title: Prognostic significance of stomatin-like protein 2 overexpression in laryngeal squamous cell carcinoma: clinical, histologic, and immunohistochemistry analyses with tissue microarray.
abstract: Stomatin-like protein 2 (SLP-2) is a novel cancer-related gene whose product promotes cell growth, tumorigenicity, and adhesion in human esophageal squamous cell carcinoma. The purpose of this study was to investigate whether SLP-2 is overexpressed in human laryngeal squamous cell carcinoma (LSCC) and, if so, the significance of its overexpression in relation to clinical parameters. By analyzing 124 cases of LSCC with a tissue microarray, we concluded that SLP-2 is overexpressed in LSCC as compared with the adjacent normal laryngeal epithelium (P = .000) and furthermore that SLP-2 expression correlates with clinical stage. Overexpression can be regarded as a significant prognostic factor, with higher expression being found in lymph node metastasis.
authors.affiliation: Department of Pathology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.
authors.forename: Wen-feng
authors.initials: WF
authors.lastname: Cao
authors.forename: Li-yong
authors.initials: LY
authors.lastname: Zhang
authors.forename: Ming-bo
authors.initials: MB
authors.lastname: Liu
authors.forename: Ping-zhang
authors.initials: PZ
authors.lastname: Tang
authors.forename: Zhi-hua
authors.initials: ZH
authors.lastname: Liu
authors.forename: Bao-cun
authors.initials: BC
authors.lastname: Sun
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D001798:Blood Proteins / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D007820:Laryngeal Mucosa / Q000378:metabolism; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000473:pathology; D008565:Membrane Proteins / Q000378:metabolism*; D011379:Prognosis; D046888:Tissue Array Analysis
chemical_list: D014408:Biomarkers, Tumor; D001798:Blood Proteins; D008565:Membrane Proteins; C406287:STOML2 protein, human