title: F-16438s, novel binding inhibitors of CD44 and hyaluronic acid. II. Producing organism, fermentation, isolation, physico-chemical properties and structural elucidation.
abstract: In the course of our screening for binding inhibitors of CD44 and hyaluronic acid, five active compounds, F-16438 A, B, E, F and G were found and isolated from the cultured broth of a fungal strain, Gloeoporus dichrous SANK 30502. The structures of these compounds except for F-16438 G were elucidated by physico-chemical and spectral data to be new compounds related to caloporoside; F-16438 G was identified to be the 6'-malonylated derivative of caloporoside.
authors.affiliation: Core Technology Research Laboratories, Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Hirota-Takahata
authors.forename: Hosami
authors.initials: H
authors.lastname: Harada
authors.forename: Isshin
authors.initials: I
authors.lastname: Tanaka
authors.forename: Tomoko
authors.initials: T
authors.lastname: Nakata
authors.forename: Mutsuo
authors.initials: M
authors.lastname: Nakajima
authors.forename: Masaaki
authors.initials: M
authors.lastname: Takahashi
mesh_terms: D005285:Fermentation; D018960:Hyaluronan Receptors / Q000378:metabolism*; D006820:Hyaluronic Acid / Q000037:antagonists & inhibitors* / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D008362:Mannosides / Q000737:chemistry / Q000302:isolation & purification*; D008968:Molecular Conformation; D020072:Polyporales / Q000378:metabolism*; D012459:Salicylates / Q000737:chemistry / Q000302:isolation & purification*
chemical_list: D018960:Hyaluronan Receptors; D008362:Mannosides; D012459:Salicylates; D006820:Hyaluronic Acid