title: Synthetic N-pyridinyl(methyl)-indol-3-ylpropanamides as new potential immunosuppressive agents.
abstract: Several N-pyridinyl(methyl)-indol-3-ylpropanamides were synthesized and pharmacological evaluations of their immunosuppressive potential were performed. Among thirteen compounds tested in vitro on murine T proliferation, three showed interesting inhibiting activity. For the most active compound (propanamide 18), immunosuppressive activity was documented both in vitro on human T lymphocytes proliferation and in vivo on mice delayed-type hypersensitivity. These experimental data demonstrated that these compounds hold potential as immunosuppressive agents.
authors.affiliation: Nantes University, Nantes Atlantique Universities, Immuno-Pharmacology Department, BioCiT, UPRES EA 1155, Faculty of Pharmacy, 1 rue Gaston Veil, Nantes, France.
authors.forename: Delphine
authors.initials: D
authors.lastname: Carbonnelle
authors.forename: Morgane
authors.initials: M
authors.lastname: Lardic
authors.forename: Alexandra
authors.initials: A
authors.lastname: Dassonville
authors.forename: Elise
authors.initials: E
authors.lastname: Verron
authors.forename: Jean-Yves
authors.initials: JY
authors.lastname: Petit
authors.forename: Muriel
authors.initials: M
authors.lastname: Duflos
authors.forename: François
authors.initials: F
authors.lastname: Lang
mesh_terms: D000577:Amides / Q000737:chemistry; D000818:Animals; D049109:Cell Proliferation; D005260:Female; D006801:Humans; D006968:Hypersensitivity, Delayed; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D007211:Indoles / Q000737:chemistry / Q000494:pharmacology*; D051379:Mice; D008807:Mice, Inbred BALB C; D011725:Pyridines / Q000737:chemistry / Q000494:pharmacology*; D013601:T-Lymphocytes / Q000187:drug effects
chemical_list: D000577:Amides; D007166:Immunosuppressive Agents; D007211:Indoles; D011725:Pyridines