Inhibition of pyruvate decarboxylase from Z. mobilis by novel analogues of thiamine pyrophosphate: investigating pyrophosphate mimics.
Replacement of the thiazolium ring of thiamine pyrophosphate with a triazole gives extremely potent inhibitors of pyruvate decarboxylase from Z. mobilis, with K(I) values down to 20 pM; this system was used to explore pyrophosphate mimics and several effective analogues were discovered.
Erixon
Karl M
KM
Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.
Dabalos
Chester L
CL
Leeper
Finian J
FJ
D040761:Biomimetic Materials / Q000138:chemical synthesis / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D007700:Kinetics; D011767:Pyruvate Decarboxylase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D013835:Thiamine Pyrophosphate / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D014230:Triazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D017355:Zymomonas / Q000201:enzymology*
D004791:Enzyme Inhibitors; D014230:Triazoles; D011767:Pyruvate Decarboxylase; D013835:Thiamine Pyrophosphate