Use of the collagen gel droplet embedded drug sensitivity test to determine drug sensitivity against ovarian mature cystic teratoma with malignant transformation to adenocarcinoma: a case report.
BACKGROUND
The collagen gel droplet embedded drug sensitivity test (CD-DST) is a new anticancer drug sensitivity test that only requires a small number of cells. We report the use of this test in the choice of adjuvant chemotherapy for treatment of a rare case of ovarian cancer involving malignant transformation of ovarian mature cystic teratoma.


METHODS
The patient was a 70-year-old female with an ovarian tumor, pleural effusion, carcinomatous ascites and a chest wall tumor. The histopathological diagnosis was adenocarcinoma, mature cystic teratoma with malignant transformation, stage IV. Paclitaxel/carboplatin therapy was selected as adjuvant chemotherapy based on CD-DST results. Upon completion of 6 courses, no increases in carcinomatous ascites or recurrent lesions were evident, and the chest wall tumor had disappeared completely.


CONCLUSIONS
The CD-DST may be particularly useful for selecting preoperative chemotherapeutic drugs for patients with ovarian cancer in which the histological type of the primary tumor is unknown.
Yamagami
Wataru
W
Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan. y_gami@msc.biglobe.ne.jp
Banno
Kouji
K
Kawaguchi
Makiko
M
Yanokura
Megumi
M
Kuwabara
Yoshiko
Y
Hirao
Nobumaru
N
Susumu
Nobuyuki
N
Tsukazaki
Katsumi
K
Aoki
Daisuke
D
D000230:Adenocarcinoma / Q000188:drug therapy* / Q000473:pathology; D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols; D016190:Carboplatin / Q000008:administration & dosage; D024042:Collagen Type I; D004354:Drug Screening Assays, Antitumor; D005260:Female; D005782:Gels; D006801:Humans; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000473:pathology; D017239:Paclitaxel / Q000008:administration & dosage; D016066:Pleural Effusion, Malignant; D013724:Teratoma / Q000188:drug therapy* / Q000473:pathology
D000970:Antineoplastic Agents; D024042:Collagen Type I; D005782:Gels; D016190:Carboplatin; D017239:Paclitaxel