Hemostatic changes in thyroid diseases: haemostasis and thrombosis.
Several studies have reported hemostatic abnormalities, both in terms of bleeding or thrombosis, in patients with various thyroid dysfunctions. The aim of this review is to briefly discuss the relationship between thyroid disorders and hemostasis (i.e. primary hemostasis, coagulation factors and fibrinolytic system). From the analysis of the more recent literature data, it appears evident that most of the coagulation abnormalities associated with thyroid disorders are a consequence of a direct action of thyroid hormones on the synthesis of various hemostatic factors or a derangement of immune function. On the whole, these data suggest that a hypercoagulable state is present in hyperthyroid patients, while patients suffering from moderate hypothyroidism are at increased risk of thrombosis contrasting with the bleeding tendency of those presenting severe hypothyroidism.
Franchini
Massimo
M
Servizio di Immunoematologia e Trasfusione-Centro Emofilia, Azienda Ospedaliera di Verona, Verona, Italy. massimo.franchini@azosp.vr.it
D001778:Blood Coagulation Disorders / Q000097:blood / Q000209:etiology*; D001779:Blood Coagulation Factors / Q000096:biosynthesis; D006474:Hemorrhagic Disorders / Q000097:blood / Q000209:etiology; D006487:Hemostasis; D006801:Humans; D006980:Hyperthyroidism / Q000097:blood / Q000150:complications; D007037:Hypothyroidism / Q000097:blood / Q000150:complications; D019851:Thrombophilia / Q000097:blood / Q000209:etiology; D013959:Thyroid Diseases / Q000097:blood / Q000150:complications*; D013963:Thyroid Hormones / Q000502:physiology; D013964:Thyroid Neoplasms / Q000097:blood / Q000150:complications; D014842:von Willebrand Diseases / Q000097:blood / Q000209:etiology
D001779:Blood Coagulation Factors; D013963:Thyroid Hormones