[Predictive clinical factors of response to subthalamic nucleus stimulation in Parkinson's disease].
BACKGROUND
Subthalamic nucleus stimulation (SNE) is currently a reasonable treatment for patients with advanced Parkinson's disease (PD). Predictive factors for effective SNE have not yet been identified with precision. We have prospectively evaluated response to SNE in a series of patients with advanced PD to study the factors that influence clinical improvement after functional surgery.


METHODS
We prospectively studied 20 patients with advanced PD (age: 59 +/-6.1; stage: 3.0+/-0.8) candidates for SNE. We studied these patients preoperatively and 6 months postoperatively according to Core Assessment Program for Intracerebral Transplantation (CAPIT) protocol including timed tests.


CONCLUSIONS
We found a negative correlation between age and Unified Parkinson Disease Rating Scale (UPDRS) improvement; however, age did not correlate with timed tests improvement. In addition, preoperative severity (UPDRS and Hoehn-Yahr) did not correlate with UPDRS and timed tests improvement. In summary, age is a negative predictor for effective SNE.
Garcia
P J
PJ
Servicio de Neurología, Fundación Jiménez Díaz, Madrid, Spain. pgarcia@fjd.es
Muñiz de Igneson
J
J
Ayerbe
J
J
Alonso Frech
F
F
García Torres
A
A
Contreras
A
A
Magariños Ascone
C
C
D046690:Deep Brain Stimulation / Q000295:instrumentation / Q000379:methods; D006801:Humans; D008875:Middle Aged; D010300:Parkinson Disease / Q000601:surgery / Q000628:therapy*; D011446:Prospective Studies; D019736:Prostheses and Implants