title: Attenuation-corrected vs. nonattenuation-corrected 2-deoxy-2-[F-18]fluoro-D-glucose-positron emission tomography in oncology: a systematic review.
abstract: OBJECTIVE
  To perform a systematic review and meta-analysis to determine the diagnostic accuracy of attenuation-corrected (AC) vs. nonattenuation-corrected (NAC) 2-deoxy-2-[F-18]fluoro-D-glucose-positron emission tomography (FDG-PET) in oncological patients.
  
  
  METHODS
  Following a comprehensive search of the literature, two reviewers independently assessed the methodological quality of eligible studies. The diagnostic value of AC was studied through its sensitivity/specificity compared to histology, and by comparing the relative lesion detection rate reported with NAC-PET vs. AC, for full-ring and dual-head coincidence PET (FR- and DH-PET, respectively).
  
  
  RESULTS
  Twelve studies were included. For FR-PET, the pooled sensitivity/specificity on a patient basis was 64/97% for AC and 62/99% for NAC, respectively. Pooled lesion detection with NAC vs. AC was 98% [95% confidence interval (95% CI): 96-99%, n = 1,012 lesions] for FR-PET, and 88% (95% CI:81-94%, n = 288 lesions) for DH-PET.
  
  
  CONCLUSIONS
  Findings suggest similar sensitivity/specificity and lesion detection for NAC vs. AC FR-PET and significantly higher lesion detection for NAC vs. AC DH-PET.
authors.affiliation: Department of Nuclear Medicine and PET Research, VU University Medical Centre, 1117 De Boelelaan, Amsterdam, The Netherlands.
authors.forename: Urvi
authors.initials: U
authors.lastname: Joshi
authors.forename: Pieter G H M
authors.initials: PG
authors.lastname: Raijmakers
authors.forename: Ingrid I
authors.initials: II
authors.lastname: Riphagen
authors.forename: Gerrit J J
authors.initials: GJ
authors.lastname: Teule
authors.forename: Arthur
authors.initials: A
authors.lastname: van Lingen
authors.forename: Otto S
authors.initials: OS
authors.lastname: Hoekstra
mesh_terms: D019788:Fluorodeoxyglucose F18; D006801:Humans; D009369:Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D049268:Positron-Emission Tomography / Q000379:methods* / Q000706:statistics & numerical data; D019275:Radiopharmaceuticals; D012680:Sensitivity and Specificity
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18