title: Increasing incidence of type 1 diabetes in 0- to 17-year-old Colorado youth.
abstract: OBJECTIVE
  We sought to assess the long-term trends in the incidence of type 1 diabetes among non-Hispanic white and Hispanic youth aged 0-17 years from Colorado using data from the Colorado IDDM Study Registry (1978-1988) and SEARCH for Diabetes in Youth (2002-2004).
  
  
  METHODS
  Cases of diabetes were ascertained through physician reporting and hospital databases. Type 1 diabetes was defined as use of insulin within 2 weeks from diagnosis. Completeness of ascertainment was estimated as 97%. Annual average incidence rates (per 100,000/year) and 95% CIs for the time periods were computed. Trends in incidence were assessed by Poisson regression.
  
  
  RESULTS
  The incidence of type 1 diabetes was 14.8 (95% CI 14.0-15.6) in 1978-1988 and 23.9 (22.2-25.6) in 2002-2004 for the state of Colorado (P < 0.0001). From 1978 to 2004, the incidence of type 1 diabetes increased by 2.3% (1.6-3.1) per year (P < 0.0001). The increase in incidence was significant for both non-Hispanic white (2.7% [95% CI 1.9-3.6] per year, P < 0.0001) and Hispanic youth (1.6% [0.2-3.1] per year, P = 0.013).
  
  
  CONCLUSIONS
  The incidence of type 1 diabetes has increased 1.6-fold among Colorado youth from 1978-1988 to 2002-2004, and both non-Hispanic white and Hispanic youth are affected by this trend.
authors.affiliation: University of Colorado School of Medicine, Denver, Colorado, USA.
authors.forename: Kendra
authors.initials: K
authors.lastname: Vehik
authors.forename: Richard F
authors.initials: RF
authors.lastname: Hamman
authors.forename: Dennis
authors.initials: D
authors.lastname: Lezotte
authors.forename: Jill M
authors.initials: JM
authors.lastname: Norris
authors.forename: Georgeanna
authors.initials: G
authors.lastname: Klingensmith
authors.forename: Clifford
authors.initials: C
authors.lastname: Bloch
authors.forename: Marian
authors.initials: M
authors.lastname: Rewers
authors.forename: Dana
authors.initials: D
authors.lastname: Dabelea
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003120:Colorado / Q000453:epidemiology; D003922:Diabetes Mellitus, Type 1 / Q000453:epidemiology*; D005260:Female; D006630:Hispanic or Latino / Q000706:statistics & numerical data; D006801:Humans; D015994:Incidence; D007223:Infant; D008297:Male; D012042:Registries; D044465:White People / Q000706:statistics & numerical data