Development of systemic arterial mechanical properties from infancy to adulthood interpreted by four-element windkessel models.
Aortic impedance data of infants, children and adults (age range 0.8-54 yr), previously reported by others, were interpreted by means of three alternative four-element windkessel models: W4P, W4S, and IVW. The W4P and W4S are derived from the three-element windkessel (W3) by connecting an inertance (L) in parallel or in series, respectively, with the aortic characteristic resistance (Rc). In the IVW, L is connected in series with a viscoelastic windkessel (VW). The W4S and IVW (same input impedance) fit the data best. The W4S, however, suffers from the assumption that Rc is part of total peripheral resistance (Rp). The IVW model offers a new paradigm for interpretation of resistive properties in terms of viscous (Rd) properties of vessel wall motion, distinguished from Rp. Results indicated that rapid reduction of Rd/Rp during early development is functional to modulation of decay time constant (taud) of pressure in diastole, such that normalization over heart period (taud/T) is independent of body size. Estimates of total arterial compliance (C) vs. age were fitted by a bell-shaped curve with a maximum at 33 yr. With body weight (BW) factored out by normalization, the C/BW data scattered about a bell-shaped curve centered at 66 mmHg. Inertance was significantly higher in pediatric patients than in adults, in accordance with a lower cross-sectional area of the vasculature, commensurate to a lower aortic flow. Changes of arterial properties appear functional to control the ratio of pulsatile power to active power and keep arterial efficiency as high as 97% in infants and children.
Burattini
Roberto
R
Department of Electromagnetics and Bioengineering, Polytechnic University of Marche, Via Brecce Bianche, 60131 Ancona, Italy. r.burattini@univpm.it
Di Salvia
Paola Oriana
PO
D000293:Adolescent; D000328:Adult; D000375:Aging / Q000502:physiology*; D001158:Arteries / Q000033:anatomy & histology / Q000254:growth & development / Q000502:physiology*; D001794:Blood Pressure; D001835:Body Weight; D002302:Cardiac Output; D002648:Child; D002675:Child, Preschool; D003187:Compliance; D017097:Electric Impedance; D006339:Heart Rate; D018056:Hemorheology; D006801:Humans; D007223:Infant; D008875:Middle Aged; D008955:Models, Cardiovascular; D011673:Pulsatile Flow; D012039:Regional Blood Flow; D015203:Reproducibility of Results; D013318:Stroke Volume; D014655:Vascular Resistance; D014783:Viscosity