title: Mitochondrial dysfunction in Parkinson's disease.
abstract: Parkinson's disease (PD) is one of the most common neurodegenerative disorders characterized by resting tremor, rigidity, and bradykinesia. The primary cause of PD is still unknown, but oxidative stress and mitochondrial dysfunction have been implicated as important contributors to neuronal death in substantia nigra (SN) of PD. Considering neurons as post-mitotic cells, neurons could have error-avoiding mechanism against oxidative DNA damage. Indeed, several DNA repairing enzymes such as MTH1, OGG1, and MUTYH express in human brain. All the three enzymes up-regulated in the SN of PD patients, suggesting these three enzymes cooperate in mitochondrial DNA repairing in PD brain.
authors.affiliation: Department of Neurology, Juntendo University School of Medicine, 2-1-1 Hongo, Tokyo 113-8421, Japan.
authors.forename: Jiro
authors.initials: J
authors.lastname: Fukae
authors.forename: Yoshikuni
authors.initials: Y
authors.lastname: Mizuno
authors.forename: Nobutaka
authors.initials: N
authors.lastname: Hattori
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000502:physiology; D045647:DNA Glycosylases / Q000235:genetics; D045643:DNA Repair Enzymes / Q000235:genetics; D004272:DNA, Mitochondrial / Q000235:genetics*; D006801:Humans; D020267:MPTP Poisoning / Q000503:physiopathology; D008928:Mitochondria / Q000473:pathology / Q000502:physiology*; D018384:Oxidative Stress / Q000502:physiology; D010300:Parkinson Disease / Q000235:genetics / Q000503:physiopathology*; D010744:Phosphoric Monoester Hydrolases / Q000235:genetics
chemical_list: D000975:Antioxidants; D004272:DNA, Mitochondrial; D010744:Phosphoric Monoester Hydrolases; D045647:DNA Glycosylases; C061738:mutY adenine glycosylase; C479058:oxoguanine glycosylase 1, human; C078207:8-oxodGTPase; D045643:DNA Repair Enzymes