title: [Two breakthroughs in CGD studies].
abstract: Studies in Chronic Granulomatous Disease showed two breakthroughs during this past decade. First, the discovery of 7 Nox/Duox family proteins, Noxo1 and Noxa1 (homologues of gp91(phox), p47(phox) and p67(phox)) may clarify novel physiological mechanisms for superoxide regulation in various organs, such as the regulation of blood pressure, mucosal defense system in respiratory/digestive tract and nephron. Secondly, the success in bone marrow transplantation and gene therapy for CGD should facilitate treatment for other genetic diseases as well.
authors.affiliation: Department of Reproductive and Developmental Medicine, Faculty of Medicne University of Miyazaki.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Nunoi
mesh_terms: D016026:Bone Marrow Transplantation; D015316:Genetic Therapy; D006105:Granulomatous Disease, Chronic / Q000201:enzymology / Q000235:genetics / Q000628:therapy; D006801:Humans; D008562:Membrane Glycoproteins / Q000235:genetics; D000074624:NADPH Oxidase 1; D000074662:NADPH Oxidase 2; D019255:NADPH Oxidases / Q000235:genetics
chemical_list: D008562:Membrane Glycoproteins; C056558:CYBB protein, human; D000074624:NADPH Oxidase 1; D000074662:NADPH Oxidase 2; D019255:NADPH Oxidases; C402799:NOX1 protein, human