title: Benefits and risks of mitomycin use in the traumatized tracheal mucosa.
abstract: OBJECTIVE
  To investigate the efficacy and early complications of mitomycin C (MMC) in tracheal wound models.
  
  
  METHODS
  Rabbits (N = 60) were randomized to undergo mucosal injuries to the upper and lower trachea including anterior 120 degrees full thickness (group A, n = 20), anterior 120 degrees partial thickness (group B, 20), and circumferential partial thickness (group C, 20). In each rabbit, the wounds were separately treated with MMC 1.0 mg/mL or saline, and the animals were sacrificed after three weeks.
  
  
  RESULTS
  Twenty-seven of the 60 animals experienced early death because of tracheal rupture or airway obstruction caused by unresolved scabs on the preinjured tracheal mucosa; the incidence of early death was higher in groups A and C than in group B. In each group, the degree of tracheal stenosis was comparable in wounds treated with MMC and saline.
  
  
  CONCLUSIONS
  These findings suggest that topical MMC has no benefit when used to prevent tracheal stenosis. Acute airway obstruction may occur in MMC-treated rabbits with tracheal wounds.
authors.affiliation: Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
authors.forename: Jong-Lyel
authors.initials: JL
authors.lastname: Roh
authors.forename: Dong Hyun
authors.initials: DH
authors.lastname: Kim
authors.forename: Ki Sang
authors.initials: KS
authors.lastname: Rha
authors.forename: Myung-Whun
authors.initials: MW
authors.lastname: Sung
authors.forename: Kwang Hyun
authors.initials: KH
authors.lastname: Kim
authors.forename: Chan Il
authors.initials: CI
authors.lastname: Park
mesh_terms: D000402:Airway Obstruction / Q000209:etiology; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000009:adverse effects / Q000627:therapeutic use*; D002423:Cause of Death; D002921:Cicatrix / Q000209:etiology; D004195:Disease Models, Animal; D005260:Female; D016685:Mitomycin / Q000009:adverse effects / Q000627:therapeutic use*; D009336:Necrosis; D011817:Rabbits; D011897:Random Allocation; D020545:Respiratory Mucosa / Q000293:injuries* / Q000601:surgery; D018570:Risk Assessment; D012422:Rupture, Spontaneous; D013536:Suture Techniques; D014132:Trachea / Q000293:injuries* / Q000601:surgery; D014135:Tracheal Stenosis / Q000209:etiology
chemical_list: D000903:Antibiotics, Antineoplastic; D016685:Mitomycin