title: Nasal tip necrosis--an unusual presentation of rheumatoid vasculitis.
abstract: We describe an unusual case of cutaneous necrosis of the nasal tip presenting to a facial reconstructive surgeon. The patient had developed this painless necrosis over a period of about 10 days. Her past medical history included rheumatoid arthritis. She described an exacerbation of her arthritic symptoms in the weeks preceding the development of the nasal tip necrosis. Her rheumatoid arthritis had been managed with corticosteroid and immunosuppressive therapy for more than 3 years. She had not previously experienced extra-articular manifestations (EAMs). A biopsy was taken and histological analysis identified a lymphocytic vasculitis. She was referred to her rheumatologist, and surgical management of her necrotic nasal tip commenced.
authors.affiliation: Clinical Research, Plastic and Reconstructive Surgery, Chelsea and Westminster Hospital, 369 Fulham Road, London, SW10 9NH, UK. graemeglass@hotmail.com
authors.forename: G E
authors.initials: GE
authors.lastname: Glass
authors.forename: A V
authors.initials: AV
authors.lastname: Greig
authors.forename: J
authors.initials: J
authors.lastname: Weir
authors.forename: N
authors.initials: N
authors.lastname: Waterhouse
mesh_terms: D000368:Aged; D001172:Arthritis, Rheumatoid / Q000175:diagnosis* / Q000473:pathology* / Q000628:therapy; D001706:Biopsy; D005260:Female; D006801:Humans; D009336:Necrosis; D009666:Nose / Q000473:pathology; D009668:Nose Diseases / Q000175:diagnosis* / Q000473:pathology* / Q000628:therapy; D017445:Skin Diseases, Vascular / Q000175:diagnosis / Q000628:therapy; D016896:Treatment Outcome; D014657:Vasculitis; D018366:Vasculitis, Leukocytoclastic, Cutaneous / Q000175:diagnosis* / Q000473:pathology* / Q000628:therapy