Hemorrhagic hereditary telangiectasia (Rendu-Osler disease) and infectious diseases: an underestimated association.
Among 353 patients with hereditary hemorrhagic telangiectasia retrospectively analyzed during the period 1985-2005, we identified 67 cases of severe infection that affected 48 patients (13.6%). Extracerebral infections accounted for 67% of all infections, and most involved Staphylococcus aureus and were associated with prolonged epistaxis. Cerebral infections accounted for 33% of all infections, were mainly due to multiple and anaerobic bacteria, and were associated with the presence of pulmonary arteriovenous malformations and a short duration of epistaxis.
Dupuis-Girod
Sophie
S
Service de Génétique et Centre de Référence sur la Maladie de Rendu-Osler, Hôpital de l'Hôtel Dieu, Lyon, France. sophie.dupuis-girod@chu-lyon.fr
Giraud
Sophie
S
Decullier
Evelyne
E
Lesca
Gaetan
G
Cottin
Vincent
V
Faure
Frédéric
F
Merrot
Olivier
O
Saurin
Jean-Christophe
JC
Cordier
Jean-François
JF
Plauchu
Henri
H
D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D015331:Cohort Studies; D003141:Communicable Diseases / Q000453:epidemiology* / Q000382:microbiology*; D015897:Comorbidity; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D018570:Risk Assessment; D012720:Severity of Illness Index; D017678:Sex Distribution; D016019:Survival Analysis; D013683:Telangiectasia, Hereditary Hemorrhagic / Q000175:diagnosis / Q000453:epidemiology*