title: Computer-based insulin infusion protocol improves glycemia control over manual protocol.
abstract: OBJECTIVE
  Hyperglycemia worsens clinical outcomes in critically ill patients. Precise glycemia control using intravenous insulin improves outcomes. To determine if we could improve glycemia control over a previous paper-based, manual protocol, authors implemented, in a surgical intensive care unit (SICU), an intravenous insulin protocol integrated into a care provider order entry (CPOE) system.
  
  
  METHODS
  Retrospective before-after study of consecutive adult patients admitted to a SICU during pre (manual protocol, 32 days) and post (computer-based protocol, 49 days) periods.
  
  
  METHODS
  Percentage of glucose readings in ideal range of 70-109 mg/dl, and minutes spent in ideal range of control during the first 5 days of SICU stay.
  
  
  RESULTS
  The computer-based protocol reduced time from first glucose measurement to initiation of insulin protocol, improved the percentage of all SICU glucose readings in the ideal range, and improved control in patients on IV insulin for > or =24 hours. Hypoglycemia (<40 mg/dl) was rare in both groups.
  
  
  CONCLUSIONS
  The CPOE-based intravenous insulin protocol improved glycemia control in SICU patients compared to a previous manual protocol, and reduced time to insulin therapy initiation. Integrating a computer-based insulin protocol into a CPOE system achieved efficient, safe, and effective glycemia control in SICU patients.
authors.affiliation: Vanderbilt University, Division of Cardiovascular Medicine, Nashville, TN 37232-8802, USA. jeffrey.boord@vanderbilt.edu
authors.forename: Jeffrey B
authors.initials: JB
authors.lastname: Boord
authors.forename: Mona
authors.initials: M
authors.lastname: Sharifi
authors.forename: Robert A
authors.initials: RA
authors.lastname: Greevy
authors.forename: Marie R
authors.initials: MR
authors.lastname: Griffin
authors.forename: Vivian K
authors.initials: VK
authors.lastname: Lee
authors.forename: Ty A
authors.initials: TA
authors.lastname: Webb
authors.forename: Michael E
authors.initials: ME
authors.lastname: May
authors.forename: Lemuel R
authors.initials: LR
authors.lastname: Waitman
authors.forename: Addison K
authors.initials: AK
authors.lastname: May
authors.forename: Randolph A
authors.initials: RA
authors.lastname: Miller
mesh_terms: D001786:Blood Glucose / Q000378:metabolism; D016638:Critical Illness / Q000628:therapy; D004360:Drug Therapy, Computer-Assisted; D005260:Female; D006801:Humans; D006943:Hyperglycemia / Q000188:drug therapy*; D007004:Hypoglycemic Agents / Q000008:administration & dosage*; D007262:Infusions, Intravenous; D007328:Insulin / Q000008:administration & dosage*; D007362:Intensive Care Units; D008297:Male; D050316:Medical Order Entry Systems; D008875:Middle Aged; D012189:Retrospective Studies; D018511:Systems Integration; D014584:User-Computer Interface
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin