Non-effect of p22-phox -930A/G polymorphism on end-organ damage in Brazilian hypertensive patients.
The p22-phox subunit is an essential component of NAD(P)H oxidase enzymatic complex, which is considered the major source of oxidative stress products in the cardiovascular system. The -930G allele of p22-phox has been associated with higher promoter activity, increased NAD(P)H oxidase-mediated oxidative stress and hypertension. We recently reported that left ventricular hypertrophy is accompanied by increased myocardial p22-phox expression in aortic-banded rats, suggesting that this protein might be involved in hypertensive cardiac hypertrophy.
Sales
M L
ML
Ferreira
M C S
MC
Leme
C A
CA
Velloso
L A
LA
Gallani
M C J
MC
Colombo
R C R
RC
Franchini
K G
KG
Nadruz
W
W
D000328:Adult; D001938:Brazil; D005260:Female; D006801:Humans; D006973:Hypertension / Q000235:genetics* / Q000473:pathology*; D017379:Hypertrophy, Left Ventricular / Q000209:etiology / Q000235:genetics; D007668:Kidney / Q000473:pathology; D008297:Male; D008875:Middle Aged; D019255:NADPH Oxidases / Q000235:genetics*; D018384:Oxidative Stress; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic
D019255:NADPH Oxidases; C086986:CYBA protein, human