title: CRM1-mediated nuclear export: to the pore and beyond.
abstract: CRM1 (chromosome region maintenance 1; also referred to as exportin1 or Xpo1) is a member of the importin beta superfamily of nuclear transport receptors, recognizing proteins bearing a leucine-rich nuclear export sequence. CRM1 is the major receptor for the export of proteins out of the nucleus and is also required for transport of many RNAs. Besides its established role in nuclear export, CRM1 is also implicated in various steps during mitosis, widening its functional spectrum within the cell.
authors.affiliation: Universität Göttingen; Zentrum für Biochemie und Molekulare Zellbiologie; Humboldtallee 23; 37073 Göttingen, Germany.
authors.forename: Saskia
authors.initials: S
authors.lastname: Hutten
authors.forename: Ralph H
authors.initials: RH
authors.lastname: Kehlenbach
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D005231:Fatty Acids, Unsaturated / Q000494:pharmacology; D006801:Humans; D028884:Karyopherins / Q000502:physiology*; D022022:Nuclear Pore / Q000502:physiology*; D028861:Nuclear Pore Complex Proteins / Q000502:physiology; D021381:Protein Transport / Q000187:drug effects; D012333:RNA, Messenger / Q000378:metabolism; D012342:RNA, Small Nuclear / Q000378:metabolism; D012343:RNA, Transfer / Q000378:metabolism; D018160:Receptors, Cytoplasmic and Nuclear / Q000502:physiology*; D018271:Signal Recognition Particle / Q000502:physiology; D020931:ran GTP-Binding Protein / Q000502:physiology; D000097606:Exportin 1 Protein
chemical_list: D005231:Fatty Acids, Unsaturated; D028884:Karyopherins; D028861:Nuclear Pore Complex Proteins; D012333:RNA, Messenger; D012342:RNA, Small Nuclear; D012343:RNA, Transfer; D018160:Receptors, Cytoplasmic and Nuclear; D018271:Signal Recognition Particle; D020931:ran GTP-Binding Protein; D000097606:Exportin 1 Protein; C085914:NUP214 protein, human; C038753:leptomycin B