Sézary syndrome treated with narrowband ultraviolet B: time-course measurement of serum levels of CCL17/CCL27.
We describe a patient with Sézary syndrome (SS) who was successfully treated with topical steroid and narrowband UVB. Sézary cells in peripheral blood correlated with severity of skin lesions. In addition, serum levels of CCL17 and CCL27 decreased as disease activity improved. These chemokines may be important for the pathogenesis of SS.
Masui
Y
Y
Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan.
Sugaya
M
M
Kagami
S
S
Fujita
H
H
Yano
S
S
Nagao
M
M
Komine
M
M
Saeki
H
H
Ihn
H
H
Kikuchi
K
K
Tamaki
K
K
D000328:Adult; D054414:Chemokine CCL17; D054425:Chemokine CCL27; D019742:Chemokines, CC / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D012751:Sezary Syndrome / Q000097:blood / Q000628:therapy*; D016896:Treatment Outcome; D014467:Ultraviolet Therapy / Q000379:methods
C106230:CCL17 protein, human; C492276:CCL27 protein, human; D054414:Chemokine CCL17; D054425:Chemokine CCL27; D019742:Chemokines, CC