title: Synchronization of intracellular proliferation and apoptosis in multinucleated giant cell carcinoma of the cervix. A case report.
abstract: BACKGROUND
  Squamous cell cancer of the human cervix presents within a limited numher of well-defined categories inclusive of a large cell variant. Multinucleated giant cell lesions do not feature in any current classification of malignancy of this type.
  
  
  METHODS
  A case of true multinucleated giant cell carcinoma of squamous cell origin of the cervix is described. Two separate, discontinuous types of giant cells were recognized. Remarkable synchronicity of both cell division-related DNA amplification and apoptosis-related DNA disassembly was found and is illustrated in detail using immunocytochemical demonstration of Ki-67 antigen distribution.
  
  
  CONCLUSIONS
  This case of multinucleated giant cell carcinoma of squamous cell origin, in light of observed synchronization of both proliferative and apoptotic nuclear activity, raises fundamental questions with respect to cytoplasmic factors controlling such processes.
authors.affiliation: Leiden Cytology and Pathology Laboratory, Leiden, Reínier de Graaf Gasthuis Hospital Group, Delft, the Netherlands. m.e.boon@lcpl.nl
authors.forename: Mathilde E
authors.initials: ME
authors.lastname: Boon
authors.forename: Frederike C
authors.initials: FC
authors.lastname: Siemens
mesh_terms: D000369:Aged, 80 and over; D017209:Apoptosis; D018286:Carcinoma, Giant Cell / Q000473:pathology*; D002294:Carcinoma, Squamous Cell / Q000473:pathology; D049109:Cell Proliferation; D005260:Female; D006801:Humans; D002583:Uterine Cervical Neoplasms / Q000473:pathology*