title: Primary cardiac plasmablastic (diffuse large B-cell) lymphoma mimicking left ventricular aneurysm with mural thrombus.
abstract: Primary cardiac lymphoma is rare and is usually of the non-Hodgkin type. By definition, it involves only the heart and the pericardium, with no evidence of extracardiac disease. Primary cardiac lymphoma accounts for 1% of primary cardiac tumors and 0.5% of extranodal lymphomas [Gowda RM, Kahn RA. Clinical perspectives of primary cardiac lymphoma. Angiology 2003;54(5):599-604]. On the other hand, secondary cardiac involvement can occur in approximately 20% of patients with disseminated extracardiac lymphoma [Gowda RM, Kahn RA. Clinical perspectives of primary cardiac lymphoma. Angiology 2003;54(5):599-604]. The majority of primary cardiac lymphomas are diffuse large B-cell lymphomas with centroblastic or immunoblastic cytologic features. Herein, we describe an exceptional case of a primary cardiac plasmablastic variant of diffuse large B-cell lymphoma (Epstein-Barr virus-positive) presenting in an immunocompetent host with chest pain that mimicked a left ventricular apical thrombus.
authors.affiliation: Division of Anatomic Pathology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA. miller.dylan@mayo.edu
authors.forename: Dylan V
authors.initials: DV
authors.lastname: Miller
authors.forename: Farouk
authors.initials: F
authors.lastname: Mookadam
authors.forename: Martina
authors.initials: M
authors.lastname: Mookadam
authors.forename: William D
authors.initials: WD
authors.lastname: Edwards
authors.forename: William R
authors.initials: WR
authors.lastname: Macon
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism; D002037:Bundle-Branch Block / Q000209:etiology / Q000473:pathology; D051925:CD79 Antigens / Q000378:metabolism; D002637:Chest Pain / Q000175:diagnosis / Q000209:etiology; D003323:Coronary Aneurysm / Q000150:complications / Q000175:diagnosis*; D004279:DNA, Viral / Q000032:analysis; D003937:Diagnosis, Differential; D004562:Electrocardiography; D020031:Epstein-Barr Virus Infections / Q000150:complications / Q000378:metabolism / Q000473:pathology; D017809:Fatal Outcome; D006352:Heart Ventricles / Q000378:metabolism / Q000473:pathology; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000302:isolation & purification; D006801:Humans; D017403:In Situ Hybridization; D050835:Interferon Regulatory Factors / Q000378:metabolism; D016393:Lymphoma, B-Cell / Q000378:metabolism / Q000473:pathology* / Q000821:virology; D016403:Lymphoma, Large B-Cell, Diffuse / Q000378:metabolism / Q000473:pathology* / Q000821:virology; D008297:Male; D010496:Pericardium / Q000378:metabolism / Q000473:pathology; D013927:Thrombosis / Q000150:complications / Q000175:diagnosis*; D000099218:Interferon Regulatory Factor-4
chemical_list: D014408:Biomarkers, Tumor; D051925:CD79 Antigens; D004279:DNA, Viral; D050835:Interferon Regulatory Factors; D000099218:Interferon Regulatory Factor-4