title: Cytokine gene transfer for cancer therapy.
abstract: The possibility of inducing a strong immune response to impair tumor growth by ectopically expressing cytokines, followed by the generation of an antitumor memory raised great hopes and enthusiasm as a therapeutic approach. However, the efficacy of this strategy on established tumor models appeared low and the initial results in the clinics were disappointing. Recently, new evidence indicates that cytokine gene combination or the combined use of cytokine genes with additional gene therapy approaches induces a synergistic effect supporting the use of cytokine gene therapy to improve the clinical outcome for cancer patients.
authors.affiliation: Gene Therapy Laboratory, Instituto Leloir - CONICET, University of Buenos Aires, Av. Patricias Argentinas 435, (C1405BWE) Buenos Aires, Argentina. opodhajcer@leloir.org.ar
authors.forename: Osvaldo L
authors.initials: OL
authors.lastname: Podhajcer
authors.forename: María Verónica
authors.initials: MV
authors.lastname: Lopez
authors.forename: Guillermo
authors.initials: G
authors.lastname: Mazzolini
mesh_terms: D000818:Animals; D016207:Cytokines / Q000235:genetics / Q000276:immunology*; D004195:Disease Models, Animal; D015316:Genetic Therapy; D006801:Humans; D007156:Immunologic Memory / Q000235:genetics; D051379:Mice; D009369:Neoplasms / Q000235:genetics / Q000276:immunology / Q000628:therapy*
chemical_list: D016207:Cytokines