Design and synthesis of metal-free artificial ribonucleases.
The present review is aimed at giving a general overview of our results in the field of designing and synthesizing simple peptide-like molecules that mimic structural and functional aspects of natural ribonucleases, as well as designing oligonucleotide-based artificial ribonucleases.
Koroleva
Ludmila S
LS
Institute of Chemical Biology and Fundamental Medicine, Novosibirsk, Russia. koroleva@niboch.nsc.ru
Serpokrylova
Inna Yu
IY
Vlassov
Valentin V
VV
Silnikov
Vladimir N
VN
D000595:Amino Acid Sequence; D001483:Base Sequence; D008670:Metals / Q000737:chemistry; D008958:Models, Molecular; D008969:Molecular Sequence Data; D009690:Nucleic Acid Conformation; D009841:Oligonucleotides / Q000737:chemistry / Q000378:metabolism; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry; D012313:RNA / Q000737:chemistry / Q000378:metabolism; D012260:Ribonucleases / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D013379:Substrate Specificity
D008670:Metals; D009841:Oligonucleotides; D010455:Peptides; D012313:RNA; D012260:Ribonucleases