Hand sensory-motor cortical network assessed by functional source separation.
The functional source separation procedure (FSS) was applied to identify the activities of the primary sensorimotor areas (SM1) devoted to hand control. FSS adds a functional constraint to the cost function of the basic independent component analysis, and obtains source activity all along different processing states. Magnetoencephalographic signals from the left SM1 were recorded in 14 healthy subjects during a simple sensorimotor paradigm--galvanic right median nerve stimuli intermingled with submaximal isometric thumb opposition. Two functional sources related to the sensory flow in the primary cortex were extracted requiring maximal responsiveness to the nerve stimulation at around 20 and 30 ms (S1a, S1b). Maximal cortico-muscular coherence was required for the extraction of the motor source (M1). Sources were multiplied by the Euclidean norm of their corresponding weight vectors, allowing amplitude comparisons among sources in a fixed position. In all subjects, S1a, S1b, M1 were successfully obtained, positioned consistently with the SM1 organization, and behaved as physiologically expected during the movement and processing of the sensory stimuli. The M1 source reacted to the nerve stimulation with higher intensity at latencies around 30 ms than around 20 ms. The FSS method was demonstrated to be able to obtain the dynamics of different primary cortical network activities, two devoted mainly to sensory inflow, and the other to the motor control of the contralateral hand. It was possible to observe each source both during pure sensory processing and during motor tasks. In all conditions, a direct comparison of source intensities can be achieved.
Porcaro
Camillo
C
AFaR, Centre of Medical Statistics and IT, Fatebenefratelli Hospital, Rome, Italy. camillo.porcaro@afar.it
Barbati
Giulia
G
Zappasodi
Filippo
F
Rossini
Paolo M
PM
Tecchio
Franca
F
D000328:Adult; D000344:Afferent Pathways / Q000033:anatomy & histology / Q000502:physiology; D000368:Aged; D001931:Brain Mapping; D004525:Efferent Pathways / Q000033:anatomy & histology / Q000502:physiology; D004558:Electric Stimulation; D005260:Female; D006225:Hand / Q000294:innervation / Q000502:physiology*; D006801:Humans; D015225:Magnetoencephalography / Q000379:methods*; D008297:Male; D008475:Median Nerve / Q000502:physiology; D008875:Middle Aged; D009044:Motor Cortex / Q000033:anatomy & histology / Q000502:physiology*; D009068:Movement / Q000502:physiology; D009119:Muscle Contraction / Q000502:physiology; D018482:Muscle, Skeletal / Q000294:innervation / Q000502:physiology; D009415:Nerve Net / Q000033:anatomy & histology / Q000502:physiology*; D009431:Neural Conduction / Q000502:physiology; D011930:Reaction Time / Q000502:physiology; D012815:Signal Processing, Computer-Assisted; D013003:Somatosensory Cortex / Q000033:anatomy & histology / Q000502:physiology*; D013997:Time Factors