Ribosomal translocation: LepA does it backwards.
During translation, mRNA is threaded through the ribosome in precise and directional three-nucleotide steps. A recent paper identifies a new GTPase, LepA, which catalyzes unexpected one-codon backward movement on the ribosome.
Youngman
Elaine M
EM
Howard Hughes Medical Institute, Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
Green
Rachel
R
D003062:Codon / Q000235:genetics; D029968:Escherichia coli Proteins / Q000378:metabolism*; D006160:Guanosine Triphosphate / Q000378:metabolism; D008954:Models, Biological; D010448:Peptide Initiation Factors; D014176:Protein Biosynthesis / Q000502:physiology*; D012269:Ribosomal Proteins / Q000378:metabolism*; D012270:Ribosomes / Q000378:metabolism / Q000502:physiology*; D035602:Transcriptional Elongation Factors / Q000378:metabolism*
D003062:Codon; D029968:Escherichia coli Proteins; C515651:LepA protein, E coli; D010448:Peptide Initiation Factors; D012269:Ribosomal Proteins; D035602:Transcriptional Elongation Factors; D006160:Guanosine Triphosphate