[Comparative study of two preservation solutions in the initial function after bilateral human lung transplantation].
OBJECTIVE
Compare the influence of two preservation liquids, Euro-Collins (EC) and Perfadex (P) in the pulmonary graft function in the initial phase of lung transplant in humans.


METHODS
Retrospective study.


METHODS
Lung transplant unit of the ICU of a university hospital.


METHODS
A total of 79 patients were subjected to a transplant of both lungs. The pulmonary grafts were preserved with EC in 23 cases and with P in 56 cases.


METHODS
Pulmonary function was assessed on admission in the intensive care unit (ICU) with the PaO2/FiO2 ratio. Mortality, graft dysfunction stay in ICU and time of mechanical ventilation were also assessed at 30 days.


RESULTS
The PaO2/FiO2 ratio was significantly greater in the P group than in the EC both on admission (p<0.006) and at 12 hours (p=0.032) in the ICU. Graft dysfunction incidence was less in group P than in EC (p<0.045). There were no differences in regards to mortality at 30 days, stay in ICU and time of mechanical ventilation between both groups.


CONCLUSIONS
Preservation of the pulmonary graft with P as preservation liquid compared with EC is associated with better graft function in the initial phases of transplant of both lungs and with a decrease in the incidence of graft dysfunction.
Miñambres
E
E
Servicio de Medicina Intensiva, Hospital Universitario Marqués de Valdecilla, Santander, España. eminambres@yahoo.es
González-Castro
A
A
Rabanal
J M
JM
Suberviola
B
B
Ortega
F J
FJ
Zurbano
F
F
Díaz-Regañón
G
G
Llorca
J
J
D000328:Adult; D005260:Female; D006801:Humans; D016040:Lung Transplantation / Q000379:methods / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D019188:Organ Preservation Solutions; D012189:Retrospective Studies
D019188:Organ Preservation Solutions