title: Bioactive metabolites from the Caribbean sponge Aka coralliphagum.
abstract: The chemistry of the burrowing sponge Aka coralliphagum was investigated to identify chemically labile secondary metabolites. The HPLC-MS analysis of the two growth forms typica and incrustans revealed different metabolites. The previously unknown sulfated compounds siphonodictyals B1 to B3 (6-8), corallidictyals C (9) and D (10), and siphonodictyal G (11) were isolated, and their structures were elucidated by NMR and MS experiments. The compounds were tested in a DPPH assay, in antimicrobial assays against bacteria, yeasts, and fungi, and in antiproliferation assays using cultures of mouse fibroblasts. The biological activity was linked to the presence of the ortho-hydroquinone moiety.
authors.affiliation: Alfred-Wegener-Institut für Polar- und Meeresforschung in der Helmholtz-Gemeinschaft, Am Handelshafen 12, D-27570 Bremerhaven, Germany.
authors.forename: Achim
authors.initials: A
authors.lastname: Grube
authors.forename: Michael
authors.initials: M
authors.lastname: Assmann
authors.forename: Ellen
authors.initials: E
authors.lastname: Lichte
authors.forename: Florenz
authors.initials: F
authors.lastname: Sasse
authors.forename: Joseph R
authors.initials: JR
authors.lastname: Pawlik
authors.forename: Matthias
authors.initials: M
authors.lastname: Köck
mesh_terms: D000818:Animals; D001232:Aspergillus fumigatus / Q000187:drug effects; D001713:Biphenyl Compounds; D017691:Caribbean Region; D002851:Chromatography, High Pressure Liquid; D004354:Drug Screening Assays, Antitumor; D004926:Escherichia coli / Q000187:drug effects; D005347:Fibroblasts / Q000187:drug effects; D051379:Mice; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010851:Picrates / Q000494:pharmacology; D011161:Porifera / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D001713:Biphenyl Compounds; D010851:Picrates; D012717:Sesquiterpenes; C004931:1,1-diphenyl-2-picrylhydrazyl