[Pulmonary metastases in children with solid tumours--own experiences].
BACKGROUND
The most frequent reasons of relapses in solid tumours among children are lung metastases.


OBJECTIVE
Analysis of lung metastatic cases among children with solid tumours treated from 1995-2005.


METHODS
26 lung metastatic cases (17 males, 9 females) were analysed. At the moment of the diagnosis lung metastases were present in 19.2% of patients while in the rest (80.8%) occurred during and after treatment. The most often lung metastases were recognised in osteosarcoma (15-57.8%) and carcinoma embryonale (3-11.6%). Secondary metastases in lungs occurred within 4-48 months after the diagnosis. In 57.7% were bilateral. 36 thoracotomies (average 1.7/ a child) were performed. The after-surgery chemotherapy for tumour recurrence was introduced in each case.


RESULTS
In the analysed group 14 (53.8%) children are alive with the overall survival time 8-120 months. The rest 12 (46.2%) are dead with the survival time 6-24 months. The statistically significant difference was found in comparison of complete surgery versus incomplete (p=0.02), no significance was found in primary or secondary metastases (p=0.27). Time of occurrence was statistically insignificant (p=0.26).


CONCLUSIONS
The occurrence of metastases in children solid tumours worsened the prognosis. The active search for lung metastases at the moment of diagnosis, treatment and follow-up combined with complete surgery procedures may prolong survival. There is a need to find new methods of lung metastases treatment.
Szumera
Małgorzata
M
Klinika Pediatrii, Gastroenterologii i Onkologii Dzieciecej, Akademia Medyczna, ul. Nowe Ogrody 1-6, 80-803 Gdańsk, Poland.
Czauderna
Piotr
P
Popadiuk
Stefan
S
Renke
Joanna
J
Sznurkowska
Katarzyna
K
Gołebiewski
Jacek
J
Korzon
Maria
M
D000293:Adolescent; D000328:Adult; D001859:Bone Neoplasms / Q000473:pathology / Q000601:surgery; D018236:Carcinoma, Embryonal / Q000556:secondary / Q000601:surgery; D006528:Carcinoma, Hepatocellular / Q000556:secondary / Q000601:surgery; D002648:Child; D004701:Endocrine Gland Neoplasms / Q000473:pathology / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology / Q000601:surgery; D008175:Lung Neoplasms / Q000453:epidemiology / Q000556:secondary* / Q000601:surgery*; D008297:Male; D009447:Neuroblastoma / Q000556:secondary / Q000601:surgery; D016522:Oncology Service, Hospital / Q000706:statistics & numerical data; D012516:Osteosarcoma / Q000556:secondary / Q000601:surgery; D011044:Poland; D011379:Prognosis; D012189:Retrospective Studies; D012512:Sarcoma, Ewing / Q000556:secondary / Q000601:surgery; D016896:Treatment Outcome