title: Enantioselective hydrogenation of quinolines catalyzed by Ir(BINAP)-cored dendrimers: dramatic enhancement of catalytic activity.
abstract: [structure: see text]. The asymmetric hydrogenation of quinolines catalyzed by chiral dendritic catalysts derived from BINAP gave the corresponding products with high enantioselectivities (up to 93%), excellent catalytic activities (TOF up to 3450 h(-1)), and productivities (TON up to 43,000). In addition, the third-generation catalyst could be recovered by precipitation and filtration and reused at least six times with similar enantioselectivity.
authors.affiliation: Beijing National Laboratory for Molecular Sciences, Center for Chemical Biology, Institute of Chemistry, Chinese Academy of Sciences, Beijing, China.
authors.forename: Zhi-Jian
authors.initials: ZJ
authors.lastname: Wang
authors.forename: Guo-Jun
authors.initials: GJ
authors.lastname: Deng
authors.forename: Yong
authors.initials: Y
authors.lastname: Li
authors.forename: Yan-Mei
authors.initials: YM
authors.lastname: He
authors.forename: Wei-Jun
authors.initials: WJ
authors.lastname: Tang
authors.forename: Qing-Hua
authors.initials: QH
authors.lastname: Fan
mesh_terms: D002384:Catalysis; D050091:Dendrimers / Q000138:chemical synthesis / Q000737:chemistry; D006865:Hydrogenation; D007495:Iridium / Q000737:chemistry*; D015394:Molecular Structure; D009281:Naphthalenes / Q000138:chemical synthesis / Q000737:chemistry; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry; D011804:Quinolines / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: C406943:BINAP, 2-naphthol; D050091:Dendrimers; D009281:Naphthalenes; D009942:Organometallic Compounds; D011804:Quinolines; D007495:Iridium