Epigenetics in development.
It has become increasingly evident in recent years that development is under epigenetic control. Epigenetics is the study of heritable changes in gene function that occur independently of alterations to primary DNA sequence. The best-studied epigenetic modifications are DNA methylation, and changes in chromatin structure by histone modifications, and histone exchange. An exciting, new chapter in the field is the finding that long-distance chromosomal interactions also modify gene expression. Epigenetic modifications are key regulators of important developmental events, including X-inactivation, genomic imprinting, patterning by Hox genes and neuronal development. This primer covers these aspects of epigenetics in brief, and features an interview with two epigenetic scientists.
Kiefer
Julie C
JC
Department of Neurobiology and Anatomy, University of Utah, Salt Lake City, Utah 84132, USA. jkiefer@neuro.utah.edu
D000818:Animals; D001921:Brain / Q000196:embryology; D002454:Cell Differentiation; D019070:Cell Lineage / Q000235:genetics / Q000502:physiology; D042002:Chromatin Assembly and Disassembly; D002868:Chromosomal Proteins, Non-Histone / Q000502:physiology; D002875:Chromosomes / Q000502:physiology; D019175:DNA Methylation; D029721:Drosophila Proteins / Q000502:physiology; D047108:Embryonic Development / Q000235:genetics*; D044127:Epigenesis, Genetic / Q000502:physiology*; D018507:Gene Expression Regulation, Developmental; D014644:Genetic Variation; D000076983:Histone Methyltransferases; D011495:Histone-Lysine N-Methyltransferase / Q000378:metabolism; D006657:Histones / Q000235:genetics / Q000378:metabolism; D006801:Humans; D008745:Methylation; D018034:Olfactory Receptor Neurons / Q000502:physiology; D063146:Polycomb-Group Proteins; D011496:Protein Methyltransferases; D012097:Repressor Proteins / Q000502:physiology
D002868:Chromosomal Proteins, Non-Histone; D029721:Drosophila Proteins; D006657:Histones; D063146:Polycomb-Group Proteins; D012097:Repressor Proteins; C512571:trx protein, Drosophila; D000076983:Histone Methyltransferases; D011496:Protein Methyltransferases; D011495:Histone-Lysine N-Methyltransferase