title: Flare-up of dermatomyositis along with recurrence of breast cancer.
abstract: Dermatomyositis is an idiopathic inflammatory myopathy with characteristic cutaneous manifestations. The association between dermatomyositis and malignancy is becoming more clearly delineated. A sort of dermatomyositis is thought to be paraneoplastic syndrome and dermatomyositis may follow clinical course of malignancy. We report a 68-year-old woman with dermatomyositis, whose clinical onset of dermatomyositis was apparently concomitant with breast cancer. Dermatomyositis had settled down and oral steroid could be tapered after the resection of breast cancer. Creatine kinase value was elevated before the detection of the first and second recurrence and in the terminal state. At the second recurrence, skin lesions and creatine kinase value had flared up and immediate metastatic check-up revealed the recurrence. Our case shows dermatomyositis, which was thought to be paraneoplastic syndrome, that followed clinical course of malignancy and suggests immediate check-up is needed for early detection of recurrence when dermatomyositis flares up after the resection of the malignancy.
authors.affiliation: Department of Medical Oncology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan. tomo.osako@jfcr.or.jp
authors.forename: Tomo
authors.initials: T
authors.lastname: Osako
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Ito
authors.forename: Akeshi
authors.initials: A
authors.lastname: Morimatsu
authors.forename: Keiichiro
authors.initials: K
authors.lastname: Tada
authors.forename: Naoki
authors.initials: N
authors.lastname: Sakurai
authors.forename: Shunji
authors.initials: S
authors.lastname: Takahashi
authors.forename: Futoshi
authors.initials: F
authors.lastname: Akiyama
authors.forename: Takuji
authors.initials: T
authors.lastname: Iwase
authors.forename: Kiyohiko
authors.initials: K
authors.lastname: Hatake
mesh_terms: D002293:Adenocarcinoma, Scirrhous / Q000175:diagnosis / Q000628:therapy; D000368:Aged; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000628:therapy; D018270:Carcinoma, Ductal, Breast / Q000175:diagnosis* / Q000628:therapy; D003402:Creatine Kinase / Q000097:blood; D003882:Dermatomyositis / Q000175:diagnosis / Q000209:etiology*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary; D008197:Lymph Node Excision; D008207:Lymphatic Metastasis; D008408:Mastectomy; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis* / Q000628:therapy; D010257:Paraneoplastic Syndromes / Q000175:diagnosis / Q000209:etiology*
chemical_list: D003402:Creatine Kinase