title: New lesions on the knees with palmoplantar keratoderma.
abstract: A 40-year-old Latin American woman presented for evaluation with a 5-week history of redness, thickened skin, and itching of the knees, as well as persistent redness and thickened skin of the palms and soles consistent with Papillon-Lefèvre syndrome (PLS). The article discusses the clinical presentation and treatment of PLS.
authors.affiliation: Harvard University Medical School, Boston, Massachusetts, USA.
authors.forename: Kjetil Kristoffer
authors.initials: KK
authors.lastname: Guldbakke
authors.forename: Claudia
authors.initials: C
authors.lastname: Millina
authors.forename: Trevor R
authors.initials: TR
authors.lastname: Thompson
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007645:Keratoderma, Palmoplantar / Q000175:diagnosis*; D007641:Keratolytic Agents / Q000627:therapeutic use; D007717:Knee / Q000473:pathology*; D007868:Leg Dermatoses / Q000175:diagnosis*; D009539:Nicotinic Acids / Q000627:therapeutic use; D010214:Papillon-Lefevre Disease / Q000175:diagnosis*; D011355:Prodrugs / Q000627:therapeutic use; D012176:Retinoids / Q000627:therapeutic use; D014508:Urea / Q000627:therapeutic use
chemical_list: D007641:Keratolytic Agents; D009539:Nicotinic Acids; D011355:Prodrugs; D012176:Retinoids; C086827:tazarotene; D014508:Urea