Chemotherapy of leishmaniasis. Part V: Synthesis and in vitro bioevaluation of novel pyridinone derivatives.
Some novel 2-substituted pyridinone derivatives exemplified by 3 and 4 have been synthesized from 2-methyl-gamma-pyrone and screened towards in vitro antileishmanial activity profile. Some of the compounds such as 3a, 3b, 4i and 4j displayed good antileishmanial profile.
Pandey
Susmita
S
Division of Medicinal Chemistry, Central Drug Research Institute, Chatter Manzil, Lucknow 226001, Uttar Pradesh, India.
Suryawanshi
S N
SN
Nishi
Goyal
Neena
N
Gupta
Suman
S
D000981:Antiprotozoal Agents / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D006801:Humans; D007896:Leishmaniasis / Q000188:drug therapy*; D011728:Pyridones / Q000627:therapeutic use*
D000981:Antiprotozoal Agents; D011728:Pyridones