Enhancing the tolerance of poly(isobutylcyanoacrylate) nanoparticles with a modular surface design.
Polymer nanoparticles are designed as nanovehicles to carry drugs in the body in a controlled manner increasing the concentration of the biologically active substance in the diseased organs and cells. The safety and biocompatibility of these nanosystems are those of the many properties that nanoparticles must meet to be used in vivo. Here we show that the cytotoxicity profile of poly(isobutylcyanoacrylate) (PIBCA) nanoparticles is affected by the way the nanosystems were produced and by the design of their surface. It was found that the tolerance of PIBCA nanoparticles by cells could be improved up to 100-fold by coating their surface with polysaccharides and haemoglobin.
Chauvierre
Cédric
C
INSERM U779, Hôpital de Bicêtre, Secteur Broca, 78 rue du Général Leclerc, 94275 Le Kremlin-Bicêtre, France.
Leclerc
Liliane
L
Labarre
Denis
D
Appel
Martine
M
Marden
Michael C
MC
Couvreur
Patrick
P
Vauthier
Christine
C
D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D003487:Cyanoacrylates / Q000737:chemistry* / Q000633:toxicity; D003911:Dextrans / Q000737:chemistry*; D004659:Enbucrilate; D007941:Leukemia P388 / Q000473:pathology; D051379:Mice; D053758:Nanoparticles / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry* / Q000633:toxicity; D013499:Surface Properties
D003487:Cyanoacrylates; D003911:Dextrans; D011108:Polymers; D004659:Enbucrilate