Susceptibilities of methicillin-resistant Staphylococcus aureus isolates to seven biocides.
Minimum bactericidal concentrations (MBCs) of seven biocides for 42 methicillin-resistant Staphylococcus aureus (MRSA) isolates at 5, 30, or 180 min, for hand scrubs or soaks, isolated in 2003 in Japan were determined. The MBC values of glutaraldehyde, povidone iodine, and ethanol were lower than the user concentrations in all exposure times. However, at 5 min exposure of sodium hypochlorite, benzalkonium chloride, alkyldiaminoethylglycine hydrochloride, and chlorhexidine digluconate some strains showed higher MBC values than the user concentrations. These results indicated the possibility that MRSA survived under proper user concentration conditions and exposure time.
Narui
Koji
K
Department of Microbiology, School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.
Takano
Mitsuo
M
Noguchi
Norihisa
N
Sasatsu
Masanori
M
D001548:Benzalkonium Compounds / Q000494:pharmacology; D002710:Chlorhexidine / Q000031:analogs & derivatives / Q000494:pharmacology; D004202:Disinfectants / Q000494:pharmacology*; D000431:Ethanol / Q000494:pharmacology; D005260:Female; D005976:Glutaral / Q000494:pharmacology; D006225:Hand / Q000382:microbiology; D006235:Hand Disinfection; D006801:Humans; D008297:Male; D016106:Methicillin Resistance; D008826:Microbial Sensitivity Tests / Q000379:methods; D009092:Mucous Membrane / Q000382:microbiology; D010802:Phylogeny; D011206:Povidone-Iodine / Q000494:pharmacology; D012973:Sodium Hypochlorite / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D013997:Time Factors; D014556:Urine / Q000382:microbiology; D014947:Wounds and Injuries / Q000382:microbiology
D001548:Benzalkonium Compounds; D004202:Disinfectants; D000431:Ethanol; D011206:Povidone-Iodine; D012973:Sodium Hypochlorite; C010882:chlorhexidine gluconate; D002710:Chlorhexidine; D005976:Glutaral