Enrofloxacin-induced retinopathy in a guanaco (Lama guanicoe).
A 4-yr-old male guanaco (Lama guanicoe) in a multispecies exhibit presented with a laceration in the axillary region. The laceration was surgically repaired. Medical treatment was initiated with penicillin G procaine and benzathine (1920 IU/kg, i.m., s.i.d. for 14 days), and enrofloxacin (2.4 mg/kg, i.m., s.i.d. for 14 days). The animal was later treated with trimethoprim-sulfadiazine (24 mg/kg, p.o., s.i.d. for 10 days). Twenty-six days after initial presentation, the guanaco was suspected to be blind. An ophthalmic examination confirmed retinal damage. On postmortem histological evaluation, there was outer retinal atrophy that was most severe in the central retina with localized foci of complete retinal atrophy; lesions were similar to those observed in enrofloxacin retinal toxicity in cats.
Harrison
Tara M
TM
Wildlife Safari 1790 Safari Road, Winston, Oregon 97496, USA.
Dubielzig
Richard R
RR
Harrison
Timothy R
TR
McClean
Modesto
M
D000818:Animals; D000835:Animals, Wild; D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000627:therapeutic use; D002161:Camelids, New World; D000077422:Enrofloxacin; D024841:Fluoroquinolones / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D012162:Retinal Degeneration / Q000139:chemically induced / Q000662:veterinary*
D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones; D000077422:Enrofloxacin