A general model for the dynamics of the cell volume.
The conservation of the cell volume within values compatible with the overall cell functions represents an ubiquitous property, shared by cells comprising the whole biological world. Water transport across membranes constitutes the main process associated to the dynamics of the cell volume, its chronic and acute regulations therefore represent crucial aspects of cell homeostasis. In spite of the biological diversity, the dynamics of the cell volume exhibits common basic features in the diverse types of cells. The purpose of this study is to show that there is a general model capable to describe the basic aspects of the dynamics of the cell volume. It is demonstrated here that the steady states of this model represent asymptotically stable configurations. As illustrations, several cases of non-polarized (i.e., symmetrical) and polarized (e.g., epithelial) cells performing water transport are shown here to represent particular cases of the general model. From a biological perspective, the existence of a general model for the dynamics of the cell volume reveals that, in spite of physiological and morphological peculiarities, there is a basic common design of the membrane transport processes. In view of its stability properties, this basic design may represent an ancestral property that has proven to be successful regarding the overall homeostatic properties of cells.
Hernández
Julio A
JA
Sección Biofísica, Facultad de Ciencias, Universidad de la República, Iguá esq. Mataojo, 11400 Montevideo, Uruguay. jahern@fcien.edu.uy
D000465:Algorithms; D000818:Animals; D001692:Biological Transport / Q000502:physiology; D048429:Cell Size; D004847:Epithelial Cells / Q000378:metabolism / Q000502:physiology; D005057:Eukaryotic Cells / Q000378:metabolism / Q000502:physiology; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D026901:Membrane Transport Proteins / Q000378:metabolism; D008954:Models, Biological; D009994:Osmolar Concentration; D014867:Water / Q000378:metabolism
D026901:Membrane Transport Proteins; D014867:Water