title: A case of acute hepatitis E associated with multidrug hypersensitivity and cytomegalovirus reactivation.
abstract: A 65-year-old Japanese man was hospitalized because of acute hepatitis and severe cholestasis due to hepatitis E virus (HEV) infection combined with a drug reaction to a cold preparation. He died of disseminated intravascular coagulation and severe intestinal bleeding due to systemic cytomegalovirus reactivation following the development of severe eruptions with marked eosinophilia due to drug hypersensitivity to taurine and ursodeoxycholate preparations. The close interaction between viral infection or reactivation and drug hypersensitivity was considered as a pathophysiology in this case, which emphasizes the need for further study of the immunological mechanism of the interaction.
authors.affiliation: First Department of Internal Medicine, Iwate Medical University, Morioka, Japan.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Takikawa
authors.forename: Yuki
authors.initials: Y
authors.lastname: Yasumi
authors.forename: Akihiro
authors.initials: A
authors.lastname: Sato
authors.forename: Ryujin
authors.initials: R
authors.lastname: Endo
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Suzuki
authors.forename: Yasuki
authors.initials: Y
authors.lastname: Mori
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Akasaka
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Miura
authors.forename: Takashi
authors.initials: T
authors.lastname: Sawai
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Okamoto