title: Early noncardiogenic pulmonary edema and the use of PEEP and prone ventilation after emergency liver transplantation.
abstract: Noncardiogenic pulmonary edema in liver transplant recipients is usually secondary to TRALI (transfusion related acute lung injury) or liver ischemic-reperfusion injury. If persistent, the resultant hypoxemia is associated with increased ventilator days, prolonged length of stay (intensive care and hospital) and increased 28-day mortality. Ventilation strategies for the management of hypoxemia in acute lung injury include moderate to high levels of PEEP (positive and expiratory pressure) and prone ventilation (PV). Such strategies have theoretical adverse effects on graft perfusion. Evidence does however exist to demonstrate that maintenance of cardiac output and correct positioning of the prone patient to allow abdominal excursion can negate the deleterious effects of PEEP and PV. A liver transplant recipient became profoundly hypoxemic on our intensive care unit following the onset of noncardiogenic pulmonary edema. A risk-benefit assessment performed at the time deemed that the potential adverse effects of PEEP and PV were outweighed by the life-threatening nature of hypoxemia. The patient's condition improved following prone positioning and application of PEEP (10-15 cm H(2)O). We conclude that such ventilation strategies are appropriate in hypoxemic liver transplant recipients if an appropriate risk-benefit assessment is performed.
authors.affiliation: Department of Perioperative and Critical Care, Freeman Hospital, Newcastle upon Tyne, United Kingdom.
authors.forename: E
authors.initials: E
authors.lastname: Sykes
authors.forename: J F
authors.initials: JF
authors.lastname: Cosgrove
authors.forename: I D
authors.initials: ID
authors.lastname: Nesbitt
authors.forename: C B
authors.initials: CB
authors.lastname: O'Suilleabhain
mesh_terms: D000328:Adult; D004632:Emergency Medical Services; D005260:Female; D006801:Humans; D000860:Hypoxia / Q000209:etiology; D016031:Liver Transplantation / Q000009:adverse effects*; D011175:Positive-Pressure Respiration / Q000009:adverse effects / Q000379:methods*; D016684:Prone Position; D011654:Pulmonary Edema / Q000209:etiology* / Q000628:therapy*; D012121:Respiration, Artificial / Q000009:adverse effects / Q000379:methods*; D018570:Risk Assessment; D016896:Treatment Outcome