Lung premalignancy induced by mutant B-Raf, what is thy fate? To senesce or not to senesce, that is the question.
Haigis
Kevin M
KM
Molecular Pathology Unit and Center for Cancer Research, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA.
Wistuba
Ignacio I
II
Kurie
Jonathan M
JM
D000818:Animals; D016922:Cellular Senescence / Q000235:genetics; D006801:Humans; D008175:Lung Neoplasms / Q000201:enzymology / Q000235:genetics* / Q000628:therapy; D020930:MAP Kinase Kinase Kinases / Q000037:antagonists & inhibitors / Q000378:metabolism; D051379:Mice; D009154:Mutation; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D011230:Precancerous Conditions / Q000201:enzymology / Q000235:genetics* / Q000628:therapy; D048493:Proto-Oncogene Proteins B-raf / Q000235:genetics* / Q000502:physiology
D019869:Phosphatidylinositol 3-Kinases; C482119:BRAF protein, human; C482120:Braf protein, mouse; D048493:Proto-Oncogene Proteins B-raf; D020930:MAP Kinase Kinase Kinases