title: Population genetic data on four STR loci, PAI (CA)n, GpIIIa (CT)n, PLAT (TG)14 (CA)12, and NOS2A (CCTTT)n, in Mediterranean populations.
abstract: In the present study, we have analyzed four highly polymorphic regions (STRs) chosen from four candidate genes involved in: (1) Platelet aggregation: alpha subunit of the platelet GpIIb/GpIIIa integrin complex (GpIIIa (CT)n; 17q21.31), (2) Coagulation fibrinolysis: Plasminogen Activator Tissue (PLAT5 (TG)14(TA)12; 8p12-q11.2) and Plasminogen Activator Inhibitor-1 (PAI-1 (CA)n; 7q21.3-q22), (3) Oxidative metabolism: the inducible nitric oxide (NO) synthase (iNOS) gene (NOS2A (CCTTT)n; 17cen-q11.2). Allele frequencies for these four STR loci were investigated in several Mediterranean populations. The population data deviate from the Hardy-Weinberg equilibrium in all populations for GpIIIa (CT)n polymorphism.
authors.affiliation: Department of Human Genetics, Faculty of Science, University of Corsica, BP52 20250 Corte Corsica, France. falchi@univ-corse.fr
authors.forename: Alessandra
authors.initials: A
authors.lastname: Falchi
authors.forename: Ignazio Stefano
authors.initials: IS
authors.lastname: Piras
authors.forename: Laurianne
authors.initials: L
authors.lastname: Giovannoni
authors.forename: Pedro
authors.initials: P
authors.lastname: Moral
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Vona
authors.forename: Laurent
authors.initials: L
authors.lastname: Varesi
mesh_terms: D000352:Africa, Northern; D000483:Alleles; D016009:Chi-Square Distribution; D003627:Data Interpretation, Statistical; D005602:France; D005787:Gene Frequency; D005828:Genetics, Population; D006801:Humans; D039661:Integrin beta3 / Q000235:genetics*; D007558:Italy; D019083:Mediterranean Region; D018895:Microsatellite Repeats; D052247:Nitric Oxide Synthase Type II / Q000235:genetics*; D017395:Plasminogen Activator Inhibitor 1 / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012802:Sicily; D013030:Spain; D010959:Tissue Plasminogen Activator / Q000235:genetics*; D044465:White People / Q000235:genetics*
chemical_list: D039661:Integrin beta3; D017395:Plasminogen Activator Inhibitor 1; C496319:NOS2 protein, human; D052247:Nitric Oxide Synthase Type II; D010959:Tissue Plasminogen Activator