title: Dosimetric study and in-vivo dose verification for conformal avoidance treatment of anal adenocarcinoma using helical tomotherapy.
abstract: This study evaluated the efficacy of using helical tomotherapy for conformal avoidance treatment of anal adenocarcinoma. We retrospectively generated step-and-shoot intensity-modulated radiotherapy (sIMRT) plans and helical tomotherapy plans for two anal cancer patients, one male and one female, who were treated by the sIMRT technique. Dose parameters for the planning target volume (PTV) and the organs-at-risk (OARs) were compared between the sIMRT and the helical tomotherapy plans. The helical tomotherapy plans showed better dose homogeneity in the PTV, better dose conformity around the PTV, and, therefore, better sparing of nearby OARs compared with the sIMRT plans. In-vivo skin dose measurements were performed during conformal avoidance helical tomotherapy treatment of an anal cancer patient to verify adequate delivery of skin dose and sparing of OARs.
authors.affiliation: Department of Radiation Physics, City of Hope National Medical Center, Duarte, CA 91010, USA. chan@coh.org
authors.forename: Chunhui
authors.initials: C
authors.lastname: Han
authors.forename: Yi-Jen
authors.initials: YJ
authors.lastname: Chen
authors.forename: An
authors.initials: A
authors.lastname: Liu
authors.forename: Timothy E
authors.initials: TE
authors.lastname: Schultheiss
authors.forename: Jeffrey Y C
authors.initials: JY
authors.lastname: Wong
mesh_terms: D000230:Adenocarcinoma / Q000532:radiotherapy*; D001005:Anus Neoplasms / Q000532:radiotherapy*; D005260:Female; D006801:Humans; D008297:Male; D011879:Radiotherapy Dosage; D050397:Radiotherapy, Intensity-Modulated / Q000379:methods*; D012867:Skin / Q000528:radiation effects; D036542:Tomography, Spiral Computed / Q000379:methods*