title: Sinugrandisterols A-D, trihydroxysteroids from the soft coral Sinularia grandilobata.
abstract: Four new trihydroxysteroids, sinugrandisterols A-D (1-4), have been isolated from the CH(2)Cl(2)-soluble fraction of the EtOH extract of Sinularia grandilobata. The structures of these metabolites were determined on the basis of spectroscopic (IR, MS, and 1D and 2D NMR) analysis. The cytotoxicity of 1-4 toward a limited panel of cancer cell lines is also reported.
authors.affiliation: Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan.
authors.forename: Atallah F
authors.initials: AF
authors.lastname: Ahmed
authors.forename: Shu-Hui
authors.initials: SH
authors.lastname: Tai
authors.forename: Yang-Chang
authors.initials: YC
authors.lastname: Wu
authors.forename: Jyh-Horng
authors.initials: JH
authors.lastname: Sheu
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D002775:Cholestadienols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D006888:Hydroxycholesterols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006914:Hydroxysteroids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D013055:Spectrophotometry, Infrared; D014407:Tumor Cells, Cultured
chemical_list: C520758:24-methylenecholest-5-en-1,3,7-triol; C520760:5,6-epoxy-24-methylenecholesta-1,3,7-triol; C520759:5,6-epoxy-24-methylenecholesta-5,22-dien-1,3,7-triol; D000970:Antineoplastic Agents; D002775:Cholestadienols; D006888:Hydroxycholesterols; D006914:Hydroxysteroids