title: Acquired fanconi syndrome with osteomalacia secondary to monoclonal gammopathy of undetermined significance.
abstract: A 60-year-old woman was admitted because of multiple bone pain. Examination revealed hypophosphatemic osteomalacia and acquired Fanconi syndrome. Further exploration revealed monoclonal gammopathy of undetermined significance (MGUS) excreting urinary Bence Jones protein (kappa light chain). Renal biopsy showed non-specific tubulointerstitial nephritis, yet neither crystalline inclusions in the cytoplasm of the tubular epithelium nor myeloma casts nor amyloid deposits were found. She was treated with supplementation by phosphate, alkali agents, and vitamin D, and responded well to the treatment symptomatically and biochemically. MGUS was observed without chemotherapy. Myeloma had not developed after 10 months follow-up.
authors.affiliation: Division of Hypertension and Nephrology, National Kyushu Medical Center, Fukuoka, Japan. torten54@crest.ocn.ne.jp
authors.forename: Toru
authors.initials: T
authors.lastname: Hashimoto
authors.forename: Kimika
authors.initials: K
authors.lastname: Arakawa
authors.forename: Yuko
authors.initials: Y
authors.lastname: Ohta
authors.forename: Takaichi
authors.initials: T
authors.lastname: Suehiro
authors.forename: Noriko
authors.initials: N
authors.lastname: Uesugi
authors.forename: Masaru
authors.initials: M
authors.lastname: Nakayama
authors.forename: Takuya
authors.initials: T
authors.lastname: Tsuchihashi
mesh_terms: D000468:Alkalies / Q000627:therapeutic use; D001536:Bence Jones Protein / Q000652:urine; D004359:Drug Therapy, Combination; D005198:Fanconi Syndrome / Q000188:drug therapy / Q000209:etiology*; D005260:Female; D006801:Humans; D007145:Immunoglobulin kappa-Chains / Q000652:urine; D007668:Kidney / Q000473:pathology; D008875:Middle Aged; D009395:Nephritis, Interstitial / Q000209:etiology / Q000473:pathology; D010018:Osteomalacia / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000209:etiology*; D010265:Paraproteinemias / Q000150:complications* / Q000652:urine; D010710:Phosphates / Q000627:therapeutic use; D011859:Radiography; D011877:Radionuclide Imaging; D013978:Tibial Fractures / Q000000981:diagnostic imaging / Q000209:etiology; D014807:Vitamin D / Q000627:therapeutic use
chemical_list: D000468:Alkalies; D007145:Immunoglobulin kappa-Chains; D010710:Phosphates; D014807:Vitamin D; D001536:Bence Jones Protein