title: IL-10 genotype analysis in patients with Behçet's disease.
abstract: Behçet's disease (BD) is a multisystem inflammatory disease characterized by recurrent orogenital ulceration, ocular inflammation, and skin lesions. The etiology of the disease is currently unknown but evidence suggests that there is a strong genetic component mediating the chronicity of the disorder. We have examined the association between polymorphisms at position -1082, and -819 in the promoter region of the gene encoding IL-10 in patients with Behçet's disease from two distinct patient populations. The IL-10 -1082AA genotype was weakly associated with BD when all patients were analyzed as a group (pc = 0.04, OR 1.4, 95% CI 1.1-1.9), but not in the UK or Middle Eastern (ME) cohorts of patients alone compared to local controls. An association with IL-10 -819T was evident in all BD patients, (pc = 0.02, OR 1.5, 95% CI 1.1-2.0), and this was because of an association in the UK but not ME patients (pc = 0.0004, OR 2.1, 95% CI 1.4-3.3). The -1082A/-819T haplotype, which is linked to low production of this cytokine, was not significantly associated with Behçet's disease. This link between BD, a chronic, relapsing, autoinflammatory condition, and a genotype associated with low IL-10 production provides evidence that abnormalities in the genetic control of cytokine levels may be relevant in influencing the immune response in Behçet's disease in some patient groups.
authors.affiliation: Academic Unit of Ophthalmology, University of Birmingham, Birmingham, United Kingdom. g.r.wallace@bham.ac.uk
authors.forename: Graham R
authors.initials: GR
authors.lastname: Wallace
authors.forename: Elly
authors.initials: E
authors.lastname: Kondeatis
authors.forename: Robert W
authors.initials: RW
authors.lastname: Vaughan
authors.forename: David H
authors.initials: DH
authors.lastname: Verity
authors.forename: Yuanneng
authors.initials: Y
authors.lastname: Chen
authors.forename: Farida
authors.initials: F
authors.lastname: Fortune
authors.forename: Wafa
authors.initials: W
authors.lastname: Madanat
authors.forename: Charlie A
authors.initials: CA
authors.lastname: Kanawati
authors.forename: Elizabeth M
authors.initials: EM
authors.lastname: Graham
authors.forename: Miles R
authors.initials: MR
authors.lastname: Stanford
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D018912:Arabs; D001528:Behcet Syndrome / Q000208:ethnology* / Q000235:genetics / Q000276:immunology; D005260:Female; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D008877:Middle East; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic; D006113:United Kingdom; D044465:White People
chemical_list: D016753:Interleukin-10