Human serum amyloid A protein inhibits hepatitis C virus entry into cells.
Serum amyloid A (SAA) is an acute-phase protein induced by a variety of inflammatory stimuli, including bacterial and viral infections. SAA was recently found to function as an opsonin for gram-negative bacteria. We report here that SAA inhibited hepatitis C virus (HCV) infection in cultured cells. SAA reduced HCV infectivity in a dose-dependent manner when added during HCV infection but not after virus entry. SAA bound HCV virions and specifically blocked HCV entry but did not affect virus attachment. These findings suggest that SAA functions as part of the host innate immune defense mechanisms against HCV infection in humans.
Cai
Zhaohui
Z
Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky College of Medicine, 800 Rose Street, Lexington, KY 40536, USA.
Cai
Lei
L
Jiang
Jieyun
J
Chang
Kyung-Soo
KS
van der Westhuyzen
Deneys R
DR
Luo
Guangxiang
G
D045744:Cell Line, Tumor; D016174:Hepacivirus / Q000472:pathogenicity*; D006526:Hepatitis C / Q000517:prevention & control* / Q000821:virology*; D006801:Humans; D000685:Serum Amyloid A Protein / Q000502:physiology*; D053586:Virus Internalization
D000685:Serum Amyloid A Protein