title: [Study on supercritical carbon dioxide fluid extraction process of lignans from Kadsura heteroclita (Roxb.) Craib].
abstract: OBJECTIVE
  To optimize supercritical carbon dioxide fluid extraction process parameters of lignans from Kadsura heteroclita (Roxb.) Craib.
  
  
  METHODS
  The supercritical carbon dioxide fluid extraction was adopted to extract lignans. The contents of total lignans and gamma-schisandrin were determined to test the influence of pressure, temperature, grinding particle size and flow rate of CO2.
  
  
  RESULTS
  The extraction pressure and grinding particle size had significant effects on the content of total lignans and gamma-schisandrin. However, The extraction temperature and flow rate of CO2 had no significant effect on them.
  
  
  CONCLUSIONS
  The optimum process parameters are as fouons: pressure is 10 MPa, temperature is 45 degrees C, flow rate of CO2 is 30 L/h and herbs are granulated.
authors.affiliation: College of Pharmacy, Jinan University, Guangzhou 510632, China. morninglight202@163.com
authors.forename: Xiao-guang
authors.initials: XG
authors.lastname: Li
authors.forename: Qin
authors.initials: Q
authors.lastname: Gao
authors.forename: Wen
authors.initials: W
authors.lastname: Weng
authors.forename: Huan-min
authors.initials: HM
authors.lastname: Luo
mesh_terms: D000704:Analysis of Variance; D002245:Carbon Dioxide; D002851:Chromatography, High Pressure Liquid; D025924:Chromatography, Supercritical Fluid / Q000379:methods; D034242:Cyclooctanes / Q000032:analysis / Q000302:isolation & purification; D032135:Kadsura / Q000737:chemistry*; D017705:Lignans / Q000032:analysis / Q000302:isolation & purification*; D010316:Particle Size; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D011312:Pressure; D013678:Technology, Pharmaceutical / Q000379:methods*; D013696:Temperature
chemical_list: D034242:Cyclooctanes; D017705:Lignans; D002245:Carbon Dioxide