title: [Investigation of general toxic influence of preparation Buta in experiment on rats].
abstract: At the department of urology preparation Buta was created, which contain two active components. It is intended for the injection into the prostate. As a result of influence of electroresectoscope the mentioned preparation is underwent a deep polymerization, causes the embolism of blood vessels and this way can ensure the bloodless operating field and prevention of TUR-syndrome. Up today it was not investigated the general toxicity of this preparation. In order to solve this problem there were performed experiments on twenty white rats divided into two groups. In the I group (10 animals) 20 ml of preparation Buta was injected intramuscularly. In the II (control) group (10 animals) 20 ml of Saline (NaCl 0,9%) solution was injected intramuscularly. The rats were under observation during 2 weeks. General physiological state of animals was estimated according to the Irvin's scheme. After 2 weeks the animals were decapitated. Samples of blood, liver, kidneys suprarenal glands and spleen have been obtained. Their morphological structure were examined under the light microscope "Option". The obtained data testify that even in 100 times more doses then injected into prostate the preparation Buta caused only local necroses, but didn't show any general toxic influence on the organism. The mentioned preparation can be recommended for clinical trial.
authors.forename: G Zh
authors.initials: GZh
authors.lastname: Mamasakhlisi
authors.forename: T I
authors.initials: TI
authors.lastname: Shioshvili
mesh_terms: D000009:Abdominal Muscles; D000818:Animals; D007273:Injections, Intramuscular; D007431:Intraoperative Complications / Q000517:prevention & control*; D007668:Kidney / Q000166:cytology / Q000187:drug effects; D008297:Male; D019106:Postoperative Hemorrhage / Q000517:prevention & control*; D044945:Proanthocyanidins / Q000494:pharmacology* / Q000627:therapeutic use*; D011471:Prostatic Neoplasms / Q000601:surgery*; D051381:Rats
chemical_list: D044945:Proanthocyanidins