Cardiomyocyte necrosis: alternative mechanisms, effective interventions.
Necrotic death of cardiac myocytes is a major contributor to heart failure associated with several cardiac pathologies such as ischemia and reperfusion injury. Preventing cardiomyocyte necrosis is an important challenge towards the development of effective strategies, aiming to battle cardiovascular disorders. While, necrotic cell death was traditionally considered a passive and chaotic process, emerging evidence indicates that specific molecular mechanisms underlie cellular destruction during necrosis. Elucidation of these mechanisms will facilitate therapeutic intervention against heart failure.
Tavernarakis
Nektarios
N
Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology, Vassilika Vouton, PO Box 1385, Heraklion 71110, Crete, Greece. tavernarakis@imbb.forth.gr
D000818:Animals; D006801:Humans; D008928:Mitochondria / Q000378:metabolism; D032383:Myocytes, Cardiac / Q000378:metabolism / Q000473:pathology*; D009336:Necrosis; D017382:Reactive Oxygen Species / Q000378:metabolism
D017382:Reactive Oxygen Species