title: Importance of collection tube during clinical studies of oseltamivir.
abstract: Ex vivo conversion of the anti-influenza drug oseltamivir to its active metabolite can be inhibited by the esterase inhibitor dichlorvos or by using commercial fluoride-oxalate tubes. Oseltamivir and its active metabolite remain intact in plasma samples during a proposed virus heat inactivation step: incubation at 60 degrees C for 45 min.
authors.affiliation: Wellcome Trust-Mahidol University-Oxford Tropical Medicine Research Programme, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand. niklas@tropmedres.ac
authors.forename: Niklas
authors.initials: N
authors.lastname: Lindegardh
authors.forename: Geraint R
authors.initials: GR
authors.lastname: Davies
authors.forename: Tran Tinh
authors.initials: TT
authors.lastname: Hien
authors.forename: Jeremy
authors.initials: J
authors.lastname: Farrar
authors.forename: Pratap
authors.initials: P
authors.lastname: Singhasivanon
authors.forename: Nicholas P J
authors.initials: NP
authors.lastname: Day
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: White
mesh_terms: D000998:Antiviral Agents / Q000097:blood*; D001800:Blood Specimen Collection / Q000379:methods*; D004355:Drug Stability; D006801:Humans; D053139:Oseltamivir / Q000097:blood*; D013696:Temperature
chemical_list: D000998:Antiviral Agents; D053139:Oseltamivir