title: Serum resistin is associated with the severity of microangiopathies in type 2 diabetes.
abstract: Resistin, secreted from adipocytes, causes insulin resistance and diabetes in rodents. To determine the relation between serum resistin and diabetic microangiopathies in humans, we analyzed 238 Japanese T2DM subjects. Mean serum resistin was higher in subjects with either advanced retinopathy (preproliferative or proliferative) (P=0.0130), advanced nephropathy (stage III or IV) (P=0.0151), or neuropathy (P=0.0013). Simple regression analysis showed that serum resistin was positively correlated with retinopathy stage (P=0.0212), nephropathy stage (P=0.0052), and neuropathy (P=0.0013). Multiple regression analysis adjusted for age, gender, and BMI, revealed that serum resistin was correlated with retinopathy stage (P=0.0144), nephropathy stage (P=0.0111), and neuropathy (P=0.0053). Serum resistin was positively correlated with the number of advanced microangiopathies, independent of age, gender, BMI, and either the duration of T2DM (P=0.0318) or serum creatinine (P=0.0092). Therefore, serum resistin was positively correlated with the severity of microangiopathies in T2DM.
authors.affiliation: Department of Molecular and Genetic Medicine, Ehime, University Graduate School of Medicine, Toon, Ehime 791-0295, Japan. harosawa@m.ehime-u.ac.jp
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Osawa
authors.forename: Masaaki
authors.initials: M
authors.lastname: Ochi
authors.forename: Kenichi
authors.initials: K
authors.lastname: Kato
authors.forename: Junko
authors.initials: J
authors.lastname: Yamauchi
authors.forename: Wataru
authors.initials: W
authors.lastname: Nishida
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Takata
authors.forename: Ryoichi
authors.initials: R
authors.lastname: Kawamura
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Onuma
authors.forename: Tomomi
authors.initials: T
authors.lastname: Takasuka
authors.forename: Ikki
authors.initials: I
authors.lastname: Shimizu
authors.forename: Yasuhisa
authors.initials: Y
authors.lastname: Fujii
authors.forename: Jun
authors.initials: J
authors.lastname: Ohashi
authors.forename: Hideichi
authors.initials: H
authors.lastname: Makino
mesh_terms: D000368:Aged; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications / Q000503:physiopathology*; D003925:Diabetic Angiopathies / Q000097:blood / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D052243:Resistin / Q000097:blood*; D012720:Severity of Illness Index
chemical_list: D052243:Resistin