title: Intracerebral regional distribution of blood flow in response to uterine contractions in growth-restricted human fetuses.
abstract: OBJECTIVE
  To explore middle cerebral artery (MCA) and anterior cerebral artery (ACA) blood flow responses to superimposed acute hypoxemia in growth-restricted fetuses with and without established brain-sparing flow during basal conditions.
  
  
  METHODS
  47 term fetuses suspected of growth restriction were exposed to an oxytocin challenge test with simultaneous cardiotocography and Doppler velocimetry in the umbilical artery, MCA and ACA. The MCA-to-ACA pulsatility index (PI) ratio was calculated during basal conditions, contractions and relaxations. Basal brain-sparing flow was defined as an MCA-to-umbilical artery PI ratio of<1.08, de novo brain-sparing flow in the MCA as an MCA PI decrease with> or =1 standard deviation during uterine contractions or relaxations compared with basal measurements, and de novo brain-sparing flow in the ACA as an ACA PI decrease with > or =1 standard deviation. Non-parametric statistical tests were used with P<0.05 considered significant.
  
  
  RESULTS
  MCA and ACA PI were both significantly lower in the brain-sparing flow group (N=8) during basal conditions (P< or =0.01). During the oxytocin challenge test, MCA and ACA PI both decreased in the non-brain-sparing flow group (N=39) (P< or =0.02) but not in the brain-sparing flow group (P> or =0.4). The MCA-to-ACA PI ratio remained unchanged in both groups. de novo brain-sparing flow calculations revealed no preferential flow to any cerebral artery.
  
  
  CONCLUSIONS
  Cerebral circulatory responses to acute hypoxemia are synchronized in the middle and anterior cerebral arteries without any preferential regional flow distribution.
authors.affiliation: Department of Obstetrics and Gynecology, Malmö University Hospital, Lund University, S-205 02 Malmö, Sweden.
authors.forename: Jing
authors.initials: J
authors.lastname: Fu
authors.forename: Per
authors.initials: P
authors.lastname: Olofsson
mesh_terms: D000328:Adult; D020771:Anterior Cerebral Artery / Q000000981:diagnostic imaging / Q000187:drug effects / Q000503:physiopathology; D002560:Cerebrovascular Circulation / Q000187:drug effects / Q000502:physiology*; D005260:Female; D005317:Fetal Growth Retardation / Q000503:physiopathology*; D006801:Humans; D000860:Hypoxia / Q000503:physiopathology*; D020768:Middle Cerebral Artery / Q000000981:diagnostic imaging / Q000187:drug effects / Q000503:physiopathology; D010121:Oxytocin; D011247:Pregnancy; D012039:Regional Blood Flow / Q000187:drug effects / Q000502:physiology*; D013687:Telencephalon / Q000098:blood supply; D018608:Ultrasonography, Doppler; D016216:Ultrasonography, Prenatal; D014590:Uterine Contraction / Q000187:drug effects / Q000502:physiology*
chemical_list: D010121:Oxytocin