title: Practical issues drawn from the implementation of the integrated test for Down syndrome screening into routine clinical practice.
abstract: We have evaluated a cohort of women booked for antenatal care at University College London Hospitals. The uptake of screening was 64.4% and was significantly higher (73 versus 46%) in women who booked before 14 weeks. Of the women who booked before 14 weeks, 96.8% opted for the integrated test (IT). Overall, 5.3% failed to attend for the second blood test. The false-positive rate in the women who had the IT was 2.9%. All 11 cases of Down syndrome were detected prenatally. Our study is the first to evaluate implementation of the IT into routine clinical practice.
authors.affiliation: Department of Fetal Medicine, Elizabeth Garret Anderson and Obstetric Hospital, University College Hospital, London, UK.
authors.forename: B
authors.initials: B
authors.lastname: Weisz
authors.forename: P
authors.initials: P
authors.lastname: Pandya
authors.forename: L
authors.initials: L
authors.lastname: Chitty
authors.forename: P
authors.initials: P
authors.lastname: Jones
authors.forename: W
authors.initials: W
authors.lastname: Huttly
authors.forename: C
authors.initials: C
authors.lastname: Rodeck
mesh_terms: D000293:Adolescent; D000328:Adult; D004314:Down Syndrome / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008403:Mass Screening / Q000379:methods* / Q000706:statistics & numerical data; D048208:Nuchal Translucency Measurement; D010342:Patient Acceptance of Health Care; D011247:Pregnancy; D011266:Pregnancy-Associated Plasma Protein-A; D011296:Prenatal Diagnosis / Q000379:methods*
chemical_list: D011266:Pregnancy-Associated Plasma Protein-A