Brain metastasis in patients with esophageal carcinoma.
BACKGROUND
Brain metastasis from esophageal carcinoma is rare, and its natural history is unclear. To determine predictors for their outcomes, we conducted a retrospective review of patients.


METHODS
We treated 803 patients with metastatic brain tumors, and there were 17 patients with brain metastases from esophageal carcinoma. Their median age at the diagnosis was 57 years.


RESULTS
In the 15 patients with the pretreatment KPS of 70 or higher, the median survival after the diagnosis of brain metastasis was 26.2 months. Seven patients showed the median survival of 17.7 months after resection alone. The median survival was 65.5 months in the 3 patients who were treated with resection plus radiation.


CONCLUSIONS
Neurosurgical resection followed by WBRT seemed to be the indicated treatment in these patients.
Yoshida
Seiichi
S
Department of Neurosurgery, Niigata Cancer Center Hospital, Niigata 951-8566, Japan. brain@niigata-cc.jp
D000230:Adenocarcinoma / Q000401:mortality / Q000556:secondary* / Q000601:surgery; D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000401:mortality / Q000556:secondary* / Q000601:surgery; D002277:Carcinoma / Q000401:mortality / Q000556:secondary* / Q000601:surgery; D004938:Esophageal Neoplasms / Q000401:mortality / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D016609:Neoplasms, Second Primary / Q000473:pathology; D019635:Neurosurgical Procedures; D015996:Survival Rate