title: Inverse correlation between tumor perfusion and glucose uptake in human head and neck tumors.
abstract: OBJECTIVE
  We sought to determine the relationship between tumor blood flow and glucose uptake in head and neck tumors using perfusion computed tomography (PCT) and fluorine-18-fluorodeoxyglucose (FDG) positron emission tomography (PET).
  
  
  METHODS
  Institutional review board approval and informed consent were obtained for this study. Sixteen patients (mean age, 67 years; age range, 36-89 years) who had known or suspected head and neck tumors (15 malignant tumors and one schwannoma) underwent PCT and FDG PET examinations. Tumor area was measured on conventional CT images. The PCT data were postprocessed using maximum slope method analysis, and standardized uptake value (SUV) was measured on FDG PET.
  
  
  RESULTS
  Mean arterial perfusion of the tumors was 61.56 mL/min/100 mL (range 22.17-102.7 mL/min/100 mL), and mean FDG SUV was 7.48 (range 2.74-17.1). A significant negative correlation between arterial perfusion and FDG SUV was found for malignant tumors (r = -0.538, P = .04, n = 15).
  
  
  CONCLUSIONS
  There was an inverse relationship between arterial perfusion and glucose uptake of head and neck malignant tumors, suggesting that the malignant tumors may depend on anaerobic glycolysis.
authors.affiliation: Department of Diagnostic and Interventional Radiology, Gunma Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma 371-8511, Japan. hrsw@aurora.dti.ne.jp
authors.forename: Satoshi
authors.initials: S
authors.lastname: Hirasawa
authors.forename: Yoshito
authors.initials: Y
authors.lastname: Tsushima
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Takei
authors.forename: Hiromi
authors.initials: H
authors.lastname: Hirasawa
authors.forename: Ayako
authors.initials: A
authors.lastname: Taketomi-Takahashi
authors.forename: Akie
authors.initials: A
authors.lastname: Takano
authors.forename: Noboru
authors.initials: N
authors.lastname: Oriuchi
authors.forename: Keigo
authors.initials: K
authors.lastname: Endo
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D019788:Fluorodeoxyglucose F18; D005947:Glucose / Q000378:metabolism*; D006258:Head and Neck Neoplasms / Q000098:blood supply* / Q000175:diagnosis / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D014057:Tomography, X-Ray Computed
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D005947:Glucose