Vitamin E metabolism.
The aim of this paper is to provide an overview of vitamin E metabolism. The topics covered include: major classes of vitamin E metabolites; their production pathways and route of excretion; possible biological activities of vitamin E metabolites; and use of vitamin E metabolites as markers of oxidant generation. Recent investigations into vitamin E metabolism have also highlighted important new areas of research, such as the potential for high dose vitamin E supplementation to interfere with drug metabolism, as well as alternative methods to alter vitamin E bioavailability in vivo. These issues will also be discussed in the review.
Wu
J H
JH
School of Medicine and Pharmacology, University of Western Australia, PO Box X2213, GPO Perth, WA 6847, Australia. jwu@meddent.uwa.edu.au
Croft
K D
KD
D000818:Animals; D002839:Chromans / Q000378:metabolism; D004347:Drug Interactions; D006801:Humans; D014810:Vitamin E / Q000031:analogs & derivatives / Q000097:blood / Q000737:chemistry / Q000378:metabolism*
D002839:Chromans; C483420:carboxyethyl-hydroxychroman; D014810:Vitamin E; C002421:tocopherylquinone