title: Idiopathic hyperplasia of the sublingual glands in totally or partially edentulous individuals.
abstract: OBJECTIVE
  To determine the possible etiologic factors associated with the development of idiopathic hyperplasia of the sublingual gland (IHSG).
  
  
  METHODS
  Fifty partially or totally edentulous patients were divided into 2 groups, each with 25 subjects, matched by sex. Group 1 was made up of patients with IHSG, whereas group 2 consisted of patients without IHSG. Patients of both groups were investigated with respect to the use of prostheses, systemic medication, systemic diseases, smoking habits, alcohol consumption, and xerostomia. In addition, patients of group 1 were examined by occlusal radiography, and in 6 of them, a biopsy of the sublingual gland swelling was taken for histopathologic investigation. The Fisher exact test was used, with significance set for P < or = .05.
  
  
  RESULTS
  The comparative analysis revealed no statistical difference between the 2 groups concerning all factors investigated (P > .05). Radiographic examination did not detect any presence of salivary calculi; the histopathologic findings revealed either chronic sialadenitis (4 cases) or normal glandular tissue (2 cases).
  
  
  CONCLUSIONS
  Our clinical and histopathologic analyses confirm that IHSG is a harmless condition for which no surgical treatment is required. The etiologic investigation did not find any local or systemic factors significantly associated with the development of IHSG. The absence of posterior teeth remains as the only known predisposing factor to be strongly linked to this condition.
authors.affiliation: Department of Oral Diagnosis, School of Dentistry, University of São Paulo, São Paulo, SP, Brazil.
authors.forename: Carina
authors.initials: C
authors.lastname: Domaneschi
authors.forename: Ana R
authors.initials: AR
authors.lastname: Maurício
authors.forename: Filipe
authors.initials: F
authors.lastname: Modolo
authors.forename: Dante A
authors.initials: DA
authors.lastname: Migliari
mesh_terms: D000328:Adult; D000368:Aged; D016009:Chi-Square Distribution; D005260:Female; D006801:Humans; D006965:Hyperplasia; D007575:Jaw, Edentulous / Q000150:complications*; D008297:Male; D008334:Mandible; D008875:Middle Aged; D012466:Salivary Gland Diseases / Q000209:etiology*; D013361:Sublingual Gland / Q000473:pathology*; D011795:Surveys and Questionnaires