Safety and tolerability of long lasting LDL-apheresis in familial hyperlipoproteinemia.
The aim of this work is to arbitrate the incidence of side effects and tolerability of long lasting LDL-apheresis in familial hyperlipoproteinemia. 1200 procedures were performed and the last 463 of them were evaluated. An immunoadsorption method of LDL-apheresis was used (continuous blood cell separator Cobe Spectra; secondary device: automated adsorption-desorption ADA, Medicap; absorption columns: Lipopak). As a whole, 6.26% adverse events were found and subsequently resolved by standard symptomatic therapy. Vaso-vagal reactions (symptoms of neurovegetative lability) were the most common adverse effects, presented as malaise, weakness, slight and short-term drop in blood pressure or other general signs. They were all well controlled by symptomatic therapy. We conclude that LDL-apheresis in the hands of experienced personnel is a safe procedure. An acceptable procedure duration limit, balancing the possibility to achieve a targeted cholesterol level while still maintaining an acceptable patient tolerance, was confirmed to be 4 hours.
Bláha
Milan
M
Department of Haematology, IInd Internal Clinic, Charles University, Hiradec Králové, Czech Republic. blaha@fnhk.cz
Cermanová
Melanie
M
Bláha
Vladimír
V
Blazek
Martin
M
Malý
Jaroslav
J
Siroký
Oldrich
O
Solichová
Dagmar
D
Filip
Stanislav
S
Rehácek
Vít
V
D000293:Adolescent; D000327:Adsorption; D000328:Adult; D008078:Cholesterol, LDL / Q000097:blood*; D005260:Female; D006801:Humans; D006951:Hyperlipoproteinemias / Q000097:blood / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D010956:Plasmapheresis
D008078:Cholesterol, LDL