Type III collagen mimetic peptides designed with anti- or pro-aggregant activities on human platelets.
We report the synthesis of collagen related peptides containing the peptide sequence Lys-Hyp-Gly-Glu-Hyp-Gly-Pro-Lys. The alpha-triple helix peptides behave as type III collagen analogues supporting platelet aggregation, while the homotrimer which does not exhibit a triple-helical conformation inhibits type III collagen-induced human platelet aggregation. The incorporation of the octapeptide sequence in type III collagen mimetic peptides may lead to the loss of the anti-thrombotic activity for a pro-thrombotic one.
Pires
Viviane
V
EA 3901, DMAG, Université de Picardie Jules Verne, UFR de Médecine et de Pharmacie, Amiens, France.
Pêcher
Julien
J
Da Nascimento
Sophie
S
Maurice
Pascal
P
Bonnefoy
Arnaud
A
Dassonville
Alexandra
A
Amant
Carole
C
Fauvel-Lafève
Françoise
F
Legrand
Chantal
C
Rochette
Jacques
J
Sonnet
Pascal
P
D000595:Amino Acid Sequence; D002942:Circular Dichroism; D024061:Collagen Type III / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D018716:Molecular Mimicry; D008969:Molecular Sequence Data; D019906:Nuclear Magnetic Resonance, Biomolecular; D010974:Platelet Aggregation / Q000187:drug effects*; D021241:Spectrometry, Mass, Electrospray Ionization
D024061:Collagen Type III