Molecular phylogeny of modern coxsackievirus A16.
A phylogenetic analysis of VP1 and VP4 nucleotide sequences of 52 recent CVA16 strains demonstrated two distinct CVA16 genogroups, A and B, with the prototype strain being the only member of genogroup A. CVA16 G-10, the prototype strain, showed a nucleotide difference of 27.7-30.2% and 19.9-25.2% in VP1 and VP4, respectively, in relation to other CVA16 strains, which formed two separate lineages in genogroup B with nucleotide variation of less than 13.4% and less than 16.3% in VP1 and VP4, respectively. Lineage 1 strains circulating before 2000 were later displaced by lineage 2 strains.
Perera
D
D
Institute of Health and Community Medicine, Universiti Malaysia Sarawak, Sarawak, Malaysia.
Yusof
M A
MA
Podin
Y
Y
Ooi
M H
MH
Thao
N T T
NT
Wong
K K
KK
Zaki
A
A
Chua
K B
KB
Malik
Y A
YA
Tu
P V
PV
Tien
N T K
NT
Puthavathana
P
P
McMinn
P C
PC
Cardosa
M J
MJ
D001483:Base Sequence; D036022:Capsid Proteins / Q000235:genetics; D017931:DNA Primers / Q000235:genetics; D004279:DNA, Viral / Q000235:genetics; D029821:Enterovirus A, Human / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D019143:Evolution, Molecular; D006232:Hand, Foot and Mouth Disease / Q000821:virology; D006801:Humans; D008969:Molecular Sequence Data; D010802:Phylogeny; D015678:Viral Structural Proteins / Q000235:genetics
D036022:Capsid Proteins; D017931:DNA Primers; D004279:DNA, Viral; D015678:Viral Structural Proteins