Histone modifications in response to DNA damage.
The packaging of the eukaryotic genome into highly condensed chromatin makes it inaccessible to the factors required for gene transcription, DNA replication, recombination and repair. Eukaryotes have developed intricate mechanisms to overcome this repressive barrier imposed by chromatin. Histone modifying enzymes and ATP-dependent chromatin remodeling complexes play key roles here as they regulate many nuclear processes by altering the chromatin structure. Significantly, these activities are integral to the process of DNA repair where histone modifications act as signals and landing platforms for various repair proteins. This review summarizes the recent developments in our understanding of histone modifications and their role in the maintenance of genome integrity.
Altaf
Mohammed
M
Laval University Cancer Research Center, Hôtel-Dieu de Québec, Quebec City, Quebec, Canada.
Saksouk
Nehmé
N
Côté
Jacques
J
D000818:Animals; D002843:Chromatin / Q000378:metabolism; D042002:Chromatin Assembly and Disassembly; D002875:Chromosomes / Q000648:ultrastructure; D004249:DNA Damage; D042003:DNA Packaging; D004260:DNA Repair; D004261:DNA Replication; D006657:Histones / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D008958:Models, Molecular; D009707:Nucleosomes; D011499:Protein Processing, Post-Translational; D014158:Transcription, Genetic
D002843:Chromatin; D006657:Histones; D009707:Nucleosomes