Fcgamma receptors are crucial for the expression of acquired resistance to virulent Salmonella enterica serovar Typhimurium in vivo but are not required for the induction of humoral or T-cell-mediated immunity.
Antibodies play an important role in immunity to Salmonella enterica. Here we evaluated the requirement for Fcgamma receptors in host resistance to S. enterica using an in vivo model of systemic infection. We show that mice lacking FcgammaRI, II and III can control and clear a primary infection with S. enterica micro-organisms of low virulence, but are impaired in the expression of vaccine-induced acquired immunity to oral challenge with virulent bacteria. We also show that, in vivo, FcgammaRI, II, III(-/-) mice were able to mount efficient T-helper 1 type T-cell responses and antibody responses specific for S. enterica. The work indicates that targeting S. enterica to FcgammaR is needed for the expression of vaccine-induced acquired immunity, but is not essential for the engenderment of T- and B-cell immunity to the bacterium in vivo.
Menager
Nathalie
N
Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.
Foster
Gemma
G
Ugrinovic
Sanja
S
Uppington
Hazel
H
Verbeek
Sjef
S
Mastroeni
Pietro
P
D000818:Animals; D000907:Antibodies, Bacterial / Q000096:biosynthesis; D005260:Female; D007111:Immunity, Cellular; D008099:Liver / Q000276:immunology / Q000382:microbiology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D017452:Receptors, IgG / Q000276:immunology*; D012480:Salmonella Infections / Q000276:immunology* / Q000382:microbiology / Q000517:prevention & control; D022562:Salmonella Vaccines / Q000276:immunology*; D012486:Salmonella typhimurium / Q000254:growth & development* / Q000276:immunology / Q000472:pathogenicity; D013154:Spleen / Q000276:immunology / Q000382:microbiology; D016176:T-Lymphocyte Subsets / Q000276:immunology; D014774:Virulence
D000907:Antibodies, Bacterial; D017452:Receptors, IgG; D022562:Salmonella Vaccines