title: Enteropathy-type T-cell lymphoma after intestinal diffuse large B-cell lymphoma.
abstract: A rare case of enteropathy-type T-cell lymphoma (ETL) developed in a 47-year-old Chinese male 6 years after the diagnosis of diffuse large B-cell lymphoma (DLBCL) in the small intestine. The patient initially presented with vague gastrointestinal complaints. Work-up demonstrated an ulcerated mass in the small intestine. Partial resection and histologic examination of the intestine showed a DLBCL, positive for CD20 and Bcl-2, involving the jejunum transmurally. Further staging work-up demonstrated mesenteric and retroperitoneal lymphadenopathy, splenomegaly, and ascites. The patient was treated aggressively with radiotherapy, chemotherapy, and autologous bone marrow transplant, and complete remission was obtained. Six years later, the patient presented with diarrhea and dehydration. Clinical work-up revealed thickening of the small intestinal wall, and biopsies demonstrated ETL based on morphology, immunohistochemistry, and polymerase chain reaction analysis. Celiac disease was diagnosed concurrently. The patient responded to chemotherapy, received allogeneic peripheral blood stem cell transplantation from an HLA-matched sibling donor, and remains in remission. To our best knowledge, this is the first reported case of metachronous ETL and DLBCL. Possible associations between the 2 types of lymphoma are discussed.
authors.affiliation: Department of Pathology, Lombardi Comprehensive Cancer Center, Georgetown University Hospital, Washington, DC 20007, USA.
authors.forename: Victor E
authors.initials: VE
authors.lastname: Nava
authors.forename: Philip
authors.initials: P
authors.lastname: Cohen
authors.forename: Michael
authors.initials: M
authors.lastname: Bishop
authors.forename: Daniel
authors.initials: D
authors.lastname: Fowler
authors.forename: Elaine S
authors.initials: ES
authors.lastname: Jaffe
authors.forename: Metin
authors.initials: M
authors.lastname: Ozdemirli
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis; D002446:Celiac Disease / Q000150:complications / Q000175:diagnosis; D017024:Chemotherapy, Adjuvant; D006801:Humans; D007150:Immunohistochemistry; D007414:Intestinal Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D016393:Lymphoma, B-Cell / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D016403:Lymphoma, Large B-Cell, Diffuse / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D016399:Lymphoma, T-Cell / Q000737:chemistry / Q000473:pathology* / Q000628:therapy; D008297:Male; D009367:Neoplasm Staging; D016609:Neoplasms, Second Primary / Q000473:pathology*; D036102:Peripheral Blood Stem Cell Transplantation; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor