title: FDG-PET lymphoma demonstration project invitational workshop.
abstract: The proceedings of a workshop focusing on a project to evaluate the use of fluorodeoxyglucose-positron emission tomography (FDG-PET) as a tool to measure treatment response in non-Hodgkin lymphoma (NHL) are described. Sponsored by the Leukemia & Lymphoma Society, the Foundation of the National Institutes of Health, and the National Cancer Institute, and attended by representatives of the Food and Drug Administration, the Centers for Medicare and Medicaid Services, and scientists and clinical researchers from academia and the pharmaceutical and medical imaging industries, the workshop reviewed the etiology and current standards of care for NHL and proposed the development of a clinical trial to validate FDG-PET imaging techniques as a predictive biomarker for cancer therapy response. As organized under the auspices of the Oncology Biomarker Qualification Initiative, the three federal health agencies and their private sector and nonprofit/advocacy group partners believe that FDG-PET not only demonstrates the potential to be used for the diagnosis and staging of many cancers but in particular can provide an early indication of therapeutic response that is well correlated with clinical outcomes for chemotherapy for this common form of lymphoma. The development of standardized criteria for FDG-PET imaging and establishment of procedures for transmission, storage, quality assurance, and analysis of PET images afforded by this demonstration project could streamline clinical trials of new treatments for more intractable forms of lymphoma and other cancers and, hence, accelerate new drug approvals.
authors.affiliation: National Institutes of Health (NIH)/National Cancer Institute (NCI)/Division of Cancer Treatment and Diagnosis (DCTD)/Cancer Imaging Program, Bethesda, MD, USA.
authors.forename: Gary J
authors.initials: GJ
authors.lastname: Kelloff
authors.forename: Daniel M
authors.initials: DM
authors.lastname: Sullivan
authors.forename: Wyndham
authors.initials: W
authors.lastname: Wilson
authors.forename: Bruce
authors.initials: B
authors.lastname: Cheson
authors.forename: Malik
authors.initials: M
authors.lastname: Juweid
authors.forename: George Q
authors.initials: GQ
authors.lastname: Mills
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Zelenetz
authors.forename: Sandra J
authors.initials: SJ
authors.lastname: Horning
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Weber
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Sargent
authors.forename: Lori
authors.initials: L
authors.lastname: Dodd
authors.forename: Edward
authors.initials: E
authors.lastname: Korn
authors.forename: James
authors.initials: J
authors.lastname: Armitage
authors.forename: Richard
authors.initials: R
authors.lastname: Schilsky
authors.forename: Michaele
authors.initials: M
authors.lastname: Christian
authors.forename: Owen A
authors.initials: OA
authors.lastname: O'connor
authors.forename: Sue Jane
authors.initials: SJ
authors.lastname: Wang
authors.forename: Ann T
authors.initials: AT
authors.lastname: Farrell
authors.forename: Richard
authors.initials: R
authors.lastname: Pazdur
authors.forename: Michael
authors.initials: M
authors.lastname: Graham
authors.forename: Richard L
authors.initials: RL
authors.lastname: Wahl
authors.forename: Steven M
authors.initials: SM
authors.lastname: Larson
authors.forename: Lale
authors.initials: L
authors.lastname: Kostakoglu
authors.forename: Margaret
authors.initials: M
authors.lastname: Daube-Witherspoon
authors.forename: Constantine
authors.initials: C
authors.lastname: Gastonis
authors.forename: Barry A
authors.initials: BA
authors.lastname: Siegel
authors.forename: Lalitha K
authors.initials: LK
authors.lastname: Shankar
authors.forename: David B
authors.initials: DB
authors.lastname: Lee
authors.forename: Howard R
authors.initials: HR
authors.lastname: Higley
authors.forename: Caroline C
authors.initials: CC
authors.lastname: Sigman
authors.forename: Daniel
authors.initials: D
authors.lastname: Carucci
authors.forename: David
authors.initials: D
authors.lastname: Timko
authors.forename: Louis J
authors.initials: LJ
authors.lastname: deGennaro
authors.forename: Ellen
authors.initials: E
authors.lastname: Sigal
authors.forename: Anna
authors.initials: A
authors.lastname: Barker
authors.forename: Janet
authors.initials: J
authors.lastname: Woodcock
mesh_terms: D017322:Clinical Trials, Phase II as Topic; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000000981:diagnostic imaging* / Q000188:drug therapy; D008297:Male; D049268:Positron-Emission Tomography; D011785:Quality Assurance, Health Care; D015203:Reproducibility of Results
chemical_list: D019788:Fluorodeoxyglucose F18