title: Intranasal Helicobacter pylori colonization does not correlate with the severity of chronic rhinosinusitis.
abstract: OBJECTIVE
  To investigate the prevalence of Helicobacter pylori (HP) in the nasal cavity of patients with chronic rhinosinusitis (CRS) and to correlate it with the severity of CRS.
  
  
  METHODS
  Intranasal HP was investigated using rapid urease (CLO) testing and immunohistochemical (IHC) analysis and confirmed with transmission electron microscopy. To evaluate the severity of sinusitis, CT scans were graded according to the Lund-MacKay scoring system, and CRS symptom scores were recorded.
  
  
  RESULTS
  Twelve of 48 patients (25.0%) were positive, but only 1 of 29 (3.4%) controls was positive for both CLO testing and IHC analysis (P = 0.025). The mean preoperative CT grade (P = 0.439) and symptom scores (P = 0.515) were not related to the severity of CRS.
  
  
  CONCLUSIONS
  Intranasal HP was more prevalent in patients with CRS than healthy controls. However, there was no significant correlation observed between the severity of sinusitis and intranasal HP colonization.
  
  
  CONCLUSIONS
  HP has a limited role in pathogenesis of CRS.
authors.affiliation: Department of Otorhinolaryngology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors.forename: Hyo Yeol
authors.initials: HY
authors.lastname: Kim
authors.forename: Hun-Jong
authors.initials: HJ
authors.lastname: Dhong
authors.forename: Seung Kyu
authors.initials: SK
authors.lastname: Chung
authors.forename: Kyu Whan
authors.initials: KW
authors.lastname: Chung
authors.forename: Young Jun
authors.initials: YJ
authors.lastname: Chung
authors.forename: Kee-Taek
authors.initials: KT
authors.lastname: Jang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002908:Chronic Disease; D005157:Facial Pain / Q000145:classification; D005260:Female; D016481:Helicobacter Infections / Q000175:diagnosis; D016480:Helicobacter pylori / Q000254:growth & development*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D046529:Microscopy, Electron, Transmission; D008875:Middle Aged; D009296:Nasal Cavity / Q000382:microbiology*; D015508:Nasal Obstruction / Q000145:classification; D000857:Olfaction Disorders / Q000145:classification; D012220:Rhinitis / Q000145:classification / Q000382:microbiology*; D012720:Severity of Illness Index; D012852:Sinusitis / Q000145:classification / Q000382:microbiology*; D013492:Suppuration; D014510:Urease
chemical_list: D014510:Urease