title: Hemolytic anemia: a rare but potentially serious adverse effect of captopril.
abstract: Captopril was the first oral angiotensin-converting enzyme (ACE) inhibitor available and, as such, has been extensively studied and in clinical use for many years. Several studies have defined captopril's efficacy in the treatment of congestive heart failure (CHF) as well as determined its safety profile. The most common adverse hematologic reactions associated with captopril use include neutropenia and agranulocytosis. This paper describes an uncommon and a potentially serious hematologic side effect associated with captopril-hemolytic anemia.
authors.affiliation: Duke University Medical Center, Durham, NC, USA.
authors.forename: Mark A
authors.initials: MA
authors.lastname: Trimble
authors.forename: Michael H
authors.initials: MH
authors.lastname: Sketch
authors.forename: Rajendra H
authors.initials: RH
authors.lastname: Mehta
mesh_terms: D000369:Aged, 80 and over; D000743:Anemia, Hemolytic / Q000139:chemically induced* / Q000175:diagnosis* / Q000628:therapy; D000959:Antihypertensive Agents / Q000009:adverse effects; D002216:Captopril / Q000009:adverse effects*; D005260:Female; D006801:Humans; D035583:Rare Diseases / Q000139:chemically induced / Q000175:diagnosis / Q000628:therapy; D016896:Treatment Outcome
chemical_list: D000959:Antihypertensive Agents; D002216:Captopril