Risk factors of local relapse in breast cancer: the importance of age.
OBJECTIVE
The objective of the present analysis is to know what risk factors affect local relapse in breast cancer.


METHODS
A total of 1165 patients diagnosed with early breast cancer were included. Boost dose was modulated in the presence of risk factors. Patients with one risk factor received a boost of 10 Gy, while 20 Gy was administered in those with two risk factors.


RESULTS
Median follow-up was of 60 months. Mean age of patients was 56.7+/-10.8 years. Local risk factors were present in 82.8% of patients. The probability of remaining free of local recurrence at 5 and 10 years is 97.7% (CI 95%: 96.7-98.7) and 94.5% (CI 95%: 92.1-96.9). Only age showed an impact in local relapse on multivariate analysis. Patients 40 years or younger had a relative risk of local relapse of 5.27 and patients 41-50 of 3.7 with respect to patients older than 50 years.


CONCLUSIONS
Patients 40 years or younger have a higher risk of local failure than older patients. Other risk factors such as tumour size, intraductal carcinoma or margin status could be masked by an increase of radiation dose.
Algara López
M
M
Institut d'Oncologia Radioteràpica, L'Institut Municipal d'Assistència Sanitària (IMAS), Universitat Pompeu Fabra, Hospital de l'Esperança, C/Sant Josep de la Montanya 12, 08024 Barcelona, Spain. malgara@imas.imim.es
Sanz Latiesas
X
X
Foro Arnalot
P
P
Lacruz Bassols
M
M
Reig Castillejo
A
A
Quera Jordana
J
J
Membrive Conejo
I
I
Lozano Galán
J
J
Rodríguez de Dios
N
N
D000230:Adenocarcinoma / Q000453:epidemiology* / Q000532:radiotherapy*; D000367:Age Factors; D001943:Breast Neoplasms / Q000453:epidemiology* / Q000532:radiotherapy*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology*; D012307:Risk Factors