title: Cyathane diterpenes from Sarcodon cyrneus and evaluation of their activities of neuritegenesis and nerve growth factor production.
abstract: Two new cyathane diterpenes, cyrneine C (4) and D (5), were isolated from the mushroom Sarcodon cyrneus, along with previously isolated cyrneine A, B and glaucopine C. The structures of the novel diterpenoids were determined by the analysis of spectroscopic data. Effects of the cyrneines and glaucopine C on the NGF gene expression in 1321N1 cells and on neurite outgrowth on PC12 cells were evaluated.
authors.affiliation: Dipartimento di Chimica e Tecnologia del Farmaco-Sez. Chimica Organica, Università degli Studi, 06123 Perugia, Italy. marcotu@unipg.it
authors.forename: Maria Carla
authors.initials: MC
authors.lastname: Marcotullio
authors.forename: Rita
authors.initials: R
authors.lastname: Pagiotti
authors.forename: Federica
authors.initials: F
authors.lastname: Maltese
authors.forename: Gildas Norbert
authors.initials: GN
authors.lastname: Oball-Mond Mwankie
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Hoshino
authors.forename: Yutaro
authors.initials: Y
authors.lastname: Obara
authors.forename: Norimichi
authors.initials: N
authors.lastname: Nakahata
mesh_terms: D000363:Agaricales / Q000737:chemistry*; D000818:Animals; D002478:Cells, Cultured; D002855:Chromatography, Thin Layer; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D008401:Gas Chromatography-Mass Spectrometry; D015870:Gene Expression / Q000187:drug effects; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008968:Molecular Conformation; D009414:Nerve Growth Factors / Q000096:biosynthesis / Q000138:chemical synthesis* / Q000494:pharmacology*; D016501:Neurites / Q000187:drug effects*; D016716:PC12 Cells; D051381:Rats; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013055:Spectrophotometry, Infrared; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D004224:Diterpenes; D007202:Indicators and Reagents; D009414:Nerve Growth Factors; C497675:cyathane