title: [Preoperative radiotherapy in hypoxia in the complex treatment of the rectal carcinoma--long term results].
abstract: BACKGROUND
  The aim of this study was to evaluate long term results of patients with rectal carcinoma which were irradiated in hypoxic conditions.
  
  
  METHODS
  Of all patients which were irradiated in hypoxic conditions in Masaryk Memorial institute, 93 patients were followed up longer time than five year.
  
  
  RESULTS
  The most common surgical procedure was resection in 60%, overall five year survival was 73.1%, systemic relapse of disease occurred in 33.3% and local recurrence rate was 13.9%.
  
  
  CONCLUSIONS
  Preoperative irradiation in hypoxic conditions permits safe administration of doses higher than those tolerated by normooxic conditions, without increase of complication. Long term results are comparable with crucial trials.
authors.affiliation: I. Chirurgická klinika FNLP, Kosice.
authors.forename: V
authors.initials: V
authors.lastname: Sihotský
authors.forename: P
authors.initials: P
authors.lastname: Slampa
authors.forename: T
authors.initials: T
authors.lastname: Skricka
authors.forename: T
authors.initials: T
authors.lastname: Tacev
authors.forename: J
authors.initials: J
authors.lastname: Vomela
authors.forename: J
authors.initials: J
authors.lastname: Vsetícek
authors.forename: J
authors.initials: J
authors.lastname: Zaloudík
mesh_terms: D006801:Humans; D000860:Hypoxia; D020360:Neoadjuvant Therapy; D009364:Neoplasm Recurrence, Local; D011878:Radiotherapy / Q000379:methods*; D012004:Rectal Neoplasms / Q000401:mortality / Q000532:radiotherapy* / Q000601:surgery; D015996:Survival Rate