title: Semiquantitative measurement of drugs in urine samples and measurement of pharmaceutical active substances in serum samples using the Beckman Coulter Synchron LX20 PRO clinical system.
abstract: Our manuscript describes the investigation of options for the detection and semiquantitative assay of drug (metabolites) and the assay of relevant pharmaceutical active substances using the LX20 PRO (Beckman Coulter) in comparison with the Dimension RxL (Dade Behring) and the TDx or AxSYM (Abbott) system. Drug tests carried out with the LX system satisfy sensitivity and selectivity requirements. The assay of the pharmaceutical active substances revealed a few noticeable clusters of values with valproate and, in particular, digitoxin, that can be attributable to the reagents used rather than to the system itself, which is highly stable and reproducible in terms of operation. These values are thus devoid of any considerable clinical significance.
authors.affiliation: Institutfür Laboratoriumsmedizin, HELIOS Kliniken Schwerin, Schwerin, Germany. hkoenig@schwerin.helios-kliniken.de
authors.forename: Harald
authors.initials: H
authors.lastname: König
authors.forename: Heiko-Gundmar
authors.initials: HG
authors.lastname: Lestin
authors.forename: Thomas
authors.initials: T
authors.lastname: Brinkmann
authors.forename: Manfred
authors.initials: M
authors.lastname: Augsten
authors.forename: Bernhard
authors.initials: B
authors.lastname: Kotira
mesh_terms: D001774:Blood Chemical Analysis / Q000295:instrumentation* / Q000379:methods*; D002851:Chromatography, High Pressure Liquid; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D004364:Pharmaceutical Preparations / Q000097:blood* / Q000652:urine*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D004364:Pharmaceutical Preparations