title: [Expression of synaptophysin in experimental diffuse brain injury].
abstract: OBJECTIVE
  To investigate the changes in the expression_level of synaptophysin following diffuse brain injury (DBI) in rats and to correlate the changes of the synaptophysin expression_level with the post injury time interval.
  
  
  METHODS
  Wister rats were used as a DBI model induced by Marmarou method. The changes of synaptophysin immunoreactivity on coronal sections of the rats sampled at different post-injury time intervals were used as a marker. The densitometry of the synaptophysin immunoreactivity was documented by imaging technique and analyzed by SPSS software.
  
  
  RESULTS
  The expression level of synaptophysin in DBI rats showed dynamic changes following DBI as well as during the repairing period.
  
  
  CONCLUSIONS
  The changes of synaptophysin level may be used as a marker for estimation of the post injury time interval in DBI.
authors.affiliation: Department of Forensic Science, Medical College, Xi'an Jiaotong University, Xi'an 710061, China. xafansl@mail.xjtu.edu.cn
authors.forename: Shuan-liang
authors.initials: SL
authors.lastname: Fan
authors.forename: Ping
authors.initials: P
authors.lastname: Huang
authors.forename: Yan-feng
authors.initials: YF
authors.lastname: Liu
authors.forename: Pin
authors.initials: P
authors.lastname: Zhang
authors.forename: Zhen-yuan
authors.initials: ZY
authors.lastname: Wang
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism* / Q000473:pathology; D001930:Brain Injuries / Q000378:metabolism* / Q000473:pathology; D002540:Cerebral Cortex / Q000378:metabolism / Q000473:pathology; D020833:Diffuse Axonal Injury / Q000378:metabolism / Q000473:pathology; D004195:Disease Models, Animal; D007150:Immunohistochemistry; D020198:Intracranial Hemorrhage, Traumatic / Q000378:metabolism / Q000473:pathology; D009474:Neurons / Q000378:metabolism* / Q000473:pathology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013194:Staining and Labeling; D013569:Synapses / Q000378:metabolism / Q000473:pathology; D016708:Synaptophysin / Q000378:metabolism*; D013997:Time Factors
chemical_list: D016708:Synaptophysin