title: Atypical cytology in a persistent seroma following mastectomy for breast cancer: a case report and review of the literature.
abstract: Improvement in local control with radiation therapy translates to a survival benefit in patients with breast cancer. The magnitude this benefit is proportional to the magnitude of the improvement in local control. Since the proportional reduction of local recurrence with the addition of radiation is relatively constant, it is important to determine the probability of local recurrence in order to guide therapy. There are a number of factors, including lymph node involvement, lymphovascular invasion, and size of the primary tumor that correlate with risk of local recurrence. There is very little data on the prognostic significance of malignant cells in seroma fluid after mastectomy or axillary dissection. We report a case of a woman with atypical cells in a persistent seroma following mastectomy for node negative infiltrating ductal carcinoma.
authors.affiliation: Harvard Radiation Oncology Program, Boston, Massachusetts 02115, USA. bmalexander@partners.org
authors.forename: Brian M
authors.initials: BM
authors.lastname: Alexander
authors.forename: Brad
authors.initials: B
authors.lastname: Bryan
authors.forename: Laura C
authors.initials: LC
authors.lastname: Collins
authors.forename: Abram
authors.initials: A
authors.lastname: Recht
mesh_terms: D001943:Breast Neoplasms / Q000473:pathology / Q000601:surgery*; D018270:Carcinoma, Ductal, Breast / Q000473:pathology / Q000601:surgery*; D004847:Epithelial Cells / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D015413:Mastectomy, Simple; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D021701:Sentinel Lymph Node Biopsy; D049291:Seroma / Q000473:pathology*