Pattern of factor VIII inhibitors in patients with hemophilia A in the north east of Iran.
This survey was conducted to evaluate coagulation factor VIII:C inhibitors among 102 hemophilia A patients from different cities of Khorasan province in north east of Iran in order to identify and characterize the pattern of inhibitor formation in these patients population. For this purpose, we randomly obtained plasma samples of 102 hemophilia A patients (44 patients with severe, 28 patients with intermediate and 30 patients with mild hemophilia A) and studied them using two tests: the APTT mix and Bethesda test were performed. In the whole group 20 patients (19.6%) factor VIII inhibitors were detected. These were in 11 patients with severe, five patients with intermediate and four patients with mild hemophilia A. None of patients with hemophilia A had previously been studied for the presence of an inhibitor, so there was no existing history of inhibitor evaluation.
Modaresi
A R
AR
Pediatric Hematology Group, Dr Sheikh Hospital, Mashad, Iran. modarresi27@yahoo.com
Torghabeh
H Mansouri
HM
Pourfathollah
A A
AA
Shooshtari
M Mahmoodian
MM
Yazdi
Z Rezaie
ZR
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000918:Antibody Specificity; D001780:Blood Coagulation Tests; D002648:Child; D002675:Child, Preschool; D005169:Factor VIII / Q000276:immunology* / Q000627:therapeutic use; D005260:Female; D006467:Hemophilia A / Q000453:epidemiology / Q000276:immunology*; D006801:Humans; D007492:Iran / Q000453:epidemiology; D007518:Isoantibodies / Q000096:biosynthesis / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D010314:Partial Thromboplastin Time; D012494:Sampling Studies
D007518:Isoantibodies; D005169:Factor VIII