Rapid leptin elevation after initiation of olanzapine?
Weight gain is a common adverse effect associated with olanzapine treatment. Another side effect of olanzapine treatment is a significant increase in circulating leptin levels. This preliminary study monitored the changes in leptin levels for 2 weeks after olanzapine treatment had been initiated. The relationship between the changes in circulating leptin levels and alterations in body weight in 9 patients with schizophrenia who received olanzapine was examined. The results showed that olanzapine may cause a surge in circulating leptin levels before weight gain is manifested. Moreover, higher pretreatment circulating leptin levels predicted lower weight gains after olanzapine treatments (r = -0.93; p < 0.05) after controlling for the effect of sex.
Wang
Hsuan-Chi
HC
Department of Psychiatry, National Cheng Kung University Hospital, Tainan, Taiwan, ROC.
Chen
Po See
PS
Lee
I Hui
IH
Yang
Yen Kuang
YK
Yeh
Tzung Lieh
TL
Lu
Ru-Band
RB
D000208:Acute Disease; D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D001569:Benzodiazepines / Q000627:therapeutic use; D005260:Female; D006801:Humans; D020738:Leptin / Q000097:blood*; D008297:Male; D000077152:Olanzapine; D012559:Schizophrenia / Q000097:blood* / Q000188:drug therapy; D012737:Sex Factors; D015430:Weight Gain / Q000187:drug effects*
D014150:Antipsychotic Agents; D020738:Leptin; D001569:Benzodiazepines; D000077152:Olanzapine