Molecular analysis of duck hepatitis virus type 1.
The genome sequence of a duck hepatitis virus type 1 (DHV-1) strain was determined. Comparative sequence analysis showed that the genome possesses a typical picornarivus organization and also exhibits several unique features, such as the similarity of internal ribosome entry site to that of Porcine teschovirus 1 and Hepatitis C virus, the presence of a longest 3' untranslated region and a shorter leader protein in the Picornaviridae, the absence of a predicted maturation cleavage of VP0, the association of an aphthovirus-like 2A1 and parechovirus-like 2A2, and the unprecedented presence of an AIG1 domain in the N-terminus of 2A2. It is concluded that DHV-1 belongs to a new group of the family Picornaviridae that may form a separate genus most closely related to the genus Parechovirus.
Ding
Chunyu
C
Key Laboratory of Preventive Veterinary Medicine of Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, YuanMingYuan west road No. 2, Beijing 100094, PR China.
Zhang
Dabing
D
D020413:3' Untranslated Regions / Q000235:genetics; D000595:Amino Acid Sequence; D001483:Base Sequence; D016679:Genome, Viral; D004371:Hepatitis Virus, Duck / Q000145:classification / Q000235:genetics*; D008969:Molecular Sequence Data; D016415:Sequence Alignment; D013045:Species Specificity
D020413:3' Untranslated Regions