title: Adverse drug events resulting from patient errors in older adults.
abstract: OBJECTIVE
  To characterize the types of patient-related errors that lead to adverse drug events (ADEs) and identify patients at high risk of such errors.
  
  
  METHODS
  A subanalysis within a cohort study of Medicare enrollees.
  
  
  METHODS
  A large multispecialty group practice.
  
  
  METHODS
  Thirty thousand Medicare enrollees followed over a 12-month period.
  
  
  METHODS
  Primary outcomes were ADEs, defined as injuries due to a medication, and potential ADEs, defined as medication errors with the potential to cause an injury. The subset of these events that were related to patient errors was identified.
  
  
  RESULTS
  The majority of patient errors leading to adverse events (n=129) occurred in administering the medication (31.8%), modifying the medication regimen (41.9%), or not following clinical advice about medication use (21.7%). Patient-related errors most often involved hypoglycemic medications (28.7%), cardiovascular medications (21.7%), anticoagulants (18.6%), or diuretics (10.1%). Patients with medication errors did not differ from a comparison group in age or sex but were taking more regularly scheduled medications (compared with 0-2 medications, odds ratio (OR) for 3-4 medications=2.0, 95% confidence interval (CI)=0.9-4.2; OR for 5-6 medications=3.1, 95% CI=1.5-7.0; OR for >or=7 medications=3.3, 95% CI=1.5-7.0). The strongest association was with the Charlson Comorbidity Index (compared with a score of 0, OR for a score of 1-2=3.8, 95% CI=2.1-7.0; OR for a score of 3-4=8.6, 95% CI=4.3-17.0; OR for a score of >or=5=15.0, 95% CI=6.5-34.5).
  
  
  CONCLUSIONS
  The medication regimens of older adults present a range of difficulties with the potential for harm. Strategies are needed that specifically address the management of complex drug regimens.
authors.affiliation: Meyers Primary Care Institute, Worcester, Massachusetts 01605, USA. tfield@meyersprimary.org
authors.forename: Terry S
authors.initials: TS
authors.lastname: Field
authors.forename: Kathleen M
authors.initials: KM
authors.lastname: Mazor
authors.forename: Becky
authors.initials: B
authors.lastname: Briesacher
authors.forename: Kristin R
authors.initials: KR
authors.lastname: Debellis
authors.forename: Jerry H
authors.initials: JH
authors.lastname: Gurwitz
mesh_terms: D016907:Adverse Drug Reaction Reporting Systems; D000368:Aged; D000369:Aged, 80 and over; D015897:Comorbidity; D064420:Drug-Related Side Effects and Adverse Reactions; D005260:Female; D006801:Humans; D008297:Male; D008508:Medication Errors / Q000706:statistics & numerical data*; D004364:Pharmaceutical Preparations / Q000008:administration & dosage; D019338:Polypharmacy; D012646:Self Administration
chemical_list: D004364:Pharmaceutical Preparations