Overview of the molecular carcinogenesis of mouse lung tumor models of human lung cancer.
Lung cancer is the leading cause of cancer death worldwide, and the need to develop better diagnostic techniques and therapies is urgent. Mouse models have been utilized for studying carcinogenesis of human lung cancers, and many of the major genetic alterations detected in human lung cancers have also been identified in mouse lung tumors. The importance of mouse models for understanding human lung carcinogenic processes and in developing early diagnostic techniques, preventive measures and therapies cannot be overstated. In this report, the major known molecular alterations in lung tumorigenesis of mice are reviewed and compared to those in humans.
Wakamatsu
Nobuko
N
Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.
Devereux
Theodora R
TR
Hong
Hue-Hua L
HH
Sills
Robert C
RC
D000230:Adenocarcinoma / Q000175:diagnosis / Q000235:genetics*; D000818:Animals; D004195:Disease Models, Animal; D042241:Early Diagnosis; D015972:Gene Expression Regulation, Neoplastic; D011905:Genes, ras / Q000235:genetics; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis / Q000235:genetics*; D051379:Mice; D009154:Mutation; D013045:Species Specificity; D016159:Tumor Suppressor Protein p53 / Q000235:genetics
D016159:Tumor Suppressor Protein p53