title: Sex specificity of ventral anterior cingulate cortex suppression during a cognitive task.
abstract: Ventral anterior cingulate cortex (vACC) is a highly interconnected brain region considered to reflect the sometimes competing demands of cognition and emotion. A reciprocal relationship between vACC and dorsal ACC (dACC) may play a role in maintaining this balance between cognitive and emotional processing. Using functional MRI in association with a cognitively-demanding visuospatial task (mental rotation), we found that only women demonstrated vACC suppression and inverse functional connectivity with dACC. Sex differences in vACC functioning--previously described under conditions of negative emotion--are extended here to cognition. Consideration of participant sex is essential to understanding the role of vACC in cognitive and emotional processing.
authors.affiliation: Functional Neuroimaging Laboratory, Department of Psychiatry, Weill Medical College of Cornell University, New York, NY 10021, USA. tab2006@med.cornell.edu
authors.forename: Tracy
authors.initials: T
authors.lastname: Butler
authors.forename: Julianne
authors.initials: J
authors.lastname: Imperato-McGinley
authors.forename: Hong
authors.initials: H
authors.lastname: Pan
authors.forename: Daniel
authors.initials: D
authors.lastname: Voyer
authors.forename: Amy Christine
authors.initials: AC
authors.lastname: Cunningham-Bussel
authors.forename: Luke
authors.initials: L
authors.lastname: Chang
authors.forename: Yuan-Shan
authors.initials: YS
authors.lastname: Zhu
authors.forename: Juan J
authors.initials: JJ
authors.lastname: Cordero
authors.forename: Emily
authors.initials: E
authors.lastname: Stern
authors.forename: David
authors.initials: D
authors.lastname: Silbersweig
mesh_terms: D000328:Adult; D001931:Brain Mapping; D003071:Cognition / Q000502:physiology*; D004644:Emotions / Q000502:physiology*; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006179:Gyrus Cinguli / Q000033:anatomy & histology / Q000502:physiology*; D006801:Humans; D007092:Imagination / Q000502:physiology; D008279:Magnetic Resonance Imaging; D008297:Male; D009415:Nerve Net / Q000033:anatomy & histology / Q000502:physiology; D009433:Neural Inhibition / Q000502:physiology; D009483:Neuropsychological Tests; D017397:Prefrontal Cortex / Q000033:anatomy & histology / Q000502:physiology*; D011597:Psychomotor Performance / Q000502:physiology; D012727:Sex Characteristics; D013028:Space Perception / Q000502:physiology