title: Apical ballooning syndrome without myocardial necrosis: proof of concept from a case report.
abstract: The "apical ballooning" is a cardiac syndrome characterized by acute extensive but reversible akinesia of the apex and mid part of the left ventricle (LV), without obstructive coronary artery disease (CAD), triggered by emotional or physical stress, accompanied by chest pain and/or dyspnoea, electrocardiographic changes mimicking acute coronary syndromes (ACS), and minimal but, to date, obligatory release of cardiac enzymes. Today the precise aetiology remains unknown, but prognosis is generally excellent. We hereby report a unique case of a 60-year-old woman presenting with transient wide anterolateral akinesia and severe LV dysfunction with persistently normal myocardial markers, despite the extent of wall motion abnormalities. This clinical vignette is the first proof of the concept that timely recognition and management may be able to prevent myocardial necrosis in patients with apical ballooning syndrome.
authors.forename: Marzia
authors.initials: M
authors.lastname: Lotrionte
authors.forename: Rosaria
authors.initials: R
authors.lastname: Natali
authors.forename: Domenico
authors.initials: D
authors.lastname: Ciuffetta
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Biondi-Zoccai
authors.forename: Marinica
authors.initials: M
authors.lastname: Savino
authors.forename: Gianluca
authors.initials: G
authors.lastname: Comerci
authors.forename: Francesco
authors.initials: F
authors.lastname: Loperfido
mesh_terms: D015415:Biomarkers / Q000378:metabolism; D009202:Cardiomyopathies / Q000175:diagnosis* / Q000378:metabolism; D005260:Female; D006801:Humans; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism / Q000473:pathology; D009336:Necrosis / Q000378:metabolism; D013577:Syndrome; D018487:Ventricular Dysfunction, Left / Q000175:diagnosis* / Q000378:metabolism
chemical_list: D015415:Biomarkers