A rapid and simple cleanup procedure for metathesis reactions.
[structure: see text]. A new method for easy removal of ruthenium from metathesis reactions by using a polar isocyanide is reported. This protocol removed most ruthenium byproducts from a variety of synthetically useful metatheses. Moreover, the isocyanide-promoted carbene insertion results in rapid destruction of carbene reactivity, demonstrated in the commonly used first- and second-generation Grubbs' carbenes.
Galan
Brandon R
BR
Department of Chemistry, University at Buffalo, The State University of New York, Amherst, NY 14260, USA.
Kalbarczyk
Kyle P
KP
Szczepankiewicz
Steven
S
Keister
Jerome B
JB
Diver
Steven T
ST