Left ventricular function in male patients with secondary hypogonadism.
BACKGROUND
In addition to the effects on ventricular repolarization, testosterone could also affect left ventricular performance. The enhancement of left ventricular contractility in testosterone-deficient rats following testosterone replacement implies to the possible testosterone effect.


OBJECTIVE
The aim of the current study is to reveal the alterations of left ventricular functions, if any, in secondary hypogonadal male patients.


METHODS
Thirty-four males with secondary hypogonadism comprised the study group. The control group consisted of 30 healthy subjects. Echocardiographic measurements including left ventricular dimensions, ejection fraction, mitral inflow, and left ventricular outflow parameters were obtained from all subjects. Tissue Doppler parameters were also measured from left ventricular lateral wall and interventricular septum.


RESULTS
Left ventricular diameters, wall thicknesses, and performance parameters were similar in both groups. Mitral inflow parameters showed a statistically insignificant difference. Pulse-wave tissue Doppler interpretation of hypogonadal and healthy subjects were similar in terms of lateral and septal basal segment Sm, Em, and Am wave velocities.


CONCLUSIONS
Regarding the findings of previous studies that showed impaired myocardial contractility and lusitropy in testosterone deficient rats and our study results, further studies are needed for better understanding of testosterone's effects on human myocardium.
Baysan
Oben
O
Department of Cardiology, Gulhane Military Medical Academy, Ankara, Turkey. obenbaysan@gmail.com
Bolu
Erol
E
Uzun
Mehmet
M
Kilicaslan
Fethi
F
Erinc
Kursad
K
Pinar
Murat
M
Hasimi
Adnan
A
Yokusoglu
Mehmet
M
Genc
Celal
C
Yelamanchili
Pridhvi
P
Karaeren
Hayrettin
H
Isik
Ersoy
E
D000328:Adult; D016022:Case-Control Studies; D018619:Echocardiography, Doppler, Pulsed; D006801:Humans; D007006:Hypogonadism / Q000150:complications*; D008297:Male; D012044:Regression Analysis; D018709:Statistics, Nonparametric; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging* / Q000209:etiology*