title: Effect of taurine on endotoxin-induced alterations in plasma asymmetric dimethylarginine, L-arginine and nitric oxide in guinea pigs.
abstract: The effect of taurine on the plasma levels of L-arginine, asymmetrical dimethylarginine (ADMA) and L-arginine/ADMA ratio and nitric oxide was investigated in experimental endotoxemia. L-arginine and ADMA levels were quantified by high performance liquid chromatography with fluorescence detector. Nitric oxide level was measured with spectrophotometric method. All experiments were performed with four groups (control, taurine, endotoxemia, taurine plus endotoxin) of 10 guinea pigs. After the endotoxin was administrated (4 mg/kg) ADMA level increased, nitric oxide level did not change but L-arginine level and L-arginine/ADMA ratio decreased. When taurine was administrated (300 mg/kg) no effect on ADMA and nitric oxide levels was observed compared to the endotoxemia group. But it was increased the L-arginine/ADMA ratio. Taurine may offer an advantage in because of it increases the reduced L-arginine/ADMA ratio.
authors.affiliation: Department of Biology, Faculty of Arts and Science, Gazi University, 06500, Teknikokullar, Ankara, Turkey. bbalabanli@gazi.edu.tr
authors.forename: Barbaros
authors.initials: B
authors.lastname: Balabanli
authors.forename: Hüsamettin
authors.initials: H
authors.lastname: Erdamar
authors.forename: Nurten
authors.initials: N
authors.lastname: Türközkan
authors.forename: Halil
authors.initials: H
authors.lastname: Yaman
authors.forename: Yasemin
authors.initials: Y
authors.lastname: Kurt
mesh_terms: D000818:Animals; D001120:Arginine / Q000031:analogs & derivatives* / Q000097:blood*; D019446:Endotoxemia / Q000188:drug therapy*; D004731:Endotoxins / Q000494:pharmacology*; D006168:Guinea Pigs; D008297:Male; D023421:Models, Animal; D009569:Nitric Oxide / Q000097:blood*; D013654:Taurine / Q000494:pharmacology*
chemical_list: D004731:Endotoxins; C487735:dimethylarginine; D013654:Taurine; D009569:Nitric Oxide; D001120:Arginine