title: Baseline level of platelet-leukocyte aggregates, platelet CD63 expression, and soluble P-selectin concentration in patients with posttraumatic stress disorder: a pilot study.
abstract: Platelets may have an important role in the development of cardiovascular disease (CVD) as a result of chronic stress. We conducted a pilot study to evaluate the effect of posttraumatic stress disorder (PTSD) on baseline platelet activation. Platelet-leukocyte aggregates (PLA) and CD63 expression were measured by flow cytometry, and soluble (s)P-selectin concentration was determined in sera of 20 Croatian male combat veterans with PTSD and 20 healthy civilians. Groups were matched in sex, age, body mass index (BMI) and traditional CVD risk factors. Our data showed no differences in measured parameters. Other platelet activation markers should be determined and a larger sample size used in future studies.
authors.affiliation: Department for Cellular Immunology, Institute of Immunology, Rockefellerova 10, HR-10 000 Zagreb, Croatia. avidovic@imz.hr
authors.forename: Andelko
authors.initials: A
authors.lastname: Vidović
authors.forename: Maja
authors.initials: M
authors.lastname: Vilibić
authors.forename: Alemka
authors.initials: A
authors.lastname: Markotić
authors.forename: Ante
authors.initials: A
authors.lastname: Sabioncello
authors.forename: Katja
authors.initials: K
authors.lastname: Gotovac
authors.forename: Vera
authors.initials: V
authors.lastname: Folnegović-Smalc
authors.forename: Dragan
authors.initials: D
authors.lastname: Dekaris
mesh_terms: D000328:Adult; D015703:Antigens, CD / Q000097:blood*; D001792:Blood Platelets / Q000378:metabolism*; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000097:blood; D003130:Combat Disorders / Q000097:blood* / Q000175:diagnosis / Q000523:psychology; D017523:Croatia; D005434:Flow Cytometry; D006801:Humans; D007962:Leukocytes / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D019007:P-Selectin / Q000097:blood*; D010865:Pilot Projects; D010974:Platelet Aggregation / Q000502:physiology*; D010980:Platelet Membrane Glycoproteins; D012307:Risk Factors; D060149:Tetraspanin 30; D014728:Veterans / Q000523:psychology*
chemical_list: D015703:Antigens, CD; C554586:CD63 protein, human; D019007:P-Selectin; D010980:Platelet Membrane Glycoproteins; D060149:Tetraspanin 30