title: Synthesis and evaluation of a pseudocyclic tristhiourea-based anion host.
abstract: A novel methodology for the evaluation of receptor arrangement in structurally flexible anion chemosensors was developed and applied to map the binding site of a new pseudocyclic tristhiourea chemosensor (6). The syntheses of 6 and related macrocyclic chemosensor 10 (a model of the folded monomeric structure of 6) are reported. Both chemosensors were evaluated by titration with a variety of structurally different anions in CH3Cl and DMSO, showing a common preference for F-, CH3CO2-, and H2PO4-. However, within this group of anions, the binding patterns of the chemosensors differed, indicating dissimilarity in the arrangement of the binding sites of 6 and 10.
authors.affiliation: School of Chemistry, Raymond and Beverly Sackler Faculty of Exact Sciences, Tel Aviv University, Tel Aviv 69978, Israel.
authors.forename: Adi
authors.initials: A
authors.lastname: Dahan
authors.forename: Tali
authors.initials: T
authors.lastname: Ashkenazi
authors.forename: Vladimir
authors.initials: V
authors.lastname: Kuznetsov
authors.forename: Svetlana
authors.initials: S
authors.lastname: Makievski
authors.forename: Eyal
authors.initials: E
authors.lastname: Drug
authors.forename: Ludmila
authors.initials: L
authors.lastname: Fadeev
authors.forename: Maayan
authors.initials: M
authors.lastname: Bramson
authors.forename: Sari
authors.initials: S
authors.lastname: Schokoroy
authors.forename: Emily
authors.initials: E
authors.lastname: Rozenshine-Kemelmakher
authors.forename: Michael
authors.initials: M
authors.lastname: Gozin
mesh_terms: D000838:Anions / Q000737:chemistry*; D003500:Cyclization; D019281:Dimerization; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D008968:Molecular Conformation; D010777:Photochemistry; D013890:Thiourea / Q000737:chemistry*; D017186:Titrimetry
chemical_list: D000838:Anions; D013890:Thiourea