Mitochondrial uncoupling protein 2 gene transcript levels are elevated in maturating erythroid cells.
Mitochondrial uncoupling protein 2 (UCP2) is abundant in developing monocyte/macrophage cells and may affect hematopoiesis by reducing formation of reactive oxygen species. The aims of this study were to further characterize the involvement of UCP2 in hematopoiesis. In situ hybridization in mouse embryos identified UCP2-positive cells in liver and inside primitive blood vessels from 10.5 days of prenatal development. High UCP2 transcript levels were detected in reticulocytes and other maturating erythroid cells in peripheral blood of mice exposed to hypoxia, and in umbilical cord blood of human neonates and peripheral blood of adults. Our results suggest involvement of UCP2 in erythropoiesis.
Flachs
Pavel
P
Department of Adipose Tissue Biology, Institute of Physiology, Academy of Sciences of the Czech Republic, Videnska 1083, 142 20 Prague, Czech Republic.
Sponarova
Jana
J
Kopecky
Pavel
P
Horvath
Ondrej
O
Sediva
Anna
A
Nibbelink
Maryse
M
Casteilla
Louis
L
Medrikova
Dasa
D
Neckar
Jan
J
Kolar
Frantisek
F
Kopecky
Jan
J
D000818:Animals; D016922:Cellular Senescence / Q000235:genetics*; D004622:Embryo, Mammalian; D041905:Erythroid Cells / Q000737:chemistry / Q000166:cytology*; D004920:Erythropoiesis / Q000235:genetics; D005312:Fetal Blood; D006801:Humans; D008099:Liver / Q000166:cytology; D051379:Mice; D011506:Proteins / Q000032:analysis / Q000235:genetics* / Q000502:physiology; D012333:RNA, Messenger / Q000032:analysis*; D012156:Reticulocytes / Q000737:chemistry
D011506:Proteins; D012333:RNA, Messenger; C035737:major urinary proteins