[Effect of bone morphogenetic proteins-2 on mandibular distraction osteogenesis in rabbits].
OBJECTIVE
To investigate the Effect of recombinant adenovirus vectors containing human Bone morphogenetic proteins-2 (Ad-hBMP-2) on the for mandibular distraction osteogenesis (DO) in rabbits.


METHODS
Twenty-four New Zealand white rabbits were randomly divided into experimental group, and control group and underwent mandibular distraction osteogenesis. After 5 days latency, the distracters were activated at a speed of 0.5 mm every 12 hours for 7 days, then on the first day in the consolidation period, the distraction gaps of experimental group were injected with 0.2 ml Ad-hBMP2 10(12) pfu/L, while the animals of control group were injected with 0.2 ml Ad-EGFP 10(12) pfu/L. At the 7 th and 28 th day of consolidation period, specimens were obtained, X-ray and histomorphology were performed. The bone density and the quantity of new bone formation in the distraction gaps were observed and compared between the two groups at different consolidation period.


RESULTS
Ad-hBMP-2 treated specimens demonstrated an increased amount of new bone formation


CONCLUSIONS
Adenovirally-mediated delivery of BMP-2 can locally increase bone deposition during DO, which may potentially shorten the consolidation period.
Chen
An-wei
AW
Department of Oral and Maxillofacial Surgery, Qilu Hospital of Shandong University, Jinan Shandong 250012, China. chenanwei0822@163.com
Wei
Feng-cai
FC
Wang
Ke-tao
KT
Sun
Shan-zhen
SZ
Liu
Shao-hua
SH
D000818:Animals; D055396:Bone Morphogenetic Protein 2 / Q000494:pharmacology*; D001861:Bone Regeneration / Q000187:drug effects / Q000502:physiology; D006801:Humans; D008297:Male; D008334:Mandible / Q000187:drug effects* / Q000601:surgery; D010012:Osteogenesis / Q000187:drug effects* / Q000502:physiology; D019857:Osteogenesis, Distraction; D011817:Rabbits; D011994:Recombinant Proteins / Q000494:pharmacology*
C525718:BMP2 protein, human; D055396:Bone Morphogenetic Protein 2; D011994:Recombinant Proteins