A highly efficient and general method for the ring-opening of aziridines with various nucleophiles in DMSO.
Ring-opening of aziridines with various nucleophiles (such as amines, thiols, and silylated nucleophiles) in DMSO under mild conditions without any catalyst afforded the corresponding products in good to excellent yields.
Wu
Jie
J
Department of Chemistry, Fudan University, 220 Handan Road, Shanghai, 200433, China. jie_wu@fudan.edu.cn
Sun
Xiaoyu
X
Sun
Wei
W
D001388:Aziridines / Q000737:chemistry*; D004121:Dimethyl Sulfoxide / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism
D001388:Aziridines; D004121:Dimethyl Sulfoxide