title: Fellow-eye comparison of posterior capsule opacification rates after implantation of 1CU accommodating and AcrySof MA30 monofocal intraocular lenses.
abstract: OBJECTIVE
  To measure posterior capsule opacification (PCO) and neodymium:YAG (Nd:YAG) capsulotomy rates between the AcrySof MA30 intraocular lens (IOL) (Alcon) and the 1CU IOL (HumanOptics) in a fellow-eye comparison.
  
  
  METHODS
  Ophthalmology Department, St. Thomas' Hospital, London, United Kingdom.
  
  
  METHODS
  Thirty patients who had bilateral cataract surgery with a 1CU IOL prospectively randomly allocated to 1 eye and an AcrySof MA30 monofocal IOL to the other eye were examined. Best corrected distance visual acuity was recorded using the Early Treatment Diabetic Retinopathy Study logMAR chart. Digital retroillumination images of the posterior capsule were taken with the pupil dilated and analyzed with POCO software.
  
  
  RESULTS
  Eyes with the 1CU IOL had significantly higher PCO rates than eyes with the MA30 IOL at all time points. By 2 years after surgery, 50% of eyes with a 1CU IOL had required Nd:YAG capsulotomy compared with no eyes with an MA30 IOL. There was no significant difference in visual acuity at any time point when post Nd:YAG capsulotomy was taken in to account.
  
  
  CONCLUSIONS
  The 1CU IOL has 4 broad optic-haptic junctions where the square-edged barrier is breached; this appeared to allow passage of lens epithelial cells, leading to an increase in PCO. However, the increased PCO cannot be attributed to this alone as the 1CU is hydrophilic, a factor known to be associated with higher PCO rates.
authors.affiliation: Ophthalmology Department, St. Thomas' Hospital, London, United Kingdom.
authors.forename: Joanne
authors.initials: J
authors.lastname: Hancox
authors.forename: David
authors.initials: D
authors.lastname: Spalton
authors.forename: Catherine
authors.initials: C
authors.lastname: Heatley
authors.forename: Hari
authors.initials: H
authors.lastname: Jayaram
authors.forename: Jennifer
authors.initials: J
authors.lastname: Yip
authors.forename: James
authors.initials: J
authors.lastname: Boyce
authors.forename: John
authors.initials: J
authors.lastname: Marshall
mesh_terms: D000065:Accommodation, Ocular; D000180:Acrylic Resins; D000368:Aged; D002386:Cataract / Q000209:etiology*; D005260:Female; D006801:Humans; D053685:Laser Therapy / Q000706:statistics & numerical data; D007903:Lens Capsule, Crystalline / Q000473:pathology* / Q000601:surgery; D019654:Lens Implantation, Intraocular / Q000009:adverse effects*; D007910:Lenses, Intraocular; D008297:Male; D011183:Postoperative Complications; D011446:Prospective Studies; D011474:Prosthesis Design
chemical_list: D000180:Acrylic Resins