title: Secophnane-type alkaloids from Daphniphyllum oldhami.
abstract: Four new alkaloids, daphnioldhanins D-G (1-4, resp.), together with five known alkaloids, daphmacropodine (5), secodaphniphylline (6), deoxycalyciphylline B (7), deoxyisocalyciphylline B (8), and daphmanidin A (9), were isolated from the roots of Daphniphyllum oldhami. Their structures were elucidated on the basis of spectroscopic data and chemical methods. Compound 1 at 2.0 microM showed potent antioxidant activity against H(2)O(2)-induced impairment in PC12 cells.
authors.affiliation: The Key Laboratory of Chemistry for Natural Product of Guizhou Province and Chinese Academy of Sciences, Guiyang 550002, PR China.
authors.forename: Shu-Zhen
authors.initials: SZ
authors.lastname: Mu
authors.forename: Xian-Wen
authors.initials: XW
authors.lastname: Yang
authors.forename: Ying-Tong
authors.initials: YT
authors.lastname: Di
authors.forename: Hong-Ping
authors.initials: HP
authors.lastname: He
authors.forename: Ye
authors.initials: Y
authors.lastname: Wang
authors.forename: Yue-Hu
authors.initials: YH
authors.lastname: Wang
authors.forename: Ling
authors.initials: L
authors.lastname: Li
authors.forename: Xiao-Jiang
authors.initials: XJ
authors.lastname: Hao
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D016716:PC12 Cells; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats
chemical_list: D000470:Alkaloids; D000975:Antioxidants; D004365:Drugs, Chinese Herbal