Elevated rates of sister chromatid exchange at chromosome ends.
Chromosome ends are known hotspots of meiotic recombination and double-strand breaks. We monitored mitotic sister chromatid exchange (SCE) in telomeres and subtelomeres and found that 17% of all SCE occurs in the terminal 0.1% of the chromosome. Telomeres and subtelomeres are significantly enriched for SCEs, exhibiting rates of SCE per basepair that are at least 1,600 and 160 times greater, respectively, than elsewhere in the genome.
Rudd
M Katharine
MK
Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America.
Friedman
Cynthia
C
Parghi
Sean S
SS
Linardopoulou
Elena V
EV
Hsu
Li
L
Trask
Barbara J
BJ
D002877:Chromosomes, Human; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008954:Models, Biological; D008969:Molecular Sequence Data; D012854:Sister Chromatid Exchange; D016615:Telomere / Q000235:genetics*; D014407:Tumor Cells, Cultured