Are the endothelial mechanisms of ACE-Is already established?
The endothelial mechanism of ACE-Is action is multifaceted. On the one hand, by inhibiting ACE, ACE-Is diminish Ang II synthesis, one of the best known active peptides. On the other hand, they modify synthesis and release of PGI(2) and NO via increasing production of other biologically important peptides like bradykinin, Ang-(1-7) or Ang-(1-9). Thus, ACE-Is play a crucial role in the function of endothelium and are effective and important tool for therapy of range of cardiovascular system disorders. Moreover, they are sensitive pharmacological instrument to elucidate and expand our knowledge about the role of RAS in human patophysiology.
Buczko
Włodzimierz
W
Department of Pharmacodynamics, Medical University of Białystok, Mickiewicza 2C, PL 15-089 Białystok, Poland. pharmdyn@amb.edu.pl
Kramkowski
Karol
K
Mogielnicki
Andrzej
A
D000804:Angiotensin II / Q000096:biosynthesis; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology*; D000818:Animals; D001920:Bradykinin / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000188:drug therapy* / Q000378:metabolism; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000378:metabolism; D011464:Epoprostenol / Q000378:metabolism; D006801:Humans; D009569:Nitric Oxide / Q000378:metabolism
D000806:Angiotensin-Converting Enzyme Inhibitors; D000804:Angiotensin II; D009569:Nitric Oxide; D011464:Epoprostenol; D001920:Bradykinin