title: Synthesis of urine drug metabolites: glucuronic acid glycosides of phenol intermediates.
abstract: The investigation of drug metabolism requires substantial amount of metabolites. Isolation from urine is tedious, therefore, the material obtained by synthesis is preferred. Substantial amounts of three tentative drug metabolites, phenolic glucuronides, have been prepared using easily available glycosyl donors. The final products [3(2-N-methyl-N-isopropylaminoethoxy)phenyl] beta-D-glucopyranosiduronic acid, 4-amino-3,5-dimethylphenyl beta-D-glucopyranosiduronic acid and [2(S)-propanoyl-6-O-naphthyl] beta-D-glucopyranuronic acid are useful as, for example, reference material in metabolite investigations.
authors.affiliation: Department of Chemistry, AstraZeneca, R&D Södertälje, S-151 85 Södertälje, Sweden.
authors.forename: Carl Johan
authors.initials: CJ
authors.lastname: Arewång
authors.forename: Martina
authors.initials: M
authors.lastname: Lahmann
authors.forename: Stefan
authors.initials: S
authors.lastname: Oscarson
authors.forename: Anna-Karin
authors.initials: AK
authors.lastname: Tidén
mesh_terms: D020723:Glucuronic Acid / Q000138:chemical synthesis* / Q000737:chemistry / Q000652:urine*; D006027:Glycosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000652:urine*; D015394:Molecular Structure; D010636:Phenols / Q000378:metabolism* / Q000652:urine
chemical_list: D006027:Glycosides; D010636:Phenols; D020723:Glucuronic Acid