title: Clinical variables related with in-stent restenosis late regression after bare metal coronary stenting.
abstract: In-stent restenosis (ISR) has an incidence between 20% and 30% using bare metal stents. ISR late regression phenomenon (ISRLR) has been previously described, but clinical variables related with this phenomenon remain unclear. The aim of the study was to identify the variables related with ISRLR.
  
  
  METHODS
  We identified from our data base 30 patients between November 1995 and September 2002 that fulfilled the following criteria: 1) Documented ISR at follow-up angiography (CA-1); 2) treated medically; and 3) Referred for a second follow-up angiography (CA-2). at least 3 months after CA-1. ISRLR was defined as a > 0.2 mm increase in MLD between CA-1 and CA-2, calculated as the 2-fold of our inter-observer variability. ISR late progression was defined as a > 0.2 mm decrease in minimum lumen diameter (MLD) between CA-1 and CA-2.
  
  
  RESULTS
  At the time of CA-2 only 2 patients (6.7%) had symptoms related with the previously stented vessel. We found a mean MLD of 1.03+/-0.34 mm and 1.54+/-0.48 mm at CA-1 and CA-2 respectively (AMLD = 0.51 +/-0.34 mm; p < 0.001). Twenty four patients (80.0%) had ISRLR. Two variables were related to the presence or absence ISRLR: Current smoking at the time of coronary stenting (70.8% vs 20.0% respectively, p = 0.026) and acute coronary syndrome as clinical indication for coronary stenting (and 83.5% vs 40.0% respectively, p = 0.029).
  
  
  CONCLUSIONS
  ISRLR is a frequent phenomenon in patients with ISR treated medically, probably contributing to the benign long-term clinical outcome that has been previously described in patients with asymptomatic or mildly symptomatic ISR. Current smoking at the time of coronary stenting and acute coronary syndrome as clinical indication for coronary stenting are associated with this phenomenon.
authors.affiliation: Division of Interventional Cardiology, Cardiovascular Institute, Hospital Clínico San Carlos, Madrid, Spain. chovei@lycos.com
authors.forename: Alejandro
authors.initials: A
authors.lastname: Alcocer
authors.forename: Raúl
authors.initials: R
authors.lastname: Moreno
authors.forename: Rosana
authors.initials: R
authors.lastname: Hernández
authors.forename: María-José
authors.initials: MJ
authors.lastname: Pérez-Vizcayno
authors.forename: César
authors.initials: C
authors.lastname: Conde
authors.forename: Fernando
authors.initials: F
authors.lastname: Alfonso
authors.forename: Manel
authors.initials: M
authors.lastname: Sabaté
authors.forename: Javier
authors.initials: J
authors.lastname: Escaned
authors.forename: Camino
authors.initials: C
authors.lastname: Bañuelos
authors.forename: Luis
authors.initials: L
authors.lastname: Azcona
authors.forename: Carlos
authors.initials: C
authors.lastname: Macaya
mesh_terms: D000368:Aged; D015906:Angioplasty, Balloon, Coronary / Q000379:methods*; D006328:Cardiac Catheterization; D017023:Coronary Angiography; D003327:Coronary Disease / Q000628:therapy; D023903:Coronary Restenosis / Q000175:diagnosis* / Q000000981:diagnostic imaging; D003627:Data Interpretation, Statistical; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008670:Metals; D008875:Middle Aged; D018579:Patient Selection; D011379:Prognosis; D012907:Smoking; D015607:Stents; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D008670:Metals