Phytochemical investigation of Perovskia abrotanoides.
The phytochemical investigation of the n-hexane, the EtOAc, and the n-BuOH soluble fractions of the methanolic extract of the arial parts of Perovskia abrotanoides Karelin furnished ten compounds including the two new tetracyclic diterpenes abrotandiol (7) and abrotanone (8) besides the known cirsimaritin (9), hespiridin (10), rosmarinic acid (11), stigmast-5-en-3beta-ol (12), stigmast-5,22-dien-3beta-ol (13), stigmast-5-en-3beta,7alpha-diol (14), ursolic acid (15) and betulinic acid (16). Compounds 7 and 8 both show a 6,5,6,6 ring skeleton with a trans-1,1-dimethylcyclohexano[e,b]tetrahydrofuran element perpendicular to a benzodihydropyran system. The complete structure elucidation of these compounds has been achieved with NMR techniques.
Khaliq
Simin
S
Department of Pharmaceutical Chemistry, University of Freiburg, Germany.
Volk
Franz-Josef
FJ
Frahm
August Wilhelm
AW
D004224:Diterpenes / Q000737:chemistry; D006801:Humans; D019686:Lamiaceae; D009682:Magnetic Resonance Spectroscopy; D008517:Phytotherapy; D035261:Plant Components, Aerial; D010936:Plant Extracts / Q000737:chemistry*
D004224:Diterpenes; D010936:Plant Extracts