title: Pneumatic dilatation or laparoscopic cardiomyotomy in the management of newly diagnosed idiopathic achalasia. Results of a randomized controlled trial.
abstract: BACKGROUND
  The most effective therapeutic strategy in newly diagnosed achalasia is yet to be established. Therefore we designed a study in which pneumatic dilatation was compared to laparoscopic cardiomyotomy to which was added a partial posterior fundoplication.
  
  
  RESULTS
  A series of 51 patients (24 males, mean age 44 years) were randomly allocated to the therapeutic modalities (dilatation = 26, surgery = 25). All patients were followed for at least 12 months, and during that period the pneumatic dilatations strategy had significantly more treatment failures (P = 0.04). Only minor differences emerged between the study groups when symptoms, dysphagia scorings, and quality-of-life assessments were evaluated 12 months after initiation of therapy.
  
  
  CONCLUSIONS
  Laparoscopic myotomy was found to be superior to an endoscopic balloon dilatation strategy in the treatment of achalasia when studied during the first 12 months after treatment.
authors.affiliation: Department of General Surgery, Borås Central Hospital, Brämhultsvägen 53, S-501 82, Borås, Sweden. srdjan.kostic@vgregion.se
authors.forename: S
authors.initials: S
authors.lastname: Kostic
authors.forename: A
authors.initials: A
authors.lastname: Kjellin
authors.forename: M
authors.initials: M
authors.lastname: Ruth
authors.forename: H
authors.initials: H
authors.lastname: Lönroth
authors.forename: E
authors.initials: E
authors.lastname: Johnsson
authors.forename: M
authors.initials: M
authors.lastname: Andersson
authors.forename: L
authors.initials: L
authors.lastname: Lundell
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002299:Cardia / Q000601:surgery; D002404:Catheterization / Q000379:methods*; D004931:Esophageal Achalasia / Q000601:surgery / Q000628:therapy*; D005260:Female; D018662:Fundoplication; D006801:Humans; D010535:Laparoscopy; D008297:Male; D008365:Manometry; D008875:Middle Aged; D011788:Quality of Life; D018709:Statistics, Nonparametric; D017211:Treatment Failure; D016896:Treatment Outcome