Extradural spinal meningioma as a source of plasmacytoid cells. A case report.
BACKGROUND
Meningiomas, tumors that often affect middle-aged and elderly people, occasionally arise in the spine, typically at the thoracic level. The cytologic findings in meningiomas include whorls and syncytial clusters of bland-looking cells with scattered, psammomatous calcifications and intranudclear cytoplasmic inclusions. However, in many cases, not all these findings are seen, and in rare cases, unusual cytomorphologic features are observed.


METHODS
A case of spinal meningioma was located in the extradural compartment and composed predominantly of singly scattered cells with a plasmacytoid appearance, demonstrated on fine needle aspiration biopsy smear preparations. The cell block showed more typical features of meningioma, and the diagnosis was supported by the results of immunohistochemical staining.


CONCLUSIONS
The diagnosis of spinal meningioma is readily made by employing magnetic resonance imaging. The diagnosis can be difficult to confirm pathologically when atypical histologic findings are present, as in this case, with prominent plasmacytoid features. Sections from the cell block and immunohistochemical stains as well as clinical and radiologic findings were extremely helpful in arriving at the final diagnosis.
Nicolas
Marlo M
MM
Department of Pathology and Radiology, Feinberg School of Medicine, Northwestern University, Northwestern Memorial Hospital, Chicago, Illinois, USA. mmnicola@mdanderson.org
Kaakaji
Rami
R
Russell
Eric J
EJ
De Frias
Denise V
DV
Nayar
Ritu
R
D044963:Biopsy, Fine-Needle; D015174:Epidural Neoplasms / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008579:Meningioma / Q000175:diagnosis* / Q000473:pathology; D008875:Middle Aged; D010954:Plasmacytoma / Q000473:pathology; D013904:Thoracic Vertebrae