title: Paraneoplastic diseases associated with thymoma.
abstract: BACKGROUND
  Thymoma is frequently associated with paraneoplastic diseases (PDs), most commonly with myasthenia gravis (MG). This association is thought to depend on thymoma's capacity to produce and export T lymphocytes.
  
  
  OBJECTIVE
  (1) To determine the frequency and characteristics of thymoma-associated PDs other than MG; (2) to evaluate T cell maturation in thymomas with and without PDs.
  
  
  METHODS
  We studied 260 patients with thymoma (associated with MG in 228). The occurrence of PDs was monitored together with the tumor outcome. Phenotypic characterization of thymocyte subsets in 14 thymoma samples (7 with and 7 without MG) was performed by FACS.
  
  
  RESULTS
  A total of 47 PDs was diagnosed in 41/260 patients (15.8 %). Neurological PDs included neuromyotonia, limbic encephalitis, polymyositis, subacute hearing loss, psychosis and sleep disorders. A broad spectrum of nonneurological PDs were observed, among these, hematological and cutaneous diseases prevailed. Like MG, these disorders occurred either in the presence of the thymoma or at different times after thymomectomy; their onset often heralded a tumor recurrence. In thymomas from MG subjects, we found an increased proportion of fully mature CD4 single positive (SP) thymocytes and a reduced frequency of CD4SPCD25(+) cells; the latter finding may reflect a deficient generation of T regulatory cells, a reduced intratumorous activation of T cells, or both.
  
  
  CONCLUSIONS
  We confirm the strong association of thymoma with PDs. These disorders often occurred in MG patients and their course in relation to thymoma was similar to that of MG. In accordance with previous observations, we found some alterations in the intratumorous production of mature CD4(+) T cells that could be involved in the pathogenesis of paraneoplastic autoimmunity.
authors.affiliation: Dept. of Neurosciences, Catholic University, Largo F. Vito, 00168 Rome, Italy. a.evoli@rm.unicatt.it
authors.forename: Amelia
authors.initials: A
authors.lastname: Evoli
authors.forename: Giacomo Maria
authors.initials: GM
authors.lastname: Minicuci
authors.forename: Roberta
authors.initials: R
authors.lastname: Vitaliani
authors.forename: Alessandra
authors.initials: A
authors.lastname: Battaglia
authors.forename: Giacomo
authors.initials: G
authors.lastname: Della Marca
authors.forename: Libero
authors.initials: L
authors.lastname: Lauriola
authors.forename: Andrea
authors.initials: A
authors.lastname: Fattorossi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D018791:CD4 Lymphocyte Count; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D002454:Cell Differentiation / Q000276:immunology; D049109:Cell Proliferation; D015897:Comorbidity; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D016130:Immunophenotyping; D016131:Lymphocyte Subsets / Q000166:cytology / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009157:Myasthenia Gravis / Q000453:epidemiology / Q000276:immunology / Q000503:physiopathology; D010257:Paraneoplastic Syndromes / Q000175:diagnosis / Q000453:epidemiology* / Q000276:immunology*; D015995:Prevalence; D011948:Receptors, Antigen, T-Cell / Q000276:immunology; D012189:Retrospective Studies; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology; D013945:Thymoma / Q000453:epidemiology* / Q000276:immunology* / Q000503:physiopathology; D013953:Thymus Neoplasms / Q000453:epidemiology* / Q000276:immunology* / Q000503:physiopathology
chemical_list: D011948:Receptors, Antigen, T-Cell