Carcinoembryonic antigen-producing multiple myeloma detected by a transcription-reverse transcription concerted reaction system.
Multiple myeloma is a disease involving the clonal evolution of plasma cells that produce monoclonal immunoglobulin; however, other products, such as ammonia and amylase, reportedly are secreted by neoplastic plasma cells. We describe a patient with immunoglobulin A (IgA) myeloma who showed a high serum level of carcinoembryonic antigen (CEA) that correlated well with disease status and IgA level. We detected CEA-specific messenger RNA in plasma cells by means of a recently introduced rapid and quantitative RNA-amplification system, the transcription-reverse transcription concerted reaction system. This report is the first of a patient with a diagnosis of CEA-producing multiple myeloma.
Kaito
Ken
K
Central Clinical Laboratory, Jikei University Hospital, Tokyo, Japan. ken.kaito@jikei.ac.jp
Otsubo
Hiroko
H
Takahara
Shinobu
S
Hyouki
Miyuki
M
Abe
Masaki
M
Abe
Ikurou
I
Usui
Noriko
N
D000368:Aged; D002272:Carcinoembryonic Antigen / Q000096:biosynthesis*; D005260:Female; D006258:Head and Neck Neoplasms / Q000175:diagnosis / Q000378:metabolism*; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D009101:Multiple Myeloma / Q000175:diagnosis / Q000378:metabolism*; D020133:Reverse Transcriptase Polymerase Chain Reaction
D002272:Carcinoembryonic Antigen; D007070:Immunoglobulin A