title: Epigenetics: a landscape takes shape.
abstract: Epigenetics has recently evolved from a collection of diverse phenomena to a defined and far-reaching field of study. In this Essay, we examine the epistemology of epigenetics, provide a brief overview of underlying molecular mechanisms, and suggest future challenges for the field.
authors.affiliation: Laboratory of Chromatin Biology, The Rockefeller University, New York, NY 10021, USA.
authors.forename: Aaron D
authors.initials: AD
authors.lastname: Goldberg
authors.forename: C David
authors.initials: CD
authors.lastname: Allis
authors.forename: Emily
authors.initials: E
authors.lastname: Bernstein
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000235:genetics*; D002455:Cell Division / Q000235:genetics*; D042002:Chromatin Assembly and Disassembly / Q000235:genetics; D019175:DNA Methylation; D044127:Epigenesis, Genetic / Q000235:genetics*; D005786:Gene Expression Regulation / Q000235:genetics*; D006657:Histones / Q000235:genetics / Q000378:metabolism; D006801:Humans; D022661:RNA, Untranslated / Q000235:genetics
chemical_list: D006657:Histones; D022661:RNA, Untranslated