title: Bone formation around immediately placed oral implants in diabetic rats.
abstract: Research has shown a decrease in femoral bone-to-implant contact in rats with uncontrolled diabetes. The present study aimed to test the hypothesis that this decrease may be the result of a decreased mineral apposition rate. In 20 normal and 20 diabetic rats, a titanium implant was inserted into the tooth extraction socket immediately after the right maxillary molars were extracted. There was a significantly reduced mineral apposition rate in the diabetic rats compared with the normal rats (P = .0001), but no difference between rats sacrificed at 20 and 40 days (P = .297). The results suggest that implant insertion immediately following tooth extraction in patients with poorly controlled diabetes is contraindicated.
authors.affiliation: Division of Oral and Maxillofacial Surgery, Kaohsiung Military General Hospital, Republic of China.
authors.forename: Yih-Chuen
authors.initials: YC
authors.lastname: Shyng
authors.forename: Hugh
authors.initials: H
authors.lastname: Devlin
authors.forename: Keng-Liang
authors.initials: KL
authors.lastname: Ou
mesh_terms: D000818:Animals; D003758:Dental Implantation, Endosseous / Q000379:methods; D015921:Dental Implants; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced / Q000503:physiopathology*; D020007:Implants, Experimental; D016348:Osseointegration / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013311:Streptozocin; D020390:Tooth Socket
chemical_list: D015921:Dental Implants; D013311:Streptozocin