title: Age- and sex-dependent effects of long-term zinc supplementation on essential trace element status and lipid metabolism in European subjects: the Zenith Study.
abstract: Given the key role of Zn in many physiological functions, optimal Zn status could be a predictive parameter of successful ageing. However, the benefit of Zn supplementation is still a matter of debate since Zn supplementation has been reported to be associated with the alteration of Cu status and lipid metabolism. As part of the Zenith Project, the present study aimed to investigate, in free-living healthy European middle-aged and older subjects, the effect of Zn supplementation on the biochemical status of Zn, Fe and Cu and on lipid profile. Volunteers aged 55-70 (n 188) and 70-85 (n 199) years old participated in a double-blinded, randomised study and received a daily placebo, or Zn as 15 or 30 mg for 6 months. Zn supplementation did not significantly modify erythrocyte Zn levels or erythrocyte Cu,Zn-superoxide dismutase activity. But Zn supplementation at 15 or 30 mg/d for 6 months increased significantly serum Zn levels and Zn urinary excretion with no major adverse effects on Fe and Cu status or on lipid metabolism. However, Zn supplementation at 30 mg/d showed some age- and sex-dependent alterations in Fe status or lipid profile. Therefore, with respect to the key role of an optimal Zn status in successful ageing, Zn supplementation at 15 mg/d, when necessary, could be safely proposed regarding lipids and the risk of interaction with Fe and Cu.
authors.affiliation: Laboratoire de Nurtition, Vieillissement et Maladies Cardiovasculaires (NVMC), La Tronche Cedex, France. Isabelle.Hininger@ujf-grenoble.fr
authors.forename: Isabelle
authors.initials: I
authors.lastname: Hininger-Favier
authors.forename: Maud
authors.initials: M
authors.lastname: Andriollo-Sanchez
authors.forename: Josiane
authors.initials: J
authors.lastname: Arnaud
authors.forename: Nathalie
authors.initials: N
authors.lastname: Meunier
authors.forename: Séverine
authors.initials: S
authors.lastname: Bord
authors.forename: Ciaren
authors.initials: C
authors.lastname: Graham
authors.forename: Angela
authors.initials: A
authors.lastname: Polito
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Maiani
authors.forename: Jacqueline M
authors.initials: JM
authors.lastname: O'Connor
authors.forename: Charles
authors.initials: C
authors.lastname: Coudray
authors.forename: Anne-Marie
authors.initials: AM
authors.lastname: Roussel
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D015992:Body Mass Index; D003300:Copper / Q000008:administration & dosage / Q000097:blood; D019587:Dietary Supplements; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D002149:Energy Intake / Q000187:drug effects; D005260:Female; D006801:Humans; D050356:Lipid Metabolism / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D012737:Sex Factors; D014131:Trace Elements / Q000097:blood*; D015032:Zinc / Q000493:pharmacokinetics / Q000494:pharmacology*
chemical_list: D014131:Trace Elements; D003300:Copper; D015032:Zinc