title: Antiproliferative and apoptotic effects of mycophenolic acid in human B-cell non-Hodgkin lymphomas.
abstract: Mycophenolic acid (MPA)/mycophenolate mofetil (MMF), a powerful immunosuppressive agent was tested on human B-lymphoma cells (Epstein-Barr virus +/-) in vitro and in SCID mouse xenograft model. Proliferation, apoptotic activity and tumor volume were evaluated. MPA inhibited lymphoma cell proliferation and induced apoptosis (50-60% at 72 h). In vivo, oral administration significantly inhibited subcutaneous tumor growth. Immunohistochemistry showed significantly decreased proliferation rate and higher apoptotic activity in tumors treated with MMF. Xenografted lymphoma cells remained sensitive to MPA. Our results suggest that MPA may be recommended as an additional component of lymphoma chemotherapeutical regimens, with special considerations to post-transplant lymphomas.
authors.affiliation: Semmelweis University, Department of Transplantation and Surgery, Budapest, Hungary.
authors.forename: Gyula
authors.initials: G
authors.lastname: Végso
authors.forename: Anna
authors.initials: A
authors.lastname: Sebestyén
authors.forename: Sándor
authors.initials: S
authors.lastname: Paku
authors.forename: Gábor
authors.initials: G
authors.lastname: Barna
authors.forename: Melinda
authors.initials: M
authors.lastname: Hajdu
authors.forename: Mária
authors.initials: M
authors.lastname: Tóth
authors.forename: Jeno
authors.initials: J
authors.lastname: Járay
authors.forename: László
authors.initials: L
authors.lastname: Kopper
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D002453:Cell Cycle / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects*; D005434:Flow Cytometry; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000378:metabolism; D006801:Humans; D007124:Immunoenzyme Techniques; D016393:Lymphoma, B-Cell / Q000378:metabolism / Q000473:pathology*; D051379:Mice; D016513:Mice, SCID; D009173:Mycophenolic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D009389:Neovascularization, Pathologic / Q000517:prevention & control*; D023041:Xenograft Model Antitumor Assays
chemical_list: D000970:Antineoplastic Agents; D009173:Mycophenolic Acid