title: Peripapillary atrophy after acute primary angle closure.
abstract: OBJECTIVE
  To determine the changes in peripapillary atrophy after episodes of acute primary angle closure (APAC).
  
  
  METHODS
  Prospective observational study of 40 eyes in 38 patients of predominantly Chinese ethnicity. The mean (SD) intraocular pressure at the time of presentation was 51.7 (12) mm Hg (median, 55 mm Hg) and the mean duration of the symptoms was 37.7 (69.4) hours. A laser iridotomy was undertaken 3.2 (8.4) days after the APAC episode, leading to normalisation of intraocular pressure in all cases. Colour optic disc photographs taken at 2 and 16 weeks after APAC were examined morphometrically. Peripapillary atrophy was divided into alpha and beta zones.
  
  
  RESULTS
  Comparing measurements at baseline with week 16, the minimum width of the alpha zone (0.013 (0.056) v 0.016 (0.001) arbitrary units; p = 0.23), the maximum width of the alpha zone (1.11 (1.31) v 1.31 (0.79) arbitrary units; p = 0.22), the minimum width of the beta zone (0.030 (0.122) v 0.033 (0.166) arbitrary units; p = 0.93), and the maximum width of the beta zone (0.62 (0.94) v 0.73 (0.98) arbitrary units; p = 0.42) did not vary significantly. The mean cup to disc ratio increased from 0.56 (0.05) to 0.62 (0.07) (p<0.0001) at the end of follow up.
  
  
  CONCLUSIONS
  The alpha and beta zones of peripapillary atrophy did not enlarge markedly in patients after APAC, despite an enlargement of the optic cup during a follow up of four months.
authors.affiliation: Glaucoma Department, Singapore National Eye Centre, 11 Third Hospital Avenue, Singapore 168751.
authors.forename: Kelvin Y C
authors.initials: KY
authors.lastname: Lee
authors.forename: Florian
authors.initials: F
authors.lastname: Rensch
authors.forename: Tin
authors.initials: T
authors.lastname: Aung
authors.forename: Laurence S
authors.initials: LS
authors.lastname: Lim
authors.forename: Rahat
authors.initials: R
authors.lastname: Husain
authors.forename: Gus
authors.initials: G
authors.lastname: Gazzard
authors.forename: Steve K L
authors.initials: SK
authors.lastname: Seah
authors.forename: Jost B
authors.initials: JB
authors.lastname: Jonas
mesh_terms: D000208:Acute Disease; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D015812:Glaucoma, Angle-Closure / Q000150:complications*; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D008875:Middle Aged; D009896:Optic Atrophy / Q000209:etiology*; D009898:Optic Disk / Q000473:pathology*; D011446:Prospective Studies