title: Are the endothelial mechanisms of ACE-Is already established?
abstract: The endothelial mechanism of ACE-Is action is multifaceted. On the one hand, by inhibiting ACE, ACE-Is diminish Ang II synthesis, one of the best known active peptides. On the other hand, they modify synthesis and release of PGI(2) and NO via increasing production of other biologically important peptides like bradykinin, Ang-(1-7) or Ang-(1-9). Thus, ACE-Is play a crucial role in the function of endothelium and are effective and important tool for therapy of range of cardiovascular system disorders. Moreover, they are sensitive pharmacological instrument to elucidate and expand our knowledge about the role of RAS in human patophysiology.
authors.affiliation: Department of Pharmacodynamics, Medical University of Białystok, Mickiewicza 2C, PL 15-089 Białystok, Poland. pharmdyn@amb.edu.pl
authors.forename: Włodzimierz
authors.initials: W
authors.lastname: Buczko
authors.forename: Karol
authors.initials: K
authors.lastname: Kramkowski
authors.forename: Andrzej
authors.initials: A
authors.lastname: Mogielnicki
mesh_terms: D000804:Angiotensin II / Q000096:biosynthesis; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology*; D000818:Animals; D001920:Bradykinin / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000188:drug therapy* / Q000378:metabolism; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000378:metabolism; D011464:Epoprostenol / Q000378:metabolism; D006801:Humans; D009569:Nitric Oxide / Q000378:metabolism
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D000804:Angiotensin II; D009569:Nitric Oxide; D011464:Epoprostenol; D001920:Bradykinin