Frequency of CCR5 variants among rural populations with low HIV-1 prevalence in Cameroon.
Among rural populations in Cameroon, HIV-1 prevalence is low and the genetic diversity broad. An unusual population-level genetic background may modulate this pattern of HIV infection. We examined HIV-1 prevalence, CCR5Delta32 and CCR5 promoter -2459 G genotype frequency among 1390 rural inhabitants. No individual was identified with the CCR5Delta32 allele, but homozygotes for the CCR5 promoter variant -2459G (27.5%) were relatively common. A seroprevalence of 3.1% of HIV-1 was reported.
Torimiro
Judith N
JN
Walter Reed Johns Hopkins Cameroon Program, Yaounde, Cameroon. jtorimiro@hopkinscameroon.org
Wolfe
Nathan D
ND
Thomas
Alero
A
Martin
Maureen P
MP
Mpoudi-Ngole
Eitel
E
Tamoufe
Ubald
U
Birx
Deborah L
DL
Carrington
Mary
M
Burke
Donald S
DS
Carr
Jean K
JK
D002163:Cameroon / Q000453:epidemiology; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D015658:HIV Infections / Q000453:epidemiology / Q000235:genetics*; D015528:HIV Seroprevalence; D015497:HIV-1; D006801:Humans; D019713:Receptors, CCR5 / Q000235:genetics*; D012423:Rural Health / Q000706:statistics & numerical data
D019713:Receptors, CCR5