COX-2 inhibitors celecoxib and parecoxib: valuable options for postoperative pain management.
COX-2 inhibitors are equally as efficacious as the non-selective NSAIDs for the treatment of postoperative pain, but have the advantages of a better gastrointestinal side-effect profile as well as a lack of antiplatelet effects. There have been recent concerns regarding the cardiovascular side effects of COX-2 inhibitors. Nonetheless, they remain a valuable option for postoperative pain management. The pharmacology of these agents and available studies are reviewed.
Gajraj
Noor M
NM
Baylor Center for Pain Management, Baylor University Medical Center, 5575 Warren Parkway 220, Frisco, Texas 75034, USA. noorgajraj@aol.com
D000068579:Celecoxib; D052246:Cyclooxygenase 2 Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D007555:Isoxazoles / Q000494:pharmacology / Q000627:therapeutic use; D010149:Postoperative Pain / Q000188:drug therapy*; D011720:Pyrazoles / Q000494:pharmacology / Q000627:therapeutic use; D013449:Sulfonamides / Q000494:pharmacology / Q000627:therapeutic use; D016896:Treatment Outcome
D052246:Cyclooxygenase 2 Inhibitors; D007555:Isoxazoles; D011720:Pyrazoles; D013449:Sulfonamides; C409945:parecoxib; D000068579:Celecoxib