Papillomavirus-associated basosquamous carcinoma in an Egyptian fruit bat (Rousettus aegyptiacus).
A 5-yr-old female Egyptian fruit bat (Rousettus aegyptiacus) had a small raised pigmented mass removed from the lateral canthus of the left eye. Six additional variably sized, raised, smooth to cauliflower-like skin masses were observed randomly distributed throughout the left wing membranes. Four masses were removed and diagnosed microscopically as basosquamous carcinomas and papillomas. Additional masses, removed 6 mo and 1 yr later, showed bony invasion and squamous differentiation. Immunohistochemistry detected positive intranuclear staining for bovine papillomavirus antibody in all samples. Polymerase chain reaction done on DNA extracts from formalin-fixed, paraffin-embedded tumor tissue amplified a 450 base-pair segment analogous to the L1 region of human papillomavirus types 96 and 5. Basic Local Alignment Search Tool analysis of sequenced amplicons suggests a novel chiropteran papillomavirus. To our knowledge, this is the first report of papillomavirus-associated carcinoma in a chiropteran species.
McKnight
Christy A
CA
Diagnostic Centers for Population and Animal Health, Michigan State University, 4125 Beaumont Road, Lansing, Michigan 48910, USA.
Wise
Annabel G
AG
Maes
Roger K
RK
Howe
Christopher
C
Rector
Annabel
A
Van Ranst
Marc
M
Kiupel
Matti
M
D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000601:surgery / Q000662:veterinary* / Q000821:virology; D002685:Chiroptera / Q000821:virology*; D005260:Female; D027383:Papillomaviridae / Q000145:classification / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000175:diagnosis / Q000601:surgery / Q000662:veterinary* / Q000821:virology; D012878:Skin Neoplasms / Q000175:diagnosis / Q000601:surgery / Q000662:veterinary* / Q000821:virology