title: Health-related quality of life following hematopoietic stem cell transplant during childhood.
abstract: The purpose of this study is to examine the self-reported and parent-reported health-related quality of life (HRQoL) of children (age<19 years) who received a hematopoietic (bone marrow, cord blood, or peripheral blood) stem cell transplant (SCT) at the University of Nebraska Medical Center (UNMC). A total of 35 families participated: 31 SCT recipients, 35 mothers, and 28 fathers. Mean scores were 73.6 child, 71.2 mothers, and 76.2 fathers (range of 0-100, with high scores indicating better HRQoL). No significant overall HRQoL difference between parent and child were reported. Mothers reported significantly lower physical functioning (F2,23=3.509, P=.041) compared to child (P=.041) and fathers (P=.025). Older age at time of transplant was associated with higher procedural anxiety according to child (r=.498, P=.005) and mothers (r=.466, P=.008). Older age at time of transplant was associated with less worry according to fathers (r=-.589, P=.002). Overall, SCT recipients and their parents report moderately high HRQoL.
authors.affiliation: Nebraska Medical Center, Omaha, NE 68198-7625, USA. slnuss@nebraskamed.com
authors.forename: Suzanne L
authors.initials: SL
authors.lastname: Nuss
authors.forename: Margaret E
authors.initials: ME
authors.lastname: Wilson
mesh_terms: D000293:Adolescent; D000741:Anemia, Aplastic / Q000628:therapy; D001007:Anxiety / Q000209:etiology / Q000523:psychology; D001294:Attitude to Health; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D005260:Female; D006304:Health Status; D018380:Hematopoietic Stem Cell Transplantation / Q000523:psychology*; D006801:Humans; D007223:Infant; D008297:Male; D009329:Nebraska; D009369:Neoplasms / Q000628:therapy; D015404:Nursing Methodology Research; D010290:Parents / Q000523:psychology*; D010865:Pilot Projects; D002666:Psychology, Child; D011788:Quality of Life / Q000523:psychology*; D011795:Surveys and Questionnaires; D017741:Survivors / Q000523:psychology*; D013789:Thalassemia / Q000628:therapy; D014923:Wiskott-Aldrich Syndrome / Q000628:therapy