Chilblain-like leukemia cutis.
We present a 6-year-old girl with an 8-month history of fluctuating chilblain-like lesions on the toes. A full blood count showed slight thrombocytopenia and monocytosis. A skin biopsy specimen showed a dense perivascular and superficial dermal cellular infiltrate which was CD3(-), CD43(+), and lysosyme + on immunocytochemistry, suggesting a monocytic origin. Juvenile myelomonocytic leukemia was diagnosed after a bone marrow biopsy and spontaneous marrow colony growth in culture.
Affleck
Andrew G
AG
Department of Dermatology, Queen's Medical Centre, University Hospital Nottingham NHS Trust, Nottingham, UK. andyaffleck@doctors.org.uk
Ravenscroft
Jane C
JC
Leach
Iain H
IH
D001706:Biopsy; D002647:Chilblains; D002648:Child; D005260:Female; D006801:Humans; D007938:Leukemia / Q000175:diagnosis* / Q000473:pathology; D015477:Leukemia, Myelomonocytic, Chronic / Q000175:diagnosis / Q000473:pathology*; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000473:pathology; D014034:Toes