title: Anti-plasmodial activity of some constituents of the root bark of Harungana madagascariensis LAM. (Hypericaceae).
abstract: Bazouanthrone (1), a new anthrone derivative, has been isolated from the root bark of Harungana madagascariensis, together with known compounds, feruginin A (2), harunganin (3), harunganol A (4), harunganol B (5), friedelan-3-one (6) and betulinic acid (7). The structure of the compound (1) was assigned as 3,5,8,9-tetrahydroxy-2,4,4-tri-(3,3-dimethylallyl)-6-methyl-1-(4H)-anthracenone, by means of spectroscopic analysis. The anti-plasmodial activity of the isolated compounds was evaluated in culture against W2 strain of Plasmodium falciparum. All the compounds were found to be active against the Plasmodium parasites with bazouanthrone (1) showing particular potency (IC50=1.80 microM).
authors.affiliation: Department of Chemistry, Higher Teachers' Training College, University of Yaoundé 1, Yaoundé, Cameroon.
authors.forename: Bruno
authors.initials: B
authors.lastname: Ndjakou Lenta
authors.forename: Silvère
authors.initials: S
authors.lastname: Ngouela
authors.forename: Fabrice
authors.initials: F
authors.lastname: Fekam Boyom
authors.forename: Ferdinand
authors.initials: F
authors.lastname: Tantangmo
authors.forename: Guy Raymond
authors.initials: GR
authors.lastname: Feuya Tchouya
authors.forename: Etienne
authors.initials: E
authors.lastname: Tsamo
authors.forename: Jiri
authors.initials: J
authors.lastname: Gut
authors.forename: Philip Jon
authors.initials: PJ
authors.lastname: Rosenthal
authors.forename: Joseph
authors.initials: J
authors.lastname: Donald Connolly
mesh_terms: D000818:Animals; D000880:Anthraquinones / Q000737:chemistry / Q000494:pharmacology*; D000962:Antimalarials / Q000737:chemistry / Q000494:pharmacology*; D028084:Clusiaceae / Q000737:chemistry*; D015394:Molecular Structure; D024301:Plant Bark / Q000737:chemistry*; D018517:Plant Roots / Q000737:chemistry*; D010963:Plasmodium falciparum / Q000187:drug effects*
chemical_list: D000880:Anthraquinones; D000962:Antimalarials