title: Considerations of the ischemic basis and therapy of Alzheimer Disease.
abstract: A recently presented concept of Alzheimer disease (AD) is based on a primarily ischemic (rather than degenerative) type of brain disease. Etiologically, this new concept is presumed to be related to the human upright gait along with individual predisposition. The proposed treatment--head-down therapy (HDT) --is the centerpoint of this presentation: a simple and generally accessible type of therapy, with monitoring by neuropsychological questioning, electroencephalography, and transcranial Doppler. As a treatment of AD (limited to stage 1), HDT is expected to be helpful. It is possible, however, that its prophylactic use may be of even greater importance.
authors.affiliation: Department of Neurology, The Johns Hopkins University School of Medicine, The Sinai Hospital, Baltimore, Maryland, USA.
authors.forename: E
authors.initials: E
authors.lastname: Niedermeyer
mesh_terms: D000544:Alzheimer Disease / Q000209:etiology* / Q000628:therapy*; D002545:Brain Ischemia / Q000150:complications* / Q000628:therapy*; D019317:Evidence-Based Medicine; D006801:Humans; D026741:Physical Therapy Modalities; D011187:Posture