title: Hypoglycemic coma secondary to big insulin-like growth factor II secretion by a giant phyllodes tumor of the breast.
abstract: Nonislet cell tumor hypoglycemia (NICTH) is uncommon, and has been related to the production of insulin-like growth factor II or its high-molecular-weight precursor (big IGF-II) by the tumor. Cases of NICTH have been related to different tumors, mainly sarcomas. However, only three cases secondary to a phyllodes tumor of the breast (PTB) have been previously reported. We present the clinical course of a woman with a giant PTB, who developed an irreversible hypoglycemic coma secondary to big IGF-II production by the tumor. A brief review of the literature and possible mechanisms of this infrequent condition are also commented.
authors.affiliation: Servicio de Oncología Médica, Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, Spain. dagubuj@gobiernodecanarias.org
authors.forename: David
authors.initials: D
authors.lastname: Aguiar Bujanda
authors.forename: José Carlos
authors.initials: JC
authors.lastname: Rivero Vera
authors.forename: Miguel Angel
authors.initials: MA
authors.lastname: Cabrera Suárez
authors.forename: José
authors.initials: J
authors.lastname: Aguiar Morales
authors.forename: Rémy
authors.initials: R
authors.lastname: Christol
authors.forename: Uriel
authors.initials: U
authors.lastname: Bohn Sarmiento
authors.forename: Casimira
authors.initials: C
authors.lastname: Domínguez Cabrera
authors.forename: Yves
authors.initials: Y
authors.lastname: Le Bouc
mesh_terms: D001943:Breast Neoplasms / Q000378:metabolism*; D003128:Coma / Q000209:etiology*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007003:Hypoglycemia / Q000209:etiology*; D007335:Insulin-Like Growth Factor II / Q000378:metabolism*; D008875:Middle Aged; D003557:Phyllodes Tumor / Q000378:metabolism*; D011498:Protein Precursors / Q000378:metabolism*
chemical_list: D011498:Protein Precursors; C066038:proinsulin-like growth factor II; D007335:Insulin-Like Growth Factor II