Absorption, transport, and tissue delivery of vitamin E.
Vitamin E is one of the most abundant lipid-soluble antioxidant agents found in plasma and cells of higher mammals. The uptake, transport and tissue delivery of alpha-tocopherol, a key vitamin E form, involves molecular, biochemical, and cellular processes closely related to overall lipid and lipoprotein homeostasis. This review highlights recent findings that have led to a better understanding of vitamin E transport, including intestinal absorption, hepatic transport, and cellular uptake of alpha-tocopherol in vivo. This new information may be critical for manipulation of vitamin E homeostasis in a variety of oxidative stress-related disease conditions in humans.
Rigotti
Attilio
A
Departamento de Gastroenterología, Facultad de Medicina, Pontificia Universidad Católica, Hospital UC, Marcoleta 367, Santiago, Chile. arigotti@med.puc.cl
D000818:Animals; D001692:Biological Transport; D006801:Humans; D007408:Intestinal Absorption / Q000502:physiology*; D008074:Lipoproteins / Q000097:blood; D018110:Receptors, Lipoprotein / Q000378:metabolism; D014018:Tissue Distribution; D014810:Vitamin E / Q000378:metabolism*
D008074:Lipoproteins; D018110:Receptors, Lipoprotein; D014810:Vitamin E