Macrophages in rheumatoid arthritis.
In rheumatoid arthritis (RA) tissue macrophages release growth factors, matrix metalloproteinases, cytokines, and chemokines. While in normal joints there is a balance between proinflammatory and anti-inflammatory cytokines, an imbalance between these inducers and inhibitors of inflammation occurs in RA, where macrophages are responsible for inducing inflammation, matrix destruction and angiogenesis.
Maruotti
N
N
University of Foggia Medical School, Foggia, Italy.
Cantatore
F P
FP
Crivellato
E
E
Vacca
A
A
Ribatti
D
D
D000818:Animals; D001172:Arthritis, Rheumatoid / Q000378:metabolism*; D018925:Chemokines / Q000378:metabolism; D016207:Cytokines / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D008264:Macrophages / Q000378:metabolism*; D045726:Metalloproteases / Q000378:metabolism; D009389:Neovascularization, Pathologic / Q000378:metabolism
D018925:Chemokines; D016207:Cytokines; D045726:Metalloproteases