Cyathane diterpenes from Sarcodon cyrneus and evaluation of their activities of neuritegenesis and nerve growth factor production.
Two new cyathane diterpenes, cyrneine C (4) and D (5), were isolated from the mushroom Sarcodon cyrneus, along with previously isolated cyrneine A, B and glaucopine C. The structures of the novel diterpenoids were determined by the analysis of spectroscopic data. Effects of the cyrneines and glaucopine C on the NGF gene expression in 1321N1 cells and on neurite outgrowth on PC12 cells were evaluated.
Marcotullio
Maria Carla
MC
Dipartimento di Chimica e Tecnologia del Farmaco-Sez. Chimica Organica, Università degli Studi, 06123 Perugia, Italy. marcotu@unipg.it
Pagiotti
Rita
R
Maltese
Federica
F
Oball-Mond Mwankie
Gildas Norbert
GN
Hoshino
Tomohiro
T
Obara
Yutaro
Y
Nakahata
Norimichi
N
D000363:Agaricales / Q000737:chemistry*; D000818:Animals; D002478:Cells, Cultured; D002855:Chromatography, Thin Layer; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D008401:Gas Chromatography-Mass Spectrometry; D015870:Gene Expression / Q000187:drug effects; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008968:Molecular Conformation; D009414:Nerve Growth Factors / Q000096:biosynthesis / Q000138:chemical synthesis* / Q000494:pharmacology*; D016501:Neurites / Q000187:drug effects*; D016716:PC12 Cells; D051381:Rats; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013055:Spectrophotometry, Infrared; D017550:Spectroscopy, Fourier Transform Infrared
D004224:Diterpenes; D007202:Indicators and Reagents; D009414:Nerve Growth Factors; C497675:cyathane