Significant linkage to compulsive hoarding on chromosome 14 in families with obsessive-compulsive disorder: results from the OCD Collaborative Genetics Study.
OBJECTIVE
Individuals with obsessive-compulsive disorder (OCD) who have compulsive hoarding behavior are clinically different from other OCD-affected individuals. The objective of this study was to determine whether there are chromosomal regions specifically linked to compulsive hoarding behavior in families with obsessive-compulsive disorder.


METHODS
The authors used multipoint allele-sharing methods to assess for linkage in 219 multiplex OCD families collected as part of the OCD Collaborative Genetics Study. The authors treated compulsive hoarding as the phenotype of interest and also stratified families into those with and without two or more relatives affected with compulsive hoarding.


RESULTS
Using compulsive hoarding as the phenotype, there was suggestive linkage to chromosome 14 at marker D14S588 (Kong and Cox logarithm of the odds ratio [LOD] [KAC(all)=2.9]). In families with two or more hoarding relatives, there was significant linkage of OCD to chromosome 14 at marker C14S1937 (KAC(all)=3.7), whereas in families with fewer than two hoarding relatives, there was suggestive linkage to chromosome 3 at marker D3S2398 (KAC(all)=2.9).


CONCLUSIONS
The findings suggest that a region on chromosome 14 is linked with compulsive hoarding behavior in families with OCD.
Samuels
Jack
J
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, School of Medicine, 600 N. Wolfe St., Meyer 4-181, Baltimore, MD 21287-7228, USA. jacks@jhmi.edu
Shugart
Yin Yao
YY
Grados
Marco A
MA
Willour
Virginia L
VL
Bienvenu
O Joseph
OJ
Greenberg
Benjamin D
BD
Knowles
James A
JA
McCracken
James T
JT
Rauch
Scott L
SL
Murphy
Dennis L
DL
Wang
Ying
Y
Pinto
Anthony
A
Fyer
Abby J
AJ
Piacentini
John
J
Pauls
David L
DL
Cullen
Bernadette
B
Rasmussen
Steven A
SA
Hoehn-Saric
Rudolf
R
Valle
David
D
Liang
Kung-Yee
KY
Riddle
Mark A
MA
Nestadt
Gerald
G
D002874:Chromosome Mapping; D002883:Chromosomes, Human, Pair 14 / Q000235:genetics*; D002893:Chromosomes, Human, Pair 3 / Q000235:genetics; D005190:Family; D005260:Female; D008040:Genetic Linkage / Q000235:genetics*; D005819:Genetic Markers / Q000235:genetics; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009771:Obsessive-Compulsive Disorder / Q000453:epidemiology / Q000235:genetics*; D010375:Pedigree; D010641:Phenotype
D005819:Genetic Markers