Natural and synthetic cholera toxin antagonists.
Cholera Toxin (CT) recognizes the cell membrane through specific interactions with ganglioside GM1. Recent structural elucidation of the CT/GM1 complex has allowed the rational design of artificial receptors for the toxin, which could function as anti-cholera drugs. The efforts towards the rational design of Cholera Toxin inhibitors will be presented.
Velter
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IA
Dipartimento di Biotecnologie e Bioscienze, Università degli Studi di Milano-Bicocca, Piazza della Scienza 2, I-20126 Milan, Italy.
Politi
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M
Podlipnik
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C
Nicotra
F
F
D001688:Biological Products / Q000737:chemistry* / Q000494:pharmacology*; D002772:Cholera Toxin / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000378:metabolism; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D008024:Ligands
D001688:Biological Products; D004791:Enzyme Inhibitors; D008024:Ligands; D002772:Cholera Toxin