HPLC-ICP-MS and HPLC-ES-MS/MS characterization of synthetic seleno-arsenic compounds.
Various toxicological and metabolic interactions have been reported to exist between arsenic and selenium. In the present study, synthetic seleno-arsenic compounds, potentially suitable for probing metabolic interactions between these two elements, were prepared and tentatively characterized by using high-performance liquid chromatography (HPLC)-electrospray tandem mass spectrometry and HPLC-inductively coupled plasma mass spectrometry. In analogy to the recently identified thio-arsenic species, which can be prepared from their corresponding oxo-arsenic species via reaction with H(2)S, the seleno-arsenic compounds were also derived from oxo-arsenic compounds via reaction with H(2)Se. Figure H(2)Se bubbled into solutions containing oxo-arseno-sugars converts them into their seleno-arseno-sugar analogues.
Kanaki
Katerina
K
Environmental Chemical Processes Laboratory, Department of Chemistry, University of Crete, Voutes, 71003 Heraklion, Crete, Greece.
Pergantis
Spiros A
SA
D001152:Arsenicals / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D018036:Selenium Compounds / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods*; D053719:Tandem Mass Spectrometry / Q000379:methods*
D001152:Arsenicals; D018036:Selenium Compounds