High selectivity in new chiral separations of dansyl amino acids by cyclodextrin derivatives in electrokinetic chromatography.
Enantiomeric pairs of 11 dansyl derivatives of alpha-amino acids were used as analytes in electrokinetic chromatography to test the ability as chiral selectors of two pure derivatives of beta-cyclodextrin: the ethylendiamine derivative in primary position (CDen) and a member of a new class of receptors, the cysteamine-bridged hemispherodextrin THCMH. The selectivity obtained by the presence of the hemispherodextrin, appears particularly promising as shown by the large values of resolution obtained. The importance of a detailed analysis of these data is discussed in terms of suggestions for a rational approach to separation science.
Cucinotta
V
V
Department Chemical Sciences, University of Catania, Catania, Italy. ecucinotta@unict.it
Giuffrida
A
A
Grasso
G
G
Maccarrone
G
G
Messina
M
M
Vecchio
G
G
D000596:Amino Acids / Q000302:isolation & purification*; D020374:Chromatography, Micellar Electrokinetic Capillary / Q000379:methods*; D003505:Cyclodextrins; D003619:Dansyl Compounds; D019075:Electrophoresis, Capillary; D013237:Stereoisomerism
D000596:Amino Acids; D003505:Cyclodextrins; D003619:Dansyl Compounds