Highly enantioselective water-compatible organocatalyst for Michael reaction of ketones to nitroolefins.
A chiral diamine was found to catalyze enantioselective addition of ketones to nitroolefins in aqueous/saline/organic media. The products were obtained with excellent diastereoselectivities (syn/anti = 99:1) and enantioselectivities up to 99%. The reaction could be facilitated using a mild acid. [reaction: see text]
Vishnumaya
Department of Chemistry, Indian Institute of Technology, Kanpur, India-208 016.
Singh
Vinod K
VK