title: Quantitative evaluation of 2-deoxy-2[F-18]fluoro-D-glucose-positron emission tomography imaging on the woodchuck model of hepatocellular carcinoma with histological correlation.
abstract: OBJECTIVE
  The Eastern woodchuck (Marmota monax) is considered as a naturally occurring animal model of hepatocellular carcinoma (HCC). The performance of 2-deoxy-2-[F-18]fluoro-D-glucose (FDG) for imaging HCC on the woodchuck using Positron emission tomography (PET) was investigated in this study.
  
  
  METHODS
  Dynamic FDG-PET scans were performed on five woodchucks with HCC and one healthy woodchuck before removal and processing of the liver tissues for histology. The parameters of a two-tissue compartment model with dual input were estimated using weighted least squares (WLS).
  
  
  RESULTS
  Ten HCCs were confirmed histologically. Six HCCs had a tumor-to-liver standardized uptake value (SUV) ratio < or =1.15, a k (4) / k (3) ratio similar to that in hepatic tissues and were well-differentiated. Four HCCs had a tumor-to-liver SUV ratio >1.15, a lower k (4) / k (3) ratio than the hepatic tissues and were moderately differentiated.
  
  
  CONCLUSIONS
  Increased FDG uptake was observed in HCCs that were the least differentiated and correlated with a lower k (4) / k (3) ratio.
authors.affiliation: Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106, USA.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Salem
authors.forename: Gregory T
authors.initials: GT
authors.lastname: MacLennan
authors.forename: Yu
authors.initials: Y
authors.lastname: Kuang
authors.forename: Paul W
authors.initials: PW
authors.lastname: Anderson
authors.forename: Steve J
authors.initials: SJ
authors.lastname: Schomisch
authors.forename: Ilia A
authors.initials: IA
authors.lastname: Tochkov
authors.forename: Bud C
authors.initials: BC
authors.lastname: Tennant
authors.forename: Zhenghong
authors.initials: Z
authors.lastname: Lee
mesh_terms: D000818:Animals; D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D017919:Hepatitis B Virus, Woodchuck / Q000472:pathogenicity; D008114:Liver Neoplasms, Experimental / Q000000981:diagnostic imaging* / Q000473:pathology* / Q000821:virology; D008392:Marmota; D015233:Models, Statistical; D049268:Positron-Emission Tomography / Q000379:methods* / Q000706:statistics & numerical data; D019275:Radiopharmaceuticals
chemical_list: D005462:Fluorine Radioisotopes; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18