Neuritogenic activity of gangliosides from echinoderms and their structure-activity relationship.
The effects of the gangliosides isolated from echinoderms on the neuritogenesis of a rat pheochromocytoma cell line (PC-12 cells) in the presence of nerve growth factor were investigated. The results show that they displayed neuritogenic activity. Based on the observed results, a structure-activity relationship has been established.
Kaneko
Masafumi
M
Faculty of Pharmaceutical Sciences, Kyushu University, Maidashi, Fukuoka, Japan.
Yamada
Koji
K
Miyamoto
Tomofumi
T
Inagaki
Masanori
M
Higuchi
Ryuichi
R
D000818:Animals; D004447:Echinodermata / Q000737:chemistry*; D005732:Gangliosides / Q000737:chemistry* / Q000494:pharmacology*; D015394:Molecular Structure; D020932:Nerve Growth Factor / Q000494:pharmacology; D016716:PC12 Cells; D010673:Pheochromocytoma / Q000188:drug therapy; D051381:Rats; D013329:Structure-Activity Relationship
D005732:Gangliosides; D020932:Nerve Growth Factor