title: Durable neutralizing antibodies after remote smallpox vaccination among adults with and without HIV infection.
abstract: The only US licensed vaccine with established efficacy against smallpox, Dryvax, is contraindicated for HIV patients. Detectable smallpox-neutralizing antibodies are still present among US adults. This study compared vaccinia-neutralizing antibody titers between 20 HIV-infected and 20 uninfected veterans matched for age and military entry. Vaccinia-neutralizing antibodies were detected in 95% HIV-infected and 100% uninfected veterans; 40% HIV-infected and 70% uninfected adults had protective titers. Therefore, after robust vaccination, neutralizing antibodies are maintained for prolonged times despite CD4 cell depletion.
authors.affiliation: Infectious Diseases Section, Veterans Affairs Medical Center, Washington, DC, USA.
authors.forename: Virginia L
authors.initials: VL
authors.lastname: Kan
authors.forename: Jody
authors.initials: J
authors.lastname: Manischewitz
authors.forename: Lisa R
authors.initials: LR
authors.lastname: King
authors.forename: Hana
authors.initials: H
authors.lastname: Golding
mesh_terms: D000328:Adult; D000914:Antibodies, Viral / Q000097:blood*; D018791:CD4 Lymphocyte Count; D005260:Female; D015658:HIV Infections / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D012900:Smallpox Vaccine / Q000276:immunology*; D013997:Time Factors; D014616:Vaccinia virus / Q000276:immunology; D014728:Veterans
chemical_list: D000914:Antibodies, Viral; C078786:DryVax vaccine; D012900:Smallpox Vaccine