Lamivudine-associated macrocytosis in HIV-infected patients.
Macrocytosis has been increasingly observed in HIV-infected population and is an early indicator of bone marrow toxicity. A retrospective study was conducted among these patients in a HIV clinic to assess risk factors of macrocytosis. We found that lamivudine was strongly associated with macrocytosis (OR = 24.6 [2.9-3223.0], P = 0.001). This association may be due to lamivudine's effect on erythrocyte synthesis.
Khawcharoenporn
Thana
T
Department of Medicine, University of Hawaii, Honolulu, Hawaii, HI 96813, USA. thanak30@yahoo.com
Shikuma
Cecilia M
CM
Williams
Andrew E
AE
Chow
Dominic C
DC
D000328:Adult; D000748:Anemia, Macrocytic / Q000097:blood / Q000139:chemically induced*; D004909:Erythrocyte Indices / Q000187:drug effects; D005260:Female; D006678:HIV; D015658:HIV Infections / Q000097:blood / Q000188:drug therapy*; D006801:Humans; D019259:Lamivudine / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies
D019259:Lamivudine