title: Molecular phylogeny of modern coxsackievirus A16.
abstract: A phylogenetic analysis of VP1 and VP4 nucleotide sequences of 52 recent CVA16 strains demonstrated two distinct CVA16 genogroups, A and B, with the prototype strain being the only member of genogroup A. CVA16 G-10, the prototype strain, showed a nucleotide difference of 27.7-30.2% and 19.9-25.2% in VP1 and VP4, respectively, in relation to other CVA16 strains, which formed two separate lineages in genogroup B with nucleotide variation of less than 13.4% and less than 16.3% in VP1 and VP4, respectively. Lineage 1 strains circulating before 2000 were later displaced by lineage 2 strains.
authors.affiliation: Institute of Health and Community Medicine, Universiti Malaysia Sarawak, Sarawak, Malaysia.
authors.forename: D
authors.initials: D
authors.lastname: Perera
authors.forename: M A
authors.initials: MA
authors.lastname: Yusof
authors.forename: Y
authors.initials: Y
authors.lastname: Podin
authors.forename: M H
authors.initials: MH
authors.lastname: Ooi
authors.forename: N T T
authors.initials: NT
authors.lastname: Thao
authors.forename: K K
authors.initials: KK
authors.lastname: Wong
authors.forename: A
authors.initials: A
authors.lastname: Zaki
authors.forename: K B
authors.initials: KB
authors.lastname: Chua
authors.forename: Y A
authors.initials: YA
authors.lastname: Malik
authors.forename: P V
authors.initials: PV
authors.lastname: Tu
authors.forename: N T K
authors.initials: NT
authors.lastname: Tien
authors.forename: P
authors.initials: P
authors.lastname: Puthavathana
authors.forename: P C
authors.initials: PC
authors.lastname: McMinn
authors.forename: M J
authors.initials: MJ
authors.lastname: Cardosa
mesh_terms: D001483:Base Sequence; D036022:Capsid Proteins / Q000235:genetics; D017931:DNA Primers / Q000235:genetics; D004279:DNA, Viral / Q000235:genetics; D029821:Enterovirus A, Human / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D019143:Evolution, Molecular; D006232:Hand, Foot and Mouth Disease / Q000821:virology; D006801:Humans; D008969:Molecular Sequence Data; D010802:Phylogeny; D015678:Viral Structural Proteins / Q000235:genetics
chemical_list: D036022:Capsid Proteins; D017931:DNA Primers; D004279:DNA, Viral; D015678:Viral Structural Proteins