title: Cytotoxic 6-alkylsalicylic acids from the endophytic Streptomyces laceyi.
abstract: Two new 6-alkylsalicylic acids, salaceyins A and B were isolated by bioassay-guided fractionation from the culture of the endophytic Streptomyces laceyi MS53 and their structures were determined on the basis of spectroscopic data. Salaceyins A and B exhibited modest cytotoxicity against a human breast cancer cell line (SKBR3) with IC50 values of 3.0 and 5.5 microg/ml, respectively.
authors.affiliation: Division of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 136-713, Korea.
authors.forename: Nahyun
authors.initials: N
authors.lastname: Kim
authors.forename: Jin Chul
authors.initials: JC
authors.lastname: Shin
authors.forename: Woncheol
authors.initials: W
authors.lastname: Kim
authors.forename: Bang Yeon
authors.initials: BY
authors.lastname: Hwang
authors.forename: Beom Seok
authors.initials: BS
authors.lastname: Kim
authors.forename: Young-Soo
authors.initials: YS
authors.lastname: Hong
authors.forename: Dongho
authors.initials: D
authors.lastname: Lee
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D045744:Cell Line, Tumor; D006801:Humans; D012459:Salicylates / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013302:Streptomyces / Q000378:metabolism*
chemical_list: D000970:Antineoplastic Agents; D012459:Salicylates; C518209:salaceyin A; C518210:salaceyin B