title: Description of a neural sheath tumor of the trigeminal nerve: immunohistochemical and electron microscopy study.
abstract: BACKGROUND
  Malignant neural sheath tumors of the trigeminal nerve affecting the nasal cavity and the paranasal sinuses are extremely rare. With conventional optical microscopy, their identification is difficult, and it is necessary to confirm them by means of electron microscopy and immunohistochemical techniques.
  
  
  METHODS
  The patient was a 41-year-old woman with a ten-month progressive history of pain followed by painful edema in the left facial region, and with symptoms of bleeding, secretion and nasal obstruction. Studies with imaging methods suggested the presence of an expansive process in the left nasal and paranasal cavities. In the biopsy, the histopathological findings from optical microscopy were suggestive of a tumor of neural origin in the trigeminal nerve. Immunohistochemical and electron microscopy studies confirmed that it was a malignant tumor of the neural sheath of the trigeminal nerve. We describe the clinical, radiological, and histological features of this tumor and review the literature.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Khalili Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Bijan
authors.initials: B
authors.lastname: Khademi
authors.forename: Seied Mohammad
authors.initials: SM
authors.lastname: Owji
authors.forename: Khadije Jamshidi
authors.initials: KJ
authors.lastname: Khosh
authors.forename: Mohammad
authors.initials: M
authors.lastname: Mohammadianpanah
authors.forename: Behrooz
authors.initials: B
authors.lastname: Gandomi
mesh_terms: D000328:Adult; D001706:Biopsy; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008444:Maxillary Sinus Neoplasms / Q000473:pathology* / Q000628:therapy / Q000648:ultrastructure; D008854:Microscopy, Electron; D018317:Nerve Sheath Neoplasms / Q000473:pathology* / Q000628:therapy / Q000648:ultrastructure; D012509:Sarcoma / Q000473:pathology* / Q000628:therapy / Q000648:ultrastructure; D014057:Tomography, X-Ray Computed; D014276:Trigeminal Nerve / Q000473:pathology* / Q000648:ultrastructure