[Bcl-2 expression following the brain concussion in rats].
OBJECTIVE
To evaluate the expression of Bcl-2 protein after brain concussion.


METHODS
Expression levels of Bel-2 protein in cortex, pontine and cerebellum of rats were investigated using immunohistochemistry.


RESULTS
There was no expression of Bcl-2 protein in control group seen. The expression of Bcl-2 protein in brain concussion groups was detected at l hour, and the expression level reached its peak 4 days after the concussion and then declined gradually.


CONCLUSIONS
Our findings suggest that the detection of Bel-2 protein could be an indicator for diagnosis of brain concussion and for estimation of the post injury time interval.
Zhu
Xu-yang
XY
Department of Forensic Medicine, Wannan Medical College, Wuhu 241001, China.
Wang
Feng
F
Fang
Wei-hua
WH
Wu
Mao-wang
MW
D000818:Animals; D001921:Brain / Q000378:metabolism / Q000473:pathology; D001924:Brain Concussion / Q000378:metabolism*; D001933:Brain Stem / Q000378:metabolism* / Q000473:pathology; D002540:Cerebral Cortex / Q000378:metabolism* / Q000473:pathology; D003288:Contusions / Q000378:metabolism / Q000473:pathology; D004195:Disease Models, Animal; D005260:Female; D007150:Immunohistochemistry; D008297:Male; D009474:Neurons / Q000378:metabolism / Q000473:pathology; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors
D019253:Proto-Oncogene Proteins c-bcl-2