Peculiar binding of botulinum neurotoxins.
Botulinum neurotoxin (BoNT) is a bacterial toxin that causes paralysis. Recent models have suggested that BoNT recognizes and enters nerve endings by interacting with protein receptors and gangliosides, which are glycosphingolipid components of the cell membrane that modulate cell signaling. Recent structures provide insight into how BoNT interacts with these cell surface components and open the door for the development of inhibitors against this neurotoxin.
Rossetto
Ornella
O
Dipartimento di Scienze Biomediche and Istituto CNR di Neuroscienze, Università di Padova, Viale G. Colombo 3, 35121 Padova, Italy. ornella.rossetto@unipd.it
Montecucco
Cesare
C
D000818:Animals; D001905:Botulinum Toxins / Q000378:metabolism*; D005732:Gangliosides; D006801:Humans; D009411:Nerve Endings / Q000378:metabolism*; D009498:Neurotoxins / Q000378:metabolism*; D011485:Protein Binding; D011956:Receptors, Cell Surface
D005732:Gangliosides; D009498:Neurotoxins; D011956:Receptors, Cell Surface; D001905:Botulinum Toxins