title: Prevention and treatment of Alzheimer disease and aging: antioxidants.
abstract: There is considerable evidence showing that oxidative damage is one of the earliest neuronal and pathological changes of Alzheimer disease and many, if not all, of the etiological and pathological causes of the disease are related, directly or indirectly, to free radical production and oxidative damage. Here we summarize the current body of knowledge suggestive that oxidative damage is, if not the key factor, certainly a major factor in Alzheimer disease. As such, therapeutic modalities encompassing antioxidants may be an effective approach to the treatment of neurodegenerative diseases and delay the aging process.
authors.affiliation: Department of Ophthalmology, University of California-San Diego, 9500 Gilman Drive #0946, La Jolla, CA 92093-0946, USA. quliu@ucsd.edu
authors.forename: Quan
authors.initials: Q
authors.lastname: Liu
authors.forename: Fang
authors.initials: F
authors.lastname: Xie
authors.forename: Raj
authors.initials: R
authors.lastname: Rolston
authors.forename: Paula I
authors.initials: PI
authors.lastname: Moreira
authors.forename: Akihiko
authors.initials: A
authors.lastname: Nunomura
authors.forename: Xiongwei
authors.initials: X
authors.lastname: Zhu
authors.forename: Mark A
authors.initials: MA
authors.lastname: Smith
authors.forename: George
authors.initials: G
authors.lastname: Perry
mesh_terms: D000375:Aging / Q000187:drug effects* / Q000502:physiology*; D000544:Alzheimer Disease / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D006801:Humans; D018384:Oxidative Stress; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D000975:Antioxidants; D017382:Reactive Oxygen Species