title: The role of DTNBP1, NRG1, and AKT1 in the genetics of schizophrenia in Finland.
abstract: Several putative schizophrenia susceptibility genes have recently been identified. Significant associations between schizophrenia and neuregulin 1 (NRG1) and dysbindin (DTNBP1) were first reported in 2002 and studies in several populations have since independently reported positive associations to these gene regions. Further, both tentative functional and genetic data have implicated the role of AKT1 in the genetic background of this disorder. However, findings have not been consistent in all populations. We investigated the allelic diversity of these three genes NRG1, DTNBP1 and AKT1 in a representative nation-wide study sample of 441 Finnish schizophrenia families consisting of 865 affected individuals, in order to assess their role in one of the largest population-based study samples. DTNBP1 and AKT1 failed to show evidence of association, whereas two SNPs in the 3' region of the NRG1 gene yielded suggestive evidence of association (p=0.012 and p=0.048) in family-based association analyses. Thus, our study does not indicate that AKT1 or DTNBP1 play a role in the etiology of schizophrenia in the Finnish population. Furthermore, results do not support a major role for NRG1, but we cannot completely exclude a minor role of this gene in the Finnish population.
authors.affiliation: Department of Molecular Medicine, National Public Health Institute, Biomedicum, P.O. Box 104, FI-00251, Helsinki, Finland.
authors.forename: Joni A
authors.initials: JA
authors.lastname: Turunen
authors.forename: Juho O
authors.initials: JO
authors.lastname: Peltonen
authors.forename: Olli P H
authors.initials: OP
authors.lastname: Pietiläinen
authors.forename: William
authors.initials: W
authors.lastname: Hennah
authors.forename: Anu
authors.initials: A
authors.lastname: Loukola
authors.forename: Tiina
authors.initials: T
authors.lastname: Paunio
authors.forename: Kaisa
authors.initials: K
authors.lastname: Silander
authors.forename: Jesper
authors.initials: J
authors.lastname: Ekelund
authors.forename: Teppo
authors.initials: T
authors.lastname: Varilo
authors.forename: Timo
authors.initials: T
authors.lastname: Partonen
authors.forename: Jouko
authors.initials: J
authors.lastname: Lönnqvist
authors.forename: Leena
authors.initials: L
authors.lastname: Peltonen
mesh_terms: D000483:Alleles; D002352:Carrier Proteins / Q000235:genetics / Q000502:physiology*; D002883:Chromosomes, Human, Pair 14 / Q000235:genetics; D002896:Chromosomes, Human, Pair 6 / Q000235:genetics; D000074765:Dysbindin; D049029:Dystrophin-Associated Proteins; D005091:Exons / Q000235:genetics; D005387:Finland / Q000453:epidemiology; D005819:Genetic Markers; D023281:Genomics / Q000379:methods; D005838:Genotype; D006801:Humans; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000502:physiology*; D020890:Neuregulin-1; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D051057:Proto-Oncogene Proteins c-akt / Q000235:genetics / Q000502:physiology*; D012559:Schizophrenia / Q000453:epidemiology / Q000235:genetics* / Q000503:physiopathology*
chemical_list: D002352:Carrier Proteins; C432416:DTNBP1 protein, human; D000074765:Dysbindin; D049029:Dystrophin-Associated Proteins; D005819:Genetic Markers; C094131:NRG1 protein, human; D009419:Nerve Tissue Proteins; D020890:Neuregulin-1; C494918:AKT1 protein, human; D051057:Proto-Oncogene Proteins c-akt