title: [A case of sarcoidosis with diabetes insipidus].
abstract: A 15-year-old girl was admitted to our hospital because of polydipsia, polyuria, bilateral hilar lymphadenopathy and uveitis. A diagnosis of sarcoidosis with central diabetes insipidus was made by radiological, serological, bronchoalveolar lavage examinations, fluid restriction test and vasopression test. Prednisolone therapy improved all of her clinical findings except diabetes insipidus. So she had to continue intranasal 1-desamino-8-arginine vasopressin (DDAVP) therapy. In addition, we reviewed the clinical features of 27 patients of sarcoidosis with diabetes insipidus reported in Japan. They included 12 patients in young men and 21 patients having uveitis. These patients showed low frequency of lung complications in comparison with sarcoidosis without diabetes insipidus. Steroid therapy improved the symptoms of diabetes insipidus in only 3 patients, and all these 3 patients started steroid therapy within 1 month after the onset. Therefore we think that early diagnosis and treatment are important. Though central neurosarcoidosis was generally considered to have poor prognosis, there were only 3 patients who had recurrence by steroid tapering.
authors.affiliation: Second Department of Internal Medicine, Nagasaki University School of Medicine.
authors.forename: Kanako
authors.initials: K
authors.lastname: Sugiyama
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Mukae
authors.forename: Noriho
authors.initials: N
authors.lastname: Sakamoto
authors.forename: Atsuko
authors.initials: A
authors.lastname: Iwata
authors.forename: Misato
authors.initials: M
authors.lastname: Amenomori
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ishimoto
authors.forename: Hanako
authors.initials: H
authors.lastname: Miyazaki
authors.forename: Keiko
authors.initials: K
authors.lastname: Hisatomi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ishii
authors.forename: Seiko
authors.initials: S
authors.lastname: Nakayama
authors.forename: Yuji
authors.initials: Y
authors.lastname: Ishimatsu
authors.forename: Shigeru
authors.initials: S
authors.lastname: Kohno
mesh_terms: D000293:Adolescent; D050034:Antidiuretic Agents / Q000008:administration & dosage; D003894:Deamino Arginine Vasopressin / Q000008:administration & dosage; D020790:Diabetes Insipidus, Neurogenic / Q000188:drug therapy / Q000209:etiology*; D005260:Female; D006801:Humans; D008206:Lymphatic Diseases / Q000150:complications; D012507:Sarcoidosis / Q000150:complications* / Q000175:diagnosis
chemical_list: D050034:Antidiuretic Agents; D003894:Deamino Arginine Vasopressin