Association of HLA-DQA1*03011-DQB1*0301 haplotype with the development of respiratory scleroma.
OBJECTIVE
Respiratory scleroma (RS) is a progressive, chronic, granulomatous disease caused by Klebsiella rhinoscleromatis. There is only one report of RS association with HLA-DQ3. In this study, molecular association of HLA class II and RS was determined.


METHODS
Nine RS patients and 163 healthy controls were compared. DQA1, DQB1, and DRB1 loci were typed.


RESULTS
Statistical analysis demonstrated association between DQB1*0301 and susceptibility to RS (P(c) = 0.004). Haplotype analysis showed an association of DQA1*03011-DQB1*0301 (P = 1.21E-19) and DRB1*0407-DQA1*03011-DQB1*0301 (P = 0.0002).


CONCLUSIONS
Results established that DQA1*03011-DQB1*0301 haplotype is a strong risk factor for development of RS.
Sánchez-Marín
Luis Alberto
LA
División clínica de Otorhinolaryngology, Hospital General Dr. Manuel Gea González, SSA, México, DF, México.
Bross-Soriano
Daniel
D
Arrieta
José
J
Kawa-Karasik
Simón
S
Martínez-Vilchis
Víctor
V
Jiménez-Lucio
Rocío
R
Olivo-Díaz
Angélica
A
D000328:Adult; D002874:Chromosome Mapping; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006683:HLA-DQ Antigens / Q000235:genetics*; D059848:HLA-DQ alpha-Chains; D059866:HLA-DQ beta-Chains; D006684:HLA-DR Antigens / Q000235:genetics; D059811:HLA-DRB1 Chains; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D012226:Rhinoscleroma / Q000235:genetics*; D012307:Risk Factors
D006683:HLA-DQ Antigens; D059848:HLA-DQ alpha-Chains; D059866:HLA-DQ beta-Chains; C069050:HLA-DQA1 antigen; C069051:HLA-DQB1 antigen; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains