First epidemiological data from the French Trophoblastic Disease Reference Center.
OBJECTIVE
The objective of the study was to describe women registered at the new French Trophoblastic Disease Reference Center and particularly the rates of gestational trophoblastic neoplasia (GTN) after molar pregnancies.


METHODS
Epidemiological data from a prospective cohort of women registered between November 1999 and November 2004 were analyzed.


RESULTS
Four hundred forty-eight women were registered. The referent pathologist reclassified 32% and 5% of assumed partial mole (PM) and complete mole (CM), respectively. GTN developed in 30 of 212 patients with singleton CM (14%) and in 5 of 108 with singleton PM (5%). Among 131 patients with GTN (35 women followed up after registration for a mole and 96 registered for a GTN), 115 (88%) were low-risk and 16 (12%) were high-risk patients according to 2000 International Federation of Gynecology and Obstetrics (FIGO) scoring system.


CONCLUSIONS
Creation of trophoblastic disease reference centers is desirable to improve treatment of patients. Our results will have to be compared with future publications based on the new 2000 FIGO oncology committee recommendations.
Golfier
François
F
Hospices Civils de Lyon, Hôtel-Dieu, Centre de Référence des Maladies Trophoblastiques, Lyon, France. francois.golfier@chu-lyon.fr
Raudrant
Daniel
D
Frappart
Lucien
L
Mathian
Bruno
B
Guastalla
Jean-Paul
JP
Trillet-Lenoir
Véronique
V
Vaudoyer
Fabien
F
Hajri
Touria
T
Schott
Anne-Marie
AM
D000293:Adolescent; D000328:Adult; D005260:Female; D005602:France; D031901:Gestational Trophoblastic Disease / Q000453:epidemiology / Q000209:etiology; D006782:Hospitals, Special / Q000706:statistics & numerical data*; D006801:Humans; D006828:Hydatidiform Mole / Q000150:complications*; D008875:Middle Aged; D011247:Pregnancy; D011446:Prospective Studies; D014328:Trophoblastic Neoplasms / Q000453:epidemiology*; D014594:Uterine Neoplasms / Q000453:epidemiology*