title: Associations of the plasma interleukin 6 (IL-6) levels with disability and mortality in the elderly in the Treviso Longeva (Trelong) study.
abstract: IL-6 expression is regulated by the interplay of several transcriptional and hormonal factors, including sex steroids and glucocorticoids. In late life IL-6 expression increases as a result from loss of the normally inhibiting sex steroids. IL-6 is one of several proinflammatory cytokines. It has been proposed that many chronic inflammatory diseases are the result of a dysregulation of IL-6 expression. In this work we demonstrate that increased IL-6 levels in elderly are associated with higher disability and mortality, also independently of age and comorbidity.
authors.affiliation: ARGel, Interdisciplinary Geriatric Research Association, Trento Trieste Aven. 19, I-31100 Treviso, Italy. m_gallucci@tin.it <m_gallucci@tin.it>
authors.forename: M
authors.initials: M
authors.lastname: Gallucci
authors.forename: G P
authors.initials: GP
authors.lastname: Amici
authors.forename: F
authors.initials: F
authors.lastname: Ongaro
authors.forename: G B
authors.initials: GB
authors.lastname: Gajo
authors.forename: S
authors.initials: S
authors.lastname: De Angeli
authors.forename: G L
authors.initials: GL
authors.lastname: Forloni
authors.forename: D
authors.initials: D
authors.lastname: Albani
authors.forename: F
authors.initials: F
authors.lastname: Prato
authors.forename: L
authors.initials: L
authors.lastname: Polito
authors.forename: A
authors.initials: A
authors.lastname: Zanardo
authors.forename: C
authors.initials: C
authors.lastname: Regini
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D004185:Disability Evaluation; D005260:Female; D006304:Health Status; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D007558:Italy / Q000453:epidemiology; D008297:Male; D009026:Mortality
chemical_list: D015850:Interleukin-6