title: Dose selection in stereotactic radiosurgery.
abstract: Selecting optimal doses for radiosurgery requires a thorough consideration of existing dose-response data for radiation injury of brain and surrounding structures and of the doseresponse for the desired endpoint (tumor control, obliteration of a vascular malformation, relief of trigeminal neuralgia, etc.). This paper reviews the radiobiological and physics principles that should be considered in dose selection as well as information from retrospective and prospective clinical investigations of radiosurgery.
authors.affiliation: Department of Radiation Oncology, University of Pittsburgh School of Medicine, Pittsburgh, Pa., USA.
authors.forename: John C
authors.initials: JC
authors.lastname: Flickinger
authors.forename: Douglas
authors.initials: D
authors.lastname: Kondziolka
authors.forename: Ajay
authors.initials: A
authors.lastname: Niranjan
authors.forename: L Dade
authors.initials: LD
authors.lastname: Lunsford
mesh_terms: D001932:Brain Neoplasms / Q000532:radiotherapy / Q000556:secondary / Q000601:surgery*; D005909:Glioblastoma / Q000601:surgery; D006801:Humans; D011832:Radiation Injuries / Q000517:prevention & control; D016634:Radiosurgery / Q000009:adverse effects / Q000379:methods*; D011879:Radiotherapy Dosage; D018570:Risk Assessment; D017211:Treatment Failure