The inflammation hypothesis and its potential relevance to statin therapy.
Inflammatory cytokines have a central role in atherogenesis and plaque rupture. These mediators, including tumor necrosis factor, interleukins, and matrix metalloproteinases and transforming growth factor-beta are also prominent in other chronic progressive diseases characterized by cell apoptosis and tissue fibrosis. This review extends the inflammation hypothesis to critical analysis of studies to bearing on the role of inflammation in chronic conditions that commonly accompany coronary disease. Because statins inhibit the expression of inflammatory mediators, the review then analyzes the laboratory and clinical data that may justify trials of statins in nonatherosclerotic disease. In conclusion, despite far different clinical presentations, chronic progressive diseases characterized by apoptosis and fibrosis have persistence of inflammatory cytokines as a final common pathway, and thus may benefit from the pleiotropic effects of statin therapy.
Forrester
James S
JS
Cedars-Sinai Medical Center, Los Angeles, California, USA. forrester@cshs.org
Libby
Peter
P
D002908:Chronic Disease; D016207:Cytokines / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000494:pharmacology*; D007249:Inflammation / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology
D016207:Cytokines; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors