title: Hemorrhagic hereditary telangiectasia (Rendu-Osler disease) and infectious diseases: an underestimated association.
abstract: Among 353 patients with hereditary hemorrhagic telangiectasia retrospectively analyzed during the period 1985-2005, we identified 67 cases of severe infection that affected 48 patients (13.6%). Extracerebral infections accounted for 67% of all infections, and most involved Staphylococcus aureus and were associated with prolonged epistaxis. Cerebral infections accounted for 33% of all infections, were mainly due to multiple and anaerobic bacteria, and were associated with the presence of pulmonary arteriovenous malformations and a short duration of epistaxis.
authors.affiliation: Service de Génétique et Centre de Référence sur la Maladie de Rendu-Osler, Hôpital de l'Hôtel Dieu, Lyon, France. sophie.dupuis-girod@chu-lyon.fr
authors.forename: Sophie
authors.initials: S
authors.lastname: Dupuis-Girod
authors.forename: Sophie
authors.initials: S
authors.lastname: Giraud
authors.forename: Evelyne
authors.initials: E
authors.lastname: Decullier
authors.forename: Gaetan
authors.initials: G
authors.lastname: Lesca
authors.forename: Vincent
authors.initials: V
authors.lastname: Cottin
authors.forename: Frédéric
authors.initials: F
authors.lastname: Faure
authors.forename: Olivier
authors.initials: O
authors.lastname: Merrot
authors.forename: Jean-Christophe
authors.initials: JC
authors.lastname: Saurin
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Cordier
authors.forename: Henri
authors.initials: H
authors.lastname: Plauchu
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D015331:Cohort Studies; D003141:Communicable Diseases / Q000453:epidemiology* / Q000382:microbiology*; D015897:Comorbidity; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D018570:Risk Assessment; D012720:Severity of Illness Index; D017678:Sex Distribution; D016019:Survival Analysis; D013683:Telangiectasia, Hereditary Hemorrhagic / Q000175:diagnosis / Q000453:epidemiology*