Psychiatric disorders in the parents of individuals with infantile autism: a case-control study.
BACKGROUND
The rates and types of psychiatric disorders were studied in the parents of individuals with infantile autism (IA).


METHODS
To estimate the prevalence and types of psychiatric disorders, the parents of 115 individuals with IA and the parents of 330 controls from the general population were screened through the nationwide Danish Psychiatric Central Register covering a period of 33 years. The IA individuals had been seen as in-patients at two university clinics of child psychiatry during a 25-year period and had been referred from the entire country of Denmark.


RESULTS
Psychiatric disorders were found in 15.7% of mothers with autistic children, which was significantly higher than the 8.2% found in the control group. The only diagnostic category in which a statistically significant overrepresentation could be found was that of personality disorder. A personality disorder diagnosis was found in 7.8% of mothers with autistic children in comparison to 2.1% of mothers in the control group.


CONCLUSIONS
The findings so far suggest that in future studies it is important to pay attention to issues such as relatives examined, control groups and methods of data collection.
Mouridsen
Svend Erik
SE
Department of Child and Adolescent Psychiatry, Bispebjerg Hospital, Copenhagen, Denmark. sem01@bbh.hosp.dk
Rich
Bente
B
Isager
Torben
T
Nedergaard
Niels Jørgen
NJ
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001321:Autistic Disorder / Q000453:epidemiology*; D016022:Case-Control Studies; D016241:Child of Impaired Parents / Q000523:psychology* / Q000706:statistics & numerical data*; D002675:Child, Preschool; D005260:Female; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000453:epidemiology* / Q000523:psychology / Q000534:rehabilitation; D008875:Middle Aged; D010290:Parents / Q000523:psychology*; D010343:Patient Admission / Q000706:statistics & numerical data; D012042:Registries