title: Aspirin challenge and desensitization for aspirin-exacerbated respiratory disease: a practice paper.
abstract: Aspirin desensitization is indicated for patients who have aspirin-exacerbated respiratory disease and whose asthma and/or rhinosinusitis is suboptimally controlled with inhaled corticosteroids and leukotriene-modifying drugs. In this practice paper, the general requirements for aspirin desensitization are presented, the locations where desensitizations can be safely performed are outlined, prechallenge patient preparation is discussed, an oral aspirin challenge protocol is presented, treatment of adverse reactions is reviewed, and maintenance of aspirin desensitization is discussed.
authors.affiliation: SCPMG-Kaiser Permanente San Diego, California, USA.
authors.forename: Eric
authors.initials: E
authors.lastname: Macy
authors.forename: Jonathan A
authors.initials: JA
authors.lastname: Bernstein
authors.forename: Mariana C
authors.initials: MC
authors.lastname: Castells
authors.forename: Sandra M
authors.initials: SM
authors.lastname: Gawchik
authors.forename: Tak H
authors.initials: TH
authors.lastname: Lee
authors.forename: Russell A
authors.initials: RA
authors.lastname: Settipane
authors.forename: Ronald A
authors.initials: RA
authors.lastname: Simon
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Wald
authors.forename: Katharine M
authors.initials: KM
authors.lastname: Woessner
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects / Q000276:immunology / Q000627:therapeutic use*; D001241:Aspirin / Q000009:adverse effects / Q000276:immunology / Q000627:therapeutic use*; D001249:Asthma / Q000139:chemically induced / Q000188:drug therapy / Q000517:prevention & control; D003888:Desensitization, Immunologic; D004342:Drug Hypersensitivity / Q000188:drug therapy* / Q000517:prevention & control; D006801:Humans; D012220:Rhinitis / Q000139:chemically induced / Q000188:drug therapy / Q000517:prevention & control; D012852:Sinusitis / Q000139:chemically induced / Q000188:drug therapy / Q000517:prevention & control
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D001241:Aspirin