Conventional synthesis of amphiphilic block copolymer utilized for polymeric micelle by mechanochemical solid-state polymerization.
The first example is presented here of an amiphiphilic block copolymer synthesized by mechanochemical solid-state polymerization and used to form polymeric micelles. A model amphiphilic block copolymer was synthesized first, possessing galactose as a hydrophilic side chain and theophylline as a hydrophobic side chain, by mechanochemical solid-state polymerization. The resulting copolymer had a narrow molecular weight distribution. Polymeric micelle formation was subsequently carried out with the copolymer by a dialysis method. To gain insight into the physicochemical properties of the polymeric micelle, dynamic light scattering (DLS) measurements were performed. A narrow distribution of diameters was observed in the polymeric micelle solution, and these micelles were disrupted by the addition of sodium dodecyl sulfate (SDS). It was also confirmed by DLS measurements that the polymeric micelles were spherical. These results suggested that the block copolymer synthesized by mechanochemical solid-state polymerization was as suitable for the preparation of polymeric micelles as materials obtained by living polymerization.
Kondo
Shin-Ichi
S
Laboratory of Pharmaceutical Physical Chemistry, Gifu Pharmaceutical University, Gifu, Japan. skondo@gifu-pu.ac.jp
Mori
Hisato
H
Sasai
Yasushi
Y
Kuzuya
Masayuki
M
D001672:Biocompatible Materials / Q000138:chemical synthesis; D004337:Drug Carriers / Q000138:chemical synthesis*; D008027:Light; D008823:Micelles; D011108:Polymers / Q000737:chemistry*; D012542:Scattering, Radiation; D013501:Surface-Active Agents / Q000138:chemical synthesis*; D013806:Theophylline / Q000031:analogs & derivatives* / Q000737:chemistry
C520693:7-(2-(methacryloyloxy)ethylcarbamoyl)theophylline; D001672:Biocompatible Materials; D004337:Drug Carriers; D008823:Micelles; D011108:Polymers; D013501:Surface-Active Agents; D013806:Theophylline