title: Integrated microreaction system for optical resolution of racemic amino acids.
abstract: We developed a novel microreaction system for optical resolution of racemic amino acids. This device, which is based on a continuous microfluidic system, consists of an enzyme-immobilized microreactor and a microextractor. Use of the enzyme-microreactor, which was prepared by membrane formation on the microchannel surface, enabled a highly enantioselective reaction for a racemic amino acid derivative. The microextractor provided a laminar flow of two immiscible solutions, which enabled selective extraction of the product. Using this integrated device, we could perform efficient continuous production of optically pure unnatural amino acids.
authors.affiliation: Nanotechnology Research Institute, National Institute of Advanced Industrial Science and Technology, 807-1 Shuku, Tosu, Saga, 841-0052, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Honda
authors.forename: Masaya
authors.initials: M
authors.lastname: Miyazaki
authors.forename: Yoshiko
authors.initials: Y
authors.lastname: Yamaguchi
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Nakamura
authors.forename: Hideaki
authors.initials: H
authors.lastname: Maeda
mesh_terms: D000596:Amino Acids / Q000737:chemistry / Q000302:isolation & purification*; D013237:Stereoisomerism; D018511:Systems Integration
chemical_list: D000596:Amino Acids