title: Association of HLA-DQA1*03011-DQB1*0301 haplotype with the development of respiratory scleroma.
abstract: OBJECTIVE
  Respiratory scleroma (RS) is a progressive, chronic, granulomatous disease caused by Klebsiella rhinoscleromatis. There is only one report of RS association with HLA-DQ3. In this study, molecular association of HLA class II and RS was determined.
  
  
  METHODS
  Nine RS patients and 163 healthy controls were compared. DQA1, DQB1, and DRB1 loci were typed.
  
  
  RESULTS
  Statistical analysis demonstrated association between DQB1*0301 and susceptibility to RS (P(c) = 0.004). Haplotype analysis showed an association of DQA1*03011-DQB1*0301 (P = 1.21E-19) and DRB1*0407-DQA1*03011-DQB1*0301 (P = 0.0002).
  
  
  CONCLUSIONS
  Results established that DQA1*03011-DQB1*0301 haplotype is a strong risk factor for development of RS.
authors.affiliation: División clínica de Otorhinolaryngology, Hospital General Dr. Manuel Gea González, SSA, México, DF, México.
authors.forename: Luis Alberto
authors.initials: LA
authors.lastname: Sánchez-Marín
authors.forename: Daniel
authors.initials: D
authors.lastname: Bross-Soriano
authors.forename: José
authors.initials: J
authors.lastname: Arrieta
authors.forename: Simón
authors.initials: S
authors.lastname: Kawa-Karasik
authors.forename: Víctor
authors.initials: V
authors.lastname: Martínez-Vilchis
authors.forename: Rocío
authors.initials: R
authors.lastname: Jiménez-Lucio
authors.forename: Angélica
authors.initials: A
authors.lastname: Olivo-Díaz
mesh_terms: D000328:Adult; D002874:Chromosome Mapping; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006683:HLA-DQ Antigens / Q000235:genetics*; D059848:HLA-DQ alpha-Chains; D059866:HLA-DQ beta-Chains; D006684:HLA-DR Antigens / Q000235:genetics; D059811:HLA-DRB1 Chains; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D012226:Rhinoscleroma / Q000235:genetics*; D012307:Risk Factors
chemical_list: D006683:HLA-DQ Antigens; D059848:HLA-DQ alpha-Chains; D059866:HLA-DQ beta-Chains; C069050:HLA-DQA1 antigen; C069051:HLA-DQB1 antigen; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains