title: HIV-1 natural viral suppressors: control of viral replication in the absence of therapy.
abstract: The objective of this study was to identify and define a cohort of HIV-1-infected individuals with the ability to suppress HIV-1 replication naturally (patients with undetectable viral loads for at least 2 years without antiretroviral drugs). Proviral DNA ranged from one to 74 copies/10(6) peripheral blood mononuclear cells, with the mean value lower by 1-2 logs than long-term non-progressors. This ability to control HIV-1 viral replication naturally has led us to refer to them as natural viral suppressors.
authors.affiliation: Institute of Human Virology, University of Maryland, Baltimore, Maryland, USA.
authors.forename: Mohammad M
authors.initials: MM
authors.lastname: Sajadi
authors.forename: Alonso
authors.initials: A
authors.lastname: Heredia
authors.forename: Nhut
authors.initials: N
authors.lastname: Le
authors.forename: Neil T
authors.initials: NT
authors.lastname: Constantine
authors.forename: Robert R
authors.initials: RR
authors.lastname: Redfield
mesh_terms: D015331:Cohort Studies; D004279:DNA, Viral / Q000097:blood; D015658:HIV Infections / Q000821:virology*; D015497:HIV-1 / Q000502:physiology*; D006801:Humans; D011533:Proviruses / Q000502:physiology; D019562:Viral Load; D014779:Virus Replication
chemical_list: D004279:DNA, Viral