title: Splenic focal lesions as manifestation of sarcoidosis: Characterization with contrast-enhanced sonography.
abstract: We report the case of a 74-year-old woman with elevated liver enzyme levels in whom abdominal sonographic examination revealed a diffusely heterogeneous liver parenchyma and multiple hypoechoic subcentimetric splenic nodules. Contrast-enhanced sonography (CEUS) revealed that the splenic focal lesions did not enhance. CT examination revealed a low-density, multinodular pattern both in the liver and in the spleen. Core biopsy of 1 hepatic nodule revealed noncaseating epithelioid cell granuloma, and the patient was diagnosed with systemic sarcoidosis. CEUS has shown to be useful in the diagnosis of focal hepatic lesions, but studies referring to splenic lesions are lacking.
authors.affiliation: Department of Gastroenterology, Virgen de la Salud Hospital, Avda Barber no. 30, Toledo 45004, Spain.
authors.forename: María José
authors.initials: MJ
authors.lastname: Pérez-Grueso
authors.forename: Alejandro
authors.initials: A
authors.lastname: Repiso
authors.forename: Rafael
authors.initials: R
authors.lastname: Gómez
authors.forename: Concepción
authors.initials: C
authors.lastname: Gonzalez
authors.forename: Tomás
authors.initials: T
authors.lastname: de Artaza
authors.forename: Julio
authors.initials: J
authors.lastname: Valle
authors.forename: Almudena
authors.initials: A
authors.lastname: García
authors.forename: Jose María
authors.initials: JM
authors.lastname: Carrobles
mesh_terms: D000368:Aged; D000469:Alkaline Phosphatase / Q000097:blood; D001706:Biopsy; D001799:Blood Sedimentation; D002097:C-Reactive Protein; D003287:Contrast Media / Q000008:administration & dosage*; D003920:Diabetes Mellitus; D003937:Diagnosis, Differential; D015622:Epithelioid Cells / Q000473:pathology; D005260:Female; D006099:Granuloma / Q000150:complications / Q000175:diagnosis; D006801:Humans; D006949:Hyperlipidemias / Q000150:complications; D007089:Image Enhancement / Q000379:methods; D008099:Liver / Q000000981:diagnostic imaging / Q000473:pathology; D010743:Phospholipids; D012507:Sarcoidosis / Q000150:complications / Q000175:diagnosis*; D013154:Spleen / Q000000981:diagnostic imaging*; D013158:Splenic Diseases / Q000175:diagnosis*; D013459:Sulfur Hexafluoride; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography; D005723:gamma-Glutamyltransferase / Q000097:blood
chemical_list: D003287:Contrast Media; D010743:Phospholipids; C420843:contrast agent BR1; D002097:C-Reactive Protein; D005723:gamma-Glutamyltransferase; D000469:Alkaline Phosphatase; D013459:Sulfur Hexafluoride