[The status of redox system in patients with Graves' disease].
The aim of our investigation was studying the redox processes, the establishment of state of blood oxidative and antioxidant systems in patients with Graves' Disease (GD). 19 with diffuse-toxic goiter have been investigated. Control group included 10 practically healthy subjects. The parameters of blood redox-system were investigated by electron-paramagnetic resonance method (EPR). In GD group hypothyroidism was diagnosed in 7 patients (36,8%), euthyroidism - in 7 patients (36,8%) and hypothyroidism - in 5 (26,3%). The value of ceruloplasmin in main group was significantly higher than in the control (18,6+/-1,3 mm/mg vs. 16,0+/-1,1 mm/mg, p<0,001); EPR-signal of Fe(3+)-transferrin in main group was also significantly higher (19,2+/-1,2 mm/mg vs. 22,0+/-0,9 mm/mg, p<0,001); values of nitric oxide in both groups were almost identical. EPR-signals of Mn(2+) ions significantly correlated with thyroid volume (r=0,5461, p=0,016), NO - with antibodies to thyroglobulin (r=0,5750, p=0,010). These changes demonstrate possible relationship between autoimmune diseases and redox-system.
Virsaladze
D K
DK
Tsotsonava
T A
TA
Khitarishvili
K V
KV
Sanikidze
T V
TV
Tananashvili
D E
DE
D000328:Adult; D000906:Antibodies / Q000276:immunology; D005260:Female; D006111:Graves Disease / Q000175:diagnosis / Q000276:immunology* / Q000503:physiopathology*; D006801:Humans; D007453:Iodide Peroxidase / Q000276:immunology; D008297:Male; D008875:Middle Aged; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000502:physiology*; D012720:Severity of Illness Index; D013954:Thyroglobulin / Q000276:immunology
D000906:Antibodies; D013954:Thyroglobulin; D007453:Iodide Peroxidase