Up-regulation of vascular cyclooxygenase-2 in diabetes mellitus.
Diabetes mellitus is associated with disturbed regulation in the microcirculation. A low-grade vascular inflammation has been implicated in the development of diabetes-related vascular complications, but the underlying molecular mechanisms has not yet been fully elucidated. It is known that cyclooxygenase-2 (COX-2) plays a key role in prostaglandin biosynthesis during the development of inflammation. Recent studies revealed that in diabetes increased synthesis of various prostanoids, via up-regulation of COX-2, interferes with the regulation of vasomotor function. In this review, we will summarize the current findings regarding the role of COX-2, and COX-2-derived prostanoids in the regulation of vascular tone, as well as the possible underlying mechanisms leading to COX-2 activation in diabetes mellitus.
Bagi
Zsolt
Z
Division of Clinical Physiology, Institute of Cardiology, University of Debreden, Moricz Zs 22, H-4032 Debrecen, Hungary. bagizs@dote.hu
Erdei
Nóra
N
Papp
Zoltán
Z
Edes
István
I
Koller
Akos
A
D001808:Blood Vessels / Q000201:enzymology / Q000503:physiopathology; D051546:Cyclooxygenase 2 / Q000096:biosynthesis*; D003920:Diabetes Mellitus / Q000201:enzymology* / Q000503:physiopathology; D004730:Endothelium, Vascular / Q000201:enzymology* / Q000503:physiopathology; D004789:Enzyme Activation; D006801:Humans; D008833:Microcirculation / Q000201:enzymology / Q000503:physiopathology; D011453:Prostaglandins / Q000096:biosynthesis; D013928:Thromboxane A2 / Q000502:physiology; D015854:Up-Regulation
D011453:Prostaglandins; D013928:Thromboxane A2; D051546:Cyclooxygenase 2