title: MX1 exon 13 polymorphisms in broiler breeder chickens and associations with commercial traits.
abstract: The Mx1 gene in mice is induced by type I interferons and is the major determinant of resistance to influenza virus and related orthomyxoviruses. It has been previously shown that a SNP in exon 13 of the chicken MX1 gene determines differential antiviral activity of the protein. We evaluated this SNP and two additional SNPs in elite broiler lines by PCR amplification and sequence analysis. Associations between MX1 exon 13 SNPs and several traits of economic interest were evaluated. Significant associations were found between the SNP determining antiviral activity and mortality in one line and leg defects in another line.
authors.affiliation: Department of Pathobiology, Auburn University, Auburn, AL 36849-5519, USA.
authors.forename: E J
authors.initials: EJ
authors.lastname: Livant
authors.forename: S
authors.initials: S
authors.lastname: Avendano
authors.forename: S
authors.initials: S
authors.lastname: McLeod
authors.forename: X
authors.initials: X
authors.lastname: Ye
authors.forename: S J
authors.initials: SJ
authors.lastname: Lamont
authors.forename: J C M
authors.initials: JC
authors.lastname: Dekkers
authors.forename: S J
authors.initials: SJ
authors.lastname: Ewald
mesh_terms: D000818:Animals; D001835:Body Weight / Q000235:genetics; D001947:Breeding / Q000379:methods*; D002645:Chickens / Q000235:genetics*; D017931:DNA Primers; D005091:Exons / Q000235:genetics*; D019204:GTP-Binding Proteins / Q000235:genetics*; D006239:Haplotypes / Q000235:genetics; D016014:Linear Models; D064547:Myxovirus Resistance Proteins; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D017422:Sequence Analysis, DNA
chemical_list: D017931:DNA Primers; C579070:Mx1 protein, mouse; D064547:Myxovirus Resistance Proteins; D019204:GTP-Binding Proteins