title: Long-term survival in a randomized study of nonplatinum therapy versus platinum in advanced epithelial ovarian cancer.
abstract: The purpose of this study was to compare long-term survival in first-line chemotherapy with and without platinum in advanced-stage ovarian cancer. From July 1987 to November 1992, 161 untreated patients with FIGO stage III-IV epithelial ovarian cancer were randomized: 81 patients received no platinum and 80 received platinum combination. Residual disease after surgery was <2 cm in 61 patients without platinum, 59 with platinum. Median age was 58 years in nonplatinum arm and 55 years in platinum arm (range: 15-73). Complete and partial responses were 51% and 10% for nonplatinum arm and 51% and 8% for platinum arm, respectively (P= 0.7960). Stable disease was observed in 18% of patients in nonplatinum arm and 15% of patients in platinum arm and progression in 20% of nonplatinum- and 21% of platinum-treated cases. Ten-year disease-free survival was 37% for therapy without platinum and 31% for platinum combination (P= 0.5679); 10-year overall survival was 23% without platinum and 31% with platinum combination (P= 0.2545). Fifteen-year overall survival showed a trend of short duration in favor of platinum (P= 0.0678). Relapses occurred after 60 months in ten patients (seven with and three without platinum). The overall and disease-free survivals at 5, 10, and 15 years show no statistically significant long-term advantage from the addition of cisplatin; however, there is a slight trend in its favor.
authors.affiliation: U.O.C. Medical Oncology Department, Istituto Oncologico Veneto, Padua, Italy. mariaorn@libero.it
authors.forename: M O
authors.initials: MO
authors.lastname: Nicoletto
authors.forename: S
authors.initials: S
authors.lastname: Tumolo
authors.forename: R
authors.initials: R
authors.lastname: Sorio
authors.forename: G
authors.initials: G
authors.lastname: Cima
authors.forename: L
authors.initials: L
authors.lastname: Endrizzi
authors.forename: O
authors.initials: O
authors.lastname: Nascimben
authors.forename: O
authors.initials: O
authors.lastname: Vinante
authors.forename: G
authors.initials: G
authors.lastname: Artioli
authors.forename: M
authors.initials: M
authors.lastname: Donach
authors.forename: G
authors.initials: G
authors.lastname: Cartei
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002277:Carcinoma / Q000188:drug therapy*; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000188:drug therapy*; D017671:Platinum Compounds / Q000627:therapeutic use*
chemical_list: D017671:Platinum Compounds