The regulation of ATP-dependent nucleosome remodelling factors.
The plasticity of chromatin is governed by multi-subunit protein complexes that enzymatically regulate chromosomal structure and activity. Such complexes include ATP-dependent chromatin remodelling factors that are involved in many fundamental processes such as transcription, DNA repair, replication and chromosome structure maintenance. Because ATP-dependent chromatin remodelling factors play important roles, it is not surprising to find that their functions are regulated in a plethora of ways, including post-translational modifications of their subunits and subunit composition changes. The activity of these enzymes is modulated by many factors, including linker histones, histone variants, histone chaperones, non-histone chromatin constituents such as HMG-proteins and secondary messengers, such as inositolpolyphosphates. Additionally, specific histone modifications and interaction with site-specific transcriptional regulators direct the targeting of these activities. Understanding the network of mechanisms that control ATP-dependent chromatin remodelling will constitute an important challenge towards our understanding of chromatin dynamics.
Hogan
Cassandra
C
Babraham Institute, Cambridge, UK.
Varga-Weisz
Patrick
P
D000255:Adenosine Triphosphate / Q000737:chemistry*; D000818:Animals; D002843:Chromatin / Q000378:metabolism*; D042002:Chromatin Assembly and Disassembly; D006657:Histones / Q000737:chemistry; D006801:Humans; D007294:Inositol / Q000737:chemistry; D009707:Nucleosomes / Q000378:metabolism*; D010766:Phosphorylation; D011122:Polyphosphates / Q000737:chemistry; D011499:Protein Processing, Post-Translational; D017434:Protein Structure, Tertiary
D002843:Chromatin; D006657:Histones; D009707:Nucleosomes; D011122:Polyphosphates; D007294:Inositol; D000255:Adenosine Triphosphate