title: Synthesis and antimicrobial evaluation of some new thiazole, thiazolidinone and thiazoline derivatives starting from 1-chloro-3,4-dihydronaphthalene-2-carboxaldehyde.
abstract: The thiosemicarbazones (3 and 6) and N-arylidene cyanoacetohydrazide (12) were prepared and used as key intermediates for the synthesis of 4-thiazolidinones (4, 5, 7-9), thiazoles (10a,b and 11a-d) and thiazoline (13) derivatives. Treatment of 13 with a mixture of triethylorthoformate and acetic anhydride afforded thiazolo[5,4-d]pyrimidinone derivative (14). The newly synthesized compounds were characterized by IR, (1)H NMR and mass spectral studies. Representative compounds of the synthesized products were tested and evaluated as antimicrobial agents.
authors.affiliation: Department of Chemistry, Faculty of Science, Mansoura University, El-gomhuria street, El-Dakhlia, ET-35516 Mansoura, Egypt. Bondock@mans.edu.eg
authors.forename: Samir
authors.initials: S
authors.lastname: Bondock
authors.forename: Wesam
authors.initials: W
authors.lastname: Khalifa
authors.forename: Ahmed A
authors.initials: AA
authors.lastname: Fadda
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005658:Fungi / Q000187:drug effects; D015394:Molecular Structure; D009281:Naphthalenes / Q000737:chemistry*; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: C522582:1-chloro-3,4-dihydronaphthalene-2-carboxaldehyde; D000447:Aldehydes; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D009281:Naphthalenes; D013844:Thiazoles