EANM procedure guideline for radio-immunotherapy for B-cell lymphoma with 90Y-radiolabelled ibritumomab tiuxetan (Zevalin).
BACKGROUND
In January 2004, EMEA approved 90Y-radiolabelled ibritumomab tiuxetan, Zevalin, in Europe for the treatment of adult patients with rituximab-relapsed or -refractory CD20+ follicular B-cell non-Hodgkin's lymphoma. The number of European nuclear medicine departments using Zevalin is continuously increasing, since the therapy is often considered successful. The Therapy, Oncology and Dosimetry Committees have worked together in order to define some EANM guidelines on the use of Zevalin, paying particular attention to the problems related to nuclear medicine.


OBJECTIVE
The purpose of this guideline is to assist the nuclear medicine physician in treating and managing patients who may be candidates for radio-immunotherapy. The guideline also stresses the need for close collaboration with the physician(s) treating the patient for the underlying disease.
Tennvall
Jan
J
Department of Oncology, Lund University Hospital, 221 85, Lund, Sweden. Jan.Tennvall@med.lu.se
Fischer
Manfred
M
Bischof Delaloye
Angelika
A
Bombardieri
Emilio
E
Bodei
Lisa
L
Giammarile
Francesco
F
Lassmann
Michael
M
Oyen
Wim
W
Brans
Boudewijn
B
D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D006801:Humans; D016393:Lymphoma, B-Cell / Q000532:radiotherapy*; D009683:Nuclear Medicine / Q000592:standards*; D010818:Practice Patterns, Physicians' / Q000592:standards; D016499:Radioimmunotherapy / Q000592:standards*; D019275:Radiopharmaceuticals / Q000592:standards / Q000627:therapeutic use
D000911:Antibodies, Monoclonal; D019275:Radiopharmaceuticals; C422802:ibritumomab tiuxetan