Myoepithelial cells are the main component in pleomorphic adenomas?
OBJECTIVE
The aim of this study was to quantify by immunohistochemistry the number of myoepithelial cells (MyECs) in pleomorphic adenomas (PAs).


METHODS
We retrieved the paraffin cubes of 27 PAs, new slides were done and they were stained with anti-S100 protein antibody. The amount of S-100 protein positive cells was quantified, their morphology was recorded and comparison among MyEC number with age, gender and involved gland were also done.


RESULTS
With S-100 protein, MyECs in normal salivary gland tissue were seen surrounding the ductual structures only. In the analysed PAs a mean of 27.4% of the neoplastic cells were positive to the antibody. With the exception of one PA, in all the analysed cases the plasmacytoid cells were the most commonly identified cells (48,6%).


CONCLUSIONS
Results of this study suggest that MyECs do not constitute the main cellular component of the neoplastic compartment in PAs and corroborate the previously reported evidence by different authors, who studying the PAs suggested that MyECs does not comprise the main cellular neoplastic component of these entities.
Ponce Bravo
Santa
S
Laboratorio de Patología Clínica, División de Estudios de Posgrado e Investigación, Facultad de Odontología, UNAM, México, DF, México.
Ledesma Montes
Constantino
C
López Becerril
Uriel
U
Morales Sánchez
Israel
I
D008949:Adenoma, Pleomorphic / Q000737:chemistry / Q000473:pathology*; D000293:Adolescent; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009208:Myoepithelioma / Q000737:chemistry / Q000473:pathology*; D009418:S100 Proteins / Q000032:analysis*; D012468:Salivary Gland Neoplasms / Q000737:chemistry / Q000473:pathology*; D012737:Sex Factors
D014408:Biomarkers, Tumor; D009418:S100 Proteins