[Microalbuminuria is a strong determinant for ischemic heart disease--also among non-diabetics].
Population studies have indicated that a urinary albumin excretion above 5 microg/min confers increased relative risk of coronary heart disease similar to the relative risk associated with the metabolic syndrome. This is perhaps because microalbuminuria reflects the presence of subclinical atherosclerosis. In a series of pathophysiological studies microalbuminuria was not associated with systemic transvascular sieving of lipoproteins. Measurement of urinary albumin excretion may be useful for risk stratification in primary health care for prevention of coronary heart disease. Intervention trials should be conducted.
Jensen
Jan Skov
JS
Gentofte Hospital, Kardiologisk Afdeling P, Hellerup. jaje@geh.regionh.dk
D000419:Albuminuria / Q000150:complications / Q000175:diagnosis*; D050197:Atherosclerosis / Q000150:complications / Q000652:urine; D003327:Coronary Disease / Q000209:etiology / Q000517:prevention & control / Q000652:urine*; D006801:Humans; D017202:Myocardial Ischemia / Q000175:diagnosis / Q000209:etiology / Q000652:urine*; D012307:Risk Factors