title: An update on the management of Wilms' tumour.
abstract: OBJECTIVE
  To review the management of Wilms' tumour.
  
  
  METHODS
  A search of the literature was performed using the PubMed database (1966 to May 2006) with the search terms 'Wilms' and either 'tumour/tumor' or 'cancer' or 'carcinoma'. This was augmented by manual searches of publications.
  
  
  RESULTS
  The success of clinical trials in Wilms' tumour patients over the past 30 years has led to an overall survival of 85% and the introduction of less aggressive chemotherapeutic regimes for patients. Large randomised controlled trials have been published on the management of Wilms' tumour by various collaborative groups, including the National Wilms' Tumour Study Group (NWTSG) in North America and the Société Internationale d'Oncologie Pédiatrique (SIOP) plus the United Kingdom Children's Cancer Study Group (UKCCSG) in Europe.
  
  
  CONCLUSIONS
  Controversy exists as to the best approach to the management of these children with regard to neoadjuvant chemotherapy. Challenges remain in the identification of histological and molecular risk factors for the stratification of treatment intensity.
authors.affiliation: Great Ormond Street Hospital for Sick Children, Great Ormond Street, London, United Kingdom.
authors.forename: H U
authors.initials: HU
authors.lastname: Ahmed
authors.forename: M
authors.initials: M
authors.lastname: Arya
authors.forename: A
authors.initials: A
authors.lastname: Tsiouris
authors.forename: S V
authors.initials: SV
authors.lastname: Sellaturay
authors.forename: I S
authors.initials: IS
authors.lastname: Shergill
authors.forename: P G
authors.initials: PG
authors.lastname: Duffy
authors.forename: I
authors.initials: I
authors.lastname: Mushtaq
mesh_terms: D003131:Combined Modality Therapy / Q000639:trends; D006801:Humans; D007680:Kidney Neoplasms / Q000628:therapy*; D016896:Treatment Outcome; D009396:Wilms Tumor / Q000628:therapy*