title: The opioid bowel syndrome: a review of pathophysiology and treatment.
abstract: Opioids are responsible for 25 percent of constipation in terminally ill patients. Patients in pain require prophylaxis to prevent opioid bowel syndrome (OBS). Laxatives are the treatment of choice, but are marginally effective. The development of quaternary opioid receptor antagonists is a step toward target-specific therapy for opioid-induced bowel dysfunction. This review will discuss the pathophysiology and management of OBS.
authors.affiliation: Harry R. Horvitz Center for Palliative Medicine, Taussig Cancer Center, The Cleveland Clinic Foundation, Ohio, USA.
authors.forename: Mellar P
authors.initials: MP
authors.lastname: Davis
mesh_terms: D000701:Analgesics, Opioid / Q000009:adverse effects*; D005767:Gastrointestinal Diseases / Q000139:chemically induced / Q000188:drug therapy* / Q000503:physiopathology*; D006801:Humans; D013577:Syndrome
chemical_list: D000701:Analgesics, Opioid