title: Changes in cortical and pallidal oscillatory activity during the execution of a sensory trick in patients with cervical dystonia.
abstract: We examined the effects of a sensory trick (SeT) on cortical EEG and globus pallidus (GP) local field potentials in four cervical dystonia patients, two of whom had an effective SeT and two who did not. The application of an effective SeT was associated with bilateral desynchronization in the 6-8 Hz and beta bands in the GP and sensorimotor cortical regions. In contrast, mimicking an SeT led to a worsening of dystonia, which was associated with desynchronization of the beta band and synchronization in the 4-6 Hz range. These preliminary findings suggest a role for 4-8 Hz frequency synchronization in the pathophysiology of dystonia.
authors.affiliation: Department of Physiology, Med Sci Bldg 3302, 1 King's College Circle, University of Toronto, Toronto, Ontario, Canada M5S 1A8.
authors.forename: Joyce K H
authors.initials: JK
authors.lastname: Tang
authors.forename: Neil
authors.initials: N
authors.lastname: Mahant
authors.forename: Danny
authors.initials: D
authors.lastname: Cunic
authors.forename: Robert
authors.initials: R
authors.lastname: Chen
authors.forename: Elena
authors.initials: E
authors.lastname: Moro
authors.forename: Anthony E
authors.initials: AE
authors.lastname: Lang
authors.forename: Andres M
authors.initials: AM
authors.lastname: Lozano
authors.forename: William D
authors.initials: WD
authors.lastname: Hutchison
authors.forename: Jonathan O
authors.initials: JO
authors.lastname: Dostrovsky
mesh_terms: D000328:Adult; D000368:Aged; D004569:Electroencephalography / Q000379:methods; D004576:Electromyography / Q000379:methods; D005260:Female; D005917:Globus Pallidus / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011340:Problem Solving / Q000502:physiology*; D011597:Psychomotor Performance / Q000502:physiology; D013003:Somatosensory Cortex / Q000503:physiopathology*; D014103:Torticollis / Q000473:pathology* / Q000503:physiopathology*