title: Synthesis of the fused polyether core of hemibrevetoxin B by two-directional ring-closing metathesis.
abstract: The tetracyclic fused polyether core of the marine natural product hemibrevetoxin B has been prepared in an efficient manner by using a strategy in which ring-closing metathesis (RCM) reactions were employed for ring synthesis. Simultaneous construction of the A and D rings was accomplished by double two-directional RCM of a tetraene. [reaction: see text]
authors.affiliation: WestCHEM, Department of Chemistry, Joseph Black Building, University of Glasgow, University Avenue, Glasgow G12 8QQ, United Kingdom. stephenc@chem.gla.ac.uk
authors.forename: J Stephen
authors.initials: JS
authors.lastname: Clark
authors.forename: Damian M
authors.initials: DM
authors.lastname: Grainger
authors.forename: Alexandra A-C
authors.initials: AA
authors.lastname: Ehkirch
authors.forename: Alexander J
authors.initials: AJ
authors.lastname: Blake
authors.forename: Claire
authors.initials: C
authors.lastname: Wilson
mesh_terms: D003500:Cyclization; D004987:Ethers / Q000737:chemistry*; D006576:Heterocyclic Compounds, 4 or More Rings / Q000138:chemical synthesis*; D008387:Marine Toxins / Q000138:chemical synthesis*; D008956:Models, Chemical
chemical_list: D004987:Ethers; D006576:Heterocyclic Compounds, 4 or More Rings; D008387:Marine Toxins; C409729:hemibrevetoxin B