Emergency use of sugammadex after failure of standard reversal drugs.
Administration of sugammadex, 350 mg IV (4 mg/kg), in the postanesthesia care unit immediately (<60 s) relieved acute respiratory distress due to residual neuromuscular blockade in a 42-yr-old patient with chronic renal failure who had received vecuronium, 10 mg IV, for tracheal intubation, after inadequate reversal of neuromuscular blockade in the operating room with neostigmine, 5 mg IV, and glycopyrrolate, 1 mg IV.
Lenz
Adam
A
Department of Anesthesiology and Pain Management; University of Texas Southwestern Medical Center, Dallas, Texas 75390-9068, USA.
Hill
Gary
G
White
Paul F
PF
D000328:Adult; D000762:Anesthesia Recovery Period; D006024:Glycopyrrolate / Q000037:antagonists & inhibitors; D006801:Humans; D008297:Male; D019148:Neuromuscular Blockade; D003473:Neuromuscular Nondepolarizing Agents / Q000037:antagonists & inhibitors; D000077122:Sugammadex; D013997:Time Factors; D016896:Treatment Outcome; D014673:Vecuronium Bromide / Q000037:antagonists & inhibitors; D047408:gamma-Cyclodextrins / Q000494:pharmacology*
D003473:Neuromuscular Nondepolarizing Agents; D047408:gamma-Cyclodextrins; D000077122:Sugammadex; D014673:Vecuronium Bromide; D006024:Glycopyrrolate