title: Intracerebral haemorrhage in CADASIL. A case report.
abstract: CADASIL is an autosomal dominant inherited arteriopathy caused by a point mutation in the Notch3 gene. Classically, it is characterised by recurrent ischemic strokes, often resulting in mental decline. Intracerebral haemorrhages in CADASIL have rarely been reported. We describe a young male with a genetically proven CADASIL who developed an intracerebral haemorrhage while on anticoagulant therapy.
authors.affiliation: Department of Neurology, Ghent University Hospital, Ghent, Belgium.
authors.forename: Bart F
authors.initials: BF
authors.lastname: Werbrouck
authors.forename: Jan L
authors.initials: JL
authors.lastname: De Bleecker
mesh_terms: D000925:Anticoagulants / Q000009:adverse effects*; D001921:Brain / Q000098:blood supply / Q000473:pathology / Q000503:physiopathology; D002545:Brain Ischemia / Q000188:drug therapy / Q000209:etiology / Q000517:prevention & control; D046589:CADASIL / Q000150:complications* / Q000188:drug therapy* / Q000503:physiopathology; D002536:Cerebral Arteries / Q000187:drug effects* / Q000473:pathology / Q000503:physiopathology; D002543:Cerebral Hemorrhage / Q000139:chemically induced* / Q000235:genetics* / Q000503:physiopathology; D002544:Cerebral Infarction / Q000188:drug therapy / Q000209:etiology / Q000517:prevention & control; D015140:Dementia, Vascular / Q000209:etiology / Q000503:physiopathology; D006801:Humans; D002546:Ischemic Attack, Transient / Q000188:drug therapy / Q000209:etiology / Q000517:prevention & control; D008279:Magnetic Resonance Imaging; D008297:Male; D008833:Microcirculation / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology; D008875:Middle Aged; D012008:Recurrence; D013995:Time; D014057:Tomography, X-Ray Computed
chemical_list: D000925:Anticoagulants