Severe anaphylactic reaction to human insulin in a diabetic patient.
A 46-year-old nonatopic woman who had been suffering from type 2 diabetes for 17 years was hospitalized at the Endocrinology Department of Selcuk University due to very high glucose levels after recovery from acute hepatitis A infection. She had never used insulin before. After first subcutaneous dose of human regular insulin, severe local allergic reaction developed. Desensitization to insulin was tried. One day later, ketoacidosis developed. Human regular insulin was again subcutaneously injected to the patient. Severe anaphylactic reaction occurred, and in spite of all the medical attempts to save the patient, she died.
Kaya
Ahmet
A
Division of Endocrinology and Metabolism, Department of Internal Medicine, Meram Medical Faculty, Selcuk University, Konya, Turkey.
Gungor
Kagan
K
Karakose
Serdar
S
D000707:Anaphylaxis / Q000139:chemically induced*; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy*; D016883:Diabetic Ketoacidosis / Q000139:chemically induced*; D004342:Drug Hypersensitivity / Q000209:etiology; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007279:Injections, Subcutaneous; D007328:Insulin / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D008875:Middle Aged
D007328:Insulin