title: Transplacental isopropanol exposure: case report and review of metabolic principles.
abstract: Isopropanol, a known central nervous system depressant has been reported to cause toxicity via multiple routes including ingestion, inhalation and dermal exposure. We present a case of transplacental isopropanol exposure in a neonate. A woman reported polysubstance abuse in the 1 to 2 days before precipitously delivering a newborn infant. The neonate developed hypotension, hypotonia and seizure activity within the first few hours of life. Blood samples from the infant revealed toxic levels of isopropanol. Similar symptoms have been reported in infants with isopropanol toxicity from other routes of exposure.
authors.affiliation: Division of General Pediatrics, Department of Pediatrics, The Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA. woodjo@email.chop.edu
authors.forename: J N
authors.initials: JN
authors.lastname: Wood
authors.forename: J
authors.initials: J
authors.lastname: Carney
authors.forename: K
authors.initials: K
authors.lastname: Szczepanski
authors.forename: D P
authors.initials: DP
authors.lastname: Calello
authors.forename: H
authors.initials: H
authors.lastname: Hurt
mesh_terms: D019840:2-Propanol / Q000378:metabolism / Q000506:poisoning*; D000096:Acetone / Q000097:blood; D000328:Adult; D020270:Alcohol Withdrawal Seizures; D002492:Central Nervous System Depressants / Q000378:metabolism / Q000506:poisoning*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000139:chemically induced*; D019966:Substance-Related Disorders / Q000150:complications / Q000378:metabolism
chemical_list: D002492:Central Nervous System Depressants; D000096:Acetone; D019840:2-Propanol