title: Myeloperoxidase G-463A polymorphism and lung cancer: a HuGE genetic susceptibility to environmental carcinogens pooled analysis.
abstract: Myeloperoxidase is a phase I metabolic enzyme that converts the metabolites of benzo[a]pyrene from tobacco smoke into highly reactive epoxides. A polymorphism in the promoter region of myeloperoxidase (463G-->A) has been found to be inversely associated with lung cancer; differences in the association with age and gender have been suggested. We conducted a pooled analysis of individual data from 10 studies (3688 cases and 3874 controls) from the Genetic Susceptibility to Environmental Carcinogens database. The odds ratio for lung cancer was 0.88 (95% confidence interval: 0.80-0.97) for the AG variant of myeloperoxidase G-463A polymorphism, and 0.71 (95% confidence interval: 0.57-0.88) for the AA variant after adjusting for smoking, age, gender, and ethnicity. The inverse association between lung cancer and myeloperoxidase G-463A polymorphism was equally found in males and females (odds ratio for the AA genotype 0.73 [95% confidence interval: 0.56-0.96] and 0.67 [95% confidence interval: 0.46-0.98], respectively), without differences in the association according to age in the two genders. The myeloperoxidase G-463A polymorphism was significantly protective in "ever" smokers but not in "never" smokers. Myeloperoxidase is a key enzyme in tobacco-induced carcinogenesis.
authors.affiliation: University of Pittsburgh, Cancer Institute, Pittsburgh, Pensylvania 15232, USA.
authors.forename: Emanuela
authors.initials: E
authors.lastname: Taioli
authors.forename: Simone
authors.initials: S
authors.lastname: Benhamou
authors.forename: Christine
authors.initials: C
authors.lastname: Bouchardy
authors.forename: Ingolf
authors.initials: I
authors.lastname: Cascorbi
authors.forename: Nohelia
authors.initials: N
authors.lastname: Cajas-Salazar
authors.forename: Heike
authors.initials: H
authors.lastname: Dally
authors.forename: Kwun M
authors.initials: KM
authors.lastname: Fong
authors.forename: Jill E
authors.initials: JE
authors.lastname: Larsen
authors.forename: Loic
authors.initials: L
authors.lastname: Le Marchand
authors.forename: Stephanie J
authors.initials: SJ
authors.lastname: London
authors.forename: Angela
authors.initials: A
authors.lastname: Risch
authors.forename: Margaret R
authors.initials: MR
authors.lastname: Spitz
authors.forename: Isabelle
authors.initials: I
authors.lastname: Stucker
authors.forename: Brian
authors.initials: B
authors.lastname: Weinshenker
authors.forename: Xifeng
authors.initials: X
authors.lastname: Wu
authors.forename: Ping
authors.initials: P
authors.lastname: Yang
mesh_terms: D000367:Age Factors; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics*; D016017:Odds Ratio; D009195:Peroxidase / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011401:Promoter Regions, Genetic / Q000235:genetics*; D012737:Sex Factors; D012907:Smoking / Q000009:adverse effects
chemical_list: D009195:Peroxidase