Transient neonatal hypothyroidism is associated with elevated serum anti-thyroglobulin antibody levels in newborns and their mothers.
Transient congenital hypothyroidism (TCH) was detected in 6 of 35,067 newborns (1:5845 births) screened in Iran. Antithyroglobulin antibodies positivity was present in 4 of 6 (66.7%) of those with TCH and in 6 of 106 (5.7%) of those with "transient hyperthyrotropinemia and normal" diagnoses (P = .0005), but positivity was similar in newborns with transient hyperthyrotropinemia versus normal neonates (P = .397).
Ordookhani
Arash
A
Endocrine Research Center, Shaheed Beheshti University of Medical Sciences, Tehran, Iran. arash_ordookhani@yahoo.com
Mirmiran
Parvin
P
Walfish
Paul G
PG
Azizi
Fereidoun
F
D000328:Adult; D001323:Autoantibodies / Q000097:blood*; D015331:Cohort Studies; D003409:Congenital Hypothyroidism / Q000175:diagnosis* / Q000453:epidemiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D008297:Male; D015997:Neonatal Screening; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis / Q000276:immunology*; D011336:Probability; D011989:Receptors, Thyrotropin / Q000097:blood; D018570:Risk Assessment; D018709:Statistics, Nonparametric; D013960:Thyroid Function Tests
D001323:Autoantibodies; D011989:Receptors, Thyrotropin; C006606:anti-thyroglobulin