Changes in cortical and pallidal oscillatory activity during the execution of a sensory trick in patients with cervical dystonia.
We examined the effects of a sensory trick (SeT) on cortical EEG and globus pallidus (GP) local field potentials in four cervical dystonia patients, two of whom had an effective SeT and two who did not. The application of an effective SeT was associated with bilateral desynchronization in the 6-8 Hz and beta bands in the GP and sensorimotor cortical regions. In contrast, mimicking an SeT led to a worsening of dystonia, which was associated with desynchronization of the beta band and synchronization in the 4-6 Hz range. These preliminary findings suggest a role for 4-8 Hz frequency synchronization in the pathophysiology of dystonia.
Tang
Joyce K H
JK
Department of Physiology, Med Sci Bldg 3302, 1 King's College Circle, University of Toronto, Toronto, Ontario, Canada M5S 1A8.
Mahant
Neil
N
Cunic
Danny
D
Chen
Robert
R
Moro
Elena
E
Lang
Anthony E
AE
Lozano
Andres M
AM
Hutchison
William D
WD
Dostrovsky
Jonathan O
JO
D000328:Adult; D000368:Aged; D004569:Electroencephalography / Q000379:methods; D004576:Electromyography / Q000379:methods; D005260:Female; D005917:Globus Pallidus / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011340:Problem Solving / Q000502:physiology*; D011597:Psychomotor Performance / Q000502:physiology; D013003:Somatosensory Cortex / Q000503:physiopathology*; D014103:Torticollis / Q000473:pathology* / Q000503:physiopathology*