title: Family history of cancer in children with acute leukemia, Hodgkin's lymphoma or non-Hodgkin's lymphoma: the ESCALE study (SFCE).
abstract: The role of a family history of cancer in the etiology of childhood hematopoietic malignancies was investigated using the data from the ESCALE study. ESCALE, a population-based case-control study, was carried out in France over the period, 2003-2004. A total of 773 cases of acute leukemia (AL), 130 of Hodgkin's lymphoma (HL), 163 of non-Hodgkin's lymphoma (NHL) and 1,681 population-based controls were included. The controls were randomly selected from the French population and were frequency matched with the cases on age and gender. Cancer history in first- and second-degree relatives was reported by the mothers in a structured telephone questionnaire that was the same for the cases and controls. Odds ratios (ORs) were estimated using an unconditional regression model taking into account the stratification variables and potential confounders. A family history of cancer was associated with an increased risk of HL (OR = 1.5 [1.0-2.2]) and NHL (OR = 1.8 [1.3-2.5]), but not AL (OR = 1.0 [0.9-1.2]). The ORs were higher when at least 2 relatives had a history of cancer or when 1 case occurred before age 46 years. Only HL was significantly associated with a family history of hematopoietic malignancies (OR = 2.0 [1.0-3.8]), mainly because of a significant association with a history of HL (OR = 5.4 [1.3-22]). In conclusion, the study findings support the hypothesis of familial susceptibility to childhood lymphoma, but do not suggest familial susceptibility to childhood AL.
authors.affiliation: INSERM, U754, Villejuif, France. rudant@vjf.inserm.fr
authors.forename: Jérémie
authors.initials: J
authors.lastname: Rudant
authors.forename: Florence
authors.initials: F
authors.lastname: Menegaux
authors.forename: Guy
authors.initials: G
authors.lastname: Leverger
authors.forename: André
authors.initials: A
authors.lastname: Baruchel
authors.forename: Brigitte
authors.initials: B
authors.lastname: Nelken
authors.forename: Yves
authors.initials: Y
authors.lastname: Bertrand
authors.forename: Olivier
authors.initials: O
authors.lastname: Hartmann
authors.forename: Hélène
authors.initials: H
authors.lastname: Pacquement
authors.forename: Cécile
authors.initials: C
authors.lastname: Vérité
authors.forename: Alain
authors.initials: A
authors.lastname: Robert
authors.forename: Gérard
authors.initials: G
authors.lastname: Michel
authors.forename: Geneviève
authors.initials: G
authors.lastname: Margueritte
authors.forename: Virginie
authors.initials: V
authors.lastname: Gandemer
authors.forename: Denis
authors.initials: D
authors.lastname: Hémon
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Clavel
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D004198:Disease Susceptibility / Q000145:classification / Q000453:epidemiology / Q000473:pathology; D005260:Female; D006689:Hodgkin Disease / Q000453:epidemiology* / Q000473:pathology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D015470:Leukemia, Myeloid, Acute / Q000453:epidemiology* / Q000473:pathology; D008228:Lymphoma, Non-Hodgkin / Q000453:epidemiology* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000453:epidemiology* / Q000473:pathology