title: Structured surveillance of infantile gastroenteritis in East Anglia, UK: incidence of infection with common viral gastroenteric pathogens.
abstract: The aim of this study was to investigate the burden of disease associated with gastroenteric viruses (rotavirus, norovirus, sapovirus, astrovirus and enteric adenovirus) using structured surveillance of children aged <6 years in the community. Faecal samples were collected between 2000 and 2003 from 685 children with symptoms of gastroenteritis. The children comprised three groups; 223 in the structured surveillance cohort, 203 in a community cohort and 259 in a cohort of hospitalized children. All samples were tested for the presence of viral pathogens using molecular methods. Questionnaires were sent to the parents/carers of the children recruited to the structured surveillance cohort in order to collect data that would allow an estimation of the severity of illness by means of the Vesikari score, and of the cost associated with gastrointestinal disease in this age group. A viral aetiological agent was detected in 53.5% of samples tested. Rotavirus was the most common pathogen found in all three cohorts followed by norovirus and enteric adenoviruses. Multiple viruses were found in 8% of the samples, and commonly involved rotavirus and any other virus. G1P[8] was the most commonly detected rotavirus strain and there was no significant difference in the distribution of rotavirus genotypes among the three cohorts. Analysis of the questionnaires indicated that rotavirus infections were likely to be more severe than any other virus infection, and children from whom a viral pathogen was identified were more likely to require rehydration therapy.
authors.affiliation: Enteric Virus Unit, Virus Reference Department, Centre for Infections, Health Protection Agency, London, UK. miren.iturriza@hpa.org.uk
authors.forename: M
authors.initials: M
authors.lastname: Iturriza Gómara
authors.forename: R
authors.initials: R
authors.lastname: Simpson
authors.forename: A M
authors.initials: AM
authors.lastname: Perault
authors.forename: C
authors.initials: C
authors.lastname: Redpath
authors.forename: P
authors.initials: P
authors.lastname: Lorgelly
authors.forename: D
authors.initials: D
authors.lastname: Joshi
authors.forename: M
authors.initials: M
authors.lastname: Mugford
authors.forename: C A
authors.initials: CA
authors.lastname: Hughes
authors.forename: J
authors.initials: J
authors.lastname: Dalrymple
authors.forename: U
authors.initials: U
authors.lastname: Desselberger
authors.forename: J
authors.initials: J
authors.lastname: Gray
mesh_terms: D002648:Child; D002673:Child, Hospitalized / Q000706:statistics & numerical data; D002675:Child, Preschool; D015331:Cohort Studies; D004279:DNA, Viral / Q000032:analysis; D003968:Diarrhea, Infantile / Q000453:epidemiology / Q000209:etiology / Q000473:pathology / Q000821:virology; D004739:England / Q000453:epidemiology; D005243:Feces / Q000821:virology; D005759:Gastroenteritis / Q000453:epidemiology* / Q000209:etiology / Q000473:pathology / Q000821:virology; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D016133:Polymerase Chain Reaction; D011159:Population Surveillance; D012401:Rotavirus / Q000235:genetics / Q000302:isolation & purification; D012621:Seasons; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires; D014777:Virus Diseases / Q000453:epidemiology / Q000209:etiology / Q000473:pathology / Q000821:virology
chemical_list: D004279:DNA, Viral