Evolution of the HIV-1 V3 region in the Italian epidemic.
The epidemic of Human Immunodeficiency Virus type 1 infection in Italy is mostly ascribed to the B subtype, which represents the prevalent subtype in Western Countries. The virus isolates of the B subtype, moreover, show an increasing nucleotide heterogeneity over time, indicating a continuous intra-subtype dynamic evolution, typical of long-lasting epidemics. In recent years, however, the progressive decrease in the transmission rate among the historically defined risk groups (i.e. homosexuals and IDUs) and the parallel increase in heterosexual transmission are slowly introducing variants of non-B subtype into the Italian HIV-1 epidemic. This appears to be strictly linked to the growing number of immigrants from non-Western Countries, where non-B clades and CRFs are prevalent, and consequent inter-racial blending. The distribution of these novel genetic forms needs to be evaluated by continuous molecular monitoring nationwide to verify whether they will overcome the pre-existing B-clade epidemic, which could have significant implications for diagnosis, treatment and vaccine development. Here we review the genetic evolution of HIV-1 spreading within the Italian epidemic.
Buonaguro
Luigi
L
Laboratory of Viral Oncogenesis and Immunotherapy and AIDS Reference Center, National Cancer Institute Fond. G. Pascale, Naples, Italy.
Tagliamonte
Maria
M
Tornesello
Marialina
M
Buonaguro
Franco M
FM
D003062:Codon / Q000235:genetics; D004196:Disease Outbreaks; D019143:Evolution, Molecular; D015699:HIV Envelope Protein gp120 / Q000235:genetics; D015658:HIV Infections / Q000453:epidemiology; D015497:HIV-1 / Q000145:classification / Q000235:genetics*; D006801:Humans; D007558:Italy / Q000453:epidemiology; D010446:Peptide Fragments / Q000235:genetics; D010802:Phylogeny
D003062:Codon; D015699:HIV Envelope Protein gp120; C059762:HIV envelope protein gp120 (305-321); D010446:Peptide Fragments