title: Six new triterpenoid saponins from the leaves of Ilex oblonga and their inhibitory activities against TMV replication.
abstract: Six new triterpenoid saponins of the ursane types were isolated from the MeOH extract of the leaves of Ilex oblonga. They were oblonganoside A (1), oblonganoside B (2), oblonganoside C (6), oblonganoside D (8), oblonganoside E (9), and oblonganoside F (10), together with three known triterpenoid saponins. The structures of these compounds were elucidated on the basis of spectroscopic analysis, and compound 1 showed appreciable inhibitory activity against TMV replication with EC50 value 0.074 mM.
authors.affiliation: Key Laboratory of Bio-pesticide and Chemistry-Biology, Ministry of Education, Fujian Agriculture and Forestry University, Fuzhou, Fujian, P.R.China.
authors.forename: Zu-Jian
authors.initials: ZJ
authors.lastname: Wu
authors.forename: Ming-An
authors.initials: MA
authors.lastname: Ouyang
authors.forename: Cong-Zhou
authors.initials: CZ
authors.lastname: Wang
authors.forename: Zheng-Kun
authors.initials: ZK
authors.lastname: Zhang
mesh_terms: D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology; D030017:Ilex / Q000737:chemistry*; D015394:Molecular Structure; D018515:Plant Leaves / Q000737:chemistry* / Q000821:virology; D012503:Saponins / Q000737:chemistry / Q000494:pharmacology*; D014026:Nicotiana / Q000821:virology; D014027:Tobacco Mosaic Virus / Q000187:drug effects*; D014315:Triterpenes / Q000737:chemistry / Q000494:pharmacology*; D014779:Virus Replication / Q000187:drug effects
chemical_list: D000998:Antiviral Agents; D012503:Saponins; D014315:Triterpenes