title: Gender dimorphism in the DAT1 -67 T-allele homozygosity and predisposition to bipolar disorder.
abstract: Linkage and association studies implicate the dopamine transporter gene (DAT1) in the etiopathophysiology of bipolar disorder. We have recently reported the association between the DAT1 core promoter -67A/T polymorphism and this disorder in a sample of Iranian patients. For the first time, these data support sex dimorphism in the homozygosity for the -67 T-allele between male and female affected cases. The present study was undertaken with a larger sample size of cases (N=240) and controls (N=213) to determine whether there is consistent difference between male and female patients and homozygosity for this allele. The results confirm and strengthen our preliminary observation that homozygosity for the T-allele is a predisposing factor in male patients, but not in females (chi2=8.825, df=1, p=0.003). Moreover, Hardy-Weinberg disequilibrium was observed in the female cases studied (chi2=12.9, df=1, p=0.0003), which may reflect the underlying biology. These findings imply gender dimorphism with respect to the DAT1 -67 alleles and susceptibility to disease.
authors.affiliation: Genetics Research Center, University of Social Welfare and Rehabilitation Sciences, Evin, Tehran, Iran. mohadi@uswr.ac.ir
authors.forename: Mina
authors.initials: M
authors.lastname: Ohadi
authors.forename: Mohammad R
authors.initials: MR
authors.lastname: Keikhaee
authors.forename: Arash
authors.initials: A
authors.lastname: Javanbakht
authors.forename: Mohammad R
authors.initials: MR
authors.lastname: Sargolzaee
authors.forename: Mazinani
authors.initials: M
authors.lastname: Robabeh
authors.forename: Hossein
authors.initials: H
authors.lastname: Najmabadi
mesh_terms: D000328:Adult; D000483:Alleles; D001714:Bipolar Disorder / Q000235:genetics*; D002688:Chitinases; D050483:Dopamine Plasma Membrane Transport Proteins / Q000235:genetics*; D029721:Drosophila Proteins; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006023:Glycoproteins; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic / Q000235:genetics; D012727:Sex Characteristics
chemical_list: D050483:Dopamine Plasma Membrane Transport Proteins; D029721:Drosophila Proteins; D006023:Glycoproteins; C493214:SLC6A3 protein, human; D002688:Chitinases; C092318:Idgf6 protein, Drosophila