Central administration of melanocortin agonist increased insulin sensitivity in diet-induced obese rats.
In this study, we examined the effects of intracerebroventricular administration of melanotan II (MTII), a melanocortin agonist, on insulin sensitivity in diet-induced obese (DIO) rats. Although MTII treatment significantly decreased food intake and body weight for 10 days, there was no significant difference in body weight between MTII and pair-fed groups. The insulin tolerance test showed that insulin sensitivity was significantly improved in the MTII group compared to the pair-fed group. Furthermore, MTII treatment increased the number of small-sized adipocytes in epididymal white adipose tissues, suggesting that MTII increased insulin sensitivity through action on the white adipose tissues in DIO rats.
Banno
Ryoichi
R
Department of Endocrinology and Diabetes, Field of Internal Medicine, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan.
Arima
Hiroshi
H
Hayashi
Masayuki
M
Goto
Motomitsu
M
Watanabe
Minemori
M
Sato
Ikuko
I
Ozaki
Nobuaki
N
Nagasaki
Hiroshi
H
Ozaki
Noriyuki
N
Oiso
Yutaka
Y
D017667:Adipocytes / Q000166:cytology / Q000187:drug effects; D052436:Adipose Tissue, White / Q000166:cytology / Q000187:drug effects; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D016207:Cytokines / Q000097:blood; D004032:Diet; D004435:Eating / Q000187:drug effects; D007328:Insulin / Q000494:pharmacology*; D007333:Insulin Resistance; D008297:Male; D053486:Melanocortins / Q000819:agonists*; D009765:Obesity; D010456:Peptides, Cyclic / Q000008:administration & dosage*; D051381:Rats; D017207:Rats, Sprague-Dawley; D000521:alpha-MSH / Q000008:administration & dosage / Q000031:analogs & derivatives*
D016207:Cytokines; D007328:Insulin; D053486:Melanocortins; D010456:Peptides, Cyclic; C079282:melanotan-II; D000521:alpha-MSH