title: Use of the collagen gel droplet embedded drug sensitivity test to determine drug sensitivity against ovarian mature cystic teratoma with malignant transformation to adenocarcinoma: a case report.
abstract: BACKGROUND
  The collagen gel droplet embedded drug sensitivity test (CD-DST) is a new anticancer drug sensitivity test that only requires a small number of cells. We report the use of this test in the choice of adjuvant chemotherapy for treatment of a rare case of ovarian cancer involving malignant transformation of ovarian mature cystic teratoma.
  
  
  METHODS
  The patient was a 70-year-old female with an ovarian tumor, pleural effusion, carcinomatous ascites and a chest wall tumor. The histopathological diagnosis was adenocarcinoma, mature cystic teratoma with malignant transformation, stage IV. Paclitaxel/carboplatin therapy was selected as adjuvant chemotherapy based on CD-DST results. Upon completion of 6 courses, no increases in carcinomatous ascites or recurrent lesions were evident, and the chest wall tumor had disappeared completely.
  
  
  CONCLUSIONS
  The CD-DST may be particularly useful for selecting preoperative chemotherapeutic drugs for patients with ovarian cancer in which the histological type of the primary tumor is unknown.
authors.affiliation: Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan. y_gami@msc.biglobe.ne.jp
authors.forename: Wataru
authors.initials: W
authors.lastname: Yamagami
authors.forename: Kouji
authors.initials: K
authors.lastname: Banno
authors.forename: Makiko
authors.initials: M
authors.lastname: Kawaguchi
authors.forename: Megumi
authors.initials: M
authors.lastname: Yanokura
authors.forename: Yoshiko
authors.initials: Y
authors.lastname: Kuwabara
authors.forename: Nobumaru
authors.initials: N
authors.lastname: Hirao
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Susumu
authors.forename: Katsumi
authors.initials: K
authors.lastname: Tsukazaki
authors.forename: Daisuke
authors.initials: D
authors.lastname: Aoki
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000473:pathology; D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols; D016190:Carboplatin / Q000008:administration & dosage; D024042:Collagen Type I; D004354:Drug Screening Assays, Antitumor; D005260:Female; D005782:Gels; D006801:Humans; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000473:pathology; D017239:Paclitaxel / Q000008:administration & dosage; D016066:Pleural Effusion, Malignant; D013724:Teratoma / Q000188:drug therapy* / Q000473:pathology
chemical_list: D000970:Antineoplastic Agents; D024042:Collagen Type I; D005782:Gels; D016190:Carboplatin; D017239:Paclitaxel