[Mechanisms of 232Th effects on Chlorella vulgaris Beljer and modifications of it's toxic effect with caffeine and buthionine sulfoximine].
232Th effects and its modifications with caffeine and D, L-buthionine-(S, R)-sulphoximine in Chlorella vulgaris Beijer cells was studied with use an optical density measure after 24 hours growth. Was shown relationship between concentration and toxic effect that is nonlinear and characterized with three parts different in induced damages level. In the first concentration range (0.001-1.551 micromol/l) chlorella growth parameters don't significantly differ from control ones. In the second one (1.724-3.017 micromol/1) statistically significant increase of optical density is but the effect does not dependent on 232Th concentration. The 232Th concentration (>3.448 micromol/l) increase the monotonous decrease in optical density was observed. The main role in 232Th toxic effect decrease make processes of DNA reparation, but not free radical scavenging with glutathione.
Evseeva
T I
TI
Maĭstrenko
T A
TA
Geras'kin
S A
SA
Belykh
E S
ES
D018533:Biomass; D019328:Buthionine Sulfoximine / Q000494:pharmacology*; D002110:Caffeine / Q000494:pharmacology*; D048408:Chlorella vulgaris / Q000187:drug effects* / Q000502:physiology / Q000528:radiation effects*; D004249:DNA Damage / Q000187:drug effects; D004260:DNA Repair / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004307:Dose-Response Relationship, Radiation; D016166:Free Radical Scavengers / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D013910:Thorium / Q000009:adverse effects*; D013997:Time Factors
D016166:Free Radical Scavengers; D011837:Radiation-Protective Agents; D002110:Caffeine; D019328:Buthionine Sulfoximine; D013910:Thorium; D005978:Glutathione