title: Searching for non-invasive markers of tissue hypoxia.
abstract: Tissue hypoxia is a common end product of circulatory shock and a primary target for resuscitation efforts. In this issue Podbregar and Mozina show that thenar tissue O2 saturation (StO2) and mixed venous O2 saturation (SvO2) co-vary in patients in left ventricular failure, but in patients with sepsis StO2 was higher than SvO2. Although StO2 may co-vary with SvO2 they have different determinants such that after shock StO2 may increase well before SvO2 as a result of increased O2 demands to repay O2 debt incurred during hypoperfusion. Thus, the use of StO2 alone to define the endpoint of resuscitation may be misleading.
authors.affiliation: Applied Research IMITs Center, Innovative Medical & Information Technology Center, UPMC, F1265 Presbyterian, Pittsburgh, PA 15213-2536, USA.
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: Puyana
authors.forename: Michael R
authors.initials: MR
authors.lastname: Pinsky
mesh_terms: D015415:Biomarkers / Q000378:metabolism; D002303:Cardiac Output, Low / Q000378:metabolism; D006333:Heart Failure / Q000378:metabolism*; D006801:Humans; D000860:Hypoxia / Q000175:diagnosis* / Q000378:metabolism; D018482:Muscle, Skeletal / Q000378:metabolism*; D010100:Oxygen / Q000378:metabolism*; D018805:Sepsis / Q000378:metabolism; D018487:Ventricular Dysfunction, Left / Q000378:metabolism
chemical_list: D015415:Biomarkers; D010100:Oxygen