Neuroprotective effects of kobophenol A against the withdrawal of tropic support, nitrosative stress, and mitochondrial damage in SH-SY5Y neuroblastoma cells.
This study examined the neuroprotective effects of kobophenol A (kob A), oligomeric stillbene, and a resveratrol tetramer. Neuronal death induced by the withdrawal of tropic support was ameliorated by kob A. The protective effect of kob A against nitrosative/oxidative or mitochondrial damages resulted in the inhibition of the ROS, intracellular calcium ion level, and mitochondrial transmembrane potential changes on SH-SY5Y cells.
Lee
Sung Ryul
SR
College of pharmacy, Sungkyunkwan University, Suwon 440-746, Republic of Korea.
Kwak
Jong Hwan
JH
Kim
Hyoung Ja
HJ
Pyo
Suhkneung
S
D002118:Calcium / Q000378:metabolism; D045744:Cell Line, Tumor; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D015195:Drug Design; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007477:Ions; D008564:Membrane Potentials; D008928:Mitochondria / Q000378:metabolism*; D008956:Models, Chemical; D008968:Molecular Conformation; D009584:Nitrogen / Q000737:chemistry*; D010100:Oxygen / Q000737:chemistry; D013267:Stilbenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
D007477:Ions; D013267:Stilbenes; C510380:kobophenol A; D009584:Nitrogen; D010100:Oxygen; D002118:Calcium