title: Dysoxylins A-D, tetranortriterpenoids with potent anti-RSV activity from Dysoxylum gaudichaudianum.
abstract: Four new compounds, belonging to the tetranortriterpenoid family, named dysoxylins A-D (1-4), isolated from Dysoxylum gaudichaudianum, were found to exhibit potent antiviral activity against respiratory syncytial virus (RSV). These structures were determined by NMR spectroscopy and mass spectrometry and were shown to have anti-RSV EC50 activities in the range 1.0-4.0 microg/mL in cytopathic effect inhibition and plaque reduction assays.
authors.affiliation: Shaman Pharmaceuticals, South San Francisco, California 94080, USA.
authors.forename: Jian Lu
authors.initials: JL
authors.lastname: Chen
authors.forename: Michael R
authors.initials: MR
authors.lastname: Kernan
authors.forename: Shivanand D
authors.initials: SD
authors.lastname: Jolad
authors.forename: Cheryl A
authors.initials: CA
authors.lastname: Stoddart
authors.forename: Mark
authors.initials: M
authors.lastname: Bogan
authors.forename: Raymond
authors.initials: R
authors.lastname: Cooper
mesh_terms: D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D029582:Meliaceae / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010219:Papua New Guinea; D010946:Plants, Medicinal / Q000737:chemistry*; D012136:Respiratory Syncytial Viruses / Q000187:drug effects*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000998:Antiviral Agents; D014315:Triterpenes