Isolated extramedullary relapse in the breast of a patient with acute myeloid leukemia following allogeneic stem cell transplantation: case report and review of the literature.
We report an unsual case of a woman with acute myeloid leukemia who showed an isolated extramedullary relapse (IEMR) in the breast following allogeneic stem cell transplantation and review the related literature. Eighty cases of IEMR following allogeneic stem cell transplantation, including our case, were identified. The review suggests that an M2 or M4 phenotype in the French-American-British classification and a favorable cytogenetic risk group are more frequently associated with the occurrence of IEMR. Combined treatment with radiation and high-dose chemotherapy may be effective.
Abdelkefi
Abderrahman
A
Centre National de Greffe de Moelle Osseuse, Tunis, Tunisia. aabdelkefi@yahoo.fr
Torjman
Lamia
L
Ladeb
Saloua
S
Sghaïer
Zeineb
Z
Jeddi
Ramzi
R
Lakhal
Amel
A
Ramzu
Amr
A
Gamoudi
Amor
A
Othman
Tarek Ben
TB
D000328:Adult; D001943:Breast Neoplasms / Q000188:drug therapy; D003131:Combined Modality Therapy; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy; D008297:Male; D012008:Recurrence; D033581:Stem Cell Transplantation; D014184:Transplantation, Homologous