title: Oral manifestations of Wegener's granulomatosis: a report of three cases and a literature review.
abstract: BACKGROUND
  Hyperplastic granular gingivitis or "strawberry gingivitis" is a rare manifestation of Wegener's granulomatosis (WG), but it is nearly pathognomonic for this multisystem autoimmune vasculitis. The dentist may be the first health care professional to see patients with symptoms and findings of this condition. Early diagnosis and treatment is the most important factor in the management of this potentially fatal disease.
  
  
  METHODS
  The authors present three case reports that demonstrate the disease spectrum and conducted a literature review focused on current understanding of this disease.
  
  
  RESULTS
  The first patient had only the classic gingival manifestations of the disease. The second patient had simultaneous typical gingival lesions, as well as dermatologic findings. The third patient had an atypical oral presentation of aphthous ulcers and erythematous gingiva, as well as respiratory and genital involvement. Reaching a definitive diagnosis sometimes is challenging owing to the subtle onset of the disease and variable clinical and laboratory findings.
  
  
  CONCLUSIONS
  Clinicians should be familiar with the broad variety of oral and systemic components of WG, as well as strategies to facilitate prompt disease recognition and to provide continued oral health care to these medically complex patients.
authors.affiliation: Department of Oral and Maxillofacial Surgery and Diagnostic Sciences, University of Florida, College of Dentistry, Gainesville, FL 32610, USA. cstewart@dental.ufl.edu
authors.forename: Carol
authors.initials: C
authors.lastname: Stewart
authors.forename: Donald
authors.initials: D
authors.lastname: Cohen
authors.forename: Indraneel
authors.initials: I
authors.lastname: Bhattacharyya
authors.forename: Lawrence
authors.initials: L
authors.lastname: Scheitler
authors.forename: Steven
authors.initials: S
authors.lastname: Riley
authors.forename: Kenneth
authors.initials: K
authors.lastname: Calamia
authors.forename: Cesar
authors.initials: C
authors.lastname: Migliorati
authors.forename: Ronald
authors.initials: R
authors.lastname: Baughman
authors.forename: Perry
authors.initials: P
authors.lastname: Langford
authors.forename: Joseph
authors.initials: J
authors.lastname: Katz
mesh_terms: D000328:Adult; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000032:analysis; D003937:Diagnosis, Differential; D005260:Female; D005885:Gingival Hyperplasia / Q000188:drug therapy / Q000209:etiology*; D014890:Granulomatosis with Polyangiitis / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D019226:Oral Ulcer / Q000188:drug therapy / Q000209:etiology*; D012852:Sinusitis / Q000209:etiology
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic