title: Helicobacter pylori eradication in long-term proton pump inhibitor users in primary care: a randomized controlled trial.
abstract: BACKGROUND
  Two-thirds of proton pump inhibitor prescribing in the UK is for long-term therapy.
  
  
  OBJECTIVE
  To determine the impact of eradication in long-term proton pump inhibitor users infected with Helicobacter pylori.
  
  
  METHODS
  A total of 184 H. pylori-positive patients were randomly assigned to true or placebo eradication therapy. The primary outcome was the change in proton pump inhibitor usage measured by prescriptions; secondary outcomes were changes of proton pump inhibitor doses, dyspepsia symptoms, general practitioner consultations and quality of life measures.
  
  
  RESULTS
  In the year following H. pylori eradication proton pump inhibitor prescriptions fell compared with placebo (-1.7, 95% CI: -2.3 to -1.1, P < 0.001); when adjusted to full-dose equivalent prescriptions the reduction was more marked (-2.2, 95% CI: -3.0 to -1.4, P < 0.001). Both general practitioner consultations (-1.0, 95% CI: -1.8 to -0.1, P = 0.026) and symptoms measured on the Leeds Dyspepsia Questionnaire (-3.1, 95% CI: -5.3 to -0.9, P = 0.005) were reduced. Quality of life and self-rating measures also favoured eradication (EQ-5D: 0.09, P = 0.08 and VAS: 5.6, P = 0.002). The Carlsson and Dent Reflux Questionnaire found no difference between groups (-0.3, P = 0.65), possibly balancing decreased overall symptoms with increased prominence of heartburn in the eradication group.
  
  
  CONCLUSIONS
  Helicobacter pylori eradication in infected, long-term proton pump inhibitor users in primary care reduced both the overall severity of symptoms and use of health care.
authors.affiliation: School for Health, University of Durham, Queen's Campus, Wolfson Research Unit, University Boulevard, Stockton-on-Tees, UK. raghu@nath.freeserve.co.uk
authors.forename: A S
authors.initials: AS
authors.lastname: Raghunath
authors.forename: A P S
authors.initials: AP
authors.lastname: Hungin
authors.forename: J
authors.initials: J
authors.lastname: Mason
authors.forename: W
authors.initials: W
authors.lastname: Jackson
mesh_terms: D000368:Aged; D000658:Amoxicillin; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D004338:Drug Combinations; D004415:Dyspepsia / Q000188:drug therapy*; D004739:England; D005260:Female; D016481:Helicobacter Infections / Q000188:drug therapy*; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D008875:Middle Aged; D011320:Primary Health Care / Q000592:standards; D054328:Proton Pump Inhibitors
chemical_list: D000900:Anti-Bacterial Agents; D004338:Drug Combinations; D054328:Proton Pump Inhibitors; D000658:Amoxicillin