title: Synthesis of novel and uniquely shaped 3-azabicyclo[4.2.0]octan-4-one derivatives by sequential Ugi/[2+2] ene-enone photocycloadditions.
abstract: [structure: see text]. We report a new methodology for the construction of novel and uniquely shaped 3-azabicyclo[4.2.0]octan-4-one derivatives by combining the Ugi multicomponent reaction with [2+2] enone-olefin photochemical transformations. The overall sequence is capable of creating up to five stereocenters; however, in most cases, only two diastereomers are observed.
authors.affiliation: Scaffold Oriented Synthesis and Structural Chemistry, Abbott Laboratories, R4CP, AP10, Abbott Park, IL 60064-6099, USA. irini.zanze@abbott.com
authors.forename: Irini
authors.initials: I
authors.lastname: Akritopoulou-Zanze
authors.forename: Alan
authors.initials: A
authors.lastname: Whitehead
authors.forename: Jan E
authors.initials: JE
authors.lastname: Waters
authors.forename: Rodger F
authors.initials: RF
authors.lastname: Henry
authors.forename: Stevan W
authors.initials: SW
authors.lastname: Djuric