title: Heinz body haemolytic anaemia in a dog secondary to ingestion of a zinc toy: a case report.
abstract: A 6-year-old Labrador retriever was referred for investigation of severe lethargy and suspected immune-mediated haemolytic anaemia. Clinical examination revealed pale mucous membranes and jaundice. Haematology demonstrated large numbers of Heinz bodies and a marked anaemia, which was strongly regenerative. Serum zinc concentrations were markedly elevated. Analysis of a metal toy vomited by the dog 3 days prior to presentation revealed it to be composed of almost pure zinc. A diagnosis of haemolytic anaemia secondary to acute zinc toxicity was made and supportive therapy instigated. There was a subsequent decrease in numbers of Heinz bodies and a rise in the haematocrit, and the dog made an uneventful recovery. Acute zinc toxicity resulting in haemolytic anaemia is rarely observed, and this case was also unusual in that the main clinicopathological finding was the presence of numerous Heinz bodies without other evidence of oxidative damage to red blood cells.
authors.affiliation: Department of Veterinary Medicine, Queen's Veterinary School Hospital, University of Cambridge, Madingley Road, Cambridge, CB3 0ES, UK. nb289@cam.ac.uk
authors.forename: Nicholas
authors.initials: N
authors.lastname: Bexfield
authors.forename: Joy
authors.initials: J
authors.lastname: Archer
authors.forename: Michael
authors.initials: M
authors.lastname: Herrtage
mesh_terms: D000208:Acute Disease; D000743:Anemia, Hemolytic / Q000097:blood / Q000139:chemically induced / Q000662:veterinary*; D000818:Animals; D003937:Diagnosis, Differential; D004283:Dog Diseases / Q000097:blood / Q000139:chemically induced*; D004285:Dogs; D005260:Female; D005547:Foreign Bodies / Q000150:complications / Q000662:veterinary; D006366:Heinz Bodies / Q000378:metabolism / Q000473:pathology; D016896:Treatment Outcome; D015032:Zinc / Q000097:blood / Q000506:poisoning*
chemical_list: D015032:Zinc