title: [Clinical evaluation of the efficacy and tolerability of the ''NoAll Bimbi Pasta Trattante'' barrier cream in napkin dermatitis].
abstract: OBJECTIVE
  Napkin dermatitis or diaper dermatitis is one of the most frequent cutaneous disease in the pediatric age. The most common type of napkin dermatitis is the irritant contact form, which is frequently complicated by an overinfection with bacteria or Candida albicans.
  
  
  METHODS
  In this paper, 25 children (7 males and 18 females), aged between 1 month and 4 years and affected by napkin dermatitis, were treated with a barrier cream containing zinc oxide, vitamin E, panthenol (NoAll Bimbi Pasta Trattante, PSN Rottapharm, Milan, Italy). In 20 patients, a diagnosis of irritant contact diaper dermatitis was made, 3 patients suffered from atopic dermatitis, 1 patient was affected by psoriasis and 1 patient presented to a perianal streptococcal dermatitis. A candidal overinfection was diagnosed in 12 patients and was treated with a topical antifungal agent, applied twice daily for 2 weeks. NoAll Bimbi Pasta Trattante was applied at every diaper change. In all cases, we considered 2 subjective symptoms (burning and itching), and 3 objective parameters (erythema, oedema, exudation/vesiculation), at baseline and after 4 weeks of treatment.
  
  
  RESULTS
  One patient withdrew the study. In 13 patients clinical healing was observed, 9 patients showed marked improvement, in 2 patients we did not observe improvement. Tolerability was considered excellent in 13 patients, good in 9 and sufficient in 2.
  
  
  CONCLUSIONS
  The results obtained demonstrated that NoAll Bimbi Pasta Trattante, applied at every change of the napkin, is very effective and well tolerated in the treatment of irritant diaper dermatitis. Moreover, NoAll Bimbi Pasta Trattante, applied in association with other pharmacological treatments, may accelerate healing in case of overinfection due to Candida albicans and in case of inflammatory dermatoses localized in the gluteo-perineal area.
authors.affiliation: Sezione di Clinica Dermatologica, Dipartimento di Medicina Clinica, Specialistica e Sperimentale, Università degli Studi di Bologna, Bologna, Italy. annalisa.patrizi@unibo.it
authors.forename: A
authors.initials: A
authors.lastname: Patrizi
authors.forename: I
authors.initials: I
authors.lastname: Neri
authors.forename: E
authors.initials: E
authors.lastname: Varotti
authors.forename: B
authors.initials: B
authors.lastname: Raone
mesh_terms: D000287:Administration, Topical; D002176:Candida albicans / Q000302:isolation & purification; D002675:Child, Preschool; D003876:Dermatitis, Atopic / Q000188:drug therapy; D003963:Diaper Rash / Q000188:drug therapy* / Q000453:epidemiology* / Q000382:microbiology; D004338:Drug Combinations; D004342:Drug Hypersensitivity / Q000175:diagnosis / Q000453:epidemiology*; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D010205:Pantothenic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D013291:Streptococcus / Q000302:isolation & purification; D014810:Vitamin E / Q000008:administration & dosage / Q000627:therapeutic use*; D015034:Zinc Oxide / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D004338:Drug Combinations; D014810:Vitamin E; D010205:Pantothenic Acid; C007288:dexpanthenol; D015034:Zinc Oxide