title: [Mandibular advancement surgery in patients with severe obstructive sleep apnea uncontrolled by continuous positive airway pressure. A retrospective review of 25 patients between 1998 and 2004].
abstract: BACKGROUND
  Continuous positive airway pressure (CPAP) is ineffective in some patients with obstructive sleep apnoea syndrome (OSAS) and some patients do not tolerate it. This study evaluated the outcomes of maxillo-mandibular advancement in OSAS patients without morbid obesity or severe maxillo-mandibular deformity who had first been treated with CPAP for at least 6 months.
  
  
  METHODS
  A retrospective study reporting on the experience of the CHU Toulouse Rangueil sleep disorder centre between 1998 and 2004. We performed polysomnography and cephalometry before and 3 months after surgery.
  
  
  RESULTS
  25 male patients with mean apnoea hypopnoea index at 45/hour (+/-15) were treated by maxillo-mandibular advancement. The mean age of participants was 48 years (+/-7), and the mean body mass index was 28 kg/m2 (+/-3.4). Cephalometry demonstrated a retroposition of the mandible (SNB < 80 degrees +/-5) and narrow linguopharyngeal space (ELP = 8 mm+/-3). 3 months after surgery the apnoea hypopnoea index (AHI) had decreased from 45+/-15 to 7+/-7 (p < 0.0001), the Epworth sleepiness scale decreased from 11+/-5 to 6+/-4 (p < 0.01). The linguopharyngeal space was larger (ELP = 14 mm). Success rate defined as an AHI < 15/hour was 89%, and 74% for an AHI < 10/hour. 16 patients underwent polysomnography one year after surgery. The results were the same. There were no post surgical complications, except for one patient who developed permanent labial hypoesthesia.
  
  
  CONCLUSIONS
  Maxillo-mandibular advancement seems to be an effective 2nd line therapy for the treatment of severe OSAS.
authors.affiliation: Consultation multidisciplinaire des troubles du sommeil, CHU Toulouse Rangueil, France.
authors.forename: C
authors.initials: C
authors.lastname: Dekeister
authors.forename: L
authors.initials: L
authors.lastname: Lacassagne
authors.forename: M
authors.initials: M
authors.lastname: Tiberge
authors.forename: T
authors.initials: T
authors.lastname: Montemayor
authors.forename: M
authors.initials: M
authors.lastname: Migueres
authors.forename: J R
authors.initials: JR
authors.lastname: Paoli
mesh_terms: D000328:Adult; D002508:Cephalometry; D045422:Continuous Positive Airway Pressure; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D019186:Mandibular Advancement / Q000379:methods*; D008875:Middle Aged; D017060:Patient Satisfaction; D017286:Polysomnography; D012189:Retrospective Studies; D020181:Sleep Apnea, Obstructive / Q000601:surgery*; D016896:Treatment Outcome