title: Engineering resistance to geminiviruses--review and perspectives.
abstract: Following the conceptual development of virus resistance strategies ranging from coat protein-mediated interference of virus propagation to RNA-mediated virus gene silencing, much progress has been achieved to protect plants against RNA and DNA virus infections. Geminiviruses are a major threat to world agriculture, and breeding resistant crops against these DNA viruses is one of the major challenges faced by plant virologists and biotechnologists. In this article, we review the most recent transgene-based approaches that have been developed to achieve durable geminivirus resistance. Although most of the strategies have been tested in model plant systems, they are ready to be adopted for the protection of crop plants. Furthermore, a better understanding of geminivirus gene and protein functions, as well as the native immune system which protects plants against viruses, will allow us to develop novel tools to expand our current capacity to stabilize crop production in geminivirus epidemic zones.
authors.affiliation: Institute of Plant Sciences, ETH Zurich, Universitätstrasse 2, 8092 Zurich, Switzerland.
authors.forename: Hervé
authors.initials: H
authors.lastname: Vanderschuren
authors.forename: Martin
authors.initials: M
authors.lastname: Stupak
authors.forename: Johannes
authors.initials: J
authors.lastname: Fütterer
authors.forename: Wilhelm
authors.initials: W
authors.lastname: Gruissem
authors.forename: Peng
authors.initials: P
authors.lastname: Zhang
mesh_terms: D017791:Geminiviridae / Q000235:genetics / Q000502:physiology*; D018506:Gene Expression Regulation, Plant; D010935:Plant Diseases / Q000235:genetics / Q000821:virology; D010940:Plant Proteins / Q000235:genetics; D010944:Plants / Q000235:genetics* / Q000821:virology*; D030821:Plants, Genetically Modified; D011401:Promoter Regions, Genetic; D034622:RNA Interference; D014764:Viral Proteins / Q000235:genetics
chemical_list: D010940:Plant Proteins; D014764:Viral Proteins