title: Mercury intoxication in a 2-year-old girl: a diagnostic challenge for the physician.
abstract: A 2-year-old girl presented with hypertension, anorexia and vomiting, restlessness, insomnia and acrodynia. Her blood pressure upon arrival was 145/98 mmHg. Ultrasound of the abdomen, CT scan of chest, abdomen and pelvis, and echocardiogram, were normal. Urinary levels of catecholamines were elevated, urine level of mercury was found to be high (33.2 microg/g creatinine), although blood level was normal (>0.5 microg/dl, reference value 0-4 microg/dl). Following a 1-month course of oral treatment with dimercaptosuccinic acid (DMSA) the child's symptoms and signs resolved, and urinary mercury and catecholamines levels normalized. Mercury intoxication should be suspected in a patient with severe hypertension, personality changes and acrodynia. Normal blood levels of mercury do not exclude this diagnosis, and catecholamine levels may serve as a surrogate marker for confirmation of the diagnosis and to evaluate response to treatment.
authors.affiliation: Department of Pediatrics, Assaf Harofeh Medical Center, Zerifin, 70300, Israel.
authors.forename: Yael
authors.initials: Y
authors.lastname: Michaeli-Yossef
authors.forename: Matitiahu
authors.initials: M
authors.lastname: Berkovitch
authors.forename: Michael
authors.initials: M
authors.lastname: Goldman
mesh_terms: D000170:Acrodynia / Q000175:diagnosis* / Q000209:etiology; D000931:Antidotes / Q000627:therapeutic use; D015415:Biomarkers / Q000652:urine; D002395:Catecholamines / Q000652:urine; D002614:Chelating Agents / Q000627:therapeutic use; D002675:Child, Preschool; D005260:Female; D006801:Humans; D006973:Hypertension / Q000139:chemically induced / Q000175:diagnosis*; D008628:Mercury / Q000652:urine; D008630:Mercury Poisoning / Q000150:complications / Q000175:diagnosis* / Q000652:urine; D004113:Succimer / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D000931:Antidotes; D015415:Biomarkers; D002395:Catecholamines; D002614:Chelating Agents; D004113:Succimer; D008628:Mercury