Photorefractive detection of tissue optical and mechanical properties by ultrasound modulated optical tomography.
Ultrasound-modulated optical tomography is a developing hybrid imaging modality that combines high optical contrast and good ultrasonic resolution for imaging soft biological tissue. We developed a photorefractive-crystal-based, time-resolved detection scheme with the use of a millisecond long ultrasound burst to image both the optical and the mechanical properties of biological tissues, with improved detection efficiency of ultrasound-tagged photons.
Xu
Xiao
X
Department of Biomedical Engineering, Texas A&M University, College Station 77843, USA.
Zhang
Huiliang
H
Hemmer
Philip
P
Qing
De-kui
DK
Kim
Chulhong
C
Wang
Lihong V
LV
D000818:Animals; D001696:Biomechanical Phenomena / Q000295:instrumentation / Q000379:methods; D004548:Elasticity; D004867:Equipment Design; D019544:Equipment Failure Analysis; D007089:Image Enhancement / Q000295:instrumentation / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000295:instrumentation* / Q000379:methods*; D051379:Mice; D019047:Phantoms, Imaging; D012031:Refractometry / Q000295:instrumentation* / Q000379:methods; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013314:Stress, Mechanical; D013623:Tail / Q000033:anatomy & histology* / Q000502:physiology*; D041622:Tomography, Optical / Q000295:instrumentation* / Q000379:methods; D014463:Ultrasonography / Q000295:instrumentation* / Q000379:methods