title: Sustained release cyclosporine therapy for bilateral keratoconjunctivitis sicca in a red wolf (Canis rufus).
abstract: A 12-yr-old intact male red wolf (Canis rufus) diagnosed with bilateral idiopathic dry eye was treated with subconjunctival drug delivery implants designed to release therapeutic levels of cyclosporine from 12-24 mo. Normal tear production and corneal health has been maintained, alleviating the need for daily handling of the animal for topical medication.
authors.affiliation: Environmental Medicine Consortium, Department of Clinical Sciences, 4700 Hillsborough Street, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, 27606, USA.
authors.forename: Anne E
authors.initials: AE
authors.lastname: Acton
authors.forename: A Brady
authors.initials: AB
authors.lastname: Beale
authors.forename: Brian C
authors.initials: BC
authors.lastname: Gilger
authors.forename: Michael K
authors.initials: MK
authors.lastname: Stoskopf
mesh_terms: D000818:Animals; D016572:Cyclosporine / Q000627:therapeutic use*; D004343:Drug Implants / Q000627:therapeutic use; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D007638:Keratoconjunctivitis Sicca / Q000188:drug therapy / Q000662:veterinary*; D008297:Male; D016896:Treatment Outcome; D019596:Wolves
chemical_list: D004343:Drug Implants; D007166:Immunosuppressive Agents; D016572:Cyclosporine