title: Recurrent non-typhoidal salmonella bacteremia in a patient with interleukin -12p40 deficiency.
abstract: The South eastern region of Iran is an endemic area for salmonellosis. Sometimes bacteremia due to nontyphoidal salmonella occurs but certain patients are at increased risk for recurrent bacteremia. The risk of invasive salmonellosis and recurrent bacteremia is increased in the patients with immunosuppression, especially impaired cell-mediated immunity, lymphoproliferative diseases and in patients with IL-12 deficiency. In recent years, a series of inherited disorders of IL-12-IFN-gamma axis have been described that predispose affected individuals to disseminated disease caused by environmental mycobacteria and non-typhoidal salmonella. We report here the first such patient originating from and living in Iran. The patient was a 26-year-old man, suffering from IL-12p40 deficiency and presented with recurrent episodes of systemic salmonellosis. This report indicates that there are patients with inherited defects of the IL-12-IFN-gamma circuit in Iran. We recommended to consider this group of disorders in all patients with recurrent non-typhoidal salmonella bacteremia, wherever they are found.
authors.affiliation: Department of Infectious Diseases, Boo-Ali Hospital, Zahedan, Iran. batoolsharifi@yahoo.com.
authors.forename: Batool
authors.initials: B
authors.lastname: Sharifi Mood
authors.forename: Minoo
authors.initials: M
authors.lastname: Mohraz
authors.forename: Seyed Davood
authors.initials: SD
authors.lastname: Mansouri
authors.forename: Roya
authors.initials: R
authors.lastname: Alavi Naini
authors.forename: Hamid Reza
authors.initials: HR
authors.lastname: Kouhpayeh
authors.forename: Mohammad
authors.initials: M
authors.lastname: Naderi
authors.forename: Orchidce Filipe
authors.initials: OF
authors.lastname: Santos
authors.forename: Guillaume
authors.initials: G
authors.lastname: Vogt
authors.forename: Ariane
authors.initials: A
authors.lastname: Chapgicr
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Feinberg
authors.forename: Jean Laurent
authors.initials: JL
authors.lastname: Casanova
authors.forename: Taghi
authors.initials: T
authors.lastname: Naserpoor