title: Pharmacological management of acute mania: does current prescribing practice reflect treatment guidelines?
abstract: The records of 70 inpatients with an acute manic episode were audited, to examine the relationship between current prescribing practice, the recommendations of recent clinical guidance and short-term clinical outcomes. Overall, 38 combinations of medication were prescribed. Within the first 24 hours of treatment, monotherapy with a second generation antipsychotic was favoured. At discharge, combination treatment (a mood stabilizer and a second generation antipsychotic) predominated. Early initiation of medication was significantly associated with an earlier clinical decision to discharge. Prescribing was generally in accord with published guidelines. The findings reinforce the value of prescribing surveys in mental health and the need to share understanding of the constraints that may lead to deviation from prescribing guidelines.
authors.affiliation: Department of Psychological Medicine, Institute of Psychiatry, London, UK.
authors.forename: A
authors.initials: A
authors.lastname: Streeruwitz
authors.forename: T R E
authors.initials: TR
authors.lastname: Barnes
authors.forename: J
authors.initials: J
authors.lastname: Fehler
authors.forename: R
authors.initials: R
authors.lastname: Ohlsen
authors.forename: V A
authors.initials: VA
authors.lastname: Curtis
mesh_terms: D000328:Adult; D018692:Antimanic Agents / Q000627:therapeutic use*; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D001714:Bipolar Disorder / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D019317:Evidence-Based Medicine; D005260:Female; D019983:Guideline Adherence / Q000706:statistics & numerical data*; D006801:Humans; D008297:Male; D008485:Medical Audit; D008499:Medical Records; D008875:Middle Aged; D010351:Patient Discharge; D017410:Practice Guidelines as Topic; D010818:Practice Patterns, Physicians'
chemical_list: D018692:Antimanic Agents; D014150:Antipsychotic Agents