title: The incidence of nausea and vomiting of pregnancy (NVP): a comparison between depressed women treated with antidepressants and non-depressed women.
abstract: BACKGROUND
  Nausea and vomiting of pregnancy (NVP) affects up to 80% of pregnant women. In many cases NVP causes changes i n family, social, o roccupational functioning. Several studies have linked NVP with depression; however, whether depression preceded or resulted from NVP, has not been established.
  
  
  OBJECTIVE
  To examine whether pregnant women, diagnosed with depression pre-conceptionally, treated with an antidepressant, reported a higher incidence of NVP when compared with pregnant women without depression.
  
  
  METHODS
  In this pilot study, two groups of pregnant women who called the Motherisk Program in Toronto, Canada, were compared. Group 1 was comprised of 179 pregnant women who reported taking an antidepressant for the treatment of depression prior to pregnancy and in the first trimester. Group 2 was comprised of 179 pregnant women with no history of depression. The incidence of NVP in both groupswas recorded and compared.
  
  
  RESULTS
  In the depressed group 109/179 (61%) women reported suffering from NVP vs.121/179 (68%) in the non-depressed group (P = 0.1). The logistic regression analysis did not identify any independent variable as significantly explaining NVP.
  
  
  CONCLUSIONS
  Depression and treatment with antidepressants prior to and in early pregnancy, does not appear to affect the incidence of NVP.
authors.affiliation: The Motherisk Program, The Hospital for Sick Children, Toronto, Ontario, Canada.
authors.forename: Pina
authors.initials: P
authors.lastname: Bozzo
authors.forename: Gideon
authors.initials: G
authors.lastname: Koren
authors.forename: Alejandro A
authors.initials: AA
authors.lastname: Nava-Ocampo
authors.forename: Adrienne
authors.initials: A
authors.lastname: Einarson
mesh_terms: D000328:Adult; D000928:Antidepressive Agents / Q000627:therapeutic use*; D003863:Depression / Q000150:complications / Q000188:drug therapy*; D005260:Female; D020073:Gravidity; D006801:Humans; D016015:Logistic Models; D048968:Morning Sickness; D010298:Parity; D011247:Pregnancy
chemical_list: D000928:Antidepressive Agents