title: Secondary metabolites from Andrographis paniculata.
abstract: Two new flavonoid glycosides, 5-hydroxy-7,8-dimethoxy (2R)-flavanone-5-O-beta-D-glucopyranoside (1) and 5-hydroxy-7,8,2',5'-tetramethoxy-flavone-5-O-beta-D-glucopyranoside (2), and a new diterpenoid, andrographic acid (3), along with andrographidine A (4) were isolated from Andrographis paniculata, and their structures were determined on the basis of physicochemical and spectroscopic analysis. Compound 3 was evaluated for cytotoxicity to KB cells along with andrographolide, isoandrographolide, neoandrographolide and 14-deoxy-11,12-didehydroandrographolide obtained from A. paniculata in the present study. Cytotoxicity was observed for andrographolide and isoandrographolide with ED50 values of 6.5 and 5.1 microg/ml, respectively.
authors.affiliation: Department of Medicinal Chemistry and Pharmacognosy (m/c 781), University of Illinois at Chicago, IL 60612, USA.
authors.forename: Wenkui
authors.initials: W
authors.lastname: Li
authors.forename: Xudong
authors.initials: X
authors.lastname: Xu
authors.forename: Hongjie
authors.initials: H
authors.lastname: Zhang
authors.forename: Cuiying
authors.initials: C
authors.lastname: Ma
authors.forename: Harry
authors.initials: H
authors.lastname: Fong
authors.forename: Richard
authors.initials: R
authors.lastname: van Breemen
authors.forename: John
authors.initials: J
authors.lastname: Fitzloff
mesh_terms: D035685:Andrographis / Q000737:chemistry* / Q000378:metabolism*; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy; D004224:Diterpenes / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology*; D006801:Humans; D007624:KB Cells; D015394:Molecular Structure
chemical_list: D000970:Antineoplastic Agents; D004224:Diterpenes