title: Factors predictive for long-term survival of male patients with hepatocellular carcinoma after curative resection.
abstract: OBJECTIVE
  Curative hepatic resection (CHR) was a modality that provides possibility of long-term survival for hepatocellular carcinoma (HCC). So far, prognostic factors of male patients with HCC after CHR remain unclear. Purposes of the present study were to identify these factors and to compare them with those for females.
  
  
  METHODS
  Consecutive 151 male and 23 female patients with HCC undergoing CHR were enrolled in this retrospective study. Their prognostic factors were identified by uni- and multi-variate statistical analysis.
  
  
  RESULTS
  One-, three- and five-year overall and disease-free survival of male patients were 82.4, 51.5, and 43.6%, and 65.8, 33.7, and 21.7%, respectively, with no significant differences compared to females. Univariate analysis showed that tumor size, TNM staging, Edmondson-Steiner grade, serum alpha-fetoprotein (AFP) level, presence of portal vein tumor thrombosis (PVTT) and satellite nodule were significant for males with HCC, but only Edmondson-Steiner grade, presence of PVTT and satellite nodule were independent. For females, Edmondson-Steiner grade was the single potential indicator for survival.
  
  
  CONCLUSIONS
  Malignant degree and invasive phenotypes were main factors that independently influenced survival of male patients with HCC after CHR. Among them, histological grade, which was also potentially significant for females, was the most powerful survival predictor.
authors.affiliation: Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences/Peking Union Medical College, Beijing, China.
authors.forename: Li
authors.initials: L
authors.lastname: Zhou
authors.forename: Jing-An
authors.initials: JA
authors.lastname: Rui
authors.forename: Shao-Bin
authors.initials: SB
authors.lastname: Wang
authors.forename: Shu-Guang
authors.initials: SG
authors.lastname: Chen
authors.forename: Qiang
authors.initials: Q
authors.lastname: Qu
authors.forename: Tian-Yi
authors.initials: TY
authors.lastname: Chi
authors.forename: Xue
authors.initials: X
authors.lastname: Wei
authors.forename: Kai
authors.initials: K
authors.lastname: Han
authors.forename: Ning
authors.initials: N
authors.lastname: Zhang
authors.forename: Hai-Tao
authors.initials: HT
authors.lastname: Zhao
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000401:mortality* / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006498:Hepatectomy / Q000401:mortality*; D006801:Humans; D008113:Liver Neoplasms / Q000401:mortality* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D011169:Portal Vein / Q000473:pathology; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate; D020246:Venous Thrombosis / Q000473:pathology; D000509:alpha-Fetoproteins / Q000378:metabolism
chemical_list: D000509:alpha-Fetoproteins