title: [Sepsis in the critically-ill patient].
abstract: SIRS, sepsis, severe sepsis, and septic shock are complex syndromes ranging from early signs of infection to multiple organ dysfunction and shock. The reported incidence of sepsis is as high as 35% with mortality rates from 27% to 54% in sepsis and septic shock, respectively. Though aetiology and pathogenesis can vary significantly between septic patients, emphasis has been made to preserve sepsis as a clinical diagnosis ensuring high sensitivity. Since 2001 several new treatment strategies have been implemented, but early diagnosis, optimization of haemodynamics, rapid identification of pathogen and adequate antibiotic treatment are still of the highest importance.
authors.affiliation: Rigshospitalet, Paediatrisk klinik, Juliane Marie Center.
authors.forename: Vibeke Brix
authors.initials: VB
authors.lastname: Christensen
authors.forename: Jeppe Sylvest
authors.initials: JS
authors.lastname: Nielsen
authors.forename: Else K
authors.initials: EK
authors.lastname: Tønnesen
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D003422:Critical Care / Q000379:methods*; D016638:Critical Illness / Q000401:mortality / Q000628:therapy*; D006801:Humans; D018805:Sepsis / Q000188:drug therapy* / Q000382:microbiology / Q000401:mortality; D012772:Shock, Septic / Q000188:drug therapy* / Q000382:microbiology / Q000401:mortality; D018746:Systemic Inflammatory Response Syndrome / Q000188:drug therapy* / Q000382:microbiology / Q000401:mortality; D013997:Time Factors
chemical_list: D000305:Adrenal Cortex Hormones; D000900:Anti-Bacterial Agents