title: A new and efficient strategy for the synthesis of podophyllotoxin and its analogues.
abstract: [structure: see text]. An efficient and stereoselective strategy for the total synthesis of podophyllotoxin was developed. This route leads to podophyllotoxin 1 in only 12 steps with 29% overall yield. A notable feature of this synthetic strategy is the use of the cascade addition-alkylation to ensure the key C1-C2 stereochemistry that is pivotal for the synthesis of podophyllotoxin.
authors.affiliation: Key Laboratory of Medicinal Chemistry for Natural Resource (Yunnan University), Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming, Yunnan, PR China.
authors.forename: Yingming
authors.initials: Y
authors.lastname: Wu
authors.forename: Hongbin
authors.initials: H
authors.lastname: Zhang
authors.forename: Yuanhong
authors.initials: Y
authors.lastname: Zhao
authors.forename: Jingfeng
authors.initials: J
authors.lastname: Zhao
authors.forename: Jingbo
authors.initials: J
authors.lastname: Chen
authors.forename: Liang
authors.initials: L
authors.lastname: Li
mesh_terms: D000478:Alkylation; D015394:Molecular Structure; D011034:Podophyllotoxin / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D011034:Podophyllotoxin