Functional modeling of neural-glial interaction.
We propose a generalized mathematical model for a small neural-glial ensemble. The model incorporates subunits of the tripartite synapse that includes a presynaptic neuron, the synaptic terminal itself, a postsynaptic neuron, and a glial cell. The glial cell is assumed to be activated via two different pathways: (i) the fast increase of intercellular [K(+)] produced by the spiking activity of the postsynaptic neuron, and (ii) the slow production of a mediator triggered by the synaptic activity. Our model predicts the long-term potentiation of the postsynaptic neuron as well as various [Ca(2+)] transients in response to the activation of different pathways.
Postnov
D E
DE
Physics Department, Saratov State University, Astrakhanskaya Street 83, Saratov 410026, Russia. postnov@chaos.ssu.runnet.ru
Ryazanova
L S
LS
Sosnovtseva
O V
OV
D017774:Long-Term Potentiation; D008959:Models, Neurological; D009457:Neuroglia / Q000737:chemistry* / Q000378:metabolism; D009474:Neurons / Q000166:cytology* / Q000378:metabolism; D011188:Potassium / Q000378:metabolism
D011188:Potassium