title: HPLC-ICP-MS and HPLC-ES-MS/MS characterization of synthetic seleno-arsenic compounds.
abstract: Various toxicological and metabolic interactions have been reported to exist between arsenic and selenium. In the present study, synthetic seleno-arsenic compounds, potentially suitable for probing metabolic interactions between these two elements, were prepared and tentatively characterized by using high-performance liquid chromatography (HPLC)-electrospray tandem mass spectrometry and HPLC-inductively coupled plasma mass spectrometry. In analogy to the recently identified thio-arsenic species, which can be prepared from their corresponding oxo-arsenic species via reaction with H(2)S, the seleno-arsenic compounds were also derived from oxo-arsenic compounds via reaction with H(2)Se. Figure H(2)Se bubbled into solutions containing oxo-arseno-sugars converts them into their seleno-arseno-sugar analogues.
authors.affiliation: Environmental Chemical Processes Laboratory, Department of Chemistry, University of Crete, Voutes, 71003 Heraklion, Crete, Greece.
authors.forename: Katerina
authors.initials: K
authors.lastname: Kanaki
authors.forename: Spiros A
authors.initials: SA
authors.lastname: Pergantis
mesh_terms: D001152:Arsenicals / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D018036:Selenium Compounds / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods*; D053719:Tandem Mass Spectrometry / Q000379:methods*
chemical_list: D001152:Arsenicals; D018036:Selenium Compounds