title: Left ventricular function in male patients with secondary hypogonadism.
abstract: BACKGROUND
  In addition to the effects on ventricular repolarization, testosterone could also affect left ventricular performance. The enhancement of left ventricular contractility in testosterone-deficient rats following testosterone replacement implies to the possible testosterone effect.
  
  
  OBJECTIVE
  The aim of the current study is to reveal the alterations of left ventricular functions, if any, in secondary hypogonadal male patients.
  
  
  METHODS
  Thirty-four males with secondary hypogonadism comprised the study group. The control group consisted of 30 healthy subjects. Echocardiographic measurements including left ventricular dimensions, ejection fraction, mitral inflow, and left ventricular outflow parameters were obtained from all subjects. Tissue Doppler parameters were also measured from left ventricular lateral wall and interventricular septum.
  
  
  RESULTS
  Left ventricular diameters, wall thicknesses, and performance parameters were similar in both groups. Mitral inflow parameters showed a statistically insignificant difference. Pulse-wave tissue Doppler interpretation of hypogonadal and healthy subjects were similar in terms of lateral and septal basal segment Sm, Em, and Am wave velocities.
  
  
  CONCLUSIONS
  Regarding the findings of previous studies that showed impaired myocardial contractility and lusitropy in testosterone deficient rats and our study results, further studies are needed for better understanding of testosterone's effects on human myocardium.
authors.affiliation: Department of Cardiology, Gulhane Military Medical Academy, Ankara, Turkey. obenbaysan@gmail.com
authors.forename: Oben
authors.initials: O
authors.lastname: Baysan
authors.forename: Erol
authors.initials: E
authors.lastname: Bolu
authors.forename: Mehmet
authors.initials: M
authors.lastname: Uzun
authors.forename: Fethi
authors.initials: F
authors.lastname: Kilicaslan
authors.forename: Kursad
authors.initials: K
authors.lastname: Erinc
authors.forename: Murat
authors.initials: M
authors.lastname: Pinar
authors.forename: Adnan
authors.initials: A
authors.lastname: Hasimi
authors.forename: Mehmet
authors.initials: M
authors.lastname: Yokusoglu
authors.forename: Celal
authors.initials: C
authors.lastname: Genc
authors.forename: Pridhvi
authors.initials: P
authors.lastname: Yelamanchili
authors.forename: Hayrettin
authors.initials: H
authors.lastname: Karaeren
authors.forename: Ersoy
authors.initials: E
authors.lastname: Isik
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D018619:Echocardiography, Doppler, Pulsed; D006801:Humans; D007006:Hypogonadism / Q000150:complications*; D008297:Male; D012044:Regression Analysis; D018709:Statistics, Nonparametric; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging* / Q000209:etiology*