A new 2,3-dimethyl butenolide from the brittle star Ophiomastix mixta.
A new butenolide (1) was isolated, along with a known acyclic polyhalogenated monoterpene (2), from the brittle star Ophiomastix mixta. The structures were defined by analysis and comparision of the spectral data with those in the literature. The 2,3-dimethyl butenolide (1) is uncommon and first encountered in a marine organism. The compounds were tested for cytotoxicity against a panel of five human solid tumor cell lines and displayed mild to significant activity.
Lee
Jinsoo
J
College of Pharmacy, Pusan National University, Busan, Korea.
Wang
Weihong
W
Hong
Jongki
J
Lee
Chong-Ok
CO
Shin
Sook
S
Im
Kwang Sik
KS
Jung
Jee Hyung
JH
D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000737:chemistry* / Q000378:metabolism; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D004447:Echinodermata / Q000737:chemistry* / Q000378:metabolism*; D006801:Humans; D015394:Molecular Structure
D000970:Antineoplastic Agents; D015107:4-Butyrolactone