Cytomegalovirus vasculitis and mucormycosis coinfection in late-stage HIV/AIDS.
Case reports have previously been published describing various complications of cytomegalovirus (CMV) and mucormycosis in patients with HIV/AIDS. We describe the first case of CMV vasculitis and mucormycosis coinfection resulting in necrotizing myofascial cellulitis in an extremity in late stage HIV/AIDS. In AIDS patients, CMV reactivates when the CD4 count falls to less than 50 cells/microL (normal, 720-1440 cells/microL). Transient episodes of neutropenia in patients with HIV/AIDS who have low CD 4 cell counts are a predisposing factor for mucormycosis. These predisposing conditions were both present in our patient. Our case raises the question of CMV vasculitis leading to tissue ischemia as a possible contributing factor to the mucormycosis superinfection.
Samant
Jyoti S
JS
Department of Internal Medicine, Section of Infectious Diseases, Mercer University, School of Medicine, Macon, Georgia 31201, USA. jsamant@hotmail.com
Namgoong
Soo H
SH
Parveen
Talat
T
Katner
Harold P
HP
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000328:Adult; D003587:Cytomegalovirus; D003586:Cytomegalovirus Infections / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008297:Male; D009091:Mucormycosis / Q000150:complications / Q000175:diagnosis*; D012867:Skin / Q000473:pathology; D014657:Vasculitis / Q000150:complications / Q000175:diagnosis* / Q000821:virology*