[Long-term efficacy of enlarged thymectomy in treatment of myasthenia gravis and relevant influencing factors: study of 410 cases].
OBJECTIVE
To investigate the long-term efficacy of enlarged thymectomy in treatment of myasthenia gravis (MG) and relevant influencing factors.


METHODS
546 patients with MG underwent enlarged thymectomy and were followed up for 28 months (6 to 85 months). Effective follow-up data were obtained from 410 out of the 546 patients. The clinical data of these 410 patients, 199 males and 211 females, were analyzed.


RESULTS
The remission rate was 42.9% and the effective rate was 82.3%. Multivariate logistic regression analysis revealed that short duration of preoperative period was an independent factor of the surgical curative effect (odds ratio = 0.310, P = 0.006) and sex, age, Osserman classification, pathologic type of thymus seemed to be irrelevant to the surgical curative effect.


CONCLUSIONS
Thymectomy is an effective measure for MG and shows a better prognosis in the patients with shorter illness duration.
Liu
Wei-bin
WB
Department of Neurology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.
Men
Li-na
LN
Chen
Zhen-guang
ZG
Luo
Hong-he
HH
Huang
Ru-xun
RX
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009157:Myasthenia Gravis / Q000601:surgery*; D013934:Thymectomy / Q000379:methods*; D013997:Time Factors; D016896:Treatment Outcome