title: The influence of the timing of cord clamping on postnatal cerebral oxygenation in preterm neonates: a randomized, controlled trial.
abstract: OBJECTIVE
  Our goal was to investigate the effect of placentofetal transfusion on cerebral oxygenation in preterm infants by near-infrared spectroscopy.
  
  
  METHODS
  A total of 39 preterm infants with a median gestational age of 30.4 weeks were randomly assigned to an experiment group (n = 15) and a control group (n = 24).
  
  
  METHODS
  The delivery of the infants in the experiment group was immediately followed by maternal administration of syntocinon, the infant was placed 15 cm below the placenta, and cord clamping was delayed by 60 to 90 seconds. The infants in the control group were delivered conventionally. At the ages of 4 and 24 hours, cerebral hemoglobin concentrations, cerebral blood volume, and regional tissue oxygenation were measured by near-infrared spectroscopy.
  
  
  RESULTS
  Cerebral blood volume was not different between the 2 groups at the age of 4 hours (6.1 vs 5.8 mL/100 g of tissue) nor at the age of 24 hours (6.2 vs 6.2 mL/100 g of tissue). Mean regional tissue oxygenation of the experiment group was higher at the ages of 4 hours (69.9% vs 65.5%) and of 24 hours (71.3% vs 68.1%).
  
  
  CONCLUSIONS
  Delayed clamping of the umbilical cord improves cerebral oxygenation in preterm infants in the first 24 hours.
authors.affiliation: Department of Neonatology, University Hospital Zurich, Zurich, Switzerland. oskar.baenziger@kispi.unizh.ch
authors.forename: Oskar
authors.initials: O
authors.lastname: Baenziger
authors.forename: Florian
authors.initials: F
authors.lastname: Stolkin
authors.forename: Mathias
authors.initials: M
authors.lastname: Keel
authors.forename: Kurt
authors.initials: K
authors.lastname: von Siebenthal
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Fauchere
authors.forename: Seema
authors.initials: S
authors.lastname: Das Kundu
authors.forename: Vera
authors.initials: V
authors.lastname: Dietz
authors.forename: Hans-Ulrich
authors.initials: HU
authors.lastname: Bucher
authors.forename: Martin
authors.initials: M
authors.lastname: Wolf
mesh_terms: D001794:Blood Pressure; D002560:Cerebrovascular Circulation / Q000502:physiology*; D003250:Constriction; D036861:Delivery, Obstetric / Q000379:methods*; D005260:Female; D006400:Hematocrit; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000502:physiology*; D010100:Oxygen / Q000378:metabolism*; D021041:Placental Circulation / Q000502:physiology; D011247:Pregnancy; D019265:Spectroscopy, Near-Infrared; D013687:Telencephalon / Q000378:metabolism*; D013997:Time Factors; D014470:Umbilical Cord
chemical_list: D010100:Oxygen