Chronic thyroxine treatment activates the 5-HT2A serotonin receptor in the mouse brain.
Chronic thyroxine administration (2.0 mg/l, 60 days) significantly increases the 5-HT2A serotonin receptor gene mRNA level in the frontal cortex and augments the frequency of head twitches induced by the receptor agonist DOI (1.0 mg/kg, i.p.) in AKR mice. The result indicates thyroid hormones involvement in 5-HT2A receptor regulation in adult brain.
Kulikov
A V
AV
Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Avenue Lavrentyev, 10, 630090 Novosibirsk, Russia. akulikov@ngs.ru
Zubkov
E A
EA
D000662:Amphetamines / Q000494:pharmacology; D000704:Analysis of Variance; D000818:Animals; D001921:Brain / Q000187:drug effects*; D004334:Drug Administration Schedule; D004347:Drug Interactions; D005786:Gene Expression Regulation / Q000187:drug effects*; D008297:Male; D051379:Mice; D008806:Mice, Inbred AKR; D012333:RNA, Messenger / Q000096:biosynthesis; D044402:Receptor, Serotonin, 5-HT2A / Q000235:genetics / Q000378:metabolism*; D020133:Reverse Transcriptase Polymerase Chain Reaction / Q000379:methods; D017366:Serotonin Receptor Agonists / Q000494:pharmacology; D013974:Thyroxine / Q000494:pharmacology*
D000662:Amphetamines; D012333:RNA, Messenger; D044402:Receptor, Serotonin, 5-HT2A; D017366:Serotonin Receptor Agonists; C015952:4-iodo-2,5-dimethoxyphenylisopropylamine; D013974:Thyroxine