title: Moderation of the platelet releasate response by aspirin.
abstract: Modulation of the proteins released during activation is one mechanism whereby aspirin may influence platelet-mediated human disease. We investigated the effect of aspirin on the platelet releasate using mass spectrometry and found that different agonists evoked different releasate profiles, with aspirin having a general moderating effect on the amount of protein released regardless of the agonist. These observations were confirmed for several cytokines using an antibody array approach.
authors.affiliation: Department of Cell Biology, Scripps Research Institute, La Jolla, CA, USA.
authors.forename: Judith A
authors.initials: JA
authors.lastname: Coppinger
authors.forename: Roisin
authors.initials: R
authors.lastname: O'Connor
authors.forename: Kieran
authors.initials: K
authors.lastname: Wynne
authors.forename: Michelle
authors.initials: M
authors.lastname: Flanagan
authors.forename: Matthew
authors.initials: M
authors.lastname: Sullivan
authors.forename: Patricia B
authors.initials: PB
authors.lastname: Maguire
authors.forename: Desmond J
authors.initials: DJ
authors.lastname: Fitzgerald
authors.forename: Gerard
authors.initials: G
authors.lastname: Cagney
mesh_terms: D001241:Aspirin / Q000494:pharmacology*; D001792:Blood Platelets / Q000187:drug effects* / Q000378:metabolism*; D003094:Collagen / Q000378:metabolism; D016207:Cytokines / Q000096:biosynthesis; D005786:Gene Expression Regulation; D006801:Humans; D007124:Immunoenzyme Techniques; D007249:Inflammation; D013058:Mass Spectrometry / Q000379:methods; D010974:Platelet Aggregation; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D019699:Thrombospondins / Q000096:biosynthesis; D013929:Thromboxane B2 / Q000096:biosynthesis; D013997:Time Factors
chemical_list: D016207:Cytokines; D010975:Platelet Aggregation Inhibitors; D019699:Thrombospondins; D013929:Thromboxane B2; D003094:Collagen; D001241:Aspirin