Squamous cell carcinoma of the hypopharynx in a young woman with Fanconi's anemia.
Fanconi's anemia is a rare autosomal recessive disorder characterized by congenital malformation, bone marrow failure and genomic instability, with a predisposition to develop malignancies, especially the leukemias and upper aerodigestive tract tumors. Due to inherent characteristics to this syndrome, the treatment of such neoplasms is particularly difficult. In this paper we report the case of a 24-year-old woman with Fanconi's anemia who developed a squamous cell carcinoma of the hypopharynx; she had none of the traditional risk factors, such as smoking and alcohol abuse. We also briefly review the literature about this topic.
Lins e Horta
Henrique de
Hd
Hospital das Clínicas, Universidade Federal de Minas Gerais, Anchieta Belo Horizonte, 30310-370 MG. henriquelinshorta@yahoo.com.br
Guimarães
Fernando Fernandes
FF
Rocha
Luiz Otávio Savassi
LO
Guimarães
Roberto Eustáquio Santos
RE
Valadares
Eugênia Ribeiro
ER
D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000150:complications* / Q000175:diagnosis / Q000532:radiotherapy; D005199:Fanconi Anemia / Q000150:complications*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007013:Hypopharynx; D010610:Pharyngeal Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000532:radiotherapy