title: Glycogen synthase kinase 3beta (GSK3beta) regulates differentiation and proliferation in neural stem cells from the rat subventricular zone.
abstract: On the basis of its inhibition by SB216763, we identified the multifunctional enzyme Glycogen Synthase Kinase 3beta (GSK3beta) as a central regulator for differentiation and cell survival of adult neural stem cells. Detected by proteomic approaches, members of the Wnt/beta-catenin signaling pathway appear to participate in enhanced neuronal differentiation and activated transcription of beta-catenin target genes during GSK3beta inhibition, associated with decreased apoptosis.
authors.affiliation: Department of Physiology and Pathophysiology, Division of Systems Physiology, University of Heidelberg, Im Neuenheimer Feld 326, 69120 Heidelberg, Germany. maurer@physiologie.uni-heidelberg.de
authors.forename: Martin H
authors.initials: MH
authors.lastname: Maurer
authors.forename: Jens O
authors.initials: JO
authors.lastname: Brömme
authors.forename: Robert E
authors.initials: RE
authors.lastname: Feldmann
authors.forename: Anne
authors.initials: A
authors.lastname: Järve
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Sabouri
authors.forename: Heinrich F
authors.initials: HF
authors.lastname: Bürgers
authors.forename: Dominik W
authors.initials: DW
authors.lastname: Schelshorn
authors.forename: Carola
authors.initials: C
authors.lastname: Krüger
authors.forename: Armin
authors.initials: A
authors.lastname: Schneider
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Kuschinsky
mesh_terms: D000818:Animals; D017209:Apoptosis; D002454:Cell Differentiation; D049109:Cell Proliferation; D002552:Cerebral Ventricles / Q000166:cytology*; D015180:Electrophoresis, Gel, Two-Dimensional; D038362:Glycogen Synthase Kinase 3 / Q000502:physiology*; D000071679:Glycogen Synthase Kinase 3 beta; D009474:Neurons / Q000166:cytology* / Q000201:enzymology; D040901:Proteomics / Q000379:methods; D051381:Rats; D013234:Stem Cells / Q000166:cytology* / Q000201:enzymology; D051153:Wnt Proteins / Q000378:metabolism; D051176:beta Catenin / Q000235:genetics / Q000378:metabolism
chemical_list: D051153:Wnt Proteins; D051176:beta Catenin; D000071679:Glycogen Synthase Kinase 3 beta; C000605508:Gsk3b protein, rat; D038362:Glycogen Synthase Kinase 3