Synthesis and in vitro cytotoxicity of novel lipophilic (diamine)platinum(II) complexes of salicylate derivatives.
Novel lipophilic (diamine)platinum(II) complexes of salicylate derivatives as the leaving groups were synthesized and characterized by elemental analysis, FAB(+)-MS, FT-IR, and (1)H NMR spectroscopy. Most of the resulting platinum complexes had high solubility in organic solvents such as ethanol, acetone, and ether, and had right partition coefficient suited to be encapsulated in liposomes. The pertinent complexes were evaluated for their in vitro cytotoxicity against A549 human lung carcinoma and SGC-7901 human gastric carcinoma cell lines. They showed better cytotoxic activity than carboplatin and oxaliplatin.
Ye
Qing-Song
QS
Platinum-Based Drug Lab, Kunming Institute of Precious Metals, Kunming 650021, China.
Lou
Li-Guang
LG
Liu
Wei-Ping
WP
Yu
Yao
Y
Chen
Xi-Zhu
XZ
Hou
Shu-Qian
SQ
Gao
Wen-Qui
WQ
Liu
Yang
Y
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D045744:Cell Line, Tumor; D003959:Diamines / Q000138:chemical synthesis* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008081:Liposomes; D008175:Lung Neoplasms / Q000188:drug therapy; D010984:Platinum / Q000737:chemistry / Q000494:pharmacology*; D012459:Salicylates; D012995:Solubility; D012997:Solvents; D013057:Spectrum Analysis; D013274:Stomach Neoplasms / Q000188:drug therapy
D000970:Antineoplastic Agents; D003959:Diamines; D008081:Liposomes; D012459:Salicylates; D012997:Solvents; D010984:Platinum