Histiocytoid breast cancer: an uncommon histologic variant of lobular carcinoma.
We present a case of histiocytoid breast cancer (HBC), which is a rare variant of breast carcinoma. The patient underwent an excisional biopsy for a palpable mass in her right breast. The neoplastic cells exhibited pronounced histiocytoid appearance. Immunohistochemical and histochemical studies were performed and tumor cells were positive for PAS, keratin PAN-CK, EMA, progesterone (PgR) and estrogen receptors (ER), while S-100 protein, CD68, CEA, and c-erbB2 were negative. Differential diagnosis issues and immunohistochemical data are emphasized and the literature is reviewed.
Eroğlu
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Department of General Surgery and Surgical Oncology, Numune State Hospital, Konya, Turkey. aydaneroglu@hotmail.com
Sari
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D001943:Breast Neoplasms / Q000473:pathology*; D018275:Carcinoma, Lobular / Q000473:pathology*; D005260:Female; D006644:Histiocytes / Q000473:pathology*; D006801:Humans; D008875:Middle Aged