Associations of the plasma interleukin 6 (IL-6) levels with disability and mortality in the elderly in the Treviso Longeva (Trelong) study.
IL-6 expression is regulated by the interplay of several transcriptional and hormonal factors, including sex steroids and glucocorticoids. In late life IL-6 expression increases as a result from loss of the normally inhibiting sex steroids. IL-6 is one of several proinflammatory cytokines. It has been proposed that many chronic inflammatory diseases are the result of a dysregulation of IL-6 expression. In this work we demonstrate that increased IL-6 levels in elderly are associated with higher disability and mortality, also independently of age and comorbidity.
Gallucci
M
M
ARGel, Interdisciplinary Geriatric Research Association, Trento Trieste Aven. 19, I-31100 Treviso, Italy. m_gallucci@tin.it <m_gallucci@tin.it>
Amici
G P
GP
Ongaro
F
F
Gajo
G B
GB
De Angeli
S
S
Forloni
G L
GL
Albani
D
D
Prato
F
F
Polito
L
L
Zanardo
A
A
Regini
C
C
D000368:Aged; D000369:Aged, 80 and over; D004185:Disability Evaluation; D005260:Female; D006304:Health Status; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D007558:Italy / Q000453:epidemiology; D008297:Male; D009026:Mortality
D015850:Interleukin-6