Ikaros and chromatin regulation in early hematopoiesis.
Hematopoiesis is the developmental process by which all blood and immune cells are generated. A decade-old scheme has supported an early and complete separation of the erythro-myeloid from the lymphoid lineages. Recent advances have re-drawn this map, separating lymphoid and myeloid from erythroid programs early in development. Subsequently, the fate restriction of both the lympho-myeloid and the erythro-megakaryocyte progenitors is dependent on Ikaros and its associated chromatin regulators. Genetic studies of this family of nuclear factors are now providing unique insight into the functional molecular signatures that bestow plasticity to the hematopoietic stem cell and its early progeny.
Ng
Samuel Yao-Ming
SY
Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.
Yoshida
Toshimi
T
Georgopoulos
Katia
K
D000818:Animals; D002843:Chromatin / Q000235:genetics*; D015672:Erythroid Precursor Cells / Q000378:metabolism*; D018507:Gene Expression Regulation, Developmental; D006410:Hematopoiesis / Q000235:genetics*; D051740:Ikaros Transcription Factor / Q000235:genetics / Q000502:physiology*; D051379:Mice; D039902:Multipotent Stem Cells / Q000378:metabolism*
D002843:Chromatin; D051740:Ikaros Transcription Factor