A study of investigation of cadmium genotoxicity in rat bone cells using DNA microarray.
To examine the transcriptional responses of rat bone cells continuously exposed to cadmium, we performed DNA microarray analysis. Cadmium increased levels of expression of 13 genes, including genes for Spp1, and reduced those of 10 genes.
Ohba
Ken-ichi
K
Department of Health Administration, School of Allied Health Sciences, Kitasato University, 1-15-1 Kitasato, Sagamihara, Kanagawa 228-8555, Japan. kohba@kitasato-u.ac.jp
Okawa
Youhei
Y
Matsumoto
Yuki
Y
Nakamura
Yasuhiro
Y
Ohta
Hisayoshi
H
D000818:Animals; D001842:Bone and Bones / Q000166:cytology* / Q000187:drug effects*; D002104:Cadmium / Q000633:toxicity*; D005260:Female; D020411:Oligonucleotide Array Sequence Analysis; D051381:Rats; D017208:Rats, Wistar; D014158:Transcription, Genetic / Q000187:drug effects*
D002104:Cadmium