Mapping platypus SOX genes; autosomal location of SOX9 excludes it from sex determining role.
In the absence of an SRY orthologue the platypus sex determining gene is unknown, so genes in the human testis determining pathway are of particular interest as candidates. SOX9 is an attractive choice because SOX9 deletions cause male-to-female sex reversal in humans and mice, and SOX9 duplications cause female-to-male sex reversal. We have localized platypus SOX9, as well as the related SOX10, to platypus chromosomes 15 and 10, respectively, the first assignments to these platypus chromosomes, and the first comparative mapping markers from human chromosomes 17 and 22. The autosomal localization of platypus SOX9 in this study contradicts the hypothesis that SOX9 acts as the sex determining switch in platypus.
Wallis
M C
MC
Comparative Genomics Group, Research School of Biological Sciences, The Australian National University, Canberra, Australia.
Delbridge
M L
ML
Pask
A J
AJ
Alsop
A E
AE
Grutzner
F
F
O'Brien
P C M
PC
Rens
W
W
Ferguson-Smith
M A
MA
Graves
J A M
JA
D000818:Animals; D020223:Chromosome Painting; D022202:Chromosomes, Artificial, Bacterial; D033481:Chromosomes, Mammalian / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000235:genetics; D006609:High Mobility Group Proteins / Q000235:genetics*; D020161:Physical Chromosome Mapping; D010987:Platypus / Q000235:genetics*; D055758:SOX9 Transcription Factor; D055757:SOXE Transcription Factors; D019849:Sex Determination Processes; D014157:Transcription Factors / Q000235:genetics*
D004268:DNA-Binding Proteins; D006609:High Mobility Group Proteins; C527923:SOX10 protein, human; D055758:SOX9 Transcription Factor; C527932:SOX9 protein, human; D055757:SOXE Transcription Factors; C527924:Sox10 protein, mouse; C527933:Sox9 protein, mouse; D014157:Transcription Factors