title: Predicting outcome of pulmonary valve replacement in adult tetralogy of Fallot patients.
abstract: BACKGROUND
  Predicting changes in right ventricular (RV) size and function after pulmonary valve replacement (PVR) is important for timely reintervention in adult tetralogy of Fallot patients.
  
  
  METHODS
  We analyzed the influence of pulmonary regurgitation severity and RV size and function before PVR on the outcome of RV size and function after PVR in 27 adult Fallot patients who had cardiac magnetic resonance imaging before and after PVR. RV dimensions were indexed for body surface area.
  
  
  RESULTS
  Pulmonary regurgitation (48% +/- 11% of RV stroke volume) was not related to RV dimensions and function before PVR. Moreover, severity of pulmonary regurgitation did not influence changes in RV dimensions after PVR. The indexed RV end-systolic volume before PVR (mean, 98 mL/m2; range, 52 to 235 mL/m2) best predicted the indexed RV end-systolic volume after PVR (mean, 59 mL/m2; range, 24 to 132 mL/m2, r = 0.78, p < 0.001) and the indexed RV end-diastolic volume after PVR (mean, 107 mL/m2; range, 70 to 170 mL/m2, r = 0.73, p < 0.001). Baseline RV ejection fraction corrected for valvular insufficiencies and shunting (21% +/- 7%) best predicted the RV ejection fraction after PVR (43% +/- 10%, r = 0.77, p < 0.001).
  
  
  CONCLUSIONS
  Timing of PVR should be based on indexed RV end-systolic volume and corrected RV ejection fraction rather than on severity of pulmonary regurgitation.
authors.affiliation: Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.
authors.forename: Ivo R
authors.initials: IR
authors.lastname: Henkens
authors.forename: Alexander
authors.initials: A
authors.lastname: van Straten
authors.forename: Martin J
authors.initials: MJ
authors.lastname: Schalij
authors.forename: Mark G
authors.initials: MG
authors.lastname: Hazekamp
authors.forename: Albert
authors.initials: A
authors.lastname: de Roos
authors.forename: Ernst E
authors.initials: EE
authors.lastname: van der Wall
authors.forename: Hubert W
authors.initials: HW
authors.lastname: Vliegen
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D011184:Postoperative Period; D011312:Pressure; D011379:Prognosis; D011664:Pulmonary Valve / Q000473:pathology / Q000637:transplantation*; D011665:Pulmonary Valve Insufficiency / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology / Q000601:surgery*; D013318:Stroke Volume; D013771:Tetralogy of Fallot / Q000150:complications*; D014184:Transplantation, Homologous; D016896:Treatment Outcome; D016278:Ventricular Function, Right