[Dynamics of Fatty Acid binding protein and pro-brain natriuretic Peptide levels in patients with ischemic heart disease at the background of stress test and balloon coronary angioplasty.].
Dynamics of fatty acid binding protein (FABP) and pro-brain natriuretic peptide (pro-BNP) levels was studied in patients with ischemic heart disease at rest, during transitory myocardial ischemia, and before and after balloon angioplasty. Forty patients were included: 25 patients with stable angina comprised the study group and 15 patients with acute myocardial infarction (AMI) comprised control group. No significant elevation of FABP was revealed after myocardial revascularization, a tendency was noted to elevation of FABP after transitory ischemia. At the background of stress test pro-BNP level significantly rose. Comparison of FABP levels during first 24 hours of AMI and in patients with IHD both at rest and after veloergometry showed that FABP level in AMI was significantly higher. On day 21 of AMI FABP level became lower and did not differ significantly from this parameter in patients with IHD. Data of this work confirm that search of markers of myocardial ischemia in peripheral blood of patients with IHD is justified, and investigation of their role can allow not only to elevate diagnostic value of stress test, but to assess prognosis and to supplement algorithm of examination of patients with suspected IHD.
Sergienko
I B
IB
A.L. Myasnikov Institute of Clinical Cardiology; ul. Tretiya Cherepkovskaya, 15a, 121552 Moscow, Russia.
Masenko
V P
VP
Semenova
A E
AE
Khabibullina
L I
LI
Gabrusenko
S A
SA
Belenkov
Iu N
IuN
D015906:Angioplasty, Balloon, Coronary; D005080:Exercise Test; D050556:Fatty Acid-Binding Proteins; D006801:Humans; D017202:Myocardial Ischemia / Q000175:diagnosis; D020097:Natriuretic Peptide, Brain / Q000097:blood
D050556:Fatty Acid-Binding Proteins; D020097:Natriuretic Peptide, Brain