The adaptive immunologic microenvironment in colorectal cancer: a novel perspective.
Colorectal cancer is one of the most common malignancies, often presenting with a poor prognosis. To date, the anatomic extent of disease has been by far the most important prognostic factor. Recently, we obtained evidence that the type, density, and location of immune cells in colorectal cancer could provide a prognostic factor superior and independent to that of criteria related to the anatomic extent of the tumor. Here, we discuss the meaning and potential implications of this novel finding.
Galon
Jérôme
J
Institut National de la Sante et de la Recherche Medicale, UMRS872, Team 13 and Avenir team, Cordeliers Research Center, F-75006 Paris, France. jerome.galon@u255.bhdc.jussieu.fr
Fridman
Wolf-Herman
WH
Pagès
Franck
F
D000818:Animals; D015415:Biomarkers / Q000032:analysis; D015179:Colorectal Neoplasms / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular; D008954:Models, Biological; D011379:Prognosis
D015415:Biomarkers