Synthesis, oligonucleotide incorporation and base pair stability of 7-methyl-8-oxo-2'-deoxyguanosine.
7-Methyl-8-oxo-2'-deoxyguanosine, an analogue of the abundant promutagen 8-oxo-2'-deoxyguanosine, was incorporated into oligonucleotides and tested for its stability in various base pairs.
Hamm
Michelle L
ML
Department of Chemistry, University of Richmond, Richmond, VA 23173, USA. mhamm@richmond.edu
Billig
Kelly
K
D020029:Base Pairing; D003849:Deoxyguanosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D006860:Hydrogen Bonding; D015394:Molecular Structure; D009841:Oligonucleotides / Q000737:chemistry*; D009943:Organophosphorus Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
C518278:7-methyl-8-oxo-2'-deoxyguanosine; D009841:Oligonucleotides; D009943:Organophosphorus Compounds; C434331:phosphoramidite; D003849:Deoxyguanosine