title: Trichlorophenol (TCP) sulfonate esters: a selective alternative to pentafluorophenol (PFP) esters and sulfonyl chlorides for the preparation of sulfonamides.
abstract: 2,4,6-Trichlorophenol (TCP) sulfonate esters undergo effective aminolysis under conventional heating and microwave irradiation; the reactivity of these species is such that chemoselective transformations of PFP sulfonate esters can be achieved.
authors.affiliation: The Christopher Ingold Laboratories, Department of Chemistry, University College London, 20 Gordon Street, London, UKWC1H 0AJ. j.wilden@ucl.ac.uk
authors.forename: Jonathan D
authors.initials: JD
authors.lastname: Wilden
authors.forename: Lynsey
authors.initials: L
authors.lastname: Geldeard
authors.forename: Chieh C
authors.initials: CC
authors.lastname: Lee
authors.forename: Duncan B
authors.initials: DB
authors.lastname: Judd
authors.forename: Stephen
authors.initials: S
authors.lastname: Caddick
mesh_terms: D002733:Chlorophenols / Q000737:chemistry* / Q000378:metabolism; D004952:Esters / Q000138:chemical synthesis* / Q000737:chemistry; D005464:Fluorobenzenes / Q000737:chemistry*; D015394:Molecular Structure; D010636:Phenols / Q000737:chemistry*; D013441:Sulfinic Acids / Q000737:chemistry*; D013449:Sulfonamides / Q000138:chemical synthesis*; D013451:Sulfonic Acids / Q000737:chemistry* / Q000378:metabolism; D005466:Fluorocarbons
chemical_list: D002733:Chlorophenols; D004952:Esters; D005464:Fluorobenzenes; D010636:Phenols; D013441:Sulfinic Acids; D013449:Sulfonamides; D013451:Sulfonic Acids; C044255:sulfonyl chloride; C085539:2,3,4,5,6-pentafluorophenol; D005466:Fluorocarbons; C024564:2,4,6-trichlorophenol