title: A case of oxaliplatin-related posterior reversible encephalopathy syndrome.
abstract: We report the first case of oxaliplatin-related posterior reversible encephalopathy syndrome (PRES) in the medical literature. A 19-year-old woman with metastatic adenocarcinoma of the rectum received modified FOLFOX (5-fluorouracil/oxaliplatin) chemotherapy. Ten days after the fourth treatment, she presented to the hospital with seizures and altered mental status. Magnetic resonance imaging of the brain demonstrated hyperintensity in the white matter of the posterior hemispheres consistent with PRES. Herein, we briefly review the PRES syndrome and its management.
authors.affiliation: Division of Hematology and Oncology, University of North Carolina at Chapel Hill, NC 27599-7305, USA.
authors.forename: Matthew R
authors.initials: MR
authors.lastname: Skelton
authors.forename: Richard M
authors.initials: RM
authors.lastname: Goldberg
authors.forename: Bert H
authors.initials: BH
authors.lastname: O'Neil
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects*; D001927:Brain Diseases / Q000139:chemically induced*; D005260:Female; D006801:Humans; D009944:Organoplatinum Compounds / Q000009:adverse effects*; D000077150:Oxaliplatin; D012004:Rectal Neoplasms / Q000188:drug therapy*; D013577:Syndrome
chemical_list: D000970:Antineoplastic Agents; D009944:Organoplatinum Compounds; D000077150:Oxaliplatin