title: Genetic variation in the renin-angiotensin system and response to endurance training.
abstract: OBJECTIVE
  To investigate the relationship between genetic variation in the renin-angiotensin system and the effect of 12-week endurance training in Korean women.
  
  
  METHODS
  Seventeen women who participated in an endurance training program for 12 weeks were genotyped for the angiotensinogen M235T polymorphism, angiotensin II type 1 receptor A1166C polymorphism, angiotensin-converting enzyme (ACE) T-3892C polymorphism, and angiotensin II type 2 receptor C3123A polymorphism. The following clinical parameters were measured before and after the endurance training program: blood pressure, body composition, ventilatory response, total cholesterol, triglyceride, and glucose.
  
  
  RESULTS
  Of the genetic markers investigated, the frequency of the T allele for the ACE T-3892C polymorphism was significantly associated with the response in body mass index and VO(2max) after 12 weeks of endurance training (p< 0.05). None of the other polymorphisms were significantly associated with the effect of training.
  
  
  CONCLUSIONS
  The significant association between ACE T-3892C and the change in body mass index and VO(2max) in Korean women are attributed to training, suggesting that this genetic variation is a useful genetic marker for clarifying the interindividual response to endurance training.
authors.affiliation: Department of Biochemistry, College of Science, Yonsei University, Seoul, Republic of Korea.
authors.forename: Joon Seol
authors.initials: JS
authors.lastname: Bae
authors.forename: Byung Yong
authors.initials: BY
authors.lastname: Kang
authors.forename: Kang Oh
authors.initials: KO
authors.lastname: Lee
authors.forename: Seung-Taek
authors.initials: ST
authors.lastname: Lee
mesh_terms: D000483:Alleles; D000704:Analysis of Variance; D000886:Anthropometry; D015992:Body Mass Index; D016009:Chi-Square Distribution; D005260:Female; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D007723:Korea; D008875:Middle Aged; D010806:Physical Education and Training; D010807:Physical Endurance; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D012084:Renin-Angiotensin System / Q000235:genetics*