[Injury and epithelial wound healing: a pathophysiologic hypothesis for nasal and sinus polyposis].
Nasal polyposis (NP), asthma, and chronic bronchitis are chronic inflammatory diseases of the upper airways. They may be caused by injury to the respiratory epithelium in a chronic inflammatory environment. Several studies show that during NP nasal epithelial cells are involved in the overexpression of cytokines and growth factors. Among these, transforming growth factor beta1 (TGF-beta1) appears to play a major role in the genesis of NP. Differentiated respiratory epithelium, obtained from in vivo or in vitro models, is used to study wound healing in inflammatory environments, to elucidate the pathophysiology of NP, and to improve understanding and management of upper airway inflammatory diseases.
Lazard
Diane S
DS
Unité Inserm U651, Créteil, Service ORL et chirurgie cervicofaciale, Hôpital Foch, Suresnes. dianelazard@yahoo.fr
Prulière-Escabasse
Virginie
V
Papon
Jean-François
JF
Escudier
Estelle
E
Coste
André
A
D000208:Acute Disease; D000465:Algorithms; D000818:Animals; D001249:Asthma / Q000150:complications; D001991:Bronchitis / Q000150:complications; D018929:Cell Culture Techniques; D016207:Cytokines / Q000502:physiology; D003663:Decision Trees; D004195:Disease Models, Animal; D006801:Humans; D007249:Inflammation; D036341:Intercellular Signaling Peptides and Proteins / Q000502:physiology; D009297:Nasal Mucosa / Q000293:injuries; D009298:Nasal Polyps / Q000209:etiology* / Q000628:therapy; D010254:Paranasal Sinus Diseases / Q000209:etiology* / Q000628:therapy; D010256:Paranasal Sinuses / Q000293:injuries*; D011127:Polyps / Q000209:etiology* / Q000628:therapy; D020545:Respiratory Mucosa / Q000276:immunology / Q000293:injuries* / Q000503:physiopathology; D053773:Transforming Growth Factor beta1 / Q000502:physiology; D014945:Wound Healing / Q000502:physiology*
D016207:Cytokines; D036341:Intercellular Signaling Peptides and Proteins; D053773:Transforming Growth Factor beta1