Decoding dosage compensation.
How the mechanisms of dosage compensation distinguish the sex chromosomes from the autosomes has been something of a mystery. A recent study in Caenorhabditis elegans has identified clusters of two common DNA motifs as a cis-acting code for the recruitment of the DCC, the protein complex that mediates dosage compensation.
Deng
Xinxian
X
Department of Pathology, University of Washington, Seattle, WA 98195, USA.
Disteche
Christine M
CM
D000818:Animals; D001665:Binding Sites / Q000235:genetics; D017173:Caenorhabditis elegans / Q000235:genetics*; D004247:DNA / Q000235:genetics / Q000378:metabolism*; D004303:Dosage Compensation, Genetic / Q000235:genetics / Q000502:physiology*; D046912:Multiprotein Complexes / Q000235:genetics / Q000378:metabolism*; D011485:Protein Binding; D013045:Species Specificity; D014960:X Chromosome / Q000235:genetics*
D046912:Multiprotein Complexes; D004247:DNA