[Study on correlation of blood-stasis syndrome and its accompanied syndromes with pathological changes showed in coronary angiography and restenosis after percutaneous coronary intervention].
OBJECTIVE
To investigate the correlation of blood-stasis syndrome (BSS) and its accompanied syndromes with pathological changes showed in coronary angiography and restenosis after percutaneous coronary intervention (PCI).


METHODS
A total of 335 coronary heart disease patients after successful PCI were randomized into the treated group treated with Xiongshao Capsule (XC) and the control group treated with placebo for 6 months. BSS score was evaluated before and 6 months after PCI, and coronary angiography was followed up 6 months after the operation to perform the correlation analysis on BSS and its accompanied syndromes with types and complexity of coronary lesion, and the Logistic multivariate stepwise regression analysis (LMSRA) on the influencing factors of restenosis.


RESULTS
There were 334 cases with complete angiographic data, of which 308 cases (91.9%) finished the study, and among them 147 cases received a follow-up with angiography. Correlation analysis showed that the BSS score was significantly correlated to the maximal stenosis degree and coronary lesion score demonstrated by coronary angiography before PCI (P < 0.01), and the correlation was accentuated along with the increasing of the patients' age and the course of disease. Among the accompanied syndromes, the yang-deficiency syndrome was significantly correlated to the complexity of coronary lesions and the degree of stenosis, while the turbid- phlegm syndrome was correlated with calcification of the lesions. The difference of BSS score before and after treatment in the treated group was significantly higher than that in the control group. LMSRA showed that the recurrence of angina and BSS score were the important influencing factors on the occurrence of coronary restenosis after PCI. The incidence of restenosis was not correlated to the accompanied syndromes, and also showed no significant difference among patients with different syndrome types.


CONCLUSIONS
There is a certain correlation between BSS and the complexity of coronary lesions. The lesion is more severe in patients accompanied with yang-deficiency syndrome. The severity of BSS was an important influencing factor on the occurrence of restenosis after PCI, but no significant correlation was found between the occurrence and the type of accompanied syndromes.
Xu
Hao
H
National Integrative Medicine Center for Cardiovascular Diseases, China-Japan Friendship Hospital, Beijing. xuhao2005@yahoo.com.cn
Lu
Xiao-yan
XY
Chen
Ke-ji
KJ
D000328:Adult; D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D017023:Coronary Angiography; D003327:Coronary Disease / Q000000981:diagnostic imaging / Q000628:therapy*; D023903:Coronary Restenosis / Q000000981:diagnostic imaging* / Q000517:prevention & control; D003937:Diagnosis, Differential; D004311:Double-Blind Method; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008516:Medicine, Chinese Traditional; D008875:Middle Aged; D008517:Phytotherapy
D004365:Drugs, Chinese Herbal