title: Blood group AB is associated with increased risk for severe dengue disease in secondary infections.
abstract: Why certain individuals progress to severe dengue disease is unknown. In this study, blood groups associated with dengue disease were investigated. ABO phenotypes were identified by use of serum from 399 patients with dengue-virus infection who participated in a cohort study. ABO blood-group frequencies were similar in primary versus secondary dengue-virus infections. However, in secondary infection, individuals with blood group AB were likely to have dengue hemorrhagic fever grade 3 than either grades 1 and 2 combined (corrected P value, <.0001; odds ratio, 0.097 [95% confidence interval, 0.03-0.33]) or dengue fever (corrected P value, <.0001; odds ratio, 0.119 [95% confidence interval, 0.04-0.37]). To our knowledge, this is the first report demonstrating an association between ABO blood group and the severity of dengue disease.
authors.affiliation: Queen Sirikit National Institute of Child Health, US Army Medical Corps-Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.
authors.forename: Siripen
authors.initials: S
authors.lastname: Kalayanarooj
authors.forename: Robert V
authors.initials: RV
authors.lastname: Gibbons
authors.forename: David
authors.initials: D
authors.lastname: Vaughn
authors.forename: Sharone
authors.initials: S
authors.lastname: Green
authors.forename: Ananda
authors.initials: A
authors.lastname: Nisalak
authors.forename: Richard G
authors.initials: RG
authors.lastname: Jarman
authors.forename: Mammen P
authors.initials: MP
authors.lastname: Mammen
authors.forename: Guey-Chuen
authors.initials: GC
authors.lastname: Perng
mesh_terms: D000017:ABO Blood-Group System; D000914:Antibodies, Viral / Q000032:analysis; D002648:Child; D003715:Dengue / Q000097:blood* / Q000473:pathology; D003716:Dengue Virus / Q000472:pathogenicity*; D004198:Disease Susceptibility; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D010641:Phenotype; D011446:Prospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D015163:Superinfection / Q000097:blood*
chemical_list: D000017:ABO Blood-Group System; D000914:Antibodies, Viral