Noncoding RNAs and intranuclear positioning in monoallelic gene expression.
Mammalian X inactivation, imprinting, and allelic exclusion are classic examples of monoallelic gene expression. Two emerging themes are thought to be critical for monoallelic expression: (1) noncoding, often antisense, transcription linked to differential chromatin marks on otherwise homologous alleles and (2) physical segregation of alleles to separate domains within the nucleus. Here, we highlight recent progress in identifying these phenomena as possible key regulatory mechanisms of monoallelic expression.
Yang
Pok Kwan
PK
Howard Hughes Medical Institute, Boston, Massachusetts 02115, USA.
Kuroda
Mitzi I
MI
D000818:Animals; D002467:Cell Nucleus / Q000235:genetics* / Q000378:metabolism; D042002:Chromatin Assembly and Disassembly / Q000235:genetics; D016373:DNA, Antisense / Q000235:genetics; D005786:Gene Expression Regulation / Q000235:genetics*; D020868:Gene Silencing / Q000502:physiology*; D018392:Genomic Imprinting / Q000235:genetics; D006801:Humans; D019656:Loss of Heterozygosity / Q000235:genetics*; D022661:RNA, Untranslated / Q000235:genetics*; D014158:Transcription, Genetic / Q000235:genetics; D049951:X Chromosome Inactivation / Q000235:genetics*
D016373:DNA, Antisense; D022661:RNA, Untranslated