title: (Aryloxyacetylamino)benzoic acid analogues: A new class of hypoxia-inducible factor-1 inhibitors.
abstract: Structural modification of a compound discovered during screening using an HRE-dependent reporter assay has revealed a novel class of HIF-1 inhibitors, which potently inhibit the HIF-1alpha protein accumulation and its target gene expression under hypoxic conditions in human hepatocellular carcinoma Hep3B cells.
authors.affiliation: Molecular Cancer Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea, 305-806.
authors.forename: Kyeong
authors.initials: K
authors.lastname: Lee
authors.forename: Jeong Hyung
authors.initials: JH
authors.lastname: Lee
authors.forename: Shanthaveerappa K
authors.initials: SK
authors.lastname: Boovanahalli
authors.forename: Yinglan
authors.initials: Y
authors.lastname: Jin
authors.forename: Mijeoung
authors.initials: M
authors.lastname: Lee
authors.forename: Xuejun
authors.initials: X
authors.lastname: Jin
authors.forename: Jin Hwan
authors.initials: JH
authors.lastname: Kim
authors.forename: Young-Soo
authors.initials: YS
authors.lastname: Hong
authors.forename: Jung Joon
authors.initials: JJ
authors.lastname: Lee
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D051784:Aryl Hydrocarbon Receptor Nuclear Translocator / Q000037:antagonists & inhibitors; D001565:Benzoates / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D015687:Cell Hypoxia; D045744:Cell Line, Tumor; D004921:Erythropoietin / Q000037:antagonists & inhibitors / Q000235:genetics; D015870:Gene Expression; D006801:Humans; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D012333:RNA, Messenger / Q000037:antagonists & inhibitors; D013329:Structure-Activity Relationship; D042461:Vascular Endothelial Growth Factor A / Q000037:antagonists & inhibitors / Q000235:genetics
chemical_list: C497396:ARNT protein, human; D000970:Antineoplastic Agents; D001565:Benzoates; C497442:HIF1A protein, human; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D012333:RNA, Messenger; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; D004921:Erythropoietin; D051784:Aryl Hydrocarbon Receptor Nuclear Translocator