title: [Analgesia for childbirth in a patient with factor V Leiden mutation].
abstract: Factor V Leiden mutation is the most common congenital thrombophilic disorder, affecting between 5% and 8% of the Caucasian population. Pregnancy creates a state of hypercoagulability and all factors that increase the risk of thrombosis should be considered, as they may be cumulative. In recent years, the diagnosis of new allelic variants of thrombophilic states have increased the incidence of pregnant women receiving anticoagulant therapy, with the anesthetic considerations that implies. We report the case of a 33-year-old woman with heterozygous Leiden factor V mutation who was admitted with spontaneous amniorrhexis in the 38th week of gestation. She was taking low molecular weight heparin therapy. An epidural catheter was inserted to provide analgesia for labor, with all safety precautions to prevent an epidural hematoma. Epidural anesthesia is the technique of choice for obstetric labor in patients with hypercoagulability because of its effects of favoring blood flow and inhibiting clot formation.
authors.affiliation: Servicio de Anestesiología, Reanimación y Terapia del Dolor, Hospital Universitario Miguel Servet, Zaragoza. merypuertolas@yahoo.es
authors.forename: M
authors.initials: M
authors.lastname: Puértolas Ortega
authors.forename: B
authors.initials: B
authors.lastname: Izquierdo Villarroya
authors.forename: P
authors.initials: P
authors.lastname: Oliva Perales
authors.forename: N
authors.initials: N
authors.lastname: Lafuente Ojeda
authors.forename: J
authors.initials: J
authors.lastname: Izquierdo Villarroya
authors.forename: R
authors.initials: R
authors.lastname: Ruiz Pérez
mesh_terms: D020016:Activated Protein C Resistance / Q000188:drug therapy / Q000235:genetics*; D000328:Adult; D015360:Analgesia, Epidural; D016362:Analgesia, Obstetrical / Q000379:methods*; D000925:Anticoagulants / Q000627:therapeutic use; D004198:Disease Susceptibility; D017984:Enoxaparin / Q000627:therapeutic use; D005165:Factor V / Q000235:genetics*; D005260:Female; D046748:Hematoma, Epidural, Spinal / Q000517:prevention & control*; D006579:Heterozygote; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D008487:Medical History Taking; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000188:drug therapy / Q000235:genetics*; D011677:Punctures / Q000009:adverse effects; D012307:Risk Factors; D019851:Thrombophilia / Q000188:drug therapy / Q000235:genetics*; D013927:Thrombosis / Q000517:prevention & control
chemical_list: D000925:Anticoagulants; D017984:Enoxaparin; C095381:factor V Leiden; D005165:Factor V