title: Plasmalogens in human serum positively correlate with high- density lipoprotein and decrease with aging.
abstract: OBJECTIVE
  The objective of the present study was to propose plasmalogens as a beneficial factor in human plasma by showing a highly positive correlation with high-density lipoprotein (HDL) and a significant reduction with aging.
  
  
  METHODS
  For 148 elderly subjects suspected of coronary artery disease (CAD), clinical characteristics such as coronary stenosis, hyperlipidemia, abnormal glucose tolerance, and hypertension were investigated, and serum biochemical markers including plasmalogens were determined.
  
  
  RESULTS
  Serum plasmalogens levels tended to fall in significant coronary stenosis and abnormal glucose tolerance. Correlative analyses among serum biochemical markers revealed that plasmalogens positively correlate with HDL-related values, particularly apolipoprotein A-I (apo A-I), and that the molar ratio of choline plasmalogen (ChoPlas) to ethanolamine plasmalogen (EtnPlas) correlates positively with low-density lipoprotein (LDL) particle size, and negatively with apo A-II and fasting triglyceride (TG) levels. Comparison of plasmalogens in elderly subjects with those of 119 healthy young subjects showed a marked decrease in serum plasmalogens levels by aging.
  
  
  CONCLUSIONS
  These results suggest that serum plasmalogens, antioxidant phospholipids, function as a beneficial factor as well as HDL, and that the measurement of serum plasmalogens is useful in clinical diagnosis.
authors.affiliation: Department of Biochemistry, Teikyo University School of Medicine, Tokyo, Japan. maeba@med.teikyo-u.ac.jp
authors.forename: Ryouta
authors.initials: R
authors.lastname: Maeba
authors.forename: Tomomi
authors.initials: T
authors.lastname: Maeda
authors.forename: Makoto
authors.initials: M
authors.lastname: Kinoshita
authors.forename: Kosuke
authors.initials: K
authors.lastname: Takao
authors.forename: Hideki
authors.initials: H
authors.lastname: Takenaka
authors.forename: Jyun
authors.initials: J
authors.lastname: Kusano
authors.forename: Nakayuki
authors.initials: N
authors.lastname: Yoshimura
authors.forename: Yoko
authors.initials: Y
authors.lastname: Takeoka
authors.forename: Daijiro
authors.initials: D
authors.lastname: Yasuda
authors.forename: Tomoki
authors.initials: T
authors.lastname: Okazaki
authors.forename: Tamio
authors.initials: T
authors.lastname: Teramoto
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging / Q000097:blood*; D016632:Apolipoprotein A-I / Q000097:blood; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000097:blood / Q000175:diagnosis; D005260:Female; D006801:Humans; D008075:Lipoproteins, HDL / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010955:Plasmalogens / Q000097:blood*
chemical_list: D016632:Apolipoprotein A-I; D015415:Biomarkers; D008075:Lipoproteins, HDL; D010955:Plasmalogens; C032459:choline plasmalogens; C020791:phosphatidal ethanolamines