title: Enantioseparation of 1-phenyl-1-propanol on cellulose-derived chiral stationary phase by supercritical fluid chromatography II. Non-linear isotherm.
abstract: The separation of the enantiomers of 1-phenyl-1-propanol by supercritical fluid chromatography on a chiral stationary phase, which consists of cellulose tris (3,5-dimethylphenylcarbamate) coated on a silica support (Chiralcel-OD), is studied under overloaded, non-linear chromatographic conditions. Pulse experiments are performed at a temperature of 30 degrees C using supercritical CO(2) modified with methanol as a mobile phase. The parameters of the binary Langmuir adsorption isotherm are determined by the inverse method, comparing experimental and simulated peak responses. Isotherm parameters are derived for modifier concentrations between 1 and 5% (w/w) and operating pressures between 125 and 185 bar, and the dependency of the isotherm parameters, namely the Henry constant and the saturation capacity, on operating conditions is investigated.
authors.affiliation: ETH Zurich, Institute of Process Engineering, Sonneggstrasse 3, 8092 Zurich, Switzerland.
authors.forename: Stefan
authors.initials: S
authors.lastname: Ottiger
authors.forename: Johannes
authors.initials: J
authors.lastname: Kluge
authors.forename: Arvind
authors.initials: A
authors.lastname: Rajendran
authors.forename: Marco
authors.initials: M
authors.lastname: Mazzotti
mesh_terms: D000433:1-Propanol / Q000737:chemistry*; D000327:Adsorption; D001592:Benzyl Alcohols / Q000737:chemistry / Q000302:isolation & purification*; D002482:Cellulose / Q000031:analogs & derivatives* / Q000737:chemistry; D002853:Chromatography, Liquid / Q000295:instrumentation / Q000379:methods*; D025924:Chromatography, Supercritical Fluid; D008956:Models, Chemical; D048448:Phenylcarbamates / Q000737:chemistry*; D011134:Polysaccharides; D012822:Silicon Dioxide / Q000737:chemistry; D013056:Spectrophotometry, Ultraviolet; D013237:Stereoisomerism; D013816:Thermodynamics
chemical_list: D001592:Benzyl Alcohols; D048448:Phenylcarbamates; D011134:Polysaccharides; C065943:cellulose tris-3,5-dimethylphenyl-carbamate; D012822:Silicon Dioxide; D002482:Cellulose; C007656:alpha-ethylbenzyl alcohol; D000433:1-Propanol