title: [Multiple gastrointestinal stromal tumors in neurofibromatosis type 1].
abstract: BACKGROUND
  Gastrointestinal stromal tumors (GIST) are generally rare, but appear more frequently in patients with neurofibromatosis type 1. Mostly asymptomatic, GIST can also cause relevant clinical appearances such as gastrointestinal bleeding, obstruction, or invagination. In recent years, a significant expert knowledge was gained in biology and treatment of these tumors.
  
  
  METHODS
  The case of a 50-year-old man with a history of neurofibromatosis type 1 and acute gastrointestinal bleeding is described. In the index upper endoscopy an ulcerated tumor of the proximal small bowel was found. The histopathologic examination showed a GIST. Segmental small bowel resection was carried out. Over the course of 1 year, there has been no evidence of a recurrence, metastases, or metachronous GIST.
  
  
  CONCLUSIONS
  Considering the distinct biology of GIST in patients with neurofibromatosis type 1, the recommendation for a generous endoscopic examination or a routine endoscopy in this population is discussed.
authors.affiliation: 2. Klinik für Innere Medizin, Städtisches Klinikum St. Georg, Leipzig, Germany. markus.zachaeus@parkkrankenhaus-leipzig.de
authors.forename: Markus
authors.initials: M
authors.lastname: Zachäus
authors.forename: Andreas
authors.initials: A
authors.lastname: Plötner
authors.forename: Arved
authors.initials: A
authors.lastname: Weimann
authors.forename: Bernhard
authors.initials: B
authors.lastname: Ruf
mesh_terms: D001706:Biopsy; D004724:Endoscopy; D005500:Follow-Up Studies; D046152:Gastrointestinal Stromal Tumors / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology / Q000601:surgery; D006801:Humans; D007150:Immunohistochemistry; D007580:Jejunal Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology / Q000601:surgery; D007583:Jejunum / Q000473:pathology; D008297:Male; D008551:Melena / Q000209:etiology; D008875:Middle Aged; D009154:Mutation; D009378:Neoplasms, Multiple Primary / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology / Q000601:surgery; D009456:Neurofibromatosis 1 / Q000150:complications*; D019009:Proto-Oncogene Proteins c-kit / Q000235:genetics; D012307:Risk Factors; D013997:Time Factors
chemical_list: D019009:Proto-Oncogene Proteins c-kit