title: Leucine-rich repeat kinase 2 G2385R variant is a risk factor for Parkinson disease in Asian population.
abstract: To assess the effect of genetic factors on sporadic Parkinson disease, we performed a case-control study of a variant (G2385R) in Leucine-Rich Repeat kinase 2 among the Japanese population. The G2385R (c.7153G>A) variant was reported as a risk factor for sporadic Parkinson disease in the Chinese population from Taiwan and Singapore. Genotyping was conducted in 448 Parkinson disease patients and 457 healthy controls. The frequency of A allele in Parkinson disease was significantly higher than in the control (P=1.24x10(-4), odds ratio 2.63, 95% confidence interval 1.56-4.35). Our results suggest that the G2385R variant is a risk factor for sporadic Parkinson disease in the Asian population.
authors.affiliation: Research Institute for Diseases of Old Age, Department of Neurology, Juntendo University School of Medicine, Bunkyo-ku, Tokyo, and Department of Neurology, Kagawa Prefectural Central Hospital, Takamatsu, Japan.
authors.forename: Manabu
authors.initials: M
authors.lastname: Funayama
authors.forename: Yuanzhe
authors.initials: Y
authors.lastname: Li
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Tomiyama
authors.forename: Hiroyo
authors.initials: H
authors.lastname: Yoshino
authors.forename: Yoko
authors.initials: Y
authors.lastname: Imamichi
authors.forename: Mitsutoshi
authors.initials: M
authors.lastname: Yamamoto
authors.forename: Miho
authors.initials: M
authors.lastname: Murata
authors.forename: Tatsushi
authors.initials: T
authors.lastname: Toda
authors.forename: Yoshikuni
authors.initials: Y
authors.lastname: Mizuno
authors.forename: Nobutaka
authors.initials: N
authors.lastname: Hattori
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001208:Asia / Q000208:ethnology; D001921:Brain / Q000201:enzymology / Q000503:physiopathology; D001923:Brain Chemistry / Q000235:genetics*; D015331:Cohort Studies; D004252:DNA Mutational Analysis; D005260:Female; D005787:Gene Frequency; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005820:Genetic Testing; D005838:Genotype; D006801:Humans; D007564:Japan / Q000208:ethnology; D000071158:Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; D008297:Male; D008875:Middle Aged; D009154:Mutation / Q000235:genetics; D010300:Parkinson Disease / Q000201:enzymology* / Q000208:ethnology / Q000235:genetics*; D017346:Protein Serine-Threonine Kinases / Q000235:genetics*
chemical_list: D005819:Genetic Markers; C495280:LRRK2 protein, human; D000071158:Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; D017346:Protein Serine-Threonine Kinases