title: Heat shock protein 72 (HSPA1B) gene polymorphism and Toll-like receptor (TLR) 4 mutation are associated with increased risk of urinary tract infection in children.
abstract: Innate immunity and urinary tract response play a central role in the development of urinary tract infection (UTI). Heat shock protein (HSP) 72 and Toll-like receptor (TLR) 4 are among the key elements of innate defence mechanisms. This study assesses the role of HSPA1B A(1267)G and TLR4 A(896)G polymorphisms using allele-specific polymerase chain reaction in 103 patients treated with recurrent UTI. Allelic prevalence was compared with reference values of 235 healthy controls. Clinical data were also statistically evaluated. TLR4 (896)AG genotype and TLR4 (896)G allele had also higher prevalence in UTI patients versus controls (p = 0.031 and 0.041, respectively). Our data indicates a relationship between the carrier status of HSPA1B (1267)G and TLR4 (896)G alleles and the development of recurrent UTI in childhood independently of other renal abnormalities, while raising further questions about the clinical and therapeutic relevance of these polymorphisms in everyday pediatric nephrology.
authors.affiliation: Hetényi Géza Hospital, Szolnok, H-5004 Hungary.
authors.forename: Eva
authors.initials: E
authors.lastname: Karoly
authors.forename: Andrea
authors.initials: A
authors.lastname: Fekete
authors.forename: Nora F
authors.initials: NF
authors.lastname: Banki
authors.forename: Beata
authors.initials: B
authors.lastname: Szebeni
authors.forename: Adam
authors.initials: A
authors.lastname: Vannay
authors.forename: Attila J
authors.initials: AJ
authors.lastname: Szabo
authors.forename: Tivadar
authors.initials: T
authors.lastname: Tulassay
authors.forename: Georg S
authors.initials: GS
authors.lastname: Reusz
mesh_terms: D000483:Alleles; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D005838:Genotype; D050884:HSP72 Heat-Shock Proteins / Q000235:genetics*; D006579:Heterozygote; D006801:Humans; D007113:Immunity, Innate; D008297:Male; D009154:Mutation; D011110:Polymorphism, Genetic; D012008:Recurrence; D051197:Toll-Like Receptor 4 / Q000235:genetics*; D014552:Urinary Tract Infections / Q000209:etiology / Q000235:genetics* / Q000276:immunology*
chemical_list: D050884:HSP72 Heat-Shock Proteins; C495345:TLR4 protein, human; D051197:Toll-Like Receptor 4