title: Pasteurella multocida sepsis, due to a scratch from a pet cat, in a post-chemotherapy neutropenic patient with non-Hodgkin lymphoma.
abstract: Pasteurella (P) multocida exists in a variety of animals and causes diverse infections in humans due to animal bites and scratches, usually by cats or dogs, and oral and respiratory infection. We report a case of P multocida sepsis due to a scratch from a pet cat, complicated with disseminated intravascular coagulation in a post-chemotherapy neutropenic patient with non-Hodgkin lymphoma. The patient was a febrile 79-year-old woman with disturbed consciousness and subcutaneous abscess in her right hand due to a scratch from a pet cat. She was successfully treated with empirical antibiotic therapy with cefepime and administrations of granulocyte colony-stimulating factor and danaparoid. The minimum inhibitory concentration of cefepime against the isolate from this case was <2mg/L. Although a few days are required before a diagnosis of P multocida infection can be made from a bacteriological study, the infection can be successfully treated against febrile neutropenia with empirical cefepime. In a literature review, 7 cases, including ours, with hematological malignancies complicated with P multocida infection were identified and we summarized the clinical characteristics of these cases. These cases demonstrate the importance of the prevention of close contact between pet animals and immunocompromised hosts such as post-chemotherapy neutropenic patients.
authors.affiliation: Department of Internal Medicine, Chiba Hokusoh Hospital, Nippon Medical School, Chiba, Japan. himitsu@nms.ac.jp
authors.forename: Norio
authors.initials: N
authors.lastname: Yokose
authors.forename: Kazuo
authors.initials: K
authors.lastname: Dan
mesh_terms: D000368:Aged; D000818:Animals; D000829:Animals, Domestic; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D000925:Anticoagulants / Q000008:administration & dosage*; D001733:Bites and Stings; D002415:Cats; D000077723:Cefepime; D002511:Cephalosporins / Q000008:administration & dosage*; D002809:Chondroitin Sulfates / Q000008:administration & dosage*; D003871:Dermatan Sulfate / Q000008:administration & dosage*; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage*; D006497:Heparan Sulfate / Q000008:administration & dosage*; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000150:complications / Q000188:drug therapy; D009503:Neutropenia / Q000209:etiology / Q000382:microbiology; D010326:Pasteurella Infections / Q000188:drug therapy* / Q000209:etiology; D016979:Pasteurella multocida; D018805:Sepsis / Q000188:drug therapy* / Q000209:etiology / Q000382:microbiology
chemical_list: D000900:Anti-Bacterial Agents; D000925:Anticoagulants; D000077723:Cefepime; D002511:Cephalosporins; D002809:Chondroitin Sulfates; D003871:Dermatan Sulfate; D016179:Granulocyte Colony-Stimulating Factor; D006497:Heparan Sulfate; C035838:danaparoid