title: Oncologic principles in breast reconstruction.
abstract: Breast cancer is the most common malignancy in North American women. Although the incidence has risen over the last 20 years, mortality rates appear to be decreasing, possibly as a result of earlier detection and more effective therapy. Breast cancer is a heterogeneous group of conditions that can be divided into the noninvasive entities of lobular carcinoma in situ (LCIS) and ductal carcinoma-in-situ (DCIS), and invasive cancers. In this article, the spectrum of breast cancer is presented from the noninvasive entities, through invasive breast cancer types, to advanced and recurrent cancer. The rationales for current treatment options are presented. Evidence is presented for current adjuvant treatment options, and the rationale for surgical decision-making is presented.
authors.affiliation: Department of Radiation Oncology, Princess Margaret Hospital, University of Toronto, Toronto, ON, Canada.
authors.forename: B C John
authors.initials: BC
authors.lastname: Cho
authors.forename: David R
authors.initials: DR
authors.lastname: McCready
mesh_terms: D001365:Axilla / Q000601:surgery; D001943:Breast Neoplasms / Q000235:genetics / Q000473:pathology / Q000628:therapy*; D002277:Carcinoma / Q000235:genetics / Q000473:pathology / Q000628:therapy*; D017024:Chemotherapy, Adjuvant; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008197:Lymph Node Excision; D016462:Mammaplasty; D008408:Mastectomy; D009364:Neoplasm Recurrence, Local / Q000628:therapy; D018714:Radiotherapy, Adjuvant