title: Wear and biological activity of highly crosslinked polyethylene in the hip under low serum protein concentrations.
abstract: Crosslinked ultra-high molecular weight polyethylene (UHMWPE) has been developed and introduced into clinical practice in order to reduce wear in the hip. Zero wear of highly crosslinked UHMWPE in vitro has been reported by some groups using lubricants with high concentrations of serum proteins in hip simulators. In contrast, some clinical studies have reported finite wear rates. The aim of this study was to compare the wear rates, wear surfaces, and wear debris produced by UHMWPE with different levels of crosslinking in a hip joint simulator, with lower, more physiologically relevant concentrations of protein in the lubricant. The UHMWPEs were tested in the Leeds ProSim hip joint simulator against cobalt-chromium (CoCr) femoral heads. The wear particles were isolated and imaged using a field emission gun scanning electron microscope (FEGSEM) at high resolution. The highly crosslinked UHMWPEs had significantly lower wear volumes than the non-crosslinked UHMWPEs. No significant difference was found in the percentage number and percentage volume of the particles in different size ranges from any of the materials. They had similar values of specific biological activity. The functional biological activity (FBA), which takes into account the wear volume and specific biological activity, showed that the highly crosslinked UHMWPEs had lower FBAs due to their lower wear volume.
authors.affiliation: Institute of Medical and Biological Engineering, School of Mechanical Engineering, University of Leeds, Leeds, UK.
authors.forename: A L
authors.initials: AL
authors.lastname: Galvin
authors.forename: J L
authors.initials: JL
authors.lastname: Tipper
authors.forename: L M
authors.initials: LM
authors.lastname: Jennings
authors.forename: M H
authors.initials: MH
authors.lastname: Stone
authors.forename: Z M
authors.initials: ZM
authors.lastname: Jin
authors.forename: E
authors.initials: E
authors.lastname: Ingham
authors.forename: I
authors.initials: I
authors.lastname: Fisher
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry*; D001798:Blood Proteins / Q000737:chemistry*; D019544:Equipment Failure Analysis; D006621:Hip Joint / Q000737:chemistry* / Q000601:surgery; D006622:Hip Prosthesis; D008153:Lubrication; D008422:Materials Testing; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure*; D010316:Particle Size; D011095:Polyethylenes / Q000737:chemistry*
chemical_list: D001672:Biocompatible Materials; D001798:Blood Proteins; D011095:Polyethylenes; C111601:ultra-high molecular weight polyethylene