T-cell potential and development in vitro: the OP9-DL1 approach.
In vivo, T cells develop in the thymus from bone marrow-derived hematopoietic progenitors. Similarly, T cells can develop in vitro in model systems that mimic thymic function. The recent development of the OP9-DL1 cell culture system, a two-dimensional T-inductive environment, has provided greater access to the processes of commitment and development in T lymphocytes.
de Pooter
Renée
R
Department of Immunology, University of Toronto, Sunnybrook Research Institute, 2075 Bayview Avenue, Toronto, ON M4N 3M5, Canada.
Zúñiga-Pflücker
Juan Carlos
JC
D000818:Animals; D002454:Cell Differentiation; D002478:Cells, Cultured; D006801:Humans; D038041:Lymphopoiesis; D013601:T-Lymphocytes / Q000276:immunology*; D013950:Thymus Gland / Q000166:cytology* / Q000276:immunology*