Actinic cheilitis adjacent to squamous carcinoma of the lips as an indicator of prognosis.
Many studies have shown an association between actinic cheilitis and squamous carcinoma of the lips.


OBJECTIVE
The aim of the study was to observe the relation between actinic cheilitis and the prognosis of squamous carcinoma of the lips. MATERIALS AND METHODS This is a retrospective cross-sectional cohort study of squamous carcinoma of the lips. Histological sections of squamous carcinoma tumors done at the the Department of Pathology of the Sao Paulo Federal University between 1993 and 2000 were reviewed for evidence of actinic cheilitis in the lip vermillion adjacent to the tumor. Patient reports were reviewed to find information about exposure to sun, metastases and relapses. The occurrence or absence of relapses and metastases was correlated with the presence or absence of actinic cheilitis in the lip vermillion. Data was analyzed by Fisher's Exact test.


RESULTS
Of the 31 selected patients, most were caucasian, males and with lower lip involvement. Statistical analysis demonstrated independence between the occurrence of metastases and relapse and gender, skin color and site (lower or upper lips). There was dependence between actinic cheilitis and solar elastosis, and between the absence of actinic cheilitis and the occurrence of metastases. There was no dependence between the absence of actinic cheilitis and the occurrence of relapses.


CONCLUSIONS
It may be concluded that tumors originating from actinic cheilitis have a better prognosis.
Abreu
Marilda Aparecida Milanez Morgado de
MA
Setor de Estomatologia, Departamentos de Dermatologia e Otorrinolaringologia e Distúrbios da Comunicação Humana, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP. lfmabreu@uol.com.br
Silva
Olga Maria Panhoca da
OM
Neto Pimentel
Dalva Regina
DR
Hirata
Cleonice Hitomi Watashi
CH
Weckx
Luc Louis Maurice
LL
Alchorne
Mauricio Mota de Avelar
MM
Michalany
Nilceo Shwery
NS
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000150:complications* / Q000473:pathology; D002613:Cheilitis / Q000150:complications* / Q000473:pathology; D002908:Chronic Disease; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008048:Lip Neoplasms / Q000150:complications* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local; D011379:Prognosis; D012189:Retrospective Studies