Receptor tyrosine kinases: mechanisms of activation and signaling.
Receptor tyrosine kinases (RTKs) are essential components of signal transduction pathways that mediate cell-to-cell communication. These single-pass transmembrane receptors, which bind polypeptide ligands - mainly growth factors - play key roles in processes such as cellular growth, differentiation, metabolism and motility. Recent progress has been achieved towards an understanding of the precise (and varied) mechanisms by which RTKs are activated by ligand binding and by which signals are propagated from the activated receptors to downstream targets in the cell.
Hubbard
Stevan R
SR
Skirball Institute of Biomolecular Medicine and Department of Pharmacology, New York University School of Medicine, New York, NY 10016, USA. hubbard@saturn.med.nyu.edu
Miller
W Todd
WT
D000818:Animals; D003067:Coenzymes / Q000378:metabolism; D004789:Enzyme Activation; D006801:Humans; D008024:Ligands; D008954:Models, Biological; D011487:Protein Conformation; D020239:Receptor Cross-Talk; D020794:Receptor Protein-Tyrosine Kinases / Q000378:metabolism*; D015398:Signal Transduction
D003067:Coenzymes; D008024:Ligands; D020794:Receptor Protein-Tyrosine Kinases