Nanobacteria-associated calcific aortic valve stenosis.
Calcific aortic valve stenosis is the most common valvular disease in developed countries, and the major reason for operative valve replacement. In the US, the current annual cost of this surgery is approximately 1 billion dollars. Despite increasing morbidity and mortality, little is known of the cellular basis of the calcifications, which occur in high-perfusion zones of the heart. The case is presented of a patient with calcific aortic valve stenosis and colonies of progressively mineralized nanobacteria in the fibrocalcific nodules of the aortic cusps, as revealed by transmission electron microscopy. Consistent with their outstanding bioadhesivity, nanobacteria might serve as causative agents in the development of calcific aortic valve stenosis.
Jelic
Tomislav M
TM
Department of Pathology, Charleston Area Medical Center, West Virginia University, WV 25304, USA. tomislav.jelic@camc.org
Chang
Ho-Huang
HH
Roque
Rod
R
Malas
Amer M
AM
Warren
Stafford G
SG
Sommer
Andrei P
AP
D000369:Aged, 80 and over; D001024:Aortic Valve Stenosis / Q000382:microbiology* / Q000473:pathology; D001031:Apatites; D001424:Bacterial Infections / Q000150:complications / Q000473:pathology*; D002114:Calcinosis / Q000382:microbiology* / Q000473:pathology; D002130:Calcium Phosphates; D005260:Female; D006801:Humans; D046529:Microscopy, Electron, Transmission; D053758:Nanoparticles / Q000382:microbiology* / Q000648:ultrastructure
D001031:Apatites; D002130:Calcium Phosphates; C020243:calcium phosphate