title: Evaluation of cognitive functioning in 101 patients before opiate detoxification: implications in setting up therapeutic strategies.
abstract: Many studies have brought to light the facts that repeated use of drugs significantly influences one's cognitive functions, and that cognitive problems could interfere directly with one's capacity to participate in a rehabilitation program. In this research, we used the Global Deterioration Scale (GDS) to assess the cognitive status of 101 hospitalized patients in an opiate detoxification program. The results reveal that a majority of the tested patients present cognitive abnormalities to varying degrees of severity. Furthermore, these cognitive deficits are correlated with four Addiction Severity Index (ASI) scales (medical, alcohol use, drug use, and psychiatry, respectively). Considering the results, because cognition is a major issue in detoxification and rehabilitation programs, simple cognitive screening (as with the GDS) coupled with a particular interest in some aspects of a patient's anamnesis could lead to better management of opiate-dependent patients.
authors.affiliation: Université Libre de Bruxelles, Service de Psychiatrie, Clinique d'Alcoologie & Toxicomanies, Brussels, Belgium.
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Streel
authors.forename: Valérie
authors.initials: V
authors.lastname: Antoniali
authors.forename: Salvatore
authors.initials: S
authors.lastname: Campanella
authors.forename: Julie
authors.initials: J
authors.lastname: Castronovo
authors.forename: Catherine
authors.initials: C
authors.lastname: Hanak
authors.forename: Isy
authors.initials: I
authors.lastname: Pelc
authors.forename: Paul
authors.initials: P
authors.lastname: Verbanck
mesh_terms: D000293:Adolescent; D000328:Adult; D003000:Clonidine / Q000008:administration & dosage / Q000627:therapeutic use*; D003072:Cognition Disorders / Q000209:etiology / Q000523:psychology*; D005260:Female; D006801:Humans; D008297:Male; D008691:Methadone / Q000008:administration & dosage*; D008875:Middle Aged; D009292:Narcotic Antagonists / Q000008:administration & dosage / Q000627:therapeutic use*; D009483:Neuropsychological Tests; D009293:Opioid-Related Disorders / Q000188:drug therapy / Q000523:psychology* / Q000534:rehabilitation; D012720:Severity of Illness Index
chemical_list: D009292:Narcotic Antagonists; D003000:Clonidine; D008691:Methadone