Antifertility activity of the methanolic leaf extract of Cissampelos pareira in female albino mice.
meenakshi Cissampelos pareira Linn. is one of the folk medicinal plants commonly used as antifertility agent in some places of India. The aim of the present study was to evaluate the validity of the antifertility effect of the leaf extract. Cissampelos pareira leaf extract, when administered orally, altered the estrous cycle pattern in female mice, prolonged the length of estrous cycle with significant increase in the duration of diestrus stage and reduced significantly the number of litters in albino mice. The analysis of the principal hormones involved in estrous cycle regulation showed that the plant extract altered gonadotropin release (LH, FSH and prolactin) and estradiol secretion. The results indicated the antifertility effect of Cissampelos pareira leaf extract in female albino mice. The oral LD50 of the extract was found to be 7.3 g/kg in mice.
Ganguly
Mausumi
M
Department of Chemistry, Cotton College, Guwahati 781001, Assam, India. ganguly_mausumi@rediffmail.com
Kr Borthakur
Mridul
M
Devi
Nirada
N
Mahanta
Rita
R
D000818:Animals; D031606:Cissampelos; D003271:Contraceptive Agents, Female / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004958:Estradiol / Q000378:metabolism; D030762:Estrous Cycle / Q000187:drug effects*; D005260:Female; D005298:Fertility / Q000187:drug effects*; D005640:Follicle Stimulating Hormone / Q000378:metabolism; D007194:India; D007928:Lethal Dose 50; D007986:Luteinizing Hormone / Q000187:drug effects / Q000378:metabolism; D008519:Medicine, Traditional; D051379:Mice; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology*; D018515:Plant Leaves; D010946:Plants, Medicinal; D011388:Prolactin / Q000187:drug effects / Q000378:metabolism
D003271:Contraceptive Agents, Female; D010936:Plant Extracts; D004958:Estradiol; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone