[Treatment and prognostic analysis of 92 cases with advanced mobile tongue squamous cell carcinoma].
OBJECTIVE
To compare the results of different treatment modalities for the advanced tongue squamous cell carcinoma and investigate the factors that influence its prognosis.


METHODS
Ninety-two patients with advanced tongue squamous cell carcinoma without distant metastasis, treated in our hospital from Jan. 1990 to Dec. 1999 were retrospectively reviewed. Survival rate was estimated by Kaplan-Meier method, and multivariate analysis was performed by the Cox Proportional hazard model.


RESULTS
The overall 3-year and 5-year survival rates were 52.40% and 37.23% respectively. There was a significant difference in the overall between the two groups survival rate (chemotherapy only and radiotherapy after induced chemotherapy) and the three groups (operation only, operation after induced chemotherapy, radiotherapy after operation) cTNM stage, operation for the primary lesion and local recurrence were the independent factors that influenced the prognosis.


CONCLUSIONS
Risk factors that independently influence the survival of patients with advanced tongue squamous cell carcinoma were the local recurrence, cTNM and receiving operation or not for the primary lesion. Operation only or comprehensive therapy including operation could give a better prognosis, but the results of chemotherapy only or radiotherapy after chemotherapy were poor.
Sun
Chuan-zheng
CZ
Departmemt of Head and Neck Surgery, The Third Affiliated Hospital of Kunming Medical College, Kunming 650118, China. scz007@126.com
Chen
Fu-jin
FJ
Zeng
Zong-yuan
ZY
Deng
Li-fei
LF
Yang
An-kui
AK
Chen
Yan-feng
YF
D000328:Adult; D000368:Aged; D003131:Combined Modality Therapy / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D018307:Neoplasms, Squamous Cell / Q000473:pathology / Q000628:therapy*; D011379:Prognosis; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D014062:Tongue Neoplasms / Q000473:pathology / Q000628:therapy*