title: Interplay of pathogens, cytokines and other stress signals in the regulation of dendritic cell function.
abstract: Dendritic cells (DCs) are the only antigen-presenting cell capable of activating naïve T lymphocytes, and hence they play a crucial role in the induction of adaptive immunity. Immature DCs sample and process antigens, and efficiently sense a large variety of signals from the surrounding environment. Upon activation, they become capable to activate naïve T cells and to direct the differentiation and polarization of effector T lymphocytes. It is becoming increasingly clear that different signals are able to determine distinct programs of DC differentiation and different forms of immunity and tolerance. In the past few years many advances have been made in addressing the action exerted by pathogen-associated molecular patterns (PAMPs), cytokines, chemokines, and other less characterized stress molecules on the activity of DCs. In this review we focus on the multiplicity of innate signals able to modulate the functional profile of DCs.
authors.affiliation: Institute of Haematological Research, National Academy of Medicine and National Reference Centre for AIDS, Department of Microbiology, Buenos Aires University School of Medicine, Buenos Aires, Argentina.
authors.forename: Juan
authors.initials: J
authors.lastname: Sabatté
authors.forename: Julian
authors.initials: J
authors.lastname: Maggini
authors.forename: Karen
authors.initials: K
authors.lastname: Nahmod
authors.forename: María M
authors.initials: MM
authors.lastname: Amaral
authors.forename: Diego
authors.initials: D
authors.lastname: Martínez
authors.forename: Gabriela
authors.initials: G
authors.lastname: Salamone
authors.forename: Ana
authors.initials: A
authors.lastname: Ceballos
authors.forename: Mirta
authors.initials: M
authors.lastname: Giordano
authors.forename: Mónica
authors.initials: M
authors.lastname: Vermeulen
authors.forename: Jorge
authors.initials: J
authors.lastname: Geffner
mesh_terms: D000818:Animals; D017951:Antigen Presentation / Q000276:immunology*; D002454:Cell Differentiation / Q000276:immunology*; D016207:Cytokines / Q000276:immunology*; D003713:Dendritic Cells / Q000276:immunology*; D006801:Humans; D007108:Immune Tolerance; D007113:Immunity, Innate; D008213:Lymphocyte Activation / Q000276:immunology; D015398:Signal Transduction / Q000276:immunology*; D013312:Stress, Physiological / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D016207:Cytokines