Epileptiformic activity induced by antidepressants in amygdala-kindled rats.
The present study was undertaken to investigate the spontaneous epileptiformic activity induced by antidepressants using amygdala-kindled rats. The intraperitoneal injection of imipramine and amitriptyline resulted in potent behavioral and electroencephalogram (EEG)-detected seizures in amygdala-kindled rats compared with those seen in sham rats (non-kindled rats). Almost the same findings were observed with clomipramine and maprotiline. On the other hand, paroxetine caused no or little behavioral or EEG seizures in either amygdala-kindled or sham rats, even at a dose of 50 mg/kg. In conclusion, our results indicate that epileptiformic activity induced by kindling increases the susceptibility to cyclic antidepressant-induced seizures.
Ago
Jun
J
Department of Medicinal Pharmacology, Okayama University Graduate, School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, 700-8530, Japan.
Ishikawa
Takashi
T
Matsumoto
Naotaka
N
Rahman
Md Ashequr
MA
Kamei
Chiaki
C
D000679:Amygdala / Q000187:drug effects / Q000502:physiology*; D000818:Animals; D000928:Antidepressive Agents / Q000008:administration & dosage / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects*; D004569:Electroencephalography / Q000187:drug effects; D004827:Epilepsy / Q000139:chemically induced*; D007274:Injections, Intraperitoneal; D007696:Kindling, Neurologic / Q000187:drug effects; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D000928:Antidepressive Agents