Asymmetric synthesis of highly substituted gamma-amino acids from allyltitanium sulfoximines.
[structure: see text]. Asymmetric syntheses of the highly substituted protected gamma-amino acids 10a, 10b, 18, and 21 have been developed starting from the allyltitanium sulfoximines V and VI, respectively, and furan-2-carbaldehyde.
Köhler
Franz
F
Institut für Organische Chemie der Rheinisch-Westfälischen Technischen Hochschule Aachen, Landoltweg 1, D-52056 Aachen, Germany.
Gais
Hans-Joachim
HJ
Raabe
Gerhard
G
D000498:Allyl Compounds / Q000737:chemistry*; D000596:Amino Acids / Q000138:chemical synthesis* / Q000737:chemistry; D003500:Cyclization; D007097:Imines / Q000737:chemistry*; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D013237:Stereoisomerism; D013454:Sulfoxides / Q000737:chemistry*; D014025:Titanium / Q000737:chemistry*
D000498:Allyl Compounds; D000596:Amino Acids; D007097:Imines; D009942:Organometallic Compounds; D013454:Sulfoxides; D014025:Titanium