Osmotic myelinolysis syndrome after treatment of severe deamino arginine vasopressin-associated hyponatraemia: pitfalls in emergency medicine.
Hyponatraemia is among the more common electrolyte abnormalities encountered in the ED. Both the primary disturbance and its correction can result in life-threatening neurological sequelae. Osmotic myelinolysis syndrome is one such complication and is associated with the rapid correction of hyponatraemia. The present case report describes the mechanism of severe hyponatraemia in a patient taking deamino arginine vasopressin, and the subsequent development of both central pontine and extrapontine myelinolysis after rapid correction of sodium levels. Implications for the emergency management of such patients are discussed.
Gutenstein
Marc
M
Anaesthetic Department, North Devon District Hospital, Barnstaple, UK. Doctormarco@yahoo.co.uk
D000328:Adult; D003894:Deamino Arginine Vasopressin / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007010:Hyponatremia / Q000150:complications* / Q000628:therapy*; D017590:Myelinolysis, Central Pontine / Q000209:etiology / Q000378:metabolism*; D009995:Osmosis; D012964:Sodium / Q000378:metabolism; D013577:Syndrome
D012964:Sodium; D003894:Deamino Arginine Vasopressin