title: Acquired ichthyosis as a manifestation of acute cutaneous graft-versus-host disease.
abstract: Acquired ichythosis has been described in adult hematopoietic stem cell transplant recipients. While some authors have suggested the association of acquired ichythosis with cutaneous graft-versus-host disease, the evidence to support this association is rare. We describe a patient who developed enteritis secondary to acute graft-versus-host disease and had concomitant ichthyosiform lesions. Several months later, he was diagnosed with cutaneous graft-versus-host disease. This patient is presented to suggest that acquired ichthyosis is an underrecognized manifestation of acute cutaneous graft-versus-host disease. Given the important prognostic implications of this diagnosis, we recommend a low threshold for performing a skin biopsy to rule out GVHD in the appropriate clinical setting.
authors.affiliation: Department of Pediatrics, Columbia University, 161 Fort Washington Avenue, New York. NY 10032, USA.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Huang
authors.forename: Marlyanne
authors.initials: M
authors.lastname: Pol-Rodriguez
authors.forename: David
authors.initials: D
authors.lastname: Silvers
authors.forename: Maria C
authors.initials: MC
authors.lastname: Garzon
mesh_terms: D001706:Biopsy; D002648:Child; D004751:Enteritis / Q000209:etiology*; D006086:Graft vs Host Disease / Q000150:complications* / Q000175:diagnosis*; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D007057:Ichthyosis / Q000209:etiology* / Q000473:pathology; D008297:Male