Chemopreventive effects of sarcophine-diol on skin tumor development in CD-1 mice.
The objective of this study was to determine the chemopreventive effects of sarcophine-diol (SD) on 7,12-dimethylbenz(a)anthracene initiated and 12-O-tetradecanoylphorbol-13-acetate promoted skin tumor development in mice and its possible mechanisms of action. SD pretreatment significantly (P<0.05) decreased skin papilloma development during promotion phase. SD significantly (P<0.05) increased caspase-3 and decreased cyclooxygenase-2 during initiation phase or promotion phase. SD significantly (P<0.05) increased caspase-8 during promotion phase. SD resulted in a 95% reduction in 12-O-tetradecanoylphorbol-13-acetate-induced DNA synthesis. SD could be an effective chemopreventive agent for skin cancer by enhancing apoptosis and decreasing cell proliferation.
Zhang
Xiaoying
X
Department of Pharmaceutical Sciences, 1 Administration Lane, College of Pharmacy, Box 2202C, South Dakota State University, Brookings, SD 57007, USA.
Kundoor
Vipra
V
Khalifa
Sherief
S
Zeman
David
D
Fahmy
Hesham
H
Dwivedi
Chandradhar
C
D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000494:pharmacology; D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D002273:Carcinogens; D053148:Caspase 3 / Q000378:metabolism; D053181:Caspase 8 / Q000378:metabolism; D053453:Caspase 9 / Q000378:metabolism; D049109:Cell Proliferation / Q000187:drug effects; D051546:Cyclooxygenase 2 / Q000378:metabolism; D005260:Female; D051379:Mice; D010212:Papilloma / Q000139:chemically induced / Q000378:metabolism / Q000517:prevention & control*; D012878:Skin Neoplasms / Q000139:chemically induced / Q000378:metabolism / Q000517:prevention & control*; D013755:Tetradecanoylphorbol Acetate
D002273:Carcinogens; C014804:sarcophine; D015127:9,10-Dimethyl-1,2-benzanthracene; C077623:Ptgs2 protein, mouse; D051546:Cyclooxygenase 2; D053148:Caspase 3; D053181:Caspase 8; D053453:Caspase 9; D013755:Tetradecanoylphorbol Acetate; D015107:4-Butyrolactone