title: Peripheral gangrene associated with Kawasaki disease and successful management using prostacycline analogue: a case report.
abstract: We report a case of child-onset Kawasaki disease that presented as a prolonged fever and manifested with coronary aneurysms and peripheral gangrene of the lower limbs. Therapy with intravenous immunoglobulins, corticosteroids, aspirin, anticoagulants, and ilomedine, a prostacyclin analogue, resulted in rapid improvement in the patient's condition without extremity loss. Those treating patients with Kawasaki disease must be aware of possible vascular ischemia in the disease process that is reversible by early intervention treatments, including the use of a prostacycline analogue, that improve quality of life.
authors.affiliation: Department of Cardiovascular Surgery, Hacettepe University Medical Faculty, Ankara, Turkey. ofdogan@hacettepe.edu.tr
authors.forename: Omer Faruk
authors.initials: OF
authors.lastname: Dogan
authors.forename: Ates
authors.initials: A
authors.lastname: Kara
authors.forename: Ilker
authors.initials: I
authors.lastname: Devrim
authors.forename: Hasan
authors.initials: H
authors.lastname: Tezer
authors.forename: Nesrin
authors.initials: N
authors.lastname: Besbas
authors.forename: Seza
authors.initials: S
authors.lastname: Ozen
authors.forename: Gulten
authors.initials: G
authors.lastname: Secmeer
authors.forename: Cem
authors.initials: C
authors.lastname: Yorgancioglu
authors.forename: Erkmen
authors.initials: E
authors.lastname: Boke
mesh_terms: D002648:Child; D011464:Epoprostenol / Q000008:administration & dosage* / Q000031:analogs & derivatives*; D005260:Female; D005734:Gangrene / Q000188:drug therapy / Q000209:etiology; D006801:Humans; D007511:Ischemia / Q000209:etiology / Q000517:prevention & control*; D007866:Leg / Q000098:blood supply* / Q000473:pathology*; D009080:Mucocutaneous Lymph Node Syndrome / Q000150:complications* / Q000188:drug therapy*; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage; D016896:Treatment Outcome
chemical_list: D010975:Platelet Aggregation Inhibitors; D011464:Epoprostenol