title: Prorenin levels in retinopathy of prematurity.
abstract: OBJECTIVE
  To evaluate serum prorenin levels in preterm infants with or without retinopathy of prematurity (ROP).
  
  
  METHODS
  Noncomparative retrospective case control study.
  
  
  METHODS
  Serum prorenin levels in children with a gestational age younger than 36 weeks were measured with antibody-activating direct enzyme kinetic assay.
  
  
  RESULTS
  The mean prorenin concentrations were higher in preterm infants with ROP than in infants without ROP at every time point: from 26 to 30 weeks, 2326 +/- 334 microg/ml (mean +/- SE [standard error]) (n = 3) and 1164 +/- 234 microg/ml (n = 3), respectively (P < .05); from 31 to 35 weeks, 1760 +/- 496 microg/ml (n = 10) and 957.1 +/- 139 microg/ml (n = 25) (P < .05); from 36 to 40 weeks, 958.2 +/- 194.2 microg/ml (n = 23) and 470.1 +/- 32.6 microg/ml (n = 67) (P < .01); and from 41 to 45 weeks, 575.8 +/- 148.4 (n = 9) and 385.6 +/- 47.9 (n = 13), which is not significantly different.
  
  
  CONCLUSIONS
  Prorenin levels in preterm infants can predict which infants will develop ROP.
authors.affiliation: Department of Ophthalmology, Asahikawa Medical College, Asahikawa, Japan. atokyo18@mac.com
authors.forename: Harumasa
authors.initials: H
authors.lastname: Yokota
authors.forename: Taiji
authors.initials: T
authors.lastname: Nagaoka
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Mori
authors.forename: Taiichi
authors.initials: T
authors.lastname: Hikichi
authors.forename: Hiromichi
authors.initials: H
authors.lastname: Hosokawa
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Tanaka
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Ishida
authors.forename: Fumiaki
authors.initials: F
authors.lastname: Suzuki
authors.forename: Akitoshi
authors.initials: A
authors.lastname: Yoshida
mesh_terms: D016022:Case-Control Studies; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000097:blood; D012083:Renin / Q000097:blood*; D012178:Retinopathy of Prematurity / Q000097:blood* / Q000145:classification; D012189:Retrospective Studies
chemical_list: D012083:Renin