Xanthogranuloma of the iris simulating melanoma in an adult.
OBJECTIVE
To report a case in an adult of xanthogranuloma of the iris that clinically simulated iris melanoma.


METHODS
Observational case report.


METHODS
Clinical and histopathologic examination of iris mass obtained from a 77-year-old white woman.


RESULTS
High-frequency ultrasonography of the right eye revealed a small, echodense lesion involving the iris root. The mass revealed histopathologic features identical to juvenile xanthogranuloma (JXG), including histiocytes and lymphocytes mixed with multinucleated giant cells, and eosinophilic leukocytes. The histiocytes stained positive for CD68, CD45, and factor XIIIa and negative for S-100 and CD1a.


CONCLUSIONS
Xanthogranuloma of the iris can occur in elderly patients. Such lesions should be considered in the differential diagnosis of iris melanoma.
Sukavatcharin
Somsiri
S
Doheny Eye Institute and Department of Ophthalmology, Keck School of Medicine of University of Southern California, Los Angeles, California 90033, USA.
Cursino
Sylvia
S
Li
Gisele
G
Green
Ronald L
RL
Lim
Jennifer I
JI
Rao
Narsing A
NA
D000368:Aged; D015415:Biomarkers / Q000378:metabolism; D003937:Diagnosis, Differential; D005260:Female; D006644:Histiocytes / Q000378:metabolism; D006801:Humans; D007499:Iris Diseases / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D008545:Melanoma / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D014463:Ultrasonography; D014972:Xanthogranuloma, Juvenile / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000473:pathology / Q000601:surgery
D015415:Biomarkers