title: Risk factors for airway complications within the first year after lung transplantation.
abstract: OBJECTIVE
  Lung transplantation (LTx) has enjoyed increasing success with better survival in recent years. Nevertheless, airway anastomotic complications (AC) are still a potential cause of early morbidity and mortality. In this retrospective cohort study we looked at possible predictors of AC within the first year after LTx.
  
  
  METHODS
  Between July 1991 and December 2004, 232 consecutive single (n=102) and bilateral (n=130) LTx were performed (142 males and 90 females; mean age: 48 years [range 15-66 years]). Indications for LTx were emphysema (n=113), pulmonary fibrosis (n=45), cystic fibrosis (n=35), pulmonary hypertension (n=10), sarcoidosis (n=7) and miscellaneous (n=22). Donor variables (age, gender, PaO(2)/FiO(2), mechanical ventilation, ischemic time and preservation solution) and recipient variables (age, diagnosis, length, gender, pre-operative steroids, smoking, cytomegalovirus matching, LTx type, anastomotic type, wrapping and bypass) were evaluated in an univariate and multivariate model.
  
  
  RESULTS
  Fifty-seven complications occurred in 362 airway anastomoses (15.7%) of which 55 (15.2%) within the first year after transplantation. Six patients died as a result of AC (mortality 2.6%) during the first year after LTx. In a univariate analysis (321 airway anastomoses at risk), anastomotic type (7/17 [Telescoping] vs 48/304 [End-to-end]; p=0.011), recipient length (p=0.0012), donor ventilation (>50-70h<; p=0.0015) and recipient male gender (43/191 [M] vs 12/130 [F]; p=0.0092) were significant predictors of AC. Three factors remained significant predictors in the multivariate analysis: telescoping technique (p=0.0495), recipient length (p=0.0029) and donor ventilation (p=0.003).
  
  
  CONCLUSIONS
  Tall recipients and those receiving lungs from donors with prolonged ventilation have an increased risk to develop bronchial anastomotic problems. An end-to-end anastomosis should be preferred. Airway complications remain a matter of concern after lung transplantation.
authors.affiliation: Department of Thoracic Surgery, UZ Leuven, Belgium.
authors.forename: Caroline
authors.initials: C
authors.lastname: Van De Wauwer
authors.forename: Dirk
authors.initials: D
authors.lastname: Van Raemdonck
authors.forename: Geert M
authors.initials: GM
authors.lastname: Verleden
authors.forename: Lieven
authors.initials: L
authors.lastname: Dupont
authors.forename: Paul
authors.initials: P
authors.lastname: De Leyn
authors.forename: Willy
authors.initials: W
authors.lastname: Coosemans
authors.forename: Philippe
authors.initials: P
authors.lastname: Nafteux
authors.forename: Toni
authors.initials: T
authors.lastname: Lerut
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000714:Anastomosis, Surgical / Q000009:adverse effects / Q000379:methods; D001980:Bronchi / Q000098:blood supply / Q000503:physiopathology; D001982:Bronchial Diseases / Q000209:etiology* / Q000401:mortality / Q000503:physiopathology; D005260:Female; D006801:Humans; D008168:Lung / Q000098:blood supply / Q000601:surgery; D016040:Lung Transplantation / Q000401:mortality; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000209:etiology* / Q000401:mortality / Q000503:physiopathology; D012086:Reoperation; D012121:Respiration, Artificial; D012189:Retrospective Studies; D012307:Risk Factors; D012737:Sex Factors; D013997:Time Factors; D014945:Wound Healing / Q000502:physiology