Direct C-arylation of beta-enamino esters and ketones with arynes.
An efficient, mild, and general method for the C-arylation of beta-enamino esters and ketones with arynes has been developed. This methodology provides a facile and direct access to a variety of substituted aromatic beta-enamino compounds in moderate to excellent yield. [reaction: see text]
Ramtohul
Yeeman K
YK
Department of Medicinal Chemistry, Merck Frosst Centre for Therapeutic Research, Merck Frosst Canada & Co. Inc., P.O. Box 1005, 16711 Trans Canada Highway, Kirkland, Quebec, Canada H9H 3L1. yeeman_ramtohul@merck.com
Chartrand
Anik
A
D020650:Combinatorial Chemistry Techniques; D004952:Esters / Q000737:chemistry*; D006841:Hydrocarbons, Aromatic / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D015394:Molecular Structure; D014297:Trimethylsilyl Compounds / Q000737:chemistry
D004952:Esters; D006841:Hydrocarbons, Aromatic; D007659:Ketones; D014297:Trimethylsilyl Compounds