Plasma levels of uridine correlate with blood pressure and indicators of myogenic purine degradation and insulin resistance in hypertensive patients.
BACKGROUND
The relationship between plasma uridine levels and blood pressure (BP), and indicators of muscular purine degradation and insulin resistance (IR) has been evaluated in hypertensive (HT) patients.


RESULTS
In 36 HT patients and 10 normotensive subjects, seated BP was measured, and blood samples were drawn after overnight fast. In 18 of the HT patients, the semi-ischemic forearm test was performed to examine the release of hypoxanthine, ammonium and lactate. Plasma uridine levels were significantly higher than in the normotensive subjects. Fasting plasma insulin levels and homeostasis model assessment of IR correlated with plasma uridine levels in the HT patients. Plasma uridine levels showed a significant correlation with hypoxanthine, ammonia and lactate released from the semi-ischemic exercising muscles of the HT patients.


CONCLUSIONS
Taken together with the positive correlation with indicators of IR, it is suggested that plasma uridine levels in HT are responsible for purine degradation and IR in skeletal muscles.
Hamada
Toshihiro
T
Department of Cardiovascular Medicine, Graduate School of Medical Science, Tottori University, Yonago, Japan. thammer@chukai.ne.jp
Mizuta
Einosuke
E
Yanagihara
Kiyotaka
K
Kaetsu
Yasuhiro
Y
Sugihara
Shinobu
S
Sonoyama
Kazuhiko
K
Yamamoto
Yasutaka
Y
Kato
Masahiko
M
Igawa
Osamu
O
Shigemasa
Chiaki
C
Inokuchi
Taku
T
Yamamoto
Tetsuya
T
Shimada
Toshio
T
Ohtahara
Akira
A
Ninomiya
Haruaki
H
Hisatome
Ichiro
I
D000641:Ammonia / Q000378:metabolism; D001794:Blood Pressure; D016022:Case-Control Studies; D015444:Exercise; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000378:metabolism*; D019271:Hypoxanthine / Q000378:metabolism; D007333:Insulin Resistance; D007511:Ischemia / Q000378:metabolism; D019344:Lactic Acid / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000378:metabolism*; D011687:Purines / Q000378:metabolism*; D014529:Uridine / Q000097:blood*
D011687:Purines; D019271:Hypoxanthine; D019344:Lactic Acid; D000641:Ammonia; D014529:Uridine