Preliminary results on interleukin-4 and interleukin-10 cytokine production in malnourished, inducible nitric oxide synthase-deficient mice with schistosomiasis mansoni infection.
Schistosoma mansoni infected C57Bl/6 inducible nitric oxide synthase (iNOS)-deficient and non-deficient malnourished mice, both fed a balanced controlled diet were studied. Interleukins, IL-4 and IL-10 responses to soluble egg antigens (SEA) 90 days after infection, were determined. Our results suggest that in iNOS deficient, malnourished mice, 90 days after of infection, nitric oxide has a downregulating effect on IL-4 and IL-10 production. We are currently investigating the biological significance of these findings.
Ramos
Renata P
RP
Laboratório de Bioquímica e Biologia Molecular, Departamento de Imunologia, Centro de Pesquisas Aggeu Magalhães-Fiocruz, 52020-020 Recife, PE, Brazil.
Costa
Vlaudia M A
VM
Melo
Camila F
CF
Souza
Valdênia M O
VM
Malagueño
Elizabeth
E
Coutinho
Eridan M
EM
Abath
Frederico G C
FG
Montenegro
Silvia M I
SM
D000818:Animals; D000947:Antigens, Helminth / Q000276:immunology; D004195:Disease Models, Animal; D016753:Interleukin-10 / Q000096:biosynthesis*; D015847:Interleukin-4 / Q000096:biosynthesis*; D008297:Male; D044342:Malnutrition / Q000276:immunology*; D051379:Mice; D008810:Mice, Inbred C57BL; D052247:Nitric Oxide Synthase Type II / Q000172:deficiency*; D010063:Ovum / Q000276:immunology; D012555:Schistosomiasis mansoni / Q000276:immunology*
D000947:Antigens, Helminth; D016753:Interleukin-10; D015847:Interleukin-4; D052247:Nitric Oxide Synthase Type II