title: Synthesis and biological evaluation of 7-azaindole derivatives, synthetic cytokinin analogues.
abstract: Cytokinins, N6-substituted adenine derivatives, are plant hormones playing important roles in various processes in plant development. Furthermore, cytokinins and their derivatives are able to control mammalian cell apoptosis and differentiation. The aim of our study was the synthesis of 7-azaindole derivatives as cytokinin analogues with the Hartwig-Buchwald coupling reaction in order to evaluate their biological properties on human myeloblastic leukaemia cells (HL-60 cell line). All these compounds presented a cytotoxic activity on HL-60 cells especially the 4-phenylaminopyrrolo[2,3-b]pyridine and the 4-phenethylaminopyrrolo[2,3-b]pyridine.
authors.affiliation: SPOT-EA3857, UFR des Sciences Pharmaceutiques, 31 Avenue Monge, 37200 Tours, France.
authors.forename: Jérome
authors.initials: J
authors.lastname: Guillard
authors.forename: Maÿlis
authors.initials: M
authors.lastname: Decrop
authors.forename: Nathalie
authors.initials: N
authors.lastname: Gallay
authors.forename: Claire
authors.initials: C
authors.lastname: Espanel
authors.forename: Elodie
authors.initials: E
authors.lastname: Boissier
authors.forename: Olivier
authors.initials: O
authors.lastname: Herault
authors.forename: Marie-Claude
authors.initials: MC
authors.lastname: Viaud-Massuard
mesh_terms: D001593:Benzyl Compounds / Q000737:chemistry; D002384:Catalysis; D002453:Cell Cycle; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D003583:Cytokinins / Q000737:chemistry* / Q000494:pharmacology*; D015195:Drug Design; D004354:Drug Screening Assays, Antitumor; D018922:HL-60 Cells; D006801:Humans; D007211:Indoles / Q000737:chemistry* / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D008956:Models, Chemical; D008968:Molecular Conformation; D011419:Propidium / Q000494:pharmacology; D011687:Purines / Q000737:chemistry
chemical_list: C023422:7-azaindole dimer; D001593:Benzyl Compounds; D003583:Cytokinins; D007211:Indoles; D011687:Purines; D011419:Propidium; C480551:benzylaminopurine