title: Natural and synthetic cholera toxin antagonists.
abstract: Cholera Toxin (CT) recognizes the cell membrane through specific interactions with ganglioside GM1. Recent structural elucidation of the CT/GM1 complex has allowed the rational design of artificial receptors for the toxin, which could function as anti-cholera drugs. The efforts towards the rational design of Cholera Toxin inhibitors will be presented.
authors.affiliation: Dipartimento di Biotecnologie e Bioscienze, Università degli Studi di Milano-Bicocca, Piazza della Scienza 2, I-20126 Milan, Italy.
authors.forename: I A
authors.initials: IA
authors.lastname: Velter
authors.forename: M
authors.initials: M
authors.lastname: Politi
authors.forename: C
authors.initials: C
authors.lastname: Podlipnik
authors.forename: F
authors.initials: F
authors.lastname: Nicotra
mesh_terms: D001688:Biological Products / Q000737:chemistry* / Q000494:pharmacology*; D002772:Cholera Toxin / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000378:metabolism; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D008024:Ligands
chemical_list: D001688:Biological Products; D004791:Enzyme Inhibitors; D008024:Ligands; D002772:Cholera Toxin