title: Adjuvant and neoadjuvant therapies in high risk localized prostate cancer.
abstract: In this review article adjuvant and neoadjuvant therapies in patients at high risk for localized prostate cancer are presented in some detail. Adjuvant hormone therapy by antiandrogens as well as antineoplastic chemotherapeutic agents such as estramustine and taxanes are referred. Neoadjuvant therapies in addition to systemic therapy before or after local treatment for prostate cancer may improve the outcome of high risk patients otherwise destined to treatment fail. Data regarding some substances used in neoadjuvant therapies such as androgen deprivation therapy and use of rapamycin with its analogs, as well as some novel therapeutic approach strategies are also discussed.
authors.affiliation: Department of Urology, Medical Faculty, Clinical Unit, University of Ioannina, Ioannina, Greece.
authors.forename: X
authors.initials: X
authors.lastname: Giannakopoulos
authors.forename: D
authors.initials: D
authors.lastname: Stagikas
authors.forename: A
authors.initials: A
authors.lastname: Charalabopoulos
authors.forename: N
authors.initials: N
authors.lastname: Sofikitis
authors.forename: K
authors.initials: K
authors.lastname: Charalabopoulos
mesh_terms: D000726:Androgen Antagonists / Q000627:therapeutic use; D017024:Chemotherapy, Adjuvant; D006801:Humans; D008297:Male; D020360:Neoadjuvant Therapy; D011471:Prostatic Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000601:surgery / Q000628:therapy*; D018714:Radiotherapy, Adjuvant
chemical_list: D000726:Androgen Antagonists