Gamma interferon suppresses erythropoiesis via interleukin-15.
Impaired erythropoiesis causes anemia during genetic disorders, chronic disease, and infection. In studies of the underlying mechanisms researchers have increasingly focused on gamma interferon (IFN-gamma). Here, we identified a previously unrecognized role for interleukin-15 (IL-15) in red blood cell homeostasis and demonstrated that IFN-gamma and signal transducer and activator of transcription protein 1-dependent pathways up-regulate expression of IL-15 in vivo. These findings identified new therapeutic targets for anemia.
Mullarky
Isis K
IK
Trudeau Institute, Saranac Lake, New York, USA. mullarky@vt.edu
Szaba
Frank M
FM
Kummer
Lawrence W
LW
Wilhelm
Lindsey B
LB
Parent
Michelle A
MA
Johnson
Lawrence L
LL
Smiley
Stephen T
ST
D000740:Anemia / Q000469:parasitology / Q000503:physiopathology; D000818:Animals; D001854:Bone Marrow Cells; D002478:Cells, Cultured; D004920:Erythropoiesis / Q000187:drug effects*; D007371:Interferon-gamma / Q000494:pharmacology*; D019409:Interleukin-15 / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL; D050794:STAT1 Transcription Factor / Q000378:metabolism; D014122:Toxoplasma / Q000472:pathogenicity*; D014124:Toxoplasmosis, Animal / Q000469:parasitology / Q000503:physiopathology*; D015854:Up-Regulation
D019409:Interleukin-15; D050794:STAT1 Transcription Factor; D007371:Interferon-gamma