title: Prediction of antigenic epitopes of neurotoxin Bmbktx1 from Mesobuthus martensii.
abstract: Gene therapy or recombinant DNA vaccines targeting multiple antigenic components to direct empower the immune system. Antigenic epitopes on neurotoxin Mesobuthus martensii (Buthus martensii) are important determinant of protection against cardiovascular disorder. Small segments 4-YSSDCRVKCVAM-15, 18-SSGKCINSKC-27 of neuro-toxin protein called the antigenic epitopes is sufficient for eliciting the desired immune response. In analysis predicted antigenic epitopes neurotoxin protein is seen. Immunization cassettes should be capable of immunizing of broad immunity against both humoral and cellular epitope thus giving vaccines the maximum ability to deal with neurotoxin protein of M. martensii. We have predicted a successful immunization.
authors.affiliation: Department of Bioinformatics, MGMs, College of Computer Science and Information Technology, Nanded, 431605 MS, India. virusgene1@yahoo.co.in
authors.forename: Virendra S
authors.initials: VS
authors.lastname: Gomase
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000941:Antigens / Q000737:chemistry* / Q000235:genetics; D000939:Epitopes / Q000737:chemistry* / Q000235:genetics / Q000276:immunology; D057927:Hydrophobic and Hydrophilic Interactions; D008958:Models, Molecular; D008969:Molecular Sequence Data; D009498:Neurotoxins / Q000737:chemistry* / Q000235:genetics / Q000276:immunology; D017433:Protein Structure, Secondary; D012604:Scorpion Venoms / Q000737:chemistry* / Q000235:genetics; D012605:Scorpions; D016415:Sequence Alignment / Q000379:methods; D017386:Sequence Homology, Amino Acid; D012995:Solubility
chemical_list: D000941:Antigens; D000939:Epitopes; D009498:Neurotoxins; D012604:Scorpion Venoms