Impact of surgical procedures and complications on outcomes of third and subsequent kidney transplants.
BACKGROUND
Surgical procedures and complications have rarely been described in patients receiving a third or subsequent renal transplant.


METHODS
Data from 61 consecutive third (n=56), fourth (n=4), and fifth (n=1) renal transplants performed during 1974 to 2005 were analyzed retrospectively.


RESULTS
Actuarial graft survival was 91%, 74%, and 57% at one, five, and 10 years, respectively. Technical failure accounted for the loss of three grafts (5%). A transperitoneal approach was necessary in 41% of patients. Technical difficulties occurred in half of the procedures, mainly due to atheroma or vascular calcifications. Overall, there were 45 surgical complications in 30 patients, of urological (n=11), vascular (n=6), infectious (n=9), hemorrhagic (n=12), digestive (n=3), or wound origin (n=4). The rate of surgical revision was 16%. Univariate analysis showed that among surgical complications, only vascular complications were associated with a poor graft outcome (P=0.02). Urological complications did not influence long-term graft outcome. Multivariate analysis of all surgical procedures and complications that might have influenced graft survival showed that only vascular complications were associated with a poorer graft outcome (relative risk=6.13, P=0.015).


CONCLUSIONS
Despite a high rate of surgical complications and revisions, third and subsequent kidney transplantations may be performed safely by experienced surgeons without surgical complications influencing long-term graft outcome.
Loupy
Alexandre
A
Service de Transplantation Rénale, Hôpital Necker, Paris, France.
Anglicheau
Dany
D
Timsit
Marc Olivier
MO
Thervet
Eric
E
Mamzer-Bruneel
Marie-France
MF
Martinez
Frank
F
Desgranchamps
François
F
Thiounn
Nicolas
N
Kreis
Henri
H
Legendre
Christophe
C
Chrétien
Yves
Y
Méjean
Arnaud
A
D000328:Adult; D005260:Female; D006084:Graft Rejection; D006085:Graft Survival; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D015996:Survival Rate; D019172:Transplantation Conditioning; D016896:Treatment Outcome; D014570:Urologic Diseases / Q000150:complications / Q000601:surgery