Prolyl cis-trans Isomerization as a molecular timer in Crk signaling.
In a recent issue of Molecular Cell, use NMR to identify peptidyl-prolyl cis-trans isomerization as an autoinhibitory switch in the adaptor protein Crk, suggesting a new mechanism for controlling the rate of formation of signaling complexes.
Nicholson
Linda K
LK
Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA. lkn2@cornell.edu
Lu
Kun Ping
KP
D007536:Isomerism; D009682:Magnetic Resonance Spectroscopy; D019696:Peptidylprolyl Isomerase / Q000378:metabolism; D011392:Proline / Q000737:chemistry*; D011487:Protein Conformation; D050737:Proto-Oncogene Proteins c-crk / Q000737:chemistry / Q000378:metabolism*; D015398:Signal Transduction; D013816:Thermodynamics; D018909:src Homology Domains
D050737:Proto-Oncogene Proteins c-crk; D011392:Proline; D019696:Peptidylprolyl Isomerase