Transient gestational diabetes insipidus diagnosed in successive pregnancies: review of pathophysiology, diagnosis, treatment, and management of delivery.
Gestational diabetes insipidus (GDI) is a rare disorder characterised by polyuria, polydypsia, and excessive thirst usually manifesting in the third trimester of pregnancy. The etiology is thought to depend on excessive vasopressinase activity, a placental enzyme that degrades arginine-vasopressin (AVP), but not 1-deamino-8-D: -arginine vasopressin (dDAVP), which is a synthetic form. This is a transient syndrome and may be associated with acute fatty liver of pregnancy and preeclampsia. The use of dDAVP in symptomatic cases has been proven as a safe method for both the mother and the fetus during the pregnancy. We report a case of recurrent gestational diabetes insipidus in successive pregnancies, which responded to dDAVP and subsided after delivery.
Kalelioglu
Ibrahim
I
Istanbul Faculty of Medicine, Gynecology and Obstetrics, Istanbul University, Istanbul 34390, Turkey.
Kubat Uzum
Ayse
A
Yildirim
Alkan
A
Ozkan
Tulay
T
Gungor
Funda
F
Has
Recep
R
D000328:Adult; D017604:Cesarean Section, Repeat; D003894:Deamino Arginine Vasopressin / Q000627:therapeutic use; D003919:Diabetes Insipidus / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology; D016640:Diabetes, Gestational / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D011247:Pregnancy
D003894:Deamino Arginine Vasopressin