Th1 and Th2 cells help CD8 T-cell responses.
Help from CD4 T cells is often important for the establishment of primary and memory CD8 T-cell responses. However, it has yet to be determined whether T helper polarization affects the delivery of help and/or whether responding CD8 T cells helped by Th1 or Th2 cells express distinct effector properties. To address these issues, we compared CD8 T-cell responses in the context of Th1 or Th2 help by injecting dendritic cells copulsed with the major histocompatibility complex class I-restricted OVA peptide plus, respectively, bacterial or helminth antigens. We found that Th2 cells, like Th1 cells, can help primary and long-lived memory CD8 T-cell responses. Experiments in interleukin-12 (IL-12)-/- and IL-4-/- mice, in which polarized Th1 or Th2 responses, respectively, fail to develop, indicate that the underlying basis of CD4 help is independent of attributes acquired as a response to polarization.
Ekkens
Melinda J
MJ
Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, 380 South University Ave., Philadelphia, PA 19104-4593, USA.
Shedlock
Devon J
DJ
Jung
Euihye
E
Troy
Amy
A
Pearce
Erika L
EL
Shen
Hao
H
Pearce
Edward J
EJ
D000818:Animals; D000942:Antigens, Bacterial / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D003713:Dendritic Cells / Q000276:immunology; D005260:Female; D015801:Helminth Proteins / Q000276:immunology; D007156:Immunologic Memory / Q000276:immunology*; D018664:Interleukin-12 / Q000172:deficiency / Q000235:genetics; D015847:Interleukin-4 / Q000172:deficiency / Q000235:genetics; D008213:Lymphocyte Activation / Q000276:immunology*; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D010047:Ovalbumin / Q000737:chemistry / Q000494:pharmacology; D018417:Th1 Cells / Q000276:immunology*; D018418:Th2 Cells / Q000276:immunology*
D000942:Antigens, Bacterial; D015801:Helminth Proteins; D018664:Interleukin-12; D015847:Interleukin-4; D010047:Ovalbumin