Immunophenotyping of lymphosarcoma in South American camelids on six British premises.
Six cases of lymphosarcoma (LSA) in South American camelids (SACs) were selected from submissions to a diagnostic laboratory network servicing England and Wales. Immunophenotyping was carried out using anti-human CD3 and anti-human CD5 for T-cells; and anti-human CD79a and anti-human CD79b for B-cells/plasma cells. On the basis of labelling with mainly anti-CD3, four of the tumours were classified as T-cell tumours. One case was labelled with anti-CD79a and anti-CD79b, and was classified as a B-cell tumour. In the other case the majority of cells were labelled with anti-CD3, anti-CD79a and anti-CD79b, and was classified as a mixed T- and B-cell tumour. To the authors' knowledge this is the first reported attempt at immunophenotyping LSA in SACs on British premises and is only the second time that a presumptive mixed T- and B-cell LSA has been reported in alpacas and the veterinary literature in general.
Twomey
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DF
Veterinary Laboratories Agency, Staplake Mount, Starcross, Exeter, Devon EX6 8PE, UK. f.twomey@vla.defra.gsi.gov.uk
Barlow
A M
AM
Hemsley
S
S
D000818:Animals; D002162:Camelus; D003937:Diagnosis, Differential; D004739:England; D005260:Female; D016130:Immunophenotyping / Q000662:veterinary; D008228:Lymphoma, Non-Hodgkin / Q000175:diagnosis / Q000662:veterinary*; D008297:Male; D014852:Wales