title: Copper(II) cyclam-based complexes for radiopharmaceutical applications: synthesis and structural analysis.
abstract: Two molecular structures of the copper(II) complex, Cu(H(2)TETA), have been determined by X-ray crystallography. The Jahn-Teller distortion differs between the two structures; occurring either along the axis of the pendant acetate arms or across the macrocyclic ring. An analysis of deposited data from over one hundred copper(II) cyclam X-ray structures in the Cambridge Structural Database (CSD) reveals that Jahn-Teller distortion across the ring is highly unusual for such compounds in the solid state. Novel chelators based on the piperazino/side-bridged cyclam have been prepared and copper(II) complexes formed. The single crystal X-ray structures of two copper(II) complexes, with either an ester or acid N-pendant arm, have been determined and in both cases the pendant arm is bound to the metal centre.
authors.affiliation: Department of Chemistry and Institute of Clinical Biosciences, The University of Hull, Cottingham Road, Hull, HU6 7RX, UK.
authors.forename: Jon D
authors.initials: JD
authors.lastname: Silversides
authors.forename: Cheryll C
authors.initials: CC
authors.lastname: Allan
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Archibald
mesh_terms: D003300:Copper / Q000737:chemistry*; D018360:Crystallography, X-Ray; D047029:Lactams, Macrocyclic / Q000138:chemical synthesis / Q000737:chemistry*; D008958:Models, Molecular; D008968:Molecular Conformation; D019275:Radiopharmaceuticals / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D047029:Lactams, Macrocyclic; D019275:Radiopharmaceuticals; D003300:Copper