[Effects of Jujingwan on nitric oxide and superoxide dismutase in seminal plasma of asthenospermia patients].
OBJECTIVE
To explore the possible action mechanism of Jujingwan on asthenospermia.


METHODS
Semen routine analyses and determination of nitric oxide (NO) concentration and superoxide dismutase (SOD) activity in seminal plasma were performed in 34 cases of asthenospermia. The changes of NO concentration and SOD activity before and after the treatment with Jujingwan were observed.


RESULTS
Compared with pre-treatment, there was no significant change in NO concentration, and the activity of SOD decreased significantly after the treatment ([95.97 +/- 20.75] microg/L vs [6.14 +/- 19.99] microg/L). There was negative correlation between NO concentration and SOD activity before the treatment (r = -0.246, P < 0.05).


CONCLUSIONS
Jujingwan can significantly improve sperm viability in patients with asthenospermia. However, the excellent effects of Jujingwan are not displayed in the changes of NO concentration and SOD activity.
Jin
Bao-fang
BF
Laboratory of Reproduction & Genetics, PIA Institute of Clinical Laboratory Medicine, Nanjing General Hospital of Nanjing Command, PLA, Nanjing, Jiangsu, China. hexiking@126.com
Yang
Xiao-yu
XY
Bian
Ting-song
TS
Zhou
Xiang
X
Huang
Yu-feng
YF
Wang
Xiu-lai
XL
Zhou
Zuo-min
ZM
Xu
Fu-song
FS
D000328:Adult; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000378:metabolism*; D009845:Oligospermia / Q000188:drug therapy* / Q000378:metabolism; D008517:Phytotherapy; D012661:Semen / Q000737:chemistry*; D013076:Sperm Count; D013081:Sperm Motility / Q000187:drug effects; D013482:Superoxide Dismutase / Q000378:metabolism*
D004365:Drugs, Chinese Herbal; D009569:Nitric Oxide; D013482:Superoxide Dismutase