title: Asymmetric synthesis of novel alpha-amino acids with beta-branched side chains.
abstract: An asymmetric synthesis of alpha-amino acids with novel beta-branched side chains has been implemented. The syntheses feature a p-toluenesulfinylimine induced chiral Strecker approach and were found to be applicable to the introduction of both aliphatic and aromatic beta-branched sidechains for preparation of previously unknown alpha-amino acids.
authors.affiliation: Wyeth Research, CN 8000, Princeton, NJ 08543, USA. zhangm8@wyeth.com
authors.forename: Minsheng
authors.initials: M
authors.lastname: Zhang
authors.forename: Alex
authors.initials: A
authors.lastname: Porte
authors.forename: George
authors.initials: G
authors.lastname: Diamantidis
authors.forename: Kimberly
authors.initials: K
authors.lastname: Sogi
authors.forename: Dennis
authors.initials: D
authors.lastname: Kubrak
authors.forename: Lynn
authors.initials: L
authors.lastname: Resnick
authors.forename: Scott C
authors.initials: SC
authors.lastname: Mayer
authors.forename: Zheng
authors.initials: Z
authors.lastname: Wang
authors.forename: Anthony F
authors.initials: AF
authors.lastname: Kreft
authors.forename: Boyd L
authors.initials: BL
authors.lastname: Harrison
mesh_terms: D000596:Amino Acids / Q000138:chemical synthesis* / Q000737:chemistry*; D002625:Chemistry, Organic / Q000379:methods; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D015195:Drug Design; D008956:Models, Chemical; D008968:Molecular Conformation
chemical_list: D000596:Amino Acids