Prevention and treatment of Alzheimer disease and aging: antioxidants.
There is considerable evidence showing that oxidative damage is one of the earliest neuronal and pathological changes of Alzheimer disease and many, if not all, of the etiological and pathological causes of the disease are related, directly or indirectly, to free radical production and oxidative damage. Here we summarize the current body of knowledge suggestive that oxidative damage is, if not the key factor, certainly a major factor in Alzheimer disease. As such, therapeutic modalities encompassing antioxidants may be an effective approach to the treatment of neurodegenerative diseases and delay the aging process.
Liu
Quan
Q
Department of Ophthalmology, University of California-San Diego, 9500 Gilman Drive #0946, La Jolla, CA 92093-0946, USA. quliu@ucsd.edu
Xie
Fang
F
Rolston
Raj
R
Moreira
Paula I
PI
Nunomura
Akihiko
A
Zhu
Xiongwei
X
Smith
Mark A
MA
Perry
George
G
D000375:Aging / Q000187:drug effects* / Q000502:physiology*; D000544:Alzheimer Disease / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D006801:Humans; D018384:Oxidative Stress; D017382:Reactive Oxygen Species / Q000378:metabolism
D000975:Antioxidants; D017382:Reactive Oxygen Species