title: Severe anaphylactic reaction to human insulin in a diabetic patient.
abstract: A 46-year-old nonatopic woman who had been suffering from type 2 diabetes for 17 years was hospitalized at the Endocrinology Department of Selcuk University due to very high glucose levels after recovery from acute hepatitis A infection. She had never used insulin before. After first subcutaneous dose of human regular insulin, severe local allergic reaction developed. Desensitization to insulin was tried. One day later, ketoacidosis developed. Human regular insulin was again subcutaneously injected to the patient. Severe anaphylactic reaction occurred, and in spite of all the medical attempts to save the patient, she died.
authors.affiliation: Division of Endocrinology and Metabolism, Department of Internal Medicine, Meram Medical Faculty, Selcuk University, Konya, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Kaya
authors.forename: Kagan
authors.initials: K
authors.lastname: Gungor
authors.forename: Serdar
authors.initials: S
authors.lastname: Karakose
mesh_terms: D000707:Anaphylaxis / Q000139:chemically induced*; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy*; D016883:Diabetic Ketoacidosis / Q000139:chemically induced*; D004342:Drug Hypersensitivity / Q000209:etiology; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007279:Injections, Subcutaneous; D007328:Insulin / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D008875:Middle Aged
chemical_list: D007328:Insulin