title: Concise enantioselective synthesis of abscisic acid and a new analogue.
abstract: Short and high-yielding syntheses of enantiomerically pure (S)-(+) and (R)-(-)-abscisic acid are described. The syntheses proceed through key intermediates that preferentially recrystallise as single diastereoisomers for each enantiomer. This route allows the preparation of either enantiomer of abscisic acid in ca. 30% overall yield, and as demonstrated, gives access to an enantiomerically pure abscisic acid analogue.
authors.affiliation: Department of Chemistry, University of Warwick, Coventry, UK.
authors.forename: Timothy R
authors.initials: TR
authors.lastname: Smith
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Clark
authors.forename: Guy J
authors.initials: GJ
authors.lastname: Clarkson
authors.forename: Paul C
authors.initials: PC
authors.lastname: Taylor
authors.forename: Andrew
authors.initials: A
authors.lastname: Marsh
mesh_terms: D000040:Abscisic Acid / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry; D018360:Crystallography, X-Ray; D008958:Models, Molecular; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D000040:Abscisic Acid