[Ca2+]i signalling in sperm--making the most of what you've got.
Thanks to a worrying decrease in male fertility, understanding how sperm 'work' is a matter both of interest and great importance. Sperm of all animals detect various environmental cues. The 'behavioural' and physiological responses of sperm must be specific, appropriate and correctly timed. Strangely, in a cell with few organelles and minimal cytoplasmic volume, internal Ca(2+) concentration, [Ca(2+)](i), regulates almost all these activities. How does such a simple cell achieve this - and is it as simple as it seems?
Publicover
Stephen
S
Stephen Publicover is in the School of Biosciences, University of Birmingham, Birmingham, B15 2TT, UK. s.j.publicover@bham.ac.uk
Harper
Claire V
CV
Barratt
Christopher
C
D000177:Acrosome / Q000502:physiology; D000818:Animals; D002118:Calcium / Q000378:metabolism; D020013:Calcium Signaling / Q000502:physiology*; D006801:Humans; D008297:Male; D008954:Models, Biological; D013081:Sperm Motility / Q000502:physiology; D013082:Sperm Tail / Q000502:physiology; D013094:Spermatozoa / Q000502:physiology*
D002118:Calcium