title: Evaluation of plasma skin regeneration technology in low-energy full-facial rejuvenation.
abstract: OBJECTIVE
  To evaluate the use of multiple, low-energy, full-face plasma skin regeneration treatments.
  
  
  METHODS
  Plasma skin regeneration delivers energy to the skin through plasma pulses induced by passing radiofrequency into nitrogen gas. Single-treatment, high-energy, 1-pass treatments have been demonstrated to achieve good results with an excellent safety profile. Eight volunteers underwent full-face treatments every 3 weeks, for a total of 3 treatments, using energy settings of 1.2 to 1.8 J. Before each subsequent treatment, the quality of regenerated epidermis, the degree of downtime, and erythema were recorded. Full-thickness skin biopsy specimens were obtained from 6 patients before treatment and 90 days following the last treatment. Patients were seen for follow-up 4 days after each treatment and 30 and 90 days after the third treatment.
  
  
  RESULTS
  Three months after treatment, investigators found a 37% reduction in facial rhytids and study participants noted a 68% improvement in overall facial appearance. Reepithelialization was complete in 4 days. Patients assessed erythema to persist an average of 6 days after treatment. Epidermal regeneration from the first treatment was longer than from the following treatments (9 vs 4 and 5 days, respectively). One patient developed localized hyperpigmentation after the first treatment, which resolved by follow-up at day 30. No scarring or hypopigmentation occurred. A histologic evaluation 3 months after treatment revealed a band of new collagen at the dermoepidermal junction with less dense elastin in the upper dermis. The mean depth of new collagen was 72.3 mum.
  
  
  CONCLUSIONS
  Plasma skin regeneration using the multiple low-energy treatment technique allows significant successful treatment of photodamaged facial skin with minimal downtime. Results are comparable to a single high-energy treatment, but with less healing time.
authors.affiliation: SkinCare Physicians, Chestnut Hill, MA, USA. mabogle@hotmail.com
authors.forename: Melissa A
authors.initials: MA
authors.lastname: Bogle
authors.forename: Kenneth A
authors.initials: KA
authors.lastname: Arndt
authors.forename: Jeffrey S
authors.initials: JS
authors.lastname: Dover
mesh_terms: D004867:Equipment Design; D005145:Face; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D028022:Low-Level Light Therapy / Q000295:instrumentation / Q000379:methods*; D012038:Regeneration / Q000528:radiation effects; D012060:Rejuvenation; D015595:Skin Aging / Q000473:pathology / Q000502:physiology / Q000528:radiation effects*; D013997:Time Factors