title: Vitamin C improves basal metabolic rate and lipid profile in alloxan-induced diabetes mellitus in rats.
abstract: Diabetes mellitus (DM)is a multi-factorial disease which is characterized by hyperglycaemia, lipoprotein abnormalities and oxidative stress. This study evaluated effect of oral vitamin C administration on basal metabolic rate and lipid profile of alloxan-induced diabetic rats. Vitamin C was administered at 200 mg/kg body wt. by gavage for four weeks to diabetic rats after which the resting metabolic rate and plasma lipid profile was determined. The results showed that vitamin C administration significantly (p less than 0.01) reduced the resting metabolic rate in diabetic rats; and also lowered plasma triglyceride, total cholesterol and low-density lipoprotein cholesterol. These results suggest that the administration of vitamin C in this model of established diabetes mellitus might be beneficial for the restoration of basal metabolic rate and improvement of lipid profile. This may at least in part reduce the risk of cardiovascular events seen in diabetes mellitus.
authors.affiliation: Department of Physiology, College of Medical Sciences, University of Calabar, Calabar, Nigeria. d_owu@yahoo.com
authors.forename: D U
authors.initials: DU
authors.lastname: Owu
authors.forename: A B
authors.initials: AB
authors.lastname: Antai
authors.forename: K H
authors.initials: KH
authors.lastname: Udofia
authors.forename: A O
authors.initials: AO
authors.lastname: Obembe
authors.forename: K O
authors.initials: KO
authors.lastname: Obasi
authors.forename: M U
authors.initials: MU
authors.lastname: Eteng
mesh_terms: D000818:Animals; D001205:Ascorbic Acid / Q000627:therapeutic use*; D001481:Basal Metabolism / Q000187:drug effects*; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy* / Q000378:metabolism; D050356:Lipid Metabolism / Q000187:drug effects*; D008297:Male; D051381:Rats; D017208:Rats, Wistar
chemical_list: D001205:Ascorbic Acid