title: [A case of multidrug-resistant non-small cell lung cancer responding to TS-1].
abstract: A 72-year-old man was admitted to our hospital, complaining of exertional breathlessness. Chest radiograph revealed a right pleural effusion. Cytology for pleural effusion revealed adenocarcinoma; thus, he was diagnosed with advanced lung cancer (clinical stage T 4 N 0 M 0, Stage IIIB). Since tumor recurrence occurred despite CBDCA+gemcitabine, docetaxel, gefitinib and vinorelbine administrations, he received fifth-line oral chemotherapy using TS-1 at 120 mg/day (80 mg/m(2)/day) for 28 days, followed by withdrawal for 14 days. Chest computed tomography showed a partial response. Hematologic and non-hematologic toxicities were mild with the TS-1 administration. TS-1 could be an effective agent for treatment of multidrug-resistant non-small cell lung cancer.
authors.affiliation: Dept. of Medicine and Molecular Science, Gunma University Graduate School of Medicine.
authors.forename: Hisao
authors.initials: H
authors.lastname: Imai
authors.forename: Noriaki
authors.initials: N
authors.lastname: Sunaga
authors.forename: Kyoichi
authors.initials: K
authors.lastname: Kaira
authors.forename: Shinichi
authors.initials: S
authors.lastname: Ishihara
authors.forename: Haruka
authors.initials: H
authors.lastname: Aoki
authors.forename: Hironobu
authors.initials: H
authors.lastname: Iijima
authors.forename: Noriko
authors.initials: N
authors.lastname: Yanagitani
authors.forename: Yasuki
authors.initials: Y
authors.lastname: Iwasaki
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Tomizawa
authors.forename: Ryusei
authors.initials: R
authors.lastname: Saito
authors.forename: Masatomo
authors.initials: M
authors.lastname: Mori
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000473:pathology; D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D004338:Drug Combinations; D018432:Drug Resistance, Multiple; D019008:Drug Resistance, Neoplasm; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D009367:Neoplasm Staging; D010094:Oxonic Acid / Q000627:therapeutic use*; D012074:Remission Induction; D005641:Tegafur / Q000627:therapeutic use*
chemical_list: D000964:Antimetabolites, Antineoplastic; D004338:Drug Combinations; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid