title: Solvolysis study of cycliciminomitomycins.
abstract: The solvolysis rates for the substituted C(7)-cyclohexylamino- or C(8)-cyclohexyliminomitomycins 8-19 were determined in buffered methanolic solutions (0.06 M bis-Tris.HCl, pH: 5.5) at 25 degrees C and then compared with mitomycin C (1) and porfiromycin. Kinetic studies showed that C(8)-cyclohexyliminomitomycins 8-13 underwent solvolysis 150-230 times faster than mitomycin C (1) to give C(1)-methoxymitosene products. The solvolysis rates were slightly faster than that reported for 6. The C(7)-(2'-hydroxy)cyclohexylaminomitomycins 16-19 exhibited comparable solvolysis rates with 1 and porfiromycin.
authors.affiliation: College of Pharmacy, Catholic University of Daegu, Gyeongsan, Gyeongbuk, Korea. yna7315@cu.ac.kr
authors.forename: Younghwa
authors.initials: Y
authors.lastname: Na
mesh_terms: D006868:Hydrolysis; D008937:Mitomycins / Q000737:chemistry*; D015394:Molecular Structure
chemical_list: D008937:Mitomycins