title: Cytokines and chronic liver disease.
abstract: From an immunological point of view, the healthy liver has been usually associated with the phenomenon of tolerance. A microenvironment of regulatory cytokines produced by liver Kuppfer cells and liver sinusoidal endothelial cells has contributed, together with resident dendritic cells, to generate a tolerogenic environment in this tissue. In this review we discussed the intrahepatic responses to different sorts of liver injury, such as hepatotrophic viruses, alcohol or putative self-antigens. In each case we analyzed the impact of different cytokines in the clinical outcome of the different pathological situations.
authors.affiliation: Hospital de Clínicas José de San Martín, and Departamento de Microbiología, Parasitología e Inmunología, Facultad de Medicina, Universidad de Buenos Aires, Argentina. lfainboim@hospitaldeclinicas.uba.ar
authors.forename: Leonardo
authors.initials: L
authors.lastname: Fainboim
authors.forename: Alejandra
authors.initials: A
authors.lastname: Cherñavsky
authors.forename: Natalia
authors.initials: N
authors.lastname: Paladino
authors.forename: Ana C
authors.initials: AC
authors.lastname: Flores
authors.forename: Lourdes
authors.initials: L
authors.lastname: Arruvito
mesh_terms: D000818:Animals; D001324:Autoantigens / Q000276:immunology; D002908:Chronic Disease; D016207:Cytokines / Q000276:immunology*; D003713:Dendritic Cells / Q000276:immunology* / Q000473:pathology; D042783:Endothelial Cells / Q000276:immunology* / Q000473:pathology; D006507:Hepatovirus / Q000276:immunology; D006801:Humans; D007108:Immune Tolerance; D007728:Kupffer Cells / Q000276:immunology* / Q000473:pathology; D008099:Liver / Q000276:immunology / Q000293:injuries / Q000473:pathology; D008107:Liver Diseases / Q000276:immunology* / Q000473:pathology; D009928:Organ Specificity / Q000276:immunology
chemical_list: D001324:Autoantigens; D016207:Cytokines