title: [Pulmonary injury by an over-the-counter drug, Nospole G].
abstract: A 78-year-old woman was admitted with dyspnea. She had caught a cold and took an over-the-counter drug (Nospole G) for 2 weeks before admission. Chest radiography and CT scanning showed bilateral diffuse and interstitial shadows, and arterial blood gas analysis demonstrated severe hypoxemia. Withdrawal of Nospole and treatment with both corticosteroid and sivelestat sodium resulted in improvement of clinical findings and successful recovery from mechanical ventilation. A drug lymphocyte stimulation test for Nospole G was positive. Based on these findings, we determined that this patient had drug-induced pneumonitis caused by Nospole G. Finally, she died of sepsis caused by multidrug-resistant Staphylococcus aureus (MRSA) infection. In summary, we report here an elderly case of drug-induced pneumonitis successfully weaned from mechanical ventilation by early treatment with corticosteroid and sivelestat sodium, monitored by changes of markers for interstitial pneumonitis (KL-6, SP-A, SP-D).
authors.affiliation: Department of Respiratory Medicine, Yokohama Municipal Citizen's Hospital.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Narita
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Naoki
authors.forename: Naoya
authors.initials: N
authors.lastname: Hida
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Okamoto
mesh_terms: D000368:Aged; D003139:Common Cold / Q000188:drug therapy*; D005260:Female; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000473:pathology; D004366:Nonprescription Drugs / Q000009:adverse effects*; D012120:Respiration Disorders / Q000209:etiology; D014057:Tomography, X-Ray Computed
chemical_list: D004366:Nonprescription Drugs