Glycogen synthase kinase 3beta (GSK3beta) regulates differentiation and proliferation in neural stem cells from the rat subventricular zone.
On the basis of its inhibition by SB216763, we identified the multifunctional enzyme Glycogen Synthase Kinase 3beta (GSK3beta) as a central regulator for differentiation and cell survival of adult neural stem cells. Detected by proteomic approaches, members of the Wnt/beta-catenin signaling pathway appear to participate in enhanced neuronal differentiation and activated transcription of beta-catenin target genes during GSK3beta inhibition, associated with decreased apoptosis.
Maurer
Martin H
MH
Department of Physiology and Pathophysiology, Division of Systems Physiology, University of Heidelberg, Im Neuenheimer Feld 326, 69120 Heidelberg, Germany. maurer@physiologie.uni-heidelberg.de
Brömme
Jens O
JO
Feldmann
Robert E
RE
Järve
Anne
A
Sabouri
Fatemeh
F
Bürgers
Heinrich F
HF
Schelshorn
Dominik W
DW
Krüger
Carola
C
Schneider
Armin
A
Kuschinsky
Wolfgang
W
D000818:Animals; D017209:Apoptosis; D002454:Cell Differentiation; D049109:Cell Proliferation; D002552:Cerebral Ventricles / Q000166:cytology*; D015180:Electrophoresis, Gel, Two-Dimensional; D038362:Glycogen Synthase Kinase 3 / Q000502:physiology*; D000071679:Glycogen Synthase Kinase 3 beta; D009474:Neurons / Q000166:cytology* / Q000201:enzymology; D040901:Proteomics / Q000379:methods; D051381:Rats; D013234:Stem Cells / Q000166:cytology* / Q000201:enzymology; D051153:Wnt Proteins / Q000378:metabolism; D051176:beta Catenin / Q000235:genetics / Q000378:metabolism
D051153:Wnt Proteins; D051176:beta Catenin; D000071679:Glycogen Synthase Kinase 3 beta; C000605508:Gsk3b protein, rat; D038362:Glycogen Synthase Kinase 3