Low-dose pancreatic polypeptide inhibits food intake in man.
Pancreatic polypeptide (PP) is a gut hormone released from the pancreas in response to food ingestion and remains elevated for up to 6 h postprandially. Plasma levels are elevated in patients with pancreatic tumours. An intravenous infusion of PP has been reported to reduce food intake in man, suggesting that PP is a satiety hormone. We investigated whether a lower infusion rate of PP would induce significant alterations in energy intake. The study was randomised and double-blinded. Fourteen lean fasted volunteers (five men and nine women) received 90 min infusions of PP (5 pmol/kg per min) and saline on two separate days. The dose chosen was half that used in a previous human study which reported a decrease in appetite but at supra-physiological levels of PP. One hour after the end of the infusion, a buffet lunch was served and energy intake measured. PP infusion was associated with a significant 11 % reduction in energy intake compared with saline (2440 (se 200) v. 2730 (se 180) kJ; P<0 x 05). Preprandial hunger as assessed by a visual analogue score was decreased in the PP-treated group compared to saline. These effects were achieved with plasma levels of PP within the pathophysiological range of pancreatic tumours.
Jesudason
David R
DR
Department of Metabolic Medicine, Faculty of Medicene, Imperial College London, London, UK.
Monteiro
Mariana P
MP
McGowan
Barbara M C
BM
Neary
Nicola M
NM
Park
Adrian J
AJ
Philippou
Elena
E
Small
Caroline J
CJ
Frost
Gary S
GS
Ghatei
Mohammad A
MA
Bloom
Stephen R
SR
D000328:Adult; D001066:Appetite / Q000187:drug effects; D001067:Appetite Depressants / Q000494:pharmacology*; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D004435:Eating / Q000187:drug effects*; D002149:Energy Intake / Q000187:drug effects; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D010191:Pancreatic Polypeptide / Q000097:blood / Q000494:pharmacology*; D012527:Satiation / Q000187:drug effects*
D001067:Appetite Depressants; D010191:Pancreatic Polypeptide