Bioactive saponins and glycosides. XXVII. Structures of new cucurbitane-type triterpene glycosides and antiallergic constituents from Citrullus colocynthis.
The methanolic extract from the fruit of Citrullus colocynthis showed an inhibitory effect on ear passive cutaneous anaphylaxis reactions as a type I allergic model in mice. From the methanolic extract, two new cucurbitane-type triterpene glycosides, colocynthosides A and B, were isolated together with 17 known constituents. The structures of colocynthosides A and B were elucidated on the basis of chemical and physicochemical evidence. In addition, the principal cucurbitane-type triterpene glycoside, cucurbitacin E 2-O-beta-D-glucopyranoside, and its aglycon, cucurbitacin E, exhibited the antiallergic activity at a dose of 100 and 1.25 mg/kg, p.o., respectively.
Yoshikawa
Masayuki
M
Kyoto Pharmaceutical University, Yamashina-ku, Kyoto, Japan. myoshika@mb.kyoto-phu.ac.jp
Morikawa
Toshio
T
Kobayashi
Hisanori
H
Nakamura
Akihiko
A
Matsuhira
Koudai
K
Nakamura
Seikou
S
Matsuda
Hisashi
H
D000707:Anaphylaxis / Q000188:drug therapy; D000818:Animals; D029773:Citrullus / Q000737:chemistry*; D006027:Glycosides / Q000737:chemistry* / Q000494:pharmacology*; D008297:Male; D051379:Mice; D015394:Molecular Structure; D012503:Saponins / Q000737:chemistry* / Q000494:pharmacology*; D014315:Triterpenes / Q000737:chemistry* / Q000494:pharmacology*
D006027:Glycosides; D012503:Saponins; D014315:Triterpenes; C514277:cucurbitane