An enantioselective chiral Brønsted acid catalyzed imino-azaenamine reaction.
The enantioselective Brønsted acid catalyzed addition of methyleneaminopyrrolidine to N-Boc imines has been achieved in the presence of chiral phosphoric acids derived from 3,3'-di(phenanthryl)-H8-BINOL. The corresponding aminohydrazones have been isolated in good yields with enantiomeric excesses up to 90%. [reaction: see text]
Rueping
Magnus
M
Degussa Endowed Professorship, Institute of Chemistry and Chemical Biology, Johann-Wolfgang Goethe University Frankfurt am Main, Max-von-Laue Strasse 7, D-60438 Frankfurt, Germany. m.rueping@chemie.uni-frankfurt.de
Sugiono
Erli
E
Theissmann
Thomas
T
Kuenkel
Alexander
A
Köckritz
Angela
A
Pews-Davtyan
Anahit
A
Nemati
Navid
N
Beller
Matthias
M