title: Impact of lower urinary tract symptoms on quality of life using Functional Assessment Cancer Therapy scale.
abstract: OBJECTIVE
  To assess the impact of lower urinary tract symptoms (LUTS) on general quality-of-life (QOL) measures in an outpatient setting.
  
  
  METHODS
  A total of 1546 male patients aged 51 years or older and scoring more than 11 in the International Prostate Symptom Score completed the general version of the Functional Assessment Cancer Therapy, the Benign Prostatic Hyperplasia Impact Index, and additional questions. Previous prostatic surgery and neurourologic conditions were exclusion criteria, but the use of urologic medication was not.
  
  
  RESULTS
  LUTS and QOL were significantly related to age, with older patients presenting with more symptoms and worse QOL. In addition, the results showed negative correlations between LUTS and QOL. The division of the severity groups according to the International Prostate Symptom Score showed that patients from the severe group reported significantly worse QOL compared with the moderate group. The 32% variance in the FACT-G was explained by the International Prostate Symptom Score items, controlling for age. Nocturia combined with incomplete bladder emptying were the strongest predictors of QOL.
  
  
  CONCLUSIONS
  LUTS have considerable impact on the general well-being of the patient. Combined with age, they can explain up to 30% of the variance in QOL. Nocturia and incomplete emptying are the most troublesome symptoms.
authors.affiliation: Urodynamics Unit, CM Teknon, Barcelona, Spain. 25887jbm@comb.es
authors.forename: Jose E
authors.initials: JE
authors.lastname: Batista-Miranda
authors.forename: Beatriz
authors.initials: B
authors.lastname: Molinuevo
authors.forename: Yolanda
authors.initials: Y
authors.lastname: Pardo
mesh_terms: D000223:Adaptation, Psychological; D000367:Age Factors; D000368:Aged; D015331:Cohort Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D053158:Nocturia / Q000175:diagnosis / Q000453:epidemiology; D010358:Patient Participation; D011336:Probability; D011379:Prognosis; D011470:Prostatic Hyperplasia / Q000175:diagnosis* / Q000453:epidemiology / Q000523:psychology*; D011788:Quality of Life; D018570:Risk Assessment; D012720:Severity of Illness Index; D018434:Sickness Impact Profile; D011795:Surveys and Questionnaires; D016055:Urinary Retention / Q000175:diagnosis / Q000453:epidemiology; D014555:Urination Disorders / Q000175:diagnosis* / Q000453:epidemiology; D014563:Urodynamics