title: [Testicular malignant tumours. Efficacy of germ cell and sex cord tumours treatment protocol in Poland].
abstract: Approximately 2% of of all malignant tumours in boys are localised in the testis. Among them 80% are germ cell tumours with the malignant elements of yolk sac tumour. AIM of the study was evaluation of the efficacy of malignant testicular tumour treatment programme in children.
  
  
  METHODS
  Since 1998 31 boys aged 1 month to 18 years (median 14 years) with malignant testicular tumours were enrolled in the multicentre trial. Patomorphologically clear yolk sac tumour (33%) and mixed germ cell tumour (42%) with the majority of yolk sac tumour component or carcinoma embryonale, occurred most often. Alfa-feto-protein was increased in 63% and choriogonadotropin in 26 patients. 61% patients had local clinical stage and the tumour was localized in the testis. In 39% patients tumour exceeded the testis margin. 4 patients were excluded from analysis as 3 are actually treated and 1 died on the second day of admittance to hospital. All patients received TGM 95 regimen (Tumeurs Germinales Malignes). Surgery (orchidectomy) was applied in 27 boys, 26 were primary (81% complete), 3 secondary (100% complete). 33% received no chemotherapy after surgery, in 41% VBP protocol (vinblastine, bleomycin, cisplatin) was given and in 26%o VIP protocol (ethoposide, ifosphamide, cisplatin). Two patients received also ABK (adriamycine, bleomycin, carboplatin).
  
  
  RESULTS
  Among 26 children with germ cell tumours, 25 (96%) are alive, 23 (88%) are in first remission after completion of treatment. One child died due to central nervous system metastases. 2 children had local recurrence treated with chemotherapy or surgery with good result. Median follow-up is 45 months.
  
  
  CONCLUSIONS
  TGM regimen is highly efficient in the treatment of malignant testicular tumours. Problems occur in cases of disseminated disease.
authors.affiliation: Klinika Pediatrii, Gastroenterologii i Onkologii Dzieciecej, Akademia Medyczna, ul. Nowe Ogrody 1-6, 80-803 Gdańsk, Poland. step@amg.gda.pl
authors.forename: Stefan
authors.initials: S
authors.lastname: Popadiuk
authors.forename: Maria
authors.initials: M
authors.lastname: Korzon
authors.forename: Alicja
authors.initials: A
authors.lastname: Chybicka
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Szmyd
authors.forename: Maria
authors.initials: M
authors.lastname: Dzierzega
authors.forename: Joanna
authors.initials: J
authors.lastname: Trelińska
authors.forename: Jerzy R
authors.initials: JR
authors.lastname: Kowalczyk
authors.forename: Hanna
authors.initials: H
authors.lastname: Wiśniewska-Slusarz
authors.forename: Wojciech
authors.initials: W
authors.lastname: Woźniak
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Bilska
authors.forename: Jacek
authors.initials: J
authors.lastname: Wachowiak
authors.forename: Benigna
authors.initials: B
authors.lastname: Konatkowska
authors.forename: Mariusz
authors.initials: M
authors.lastname: Wysocki
authors.forename: Maryna
authors.initials: M
authors.lastname: Krawczuk-Rybak
authors.forename: Piotr
authors.initials: P
authors.lastname: Czauderna
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Szumera
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Sznurkowska
authors.forename: Joanna
authors.initials: J
authors.lastname: Renke
mesh_terms: D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use*; D001761:Bleomycin / Q000008:administration & dosage; D016190:Carboplatin / Q000008:administration & dosage; D002648:Child; D002675:Child, Preschool; D002945:Cisplatin / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D004334:Drug Administration Schedule; D018240:Endodermal Sinus Tumor / Q000188:drug therapy; D005047:Etoposide / Q000008:administration & dosage; D006801:Humans; D007069:Ifosfamide / Q000008:administration & dosage; D008297:Male; D009373:Neoplasms, Germ Cell and Embryonal / Q000188:drug therapy* / Q000473:pathology; D011044:Poland; D012074:Remission Induction; D018312:Sex Cord-Gonadal Stromal Tumors / Q000188:drug therapy* / Q000473:pathology; D013736:Testicular Neoplasms / Q000188:drug therapy* / Q000473:pathology; D016896:Treatment Outcome; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D001761:Bleomycin; D014750:Vincristine; D005047:Etoposide; D004317:Doxorubicin; D016190:Carboplatin; D002945:Cisplatin; D007069:Ifosfamide