title: Repair of osteochondral defects with a new porous synthetic polymer scaffold.
abstract: We developed a new porous scaffold made from a synthetic polymer, poly(DL-lactide-co-glycolide) (PLG), and evaluated its use in the repair of cartilage. Osteochondral defects made on the femoral trochlear of rabbits were treated by transplantation of the PLG scaffold, examined histologically and compared with an untreated control group. Fibrous tissue was initially organised in an arcade array with poor cellularity at the articular surface of the scaffold. The tissue regenerated to cartilage at the articular surface. In the subchondral area, new bone formed and the scaffold was absorbed. The histological scores were significantly higher in the defects treated by the scaffold than in the control group (p<0.05). Our findings suggest that in an animal model the new porous PLG scaffold is effective for repairing full-thickness osteochondral defects without cultured cells and growth factors.
authors.affiliation: Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan.
authors.forename: I
authors.initials: I
authors.lastname: Nagura
authors.forename: H
authors.initials: H
authors.lastname: Fujioka
authors.forename: T
authors.initials: T
authors.lastname: Kokubu
authors.forename: T
authors.initials: T
authors.lastname: Makino
authors.forename: Y
authors.initials: Y
authors.lastname: Sumi
authors.forename: M
authors.initials: M
authors.lastname: Kurosaka
mesh_terms: D020341:Absorbable Implants; D000818:Animals; D002358:Cartilage, Articular / Q000293:injuries* / Q000473:pathology* / Q000601:surgery; D019902:Chondrocytes / Q000473:pathology; D004195:Disease Models, Animal; D019344:Lactic Acid / Q000627:therapeutic use*; D008855:Microscopy, Electron, Scanning; D016348:Osseointegration; D011100:Polyglycolic Acid / Q000627:therapeutic use*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011108:Polymers / Q000627:therapeutic use*; D011184:Postoperative Period; D011817:Rabbits
chemical_list: D011108:Polymers; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid