title: Mitochondrial uncoupling protein 2 gene transcript levels are elevated in maturating erythroid cells.
abstract: Mitochondrial uncoupling protein 2 (UCP2) is abundant in developing monocyte/macrophage cells and may affect hematopoiesis by reducing formation of reactive oxygen species. The aims of this study were to further characterize the involvement of UCP2 in hematopoiesis. In situ hybridization in mouse embryos identified UCP2-positive cells in liver and inside primitive blood vessels from 10.5 days of prenatal development. High UCP2 transcript levels were detected in reticulocytes and other maturating erythroid cells in peripheral blood of mice exposed to hypoxia, and in umbilical cord blood of human neonates and peripheral blood of adults. Our results suggest involvement of UCP2 in erythropoiesis.
authors.affiliation: Department of Adipose Tissue Biology, Institute of Physiology, Academy of Sciences of the Czech Republic, Videnska 1083, 142 20 Prague, Czech Republic.
authors.forename: Pavel
authors.initials: P
authors.lastname: Flachs
authors.forename: Jana
authors.initials: J
authors.lastname: Sponarova
authors.forename: Pavel
authors.initials: P
authors.lastname: Kopecky
authors.forename: Ondrej
authors.initials: O
authors.lastname: Horvath
authors.forename: Anna
authors.initials: A
authors.lastname: Sediva
authors.forename: Maryse
authors.initials: M
authors.lastname: Nibbelink
authors.forename: Louis
authors.initials: L
authors.lastname: Casteilla
authors.forename: Dasa
authors.initials: D
authors.lastname: Medrikova
authors.forename: Jan
authors.initials: J
authors.lastname: Neckar
authors.forename: Frantisek
authors.initials: F
authors.lastname: Kolar
authors.forename: Jan
authors.initials: J
authors.lastname: Kopecky
mesh_terms: D000818:Animals; D016922:Cellular Senescence / Q000235:genetics*; D004622:Embryo, Mammalian; D041905:Erythroid Cells / Q000737:chemistry / Q000166:cytology*; D004920:Erythropoiesis / Q000235:genetics; D005312:Fetal Blood; D006801:Humans; D008099:Liver / Q000166:cytology; D051379:Mice; D011506:Proteins / Q000032:analysis / Q000235:genetics* / Q000502:physiology; D012333:RNA, Messenger / Q000032:analysis*; D012156:Reticulocytes / Q000737:chemistry
chemical_list: D011506:Proteins; D012333:RNA, Messenger; C035737:major urinary proteins