title: Association between sensitization to Aureobasidium pullulans (Pullularia sp) and severity of asthma.
abstract: BACKGROUND
  Recent data indicate that fungi may contribute to increased severity of asthma.
  
  
  OBJECTIVE
  To determine the prevalence of allergy to 15 mold allergens among patients hospitalized because of exacerbation of asthma and to evaluate the relationship between the severity of the disease and allergy to particular molds.
  
  
  METHODS
  Skin prick tests with standard aeroallergens of airborne allergens, including grass, tree, Dermatophagoides pteronyssinus, Dermatophagoides farinae, feather, and cat and dog fur, and a panel of mold allergens, including Alternaria, Cladosporium, Aspergillus, Penicillium, Trichothecium, Chaetomium globosum, Epicoccum, Epidermophyton, Helminthosporium, Aureobasidium pullulans, Rhizopus nigricans, Fusarium, Mucor, Merulius lacrymans, and yeast mix, were performed in 105 asthmatic patients and 30 controls.
  
  
  RESULTS
  Positive skin prick test results were found in 98% of asthmatic patients and 66% of controls. Sensitivity to A pullulans was significantly associated with more severe asthma (odds ratio, 1.4; 95% confidence interval, 1.09-1.75; P = .006). Sensitization to Helminthosporium was associated with an increased number of asthma exacerbations that required hospitalization (17% vs 38%; chi2 test P = .03).
  
  
  CONCLUSIONS
  Sensitization to A pullulans is a risk factor for severe asthma. Sensitization to Helminthosporium may be related to asthma exacerbation that requires hospitalization.
authors.affiliation: Department of Allergology, Medical University of Gdansk, Gdansk, Poland. mnied@amg.gda.pl
authors.forename: Marek
authors.initials: M
authors.lastname: Niedoszytko
authors.forename: Marta
authors.initials: M
authors.lastname: Chełmińska
authors.forename: Ewa
authors.initials: E
authors.lastname: Jassem
authors.forename: Eugenia
authors.initials: E
authors.lastname: Czestochowska
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000485:Allergens / Q000276:immunology*; D000946:Antigens, Fungal / Q000276:immunology*; D001249:Asthma / Q000453:epidemiology / Q000276:immunology*; D005260:Female; D005658:Fungi / Q000276:immunology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011044:Poland / Q000453:epidemiology; D012720:Severity of Illness Index; D012882:Skin Tests; D013147:Spirometry
chemical_list: D000485:Allergens; D000946:Antigens, Fungal