title: Synthesis and antibacterial activity of levofloxacin derivatives with certain bulky residues on piperazine ring.
abstract: A number of levofloxacin analogues carrying a 2-aryl-2-oxoethyl or a 2-aryl-2-oxyiminoethyl moiety attached to the piperazine ring at C-10 position have been prepared and evaluated as antibacterial agents against a series of Gram-positive and Gram-negative bacteria. Some of them exhibited significant inhibitory activity against Gram-positive bacteria.
authors.affiliation: Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran 14174, Iran.
authors.forename: Alireza
authors.initials: A
authors.lastname: Foroumadi
authors.forename: Saeed
authors.initials: S
authors.lastname: Emami
authors.forename: Shahla
authors.initials: S
authors.lastname: Mansouri
authors.forename: Azita
authors.initials: A
authors.lastname: Javidnia
authors.forename: Nosratollah
authors.initials: N
authors.lastname: Saeid-Adeli
authors.forename: Farshad H
authors.initials: FH
authors.lastname: Shirazi
authors.forename: Abbas
authors.initials: A
authors.lastname: Shafiee
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D064704:Levofloxacin; D015394:Molecular Structure; D015242:Ofloxacin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D064704:Levofloxacin; D015242:Ofloxacin