2'-hydroxy-fendiline analogues as potent relaxers of isolated arteries.
Novel, 2'-hydroxy derivatives of fendiline have been synthesised and their ability to induce relaxation of isolated rat small mesenteric and coronary arteries were determined. Both derivatives examined were significantly more potent as vasodilators than fendiline itself. Similar effects were observed on both mesenteric and coronary arteries.
Wilkinson
James
J
Centre for Drug Design, Biosciences Research Institute, Cockcroft Building, University of Salford, Salford M5 4WT, UK. j.a.wilkinson@salford.ac.uk
Foretia
Dennis
D
Rossington
Steven
S
Heagerty
Anthony
A
Leonard
John
J
Hussain
Nigel
N
Austin
Clare
C
D000818:Animals; D001158:Arteries; D003331:Coronary Vessels / Q000187:drug effects* / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D005275:Fendiline / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology*; D008297:Male; D008638:Mesenteric Arteries / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013329:Structure-Activity Relationship; D014661:Vasoconstriction / Q000187:drug effects; D014665:Vasodilator Agents / Q000138:chemical synthesis / Q000494:pharmacology*
D014665:Vasodilator Agents; D005275:Fendiline