title: Risk factors of local relapse in breast cancer: the importance of age.
abstract: OBJECTIVE
  The objective of the present analysis is to know what risk factors affect local relapse in breast cancer.
  
  
  METHODS
  A total of 1165 patients diagnosed with early breast cancer were included. Boost dose was modulated in the presence of risk factors. Patients with one risk factor received a boost of 10 Gy, while 20 Gy was administered in those with two risk factors.
  
  
  RESULTS
  Median follow-up was of 60 months. Mean age of patients was 56.7+/-10.8 years. Local risk factors were present in 82.8% of patients. The probability of remaining free of local recurrence at 5 and 10 years is 97.7% (CI 95%: 96.7-98.7) and 94.5% (CI 95%: 92.1-96.9). Only age showed an impact in local relapse on multivariate analysis. Patients 40 years or younger had a relative risk of local relapse of 5.27 and patients 41-50 of 3.7 with respect to patients older than 50 years.
  
  
  CONCLUSIONS
  Patients 40 years or younger have a higher risk of local failure than older patients. Other risk factors such as tumour size, intraductal carcinoma or margin status could be masked by an increase of radiation dose.
authors.affiliation: Institut d'Oncologia Radioteràpica, L'Institut Municipal d'Assistència Sanitària (IMAS), Universitat Pompeu Fabra, Hospital de l'Esperança, C/Sant Josep de la Montanya 12, 08024 Barcelona, Spain. malgara@imas.imim.es
authors.forename: M
authors.initials: M
authors.lastname: Algara López
authors.forename: X
authors.initials: X
authors.lastname: Sanz Latiesas
authors.forename: P
authors.initials: P
authors.lastname: Foro Arnalot
authors.forename: M
authors.initials: M
authors.lastname: Lacruz Bassols
authors.forename: A
authors.initials: A
authors.lastname: Reig Castillejo
authors.forename: J
authors.initials: J
authors.lastname: Quera Jordana
authors.forename: I
authors.initials: I
authors.lastname: Membrive Conejo
authors.forename: J
authors.initials: J
authors.lastname: Lozano Galán
authors.forename: N
authors.initials: N
authors.lastname: Rodríguez de Dios
mesh_terms: D000230:Adenocarcinoma / Q000453:epidemiology* / Q000532:radiotherapy*; D000367:Age Factors; D001943:Breast Neoplasms / Q000453:epidemiology* / Q000532:radiotherapy*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology*; D012307:Risk Factors