Amorphane sesquiterpenes from a marine Streptomyces sp.
The chemical investigation of the crude extract of the marine-derived Streptomyces sp. M491 yielded three new sesquiterpenes, namely, 10alpha,11-dihydroxyamorph-4-ene (4), 10alpha,15-dihydroxyamorph-4-en-3-one (6), and 5alpha,10alpha,11-trihydroxyamorphan-3-one (7). In addition, the known compounds 10alpha-hydroxyamorph-4-en-3-one (2), o-hydroxyacetanilide, genistein, prunetin, and indole-3-carbaldehyde and the macrolide antibiotic chalcomycin A were identified. The structures were determined on the basis of spectroscopic analysis, especially 1D and 2D NMR data. This is the first report of these sesquiterpenes from bacteria.
Wu
Shao Jie
SJ
Department of Organic and Biomolecular Chemistry, University of Göttingen, Tammannstrasse 2, D-37077 Göttingen, Germany.
Fotso
Serge
S
Li
Fuchao
F
Qin
Song
S
Laatsch
Hartmut
H
D001419:Bacteria / Q000187:drug effects; D002681:China; D005658:Fungi / Q000187:drug effects; D008386:Marine Biology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D013302:Streptomyces / Q000737:chemistry*
D012717:Sesquiterpenes