title: A case series of alopecia areata in children: impact of personal and family history of stress and autoimmunity.
abstract: BACKGROUND
  The epidemiology of alopecia areata (AA) is well documented in adults but has not been studied adequately in children.
  
  
  OBJECTIVE
  To evaluate the clinical and epidemiological profile of AA in children and assess the significance of thyroid screening.
  
  
  METHODS
  One hundred and fifty-seven children (83 boys, 74 girls, aged 1-16 years) who visited our clinic with a first episode of AA from 1996 to 2000 were retrospectively studied. One hundred children served as clinical controls.
  
  
  RESULTS
  The age of peak incidence of AA was 0-5 years. The youngest child was 1 year old. In the majority of the cases (131/157, 83.4%) the disease was mild or moderate (less than 50% hair loss). In 15 patients (9.5%), AA was preceded by a stressful event. Five patients had a personal history of autoimmune disease (3.2 vs. 5% of the controls, (P = not significant [NS]) while 18 patients had a personal history of atopy (11.4 vs. 18% of the controls, P = NS). Twenty-one patients had a family history of autoimmune disease other than thyroiditis (13.4 vs. 5% of the controls, P = 0.04), while 23 patients had a family history of thyroid disorder (14.6 vs. 3% of the controls, P = 0.006). In eight patients (5%) subclinical hypothyroidism of autoimmune aetiology (Hashimoto's thyroiditis) was revealed at the time of investigation. Six out of the eight patients with Hashimoto's thyroiditis had a family history of thyroid disorder, which was statistically significant when compared to AA patients without thyroiditis (P < 0.001). The severity of AA was associated with early age of onset of the disease (P = 0.02).
  
  
  CONCLUSIONS
  The age of peak incidence of AA in children is 0-5 years. Children with AA have an increased family history of autoimmunity, and, among children with a first episode and short duration of AA (< 6 months), thyroid screening might be restricted in those with a positive family history of thyroid disorder. Thyroid screening should be routinely performed in all children with long-standing AA.
authors.affiliation: First Department of Pediatrics, Athens University Medical School, Aghia Sophia Children's Hospital, 11527 Athens, Greece. kakst@otenet.gr
authors.forename: T
authors.initials: T
authors.lastname: Kakourou
authors.forename: K
authors.initials: K
authors.lastname: Karachristou
authors.forename: G
authors.initials: G
authors.lastname: Chrousos
mesh_terms: D000293:Adolescent; D017668:Age of Onset; D000506:Alopecia Areata / Q000453:epidemiology* / Q000209:etiology / Q000276:immunology; D001327:Autoimmune Diseases / Q000150:complications* / Q000453:epidemiology; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D002648:Child; D002675:Child, Preschool; D005260:Female; D006115:Greece / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D007223:Infant; D016015:Logistic Models; D008297:Male; D012189:Retrospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D013315:Stress, Psychological / Q000150:complications* / Q000453:epidemiology; D013959:Thyroid Diseases / Q000150:complications / Q000453:epidemiology / Q000235:genetics; D013960:Thyroid Function Tests