title: Circulating levels of adhesion molecules and markers of endothelial activation in acute inflammation induced by prolonged brisk exercise.
abstract: OBJECTIVE
  To investigate circulating levels of adhesion molecules and markers of endothelial activation in acute inflammation induced by prolonged brisk exercise.
  
  
  METHODS
  The circulating levels of adhesion molecules E-, L- and P-selectins, intercellular and vascular adhesion molecule-1 (ICAM-1 and VCAM-1), along with those of thrombomodulin (TM), N-terminal pro-brain natriuretic peptide (NT-pro-BNP) and cardiac troponin T, were measured before, at the end of and at 48 h post-race, in athletes participating in this extreme physical stress paradigm.
  
  
  RESULTS
  Levels of L- and P-selectins remained the same before and at the end of the "Spartathlon" race, presenting a similar decline at 48 h post-race. E-Selectin, ICAM-1 and TM reached a maximum value at the end of the race and returned to normal 48 h after the race. A similar profile was observed for VCAM-1 and NT-pro-BNP, with a tendency for a decrease at 48 h post-race, while troponin T was not detected.
  
  
  CONCLUSIONS
  The indices of endothelial activation are strongly affected during "Spartathlon" race, suggesting that, although prolonged brisk exercise activates the endothelium, it rapidly recovers.
authors.affiliation: Department of Clinical Biochemistry, Aghia Sophia Children's Hospital, GR 11527, Athens, Greece.
authors.forename: Anastasia I
authors.initials: AI
authors.lastname: Bartzeliotou
authors.forename: Alexandra P
authors.initials: AP
authors.lastname: Margeli
authors.forename: Maria
authors.initials: M
authors.lastname: Tsironi
authors.forename: Katerina
authors.initials: K
authors.lastname: Skenderi
authors.forename: Chryssa
authors.initials: C
authors.lastname: Bacoula
authors.forename: George P
authors.initials: GP
authors.lastname: Chrousos
authors.forename: Ioannis
authors.initials: I
authors.lastname: Papassotiriou
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D015815:Cell Adhesion Molecules / Q000097:blood*; D015444:Exercise / Q000502:physiology*; D006801:Humans; D007249:Inflammation / Q000097:blood* / Q000209:etiology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D013997:Time Factors
chemical_list: D015415:Biomarkers; D015815:Cell Adhesion Molecules