Oxidative kidney damage in preterm newborns during perinatal period.
BACKGROUND
Oxidative stress has recently been found to play a key role in post-ischemic kidney damage. We tested the hypothesis that oxidative kidney damage due to perinatal hypoxia in preterm newborns is associated with an increased production of oxidative free radicals in plasma.


METHODS
Blood and urine samples were obtained at birth and on days 7 and 14, from 55 preterm newborns, without any known congenital abnormalities. Total hydroperoxides (TH) and advanced oxidation protein products (AOPP) as indices of oxidative stress, xanthine (Xa) and hypoxanthine (Hx) as indices of hypoxia, alpha1-microglobulin and N-acetyl-beta-D-glucosaminidase (NAG) as indices of kidney damage were assayed.


RESULTS
Statistically significant correlations (p<0.05) were found between biochemical markers of hypoxia, oxidative stress and proximal tubules damage at days 7 and 14.


CONCLUSIONS
Perinatal oxidative stress is associated with a variable degree of kidney damage detectable at birth and continuing up to 14 days.
Perrone
Serafina
S
Department of Paediatrics, Obstetrics and Reproductive Medicine, University of Siena, Policlinico Le Scotte, V.le Bracci 36, 53100 Siena, Italy.
Mussap
Michele
M
Longini
Mariangela
M
Fanos
Vassilios
V
Bellieni
Carlo V
CV
Proietti
Fabrizio
F
Cataldi
Luigi
L
Buonocore
Giuseppe
G
D000118:Acetylglucosaminidase / Q000097:blood; D000510:Alpha-Globulins / Q000032:analysis; D005260:Female; D006801:Humans; D006861:Hydrogen Peroxide / Q000097:blood; D019271:Hypoxanthine / Q000097:blood; D000860:Hypoxia / Q000503:physiopathology*; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000209:etiology*; D007674:Kidney Diseases / Q000503:physiopathology*; D008297:Male; D018384:Oxidative Stress; D019820:Xanthine / Q000097:blood
D000510:Alpha-Globulins; C016001:alpha-1-microglobulin; D019820:Xanthine; D019271:Hypoxanthine; D006861:Hydrogen Peroxide; D000118:Acetylglucosaminidase