Event-related potentials in an emotional go/no-go task and remission of geriatric depression.
Anterior cingulate integrity may be required for antidepressant response. To assess anterior cingulate processes related to treatment response, we studied error-related negativity and error positivity produced during an emotional go/no-go challenge, a task activating the rostral anterior cingulate. Twelve elderly patients with major depression, treated with escitalopram 10 mg daily, were studied. Patients who remained symptomatic after 8 weeks of treatment had larger error-related negativity and smaller error positivity amplitude compared with patients who achieved remission. The error-related negativity is elicited during conflict detection and the error positivity reflects the emotional reaction to error. Thus, these findings suggest that two distinct conflict-processing functions of the anterior cingulate are important for antidepressant response of geriatric depression.
Alexopoulos
George S
GS
Weill Medical College of Cornell University, Weill-Cornell Institute of Geriatric Psychiatry, White Plains, New York 10605, USA. gsalexop@med.cornell.edu
Murphy
Christopher F
CF
Gunning-Dixon
Faith M
FM
Kalayam
Balkrishna
B
Katz
Richard
R
Kanellopoulos
Dora
D
Etwaroo
Glenda R
GR
Klimstra
Sibel
S
Foxe
John J
JJ
D000368:Aged; D000375:Aging / Q000502:physiology*; D000928:Antidepressive Agents / Q000494:pharmacology*; D001931:Brain Mapping; D015283:Citalopram / Q000494:pharmacology; D003657:Decision Making / Q000187:drug effects / Q000502:physiology; D003865:Major Depressive Disorder / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology*; D004569:Electroencephalography / Q000187:drug effects; D004644:Emotions / Q000187:drug effects / Q000502:physiology*; D005071:Evoked Potentials / Q000187:drug effects / Q000502:physiology*; D005260:Female; D006179:Gyrus Cinguli / Q000187:drug effects / Q000503:physiopathology*; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D011237:Predictive Value of Tests; D012074:Remission Induction; D017367:Selective Serotonin Reuptake Inhibitors / Q000494:pharmacology; D016896:Treatment Outcome
D000928:Antidepressive Agents; D015283:Citalopram; D017367:Selective Serotonin Reuptake Inhibitors