[Effects on serum glucose and lipids in chronic exposure to lanthanum chloride in rat].
OBJECTIVE
To explore the effects of serum glucose and lipids by on chronically lanthanum exposure in rat.


METHODS
The Wistar rats were treated with oral exposure dose 0.1, 2 and 40 mg/kg of lanthanum chloride (LaCl(3)) respectively, after 90 days the rats were sacrificed and the blood was collected for measuring the glycosylated hemoglobin A (HbA1c), the serum was used for measuring glucose, total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) levels.


RESULTS
There were no any differences among the control and 3 dose LaCl(3) exposed rats on the blood HbA1c and serum Glu, TG and LDL-C levels (P > 0.05). The serum TC in 0.1 and 2 mg/kg LaCl(3) dose group rats were (1.38 +/- 0.14) mmol/L and (1.37 +/- 0.26) mmol/L respectively. It was lower than that of the controls (1.57 +/- 0.14) mmol/L significantly (P < 0.05), the serum HDL-C in 0.1 mg/kg dose group rats was (0.79 +/- 0.12) mmol/L and obviously lower than that of control group rats (0.93 +/- 0.10) mmol/L (P < 0.05).


CONCLUSIONS
0.1 - 40 mg/kg LaCl(3) chronically exposed have not greater effect on serum glucose, TG and LDL-C levels in rats, but the lower dose LaCl(3) chronic exposure might cause serum TC and HLD-C level decreasing.
Wang
Tian-Cheng
TC
Department of Clinical Laboratory, 3rd Hospital of Peking University, Beijing 100083, China.
He
Xiao
X
Zhang
Zhi-Yong
ZY
Jia
Guang
G
Wang
Xiang
X
Shen
Hui-Qi
HQ
Zhao
Yu-Liang
YL
D000818:Animals; D001786:Blood Glucose; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D004781:Environmental Exposure; D006442:Glycated Hemoglobin; D007811:Lanthanum / Q000633:toxicity*; D008055:Lipids / Q000097:blood*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D014280:Triglycerides / Q000097:blood
D001786:Blood Glucose; D002784:Cholesterol; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D006442:Glycated Hemoglobin; D007811:Lanthanum; D008055:Lipids; D014280:Triglycerides; C028521:lanthanum chloride