title: Morphometric study of the ductus arteriosus during human development.
abstract: During prenatal life, the ductus arteriosus connects the left pulmonary artery and the descending aorta. Morphometric features (length, external diameter, volume) of the ductus arteriosus in 131 human fetuses (65 males, 66 females) were studied by means of anatomical, digital and statistical methods. Regression analysis was used to investigate the growth of the ductus arteriosus during gestation. The values of the length of the ductus arteriosus ranged from 3.95 mm for the 15 week gestational group to 12.20 mm for the 34th week of gestation. The length of the ductus arteriosus related to fetal age (x) increased according to the linear function y = -3.0726 + 0.4381x. The mean values of the diameter of the ductus arteriosus ranged from 1.34 to 3.49mm for the 15 and 34 week gestational groups, respectively. The growth of the ductus arteriosus diameter followed in accordance with the linear function y = 0.2072 + 0.0935x. The mean values of the ductus arteriosus volume ranged from 5.08 mm3 for the 15 week group to 117.30 mm3 of the 34 week gestation group. The volume growth increased according to the function y = 0.0007x3.3782. Positive correlation coefficients between arterial parameters and fetal age were statistically significant (P < or = 0.01) and reached the following values: r1 = 0.98 for Length, r2 = 0.90 for diameter and r3 = 0.94 for volume. Despite the increase in absolute diameter, the relative diameter of the ductus arteriosus (ductus arteriosus-to-aortic bulb diameter ratio) decreased from 0.80 to 0.48.
authors.affiliation: Department of Normal Anatomy, Ludwig Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Karłowicza 24 Street, 85-092-Bydgoszcz, Poland. kizanat@cm.umk.pl
authors.forename: Michał
authors.initials: M
authors.lastname: Szpinda
authors.forename: Anna
authors.initials: A
authors.lastname: Szwesta
authors.forename: Emilia
authors.initials: E
authors.lastname: Szpinda
mesh_terms: D004373:Ductus Arteriosus / Q000033:anatomy & histology* / Q000196:embryology*; D005260:Female; D047109:Fetal Development; D005865:Gestational Age; D006801:Humans; D008297:Male; D012044:Regression Analysis