title: Recent developments in superporous hydrogels.
abstract: Superporous hydrogels (SPHs) were originally developed as a novel drug delivery system to retain drugs in the gastric medium. These systems should instantly swell in the stomach and maintain their integrity in the harsh stomach environment, while releasing the pharmaceutical active ingredient. For years, the synthetic features and properties of these SPH materials have been modified and improved to meet the requirements for gastric retention applications. Furthermore, an instant swelling hydrogel has also shown potential application for peroral intestinal peptide and protein absorption. This review discusses the formulation, characterization, properties and applications of these polymers.
authors.affiliation: Solid Dose Research and Development, Kos Pharmaceuticals, Inc., 2 Oakwood Boulevard, Hollywood, FL 33020, USA. homidian@kospharm.com
authors.forename: Hossein
authors.initials: H
authors.lastname: Omidian
authors.forename: Kinam
authors.initials: K
authors.lastname: Park
authors.forename: Jose G
authors.initials: JG
authors.lastname: Rocca
mesh_terms: D000818:Animals; D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems; D020100:Hydrogels / Q000737:chemistry*; D010316:Particle Size; D016062:Porosity
chemical_list: D003692:Delayed-Action Preparations; D004337:Drug Carriers; D020100:Hydrogels