Synthesis of novel and uniquely shaped 3-azabicyclo[4.2.0]octan-4-one derivatives by sequential Ugi/[2+2] ene-enone photocycloadditions.
[structure: see text]. We report a new methodology for the construction of novel and uniquely shaped 3-azabicyclo[4.2.0]octan-4-one derivatives by combining the Ugi multicomponent reaction with [2+2] enone-olefin photochemical transformations. The overall sequence is capable of creating up to five stereocenters; however, in most cases, only two diastereomers are observed.
Akritopoulou-Zanze
Irini
I
Scaffold Oriented Synthesis and Structural Chemistry, Abbott Laboratories, R4CP, AP10, Abbott Park, IL 60064-6099, USA. irini.zanze@abbott.com
Whitehead
Alan
A
Waters
Jan E
JE
Henry
Rodger F
RF
Djuric
Stevan W
SW