Genetic studies of human diversity in East Asia.
East Asia is one of the most important regions for studying evolution and genetic diversity of human populations. Recognizing the relevance of characterizing the genetic diversity and structure of East Asian populations for understanding their genetic history and designing and interpreting genetic studies of human diseases, in recent years researchers in China have made substantial efforts to collect samples and generate data especially for markers on Y chromosomes and mtDNA. The hallmark of these efforts is the discovery and confirmation of consistent distinction between northern and southern East Asian populations at genetic markers across the genome. With the confirmation of an African origin for East Asian populations and the observation of a dominating impact of the gene flow entering East Asia from the south in early human settlement, interpretation of the north-south division in this context poses the challenge to the field. Other areas of interest that have been studied include the gene flow between East Asia and its neighbouring regions (i.e. Central Asia, the Sub-continent, America and the Pacific Islands), the origin of Sino-Tibetan populations and expansion of the Chinese.
Zhang
Feng
F
Institute of Genetics, School of Life Sciences, Fudan University, Shanghai 200433, People's Republic of China.
Su
Bing
B
Zhang
Ya-ping
YP
Jin
Li
L
D005075:Biological Evolution; D041322:Chromosomes, Human, Y / Q000235:genetics; D004272:DNA, Mitochondrial / Q000235:genetics; D004641:Emigration and Immigration; D005202:Asia, Eastern; D005819:Genetic Markers; D014644:Genetic Variation; D005828:Genetics, Population; D016045:Human Genome Project; D006801:Humans; D011157:Population Dynamics
D004272:DNA, Mitochondrial; D005819:Genetic Markers