control*
chemical_list: D000970:Antineoplastic Agents; D017370:Interleukin-11