Tetracycline resistance mediated by tet(W), tet(M), and tet(O) genes of Bifidobacterium isolates from humans.
MICs of tetracyclines were determined for 86 human Bifidobacterium isolates and three environmental strains. The tet(O) gene was found to be absent in these isolates. tet(W) and tet(M) were found in 26 and 7%, respectively, of the Bifidobacterium isolates, and one isolate contained both genes. Chromosomal DNA hybridization showed that there was one chromosomal copy of tet(W) and/or tet(M).
Aires
J
J
EA 4065, Laboratory of Microbiology, Faculté des Sciences Pharmaceutiques et Biologiques, Université Paris Descartes, 4 Avenue de l'Observatoire, Paris, France. julio.aires@univ-paris5.fr
Doucet-Populaire
F
F
Butel
M J
MJ
D001426:Bacterial Proteins / Q000235:genetics*; D039941:Bifidobacteriales Infections / Q000382:microbiology*; D001644:Bifidobacterium / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D002352:Carrier Proteins / Q000235:genetics*; D002876:Chromosomes, Bacterial / Q000235:genetics; D004269:DNA, Bacterial / Q000737:chemistry / Q000235:genetics; D006801:Humans; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D009693:Nucleic Acid Hybridization; D017422:Sequence Analysis, DNA; D013753:Tetracycline Resistance / Q000235:genetics*
D001426:Bacterial Proteins; D002352:Carrier Proteins; D004269:DNA, Bacterial; C083138:Tet M resistance protein, Bacteria; C083139:Tet O resistance protein, Bacteria