title: Composition of EEG oscillations and their temporal characteristics: methadone treatment.
abstract: In this study, we examine the composition of electroencephalographic (EEG) oscillations within a broad frequency band (0.5-30 Hz) for opioid abuse (22 patients), during withdrawal (13 patients), and after 6 months of methadone treatment (6 patients) and in 14 healthy subjects during a resting condition (closed eyes). The exact compositions of EEG oscillations and their temporal behaviour were assessed using the probability-classification analysis of short-term EEG spectral patterns. The study reveals the dynamics of particular EEG oscillations throughout the conditions of opioid dependency, withdrawal and methadone-based treatment. It was shown that methadone maintenance treatment normalized considerably the composition of EEG oscillations and their percentage ratio and restored the temporal structure of patients' EEG comparable with healthy subjects. The importance of the methadone's ability to restore a normal temporal structure of the brain's activity is discussed.
authors.affiliation: BM-SCIENCE - Brain and Mind Technologies Research Centre, Espoo, Finland. alexander.fingelkurts@bm-science.com
authors.forename: Alexander A
authors.initials: AA
authors.lastname: Fingelkurts
authors.forename: Seppo
authors.initials: S
authors.lastname: Kähkönen
authors.forename: Andrew A
authors.initials: AA
authors.lastname: Fingelkurts
authors.forename: Reetta
authors.initials: R
authors.lastname: Kivisaari
authors.forename: Sergei
authors.initials: S
authors.lastname: Borisov
authors.forename: Varpu
authors.initials: V
authors.lastname: Puuskari
authors.forename: Olga
authors.initials: O
authors.lastname: Jokela
authors.forename: Taina
authors.initials: T
authors.lastname: Autti
mesh_terms: D000328:Adult; D001921:Brain / Q000187:drug effects* / Q000502:physiology / Q000503:physiopathology; D003344:Cortical Synchronization / Q000187:drug effects; D004569:Electroencephalography / Q000187:drug effects*; D005260:Female; D006801:Humans; D008297:Male; D008691:Methadone / Q000494:pharmacology* / Q000627:therapeutic use; D009294:Narcotics / Q000494:pharmacology* / Q000627:therapeutic use; D009293:Opioid-Related Disorders / Q000188:drug therapy / Q000503:physiopathology*; D009991:Oscillometry; D012016:Reference Values; D013375:Substance Withdrawal Syndrome / Q000188:drug therapy / Q000503:physiopathology*; D013997:Time Factors
chemical_list: D009294:Narcotics; D008691:Methadone