A booster vaccination with Mycobacterium bovis BCG does not increase the protective effect of the vaccine against experimental Mycobacterium ulcerans infection in mice.
Buruli ulcer, caused by Mycobacterium ulcerans, is a necrotizing skin disease emerging particularly in West Africa. M. bovis BCG vaccine offers only short-term protection against experimental footpad infection of C57BL/6 mice with M. ulcerans, and the duration of this protection cannot be prolonged by a booster vaccination.
Tanghe
Audrey
A
Mycobacterial Immunology, WIV-Pasteur Institute Brussels, 642 Engelandstraat, B-1180 Brussels, Belgium.
Adnet
Pierre-Yves
PY
Gartner
Tatiana
T
Huygen
Kris
K
D000818:Animals; D001500:BCG Vaccine / Q000008:administration & dosage* / Q000276:immunology; D004195:Disease Models, Animal; D005528:Foot / Q000382:microbiology; D006801:Humans; D007117:Immunization, Secondary; D051379:Mice; D008810:Mice, Inbred C57BL; D009165:Mycobacterium Infections, Nontuberculous / Q000382:microbiology / Q000401:mortality / Q000517:prevention & control*; D009163:Mycobacterium bovis / Q000276:immunology*; D019911:Mycobacterium ulcerans / Q000472:pathogenicity*
D001500:BCG Vaccine