The leptin connection: regulatory T cells and autoimmunity.
Leptin is a cytokine-like hormone with proinflammatory properties linked to autoimmune diseases. In this issue of Immunity, De Rosa et al. (2007) elucidate an important new role for leptin in the anergy and hyporesponsiveness of regulatory T cells.
Hasenkrug
Kim J
KJ
Laboratory of Persistent Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA. khasenkrug@nih.gov
D000818:Animals; D015551:Autoimmunity; D017635:Clonal Anergy; D006801:Humans; D020738:Leptin / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
D020738:Leptin