Serum anticholinergic activity and motor performance in elderly persons.
BACKGROUND
Medications prescribed to elderly persons often have an anticholinergic effect, as do many commonly used over-the-counter drugs. Anticholinergic medications are known to produce psychomotor slowing, especially in older persons.


METHODS
The present study examined whether the cumulative anticholinergic load present in the serum of community volunteers was associated with decrements on tests of psychomotor performance (gait speed and simple manual response time) known to predict falls in elderly persons.


RESULTS
Serum anticholinergic activity (SAA) was relatively low in this group; however, an elevated SAA was associated with a significant slowing in both gait speed and simple response time.


CONCLUSIONS
Cumulative anticholinergic burden may be one of the factors contributing to an increased risk of falls in the older population.
Nebes
Robert D
RD
Department of Psychiatry, University of Pittsburgh Medical Center, Pennsylvania, USA. nebesrd@upmc.edu
Pollock
Bruce G
BG
Halligan
Edythe M
EM
Kirshner
Margaret A
MA
Houck
Patricia R
PR
D000368:Aged; D000375:Aging / Q000097:blood* / Q000187:drug effects; D018680:Cholinergic Antagonists / Q000009:adverse effects / Q000493:pharmacokinetics*; D005260:Female; D005500:Follow-Up Studies; D005684:Gait / Q000187:drug effects / Q000502:physiology; D006801:Humans; D008297:Male; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology*; D018727:Muscarinic Antagonists / Q000009:adverse effects / Q000493:pharmacokinetics; D011596:Psychomotor Disorders / Q000097:blood* / Q000139:chemically induced / Q000503:physiopathology; D012307:Risk Factors; D007319:Sleep Initiation and Maintenance Disorders / Q000097:blood / Q000188:drug therapy / Q000503:physiopathology
D018680:Cholinergic Antagonists; D018727:Muscarinic Antagonists