[Expression of HOXC13 in ameloblastoma].
OBJECTIVE
To study the expression of HOXC13 mRNA in ameloblastoma (AB), and to investigate its biological significance.


METHODS
HOXC13 mRNA was examined in 47 cases of AB (primary AB 29 cases, recurrent AB 14 cases, malignant AB 4 cases). 2 cases of fibrous dysplasia of bone, 10 cases of keratocystic odontogenic tumor (KCOT) and 7 cases of normal oral mucosa were selected as control.


RESULTS
The positive rates of HOXC13 mRNA in AB, KCOT, and normal oral mucosa were 97.9% (46/47), 7/10 and 3/7, respectively. There was a significant difference among AB, OKC and normal mucosa (chi(2) = 21.665, P = 0.001). For HOXC13, the keratinizing cells and granulizing cells in AB were negative, some fibroblasts were positive, 2 cases of fibrous dysplasia of bone were positive.


CONCLUSIONS
HOXC13 was highly expressed in AB. The expression of HOXC13 mRNA in AB had heterogeneity, which could improve the epithelial proliferation, and its loss may lead to the cornification and degeneration of epithelial cells.
Zhong
Ming
M
Department of Pathology, School of Stomatology, China Medical University, Shenyang 110002, China. zhongming_oral@yahoo.com.cn
Wang
Jie
J
Gong
Yan-bing
YB
Li
Jin-cheng
JC
Zhang
Bo
B
Hou
Lin
L
D000293:Adolescent; D000328:Adult; D000564:Ameloblastoma / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D005260:Female; D015870:Gene Expression; D005801:Genes, Homeobox; D018398:Homeodomain Proteins / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa / Q000378:metabolism; D009808:Odontogenic Tumors / Q000235:genetics / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism; D055815:Young Adult
C410305:HOXC13 protein, human; D018398:Homeodomain Proteins; D012333:RNA, Messenger