Caveolin-1 and liver regeneration: role in proliferation and lipogenesis.
Caveolin-1 is an essential component of caveolae, which form 50-100 nm cell surface plasma membrane invaginations. Caveolin-1 has been previously implicated in the regulation of cellular proliferation and lipogenesis. Current data now suggest that caveolin-1 plays an essential role in the regulation of liver regeneration and that it is implicated in the regulation of triglyceride accumulation, which is an essential process that plays a critical role in the regulation of liver regeneration. These findings are consistent with the importance of a lipogenesis program in the regulation of liver regeneration.
Frank
Philippe G
PG
Department of Cancer Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA. Philippe.Frank@jefferson.edu
Lisanti
Michael P
MP
D000818:Animals; D051242:Caveolin 1 / Q000502:physiology*; D049109:Cell Proliferation; D006801:Humans; D050155:Lipogenesis / Q000502:physiology*; D008099:Liver / Q000166:cytology* / Q000378:metabolism / Q000502:physiology; D008115:Liver Regeneration / Q000502:physiology*; D014280:Triglycerides / Q000378:metabolism / Q000502:physiology
D051242:Caveolin 1; D014280:Triglycerides