Synthetic N-pyridinyl(methyl)-indol-3-ylpropanamides as new potential immunosuppressive agents.
Several N-pyridinyl(methyl)-indol-3-ylpropanamides were synthesized and pharmacological evaluations of their immunosuppressive potential were performed. Among thirteen compounds tested in vitro on murine T proliferation, three showed interesting inhibiting activity. For the most active compound (propanamide 18), immunosuppressive activity was documented both in vitro on human T lymphocytes proliferation and in vivo on mice delayed-type hypersensitivity. These experimental data demonstrated that these compounds hold potential as immunosuppressive agents.
Carbonnelle
Delphine
D
Nantes University, Nantes Atlantique Universities, Immuno-Pharmacology Department, BioCiT, UPRES EA 1155, Faculty of Pharmacy, 1 rue Gaston Veil, Nantes, France.
Lardic
Morgane
M
Dassonville
Alexandra
A
Verron
Elise
E
Petit
Jean-Yves
JY
Duflos
Muriel
M
Lang
François
F
D000577:Amides / Q000737:chemistry; D000818:Animals; D049109:Cell Proliferation; D005260:Female; D006801:Humans; D006968:Hypersensitivity, Delayed; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D007211:Indoles / Q000737:chemistry / Q000494:pharmacology*; D051379:Mice; D008807:Mice, Inbred BALB C; D011725:Pyridines / Q000737:chemistry / Q000494:pharmacology*; D013601:T-Lymphocytes / Q000187:drug effects
D000577:Amides; D007166:Immunosuppressive Agents; D007211:Indoles; D011725:Pyridines