Synthesis of a fluorescence-labeled K30 antigen repeating unit using click chemistry.
An N-dansyl-labeled K30 antigen repeating unit, [4-[5-(N,N'-dimethylamino)naphthalene-1-sulfonamine]-1H-1,2,3-triazol-1-yl]hexyl beta-D-glucopyranosyluronate-(1-->3)-alpha-D-galactopyranosyl-alpha-D-mannopyranosyl-(1-->3)-beta-D-galactopyranoside, was synthesized using click chemistry, the copper(I)-catalyzed 1,3-dipolar cycloaddition reaction of an azide and an alkyne. The target compound could further facilitate the studies of interactions among K30 oligosaccharides and proteins.
Cheng
Lijian
L
The State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.
Chen
Qi
Q
Liu
Jun
J
Du
Yuguo
Y
D000942:Antigens, Bacterial / Q000737:chemistry*; D000954:Antigens, Surface / Q000737:chemistry*; D001386:Azides / Q000737:chemistry; D002240:Carbohydrate Sequence; D002384:Catalysis; D003300:Copper / Q000737:chemistry; D005453:Fluorescence; D006031:Glycosylation; D009844:Oligosaccharides / Q000138:chemical synthesis* / Q000378:metabolism
D000942:Antigens, Bacterial; D000954:Antigens, Surface; D001386:Azides; C030659:K antigens; D009844:Oligosaccharides; D003300:Copper