The structure of Plasmodium vivax phosphatidylethanolamine-binding protein suggests a functional motif containing a left-handed helix.
The structure of a putative Raf kinase inhibitor protein (RKIP) homolog from the eukaryotic parasite Plasmodium vivax has been studied to a resolution of 1.3 A using multiple-wavelength anomalous diffraction at the Se K edge. This protozoan protein is topologically similar to previously studied members of the phosphatidylethanolamine-binding protein (PEBP) sequence family, but exhibits a distinctive left-handed alpha-helical region at one side of the canonical phospholipid-binding site. Re-examination of previously determined PEBP structures suggests that the P. vivax protein and yeast carboxypeptidase Y inhibitor may represent a structurally distinct subfamily of the diverse PEBP-sequence family.
Arakaki
Tracy
T
Structural Genomics of Pathogenic Protozoa Consortium, USA.
Neely
Helen
H
Boni
Erica
E
Mueller
Natasha
N
Buckner
Frederick S
FS
Van Voorhis
Wesley C
WC
Lauricella
Angela
A
DeTitta
George
G
Luft
Joseph
J
Hol
Wim G J
WG
Merritt
Ethan A
EA
D020816:Amino Acid Motifs / Q000502:physiology; D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites / Q000502:physiology; D018360:Crystallography, X-Ray; D008969:Molecular Sequence Data; D049488:Phosphatidylethanolamine Binding Protein / Q000737:chemistry* / Q000378:metabolism / Q000502:physiology*; D010966:Plasmodium vivax / Q000737:chemistry* / Q000378:metabolism; D011487:Protein Conformation; D047428:Protein Kinase Inhibitors / Q000737:chemistry / Q000378:metabolism; D017433:Protein Structure, Secondary / Q000502:physiology; D015800:Protozoan Proteins / Q000737:chemistry / Q000378:metabolism / Q000502:physiology
D049488:Phosphatidylethanolamine Binding Protein; D047428:Protein Kinase Inhibitors; D015800:Protozoan Proteins