title: Cognitive behavioural therapy for weight gain associated with antipsychotic drugs.
abstract: BACKGROUND
  Overweight and obesity are common concerns in individuals with severe mental disorders. In particular, antipsychotic drugs (AP) frequently induce weight gain. This phenomenon lacks current management and no previous controlled studies seem to use cognitive therapy to modify eating and weight-related cognitions. Moreover, none of these studies considered binge eating or eating and weight-related cognitions as possible outcomes.
  
  
  OBJECTIVE
  The main aim of this study is to assess the effectivity of cognitive and behavioural treatment (CBT) on eating and weight-related cognitions, binge eating symptomatology and weight loss in patients who reported weight gain during AP treatment.
  
  
  METHODS
  A randomized controlled study (12-week CBT vs. Brief Nutritional Education) was carried out on 61 patients treated with an antipsychotic drug who reported weight gain following treatment. Binge eating symptomatology, eating and weight-related cognitions, as well as weight and body mass index were assessed before treatment, at 12 weeks and at 24 weeks.
  
  
  RESULTS
  The CBT group showed some improvement with respect to binge eating symptomatology and weight-related cognitions, whereas the control group did not. Weight loss occurred more progressively and was greater in the CBT group at 24 weeks.
  
  
  CONCLUSIONS
  The proposed CBT treatment is particularly interesting for patients suffering from weight gain associated with antipsychotic treatment.
authors.affiliation: Department of Psychiatry, University Hospital of Vaud, Lausanne, Switzerland. yasser.khazaal@chuv.ch
authors.forename: Yasser
authors.initials: Y
authors.lastname: Khazaal
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Fresard
authors.forename: Sophie
authors.initials: S
authors.lastname: Rabia
authors.forename: Anne
authors.initials: A
authors.lastname: Chatton
authors.forename: Stephane
authors.initials: S
authors.lastname: Rothen
authors.forename: Valentino
authors.initials: V
authors.lastname: Pomini
authors.forename: François
authors.initials: F
authors.lastname: Grasset
authors.forename: François
authors.initials: F
authors.lastname: Borgeat
authors.forename: Daniele
authors.initials: D
authors.lastname: Zullino
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D015992:Body Mass Index; D052018:Bulimia Nervosa / Q000188:drug therapy* / Q000453:epidemiology; D003024:Clozapine / Q000627:therapeutic use*; D015928:Cognitive Behavioral Therapy / Q000379:methods*; D003131:Combined Modality Therapy; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D006266:Health Education; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000188:drug therapy* / Q000453:epidemiology; D015430:Weight Gain
chemical_list: D014150:Antipsychotic Agents; D003024:Clozapine