Inverse correlation between tumor perfusion and glucose uptake in human head and neck tumors.
OBJECTIVE
We sought to determine the relationship between tumor blood flow and glucose uptake in head and neck tumors using perfusion computed tomography (PCT) and fluorine-18-fluorodeoxyglucose (FDG) positron emission tomography (PET).


METHODS
Institutional review board approval and informed consent were obtained for this study. Sixteen patients (mean age, 67 years; age range, 36-89 years) who had known or suspected head and neck tumors (15 malignant tumors and one schwannoma) underwent PCT and FDG PET examinations. Tumor area was measured on conventional CT images. The PCT data were postprocessed using maximum slope method analysis, and standardized uptake value (SUV) was measured on FDG PET.


RESULTS
Mean arterial perfusion of the tumors was 61.56 mL/min/100 mL (range 22.17-102.7 mL/min/100 mL), and mean FDG SUV was 7.48 (range 2.74-17.1). A significant negative correlation between arterial perfusion and FDG SUV was found for malignant tumors (r = -0.538, P = .04, n = 15).


CONCLUSIONS
There was an inverse relationship between arterial perfusion and glucose uptake of head and neck malignant tumors, suggesting that the malignant tumors may depend on anaerobic glycolysis.
Hirasawa
Satoshi
S
Department of Diagnostic and Interventional Radiology, Gunma Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma 371-8511, Japan. hrsw@aurora.dti.ne.jp
Tsushima
Yoshito
Y
Takei
Hiroyuki
H
Hirasawa
Hiromi
H
Taketomi-Takahashi
Ayako
A
Takano
Akie
A
Oriuchi
Noboru
N
Endo
Keigo
K
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D019788:Fluorodeoxyglucose F18; D005947:Glucose / Q000378:metabolism*; D006258:Head and Neck Neoplasms / Q000098:blood supply* / Q000175:diagnosis / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D014057:Tomography, X-Ray Computed
D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D005947:Glucose