title: Plantar focal idiopathic hyperhidrosis and botulinum toxin: a pilot study.
abstract: Botulinum toxin is a safe and effective treatment for idiopatic focal axillary and palmar hyperhidrosis, but very few data are reported in the literature on its effect on plantar idiopatic hyperhidrosis. The current study was undertaken to investigate the impact of BTX-A administration on sweat production and quality of life in patients suffering from plantar hyperhidrosis. Ten patients with idiopathic, recalcitrant plantar hyperhidrosis were included in a pilot study and underwent intradermal injections with 100 MU of BTX-A in the plantar skin, bilaterally. All the patients were followed for 16 weeks after treatment with objective (Minor's test) and subjective (DLQI test) evaluation. Patients experienced an improvement of symptoms with a significant decrease of Minor's test and DLQI levels for 12 weeks. No significant side effects occurred in any treated patient. BTX-A seems to be a promising treatment for plantar hyperhidrosis. However, clinical trials on larger patient series are needed in order to evaluate its safety and effectiveness for this application.
authors.affiliation: Dermatological Clinic, Clinica Dermatologica, Ospedale Torrette, Via Conca 71, Ancona 60020, Italy. a.campanati@ao-umbertoprimo.marche.it
authors.forename: Anna
authors.initials: A
authors.lastname: Campanati
authors.forename: Maria Luisa
authors.initials: ML
authors.lastname: Bernardini
authors.forename: Rosaria
authors.initials: R
authors.lastname: Gesuita
authors.forename: Annamaria
authors.initials: A
authors.lastname: Offidani
mesh_terms: D019274:Botulinum Toxins, Type A / Q000627:therapeutic use*; D005260:Female; D005533:Foot Dermatoses / Q000188:drug therapy*; D006801:Humans; D006945:Hyperhidrosis / Q000188:drug therapy*; D008297:Male; D010865:Pilot Projects
chemical_list: D019274:Botulinum Toxins, Type A