Functional derangement and cardiac innervation in the apical ballooning syndrome: a 123I-meta-iodobenzylguanidine scintigraphic and dobutamine stress echocardiographic study.
Several cases of transient left ventricular apical ballooning syndrome have already been described, but the pathophysiological mechanisms of this syndrome still remain unclear. We report the case of a patient evaluated in the acute phase of apical ballooning by coronary angiography and echocardiography who was submitted to I-meta-iodobenzylguanidine (MIBG) myocardial scintigraphy and dobutamine stress echocardiography one month after the discharge. MIBG scintigraphy demonstrated a decreased tracer uptake in the apical and periapical anterior regions, whilst myocardial perfusion at rest was normal. Dobutamine induced an increased left ventricular outflow tract gradient and hypokinesis in the apical and periapical segments, mimicking the findings that occurred in the acute phase, and in agreement with the location of MIBG abnormalities. After a two-month treatment with carvedilol, MIBG uptake increased in the apical and periapical anterior regions.
Moreo
Antonella
A
Cardiology Department, Niguarda Ca' Granda Hospital, Milan, Italy.
De Chiara
Benedetta
B
Possa
Mario
M
Sara
Roberto
R
Bossi
Irene
I
Orrego
Pedro Silva
PS
Nicolosi
Elisa
E
Mauri
Francesco
F
Parodi
Oberdan
O
D019797:3-Iodobenzylguanidine; D000368:Aged; D017023:Coronary Angiography; D025401:Echocardiography, Stress; D004562:Electrocardiography; D005260:Female; D006801:Humans; D015425:Myocardial Reperfusion; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D013577:Syndrome; D018487:Ventricular Dysfunction, Left / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000503:physiopathology*
D019275:Radiopharmaceuticals; D019797:3-Iodobenzylguanidine