title: Effect of rinsing with povidone-iodine on bacteraemia due to scaling: a randomized-controlled trial.
abstract: OBJECTIVE
  To investigate rinsing with povidone-iodine on bacteraemia caused by ultrasonic scaling.
  
  
  METHODS
  Sixty patients with gingivitis undertook a randomized, placebo-controlled trial in which 30 rinsed with 0.9% saline and 30 with 7.5% povidone-iodine for 2 min. before ultrasonic scaling of FDI teeth 31-35. Blood samples before and after 30 s and 2 min. of scaling were cultured by lysocentrifugation.
  
  
  RESULTS
  Oral bacteraemia occurred in 33.3% of the saline group and 10% of the povidone-iodine group. Regression analysis showed that rinsing with povidone-iodine was approximately 80% more effective than rinsing with saline in reducing the occurrence of bacteraemia, with a statistically significant odds ratio (OR) of 0.189 (95% confidence intervals, OR=0.043-0.827). There were 24 oral bacterial isolates in the saline group and 3 in the povidone-iodine group. Viridans streptococci comprised 11 of the isolates in the saline group and none in the povidone-iodine group. Bacteraemia magnitude was 0.1 colony-forming units/ml in the povidone-iodine subjects and 0.1-0.7 CFU/ml in the saline group.
  
  
  CONCLUSIONS
  Rinsing with 7.5% povidone-iodine reduced the incidence and magnitude of bacteraemia and eliminated viridans streptococci from such bacteraemia. Povidone-iodine rinsing may be helpful for ultrasonic scaling of gingivitis patients at risk of infective endocarditis.
authors.affiliation: Discipline of Periodontics, Faculty of Dentistry, University of Sydney, Sydney, Australia.
authors.forename: Martin
authors.initials: M
authors.lastname: Cherry
authors.forename: Christopher G
authors.initials: CG
authors.lastname: Daly
authors.forename: David
authors.initials: D
authors.lastname: Mitchell
authors.forename: John
authors.initials: J
authors.lastname: Highfield
mesh_terms: D000328:Adult; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage / Q000627:therapeutic use*; D016470:Bacteremia / Q000209:etiology / Q000517:prevention & control*; D003774:Dental Plaque Index; D003777:Dental Prophylaxis / Q000009:adverse effects; D012534:Dental Scaling / Q000009:adverse effects*; D005260:Female; D005891:Gingivitis / Q000150:complications / Q000628:therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D009067:Mouthwashes / Q000008:administration & dosage / Q000627:therapeutic use*; D011206:Povidone-Iodine / Q000008:administration & dosage / Q000627:therapeutic use*; D018709:Statistics, Nonparametric; D016896:Treatment Outcome
chemical_list: D000891:Anti-Infective Agents, Local; D009067:Mouthwashes; D011206:Povidone-Iodine