title: Dynamic change of proximal conduction in demyelinating neuropathies: a cervical magnetic stimulation combined with maximum voluntary contraction.
abstract: OBJECTIVE
  To evaluate conduction abnormalities in the nerves innervating the proximal muscles in demyelinating neuropathies (DN) using cervical magnetic stimulation.
  
  
  METHODS
  We applied cervical root magnetic stimulation in the biceps brachii muscles and examined its activity-dependent conduction changes produced by maximal voluntary contraction (MVC) in 12 DN patients (seven chronic inflammatory demyelinating polyradiculoneuropathy and five multifocal motor neuropathy), six motor neuron disease (MND) patients, and 12 healthy volunteers.
  
  
  RESULTS
  Defining the upper normal limit of motor threshold (31%) and latency (6.7 ms) of the compound muscle action potential (CMAP) as mean+2SD, most DN patients revealed an abnormality in motor threshold (10/12) and latency (11/12) in contrast to MND patients (motor threshold (1/6) and latency (0/6)). These parameters contribute to the differentiation of DN from MND (P<0.01). Furthermore, the MVC maneuver transiently decreased the CMAP amplitude ratio (after MVC/before MVC x 100) in DN (83+/-18 %) compared with MND (P<0.01). Two of three DN patients who showed normal motor threshold or latency as in MND were successfully differentiated from MND by the MVC maneuver.
  
  
  CONCLUSIONS
  In DN patients, conduction abnormality in the nerves innervating the proximal muscles was revealed by cervical magnetic stimulation combined with the MVC maneuver.
  
  
  CONCLUSIONS
  Our results suggested that conduction abnormalities in the proximal nerves innervating the proximal muscles could be evaluated by this method.
authors.affiliation: Department of Neurology, Kyoto University Hospital, Japan.
authors.forename: Takefumi
authors.initials: T
authors.lastname: Hitomi
authors.forename: Ryuji
authors.initials: R
authors.lastname: Kaji
authors.forename: Nagako
authors.initials: N
authors.lastname: Murase
authors.forename: Nobuo
authors.initials: N
authors.lastname: Kohara
authors.forename: Takahiro
authors.initials: T
authors.lastname: Mezaki
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Nodera
authors.forename: Takashi
authors.initials: T
authors.lastname: Kawamura
authors.forename: Akio
authors.initials: A
authors.lastname: Ikeda
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Shibasaki
mesh_terms: D000328:Adult; D000368:Aged; D004307:Dose-Response Relationship, Radiation; D004558:Electric Stimulation / Q000379:methods*; D019054:Evoked Potentials, Motor / Q000187:drug effects / Q000502:physiology; D005260:Female; D006801:Humans; D008280:Magnetics; D008297:Male; D008875:Middle Aged; D016472:Motor Neuron Disease / Q000503:physiopathology; D009119:Muscle Contraction / Q000502:physiology / Q000528:radiation effects*; D018482:Muscle, Skeletal / Q000503:physiopathology / Q000528:radiation effects*; D009431:Neural Conduction / Q000502:physiology / Q000528:radiation effects*; D020277:Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / Q000503:physiopathology*; D011930:Reaction Time / Q000502:physiology / Q000528:radiation effects