[Effect of ronkoleukin on nitric oxide and lipid peroxidation indices in hepatocarcinogenesis].
Hepatocarcinogenesis induced by DENA lead to increase in NO2 level, decrease in L-Arginin and Malonic Di-aldehyde (MDA) levels. The use of doksorubicyn slightly increases L-Arginin level in blood serum in mice without affecting considerably nitrite levels. Doksorubicin application in combination with ronkoleukin enables profound consumption of L-Arginin, increases nitrite levels and MDA. It is likely connected with increased formation of peroxynitrite which negatively affects tumor cells.
Kasymova
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GG
D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use*; D001120:Arginine / Q000097:blood; D004317:Doxorubicin / Q000008:administration & dosage / Q000627:therapeutic use; D007376:Interleukin-2 / Q000008:administration & dosage / Q000627:therapeutic use; D015227:Lipid Peroxidation / Q000187:drug effects*; D008114:Liver Neoplasms, Experimental / Q000188:drug therapy* / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D009566:Nitrates / Q000097:blood; D009569:Nitric Oxide / Q000378:metabolism*; D051381:Rats; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000627:therapeutic use; D016896:Treatment Outcome
D007376:Interleukin-2; D009566:Nitrates; D011994:Recombinant Proteins; D009569:Nitric Oxide; D008315:Malondialdehyde; D004317:Doxorubicin; D001120:Arginine