Resin glycosides from the roots of Ipomoea tyrianthina and their biological activity.
Seven new tetrasaccharide glycosides, tyrianthins 1-7 (1-7), along with six known glycolipids were isolated from the roots of Ipomoea tyrianthina, and their structures were elucidated by spectroscopic and chemical methods. The content of resin glycosides in samples collected in three different regions was analyzed and compared, and the results showed that the flowering or dry season did not have any effect on the chemical composition for the same locality, but the growing location itself did affect the chemical composition of resin glycosides. Intraperitoneal administration to mice of tyrianthin 6 (6) resulted in antidepressant activity. Tyrianthin 6 (6), scammonin 1 (8), and scammonin 2 (9) exhibited dose-dependent protective effects against pentylenetetrazole-induced seizures. Also, tyrianthin 6 (6) and scammonin 2 (9) produced relaxant effects on spontaneous contractions in the isolated rat ileum.
Mirón-López
Gumersindo
G
Centro de Investigaciones Químicas, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001, Col. Chamilpa 62209 Cuernavaca, Morelos, México.
Herrera-Ruiz
Maribel
M
Estrada-Soto
Samuel
S
Aguirre-Crespo
Francisco
F
Vazquez-Navarrete
Lorena
L
León-Rivera
Ismael
I
D000818:Animals; D000928:Antidepressive Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006017:Glycolipids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D007082:Ileum / Q000187:drug effects; D027741:Ipomoea / Q000737:chemistry*; D015394:Molecular Structure; D010433:Pentylenetetrazole / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D012640:Seizures / Q000139:chemically induced
D000928:Antidepressive Agents; D006017:Glycolipids; D006027:Glycosides; D010433:Pentylenetetrazole