Cutaneous Langerhans cell sarcoma: a case report and review of the literature.
Langerhans cell sarcoma (LCS) is a neoplastic proliferation of Langerhans cells that occurs in lymph nodes, liver, skin, spleen, lung, and bone. We report a case of LCS in a 47-year-old man with a 6-month history of scalp mass and cervical lymphadenopathy. Clinical and pathologic data were available. A histologic examination demonstrated a proliferation of cells with malignant cytologic features. Because of its poorly differentiated morphologic features, hematologic and nonhematologic entities were ruled out by immunohistochemical screening with a broad panel of antibodies. Ultrastructural studies demonstrating Birbeck granules and consistent expression of CD1a, S-100 protein, and langerin by immunohistochemistry were helpful in identifying the Langerhans cell origin.
Bohn
Olga L
OL
Department of Pathology, University Hospital UPAEP, Puebla, Mexico.
Ruiz-Argüelles
Guillermo
G
Navarro
Leticia
L
Saldivar
Jesus
J
Sanchez-Sosa
Sergio
S
D003594:Cytoplasmic Granules / Q000378:metabolism / Q000648:ultrastructure; D015972:Gene Expression Regulation, Neoplastic; D006258:Head and Neck Neoplasms / Q000378:metabolism / Q000648:ultrastructure*; D006801:Humans; D007801:Langerhans Cells / Q000378:metabolism / Q000648:ultrastructure*; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000096:biosynthesis; D012878:Skin Neoplasms / Q000378:metabolism / Q000648:ultrastructure*
D009363:Neoplasm Proteins