Centromere assembly and propagation.
Centromere assembly provides a unique example of how elaborate protein structures can be assembled onto DNA, independent of sequence, and then stably propagated through numerous cell divisions. Here, we review the possible epigenetic strategies that organisms ranging from yeast to human use to assemble and propagate active centromeres.
Morris
Corey A
CA
Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA. cmorris@hms.harvard.edu
Moazed
Danesh
D
D000818:Animals; D002455:Cell Division / Q000235:genetics*; D002503:Centromere / Q000235:genetics* / Q000378:metabolism; D002843:Chromatin / Q000378:metabolism; D020090:Chromosome Segregation / Q000235:genetics*; D004247:DNA / Q000235:genetics* / Q000378:metabolism; D044127:Epigenesis, Genetic / Q000235:genetics*; D006657:Histones / Q000378:metabolism; D006801:Humans
D002843:Chromatin; D006657:Histones; D004247:DNA