Formation of nano-hydroxyapatite in gelatin droplets and the resulting porous composite microspheres.
A one-pot strategy was first presented in this paper to synthesize gelatin/hydroxyapatite (HAP) composite microspheres in a water-in-oil (W/O) emulsion. Using gelatin droplets as microreactors and colloid protective medium, needle-like nano-HAP crystals (5 nm x 60-100 nm) in form of clusters were homogeneously and orderly precipitated within gelatin matrix. The results of scanning electron microscopy (SEM) revealed that the as-prepared microspheres with an average diameter of 7.5 microm displayed a narrow particle size distribution, a high dispersity and a naturally porous structure. This microsphere material is expected to have a great potential for both controlled drug release and faster bone in-growth in bone tissue engineering.
Teng
Shuhua
S
Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100080, China.
Chen
Lijuan
L
Guo
Yanchuan
Y
Shi
Jingjing
J
D017886:Durapatite / Q000737:chemistry*; D004655:Emulsions / Q000737:chemistry; D005780:Gelatin / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D008863:Microspheres; D008956:Models, Chemical; D053758:Nanoparticles / Q000737:chemistry*; D016062:Porosity
D004655:Emulsions; D005780:Gelatin; D017886:Durapatite