T-cell recognition of Paracoccidioides brasiliensis gp43-derived peptides in patients with paracoccidioidomycosis and healthy individuals.
Vaccines with synthetic peptides induce the immune response to epitopes that bind to several HLA alleles. By using a TEPITOPE algorithm, we selected and analyzed the T-cell responses of peripheral blood mononuclear cells from 29 paracoccidioidomycosis (PCM) patients to peptides of the immunodominant gp43 antigen of Paracoccidioides brasiliensis, the causative agent of PCM.
Iwai
Leo Kei
LK
Laboratory of Immunolgoy, Heart Institute (InCor), Millenium Institutes, São Paulo, Brazil.
Yoshida
Márcia
M
Sadahiro
Aya
A
da Silva
Washington Robert
WR
Marin
Maria Lucia
ML
Goldberg
Anna Carla
AC
Juliano
Maria Aparecida
MA
Juliano
Luiz
L
Shikanai-Yasuda
Maria Aparecida
MA
Kalil
Jorge
J
Cunha-Neto
Edecio
E
Travassos
Luiz R
LR
D000946:Antigens, Fungal / Q000276:immunology*; D002478:Cells, Cultured; D005656:Fungal Proteins / Q000276:immunology*; D006023:Glycoproteins / Q000276:immunology*; D006801:Humans; D010228:Paracoccidioides / Q000276:immunology*; D010229:Paracoccidioidomycosis / Q000276:immunology* / Q000382:microbiology; D010455:Peptides / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology* / Q000382:microbiology
C103180:43 kDa protein, Paracoccidioides; D000946:Antigens, Fungal; D005656:Fungal Proteins; D006023:Glycoproteins; D010455:Peptides