title: A booster vaccination with Mycobacterium bovis BCG does not increase the protective effect of the vaccine against experimental Mycobacterium ulcerans infection in mice.
abstract: Buruli ulcer, caused by Mycobacterium ulcerans, is a necrotizing skin disease emerging particularly in West Africa. M. bovis BCG vaccine offers only short-term protection against experimental footpad infection of C57BL/6 mice with M. ulcerans, and the duration of this protection cannot be prolonged by a booster vaccination.
authors.affiliation: Mycobacterial Immunology, WIV-Pasteur Institute Brussels, 642 Engelandstraat, B-1180 Brussels, Belgium.
authors.forename: Audrey
authors.initials: A
authors.lastname: Tanghe
authors.forename: Pierre-Yves
authors.initials: PY
authors.lastname: Adnet
authors.forename: Tatiana
authors.initials: T
authors.lastname: Gartner
authors.forename: Kris
authors.initials: K
authors.lastname: Huygen
mesh_terms: D000818:Animals; D001500:BCG Vaccine / Q000008:administration & dosage* / Q000276:immunology; D004195:Disease Models, Animal; D005528:Foot / Q000382:microbiology; D006801:Humans; D007117:Immunization, Secondary; D051379:Mice; D008810:Mice, Inbred C57BL; D009165:Mycobacterium Infections, Nontuberculous / Q000382:microbiology / Q000401:mortality / Q000517:prevention & control*; D009163:Mycobacterium bovis / Q000276:immunology*; D019911:Mycobacterium ulcerans / Q000472:pathogenicity*
chemical_list: D001500:BCG Vaccine