title: PerfTool: a software platform for investigating bolus-tracking perfusion imaging quantification strategies.
abstract: OBJECTIVE
  To develop a software platform, PerfTool (for perfusion tool), for the comprehensive evaluation of bolus-tracking quantitative perfusion imaging methods and algorithms, along with a method to rapidly visualize and evaluate the performance of algorithms.
  
  
  METHODS
  Algorithms were evaluated interactively with PerfTool using synthetic DeltaR2* data sets with different perfusion parameter permutations (known as test patterns). Patient data and test patterns were used to evaluate a standard singular value deconvolution (SVD) approach (sSVD) and a reformulated implementation (rSVD) that is insensitive to arterial-tissue delay (ATD), and to explore the effect of the SVD regularization parameter (p(SVD)) on CBF estimates.
  
  
  RESULTS
  The CBF overestimation resulting from sensitivity to ATD in sSVD compared to rSVD was demonstrated with the patient data, and the effect was confirmed using a test pattern. The same test pattern demonstrated the CBF underestimation resulting from high p(SVD) thresholds.
  
  
  CONCLUSIONS
  PerfTool is an extensible software tool that allows perfusion measurements to be obtained by different methods, and is flexible enough to incorporate new developments and apply them to real patient data and test patterns.
authors.affiliation: Department of Electrical and Computer Engineering, University of Calgary, Calgary, Alberta, Canada.
authors.forename: Jayme C
authors.initials: JC
authors.lastname: Kosior
authors.forename: Richard
authors.initials: R
authors.lastname: Frayne
mesh_terms: D000465:Algorithms; D001921:Brain / Q000098:blood supply / Q000473:pathology*; D001931:Brain Mapping / Q000379:methods; D002560:Cerebrovascular Circulation / Q000502:physiology*; D003287:Contrast Media / Q000008:administration & dosage*; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D018810:Magnetic Resonance Angiography / Q000379:methods*; D012984:Software; D020521:Stroke / Q000175:diagnosis*
chemical_list: D003287:Contrast Media