[Microglia imaging].
Imaging of microglia cells using the radiolabeled ligand toward peripheral benzodiazepine receptor(PBR) is applied to brain injury and neurodegenerative diseases. A novel PBR radioligand other than [11C] PK11195 might be desirable to detailedly delineate this complicated phenomenon and a novel idea other than in vitro PBR binding ability is desirable to expect feasibility of a new candidate. Current status, problems and future prospects associated with indirect imaging of microglial activity with [11C] PK11195 will be discussed.
Hatano
Kentaro
K
Department of Brain Sciences and Molecular Imaging, National Institute for Longevity Sciences, National Center for Geriatrics and Gerontology.
D001930:Brain Injuries / Q000175:diagnosis; D003952:Diagnostic Imaging / Q000379:methods*; D006801:Humans; D017628:Microglia / Q000737:chemistry*; D025202:Molecular Diagnostic Techniques / Q000379:methods*; D019636:Neurodegenerative Diseases / Q000175:diagnosis; D018079:Receptors, GABA / Q000032:analysis; D011963:Receptors, GABA-A / Q000032:analysis*
D018079:Receptors, GABA; D011963:Receptors, GABA-A; C499229:TSPO protein, human