Benefits and risks of mitomycin use in the traumatized tracheal mucosa.
OBJECTIVE
To investigate the efficacy and early complications of mitomycin C (MMC) in tracheal wound models.


METHODS
Rabbits (N = 60) were randomized to undergo mucosal injuries to the upper and lower trachea including anterior 120 degrees full thickness (group A, n = 20), anterior 120 degrees partial thickness (group B, 20), and circumferential partial thickness (group C, 20). In each rabbit, the wounds were separately treated with MMC 1.0 mg/mL or saline, and the animals were sacrificed after three weeks.


RESULTS
Twenty-seven of the 60 animals experienced early death because of tracheal rupture or airway obstruction caused by unresolved scabs on the preinjured tracheal mucosa; the incidence of early death was higher in groups A and C than in group B. In each group, the degree of tracheal stenosis was comparable in wounds treated with MMC and saline.


CONCLUSIONS
These findings suggest that topical MMC has no benefit when used to prevent tracheal stenosis. Acute airway obstruction may occur in MMC-treated rabbits with tracheal wounds.
Roh
Jong-Lyel
JL
Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
Kim
Dong Hyun
DH
Rha
Ki Sang
KS
Sung
Myung-Whun
MW
Kim
Kwang Hyun
KH
Park
Chan Il
CI
D000402:Airway Obstruction / Q000209:etiology; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000009:adverse effects / Q000627:therapeutic use*; D002423:Cause of Death; D002921:Cicatrix / Q000209:etiology; D004195:Disease Models, Animal; D005260:Female; D016685:Mitomycin / Q000009:adverse effects / Q000627:therapeutic use*; D009336:Necrosis; D011817:Rabbits; D011897:Random Allocation; D020545:Respiratory Mucosa / Q000293:injuries* / Q000601:surgery; D018570:Risk Assessment; D012422:Rupture, Spontaneous; D013536:Suture Techniques; D014132:Trachea / Q000293:injuries* / Q000601:surgery; D014135:Tracheal Stenosis / Q000209:etiology
D000903:Antibiotics, Antineoplastic; D016685:Mitomycin