title: Formin the way.
abstract: Reorganization of the actin cytoskeleton requires nucleating factors, which initiate actin fiber formation. In this issue of Immunity, the functions of two classes of actin nucleators are examined in T lymphocytes, giving insight into the regulation of T cell polarity (Gomez et al., 2007).
authors.affiliation: National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA. pams@mail.nih.gov
authors.forename: Pamela L
authors.initials: PL
authors.lastname: Schwartzberg
mesh_terms: D051376:Actin-Related Protein 2-3 Complex / Q000276:immunology / Q000378:metabolism; D000199:Actins / Q000378:metabolism*; D048868:Adaptor Proteins, Signal Transducing / Q000276:immunology / Q000378:metabolism; D000818:Animals; D016764:Cell Polarity / Q000276:immunology*; D003598:Cytoskeletal Proteins / Q000276:immunology* / Q000378:metabolism; D003599:Cytoskeleton; D000080865:Formins; D006801:Humans; D008213:Lymphocyte Activation / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism
chemical_list: D051376:Actin-Related Protein 2-3 Complex; D000199:Actins; D048868:Adaptor Proteins, Signal Transducing; D003598:Cytoskeletal Proteins; C108962:DIAPH1 protein, human; C476204:FMNL1 protein, human; D000080865:Formins