Integrated microreaction system for optical resolution of racemic amino acids.
We developed a novel microreaction system for optical resolution of racemic amino acids. This device, which is based on a continuous microfluidic system, consists of an enzyme-immobilized microreactor and a microextractor. Use of the enzyme-microreactor, which was prepared by membrane formation on the microchannel surface, enabled a highly enantioselective reaction for a racemic amino acid derivative. The microextractor provided a laminar flow of two immiscible solutions, which enabled selective extraction of the product. Using this integrated device, we could perform efficient continuous production of optically pure unnatural amino acids.
Honda
Takeshi
T
Nanotechnology Research Institute, National Institute of Advanced Industrial Science and Technology, 807-1 Shuku, Tosu, Saga, 841-0052, Japan.
Miyazaki
Masaya
M
Yamaguchi
Yoshiko
Y
Nakamura
Hiroyuki
H
Maeda
Hideaki
H
D000596:Amino Acids / Q000737:chemistry / Q000302:isolation & purification*; D013237:Stereoisomerism; D018511:Systems Integration
D000596:Amino Acids