title: Decoding dosage compensation.
abstract: How the mechanisms of dosage compensation distinguish the sex chromosomes from the autosomes has been something of a mystery. A recent study in Caenorhabditis elegans has identified clusters of two common DNA motifs as a cis-acting code for the recruitment of the DCC, the protein complex that mediates dosage compensation.
authors.affiliation: Department of Pathology, University of Washington, Seattle, WA 98195, USA.
authors.forename: Xinxian
authors.initials: X
authors.lastname: Deng
authors.forename: Christine M
authors.initials: CM
authors.lastname: Disteche
mesh_terms: D000818:Animals; D001665:Binding Sites / Q000235:genetics; D017173:Caenorhabditis elegans / Q000235:genetics*; D004247:DNA / Q000235:genetics / Q000378:metabolism*; D004303:Dosage Compensation, Genetic / Q000235:genetics / Q000502:physiology*; D046912:Multiprotein Complexes / Q000235:genetics / Q000378:metabolism*; D011485:Protein Binding; D013045:Species Specificity; D014960:X Chromosome / Q000235:genetics*
chemical_list: D046912:Multiprotein Complexes; D004247:DNA