title: Comparative efficacy of different anthelmintics against fenbendazole-resistant nematodes of pashmina goats.
abstract: A trial using albendazole, albendazole plus rafoxanide combination, ivermectin and doramectin was conducted in Pashmina goats having history of fenbendazole resistance to Haemonchus spp. and maintained at high altitude (>2350 m above sea level). Day 0 infection level was variable in different groups of animals and their larval cultures indicated Haemonchus, Trichostrongylus, Ostertagia and Oesophagostomum spp. infection, in addition to Nematodirus spp. as observed in egg counts. Efficacy of drugs was calculated on day 14 post treatment by faecal egg count reduction test (FECRT). Albendazole was least effective (14%) followed by its combination with rafoxanide (54%). However, ivermectin and doramectin were 96% and 94% effective against gastrointestinal nematodes of Pashmina goats. It was concluded that use of albendazole and its combination with rafoxanide are ineffective in controlling the nematodes of goats at this farm; hence, future use must be avoided. However, regular monitoring of the efficacy of ivermectin and doramectin is needed.
authors.affiliation: Temperate Animal Husbandry Division, Indian Veterinary Research Institute, Nainital, Uttaranchal, India. hiraivri@email2me.net
authors.forename: H
authors.initials: H
authors.lastname: Ram
authors.forename: T J
authors.initials: TJ
authors.lastname: Rasool
authors.forename: A K
authors.initials: AK
authors.lastname: Sharma
authors.forename: H R
authors.initials: HR
authors.lastname: Meena
authors.forename: S K
authors.initials: SK
authors.lastname: Singh
mesh_terms: D015766:Albendazole / Q000627:therapeutic use; D000818:Animals; D000969:Antinematodal Agents / Q000627:therapeutic use*; D004351:Drug Resistance; D005243:Feces / Q000469:parasitology; D005273:Fenbendazole / Q000494:pharmacology; D005767:Gastrointestinal Diseases / Q000188:drug therapy / Q000469:parasitology / Q000662:veterinary*; D015511:Goat Diseases / Q000188:drug therapy* / Q000469:parasitology*; D006041:Goats; D007559:Ivermectin / Q000031:analogs & derivatives / Q000627:therapeutic use; D009348:Nematoda / Q000254:growth & development*; D009349:Nematode Infections / Q000188:drug therapy / Q000469:parasitology / Q000662:veterinary*; D010270:Parasite Egg Count / Q000662:veterinary; D011888:Rafoxanide / Q000627:therapeutic use
chemical_list: D000969:Antinematodal Agents; D011888:Rafoxanide; D005273:Fenbendazole; D007559:Ivermectin; D015766:Albendazole; C084101:doramectin