Secondary metabolites from Andrographis paniculata.
Two new flavonoid glycosides, 5-hydroxy-7,8-dimethoxy (2R)-flavanone-5-O-beta-D-glucopyranoside (1) and 5-hydroxy-7,8,2',5'-tetramethoxy-flavone-5-O-beta-D-glucopyranoside (2), and a new diterpenoid, andrographic acid (3), along with andrographidine A (4) were isolated from Andrographis paniculata, and their structures were determined on the basis of physicochemical and spectroscopic analysis. Compound 3 was evaluated for cytotoxicity to KB cells along with andrographolide, isoandrographolide, neoandrographolide and 14-deoxy-11,12-didehydroandrographolide obtained from A. paniculata in the present study. Cytotoxicity was observed for andrographolide and isoandrographolide with ED50 values of 6.5 and 5.1 microg/ml, respectively.
Li
Wenkui
W
Department of Medicinal Chemistry and Pharmacognosy (m/c 781), University of Illinois at Chicago, IL 60612, USA.
Xu
Xudong
X
Zhang
Hongjie
H
Ma
Cuiying
C
Fong
Harry
H
van Breemen
Richard
R
Fitzloff
John
J
D035685:Andrographis / Q000737:chemistry* / Q000378:metabolism*; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy; D004224:Diterpenes / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology*; D006801:Humans; D007624:KB Cells; D015394:Molecular Structure
D000970:Antineoplastic Agents; D004224:Diterpenes