title: Atromentin and leucomelone, the first inhibitors specific to enoyl-ACP reductase (FabK) of Streptococcus pneumoniae.
abstract: Two potent inhibitors of FabK, the enoyl-acyl carrier protein (ACP) reductase of Streptococcus pneumoniae, were isolated from the solid state fermentation of an unidentified fungus F010248. Their structures were identified to be atromentin and leucomelone by various spectral analysis. Atromentin and leucomelone inhibited the FabK with IC50 values of 0.24 and 1.57 microM, respectively, while did not inhibit FabI, the enoyl-ACP reductase of either Escherichia coli or Staphylococcus aureus, even at 200 microM. Atromentin and leucomelone are the first inhibitors specific to the enoyl-ACP reductase (FabK) of Streptococcus pneumoniae.
authors.affiliation: Functional Metabolomics Research Center, Korea Research Institute of Bioscience and Biotechnology, Yusong, Daejeon 305-806, Republic of Korea.
authors.forename: Chang-Ji
authors.initials: CJ
authors.lastname: Zheng
authors.forename: Mi-Jin
authors.initials: MJ
authors.lastname: Sohn
authors.forename: Won-Gon
authors.initials: WG
authors.lastname: Kim
mesh_terms: D016227:Benzoquinones / Q000302:isolation & purification* / Q000494:pharmacology; D002396:Catechols / Q000302:isolation & purification* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D050753:Enoyl-(Acyl-Carrier-Protein) Reductase (NADH) / Q000037:antagonists & inhibitors*; D004791:Enzyme Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology; D005285:Fermentation; D005658:Fungi / Q000378:metabolism*; D010636:Phenols / Q000302:isolation & purification* / Q000494:pharmacology; D013296:Streptococcus pneumoniae / Q000201:enzymology*
chemical_list: D016227:Benzoquinones; D002396:Catechols; D004791:Enzyme Inhibitors; D010636:Phenols; C518214:leucomelone; C518213:atromentin; D050753:Enoyl-(Acyl-Carrier-Protein) Reductase (NADH)