title: The study of inhibiting systematic inflammatory response syndrome by applying xenogenic (porcine) acellular dermal matrix on second-degree burns.
abstract: OBJECTIVE
  To investigate the influence of xenogenic (porcine) acellular dermal matrix on the systematic inflammatory reaction syndrome (SIRS), and the reaction of burn patients to tissue damage upon application to second-degree burn wounds.
  
  
  METHODS
  Seventy-two cases of patients with acute second-degree burns were enrolled in the study. According to the total burn surface area (TBSA) and the treatment methods, we randomly divided the patients into four groups. Group A (treatment group): patients with less than 30% TBSA covered with xenogenic acellular dermal matrix. Group B (control group): patients with less than 30% TBSA covered with betadine ointment gauzes. Group C (treatment group): patients with more than 30% TBSA covered with porcine acellular dermal matrix. Group D (control group): patients with more than 30% TBSA covered with betadine ointment gauzes. Serum level of C-reactive protein (CRP) was measured by single radial immunodiffusion method on 1, 4, 7 and 14 days postburn.
  
  
  RESULTS
  The serum level of CRP in group A was significantly less than that of in group B (P<0.05) on days 4, 7 and 14. The serum level of CRP in group C increased slowly, descended quickly and was significantly less than that of in group D on days 4, 7 and 14.
  
  
  CONCLUSIONS
  The application of xenogenic (porcine) acellular dermal matrix on second-degree burn wound can decrease serum level of CRP of the patients, which may play an important role in reducing SIRS and sepsis incidence.
authors.affiliation: Department of Plastic and Burn Surgery, The First People's Hospital of Foshan, Foshan 528000, China.
authors.forename: Xiangsheng
authors.initials: X
authors.lastname: Feng
authors.forename: Rui
authors.initials: R
authors.lastname: Shen
authors.forename: Jiaju
authors.initials: J
authors.lastname: Tan
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Chen
authors.forename: Yingen
authors.initials: Y
authors.lastname: Pan
authors.forename: Shubin
authors.initials: S
authors.lastname: Ruan
authors.forename: Fenggang
authors.initials: F
authors.lastname: Zhang
authors.forename: Zepeng
authors.initials: Z
authors.lastname: Lin
authors.forename: Yinghong
authors.initials: Y
authors.lastname: Zeng
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Wang
authors.forename: Yan
authors.initials: Y
authors.lastname: Lin
authors.forename: Qiuhe
authors.initials: Q
authors.lastname: Wu
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D001684:Biological Dressings; D002056:Burns / Q000097:blood / Q000628:therapy*; D002097:C-Reactive Protein / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D020405:Dermis / Q000637:transplantation*; D006801:Humans; D007223:Infant; D008875:Middle Aged; D017768:Skin, Artificial; D013552:Swine; D018746:Systemic Inflammatory Response Syndrome / Q000097:blood / Q000517:prevention & control*; D014183:Transplantation, Heterologous
chemical_list: D002097:C-Reactive Protein