Development of a library of 6-arylcoumarins as candidate fluorescent sensors.
[structure: see text]. A bromocoumarin scaffold (1) was reacted with various boronic acid derivatives (2a-l) to afford a library of 6-arylcoumarins (3a-l). This library was found to contain candidate fluorescent sensors for peptidase activity and for nitric oxide.
Hirano
Tomoya
T
School of Biomedical Science, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2-3-10 Kanda-Surugadai, Tokyo, Japan. hiraomc@tmd.ac.jp
Hiromoto
Kenichi
K
Kagechika
Hiroyuki
H
D015374:Biosensing Techniques; D001897:Boronic Acids / Q000737:chemistry*; D003374:Coumarins / Q000138:chemical synthesis* / Q000737:chemistry; D005456:Fluorescent Dyes / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure
D001897:Boronic Acids; D003374:Coumarins; D005456:Fluorescent Dyes