title: Carotid intima-media thickness is different in large- and small-vessel ischemic stroke: the SMART study.
abstract: OBJECTIVE
  The role of athersclerosis in the difference between the pathogenesis of large-vessel disease (LVD) and small-vessel disease (SVD) is a matter of debate. Common carotid artery intima-media thickness (CCA IMT) is a marker of atherosclerosis. Our aim was to compare CCA IMT between SVD and LVD patients.
  
  
  METHODS
  Two independent observers classified ischemic stroke or transient ischemic attack as caused by SVD or LVD, primarily based on imaging and in addition on clinical features. Mean CCA IMT was calculated based on 6 measurements for each patient.
  
  
  RESULTS
  Four hundred and seventeen patients were classified LVD and 115 SVD. Mean CCA IMT was higher in patients with LVD (1.08 mm) than in patients with SVD (0.92 mm). The crude mean difference was 0.16 mm (95% CI, 0.09 to 0.23). After adjustment for age, sex and hypertension, the mean difference was 0.11 mm (95% CI, 0.05 to 0.18).
  
  
  CONCLUSIONS
  CCA IMT is higher in LVD patients than in SVD patients supporting the hypothesis that LVD and SVD have a different pathogenesis.
authors.affiliation: Department of Neurology, Rudolf Magnus Institute of Neuroscience, Utrecht, The Netherlands.
authors.forename: D Martijn O
authors.initials: DM
authors.lastname: Pruissen
authors.forename: Susan A M
authors.initials: SA
authors.lastname: Gerritsen
authors.forename: Talitha J
authors.initials: TJ
authors.lastname: Prinsen
authors.forename: Joke M
authors.initials: JM
authors.lastname: Dijk
authors.forename: L Jaap
authors.initials: LJ
authors.lastname: Kappelle
authors.forename: Ale
authors.initials: A
authors.lastname: Algra
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002545:Brain Ischemia / Q000209:etiology / Q000473:pathology* / Q000503:physiopathology; D002340:Carotid Artery Diseases / Q000150:complications / Q000473:pathology* / Q000503:physiopathology; D017536:Carotid Artery, Common / Q000473:pathology* / Q000503:physiopathology; D002536:Cerebral Arteries / Q000473:pathology / Q000503:physiopathology; D015331:Cohort Studies; D015897:Comorbidity; D005260:Female; D006801:Humans; D006973:Hypertension / Q000453:epidemiology; D002546:Ischemic Attack, Transient / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D008297:Male; D008833:Microcirculation / Q000473:pathology / Q000503:physiopathology; D008875:Middle Aged; D011446:Prospective Studies; D012737:Sex Factors; D020521:Stroke / Q000209:etiology / Q000473:pathology* / Q000503:physiopathology; D017539:Tunica Intima / Q000473:pathology / Q000503:physiopathology; D017540:Tunica Media / Q000473:pathology / Q000503:physiopathology