The Fanconi anemia signalosome anchor.
FAAP24, a new XPF endonuclease family member identified by in a recent issue of Molecular Cell, heterodimerizes with FANCM, binds unwound DNA, and reveals how the Fanconi anemia core complex concentrates DNA repair proteins at stalled replication forks.
Niedernhofer
Laura J
LJ
Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine and Cancer Institute, Pittsburgh, PA 15213, USA. niedernhoferl@upmc.edu
D000818:Animals; D004261:DNA Replication; D019281:Dimerization; D004720:Endonucleases / Q000378:metabolism; D005199:Fanconi Anemia / Q000201:enzymology / Q000378:metabolism* / Q000473:pathology*; D051856:Fanconi Anemia Complementation Group Proteins / Q000378:metabolism; D006367:HeLa Cells; D006801:Humans; D015398:Signal Transduction
D051856:Fanconi Anemia Complementation Group Proteins; D004720:Endonucleases