title: [Lysophosphatidic acid promotes transplanted tumor growth of human epithelium ovarian cancer in nude mice].
abstract: OBJECTIVE
  To investigate effect of lysophosphatidic acid (LPA) on growth and metastasis of intraperitonally transplanted tumor in nude mice.
  
  
  METHODS
  Sixteen nude mice randomly divided into control group and LPA treatment group, in which 6x10(6) untreated and LPA-treated human ovarian cancer cells skov3 were respectively transplanted intraperitoneally. After death of the nude mice without interventions, the weight of the transplanted tumors and number of metastatic tumors were recorded.
  
  
  RESULTS
  The rate of tumor formation was 100%in both groups, but the treatment group showed more rapid tumor growth, greater tumor weight and more numerous metastatic tumors than the control group (P<0.01).
  
  
  CONCLUSIONS
  LPA simulates the growth and promotes invasiveness of transplanted ovarian cancer cells in the peritoneal cavity of nude mie.
authors.affiliation: Department of Gynecology, Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China. weihui1973@163.com
authors.forename: Hui
authors.initials: H
authors.lastname: Wang
authors.forename: Xiao-Hua
authors.initials: XH
authors.lastname: Wu
authors.forename: Li
authors.initials: L
authors.lastname: Shi
mesh_terms: D000818:Animals; D005260:Female; D008246:Lysophospholipids / Q000633:toxicity*; D051379:Mice; D008819:Mice, Nude; D009361:Neoplasm Invasiveness; D009368:Neoplasm Transplantation; D010051:Ovarian Neoplasms / Q000473:pathology*; D010534:Peritoneal Neoplasms / Q000139:chemically induced / Q000556:secondary*; D011897:Random Allocation; D014183:Transplantation, Heterologous; D047368:Tumor Burden / Q000187:drug effects
chemical_list: D008246:Lysophospholipids; C032881:lysophosphatidic acid