title: [Gastric relapse of stage I ocular adnexal mucosa-associated lymphoid tissue lymphoma].
abstract: A 57-year-old male with right ocular adnexal mucosa-associated lymphoid tissue lymphoma (MALT lymphoma) was successfully treated with local radiation therapy. The gastroendoscopic examination revealed a slight inflammatory change of the gastric mucosa, and the urease test was positive. Eradication therapy against Helicobacter pylori was successfully done, however, the patient developed gastric MALT lymphoma two years after the initial treatment. Southern blot analysis of the immunoglobulin heavy chain gene rearrangement revealed that the lymphoma cells from the ocular adnexal and gastric MALT lymphomas were identical, indicating that the gastric MALT lymphoma was not the primary but the metastatic region from the ocular adnexal MALT lymphoma. Further, immunohistochemical staining demonstrated the expression of integrin alpha4beta 7 on ocular adnexal MALT lymphoma cells, which is essential for the adhesion of lymphocytes to gastrointestinal mucosa. These results indicate that ocular adnexal MALT lymphoma cells can metastasize to the stomach, depending on the adhesional function of integrin alpha4 beta7.
authors.affiliation: Fourth Department of Internal Medicine, Sapporo Medical University, School of Medicine.
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Sato
authors.forename: Rishu
authors.initials: R
authors.lastname: Takimoto
authors.forename: Satoshi
authors.initials: S
authors.lastname: Iyama
authors.forename: Kaoru
authors.initials: K
authors.lastname: Ono
authors.forename: Shingo
authors.initials: S
authors.lastname: Tanaka
authors.forename: Naoko
authors.initials: N
authors.lastname: Araki
authors.forename: Kiwami
authors.initials: K
authors.lastname: Nishiie
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Murase
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Sato
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Kobune
authors.forename: Takuya
authors.initials: T
authors.lastname: Matsunaga
authors.forename: Junji
authors.initials: J
authors.lastname: Kato
authors.forename: Yoshiro
authors.initials: Y
authors.lastname: Niitsu
mesh_terms: D005134:Eye Neoplasms / Q000473:pathology* / Q000532:radiotherapy; D005773:Gastroscopy; D016481:Helicobacter Infections / Q000188:drug therapy; D016480:Helicobacter pylori; D006801:Humans; D016023:Integrins / Q000096:biosynthesis; D007765:Lacrimal Apparatus; D018442:Lymphoma, B-Cell, Marginal Zone / Q000235:genetics / Q000473:pathology* / Q000532:radiotherapy; D008297:Male; D008875:Middle Aged; D015514:Oncogene Proteins, Fusion / Q000235:genetics*; D013274:Stomach Neoplasms / Q000235:genetics / Q000378:metabolism / Q000556:secondary*
chemical_list: C115494:IgH-MMSET fusion protein, human; D016023:Integrins; D015514:Oncogene Proteins, Fusion; C071777:integrin alpha4beta7