title: [Expression of HOXC13 in ameloblastoma].
abstract: OBJECTIVE
  To study the expression of HOXC13 mRNA in ameloblastoma (AB), and to investigate its biological significance.
  
  
  METHODS
  HOXC13 mRNA was examined in 47 cases of AB (primary AB 29 cases, recurrent AB 14 cases, malignant AB 4 cases). 2 cases of fibrous dysplasia of bone, 10 cases of keratocystic odontogenic tumor (KCOT) and 7 cases of normal oral mucosa were selected as control.
  
  
  RESULTS
  The positive rates of HOXC13 mRNA in AB, KCOT, and normal oral mucosa were 97.9% (46/47), 7/10 and 3/7, respectively. There was a significant difference among AB, OKC and normal mucosa (chi(2) = 21.665, P = 0.001). For HOXC13, the keratinizing cells and granulizing cells in AB were negative, some fibroblasts were positive, 2 cases of fibrous dysplasia of bone were positive.
  
  
  CONCLUSIONS
  HOXC13 was highly expressed in AB. The expression of HOXC13 mRNA in AB had heterogeneity, which could improve the epithelial proliferation, and its loss may lead to the cornification and degeneration of epithelial cells.
authors.affiliation: Department of Pathology, School of Stomatology, China Medical University, Shenyang 110002, China. zhongming_oral@yahoo.com.cn
authors.forename: Ming
authors.initials: M
authors.lastname: Zhong
authors.forename: Jie
authors.initials: J
authors.lastname: Wang
authors.forename: Yan-bing
authors.initials: YB
authors.lastname: Gong
authors.forename: Jin-cheng
authors.initials: JC
authors.lastname: Li
authors.forename: Bo
authors.initials: B
authors.lastname: Zhang
authors.forename: Lin
authors.initials: L
authors.lastname: Hou
mesh_terms: D000293:Adolescent; D000328:Adult; D000564:Ameloblastoma / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D005260:Female; D015870:Gene Expression; D005801:Genes, Homeobox; D018398:Homeodomain Proteins / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa / Q000378:metabolism; D009808:Odontogenic Tumors / Q000235:genetics / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism; D055815:Young Adult
chemical_list: C410305:HOXC13 protein, human; D018398:Homeodomain Proteins; D012333:RNA, Messenger