title: Mass spectrometric study of dirhenium biscarboxylate:purine dinucleotide complexes.
abstract: Dirhenium adducts of purine dinucleotides were identified by mass spectrometry. In consecutive studies, Re(2)(O(2)C(2)H(3))(2)Cl(4) . 2H(2)O was reacted with 2'-deoxyguanylyl(3'-->5')-2'-deoxyguanosine (dGpG) and 2'-deoxyadenylyl(3'-->5')-2'-deoxyguanosine (dApG) in H(2)O or D(2)O. These reactions were monitored to identify novel dinuclear rhenium:dinucleotide complexes as confirmed by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOFMS), electrospray ionization mass spectrometry (ESI-MS) and collision-induced dissociation tandem mass spectrometry (CID MS/MS) experiments. However, the most abundant adducts detected by ES-MS were dirhenium:nucleotide species. Of these, guanine-containing ions were observed with highest ion counts suggesting a preference for guanine coordination. Dimetal adducts showed coordination of the purine bases and common metalated fragments were observed for both dGpG and dApG reactions.
authors.affiliation: Chemistry Department, College of the Pacific, University of the Pacific, Stockton, CA 95211, USA. eday@pacific.edu
authors.forename: Elizabeth F
authors.initials: EF
authors.lastname: Day
authors.forename: Tiffany A
authors.initials: TA
authors.lastname: Payne
authors.forename: Crystal A
authors.initials: CA
authors.lastname: Holt
mesh_terms: D002853:Chromatography, Liquid / Q000379:methods*; D046911:Macromolecular Substances / Q000737:chemistry; D013058:Mass Spectrometry / Q000379:methods*; D008956:Models, Chemical; D008958:Models, Molecular; D008968:Molecular Conformation; D011685:Purine Nucleotides / Q000737:chemistry*; D012211:Rhenium / Q000737:chemistry*
chemical_list: D046911:Macromolecular Substances; D011685:Purine Nucleotides; D012211:Rhenium