New C-3' hydroxamate-substituted and more lipophilic cyclic hydroxamate cephalosporin derivatives as a potential new generation of selective antimicrobial agents.
Miller
Marvin J
MJ
Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA. mmiller1@nd.edu
Zhao
Gaiying
G
Vakulenko
Sergei
S
Franzblau
Scott
S
Möllmann
Ute
U
D000818:Animals; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001412:Bacillus subtilis / Q000187:drug effects*; D002511:Cephalosporins / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D002522:Chlorocebus aethiops; D003500:Cyclization; D006877:Hydroxamic Acids / Q000737:chemistry; D008826:Microbial Sensitivity Tests; D016982:Micrococcus luteus / Q000187:drug effects*; D008968:Molecular Conformation; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D013211:Staphylococcus aureus / Q000187:drug effects*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D014709:Vero Cells / Q000187:drug effects
D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D006877:Hydroxamic Acids