title: Oxidative stress and mitochondrial dysfunction in neurodegenerative diseases.
abstract: In recent years, it has become increasingly clear that mitochondrial dysfunction and oxidative damage are major contributors to neuronal loss. Free radicals, typically generated from mitochondrial respiration, cause oxidative damage of nucleic acids, lipids, carbohydrates and proteins. Despite enormous amount of effort, however, the mechanism by which oxidative damage causes neuronal death is not well understood. Emerging data from a number of neurodegenerative diseases suggest that there may be common features of toxicity that are related to oxidative damage. In this review, while focusing on Huntington's disease (HD), we discuss similarities among HD, Friedreich ataxia and xeroderma pigmentosum, which provide insight into shared mechanisms of neuronal death.
authors.affiliation: Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
authors.forename: E
authors.initials: E
authors.lastname: Trushina
authors.forename: C T
authors.initials: CT
authors.lastname: McMurray
mesh_terms: D000818:Animals; D004249:DNA Damage / Q000235:genetics; D004734:Energy Metabolism / Q000235:genetics; D005621:Friedreich Ataxia / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D006816:Huntington Disease / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology; D008928:Mitochondria / Q000235:genetics / Q000378:metabolism*; D028361:Mitochondrial Diseases / Q000235:genetics / Q000503:physiopathology; D019636:Neurodegenerative Diseases / Q000235:genetics / Q000378:metabolism* / Q000503:physiopathology; D009474:Neurons / Q000378:metabolism*; D018384:Oxidative Stress / Q000502:physiology*; D014983:Xeroderma Pigmentosum / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology