title: Nitrile-promoted Rh-catalyzed intermolecular hydroacylation of olefins with salicylaldehyde.
abstract: Rh-catalyzed intermolecular hydroacylation between salicylaldehyde and alkenylnitriles proceeded at room temperature to preferentially give normal-hydroacylated products. Addition of CH3CN and NaOAc accelerated the Rh-catalyzed hydroacylation of monoolefins to exclusively produce the normal-hydroacylated products under mild reaction conditions. Plausible mechanisms for the regioselections are also described.
authors.affiliation: Hokkaido College of Pharmacy, Hokkaido 047-0264, Japan.
authors.forename: Masanori
authors.initials: M
authors.lastname: Imai
authors.forename: Masakazu
authors.initials: M
authors.lastname: Tanaka
authors.forename: Shinji
authors.initials: S
authors.lastname: Nagumo
authors.forename: Norio
authors.initials: N
authors.lastname: Kawahara
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Suemune
mesh_terms: D000215:Acylation; D000447:Aldehydes / Q000737:chemistry*; D000475:Alkenes / Q000737:chemistry*; D002384:Catalysis; D006859:Hydrogen / Q000737:chemistry*; D015394:Molecular Structure; D009570:Nitriles / Q000737:chemistry*; D012238:Rhodium / Q000737:chemistry*
chemical_list: D000447:Aldehydes; D000475:Alkenes; D009570:Nitriles; C013243:salicylaldehyde; D006859:Hydrogen; D012238:Rhodium