The effect of dietary calcium and phosphorus supplementation in zeolite a treated dry cows on periparturient calcium and phosphorus homeostasis.
Previous studies have proved the possibility of preventing parturient hypocalcaemia by zeolite A supplementation during the dry period, and a recent in vitro study has indicated a marked calcium (Ca) as well as phosphorus (P) binding effect of zeolite A in rumen fluid solutions. Because of the connection between the Ca and P homeostatic systems, the preventive effect against parturient hypocalcaemia may arise from zeolite induced decreased availability of dietary Ca as well as P. In the present study, the expected Ca and P binding capacity was challenged by feeding high and low levels of dietary Ca and/or P to zeolite A treated dry cows. Twenty-one pregnant dry cows were assigned to four experimental groups receiving a dry cow ration unsupplemented or supplemented with extra Ca and/or P. During the last 2 weeks of the dry period all cows additionally received 600 g of zeolite A per day. A high level of dietary P prepartum significantly decreased the plasma Ca concentration before as well as immediately after calving (day 0-3). Conversely, the plasma inorganic phosphate concentration was higher among these cows than among cows receiving no supplemental P. The prepartum dietary Ca level significantly affected the serum 1,25-dihydroxyvitamin D concentration during zeolite supplementation, whereas the periparturient plasma Ca concentration was apparently not affected by the dietary Ca level. During zeolite A supplementation plasma parathyroid hormone was significantly higher among cows receiving additional P. The urinary deoxypyridinoline/creatinine ratio was not affected by the prepartal dietary Ca or P level. Serum aluminium (Al) was significantly higher during zeolite A supplementation than during the preceding period, indicating partial destruction of the zeolite in the intestinal tract with subsequent release and absorption of Al. It is suggested that the effect of prepartum zeolite supplementation on the periparturient Ca homeostasis depends on the level of Ca as well as P in the dry cow ration.
Thilsing
T
T
Department of Large Animal Sciences, Medicine and Surgery, The Royal Veterinary and Agricultural University, Ridebanevej 12, DK-1870 Frederiksberg C, Denmark. trh@kvl.dk
Larsen
T
T
Jørgensen
R J
RJ
Houe
H
H
D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002136:Calcium, Dietary / Q000008:administration & dosage*; D002417:Cattle / Q000378:metabolism / Q000502:physiology*; D002418:Cattle Diseases / Q000517:prevention & control; D019587:Dietary Supplements; D005260:Female; D006996:Hypocalcemia / Q000517:prevention & control / Q000662:veterinary; D009751:Nutritional Requirements; D036801:Parturition / Q000378:metabolism; D010758:Phosphorus / Q000378:metabolism*; D016226:Phosphorus, Dietary / Q000008:administration & dosage*; D011247:Pregnancy; D017641:Zeolites
D002136:Calcium, Dietary; D016226:Phosphorus, Dietary; D017641:Zeolites; D010758:Phosphorus; D002118:Calcium