[Itraconazole for treatment of fungal infections in patients undergoing allogeneic hematopoietic stem cell transplantation].
OBJECTIVE
To investigate the effect of intravenous itraconazole on fungal infections in patients undergoing allogeneic hematopoietic stem cell transplantation.


METHODS
Seventy-five such patients treated with itraconazole from October, 2002 to October, 2005 were studied. The diagnosis of fungal infection was made according to the criteria recommended by Chinese workshop on invasive fungal infection (IFI). Four patients were definitely diagnosed as IFI, twenty-two patients probably and 49 patients possibly.


RESULTS
Fifty-seven of the 75 patients showed response to itraconazole therapy including 3 definite, 18 probable and 36 possible cases.


CONCLUSIONS
Fungal infections in patients undergoing allogeneic stem cell transplantation diagnosed according to the criteria recommended by Chinese workshop on IFI can be successfully treated with itraconazole.
Wang
Jing-zhi
JZ
Institute of Hematology, Peking University People's Hospital, Beijing 100044, China.
Liu
Dai-hong
DH
Xu
Lan-ping
LP
Chen
Huan
H
Liu
Kai-yan
KY
Huang
Xiao-jun
XJ
D000293:Adolescent; D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use*; D002648:Child; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D017964:Itraconazole / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009181:Mycoses / Q000188:drug therapy*; D014184:Transplantation, Homologous
D000935:Antifungal Agents; D017964:Itraconazole