[Newborn infants supported by extracorporeal membrane oxygenation: survival and clinical outcome].
OBJECTIVE
To assess the prognosis of newborn infants with refractory hypoxemia who required extracorporeal membrane oxygenation (ECMO).


METHODS
Eighty-nine newborn infants treated by ECMO during more than 24 hours over a 8-year period (1996-2003) were included in this observational cohort study with a 9-month and 24-month evaluation.


RESULTS
Respiratory failure mainly resulted from meconium aspiration syndrome (MAS, 43%), congenital diaphragmatic hernia (CDH, 15%) and sepsis (15%). Overall survival at hospital discharge was 67%. Infants with MAS had the best survival rate (82%) and those with CDH had the worst (46%). Of the remaining 60 survivors, 53% remained oxygen dependent at 28 days and 33% at 45 days. At the age of 2 years, only 1 infant remained oxygen dependent (but did not required oxygen at 3 years) and only 3 infants had significant neurodevelopmental problems. CDH group was associated with a prolonged duration in supplementary oxygen (P<0.001) and a prolonged duration for tube feeding (P=0.01) as compared with other diagnoses. Regarding neurologic outcome, CDH infants had the poorer neurological acquisition rate at 9 months but a very good evolution by the time of the 24-month evaluation.


CONCLUSIONS
Morbidity in ECMO survivors is low considering the severity of illness in the newborn period, mainly related to pulmonary and feeding dysfunctions during the first months, in particular for the CDH group. Outcome at the age of 2 years of CDH infants is most often favourable regarding growth and neurodevelopmental evolution.
Flamant
C
C
Service de réanimation néonatale et pédiatrique, Assistance publique-Hôpitaux de Paris, hôpital d'enfants Armand-Trousseau, 26 avenue du Docteur-A.-Netter, 75571 Paris cedex 12, France. cyril.flamant@trs.aphp.fr
Lorino
E
E
Nolent
P
P
Hallalel
F
F
Chevalier
J-Y
JY
Fau
S
S
Gold
F
F
Renolleau
S
S
D002675:Child, Preschool; D015331:Cohort Studies; D002658:Developmental Disabilities / Q000209:etiology; D015199:Extracorporeal Membrane Oxygenation / Q000401:mortality*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D000860:Hypoxia / Q000209:etiology / Q000401:mortality* / Q000628:therapy*; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D017063:Outcome Assessment, Health Care; D012127:Respiratory Distress Syndrome, Newborn / Q000209:etiology / Q000401:mortality* / Q000628:therapy*; D012131:Respiratory Insufficiency / Q000209:etiology / Q000401:mortality* / Q000628:therapy*; D016019:Survival Analysis; D015300:Ventilator Weaning