Hyperglycemia: cell death in a cave.
Mitochondria play a central role in mediating high glucose-induced apoptosis. A recent study has shown that increases in glucose levels induce significant alterations in caveolae components, suggesting that high glucose may affect apoptotic signaling initiated in caveolae.
Smart
Eric J
EJ
University of Kentucky Medical Center, Lexington, KY 40504, USA. ejsmart@uky.edu
Li
Xiang-An
XA
D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D021941:Caveolae / Q000378:metabolism*; D016923:Cell Death / Q000502:physiology; D005947:Glucose / Q000502:physiology*; D006801:Humans; D006943:Hyperglycemia / Q000378:metabolism*; D008928:Mitochondria / Q000502:physiology*
D005947:Glucose