No association between the glutamate decarboxylase 67 gene (GAD1) and schizophrenia in the Japanese population.
Postmortem studies regarding schizophrenia revealed altered expression of genes related to gamma-amino butyric acid neurotransmission system. One of the most consistent findings is the reduced level of 67 kDa glutamic acid decarboxylase isoform (GAD(67)). Moreover, several studies reported positive associations between the GAD(67) gene (GAD1) and schizophrenia. These reasons, motivated us to carry out replication study regarding association between GAD1 (fourteen tagging SNPs) and schizophrenia in Japanese population (562 schizophrenic patients and 470 controls). However we couldn't confirm significant association that had been previously reported. Considering size of our sample and strategy that corresponds well with the approaches used in gene-based association analysis, our conclusion is that GAD1 does not play a major role in schizophrenia in Japanese population.
Ikeda
Masashi
M
Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi 470-1192, Japan. ikeda-ma@fujita-hu.ac.jp
Ozaki
Norio
N
Yamanouchi
Yoshio
Y
Suzuki
Tatsuyo
T
Kitajima
Tsuyoshi
T
Kinoshita
Yoko
Y
Inada
Toshiya
T
Iwata
Nakao
N
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People / Q000235:genetics* / Q000706:statistics & numerical data*; D005260:Female; D015870:Gene Expression / Q000235:genetics*; D005819:Genetic Markers; D005838:Genotype; D005968:Glutamate Decarboxylase / Q000235:genetics* / Q000378:metabolism*; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D007527:Isoenzymes / Q000235:genetics* / Q000378:metabolism*; D007564:Japan; D015810:Linkage Disequilibrium / Q000235:genetics; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D012559:Schizophrenia / Q000208:ethnology* / Q000235:genetics*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D005819:Genetic Markers; D007527:Isoenzymes; D005680:gamma-Aminobutyric Acid; D005968:Glutamate Decarboxylase; C402565:glutamate decarboxylase 1