Large scale synthesis of the Cdc42 inhibitor secramine A and its inhibition of cell spreading.
We describe a large scale synthesis of secramine A. Consistent with its ability to inhibit activation of the small GTPase Cdc42, we find that secramine A inhibits cell spreading, a process previously shown to be Cdc42-dependent.
Xu
Bo
B
Department of Chemistry, University of Louisville, Louisville, Kentucky, 40292, USA.
Pelish
Henry
H
Kirchhausen
Tomas
T
Hammond
Gerald B
GB
D000818:Animals; D001552:Benzazepines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects; D048430:Cell Shape / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004847:Epithelial Cells / Q000166:cytology / Q000187:drug effects*; D007668:Kidney / Q000166:cytology / Q000187:drug effects; D008253:Macaca mulatta; D015394:Molecular Structure; D010091:Oximes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D013997:Time Factors; D020764:cdc42 GTP-Binding Protein / Q000037:antagonists & inhibitors*
D001552:Benzazepines; D010091:Oximes; C508970:secramine A; D020764:cdc42 GTP-Binding Protein