Sesterterpene sulfates as isocitrate lyase inhibitors from tropical sponge Hippospongia sp.
Two sesterterpene sulfates (1-2) were isolated from tropical sponge Hippospongia sp. and their inhibitory activities against isocitrate lyase (ICL) from the rice blast fungus Mgnaporthe grisea were evaluated. Compound 3 was obtained by hydrolysis of compound 1. Compounds 1 and 3 were found to be potent ICL inhibitors, which inhibited appressorium formation and C(2) carbon utilization in M. grisea. Our results suggest that ICL plays crucial role in appressorium formation of M. grisea and is a new target for the protection of rice blast disease.
Lee
Hyi-Seung
HS
Marine Natural Products Laboratory, Korea Ocean Research and Development Institute, Ansan PO Box 29, Seoul 425-600, Republic of Korea.
Lee
Tae-Hoon
TH
Yang
Seung Hwan
SH
Shin
Hee Jae
HJ
Shin
Jongheon
J
Oh
Ki-Bong
KB
D000085:Acetates / Q000737:chemistry; D000818:Animals; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D004305:Dose-Response Relationship, Drug; D015195:Drug Design; D004353:Drug Evaluation, Preclinical; D005947:Glucose / Q000737:chemistry; D020128:Inhibitory Concentration 50; D007522:Isocitrate Lyase / Q000037:antagonists & inhibitors* / Q000737:chemistry*; D008956:Models, Chemical; D011161:Porifera; D054830:Sesterterpenes; D013431:Sulfates / Q000737:chemistry*; D013463:Sulfuric Acid Esters / Q000737:chemistry; D013729:Terpenes / Q000737:chemistry*
D000085:Acetates; D000935:Antifungal Agents; D054830:Sesterterpenes; D013431:Sulfates; D013463:Sulfuric Acid Esters; D013729:Terpenes; D007522:Isocitrate Lyase; D005947:Glucose