title: Chemical components from Gentiana aristata.
abstract: Two new, highly oxygenated ursane-type triterpenoids with an epidioxy function, compounds 1 and 2, as well as a new stanside-derived iridoid, compound 10, were isolated from the EtOH extract of Gentiana aristata (whole plant), together with 14 known constituents. The structures of the new compounds were established on the basis of detailed spectroscopic investigations, such as 1D- and 2D-NMR spectroscopy, as well as by means of HR-MS. Compounds 3 and 5-9 were screened in vitro for their cytotoxicities against human promyelocytic leukemia (HL-60), human ovarian (HO-8910), and human lung epithelia (A-549) cancer cells.
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, PR China.
authors.forename: Quan-Xiang
authors.initials: QX
authors.lastname: Wu
authors.forename: Xia
authors.initials: X
authors.lastname: Liu
authors.forename: Yan-Ping
authors.initials: YP
authors.lastname: Shi
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor; D030012:Gentiana / Q000737:chemistry*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D014315:Triterpenes / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D014315:Triterpenes