title: Effect of age on the development of a latanoprost-induced increase in iris pigmentation.
abstract: OBJECTIVE
  To study the effect of patient age on the incidence of latanoprost-induced increases in iris pigmentation.
  
  
  METHODS
  Prospective observational observer-masked study.
  
  
  METHODS
  Thirty-six patients younger than 60 years (group 1) and 36 patients older than 75 years (group 2) with primary open-angle glaucoma.
  
  
  METHODS
  We photographed both irises of each patient before and 6 months after unilateral latanoprost therapy. The basal iris colors were matched in both groups.
  
  
  METHODS
  Iris heterochromia identification at the 6-month evaluation of the photographs.
  
  
  RESULTS
  Twenty-eight patients (77.78%) in group 2 developed an increase in iris pigmentation compared with eight patients (22.22%) in group 1 (P = 0.0001, chi-square test).
  
  
  CONCLUSIONS
  Age seems to be an important risk factor for latanoprost-induced iris color change.
authors.affiliation: Vissum Hospital Oftalmológico Madrid, Madrid, Spain. e.arranzmarquez@gmail.com
authors.forename: Esther
authors.initials: E
authors.lastname: Arranz-Marquez
authors.forename: Miguel A
authors.initials: MA
authors.lastname: Teus
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging; D005127:Eye Color / Q000187:drug effects*; D005902:Glaucoma, Open-Angle / Q000188:drug therapy*; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D000077338:Latanoprost; D008875:Middle Aged; D011446:Prospective Studies; D011461:Prostaglandins F, Synthetic / Q000009:adverse effects* / Q000627:therapeutic use; D012307:Risk Factors; D016037:Single-Blind Method
chemical_list: D011461:Prostaglandins F, Synthetic; D000077338:Latanoprost