Polymorphic variants of genes encoding main antioxidant enzymes and the risk of CL/P-affected pregnancies.
OBJECTIVE
The study focused on the correlation between maternal polymorphisms of genes encoding antioxidant enzymes and the risk of having a child with CL/P in the Polish population.


METHODS
PCR-RFLP analysis was used to analyze polymorphisms of MnSOD2 (c.47T>C), CAT (c.-330C>T) and GPX1 (c.599C>T) in mothers of children with CL/P and control mothers.


CONCLUSIONS
Polymorphic variants of genes for main antioxidant enzymes were determined not to be a maternal risk factor for having a child with CL/P in the investigated group of women.
Mostowska
Adrianna
A
Department of Biochemistry and Molecular Biology, University of Medical Sciences in Poznan, Swiecickiego St 6, 60-781 Poznan, Poland. amostowska@wp.pl
Hozyasz
Kamil K
KK
Lianeri
Margarita
M
Piwowar
Wlodzimierz
W
Jagodzinski
Pawel P
PP
D000328:Adult; D002374:Catalase / Q000235:genetics; D002971:Cleft Lip / Q000235:genetics*; D002972:Cleft Palate / Q000235:genetics*; D004798:Enzymes / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D005979:Glutathione Peroxidase / Q000235:genetics; D006801:Humans; D007223:Infant; D015810:Linkage Disequilibrium; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D011247:Pregnancy; D013482:Superoxide Dismutase / Q000235:genetics
D004798:Enzymes; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase