Cardiovascular disease in diabetic nephropathy patients: cell adhesion molecules as potential markers?
Cardiovascular disease is a major complication of diabetes mellitus, especially for patients with diabetic nephropathy. The underlying factor or pathogenic mechanism that links diabetic nephropathy with cardiovascular disease is not known. The endothelial cell adhesion molecules, intercellular adhesion molecule-1 or vascular cell adhesion molecule-1, play a crucial role in the initiation of atherosclerosis. Levels of both cell adhesion molecules are raised by the diabetic and kidney disease states. This review focuses on these important cell adhesion molecules and their role in the pathogenesis of cardiovascular disease in diabetes and diabetic nephropathy.
Wu
Ted
T
The Heart Research Institute, Camperdown, NSW, Australia.
McGrath
Kristine C Y
KC
Death
Alison K
AK
D000419:Albuminuria / Q000097:blood* / Q000150:complications / Q000188:drug therapy; D050197:Atherosclerosis / Q000097:blood; D015415:Biomarkers / Q000097:blood; D002318:Cardiovascular Diseases / Q000097:blood* / Q000209:etiology / Q000517:prevention & control; D015815:Cell Adhesion Molecules / Q000097:blood*; D003928:Diabetic Nephropathies / Q000097:blood* / Q000150:complications / Q000188:drug therapy; D006801:Humans; D007249:Inflammation / Q000097:blood; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood; D012307:Risk Factors; D012720:Severity of Illness Index; D016896:Treatment Outcome; D019010:Vascular Cell Adhesion Molecule-1 / Q000097:blood
D015415:Biomarkers; D015815:Cell Adhesion Molecules; D019010:Vascular Cell Adhesion Molecule-1; D018799:Intercellular Adhesion Molecule-1