title: [Trace elements in human nutrition: biological indices of zinc insufficiency].
abstract: The review, discusses current data on biological indices that respond specifically to changes in Zn safety. The most reliable is the method of Zn safety evaluation based on its stores in organism measurement by means of stable isotopes. Zn status estimation by its levels determination in different kinds of available biological material (plasma, serum and whole blood, saliva, sweat, urine, hair, tissue samples) has different limitations. Some advances have so named physiological Zn safety criteria however their use is poorly validated or complicated with estimations subjectivity. Currently the first place belongs to a group of methods based on measurement of Zn-dependent proteins levels or activities together with their genes expression especially for such Zn-dependent enzyme as alkaline phosphatase.
authors.forename: I V
authors.initials: IV
authors.lastname: Gmoshinskiĭ
authors.forename: B
authors.initials: B
authors.lastname: Munkhuu
authors.forename: V K
authors.initials: VK
authors.lastname: Mazo
mesh_terms: D000469:Alkaline Phosphatase / Q000378:metabolism*; D000818:Animals; D015415:Biomarkers / Q000032:analysis / Q000378:metabolism; D004032:Diet; D006801:Humans; D014131:Trace Elements / Q000378:metabolism*; D015032:Zinc / Q000032:analysis / Q000172:deficiency* / Q000378:metabolism*; D015033:Zinc Isotopes / Q000032:analysis / Q000378:metabolism / Q000494:pharmacology
chemical_list: D015415:Biomarkers; D014131:Trace Elements; D015033:Zinc Isotopes; D000469:Alkaline Phosphatase; D015032:Zinc