title: Changes in autobiographical memory specificity following cognitive behavior therapy and pharmacotherapy for major depression.
abstract: BACKGROUND
  An important cognitive marker of clinical depression is a reduced ability to be specific in recalling personal memories, a phenomenon coined 'overgeneral memory'. Overgeneral memory is considered as a stable cognitive trait that is intrinsically linked with depression and independent of mood state. Previous studies show that autobiographical memory is modifiable.
  
  
  METHODS
  This study investigated whether autobiographical memory is differentially affected by treatment type. Depressed patients were randomly assigned to receive either cognitive behavior therapy (CBT) for depression or pharmacotherapy (PHT).
  
  
  RESULTS
  The proportion of categoric memories decreased and the proportion of specific memories increased following both types of treatments, adding support to the view that overgeneral memory is modifiable. CBT also had a greater impact on reducing extended overgeneral memories compared to PHT.
  
  
  CONCLUSIONS
  The results from the current study are important in that they show that overgeneral memory can be targeted and modified through brief treatment. The clinical significance of the finding that there was a greater decrease in extended memories in the CBT group is unclear.
authors.affiliation: Centre for Addiction and Mental Health, Toronto, Ontario, Canada. carolina_mcbride@camh.net
authors.forename: Carolina
authors.initials: C
authors.lastname: McBride
authors.forename: Zindel
authors.initials: Z
authors.lastname: Segal
authors.forename: Sidney
authors.initials: S
authors.lastname: Kennedy
authors.forename: Michael
authors.initials: M
authors.lastname: Gemar
mesh_terms: D000328:Adult; D000928:Antidepressive Agents / Q000627:therapeutic use*; D001325:Autobiographies as Topic; D015928:Cognitive Behavioral Therapy / Q000379:methods*; D003865:Major Depressive Disorder / Q000188:drug therapy / Q000523:psychology / Q000628:therapy*; D005260:Female; D006801:Humans; D008297:Male; D008569:Memory Disorders / Q000175:diagnosis / Q000453:epidemiology*; D011939:Mental Recall; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000928:Antidepressive Agents