title: Evidence for association between insulin resistance and premature carotid atherosclerosis in childhood obesity.
abstract: The present study was undertaken to determine the presence and predictors of the subclinical atherosclerosis in obese children. Fifty obese children [mean age: 11.7 +/- 2.5 y, mean body mass index (BMI): 28.2 +/- 4.0 kg/m] and 50 age- and sex-matched healthy nonobese controls (mean age: 11.4 +/- 3.73 y, mean BMI: 17.6 +/- 3.0 kg/m) were enrolled in the present study. Oral glucose tolerance test was performed to all obese subjects. Common carotid artery intima-media thickness (IMT) was measured by high-resolution B-mode ultrasonography. Carotid artery IMT was significantly increased (0.0476 +/- 0.007 versus 0.033 +/- 0.011 cm; p < 0.001) in the obese group. There were significant relations between carotid artery IMT and insulin sensitivity indexes derived from fasting samples (fasting glucose to insulin ratio (FGIR; p = 0.004, r = -0.404), quantitative insulin-sensitivity check index (QUICK-I; p = 0.002, r = -0.401) and homeostasis model assessment of insulin resistance (HOMA-IR; p = 0.034, r = 0.300) in the obese group. In a multivariate regression model, QUICK-I emerged as independent correlates for mean IMT in obese children with the total variance explained being 20.7% (beta = -0.58, p < 0.001). We concluded that insulin resistance is an independent risk factor for increased carotid artery IMT in obese children.
authors.affiliation: Selcuk University, Faculty of Medicine, 42080 Konya, Turkey. meatabek@hotmail.com
authors.forename: Mehmet Emre
authors.initials: ME
authors.lastname: Atabek
authors.forename: Ozgur
authors.initials: O
authors.lastname: Pirgon
authors.forename: Ali Sami
authors.initials: AS
authors.lastname: Kivrak
mesh_terms: D000293:Adolescent; D017668:Age of Onset; D002339:Carotid Arteries / Q000473:pathology; D002340:Carotid Artery Diseases / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology*; D016022:Case-Control Studies; D002648:Child; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance / Q000502:physiology*; D008297:Male; D009765:Obesity / Q000150:complications* / Q000473:pathology / Q000503:physiopathology*; D012307:Risk Factors
chemical_list: D007328:Insulin