title: Nutritional assessment and serum zinc and copper concentration among children with acute lymphocytic leukemia: a longitudinal study.
abstract: OBJECTIVE
  When undergoing chemotherapy and/or radiotherapy, children with acute lymphocytic leukemia may present important nutritional disorders because of the gastrointestinal toxicity of most chemotherapy agents or the effects of radiation on the organism. These patients may also present changes in their serum concentrations of trace elements such as zinc and copper. The present study aimed to follow anthropometric parameters and serum levels of zinc and copper in a group of children under treatment for acute lymphocytic leukemia.
  
  
  METHODS
  Longitudinal study, at the Pediatric Section of Hospital das Clínicas, Ribeirão Preto, Brazil.
  
  
  METHODS
  Forty-five children with acute lymphocytic leukemia were studied. Anthropometric parameters such as weight and height and the daily intakes and serum levels of copper and zinc were recorded at diagnosis and during the treatment.
  
  
  RESULTS
  During the initial phase of the treatment, there was an increase in energy intake accompanied by weight gain. However, during the later phases of treatment there was a reduction in energy intake with accompanying weight loss. Decreased growth rate during treatment was more pronounced in children with high-risk acute lymphocytic leukemia, probably due to radiation therapy. Serum zinc levels remained basically unaltered during the treatment, whereas copper levels decreased dramatically with the beginning of treatment.
  
  
  CONCLUSIONS
  The treatment given to children with acute lymphocytic leukemia has an important effect on their linear growth rate and nutritional status, and also on their serum copper levels.
authors.affiliation: Pediatric Section, Hospital das Clínicas, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, São Paulo, Brazil. rsgarbieri@uol.com.br
authors.forename: Ursula Rohr
authors.initials: UR
authors.lastname: Sgarbieri
authors.forename: Mauro
authors.initials: M
authors.lastname: Fisberg
authors.forename: Luís Gonzaga
authors.initials: LG
authors.lastname: Tone
authors.forename: Maria do Rosário Dias
authors.initials: Mdo R
authors.lastname: Latorre
mesh_terms: D000886:Anthropometry; D000971:Antineoplastic Combined Chemotherapy Protocols; D049628:Body Size / Q000502:physiology; D002648:Child; D002675:Child, Preschool; D003300:Copper / Q000097:blood*; D002149:Energy Intake; D005260:Female; D006128:Growth / Q000187:drug effects*; D006801:Humans; D007223:Infant; D008137:Longitudinal Studies; D008297:Male; D015596:Nutrition Assessment; D009752:Nutritional Status; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000097:blood* / Q000188:drug therapy / Q000503:physiopathology; D012307:Risk Factors; D013997:Time Factors; D015032:Zinc / Q000097:blood*
chemical_list: D003300:Copper; D015032:Zinc