Hydrogen-bonded interpolymer complexes as materials for pharmaceutical applications.
Association of poly(carboxylic acids) and non-ionic polymers in solutions via hydrogen bonding results in formation of novel polymeric materials--interpolymer complexes. These materials can potentially be used for design of novel mucoadhesive dosage forms, development of solid drug dispersions and solubilisation of poorly soluble drugs, encapsulation technologies, preparation of nanoparticles, hydrogels, in situ gelling systems and electrically erodible materials. This review is an attempt to analyse and systematise existing literature on pharmaceutical application of hydrogen-bonded interpolymer complexes.
Khutoryanskiy
Vitaliy V
VV
University of Reading, School of Pharmacy, Whiteknights, PO Box 224, Reading RG6 6AD, UK. v.khutoryanskiy@reading.ac.uk
D000268:Adhesiveness; D002264:Carboxylic Acids / Q000737:chemistry*; D003692:Delayed-Action Preparations / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems; D005782:Gels / Q000737:chemistry; D020100:Hydrogels / Q000737:chemistry; D006860:Hydrogen Bonding; D053758:Nanoparticles / Q000737:chemistry; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry*
D002264:Carboxylic Acids; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D005782:Gels; D020100:Hydrogels; D011108:Polymers