The SXT/R391 family of integrative conjugative elements is composed of two exclusion groups.
Conjugative elements often encode entry exclusion systems that convert host cells into poor recipients for identical or similar elements. The diversity of exclusion systems within families of conjugative elements has received little attention. We report here the most comprehensive study to date of the diversity of exclusion determinants within a single family of conjugative elements. Unexpectedly, our analyses indicate that there are only two exclusion groups among the diverse members of the SXT/R391 family of integrative conjugative elements.
Marrero
Joeli
J
Channing Lab, Harvard Medical School, 181 Longwood Ave, Boston MA, 02115, USA.
Waldor
Matthew K
MK
D000595:Amino Acid Sequence; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001426:Bacterial Proteins / Q000235:genetics*; D003227:Conjugation, Genetic; D024881:Drug Resistance, Bacterial; D022761:Gene Transfer, Horizontal; D005798:Genes, Bacterial / Q000235:genetics; D014644:Genetic Variation; D006090:Gram-Negative Bacteria / Q000187:drug effects / Q000235:genetics*; D008969:Molecular Sequence Data; D016415:Sequence Alignment
D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins