Formin the way.
Reorganization of the actin cytoskeleton requires nucleating factors, which initiate actin fiber formation. In this issue of Immunity, the functions of two classes of actin nucleators are examined in T lymphocytes, giving insight into the regulation of T cell polarity (Gomez et al., 2007).
Schwartzberg
Pamela L
PL
National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA. pams@mail.nih.gov
D051376:Actin-Related Protein 2-3 Complex / Q000276:immunology / Q000378:metabolism; D000199:Actins / Q000378:metabolism*; D048868:Adaptor Proteins, Signal Transducing / Q000276:immunology / Q000378:metabolism; D000818:Animals; D016764:Cell Polarity / Q000276:immunology*; D003598:Cytoskeletal Proteins / Q000276:immunology* / Q000378:metabolism; D003599:Cytoskeleton; D000080865:Formins; D006801:Humans; D008213:Lymphocyte Activation / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism
D051376:Actin-Related Protein 2-3 Complex; D000199:Actins; D048868:Adaptor Proteins, Signal Transducing; D003598:Cytoskeletal Proteins; C108962:DIAPH1 protein, human; C476204:FMNL1 protein, human; D000080865:Formins