Chromosomal aberrations level in peripheral blood lymphocytes of women with polycystic ovary syndrome.
OBJECTIVE
Polycystic ovary syndrome (PCOS), characterized by polycystic ovaries, hyperandrogenism, chronic anovulation and hirsutism, is a common endocrine disease in females worldwide. Many investigations have shown oxidative stress in such patients and the relationship between genetic instability and oxidative stress is well known. The aim of the present study was to investigate the background chromosomal aberrations (CAs) level in lymphocytes of females with PCOS.


METHODS
Fifteen females, diagnosed with PCOS (hirsutism score >6; significantly increased level of testosterone in blood; increased ovarian volume) and 15 healthy women of similar physical parameters (controls) were included in this investigation. The frequency of CAs in cultures lymphocytes was used as a biomarker of cytogenetic damage.


RESULTS
The frequencies of all types of CAs were significantly higher in patients with PCOS, and the mitotic index was significantly lower.


CONCLUSIONS
Females with PCOS have increased CAs level in lymphocytes which is a sign of genetic instability.
Nersesyan
A
A
National Center of Oncology, Yerevan, Republic of Armenia. armen.nersesyan@meduniwien.ac.at
Martirosyan
A
A
Parsadanyan
G
G
Zalinyan
G
G
D000328:Adult; D016022:Case-Control Studies; D002869:Chromosome Aberrations; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000473:pathology*; D008940:Mitotic Index; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000235:genetics*