title: [Seventy-five cases in which serum concentrations of cotinine were monitored prior to nicotine replacement therapy for smoking cessation].
abstract: We investigated the relationships between serum concentrations of cotinine and tests for nicotine dependence, exhaled carbon monoxide concentration, the urine concentration score of nicotine/cotinine/3-hydroxycotinine, cigarettes per day and cigarette index, in cases seeking medical advice in our hospital from April 2004 to November 2005. There was a significantly positive correlation between serum concentrations of cotinine and nicotine dependence, exhaled carbon monoxide concentration and the urine concentration score of nicotine/ cotinine/3-hydroxycotinine. In particular, the greatest positive correlation is between serum concentrations of cotinine and exhaled carbon monoxide concentration. There is no significant correlation between serum concentrations of cotinine and cigarettes per day and the cigarette index. To check exhaled carbon monoxide concentration is a useful index in nicotine replacement therapy for smoking cessation.
authors.affiliation: First Department of Medicine, Tokyo Women's Medical University.
authors.forename: Takao
authors.initials: T
authors.lastname: Tsuji
authors.forename: Atsushi
authors.initials: A
authors.lastname: Nagai
mesh_terms: D000328:Adult; D000368:Aged; D002248:Carbon Monoxide / Q000032:analysis; D003367:Cotinine / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009538:Nicotine / Q000378:metabolism; D016540:Smoking Cessation / Q000379:methods*; D015813:Substance Abuse Detection / Q000379:methods; D014029:Tobacco Use Disorder / Q000517:prevention & control
chemical_list: D009538:Nicotine; D002248:Carbon Monoxide; D003367:Cotinine