Antifertility activity of hydroalcoholic extract of Ailanthus excelsa (Roxb): an ethnomedicines used by tribals of Nilgiris region in Tamilnadu.
The practice of traditional medicine for the control of fertility in Nilgris is based on the use of plant medicine for many years. The aim of the present study is to evaluate the effect of hydroalcoholic extract of stem bark of Ailanthus excelsa Roxb (Simaroubaceae) (HEA) has been studied in rats to explore its antifertility activity. A strong antiimplantation (72%) and abortifacient activity (56%) was observed at the tested dose levels (200 and 400mg/kg, p.o.). The extract shows further more, significant (P<0.05) increase in uterine weight in immature ovariectomised rats. Simultaneous administration of extract with ethinyl estradiol cause significant antiestrogenic activity. All these observations suggest that hydroalcoholic extract of Ailanthus excelsa has antifertility effect.
Ravichandran
V
V
Department of Pharmacognosy and Phytochemistry, Jaya College of Paramedical Sciences, Thiruninravur, Chennai 602204, India. raviphd2005@yahoo.co.in
Suresh
B
B
Sathishkumar
M N
MN
Elango
K
K
Srinivasan
R
R
D000019:Abortifacient Agents / Q000494:pharmacology*; D032268:Ailanthus; D000818:Animals; D003270:Contraceptive Agents / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D010064:Embryo Implantation / Q000187:drug effects; D020847:Estrogen Receptor Modulators / Q000494:pharmacology; D004967:Estrogens / Q000494:pharmacology; D004997:Ethinyl Estradiol / Q000494:pharmacology; D005260:Female; D005298:Fertility / Q000187:drug effects*; D007194:India; D008297:Male; D008518:Medicine, East Asian Traditional; D009929:Organ Size / Q000187:drug effects; D010052:Ovariectomy; D024301:Plant Bark; D010936:Plant Extracts; D051381:Rats; D017208:Rats, Wistar; D014599:Uterus / Q000187:drug effects
D000019:Abortifacient Agents; D003270:Contraceptive Agents; D020847:Estrogen Receptor Modulators; D004967:Estrogens; D010936:Plant Extracts; D004997:Ethinyl Estradiol