title: Methyl 2-(2-(4-formylphenoxy)acetamido)-2-substituted acetate derivatives: a new class of acetylcholinesterase inhibitors.
abstract: A new class of inhibitors of acetylcholinesterase (methyl 2-(2-(4-formylphenoxy)acetamido)-2-substituted acetate derivatives) is described. Compounds 4b and 4i were found to be more potent than galanthamine in inhibiting acetylcholinesterase.
authors.affiliation: School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China.
authors.forename: Huan
authors.initials: H
authors.lastname: Wen
authors.forename: Yayao
authors.initials: Y
authors.lastname: Zhou
authors.forename: Chonglan
authors.initials: C
authors.lastname: Lin
authors.forename: Hui
authors.initials: H
authors.lastname: Ge
authors.forename: Lin
authors.initials: L
authors.lastname: Ma
authors.forename: Zihou
authors.initials: Z
authors.lastname: Wang
authors.forename: Wenlie
authors.initials: W
authors.lastname: Peng
authors.forename: Huacan
authors.initials: H
authors.lastname: Song
mesh_terms: D000085:Acetates / Q000138:chemical synthesis* / Q000494:pharmacology; D000544:Alzheimer Disease / Q000188:drug therapy; D001547:Benzaldehydes / Q000138:chemical synthesis* / Q000494:pharmacology; D002800:Cholinesterase Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D020128:Inhibitory Concentration 50; D013329:Structure-Activity Relationship
chemical_list: D000085:Acetates; D001547:Benzaldehydes; D002800:Cholinesterase Inhibitors; C011483:4-hydroxybenzaldehyde