title: Enterococcus faecalis mutations affecting virulence in the Caenorhabditis elegans model host.
abstract: Enterococcus faecalis transposon insertion mutants were screened for attenuated killing of the nematode model host Caenorhabditis elegans. The genes disrupted in the attenuated mutants encode a variety of factors including transcriptional regulators, transporters, and damage control and repair systems. Five of nine mutants tested were attenuated in a mouse peritonitis model.
authors.affiliation: Department of Microbiology and Molecular Genetics, The University of Texas Health Science Center at Houston, 6431 Fannin St./MSB 1.174, Houston, TX 77030, USA.
authors.forename: Arash
authors.initials: A
authors.lastname: Maadani
authors.forename: Kristina A
authors.initials: KA
authors.lastname: Fox
authors.forename: Elftherios
authors.initials: E
authors.lastname: Mylonakis
authors.forename: Danielle A
authors.initials: DA
authors.lastname: Garsin
mesh_terms: D000818:Animals; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D017173:Caenorhabditis elegans / Q000382:microbiology*; D013293:Enterococcus faecalis / Q000235:genetics / Q000472:pathogenicity*; D016908:Gram-Positive Bacterial Infections / Q000382:microbiology / Q000401:mortality; D051379:Mice; D009154:Mutation; D010538:Peritonitis / Q000382:microbiology* / Q000401:mortality; D014774:Virulence / Q000235:genetics
chemical_list: D001426:Bacterial Proteins