Prevalence of early and late age-related macular degeneration in a rural population in northern India: the INDEYE feasibility study.
OBJECTIVE
To assess the prevalence of age-related macular degeneration (AMD) in a rural population in Northern India.


METHODS
In a pilot feasibility study, 1443 people (median age, 60 years; 52% women), were identified from enumeration of the 50+ age group in 11 randomly sampled villages from a rural, periurban district of Haryana, Northern India. Of those identified, 87% attended an eye examination that included digital fundus photography. Fundus images were graded at a single reading center using definitions from the Wisconsin Age-Related Maculopathy Grading System.


RESULTS
Fundus photographs were available for 1101 participants. Overall, 28.8% of participants had ungradable fundus images due to cataract. Including all with ungradable images in the denominator, the prevalence of soft drusen was 34.0% (95% confidence interval [CI] 26.1-42.9); of soft indistinct drusen, 2.2% (95% CI, 1.1-4.4); and of pigmentary irregularities, 10.8% (95% CI, 7.1-16.1). There were 15 (1.4%) cases of late-stage AMD (95% CI, 0.8-2.3) with the prevalence rising from 0.4% in the 50- to 59-year age range to 4.6% in those aged 70 years or older.


CONCLUSIONS
Drusen and pigmentary irregularities are common among the rural northern Indian population. The prevalence of late AMD is similar to that encountered in Western settings and is likely to contribute significantly to the burden of vision loss in older people in the developing world.
Gupta
Sanjeev K
SK
Department of Community Ophthalmology, Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.
Murthy
Gudlavalleti V S
GV
Morrison
Nicoli
N
Price
Gill M
GM
Dherani
Mukesh
M
John
Neena
N
Fletcher
Astrid E
AE
Chakravarthy
Usha
U
D017677:Age Distribution; D000368:Aged; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D007194:India / Q000453:epidemiology; D008268:Macular Degeneration / Q000145:classification / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D010781:Photography; D010865:Pilot Projects; D015995:Prevalence; D012307:Risk Factors; D012424:Rural Population / Q000706:statistics & numerical data*; D017678:Sex Distribution