title: Value of cytology in papillary condylomatous lesions of the cervix.
abstract: OBJECTIVE
  To determine the value of cytology in detecting mature and immature papillary condylomas of the uterine cervix.
  
  
  METHODS
  We evaluated 240 cases of plane cervical intraepithelial neoplasia, grade 1 (CIN 1), and 23 papillary condylomas by Pap smear and biopsy and classified histologic sections according to maturity and keratinization. We reevaluated corresponding cytologic smears and identified criteria of low grade squamous lesion (LSIL) and human papillomavirus (HPV) infection.
  
  
  RESULTS
  Thirteen (56.5%) papillary lesions were histologically classified as mature, 6 (26%) as immature and 4 (17.3%) as mixed. Fifteen lesions (65.2%) were nonkeratinized, 2 (8.6%) keratinized and 6 (26%) partially keratinized. Corresponding smears were cytologically diagnosed as LSIL (6, 26%), atypical squamous cells of undetermined significance (ASCUS) (7, 30.4%) and negative (10, 43.4%). Careful cytologic review diagnosed only two of the 13 mature lesions; few cytological criteria of LSIL and HPV infection were observed. Koilocytes were seen in just 1 case. Sample limiting factors occurred in 4 cases: 2 cytologically diagnosed as LSIL, 1 asASCUS and 1 as negative for lesion.
  
  
  CONCLUSIONS
  Cytology was not effective in the detection of cervical condyloma acuminatum, independent of limitations in sample adequacy and of the degree of maturity or keratinization of the lesions.
authors.affiliation: Department of Pathology, Hospital de Clínicas, Universidade Federal do Paraná, Brazil. alvaropi@bsi.com.br
authors.forename: Alvaro Piazzetta
authors.initials: AP
authors.lastname: Pinto
authors.forename: Maria Cristina
authors.initials: MC
authors.lastname: Carvalho
authors.forename: Suzane
authors.initials: S
authors.lastname: Kolb
authors.forename: Fábio Antônio
authors.initials: FA
authors.lastname: Tirone
authors.forename: Luis Roberto
authors.initials: LR
authors.lastname: Maia
authors.forename: Cátia Silene
authors.initials: CS
authors.lastname: Escobar
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D003218:Condylomata Acuminata / Q000175:diagnosis* / Q000473:pathology; D005260:Female; D006801:Humans; D008875:Middle Aged; D065006:Papanicolaou Test; D012680:Sensitivity and Specificity; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis* / Q000473:pathology; D014626:Vaginal Smears; D002578:Uterine Cervical Dysplasia / Q000175:diagnosis / Q000473:pathology