title: Rotavirus vaccines--an update.
abstract: Rotavirus infection is the most common cause of severe diarrhea disease in infants and young children worldwide and continues to have a major global impact on childhood morbidity and mortality. Vaccination is the only control measure likely to have a significant impact on the incidence of severe dehydrating rotavirus disease. Rotavirus disease prevention efforts suffered a severe setback in 1999 with the withdrawal of the RRV-TV vaccine less than a year after its introduction. Several new rotavirus vaccines have been developed and have proven to be safe and efficacious. These new safe and effective rotavirus vaccines offer the best hope of reducing the toll of acute rotavirus gastroenteritis in both developed and developing countries.
authors.affiliation: Division of Pediatric Infectious Diseases, Rhode Island Hospital and the Department of Pediatrics, Brown Medical School, 593 Eddy Street, Providence, RI 02903, United States. pdennehy@lifespan.org
authors.forename: Penelope H
authors.initials: PH
authors.lastname: Dennehy
mesh_terms: D002675:Child, Preschool; D003967:Diarrhea / Q000517:prevention & control*; D006801:Humans; D007223:Infant; D007443:Intussusception / Q000139:chemically induced; D012400:Rotavirus Infections / Q000453:epidemiology / Q000517:prevention & control*; D022243:Rotavirus Vaccines / Q000009:adverse effects / Q000235:genetics / Q000627:therapeutic use*; D014613:Vaccines, Attenuated / Q000009:adverse effects / Q000627:therapeutic use
chemical_list: D022243:Rotavirus Vaccines; D014613:Vaccines, Attenuated; C052014:rhesus rotavirus vaccine