Isolation of Lagos bat virus from water mongoose.
A genotype 2 lyssavirus, Lagos bat virus (LBV), was isolated from a terrestrial wildlife species (water mongoose) in August 2004 in the Durban area of the KwaZulu-Natal Province of South Africa. The virus isolate was confirmed as LBV by antigenic and genetic characterization, and the mongoose was identified as Atilax paludinosus by mitochondrial cytochrome b sequence analysis. Phylogenetic analysis demonstrated sequence homology with previous LBV isolates from South African bats. Studies performed in mice indicated that the peripheral pathogenicity of LBV had been underestimated in previous studies. Surveillance strategies for LBV in Africa must be improved to better understand the epidemiology of this virus and to make informed decisions on future vaccine strategies because evidence is insufficent that current rabies vaccines provide protection against LBV.
Markotter
Wanda
W
University of Pretoria, Pretoria, South Africa.
Kuzmin
Ivan
I
Rupprecht
Charles E
CE
Randles
Jenny
J
Sabeta
Claude T
CT
Wandeler
Alexander I
AI
Nel
Louis H
LH
D000818:Animals; D000956:Antigens, Viral / Q000302:isolation & purification; D001681:Biological Assay / Q000662:veterinary; D045303:Cytochromes b / Q000737:chemistry / Q000235:genetics; D004272:DNA, Mitochondrial / Q000737:chemistry / Q000235:genetics; D019084:Fluorescent Antibody Technique, Indirect / Q000662:veterinary; D008988:Herpestidae / Q000235:genetics / Q000821:virology*; D018114:Lyssavirus / Q000235:genetics / Q000302:isolation & purification* / Q000472:pathogenicity; D051379:Mice; D008813:Mice, Inbred ICR; D019590:Nucleocapsid Proteins / Q000235:genetics / Q000302:isolation & purification; D010802:Phylogeny; D012367:RNA, Viral / Q000737:chemistry / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction / Q000662:veterinary; D018353:Rhabdoviridae Infections / Q000662:veterinary* / Q000821:virology; D017422:Sequence Analysis, DNA; D013019:South Africa; D014774:Virulence
D000956:Antigens, Viral; D004272:DNA, Mitochondrial; D019590:Nucleocapsid Proteins; D012367:RNA, Viral; D045303:Cytochromes b