title: Studies on bacteriocin (thermophilin T) production by Streptococcus thermophilus ACA-DC 0040 in batch and fed-batch fermentation modes.
abstract: Growth conditions that support bacteriocin (thermophilin T) production by Streptococcus thermophilus ACA-DC 0040 were identified. Synthesis of thermophilin T occurred during primary metabolic growth, while its specific rate of synthesis seemed to be optimal at T = 30 degrees C. Thermophilin T activity rapidly decreased in the stationary phase, especially at high growth temperature (i.e. T = 42 degrees C). In media with high content of complex nitrogen sources, high amounts of bacteriocin were detected in the growth environment, while about an 8-fold increase of thermophilin T titer and a 2-fold increase of specific synthesis rate was achieved when a fed-batch fermentation mode was applied.
authors.affiliation: Laboratory of Dairy Research, Department of Food Science and Technology, Agricultural University of Athens, Iera Odos 75, Athens 11855, Greece. aktyp@aua.gr
authors.forename: Anastasios
authors.initials: A
authors.lastname: Aktypis
authors.forename: Matheus
authors.initials: M
authors.lastname: Tychowski
authors.forename: George
authors.initials: G
authors.lastname: Kalantzopoulos
authors.forename: George
authors.initials: G
authors.lastname: Aggelis
mesh_terms: D001430:Bacteriocins / Q000096:biosynthesis*; D019149:Bioreactors; D005285:Fermentation; D005947:Glucose; D009584:Nitrogen; D048249:Streptococcus thermophilus / Q000145:classification / Q000378:metabolism*; D013997:Time Factors
chemical_list: D001430:Bacteriocins; C523172:thermophilin T, Streptococcus thermophilus; D005947:Glucose; D009584:Nitrogen