title: Lytic and latent antigens of the human gammaherpesviruses Kaposi's sarcoma-associated herpesvirus and Epstein-Barr virus induce T-cell responses with similar functional properties and memory phenotypes.
abstract: The cellular immunity against Kaposi's sarcoma-associated herpesvirus (KSHV) is poorly characterized and has not been compared to T-cell responses against other human herpesviruses. Here, novel and dominant targets of KSHV-specific cellular immunity are identified and compared to T cells specific for lytic and latent antigens in a second human gammaherpesvirus, Epstein-Barr virus. The data identify a novel HLA-B57- and HLA-B58-restricted epitope in the Orf57 protein and show consistently close parallels in immune phenotypes and functional response patterns between cells targeting lytic or latent KSHV- and EBV-encoded antigens, suggesting common mechanisms in the induction of these responses.
authors.affiliation: Partners AIDS Research Center, Massachusetts General Hospital East, 149 13th Street, Charlestown, MA 02129-2000, USA.
authors.forename: Florian
authors.initials: F
authors.lastname: Bihl
authors.forename: Murli
authors.initials: M
authors.lastname: Narayan
authors.forename: John V
authors.initials: JV
authors.lastname: Chisholm
authors.forename: Leah M
authors.initials: LM
authors.lastname: Henry
authors.forename: Todd J
authors.initials: TJ
authors.lastname: Suscovich
authors.forename: Elizabeth E
authors.initials: EE
authors.lastname: Brown
authors.forename: Tania M
authors.initials: TM
authors.lastname: Welzel
authors.forename: Daniel E
authors.initials: DE
authors.lastname: Kaufmann
authors.forename: Tauheed M
authors.initials: TM
authors.lastname: Zaman
authors.forename: Sheila
authors.initials: S
authors.lastname: Dollard
authors.forename: Jeff N
authors.initials: JN
authors.lastname: Martin
authors.forename: Fred
authors.initials: F
authors.lastname: Wang
authors.forename: David T
authors.initials: DT
authors.lastname: Scadden
authors.forename: Kenneth M
authors.initials: KM
authors.lastname: Kaye
authors.forename: Christian
authors.initials: C
authors.lastname: Brander
mesh_terms: D000956:Antigens, Viral / Q000276:immunology*; D000939:Epitopes / Q000235:genetics; D004854:Herpesvirus 4, Human / Q000276:immunology*; D019288:Herpesvirus 8, Human / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular / Q000276:immunology*; D007156:Immunologic Memory / Q000276:immunology; D016130:Immunophenotyping; D013601:T-Lymphocytes / Q000276:immunology* / Q000821:virology; D014764:Viral Proteins / Q000235:genetics
chemical_list: D000956:Antigens, Viral; D000939:Epitopes; D014764:Viral Proteins