title: [Effects of Jujingwan on nitric oxide and superoxide dismutase in seminal plasma of asthenospermia patients].
abstract: OBJECTIVE
  To explore the possible action mechanism of Jujingwan on asthenospermia.
  
  
  METHODS
  Semen routine analyses and determination of nitric oxide (NO) concentration and superoxide dismutase (SOD) activity in seminal plasma were performed in 34 cases of asthenospermia. The changes of NO concentration and SOD activity before and after the treatment with Jujingwan were observed.
  
  
  RESULTS
  Compared with pre-treatment, there was no significant change in NO concentration, and the activity of SOD decreased significantly after the treatment ([95.97 +/- 20.75] microg/L vs [6.14 +/- 19.99] microg/L). There was negative correlation between NO concentration and SOD activity before the treatment (r = -0.246, P < 0.05).
  
  
  CONCLUSIONS
  Jujingwan can significantly improve sperm viability in patients with asthenospermia. However, the excellent effects of Jujingwan are not displayed in the changes of NO concentration and SOD activity.
authors.affiliation: Laboratory of Reproduction & Genetics, PIA Institute of Clinical Laboratory Medicine, Nanjing General Hospital of Nanjing Command, PLA, Nanjing, Jiangsu, China. hexiking@126.com
authors.forename: Bao-fang
authors.initials: BF
authors.lastname: Jin
authors.forename: Xiao-yu
authors.initials: XY
authors.lastname: Yang
authors.forename: Ting-song
authors.initials: TS
authors.lastname: Bian
authors.forename: Xiang
authors.initials: X
authors.lastname: Zhou
authors.forename: Yu-feng
authors.initials: YF
authors.lastname: Huang
authors.forename: Xiu-lai
authors.initials: XL
authors.lastname: Wang
authors.forename: Zuo-min
authors.initials: ZM
authors.lastname: Zhou
authors.forename: Fu-song
authors.initials: FS
authors.lastname: Xu
mesh_terms: D000328:Adult; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000378:metabolism*; D009845:Oligospermia / Q000188:drug therapy* / Q000378:metabolism; D008517:Phytotherapy; D012661:Semen / Q000737:chemistry*; D013076:Sperm Count; D013081:Sperm Motility / Q000187:drug effects; D013482:Superoxide Dismutase / Q000378:metabolism*
chemical_list: D004365:Drugs, Chinese Herbal; D009569:Nitric Oxide; D013482:Superoxide Dismutase