title: Vanguards of paradigm shift in radiation biology: radiation-induced adaptive and bystander responses.
abstract: The risks of exposure to low dose ionizing radiation (below 100 mSv) are estimated by extrapolating from data obtained after exposure to high dose radiation, using a linear no-threshold model (LNT model). However, the validity of using this dose-response model is controversial because evidence accumulated over the past decade has indicated that living organisms, including humans, respond differently to low dose/low dose-rate radiation than they do to high dose/high dose-rate radiation. In other words, there are accumulated findings which cannot be explained by the classical "target theory" of radiation biology. The radioadaptive response, radiation-induced bystander effects, low-dose radio-hypersensitivity, and genomic instability are specifically observed in response to low dose/low dose-rate radiation, and the mechanisms underlying these responses often involve biochemical/molecular signals that respond to targeted and non-targeted events. Recently, correlations between the radioadaptive and bystander responses have been increasingly reported. The present review focuses on the latter two phenomena by summarizing observations supporting their existence, and discussing the linkage between them from the aspect of production of reactive oxygen and nitrogen species.
authors.affiliation: Division of Oncology, Biomedical Imaging Research Center, University of Fukui, Eiheiji, Japan. hidekim@fmsrsa.fukui-med.ac.jp
authors.forename: Hideki
authors.initials: H
authors.lastname: Matsumoto
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Hamada
authors.forename: Akihisa
authors.initials: A
authors.lastname: Takahashi
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Kobayashi
authors.forename: Takeo
authors.initials: T
authors.lastname: Ohnishi
mesh_terms: D000818:Animals; D024201:Bystander Effect; D004249:DNA Damage; D006801:Humans; D020935:MAP Kinase Signaling System; D009569:Nitric Oxide; D011829:Radiation Dosage; D011836:Radiation Tolerance; D011839:Radiation, Ionizing; D011853:Radiobiology; D011878:Radiotherapy / Q000379:methods*; D026361:Reactive Nitrogen Species; D017382:Reactive Oxygen Species
chemical_list: D026361:Reactive Nitrogen Species; D017382:Reactive Oxygen Species; D009569:Nitric Oxide