Synthesis, antimicrobial activities and cytogenetic studies of newer diazepino quinoline derivatives via Vilsmeier-Haack reaction.
The study of the Vilsmeier-Haack reagent on 4-hydroxyquinaldines resulted in a new versatile intermediate 4-chloro-3-formyl-2-(2-hydroxy-ethene-1-yl)quinolines, which on further treatment with hydrazine hydrate yielded the desired diazepino quinoline derivatives. All the synthesized diazepino quinoline derivatives are screened for their antibacterial and antifungal activities. Cytogenetic analysis of the samples is also reported.
Nandhakumar
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Bio-Chiral Laboratory, Department of Chemistry, Ewha Womans University, 11-1, Daehyun dong, Seodaemun gu, Seoul 120-750, South Korea. rajunandhakumar@yahoo.com
Suresh
T
T
Jude
A L Calistus
AL
Rajesh Kannan
V
V
Mohan
P S
PS
D000328:Adult; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001381:Azepines / Q000138:chemical synthesis*; D001419:Bacteria / Q000187:drug effects; D002478:Cells, Cultured; D002869:Chromosome Aberrations / Q000139:chemically induced*; D020732:Cytogenetic Analysis; D005658:Fungi / Q000187:drug effects; D006801:Humans; D007962:Leukocytes; D008297:Male; D009152:Mutagenicity Tests; D011804:Quinolines / Q000138:chemical synthesis*
D000890:Anti-Infective Agents; D001381:Azepines; D011804:Quinolines; C037219:quinoline