title: Effect of piroxicam gel for pain control and inflammation in Nd:YAG 1064-nm laser hair removal.
abstract: BACKGROUND
  Laser-assisted hair removal is a variably uncomfortable and painful procedure.
  
  
  OBJECTIVE
  The aim of this study was to investigate the efficacy of piroxicam gel on pain control and subsequent inflammation in Nd:YAG 1064 nm laser hair removal in women volunteers.
  
  
  METHODS
  Fifty women volunteers were enrolled in this prospective, randomised, placebo-controlled study over a 6-month period. Subjects were randomly assigned to receive piroxicam gel as Group P or saline as a control group. Topical analgesic and saline were applied to the treatment sites for 45 minutes. The pain scores (VAS) and side effects were recorded before the hair removal, during the hair removal, at the end of the hair removal, and after 1 hour, 2 hours and 24 hours after the hair removal.
  
  
  RESULTS
  Subject characteristics and treatment settings in Nd:YAG 1064 nm laser were similar in both groups. The pain scores (VAS) were significantly lower in the Group P than those of the control group during the hair removal (p < 0.001). Inflammatory side effects such as erythema, edema, and folliculitis, were more frequent in the control group than those of Group P during the procedure (p < 0.001).
  
  
  CONCLUSIONS
  This study showed that piroxicam gel provided adequate pain relief after Nd:YAG 1064 nm laser hair removal in women volunteers. Piroxicam gel was associated with lesser inflammatory side effects when compared to placebo because of its anti-inflammatory effect after the procedure.
authors.affiliation: Department of Anaesthesiology, Karadeniz Technical University, Trabzon, Turkey.
authors.forename: S
authors.initials: S
authors.lastname: Akinturk
authors.forename: A
authors.initials: A
authors.lastname: Eroglu
mesh_terms: D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D016009:Chi-Square Distribution; D005260:Female; D005782:Gels; D006204:Hair Removal / Q000009:adverse effects* / Q000379:methods*; D006801:Humans; D007249:Inflammation / Q000188:drug therapy; D053685:Laser Therapy; D010146:Pain / Q000517:prevention & control*; D010147:Pain Measurement; D010894:Piroxicam / Q000008:administration & dosage*; D011446:Prospective Studies; D018709:Statistics, Nonparametric; D016896:Treatment Outcome
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D005782:Gels; D010894:Piroxicam