title: [Optimization of preparative technique for banxia-houpu effervescent tablets by orthogonal design].
abstract: OBJECTIVE
  To optimize preparative technique for banxia-houpu effervescent tablets.
  
  
  METHODS
  Based on the pH, disintegration time limited, taste, and rigidity of effervescent tablets, the proper proportion between citric acid and sodium bicarbonate, as well as the proper quantity of polyethylene glycol 6000 and sodium cyclamate in the effervescent tablets were determined by using orthogonal design. The content of magnolol and honokiol in effervescent tablets were measured by HPLC.
  
  
  RESULTS
  The optimal preparative technique was: cirtic acid: sodium bicarbonate = 0.65:1. The percentage of polyethylene glycol 6000 was 85%, and the percentage of sodium cyclamate was 1.0%.
  
  
  CONCLUSIONS
  The preparative technique is stable, reliable and suitable for practical use.
authors.affiliation: Department of Pharmaceutical Engineering, College of Biotechonlogy & Food Science, Tianjin University of Commerce, Tianjin 300134, China. zhping@tjcu.edu.cn
authors.forename: Ping
authors.initials: P
authors.lastname: Zheng
authors.forename: Wen-zhong
authors.initials: WZ
authors.lastname: Wang
authors.forename: Peng
authors.initials: P
authors.lastname: Zhang
authors.forename: Jian
authors.initials: J
authors.lastname: Han
authors.forename: Li-zhi
authors.initials: LZ
authors.lastname: Wu
mesh_terms: D001713:Biphenyl Compounds / Q000032:analysis; D002626:Chemistry, Pharmaceutical; D002851:Chromatography, High Pressure Liquid; D019343:Citric Acid / Q000008:administration & dosage; D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000302:isolation & purification; D006863:Hydrogen-Ion Concentration; D017705:Lignans / Q000032:analysis; D030021:Pinellia / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D011092:Polyethylene Glycols; D017693:Sodium Bicarbonate / Q000008:administration & dosage; D013607:Tablets; D013678:Technology, Pharmaceutical / Q000379:methods*; D000498:Allyl Compounds; D010636:Phenols
chemical_list: D001713:Biphenyl Compounds; D019343:Citric Acid; D004365:Drugs, Chinese Herbal; D017705:Lignans; D011092:Polyethylene Glycols; D017693:Sodium Bicarbonate; D013607:Tablets; C005498:magnolol; C005499:honokiol; D000498:Allyl Compounds; D010636:Phenols