Acquired echinocandin resistance in a Candida krusei isolate due to modification of glucan synthase.
A Candida krusei strain from a patient with acute myelogenous leukemia that displayed reduced susceptibility to echinocandin drugs contained a heterozygous mutation, T2080K, in FKS1. The resulting Phe655-->Cys substitution altered the sensitivity of glucan synthase to echinocandin drugs, consistent with a common mechanism for echinocandin resistance in Candida spp.
Kahn
Jennifer Nielsen
JN
PHRI, Newark, NJ 07103, USA.
Garcia-Effron
Guillermo
G
Hsu
Ming-Jo
MJ
Park
Steven
S
Marr
Kieren A
KA
Perlin
David S
DS
D000595:Amino Acid Sequence; D000077612:Anidulafungin; D000935:Antifungal Agents / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects* / Q000201:enzymology / Q000235:genetics; D000077336:Caspofungin; D025141:Drug Resistance, Fungal; D054714:Echinocandins; D005964:Glucosyltransferases / Q000737:chemistry / Q000235:genetics*; D055666:Lipopeptides; D008074:Lipoproteins / Q000494:pharmacology*; D000077551:Micafungin; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D010456:Peptides, Cyclic / Q000494:pharmacology*; D021122:Protein Subunits
D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D008074:Lipoproteins; D010456:Peptides, Cyclic; D021122:Protein Subunits; D000077612:Anidulafungin; D005964:Glucosyltransferases; C040232:glucan synthase; D000077336:Caspofungin; D000077551:Micafungin