Cell surface dynamics of CFTR: the ins and outs.
Ganeshan et al. (Biochem Biophys. Acta 1173 (2007) 192-200) recent study documents the effect of N-WASP inhibition and actin cytoskeleton disruption on the constitutive internalization and recycling of the cystic fibrosis transmembrane conductance regulator (CFTR) channel. The results implicate the cytoskeleton network as a potential modulator of immobilized CFTR pool size at the plasma membrane and the recycling efficiency of endocytosed channel back to the cell surface.
Okiyoneda
Tsukasa
T
Hospital for Sick Children Research Institutes, Cell Biology, 555 University Av., Toronto, Ontario, Canada M5G 1X8.
Lukacs
Gergely L
GL
D000818:Animals; D019005:Cystic Fibrosis Transmembrane Conductance Regulator / Q000378:metabolism*; D003599:Cytoskeleton / Q000378:metabolism; D004705:Endocytosis; D006801:Humans; D008954:Models, Biological; D021381:Protein Transport
D019005:Cystic Fibrosis Transmembrane Conductance Regulator