The genetic susceptibility to IgA nephropathy: a novel functional candidate gene for incomplete O-glycosylation of IgA1.
Incompleteness of O-glycosylation in the IgA1 hinge has been implicated as a central mechanism in the development of IgA nephropathy. Although underglycosylation was reported to be an acquired abnormality, genes for enzymes of O-glycosylation, such as C1GALT1, may be responsible for susceptibility to IgA nephropathy.
Narita
I
I
Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan. naritai@med.niigata-u.ac.jp
Kaneko
Y
Y
Kondo
D
D
Goto
S
S
Sakatsume
M
M
Gejyo
F
F
D005700:Galactosyltransferases / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D005922:Glomerulonephritis, IGA / Q000201:enzymology / Q000235:genetics*; D006031:Glycosylation; D006801:Humans; D007070:Immunoglobulin A / Q000378:metabolism*
D007070:Immunoglobulin A; C505293:C1GALT1 protein, human; D005700:Galactosyltransferases