(S)-(-)-alpha,alpha-Di(2-naphthyl)-2-pyrrolidinemethanol, a useful tool to study the recognition mechanism in chiral ligand-exchange chromatography.
A dynamic coating of the RP-18 carbon chain layers with the new chiral selector (S)-(-)-alpha,alpha-di(2-naphthyl)-2-pyrrolidinemethanol allowed the formation of a mixed chiral stationary phase that has been used in the separation of a selected set of amino acid racemates. Both a representative model and classification structure-property relationship studies have been performed in order to study the contribution of hydrophobic, bulky and electron-donating groups in the side chain of the chiral selector to the mechanism of chiral recognition.
Natalini
Benedetto
B
Dipartimento di Chimica e Tecnologia del Farmaco, Università degli Studi di Perugia, Perugia, Italy. natalini@chimfarm.unipg.it
Sardella
Roccaldo
R
Macchiarulo
Antonio
A
Natalini
Serena
S
Pellicciari
Roberto
R
D000596:Amino Acids / Q000032:analysis / Q000302:isolation & purification; D019905:Benzyl Alcohol / Q000032:analysis; D001710:Biotin / Q000032:analysis; D002853:Chromatography, Liquid; D000432:Methanol / Q000031:analogs & derivatives*; D010071:Oxaloacetates / Q000032:analysis; D011759:Pyrrolidines
D000596:Amino Acids; D010071:Oxaloacetates; D011759:Pyrrolidines; D001710:Biotin; D019905:Benzyl Alcohol; D000432:Methanol