title: Development of a library of 6-arylcoumarins as candidate fluorescent sensors.
abstract: [structure: see text]. A bromocoumarin scaffold (1) was reacted with various boronic acid derivatives (2a-l) to afford a library of 6-arylcoumarins (3a-l). This library was found to contain candidate fluorescent sensors for peptidase activity and for nitric oxide.
authors.affiliation: School of Biomedical Science, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2-3-10 Kanda-Surugadai, Tokyo, Japan. hiraomc@tmd.ac.jp
authors.forename: Tomoya
authors.initials: T
authors.lastname: Hirano
authors.forename: Kenichi
authors.initials: K
authors.lastname: Hiromoto
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kagechika
mesh_terms: D015374:Biosensing Techniques; D001897:Boronic Acids / Q000737:chemistry*; D003374:Coumarins / Q000138:chemical synthesis* / Q000737:chemistry; D005456:Fluorescent Dyes / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure
chemical_list: D001897:Boronic Acids; D003374:Coumarins; D005456:Fluorescent Dyes