Reverse interactomics: from peptides to proteins and to functions.
Identifying associated partners is critical to understanding the potential function and upstream and downstream pathways of the molecule being studied. The Src homology 2 (SH2) domain is a binding module for peptides containing a phosphotyrosine residue, which is a post-translational modification that is heavily involved in signal transduction. A paper in this issue shows how "reverse interactomics" can be exploited to identify binding partners of the SH2 domain of tensin.
Lo
Su Hao
SH
Lawrence Ellison Center for Tissue Regeneration and Repair, Department of Orthopaedic Surgery, Cancer Center, University of California-Davis, Sacramento, California 95817, USA. shlo@ucdavis.edu
D000818:Animals; D006801:Humans; D008840:Microfilament Proteins / Q000378:metabolism; D010455:Peptides / Q000378:metabolism*; D011485:Protein Binding; D011506:Proteins / Q000378:metabolism*; D000070876:Tensins; D018909:src Homology Domains
D008840:Microfilament Proteins; D010455:Peptides; D011506:Proteins; D000070876:Tensins