title: [Nosocomial outbreak of epidemic keratoconjunctivitis in a neonatal intensive care unit].
abstract: OBJECTIVE
  To describe an epidemic nosocomial outbreak of keratoconjunctivitis affecting at least 43 people in a Neonatal Intensive Care Unit in Madrid, between May and October 2002, perform epidemiologic research and determine preventive measures to prevent new outbreaks.
  
  
  METHODS
  Description of the outbreak, clinical case definition, microbiologic and epidemiologic research through the use of questionnaires. Analysis of the incidence of subepithelial infiltrates 1 year after infection and the use of topical corticosteroid therapy.
  
  
  RESULTS
  The epidemic began in the Neonatal Service, with a pair of twins being found as the initial focus. Dissemination occurred to about 24 workers of the unit, and 19 workers from other services. The microbiologic diagnosis confirmed adenovirus in 10 conjunctival smears and one serologically, with the remainder obeying clinical and epidemiological criteria of such infection. Infected patients using topical corticosteroids had a higher incidence of infiltrates 12 months later than those not using such agents (p=0.003 in Fisher test).
  
  
  CONCLUSIONS
  Epidemic keratoconjunctivitis occurs frequently, is highly contagious and has possible long-term sequelae, necessitating the use of preventive measures to avoid spread and new outbreaks.
authors.affiliation: Servicio de Oftalmología, Hospital General Universitario La Paz, Madrid, España. masedur@terra.es
authors.forename: M
authors.initials: M
authors.lastname: Asencio-Durán
authors.forename: R
authors.initials: R
authors.lastname: Romero-Martín
authors.forename: J R
authors.initials: JR
authors.lastname: García-Martínez
authors.forename: J M
authors.initials: JM
authors.lastname: Peralta-Calvo
authors.forename: V
authors.initials: V
authors.lastname: Pérez-Blanco
authors.forename: J
authors.initials: J
authors.lastname: García-Caballero
authors.forename: C
authors.initials: C
authors.lastname: Malo-Martínez
mesh_terms: D000328:Adult; D003231:Conjunctivitis / Q000150:complications / Q000453:epidemiology*; D003428:Cross Infection / Q000453:epidemiology*; D004196:Disease Outbreaks; D005260:Female; D006801:Humans; D007363:Intensive Care Units, Neonatal; D007634:Keratitis / Q000150:complications / Q000453:epidemiology*; D008297:Male