title: Frequency of CCR5 variants among rural populations with low HIV-1 prevalence in Cameroon.
abstract: Among rural populations in Cameroon, HIV-1 prevalence is low and the genetic diversity broad. An unusual population-level genetic background may modulate this pattern of HIV infection. We examined HIV-1 prevalence, CCR5Delta32 and CCR5 promoter -2459 G genotype frequency among 1390 rural inhabitants. No individual was identified with the CCR5Delta32 allele, but homozygotes for the CCR5 promoter variant -2459G (27.5%) were relatively common. A seroprevalence of 3.1% of HIV-1 was reported.
authors.affiliation: Walter Reed Johns Hopkins Cameroon Program, Yaounde, Cameroon. jtorimiro@hopkinscameroon.org
authors.forename: Judith N
authors.initials: JN
authors.lastname: Torimiro
authors.forename: Nathan D
authors.initials: ND
authors.lastname: Wolfe
authors.forename: Alero
authors.initials: A
authors.lastname: Thomas
authors.forename: Maureen P
authors.initials: MP
authors.lastname: Martin
authors.forename: Eitel
authors.initials: E
authors.lastname: Mpoudi-Ngole
authors.forename: Ubald
authors.initials: U
authors.lastname: Tamoufe
authors.forename: Deborah L
authors.initials: DL
authors.lastname: Birx
authors.forename: Mary
authors.initials: M
authors.lastname: Carrington
authors.forename: Donald S
authors.initials: DS
authors.lastname: Burke
authors.forename: Jean K
authors.initials: JK
authors.lastname: Carr
mesh_terms: D002163:Cameroon / Q000453:epidemiology; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D015658:HIV Infections / Q000453:epidemiology / Q000235:genetics*; D015528:HIV Seroprevalence; D015497:HIV-1; D006801:Humans; D019713:Receptors, CCR5 / Q000235:genetics*; D012423:Rural Health / Q000706:statistics & numerical data
chemical_list: D019713:Receptors, CCR5