title: Modern management of vestibular schwannomas.
abstract: Within the last 3 decades, microsurgery and stereotactic radiosurgery (SRS) have become well-established management options for vestibular schwannomas (VSs). Advancement in the management of VSs can be separated into three periods: the microsurgical pioneer period, the demonstration of SRS as a first-line therapy for small and medium-sized VSs, and currently, a period of SRS maturity based on a large worldwide patient accrual. The Marseille SRS experience includes 1,500 patients, with 1,000 patients having follow-up longer than 3 years. A long-term tumor control rate of 97%, transient facial palsy lower than 1%, and a probability of functional hearing preservation between 50 and 95% was achieved in this large series of patients treated with state-of-the-art SRS.
authors.affiliation: Departments of Functional Neurosurgery and ENT Surgery, Timone University Hospital, and Skull Base Neurosurgery Department, Sainte Marguerite, Marseille, France.
authors.forename: Jean
authors.initials: J
authors.lastname: Régis
authors.forename: Pierre Hughes
authors.initials: PH
authors.lastname: Roche
authors.forename: Christine
authors.initials: C
authors.lastname: Delsanti
authors.forename: Jean Marc
authors.initials: JM
authors.lastname: Thomassin
authors.forename: Maurice
authors.initials: M
authors.lastname: Ouaknine
authors.forename: Karin
authors.initials: K
authors.lastname: Gabert
authors.forename: William
authors.initials: W
authors.lastname: Pellet
mesh_terms: D005158:Facial Paralysis / Q000209:etiology / Q000517:prevention & control; D006801:Humans; D006849:Hydrocephalus / Q000209:etiology; D008866:Microsurgery; D009422:Nervous System Diseases / Q000209:etiology; D016518:Neurofibromatosis 2 / Q000209:etiology; D009464:Neuroma, Acoustic / Q000473:pathology / Q000601:surgery*; D011183:Postoperative Complications / Q000453:epidemiology*; D016634:Radiosurgery / Q000009:adverse effects; D016896:Treatment Outcome; D014722:Vestibule, Labyrinth / Q000528:radiation effects