Proposals for standardized protocols for cytogenetic analyses of acute leukemias, chronic lymphocytic leukemia, chronic myeloid leukemia, chronic myeloproliferative disorders, and myelodysplastic syndromes.
The impact of cytogenetic characterization based on chromosome banding analyses and fluorescence in situ hybridization on clinical decision making has increased dramatically during recent years. Therefore, laboratory techniques have to be optimized to provide reliable results for optimal patient care. In addition, quick and correct results save time and money by preventing unnecessary additional diagnostics and suboptimal treatment approaches. It was our aim to present proposals for standardized protocols to improve the diagnosis, and hence the treatment outcome, of hematologic malignancies.
Haferlach
Claudia
C
MLL Munich Leukemia Laboratory, Munich, Germany. claudia.haferlach@mll-online.com
Rieder
Harald
H
Lillington
Debra M
DM
Dastugue
Nicole
N
Hagemeijer
Anne
A
Harbott
Jochen
J
Stilgenbauer
Stephan
S
Knuutila
Sakari
S
Johansson
Bertil
B
Fonatsch
Christa
C
D000208:Acute Disease; D002869:Chromosome Aberrations; D020732:Cytogenetic Analysis / Q000379:methods*; D003937:Diagnosis, Differential; D006801:Humans; D007621:Karyotyping; D007938:Leukemia / Q000175:diagnosis / Q000235:genetics*; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000175:diagnosis / Q000235:genetics*; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000175:diagnosis / Q000235:genetics*; D009190:Myelodysplastic Syndromes / Q000175:diagnosis / Q000235:genetics*; D009196:Myeloproliferative Disorders / Q000175:diagnosis / Q000235:genetics*