Regulation of mitochondrial DNA content and cancer.
Enzymatic activities of the proteins encoded in nuclear genome are regulated by transcriptional, translational and post-transcriptional level. Enzymatic activities of proteins encoded in mitochondrial DNA (mtDNA) have been considered to be regulated by the same steps although detailed mechanisms might differ. However, dynamic change of the number of mtDNA, from some hundred to more than ten thousand, should be considered as another novel mechanism to regulate mtDNA-encoded proteins. Recently, we showed the connection of mtDNA depletion and deletion to cancer progression [Higuchi, M., Kudo, T., Suzuki, S., Evans, T.T., Sasaki, R., Wada, Y., Shirakawa, T., Sawyer, J.R., Gotoh, A., 2006. Mitochondrial DNA determines androgen dependence in prostate cancer cell lines. Oncogene 25, 1437-1445]. This review focuses and describes the possible connections of the mitochondrial DNA depletion and deletion to cancer.
Higuchi
Masahiro
M
Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, 4301 West Markham, Slot 516 Little Rock, AR 72205-7199, USA. mhiguchi@uams.edu
D000728:Androgens / Q000378:metabolism; D004272:DNA, Mitochondrial / Q000235:genetics* / Q000378:metabolism*; D018450:Disease Progression; D045222:Electron Transport Chain Complex Proteins / Q000235:genetics; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000235:genetics*; D011471:Prostatic Neoplasms / Q000235:genetics / Q000503:physiopathology
D000728:Androgens; D004272:DNA, Mitochondrial; D045222:Electron Transport Chain Complex Proteins