title: Daily rhythms of liver-function indicators in rabbits.
abstract: Serum concentrations of urea and cholesterol were used as indicators of liver function in rabbits in an investigation of the responsiveness of the daily rhythm of liver function to phase shifts in the environmental light-dark cycle. Locomotor activity was simultaneously monitored by actigraphy. Serum urea and cholesterol concentrations exhibited robust daily rhythmicity with opposite phases. Both indicators of liver function phase shifted in response to phase shifts of the light-dark cycle. The phase shifts in liver function appeared to be parallel to phase shifts in locomotor activity, but the data were not sufficiently strong to confirm that the liver relies on the secondary effect of photic phase shift on ingestive behavior in order to be phase-shifted by light as previously indicated by gene expression studies in laboratory rodents.
authors.affiliation: Dipartimento di Morfologia, Biochimica, Fisiologia e Produzioni Animali, Laboratorio di Cronofisiologia Veterinaria, Facoltà di Medicina Veterinaria, Università degli Studi di Messina, 98168 Messina, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Piccione
authors.forename: G
authors.initials: G
authors.lastname: Caola
authors.forename: R
authors.initials: R
authors.lastname: Refinetti
mesh_terms: D000818:Animals; D002784:Cholesterol / Q000097:blood; D002940:Circadian Rhythm / Q000502:physiology*; D004435:Eating; D008099:Liver / Q000502:physiology*; D008111:Liver Function Tests; D009043:Motor Activity / Q000502:physiology; D017440:Photoperiod; D011817:Rabbits / Q000502:physiology*; D013045:Species Specificity; D014508:Urea / Q000097:blood
chemical_list: D014508:Urea; D002784:Cholesterol