title: Gamma interferon suppresses erythropoiesis via interleukin-15.
abstract: Impaired erythropoiesis causes anemia during genetic disorders, chronic disease, and infection. In studies of the underlying mechanisms researchers have increasingly focused on gamma interferon (IFN-gamma). Here, we identified a previously unrecognized role for interleukin-15 (IL-15) in red blood cell homeostasis and demonstrated that IFN-gamma and signal transducer and activator of transcription protein 1-dependent pathways up-regulate expression of IL-15 in vivo. These findings identified new therapeutic targets for anemia.
authors.affiliation: Trudeau Institute, Saranac Lake, New York, USA. mullarky@vt.edu
authors.forename: Isis K
authors.initials: IK
authors.lastname: Mullarky
authors.forename: Frank M
authors.initials: FM
authors.lastname: Szaba
authors.forename: Lawrence W
authors.initials: LW
authors.lastname: Kummer
authors.forename: Lindsey B
authors.initials: LB
authors.lastname: Wilhelm
authors.forename: Michelle A
authors.initials: MA
authors.lastname: Parent
authors.forename: Lawrence L
authors.initials: LL
authors.lastname: Johnson
authors.forename: Stephen T
authors.initials: ST
authors.lastname: Smiley
mesh_terms: D000740:Anemia / Q000469:parasitology / Q000503:physiopathology; D000818:Animals; D001854:Bone Marrow Cells; D002478:Cells, Cultured; D004920:Erythropoiesis / Q000187:drug effects*; D007371:Interferon-gamma / Q000494:pharmacology*; D019409:Interleukin-15 / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL; D050794:STAT1 Transcription Factor / Q000378:metabolism; D014122:Toxoplasma / Q000472:pathogenicity*; D014124:Toxoplasmosis, Animal / Q000469:parasitology / Q000503:physiopathology*; D015854:Up-Regulation
chemical_list: D019409:Interleukin-15; D050794:STAT1 Transcription Factor; D007371:Interferon-gamma