Traffic jams: dynamic models for neurofilament accumulation in motor neuron disease.
The dynamics of axonal transport are often colloquially described using highway traffic as a model system. Examination of the physics of traffic patterns, with emphasis on traffic jams and accidents, provides unique and perhaps counterintuitive insight into the aberrant accumulation of neurofilaments that accompanies amyotrophic lateral sclerosis/motor neuron disease.
Shea
Thomas B
TB
Center for Cellular Neurobiology and Neurodegeneration Research, Department of Biological Sciences, University of Massachusetts Lowell, Lowell, MA 01854, USA. thomas_shea@uml.edu
Beaty
William J
WJ
D006801:Humans; D007382:Intermediate Filaments / Q000473:pathology*; D008954:Models, Biological; D016472:Motor Neuron Disease / Q000473:pathology*; D021381:Protein Transport / Q000502:physiology*