title: Preoperative external beam radiotherapy and reduced dose brachytherapy for carcinoma of the cervix: survival and pathological response.
abstract: OBJECTIVE
  To evaluate the pathologic response of cervical carcinoma to external beam radiotherapy (EBRT) and high dose rate brachytherapy (HDRB) and outcome.
  
  
  METHODS
  Between 1992 and 2001, 67 patients with cervical carcinoma were submitted to preoperative radiotherapy. Sixty-five patients were stage IIb. Preoperative treatment included 45 Gy EBRT and 12 Gy HDRB. Patients were submitted to surgery after a mean time of 82 days. Lymphadenectomy was performed in 81% of patients. Eleven patients with residual cervix residual disease on pathological specimen were submitted to 2 additional insertions of HDRB.
  
  
  RESULTS
  median follow up was 72 months. Five-year cause specific survival was 75%, overall survival 65%, local control 95%. Complete pelvic pathological response was seen in 40%. Surgery performed later than 80 days was associated with pathological response. Pelvic nodal involvement was found in 12%. Complete pelvic pathological response and negative lymphnodes were associated with better outcome (p = .03 and p = .005). Late grade 3 and 4 urinary and intestinal adverse effects were seen in 12 and 2% of patients.
  
  
  CONCLUSIONS
  Time allowed between RT and surgery correlated with pathological response. Pelvic pathological response was associated with improved outcome. Postoperative additional HDRB did not improve therapeutic results. Treatment was well tolerated.
authors.affiliation: Department of Radiation Oncology, Hospital do Cancer A C Camargo, São Paulo, Brazil. aajacinto@yahoo.com.br
authors.forename: Alexandre A
authors.initials: AA
authors.lastname: Jacinto
authors.forename: Marcus S
authors.initials: MS
authors.lastname: Castilho
authors.forename: Paulo E R S
authors.initials: PE
authors.lastname: Novaes
authors.forename: Pablo R
authors.initials: PR
authors.lastname: Novick
authors.forename: Gustavo A
authors.initials: GA
authors.lastname: Viani
authors.forename: João V
authors.initials: JV
authors.lastname: Salvajoli
authors.forename: Robson
authors.initials: R
authors.lastname: Ferrigno
authors.forename: Antonio Cássio A
authors.initials: AC
authors.lastname: Pellizzon
authors.forename: Stella S S
authors.initials: SS
authors.lastname: Lima
authors.forename: Maria A C
authors.initials: MA
authors.lastname: Maia
authors.forename: Ricardo C
authors.initials: RC
authors.lastname: Fogaroli
mesh_terms: D000328:Adult; D000368:Aged; D001918:Brachytherapy / Q000379:methods*; D005260:Female; D006801:Humans; D008197:Lymph Node Excision / Q000379:methods; D008207:Lymphatic Metastasis; D008875:Middle Aged; D011878:Radiotherapy / Q000379:methods*; D011879:Radiotherapy Dosage; D013997:Time Factors; D016896:Treatment Outcome; D002583:Uterine Cervical Neoplasms / Q000532:radiotherapy*