title: Bioactive saponins and glycosides. XXVII. Structures of new cucurbitane-type triterpene glycosides and antiallergic constituents from Citrullus colocynthis.
abstract: The methanolic extract from the fruit of Citrullus colocynthis showed an inhibitory effect on ear passive cutaneous anaphylaxis reactions as a type I allergic model in mice. From the methanolic extract, two new cucurbitane-type triterpene glycosides, colocynthosides A and B, were isolated together with 17 known constituents. The structures of colocynthosides A and B were elucidated on the basis of chemical and physicochemical evidence. In addition, the principal cucurbitane-type triterpene glycoside, cucurbitacin E 2-O-beta-D-glucopyranoside, and its aglycon, cucurbitacin E, exhibited the antiallergic activity at a dose of 100 and 1.25 mg/kg, p.o., respectively.
authors.affiliation: Kyoto Pharmaceutical University, Yamashina-ku, Kyoto, Japan. myoshika@mb.kyoto-phu.ac.jp
authors.forename: Masayuki
authors.initials: M
authors.lastname: Yoshikawa
authors.forename: Toshio
authors.initials: T
authors.lastname: Morikawa
authors.forename: Hisanori
authors.initials: H
authors.lastname: Kobayashi
authors.forename: Akihiko
authors.initials: A
authors.lastname: Nakamura
authors.forename: Koudai
authors.initials: K
authors.lastname: Matsuhira
authors.forename: Seikou
authors.initials: S
authors.lastname: Nakamura
authors.forename: Hisashi
authors.initials: H
authors.lastname: Matsuda
mesh_terms: D000707:Anaphylaxis / Q000188:drug therapy; D000818:Animals; D029773:Citrullus / Q000737:chemistry*; D006027:Glycosides / Q000737:chemistry* / Q000494:pharmacology*; D008297:Male; D051379:Mice; D015394:Molecular Structure; D012503:Saponins / Q000737:chemistry* / Q000494:pharmacology*; D014315:Triterpenes / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D006027:Glycosides; D012503:Saponins; D014315:Triterpenes; C514277:cucurbitane