title: Development-dependent expression of cyclin D3 in precursor T-cell lymphoblastic leukemia/lymphoma.
abstract: In contrast to the clear oncogenic role of cyclins D1 and D2, cyclin D3 is suggested to have a role in the initiation and/or maintenance of differentiation in a lineage-associated manner in addition to its basic role in proliferation. Recently, it has been reported that in cyclin D3-deficient mice, normal expansion of T lymphocytes is impaired because of maturation arrest at the double-negative thymocyte stage, suggesting a crucial role for cyclin D3 in early T-cell development. Therefore, cyclin D3 expression was examined in 36 human precursor T-lymphoblastic leukemia/lymphomas (T-LBLL), a neoplastic counterpart of T cells at the early developmental stages of differentiation. Using a standard panel of differentiation markers, all T-LBLL were categorized into four stages according to differentiation: progenitor, double-negative, double-positive, and single-positive stages. Cyclin D3 expression was initiated at the boundary between double-negative and double-positive stages, and was sustained in the single-positive stage. T-cell receptor was expressed simultaneously with cyclin D3, whereas CD79a expression was specific in the double-negative stage, and thus it was inversely correlated with that of cyclin D3. Taken together with the crucial and non-redundant role in T-cell development in mice, this molecule is suggested to play an important role in human T-cell development.
authors.affiliation: Department of Pathology and Molecular Diagnostics, Aichi Cancer Center Hospital, Nagoya, Japan.
authors.forename: Eiichi
authors.initials: E
authors.lastname: Sasaki
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Yatabe
authors.forename: Mitsuyoshi
authors.initials: M
authors.lastname: Hashimoto
authors.forename: Yoriko
authors.initials: Y
authors.lastname: Yamashita
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Hasegawa
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kojima
authors.forename: Toshiro
authors.initials: T
authors.lastname: Nagasawa
authors.forename: Naoyoshi
authors.initials: N
authors.lastname: Mori
mesh_terms: D051925:CD79 Antigens / Q000235:genetics / Q000378:metabolism; D002454:Cell Differentiation; D049109:Cell Proliferation; D002471:Cell Transformation, Neoplastic / Q000378:metabolism* / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D056743:Cyclin D3; D016213:Cyclins / Q000235:genetics / Q000378:metabolism*; D018450:Disease Progression; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007223:Infant; D007945:Leukemia, Lymphoid / Q000378:metabolism* / Q000473:pathology; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000378:metabolism* / Q000473:pathology; D011948:Receptors, Antigen, T-Cell / Q000235:genetics / Q000378:metabolism; D013950:Thymus Gland / Q000166:cytology / Q000378:metabolism
chemical_list: C534696:CCND3 protein, human; D051925:CD79 Antigens; C534697:Ccnd3 protein, mouse; D056743:Cyclin D3; D016213:Cyclins; D011948:Receptors, Antigen, T-Cell