title: Safety of percutaneous injection of bovine dermal crosslinked collagen for glottic insufficiency.
abstract: OBJECTIVE
  Our aim was to review the safety of percutaneous injection laryngoplasty using bovine crosslinked collagen, focusing specifically on two often-stated concerns: injecting patients who are taking the anticoagulant medication warfarin, and injecting patients without prior skin hypersensitivity testing.
  
  
  METHODS
  Retrospective chart review of injection laryngoplasty performed between 1997 and 2006 at the University of California, Los Angeles.
  
  
  RESULTS
  The study group consisted of 895 patients who underwent 1290 injection laryngoplasty procedures. No bleeding complications were noted in 59 patients taking warfarin. No allergic complications were reported in 845 patients who did not undergo skin hypersensitivity testing before injection laryngoplasty.
  
  
  CONCLUSIONS
  Percutaneous bovine crosslinked collagen injection laryngoplasty is safe in patients taking warfarin. Skin testing for hypersensitivity does not appear to be necessary before injection.
  
  
  CONCLUSIONS
  Patients on warfarin are candidates for injection laryngoplasty without the need to discontinue the medication. Eliminating skin hypersensitivity testing before percutaneous bovine crosslinked collagen injection laryngoplasty allows for a prompt treatment of glottic insufficiency.
authors.affiliation: Division of Otolaryngology/Head and Neck Surgery, Department of Surgery, University of California, Los Angeles, CA, USA.
authors.forename: Quang
authors.initials: Q
authors.lastname: Luu
authors.forename: Veling
authors.initials: V
authors.lastname: Tsai
authors.forename: Venkat
authors.initials: V
authors.lastname: Mangunta
authors.forename: Gerald S
authors.initials: GS
authors.lastname: Berke
authors.forename: Dinesh K
authors.initials: DK
authors.lastname: Chhetri
mesh_terms: D000368:Aged; D000818:Animals; D000925:Anticoagulants / Q000627:therapeutic use; D001672:Biocompatible Materials / Q000627:therapeutic use*; D002417:Cattle; D003094:Collagen / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D005931:Glottis / Q000601:surgery*; D006801:Humans; D006967:Hypersensitivity / Q000175:diagnosis; D007271:Injections, Intradermal; D007818:Laryngeal Diseases / Q000601:surgery*; D008297:Male; D011183:Postoperative Complications / Q000517:prevention & control; D019106:Postoperative Hemorrhage / Q000517:prevention & control; D019736:Prostheses and Implants; D012189:Retrospective Studies; D012449:Safety; D014826:Vocal Cord Paralysis / Q000601:surgery; D014832:Voice Disorders / Q000601:surgery; D014859:Warfarin / Q000627:therapeutic use
chemical_list: D000925:Anticoagulants; D001672:Biocompatible Materials; C048470:glutaraldehyde-cross-linked collagen; D014859:Warfarin; D003094:Collagen