title: Proposals for standardized protocols for cytogenetic analyses of acute leukemias, chronic lymphocytic leukemia, chronic myeloid leukemia, chronic myeloproliferative disorders, and myelodysplastic syndromes.
abstract: The impact of cytogenetic characterization based on chromosome banding analyses and fluorescence in situ hybridization on clinical decision making has increased dramatically during recent years. Therefore, laboratory techniques have to be optimized to provide reliable results for optimal patient care. In addition, quick and correct results save time and money by preventing unnecessary additional diagnostics and suboptimal treatment approaches. It was our aim to present proposals for standardized protocols to improve the diagnosis, and hence the treatment outcome, of hematologic malignancies.
authors.affiliation: MLL Munich Leukemia Laboratory, Munich, Germany. claudia.haferlach@mll-online.com
authors.forename: Claudia
authors.initials: C
authors.lastname: Haferlach
authors.forename: Harald
authors.initials: H
authors.lastname: Rieder
authors.forename: Debra M
authors.initials: DM
authors.lastname: Lillington
authors.forename: Nicole
authors.initials: N
authors.lastname: Dastugue
authors.forename: Anne
authors.initials: A
authors.lastname: Hagemeijer
authors.forename: Jochen
authors.initials: J
authors.lastname: Harbott
authors.forename: Stephan
authors.initials: S
authors.lastname: Stilgenbauer
authors.forename: Sakari
authors.initials: S
authors.lastname: Knuutila
authors.forename: Bertil
authors.initials: B
authors.lastname: Johansson
authors.forename: Christa
authors.initials: C
authors.lastname: Fonatsch
mesh_terms: D000208:Acute Disease; D002869:Chromosome Aberrations; D020732:Cytogenetic Analysis / Q000379:methods*; D003937:Diagnosis, Differential; D006801:Humans; D007621:Karyotyping; D007938:Leukemia / Q000175:diagnosis / Q000235:genetics*; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000175:diagnosis / Q000235:genetics*; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000175:diagnosis / Q000235:genetics*; D009190:Myelodysplastic Syndromes / Q000175:diagnosis / Q000235:genetics*; D009196:Myeloproliferative Disorders / Q000175:diagnosis / Q000235:genetics*