Synthesis and antibacterial activity of levofloxacin derivatives with certain bulky residues on piperazine ring.
A number of levofloxacin analogues carrying a 2-aryl-2-oxoethyl or a 2-aryl-2-oxyiminoethyl moiety attached to the piperazine ring at C-10 position have been prepared and evaluated as antibacterial agents against a series of Gram-positive and Gram-negative bacteria. Some of them exhibited significant inhibitory activity against Gram-positive bacteria.
Foroumadi
Alireza
A
Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran 14174, Iran.
Emami
Saeed
S
Mansouri
Shahla
S
Javidnia
Azita
A
Saeid-Adeli
Nosratollah
N
Shirazi
Farshad H
FH
Shafiee
Abbas
A
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D064704:Levofloxacin; D015394:Molecular Structure; D015242:Ofloxacin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D064704:Levofloxacin; D015242:Ofloxacin