Oral manifestations of Wegener's granulomatosis: a report of three cases and a literature review.
BACKGROUND
Hyperplastic granular gingivitis or "strawberry gingivitis" is a rare manifestation of Wegener's granulomatosis (WG), but it is nearly pathognomonic for this multisystem autoimmune vasculitis. The dentist may be the first health care professional to see patients with symptoms and findings of this condition. Early diagnosis and treatment is the most important factor in the management of this potentially fatal disease.


METHODS
The authors present three case reports that demonstrate the disease spectrum and conducted a literature review focused on current understanding of this disease.


RESULTS
The first patient had only the classic gingival manifestations of the disease. The second patient had simultaneous typical gingival lesions, as well as dermatologic findings. The third patient had an atypical oral presentation of aphthous ulcers and erythematous gingiva, as well as respiratory and genital involvement. Reaching a definitive diagnosis sometimes is challenging owing to the subtle onset of the disease and variable clinical and laboratory findings.


CONCLUSIONS
Clinicians should be familiar with the broad variety of oral and systemic components of WG, as well as strategies to facilitate prompt disease recognition and to provide continued oral health care to these medically complex patients.
Stewart
Carol
C
Department of Oral and Maxillofacial Surgery and Diagnostic Sciences, University of Florida, College of Dentistry, Gainesville, FL 32610, USA. cstewart@dental.ufl.edu
Cohen
Donald
D
Bhattacharyya
Indraneel
I
Scheitler
Lawrence
L
Riley
Steven
S
Calamia
Kenneth
K
Migliorati
Cesar
C
Baughman
Ronald
R
Langford
Perry
P
Katz
Joseph
J
D000328:Adult; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000032:analysis; D003937:Diagnosis, Differential; D005260:Female; D005885:Gingival Hyperplasia / Q000188:drug therapy / Q000209:etiology*; D014890:Granulomatosis with Polyangiitis / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D019226:Oral Ulcer / Q000188:drug therapy / Q000209:etiology*; D012852:Sinusitis / Q000209:etiology
D019268:Antibodies, Antineutrophil Cytoplasmic