title: Partial 3D gene sequences of Coxsackie viruses reveal interspecies exchanges.
abstract: The 3D region of 46 clinical Coxsackievirus strains, primarily belonging to the human enterovirus B species (HEV-B), were analyzed using nucleotide distance matrices and phylogeny software. The conclusions from previously analyzed genomic regions (VP1-2A-2B-2C) of the aforementioned strains revealed that enteroviruses' inheritance is being guided by gene adaptation among viruses of different serotypes. In this report the comparison of partial VP1 and 3D gene phylogenies presented an obvious incongruence. Moreover, the phylogeny of 3D sequences of the strains revealed an unexpected (and for the first time reported) homology among strains of different species. The observations of our study indicate that conversion events such as multiple mutations or recombination among strains and unknown donors may occur during the evolution of circulating strains, leading, probably, to viruses with altered genome and virulence.
authors.affiliation: Department of Cell Biology and Biophysics, Faculty of Biology, University of Athens, Panepistimioupolis, Athens, Greece.
authors.forename: Eugenia
authors.initials: E
authors.lastname: Bolanaki
authors.forename: Christine
authors.initials: C
authors.lastname: Kottaridi
authors.forename: Panayotis
authors.initials: P
authors.lastname: Markoulatos
authors.forename: Zaharoula
authors.initials: Z
authors.lastname: Kyriakopoulou
authors.forename: Lukas
authors.initials: L
authors.lastname: Margaritis
authors.forename: Theodoros
authors.initials: T
authors.lastname: Katsorchis
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D004770:Enterovirus / Q000145:classification / Q000235:genetics*; D019143:Evolution, Molecular; D022761:Gene Transfer, Horizontal; D006801:Humans; D008969:Molecular Sequence Data; D010802:Phylogeny; D011995:Recombination, Genetic; D012703:Serotyping; D013045:Species Specificity