Hyperglycemia promotes microinflammation as evaluated by C-reactive protein in the very elderly.
OBJECTIVE
C-reactive protein (CRP) is not only an acute phase reactant but also a sensitive marker of subclinical inflammation associated with atherosclerosis. The aim of the present study was to determine whether glycemic control or blood pressure influences the vascular microinflammation as evaluated by CRP levels in the very elderly.


METHODS
The study group consisted of 195 residents aged 85 years. The subjects were divided into three groups according to their CRP levels; a low (<1 mg/L), an average (1 to 3 mg/L), and a high (3 to 10 mg/L) CRP group. Hemoglobin A(1c) (HbA(1c)) levels were used as an index of glycemic control.


RESULTS
The HbA(1c) level showed a significant positive correlation with the CRP level (r=0.289, p<0.0001). In contrast, systolic and diastolic blood pressures failed to correlate with the CRP level. The HbA(1c) was significantly greater in the high CRP group compared to the average and the low CRP groups (6.01+/-0.29%, 5.57+/-0.09% and 5.42+/-0.05%, respectively). Furthermore, the HbA(1c) adjusted by sex, body mass index, systolic blood pressure, serum triglyceride and current smoking status was significantly higher in the high CRP group than in the average and the low CRP groups. Multiple regression analysis also revealed that the HbA(1c) level was significantly and independently associated with the CRP level.


CONCLUSIONS
These results suggest that tight good glycemic control, even in very elderly subjects, may be able to reduce the systemic inflammation that contributes to leads to atherosclerosis.
Fukuhara
Masayo
M
Division of General Internal Medicine, Kyushu Dental College, Kitakyushu, Japan.
Matsumura
Kiyoshi
K
Wakisaka
Masanori
M
Takata
Yutaka
Y
Sonoki
Kazuo
K
Fujisawa
Kiyoshi
K
Ansai
Toshihiro
T
Akifusa
Sumio
S
Fujii
Koji
K
Iida
Mitsuo
M
Takehara
Tadamichi
T
D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure; D002097:C-Reactive Protein / Q000032:analysis*; D003971:Diastole; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis*; D006801:Humans; D006943:Hyperglycemia / Q000097:blood / Q000150:complications* / Q000503:physiopathology*; D008297:Male; D012044:Regression Analysis; D013599:Systole; D014657:Vasculitis / Q000097:blood / Q000175:diagnosis* / Q000209:etiology*
D015415:Biomarkers; D002097:C-Reactive Protein; D006442:Glycated Hemoglobin