title: Cryosurgery for resectable and unresectable hepatic metastases from colorectal cancer.
abstract: OBJECTIVE
  Hepatic cryosurgery is useful for patients with hepatic metastases from colorectal cancer confined to the liver but considered unresectables because of the number and location of lesions. While encouraging results were reported following cryosurgery for unresectable liver metastases we considered particularly valuable to examine the safety and effectiveness of cryosurgery in patients with resectable and unresectable metastases from colorectal cancer.
  
  
  METHODS
  Between January 1997 and September 2005, 53 patients with liver metastases from colorectal cancer underwent hepatic cryosurgery at our institution. Hepatic metastases were resectable in 31 (58.5%) patients and unresectable in 22 (41.5%).
  
  
  RESULTS
  A total of 136 liver metastases were treated in 53 patients. The size of treated lesions ranged from 0.5 to 10 cm (mean 2.7). There were 2 postoperative deaths (3.8%) from massive bleeding and from cryoshock. The overall morbidity rate was 66%. The median follow-up was 24.8 months. The overall survival rate at 12 months was 86.1%, at 48 months it was 27%. No significant difference was found between survival rates in patients with resectable or unresectable metastases. Among 31 patients with resectable liver metastases 7 (22.6%) patients developed recurrence at the site of cryosurgery.
  
  
  CONCLUSIONS
  Survival rates were comparables between patients with resectable and unresectable metastases but a high complication rate and a substantial rate of local recurrence following cryosurgery should caution against its use to treat resectable disease.
authors.affiliation: Department of General and Digestive Surgery, University Hospital of Saint-Etienne, Avenue Albert Raymond, 42055 Saint-Etienne Cedex 2, France. serban.bageacu@chu-st-etienne.fr
authors.forename: S
authors.initials: S
authors.lastname: Bageacu
authors.forename: D
authors.initials: D
authors.lastname: Kaczmarek
authors.forename: M
authors.initials: M
authors.lastname: Lacroix
authors.forename: J
authors.initials: J
authors.lastname: Dubois
authors.forename: J
authors.initials: J
authors.lastname: Forest
authors.forename: J
authors.initials: J
authors.lastname: Porcheron
mesh_terms: D000328:Adult; D000368:Aged; D015179:Colorectal Neoplasms / Q000473:pathology*; D003452:Cryosurgery / Q000009:adverse effects; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000401:mortality / Q000556:secondary* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D015996:Survival Rate