Highly functionalized and stereocontrolled syntheses of 2-(2-methylenecycloalkyl)-furan derivatives by Pd-catalyzed cycloreduction.
[structure: see text]. We have discovered a new method employing Pd-catalyzed cycloreduction of conjugated enynals 1 bearing an alkyne unit leading to the corresponding 2-(2-methylenecycloalkyl)-furans 2a-j and a related compound 7 in good to excellent yields.
Oh
Chang Ho
CH
Department of Chemistry, Hanyang University, Sungdong-Gu, Seoul, Korea. changho@hanyang.ac.kr
Park
Hyun Mi
HM
Park
Dai In
DI