Statins enhance circulating vitamin E.
Statins have been shown to inhibit oxidative stress, however it is still unclear if they influence antioxidant status. We performed a retrospective analysis of oxidative stress, as assessed by serum levels of 8-hydroxy-2-deoxyguanosine (8-OHdG) and vitamin E, a known antioxidant, in patients with metabolic syndrome (n=112) treated (n=30) or not (n=82) with statins. Statin-treated patients showed higher levels of vitamin E (p=0.02) and lower 8-OHdG (p<0.01) than statin-free patients. An inverse correlation between oxidative stress and vitamin E was observed (r=-0.670, p<0.001). These preliminary data suggest that statins enhance the antioxidant status likely by inhibiting oxidative stress.
Cangemi
Roberto
R
Loffredo
Lorenzo
L
Carnevale
Roberto
R
Pignatelli
Pasquale
P
Violi
Francesco
F
D000069059:Atorvastatin; D005260:Female; D006538:Heptanoic Acids / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000188:drug therapy; D008875:Middle Aged; D018384:Oxidative Stress / Q000187:drug effects*; D011758:Pyrroles / Q000494:pharmacology* / Q000627:therapeutic use; D012189:Retrospective Studies; D019821:Simvastatin / Q000494:pharmacology* / Q000627:therapeutic use; D014810:Vitamin E / Q000097:blood*
D006538:Heptanoic Acids; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D011758:Pyrroles; D014810:Vitamin E; D000069059:Atorvastatin; D019821:Simvastatin