title: Pick's disease with Pick bodies: an unusual autopsy case showing degeneration of the pontine nucleus, dentate nucleus, Clarke's column, and lower motor neuron.
abstract: We report a 51-year-old female with Pick's disease with Pick bodies (PDPB) showing a brainweight of 530 g. This case was considered to be a very rare case of PDPB, in which the lesion developed in the temporal and frontal lobes and later spread to the parietal lobe, occipital lobe, brainstem, cerebellum and spinal cord. This case showed very atypical clinicopathological findings. Clinically, bulging eyes and myoclonus were observed. Neuropathologically, Pick bodies were widely distributed beyond the usual distribution areas to the parietal cortices, occipital cortices, dentate nuclei, motor neuron nuclei in the brain stem, and spinal cord. The atypical clinical symptoms and the widespread neuropathological abnormalities observed in this case seem to represent an extremely extended form of PDPB.
authors.affiliation: Department of Psychiatry, National Hospital Organization Shimofusa Psychiatric Medical Center, Chiba, Japan. oda@chiba-net.or.jp
authors.forename: Tatsuro
authors.initials: T
authors.lastname: Oda
authors.forename: Kuniaki
authors.initials: K
authors.lastname: Tsuchiya
authors.forename: Tetsuaki
authors.initials: T
authors.lastname: Arai
authors.forename: Takashi
authors.initials: T
authors.lastname: Togo
authors.forename: Hirotake
authors.initials: H
authors.lastname: Uchikado
authors.forename: Rohan
authors.initials: R
authors.lastname: de Silva
authors.forename: Andrew
authors.initials: A
authors.lastname: Lees
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Akiyama
authors.forename: Chie
authors.initials: C
authors.lastname: Haga
authors.forename: Kenji
authors.initials: K
authors.lastname: Ikeda
authors.forename: Motoichiro
authors.initials: M
authors.lastname: Kato
authors.forename: Yuji
authors.initials: Y
authors.lastname: Kato
authors.forename: Tsunekatsu
authors.initials: T
authors.lastname: Hara
authors.forename: Mitsumoto
authors.initials: M
authors.lastname: Onaya
authors.forename: Koji
authors.initials: K
authors.lastname: Hori
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Teramoto
authors.forename: Itaru
authors.initials: I
authors.lastname: Tominaga
mesh_terms: D017668:Age of Onset; D001344:Autopsy; D001921:Brain / Q000473:pathology*; D002529:Cerebellar Nuclei / Q000473:pathology; D005094:Exophthalmos / Q000209:etiology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D009046:Motor Neurons / Q000473:pathology*; D009207:Myoclonus / Q000209:etiology; D020774:Pick Disease of the Brain / Q000150:complications / Q000473:pathology* / Q000503:physiopathology*; D011149:Pons / Q000473:pathology; D014057:Tomography, X-Ray Computed