Usefulness of serum concentration measurement for acute pentobarbital intoxication in patients.
Toxicokinetic parameters were analyzed in 25 patients who were acutely intoxicated with pentobarbital. The serum pentobarbital concentrations were at hypnotic / therapeutic levels (1- 10 microg/mL) in 11 patients, at toxic levels (10-24 microg/mL) in 10 patients, and at lethal levels (>24 microg/mL) in 4 patients. One fatal case was encountered with a serum pentobarbital concentration of 37.27 microg/ mL. The relationships between serum pentobarbital concentrations and the drug, the induced toxic symptoms, such as respiratory / cardiac depression and hypotension, were in good correlation. The therapy of direct hemoperfusion carried out for many pentobarbital-intoxicated patients was highly effective.
Koyama
Kazuhiro
K
National Cancer Center Hospital, East Pharmacy Divison.
Suzuki
Ryoh
R
Yoshida
Takemi
T
Kikuno
Takaaki
T
D000208:Acute Disease; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D005260:Female; D006464:Hemoperfusion; D006801:Humans; D008297:Male; D008875:Middle Aged; D010424:Pentobarbital / Q000097:blood* / Q000506:poisoning*; D012119:Respiration; D012189:Retrospective Studies; D012720:Severity of Illness Index; D013599:Systole
D015415:Biomarkers; D010424:Pentobarbital