Acid-catalyzed synthesis of oxathiolone fused chalcones. Comparison of their activity toward various microorganisms and human cancer cells line.
Substituted oxathiolone fused chalcones were prepared by condensation of 4-acetyl-5-methoxy-2-oxo-benz[1,3]oxathiole with benzaldehydes under acidic conditions. The compounds were tested for cytotoxic, antibacterial, antifungal and tuberculostatic activity. Three derivatives demonstrated weak activity against HeLa cells, two were slightly active against Micrococcus luteus and Staphylococcus aureus, and one was active against Mycobacterium tuberculosis H(37)Rv.
Konieczny
Marek T
MT
Department of Organic Chemistry, Medical University of Gdańsk, Faculty of Pharmacy, Gdańsk, Poland. markon@amg.gda.pl
Konieczny
Wojciech
W
Sabisz
Michał
M
Skladanowski
Andrzej
A
Wakieć
Roland
R
Augustynowicz-Kopeć
Ewa
E
Zwolska
Zofia
Z
D000143:Acids / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002384:Catalysis; D047188:Chalcones / Q000138:chemical synthesis* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D006801:Humans; D008826:Microbial Sensitivity Tests; D013871:Thiones / Q000737:chemistry*
D000143:Acids; D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D047188:Chalcones; D013871:Thiones