title: Polyene antibiotics from Streptomyces mediocidicus.
abstract: Three polyene antibiotics, mediomycins A (1), B (2), and clethramycin (3), were isolated from Streptomyces mediocidicus ATCC23936. Their structures were elucidated through extensive NMR study coupled with chemical reactions and MS/MS fragmentation analysis. All three compounds are linear polyenes consisting of a conjugated oxo-triene group and a hexaene moiety. Compounds 1 and 2 are new polyenes. All three compounds demonstrated a broad spectrum of antifungal activity in vitro.
authors.affiliation: Chemical and Pharmaceutical Development, Wyeth Research, 401 N. Middletown Road, Pearl River, New York 10965, USA. caip@wyeth.com
authors.forename: Ping
authors.initials: P
authors.lastname: Cai
authors.forename: Fangming
authors.initials: F
authors.lastname: Kong
authors.forename: Pamela
authors.initials: P
authors.lastname: Fink
authors.forename: Mark E
authors.initials: ME
authors.lastname: Ruppen
authors.forename: R Thomas
authors.initials: RT
authors.lastname: Williamson
authors.forename: Tabei
authors.initials: T
authors.lastname: Keiko
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D005231:Fatty Acids, Unsaturated / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D005658:Fungi / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011090:Polyenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D013302:Streptomyces / Q000737:chemistry*; D013463:Sulfuric Acid Esters / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000935:Antifungal Agents; D005231:Fatty Acids, Unsaturated; D011090:Polyenes; D013463:Sulfuric Acid Esters; C478490:clethramycin; C518552:mediomycin A; C518553:mediomycin B