title: Transient splenial lesion of the corpus callosum after acute withdrawal of antiepileptic drug: a case report.
abstract: Transient lesions at the splenium of the corpus callosum (SCC) have been reported after withdrawal of specific antiepileptic drugs (AED), though the pathophysiology of the lesions remains unclear. We examined and treated a schizophrenic patient who developed a transient SCC lesion after withdrawal of the AED, carbamazepine. Interestingly, the SCC lesion was accompanied by the onset of diabetes insipidus, a state of arginine-vasopressin (AVP) insufficiency. Because carbamazepine is shown to potentiate the effect of AVP, our case suggests that an insufficiency of AVP followed by withdrawal of AED could contribute to the pathogenesis of a transient SCC lesion.
authors.affiliation: Department of Neurology, Kohnodai Hospital, National Center of Neurology and Psychiatry, Chiba, Japan.
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Honda
authors.forename: Jin
authors.initials: J
authors.lastname: Nishimiya
authors.forename: Hideki
authors.initials: H
authors.lastname: Sato
authors.forename: Maki
authors.initials: M
authors.lastname: Munakata
authors.forename: Masaki
authors.initials: M
authors.lastname: Kamada
authors.forename: Akihide
authors.initials: A
authors.lastname: Iwamura
authors.forename: Hideaki
authors.initials: H
authors.lastname: Nemoto
authors.forename: Takashi
authors.initials: T
authors.lastname: Sakamoto
authors.forename: Tatsuhiko
authors.initials: T
authors.lastname: Yuasa
mesh_terms: D000208:Acute Disease; D000927:Anticonvulsants / Q000009:adverse effects; D001927:Brain Diseases / Q000139:chemically induced* / Q000175:diagnosis*; D002220:Carbamazepine / Q000009:adverse effects*; D003337:Corpus Callosum / Q000187:drug effects* / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D013375:Substance Withdrawal Syndrome / Q000175:diagnosis*; D013997:Time Factors
chemical_list: D000927:Anticonvulsants; D002220:Carbamazepine