[Clinical and epidemiological analysis of possibility of acute myocardial infarction development in personnel of radiation dangerous plants].
According to the data of cohort and to the "case-control" studies, dynamics of an acute myocardial infarction (AMI) morbidity during the period 1998-2002 and role of radiation factor in AMI development among personnel of radiation dangerous plants (by the example of Siberian Group of Chemical Enterprises (SGCE) exposed to a long-term impact of ionizing radiation in the range of "low" doses) were being carried out. It was determined that in personnel of the main production (working in contact with IR sources) the gradient increase of AMI morbidity was registered during the study period. Personnel of the main production in comparison to personnel of support production (correlating age, sex and examination level) have statistically significant increase of standardized relative risk coefficients of AMI development. When evaluating standardized relative risk coefficient depending on the cumulative dose of external y-radiation, it was impossible to determine the reliance between the rate of increase of radiation dose and standardized relative risk coefficient. According to logistic regression, was determined that individual features of dose load formation are of great significance in AMI development for the personnel of the main production. Absolute values of standardized regression coefficients peculiar to the values characterizing technogenic impact, exceed correspondent values for "traditional" risk factors to be the components of the regression equation, two-three times as much. The combination of these factors allowed to prognosticate AMI development in 94.3% cases. Obtained data made possible to conclude that in pathogenesis of acute coronary diseases ionizing radiation acts as a factor that aggravate negative influence of "traditional" risk factors of cardio-vascular diseases through pleiotropic effects.
Karpov
A B
AB
Semenova
Iu V
IuV
Takhauov
R M
RM
Litvinenko
T M
TM
Leonov
V P
VP
D000328:Adult; D000367:Age Factors; D016022:Case-Control Studies; D002617:Chemical Industry; D002947:Cities; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000453:epidemiology*; D016273:Occupational Exposure; D011829:Radiation Dosage; D012044:Regression Analysis; D018570:Risk Assessment; D012426:Russia / Q000453:epidemiology; D013315:Stress, Psychological