Transverse myelopathy following intrathecal administration of chemotherapy.
Transverse myelopathy is one of the rare complications following administration of intrathecal chemotherapy. We report two cases of transverse myelopathy following administration of intrathecal methotrexate and cytarabine arabinoside. One patient was a 17-year-old Malay man who had lymphoblastic lymphoma in the leukaemic phase, while the other patient was a 40-year-old Malay man with relapsed Hodgkin's lymphoma. Both cases demonstrated variability in onset of symptoms, clinical progression and final outcome from the complication.
Teh
H S
HS
Haematology Unit, Department of Medicine, Faculty of Medicine, University Kebangsaan Malaysia, Jalan Yaacob Latif, Bandar Tun Razak, Cheras, Kuala Lumpur 56000, Malaysia. hiokseng2005@gmail.com
Fadilah
S A W
SA
Leong
C F
CF
D000293:Adolescent; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000009:adverse effects*; D003561:Cytarabine / Q000009:adverse effects*; D017809:Fatal Outcome; D006689:Hodgkin Disease / Q000188:drug therapy; D006801:Humans; D007278:Injections, Spinal; D017254:Leukemic Infiltration / Q000188:drug therapy; D008297:Male; D008727:Methotrexate / Q000009:adverse effects*; D009188:Myelitis, Transverse / Q000139:chemically induced*; D036102:Peripheral Blood Stem Cell Transplantation; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy
D003561:Cytarabine; D008727:Methotrexate