Treatment of radiation-induced dermatitis with light-emitting diode (LED) photomodulation.
OBJECTIVE
Light-emitting diode (LED) photomodulation increases dermal collagen and reduces inflammation. This study evaluated the use of LED photomodulation in the prevention of radiation-induced dermatitis in breast cancer.


METHODS
Patients (n=19) were treated with LED photomodulation (Gentlewaves, Light BioScience, LLC, Virginia Beach, VA) after each of a series of intensity-modulated radiation treatments (IMRT). Skin reactions were monitored weekly with National Cancer Institute (NCI) criteria. Age-matched controls (n=28) received IMRT without LED photomodulation.


RESULTS
In LED-treated patients, 18 (94.7%) had grade 0 or 1 reaction and 1 (5.3%) had grade 2 reaction. Among controls, 4 (14.3%) had a grade 1 reaction, 24 (85.7%) had a grade 2 or 3 reaction. One LED-treated patient (5.3%) and 19 controls (67.9%) had to interrupt treatment.


CONCLUSIONS
LED photomodulation treatments immediately after IMRT reduces the incidence of NCI grades 1, 2, and 3 skin reactions in patients with breast cancer treated by radiation therapy (RT) postlumpectomy.
DeLand
M Maitland
MM
Oncologics, Inc., and Louisiana State University School of Medicine, Lafayette, Louisiana, USA.
Weiss
Robert A
RA
McDaniel
David H
DH
Geronemus
Roy G
RG
D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000532:radiotherapy*; D005260:Female; D005347:Fibroblasts / Q000528:radiation effects; D006801:Humans; D008875:Middle Aged; D010789:Phototherapy; D011446:Prospective Studies; D011855:Radiodermatitis / Q000517:prevention & control*; D050397:Radiotherapy, Intensity-Modulated / Q000009:adverse effects