title: The presence of insulin resistance and comparison of various insulin sensivity indices in women with androgenetic alopecia.
abstract: We aimed to identify the association of female androgenetic alopecia with insulin resistance and to evaluate various simple insulin sensitivity indices and beta cell function in women with androgenetic alopecia (AGA). A cross-sectional study was performed in 66 non-obese women (24-44 years old), 41 with AGA alone and 25 healthy individuals. Blood glucose, insulin, c-peptide levels, oral glucose tolerance test (OGTT); insulin sensitivity and beta cell function indices derived from a single blood sample and OGTT were determined and compared in the two groups. Women with AGA had impaired glucose tolerance (IGT) rates of 12.5%. In the control group IGT was 0%. Fasting glucose, c-peptide, insulin were higher in AGA group. When the indices were evaluated, Raynaud index, FIRI and HOMA-IR results found to be higher in the AGA group than in controls (p < 0.05, for all). Fasting insulin(-1), GIR, FIRI(-1), QUICKY index, ISI HOMA, HOMA-IS results were lower in AGAs than in controls (p < 0.05, for all). Our study showed that women with AGA alone were more insulin resistant than healthy subjects. We suggest that beta cell function and insulin sensitivity indices are useful methods for measuring insulin resistance in AGAs, and HOMA-IR is a good predictor of insulin resistance. We propose that OGTT should be applied in women with AGA.
authors.affiliation: Department of Dermatology, Sisli Etfal Research and Training Hospital, Istanbul, Turkey. tre@ttnet.net
authors.forename: Tugba Rezan
authors.initials: TR
authors.lastname: Ekmekci
authors.forename: Sema
authors.initials: S
authors.lastname: Ucak
authors.forename: Okcan
authors.initials: O
authors.lastname: Basat
authors.forename: Adem
authors.initials: A
authors.lastname: Koslu
authors.forename: Yuksel
authors.initials: Y
authors.lastname: Altuntas
mesh_terms: D000328:Adult; D000505:Alopecia / Q000378:metabolism*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007333:Insulin Resistance