Polyene antibiotics from Streptomyces mediocidicus.
Three polyene antibiotics, mediomycins A (1), B (2), and clethramycin (3), were isolated from Streptomyces mediocidicus ATCC23936. Their structures were elucidated through extensive NMR study coupled with chemical reactions and MS/MS fragmentation analysis. All three compounds are linear polyenes consisting of a conjugated oxo-triene group and a hexaene moiety. Compounds 1 and 2 are new polyenes. All three compounds demonstrated a broad spectrum of antifungal activity in vitro.
Cai
Ping
P
Chemical and Pharmaceutical Development, Wyeth Research, 401 N. Middletown Road, Pearl River, New York 10965, USA. caip@wyeth.com
Kong
Fangming
F
Fink
Pamela
P
Ruppen
Mark E
ME
Williamson
R Thomas
RT
Keiko
Tabei
T
D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D005231:Fatty Acids, Unsaturated / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D005658:Fungi / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011090:Polyenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D013302:Streptomyces / Q000737:chemistry*; D013463:Sulfuric Acid Esters / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
D000935:Antifungal Agents; D005231:Fatty Acids, Unsaturated; D011090:Polyenes; D013463:Sulfuric Acid Esters; C478490:clethramycin; C518552:mediomycin A; C518553:mediomycin B