Preparation and antibacterial activity of copper and cobalt complexes of 4-chloro-3-nitrobenzoate with a nitrogen donor ligand.
Copper and cobalt complexes with 4-chloro-3-nitrobenzoate (ClNBz) and the nitrogen ligands 1,3-diaminopropane (1,3-DAP) or o-phenylenediamine (o-PDA), were prepared and characterized. The complexes [Cu(ClNBz)2(1,3-DAP)] (1), [Cu(ClNBz)(o-PDA)]Cl (2), [Co(ClNBz)2(1,3-DAP)] (3) and [Co(ClNBz)2(o-PDA)2] (4) were characterized by FTIR, UV-Visible absorption, elemental analysis and thermal analysis. Complex [Cu(ClNBz)(o-PDA)]Cl (2) shows high antibacterial activity as indicated by its ability to inhibit the growth of Staphylococcus aureus, Enterococcus faecalis.
Kabbani
Ahmad Toufic
AT
Natural Science Division, Lebanese American University, Beirut-Lebanon. akabbani@lau.edu.lb
Hammud
Hassan Hasan
HH
Ghannoum
Amer Mohammed
AM
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D002723:Chlorobenzoates / Q000737:chemistry*; D003035:Cobalt / Q000737:chemistry*; D003300:Copper / Q000737:chemistry*; D008024:Ligands; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D009584:Nitrogen / Q000737:chemistry* / Q000378:metabolism
D000900:Anti-Bacterial Agents; D002723:Chlorobenzoates; D008024:Ligands; C040769:4-chloro-3-nitrobenzoic acid; D003035:Cobalt; D003300:Copper; D009584:Nitrogen