The paradox of natural products as pharmaceuticals. Experimental evidences of a mango stem bark extract.
Recent findings regarding basic, pre-clinical and clinical studies on a mango stem bark extract (MSBE) developed in Cuba (Vimang) on an industrial scale are summarized. Ethnomedical studies, extract reproducibility, biological effects and clinical evaluations in terms of patient quality of life are described as experimental evidences to support the statement that natural products, even being a mixture of compounds, could be as effective as "monoceuticals" for medical uses. Discussion about the use of "monoceuticals" versus "natureceuticals" in health care and medicine is based on effectiveness and availability, taking Vimang as an example of a natural product with supported scientific evidence to be used as antioxidant, analgesic, anti-inflammatory and immunomodulator.
Núñez-Sellés
Alberto J
AJ
Center of Pharmaceutical Chemistry, 21 Ave. & 200 St., Atabey, Apdo. 16042, CP 11600 Havana, Cuba. alberto.nunez@cqf.sld.cu
Delgado-Hernández
René
R
Garrido-Garrido
Gabino
G
García-Rivera
Dagmar
D
Guevara-García
Mariela
M
Pardo-Andreu
Gilberto L
GL
D000700:Analgesics / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology*; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D004304:Dosage Forms / Q000592:standards; D004353:Drug Evaluation, Preclinical; D006801:Humans; D007155:Immunologic Factors / Q000737:chemistry / Q000494:pharmacology*; D031022:Mangifera; D024301:Plant Bark; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D011786:Quality Control; D015203:Reproducibility of Results; D013678:Technology, Pharmaceutical / Q000379:methods; D016896:Treatment Outcome
D000700:Analgesics; D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D004304:Dosage Forms; D007155:Immunologic Factors; C501277:Mangifera indica extract; D010936:Plant Extracts