title: Treatment of severe cutaneous ulcerative lichen planus with low molecular weight heparin in a patient with hepatitis C.
abstract: The ulcerative variant of lichen planus (LP) commonly involves the oral mucosa but is uncommon and difficult to treat when located on other areas. We describe an unusual case of ulcerative LP involving several surfaces, including the palms and scrotum, in a 50-year-old man with hepatitis C. The patient was recalcitrant to treatment with conventional therapy but obtained clearance with a sustained response using low molecular weight heparin (LMWH). This treatment is an option for patients with LP who are not ideal candidates for standard therapy.
authors.affiliation: Department of Dermatology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157-1071, USA.
authors.forename: Julie A
authors.initials: JA
authors.lastname: Neville
authors.forename: John G
authors.initials: JG
authors.lastname: Hancox
authors.forename: Phillip M
authors.initials: PM
authors.lastname: Williford
authors.forename: Gil
authors.initials: G
authors.lastname: Yosipovitch
mesh_terms: D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000925:Anticoagulants / Q000627:therapeutic use*; D002990:Clobetasol / Q000627:therapeutic use; D005832:Genital Diseases, Male / Q000188:drug therapy; D006229:Hand Dermatoses / Q000188:drug therapy; D006495:Heparin, Low-Molecular-Weight / Q000627:therapeutic use*; D006526:Hepatitis C / Q000150:complications*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008010:Lichen Planus / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D012611:Scrotum / Q000473:pathology; D012883:Skin Ulcer / Q000188:drug therapy*; D016559:Tacrolimus / Q000627:therapeutic use
chemical_list: D000893:Anti-Inflammatory Agents; D000925:Anticoagulants; D006495:Heparin, Low-Molecular-Weight; D007166:Immunosuppressive Agents; D002990:Clobetasol; D016559:Tacrolimus