Heart rate variability in the fetus: a comparison of measures.
BACKGROUND
In fetal surveillance, fetal heart rate changes are assessed using cardiotocography (CTG). Standard procedures used in the quantification of heart rate variability (HRV) are seldom applied as CTG does not deliver beat interval durations with the same accuracy as the electrocardiogram (ECG). Thus little is known about the interdependency of standard HRV measures prenatally.


METHODS
Using fetal magnetocardiography (FMCG: the magnetic equivalent of the fetal ECG), we investigated standard HRV measures in a homogenous group of 20 healthy fetuses. Ten HRV measures were analyzed in 60 five-minute RR interval time series derived from FMCG acquisitions (16th-40th week of gestation).


RESULTS
Using regression analysis, we found a clear dependency on gestational age and mean RR interval for measures from the time and frequency domains as well as for a measure for complexity. Correlation analysis revealed a strong interdependency of the measures, in particular within the specific domains. An adequate description of fetal HRV may be achieved using the standard deviation from the time domain, the high frequency band (0.15-0.40 Hz) from the frequency domain and approximate entropy as a complexity measure.


CONCLUSIONS
The results indicate that different characteristics of fetal HRV are embedded in the different domains.
Van Leeuwen
Peter
P
Department of Biomagnetism, Grönemeyer Institute for Microtherapy, Bochum, Germany. petervl@microtherapy.de
Lange
Silke
S
Geue
Daniel
D
Grönemeyer
Dietrich
D
D000465:Algorithms; D015148:Cardiotocography / Q000379:methods*; D003936:Diagnosis, Computer-Assisted / Q000379:methods*; D005260:Female; D006321:Heart / Q000196:embryology / Q000502:physiology; D006339:Heart Rate / Q000502:physiology*; D006801:Humans; D053798:Magnetocardiography / Q000379:methods*; D010363:Pattern Recognition, Automated / Q000379:methods*; D011247:Pregnancy; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity