title: High-dose methadone and QTc prolongation: strategies to optimize safety.
authors.affiliation: Clinical Pharmacology and Therapeutics Research Branch, Intramural Research Program, National Institute of Drug Abuse, National Institute of Health, Baltimore, Maryland, USA.
authors.forename: John
authors.initials: J
authors.lastname: Schmittner
authors.forename: Mori J
authors.initials: MJ
authors.lastname: Krantz
mesh_terms: D000328:Adult; D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D002908:Chronic Disease; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008133:Long QT Syndrome / Q000139:chemically induced*; D008691:Methadone / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D010146:Pain / Q000188:drug therapy* / Q000209:etiology
chemical_list: D000701:Analgesics, Opioid; D008691:Methadone