title: Colonization and turnover of Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis in otitis-prone children.
abstract: Recurrent otitis media are frequently intractable during childhood. It is unclear whether recurrent otitis media is caused by etiological bacteria colonization or by new infections. Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis were isolated from the nasopharynx of 7 otitisprone and 2 non-prone children with recurrent otitis media. Plural bacterial species and strains were found in all children while affected by otitis media. The same strain was repeatedly isolated from all otitisprone children even after administration of antibiotics but was not from the non-prone children. Antibiotic susceptibility did not differ significantly among the same repeatedly isolated strains. This pilot study suggests that the etiological bacteria tend to colonize and is hard to eliminate in otitis-prone children.
authors.affiliation: Department of Microbiology, Sapporo Medical University School of Medicine, Hokkaido, Japan.
authors.forename: Shin-Ichi
authors.initials: S
authors.lastname: Yokota
authors.forename: Atsushi
authors.initials: A
authors.lastname: Harimaya
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Sato
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Somekawa
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Himi
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Fujii
mesh_terms: D016667:Bacterial Capsules / Q000737:chemistry / Q000235:genetics; D002648:Child; D002675:Child, Preschool; D004269:DNA, Bacterial / Q000737:chemistry / Q000235:genetics; D006193:Haemophilus influenzae / Q000254:growth & development*; D006801:Humans; D008826:Microbial Sensitivity Tests; D001936:Moraxella catarrhalis / Q000254:growth & development*; D009304:Nasopharyngitis / Q000382:microbiology; D010033:Otitis Media / Q000382:microbiology*; D010865:Pilot Projects; D019105:Random Amplified Polymorphic DNA Technique; D013296:Streptococcus pneumoniae / Q000235:genetics / Q000254:growth & development*
chemical_list: D004269:DNA, Bacterial