[Partial androgen deficiency in aging male (Padam syndrome): terminology and current approaches to choice of replacement hormonal therapy].
The authors propose a novel approach to treatment of PADAM syndrome based on stimulation of synthesis of endogenic testosterone. A total of 150 patients with PADAM were examined in the Endocrinological Research Center. The examination included physical and andrological examinations with digital rectal investigation of the prostate, filling-in questionnaires, hormonal and biochemical tests. In view of positive test with chorionic gonadotropin (CG), therapy of choice was stimulating therapy with CG. The dose was adjusted individually - from 1000 to 3000 units once in 4 days (1000 units dose was given to 20% patients, 2000 - to 70% and 3000 - to 10% patients). Efficacy did not reduce in long-term treatment. The authors make the following conclusion: choice of PADAM therapy should be individual and based on the age of the patient, body mass index, the necessity to retain spermatogenesis, packed cell volume, associated diseases. Secondary nature of PADAM and positive test for CG allows usage of CG as a perspective therapy in prevention and treatment of age-related lowering of testosterone.
Kalinchenko
S Iu
SIu
Tishova
Iu A
IuA
Vorslov
L O
LO
Nesterov
M N
MN
D000328:Adult; D000375:Aging / Q000378:metabolism; D000728:Androgens / Q000172:deficiency*; D047649:Andropause; D006063:Chorionic Gonadotropin / Q000627:therapeutic use*; D020249:Hormone Replacement Therapy / Q000379:methods*; D006801:Humans; D007006:Hypogonadism / Q000145:classification / Q000175:diagnosis / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D013577:Syndrome; D013739:Testosterone / Q000096:biosynthesis*
D000728:Androgens; D006063:Chorionic Gonadotropin; D013739:Testosterone