title: Plasma levels of uridine correlate with blood pressure and indicators of myogenic purine degradation and insulin resistance in hypertensive patients.
abstract: BACKGROUND
  The relationship between plasma uridine levels and blood pressure (BP), and indicators of muscular purine degradation and insulin resistance (IR) has been evaluated in hypertensive (HT) patients.
  
  
  RESULTS
  In 36 HT patients and 10 normotensive subjects, seated BP was measured, and blood samples were drawn after overnight fast. In 18 of the HT patients, the semi-ischemic forearm test was performed to examine the release of hypoxanthine, ammonium and lactate. Plasma uridine levels were significantly higher than in the normotensive subjects. Fasting plasma insulin levels and homeostasis model assessment of IR correlated with plasma uridine levels in the HT patients. Plasma uridine levels showed a significant correlation with hypoxanthine, ammonia and lactate released from the semi-ischemic exercising muscles of the HT patients.
  
  
  CONCLUSIONS
  Taken together with the positive correlation with indicators of IR, it is suggested that plasma uridine levels in HT are responsible for purine degradation and IR in skeletal muscles.
authors.affiliation: Department of Cardiovascular Medicine, Graduate School of Medical Science, Tottori University, Yonago, Japan. thammer@chukai.ne.jp
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Hamada
authors.forename: Einosuke
authors.initials: E
authors.lastname: Mizuta
authors.forename: Kiyotaka
authors.initials: K
authors.lastname: Yanagihara
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Kaetsu
authors.forename: Shinobu
authors.initials: S
authors.lastname: Sugihara
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Sonoyama
authors.forename: Yasutaka
authors.initials: Y
authors.lastname: Yamamoto
authors.forename: Masahiko
authors.initials: M
authors.lastname: Kato
authors.forename: Osamu
authors.initials: O
authors.lastname: Igawa
authors.forename: Chiaki
authors.initials: C
authors.lastname: Shigemasa
authors.forename: Taku
authors.initials: T
authors.lastname: Inokuchi
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Yamamoto
authors.forename: Toshio
authors.initials: T
authors.lastname: Shimada
authors.forename: Akira
authors.initials: A
authors.lastname: Ohtahara
authors.forename: Haruaki
authors.initials: H
authors.lastname: Ninomiya
authors.forename: Ichiro
authors.initials: I
authors.lastname: Hisatome
mesh_terms: D000641:Ammonia / Q000378:metabolism; D001794:Blood Pressure; D016022:Case-Control Studies; D015444:Exercise; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000378:metabolism*; D019271:Hypoxanthine / Q000378:metabolism; D007333:Insulin Resistance; D007511:Ischemia / Q000378:metabolism; D019344:Lactic Acid / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000378:metabolism*; D011687:Purines / Q000378:metabolism*; D014529:Uridine / Q000097:blood*
chemical_list: D011687:Purines; D019271:Hypoxanthine; D019344:Lactic Acid; D000641:Ammonia; D014529:Uridine