Genetics of polycystic ovarian syndrome.
Polycystic ovarian syndrome is a complex disorder with multiple factors affecting its etiology. Elucidation of specific genes and mode of inheritance remains a significant challenge. Linkage and association studies have resulted in over 50 candidate genes as a source of heritable predisposition; however, small sample sizes and failure to reproduce results have hindered efforts. In addition, low fecundity, lack of a male phenotype, and variation of diagnostic criteria represent unique challenges to discovery of polycystic ovarian syndrome genes. A concerted effort will be necessary to conclusively rule in or rule out candidate genes.
Nam Menke
Marie
M
Virginia Commonwealth University Health System, Richmond, Virginia, USA. mnam@mcvh-vcu.edu
Strauss
Jerome F
JF
D005260:Female; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing / Q000379:methods; D006801:Humans; D040582:Inheritance Patterns / Q000235:genetics*; D011085:Polycystic Ovary Syndrome / Q000235:genetics*; D035781:Siblings