title: Chronic pain and obstetric management of a patient with tuberous sclerosis.
abstract: Chronic nonmalignant pain is very disabling and carries a heavy financial strain on the individual and society as a whole. This case describes a woman with tuberous sclerosis, in her fourth pregnancy. Approximately 18 months prior to pregnancy, intractable left loin pain, thought to be secondary to hemorrhage within a tuberous lesion in the left kidney, had led to the siteing of an intrathecal morphine pump. The risks of system failure (dislodgement, dislocation), escalating dosage, infection, use in labor, and neonatal opioid withdrawal are all explored and discussed. While data are limited, with increasing use of intrathecal opioids for nonmalignant pain, such patients may be seen more regularly in obstetric clinics. With a multidisciplinary team approach, risks can be minimized and outcome for mother and baby optimized.
authors.affiliation: Specialist Registrar Obstetrics and Gynecology, South Manchester University Hospital, Manchester, UK. tahghighibyrd@aol.com
authors.forename: Louise M
authors.initials: LM
authors.lastname: Byrd
authors.forename: B
authors.initials: B
authors.lastname: Jadoon
authors.forename: I
authors.initials: I
authors.lastname: Lieberman
authors.forename: Tracey
authors.initials: T
authors.lastname: Johnston
mesh_terms: D000328:Adult; D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D002908:Chronic Disease; D036861:Delivery, Obstetric; D005260:Female; D006470:Hemorrhage / Q000150:complications / Q000209:etiology; D006801:Humans; D015918:Infusion Pumps, Implantable; D007278:Injections, Spinal; D009020:Morphine / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D010146:Pain / Q000188:drug therapy* / Q000209:etiology*; D011247:Pregnancy; D011537:Pruritus / Q000139:chemically induced / Q000209:etiology; D014402:Tuberous Sclerosis / Q000150:complications*
chemical_list: D000701:Analgesics, Opioid; D009020:Morphine