title: Normo or hypobaric hypoxic tests: propositions for the determination of the individual susceptibility to altitude illnesses.
abstract: Assessment of individual susceptibility to altitude illnesses and more particularly to acute mountain sickness (AMS) by means of tests performed in normobaric hypoxia (NH) or in hypobaric hypoxia (HH) is still debated. Eighteen subjects were submitted to HH and NH tests (PIO2=120 hPa, 30 min) before an expedition. Maximal and mean acute mountain sickness scores (AMSmax and mean) were determined using the self-report Lake Louise questionnaire scored daily. Cardio-ventilatory (f, V(T), PetO2 and PetCO2, HR and finger pulse oxymetry SpO2) were measured at times 5 and 30 min of the tests. Arterial (PaO2, PaCO2, pH, SaO2) and capillary haemoglobin (Hb) measurements were performed at times 30 min. Hypoxic ventilatory (HVR) and cardiac (HCR) responses, peripheral O2 blood content (CpO2) were calculated. A significant time effect is found for DeltaSpO2 (P = 0.04). Lower PaCO2 (P = 0.005), SaO2 (P = 0.07) and higher pH (P = 0.02) are observed in HH compared to NH. AMSmax varied from 3 to12 and AMSmean between 0.6 and 3.5. In NH at 30 min, AMSmax is related to PetO2 (R = 0.61, P = 0.03), CpO2 (R = -0.53, P = 0.02) and in HH to CpO2 (R = -0.57, P = 0.01). In NH, AMSmean is related to Deltaf (R = 0.46, P = 0.05), HCR (R = 0.49, P = 0.04), CpO2 (R = -0.51, P = 0.03) and, in HH at 30 min, to V(T) (R = 0.69, P = 0.01) and a tendency for CpO2 (R = -0.43, P = 0.07). We conclude that HH and NH tests are physiologically different and they must last 30 min. CpO2 is an important variable to predict AMS. For practical considerations, NH test is proposed to quantify AMS individual susceptibility using the formulas: AMSmax = 9.47 + 0.104PetO2(hPa)-0.68CpO2 (%), (R = 0.77, P = 0.001); and AMSmean = 3.91 + 0.059Deltaf + 0.438HCR-0.135CpO2 (R = 0.71, P = 0.017).
authors.affiliation: Département des Facteurs humains, Pôle tolérance climatique et vêtement, Centre de recherches du service de santé des armées, BP 87 38702, La Tronche cedex, France. gsavourey@crssa.net
authors.forename: Gustave
authors.initials: G
authors.lastname: Savourey
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Launay
authors.forename: Yves
authors.initials: Y
authors.lastname: Besnard
authors.forename: Angélique
authors.initials: A
authors.lastname: Guinet-Lebreton
authors.forename: Antonia
authors.initials: A
authors.lastname: Alonso
authors.forename: Fabien
authors.initials: F
authors.lastname: Sauvet
authors.forename: Cyprien
authors.initials: C
authors.lastname: Bourrilhon
mesh_terms: D000064:Acclimatization / Q000502:physiology*; D000328:Adult; D000532:Altitude Sickness / Q000175:diagnosis* / Q000378:metabolism / Q000503:physiopathology*; D001274:Atmospheric Pressure; D002245:Carbon Dioxide / Q000097:blood; D004198:Disease Susceptibility / Q000175:diagnosis*; D005260:Female; D006262:Health; D006801:Humans; D000860:Hypoxia / Q000503:physiopathology*; D008297:Male; D008991:Monitoring, Physiologic; D010100:Oxygen / Q000097:blood; D010313:Partial Pressure; D012129:Respiratory Function Tests
chemical_list: D002245:Carbon Dioxide; D010100:Oxygen