title: Permeability of the subsynovial connective tissue in the human carpal tunnel: a cadaver study.
abstract: BACKGROUND
  The purpose of this study was to determine the permeability of the normal carpal tunnel subsynovial connective tissue.
  
  
  METHODS
  Subsynovial connective tissue samples (10mm(2)) were obtained from 10 fresh frozen human cadavers without a history of carpal tunnel syndrome. The thickness of the sample was measured using a charge-coupled device laser displacement system. Each specimen was tested for permeability in a closed pressure chamber at 13.8, 41.3, 68.9 and 96.5 kPa.
  
  
  RESULTS
  Since permeated flow was very low in all specimens, the permeability could be calculated only for eight specimens at 96.5 kPa pressure and for three specimens at 68.9 kPa. The mean permeability at 96.5 kPa was mean 0.89 (SD 0.93)x10(-14)m(4)/Ns and at 68.9 kPa was mean 1.04 (SD 1.54)x10(-14)m(4)/Ns.
  
  
  CONCLUSIONS
  The subsynovial connective tissue is the most characteristic tissue in the carpal tunnel; it is found in no other location in such abundance. It is well known that carpal tunnel syndrome is the result of increased pressure within the carpal tunnel. This lack of permeability in the subsynovial connective tissue may explain the predisposition of this region for pressure buildup and subsequent neuropathy.
authors.affiliation: Biomechanics Laboratory, Division of Orthopedic Research, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA.
authors.forename: Naoki
authors.initials: N
authors.lastname: Osamura
authors.forename: Chunfeng
authors.initials: C
authors.lastname: Zhao
authors.forename: Mark E
authors.initials: ME
authors.lastname: Zobitz
authors.forename: Kai-Nan
authors.initials: KN
authors.lastname: An
authors.forename: Peter C
authors.initials: PC
authors.lastname: Amadio
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001834:Body Water / Q000378:metabolism*; D002102:Cadaver; D002348:Carpal Bones; D050824:Carpal Joints / Q000502:physiology*; D003238:Connective Tissue / Q000502:physiology*; D006801:Humans; D008875:Middle Aged; D010539:Permeability; D013583:Synovial Membrane / Q000502:physiology*; D014867:Water / Q000378:metabolism*
chemical_list: D014867:Water