Peptide translocators with engineered dehydration-prone hydrogen bonds.
The unfavorable crossing of cell membranes by water-soluble peptides poses a challenge to peptide-based drug delivery. Thus the authors engineered a conformational switch that modulates cellular translocation. The peptide design hinges on dehydration propensities of hydrogen bonds that form to mitigate polar-group internalization penalties and is experimentally corroborated through cell-internalization assays.
Maddipati
Sridhar
S
School of Chemical Engineering, Purdue University, West Lafayette, Indiana 47906, USA.
Fernández
Ariel
A
D001692:Biological Transport; D002462:Cell Membrane / Q000737:chemistry; D003198:Computer Simulation; D016503:Drug Delivery Systems; D006860:Hydrogen Bonding; D008962:Models, Theoretical; D010455:Peptides / Q000737:chemistry*; D017510:Protein Folding
D010455:Peptides