Progenitor cells for cardiac repair.
Repair of diseased or injured myocardium by cell-based therapies is likely to require a multi-pronged approach. New myocytes will need to be generated, integrated with existing myocardial tissue, and perfused with a newly acquired vascular system. There are many potential avenues to achieve this goal, and optimizing repair is likely to require a synthetic therapeutic approach. In this review, we discuss several issues to be considered in cell-based cardiac repair, some progress which has been made toward this goal, and future directions.
Evans
Sylvia M
SM
Skaggs School of Pharmacy and Pharmaceutical Sciences and Department of Medicine, University of California, San Diego, CA 92014, USA. syevans@ucsd.edu
Mummery
Christine
C
Doevendans
Pieter A
PA
D000818:Animals; D001854:Bone Marrow Cells / Q000502:physiology; D006321:Heart / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D009206:Myocardium / Q000166:cytology; D032383:Myocytes, Cardiac / Q000502:physiology; D018919:Neovascularization, Physiologic; D012038:Regeneration; D033581:Stem Cell Transplantation; D013234:Stem Cells / Q000502:physiology*; D014182:Transplantation, Autologous / Q000502:physiology; D014184:Transplantation, Homologous / Q000502:physiology