The association between residential pesticide use and cutaneous melanoma.
Occupational pesticide exposure has been linked to cutaneous melanoma in epidemiological studies. We studied the association between cutaneous melanoma and the residential use of pesticides. This is a case-control study of cutaneous melanoma (287 incident cases; 299 controls). Data on pesticide use was obtained with a standardised interview. An increased risk of melanoma was found for high use (4 times annually) of indoor pesticides (odds ratio (OR)=2.18; 95% confidence intervals (CI) 1.07-4.43) compared to low use (1 times annually), after adjustment for sex, age, education, sun exposure and pigmentary characteristics. Subjects exposed for 10 years or more had two and a half times the risk (OR=2.46; 95% CI 1.23-4.94) of those exposed for less than 10 years. A dose response was observed for the intensity of pesticides use (p(trend)=0.027). The results indicate that residential pesticide exposure may be an independent risk factor for cutaneous melanoma.
Fortes
Cristina
C
Clinical Epidemiology Unit, Istituto Dermopatico dell'Immacolata (IDI-IRCCS), Via dei Monti di Creta, 104, 00167 Rome, Italy. c.fortes@idi.it
Mastroeni
Simona
S
Melchi
Franco
F
Pilla
Maria Antonietta
MA
Alotto
Massimo
M
Antonelli
Gianluca
G
Camaione
Diana
D
Bolli
Simone
S
Luchetti
Elisabetta
E
Pasquini
Paolo
P
D000293:Adolescent; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D004781:Environmental Exposure / Q000009:adverse effects*; D005260:Female; D006801:Humans; D015994:Incidence; D007558:Italy / Q000453:epidemiology; D008297:Male; D008545:Melanoma / Q000139:chemically induced* / Q000453:epidemiology; D008875:Middle Aged; D010575:Pesticides / Q000633:toxicity*; D012878:Skin Neoplasms / Q000139:chemically induced* / Q000453:epidemiology; D013471:Sunburn / Q000453:epidemiology; D013472:Sunlight / Q000009:adverse effects
D010575:Pesticides