title: Introduction: the contribution of pathology to radiosurgery.
abstract: The term radiosurgery signifies any kind of application of ionizing radiation energy, in experimental biology or clinical medicine, aiming at the precise and complete destruction of chosen target structures containing healthy and/or pathological cells, without significant concomitant or late radiation damage to adjacent tissues. The goal of this study is to explore the short- and long-term pathophysiological effects of high-dose focused irradiation on neural tissue and its pathologies with histological, electron-microscopical tissue culture and biological-biochemical methods. Radiosurgical pathology focuses its scope and microscope on tissue, cellular, genetic and molecular changes in the human organism and experimental animals, or in cell lines and other in vitro experiments, generated by the ionizing radiation delivered from radiosurgical devices.
authors.affiliation: National Institute of Neurosurgery and Department of Neurological Surgery, Semmelweis University, Budapest, Hungary.
authors.forename: György T
authors.initials: GT
authors.lastname: Szeifert
authors.forename: Douglas
authors.initials: D
authors.lastname: Kondziolka
authors.forename: L Dade
authors.initials: LD
authors.lastname: Lunsford
authors.forename: István
authors.initials: I
authors.lastname: Nyáry
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Hanzély
authors.forename: Isabelle
authors.initials: I
authors.lastname: Salmon
authors.forename: Marc
authors.initials: M
authors.lastname: Levivier
mesh_terms: D049668:History, 15th Century; D049669:History, 16th Century; D049670:History, 17th Century; D006801:Humans; D019635:Neurosurgical Procedures / Q000266:history; D010336:Pathology / Q000266:history; D016634:Radiosurgery / Q000266:history / Q000379:methods*