Auditory event-related potentials in Parkinson's disease: prominent correlation with attention.
OBJECTIVE
Auditory P300 has been reported to be abnormal in demented patients with Parkinson's disease. However, it is still controversial which factors in Parkinson's disease influence P300 parameters.


METHODS
Forty patients with Parkinson's disease were included. Patients were divided into two groups: patients with dementia (PDD) and without dementia (PDND). An 'odd-ball' paradigm was used for auditory event-related potentials.


RESULTS
P300 latency was markedly delayed in PDD patients. Age and DRS1 (attention) were the most important factors influencing P300 latency.


CONCLUSIONS
Although there have been reports of P300 in the past, its abnormalities reflect the deficit of attention in Parkinson's disease.
Matsui
Hideaki
H
Department of Neurology, Sumitomo Hospital, 5-3-20 Nakanoshima, Osaka, Japan. hide0729@kuhp.kyoto-u.ac.jp
Nishinaka
Kazuto
K
Oda
Masaya
M
Kubori
Tamotsu
T
Udaka
Fukashi
F
D000161:Acoustic Stimulation / Q000379:methods; D000368:Aged; D000369:Aged, 80 and over; D003704:Dementia / Q000503:physiopathology; D004569:Electroencephalography; D018913:Event-Related Potentials, P300 / Q000502:physiology*; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D010300:Parkinson Disease / Q000503:physiopathology*