Peripheral gangrene associated with Kawasaki disease and successful management using prostacycline analogue: a case report.
We report a case of child-onset Kawasaki disease that presented as a prolonged fever and manifested with coronary aneurysms and peripheral gangrene of the lower limbs. Therapy with intravenous immunoglobulins, corticosteroids, aspirin, anticoagulants, and ilomedine, a prostacyclin analogue, resulted in rapid improvement in the patient's condition without extremity loss. Those treating patients with Kawasaki disease must be aware of possible vascular ischemia in the disease process that is reversible by early intervention treatments, including the use of a prostacycline analogue, that improve quality of life.
Dogan
Omer Faruk
OF
Department of Cardiovascular Surgery, Hacettepe University Medical Faculty, Ankara, Turkey. ofdogan@hacettepe.edu.tr
Kara
Ates
A
Devrim
Ilker
I
Tezer
Hasan
H
Besbas
Nesrin
N
Ozen
Seza
S
Secmeer
Gulten
G
Yorgancioglu
Cem
C
Boke
Erkmen
E
D002648:Child; D011464:Epoprostenol / Q000008:administration & dosage* / Q000031:analogs & derivatives*; D005260:Female; D005734:Gangrene / Q000188:drug therapy / Q000209:etiology; D006801:Humans; D007511:Ischemia / Q000209:etiology / Q000517:prevention & control*; D007866:Leg / Q000098:blood supply* / Q000473:pathology*; D009080:Mucocutaneous Lymph Node Syndrome / Q000150:complications* / Q000188:drug therapy*; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage; D016896:Treatment Outcome
D010975:Platelet Aggregation Inhibitors; D011464:Epoprostenol