title: HIV entry inhibition by the envelope 2 glycoprotein of GB virus C.
abstract: Epidemiological studies have revealed an association between GB virus C (GBV-C) long-term viraemia and ameliorated HIV disease progression. We have provided evidence that a single protein of GBV-C, the glycoprotein E2, interferes with early HIV replication steps of both X4- and R5-tropic HIV strains. Preincubation with anti-E2 antibody specifically abrogates the inhibitory effect. Results were confirmed by the in-vitro expression of GBV-C E1/E2 encoding RNA.
authors.affiliation: Institute of Clinical and Molecular Virology, University Hospital of the Friedrich-Alexander-Universität, Erlangen-Nuremberg, Germany.
authors.forename: Susan
authors.initials: S
authors.lastname: Jung
authors.forename: Melanie
authors.initials: M
authors.lastname: Eichenmüller
authors.forename: Norbert
authors.initials: N
authors.lastname: Donhauser
authors.forename: Frank
authors.initials: F
authors.lastname: Neipel
authors.forename: Alfred M
authors.initials: AM
authors.lastname: Engel
authors.forename: Georg
authors.initials: G
authors.lastname: Hess
authors.forename: Bernhard
authors.initials: B
authors.lastname: Fleckenstein
authors.forename: Heide
authors.initials: H
authors.lastname: Reil
mesh_terms: D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D029407:GB virus C / Q000502:physiology; D015658:HIV Infections / Q000821:virology*; D015497:HIV-1 / Q000502:physiology*; D006801:Humans; D011993:Recombinant Fusion Proteins / Q000494:pharmacology; D014162:Transfection; D014759:Viral Envelope Proteins / Q000235:genetics / Q000494:pharmacology / Q000502:physiology*; D014779:Virus Replication / Q000187:drug effects / Q000502:physiology*
chemical_list: D011993:Recombinant Fusion Proteins; D014759:Viral Envelope Proteins; C107619:glycoprotein E2, GB virus C