Control of peripheral B-cell development.
Three subsets of mature B cells exist in mice: B-1, follicular and marginal zone B cells. The recruitment of newly formed transitional B cells into these compartments depends on signals emanating from the B-cell antigen receptor, possibly in response to (self-)antigen recognition. Recent evidence suggests that peripheral B-cell fate is controlled by B-cell antigen receptor signal strength, acting in concert with the cytokine B-cell activating factor. Other work indicates that peripheral B-cell development is orchestrated by a complex network of transcription factors, which drive B-cell subset differentiation, at the same time preventing mature B cells from undergoing trans-differentiation or premature terminal differentiation.
Casola
Stefano
S
Fondazione Istituto FIRC di Oncologia Molecolare, Via Adamello 16, 20139 Milan, Italy. stefano.casola@ifom-ieo-campus.it <stefano.casola@ifom-ieo-campus.it>
D000818:Animals; D053265:B-Cell Activation Factor Receptor / Q000235:genetics / Q000502:physiology*; D016175:B-Lymphocyte Subsets / Q000276:immunology*; D018507:Gene Expression Regulation, Developmental; D038041:Lymphopoiesis / Q000235:genetics*; D051379:Mice; D011947:Receptors, Antigen, B-Cell / Q000235:genetics / Q000502:physiology*; D014157:Transcription Factors / Q000378:metabolism; D014158:Transcription, Genetic
D053265:B-Cell Activation Factor Receptor; D011947:Receptors, Antigen, B-Cell; D014157:Transcription Factors