Limited protection conferred by a DNA vaccine against a lethal pseudorabies virus infection at day 5 postvaccination.
No pseudorabies virus (PRV)-specific neutralizing or immunoglobulin G1-type antibodies were detected in sera 5 days after injection of a DNA vaccine against PRV infection in pigs. PRV-stimulated peripheral blood mononuclear cells produced gamma interferon mRNA in vitro. Two out of five pigs recovered from lethal PRV infection without attenuation of nasal viral excretion.
Dory
Daniel
D
Viral Genetics and Biosafety Unit, French Food Safety Agency (Afssa), Fr-22440 Ploufragan, France. d.dory@ploufragan.afssa.fr
Torché
Anne-Marie
AM
Béven
Véronique
V
Cariolet
Roland
R
Jestin
André
A
D000818:Animals; D011558:Herpesvirus 1, Suid / Q000276:immunology*; D007371:Interferon-gamma / Q000096:biosynthesis / Q000235:genetics; D011557:Pseudorabies / Q000276:immunology / Q000378:metabolism / Q000517:prevention & control*; D022421:Pseudorabies Vaccines / Q000276:immunology*; D012333:RNA, Messenger / Q000378:metabolism; D013552:Swine / Q000276:immunology / Q000378:metabolism / Q000821:virology; D013997:Time Factors; D019444:Vaccines, DNA / Q000276:immunology*
D022421:Pseudorabies Vaccines; D012333:RNA, Messenger; D019444:Vaccines, DNA; D007371:Interferon-gamma