title: Relationship between left ventricle geometric patterns and lymphocyte DNA damage in patients with untreated essential hypertension.
abstract: OBJECTIVE
  To investigate the association between different the left ventricle (LV) geometric patterns and lymphocyte DNA damage in patients with hypertension (HT).
  
  
  METHODS
  We studied 84 patients (50.0+/-6.1, years) with HT and 24 healthy control subjects (48.6+/-3.3, years). Four different geometric patterns were identified in patients according to LV mass index and relative wall thickness. Peripheral lymphocyte DNA damages and plasma levels of total antioxidant status (TAS) were determined in all subjects.
  
  
  RESULTS
  DNA damage was increased in hypertensive patients compared with control group (p=0.001). The major increase in DNA damage was observed in concentric hypertrophic geometric pattern compared with all other geometric patterns (p<0.001, for all). In multiple linear regression analysis, lymphocyte DNA damage was independently correlated with only TAS (beta=-0.444, p<0.001), but not LV geometry (p>0.05).
  
  
  CONCLUSIONS
  The major increase in lymphocyte DNA damage was observed in concentric hypertrophic geometric pattern. This result may be related to increased oxidative stress.
authors.affiliation: Harran University, Faculty of Medicine, Department of Cardiology, Sanliurfa, Turkey. drmugur@yahoo.com
authors.forename: Mustafa
authors.initials: M
authors.lastname: Gur
authors.forename: Ali
authors.initials: A
authors.lastname: Yildiz
authors.forename: Recep
authors.initials: R
authors.lastname: Demirbag
authors.forename: Remzi
authors.initials: R
authors.lastname: Yilmaz
authors.forename: Abdurrahim
authors.initials: A
authors.lastname: Koçyigit
authors.forename: Hakim
authors.initials: H
authors.lastname: Celik
authors.forename: Nurten
authors.initials: N
authors.lastname: Aksoy
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D000975:Antioxidants / Q000378:metabolism; D002784:Cholesterol / Q000097:blood; D020552:Comet Assay; D004249:DNA Damage; D004452:Echocardiography; D005260:Female; D006352:Heart Ventricles / Q000473:pathology; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000235:genetics / Q000473:pathology*; D016014:Linear Models; D008075:Lipoproteins, HDL / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood; D008214:Lymphocytes / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000473:pathology*; D014280:Triglycerides / Q000097:blood
chemical_list: D000975:Antioxidants; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D014280:Triglycerides; D002784:Cholesterol