title: Parkinson's disease and age-related alterations in brain oscillations during a Simon task.
abstract: This study investigated event-related oscillations associated with a Simon task in 11 Parkinson's disease patients, 11 age-matched, and 11 young participants. During this task, participants respond faster when the relative spatial positions of stimulus and response match (no response conflict exists) than when they do not match (response conflict exists). An increased response conflict (increase in reaction times known as Simon effect) was found in elderly control and Parkinson's patients compared with young participants. Group and condition differences were found in the delta and theta frequency range, which may reflect that Parkinson's patients and matched controls use different cognitive strategies for stimulus-response processing than young controls and neurophysiological correlates of such strategy are deficient in patients compared with age-matched controls.
authors.affiliation: Institute of Psychology and Cognition Research, Department of Neuropsychology and Behavioral Neurobiology, Center for Advanced Imaging, University of Bremen, and Clinic for Neurology, General Hospital Bremen-East, Bremen, Germany.
authors.forename: Christina
authors.initials: C
authors.lastname: Schmiedt-Fehr
authors.forename: Günter
authors.initials: G
authors.lastname: Schwendemann
authors.forename: Manfred
authors.initials: M
authors.lastname: Herrmann
authors.forename: Canan
authors.initials: C
authors.lastname: Basar-Eroglu
mesh_terms: D000222:Adaptation, Physiological / Q000502:physiology; D000223:Adaptation, Psychological / Q000502:physiology; D000328:Adult; D000368:Aged; D000375:Aging / Q000502:physiology; D001683:Biological Clocks / Q000502:physiology; D001921:Brain / Q000503:physiopathology*; D003071:Cognition / Q000502:physiology; D003072:Cognition Disorders / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology*; D004569:Electroencephalography; D005071:Evoked Potentials; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D010300:Parkinson Disease / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology*; D011237:Predictive Value of Tests; D011340:Problem Solving / Q000502:physiology; D011930:Reaction Time / Q000502:physiology