title: Neuritogenic activity of gangliosides from echinoderms and their structure-activity relationship.
abstract: The effects of the gangliosides isolated from echinoderms on the neuritogenesis of a rat pheochromocytoma cell line (PC-12 cells) in the presence of nerve growth factor were investigated. The results show that they displayed neuritogenic activity. Based on the observed results, a structure-activity relationship has been established.
authors.affiliation: Faculty of Pharmaceutical Sciences, Kyushu University, Maidashi, Fukuoka, Japan.
authors.forename: Masafumi
authors.initials: M
authors.lastname: Kaneko
authors.forename: Koji
authors.initials: K
authors.lastname: Yamada
authors.forename: Tomofumi
authors.initials: T
authors.lastname: Miyamoto
authors.forename: Masanori
authors.initials: M
authors.lastname: Inagaki
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Higuchi
mesh_terms: D000818:Animals; D004447:Echinodermata / Q000737:chemistry*; D005732:Gangliosides / Q000737:chemistry* / Q000494:pharmacology*; D015394:Molecular Structure; D020932:Nerve Growth Factor / Q000494:pharmacology; D016716:PC12 Cells; D010673:Pheochromocytoma / Q000188:drug therapy; D051381:Rats; D013329:Structure-Activity Relationship
chemical_list: D005732:Gangliosides; D020932:Nerve Growth Factor