Functional imaging of colorectal cancer angiogenesis.
Angiogenesis is a key factor in the growth and dissemination of colorectal cancer, with significant implications for its clinical management. Previous trials have provided proof-of-principle that inhibition of angiogenesis has the potential to enhance the effectiveness of treatment for this disease. Characterisation of the angiogenic status of the tumour on an individual patient basis could allow for a more targeted approach to treatment. In vivo imaging techniques that assess tumour microvessel function have the potential to improve the management of treatment for patients with colorectal cancer. This review focuses on MRI and CT assessment of colorectal cancer angiogenesis. We discuss the effects that these two techniques have had in the assessment of this disease, including tumour staging and therapeutic assessment. Their comparability with other imaging techniques, in particular ultrasound, and their limitations are also addressed.
Goh
Vicky
V
Paul Strickland Scanner Centre, Mount Vernon Hospital, Northwood, Middlesex, UK. vicky.goh@paulstrickland-scannercentre.org.uk
Padhani
Anwar R
AR
Rasheed
Shahnawaz
S
D015179:Colorectal Neoplasms / Q000098:blood supply* / Q000175:diagnosis* / Q000628:therapy; D006801:Humans; D008279:Magnetic Resonance Imaging; D009367:Neoplasm Staging; D009389:Neovascularization, Pathologic; D014057:Tomography, X-Ray Computed