title: Pharmacokinetic behaviour of enrofloxacin in greater rheas following a single-dose intramuscular administration.
abstract: The pharmacokinetic behaviour of enrofloxacin in greater rheas was investigated after intramuscular (IM) administration of 15 mg/kg. Plasma concentrations of enrofloxacin and its active metabolite, ciprofloxacin, were determined by high performance liquid chromatography. Enrofloxacin peak plasma concentration (C(max)=3.30+/-0.90 microg/mL) was reached at 24.17+/-9.17 min. The terminal half-life (t(1/2lambda)) and area under the curve (AUC) were 2.85+/-0.54 h and 4.18+/-0.69 microg h/mL, respectively. The AUC and C(max) for ciprofloxacin were 0.25+/-0.06 microg/mL and 0.66+/-0.16 microg h/mL, respectively. Taking into account the values obtained for the efficacy indices, an IM dose of 15 mg/kg of enrofloxacin would appear to be adequate for treating infections caused by highly susceptible bacteria (MIC(90)<0.03 microg/mL) in greater rheas.
authors.affiliation: Departamento de Toxicología y Farmacología, Facultad de Veterinaria, Universidad Complutense de Madrid, Spain.
authors.forename: José Julio
authors.initials: JJ
authors.lastname: de Lucas
authors.forename: Joaquín Luis
authors.initials: JL
authors.lastname: Navarro
authors.forename: Sonia
authors.initials: S
authors.lastname: Rubio
authors.forename: Pablo Emilio
authors.initials: PE
authors.lastname: Vignolo
authors.forename: Vilma Carina
authors.initials: VC
authors.lastname: Asis
authors.forename: Fernando
authors.initials: F
authors.lastname: González
authors.forename: Casilda
authors.initials: C
authors.lastname: Rodríguez
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D019540:Area Under Curve; D000077422:Enrofloxacin; D024841:Fluoroquinolones / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D007273:Injections, Intramuscular / Q000662:veterinary; D020311:Rheiformes / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones; D000077422:Enrofloxacin