Acquired angioedema in non-Hodgkin's lymphoma.
This paper describes a middle-aged patient who developed repeated episodes of swelling of the orofacial tissues after dental treatment. On investigation, C1 inhibitor, C1q, C2, and C4 levels were all markedly reduced, and a diagnosis of acquired C1 inhibitor deficiency was made. The patient had been diagnosed with non-Hodgkin's lymphoma (NHL) 2 years previously and had undergone a successful course of chemotherapy. The development of her episodes of angioedema prompted thorough reinvestigation and a recurrence of NHL was identified. Therefore, acquired C1 inhibitor deficiency heralded a recurrence, although this had not been a manifestation when NHL was first diagnosed. The patient underwent a further course of chemotherapy and remains well, although C1 inhibitor, C1q, C2, and C4 levels remain reduced.
Healy
Claire
C
Department of Oral and Maxillofacial Surgery, Oral Medicine and Oral Pathology, Dublin Dental School and Hospital, Trinity College Dublin, Dublin, Ireland. claire.healy@dental.tcd.ie
Abuzakouk
Mohamed
M
Feighery
Conleth
C
Flint
Stephen
S
D000799:Angioedema / Q000097:blood / Q000209:etiology* / Q000276:immunology; D001365:Axilla; D050718:Complement C1 Inhibitor Protein / Q000032:analysis; D015922:Complement C1q / Q000032:analysis; D003175:Complement C2 / Q000032:analysis; D003181:Complement C4 / Q000032:analysis; D003171:Complement Pathway, Classical; D005145:Face; D005260:Female; D006801:Humans; D007147:Immunoglobulin Light Chains / Q000737:chemistry; D008198:Lymph Nodes; D008228:Lymphoma, Non-Hodgkin / Q000150:complications*; D008875:Middle Aged; D009333:Neck; D009364:Neoplasm Recurrence, Local; D010265:Paraproteinemias / Q000097:blood
D050718:Complement C1 Inhibitor Protein; D003175:Complement C2; D003181:Complement C4; D007147:Immunoglobulin Light Chains; D015922:Complement C1q