[Experimental study on treatment of immune ulcerative colitis in mice by Changlu Enema].
OBJECTIVE
To observe the therapeutic effect of Chinese compound, Changlu Enema (CE), on immune ulcerative colitis (UC) in mice.


METHODS
Mice were randomly divided into the normal group, the model group, the CE high dose (CE-H) and low dose (CE-L) group and the salicylazosulfapyridine (SASP) group. All mice, except those in the normal group, were made into UC model by colonic mucosa protein immunization. After 21 days of medication, the changes of UC activity index and body weight in mice were observed, and the condition of colonic inflammation and histomorphological changes in colonic tissue were observed also.


RESULTS
UC activity index was lower and body weight was higher in the two CE groups than those in the model group respectively, showing significant difference (P < 0.05 or P < 0.01); pathological examination showed the pathological changes and inflammatory response in colonic tissue were relieved significantly after treatment, and the improvement in the CE-H group was better than that in the SASP group.


CONCLUSIONS
TCM compound CE is markedly effective in treating UC rats.
Wu
Yao-nan
YN
TCM Hospital of xiamen City, Fujian College of TCM, Fujian.
Xiao
Yu-qin
YQ
Chen
Yi-bin
YB
D000285:Administration, Rectal; D000818:Animals; D003093:Colitis, Ulcerative / Q000188:drug therapy* / Q000276:immunology; D003106:Colon / Q000187:drug effects / Q000473:pathology; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D008517:Phytotherapy; D011897:Random Allocation; D016896:Treatment Outcome
D004365:Drugs, Chinese Herbal; C528130:changlu