Antiparasitic activity of some New Caledonian medicinal plants.
Twenty-nine extracts of 18 medicinal plants used in New Caledonia by traditional healers to treat inflammation, fever and in cicatrizing remedies were evaluated in vitro against several parasites (Leishmania donovani, Trypanosoma brucei brucei, Trichomonas vaginalis and Caenorhabditis elegans). Among the selected plants, Scaevola balansae and Premna serratifolia L. were the most active against Leishmania donovani with IC(50) values between 5 and 10microg/ml. The almond and aril extracts from Myristica fatua had an IC(50) value of 0.5-5microg/ml against Trypanosoma brucei brucei. Only Scaevola balansae extract presented a weak activity against Trichomonas vaginalis. The almond extract from Myristica fatua presented significant activity against Caenorhabditis elegans (IC(50) value of 6.6+/-1.2microg/ml).
Desrivot
Julie
J
Laboratoire de Pharmacognosie (UMR CNRS 8076-BioCIS), Université Paris-Sud 11, Faculté de Pharmacie, 92296 Châtenay-Malabry, France.
Waikedre
Jean
J
Cabalion
Pierre
P
Herrenknecht
Christine
C
Bories
Christian
C
Hocquemiller
Reynald
R
Fournet
Alain
A
D000818:Animals; D000871:Anthelmintics / Q000494:pharmacology*; D000981:Antiprotozoal Agents / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D066298:In Vitro Techniques; D020128:Inhibitory Concentration 50; D009510:New Caledonia; D010936:Plant Extracts / Q000494:pharmacology; D010946:Plants, Medicinal; D014344:Trypanocidal Agents / Q000494:pharmacology
D000871:Anthelmintics; D000981:Antiprotozoal Agents; D010936:Plant Extracts; D014344:Trypanocidal Agents