title: Preliminary single-dose pharmacokinetics of marbofloxacin in ball pythons (Python regius).
abstract: Pharmacokinetics of marbofloxacin in two male and four female adult ball pythons (Python regius) was determined after i.v. and p.o. administration of a single dose. Using a crossover design, each snake was given a single 10 mg/kg dose of marbofloxacin i.v. and p.o. Blood samples were collected prior to and 0.5, 1, 1.5, 3, 6, 12, and 24 hr after marbofloxacin administration. Marbofloxacin was quantitated by use of liquid chromatography-mass spectrometry. Following p.o. administration, marbofloxacin had a peak plasma concentration (Cmax) of 9.40 microg/ml and a time to Cmax (Tmax) of 9.0 hr. Based on the plasma pharmacokinetics generated in this study and pending any further studies to evaluate potential toxicity and multi-dose pharmacokinetics, we suggest a dosage for marbofloxacin in ball pythons of 10 mg/kg p.o. at least every 48 hr, depending on the sensitivity of the pathogen and as a basis for further research.
authors.affiliation: Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan, Kansas 66506, USA.
authors.forename: Rob L
authors.initials: RL
authors.lastname: Coke
authors.forename: Ramiro
authors.initials: R
authors.lastname: Isaza
authors.forename: David E
authors.initials: DE
authors.lastname: Koch
authors.forename: Marie A
authors.initials: MA
authors.lastname: Pellerin
authors.forename: Robert P
authors.initials: RP
authors.lastname: Hunter
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000900:Anti-Bacterial Agents / Q000097:blood / Q000378:metabolism / Q000493:pharmacokinetics*; D019540:Area Under Curve; D001682:Biological Availability; D017821:Boidae / Q000097:blood* / Q000378:metabolism; D002853:Chromatography, Liquid / Q000662:veterinary; D018592:Cross-Over Studies; D005260:Female; D024841:Fluoroquinolones / Q000097:blood / Q000378:metabolism / Q000493:pharmacokinetics*; D007275:Injections, Intravenous / Q000662:veterinary; D008297:Male; D013058:Mass Spectrometry / Q000662:veterinary; D015363:Quinolones / Q000097:blood / Q000378:metabolism / Q000493:pharmacokinetics*
chemical_list: D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones; D015363:Quinolones; C080260:marbofloxacin