title: Human serum amyloid A protein inhibits hepatitis C virus entry into cells.
abstract: Serum amyloid A (SAA) is an acute-phase protein induced by a variety of inflammatory stimuli, including bacterial and viral infections. SAA was recently found to function as an opsonin for gram-negative bacteria. We report here that SAA inhibited hepatitis C virus (HCV) infection in cultured cells. SAA reduced HCV infectivity in a dose-dependent manner when added during HCV infection but not after virus entry. SAA bound HCV virions and specifically blocked HCV entry but did not affect virus attachment. These findings suggest that SAA functions as part of the host innate immune defense mechanisms against HCV infection in humans.
authors.affiliation: Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky College of Medicine, 800 Rose Street, Lexington, KY 40536, USA.
authors.forename: Zhaohui
authors.initials: Z
authors.lastname: Cai
authors.forename: Lei
authors.initials: L
authors.lastname: Cai
authors.forename: Jieyun
authors.initials: J
authors.lastname: Jiang
authors.forename: Kyung-Soo
authors.initials: KS
authors.lastname: Chang
authors.forename: Deneys R
authors.initials: DR
authors.lastname: van der Westhuyzen
authors.forename: Guangxiang
authors.initials: G
authors.lastname: Luo
mesh_terms: D045744:Cell Line, Tumor; D016174:Hepacivirus / Q000472:pathogenicity*; D006526:Hepatitis C / Q000517:prevention & control* / Q000821:virology*; D006801:Humans; D000685:Serum Amyloid A Protein / Q000502:physiology*; D053586:Virus Internalization
chemical_list: D000685:Serum Amyloid A Protein