title: Four novel metabolites from microbial transformation of curcumol by Cunninghamella blakesleana.
abstract: Further study on the microbial transformation of curcumol (1) by Cunninghamella blakesleana (AS3.970) led to the isolation of four novel metabolites. Their structures were elucidated as 3beta-hydroxy curcumol (2), 12-hydroxy curcumol (3), 1alpha-hydroxy-10beta,14-epoxy curcumol (4) and (2S,4S,5S,7S)-10-hydroxymethyl-7-isopropyl-2-methoxy-4-methyl-1-oxaspiro[4,6]undec-10-en-8-one (5) on the basis of spectral methods. All of them were characterized as new compounds.
authors.affiliation: Department of Natural Products Chemistry, Shenyang Pharmaceutical University, Shenyang, P.R.China.
authors.forename: Hui
authors.initials: H
authors.lastname: Zhang
authors.forename: Ning
authors.initials: N
authors.lastname: Kang
authors.forename: Feng
authors.initials: F
authors.lastname: Qiu
authors.forename: Ge-Xia
authors.initials: GX
authors.lastname: Qu
authors.forename: Xin-Sheng
authors.initials: XS
authors.lastname: Yao
mesh_terms: D001711:Biotransformation / Q000502:physiology; D020093:Cunninghamella / Q000378:metabolism*; D015394:Molecular Structure; D012717:Sesquiterpenes / Q000737:chemistry* / Q000378:metabolism*
chemical_list: D012717:Sesquiterpenes; C022801:curcumol