title: Pathophysiology and treatment of neuropathic pain associated with syringomyelia.
abstract: The pain behaviour expressed by dogs with syringomyelia suggests that they experience neuropathic pain, probably due to disordered neural processing in the damaged dorsal horn. As such it is likely that conventional analgesic medication will be ineffective. In this review, physiological and pathological pain processing through the dorsal horn is summarised and mechanisms by which syringomyelia could result in a persistent pain state are discussed. Finally, current knowledge regarding treatment of Chiari malformation and syringomyelia is reviewed and possible drugs which may give improved pain relief in affected dogs are discussed.
authors.affiliation: Stone Lion Veterinary Centre, Wimbledon Village, London SW19 5AU, UK. neuro.vet@btinternet.com
authors.forename: Clare
authors.initials: C
authors.lastname: Rusbridge
authors.forename: Nick D
authors.initials: ND
authors.lastname: Jeffery
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000503:physiopathology* / Q000628:therapy*; D004285:Dogs; D010146:Pain / Q000150:complications / Q000662:veterinary*; D059408:Pain Management; D013595:Syringomyelia / Q000150:complications / Q000662:veterinary*