Hypoglycemic coma secondary to big insulin-like growth factor II secretion by a giant phyllodes tumor of the breast.
Nonislet cell tumor hypoglycemia (NICTH) is uncommon, and has been related to the production of insulin-like growth factor II or its high-molecular-weight precursor (big IGF-II) by the tumor. Cases of NICTH have been related to different tumors, mainly sarcomas. However, only three cases secondary to a phyllodes tumor of the breast (PTB) have been previously reported. We present the clinical course of a woman with a giant PTB, who developed an irreversible hypoglycemic coma secondary to big IGF-II production by the tumor. A brief review of the literature and possible mechanisms of this infrequent condition are also commented.
Aguiar Bujanda
David
D
Servicio de Oncología Médica, Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, Spain. dagubuj@gobiernodecanarias.org
Rivero Vera
José Carlos
JC
Cabrera Suárez
Miguel Angel
MA
Aguiar Morales
José
J
Christol
Rémy
R
Bohn Sarmiento
Uriel
U
Domínguez Cabrera
Casimira
C
Le Bouc
Yves
Y
D001943:Breast Neoplasms / Q000378:metabolism*; D003128:Coma / Q000209:etiology*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007003:Hypoglycemia / Q000209:etiology*; D007335:Insulin-Like Growth Factor II / Q000378:metabolism*; D008875:Middle Aged; D003557:Phyllodes Tumor / Q000378:metabolism*; D011498:Protein Precursors / Q000378:metabolism*
D011498:Protein Precursors; C066038:proinsulin-like growth factor II; D007335:Insulin-Like Growth Factor II