Population genetic data on four STR loci, PAI (CA)n, GpIIIa (CT)n, PLAT (TG)14 (CA)12, and NOS2A (CCTTT)n, in Mediterranean populations.
In the present study, we have analyzed four highly polymorphic regions (STRs) chosen from four candidate genes involved in: (1) Platelet aggregation: alpha subunit of the platelet GpIIb/GpIIIa integrin complex (GpIIIa (CT)n; 17q21.31), (2) Coagulation fibrinolysis: Plasminogen Activator Tissue (PLAT5 (TG)14(TA)12; 8p12-q11.2) and Plasminogen Activator Inhibitor-1 (PAI-1 (CA)n; 7q21.3-q22), (3) Oxidative metabolism: the inducible nitric oxide (NO) synthase (iNOS) gene (NOS2A (CCTTT)n; 17cen-q11.2). Allele frequencies for these four STR loci were investigated in several Mediterranean populations. The population data deviate from the Hardy-Weinberg equilibrium in all populations for GpIIIa (CT)n polymorphism.
Falchi
Alessandra
A
Department of Human Genetics, Faculty of Science, University of Corsica, BP52 20250 Corte Corsica, France. falchi@univ-corse.fr
Piras
Ignazio Stefano
IS
Giovannoni
Laurianne
L
Moral
Pedro
P
Vona
Giuseppe
G
Varesi
Laurent
L
D000352:Africa, Northern; D000483:Alleles; D016009:Chi-Square Distribution; D003627:Data Interpretation, Statistical; D005602:France; D005787:Gene Frequency; D005828:Genetics, Population; D006801:Humans; D039661:Integrin beta3 / Q000235:genetics*; D007558:Italy; D019083:Mediterranean Region; D018895:Microsatellite Repeats; D052247:Nitric Oxide Synthase Type II / Q000235:genetics*; D017395:Plasminogen Activator Inhibitor 1 / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012802:Sicily; D013030:Spain; D010959:Tissue Plasminogen Activator / Q000235:genetics*; D044465:White People / Q000235:genetics*
D039661:Integrin beta3; D017395:Plasminogen Activator Inhibitor 1; C496319:NOS2 protein, human; D052247:Nitric Oxide Synthase Type II; D010959:Tissue Plasminogen Activator