Lipid transfer protein activities in subjects with impaired glucose tolerance.
BACKGROUND
Impaired glucose tolerance (IGT) is associated with an increased risk of atherosclerosis that may be due in part to dyslipidemia. The purpose of this study was to assess the regulatory role of lipid transfer proteins in the development of this dyslipidemia.


METHODS
Activities of cholesterol ester transfer protein (CETP) and phospholipid transfer protein (PLTP), as well as lipid and protein components of the major lipoprotein fractions, were evaluated in probands with IGT and were compared with those in subjects with normal glucose tolerance. The effect of a fat-rich meal on these variables was also investigated.


RESULTS
IGT probands had a higher triglyceride content in subfractions of low- (LDL) and high-density lipoprotein (HDL). IGT patients had higher fasting CETP activity. The latter was positively correlated with HDL2 triglycerides and negatively with HDL3 total cholesterol. PLTP activity and mass were not higher in IGT patients. However, PLTP activity correlated with components of VLDL and LDL and was influenced by the type of obesity. Neither CETP and PLTP activities nor PLTP mass were altered by a fat-rich meal. PLTP and CETP activities correlated in both fasting and postprandial conditions.


CONCLUSIONS
Increased fasting CETP activity may contribute to increased risk of atherosclerosis in subjects with IGT.
Julius
Ulrich
U
Medical Clinics and Outpatient Department III, University Hospital, Dresden, Germany. julius@rcs.urz.tu-dresden.de
Jauhiainen
Matti
M
Ehnholm
Christian
C
Pietzsch
Jens
J
D000293:Adolescent; D000328:Adult; D050197:Atherosclerosis / Q000209:etiology; D016022:Case-Control Studies; D053480:Cholesterol Ester Transfer Proteins / Q000097:blood*; D004032:Diet; D050171:Dyslipidemias / Q000150:complications / Q000378:metabolism*; D005215:Fasting; D018149:Glucose Intolerance / Q000150:complications / Q000378:metabolism*; D006801:Humans; D008074:Lipoproteins; D008875:Middle Aged; D049294:Phospholipid Transfer Proteins / Q000097:blood*; D019518:Postprandial Period
D053480:Cholesterol Ester Transfer Proteins; D008074:Lipoproteins; D049294:Phospholipid Transfer Proteins