title: Enantioselective direct aldol reaction "on water" promoted by chiral organic catalysts.
abstract: [structure: see text]. 1,1'-Binaphthyl-2,2'-diamine-based (S)-prolinamides in the presence of stearic acid were able to promote the direct aldol condensation of cyclohexanone and other ketones with different aldehydes in the presence of a massive amount of water in very good yields, high diastereoselectivity, and up to 99% ee. The behavior of both C2- and C1-symmetric catalysts in combination with different additives was investigated, and a preliminary experiment of recovering and recycling of the catalytic system was also attempted.
authors.affiliation: Dipartimento di Chimica Organica e Industriale, Università degli Studi di Milano, Via Golgi 19, I-20133 Milano, Italy.
authors.forename: Stefania
authors.initials: S
authors.lastname: Guizzetti
authors.forename: Maurizio
authors.initials: M
authors.lastname: Benaglia
authors.forename: Laura
authors.initials: L
authors.lastname: Raimondi
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Celentano