Antimalarial activity of 1-aryl-3,3-dialkyltriazenes.
The antimalarial activity of 1-aryl-3,3-dialkyltriazenes to Plasmodium berghei NK-65 in infected mice was evaluated at an intraperitoneal dose of 100mg/kgbw. Some of these compounds were found to possess potent antimalarial activity.
Nishiwaki
Keiji
K
Department of Pharmaceutical Sciences, School of Pharmacy, Kinki University, 3-4-1 Kowakae, Higashiosaka, Osaka 577-8502, Japan. k-nishi@phar.kindai.ac.jp
Okamoto
Azusa
A
Matsuo
Keizo
K
Kawaguchi
Yosuke
Y
Hayase
Yoshio
Y
Ohba
Katsuaki
K
D000818:Animals; D000962:Antimalarials / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000494:pharmacology*; D004912:Erythrocytes / Q000469:parasitology; D005260:Female; D007202:Indicators and Reagents; D007274:Injections, Intraperitoneal; D007279:Injections, Subcutaneous; D009682:Magnetic Resonance Spectroscopy; D008288:Malaria / Q000188:drug therapy* / Q000469:parasitology*; D051379:Mice; D008813:Mice, Inbred ICR; D010962:Plasmodium berghei / Q000187:drug effects*; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared; D016019:Survival Analysis; D014227:Triazines / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000494:pharmacology*
D000962:Antimalarials; D007202:Indicators and Reagents; D014227:Triazines