Neopeltolide, a macrolide from a lithistid sponge of the family Neopeltidae.
A new marine-derived macrolide designated as neopeltolide (1) has been isolated from a deep-water sponge of the family Neopeltidae. Its structure was elucidated on the basis of spectroscopic data interpretation. Neopeltolide (1) is a potent inhibitor of the in vitro proliferation of the A-549 human lung adenocarcinoma, the NCI-ADR-RES human ovarian sarcoma, and the P388 murine leukemia cell lines, with IC50's of 1.2, 5.1, and 0.56 nM, respectively. Neopeltolide (1) also inhibited the growth of the fungal pathogen Candida albicans with a minimum inhibitory concentration of 0.62 microg/mL.
Wright
Amy E
AE
Center for Ocean Exploration, Biomedical Marine Research Program, Harbor Branch Oceanographic Institution, Inc., 5600 US 1 North, Ft. Pierce, FL 34946, USA. wright@hboi.edu
Botelho
Julianne Cook
JC
Guzmán
Esther
E
Harmody
Dedra
D
Linley
Patricia
P
McCarthy
Peter J
PJ
Pitts
Tara P
TP
Pomponi
Shirley A
SA
Reed
John K
JK
D000818:Animals; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020128:Inhibitory Concentration 50; D007941:Leukemia P388; D018942:Macrolides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D011161:Porifera / Q000737:chemistry* / Q000145:classification; D014407:Tumor Cells, Cultured
D000935:Antifungal Agents; D000970:Antineoplastic Agents; D018942:Macrolides; C519136:neopeltolide