Carbamidocyclophanes A-E, chlorinated paracyclophanes with cytotoxic and antibiotic activity from the Vietnamese cyanobacterium Nostoc sp.
Five new paracyclophanes, carbamidocyclophanes A-E (1-5), characterized by carbamido side chains at a symmetric [7.7]paracyclophane ring, have been isolated from the biomass of the Vietnamese Nostoc sp. CAVN 10. Structure elucidation by spectroscopic methods showed that 1-5 vary in the substitution pattern of the chlorinated butyl side chains. The compounds exhibited cytotoxic activity against MCF-7 (breast cancer cell line) and Fl cells (human amniotic epithelial cell line) and moderate antibacterial activity against the Gram-positive bacterium Staphylococcus aureus.
Bui
Ha T N
HT
Institute of Pharmacy, Ernst-Moritz-Arndt-University, Friedrich-Ludwig-Jahnstrasse 17, D-17487 Greifswald, Germany.
Jansen
Rolf
R
Pham
Hang T L
HT
Mundt
Sabine
S
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006801:Humans; D006843:Hydrocarbons, Chlorinated / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D046937:Nostoc / Q000737:chemistry*; D011083:Polycyclic Compounds / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects; D014407:Tumor Cells, Cultured; D014744:Vietnam
D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D006843:Hydrocarbons, Chlorinated; D011083:Polycyclic Compounds