Beyond the sequence: cellular organization of genome function.
Genomes are more than linear sequences. In vivo they exist as elaborate physical structures, and their functional properties are strongly determined by their cellular organization. I discuss here the functional relevance of spatial and temporal genome organization at three hierarchical levels: the organization of nuclear processes, the higher-order organization of the chromatin fiber, and the spatial arrangement of genomes within the cell nucleus. Recent insights into the cell biology of genomes have overturned long-held dogmas and have led to new models for many essential cellular processes, including gene expression and genome stability.
Misteli
Tom
T
National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. mistelit@mail.nih.gov
D000818:Animals; D002451:Cell Compartmentation; D002467:Cell Nucleus / Q000235:genetics*; D002843:Chromatin / Q000235:genetics*; D044127:Epigenesis, Genetic / Q000235:genetics; D005786:Gene Expression Regulation / Q000235:genetics*; D016678:Genome / Q000235:genetics*; D042822:Genomic Instability / Q000235:genetics*; D006801:Humans; D013269:Stochastic Processes
D002843:Chromatin