Immunogenicity of autologous immunoglobulins: principles and practices.
The immunogenicity of immunoglobulin idiotypes in syngeneic systems is a rather rare phenomenon. Very few studies have attempted to determine the mechanisms underlying the anti-idiotypic response that certain autologous idiotypes can elicit. Furthermore, the studies addressing a possible physiological role for such behaviors are even less. In the present article, the results of the characterization of a highly immunogenic idiotype are reviewed and compared with some related works on the subject. We finally propose a possible immunoregulatory role for idiotypic immunogenicity.
López-Requena
Alejandro
A
Department of Antibody Engineering, Center of Molecular Immunology, P.O. Box 16040, Havana 11600, Cuba. rolando@cim.sld.cu
Mateo De Acosta
Cristina
C
Vázquez
Ana María
AM
Pérez
Rolando
R
D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000276:immunology; D000911:Antibodies, Monoclonal; D000918:Antibody Specificity; D017951:Antigen Presentation; D001323:Autoantibodies; D006801:Humans; D007114:Immunization; D007126:Immunoglobulin Allotypes; D007140:Immunoglobulin Fab Fragments; D007130:Immunoglobulin Idiotypes / Q000276:immunology; D007136:Immunoglobulins / Q000276:immunology*
D000888:Antibodies, Anti-Idiotypic; D000911:Antibodies, Monoclonal; D001323:Autoantibodies; D007126:Immunoglobulin Allotypes; D007140:Immunoglobulin Fab Fragments; D007130:Immunoglobulin Idiotypes; D007136:Immunoglobulins