title: The paradox of natural products as pharmaceuticals. Experimental evidences of a mango stem bark extract.
abstract: Recent findings regarding basic, pre-clinical and clinical studies on a mango stem bark extract (MSBE) developed in Cuba (Vimang) on an industrial scale are summarized. Ethnomedical studies, extract reproducibility, biological effects and clinical evaluations in terms of patient quality of life are described as experimental evidences to support the statement that natural products, even being a mixture of compounds, could be as effective as "monoceuticals" for medical uses. Discussion about the use of "monoceuticals" versus "natureceuticals" in health care and medicine is based on effectiveness and availability, taking Vimang as an example of a natural product with supported scientific evidence to be used as antioxidant, analgesic, anti-inflammatory and immunomodulator.
authors.affiliation: Center of Pharmaceutical Chemistry, 21 Ave. & 200 St., Atabey, Apdo. 16042, CP 11600 Havana, Cuba. alberto.nunez@cqf.sld.cu
authors.forename: Alberto J
authors.initials: AJ
authors.lastname: Núñez-Sellés
authors.forename: René
authors.initials: R
authors.lastname: Delgado-Hernández
authors.forename: Gabino
authors.initials: G
authors.lastname: Garrido-Garrido
authors.forename: Dagmar
authors.initials: D
authors.lastname: García-Rivera
authors.forename: Mariela
authors.initials: M
authors.lastname: Guevara-García
authors.forename: Gilberto L
authors.initials: GL
authors.lastname: Pardo-Andreu
mesh_terms: D000700:Analgesics / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology*; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D004304:Dosage Forms / Q000592:standards; D004353:Drug Evaluation, Preclinical; D006801:Humans; D007155:Immunologic Factors / Q000737:chemistry / Q000494:pharmacology*; D031022:Mangifera; D024301:Plant Bark; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D011786:Quality Control; D015203:Reproducibility of Results; D013678:Technology, Pharmaceutical / Q000379:methods; D016896:Treatment Outcome
chemical_list: D000700:Analgesics; D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D004304:Dosage Forms; D007155:Immunologic Factors; C501277:Mangifera indica extract; D010936:Plant Extracts