title: ABCA1 polymorphisms and Alzheimer's disease.
abstract: In our search for genetic factors related to the development of Alzheimer's disease, we have genotyped 332 pedigrees for three coding polymorphisms in the ABCA1 gene, two of which are known to alter plasma cholesterol levels, as well as a non-coding polymorphism within the promoter. We show an apparent weak association of rs2230806 (p-value=0.01) with the disease in a sibpair series of Alzheimer's disease that had shown previously evidence for linkage to the chromosome 9 locus where ABCA1 maps.
authors.affiliation: Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, 35 Convent Drive, Room 1A1015 MSC 3707, Bethesda, MD 20892-3707, USA. wavrant@mail.nih.gov
authors.forename: Fabienne
authors.initials: F
authors.lastname: Wavrant-De Vrièze
authors.forename: Danielle
authors.initials: D
authors.lastname: Compton
authors.forename: Meridith
authors.initials: M
authors.lastname: Womick
authors.forename: Sampath
authors.initials: S
authors.lastname: Arepalli
authors.forename: Omanma
authors.initials: O
authors.lastname: Adighibe
authors.forename: Ling
authors.initials: L
authors.lastname: Li
authors.forename: Jordi
authors.initials: J
authors.lastname: Pérez-Tur
authors.forename: John
authors.initials: J
authors.lastname: Hardy
mesh_terms: D064286:ATP Binding Cassette Transporter 1; D018528:ATP-Binding Cassette Transporters / Q000235:genetics*; D000368:Aged; D000544:Alzheimer Disease / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D010375:Pedigree; D012150:Polymorphism, Restriction Fragment Length; D012307:Risk Factors
chemical_list: C577836:ABCA1 protein, human; D064286:ATP Binding Cassette Transporter 1; D018528:ATP-Binding Cassette Transporters