Porin loss and GES-type extended-spectrum beta-lactamase primarily responsible for reduced susceptibility to imipenem.
Lee
Sang Hee
SH
Lee
Jung Hun
JH
Bae
Seung Jin
SJ
Bae
Il Kwon
IK
Jeong
Seok Hoon
SH
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial / Q000502:physiology*; D006801:Humans; D015378:Imipenem / Q000494:pharmacology*; D007710:Klebsiella Infections / Q000188:drug therapy; D007711:Klebsiella pneumoniae / Q000187:drug effects*; D018272:Porins / Q000187:drug effects; D001618:beta-Lactamases / Q000145:classification / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D018272:Porins; D015378:Imipenem; D001618:beta-Lactamases