Light at the end of the tunnel? Advances in the understanding and treatment of glaucoma and inherited retinal degeneration.
Glaucoma and inherited retinal degeneration/dystrophy are leading causes of blindness in veterinary patients. Currently, there is no treatment for the loss of vision that characterizes both groups of diseases. However, this reality may soon change as recent advances in understanding of the disease processes allow researchers to develop new therapies aimed at preventing blindness and restoring vision to blind patients. Elucidating the molecular mechanisms of retinal ganglion cell death in glaucoma patients has led to the development of neuroprotective drugs which protect retinal cells and their function from the disastrous effects of elevated pressure. Identification of the genetic mutation responsible for inherited degenerations and dystrophies of the outer retina has enabled researchers using gene therapy to restore vision to blind dogs. Other patients may benefit from retinal transplantation, stem cell therapy, neuroprotective drugs, nutritional supplementation and even retinal prostheses. It is possible that soon it will be possible to restore sight to some blind patients.
Ofri
Ron
R
Koret School of Veterinary Medicine, Hebrew University of Jerusalem, P.O. Box 12, 76100 Rehovot, Israel. ofri@agri.huji.ac.il
Narfström
Kristina
K
D000818:Animals; D001766:Blindness / Q000517:prevention & control / Q000662:veterinary; D002371:Cat Diseases / Q000473:pathology / Q000628:therapy*; D002415:Cats; D004283:Dog Diseases / Q000473:pathology / Q000628:therapy*; D004285:Dogs; D005901:Glaucoma / Q000473:pathology / Q000628:therapy / Q000662:veterinary*; D006801:Humans; D012162:Retinal Degeneration / Q000473:pathology / Q000628:therapy / Q000662:veterinary*