Patch test results with patients' own perfumes, deodorants and shaving lotions: results of the IVDK 1998-2002.
OBJECTIVE
Assessment of the value of patch testing patients' own perfumes, eau de toilette, deodorants and shaving lotions with regard to diagnosing contact allergy to fragrances, and an analysis of the spectrum of concurrent patch test reactions to single fragrance allergens.


METHODS
Data of the Information Network of Departments of Dermatology (IVDK; http://www.ivdk.org) regarding patch test results with above products brought in by the patient, considered as possible cause of contact dermatitis, were retrospectively analysed. Between 1998 and 2002, 1468 patients were patch tested with 2557 single products (deodorants, n = 1094; eau de toilette, n = 598; perfume, n = 530; and pre- or after-shave, n = 325; remainder not classifiable), mostly 'as is'.


RESULTS
Positive reactions were observed in 129 patients (to 191 products). In 58 of these patients, no further patch test reactions to the fragrance mix (FM-I), Myroxylon pereirae resin (balsam of Peru) or 4-(4-hydroxy-4-methyl-pentyl)-3-cyclohexencarboxaldehyde (e.g. Lyral(R)) were found. A strong association between contact sensitivity to the above commercial allergens and positive reactions to products was observed. Some single compounds such as ylang-ylang oil, propolis and especially oak moss absolute are important allergens in the 'perfume-positive' subgroup, but less in a subgroup positive to own deodorants.


CONCLUSIONS
Patch testing this scope of products, brought in by the patient, can be regarded as a simple, safe and effective method to diagnose clinically relevant contact sensitization - the more so, as the composition of such products is ever-changing, and the sensitivity of established 'screening allergens' is thus insufficient.
Uter
W
W
Department of Medical Informatics, Biometry and Epidemiology, University of Erlangen-Nürnberg, Waldstrasse 6, D-91054 Erlangen, Germany.
Geier
J
J
Schnuch
A
A
Frosch
P J
PJ
D000447:Aldehydes / Q000009:adverse effects; D001453:Balsams / Q000009:adverse effects; D053138:Cyclohexenes / Q000009:adverse effects; D003836:Deodorants / Q000009:adverse effects*; D017449:Dermatitis, Allergic Contact / Q000175:diagnosis* / Q000453:epidemiology; D005054:Eugenol / Q000009:adverse effects / Q000031:analogs & derivatives; D005260:Female; D005858:Germany / Q000453:epidemiology; D006801:Humans; D008297:Male; D010328:Patch Tests; D010476:Perfume / Q000009:adverse effects*; D011429:Propolis / Q000009:adverse effects; D012116:Resins, Plant / Q000009:adverse effects; D012915:Soaps / Q000009:adverse effects*; D014425:Turpentine / Q000009:adverse effects
D000447:Aldehydes; D001453:Balsams; D053138:Cyclohexenes; D003836:Deodorants; D010476:Perfume; D012116:Resins, Plant; D012915:Soaps; D005054:Eugenol; C036643:isoeugenol; C025080:Peruvian balsam; D011429:Propolis; C092244:hydroxyisohexyl 3-cyclohexene carboxaldehyde; D014425:Turpentine