title: Three equine cases of mixed hepatoblastoma with teratoid features.
abstract: Hepatoblastoma was diagnosed in 3 Thoroughbreds at the University of Kentucky Livestock Disease Diagnostic Center (LDDC) since 1997. Case #1 involved a fetus with a well-demarcated, multilobulated, solitary mass that extended from the left liver lobe. Case #2 was observed in a neonate with a primary hepatic mass and multiple metastases in the skin, brain, meninges, and stylohyoid bone. Case #3 was a solitary hepatic mass incidentally discovered in a neonate at necropsy. Microscopically, the masses were similarly composed of sheets and cords of fetal and embryonal epithelial cells that frequently formed sinusoid-like structures. Intermixed with the neoplastic epithelial cells were variable amounts of hemorrhage, necrosis, osteoid, and bone. Immunohistochemically, the epithelial cells stained variably positive for alpha- fetoprotein, frequently positive for vimentin, and occasionally positive for cytokeratin. All 3 cases were diagnosed as mixed hepatoblastoma with teratoid features.
authors.affiliation: Liverstock Disease Diagnostic Center, University of Kentucky, PO Box 14125, Lexington, KY 40512, USA. alan.loynachan@uky.edu
authors.forename: A T
authors.initials: AT
authors.lastname: Loynachan
authors.forename: D C
authors.initials: DC
authors.lastname: Bolin
authors.forename: C B
authors.initials: CB
authors.lastname: Hong
authors.forename: K B
authors.initials: KB
authors.lastname: Poonacha
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D017809:Fatal Outcome; D005333:Fetus; D018197:Hepatoblastoma / Q000473:pathology / Q000662:veterinary*; D006734:Horse Diseases / Q000473:pathology*; D006736:Horses; D007150:Immunohistochemistry / Q000662:veterinary; D008113:Liver Neoplasms / Q000473:pathology / Q000662:veterinary*; D013724:Teratoma / Q000473:pathology / Q000662:veterinary*