title: Semi-artificial Fluorescent Molecular Machine for DNA Damage Detection.
abstract: The design of artificial molecular machines is complicated because the mechanics used in macromachines is not readily adaptable for nano environments. We constructed a semi-artificial molecular device, which contains a naturally occurring molecular machine-a vaccinia virus encoded protein-linked with an artificial part. The self-assembled construct makes two fluorescently labeled detector units. It is the first sensor capable of selectively detecting different types of DNA breaks, exemplifying a practical approach to the design of molecular devices.
authors.affiliation: Baylor College of Medicine, Houston, Texas, Michael E. DeBakey Veterans Affairs Medical Center, Houston, Texas, and Sloan-Kettering Institute, New York, New York.
authors.forename: Vladimir V
authors.initials: VV
authors.lastname: Didenko
authors.forename: Candace L
authors.initials: CL
authors.lastname: Minchew
authors.forename: Stewart
authors.initials: S
authors.lastname: Shuman
authors.forename: David S
authors.initials: DS
authors.lastname: Baskin