title: Randomized controlled trial of fosmidomycin-clindamycin versus sulfadoxine-pyrimethamine in the treatment of Plasmodium falciparum malaria.
abstract: Fosmidomycin-clindamycin therapy given every 12 h for 3 days was compared with a standard single oral dose of sulfadoxine-pyrimethamine. The two treatments showed comparably good tolerabilities and had an identical high degree of efficacy of 94% in a randomized trial carried out with 105 Gabonese children aged 3 to 14 years with uncomplicated malaria. These antimalarials merit further clinical exploration.
authors.affiliation: Institute for Tropical Medicine, Department for Parasitology, University of Tübingen, Wilhelmstrasse 27, Tübingen, Germany.
authors.forename: Sunny
authors.initials: S
authors.lastname: Oyakhirome
authors.forename: Saadou
authors.initials: S
authors.lastname: Issifou
authors.forename: Peter
authors.initials: P
authors.lastname: Pongratz
authors.forename: Fortune
authors.initials: F
authors.lastname: Barondi
authors.forename: Michael
authors.initials: M
authors.lastname: Ramharter
authors.forename: Jürgen F
authors.initials: JF
authors.lastname: Kun
authors.forename: Michel A
authors.initials: MA
authors.lastname: Missinou
authors.forename: Bertrand
authors.initials: B
authors.lastname: Lell
authors.forename: Peter G
authors.initials: PG
authors.lastname: Kremsner
mesh_terms: D000293:Adolescent; D000962:Antimalarials / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D002981:Clindamycin / Q000008:administration & dosage*; D004338:Drug Combinations; D005260:Female; D005578:Fosfomycin / Q000008:administration & dosage / Q000031:analogs & derivatives*; D006801:Humans; D016778:Malaria, Falciparum / Q000188:drug therapy*; D008297:Male; D011739:Pyrimethamine / Q000627:therapeutic use*; D013413:Sulfadoxine / Q000627:therapeutic use*
chemical_list: D000962:Antimalarials; D004338:Drug Combinations; D005578:Fosfomycin; C001205:fanasil, pyrimethamine drug combination; D002981:Clindamycin; C024640:fosmidomycin; D013413:Sulfadoxine; D011739:Pyrimethamine