title: Reverse gyrase: an insight into the role of DNA-topoisomerases.
abstract: Reverse gyrase was discovered more than twenty years ago. Recent biochemical and structural results have greatly enhanced our understanding of their positive supercoiling mechanism. In addition to new biochemical properties, a fine tuning of reverse gyrase regulation in response to DNA damaging agents has been recently described. These data give us a new insight in the cellular role of reverse gyrase. Moreover, it has been proposed that reverse gyrase has been implicated in genome stability.
authors.affiliation: Equipe Virologie Moléculaire et Microbiologie, Laboratoire de Génétique et de Biologie Cellulaire, CNRS UMR 8159, Université de Versailles St-Quentin-en-Yvelines, Bâtiment Buffon, 78 035 Versailles, France. marc.nadal@igmors.u-psud.fr
authors.forename: Marc
authors.initials: M
authors.lastname: Nadal
mesh_terms: D004249:DNA Damage; D026942:DNA Topoisomerases / Q000235:genetics / Q000378:metabolism*; D004264:DNA Topoisomerases, Type I / Q000235:genetics / Q000378:metabolism*; D004278:DNA, Superhelical / Q000378:metabolism; D016678:Genome; D007700:Kinetics
chemical_list: D004278:DNA, Superhelical; D026942:DNA Topoisomerases; C041813:DNA reverse gyrase; D004264:DNA Topoisomerases, Type I