title: Intrathecal anesthesia for elderly patients undergoing short transurethral procedures: a dose-finding study.
abstract: One hundred elderly men (> or =65 yr) undergoing transurethral procedures (<45 min) received bupivacaine 7.5 mg, or bupivacaine 5 mg + fentanyl 20 mug, or bupivacaine 4 mg + fentanyl 20 mug, or bupivacaine 3 mg + fentanyl 20 mug, intrathecally. Intraoperative "rescue" fentanyl requirements were higher (P < 0.03) in group bupivacaine 3 mg + fentanyl. Times (min) to ambulation eligibility were decreased in a dose-dependant manner (157 +/- 50 vs 147 +/- 37 vs 128 +/- 40 vs 116 +/- 29, respectively). Of the techniques studied, intrathecal bupivacaine 4 mg + fentanyl 20 mug provided adequate analgesia and was associated with hemodynamic stability and a favorable recovery profile.
authors.affiliation: Department of Anesthesiology, Intensive Care and Pain Management, Meir Medical Center, Kfar Saba, Israel.
authors.forename: Edna
authors.initials: E
authors.lastname: Zohar
authors.forename: Yossi
authors.initials: Y
authors.lastname: Noga
authors.forename: Uri
authors.initials: U
authors.lastname: Rislick
authors.forename: Ilan
authors.initials: I
authors.lastname: Leibovitch
authors.forename: Brian
authors.initials: B
authors.lastname: Fredman
mesh_terms: D000368:Aged; D000758:Anesthesia / Q000379:methods*; D018686:Anesthetics, Intravenous / Q000008:administration & dosage*; D000779:Anesthetics, Local / Q000008:administration & dosage*; D001794:Blood Pressure; D002045:Bupivacaine / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D005260:Female; D005283:Fentanyl / Q000008:administration & dosage*; D006801:Humans; D007278:Injections, Spinal / Q000379:methods*; D008297:Male; D011446:Prospective Studies; D013997:Time Factors; D014521:Urethra / Q000601:surgery*
chemical_list: D018686:Anesthetics, Intravenous; D000779:Anesthetics, Local; D005283:Fentanyl; D002045:Bupivacaine