title: Spindle and giant cell type undifferentiated carcinoma arising in the common bile duct: a case report.
abstract: We report on a 61-year-old Japanese male with a pedunculated tumor in the common bile duct. The tumor consisted of two types of neoplastic cells. The majority showed atypical spindle- and giant-shaped features and proliferated densely in an inflammatory stroma, revealing a sarcomatous pattern. They expressed vimentin, KL-1, and CAM5.2. The remaining minority showed glandular and tubular features, occupied only less than 5%, located only in the tumor surface, and expressed wide spectrum keratin, KL-1, CAM5.2, epithelial membrane antigen, AE1/AE3, and carcinoembryonic antigen. CD68-positive osteoclast-like giant cells were also observed. Therefore, the patient was diagnosed as having an undifferentiated carcinoma, spindle and giant cell type.
authors.affiliation: Department of Surgery, Mito Saiseikai General Hospital, 3-3-10 Futabadai, Mito, Ibaraki 311-4198, Japan.
authors.forename: Haruna
authors.initials: H
authors.lastname: Oikawa
authors.forename: Kuniyuki
authors.initials: K
authors.lastname: Oka
authors.forename: Shigenori
authors.initials: S
authors.lastname: Nagakura
authors.forename: Masaharu
authors.initials: M
authors.lastname: Fukunaga
authors.forename: Norimasa
authors.initials: N
authors.lastname: Sando
authors.forename: Junya
authors.initials: J
authors.lastname: Kashimura
authors.forename: Hando
authors.initials: H
authors.lastname: Hakozaki
mesh_terms: D015703:Antigens, CD / Q000032:analysis; D015214:Antigens, Differentiation, Myelomonocytic / Q000032:analysis; D015415:Biomarkers / Q000032:analysis; D002272:Carcinoembryonic Antigen / Q000032:analysis; D018286:Carcinoma, Giant Cell / Q000737:chemistry / Q000175:diagnosis / Q000473:pathology*; D002454:Cell Differentiation; D049109:Cell Proliferation; D049448:Cholangiopancreatography, Magnetic Resonance; D003138:Common Bile Duct Neoplasms / Q000737:chemistry / Q000175:diagnosis / Q000473:pathology*; D006801:Humans; D007633:Keratins / Q000032:analysis; D019394:Ki-67 Antigen / Q000032:analysis; D008297:Male; D008875:Middle Aged; D018396:Mucin-1 / Q000032:analysis; D014057:Tomography, X-Ray Computed; D016159:Tumor Suppressor Protein p53 / Q000032:analysis; D014746:Vimentin / Q000032:analysis; D000097382:CD68 Molecule
chemical_list: D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D015415:Biomarkers; D002272:Carcinoembryonic Antigen; D007633:Keratins; D019394:Ki-67 Antigen; D018396:Mucin-1; D016159:Tumor Suppressor Protein p53; D014746:Vimentin; C400901:CAM 5.2 antigen; C067980:CD68 antigen, human; D000097382:CD68 Molecule; C495901:TP53 protein, human