Effects of adiponectin on the renal sympathetic nerve activity and blood pressure in rats.
Adiponectin is an adipocytokine that modulates energy homeostasis and glucose metabolism. Here, we examined the effects of acute intravenous (iv) and lateral cerebral ventricular (LCV) injections of adiponectin on the renal sympathetic nerve activity (RSNA) and blood pressure (b/p) in urethane-anesthetized rats. Both iv and LCV injections of adiponectin induced dose-dependent suppressions of RSNA and b/p. Moreover, we found that bilateral lesions of the hypothalamic suprachiasmatic nucleus (SCN) abolished the effects of iv injection of adiponectin on RSNA and b/p. These findings suggest that adiponectin decreases the RSNA and b/p in a dose-dependent manner and that the SCN is implicated in mechanism of adiponectin actions on RSNA and b/p. These findings also suggest that the hypotensive-action activity of adiponectin is realized, at least partially, via changes in activities of autonomic nerves activity.
Tanida
Mamoru
M
Division of Protein Metabolism, Institute for Protein Research, Osaka University, Osaka, Japan 565-0871. mtanida@ymp-i.co.jp
Shen
Jiao
J
Horii
Yuko
Y
Matsuda
Morihiro
M
Kihara
Shinji
S
Funahashi
Toru
T
Shimomura
Iichiro
I
Sawai
Hajime
H
Fukuda
Yutaka
Y
Matsuzawa
Yuji
Y
Nagai
Katsuya
K
D052242:Adiponectin / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D006339:Heart Rate / Q000187:drug effects; D018738:Hexamethonium / Q000494:pharmacology; D007275:Injections, Intravenous; D007668:Kidney / Q000294:innervation*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013493:Suprachiasmatic Nucleus / Q000502:physiology / Q000601:surgery; D013564:Sympathetic Nervous System / Q000187:drug effects* / Q000502:physiology
D052242:Adiponectin; D001786:Blood Glucose; D018738:Hexamethonium