HIV-1 natural viral suppressors: control of viral replication in the absence of therapy.
The objective of this study was to identify and define a cohort of HIV-1-infected individuals with the ability to suppress HIV-1 replication naturally (patients with undetectable viral loads for at least 2 years without antiretroviral drugs). Proviral DNA ranged from one to 74 copies/10(6) peripheral blood mononuclear cells, with the mean value lower by 1-2 logs than long-term non-progressors. This ability to control HIV-1 viral replication naturally has led us to refer to them as natural viral suppressors.
Sajadi
Mohammad M
MM
Institute of Human Virology, University of Maryland, Baltimore, Maryland, USA.
Heredia
Alonso
A
Le
Nhut
N
Constantine
Neil T
NT
Redfield
Robert R
RR
D015331:Cohort Studies; D004279:DNA, Viral / Q000097:blood; D015658:HIV Infections / Q000821:virology*; D015497:HIV-1 / Q000502:physiology*; D006801:Humans; D011533:Proviruses / Q000502:physiology; D019562:Viral Load; D014779:Virus Replication
D004279:DNA, Viral