Interplay of pathogens, cytokines and other stress signals in the regulation of dendritic cell function.
Dendritic cells (DCs) are the only antigen-presenting cell capable of activating naïve T lymphocytes, and hence they play a crucial role in the induction of adaptive immunity. Immature DCs sample and process antigens, and efficiently sense a large variety of signals from the surrounding environment. Upon activation, they become capable to activate naïve T cells and to direct the differentiation and polarization of effector T lymphocytes. It is becoming increasingly clear that different signals are able to determine distinct programs of DC differentiation and different forms of immunity and tolerance. In the past few years many advances have been made in addressing the action exerted by pathogen-associated molecular patterns (PAMPs), cytokines, chemokines, and other less characterized stress molecules on the activity of DCs. In this review we focus on the multiplicity of innate signals able to modulate the functional profile of DCs.
Sabatté
Juan
J
Institute of Haematological Research, National Academy of Medicine and National Reference Centre for AIDS, Department of Microbiology, Buenos Aires University School of Medicine, Buenos Aires, Argentina.
Maggini
Julian
J
Nahmod
Karen
K
Amaral
María M
MM
Martínez
Diego
D
Salamone
Gabriela
G
Ceballos
Ana
A
Giordano
Mirta
M
Vermeulen
Mónica
M
Geffner
Jorge
J
D000818:Animals; D017951:Antigen Presentation / Q000276:immunology*; D002454:Cell Differentiation / Q000276:immunology*; D016207:Cytokines / Q000276:immunology*; D003713:Dendritic Cells / Q000276:immunology*; D006801:Humans; D007108:Immune Tolerance; D007113:Immunity, Innate; D008213:Lymphocyte Activation / Q000276:immunology; D015398:Signal Transduction / Q000276:immunology*; D013312:Stress, Physiological / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
D016207:Cytokines