A case of acute hepatitis E associated with multidrug hypersensitivity and cytomegalovirus reactivation.
A 65-year-old Japanese man was hospitalized because of acute hepatitis and severe cholestasis due to hepatitis E virus (HEV) infection combined with a drug reaction to a cold preparation. He died of disseminated intravascular coagulation and severe intestinal bleeding due to systemic cytomegalovirus reactivation following the development of severe eruptions with marked eosinophilia due to drug hypersensitivity to taurine and ursodeoxycholate preparations. The close interaction between viral infection or reactivation and drug hypersensitivity was considered as a pathophysiology in this case, which emphasizes the need for further study of the immunological mechanism of the interaction.
Takikawa
Yasuhiro
Y
First Department of Internal Medicine, Iwate Medical University, Morioka, Japan.
Yasumi
Yuki
Y
Sato
Akihiro
A
Endo
Ryujin
R
Suzuki
Kazuyuki
K
Mori
Yasuki
Y
Akasaka
Hidetoshi
H
Miura
Yasuhiro
Y
Sawai
Takashi
T
Okamoto
Hiroaki
H