Dry and wet prolines for asymmetric organic solvent-free aldehyde-aldehyde and aldehyde-ketone aldol reactions.
Dry and wet prolines were found to catalyze the direct aldol reactions of aldehyde-aldehyde and aldehyde-ketone, respectively, to afford aldols with excellent diastereo- and enantioselectivities, and an organic solvent-free reaction was realized in some cases.
Hayashi
Yujiro
Y
Department of Industrial Chemistry, Faculty of Engineering, Tokyo University of Science, Kagurazaka, Shinjuku-ku, Tokyo, 162-8601, Japan. hayashi@ci.kagu.tus.ac.jp
Aratake
Seiji
S
Itoh
Takahiko
T
Okano
Tsubasa
T
Sumiya
Tatsunobu
T
Shoji
Mitsuru
M