title: Serous cystadenoma of the epididymis of common epithelial ovarian type: case report with an immunohistochemical study.
abstract: We report the clinical, morphological and immunohistochemical findings of a case with non-papillary serous cystadenoma of the epididymis. The tumor was a unilocular cyst with a thin fibrous capsule, lined by cuboidal or columnar epithelium containing ciliated cells, mostly arranged in a single layer. Immunohistochemically, the tumor cells were positive for cytokeratin (CK) AE1/AE3 and epithelial membrane antigen (EMA), strongly positive for CK7, progesterone receptor (PR), estrogen receptor (ER), androgen receptor (AR), vimentin, CA-125 and S-100 protein. The cells did not stain for CK20 and CD10. Morphological and immunohistochemical features suggested a mullerian differentiation, possibly originated from vestigial remnants of the Muller duct. This tumor is one of the rare benign lesions which should be considered in the differential diagnosis of a swelling in the epididymal region.
authors.affiliation: Department of Pathology, 3rd Hospital of Social Security Foundation, Athens, Greece.
authors.forename: Th
authors.initials: T
authors.lastname: Klimis
authors.forename: P
authors.initials: P
authors.lastname: Vlahos
authors.forename: N
authors.initials: N
authors.lastname: Kokotas
mesh_terms: D000369:Aged, 80 and over; D018293:Cystadenoma, Serous / Q000378:metabolism / Q000473:pathology*; D004822:Epididymis / Q000378:metabolism / Q000473:pathology*; D005834:Genital Neoplasms, Male / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D009095:Mullerian Ducts / Q000378:metabolism / Q000473:pathology