The first topologically controlled synthesis of doubly bridged beta-cyclodextrin dimers.
Reaction 6(A),6(B)-di(O-tosyl)-beta-cyclodextrin with Na(2)S in DMF gave the cis-dimer of beta-cyclodextrin in 21% isolated yield while the trans-dimer was not detected.
Yuan
De-Qi
DQ
Department of Molecular Medicinal Sciences, Graduate School of Biomedical Sciences, Nagasaki University, Bunkyo-machi 1-14, Nagasaki, 852-8521, Japan. deqiyuan@nagasaki-u.ac.jp
Koga
Kazutaka
K
Kouno
Isao
I
Fujioka
Toshihiro
T
Fukudome
Makoto
M
Fujita
Kahee
K
D018360:Crystallography, X-Ray; D007202:Indicators and Reagents; D007536:Isomerism; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013440:Sulfides; D047392:beta-Cyclodextrins / Q000138:chemical synthesis*
D007202:Indicators and Reagents; D013440:Sulfides; D047392:beta-Cyclodextrins; C033479:sodium sulfide