Triiodothyronine suppresses humoral immunity but not T-cell-mediated immune response in incubating female eiders (Somateria mollissima).
Immunity is believed to share limited resources with other physiological functions and this may partly account for the fitness costs of reproduction. Previous studies have shown that the acquired immunity of female common eiders (Somateria mollissima) is suppressed during the incubation fast. To save energy, triiodothyronine (T(3)) is adaptively decreased during fasting in most bird species, despite T(3) levels are maintained throughout incubation in female eiders. However, the relationship between thyroid hormones and the immune system is not fully understood. The current study aimed to determine the endocrine mechanisms that underlie immunosuppression in incubating female eiders. To this end we assessed the effects of exogenous T(3) on both components of the acquired immune system in 42 free-ranging incubating birds. Half of the females were implanted with T(3) pellets, while the other half sham implanted served as control. We measured variations in the immunoglobulin index, the T-cell-mediated immune response, body mass, and plasma parameters in both groups before and after manipulation. T(3) levels in implanted females were four times higher and mass loss was 40% greater than in control females. Implanted females also showed an 18% decrease in the immunoglobulin index, while the T-cell-mediated immune response was not significantly affected by the treatment. Finally, the treatment did not induce any significant changes in corticosterone levels. Our study shows that exogenous T(3) decreased only one component of the acquired immune system. We suggest that the immunosuppressive effect of T(3) could be mediated by its effects on body fat reserves. Further experiments are required to determine: (1) the relationship between adiposity and immune function, (2) the adaptive significance of immunosuppression during incubation in eiders.
Bourgeon
Sophie
S
Institut Pluridisciplinaire Hubert Curien (IPHC), Département Ecologie, Physiologie et Ethologie (DEPE), UMR 7178 CNRS-ULP, 23 rue Becquerel, F-67087 Strasbourg Cedex 2, France. sophie.bourgeon@c-strasbourg.fr
Raclot
Thierry
T
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D001835:Body Weight / Q000187:drug effects; D003345:Corticosterone / Q000097:blood; D004343:Drug Implants; D004372:Ducks / Q000097:blood / Q000276:immunology*; D005260:Female; D007111:Immunity, Cellular / Q000187:drug effects*; D009425:Nesting Behavior / Q000187:drug effects; D013601:T-Lymphocytes / Q000187:drug effects* / Q000276:immunology; D014284:Triiodothyronine / Q000008:administration & dosage / Q000494:pharmacology*
D004343:Drug Implants; D014284:Triiodothyronine; D003345:Corticosterone