title: First epidemiological data from the French Trophoblastic Disease Reference Center.
abstract: OBJECTIVE
  The objective of the study was to describe women registered at the new French Trophoblastic Disease Reference Center and particularly the rates of gestational trophoblastic neoplasia (GTN) after molar pregnancies.
  
  
  METHODS
  Epidemiological data from a prospective cohort of women registered between November 1999 and November 2004 were analyzed.
  
  
  RESULTS
  Four hundred forty-eight women were registered. The referent pathologist reclassified 32% and 5% of assumed partial mole (PM) and complete mole (CM), respectively. GTN developed in 30 of 212 patients with singleton CM (14%) and in 5 of 108 with singleton PM (5%). Among 131 patients with GTN (35 women followed up after registration for a mole and 96 registered for a GTN), 115 (88%) were low-risk and 16 (12%) were high-risk patients according to 2000 International Federation of Gynecology and Obstetrics (FIGO) scoring system.
  
  
  CONCLUSIONS
  Creation of trophoblastic disease reference centers is desirable to improve treatment of patients. Our results will have to be compared with future publications based on the new 2000 FIGO oncology committee recommendations.
authors.affiliation: Hospices Civils de Lyon, Hôtel-Dieu, Centre de Référence des Maladies Trophoblastiques, Lyon, France. francois.golfier@chu-lyon.fr
authors.forename: François
authors.initials: F
authors.lastname: Golfier
authors.forename: Daniel
authors.initials: D
authors.lastname: Raudrant
authors.forename: Lucien
authors.initials: L
authors.lastname: Frappart
authors.forename: Bruno
authors.initials: B
authors.lastname: Mathian
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Guastalla
authors.forename: Véronique
authors.initials: V
authors.lastname: Trillet-Lenoir
authors.forename: Fabien
authors.initials: F
authors.lastname: Vaudoyer
authors.forename: Touria
authors.initials: T
authors.lastname: Hajri
authors.forename: Anne-Marie
authors.initials: AM
authors.lastname: Schott
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D005602:France; D031901:Gestational Trophoblastic Disease / Q000453:epidemiology / Q000209:etiology; D006782:Hospitals, Special / Q000706:statistics & numerical data*; D006801:Humans; D006828:Hydatidiform Mole / Q000150:complications*; D008875:Middle Aged; D011247:Pregnancy; D011446:Prospective Studies; D014328:Trophoblastic Neoplasms / Q000453:epidemiology*; D014594:Uterine Neoplasms / Q000453:epidemiology*