Cytotoxic constituents isolated from the fruit bodies of Hypsizigus marmoreus.
The bioactivity-guided fractionation of chloroform extracts of the fruit bodies of Hypsizigus marmoreus led to our isolation of (22E,24R)-ergosta-7,22-diene-3beta,5alpha,6beta-triol (1), ergosterol-3-O-beta-D-glucopyranoside (2), 5alpha,8alpha-epidioxyergosta-6,22-dien-3beta-ol (3), hypsiziprenol A9 (4), hypsiziprenol AA8 (5), hypsiziprenol AA9 (6) and hypsiziprenol BA10 (7). Among these seven isolates, compound 2 was identified for the first time from this plant. All compounds (1-7) exhibited moderate cytotoxicity towards cultured human colon carcinoma (HT-29), human breast carcinoma (MCF-7) and human hepatoblastoma (HepG-2) cell lines.
Xu
Ming-Lu
ML
College of Pharmacy, Yeungnam University, Gyongsan 712-749, Korea.
Choi
Jae-Young
JY
Jeong
Byeong-Seon
BS
Li
Gao
G
Lee
Kap-Rang
KR
Lee
Chong-Soon
CS
Woo
Mi-Hee
MH
Lee
Eung Seok
ES
Jahng
Yurngdong
Y
Chang
Hyeun-Wook
HW
Lee
Seung-Ho
SH
Son
Jong-Keun
JK
D000363:Agaricales / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001681:Biological Assay / Q000379:methods; D002470:Cell Survival / Q000187:drug effects; D005591:Chemical Fractionation / Q000379:methods; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D004305:Dose-Response Relationship, Drug; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019073:HT29 Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D015394:Molecular Structure; D009183:Mycotoxins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013678:Technology, Pharmaceutical / Q000379:methods; D059004:Topoisomerase I Inhibitors; D059005:Topoisomerase II Inhibitors
D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; D009183:Mycotoxins; D059004:Topoisomerase I Inhibitors; D059005:Topoisomerase II Inhibitors