title: Favorable outcome for adolescents with acute lymphoblastic leukemia treated on Dana-Farber Cancer Institute Acute Lymphoblastic Leukemia Consortium Protocols.
abstract: OBJECTIVE
  Historically, adolescents with acute lymphoblastic leukemia (ALL) have had inferior outcomes when compared with younger children. We report the outcome of adolescents treated on Dana-Farber Cancer Institute (DFCI; Boston, MA) ALL Consortium Protocols conducted between 1991 and 2000.
  
  
  METHODS
  A total of 844 patients aged 1 to 18 years, with newly diagnosed ALL were enrolled onto two consecutive DFCI-ALL Consortium Protocols. We compared outcomes in three age groups: children aged 1 to 10 years (n = 685), young adolescents aged 10 to 15 years (n = 108), and older adolescents aged 15 to 18 years (n = 51).
  
  
  RESULTS
  With a median follow-up of 6.5 years, the 5-year event-free survival (EFS) for those aged 1 to 10 years was 85% (SE, 1%), compared with 77% (SE, 4%) for those aged 10 to 15 years, and 78% (SE, 6%) for those aged 15 to 18 years (P = .09). Adolescents were more likely to present with T-cell phenotype (P < .001) and less likely to have the TEL-AML1 fusion (P = .05). The incidence of pancreatitis and thromboembolic complications, but not asparaginase allergy, was higher in patients 10 years of age compared with those younger than 10 years. However, there was no difference in the rate of treatment-related complications between the 10- to 15-year and 15- to 18-year age groups.
  
  
  CONCLUSIONS
  Adolescents were more likely to present at diagnosis with biologically higher risk disease (T-cell phenotype and absence of the TEL-AML1 fusion) and more likely to experience treatment-related complications than younger children. However, the 5-year EFS for older adolescents was 78% +/- 6%, which is superior to published outcomes for similarly aged patients treated with other pediatric and adult ALL regimens. Based on this experience, we currently are piloting our regimen in patients aged 18 to 50 years.
authors.affiliation: Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA. elly_barry@dfci.harvard.edu
authors.forename: Elly
authors.initials: E
authors.lastname: Barry
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: DeAngelo
authors.forename: Donna
authors.initials: D
authors.lastname: Neuberg
authors.forename: Kristen
authors.initials: K
authors.lastname: Stevenson
authors.forename: Mignon L
authors.initials: ML
authors.lastname: Loh
authors.forename: Barbara L
authors.initials: BL
authors.lastname: Asselin
authors.forename: Ronald D
authors.initials: RD
authors.lastname: Barr
authors.forename: Luis A
authors.initials: LA
authors.lastname: Clavell
authors.forename: Craig A
authors.initials: CA
authors.lastname: Hurwitz
authors.forename: Albert
authors.initials: A
authors.lastname: Moghrabi
authors.forename: Yvan
authors.initials: Y
authors.lastname: Samson
authors.forename: Marshall
authors.initials: M
authors.lastname: Schorin
authors.forename: Harvey J
authors.initials: HJ
authors.lastname: Cohen
authors.forename: Stephen E
authors.initials: SE
authors.lastname: Sallan
authors.forename: Lewis B
authors.initials: LB
authors.lastname: Silverman
mesh_terms: D000293:Adolescent; D000367:Age Factors; D001215:Asparaginase / Q000009:adverse effects / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D050676:Core Binding Factor Alpha 2 Subunit / Q000235:genetics; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D015514:Oncogene Proteins, Fusion / Q000235:genetics; D010677:Philadelphia Chromosome; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy* / Q000235:genetics / Q000401:mortality; D000097764:ETS Translocation Variant 6 Protein
chemical_list: D001215:Asparaginase; D050676:Core Binding Factor Alpha 2 Subunit; D015514:Oncogene Proteins, Fusion; C102421:TEL-AML1 fusion protein; D000097764:ETS Translocation Variant 6 Protein