title: Effect of stimulus-driven pruning on the detection of spatiotemporal patterns of activity in large neural networks.
abstract: Adult patterns of neuronal connectivity develop from a transient embryonic template characterized by exuberant projections to both appropriate and inappropriate target regions in a process known as synaptic pruning. Trigger signals able to induce synaptic pruning could be related to dynamic functions that depend on the timing of action potentials. We stimulated locally connected random networks of spiking neurons and observed the effect of a spike-timing-dependent synaptic plasticity (STDP)-driven pruning process on the emergence of cell assemblies. The spike trains of the simulated excitatory neurons were recorded. We searched for spatiotemporal firing patterns as potential markers of the build-up of functionally organized recurrent activity associated with spatially organized connectivity.
authors.affiliation: Inserm, U318, Laboratoire de Neurobiophysique, Université Joseph Fourier, Grenoble 1, CHU Michallon Pavillon B, BP 217, F-38043 Grenoble Cedex, France. Javier.Iglesias@unil.ch
authors.forename: Javier
authors.initials: J
authors.lastname: Iglesias
authors.forename: Alessandro E P
authors.initials: AE
authors.lastname: Villa
mesh_terms: D000200:Action Potentials; D008959:Models, Neurological; D009415:Nerve Net; D009473:Neuronal Plasticity