[Changes of serum cardiotrophin I and cystatin C in preeclampsia and clinical significance thereof].
OBJECTIVE
To investigate the changes and of serum cardiotrophin I (cTN I) and cystatin C in preeclampsia clinical significance thereof.


METHODS
Peripheral blood samples were collected from 40 women with preeclampsia, aged 29 (18 - 39), with the medium gestational age of 35 weeks, and 40 age- and gestational age-matched controls. Serum cTN I and cystatin C were determined with ELISA and serum levels of creatinine kinase, creatinine, and uric acid were assayed by automatic biochemical analyzer. Comparison was made between the 2 groups.


RESULTS
The serum cTn I of the preeclampsia group was 0.59 microg/L +/- 0.42 microg/L, significantly higher than that of the control group (0.09 microg/L +/- 0.22 microg/L P < 0.001), and the serum cystatin C of the preeclampsia group was 1.64 mg/L +/- 0.47 mg/L, significantly higher than that of the control group (1.08 mg/L +/- 0.19 mg/L, P < 0.001). And the serum cardiotrophin I and cystatin C concentrations of the patients with severe preeclampsia were 0.66 microg/L +/- 0.40 microg/L and 1.72 mg/L +/- 0.46 mg/L respectively, both significantly higher than those of the patients with mild preeclampsia (0.17 microg/L +/- 0.26 microg/L and 1.21 mg/L +/- 0.37 mg/L respectively, P < 0.001 and 0.05 respectively).


CONCLUSIONS
Serum cTn I and cystatin C levels are elevated in preeclampsia and the elevation is associated with the severity of preeclampsia, suggesting that serum concentrations of cTn I and cystatin C are useful markers in the early diagnosis of cardiac and renal injury in patients of preeclampsia.
Yang
Xiao-fu
XF
Women's Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China.
Lu
Dong-hong
DH
Wang
Zheng-ping
ZP
He
Jing
J
Wang
Han-zhi
HZ
Dong
Min-yue
MY
D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D016022:Case-Control Studies; D003401:Creatine / Q000097:blood; D003402:Creatine Kinase / Q000097:blood; D055316:Cystatin C; D015891:Cystatins / Q000097:blood*; D005260:Female; D006801:Humans; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy; D011263:Pregnancy Trimester, Third / Q000097:blood; D019210:Troponin I / Q000097:blood*; D014527:Uric Acid / Q000097:blood
C525030:CST3 protein, human; D055316:Cystatin C; D015891:Cystatins; D019210:Troponin I; D014527:Uric Acid; D003402:Creatine Kinase; D003401:Creatine