Mismatch negativity contribution in multiple sclerosis patients.
Mismatch Negativity is a functional index of the supratemporal auditory cortex.


OBJECTIVE
The aim of the present study on Mismatch Negativity (MMN) in multiple sclerosis (MS) patients was to evaluate if the MMN can be correlated with cognitive deficits assessed by the Paced Auditory Addition Task--PASAT.


METHODS
a clinical study in forty females and 20 males separated in two groups: control individuals and those with a definite diagnosis of MS underwent a duration and frequency MMN. The MMN latencies and negative amplitudes obtained from the MS group were compared to the ones from the control group. The scores from the Paced Auditory Addition Task were correlated either with the presence or the absence of MMN.


RESULTS
MMN was found in 60% of the individuals with multiple sclerosis within the auditory stimulation protocol with varied durations, and in 45 % within the auditory stimulation protocol with frequency variations. There were no statistically significant differences in latencies and amplitudes when compared to controls. We found a statistically significant correlation for the lack of MMN wave together with cognitive disorder asserted by the PASAT.


CONCLUSIONS
The MMN correlated to the cognitive deficit assessed by the PASAT.
Santos
Marco Aurélio Rocha
MA
Programa de Pós-graduação em Otorrinolaringologia e Cirurgia de Cabeça em Pescoço, Escola Paulista de Medicina, Universidade Federal de São Paulo, SP.
Munhoz
Mário Sérgio Lei
MS
Peixoto
Marco Aurélio L
MA
Haase
Vitor Geraldi
VG
Rodrigues
Jussara L
JL
Resende
Luciana Macedo
LM
D000161:Acoustic Stimulation / Q000379:methods; D000328:Adult; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D003072:Cognition Disorders / Q000209:etiology; D003265:Contingent Negative Variation / Q000502:physiology*; D004569:Electroencephalography; D005071:Evoked Potentials / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000150:complications / Q000503:physiopathology*; D009483:Neuropsychological Tests; D011594:Psychometrics / Q000379:methods; D011930:Reaction Time