title: Progressive improvement of impaired visual acuity during the first year after transsphenoidal surgery for non-functioning pituitary macroadenoma.
abstract: OBJECTIVE
  Improvement of visual field defects continues even years after the initial surgical treatment. Because this process of continuing improvement has not been documented for visual acuity, we audited our data to explore the pattern of recovery of visual acuity until 1 year after transsphenoidal surgery for non-functioning pituitary macroadenoma.
  
  
  METHODS
  Retrospective follow-up study.
  
  
  METHODS
  Forty-three patients (mean age 56 +/- 14 years), treated by transsphenoidal surgery for non-functioning pituitary macroadenoma, were included in this analysis.
  
  
  RESULTS
  Visual acuity improved significantly within 3 months after transsphenoidal surgery. The mean visual acuity increased from 0.65 +/- 0.37 to 0.75 +/- 0.36 (P < 0.01) (right eye), and from 0.60 +/- 0.32 to 0.82 +/- 0.30 (P < 0.01) (left eye). Visual acuity was improved 1 year after transsphenoidal surgery compared to the 3 months postoperative values. The mean visual acuity increased from 0.75 +/- 0.36 to 0.82 +/- 0.34 (P < 0.05) (right eye), and from 0.82 +/- 0.30 to 0.88 +/- 0.27 (P < 0.05) (left eye).
  
  
  CONCLUSIONS
  Visual acuity improves progressively after surgical treatment for non-functioning pituitary macroadenomas, at least within the first year after transsphenoidal surgery.
authors.affiliation: Department of Endocrinology and Metabolic Diseases C4-R, Leiden University Medical Center, P.O. Box 9600, Leiden 2300 RC, The Netherlands. o.m.dekkers@lumc.nl
authors.forename: O M
authors.initials: OM
authors.lastname: Dekkers
authors.forename: R J W
authors.initials: RJ
authors.lastname: de Keizer
authors.forename: F
authors.initials: F
authors.lastname: Roelfsema
authors.forename: A A
authors.initials: AA
authors.lastname: Vd Klaauw
authors.forename: P J
authors.initials: PJ
authors.lastname: Honkoop
authors.forename: H
authors.initials: H
authors.lastname: van Dulken
authors.forename: J W A
authors.initials: JW
authors.lastname: Smit
authors.forename: J A
authors.initials: JA
authors.lastname: Romijn
authors.forename: A M
authors.initials: AM
authors.lastname: Pereira
mesh_terms: D000236:Adenoma / Q000601:surgery*; D000328:Adult; D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010911:Pituitary Neoplasms / Q000601:surgery*; D012189:Retrospective Studies; D014786:Vision Disorders / Q000503:physiopathology*; D014792:Visual Acuity; D014794:Visual Fields