Electrochemical monitoring of piroxicam in different pharmaceutical forms with multi-walled carbon nanotubes paste electrode.
The electrochemical behavior of piroxicam on a multi-walled carbon nanotubes electrode for the first time was investigated. A highly sensitive and fast responding sensor for determination of piroxicam was simply and conveniently fabricated. The constructed electrode exhibits efficiently catalytic activity for the electrooxidation of piroxicam at a reduced over potential with high sensitivity, stability, and long lifetime in the wide concentration rang of piroxicam. The oxidation process was found to be dependent on the pH of the supporting electrolyte. The behavior is further exploited as a sensitive detection method for piroxicam determination by differential pulse voltammetry. Under the optimized conditions the calibration plots are linear in the concentration range of 0.15-5 microg ml(-1). Application of the method for the determination of the drug in the dosage form (Feledene capsules and tablets and also piroxicam gel), without any interference, from the excipients, resulted in acceptable deviation from the stated concentrations. Recoveries were obtained in the range 96.35-104.16%. The detection limit of 0.1 microg ml(-1) was obtained for piroxicam determination.
Abbaspour
Abdolkarim
A
Department of Chemistry, Shiraz University, Shiraz 71454, Iran. abbaspour@susc.ac.ir
Mirzajani
Roya
R
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000032:analysis / Q000737:chemistry*; D002138:Calibration; D002214:Capsules / Q000032:analysis; D002384:Catalysis; D004304:Dosage Forms; D004355:Drug Stability; D004563:Electrochemistry / Q000295:instrumentation / Q000379:methods*; D004566:Electrodes; D005079:Excipients / Q000032:analysis; D005782:Gels / Q000032:analysis; D006863:Hydrogen-Ion Concentration; D015394:Molecular Structure; D037742:Nanotubes, Carbon / Q000737:chemistry*; D010084:Oxidation-Reduction; D004364:Pharmaceutical Preparations / Q000008:administration & dosage / Q000032:analysis / Q000737:chemistry*; D010894:Piroxicam / Q000008:administration & dosage / Q000032:analysis / Q000737:chemistry*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013607:Tablets / Q000032:analysis
D000894:Anti-Inflammatory Agents, Non-Steroidal; D002214:Capsules; D004304:Dosage Forms; D005079:Excipients; D005782:Gels; D037742:Nanotubes, Carbon; D004364:Pharmaceutical Preparations; D013607:Tablets; D010894:Piroxicam