title: Decrease of fructosamine levels during treatment with adalimumab in patients with both diabetes and rheumatoid arthritis.
abstract: Tumour necrosis factor alpha (TNFalpha) is a pro-inflammatory cytokine which has been closely linked to obesity and insulin resistance. We present two cases of patients with rheumatoid arthritis (RA) and concomitant diabetes mellitus, who showed a marked decrease of fructosamine levels after initiating therapy with adalimumab, a TNFalpha-blocking agent, for active RA. This finding may implicate that TNFalpha blockade causes better glycaemic control in RA patients with concomitant diabetes, possibly by improving insulin resistance.
authors.affiliation: Department of Rheumatology, Jan van Breemen Institute, Amsterdam, The Netherlands.
authors.forename: I C
authors.initials: IC
authors.lastname: van Eijk
authors.forename: M J L
authors.initials: MJ
authors.lastname: Peters
authors.forename: M T
authors.initials: MT
authors.lastname: Nurmohamed
authors.forename: A W
authors.initials: AW
authors.lastname: van Deutekom
authors.forename: B A C
authors.initials: BA
authors.lastname: Dijkmans
authors.forename: S
authors.initials: S
authors.lastname: Simsek
mesh_terms: D000068879:Adalimumab; D000328:Adult; D000368:Aged; D000893:Anti-Inflammatory Agents / Q000009:adverse effects / Q000627:therapeutic use; D000911:Antibodies, Monoclonal / Q000009:adverse effects / Q000627:therapeutic use*; D061067:Antibodies, Monoclonal, Humanized; D001172:Arthritis, Rheumatoid / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D005260:Female; D019270:Fructosamine / Q000097:blood*; D006801:Humans; D008297:Male; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology
chemical_list: D000893:Anti-Inflammatory Agents; D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D014409:Tumor Necrosis Factor-alpha; D019270:Fructosamine; D000068879:Adalimumab