title: T-cell recognition of Paracoccidioides brasiliensis gp43-derived peptides in patients with paracoccidioidomycosis and healthy individuals.
abstract: Vaccines with synthetic peptides induce the immune response to epitopes that bind to several HLA alleles. By using a TEPITOPE algorithm, we selected and analyzed the T-cell responses of peripheral blood mononuclear cells from 29 paracoccidioidomycosis (PCM) patients to peptides of the immunodominant gp43 antigen of Paracoccidioides brasiliensis, the causative agent of PCM.
authors.affiliation: Laboratory of Immunolgoy, Heart Institute (InCor), Millenium Institutes, São Paulo, Brazil.
authors.forename: Leo Kei
authors.initials: LK
authors.lastname: Iwai
authors.forename: Márcia
authors.initials: M
authors.lastname: Yoshida
authors.forename: Aya
authors.initials: A
authors.lastname: Sadahiro
authors.forename: Washington Robert
authors.initials: WR
authors.lastname: da Silva
authors.forename: Maria Lucia
authors.initials: ML
authors.lastname: Marin
authors.forename: Anna Carla
authors.initials: AC
authors.lastname: Goldberg
authors.forename: Maria Aparecida
authors.initials: MA
authors.lastname: Juliano
authors.forename: Luiz
authors.initials: L
authors.lastname: Juliano
authors.forename: Maria Aparecida
authors.initials: MA
authors.lastname: Shikanai-Yasuda
authors.forename: Jorge
authors.initials: J
authors.lastname: Kalil
authors.forename: Edecio
authors.initials: E
authors.lastname: Cunha-Neto
authors.forename: Luiz R
authors.initials: LR
authors.lastname: Travassos
mesh_terms: D000946:Antigens, Fungal / Q000276:immunology*; D002478:Cells, Cultured; D005656:Fungal Proteins / Q000276:immunology*; D006023:Glycoproteins / Q000276:immunology*; D006801:Humans; D010228:Paracoccidioides / Q000276:immunology*; D010229:Paracoccidioidomycosis / Q000276:immunology* / Q000382:microbiology; D010455:Peptides / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology* / Q000382:microbiology
chemical_list: C103180:43 kDa protein, Paracoccidioides; D000946:Antigens, Fungal; D005656:Fungal Proteins; D006023:Glycoproteins; D010455:Peptides