Possible genetic correlation of an occipital dermal sinus in a mother and son. Case report.
Occipital dermal sinuses (ODSs) are congenital lesions located in the midline and characterized by a cutaneous pit or dimple. The intracranial extension as well as the associated symptoms are variable. To date, a familial occurrence of these lesions has not been reported. In this paper the authors report on a 2-year-old boy with an ODS and intracranial hypertension. The boy's mother had a similar lesion but did not have any complaints. Following their experience with this case and a literature review, the authors suggest that there may be a genetic basis in certain instances of ODS.
Ansari
Saeed
S
Department of Neurosurgery and Children's Hospital Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
Dadmehr
Majid
M
Nejat
Farideh
F
D000328:Adult; D001932:Brain Neoplasms / Q000150:complications / Q000601:surgery; D002675:Child, Preschool; D003388:Cranial Fossa, Posterior; D003884:Dermoid Cyst / Q000150:complications / Q000601:surgery; D005260:Female; D006801:Humans; D006849:Hydrocephalus / Q000209:etiology / Q000503:physiopathology / Q000601:surgery; D008279:Magnetic Resonance Imaging; D008297:Male; D019635:Neurosurgical Procedures; D009777:Occipital Bone / Q000002:abnormalities* / Q000473:pathology; D012720:Severity of Illness Index; D016136:Spina Bifida Occulta / Q000150:complications / Q000175:diagnosis* / Q000235:genetics* / Q000601:surgery