Antitubercular dihydroagarofuranoid sesquiterpenes from the roots of Microtropis fokienensis.
Four new dihydroagarofuranoid sesquiterpenes (1-4) and a new hydroxybenzylsalicylaldehyde, forkienin (5), together with nine known compounds have been isolated from the roots of Microtropis fokienensis. The structures of the new compounds were determined through analyses of physical data. Compounds 3, 4, 7, and 8 exhibited potent antitubercular activities (MICs < or = 26.0 microM) against Mycobacterium tuberculosis 90-221387 in vitro.
Chen
Jih-Jung
JJ
Graduate Institute of Pharmaceutical Technology, Tajen University, Pingtung 907, Taiwan, Republic of China. jjchen@mail.tajen.edu.tw
Chou
Tsung-Hsien
TH
Peng
Chien-Fang
CF
Chen
Ih-Sheng
IS
Yang
Sheng-Zehn
SZ
D000995:Antitubercular Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D029753:Celastraceae / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D013624:Taiwan
D000995:Antitubercular Agents; D012717:Sesquiterpenes