title: Exercise-induced hypertension, endothelial dysfunction, and coronary artery disease in a marathon runner.
abstract: Aerobic activity performed on a regular basis is 1 of several lifestyle recommendations endorsed to reduce risk of coronary disease. However, 1 potential concern of arduous aerobic activity is exercise-induced hypertension. This is the first case to our knowledge, of accelerated coronary calcification in an otherwise asymptomatic middle-aged male marathon runner devoid of traditional cardiovascular risk factors. As a consequence of exercise-induced hypertension and associated oxidative stress, improvement of endothelial dysfunction occurred after antioxidant supplementation. In conclusion, vigorous aerobic activity in susceptible individuals may promote oxidative stress and coronary atherosclerosis.
authors.affiliation: Department of Medicine, Duke University School of Medicine, Durham, North Carolina, USA.
authors.forename: Radha
authors.initials: R
authors.lastname: Goel
authors.forename: Farhan
authors.initials: F
authors.lastname: Majeed
authors.forename: Robert
authors.initials: R
authors.lastname: Vogel
authors.forename: Mary C
authors.initials: MC
authors.lastname: Corretti
authors.forename: Matthew
authors.initials: M
authors.lastname: Weir
authors.forename: Charles
authors.initials: C
authors.lastname: Mangano
authors.forename: Charles
authors.initials: C
authors.lastname: White
authors.forename: Gary D
authors.initials: GD
authors.lastname: Plotnick
authors.forename: Michael
authors.initials: M
authors.lastname: Miller
mesh_terms: D003324:Coronary Artery Disease / Q000209:etiology* / Q000503:physiopathology / Q000517:prevention & control; D004730:Endothelium, Vascular / Q000503:physiopathology*; D006801:Humans; D006973:Hypertension / Q000209:etiology* / Q000503:physiopathology / Q000517:prevention & control; D008297:Male; D008875:Middle Aged; D012420:Running / Q000502:physiology*