Ultraviolet radiation exposure and risk of non-Hodgkin's lymphoma.
Sun exposure has been suggested to increase the risk of non-Hodgkin's lymphoma. The authors analyzed data from a population-based, case-control study of Connecticut women between 1996 and 2000 to study the hypothesis. Women who reported having had a suntan experienced an increased risk of non-Hodgkin's lymphoma with increasing duration (p(trend) = 0.0062) compared with women who reported never having had a suntan. An almost threefold increased risk of non-Hodgkin's lymphoma was observed among women who reported having had a suntan for less than 3 months per year and a suntan history of more than 60 years (odds ratio = 2.8, 95% confidence interval: 1.6, 4.9) compared with those who reported never having had a suntan. For women who reported having spent time in strong sunlight between 9 a.m. and 3 p.m. during the summer, a 70% increased risk of non-Hodgkin's lymphoma was observed for the highest tertile of duration compared with the lowest (odds ratio = 1.7, 95% confidence interval: 1.2, 2.4). The risk increased with increasing duration of time spent in strong sunlight in summer (p(trend) = 0.0051). The risk appears to vary by non-Hodgkin's lymphoma subtypes. Further investigations of the role of ultraviolet radiation on the risk of non-Hodgkin's lymphoma are warranted.
Zhang
Yawei
Y
Yale University School of Epidemiology and Public Health, New Haven, CT 06520-8034, USA. yawei.zhang@yale.edu
Holford
Theodore R
TR
Leaderer
Brian
B
Boyle
Peter
P
Zhu
Yong
Y
Wang
Rong
R
Zou
Kaiyong
K
Zhang
Bing
B
Wise
John Pierce
JP
Qin
Qin
Q
Kilfoy
Briseis
B
Han
Jiali
J
Zheng
Tongzhang
T
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D003237:Connecticut / Q000453:epidemiology; D004307:Dose-Response Relationship, Radiation; D004781:Environmental Exposure / Q000009:adverse effects*; D005260:Female; D006801:Humans; D016015:Logistic Models; D008228:Lymphoma, Non-Hodgkin / Q000453:epidemiology* / Q000209:etiology* / Q000473:pathology; D008875:Middle Aged; D012306:Risk; D014466:Ultraviolet Rays / Q000009:adverse effects*