The effect of Na-glutamate treatment on enzyme- and bioelectric activities in rat brain.
Endogenous and exogenous Na-glutamate (Glu) accumulation in central nervous system (CNS) may be involved in neuronal death, leading to neurodegenerative disorders in humans. This paper describes the effect of in vivo and in vitro Glu treatment on rat bioelectric activity in hypothalamus (HT) and cerebral cortex (C), as well as the measurement of brain enzyme activities involved in the metabolism and transport of Glu in brain cells.Glu may be a key factor in the onset of neuronal cell death by changing the cell energetics, the cellular redox-potential, due to a decreased free radical scavenging capacity.
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C R
CR
University of Medicine and Pharmacy Carol Davila, Eroii Sanitari, Bucharest, Romania.
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A S
AS
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F
F
Botea
S
S
D000818:Animals; D016923:Cell Death / Q000187:drug effects; D002540:Cerebral Cortex / Q000187:drug effects; D007031:Hypothalamus / Q000187:drug effects*; D009474:Neurons / Q000187:drug effects / Q000473:pathology; D010084:Oxidation-Reduction / Q000187:drug effects; D051381:Rats; D012970:Sodium Glutamate / Q000494:pharmacology* / Q000627:therapeutic use*; D005723:gamma-Glutamyltransferase / Q000187:drug effects*
D005723:gamma-Glutamyltransferase; D012970:Sodium Glutamate