title: Central administration of melanocortin agonist increased insulin sensitivity in diet-induced obese rats.
abstract: In this study, we examined the effects of intracerebroventricular administration of melanotan II (MTII), a melanocortin agonist, on insulin sensitivity in diet-induced obese (DIO) rats. Although MTII treatment significantly decreased food intake and body weight for 10 days, there was no significant difference in body weight between MTII and pair-fed groups. The insulin tolerance test showed that insulin sensitivity was significantly improved in the MTII group compared to the pair-fed group. Furthermore, MTII treatment increased the number of small-sized adipocytes in epididymal white adipose tissues, suggesting that MTII increased insulin sensitivity through action on the white adipose tissues in DIO rats.
authors.affiliation: Department of Endocrinology and Diabetes, Field of Internal Medicine, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan.
authors.forename: Ryoichi
authors.initials: R
authors.lastname: Banno
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Arima
authors.forename: Masayuki
authors.initials: M
authors.lastname: Hayashi
authors.forename: Motomitsu
authors.initials: M
authors.lastname: Goto
authors.forename: Minemori
authors.initials: M
authors.lastname: Watanabe
authors.forename: Ikuko
authors.initials: I
authors.lastname: Sato
authors.forename: Nobuaki
authors.initials: N
authors.lastname: Ozaki
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nagasaki
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Ozaki
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Oiso
mesh_terms: D017667:Adipocytes / Q000166:cytology / Q000187:drug effects; D052436:Adipose Tissue, White / Q000166:cytology / Q000187:drug effects; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D016207:Cytokines / Q000097:blood; D004032:Diet; D004435:Eating / Q000187:drug effects; D007328:Insulin / Q000494:pharmacology*; D007333:Insulin Resistance; D008297:Male; D053486:Melanocortins / Q000819:agonists*; D009765:Obesity; D010456:Peptides, Cyclic / Q000008:administration & dosage*; D051381:Rats; D017207:Rats, Sprague-Dawley; D000521:alpha-MSH / Q000008:administration & dosage / Q000031:analogs & derivatives*
chemical_list: D016207:Cytokines; D007328:Insulin; D053486:Melanocortins; D010456:Peptides, Cyclic; C079282:melanotan-II; D000521:alpha-MSH