Reverse gyrase: an insight into the role of DNA-topoisomerases.
Reverse gyrase was discovered more than twenty years ago. Recent biochemical and structural results have greatly enhanced our understanding of their positive supercoiling mechanism. In addition to new biochemical properties, a fine tuning of reverse gyrase regulation in response to DNA damaging agents has been recently described. These data give us a new insight in the cellular role of reverse gyrase. Moreover, it has been proposed that reverse gyrase has been implicated in genome stability.
Nadal
Marc
M
Equipe Virologie Moléculaire et Microbiologie, Laboratoire de Génétique et de Biologie Cellulaire, CNRS UMR 8159, Université de Versailles St-Quentin-en-Yvelines, Bâtiment Buffon, 78 035 Versailles, France. marc.nadal@igmors.u-psud.fr
D004249:DNA Damage; D026942:DNA Topoisomerases / Q000235:genetics / Q000378:metabolism*; D004264:DNA Topoisomerases, Type I / Q000235:genetics / Q000378:metabolism*; D004278:DNA, Superhelical / Q000378:metabolism; D016678:Genome; D007700:Kinetics
D004278:DNA, Superhelical; D026942:DNA Topoisomerases; C041813:DNA reverse gyrase; D004264:DNA Topoisomerases, Type I