A new anticoagulant-antidote pair: control of thrombin activity by aptamers and porphyrins.
Joachimi
Astrid
A
Department of Chemistry, University of Konstanz, Universitätsstr. 10, 78457 Konstanz, Germany.
Mayer
Günter
G
Hartig
Jörg S
JS
D000925:Anticoagulants / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D052157:Aptamers, Nucleotide / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000378:metabolism; D001777:Blood Coagulation / Q000187:drug effects; D004247:DNA / Q000737:chemistry / Q000378:metabolism; D004347:Drug Interactions; D054856:G-Quadruplexes; D006801:Humans; D008958:Models, Molecular; D011166:Porphyrins / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D013917:Thrombin / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000378:metabolism
D000925:Anticoagulants; D052157:Aptamers, Nucleotide; D011166:Porphyrins; C021096:tetra(4-N-methylpyridyl)porphine; D004247:DNA; D013917:Thrombin