title: gp96 leads the way for toll-like receptors.
abstract: The role of the gp96 heat-shock protein in regulating Toll-like-receptor expression is incompletely understood. Yang et al. (2007) generated mice with conditional deficiency of gp96 in macrophages and found that this protein is an important chaperone for all Toll-like receptors that have been tested.
authors.affiliation: Department of Pathology, Wolstein 5534, Case Western Reserve University, 2103 Cornell Road, Cleveland, OH 44106-7288, USA. cvh3@cwru.edu
authors.forename: Clifford V
authors.initials: CV
authors.lastname: Harding
mesh_terms: D000818:Animals; D006801:Humans; D008264:Macrophages / Q000276:immunology; D008562:Membrane Glycoproteins / Q000276:immunology* / Q000378:metabolism; D051379:Mice; D018448:Models, Immunological; D018832:Molecular Chaperones / Q000276:immunology* / Q000378:metabolism; D051193:Toll-Like Receptors / Q000276:immunology* / Q000378:metabolism
chemical_list: D008562:Membrane Glycoproteins; D018832:Molecular Chaperones; D051193:Toll-Like Receptors; C053387:endoplasmin