title: Resistance mutations in subtype C HIV type 1 isolates from Indian patients of Mumbai receiving NRTIs plus NNRTIs and experiencing a treatment failure: resistance to AR.
abstract: We present here the first data available on resistance to nucleoside reverse transcriptase inhibitors (NRTIs) and nonnucleoside reverse transcriptase inhibitors (NNRTIs) in India. In these subtype C isolates, we have observed most of the mutations noted in reverse transcriptase (RT) for subtype B with some additional substitutions (at positions 98, 203, 208, and 221) that will warrant attention in the algorithms used.
authors.affiliation: Grant Medical College and Sir JJ Hospital, Byculla, Mumbai, India.
authors.forename: Alaka
authors.initials: A
authors.lastname: Deshpande
authors.forename: Valérie
authors.initials: V
authors.lastname: Jauvin
authors.forename: Noel
authors.initials: N
authors.lastname: Magnin
authors.forename: Patricia
authors.initials: P
authors.lastname: Pinson
authors.forename: Muriel
authors.initials: M
authors.lastname: Faure
authors.forename: Bernard
authors.initials: B
authors.lastname: Masquelier
authors.forename: Valérie
authors.initials: V
authors.lastname: Aurillac-Lavignolle
authors.forename: Hervé J
authors.initials: HJ
authors.lastname: Fleury
mesh_terms: D023241:Antiretroviral Therapy, Highly Active; D024882:Drug Resistance, Viral / Q000235:genetics*; D015658:HIV Infections / Q000188:drug therapy* / Q000235:genetics; D015497:HIV-1 / Q000145:classification / Q000187:drug effects* / Q000235:genetics; D006801:Humans; D007194:India; D009154:Mutation / Q000235:genetics; D011110:Polymorphism, Genetic / Q000235:genetics; D012194:RNA-Directed DNA Polymerase / Q000235:genetics*; D018894:Reverse Transcriptase Inhibitors / Q000494:pharmacology*; D017211:Treatment Failure
chemical_list: D018894:Reverse Transcriptase Inhibitors; D012194:RNA-Directed DNA Polymerase