Randomized controlled trial of fosmidomycin-clindamycin versus sulfadoxine-pyrimethamine in the treatment of Plasmodium falciparum malaria.
Fosmidomycin-clindamycin therapy given every 12 h for 3 days was compared with a standard single oral dose of sulfadoxine-pyrimethamine. The two treatments showed comparably good tolerabilities and had an identical high degree of efficacy of 94% in a randomized trial carried out with 105 Gabonese children aged 3 to 14 years with uncomplicated malaria. These antimalarials merit further clinical exploration.
Oyakhirome
Sunny
S
Institute for Tropical Medicine, Department for Parasitology, University of Tübingen, Wilhelmstrasse 27, Tübingen, Germany.
Issifou
Saadou
S
Pongratz
Peter
P
Barondi
Fortune
F
Ramharter
Michael
M
Kun
Jürgen F
JF
Missinou
Michel A
MA
Lell
Bertrand
B
Kremsner
Peter G
PG
D000293:Adolescent; D000962:Antimalarials / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D002981:Clindamycin / Q000008:administration & dosage*; D004338:Drug Combinations; D005260:Female; D005578:Fosfomycin / Q000008:administration & dosage / Q000031:analogs & derivatives*; D006801:Humans; D016778:Malaria, Falciparum / Q000188:drug therapy*; D008297:Male; D011739:Pyrimethamine / Q000627:therapeutic use*; D013413:Sulfadoxine / Q000627:therapeutic use*
D000962:Antimalarials; D004338:Drug Combinations; D005578:Fosfomycin; C001205:fanasil, pyrimethamine drug combination; D002981:Clindamycin; C024640:fosmidomycin; D013413:Sulfadoxine; D011739:Pyrimethamine