[Serotonin transporter gene polymorphism modulates psychic maladaptation in relatives of patients with endogenic psychoses].
An association between serotonin transporter gene 5-HTTLPR polymorphism and development of depressive states in response to different distant and proximal stressors has been reported previously. We studied 5-HTTLPR polymorphism effect on probability of development of mental maladaptation and its peculiarities in 224 relatives of patients with severe chronic mental disorders: schizophrenia, schizoaffective and affective disorders. The SS genotype was associated with elevation on the scale Hypochondriasis of the MMPI that indicated intensity of the autonomic component of anxiety and more concern about health as well as increased sensitivity. At the same time, its relation to depression and anxiety measured by the scale Depression was tentative. The association was stronger in men than in women. Moreover, men with the SS genotype were more tense, suspicious, detached and experienced difficulties in concentration (scales Paranoia and Schizophrenia) as compared to those with other genotypes. The results imply a role of the short allele in augmenting and modulation of psychopathological reaction in response to chronic stressful situation in relatives of psychotic patients.
Alfimova
M V
MV
Golimbet
V E
VE
Korovaĭtseva
G I
GI
Lezheĭko
T V
TV
Abramova
L I
LI
Kaleda
V G
VG
Barkhatova
A N
AN
D000223:Adaptation, Psychological / Q000502:physiology*; D000328:Adult; D004247:DNA / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D011379:Prognosis; D011618:Psychotic Disorders / Q000235:genetics* / Q000378:metabolism; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*
D050486:Serotonin Plasma Membrane Transport Proteins; D004247:DNA