title: Insulin Autoimmune Syndrome possibly caused by alpha lipoic acid.
abstract: Insulin Autoimmune Syndrome (IAS) is a rare disease characterized by hypoglycemia and autoantibodies to insulin without prior insulin administration. Here, we report a case of IAS associated with alpha lipoic acid (ALA). The patient is a 55-year-old man. He began to complain of hypoglycemic symptoms after taking ALA. He lost consciousness in the late postprandial period and blood glucose was found to be 27 mg/dl. A high insulin level and high titers of insulin antibodies were detected. His HLA genotype contains DRB1* 0406. As ALA comes to be used widely, the incidence of IAS due to ALA might increase.
authors.affiliation: Department of Geriatrics, Shinshu University, Matsumoto, Japan. takeuti@hsp.md.shinshu-u.ac.jp
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Takeuchi
authors.forename: Takahide
authors.initials: T
authors.lastname: Miyamoto
authors.forename: Tomoko
authors.initials: T
authors.lastname: Kakizawa
authors.forename: Satoshi
authors.initials: S
authors.lastname: Shigematsu
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Hashizume
mesh_terms: D001323:Autoantibodies / Q000097:blood; D001327:Autoimmune Diseases / Q000097:blood / Q000139:chemically induced* / Q000235:genetics / Q000276:immunology*; D001786:Blood Glucose / Q000032:analysis; D005838:Genotype; D006684:HLA-DR Antigens / Q000235:genetics; D059811:HLA-DRB1 Chains; D006801:Humans; D007003:Hypoglycemia / Q000209:etiology; D007328:Insulin / Q000097:blood / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D008063:Thioctic Acid / Q000009:adverse effects*
chemical_list: D001323:Autoantibodies; D001786:Blood Glucose; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; C518670:HLA-DRB1*04:06 antigen; D007328:Insulin; D008063:Thioctic Acid