title: Three men, a paint brush and a coronavirus.
abstract: Coronaviruses cause respiratory tract infection and a coryzal syndrome. Although described as a cause of gastroenteritis in HIV patients, with the exception of the severe acute respiratory syndrome (SARS), there is little in the literature about respiratory infection in HIV patients. We describe two patients with HIV, exacerbations of chronic obstructive pulmonary disease and proven coronavirus infection. A third patient presented with an upper respiratory tract infection but coronavirus was not isolated. All three men had spent a day decorating the first patient's flat four days prior to presentation. This is the first description of respiratory tract infection with coronavirus in HIV patients. Both patients with coronavirus required prolonged admission to hospital and extensive investigations because they were HIV infected. Coronavirus is often associated with less severe upper respiratory tract infection but can cause more severe disease and should be considered in patients with HIV and respiratory tract infection.
authors.affiliation: Brownlee Centre, Gartnavel General Hospital, 1053 Great Western Road, Glasgow, G12 0YN, UK. allymac@doctors.org.uk
authors.forename: A A
authors.initials: AA
authors.lastname: Macconnachie
authors.forename: T C
authors.initials: TC
authors.lastname: Collins
authors.forename: R A
authors.initials: RA
authors.lastname: Seaton
authors.forename: D H
authors.initials: DH
authors.lastname: Kennedy
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000635:transmission / Q000821:virology; D000328:Adult; D018352:Coronavirus Infections / Q000150:complications* / Q000635:transmission / Q000821:virology; D028962:Coronavirus OC43, Human / Q000145:classification / Q000235:genetics / Q000302:isolation & purification; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D029424:Pulmonary Disease, Chronic Obstructive / Q000150:complications* / Q000821:virology; D012141:Respiratory Tract Infections / Q000150:complications* / Q000635:transmission / Q000821:virology