(Aryloxyacetylamino)benzoic acid analogues: A new class of hypoxia-inducible factor-1 inhibitors.
Structural modification of a compound discovered during screening using an HRE-dependent reporter assay has revealed a novel class of HIF-1 inhibitors, which potently inhibit the HIF-1alpha protein accumulation and its target gene expression under hypoxic conditions in human hepatocellular carcinoma Hep3B cells.
Lee
Kyeong
K
Molecular Cancer Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea, 305-806.
Lee
Jeong Hyung
JH
Boovanahalli
Shanthaveerappa K
SK
Jin
Yinglan
Y
Lee
Mijeoung
M
Jin
Xuejun
X
Kim
Jin Hwan
JH
Hong
Young-Soo
YS
Lee
Jung Joon
JJ
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D051784:Aryl Hydrocarbon Receptor Nuclear Translocator / Q000037:antagonists & inhibitors; D001565:Benzoates / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D015687:Cell Hypoxia; D045744:Cell Line, Tumor; D004921:Erythropoietin / Q000037:antagonists & inhibitors / Q000235:genetics; D015870:Gene Expression; D006801:Humans; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D012333:RNA, Messenger / Q000037:antagonists & inhibitors; D013329:Structure-Activity Relationship; D042461:Vascular Endothelial Growth Factor A / Q000037:antagonists & inhibitors / Q000235:genetics
C497396:ARNT protein, human; D000970:Antineoplastic Agents; D001565:Benzoates; C497442:HIF1A protein, human; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D012333:RNA, Messenger; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; D004921:Erythropoietin; D051784:Aryl Hydrocarbon Receptor Nuclear Translocator