Biclonal post-transplant B-cell lymphoma: report of a case with two distinct cell populations, XX,t(14;18) and XY,t(11;14).
Lymphoproliferative disorders are more likely to occur in transplant patients compared to the general population. Typically in these patients, lymphomas occur within 6-10 months following transplant and are Epstein-Barr virus (EBV) positive. We report a biclonal apparently EBV negative lymphoma occurring in a patient ten years after renal transplant, with karyotypes XX,t(14;18) and XY,t(11;14). Though the biclonal populations also had different sex chromosome compositions, complete evaluation showed that both clones most likely evolved from the patient's native lymphocytes.
Dennis
Katie L
KL
Department of Pathology and Laboratory Medicine, University of Kansas Medical Center/Kansas City VA Medical Center, 4801 Linwood Boulevard, Kansas City, Missouri 64128, USA.
Wallentine
Steven L
SL
Vanveldhuizen
Peter J
PJ
Persons
Diane L
DL
Mathur
Sharad C
SC
D000368:Aged; D002880:Chromosomes, Human, Pair 11; D002883:Chromosomes, Human, Pair 14; D002887:Chromosomes, Human, Pair 18; D041321:Chromosomes, Human, X; D041322:Chromosomes, Human, Y; D002999:Clone Cells / Q000378:metabolism / Q000473:pathology; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D016030:Kidney Transplantation; D016393:Lymphoma, B-Cell / Q000235:genetics* / Q000473:pathology; D008297:Male; D012729:Sex Chromosome Aberrations; D014178:Translocation, Genetic