title: Synthesis of symmetrical and unsymmetrical PAMAM dendrimers by fusion between azide- and alkyne-functionalized PAMAM dendrons.
abstract: A new convergent synthetic method for the synthesis of PAMAM dendrimers has been developed. The fusion between propargyl-functionalized PAMAM dendrons and azido-functionalized PAMAM dendrons via the Cu(I)-catalyzed Huisgen [2 + 3] dipolar cycloaddition reaction (click chemistry) of an alkyne and an azide leads to the formation of symmetric PAMAM dendrimers in high yields. Furthermore, the coupling reactions between the different generation dendrons afford the size-differentiated unsymmetrical PAMAM dendrimers.
authors.affiliation: Department of Chemistry, Dong-A University, Hadan-2-dong, Busan 604-714, Korea. jlee@donga.ac.kr
authors.forename: Jae Wook
authors.initials: JW
authors.lastname: Lee
authors.forename: Jung Hwan
authors.initials: JH
authors.lastname: Kim
authors.forename: Hee Joo
authors.initials: HJ
authors.lastname: Kim
authors.forename: Seung Choul
authors.initials: SC
authors.lastname: Han
authors.forename: Ji Hyeon
authors.initials: JH
authors.lastname: Kim
authors.forename: Won Suk
authors.initials: WS
authors.lastname: Shin
authors.forename: Sung-Ho
authors.initials: SH
authors.lastname: Jin
mesh_terms: D000480:Alkynes / Q000737:chemistry* / Q000378:metabolism; D001386:Azides / Q000737:chemistry* / Q000378:metabolism; D001672:Biocompatible Materials / Q000138:chemical synthesis* / Q000378:metabolism; D003500:Cyclization; D050091:Dendrimers / Q000737:chemistry* / Q000378:metabolism; D013058:Mass Spectrometry; D015394:Molecular Structure; D011073:Polyamines / Q000138:chemical synthesis* / Q000378:metabolism; D011108:Polymers / Q000737:chemistry* / Q000378:metabolism; D013499:Surface Properties
chemical_list: D000480:Alkynes; D001386:Azides; D001672:Biocompatible Materials; D050091:Dendrimers; C104700:PAMAM Starburst; D011073:Polyamines; D011108:Polymers