title: [Predictive clinical factors of response to subthalamic nucleus stimulation in Parkinson's disease].
abstract: BACKGROUND
  Subthalamic nucleus stimulation (SNE) is currently a reasonable treatment for patients with advanced Parkinson's disease (PD). Predictive factors for effective SNE have not yet been identified with precision. We have prospectively evaluated response to SNE in a series of patients with advanced PD to study the factors that influence clinical improvement after functional surgery.
  
  
  METHODS
  We prospectively studied 20 patients with advanced PD (age: 59 +/-6.1; stage: 3.0+/-0.8) candidates for SNE. We studied these patients preoperatively and 6 months postoperatively according to Core Assessment Program for Intracerebral Transplantation (CAPIT) protocol including timed tests.
  
  
  CONCLUSIONS
  We found a negative correlation between age and Unified Parkinson Disease Rating Scale (UPDRS) improvement; however, age did not correlate with timed tests improvement. In addition, preoperative severity (UPDRS and Hoehn-Yahr) did not correlate with UPDRS and timed tests improvement. In summary, age is a negative predictor for effective SNE.
authors.affiliation: Servicio de Neurología, Fundación Jiménez Díaz, Madrid, Spain. pgarcia@fjd.es
authors.forename: P J
authors.initials: PJ
authors.lastname: Garcia
authors.forename: J
authors.initials: J
authors.lastname: Muñiz de Igneson
authors.forename: J
authors.initials: J
authors.lastname: Ayerbe
authors.forename: F
authors.initials: F
authors.lastname: Alonso Frech
authors.forename: A
authors.initials: A
authors.lastname: García Torres
authors.forename: A
authors.initials: A
authors.lastname: Contreras
authors.forename: C
authors.initials: C
authors.lastname: Magariños Ascone
mesh_terms: D046690:Deep Brain Stimulation / Q000295:instrumentation / Q000379:methods; D006801:Humans; D008875:Middle Aged; D010300:Parkinson Disease / Q000601:surgery / Q000628:therapy*; D011446:Prospective Studies; D019736:Prostheses and Implants