Methyl 2-(2-(4-formylphenoxy)acetamido)-2-substituted acetate derivatives: a new class of acetylcholinesterase inhibitors.
A new class of inhibitors of acetylcholinesterase (methyl 2-(2-(4-formylphenoxy)acetamido)-2-substituted acetate derivatives) is described. Compounds 4b and 4i were found to be more potent than galanthamine in inhibiting acetylcholinesterase.
Wen
Huan
H
School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China.
Zhou
Yayao
Y
Lin
Chonglan
C
Ge
Hui
H
Ma
Lin
L
Wang
Zihou
Z
Peng
Wenlie
W
Song
Huacan
H
D000085:Acetates / Q000138:chemical synthesis* / Q000494:pharmacology; D000544:Alzheimer Disease / Q000188:drug therapy; D001547:Benzaldehydes / Q000138:chemical synthesis* / Q000494:pharmacology; D002800:Cholinesterase Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D020128:Inhibitory Concentration 50; D013329:Structure-Activity Relationship
D000085:Acetates; D001547:Benzaldehydes; D002800:Cholinesterase Inhibitors; C011483:4-hydroxybenzaldehyde