title: Phimosis and topical steroids: new clinical findings.
abstract: Phimosis has been defined as unretractable foreskin without adherences and/or a circular band of tight prepuce preventing full retraction. The aim of this study is to evaluate the efficacy (response rate) of topical steroids for the treatment of tight phimosis at different age stages. After using the same medication with different dosage schemes, a retrospective analysis was carried out to assess the efficacy of topical steroids in the treatment of tight phimosis. Patients were divided into three groups: group A (betamethasone scheme A), group B (betamethasone scheme B) and group C (control group). Remission of phimosis, with a complete exposure and without a narrowing behind the glans, was considered a complete response to treatment. The outcomes were then related to dosage scheme and patient's age. The dosage for group A was more effective than the dosage for groups B and C (control group). Phimosis resolved in 90% (group A), 72% (group B) and 56% (group C) of cases. A successful treatment was closely related to the age of patients at the beginning of steroid application. The results showed that treatment with topical steroids, which in general gives good results, proved to be much more successful in patients aged between 4 and 8 years, suggesting the efficacy of an early beginning of the treatment.
authors.affiliation: Department of Surgical Sciences, Paediatric Surgical Unit, University of Verona, Verona, Italy. dr.zampieri@libero.it
authors.forename: Nicola
authors.initials: N
authors.lastname: Zampieri
authors.forename: Michele
authors.initials: M
authors.lastname: Corroppolo
authors.forename: Veronica
authors.initials: V
authors.lastname: Zuin
authors.forename: Sanzio
authors.initials: S
authors.lastname: Bianchi
authors.forename: Francesco Saverio
authors.initials: FS
authors.lastname: Camoglio
mesh_terms: D000287:Administration, Topical; D000293:Adolescent; D001623:Betamethasone / Q000008:administration & dosage* / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D004334:Drug Administration Schedule; D004548:Elasticity / Q000187:drug effects; D005500:Follow-Up Studies; D052816:Foreskin / Q000187:drug effects / Q000503:physiopathology; D005938:Glucocorticoids / Q000008:administration & dosage* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D010688:Phimosis / Q000188:drug therapy* / Q000503:physiopathology; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D005938:Glucocorticoids; D001623:Betamethasone