Management of the BRCA mutation carrier or high-risk patient.
Women who are at high risk of breast cancer are eligible for several risk management strategies including intensified surveillance, chemoprevention, and prophylactic surgery. This article reviews and summarizes the risk factors associated with breast cancer, the different risk calculation models available, and risk management strategies.
Bordeleau
Louise J
LJ
Department of Medical Oncology, University of Toronto, Toronto, Ontario, Canada.
Lipa
Joan E
JE
Neligan
Peter C
PC
D001943:Breast Neoplasms / Q000235:genetics* / Q000517:prevention & control*; D018890:Chemoprevention; D005260:Female; D019398:Genes, BRCA1; D024522:Genes, BRCA2; D020022:Genetic Predisposition to Disease; D006801:Humans; D016462:Mammaplasty; D008327:Mammography; D008408:Mastectomy / Q000379:methods; D009154:Mutation; D010052:Ovariectomy; D010808:Physical Examination; D018570:Risk Assessment