title: Synthesis and in vitro cytotoxicity of novel lipophilic (diamine)platinum(II) complexes of salicylate derivatives.
abstract: Novel lipophilic (diamine)platinum(II) complexes of salicylate derivatives as the leaving groups were synthesized and characterized by elemental analysis, FAB(+)-MS, FT-IR, and (1)H NMR spectroscopy. Most of the resulting platinum complexes had high solubility in organic solvents such as ethanol, acetone, and ether, and had right partition coefficient suited to be encapsulated in liposomes. The pertinent complexes were evaluated for their in vitro cytotoxicity against A549 human lung carcinoma and SGC-7901 human gastric carcinoma cell lines. They showed better cytotoxic activity than carboplatin and oxaliplatin.
authors.affiliation: Platinum-Based Drug Lab, Kunming Institute of Precious Metals, Kunming 650021, China.
authors.forename: Qing-Song
authors.initials: QS
authors.lastname: Ye
authors.forename: Li-Guang
authors.initials: LG
authors.lastname: Lou
authors.forename: Wei-Ping
authors.initials: WP
authors.lastname: Liu
authors.forename: Yao
authors.initials: Y
authors.lastname: Yu
authors.forename: Xi-Zhu
authors.initials: XZ
authors.lastname: Chen
authors.forename: Shu-Qian
authors.initials: SQ
authors.lastname: Hou
authors.forename: Wen-Qui
authors.initials: WQ
authors.lastname: Gao
authors.forename: Yang
authors.initials: Y
authors.lastname: Liu
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D045744:Cell Line, Tumor; D003959:Diamines / Q000138:chemical synthesis* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008081:Liposomes; D008175:Lung Neoplasms / Q000188:drug therapy; D010984:Platinum / Q000737:chemistry / Q000494:pharmacology*; D012459:Salicylates; D012995:Solubility; D012997:Solvents; D013057:Spectrum Analysis; D013274:Stomach Neoplasms / Q000188:drug therapy
chemical_list: D000970:Antineoplastic Agents; D003959:Diamines; D008081:Liposomes; D012459:Salicylates; D012997:Solvents; D010984:Platinum