[Mefenamic acid and other non-steroidal anti-inflammatory agents in dental practice. A review of the literature].
There are no studies verifying that mefenamic acid is more effective than other NSAID (= non-steroidal anti-inflammatory drugs). However, there are several notions in the literature that this drug is less well-tolerated than other NSAID because over a prolonged period of application more lesions of the upper gastro-intestinal tract are induced as well as occasionally renal insufficiency. Compared to other NSAID the systemic toxicity starts already with relatively low doses above the maximal daily dose. Considering current knowledge there is no reason to prefer mefenamic acid to other NSAID.
Künzel
André Rätzer
AR
Klinik für zahnärztliche Chirurgie, -Radiologie, Mund- und Kieferheilkunde der Universitätskliniken für Zahnmedizin, Basel.
Haschke
Manuel
M
Surber
Christian
C
Lambrecht
J Thomas
JT
D058186:Acute Kidney Injury / Q000139:chemically induced; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D006801:Humans; D008528:Mefenamic Acid / Q000009:adverse effects*; D053210:Pharmaceutical Preparations, Dental / Q000009:adverse effects; D013276:Stomach Ulcer / Q000139:chemically induced
D000894:Anti-Inflammatory Agents, Non-Steroidal; D053210:Pharmaceutical Preparations, Dental; D008528:Mefenamic Acid