Pt-catalyzed cyclization/1,2-migration for the synthesis of indolizines, pyrrolones, and indolizinones.
Indolizine, pyrrolone, and indolizinone heterocycles are easily accessed via the Pt(II)-catalyzed cycloisomerization or a tandem cyclization/1,2-migration of pyridine propargylic alcohols and derivatives. This method provides an efficient synthesis of highly functionalized heterocycles from readily available substrates. [reaction: see text]
Smith
Cameron R
CR
Department of Chemistry, University of California, Berkeley, CA 94720, USA.
Bunnelle
Eric M
EM
Rhodes
Allison J
AJ
Sarpong
Richmond
R
D000480:Alkynes / Q000737:chemistry; D002384:Catalysis; D003500:Cyclization; D006571:Heterocyclic Compounds / Q000138:chemical synthesis*; D007212:Indolizines / Q000138:chemical synthesis*; D007536:Isomerism; D008956:Models, Chemical; D010984:Platinum / Q000737:chemistry*; D020005:Propanols / Q000737:chemistry; D011725:Pyridines / Q000737:chemistry; D011758:Pyrroles / Q000138:chemical synthesis*
D000480:Alkynes; D006571:Heterocyclic Compounds; D007212:Indolizines; D020005:Propanols; D011725:Pyridines; D011758:Pyrroles; D010984:Platinum; C028255:propargyl alcohol; C023666:pyridine