title: Visual loss in the setting of allergic fungal sinusitis: pathophysiology and outcome.
abstract: OBJECTIVE
  To hypothesise the probable pathophysiological mechanism responsible for visual loss in allergic fungal sinusitis, other than direct compression.
  
  
  METHODS
  Retrospective, non-randomised case series. Out of 274 cases of allergic fungal sinusitis, four cases with sudden visual loss were enrolled into the study. The fourth case had visual loss on the contralateral side to bony erosion of the lateral wall of the sphenoid sinus.
  
  
  METHODS
  All four cases were evaluated with fungal smear, immunoglobulin (Ig) E titres, visual evoked potentials, non-contrast computed tomography and magnetic resonance imaging of the paranasal sinuses, and fundus examination. They then underwent endoscopic sinus debridement followed by intravenous methylprednisolone.
  
  
  METHODS
  Improvement in vision.
  
  
  RESULTS
  All four cases experienced an improvement in vision: full recovery in three cases and partial improvement in one case.
  
  
  CONCLUSIONS
  In view of the operative, radiological and laboratory findings for case four, with the suggestion of a hyperimmune response to fungal antigens (in the form of raised IgE titre and positive fungal serology), we suggest that a local immunological reaction to fungal antigens might be responsible for the observed visual loss in cases of allergic fungal sinusitis, in addition to mechanical compression of the optic nerve.
authors.affiliation: Department of Otolaryngology, Head and Neck Surgery, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
authors.forename: A K
authors.initials: AK
authors.lastname: Gupta
authors.forename: S
authors.initials: S
authors.lastname: Bansal
authors.forename: A
authors.initials: A
authors.lastname: Gupta
authors.forename: N
authors.initials: N
authors.lastname: Mathur
mesh_terms: D000328:Adult; D001228:Aspergillosis / Q000150:complications* / Q000628:therapy; D001766:Blindness / Q000209:etiology*; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000150:complications* / Q000382:microbiology; D008297:Male; D012189:Retrospective Studies; D012852:Sinusitis / Q000150:complications* / Q000382:microbiology; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome