title: Triple-helix mediated excimer and exciplex formation.
abstract: The synthesis and properties of triple-helical hybrids containing non-nucleosidic polyaromatic building blocks are described. Clamp-type oligonucleotides containing a non-nucleosidic pyrene linker form stable triple helices with a polypurine target strand containing a terminal pyrene or phenanthrene moiety. Stacking interactions between the unnatural building blocks enhance triplex stability and lead to strong excimer or exciplex formation, which is monitored by fluorescence spectroscopy.
authors.affiliation: Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, CH-3012 Bern, Switzerland.
authors.forename: Ivan
authors.initials: I
authors.lastname: Trkulja
authors.forename: Robert
authors.initials: R
authors.lastname: Häner
mesh_terms: D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D009841:Oligonucleotides / Q000737:chemistry*; D010616:Phenanthrenes / Q000737:chemistry; D011721:Pyrenes / Q000737:chemistry; D013050:Spectrometry, Fluorescence
chemical_list: D009841:Oligonucleotides; D010616:Phenanthrenes; D011721:Pyrenes; C031181:phenanthrene; C030984:pyrene