Prognostic significance of stomatin-like protein 2 overexpression in laryngeal squamous cell carcinoma: clinical, histologic, and immunohistochemistry analyses with tissue microarray.
Stomatin-like protein 2 (SLP-2) is a novel cancer-related gene whose product promotes cell growth, tumorigenicity, and adhesion in human esophageal squamous cell carcinoma. The purpose of this study was to investigate whether SLP-2 is overexpressed in human laryngeal squamous cell carcinoma (LSCC) and, if so, the significance of its overexpression in relation to clinical parameters. By analyzing 124 cases of LSCC with a tissue microarray, we concluded that SLP-2 is overexpressed in LSCC as compared with the adjacent normal laryngeal epithelium (P = .000) and furthermore that SLP-2 expression correlates with clinical stage. Overexpression can be regarded as a significant prognostic factor, with higher expression being found in lymph node metastasis.
Cao
Wen-feng
WF
Department of Pathology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.
Zhang
Li-yong
LY
Liu
Ming-bo
MB
Tang
Ping-zhang
PZ
Liu
Zhi-hua
ZH
Sun
Bao-cun
BC
D014408:Biomarkers, Tumor / Q000032:analysis; D001798:Blood Proteins / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D007820:Laryngeal Mucosa / Q000378:metabolism; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000473:pathology; D008565:Membrane Proteins / Q000378:metabolism*; D011379:Prognosis; D046888:Tissue Array Analysis
D014408:Biomarkers, Tumor; D001798:Blood Proteins; D008565:Membrane Proteins; C406287:STOML2 protein, human