The investigation of the pharmacokinetics of pulsatile-release salbutamol sulfate with pH-sensitive ion exchange resin as the carriers in beagle dogs.
We previously reported the preparation of the salbutamol sulfate pulsatile-release capsules with the pH-sensitive ion exchange resin as the carriers. In the present study, we investigated the pharmacokinetics of the salbutamol sulfate pulsatile-release capsules in beagle dogs. The analysis method was established for the drugs in vivo by HPLC method. The pharmacokinetics parameters of pulsatile-release salbutamol sulfate and reference tablet were AUC(0-24) (ng.h/ml) 1031.8+/-123.1, 1112.6+/-118.24, Cmax (ng/ml) 172.4+/-21.4, 179.3+/-26.1, Tmax (h) 3.8+/-0.6, 1.5+/-0.5, Tlag (h) 2.7+/-0.5, 0.3+/-0.2. The results showed that the test dosage forms was bioequivalent with reference dosage form, and had an obviously pulsatile-release effect.
Liu
Hongfei
H
Department of Pharmaceutics, Shen yang Pharmaceutical University, Shen yang, P.R. of China.
Sun
Tianhui
T
Yu
Feiqian
F
Zhao
Xin
X
Guo
Hong
H
Pan
Weisan
W
D000284:Administration, Oral; D000420:Albuterol / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D000818:Animals; D019540:Area Under Curve; D003692:Delayed-Action Preparations; D004285:Dogs; D004337:Drug Carriers / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D007475:Ion Exchange Resins / Q000737:chemistry*
D003692:Delayed-Action Preparations; D004337:Drug Carriers; D007475:Ion Exchange Resins; D000420:Albuterol