Evolutionary conservation of cell migration genes: from nematode neurons to vertebrate neural crest.
Because migratory cells in all animals share common properties, we hypothesized that genetic networks involved in cell migration may be conserved between nematodes and vertebrates. To explore this, we performed comparative genomic analysis to identify vertebrate orthologs of genes required for hermaphrodite-specific neuron (HSN) migration in Caenoryhabditis elegans, and then examined their expression and function in the vertebrate neural crest. The results demonstrate high conservation of regulatory components involved in long-range migrations across diverse species. Although the neural crest is a vertebrate innovation, the results suggest that its migratory properties evolved by utilizing programs already present in the common vertebrate-invertebrate ancestor.
Kee
Yun
Y
Division of Biology, California Institute of Technology, Pasadena, California 91125, USA.
Hwang
Byung Joon
BJ
Sternberg
Paul W
PW
Bronner-Fraser
Marianne
M
D000818:Animals; D017173:Caenorhabditis elegans / Q000235:genetics* / Q000502:physiology; D002465:Cell Movement / Q000235:genetics*; D019143:Evolution, Molecular; D015870:Gene Expression; D017238:Genes, Helminth; D023281:Genomics; D009348:Nematoda; D009432:Neural Crest / Q000166:cytology / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism* / Q000502:physiology