Treatment of severe cutaneous ulcerative lichen planus with low molecular weight heparin in a patient with hepatitis C.
The ulcerative variant of lichen planus (LP) commonly involves the oral mucosa but is uncommon and difficult to treat when located on other areas. We describe an unusual case of ulcerative LP involving several surfaces, including the palms and scrotum, in a 50-year-old man with hepatitis C. The patient was recalcitrant to treatment with conventional therapy but obtained clearance with a sustained response using low molecular weight heparin (LMWH). This treatment is an option for patients with LP who are not ideal candidates for standard therapy.
Neville
Julie A
JA
Department of Dermatology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157-1071, USA.
Hancox
John G
JG
Williford
Phillip M
PM
Yosipovitch
Gil
G
D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000925:Anticoagulants / Q000627:therapeutic use*; D002990:Clobetasol / Q000627:therapeutic use; D005832:Genital Diseases, Male / Q000188:drug therapy; D006229:Hand Dermatoses / Q000188:drug therapy; D006495:Heparin, Low-Molecular-Weight / Q000627:therapeutic use*; D006526:Hepatitis C / Q000150:complications*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008010:Lichen Planus / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D012611:Scrotum / Q000473:pathology; D012883:Skin Ulcer / Q000188:drug therapy*; D016559:Tacrolimus / Q000627:therapeutic use
D000893:Anti-Inflammatory Agents; D000925:Anticoagulants; D006495:Heparin, Low-Molecular-Weight; D007166:Immunosuppressive Agents; D002990:Clobetasol; D016559:Tacrolimus