Low contribution of n-3 polyunsaturated fatty acids to plasma and erythrocyte membrane lipids in diabetic young adults.
Hypoinsulinemia characteristic to type 1 diabetes may theoretically inhibit the conversion of essential fatty acids to their longer-chain metabolites. Fatty acids were determined in plasma and erythrocyte membrane lipids in young diabetic adults (n=34) and in age-matched healthy controls (n=36). Values of linoleic acid (56.01 [5.02] versus 51.05 [7.32], % by wt, median [range from the first to the third quartile], P<0.00l) and arachidonic acid (AA) (11.17 [2.98] versus 9.69 [1.95] P<0.001) were significantly higher in diabetic subjects than in controls. However, alpha-linolenic acid values did not differ, and docosahexaenoic acid (0.43 [0.12] versus 0.57 [0.29], P<0.01) values were significantly lower in diabetic than in control subjects. Significant inverse correlations were found between AA and hemoglobin A(1c) values in the phospholipid (r=-0.40, P<0.05) and sterol ester (r=-0.40, P<0.05) fractions. The data obtained in the present study suggest that the availability of n-3 long-chain polyunsaturated fatty acid may be reduced in young diabetic adults.
Decsi
T
T
Department of Paediatrics, University of Pécs, József A u 7, H-7623 Pécs, Hungary. tamas.decsi@aok.pte.hu
Szabó
E
E
Burus
I
I
Marosvölgyi
T
T
Kozári
A
A
Erhardt
E
E
Soltész
Gy
G
D000293:Adolescent; D000328:Adult; D016718:Arachidonic Acid / Q000032:analysis; D016022:Case-Control Studies; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000378:metabolism*; D004281:Docosahexaenoic Acids / Q000032:analysis; D004910:Erythrocyte Membrane / Q000737:chemistry; D005231:Fatty Acids, Unsaturated / Q000032:analysis*; D005260:Female; D005997:Glycerylphosphorylcholine / Q000032:analysis; D006441:Hemoglobin A / Q000378:metabolism; D006801:Humans; D019787:Linoleic Acid / Q000032:analysis; D008297:Male; D008563:Membrane Lipids / Q000737:chemistry*; D010714:Phosphatidylethanolamines / Q000032:analysis; D010743:Phospholipids / Q000032:analysis; D013261:Sterols / Q000032:analysis / Q000097:blood; D017962:alpha-Linolenic Acid / Q000032:analysis
D005231:Fatty Acids, Unsaturated; D008563:Membrane Lipids; D010714:Phosphatidylethanolamines; D010743:Phospholipids; D013261:Sterols; D017962:alpha-Linolenic Acid; D004281:Docosahexaenoic Acids; D016718:Arachidonic Acid; D005997:Glycerylphosphorylcholine; D006441:Hemoglobin A; D019787:Linoleic Acid