title: Influence of crosslinking agents on the pore structure of skin.
abstract: Analysis of pore structure of skin is important to understand process of diffusion and adsorption involved during any application of the skin matrix. In this study, the effect of thermal shrinkage on the pore structure of chromium and vegetable treated skin has been analyzed as these tanning agents are known to bring about thermal stability to the matrix. The changes brought about in the pore structure have been studied using mercury intrusion porosimetry and scanning electron microscopy. Response of the chromium treated and vegetable tanning treated skin structure to heat has been found to be quite different from each other. About 41% decrease in porosity is observed for chromium treated skin as against 97% decrease for the skin treated with vegetable tannins. This is primarily attributed to the basic nature of these materials and the nature of interaction of them towards skin.
authors.affiliation: Chemical Laboratory, Central Leather Research Institute, Adyar, Chennai 600020, India.
authors.forename: N Nishad
authors.initials: NN
authors.lastname: Fathima
authors.forename: Aruna
authors.initials: A
authors.lastname: Dhathathreyan
authors.forename: T
authors.initials: T
authors.lastname: Ramasami
mesh_terms: D000818:Animals; D002417:Cattle; D002857:Chromium / Q000494:pharmacology; D003432:Cross-Linking Reagents / Q000494:pharmacology*; D066298:In Vitro Techniques; D008628:Mercury; D008855:Microscopy, Electron, Scanning; D016062:Porosity; D012867:Skin / Q000187:drug effects* / Q000648:ultrastructure; D013633:Tanning; D013634:Tannins / Q000494:pharmacology
chemical_list: D003432:Cross-Linking Reagents; D013634:Tannins; D002857:Chromium; D008628:Mercury