title: Nanobacteria-associated calcific aortic valve stenosis.
abstract: Calcific aortic valve stenosis is the most common valvular disease in developed countries, and the major reason for operative valve replacement. In the US, the current annual cost of this surgery is approximately 1 billion dollars. Despite increasing morbidity and mortality, little is known of the cellular basis of the calcifications, which occur in high-perfusion zones of the heart. The case is presented of a patient with calcific aortic valve stenosis and colonies of progressively mineralized nanobacteria in the fibrocalcific nodules of the aortic cusps, as revealed by transmission electron microscopy. Consistent with their outstanding bioadhesivity, nanobacteria might serve as causative agents in the development of calcific aortic valve stenosis.
authors.affiliation: Department of Pathology, Charleston Area Medical Center, West Virginia University, WV 25304, USA. tomislav.jelic@camc.org
authors.forename: Tomislav M
authors.initials: TM
authors.lastname: Jelic
authors.forename: Ho-Huang
authors.initials: HH
authors.lastname: Chang
authors.forename: Rod
authors.initials: R
authors.lastname: Roque
authors.forename: Amer M
authors.initials: AM
authors.lastname: Malas
authors.forename: Stafford G
authors.initials: SG
authors.lastname: Warren
authors.forename: Andrei P
authors.initials: AP
authors.lastname: Sommer
mesh_terms: D000369:Aged, 80 and over; D001024:Aortic Valve Stenosis / Q000382:microbiology* / Q000473:pathology; D001031:Apatites; D001424:Bacterial Infections / Q000150:complications / Q000473:pathology*; D002114:Calcinosis / Q000382:microbiology* / Q000473:pathology; D002130:Calcium Phosphates; D005260:Female; D006801:Humans; D046529:Microscopy, Electron, Transmission; D053758:Nanoparticles / Q000382:microbiology* / Q000648:ultrastructure
chemical_list: D001031:Apatites; D002130:Calcium Phosphates; C020243:calcium phosphate