[The endocrinology of the critically ill].
Critical illness is characterized by one or more failing organs. Hormonal regulation of metabolism changes during the course of critical illness and is related to the severity of disease. Hormonal effects and inflammatory reactions are important and interrelated factors with respect to outcome. Recent large scale insulin infusion studies have demonstrated beneficial effects on both the immune response and coagulation systems. Future research will show whether further hormonal substitution can reveal similar results.
Gjedsted
Jakob
J
Arhus Universitetshospital, Arhus Sygehus, Intensiv Afsnit ITA. jakobgjedsted@dadlnet.dk
Larsen
Kim Michael
KM
Hansen
Troels Krarup
TK
D003422:Critical Care / Q000379:methods*; D016638:Critical Illness / Q000401:mortality / Q000628:therapy*; D005943:Gluconeogenesis; D006728:Hormones / Q000008:administration & dosage / Q000378:metabolism*; D006801:Humans; D007328:Insulin / Q000008:administration & dosage; D007333:Insulin Resistance; D009102:Multiple Organ Failure / Q000188:drug therapy / Q000378:metabolism / Q000401:mortality; D011379:Prognosis
D006728:Hormones; D007328:Insulin