Vertebrate aging research 2006.
This Hot Topics review, the first in a projected annual series, discusses those articles, published in the last year, which seem likely to have a major impact on our understanding of the aging process in mammals and the links between aging and late-life illnesses. The year's highlights include studies of oxidation damage in the very-long-lived naked mole-rat, and of caloric restriction in monkeys, humans, and growth hormone-unresponsive mice. Two studies of resveratrol, one showing its ability to extend lifespan in a short-lived fish, the other demonstrating beneficial effects in mice subjected to a diet high in fat, may well be harbingers of a parade of intervention studies in the coming decade.
Austad
Steven N
SN
Department of Cellular & Structural Biology, Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center, San Antonio, TX, USA. austad@uthscsa.edu
D000375:Aging; D000818:Animals; D031204:Caloric Restriction; D006801:Humans; D051379:Mice; D051381:Rats; D012106:Research