Influence of the formulation on the tolerance profile of nanoparticle-bound doxorubicin in healthy rats: focus on cardio- and testicular toxicity.
A toxicological study of doxorubicin bound to poly(butyl cyanoacrylate) or human serum albumin nanoparticles coated with polysorbate 80 was performed in healthy rats. The doxorubicin formulations were injected at a therapeutic dose regimen (3 x 1.5 mg/kg with a 72 h interval), and the animals were followed up for 15 or 30 days. The overall result of this study suggests that the surfactant-coated nanoparticle formulations of doxorubicin have favorable toxicological profiles. Specifically, these formulations display a considerably reduced cardio- and testicular toxicity, as compared to a free drug.
Pereverzeva
E
E
Gauze Institute of Novel Antibiotics, Academy of Medical Sciences, Moscow, Russia.
Treschalin
I
I
Bodyagin
D
D
Maksimenko
O
O
Langer
K
K
Dreis
S
S
Asmussen
B
B
Kreuter
J
J
Gelperina
S
S
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000737:chemistry / Q000633:toxicity*; D001772:Blood Cell Count; D001835:Body Weight / Q000187:drug effects; D002626:Chemistry, Pharmaceutical; D004317:Doxorubicin / Q000737:chemistry / Q000633:toxicity*; D004337:Drug Carriers; D004339:Drug Compounding; D004659:Enbucrilate / Q000737:chemistry*; D006321:Heart / Q000187:drug effects* / Q000503:physiopathology; D008133:Long QT Syndrome / Q000139:chemically induced; D008297:Male; D009206:Myocardium / Q000473:pathology; D053758:Nanoparticles; D009929:Organ Size / Q000187:drug effects; D011136:Polysorbates / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D012709:Serum Albumin / Q000737:chemistry*; D013501:Surface-Active Agents / Q000737:chemistry; D013610:Tachycardia / Q000139:chemically induced; D013737:Testis / Q000187:drug effects* / Q000473:pathology; D013997:Time Factors
D000903:Antibiotics, Antineoplastic; D004337:Drug Carriers; D011136:Polysorbates; D012709:Serum Albumin; D013501:Surface-Active Agents; D004317:Doxorubicin; D004659:Enbucrilate