title: Significant linkage to compulsive hoarding on chromosome 14 in families with obsessive-compulsive disorder: results from the OCD Collaborative Genetics Study.
abstract: OBJECTIVE
  Individuals with obsessive-compulsive disorder (OCD) who have compulsive hoarding behavior are clinically different from other OCD-affected individuals. The objective of this study was to determine whether there are chromosomal regions specifically linked to compulsive hoarding behavior in families with obsessive-compulsive disorder.
  
  
  METHODS
  The authors used multipoint allele-sharing methods to assess for linkage in 219 multiplex OCD families collected as part of the OCD Collaborative Genetics Study. The authors treated compulsive hoarding as the phenotype of interest and also stratified families into those with and without two or more relatives affected with compulsive hoarding.
  
  
  RESULTS
  Using compulsive hoarding as the phenotype, there was suggestive linkage to chromosome 14 at marker D14S588 (Kong and Cox logarithm of the odds ratio [LOD] [KAC(all)=2.9]). In families with two or more hoarding relatives, there was significant linkage of OCD to chromosome 14 at marker C14S1937 (KAC(all)=3.7), whereas in families with fewer than two hoarding relatives, there was suggestive linkage to chromosome 3 at marker D3S2398 (KAC(all)=2.9).
  
  
  CONCLUSIONS
  The findings suggest that a region on chromosome 14 is linked with compulsive hoarding behavior in families with OCD.
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, School of Medicine, 600 N. Wolfe St., Meyer 4-181, Baltimore, MD 21287-7228, USA. jacks@jhmi.edu
authors.forename: Jack
authors.initials: J
authors.lastname: Samuels
authors.forename: Yin Yao
authors.initials: YY
authors.lastname: Shugart
authors.forename: Marco A
authors.initials: MA
authors.lastname: Grados
authors.forename: Virginia L
authors.initials: VL
authors.lastname: Willour
authors.forename: O Joseph
authors.initials: OJ
authors.lastname: Bienvenu
authors.forename: Benjamin D
authors.initials: BD
authors.lastname: Greenberg
authors.forename: James A
authors.initials: JA
authors.lastname: Knowles
authors.forename: James T
authors.initials: JT
authors.lastname: McCracken
authors.forename: Scott L
authors.initials: SL
authors.lastname: Rauch
authors.forename: Dennis L
authors.initials: DL
authors.lastname: Murphy
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.forename: Anthony
authors.initials: A
authors.lastname: Pinto
authors.forename: Abby J
authors.initials: AJ
authors.lastname: Fyer
authors.forename: John
authors.initials: J
authors.lastname: Piacentini
authors.forename: David L
authors.initials: DL
authors.lastname: Pauls
authors.forename: Bernadette
authors.initials: B
authors.lastname: Cullen
authors.forename: Steven A
authors.initials: SA
authors.lastname: Rasmussen
authors.forename: Rudolf
authors.initials: R
authors.lastname: Hoehn-Saric
authors.forename: David
authors.initials: D
authors.lastname: Valle
authors.forename: Kung-Yee
authors.initials: KY
authors.lastname: Liang
authors.forename: Mark A
authors.initials: MA
authors.lastname: Riddle
authors.forename: Gerald
authors.initials: G
authors.lastname: Nestadt
mesh_terms: D002874:Chromosome Mapping; D002883:Chromosomes, Human, Pair 14 / Q000235:genetics*; D002893:Chromosomes, Human, Pair 3 / Q000235:genetics; D005190:Family; D005260:Female; D008040:Genetic Linkage / Q000235:genetics*; D005819:Genetic Markers / Q000235:genetics; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009771:Obsessive-Compulsive Disorder / Q000453:epidemiology / Q000235:genetics*; D010375:Pedigree; D010641:Phenotype
chemical_list: D005819:Genetic Markers