title: Acute ST-segment elevation myocardial infarction complicating amoxycillin-induced anaphylaxis: a case report.
abstract: A 70-year-old man experienced an amoxycillin-induced anaphylactic reaction complicated by acute inferior myocardial infarction with transient ST-segment elevation. There was a spontaneous resolution of ST-segment elevation and the patient was treated for anaphylaxis. Coronary angiography showed severe obstructive coronary atherosclerosis, but not involving the infarct-related artery. Percutaneous coronary intervention of the affected artery was then performed and the patient was discharged three days later. Acute ST-elevation myocardial infarction has been described as one of the severe, still rare cardiovascular complications of anaphylaxis. In the present case, according to the previous reports, the main pathogenetic mechanism involved appears to have been coronary vasospasm probably caused by the release of potent vasoactive mast cell derived mediators in the setting of anaphylaxis.
authors.forename: Francesca
authors.initials: F
authors.lastname: Del Furia
authors.forename: Loreno
authors.initials: L
authors.lastname: Querceto
authors.forename: Sergio
authors.initials: S
authors.lastname: Testi
authors.forename: Giovanni Maria
authors.initials: GM
authors.lastname: Santoro
mesh_terms: D000368:Aged; D000658:Amoxicillin / Q000009:adverse effects*; D000707:Anaphylaxis / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy; D023921:Coronary Stenosis / Q000150:complications / Q000175:diagnosis / Q000628:therapy; D004342:Drug Hypersensitivity / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D004562:Electrocardiography; D006801:Humans; D008297:Male; D009203:Myocardial Infarction / Q000150:complications* / Q000175:diagnosis; D016896:Treatment Outcome
chemical_list: D000658:Amoxicillin