title: Herpes simplex infection in a juvenile orangutan (Pongo pygmaeus pygmaeus).
abstract: A juvenile orangutan (Pongo pygmaeus pygmaeus) died after 8 days of diarrhea and vomiting. Necropsy showed petechial hemorrhages in the skin, the myocardium, and the peritoneal membranes. The lungs were hyperemic and edematous, and the liver and spleen were enlarged. Histologic changes consisted of interstitial pneumonia, hepatitis, and splenic hyperplasia. Numerous eosinophilic intranuclear inclusion bodies were visible in pulmonary epithelial cells, hepatocytes, and splenic endothelial cells. Electron microscopic examination revealed herpesvirus in hepatocyte nuclei. Polymerase chain reaction of liver tissue demonstrated the presence of a herpes simplex virus-1.
authors.affiliation: Section of Diseases in Exotic Animals and Wildlife, Department of Veterinary Pathobiology, Utrecht University, Yalelaan 1, Utrecht 3584 CL, The Netherlands.
authors.forename: Maria J L
authors.initials: MJ
authors.lastname: Kik
authors.forename: Jan H
authors.initials: JH
authors.lastname: Bos
authors.forename: Jan
authors.initials: J
authors.lastname: Groen
authors.forename: Gerry M
authors.initials: GM
authors.lastname: Dorrestein
mesh_terms: D000818:Animals; D000836:Animals, Zoo; D018420:Ape Diseases / Q000175:diagnosis*; D017809:Fatal Outcome; D005260:Female; D006561:Herpes Simplex / Q000175:diagnosis / Q000662:veterinary*; D008099:Liver / Q000821:virology; D008168:Lung / Q000821:virology; D011148:Pongo pygmaeus; D018139:Simplexvirus / Q000302:isolation & purification*; D013154:Spleen / Q000821:virology