gp96 leads the way for toll-like receptors.
The role of the gp96 heat-shock protein in regulating Toll-like-receptor expression is incompletely understood. Yang et al. (2007) generated mice with conditional deficiency of gp96 in macrophages and found that this protein is an important chaperone for all Toll-like receptors that have been tested.
Harding
Clifford V
CV
Department of Pathology, Wolstein 5534, Case Western Reserve University, 2103 Cornell Road, Cleveland, OH 44106-7288, USA. cvh3@cwru.edu
D000818:Animals; D006801:Humans; D008264:Macrophages / Q000276:immunology; D008562:Membrane Glycoproteins / Q000276:immunology* / Q000378:metabolism; D051379:Mice; D018448:Models, Immunological; D018832:Molecular Chaperones / Q000276:immunology* / Q000378:metabolism; D051193:Toll-Like Receptors / Q000276:immunology* / Q000378:metabolism
D008562:Membrane Glycoproteins; D018832:Molecular Chaperones; D051193:Toll-Like Receptors; C053387:endoplasmin