Design and synthesis of beta-methoxyacrylate analogues via click chemistry and biological evaluations.
A library of potential antifungal triazole-modified beta-methoxyacrylate analogues was designed and synthesized via a Cu(I)-catalyzed 1,3-dipolar alkyne-azide coupling reaction or 'click chemistry'. Subsequent biological screening revealed that some compounds displayed low to moderate antifungal activity toward pathogenic fungi and low phytotoxicity.
Chen
Hao
H
Plant Biotechnology Institute, National Research Council of Canada, 110 Gymnasium Place, Saskatoon, Sask., Canada S7N 0W9.
Taylor
Janet L
JL
Abrams
Suzanne R
SR
D000179:Acrylates / Q000138:chemical synthesis* / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000737:chemistry*; D000935:Antifungal Agents / Q000737:chemistry*; D001386:Azides / Q000737:chemistry; D002621:Chemistry / Q000379:methods; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D003300:Copper / Q000737:chemistry; D015195:Drug Design; D008956:Models, Chemical; D008968:Molecular Conformation; D031224:Raphanus / Q000378:metabolism
D000179:Acrylates; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D001386:Azides; D003300:Copper