title: ABC synthesis and antitumor activity of a series of Annonaceous acetogenin analogs with a threo, trans, threo, trans, threo-bis-tetrahydrofuran core unit.
abstract: Side-chain analogs of Annonaceous acetogenins with a threo, trans, threo, trans, threo-bis-tetrahydrofuran core unit have been prepared and tested for cytotoxicity against HCT-116 human colon cancer cells.
authors.affiliation: Department of Chemistry, University of Virginia, Charlottesville, VA 22904, USA. jam5x@virginia.edu
authors.forename: James A
authors.initials: JA
authors.lastname: Marshall
authors.forename: Jesse J
authors.initials: JJ
authors.lastname: Sabatini
authors.forename: Frederick
authors.initials: F
authors.lastname: Valeriote
mesh_terms: D054378:Acetogenins; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D045744:Cell Line, Tumor; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D015195:Drug Design; D004354:Drug Screening Assays, Antitumor; D005233:Fatty Alcohols / Q000138:chemical synthesis* / Q000737:chemistry; D005663:Furans / Q000737:chemistry*; D006801:Humans; D020128:Inhibitory Concentration 50; D007783:Lactones / Q000138:chemical synthesis* / Q000737:chemistry; D008956:Models, Chemical; D015394:Molecular Structure
chemical_list: D054378:Acetogenins; D000970:Antineoplastic Agents; D005233:Fatty Alcohols; D005663:Furans; D007783:Lactones; C018674:tetrahydrofuran