title: [Diffuse cutaneous leishmaniasis in a patient with AIDS].
abstract: OBJECTIVE
  A patient with a leishmaniasis-Aids co-infection was presented and discussed..
  
  
  RESULTS
  A 29-year -old soldier, coming from the Province of San José del Guaviare, Colombia, complained of a weight loss of 18 kgs in the previous ten months as well as a two-month-old cutaneous leision. Elisa and Western blot tests were positive for HIV infection. LT CD4 were 92/mm3. He had a generalized erythematous, psoriasiform dermal lesion, which, upon biopsy, revealed an abundance of phagocytosed microorganisms that stained black with Gomory's technique. Disseminated histoplasmosis was diagnosed. The patient received anti-retroviral therapy and itraconazole, without regression of the lesions. Amphotericin B was beneficial but the lesions recurred several months later, more numerous, nodular and with occurrence in the oral mucosa. Nine months after the initial diagnosis additional skin biopsies and review of the previous biopsies established that the patient had diffuse cutaneous leishmaniasis. The leishmania parasite did not grow in culture. Miltefosine produced marked improvement, but the lesions recurred and were cured finally with 52 Glucantime injections administered for two months. Presently, the patient remains in good condition 21 months after diagnosis of leishmaniasis.
  
  
  CONCLUSIONS
  Diffuse cutaneous leishmaniasis may be a common clinical manifestation when leishmaniasis and AIDS co-occur. Its treatment is difficult and must include an antiparasitic drug as well as prophylactic, and anti-retroviral therapy. Leishmania amastigotes typically are not Gomory-positive and can be differentiated from Histoplasma by morphology, immunohistochemistry, culture, antibody-specific response and PCR. The leishmaniasis-AIDS co-infection enhances invasive capacity for both causal microorganisms. Increasing case numbers can be expected in Colombia, due to the high frequency of both diseases.
authors.affiliation: Departamentos de Medicina Interna y Servicio de Dermatología, Hospital Militar Central, Bogotá D.C., Colombia.
authors.forename: Carlos
authors.initials: C
authors.lastname: Pérez
authors.forename: Yoanet
authors.initials: Y
authors.lastname: Solías
authors.forename: Gerzaín
authors.initials: G
authors.lastname: Rodríguez
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D000328:Adult; D044966:Anti-Retroviral Agents / Q000627:therapeutic use; D000981:Antiprotozoal Agents / Q000627:therapeutic use; D006801:Humans; D016774:Leishmaniasis, Diffuse Cutaneous / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D008297:Male; D016896:Treatment Outcome
chemical_list: D044966:Anti-Retroviral Agents; D000981:Antiprotozoal Agents