title: Enhancing the tolerance of poly(isobutylcyanoacrylate) nanoparticles with a modular surface design.
abstract: Polymer nanoparticles are designed as nanovehicles to carry drugs in the body in a controlled manner increasing the concentration of the biologically active substance in the diseased organs and cells. The safety and biocompatibility of these nanosystems are those of the many properties that nanoparticles must meet to be used in vivo. Here we show that the cytotoxicity profile of poly(isobutylcyanoacrylate) (PIBCA) nanoparticles is affected by the way the nanosystems were produced and by the design of their surface. It was found that the tolerance of PIBCA nanoparticles by cells could be improved up to 100-fold by coating their surface with polysaccharides and haemoglobin.
authors.affiliation: INSERM U779, Hôpital de Bicêtre, Secteur Broca, 78 rue du Général Leclerc, 94275 Le Kremlin-Bicêtre, France.
authors.forename: Cédric
authors.initials: C
authors.lastname: Chauvierre
authors.forename: Liliane
authors.initials: L
authors.lastname: Leclerc
authors.forename: Denis
authors.initials: D
authors.lastname: Labarre
authors.forename: Martine
authors.initials: M
authors.lastname: Appel
authors.forename: Michael C
authors.initials: MC
authors.lastname: Marden
authors.forename: Patrick
authors.initials: P
authors.lastname: Couvreur
authors.forename: Christine
authors.initials: C
authors.lastname: Vauthier
mesh_terms: D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D003487:Cyanoacrylates / Q000737:chemistry* / Q000633:toxicity; D003911:Dextrans / Q000737:chemistry*; D004659:Enbucrilate; D007941:Leukemia P388 / Q000473:pathology; D051379:Mice; D053758:Nanoparticles / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry* / Q000633:toxicity; D013499:Surface Properties
chemical_list: D003487:Cyanoacrylates; D003911:Dextrans; D011108:Polymers; D004659:Enbucrilate