title: Possible protection by inhaled budesonide against ischaemic cardiac events in mild COPD.
abstract: Epidemiological studies have indicated that chronic obstructive pulmonary disease (COPD) may be associated with an increased incidence of ischaemic cardiac events. The current authors performed a post hoc analysis of the European Respiratory Society's study on Chronic Obstructive Pulmonary Disease (EUROSCOP); a 3-yr, placebo-controlled study of an inhaled corticosteroid budesonide 800 microg.day(-1) in smokers (mean age 52 yrs) with mild COPD. The current study evaluates whether long-term budesonide treatment attenuates the incidence of ischaemic cardiac events, including angina pectoris, myocardial infarction, coronary artery disorder and myocardial ischaemia. Among the 1,175 patients evaluated for safety, 49 (4.2%) patients experienced 60 ischaemic cardiac events. Patients treated with budesonide had a significantly lower incidence of ischaemic cardiac events (18 out of 593; 3.0%) than those receiving placebo (31 out of 582; 5.3%). The results of the present study support the hypothesis that treatment with inhaled budesonide reduces ischaemic cardiac events in patients with mild chronic obstructive pulmonary disease.
authors.affiliation: Department of Respiratory Medicine and Allergology, University Hospital, SE-22185 Lund, Sweden. claes-goran.lofdahl@med.lu.se
authors.forename: C-G
authors.initials: CG
authors.lastname: Löfdahl
authors.forename: D S
authors.initials: DS
authors.lastname: Postma
authors.forename: N B
authors.initials: NB
authors.lastname: Pride
authors.forename: J
authors.initials: J
authors.lastname: Boe
authors.forename: A
authors.initials: A
authors.lastname: Thorén
mesh_terms: D000280:Administration, Inhalation; D000305:Adrenal Cortex Hormones / Q000494:pharmacology; D001993:Bronchodilator Agents / Q000494:pharmacology; D019819:Budesonide / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D001239:Inhalation; D007511:Ischemia / Q000188:drug therapy* / Q000473:pathology / Q000517:prevention & control*; D008297:Male; D010919:Placebos; D011379:Prognosis; D029424:Pulmonary Disease, Chronic Obstructive / Q000188:drug therapy* / Q000453:epidemiology*; D016032:Randomized Controlled Trials as Topic; D012907:Smoking
chemical_list: D000305:Adrenal Cortex Hormones; D001993:Bronchodilator Agents; D010919:Placebos; D019819:Budesonide