Six months of isoflavone supplement increases fat-free mass in obese-sarcopenic postmenopausal women: a randomized double-blind controlled trial.
OBJECTIVE
The aim of this study was to verify if six months of isoflavone supplementation could increase fat-free mass (FFM) and muscle mass index (MMI=appendicular FFM/height(2)) in obese-sarcopenic postmenopausal women.


METHODS
Double-blind randomized study.


METHODS
Eighteen sarcopenic-obese women completed the study (12 on isoflavones and six on placebo). Body composition was measured by dual-energy X-ray absorptiometry. Subjects ingested 70 mg of isoflavones per day (44 mg of diadzein, 16 mg glycitein and 10 mg genestein) or a placebo for 24 weeks.


RESULTS
The isoflavone group increased significantly appendicular (P=0.034), leg (P=0.016) FFM and MMI (P=0.037), but not the placebo group.


CONCLUSIONS
Six months of isoflavone supplementation increased FFM and MMI in obese-sarcopenic postmenopausal women.
Aubertin-Leheudre
M
M
Research Centre on Aging, Sherbrooke, Québec, Canada.
Lord
C
C
Khalil
A
A
Dionne
I J
IJ
D015502:Absorptiometry, Photon / Q000379:methods; D000368:Aged; D000375:Aging / Q000502:physiology; D001823:Body Composition / Q000187:drug effects*; D019587:Dietary Supplements; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007529:Isoflavones / Q000008:administration & dosage*; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000187:drug effects / Q000378:metabolism*; D009133:Muscular Atrophy / Q000188:drug therapy*; D009765:Obesity / Q000378:metabolism; D048789:Phytoestrogens / Q000008:administration & dosage*; D017698:Postmenopause; D016896:Treatment Outcome
D007529:Isoflavones; D048789:Phytoestrogens