Searching for non-invasive markers of tissue hypoxia.
Tissue hypoxia is a common end product of circulatory shock and a primary target for resuscitation efforts. In this issue Podbregar and Mozina show that thenar tissue O2 saturation (StO2) and mixed venous O2 saturation (SvO2) co-vary in patients in left ventricular failure, but in patients with sepsis StO2 was higher than SvO2. Although StO2 may co-vary with SvO2 they have different determinants such that after shock StO2 may increase well before SvO2 as a result of increased O2 demands to repay O2 debt incurred during hypoperfusion. Thus, the use of StO2 alone to define the endpoint of resuscitation may be misleading.
Puyana
Juan Carlos
JC
Applied Research IMITs Center, Innovative Medical & Information Technology Center, UPMC, F1265 Presbyterian, Pittsburgh, PA 15213-2536, USA.
Pinsky
Michael R
MR
D015415:Biomarkers / Q000378:metabolism; D002303:Cardiac Output, Low / Q000378:metabolism; D006333:Heart Failure / Q000378:metabolism*; D006801:Humans; D000860:Hypoxia / Q000175:diagnosis* / Q000378:metabolism; D018482:Muscle, Skeletal / Q000378:metabolism*; D010100:Oxygen / Q000378:metabolism*; D018805:Sepsis / Q000378:metabolism; D018487:Ventricular Dysfunction, Left / Q000378:metabolism
D015415:Biomarkers; D010100:Oxygen