title: Integrated Exposure Assessment Survey (INES) exposure to persistent and bioaccumulative chemicals in Bavaria, Germany.
abstract: The Integrated Exposure Assessment Survey (INES) was started in the year 2005. Altogether 50 healthy adults living in Bavaria, Germany, were included into the study. Monitoring was conducted in accordance with relevant routes of human exposure (inhalation, ingestion) and integrated different pathways (indoor air, food, house dust). This approach consisted of a combination of external measurements of contaminants with the determination of these substances or their metabolites in body fluids. The target substances were phthalates, perfluorinated compounds (PFC), polychlorinated biphenyls (PCBs), polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs), and polybrominated diphenylethers (PBDEs). This paper gives a brief description of the objectives and the concept of INES as well as methods of sampling and analyses of target compounds. Some preliminary results of biomonitoring data for PFC and phthalates as well as of the dietary intake of DEHP will be discussed.
authors.affiliation: Department of Environmental Health, Bavarian Health and Food Safety Authority, Veterinaerstrasse 2, 85764 Oberschleissheim, Germany. hermann.fromme@lgl.bayern.de
authors.forename: H
authors.initials: H
authors.lastname: Fromme
authors.forename: M
authors.initials: M
authors.lastname: Albrecht
authors.forename: J
authors.initials: J
authors.lastname: Angerer
authors.forename: H
authors.initials: H
authors.lastname: Drexler
authors.forename: L
authors.initials: L
authors.lastname: Gruber
authors.forename: M
authors.initials: M
authors.lastname: Schlummer
authors.forename: H
authors.initials: H
authors.lastname: Parlar
authors.forename: W
authors.initials: W
authors.lastname: Körner
authors.forename: A
authors.initials: A
authors.lastname: Wanner
authors.forename: D
authors.initials: D
authors.lastname: Heitmann
authors.forename: E
authors.initials: E
authors.lastname: Roscher
authors.forename: G
authors.initials: G
authors.lastname: Bolte
mesh_terms: D000293:Adolescent; D000328:Adult; D000393:Air Pollutants / Q000032:analysis / Q000378:metabolism*; D001572:Benzofurans / Q000097:blood / Q000652:urine; D015331:Cohort Studies; D000072338:Dibenzofurans, Polychlorinated; D015930:Diet Records; D004391:Dust / Q000032:analysis; D004781:Environmental Exposure / Q000032:analysis*; D004784:Environmental Monitoring; D005260:Female; D005506:Food Contamination / Q000032:analysis; D005858:Germany; D055768:Halogenated Diphenyl Ethers; D006306:Health Surveys; D006801:Humans; D008297:Male; D008875:Middle Aged; D010647:Phenyl Ethers / Q000097:blood / Q000652:urine; D010795:Phthalic Acids / Q000097:blood / Q000652:urine; D011078:Polychlorinated Biphenyls / Q000097:blood / Q000652:urine; D000072317:Polychlorinated Dibenzodioxins / Q000031:analogs & derivatives / Q000097:blood / Q000652:urine
chemical_list: D000393:Air Pollutants; D001572:Benzofurans; D000072338:Dibenzofurans, Polychlorinated; D004391:Dust; D055768:Halogenated Diphenyl Ethers; D010647:Phenyl Ethers; D010795:Phthalic Acids; D000072317:Polychlorinated Dibenzodioxins; C021244:polychlorinated diphenyl ethers; C032279:phthalic acid; D011078:Polychlorinated Biphenyls