title: A comparison of ondansetron with promethazine for treating postoperative nausea and vomiting in patients who received prophylaxis with ondansetron: a retrospective database analysis.
abstract: BACKGROUND
  There are little data on the efficacy of antiemetics for treating postoperative nausea and vomiting (PONV) in patients who received prior PONV prophylaxis.
  
  
  METHODS
  In this retrospective database analysis, we compared the efficacy of ondansetron with that of promethazine for treating PONV in adults receiving general anesthesia who failed ondansetron prophylaxis.
  
  
  RESULTS
  Three thousand sixty-two patients received ondansetron and 752 received promethazine after failure of ondansetron prophylaxis. The complete response (no PONV and no further rescue) was 68% after administration of promethazine and 50% after ondansetron administration (P < 0.0001). There was no difference in complete response between 6.25 mg and higher doses of promethazine.
  
  
  CONCLUSIONS
  Promethazine was significantly more effective than ondansetron for treating PONV after failed ondansetron prophylaxis. Promethazine 6.25 mg was as effective as higher doses.
authors.affiliation: Department of Anesthesiology, Duke University Medical Center, Durham, NC, 27710, USA. habib001@mc.duke.edu
authors.forename: Ashraf S
authors.initials: AS
authors.lastname: Habib
authors.forename: Johnatan
authors.initials: J
authors.lastname: Reuveni
authors.forename: Akiko
authors.initials: A
authors.lastname: Taguchi
authors.forename: William D
authors.initials: WD
authors.lastname: White
authors.forename: Tong J
authors.initials: TJ
authors.lastname: Gan
mesh_terms: D000328:Adult; D000768:Anesthesia, General / Q000009:adverse effects*; D000932:Antiemetics / Q000627:therapeutic use; D000982:Antipruritics / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008499:Medical Records; D008875:Middle Aged; D017294:Ondansetron / Q000627:therapeutic use*; D011183:Postoperative Complications; D020250:Postoperative Nausea and Vomiting / Q000188:drug therapy*; D011398:Promethazine / Q000627:therapeutic use*; D012189:Retrospective Studies; D012702:Serotonin Antagonists / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000932:Antiemetics; D000982:Antipruritics; D012702:Serotonin Antagonists; D017294:Ondansetron; D011398:Promethazine