Graft-vs.-host disease in lung and other solid organ transplant recipients.
Graft-vs.-host disease (GVHD) is an uncommon complication of solid organ transplantation. Herein, we report a case of GVHD occurring in a lung transplant recipient and review 29 reported cases of GVHD that complicated thoracic organ, and non-hepatic intra-abdominal organ transplantation. The major presenting clinical symptom of GVHD was skin rash. Less frequent clinical manifestations were cytopenia (16%), diarrhea (11%), and fever (5%). The mainstay of treatment was high-dose corticosteroids. The mortality rate was high (30%). The cause of death was mainly due to infection, suggesting that antimicrobial prophylaxis may improve the outcome of this potentially fatal complication.
Assi
Maha A
MA
Division of Infectious Diseases, Department of Medicine, Mayo Clinic College of Medicine, Rochester, MN 55905, USA.
Pulido
Jose S
JS
Peters
Steve G
SG
McCannel
Colin A
CA
Razonable
Raymund R
RR
D000328:Adult; D006086:Graft vs Host Disease / Q000453:epidemiology*; D006801:Humans; D016040:Lung Transplantation / Q000009:adverse effects*; D008297:Male; D016377:Organ Transplantation / Q000009:adverse effects*; D011241:Prednisone / Q000627:therapeutic use; D016896:Treatment Outcome
D011241:Prednisone