Human neuroblasts migrate to the olfactory bulb via a lateral ventricular extension.
The rostral migratory stream (RMS) is the main pathway by which newly born subventricular zone cells reach the olfactory bulb (OB) in rodents. However, the RMS in the adult human brain has been elusive. We demonstrate the presence of a human RMS, which is unexpectedly organized around a lateral ventricular extension reaching the OB, and illustrate the neuroblasts in it. The RMS ensheathing the lateral olfactory ventricular extension, as seen by magnetic resonance imaging, cell-specific markers, and electron microscopy, contains progenitor cells with migratory characteristics and cells that incorporate 5-bromo-2'-deoxyuridine and become mature neurons in the OB.
Curtis
Maurice A
MA
Department of Anatomy with Radiology, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand.
Kam
Monica
M
Nannmark
Ulf
U
Anderson
Michelle F
MF
Axell
Mathilda Zetterstrom
MZ
Wikkelso
Carsten
C
Holtås
Stig
S
van Roon-Mom
Willeke M C
WM
Björk-Eriksson
Thomas
T
Nordborg
Claes
C
Frisén
Jonas
J
Dragunow
Michael
M
Faull
Richard L M
RL
Eriksson
Peter S
PS
D017209:Apoptosis; D051792:Basic Helix-Loop-Helix Proteins / Q000235:genetics; D002454:Cell Differentiation; D002465:Cell Movement; D002467:Cell Nucleus / Q000737:chemistry / Q000648:ultrastructure; D048430:Cell Shape; D000089622:Doublecortin Domain Proteins; D004805:Ependyma / Q000166:cytology; D005136:Eye Proteins / Q000235:genetics; D018398:Homeodomain Proteins / Q000235:genetics; D006801:Humans; D020547:Lateral Ventricles / Q000033:anatomy & histology / Q000166:cytology*; D008279:Magnetic Resonance Imaging; D008854:Microscopy, Electron; D008869:Microtubule-Associated Proteins / Q000235:genetics; D009419:Nerve Tissue Proteins / Q000235:genetics; D039842:Neural Cell Adhesion Molecule L1 / Q000032:analysis; D009474:Neurons / Q000737:chemistry / Q000166:cytology / Q000502:physiology* / Q000648:ultrastructure; D009479:Neuropeptides / Q000235:genetics; D009830:Olfactory Bulb / Q000033:anatomy & histology / Q000166:cytology*; D009833:Olfactory Pathways / Q000033:anatomy & histology / Q000166:cytology*; D000076104:Oligodendrocyte Transcription Factor 2; D000071841:PAX6 Transcription Factor; D051761:Paired Box Transcription Factors / Q000235:genetics; D016548:Prosencephalon / Q000033:anatomy & histology / Q000166:cytology*; D012097:Repressor Proteins / Q000235:genetics; D012794:Sialic Acids / Q000032:analysis; D013234:Stem Cells / Q000737:chemistry / Q000166:cytology / Q000502:physiology* / Q000648:ultrastructure; D014404:Tubulin / Q000032:analysis
D051792:Basic Helix-Loop-Helix Proteins; D000089622:Doublecortin Domain Proteins; D005136:Eye Proteins; D018398:Homeodomain Proteins; D008869:Microtubule-Associated Proteins; D009419:Nerve Tissue Proteins; D039842:Neural Cell Adhesion Molecule L1; D009479:Neuropeptides; D000076104:Oligodendrocyte Transcription Factor 2; D000071841:PAX6 Transcription Factor; D051761:Paired Box Transcription Factors; D012097:Repressor Proteins; D012794:Sialic Acids; D014404:Tubulin; C405708:OLIG2 protein, human; C000605730:PAX6 protein, human; C103469:polysialyl neural cell adhesion molecule