Mutasynthesis - uniting chemistry and genetics for drug discovery.
Mutasynthesis couples the power of chemical synthesis with molecular biology to generate derivatives of medicinally valuable, natural products. Recently, this technique has been exploited by Cambridge-based biotech company Biotica Technology Ltd, and their collaborators, to generate promising new variants of the polyketide anti-cancer compounds rapamycin and borrelidin.
Weissman
Kira J
KJ
Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, UK. kjw21@cam.ac.uk
D002621:Chemistry / Q000639:trends*; D015195:Drug Design; D005233:Fatty Alcohols / Q000737:chemistry / Q000627:therapeutic use; D005818:Genetic Engineering / Q000639:trends*; D009154:Mutation; D020123:Sirolimus / Q000737:chemistry* / Q000627:therapeutic use; D013678:Technology, Pharmaceutical / Q000639:trends*
D005233:Fatty Alcohols; C005066:borrelidin; D020123:Sirolimus