title: Reverse interactomics: from peptides to proteins and to functions.
abstract: Identifying associated partners is critical to understanding the potential function and upstream and downstream pathways of the molecule being studied. The Src homology 2 (SH2) domain is a binding module for peptides containing a phosphotyrosine residue, which is a post-translational modification that is heavily involved in signal transduction. A paper in this issue shows how "reverse interactomics" can be exploited to identify binding partners of the SH2 domain of tensin.
authors.affiliation: Lawrence Ellison Center for Tissue Regeneration and Repair, Department of Orthopaedic Surgery, Cancer Center, University of California-Davis, Sacramento, California 95817, USA. shlo@ucdavis.edu
authors.forename: Su Hao
authors.initials: SH
authors.lastname: Lo
mesh_terms: D000818:Animals; D006801:Humans; D008840:Microfilament Proteins / Q000378:metabolism; D010455:Peptides / Q000378:metabolism*; D011485:Protein Binding; D011506:Proteins / Q000378:metabolism*; D000070876:Tensins; D018909:src Homology Domains
chemical_list: D008840:Microfilament Proteins; D010455:Peptides; D011506:Proteins; D000070876:Tensins