title: Preliminary results on interleukin-4 and interleukin-10 cytokine production in malnourished, inducible nitric oxide synthase-deficient mice with schistosomiasis mansoni infection.
abstract: Schistosoma mansoni infected C57Bl/6 inducible nitric oxide synthase (iNOS)-deficient and non-deficient malnourished mice, both fed a balanced controlled diet were studied. Interleukins, IL-4 and IL-10 responses to soluble egg antigens (SEA) 90 days after infection, were determined. Our results suggest that in iNOS deficient, malnourished mice, 90 days after of infection, nitric oxide has a downregulating effect on IL-4 and IL-10 production. We are currently investigating the biological significance of these findings.
authors.affiliation: Laboratório de Bioquímica e Biologia Molecular, Departamento de Imunologia, Centro de Pesquisas Aggeu Magalhães-Fiocruz, 52020-020 Recife, PE, Brazil.
authors.forename: Renata P
authors.initials: RP
authors.lastname: Ramos
authors.forename: Vlaudia M A
authors.initials: VM
authors.lastname: Costa
authors.forename: Camila F
authors.initials: CF
authors.lastname: Melo
authors.forename: Valdênia M O
authors.initials: VM
authors.lastname: Souza
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Malagueño
authors.forename: Eridan M
authors.initials: EM
authors.lastname: Coutinho
authors.forename: Frederico G C
authors.initials: FG
authors.lastname: Abath
authors.forename: Silvia M I
authors.initials: SM
authors.lastname: Montenegro
mesh_terms: D000818:Animals; D000947:Antigens, Helminth / Q000276:immunology; D004195:Disease Models, Animal; D016753:Interleukin-10 / Q000096:biosynthesis*; D015847:Interleukin-4 / Q000096:biosynthesis*; D008297:Male; D044342:Malnutrition / Q000276:immunology*; D051379:Mice; D008810:Mice, Inbred C57BL; D052247:Nitric Oxide Synthase Type II / Q000172:deficiency*; D010063:Ovum / Q000276:immunology; D012555:Schistosomiasis mansoni / Q000276:immunology*
chemical_list: D000947:Antigens, Helminth; D016753:Interleukin-10; D015847:Interleukin-4; D052247:Nitric Oxide Synthase Type II