title: The association between residential pesticide use and cutaneous melanoma.
abstract: Occupational pesticide exposure has been linked to cutaneous melanoma in epidemiological studies. We studied the association between cutaneous melanoma and the residential use of pesticides. This is a case-control study of cutaneous melanoma (287 incident cases; 299 controls). Data on pesticide use was obtained with a standardised interview. An increased risk of melanoma was found for high use (4 times annually) of indoor pesticides (odds ratio (OR)=2.18; 95% confidence intervals (CI) 1.07-4.43) compared to low use (1 times annually), after adjustment for sex, age, education, sun exposure and pigmentary characteristics. Subjects exposed for 10 years or more had two and a half times the risk (OR=2.46; 95% CI 1.23-4.94) of those exposed for less than 10 years. A dose response was observed for the intensity of pesticides use (p(trend)=0.027). The results indicate that residential pesticide exposure may be an independent risk factor for cutaneous melanoma.
authors.affiliation: Clinical Epidemiology Unit, Istituto Dermopatico dell'Immacolata (IDI-IRCCS), Via dei Monti di Creta, 104, 00167 Rome, Italy. c.fortes@idi.it
authors.forename: Cristina
authors.initials: C
authors.lastname: Fortes
authors.forename: Simona
authors.initials: S
authors.lastname: Mastroeni
authors.forename: Franco
authors.initials: F
authors.lastname: Melchi
authors.forename: Maria Antonietta
authors.initials: MA
authors.lastname: Pilla
authors.forename: Massimo
authors.initials: M
authors.lastname: Alotto
authors.forename: Gianluca
authors.initials: G
authors.lastname: Antonelli
authors.forename: Diana
authors.initials: D
authors.lastname: Camaione
authors.forename: Simone
authors.initials: S
authors.lastname: Bolli
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Luchetti
authors.forename: Paolo
authors.initials: P
authors.lastname: Pasquini
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D004781:Environmental Exposure / Q000009:adverse effects*; D005260:Female; D006801:Humans; D015994:Incidence; D007558:Italy / Q000453:epidemiology; D008297:Male; D008545:Melanoma / Q000139:chemically induced* / Q000453:epidemiology; D008875:Middle Aged; D010575:Pesticides / Q000633:toxicity*; D012878:Skin Neoplasms / Q000139:chemically induced* / Q000453:epidemiology; D013471:Sunburn / Q000453:epidemiology; D013472:Sunlight / Q000009:adverse effects
chemical_list: D010575:Pesticides