title: Usefulness of ambulatory blood pressure monitoring in predicting the presence of autonomic neuropathy in type I diabetic patients.
abstract: This study investigated whether nondipping (defined as a day-night change in blood pressure (BP) <or=0%) could be assumed as a diagnostic index for autonomic neuropathy, and assessed its accuracy in discriminating between type I diabetic patients with and without autonomic neuropathy. In 87 type I diabetic patients with normal renal function (age 36+/-11, duration 17+/-9 years, serum creatinine 67.2+/-15.9 micromol/l), four cardiovascular tests and 24-h BP monitoring were performed, and the percentage day-night change (Delta) in systolic (SBP) and diastolic BP (DBP) was calculated. Sixteen patients had DeltaSBP and/or DeltaDBP <or=0%. In a multiple logistic regression with adjustment for sex, age, and body mass index, the odds ratio for having autonomic neuropathy was seven times higher in patients with DeltaSBP <or=0% as opposed to those without (odds ratio 6.97, CI 1.4-34.9, P=0.018). Using Receiver Operating Characteristic (ROC) analysis, DeltaBP showed an acceptable accuracy in discriminating between patients with and without autonomic neuropathy (area under the ROC curve 0.69+/-0.06 and 0.72+/-0.05 for DeltaSBP and DeltaDBP, respectively). Adequate cutoff values were 0% for DeltaSBP (sensitivity, 26%; specificity, 95%; positive predictive value, 87%) and 5% for DeltaDBP (sensitivity, 26%; specificity, 92%; positive predictive value, 81%). In type I diabetic patients with normal renal function, a value of DeltaSBP <or=0% identifies the presence of autonomic neuropathy with a very high chance. Nondipping at the cutoff proposed could be considered an adjunctive marker of autonomic neuropathy provided with a high specificity and low sensitivity.
authors.affiliation: Department of Internal Medicine, Endocrinology, Tor Vergata University, Rome, Italy. vispa@mclink.it
authors.forename: V
authors.initials: V
authors.lastname: Spallone
authors.forename: M R
authors.initials: MR
authors.lastname: Maiello
authors.forename: R
authors.initials: R
authors.lastname: Morganti
authors.forename: S
authors.initials: S
authors.lastname: Mandica
authors.forename: G
authors.initials: G
authors.lastname: Frajese
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001342:Autonomic Nervous System Diseases / Q000503:physiopathology*; D015415:Biomarkers / Q000097:blood / Q000652:urine; D001794:Blood Pressure; D018660:Blood Pressure Monitoring, Ambulatory; D016022:Case-Control Studies; D002940:Circadian Rhythm; D003922:Diabetes Mellitus, Type 1 / Q000503:physiopathology*; D003929:Diabetic Neuropathies / Q000503:physiopathology*; D005260:Female; D006801:Humans; D016014:Linear Models; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012372:ROC Curve; D012384:Rome
chemical_list: D015415:Biomarkers