title: An automated method for measuring static pressure-volume curves of the respiratory system and its application in healthy lungs and after lung damage by oleic acid infusion.
abstract: Elastic pressure/volume (PV) curves of the respiratory system have attracted increasing interest, because they may be helpful to optimize ventilator settings in patients undergoing mechanical ventilation. Clinically applicable methods need to be fast, use routinely available equipment, draw the inspiratory and expiratory PV curve limbs, separate the resistive and viscoelastic properties of the respiratory system from the elastic properties, and provide reproducible measurements. This paper presents a computer-controlled method for rapid measurements of static PV curves using a long inflation-deflation with pauses, and its evaluation in six pigs before and after lung damage caused by oleic acid. The method is fast, i.e. 20.5 +/- 1.9 s (mean +/- SD) in healthy lungs and 17.7 +/- 4.1 s in diseased lungs, this including inspiratory and expiratory pauses of 1.1 s duration. In addition the only equipment used was a clinical ventilator and a PC. For healthy and damaged lungs expiratory PV curve limbs were very reproducible and were at higher volume than the inspiratory limbs, indicating hysteresis. For damaged lungs inspiratory PV limbs were reproducible. For healthy lungs the inspiratory limbs were reproducible but only after the first inflation-deflation. It is possible that during the first inflation alveoli are recruited which are not derecruited on deflation, shifting the inspiratory limb of the PV curve. The paused long inflation-deflation technique provides a quick, automated measurement of static PV curves on both inspiratory and expiratory limbs using routinely available equipment in the intensive care unit.
authors.affiliation: Center for Model-Based Medical Decision Support, Institute for Health Science and Technology, Aalborg University, Niels Jernes Vej 14, 4-311, Aalborg East, Denmark.
authors.forename: Y
authors.initials: Y
authors.lastname: Zhao
authors.forename: S E
authors.initials: SE
authors.lastname: Rees
authors.forename: S
authors.initials: S
authors.lastname: Kjaergaard
authors.forename: B W
authors.initials: BW
authors.lastname: Smith
authors.forename: A
authors.initials: A
authors.lastname: Larsson
authors.forename: S
authors.initials: S
authors.lastname: Andreassen
mesh_terms: D000818:Animals; D008168:Lung / Q000502:physiology* / Q000503:physiopathology; D008838:Microcomputers; D019301:Oleic Acid; D012121:Respiration, Artificial; D012129:Respiratory Function Tests; D015656:Respiratory Mechanics / Q000502:physiology*; D013552:Swine
chemical_list: D019301:Oleic Acid