title: Age comparison of treatment adherence with antipsychotic medications among individuals with bipolar disorder.
abstract: BACKGROUND
  Few studies have evaluated medication adherence among older vs younger individuals with bipolar disorder (BPD). We compared adherence with antipsychotic medication among older (age 60 and older) and younger individuals using a large case registry (n = 73,964).
  
  
  METHODS
  Adherence was evaluated using the medication possession ratio (MPR) for patients receiving antipsychotic medication.
  
  
  RESULTS
  Twenty six thousand five hundred and thirty younger individuals (mean age 46.9) and 6,461 older individuals (mean age 69.2) were prescribed antipsychotic medication. Among older individuals, 61.0% (n = 3,350) were fully adherent, while 19.0% (n = 1,043) were partially adherent and 20.0% (n = 1,098) were non-adherent. Among younger individuals, 49.5% (n = 10,644) were fully adherent, while 21.8% (n = 4,680) were partially adherent, and 28.7% (n = 6,170) were non-adherent. As with younger patients, comorbid substance abuse and homelessness predicted non-adherence among older patients with BPD.
  
  
  CONCLUSIONS
  Older individuals with BPD were more adherent with antipsychotic medications compared to younger individuals. However, a substantial proportion (approximately 39%) of older patients with BPD still have difficulties with adherence.
authors.affiliation: Psychiatry and Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, OH, USA. martha.sajatovic@uhhs.com
authors.forename: Martha
authors.initials: M
authors.lastname: Sajatovic
authors.forename: Frederic C
authors.initials: FC
authors.lastname: Blow
authors.forename: Helen C
authors.initials: HC
authors.lastname: Kales
authors.forename: Marcia
authors.initials: M
authors.lastname: Valenstein
authors.forename: Dara
authors.initials: D
authors.lastname: Ganoczy
authors.forename: Rosalinda V
authors.initials: RV
authors.lastname: Ignacio
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D001714:Bipolar Disorder / Q000188:drug therapy* / Q000209:etiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010349:Patient Compliance / Q000706:statistics & numerical data*
chemical_list: D014150:Antipsychotic Agents