title: Controlled release of chlorhexidine diacetate from a porous methacrylate system: supercritical fluid assisted foaming and impregnation.
abstract: The release of chlorhexidine diacetate (CX) from a self-curing polymeric system based on poly(ethylmethacrylate) and tetrahydrofurfurylmethacrylate (PEM/THFM) was developed in this study. Supercritical fluid assisted impregnation and foaming was employed for preparing porous CX-PEM/THFM drug release system. X-ray diffraction (XRD) and differential scanning calorimetry (DSC) show that the crystallinity of CX significantly decreased after supercritical processing, whilst Raman spectroscopy suggested a hydrogen bonding interaction between the CX and PEM in the product. A UV-Vis dissolution study revealed that the drug release rate is almost as seven times faster in the SCF processed drug delivery system than conventional cured samples.
authors.affiliation: Clean Materials Technology Group, Department of Materials, Queen Mary University of London, Mile End Road, London E1 4NS, UK.
authors.forename: K
authors.initials: K
authors.lastname: Gong
authors.forename: M
authors.initials: M
authors.lastname: Braden
authors.forename: M P
authors.initials: MP
authors.lastname: Patel
authors.forename: I U
authors.initials: IU
authors.lastname: Rehman
authors.forename: Z
authors.initials: Z
authors.lastname: Zhang
authors.forename: J A
authors.initials: JA
authors.lastname: Darr
mesh_terms: D002152:Calorimetry, Differential Scanning; D002245:Carbon Dioxide; D002710:Chlorhexidine / Q000737:chemistry*; D003692:Delayed-Action Preparations / Q000737:chemistry*; D016503:Drug Delivery Systems / Q000379:methods; D006358:Hot Temperature; D006860:Hydrogen Bonding; D008689:Methacrylates / Q000737:chemistry*; D008768:Methylmethacrylates; D008855:Microscopy, Electron, Scanning; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry; D016062:Porosity; D011208:Powders; D013056:Spectrophotometry, Ultraviolet; D013059:Spectrum Analysis, Raman; D014961:X-Ray Diffraction
chemical_list: D003692:Delayed-Action Preparations; D008689:Methacrylates; D008768:Methylmethacrylates; D011108:Polymers; D011208:Powders; D002245:Carbon Dioxide; C009931:poly(ethylmethacrylate); D002710:Chlorhexidine