Angiotensin II receptor signalling.
Angiotensin II plays a key role in the regulation of body fluid homeostasis. To correct body fluid deficits that occur during hypovolaemia, an animal needs to ingest both water and electrolytes. Thus, it is not surprising that angiotensin II, which is synthesized in response to hypovolaemia, acts centrally to increase both water and NaCl intake. Here, we review findings relating to the properties of angiotensin II receptors that give rise to changes in behaviour. Data are described to suggest that divergent signal transduction pathways are responsible for separable behavioural responses to angiotensin II, and a hypothesis is proposed to explain how this divergence may map onto neural circuits in the brain.
Daniels
Derek
D
Department of Psychology, State University of New York at Buffalo, Buffalo, NY 14260, USA. danielsd@buffalo.edu
Yee
Daniel K
DK
Fluharty
Steven J
SJ
D000804:Angiotensin II / Q000502:physiology; D000818:Animals; D004327:Drinking Behavior / Q000502:physiology; D005247:Feeding Behavior / Q000502:physiology; D006706:Homeostasis / Q000502:physiology; D020896:Hypovolemia / Q000503:physiopathology; D051381:Rats; D011945:Receptors, Angiotensin / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*; D012965:Sodium Chloride / Q000378:metabolism; D014867:Water / Q000378:metabolism; D014882:Water-Electrolyte Balance / Q000502:physiology*
D011945:Receptors, Angiotensin; D014867:Water; D000804:Angiotensin II; D012965:Sodium Chloride