Adherence and plasma drug concentrations are predictors of confirmed virologic response after 24-week salvage highly active antiretroviral therapy.
Data from 197 patients for whom highly active antiretroviral therapy (HAART) failed, who started a new regimen chosen under the guide of resistance testing results interpreted by experts, were retrospectively studied, provided that at least 2 determinations of adherence and plasma drug concentrations were performed during the follow-up. Univariate and multivariable logistic regression analyses were conducted, using confirmed virologic response at week 24 as outcome measure (i.e., achievement of undetectable HIV plasma viral load at any time point before week 24 and its maintenance up to week 24). Suboptimal drug concentrations (odds ratio [OR]: 0.3; 95% confidence interval [CI] 0.2-0.7; p = 0.006) and suboptimal adherence (OR: 0.4; 95% CI 0.2-0.8; p = 0.014) were both negative independent predictors of sustained virologic response, while the use of boosted protease inhibitor-containing regimens resulted to be protective (OR: 2.4; 95% CI 1.1-5.3; p = 0.032).
Quiros-Roldan
Eugenia
E
Institute for Infectious and Tropical Diseases, University of Brescia, Brescia, Italy.
Torti
Carlo
C
Lapadula
Giuseppe
G
Ladisa
Nicoletta
N
Micheli
Valeria
V
Patroni
Andrea
A
Cusato
Maria
M
Pierotti
Piera
P
Tirelli
Valeria
V
Uccelli
Maria Cristina
MC
Di Giambenedetto
Simona
S
Castelnuovo
Filippo
F
Gargiulo
Franco
F
Manca
Nino
N
Carosi
Giampiero
G
D000328:Adult; D019380:Anti-HIV Agents / Q000008:administration & dosage* / Q000097:blood* / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active; D005260:Female; D015658:HIV Infections / Q000188:drug therapy* / Q000821:virology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010349:Patient Compliance; D016879:Salvage Therapy; D019562:Viral Load
D019380:Anti-HIV Agents