title: A preliminary study of screening for risk of autism in children with fragile X syndrome: testing two risk cut-offs for the Checklist for Autism in Toddlers.
abstract: OBJECTIVE
  Risk criteria for the Checklist for Autism in Toddlers (CHAT) and modified risk criteria (i.e. the Denver Criteria) were compared in a group of children with fragile X syndrome (FXS) and autism.
  
  
  METHODS
  Participants were 17 children aged 2-4 years with DNA confirmation of FXS. Four children had autism and 13 children did not.
  
  
  RESULTS
  Preliminary findings regarding the sensitivity and specificity of the CHAT for detecting risk for autism in children with FXS are as follows: using the original CHAT risk criteria, sensitivity and specificity were 50% and 100%, respectively; and using the Denver Criteria, sensitivity and specificity were 75% and 92%, respectively.
  
  
  CONCLUSIONS
  The CHAT and the Denver Criteria resulted in preliminary findings suggesting high levels of sensitivity to autism in children with FXS.
authors.affiliation: Oklahoma State University, Stillwater, Oklahoma, USA. scambler@okstate.edu
authors.forename: D J
authors.initials: DJ
authors.lastname: Scambler
authors.forename: S L
authors.initials: SL
authors.lastname: Hepburn
authors.forename: R J
authors.initials: RJ
authors.lastname: Hagerman
authors.forename: S J
authors.initials: SJ
authors.lastname: Rogers
mesh_terms: D001321:Autistic Disorder / Q000150:complications* / Q000175:diagnosis*; D002675:Child, Preschool; D005260:Female; D005600:Fragile X Syndrome / Q000150:complications*; D006801:Humans; D008297:Male; D011237:Predictive Value of Tests; D018570:Risk Assessment / Q000379:methods; D012680:Sensitivity and Specificity