title: [Comparison of model for end-stage liver disease score with discriminant function and child-Turcotte-Pugh scores for predicting short-term mortality in Korean patients with alcoholic hepatitis].
abstract: OBJECTIVE
  Alcoholic hepatitis is an acute or acute-on-chronic inflammatory syndrome associated with significant morbidity and mortality. Traditionally, Maddrey discriminant function (DF) score and Child-Turcott-Pugh (CTP) score have been used for stratifying the prognosis of alcoholic hepatitis. Recently, the model for end-stage liver disease (MELD) score has been applied to alcoholic hepatitis and some investigators consider MELD score as a better prognostic indicator for severe alcoholic hepatitis. Therefore, this analysis was aimed to compare MELD score with DF and CTP scores for predicting the short-term mortality in Korean patients with alcoholic hepatitis.
  
  
  METHODS
  The medical records of patients hospitalized with alcoholic hepatitis between January 1, 1999 and December 31, 2004 at Hanyang University Guri-Hospital were analyzed retrospectively.
  
  
  RESULTS
  Of the 138 medical records reviewed, 74 cases fulfilled the inclusion criteria (61 males and 13 females; mean age 47.1 years). Twelve patients (16.2%) died within 90 days after admission. Univariate analysis demonstrated that variables such as ascites, hepatic encephalopathy, splenomegaly, international normalized ratio, CTP, and DF scores were significantly correlated with increased 90-day mortality while MELD score was not. According to the multivariate analysis, only CTP score was statistically significant (p=0.012) while DF and MELD scores were not significant for predicting 90-day mortality. The survival analysis with Cox regression test showed higher DF and CTP scores, but not MELD score, significantly increased the risk of in-hospital mortality.
  
  
  CONCLUSIONS
  This study demonstrates that DF and CTP scores are independent predictors of short-term mortality in patients with alcoholic hepatitis.
authors.affiliation: Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea.
authors.forename: Jae Yoon
authors.initials: JY
authors.lastname: Jeong
authors.forename: Joo Hyun
authors.initials: JH
authors.lastname: Sohn
authors.forename: Byoung Kwan
authors.initials: BK
authors.lastname: Son
authors.forename: Chang Hee
authors.initials: CH
authors.lastname: Paik
authors.forename: Seok Hwan
authors.initials: SH
authors.lastname: Kim
authors.forename: Dong Soo
authors.initials: DS
authors.lastname: Han
authors.forename: Yong Chul
authors.initials: YC
authors.lastname: Jeon
authors.forename: Min Ho
authors.initials: MH
authors.lastname: Lee
authors.forename: Dong Hoo
authors.initials: DH
authors.lastname: Lee
authors.forename: Choon Suk
authors.initials: CS
authors.lastname: Kee
mesh_terms: D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D006519:Hepatitis, Alcoholic / Q000175:diagnosis / Q000401:mortality*; D006801:Humans; D007723:Korea; D008107:Liver Diseases / Q000175:diagnosis / Q000401:mortality; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011379:Prognosis; D012372:ROC Curve; D012720:Severity of Illness Index; D016019:Survival Analysis; D013997:Time Factors