Synthetic cinnamylphenol derivatives as cancer chemopreventive agents.
Several substituted cinnamylphenol (1,3-diphenylpropene) derivatives were synthesized and tested for their inhibitory activities against in vitro Epstein-Barr virus early antigen activation induced by 12-O-tetradecanoylphorbol-13-acetate in Raji cells. The prenylated cinnamylphenols were found to show remarkably potent activity. Furthermore, prenylated cinnamylphenols (19 and 25) exhibited a marked inhibitory effect on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test. These results indicate that some prenylated cinnamylphenols might be valuable as potential cancer chemopreventive agents (anti-tumor promoters).
Ito
Chihiro
C
Faculty of Pharmacy, Meijo University, Tempaku-ku, Nagoya 468-8503, Japan.
Itoigawa
Masataka
M
Kanematsu
Tetsufumi
T
Imamura
Yuuki
Y
Tokuda
Harukuni
H
Nishino
Hoyoku
H
Furukawa
Hiroshi
H
D000475:Alkenes / Q000138:chemical synthesis* / Q000494:pharmacology*; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004854:Herpesvirus 4, Human; D006801:Humans; D051379:Mice; D015394:Molecular Structure; D009369:Neoplasms / Q000473:pathology / Q000517:prevention & control*; D009374:Neoplasms, Experimental / Q000473:pathology / Q000517:prevention & control; D010636:Phenols / Q000138:chemical synthesis* / Q000494:pharmacology*; D013997:Time Factors
D000475:Alkenes; D000970:Antineoplastic Agents; D010636:Phenols