title: Immuno-parasitological assessment of bancroftian filariasis in a highly endemic area along the River Sabaki, in Malindi district, Kenya.
abstract: Lymphatic filariasis is endemic in the coastal areas of Kenya, with four major foci identified in the early 1970s. The prevalence and intensity of Wuchereria bancrofti infection, together with antifilarial antibody responses, were assessed in a historically highly endemic focus along the River Sabaki, in Malindi district. The prevalences of microfilaraemia and antigenaemia (detected by Og4C3 ELISA) were >20% and >40%, respectively, and both increased steadily with age. The high prevalences of antifilarial IgG1 (86%) and IgG4 (91%) responses indicate that most people living in this setting are exposed to W. bancrofti infection. The children investigated had higher levels of antifilarial IgG1 than the adults. The results of this study, based on a battery of currently available parasitological and immunological methods, provide an epidemiological update on lymphatic filariasis on the northern Kenyan coast. They show that the River Sabaki area is still an important focus for bancroftian filariasis and highlight the importance of implementing an elimination programme, to interrupt the transmission of W. bancrofti in all areas of endemicity in Kenya. The detailed baseline data collected in the River Sabaki area make the communities studied ideal as sentinel sites for epidemiological monitoring and the evaluation of the impact of mass drug administrations to eliminate lymphatic filariasis.
authors.affiliation: Kenya Medical Research Institute (KEMRI), P.O. Box 54840, Mbagathi Road, Nairobi, Kenya. snjenga@kemri-nuitm.or.ke
authors.forename: S M
authors.initials: SM
authors.lastname: Njenga
authors.forename: C N
authors.initials: CN
authors.lastname: Wamae
authors.forename: C S
authors.initials: CS
authors.lastname: Mwandawiro
authors.forename: D H
authors.initials: DH
authors.lastname: Molyneux
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D000909:Antibodies, Helminth / Q000276:immunology*; D000918:Antibody Specificity / Q000276:immunology*; D000947:Antigens, Helminth / Q000276:immunology*; D004605:Elephantiasis, Filarial / Q000453:epidemiology / Q000276:immunology* / Q000469:parasitology; D019353:Endemic Diseases; D005260:Female; D006801:Humans; D007630:Kenya / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D014958:Wuchereria bancrofti / Q000276:immunology* / Q000469:parasitology
chemical_list: D000909:Antibodies, Helminth; D000947:Antigens, Helminth