title: Coumarins from Cnidium monnieri and their antiosteoporotic activity.
abstract: Bioactivity-guided fractionation has led to the successful isolation of antiosteoporotic components, i. e., osthole, imperatorin and bergapten from an ethanolic extract of the fruits of Cnidium monnieri (L.) Cusson. Among them, osthole was determined as the major compound possessing antiosteoporotic activity. Further study showed that osthole not only promoted the proliferation and activity of alkaline phosphatase of osteoblasts in neonatal calvaria cultures, but also inhibited the bone resorption by decreasing the formation, differentiation and TRAP activity of osteoclasts derived from rat marrow cells.
authors.affiliation: Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, Shanghai, China.
authors.forename: Qiaoyan
authors.initials: Q
authors.lastname: Zhang
authors.forename: Luping
authors.initials: L
authors.lastname: Qin
authors.forename: Weidong
authors.initials: W
authors.lastname: He
authors.forename: Luc
authors.initials: L
authors.lastname: Van Puyvelde
authors.forename: Dominick
authors.initials: D
authors.lastname: Maes
authors.forename: An
authors.initials: A
authors.lastname: Adams
authors.forename: Hanchen
authors.initials: H
authors.lastname: Zheng
authors.forename: Norbert
authors.initials: N
authors.lastname: De Kimpe
mesh_terms: D000469:Alkaline Phosphatase / Q000096:biosynthesis; D000818:Animals; D001854:Bone Marrow Cells / Q000187:drug effects / Q000378:metabolism; D049109:Cell Proliferation / Q000187:drug effects*; D031048:Cnidium; D004305:Dose-Response Relationship, Drug; D005638:Fruit; D010006:Osteoblasts / Q000187:drug effects* / Q000378:metabolism; D010024:Osteoporosis / Q000188:drug therapy; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar
chemical_list: D010936:Plant Extracts; D000469:Alkaline Phosphatase