title: Anti-Hebbian long-term potentiation in the hippocampal feedback inhibitory circuit.
abstract: Long-term potentiation (LTP), which approximates Hebb's postulate of associative learning, typically requires depolarization-dependent glutamate receptors of the NMDA (N-methyl-D-aspartate) subtype. However, in some neurons, LTP depends instead on calcium-permeable AMPA-type receptors. This is paradoxical because intracellular polyamines block such receptors during depolarization. We report that LTP at synapses on hippocampal interneurons mediating feedback inhibition is "anti-Hebbian":Itis induced by presynaptic activity but prevented by postsynaptic depolarization. Anti-Hebbian LTP may occur in interneurons that are silent during periods of intense pyramidal cell firing, such as sharp waves, and lead to their altered activation during theta activity.
authors.affiliation: Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK.
authors.forename: Karri P
authors.initials: KP
authors.lastname: Lamsa
authors.forename: Joost H
authors.initials: JH
authors.lastname: Heeroma
authors.forename: Peter
authors.initials: P
authors.lastname: Somogyi
authors.forename: Dmitri A
authors.initials: DA
authors.lastname: Rusakov
authors.forename: Dimitri M
authors.initials: DM
authors.lastname: Kullmann
mesh_terms: D000818:Animals; D004558:Electric Stimulation; D019706:Excitatory Postsynaptic Potentials; D006624:Hippocampus / Q000166:cytology / Q000502:physiology*; D007395:Interneurons / Q000502:physiology*; D017774:Long-Term Potentiation; D008297:Male; D008564:Membrane Potentials; D009433:Neural Inhibition / Q000502:physiology*; D018408:Patch-Clamp Techniques; D017966:Pyramidal Cells / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D018091:Receptors, AMPA / Q000502:physiology; D016194:Receptors, N-Methyl-D-Aspartate / Q000502:physiology; D013096:Spermine / Q000031:analogs & derivatives / Q000494:pharmacology; D013569:Synapses / Q000502:physiology*
chemical_list: D018091:Receptors, AMPA; D016194:Receptors, N-Methyl-D-Aspartate; D013096:Spermine