[Gene therapy for Parkinson's disease].
Parkinson's disease is a chronic and progressive disorder whose treatment does not prevent middle term appearance of invalidating motor and psychic complications. Gene therapy techniques which are increasingly applied in the field of neurodegenerative diseases are added to the possibility of treatment of this disease. Among the existing modalities, the in vivo strategies that use potent viral vectors are those which have obtained the best results in the different existing models of the disease. This article aims to review the information regarding the use of these latter techniques, the therapeutic trials that have been conducted and the advantages and disadvantages that the use of the different vectors have.
Gómez Gallego
M
M
Servicio de Neurología, Hospital Universitario Virgen de la Arritxaca, Murcia, Spain. mgomezg@um.es
Fernández Barreiro
A
A
D015316:Genetic Therapy / Q000379:methods; D006801:Humans; D010300:Parkinson Disease / Q000628:therapy*; D014780:Viruses