title: Synthetic cinnamylphenol derivatives as cancer chemopreventive agents.
abstract: Several substituted cinnamylphenol (1,3-diphenylpropene) derivatives were synthesized and tested for their inhibitory activities against in vitro Epstein-Barr virus early antigen activation induced by 12-O-tetradecanoylphorbol-13-acetate in Raji cells. The prenylated cinnamylphenols were found to show remarkably potent activity. Furthermore, prenylated cinnamylphenols (19 and 25) exhibited a marked inhibitory effect on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test. These results indicate that some prenylated cinnamylphenols might be valuable as potential cancer chemopreventive agents (anti-tumor promoters).
authors.affiliation: Faculty of Pharmacy, Meijo University, Tempaku-ku, Nagoya 468-8503, Japan.
authors.forename: Chihiro
authors.initials: C
authors.lastname: Ito
authors.forename: Masataka
authors.initials: M
authors.lastname: Itoigawa
authors.forename: Tetsufumi
authors.initials: T
authors.lastname: Kanematsu
authors.forename: Yuuki
authors.initials: Y
authors.lastname: Imamura
authors.forename: Harukuni
authors.initials: H
authors.lastname: Tokuda
authors.forename: Hoyoku
authors.initials: H
authors.lastname: Nishino
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Furukawa
mesh_terms: D000475:Alkenes / Q000138:chemical synthesis* / Q000494:pharmacology*; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004854:Herpesvirus 4, Human; D006801:Humans; D051379:Mice; D015394:Molecular Structure; D009369:Neoplasms / Q000473:pathology / Q000517:prevention & control*; D009374:Neoplasms, Experimental / Q000473:pathology / Q000517:prevention & control; D010636:Phenols / Q000138:chemical synthesis* / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D000475:Alkenes; D000970:Antineoplastic Agents; D010636:Phenols