Cytotoxic 6-alkylsalicylic acids from the endophytic Streptomyces laceyi.
Two new 6-alkylsalicylic acids, salaceyins A and B were isolated by bioassay-guided fractionation from the culture of the endophytic Streptomyces laceyi MS53 and their structures were determined on the basis of spectroscopic data. Salaceyins A and B exhibited modest cytotoxicity against a human breast cancer cell line (SKBR3) with IC50 values of 3.0 and 5.5 microg/ml, respectively.
Kim
Nahyun
N
Division of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 136-713, Korea.
Shin
Jin Chul
JC
Kim
Woncheol
W
Hwang
Bang Yeon
BY
Kim
Beom Seok
BS
Hong
Young-Soo
YS
Lee
Dongho
D
D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D045744:Cell Line, Tumor; D006801:Humans; D012459:Salicylates / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013302:Streptomyces / Q000378:metabolism*
D000970:Antineoplastic Agents; D012459:Salicylates; C518209:salaceyin A; C518210:salaceyin B