title: Thrombotic thrombocytopenic purpura in advanced prostate cancer: case report and published work review.
abstract: Thrombotic thrombocytopenic purpura (TTP) is a generalized disorder of the microcirculation characterized by microangiopathic hemolytic anemia (MHA), thrombocytopenic purpura and systemic microvascular thrombi. TTP has been previously described in two patients with prostate cancer (PC). We report a third case of TTP in a 61-year-old man with hormone-refractory bone metastatic PC. The syndrome presented with confusion, anuric acute renal failure, thrombocytopenia and MHA. A satisfactory recovery was achieved after plasma exchange (PE). TTP should be included in the coagulation disorders occurring in PC patients. Early treatment with plasma exchange is recommended in these particular cases.
authors.affiliation: Internal Medicine, Department of Clinical and Biological Sciences, University of Turin, San Luigi Hospitals, Orbassano, Turin, Italy. cara.vale@tin.it
authors.forename: Valeria
authors.initials: V
authors.lastname: Caramello
authors.forename: Andrea
authors.initials: A
authors.lastname: Dovio
authors.forename: Pasquale
authors.initials: P
authors.lastname: Caraci
authors.forename: Alfredo
authors.initials: A
authors.lastname: Berruti
authors.forename: Alberto
authors.initials: A
authors.lastname: Angeli
mesh_terms: D018450:Disease Progression; D006801:Humans; D008297:Male; D008875:Middle Aged; D011471:Prostatic Neoplasms / Q000150:complications* / Q000473:pathology; D011697:Purpura, Thrombotic Thrombocytopenic / Q000150:complications*