Sinugrandisterols A-D, trihydroxysteroids from the soft coral Sinularia grandilobata.
Four new trihydroxysteroids, sinugrandisterols A-D (1-4), have been isolated from the CH(2)Cl(2)-soluble fraction of the EtOH extract of Sinularia grandilobata. The structures of these metabolites were determined on the basis of spectroscopic (IR, MS, and 1D and 2D NMR) analysis. The cytotoxicity of 1-4 toward a limited panel of cancer cell lines is also reported.
Ahmed
Atallah F
AF
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan.
Tai
Shu-Hui
SH
Wu
Yang-Chang
YC
Sheu
Jyh-Horng
JH
D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D002775:Cholestadienols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D006888:Hydroxycholesterols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006914:Hydroxysteroids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D013055:Spectrophotometry, Infrared; D014407:Tumor Cells, Cultured
C520758:24-methylenecholest-5-en-1,3,7-triol; C520760:5,6-epoxy-24-methylenecholesta-1,3,7-triol; C520759:5,6-epoxy-24-methylenecholesta-5,22-dien-1,3,7-triol; D000970:Antineoplastic Agents; D002775:Cholestadienols; D006888:Hydroxycholesterols; D006914:Hydroxysteroids