Recording of focal direct current (DC) changes in the human cerebral cortex using refined non-invasive DC-EEG methodology.
A non-invasive DC electroencephalographic (DC-EEG) method was developed to record and analyze focal low-frequency (<0.1 Hz) DC changes in the human cerebral cortex. A simple repetitive finger-movement task was used as a physiological activation paradigm. DC-EEG amplitudes were recorded using a custom-made DC amplifier with automatic offset correction. A total of 16 standard Ag/AgCl electrodes covered the left primary motor cortex. In three of six subjects, reliable focal motor-related DC-EEG shifts over the hand cortex were monitored. This study demonstrates that refined DC-EEG recording and data analysis procedures allow non-invasive recording of low-frequency and low-amplitude focal cortical changes in humans. An important clinical perspective of this technology is the detection of stroke-associated cortical DC activity.
Leistner
Stefanie
S
Neurophysics Group, Department of Neurology, Campus Benjamin Franklin, Charité- University Medicine Berlin, Berlin, Germany. stefanie.leistner@charite.de
Scheer
Hans-Juergen
HJ
Sander
Tilmann
T
Burghoff
Martin
M
Trahms
Lutz
L
Curio
Gabriel
G
Mackert
Bruno-Marcel
BM
D000465:Algorithms; D000669:Amplifiers, Electronic; D003936:Diagnosis, Computer-Assisted / Q000379:methods; D004569:Electroencephalography / Q000295:instrumentation* / Q000379:methods; D004867:Equipment Design; D019544:Equipment Failure Analysis; D019054:Evoked Potentials, Motor / Q000502:physiology*; D005240:Feasibility Studies; D006801:Humans; D008991:Monitoring, Physiologic / Q000295:instrumentation* / Q000379:methods; D009044:Motor Cortex / Q000502:physiology*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity