Modeling force-velocity relation in skeletal muscle isotonic contraction using an artificial neural network.
The aim of this study is to design an artificial neural network (ANN) to model force-velocity relation in skeletal muscle isotonic contraction. We obtained the data set, including physiological and morphometric parameters, by myography and morphometric measurements on frog gastrocnemius muscle. Then, we designed a multilayer perceptron ANN, the inputs of which are muscle volume, muscle optimum length, tendon length, preload, and afterload. The output of the ANN is contraction velocity. The experimental data were divided randomly into two parts. The first part was used to train the ANN. In order to validate the model, the second part of experimental data, which was not used in training, was employed to the ANN and then, its output was compared with Hill model and the experimental data. The behavior of ANN in high forces was more similar to experimental data, but in low forces the Hill model had better results. Furthermore, extrapolation of ANN performance showed that our model is more or less able to simulate eccentric contraction. Our results indicate that ANNs represent a powerful tool to capture some essential features of muscle isotonic contraction.
Dariani
Sharareh
S
Department of Physiology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Keshavarz
Mansoor
M
Parviz
Mohsen
M
Raoufy
Mohammad Reza
MR
Gharibzadeh
Shahriar
S
D000818:Animals; D001703:Biophysics / Q000379:methods*; D007551:Isotonic Contraction; D019563:Mechanics; D008954:Models, Biological; D008962:Models, Theoretical; D009119:Muscle Contraction; D018482:Muscle, Skeletal / Q000378:metabolism*; D009415:Nerve Net; D011898:Ranidae; D013314:Stress, Mechanical; D049490:Systems Biology