Dose selection in stereotactic radiosurgery.
Selecting optimal doses for radiosurgery requires a thorough consideration of existing dose-response data for radiation injury of brain and surrounding structures and of the doseresponse for the desired endpoint (tumor control, obliteration of a vascular malformation, relief of trigeminal neuralgia, etc.). This paper reviews the radiobiological and physics principles that should be considered in dose selection as well as information from retrospective and prospective clinical investigations of radiosurgery.
Flickinger
John C
JC
Department of Radiation Oncology, University of Pittsburgh School of Medicine, Pittsburgh, Pa., USA.
Kondziolka
Douglas
D
Niranjan
Ajay
A
Lunsford
L Dade
LD
D001932:Brain Neoplasms / Q000532:radiotherapy / Q000556:secondary / Q000601:surgery*; D005909:Glioblastoma / Q000601:surgery; D006801:Humans; D011832:Radiation Injuries / Q000517:prevention & control; D016634:Radiosurgery / Q000009:adverse effects / Q000379:methods*; D011879:Radiotherapy Dosage; D018570:Risk Assessment; D017211:Treatment Failure