Propofol modulates inner retina function in Beagles.
OBJECTIVE
To further understand a common veterinary anesthetic, propofol (2,6- di-isopropylphenol) and effects of infusion rates on the retinal neurons in Beagle dogs.


METHODS
Standard full-field blue xenon-flash stimulation elicited responses of dark-adapted eyes, which were recorded from dogs before and after a propofol infusion rate increase.


RESULTS
Electroretinogram b-waves increased significantly after the infusion rate increase and decreased with decline (P < 0.0001). Also, a weak significance (P = 0.041) for a-wave peak amplitude increase was found after infusion rate increase. The initial part (first 18 ms) of the leading edge of the a-wave remained unchanged. No significant differences in times to a- and b-wave peaks were found.


CONCLUSIONS
Enhanced b-wave response and decline is due to sensitivity of postreceptoral cells, possibly interplexiform and amacrine cells, to propofol concentration.
Kommonen
Bertel
B
Section of Surgery, Department of Clinical Veterinary Medicine, University of Helsinki, Finland. kommonen@mappi.helsinki.fi
Hyvätti
Eira
E
Dawson
William W
WW
D000768:Anesthesia, General / Q000662:veterinary*; D018686:Anesthetics, Intravenous / Q000494:pharmacology*; D000818:Animals; D003623:Dark Adaptation; D004285:Dogs / Q000502:physiology*; D004596:Electroretinography / Q000662:veterinary; D005260:Female; D007262:Infusions, Intravenous / Q000662:veterinary; D008297:Male; D010375:Pedigree; D010775:Photic Stimulation; D015742:Propofol / Q000008:administration & dosage / Q000494:pharmacology*; D012160:Retina / Q000187:drug effects*
D018686:Anesthetics, Intravenous; D015742:Propofol