title: Biological active macrocyclic diterpenoids from chinese drug "Fáng Féng Cáo"; II. Derivatives of ovatodiolids and their cytotoxity.
abstract: Isolated macrocyclic diterpenoids, ovatodiolide ( 1), 4, 5-epoxyovatodiolide ( 2), anisomelic acid ( 3), 4, 7-oxycycloanisomelic acid ( 4), and 4-methylene-5-oxoanisomelic acid ( 6), from the Chinese crude drug "Fáng Féng Cáordquo;, and the derivatives of the isolated compounds were tested for their growth inhibiting activities in culture of KB cell line. Besides, the effects of 1 on Ehrlich carcinoma in mice are reported.
authors.affiliation: Department of Medicinal Resources, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930-01, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Arisawa
authors.forename: M
authors.initials: M
authors.lastname: Nimura
authors.forename: A
authors.initials: A
authors.lastname: Fujita
authors.forename: T
authors.initials: T
authors.lastname: Hayashi
authors.forename: N
authors.initials: N
authors.lastname: Morita
authors.forename: S
authors.initials: S
authors.lastname: Koshimura