Synthesis and biological evaluation of 7-azaindole derivatives, synthetic cytokinin analogues.
Cytokinins, N6-substituted adenine derivatives, are plant hormones playing important roles in various processes in plant development. Furthermore, cytokinins and their derivatives are able to control mammalian cell apoptosis and differentiation. The aim of our study was the synthesis of 7-azaindole derivatives as cytokinin analogues with the Hartwig-Buchwald coupling reaction in order to evaluate their biological properties on human myeloblastic leukaemia cells (HL-60 cell line). All these compounds presented a cytotoxic activity on HL-60 cells especially the 4-phenylaminopyrrolo[2,3-b]pyridine and the 4-phenethylaminopyrrolo[2,3-b]pyridine.
Guillard
Jérome
J
SPOT-EA3857, UFR des Sciences Pharmaceutiques, 31 Avenue Monge, 37200 Tours, France.
Decrop
Maÿlis
M
Gallay
Nathalie
N
Espanel
Claire
C
Boissier
Elodie
E
Herault
Olivier
O
Viaud-Massuard
Marie-Claude
MC
D001593:Benzyl Compounds / Q000737:chemistry; D002384:Catalysis; D002453:Cell Cycle; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D003583:Cytokinins / Q000737:chemistry* / Q000494:pharmacology*; D015195:Drug Design; D004354:Drug Screening Assays, Antitumor; D018922:HL-60 Cells; D006801:Humans; D007211:Indoles / Q000737:chemistry* / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D008956:Models, Chemical; D008968:Molecular Conformation; D011419:Propidium / Q000494:pharmacology; D011687:Purines / Q000737:chemistry
C023422:7-azaindole dimer; D001593:Benzyl Compounds; D003583:Cytokinins; D007211:Indoles; D011687:Purines; D011419:Propidium; C480551:benzylaminopurine