title: Cutaneous Langerhans cell sarcoma: a case report and review of the literature.
abstract: Langerhans cell sarcoma (LCS) is a neoplastic proliferation of Langerhans cells that occurs in lymph nodes, liver, skin, spleen, lung, and bone. We report a case of LCS in a 47-year-old man with a 6-month history of scalp mass and cervical lymphadenopathy. Clinical and pathologic data were available. A histologic examination demonstrated a proliferation of cells with malignant cytologic features. Because of its poorly differentiated morphologic features, hematologic and nonhematologic entities were ruled out by immunohistochemical screening with a broad panel of antibodies. Ultrastructural studies demonstrating Birbeck granules and consistent expression of CD1a, S-100 protein, and langerin by immunohistochemistry were helpful in identifying the Langerhans cell origin.
authors.affiliation: Department of Pathology, University Hospital UPAEP, Puebla, Mexico.
authors.forename: Olga L
authors.initials: OL
authors.lastname: Bohn
authors.forename: Guillermo
authors.initials: G
authors.lastname: Ruiz-Argüelles
authors.forename: Leticia
authors.initials: L
authors.lastname: Navarro
authors.forename: Jesus
authors.initials: J
authors.lastname: Saldivar
authors.forename: Sergio
authors.initials: S
authors.lastname: Sanchez-Sosa
mesh_terms: D003594:Cytoplasmic Granules / Q000378:metabolism / Q000648:ultrastructure; D015972:Gene Expression Regulation, Neoplastic; D006258:Head and Neck Neoplasms / Q000378:metabolism / Q000648:ultrastructure*; D006801:Humans; D007801:Langerhans Cells / Q000378:metabolism / Q000648:ultrastructure*; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000096:biosynthesis; D012878:Skin Neoplasms / Q000378:metabolism / Q000648:ultrastructure*
chemical_list: D009363:Neoplasm Proteins