title: Recurrent vasculopathic skin lesions associated with homozygous protein C deficiency.
abstract: Symptomatic protein C deficiency is a rare condition. Vasculopathy associated with hypercoagulable state in protein C deficiency has also been reported rarely. We described a boy who was diagnosed as having homozygous protein C deficiency during the neonatal period, when he developed purpura fulminans. At 7 years of age, he developed recurrent, painful, nonscarring, purpuric skin lesions. Histopathologic skin findings were compatible with those of vasculopathy. The histopathologic characteristics of these vasculopathic lesions and the pathogenetic mechanisms of their association with protein C deficiency are discussed.
authors.affiliation: Baskent University Department of Pediatric Nephrology, 6 Cadde No. 72/3, Bahcelievler, 06490 Ankara, Turkey. pinaris2001@yahoo.com
authors.forename: Pinar Isik
authors.initials: PI
authors.lastname: Agras
authors.forename: Handan
authors.initials: H
authors.lastname: Ozdemir
authors.forename: Esra
authors.initials: E
authors.lastname: Baskin
authors.forename: Namik
authors.initials: N
authors.lastname: Ozbek
mesh_terms: D002648:Child; D006801:Humans; D008297:Male; D016491:Peripheral Vascular Diseases / Q000150:complications* / Q000473:pathology; D020151:Protein C Deficiency / Q000150:complications*; D011693:Purpura / Q000209:etiology* / Q000473:pathology; D012008:Recurrence