HuR-SIRT: the hairy world of posttranscriptional control.
In this issue of Molecular Cell, demonstrate that the RNA binding protein HuR selectively up- or downregulates the stability of the SIRT1 mRNA (which encodes an important regulatory deacetylase) depending upon phosphorylation by Chk2.
Wilusz
Carol J
CJ
Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA.
Wilusz
Jeffrey
J
D000954:Antigens, Surface / Q000378:metabolism*; D064447:Checkpoint Kinase 2; D051959:ELAV Proteins; D000067780:ELAV-Like Protein 1; D005786:Gene Expression Regulation; D006367:HeLa Cells; D006801:Humans; D010766:Phosphorylation; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism; D020871:RNA Stability; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D016601:RNA-Binding Proteins / Q000378:metabolism*; D056564:Sirtuin 1; D037761:Sirtuins / Q000235:genetics* / Q000378:metabolism*
D000954:Antigens, Surface; D051959:ELAV Proteins; D000067780:ELAV-Like Protein 1; C098770:ELAVL1 protein, human; D012333:RNA, Messenger; D016601:RNA-Binding Proteins; D064447:Checkpoint Kinase 2; C578634:CHEK2 protein, human; D017346:Protein Serine-Threonine Kinases; C447939:SIRT1 protein, human; D056564:Sirtuin 1; D037761:Sirtuins