title: Natural history of thyroid function in adults with Down syndrome--10-year follow-up study.
abstract: BACKGROUND
  The natural history of thyroid function in adults with Down syndrome (DS) is unknown.
  
  
  METHODS
  This study investigated annual thyroid function tests in 200 adults with DS over a 10-year period.
  
  
  RESULTS
  Transient and persistent thyroid dysfunction was common. The 5- and 10-year incidence of definite hypothyroidism was 0.9%-1.64% and 13.6%, respectively. Subclinical hypothyroidism was not found to be an early sign for definite hypothyroidism.
  
  
  CONCLUSIONS
  Routine screening for adults with DS who are euthyroid can be reduced to every 5 years rather than the present policy of every 1-2 years.
authors.affiliation: Greenfields, Kings Norton, Birmingham, UK. vprasher@compuserve.com
authors.forename: V
authors.initials: V
authors.lastname: Prasher
authors.forename: G
authors.initials: G
authors.lastname: Gomez
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D015897:Comorbidity; D004314:Down Syndrome / Q000453:epidemiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D018571:Sentinel Surveillance; D013959:Thyroid Diseases / Q000453:epidemiology*; D013960:Thyroid Function Tests / Q000379:methods; D013972:Thyrotropin; D013995:Time; D006113:United Kingdom / Q000453:epidemiology
chemical_list: D013972:Thyrotropin