title: Influences of histamine H1 receptor antagonists on maximal electroshock seizure in infant rats.
abstract: The influences of histamine H1 receptor antagonists on maximal electroshock seizure were studied using infant rats. In this study, electroconvulsion was induced by stimulating rats using ear-clip electrodes, and the durations of electroencephalogram (EEG) seizure, tonic extensor (TE) seizure and clonic (CL) seizure induced by maximal electroshock were measured. Diphenhydramine, chlorpheniramine, cyproheptadine and ketotifen caused a dose-dependent and significant prolongation of both EEG seizure and TE seizure induced by maximal electroshock. On the other hand, epinastine and fexofenadine caused no such effects, even at a dose of 50 mg/kg. All drugs used in this study showed no significant effect on CL seizure induced by maximal electroshock. From these findings, it is suggested that epinastine and fexofenadine may cause no harmful influence on epilepsy, even when used in a little child.
authors.affiliation: Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 1-1-1 Tsushima-naka, Okayama 700-8530, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Ishikawa
authors.forename: Kenshi
authors.initials: K
authors.lastname: Takechi
authors.forename: Ashequr
authors.initials: A
authors.lastname: Rahman
authors.forename: Jun
authors.initials: J
authors.lastname: Ago
authors.forename: Naotaka
authors.initials: N
authors.lastname: Matsumoto
authors.forename: Aya
authors.initials: A
authors.lastname: Murakami
authors.forename: Chiaki
authors.initials: C
authors.lastname: Kamei
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000833:Animals, Suckling; D002744:Chlorpheniramine / Q000008:administration & dosage / Q000494:pharmacology; D003533:Cyproheptadine / Q000008:administration & dosage / Q000494:pharmacology; D003984:Dibenzazepines / Q000008:administration & dosage / Q000494:pharmacology; D004155:Diphenhydramine / Q000008:administration & dosage / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004569:Electroencephalography / Q000187:drug effects*; D004597:Electroshock / Q000009:adverse effects; D006634:Histamine H1 Antagonists / Q000008:administration & dosage / Q000494:pharmacology*; D007093:Imidazoles / Q000008:administration & dosage / Q000494:pharmacology; D007665:Ketotifen / Q000008:administration & dosage / Q000494:pharmacology; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012640:Seizures / Q000209:etiology / Q000503:physiopathology*; D016593:Terfenadine / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000494:pharmacology; D013997:Time Factors
chemical_list: D003984:Dibenzazepines; D006634:Histamine H1 Antagonists; D007093:Imidazoles; D003533:Cyproheptadine; D002744:Chlorpheniramine; D016593:Terfenadine; D004155:Diphenhydramine; C093230:fexofenadine; C053090:epinastine; D007665:Ketotifen