Fast, hungry and unstable: finding the Achilles' heel of small-cell lung cancer.
Over 95% of patients with small-cell lung cancer (SCLC) die within five years of diagnosis. The standard of care and the dismal prognosis for this disease have not changed significantly over the past 25 years. Some of the characteristics of SCLC that have defined it as a particularly virulent form of cancer -- rapid proliferation, excessive metabolic and angiogenic dependence, apoptotic imbalance and genetic instability -- are now being pursued as tumor-specific targets for intervention both in preclinical and early phase clinical studies. Here, we summarize areas of ongoing anti-cancer drug development, including classes of agents that target essential pathways regulating proliferation, angiogenesis, apoptotic resistance, chromosomal and protein stability, and cell-cell and cell-matrix interaction.
Hann
Christine L
CL
Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University Cancer Research, Building 2, Baltimore, MD 21231, USA.
Rudin
Charles M
CM
D018288:Carcinoma, Small Cell / Q000235:genetics / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*; D049109:Cell Proliferation; D002470:Cell Survival; D043171:Chromosomal Instability; D006133:Growth Substances / Q000235:genetics / Q000502:physiology; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*; D009154:Mutation; D009389:Neovascularization, Pathologic; D017510:Protein Folding; D015398:Signal Transduction
D006133:Growth Substances