title: Biaxial flexural modulus of antibiotic-impregnated orthopedic bone cement.
abstract: Previously reported antibiotic-impregnated cement strengths have been based on uniaxial and fatigue testing methodologies. These methods may not provide an accurate characterization of bone cement's true load-bearing capacity in total joint replacement (TJR). The present study utilized biaxial testing to report on the properties of antibiotic-impregnated cement. Test groups included: PMMA mixed with Vancomycin, Gentamicin, Tobramycin, or no antibiotic (control). In comparison to the control group, PMMA samples mixed with powdered gentamicin resulted in an increase in the mean elastic modulus by 6.50% versus a drop noted with powdered vancomycin and tobramycin by 2.65 and 1.37% respectively. The mean elastic modulus in samples containing liquid gentamicin dropped by 11.6%. This study supports the continued use of powdered antibiotics when clinically indicated, but suggest caution in the use of liquid gentamicin in TJR.
authors.affiliation: Cambridge Memorial Hospital, Cambridge, Ontario, Canada.
authors.forename: James
authors.initials: J
authors.lastname: Leone
authors.forename: Amy
authors.initials: A
authors.lastname: Johnson
authors.forename: Samir
authors.initials: S
authors.lastname: Ziada
authors.forename: Ata
authors.initials: A
authors.lastname: Hashemi
authors.forename: Anthony
authors.initials: A
authors.lastname: Adili
authors.forename: Justin
authors.initials: J
authors.lastname: de Beer
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry*; D001672:Biocompatible Materials / Q000737:chemistry*; D001843:Bone Cements / Q000737:chemistry*; D004548:Elasticity; D005839:Gentamicins / Q000737:chemistry; D006801:Humans; D008422:Materials Testing; D019904:Polymethyl Methacrylate / Q000737:chemistry*; D013718:Tensile Strength; D014031:Tobramycin / Q000737:chemistry; D014640:Vancomycin / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D001672:Biocompatible Materials; D001843:Bone Cements; D005839:Gentamicins; D014640:Vancomycin; D019904:Polymethyl Methacrylate; D014031:Tobramycin