[Spermato- and steroidogenesis in young men treated for non-Hodgkin's and Hodgkin's lymphoma during childhood].
BACKGROUND
Chemo- and radiotherapy induce testicular damage leading to long-time or irreversible infertility.


OBJECTIVE
To investigate testicular function (spermato- and steroidogenesis) in adolescents and young men cured of Hodgkin's lymphoma (HL) and non-Hodgkin's lymphoma (NHL).


METHODS
In thirty one patients cured of HL 5.9 +/-3.3 years ago and sixteen--cured of NHL before 5.44y +/-2.9 and in twenty one healthy men, we measured serum levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH), testosterone using immunoenzymatic methods and inhibin B (RIA method). In ten patients, examination of semen was made.


RESULTS
1. Patients with NHL and HL in clinical stage I and IIb, presented normal values of all analyzed parameters. 2. The treatment for HL in IIb, IIIb, IV clinical stage with increasing number of therapeutic protocols, especially together with radiotherapy, led to gonadal dysfunction (increase of FSH, decrease of inhibin B values). 3. The values of testosterone were normal in all patients, whereas LH was elevated in patients treated for HL (stages IIIb and IV).


CONCLUSIONS
1. Treatment for HL of higher clinical stage leads to gonadal dysfunction, especially of spermatogenesis. 2. The treatment for NHL essentially does not have a gonadotoxic effect. 3. The cryopreservation of sperm before starting the treatment should be especially offered to young men with HL. 4. Overall, attempts must be made to design cytostatics protocols less gonadotoxic than at present.
Krawczuk-Rybak
Maryna
M
Klinika Onkologii Dzieciecej, Samodzielny Publiczny Dzieciecy Szpital Kliniczny, ul. Waszyngtona 17, 15-274 Białystok, Poland. rybak@amb.edu.pl
Solarz
Elzbieta
E
Gadomski
Jan
J
Matysiak
Michał
M
Wołczyński
Sławomir
S
D000293:Adolescent; D000328:Adult; D002648:Child; D003131:Combined Modality Therapy / Q000009:adverse effects*; D004797:Enzyme-Linked Immunosorbent Assay; D005640:Follicle Stimulating Hormone / Q000097:blood; D006065:Gonadotropins, Pituitary / Q000097:blood*; D006689:Hodgkin Disease / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy*; D006801:Humans; D007248:Infertility, Male / Q000209:etiology*; D007986:Luteinizing Hormone / Q000097:blood; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy*; D008297:Male; D009367:Neoplasm Staging; D013091:Spermatogenesis / Q000187:drug effects* / Q000528:radiation effects*; D013733:Testicular Diseases / Q000209:etiology
D006065:Gonadotropins, Pituitary; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone