title: Neopeltolide, a macrolide from a lithistid sponge of the family Neopeltidae.
abstract: A new marine-derived macrolide designated as neopeltolide (1) has been isolated from a deep-water sponge of the family Neopeltidae. Its structure was elucidated on the basis of spectroscopic data interpretation. Neopeltolide (1) is a potent inhibitor of the in vitro proliferation of the A-549 human lung adenocarcinoma, the NCI-ADR-RES human ovarian sarcoma, and the P388 murine leukemia cell lines, with IC50's of 1.2, 5.1, and 0.56 nM, respectively. Neopeltolide (1) also inhibited the growth of the fungal pathogen Candida albicans with a minimum inhibitory concentration of 0.62 microg/mL.
authors.affiliation: Center for Ocean Exploration, Biomedical Marine Research Program, Harbor Branch Oceanographic Institution, Inc., 5600 US 1 North, Ft. Pierce, FL 34946, USA. wright@hboi.edu
authors.forename: Amy E
authors.initials: AE
authors.lastname: Wright
authors.forename: Julianne Cook
authors.initials: JC
authors.lastname: Botelho
authors.forename: Esther
authors.initials: E
authors.lastname: Guzmán
authors.forename: Dedra
authors.initials: D
authors.lastname: Harmody
authors.forename: Patricia
authors.initials: P
authors.lastname: Linley
authors.forename: Peter J
authors.initials: PJ
authors.lastname: McCarthy
authors.forename: Tara P
authors.initials: TP
authors.lastname: Pitts
authors.forename: Shirley A
authors.initials: SA
authors.lastname: Pomponi
authors.forename: John K
authors.initials: JK
authors.lastname: Reed
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020128:Inhibitory Concentration 50; D007941:Leukemia P388; D018942:Macrolides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D011161:Porifera / Q000737:chemistry* / Q000145:classification; D014407:Tumor Cells, Cultured
chemical_list: D000935:Antifungal Agents; D000970:Antineoplastic Agents; D018942:Macrolides; C519136:neopeltolide