Bithiazole metabolites from the myxobacterium Myxococcus fulvus.
Two new bithiazole metabolites (3, 4) along with the previously reported compounds (1, 2) were isolated from the culture broth of the gliding bacterium Myxococcus fulvus collected from a Korean soil. The structures of these compounds were determined to be analogous to myxothiazole A on the basis of combined spectroscopic analyses. The new compounds exhibited significant cytotoxicity and moderate antifungal activity against the mouse fibloblast cell-line L929 and Candida albicans, respectively. These data were consistent with the previous finding that the bioactivity of myxothiazoles was highly dependent on the presence of terminal methoxy enol functionality.
Ahn
Jong-Woong
JW
Division of Marine Environment & Bioscience, College of Ocean Science and Technology, Korea Maritime University, Youngdo, Busan, Korea.
Jang
Kyoung Hwa
KH
Yang
Hyeong-Cheol
HC
Oh
Ki-Bong
KB
Lee
Hyi-Seung
HS
Shin
Jongheon
J
D000818:Animals; D000935:Antifungal Agents / Q000737:chemistry / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects; D002460:Cell Line; D005347:Fibroblasts / Q000187:drug effects; D051379:Mice; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D016940:Myxococcus / Q000378:metabolism*; D013844:Thiazoles / Q000737:chemistry* / Q000378:metabolism*
D000935:Antifungal Agents; D013844:Thiazoles