title: Acid-catalyzed synthesis of oxathiolone fused chalcones. Comparison of their activity toward various microorganisms and human cancer cells line.
abstract: Substituted oxathiolone fused chalcones were prepared by condensation of 4-acetyl-5-methoxy-2-oxo-benz[1,3]oxathiole with benzaldehydes under acidic conditions. The compounds were tested for cytotoxic, antibacterial, antifungal and tuberculostatic activity. Three derivatives demonstrated weak activity against HeLa cells, two were slightly active against Micrococcus luteus and Staphylococcus aureus, and one was active against Mycobacterium tuberculosis H(37)Rv.
authors.affiliation: Department of Organic Chemistry, Medical University of Gdańsk, Faculty of Pharmacy, Gdańsk, Poland. markon@amg.gda.pl
authors.forename: Marek T
authors.initials: MT
authors.lastname: Konieczny
authors.forename: Wojciech
authors.initials: W
authors.lastname: Konieczny
authors.forename: Michał
authors.initials: M
authors.lastname: Sabisz
authors.forename: Andrzej
authors.initials: A
authors.lastname: Skladanowski
authors.forename: Roland
authors.initials: R
authors.lastname: Wakieć
authors.forename: Ewa
authors.initials: E
authors.lastname: Augustynowicz-Kopeć
authors.forename: Zofia
authors.initials: Z
authors.lastname: Zwolska
mesh_terms: D000143:Acids / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002384:Catalysis; D047188:Chalcones / Q000138:chemical synthesis* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D006801:Humans; D008826:Microbial Sensitivity Tests; D013871:Thiones / Q000737:chemistry*
chemical_list: D000143:Acids; D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D047188:Chalcones; D013871:Thiones