title: Importance of intravertebral fracture clefts in vertebroplasty outcome.
abstract: OBJECTIVE
  The importance of filling intravertebral fracture clefts with polymethylmethacrylate during percutaneous vertebroplasty to maximize stabilization of fracture fragments has been emphasized in the literature. The purpose of this study was to determine whether patients with a single compression fracture with an intravertebral cleft have better outcome after percutaneous vertebroplasty than do patients with a compression fracture but no cleft.
  
  
  METHODS
  A retrospective study was conducted to review 354 consecutive percutaneous vertebroplasty procedures on 694 compression fractures. Patients were excluded from consideration if they were treated for metastatic compression fracture or if they were treated at more than a single vertebral body level. Sixty-five patients met the inclusion criteria. Preprocedure radiographs and MR images were reviewed with specific attention to the presence or absence of intravertebral gas or fluid. Images obtained at the procedure also were reviewed for the presence or absence of an intravertebral cleft. Imaging findings were correlated with subjective pain scores immediately, 2 weeks, 1 month, 3 months, 6 months, 1 year, and 2 years after the procedure.
  
  
  RESULTS
  Thirty-one (48%) of the 65 patients had evidence of a fracture cleft. Twenty-seven patients had opacification of an intravertebral fracture cleft at percutaneous vertebroplasty, and four patients had an intravertebral cleft on preprocedure imaging but did not have cleft opacification. Thirty-four (52%) of the patients had no evidence of a fracture cleft and had only a trabecular pattern of opacification. Although there was a trend toward a greater failure rate in patients with a filled cleft, there was no statistically significant difference in subjective pain scores between the groups.
  
  
  CONCLUSIONS
  Pain relief with vertebroplasty is similar in patients with and those without intravertebral fracture clefts. Because of the small number of unfilled fracture clefts in our population, the true incidence of post-percutaneous vertebroplasty pain in patients with an un-filled cleft remains uncertain.
authors.affiliation: Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 S Kingshighway Blvd., Campus Box 8131, St. Louis, MO 63110, USA.
authors.forename: Matthew C
authors.initials: MC
authors.lastname: Wiggins
authors.forename: Mehrdad
authors.initials: M
authors.lastname: Sehizadeh
authors.forename: Thomas K
authors.initials: TK
authors.lastname: Pilgram
authors.forename: Louis A
authors.initials: LA
authors.lastname: Gilula
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001843:Bone Cements / Q000627:therapeutic use; D003131:Combined Modality Therapy / Q000379:methods; D005260:Female; D050815:Fractures, Compression / Q000000981:diagnostic imaging / Q000453:epidemiology* / Q000628:therapy*; D006801:Humans; D007796:Laminectomy / Q000379:methods / Q000706:statistics & numerical data*; D008297:Male; D008875:Middle Aged; D008923:Missouri / Q000453:epidemiology; D017063:Outcome Assessment, Health Care / Q000379:methods / Q000706:statistics & numerical data; D019904:Polymethyl Methacrylate / Q000627:therapeutic use*; D011379:Prognosis; D011859:Radiography; D012189:Retrospective Studies; D018570:Risk Assessment / Q000379:methods; D012307:Risk Factors; D016103:Spinal Fractures / Q000000981:diagnostic imaging / Q000453:epidemiology* / Q000628:therapy*; D016896:Treatment Outcome
chemical_list: D001843:Bone Cements; D019904:Polymethyl Methacrylate