Further evidence for adipocytic differentiation by the neoplastic myoepithelium.
Lipomatous pleomorphic adenoma (PA)/myoepithelioma is rare. Nevertheless, adipocytic differentiation in salivary gland tumors is a well-known phenomenon. As extensive lipometaplasia occurs primarily in adenomas with myoepithelial participation, circumstantial evidence implicates neoplastic myoepithelium (NME), especially the spindle type, as a key partaker. We report here a unique PA that represents an equivocal transition from the epithelioid NME to adipocytes in recurrent lesions but not in a primary tumor.
Ide
F
F
Division of Pathology, Department of Diagnostic and Therapeutic Sciences, Meikai University School of Dentistry, Saitama, Japan. idef@dent.meikai.ac.jp <idef@dent.meikai.ac.jp>
Tanaka
A
A
Kusama
K
K
D008949:Adenoma, Pleomorphic / Q000473:pathology*; D017667:Adipocytes / Q000473:pathology*; D000328:Adult; D002454:Cell Differentiation; D004847:Epithelial Cells / Q000473:pathology*; D006801:Humans; D008297:Male; D009208:Myoepithelioma / Q000473:pathology*; D009364:Neoplasm Recurrence, Local; D012468:Salivary Gland Neoplasms / Q000473:pathology*