title: [Treatment and prognostic analysis of 92 cases with advanced mobile tongue squamous cell carcinoma].
abstract: OBJECTIVE
  To compare the results of different treatment modalities for the advanced tongue squamous cell carcinoma and investigate the factors that influence its prognosis.
  
  
  METHODS
  Ninety-two patients with advanced tongue squamous cell carcinoma without distant metastasis, treated in our hospital from Jan. 1990 to Dec. 1999 were retrospectively reviewed. Survival rate was estimated by Kaplan-Meier method, and multivariate analysis was performed by the Cox Proportional hazard model.
  
  
  RESULTS
  The overall 3-year and 5-year survival rates were 52.40% and 37.23% respectively. There was a significant difference in the overall between the two groups survival rate (chemotherapy only and radiotherapy after induced chemotherapy) and the three groups (operation only, operation after induced chemotherapy, radiotherapy after operation) cTNM stage, operation for the primary lesion and local recurrence were the independent factors that influenced the prognosis.
  
  
  CONCLUSIONS
  Risk factors that independently influence the survival of patients with advanced tongue squamous cell carcinoma were the local recurrence, cTNM and receiving operation or not for the primary lesion. Operation only or comprehensive therapy including operation could give a better prognosis, but the results of chemotherapy only or radiotherapy after chemotherapy were poor.
authors.affiliation: Departmemt of Head and Neck Surgery, The Third Affiliated Hospital of Kunming Medical College, Kunming 650118, China. scz007@126.com
authors.forename: Chuan-zheng
authors.initials: CZ
authors.lastname: Sun
authors.forename: Fu-jin
authors.initials: FJ
authors.lastname: Chen
authors.forename: Zong-yuan
authors.initials: ZY
authors.lastname: Zeng
authors.forename: Li-fei
authors.initials: LF
authors.lastname: Deng
authors.forename: An-kui
authors.initials: AK
authors.lastname: Yang
authors.forename: Yan-feng
authors.initials: YF
authors.lastname: Chen
mesh_terms: D000328:Adult; D000368:Aged; D003131:Combined Modality Therapy / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D018307:Neoplasms, Squamous Cell / Q000473:pathology / Q000628:therapy*; D011379:Prognosis; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D014062:Tongue Neoplasms / Q000473:pathology / Q000628:therapy*