Asymmetric synthesis of novel alpha-amino acids with beta-branched side chains.
An asymmetric synthesis of alpha-amino acids with novel beta-branched side chains has been implemented. The syntheses feature a p-toluenesulfinylimine induced chiral Strecker approach and were found to be applicable to the introduction of both aliphatic and aromatic beta-branched sidechains for preparation of previously unknown alpha-amino acids.
Zhang
Minsheng
M
Wyeth Research, CN 8000, Princeton, NJ 08543, USA. zhangm8@wyeth.com
Porte
Alex
A
Diamantidis
George
G
Sogi
Kimberly
K
Kubrak
Dennis
D
Resnick
Lynn
L
Mayer
Scott C
SC
Wang
Zheng
Z
Kreft
Anthony F
AF
Harrison
Boyd L
BL
D000596:Amino Acids / Q000138:chemical synthesis* / Q000737:chemistry*; D002625:Chemistry, Organic / Q000379:methods; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D015195:Drug Design; D008956:Models, Chemical; D008968:Molecular Conformation
D000596:Amino Acids