The application of bis(oxazoline) ligands in the catalytic enantioselective methallylation of aldehydes.
A series of symmetric and non-symmetric bis(oxazoline) ligands were applied in the Nozaki-Hiyama-Kishi methallylation of a range of aromatic and aliphatic aldehydes. A non-symmetrical ligand with tert-butyl/benzyl-substituted oxazolines provided the highest enantioselectivity of 99.5% for the methallylation of benzaldehyde.
Hargaden
Gráinne C
GC
Centre for Synthesis and Chemical Biology, Conway Institute of Biomolecular and Biomedical Research, School of Chemistry and Chemical Biology, University College Dublin, Belfield, Dublin 4, Ireland.
McManus
Helen A
HA
Cozzi
Pier Giorgio
PG
Guiry
Patrick J
PJ
D000447:Aldehydes / Q000737:chemistry*; D000498:Allyl Compounds / Q000138:chemical synthesis / Q000737:chemistry; D002384:Catalysis; D008024:Ligands; D015394:Molecular Structure; D010080:Oxazoles / Q000737:chemistry*; D013237:Stereoisomerism
D000447:Aldehydes; D000498:Allyl Compounds; D008024:Ligands; D010080:Oxazoles