The use of i. v. bisphosphonate in pregnancy-associated osteoporosis--case study.
OBJECTIVE
Diagnosis of pregnancy-associated osteoporosis is often delayed and therapeutic interventions insufficient.


METHODS
A 28-year-old patient (BMI=18.6) with no additional risks for osteoporosis experienced acute lumbosacral pain two months postpartum, while lactating. After conservative therapy, thoracic and lumbar spine were X-rayed: severe pregnancy-associated osteoporosis with vertebral fractures was diagnosed. 2-year treatment with i. v. bisphosphonate ibandronate was initiated (2 mg every 3 months) and calcium and vitamin D supplementation.


RESULTS
Rapid improvement was observed. Conclusion: In cases with multiple fractures i. v. bisphosphonate leads to substantial decrease of symptoms and further fractures and significant increase of bone mass density (BMD).


CONCLUSIONS
In severe cases of pregnancy-associated osteoporosis with multiple fractures i. v. biphosphonate therapy leads to a decrease of symptoms and fracture risk and an increase of bone mass density (BMD).
Hellmeyer
L
L
Department of Obstetrics and Perinatal Medicine, Philipps-University of Marburg, Marburg, Germany. hellmeye@med.uni-marburg.de
Kühnert
M
M
Ziller
V
V
Schmidt
S
S
Hadji
P
P
D000328:Adult; D015519:Bone Density; D050071:Bone Density Conservation Agents / Q000008:administration & dosage; D004164:Diphosphonates / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D010024:Osteoporosis / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000209:etiology*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy; D011859:Radiography
D050071:Bone Density Conservation Agents; D004164:Diphosphonates