title: Room temperature zinc chloride-catalyzed cycloisomerization of Alk-3-yn-1-ones: synthesis of substituted furans.
abstract: [structure: see text]. 5-Endo-dig cycloisomerization of 1,4-di- and 1,2,4-trisubstituted but-3-yn-1-ones in the presence of a catalytic amount of zinc chloride (10 mol %) in dichloromethane at room temperature (22 degrees C) provides 2,5-di- and 2,3,5-trisubstituted furans in high yields (85-97%).
authors.affiliation: Department of Chemistry, Oakland University, Rochester, MI 48309-4477, USA.
authors.forename: Adam
authors.initials: A
authors.lastname: Sniady
authors.forename: Audrey
authors.initials: A
authors.lastname: Durham
authors.forename: Marco S
authors.initials: MS
authors.lastname: Morreale
authors.forename: Kraig A
authors.initials: KA
authors.lastname: Wheeler
authors.forename: Roman
authors.initials: R
authors.lastname: Dembinski