Expression of the breast differentiation antigen NY-BR-1 in a phyllodes tumor of the vulva.
We describe a phyllodes tumor of borderline malignancy in the labium majus of a 49-year-old woman. The histogenetic origin of phyllodes tumors in the vulva is controversial. Strong immunoreactivity for NY-BR-1, a novel breast differentiation antigen, was demonstrated within the epithelial components of the phyllodes tumor. A similar expression pattern was observed in mammary-like glands of the vulva. These findings provide further evidence that phyllodes tumors of the vulva might derive from mammary-like glands in the labium majus or from ectopic breast tissue.
Giger
Olivier T
OT
Institute of Surgical Pathology, University Hospital of Zurich, Schmelzbergstrasse 12, CH 8091, Zurich, Switzerland. Olivier.giger@hispeed.ch
Lacoste
Elena
E
Honegger
Christoph
C
Padberg
Barbara
B
Moch
Holger
H
Varga
Zsuzsanna
Z
D000951:Antigens, Neoplasm / Q000032:analysis*; D001940:Breast; D002828:Choristoma / Q000378:metabolism / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D003557:Phyllodes Tumor / Q000378:metabolism / Q000473:pathology*; D014846:Vulvar Neoplasms / Q000378:metabolism / Q000473:pathology*
C509866:ANKRD30A protein, human; D000951:Antigens, Neoplasm