Importance of collection tube during clinical studies of oseltamivir.
Ex vivo conversion of the anti-influenza drug oseltamivir to its active metabolite can be inhibited by the esterase inhibitor dichlorvos or by using commercial fluoride-oxalate tubes. Oseltamivir and its active metabolite remain intact in plasma samples during a proposed virus heat inactivation step: incubation at 60 degrees C for 45 min.
Lindegardh
Niklas
N
Wellcome Trust-Mahidol University-Oxford Tropical Medicine Research Programme, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand. niklas@tropmedres.ac
Davies
Geraint R
GR
Hien
Tran Tinh
TT
Farrar
Jeremy
J
Singhasivanon
Pratap
P
Day
Nicholas P J
NP
White
Nicholas J
NJ
D000998:Antiviral Agents / Q000097:blood*; D001800:Blood Specimen Collection / Q000379:methods*; D004355:Drug Stability; D006801:Humans; D053139:Oseltamivir / Q000097:blood*; D013696:Temperature
D000998:Antiviral Agents; D053139:Oseltamivir