title: Effect of beta blockers (carvedilol or metoprolol XL) in patients with transposition of great arteries and dysfunction of the systemic right ventricle.
abstract: This study evaluated the effects of beta blockers (carvedilol and metoprolol XL) on New York Heart Association functional class and systemic right ventricular (RV) function in patients with complete transposition of the great arteries who had systemic RV dysfunction late after atrial inflow correction. A significant improvement in New York Heart Association functional class was found after 4 months of therapy with beta blockers. Functional recovery was significant mostly in those patients with pacemakers who received higher maintenance doses of carvedilol. RV end-diastolic area was significantly greater in untreated patients at the end of the follow-up period, whereas it was unchanged in treated patients. In conclusion, beta blockers prevent RV remodeling, with a concomitant improvement in exercise tolerance in patients with complete transposition of the great arteries and systemic RV dysfunction.
authors.affiliation: Adult Congenital Cardiac Program, Emory University School of Medicine, Atlanta, Georgia, USA. adougha@emory.edu
authors.forename: Abdul Rahman K
authors.initials: AR
authors.lastname: Doughan
authors.forename: Michael E
authors.initials: ME
authors.lastname: McConnell
authors.forename: Wendy M
authors.initials: WM
authors.lastname: Book
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D000328:Adult; D002227:Carbazoles / Q000627:therapeutic use*; D000077261:Carvedilol; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008790:Metoprolol / Q000031:analogs & derivatives* / Q000627:therapeutic use; D011412:Propanolamines / Q000627:therapeutic use*; D012189:Retrospective Studies; D013318:Stroke Volume / Q000502:physiology; D014188:Transposition of Great Vessels / Q000150:complications* / Q000000981:diagnostic imaging / Q000503:physiopathology; D016896:Treatment Outcome; D014463:Ultrasonography; D018497:Ventricular Dysfunction, Right / Q000150:complications* / Q000188:drug therapy* / Q000503:physiopathology
chemical_list: D000319:Adrenergic beta-Antagonists; D002227:Carbazoles; D011412:Propanolamines; D000077261:Carvedilol; D008790:Metoprolol