Para Vertebral Abscess and Rib Osteomyelitis due to Aspergillous Fumigatus in a Patient with Chronic Granulomatous Disease.
Chronic granulomatous disease is an infrequent primary immunodeficiency characterized by defective intracellular killing of ingested microorganisms thereby making patients highly susceptible to recurrent lite threatening bacterial and fungal infections. In this study, we review the medical course of an 8 yrs old girl with AR-CGD. She suffered from recurrent dermal and deep abscesses, retractable salmonellosis, disseminated BCGosis, recurrent aspergillus infection presenting as mandibular osteomyelitis and pulmonary involvement with invasion to rib and vertebral bodies. Despite of longterm IV amphotricin B, itraconazole and IFN-gamma administration, and surgical interventions (drainage and resection), she died in spite of long term antibiotic anti fungal prophylaxis and interferon-gamma administrations, invasive aspergillosis resistant to current conventional therapies is the cause of 1/2 to 1/3 of CGD deaths.
Farhoudi
A
A
Department of Immunology and Allergy, Department of Pediatric infectious disease, Children Medical Centre, Tehran University of Medical Sciences, Tehran, Iran.
Siadati
A
A
Atarod
Lila
L
Tabatabaei
P
P
Mamishi
Setareh
S
Khotaii
Gh
G
Armin
Sh
Sh
Shirvani
F
F