New aspect of immunosuppressive treatment in liver transplantation. How could you induce tolerance in liver transplantation?
New immunosuppressive strategies have improved short- and long-term graft survival. The current aim is to decrease the intensity of the immunosuppressive regimen, in an attempt to limit side effects and the direct toxicity of calcineurin inhibitor (CNI) for kidney function. We describe here current experience in liver and liver-kidney transplantation, the mechanism of tolerance and the immunosuppressive strategy used in liver transplantation.
Beaudreuil
Severine
S
Department of Nephrology, IFRNT University Hospital of Kremlin-Bicetre, 78 avenue du General Leclerc, 94275 Le Kremlin-Bicetre cedex, France.
Samuel
Didier
D
Rouas-Freiss
Nathalie
N
Durrbach
Antoine
A
D006084:Graft Rejection / Q000175:diagnosis / Q000517:prevention & control*; D006801:Humans; D007165:Immunosuppression Therapy / Q000379:methods*; D007166:Immunosuppressive Agents / Q000494:pharmacology; D016031:Liver Transplantation / Q000276:immunology*; D015166:Monitoring, Immunologic; D023001:Transplantation Tolerance
D007166:Immunosuppressive Agents