The X-linked adrenoleukodystrophy (X-ALD) and oxidative stress.
Most of the studies indicate that there is as yet no complete cure for X-ALD. However, methods of the treatment seem to slow rather than treat the disease. One method is the use of Lorenzo's oil in conjunction with a low fat diet, which may help in cerebral X-ALD. X-ALD is in very close resemblance to another neurodegenerative disease, amyotrophic lateral sclerosis (ALS). One of the believed pathomechanisms of ALS is oxidative stress; therefore, this article's emphasis on the role of reactive oxygen species in X-ALD. The aim of the present study was to review the literature concerning the advances in the treatment of X-adrenoleukodystrophy (X-ALD, OMIM # 300100) in the last two decades and to shed more light on the link between oxidative stress and X-ALD. This review article may point to a deficit in reactive oxygen species (ROS) scavenging and/or ROS overproduction being involved in the aetiopathology of these neurodegenerative diseases. Consequently, one of the useful neuronal rescue strategies could be the treatment with antioxidant agents.
Al-Omar
Mohamed A
MA
Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia. drmohammed1423@yahoo.co.uk
D000326:Adrenoleukodystrophy / Q000378:metabolism / Q000628:therapy*; D000690:Amyotrophic Lateral Sclerosis / Q000628:therapy; D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D004338:Drug Combinations; D004883:Erucic Acids / Q000627:therapeutic use*; D016166:Free Radical Scavengers / Q000627:therapeutic use; D006801:Humans; D018384:Oxidative Stress; D017382:Reactive Oxygen Species; D014304:Triolein / Q000627:therapeutic use*
D000975:Antioxidants; D004338:Drug Combinations; D004883:Erucic Acids; D016166:Free Radical Scavengers; C079420:Lorenzo's oil; D017382:Reactive Oxygen Species; D014304:Triolein