Six new triterpenoid saponins from the leaves of Ilex oblonga and their inhibitory activities against TMV replication.
Six new triterpenoid saponins of the ursane types were isolated from the MeOH extract of the leaves of Ilex oblonga. They were oblonganoside A (1), oblonganoside B (2), oblonganoside C (6), oblonganoside D (8), oblonganoside E (9), and oblonganoside F (10), together with three known triterpenoid saponins. The structures of these compounds were elucidated on the basis of spectroscopic analysis, and compound 1 showed appreciable inhibitory activity against TMV replication with EC50 value 0.074 mM.
Wu
Zu-Jian
ZJ
Key Laboratory of Bio-pesticide and Chemistry-Biology, Ministry of Education, Fujian Agriculture and Forestry University, Fuzhou, Fujian, P.R.China.
Ouyang
Ming-An
MA
Wang
Cong-Zhou
CZ
Zhang
Zheng-Kun
ZK
D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology; D030017:Ilex / Q000737:chemistry*; D015394:Molecular Structure; D018515:Plant Leaves / Q000737:chemistry* / Q000821:virology; D012503:Saponins / Q000737:chemistry / Q000494:pharmacology*; D014026:Nicotiana / Q000821:virology; D014027:Tobacco Mosaic Virus / Q000187:drug effects*; D014315:Triterpenes / Q000737:chemistry / Q000494:pharmacology*; D014779:Virus Replication / Q000187:drug effects
D000998:Antiviral Agents; D012503:Saponins; D014315:Triterpenes