Efficacy of the de novo-derived antimicrobial peptide WLBU2 against oral bacteria.
The efficacy of a novel synthetic antimicrobial peptide (WLBU2) was evaluated against three oral microorganisms (grown planktonically): Streptococcus gordonii, Fusobacterium nucleatum, and Porphyromonas gingivalis. WLBU2 killed all three species, with F. nucleatum being the most susceptible. WLBU2 also reduced the bacterial burden of S. gordonii and F. nucleatum biofilms.
Novak
Karen F
KF
Center for Oral Health Research, 414 Health Sciences Research Building, University of Kentucky, Lexington, KY 40536-0305, USA. knova2@uky.edu
Diamond
William J
WJ
Kirakodu
Sreenatha
S
Peyyala
Rebecca
R
Anderson
Kimberly W
KW
Montelaro
Ronald C
RC
Mietzner
Timothy A
TA
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D023181:Antimicrobial Cationic Peptides / Q000494:pharmacology*; D018441:Biofilms / Q000187:drug effects; D016967:Fusobacterium nucleatum / Q000187:drug effects*; D006801:Humans; D008826:Microbial Sensitivity Tests; D010455:Peptides / Q000494:pharmacology*; D016966:Porphyromonas gingivalis / Q000187:drug effects*; D013291:Streptococcus / Q000187:drug effects*
D000900:Anti-Bacterial Agents; D023181:Antimicrobial Cationic Peptides; D010455:Peptides; C520840:WLBU2 peptide