title: A new 2,3-dimethyl butenolide from the brittle star Ophiomastix mixta.
abstract: A new butenolide (1) was isolated, along with a known acyclic polyhalogenated monoterpene (2), from the brittle star Ophiomastix mixta. The structures were defined by analysis and comparision of the spectral data with those in the literature. The 2,3-dimethyl butenolide (1) is uncommon and first encountered in a marine organism. The compounds were tested for cytotoxicity against a panel of five human solid tumor cell lines and displayed mild to significant activity.
authors.affiliation: College of Pharmacy, Pusan National University, Busan, Korea.
authors.forename: Jinsoo
authors.initials: J
authors.lastname: Lee
authors.forename: Weihong
authors.initials: W
authors.lastname: Wang
authors.forename: Jongki
authors.initials: J
authors.lastname: Hong
authors.forename: Chong-Ok
authors.initials: CO
authors.lastname: Lee
authors.forename: Sook
authors.initials: S
authors.lastname: Shin
authors.forename: Kwang Sik
authors.initials: KS
authors.lastname: Im
authors.forename: Jee Hyung
authors.initials: JH
authors.lastname: Jung
mesh_terms: D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000737:chemistry* / Q000378:metabolism; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D004447:Echinodermata / Q000737:chemistry* / Q000378:metabolism*; D006801:Humans; D015394:Molecular Structure
chemical_list: D000970:Antineoplastic Agents; D015107:4-Butyrolactone