title: Reliability of hearing screening in high-risk neonates: comparative study of otoacoustic emission, automated and conventional auditory brainstem response.
abstract: OBJECTIVE
  To compare the diagnostic reliability of automated transient evoked otoacoustic emissions (a-TEOAE), automated auditory brainstem response (a-ABR) and conventional brainstem auditory evoked potential (BAEP/ABR) for identification of hearing loss in high-risk neonates.
  
  
  METHODS
  Two hundred and six neonatal intensive care unit (NICU) admitted neonates were tested pre-discharge. Follow-up included a-TEOAE in all children, repetition of a-ABR or BAEP if failed in NICU. Sensitivity and specificity were compared and correlated with auditory risk factors.
  
  
  RESULTS
  BAEP had the highest sensitivity (100%) and specificity (90.8%), a-ABR the lowest (88.9% and 70.6%). A statistically significant difference in risk factors for temporary hearing loss was observed between normal and false positive a-TEOAE and BAEP, but not a-ABR outcome. Differences in specificity between a-ABR and a-TEOAE explain the pattern of "absent a-ABR/present a-TEOAE" in 13.8% of ears.
  
  
  CONCLUSIONS
  The BAEP appears the more reliable test for hearing screening of high-risk neonates because of highest sensitivity and specificity and should be used to confirm the diagnosis of "auditory neuropathy" in high-risk neonates. The reliability of a-ABR devices in critically ill neonates needs further investigation.
  
  
  CONCLUSIONS
  This is, to our knowledge, the first attempt to compare the diagnostic reliability of a-TEOAE, a-ABR and BAEP in high-risk neonates.
authors.affiliation: Department of Clinical Neurophysiology, Pediatric Hospital, University of Padova, 35100 Padua, Italy. suppiej@pediatria.unipd.it
authors.forename: A
authors.initials: A
authors.lastname: Suppiej
authors.forename: E
authors.initials: E
authors.lastname: Rizzardi
authors.forename: V
authors.initials: V
authors.lastname: Zanardo
authors.forename: M
authors.initials: M
authors.lastname: Franzoi
authors.forename: M
authors.initials: M
authors.lastname: Ermani
authors.forename: E
authors.initials: E
authors.lastname: Orzan
mesh_terms: D016057:Evoked Potentials, Auditory, Brain Stem / Q000502:physiology*; D005260:Female; D005865:Gestational Age; D006309:Hearing / Q000502:physiology*; D006311:Hearing Disorders / Q000175:diagnosis* / Q000503:physiopathology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature / Q000502:physiology*; D007363:Intensive Care Units, Neonatal; D008297:Male; D008403:Mass Screening; D015997:Neonatal Screening; D017084:Otoacoustic Emissions, Spontaneous / Q000502:physiology*; D012680:Sensitivity and Specificity