title: Nipple-sparing mastectomy. Preliminary results.
abstract: Nipple-sparing mastectomy (NSM) combines a skin-sparing mastectomy with preservation of the Nipple Areola Complex (NAC), intraoperative pathological assessment of the nipple tissue core, and immediate reconstruction, thereby permitting better cosmesis for patients undergoing total mastectomy. Radiotherapy of the NAC was carried out in every single patient after surgery. The procedure was first performed on selected patients following a clinical research protocol. From January 2003 to June 2004, 10 patients underwent nipple sparing mastectomy followed by reconstruction (4 of them decided also to undergo a prophylactic mastectomy on the other breast) at the Breast Unit, Policlinico Monteluce, Perugia, Italy. Patients had been accurately selected before the operation following some criteria previously assessed by a team of specialists including the breast surgeon, the oncological physician, the radiotherapist and the plastic surgeon. Histology of the 10 NSMs confirmed invasive carcinoma in 3 cases and in situ carcinoma in the remainder. Superficial necrosis of the NAC that settled down spontaneously without consequences occurred in 2 cases; loss of sensitivity of the NAC in 4 patients; 1 patient developed haematoma. No asymmetry was reported. All women were clear of cancer after the treatment. Nipple-sparing mastectomy is the procedure of choice on selected patients.
authors.affiliation: Plastic Surgery Unit, Department of Surgical, Radiological and Odontostomatological Sciences, University of Perugia, Policlinico Monteluce, Perugia, Italy. giastar@alice.it
authors.forename: G
authors.initials: G
authors.lastname: Bistoni
authors.forename: A
authors.initials: A
authors.lastname: Rulli
authors.forename: L
authors.initials: L
authors.lastname: Izzo
authors.forename: G
authors.initials: G
authors.lastname: Noya
authors.forename: C
authors.initials: C
authors.lastname: Alfano
authors.forename: F
authors.initials: F
authors.lastname: Barberini
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D015412:Mastectomy, Segmental / Q000379:methods*; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D009558:Nipples / Q000473:pathology*; D021701:Sentinel Lymph Node Biopsy