title: Limonoids from the seeds of the marine mangrove Xylocarpus granatum.
abstract: Five new limonoids, granaxylocarpins A-E (1-5), were isolated from the seeds of the Chinese marine mangrove Xylocarpus granatum. Granaxylocarpins A (1) and B (2) are mexicanolide-type limonoids with a 9,10-seco skeleton, and granaxylocarpin C (3) possesses an 8alpha,30alpha-epoxy ring and a rare 1,29-oxygen bridge. The structures of these limonoids were characterized on the basis of extensive spectroscopic methods and single-crystal X-ray diffraction analysis performed on 4. The structure of xyloccensin U (4a) was revised as 4b by comparison with granaxylocarpin D (4). The cytotoxicity of these isolates was evaluated against the P-388 and A-549 tumor cell lines.
authors.affiliation: State Key Laboratory of Drug Research, Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, People's Republic of China.
authors.forename: Sheng
authors.initials: S
authors.lastname: Yin
authors.forename: Xiao-Ning
authors.initials: XN
authors.lastname: Wang
authors.forename: Cheng-Qi
authors.initials: CQ
authors.lastname: Fan
authors.forename: Li-Ping
authors.initials: LP
authors.lastname: Lin
authors.forename: Jian
authors.initials: J
authors.lastname: Ding
authors.forename: Jian-Min
authors.initials: JM
authors.lastname: Yue
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D007941:Leukemia P388; D036701:Limonins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D029582:Meliaceae / Q000737:chemistry*; D051379:Mice; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*; D012639:Seeds / Q000737:chemistry
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D036701:Limonins