Gene polymorphisms and behavior.
Genetics has a entered golden post genomic era that promises to greatly improve our understanding of the etiology of complex familial disorders. Many forms of behavior are familial but Mendelian disorders are rare, and common conditions have complex inheritance. Twin and adoption studies confirm that major psychiatric disorders such as schizophrenia and bipolar affective disorder are highly heritable. There is also emerging evidence of some overlap between these disorders. Several susceptibility loci for schizophrenia have been identified, at least one of which is also a susceptibility gene for bipolar disorder. The first susceptibility genes involved in major psychiatric disorders have been identified and more will soon follow with the exploitation of emerging technologies that allow whole genome association studies.
McGuffin
Peter
P
Medical Research Council (MRC) Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, Kings College London, London, United Kingdom. p.mcguffin@iop.kcl.ac.uk
D000300:Adoption / Q000523:psychology; D020022:Genetic Predisposition to Disease; D005824:Genetics, Behavioral; D006801:Humans; D015810:Linkage Disequilibrium; D001523:Mental Disorders / Q000235:genetics*; D011110:Polymorphism, Genetic; D018433:Twin Studies as Topic