Transient splenial lesion of the corpus callosum after acute withdrawal of antiepileptic drug: a case report.
Transient lesions at the splenium of the corpus callosum (SCC) have been reported after withdrawal of specific antiepileptic drugs (AED), though the pathophysiology of the lesions remains unclear. We examined and treated a schizophrenic patient who developed a transient SCC lesion after withdrawal of the AED, carbamazepine. Interestingly, the SCC lesion was accompanied by the onset of diabetes insipidus, a state of arginine-vasopressin (AVP) insufficiency. Because carbamazepine is shown to potentiate the effect of AVP, our case suggests that an insufficiency of AVP followed by withdrawal of AED could contribute to the pathogenesis of a transient SCC lesion.
Honda
Kazuhiro
K
Department of Neurology, Kohnodai Hospital, National Center of Neurology and Psychiatry, Chiba, Japan.
Nishimiya
Jin
J
Sato
Hideki
H
Munakata
Maki
M
Kamada
Masaki
M
Iwamura
Akihide
A
Nemoto
Hideaki
H
Sakamoto
Takashi
T
Yuasa
Tatsuhiko
T
D000208:Acute Disease; D000927:Anticonvulsants / Q000009:adverse effects; D001927:Brain Diseases / Q000139:chemically induced* / Q000175:diagnosis*; D002220:Carbamazepine / Q000009:adverse effects*; D003337:Corpus Callosum / Q000187:drug effects* / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D013375:Substance Withdrawal Syndrome / Q000175:diagnosis*; D013997:Time Factors
D000927:Anticonvulsants; D002220:Carbamazepine