title: Management of dofetilide overdose in a patient with known cocaine abuse.
abstract: Dofetilide, a class III antiarrhythmic agent, is prescribed for conversion to and maintenance of normal sinus rhythm in patients with persistent atrial fibrillation or atrial flutter. Most antiarrhythmics have significant toxicities such as torsade de pointes, and patients should be closely monitored while receiving antiarrhythmic therapy. However, we know of no reports concerning management of intentional overdose of dofetilide that have been published. We report the case of a 33-year-old man who was treated for ingestion of approximately 5 mg of dofetilide as a suicide attempt. In addition, he had a known history of cocaine abuse. He came to the emergency department approximately 45 minutes after the ingestion; examination revealed a QTc interval of approximately 570 msec. He was treated with activated charcoal and sorbitol by nasogastric tube and received aggressive supplementation with potassium and magnesium. The patient was monitored by telemetry for several days and responded well. Cardiac toxicity is the utmost concern when treating dofetilide overdose. The mainstay of treatment focuses on supportive care and prevention of drug absorption. Ventricular dysrhythmias or torsade de pointes should be treated according to advanced cardiac life support guidelines.
authors.affiliation: Department of Pharmacy, Duke University Health System, Durham, North Carolina 27710, USA.
authors.forename: Kristen Bova
authors.initials: KB
authors.lastname: Campbell
authors.forename: Jennifer D
authors.initials: JD
authors.lastname: Mando
authors.forename: Alice L
authors.initials: AL
authors.lastname: Gray
authors.forename: Eric
authors.initials: E
authors.lastname: Robinson
mesh_terms: D000328:Adult; D000889:Anti-Arrhythmia Agents / Q000633:toxicity*; D002606:Charcoal / Q000627:therapeutic use; D019970:Cocaine-Related Disorders; D016903:Drug Monitoring; D062787:Drug Overdose / Q000188:drug therapy*; D004636:Emergency Service, Hospital; D004638:Emergency Treatment / Q000379:methods*; D006801:Humans; D008297:Male; D010627:Phenethylamines / Q000633:toxicity*; D013012:Sorbitol / Q000627:therapeutic use; D013406:Suicide, Attempted; D013449:Sulfonamides / Q000633:toxicity*
chemical_list: D000889:Anti-Arrhythmia Agents; D010627:Phenethylamines; D013449:Sulfonamides; D002606:Charcoal; D013012:Sorbitol; C063533:dofetilide