title: Investigation as to the osteoinductivity of macroporous calcium phosphate cement in goats.
abstract: For bone formation in critical-sized or poor healing defects, osteoinductive behavior of synthetic bone grafts is crucial. Although the osteoconductive behavior of calcium phosphate (CaP) cement is generally accepted, its osteoinductive potential is less reported. In this study, osteoinduction of porous CaP cement was investigated. Four goats received each six subcutaneous placed prehardened porous CaP cement implants. Implantation time was 3 and 6 months. After explantation, histological evaluation and scoring with a histological grading scale for soft-tissue implants were performed. The histological sections revealed that the implants degraded for more than 50% over time. The implants had lost their macroporous structure from 3 months on. A medium-thick fibrous capsule with a few inflammatory cells surrounded the implants after 3 months. This capsule significantly decreased in thickness after 6 months. Throughout the implant ingrowth of fibrous tissue was seen with scattered foci of inflammatory cells. Cement particles were surrounded by a layer of inflammatory cells. The massive inflammatory response in the interstice was seen after 3 months, which disappeared after 6 months implantation. No bone formation was detected in any of the specimens. The fast degradation and thereby collapsing of the porous structure of our CaP cement implant might have prevented osteoinduction.
authors.affiliation: Department of Periodontology and Biomaterials, Radboud University Nijmegen, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands.
authors.forename: Esther W H
authors.initials: EW
authors.lastname: Bodde
authors.forename: Camille T R
authors.initials: CT
authors.lastname: Cammaert
authors.forename: Joop G C
authors.initials: JG
authors.lastname: Wolke
authors.forename: Paul H M
authors.initials: PH
authors.lastname: Spauwen
authors.forename: John A
authors.initials: JA
authors.lastname: Jansen
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry / Q000378:metabolism; D001843:Bone Cements / Q000737:chemistry / Q000378:metabolism*; D001861:Bone Regeneration / Q000502:physiology*; D002130:Calcium Phosphates / Q000737:chemistry / Q000378:metabolism*; D005260:Female; D006041:Goats; D020007:Implants, Experimental; D007249:Inflammation / Q000378:metabolism; D008422:Materials Testing; D010012:Osteogenesis / Q000502:physiology*; D016062:Porosity
chemical_list: D001672:Biocompatible Materials; D001843:Bone Cements; D002130:Calcium Phosphates; C020243:calcium phosphate