title: Efficient solid-phase synthesis of a library of imidazo[1,2-a]pyridine-8-carboxamides.
abstract: A versatile method for the solid-phase synthesis of imidazo[1,2-a]pyridine-based derivatives, imidazo[1,2-a]pyridine-8-carboxamides, has been developed. They were obtained by treatment of the amino group of the polymer-bound 2-aminonicotinate with different alpha-haloketones, followed by halogenation at the 3-position of the polymer-bound imidazo[1,2-a]pyridine. The derived polymer-bound imidazo[1,2-a]pyridines 5, 6, and 7 were finally cleaved from the solid-support with an excess of primary or secondary amines. The final crude products were purified from excess amines by solid-supported liquid-liquid extraction (SLE).
authors.affiliation: Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500007, India. ahmedkamal@iict.res.in
authors.forename: Ahmed
authors.initials: A
authors.lastname: Kamal
authors.forename: V
authors.initials: V
authors.lastname: Devaiah
authors.forename: K Laxma
authors.initials: KL
authors.lastname: Reddy
authors.lastname: Rajendar
authors.forename: Rajesh V C R N C
authors.initials: RV
authors.lastname: Shetti
authors.forename: N
authors.initials: N
authors.lastname: Shankaraiah
mesh_terms: D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D011725:Pyridines / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D000577:Amides; D011725:Pyridines; C001439:imidazo(1,2-a)pyridine