Hypothyroidism in coronary heart disease and its relation to selected risk factors.
BACKGROUND
Hypothyroidism (HT) has been found a predictor of cardiovascular diseases. We aimed to ascertain the prevalence of HT in patients with manifest coronary heart disease (CHD), and to establish its association with conventional risk factors.


METHODS
410 patients, 6-24 months after hospitalization for acute coronary syndrome, and/or revascularization, were included into the cross-sectional study.


RESULTS
The prevalence of thyroid dysfunction was found in males and females as follows: overt HT, ie, thyroid stimulating hormone (TSH) > 3.65 mIU/L and free thyroxine (fT4) < 9 pmol/L and/or L-thyroxine substitution, in 2.6% and 8.4%, respectively; subclinical HT (TSH > 3.65, fT4 9-23 and no substitution) in 4.3% and 15.0%, respectively. Higher prevalence of HT was found in females with hypercholesterolemia, and in males and females with concomitant positive thyroid peroxidase antibodies. Hypothyroid subjects had higher total homocysteine in both genders and von Willebrand factor in males only. Hypothyroid females had higher total and LDL cholesterol, and were more often treated for diabetes.


CONCLUSIONS
HT was found highly prevalent in patient with clinical coronary heart disease, mainly in females, and was associated with several cardiovascular risk factors.
Mayer
Otto
O
Center of Preventive Cardiology, 2nd Department of Internal Medicine, Charles University, Medical Faculty, Plzen, Czech Republic. mayerjr@lfp.cuni.cz
Simon
Jaroslav
J
Filipovský
Jan
J
Plásková
Markéta
M
Pikner
Richard
R
D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000097:blood; D001324:Autoantigens / Q000276:immunology; D003327:Coronary Disease / Q000209:etiology*; D003430:Cross-Sectional Studies; D018153:Czech Republic / Q000453:epidemiology; D005260:Female; D006710:Homocysteine / Q000097:blood; D006801:Humans; D006937:Hypercholesterolemia / Q000150:complications / Q000453:epidemiology; D007037:Hypothyroidism / Q000097:blood / Q000150:complications* / Q000453:epidemiology*; D007453:Iodide Peroxidase / Q000276:immunology; D033862:Iron-Binding Proteins / Q000276:immunology; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D015995:Prevalence; D012307:Risk Factors; D012720:Severity of Illness Index; D017678:Sex Distribution; D012737:Sex Factors; D013972:Thyrotropin / Q000097:blood; D013997:Time Factors; D014841:von Willebrand Factor / Q000378:metabolism
D001323:Autoantibodies; D001324:Autoantigens; D033862:Iron-Binding Proteins; D014841:von Willebrand Factor; D006710:Homocysteine; D013972:Thyrotropin; C056658:TPO protein, human; D007453:Iodide Peroxidase