Distribution and significance of endothelin 1 in guinea pig cochlear lateral wall.
Endothelin 1 is a vasoconstrictive peptide with many biological functions. To investigate the distribution of endothelin 1 in guinea pig cochlear lateral wall and the significance of endothelin 1 in maintaining cochlear homeostasis, the immunohistochemistry avidin biotin complex method was applied by using rabbit anti-endothelin 1 polyclonal antibody as primary antibody. Endothelin-1-like activities were detected in the marginal cells, spiral prominence epithelial cells, outer sulcus cells, stria vascularis capillaries, basal cells and spiral ligament fibrocytes. These results suggest that endothelin 1 may play an important role in maintaining cochlear homeostasis.
Xu
D-Y
DY
Department of Otorhinolaryngology, West China Hospital of Sichuan University, Chengdu, China.
Tang
Y-D
YD
Liu
S-X
SX
Liu
J
J
D000818:Animals; D003051:Cochlea / Q000737:chemistry*; D019332:Endothelin-1 / Q000032:analysis* / Q000502:physiology; D006168:Guinea Pigs; D011817:Rabbits
D019332:Endothelin-1