Solid phase synthesis of a prototype of a new class of biomimetic receptors for anionic carbohydrates.
A solid phase synthesis for a new biomimetic receptor was developed. First binding studies show that binds anionic carbohydrates such as glucose-1-phosphate and cAMP with association constants in the lower millimolar range in 20% buffered water in DMSO using both polar and apolar interactions.
Schmuck
Carsten
C
Universität Würzburg, Institut für Organische Chemie, Am Hubland, 97074 Würzburg, Germany. schmuck@chemie.uni-wuerzburg.de
Heller
Maija
M
D000838:Anions / Q000737:chemistry; D001120:Arginine / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000737:chemistry; D040761:Biomimetic Materials / Q000138:chemical synthesis* / Q000737:chemistry; D002241:Carbohydrates / Q000737:chemistry*; D020650:Combinatorial Chemistry Techniques; D018716:Molecular Mimicry; D015394:Molecular Structure; D011485:Protein Binding
D000838:Anions; D002241:Carbohydrates; D001120:Arginine