Omentin plasma levels and gene expression are decreased in obesity.
Central obesity and the accumulation of visceral fat are risk factors for the development of type 2 diabetes and cardiovascular disease. Omentin is a protein expressed and secreted from visceral but not subcutaneous adipose tissue that increases insulin sensitivity in human adipocytes. To determine the impact of obesity-dependent insulin resistance on the regulation of two omentin isoforms, gene expression and plasma levels were measured in lean, overweight, and obese subjects. Omentin 1 was shown to be the major circulating isoform in human plasma. Lean subjects had significantly higher plasma omentin 1 levels than obese and overweight subjects. In addition, higher plasma omentin 1 levels were detected in women compared with men. Plasma omentin 1 levels were inversely correlated with BMI, waist circumference, leptin levels, and insulin resistance as measured by homeostasis model assessment and positively correlated with adiponectin and HDL levels. Both omentin 1 and omentin 2 gene expression were decreased with obesity and were highly correlated with each other in visceral adipose tissue. In summary, decreased omentin levels are associated with increasing obesity and insulin resistance. Therefore, omentin levels may be predictive of the metabolic consequences or co-morbidities associated with obesity.
de Souza Batista
Celia M
CM
Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Yang
Rong-Ze
RZ
Lee
Mi-Jeong
MJ
Glynn
Nicole M
NM
Yu
Dao-Zhan
DZ
Pray
Jessica
J
Ndubuizu
Kelechi
K
Patil
Susheel
S
Schwartz
Alan
A
Kligman
Mark
M
Fried
Susan K
SK
Gong
Da-Wei
DW
Shuldiner
Alan R
AR
Pollin
Toni I
TI
McLenithan
John C
JC
D052242:Adiponectin / Q000097:blood; D000273:Adipose Tissue / Q000378:metabolism; D000328:Adult; D016207:Cytokines / Q000097:blood* / Q000235:genetics* / Q000302:isolation & purification; D005260:Female; D058851:GPI-Linked Proteins; D005786:Gene Expression Regulation; D006801:Humans; D037102:Lectins / Q000097:blood* / Q000235:genetics* / Q000302:isolation & purification; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood* / Q000235:genetics*; D018579:Patient Selection; D016133:Polymerase Chain Reaction; D012333:RNA, Messenger / Q000235:genetics
D052242:Adiponectin; D016207:Cytokines; D058851:GPI-Linked Proteins; C432397:ITLN1 protein, human; D037102:Lectins; D012333:RNA, Messenger