title: Hyperpolarized 13C MRI of the pulmonary vasculature and parenchyma.
abstract: The study of lung perfusion in normal and diseased subjects is of great interest to physiologists and physicians. In this work we demonstrate the application of a liquid-phase hyperpolarized (HP) carbon-13 ((13)C) tracer to magnetic resonance imaging (MRI) of the pulmonary vasculature and pulmonary perfusion in a porcine model. Our results show that high spatial and temporal resolution images of pulmonary perfusion can be obtained with this contrast technique. Traditionally, pulmonary perfusion measurement techniques have been challenging because of insufficient signal for quantitative functional assessments. The use of polarized (13)C in MRI overcomes this limitation and may lead to a viable clinical method for studying the pulmonary vasculature and perfusion.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University, Baltimore, Maryland 21224, USA. mishii3@jhmi.edu
authors.forename: Masaru
authors.initials: M
authors.lastname: Ishii
authors.forename: Kiarash
authors.initials: K
authors.lastname: Emami
authors.forename: Stephen
authors.initials: S
authors.lastname: Kadlecek
authors.forename: J Stefan
authors.initials: JS
authors.lastname: Petersson
authors.forename: Klaes
authors.initials: K
authors.lastname: Golman
authors.forename: Vahid
authors.initials: V
authors.lastname: Vahdat
authors.forename: Jiangsheng
authors.initials: J
authors.lastname: Yu
authors.forename: Robert V
authors.initials: RV
authors.lastname: Cadman
authors.forename: John
authors.initials: J
authors.lastname: MacDuffie-Woodburn
authors.forename: Michael
authors.initials: M
authors.lastname: Stephen
authors.forename: David A
authors.initials: DA
authors.lastname: Lipson
authors.forename: Rahim R
authors.initials: RR
authors.lastname: Rizi
mesh_terms: D000818:Animals; D002247:Carbon Isotopes; D003287:Contrast Media; D007089:Image Enhancement; D007091:Image Processing, Computer-Assisted; D008168:Lung / Q000098:blood supply*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D023421:Models, Animal; D013552:Swine
chemical_list: D002247:Carbon Isotopes; D003287:Contrast Media