title: Elevated BNP with normal systolic function in asymptomatic individuals at-risk for heart failure: a marker of diastolic dysfunction and clinical risk.
abstract: BACKGROUND
  B-type natriuretic peptide (BNP) is widely accepted in the evaluation of left ventricular systolic dysfunction and heart failure. However, little is known of the implications of elevated BNP levels in individuals with preserved systolic function (PSF).
  
  
  OBJECTIVE
  To investigate the drivers and clinical implications of elevated BNP levels in asymptomatic individuals with established PSF.
  
  
  METHODS
  We enrolled 154 individuals who all underwent physical examination, BNP evaluation and Doppler-echocardiographic studies. They were divided into those above and below the median BNP level (50 pg/ml).
  
  
  RESULTS
  Independent predictors of higher BNP were older age, more severe left ventricular hypertrophy (LVH), reduced E/A ratio and ischaemic heart disease. Survival and multivariable analysis demonstrated more death and/or admission in those above the median BNP (HR: 4.79, p=0.007).
  
  
  CONCLUSIONS
  Elevated BNP is the strongest, independent predictor of serious adverse cardiovascular outcomes in this population and requires closer clinical follow-up.
authors.affiliation: Heart Failure Unit, St Vincent's University Hospital, Dublin, Ireland.
authors.forename: S
authors.initials: S
authors.lastname: Karuppiah
authors.forename: F
authors.initials: F
authors.lastname: Graham
authors.forename: M
authors.initials: M
authors.lastname: Ledwidge
authors.forename: C
authors.initials: C
authors.lastname: Conlon
authors.forename: J
authors.initials: J
authors.lastname: Cahill
authors.forename: C
authors.initials: C
authors.lastname: O'Loughlin
authors.forename: J
authors.initials: J
authors.lastname: McManus
authors.forename: K
authors.initials: K
authors.lastname: McDonald
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D003971:Diastole; D015150:Echocardiography, Doppler; D005260:Female; D006333:Heart Failure / Q000097:blood* / Q000000981:diagnostic imaging* / Q000503:physiopathology; D006801:Humans; D008297:Male; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D011237:Predictive Value of Tests; D012372:ROC Curve; D015203:Reproducibility of Results; D012307:Risk Factors; D012680:Sensitivity and Specificity; D013599:Systole; D016277:Ventricular Function, Left; D016278:Ventricular Function, Right
chemical_list: D015415:Biomarkers; D020097:Natriuretic Peptide, Brain