title: Bithiazole metabolites from the myxobacterium Myxococcus fulvus.
abstract: Two new bithiazole metabolites (3, 4) along with the previously reported compounds (1, 2) were isolated from the culture broth of the gliding bacterium Myxococcus fulvus collected from a Korean soil. The structures of these compounds were determined to be analogous to myxothiazole A on the basis of combined spectroscopic analyses. The new compounds exhibited significant cytotoxicity and moderate antifungal activity against the mouse fibloblast cell-line L929 and Candida albicans, respectively. These data were consistent with the previous finding that the bioactivity of myxothiazoles was highly dependent on the presence of terminal methoxy enol functionality.
authors.affiliation: Division of Marine Environment & Bioscience, College of Ocean Science and Technology, Korea Maritime University, Youngdo, Busan, Korea.
authors.forename: Jong-Woong
authors.initials: JW
authors.lastname: Ahn
authors.forename: Kyoung Hwa
authors.initials: KH
authors.lastname: Jang
authors.forename: Hyeong-Cheol
authors.initials: HC
authors.lastname: Yang
authors.forename: Ki-Bong
authors.initials: KB
authors.lastname: Oh
authors.forename: Hyi-Seung
authors.initials: HS
authors.lastname: Lee
authors.forename: Jongheon
authors.initials: J
authors.lastname: Shin
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000737:chemistry / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects; D002460:Cell Line; D005347:Fibroblasts / Q000187:drug effects; D051379:Mice; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D016940:Myxococcus / Q000378:metabolism*; D013844:Thiazoles / Q000737:chemistry* / Q000378:metabolism*
chemical_list: D000935:Antifungal Agents; D013844:Thiazoles