title: Influence of the formulation on the tolerance profile of nanoparticle-bound doxorubicin in healthy rats: focus on cardio- and testicular toxicity.
abstract: A toxicological study of doxorubicin bound to poly(butyl cyanoacrylate) or human serum albumin nanoparticles coated with polysorbate 80 was performed in healthy rats. The doxorubicin formulations were injected at a therapeutic dose regimen (3 x 1.5 mg/kg with a 72 h interval), and the animals were followed up for 15 or 30 days. The overall result of this study suggests that the surfactant-coated nanoparticle formulations of doxorubicin have favorable toxicological profiles. Specifically, these formulations display a considerably reduced cardio- and testicular toxicity, as compared to a free drug.
authors.affiliation: Gauze Institute of Novel Antibiotics, Academy of Medical Sciences, Moscow, Russia.
authors.forename: E
authors.initials: E
authors.lastname: Pereverzeva
authors.forename: I
authors.initials: I
authors.lastname: Treschalin
authors.forename: D
authors.initials: D
authors.lastname: Bodyagin
authors.forename: O
authors.initials: O
authors.lastname: Maksimenko
authors.forename: K
authors.initials: K
authors.lastname: Langer
authors.forename: S
authors.initials: S
authors.lastname: Dreis
authors.forename: B
authors.initials: B
authors.lastname: Asmussen
authors.forename: J
authors.initials: J
authors.lastname: Kreuter
authors.forename: S
authors.initials: S
authors.lastname: Gelperina
mesh_terms: D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000737:chemistry / Q000633:toxicity*; D001772:Blood Cell Count; D001835:Body Weight / Q000187:drug effects; D002626:Chemistry, Pharmaceutical; D004317:Doxorubicin / Q000737:chemistry / Q000633:toxicity*; D004337:Drug Carriers; D004339:Drug Compounding; D004659:Enbucrilate / Q000737:chemistry*; D006321:Heart / Q000187:drug effects* / Q000503:physiopathology; D008133:Long QT Syndrome / Q000139:chemically induced; D008297:Male; D009206:Myocardium / Q000473:pathology; D053758:Nanoparticles; D009929:Organ Size / Q000187:drug effects; D011136:Polysorbates / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D012709:Serum Albumin / Q000737:chemistry*; D013501:Surface-Active Agents / Q000737:chemistry; D013610:Tachycardia / Q000139:chemically induced; D013737:Testis / Q000187:drug effects* / Q000473:pathology; D013997:Time Factors
chemical_list: D000903:Antibiotics, Antineoplastic; D004337:Drug Carriers; D011136:Polysorbates; D012709:Serum Albumin; D013501:Surface-Active Agents; D004317:Doxorubicin; D004659:Enbucrilate