Scavenger receptor class B type I (SCARB1) c.1119C>T polymorphism affects postprandial triglyceride metabolism in men.
The scavenger receptor class B type I (SCARB1) is a cell surface glycoprotein that plays a key role in reverse cholesterol transport. A polymorphism in exon 8 (c.1119C>T) has been associated with fasting HDL- and LDL- cholesterol concentrations in Caucasian populations. This study evaluated whether this variant is associated with postprandial lipemia in 59 normolipidemic males. After an overnight fast, the subjects were given a single fat load comprising 60% of energy as fat, 15% as protein, and 25% as carbohydrate. Blood was drawn every hour from baseline to 6 h, then every 2.5 h until h 11. We measured plasma lipid concentrations including triglycerides (TG) in large and small triglyceride rich lipoprotein particles (TRL). Changes in postprandial small TRL TG differed among groups over time (Pgeno x time = 0.034) whereby TT and CT subjects maintained lower concentrations throughout most of the postprandial period compared with CC subjects. Significant differences occurred at h 1, 2, 4, and 5 (P < 0.05). Postprandial changes in large TRL TG (Pgeno x time = 0.923) or total TG (Pgeno x time = 0.529) did not differ by genotype. These results suggest that the c.1119C>T polymorphism is associated with a lower postprandial TG response in the smaller, partially catabolized lipoprotein fraction.
Tanaka
Toshiko
T
Nutrition and Genomics Laboratory, JM-USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA. toshiko.tanaka@tufts.edu
Delgado-Lista
Javier
J
Lopez-Miranda
Jose
J
Perez-Jimenez
Francisco
F
Marin
Carmen
C
Perez-Martinez
Pablo
P
Gomez
Purificacion
P
Ordovas
Jose M
JM
D000293:Adolescent; D000328:Adult; D000483:Alleles; D001483:Base Sequence; D017931:DNA Primers / Q000235:genetics; D004041:Dietary Fats / Q000008:administration & dosage; D005091:Exons; D005787:Gene Frequency; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D019518:Postprandial Period / Q000502:physiology; D051122:Scavenger Receptors, Class B / Q000235:genetics*; D014280:Triglycerides / Q000097:blood / Q000737:chemistry / Q000378:metabolism*; D044465:White People / Q000235:genetics
D017931:DNA Primers; D004041:Dietary Fats; D008055:Lipids; C495124:SCARB1 protein, human; D051122:Scavenger Receptors, Class B; D014280:Triglycerides