Synthesis and antimicrobial evaluation of some new thiazole, thiazolidinone and thiazoline derivatives starting from 1-chloro-3,4-dihydronaphthalene-2-carboxaldehyde.
The thiosemicarbazones (3 and 6) and N-arylidene cyanoacetohydrazide (12) were prepared and used as key intermediates for the synthesis of 4-thiazolidinones (4, 5, 7-9), thiazoles (10a,b and 11a-d) and thiazoline (13) derivatives. Treatment of 13 with a mixture of triethylorthoformate and acetic anhydride afforded thiazolo[5,4-d]pyrimidinone derivative (14). The newly synthesized compounds were characterized by IR, (1)H NMR and mass spectral studies. Representative compounds of the synthesized products were tested and evaluated as antimicrobial agents.
Bondock
Samir
S
Department of Chemistry, Faculty of Science, Mansoura University, El-gomhuria street, El-Dakhlia, ET-35516 Mansoura, Egypt. Bondock@mans.edu.eg
Khalifa
Wesam
W
Fadda
Ahmed A
AA
D000447:Aldehydes / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005658:Fungi / Q000187:drug effects; D015394:Molecular Structure; D009281:Naphthalenes / Q000737:chemistry*; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology
C522582:1-chloro-3,4-dihydronaphthalene-2-carboxaldehyde; D000447:Aldehydes; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D009281:Naphthalenes; D013844:Thiazoles