Encephalopathy after furosemide use in nephrotic syndrome.
An 18-year-old girl with nephrotic syndrome presented with a life-threatening respiratory failure and a severe encephalopathy, shortly after being started on furosemide. The evaluation confirmed furosemide as the sole culprit for the clinical manifestations. This case highlights an unpredictable dose-response relationship of furosemide. The pathophysiological basis, differential diagnosis and clinical implications of the observed findings are discussed.
Sharma
Ajay P
AP
Department of Pediatrics, University of Western Ontario, London, Ontario, Canada. ajay.sharma@lhsc.on.ca
Grimmer
Joanne
J
D000293:Adolescent; D001921:Brain; D001927:Brain Diseases / Q000175:diagnosis / Q000503:physiopathology; D003937:Diagnosis, Differential; D005260:Female; D005665:Furosemide / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D009404:Nephrotic Syndrome / Q000188:drug therapy*
D005665:Furosemide