Secophnane-type alkaloids from Daphniphyllum oldhami.
Four new alkaloids, daphnioldhanins D-G (1-4, resp.), together with five known alkaloids, daphmacropodine (5), secodaphniphylline (6), deoxycalyciphylline B (7), deoxyisocalyciphylline B (8), and daphmanidin A (9), were isolated from the roots of Daphniphyllum oldhami. Their structures were elucidated on the basis of spectroscopic data and chemical methods. Compound 1 at 2.0 microM showed potent antioxidant activity against H(2)O(2)-induced impairment in PC12 cells.
Mu
Shu-Zhen
SZ
The Key Laboratory of Chemistry for Natural Product of Guizhou Province and Chinese Academy of Sciences, Guiyang 550002, PR China.
Yang
Xian-Wen
XW
Di
Ying-Tong
YT
He
Hong-Ping
HP
Wang
Ye
Y
Wang
Yue-Hu
YH
Li
Ling
L
Hao
Xiao-Jiang
XJ
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D016716:PC12 Cells; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats
D000470:Alkaloids; D000975:Antioxidants; D004365:Drugs, Chinese Herbal