[Study of quantification of oxidative stresses caused by lifestyle habits].
It is now clear that oxidative stresses caused by reactive oxygen species, free radicals originating in them, and lipid peroxides can be factors to cause over 90% of lifestyle-related diseases including cancer, heart diseases, cerebrovascular diseases, arteriosclerosis, hypertension, and diabetes mellitus. In the present study, health conditions, nutrition intake, bodily activities, smoking/non-smoking, and sleep hours among other factors were surveyed with youths around twenty years old of age as subjects, and those results and the results of measurement of speed for the generation of 8-OHdG (8-Hydroxy-2'-Deoxyguanosine) as oxidative stress biomarker were compared for consideration. As a result, there were correlations detected as to exercise habits, cholesterol values, and smoking habits. It was also clarified that oxidative stresses decrease by continuing taking constant aerobic exercises or by quitting smoking or reducing the numbers of cigarettes to smoke. Thereby, it was suggested that the measurement of speed for the generation of 8-OHdG can provide an indicator that is useful as an integrated evaluation to improve lifestyle habits that are to be understood to induce lifestyle-related diseases.
Mimura
Kunihiro
K
Division of Clinical Laboratory Science, Faculty of Risk and Crisis Management, Chiba Institute of Science, Choshi.
Kobayashi
Takayuki
T
Mizukoshi
Satoko
S
D000080242:8-Hydroxy-2'-Deoxyguanosine; D000328:Adult; D015415:Biomarkers / Q000032:analysis; D003849:Deoxyguanosine / Q000031:analogs & derivatives* / Q000032:analysis; D015444:Exercise / Q000502:physiology; D005260:Female; D006801:Humans; D008019:Life Style; D008297:Male; D018384:Oxidative Stress; D012907:Smoking / Q000009:adverse effects
D015415:Biomarkers; D000080242:8-Hydroxy-2'-Deoxyguanosine; D003849:Deoxyguanosine