title: 2'-hydroxy-fendiline analogues as potent relaxers of isolated arteries.
abstract: Novel, 2'-hydroxy derivatives of fendiline have been synthesised and their ability to induce relaxation of isolated rat small mesenteric and coronary arteries were determined. Both derivatives examined were significantly more potent as vasodilators than fendiline itself. Similar effects were observed on both mesenteric and coronary arteries.
authors.affiliation: Centre for Drug Design, Biosciences Research Institute, Cockcroft Building, University of Salford, Salford M5 4WT, UK. j.a.wilkinson@salford.ac.uk
authors.forename: James
authors.initials: J
authors.lastname: Wilkinson
authors.forename: Dennis
authors.initials: D
authors.lastname: Foretia
authors.forename: Steven
authors.initials: S
authors.lastname: Rossington
authors.forename: Anthony
authors.initials: A
authors.lastname: Heagerty
authors.forename: John
authors.initials: J
authors.lastname: Leonard
authors.forename: Nigel
authors.initials: N
authors.lastname: Hussain
authors.forename: Clare
authors.initials: C
authors.lastname: Austin
mesh_terms: D000818:Animals; D001158:Arteries; D003331:Coronary Vessels / Q000187:drug effects* / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D005275:Fendiline / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology*; D008297:Male; D008638:Mesenteric Arteries / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013329:Structure-Activity Relationship; D014661:Vasoconstriction / Q000187:drug effects; D014665:Vasodilator Agents / Q000138:chemical synthesis / Q000494:pharmacology*
chemical_list: D014665:Vasodilator Agents; D005275:Fendiline