title: Combined antiherpetic effect of complex preparation "Viferon-eye drops" and modified nucleosides.
abstract: Ready dosage form (eye drops) prepared on the basis of recombinant alpha2-IFN exhibits high activity towards herpes simplex type 1 virus in vitro. Systematic study of the antiherpesvirus effect of this drug in combination with modified nucleosides showed an inhibitory effect of the synergic type. Combination of IFN preparation with some nucleosides, including ribavirin, proved to be highly effective towards drug-resistant herpes virus.
authors.affiliation: N. F. Gamaleya Institute of Epidemiology and Microbiology, Russian Academy of Medical Sciences. evizhlova@yandex.ru
authors.forename: E N
authors.initials: EN
authors.lastname: Vyzhlova
authors.forename: V L
authors.initials: VL
authors.lastname: Andronova
authors.forename: G A
authors.initials: GA
authors.lastname: Galegov
authors.forename: V V
authors.initials: VV
authors.lastname: Malinovskaya
mesh_terms: D000212:Acyclovir; D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D002522:Chlorocebus aethiops; D004305:Dose-Response Relationship, Drug; D015774:Ganciclovir; D018259:Herpesvirus 1, Human / Q000187:drug effects*; D007065:Idoxuridine; D020128:Inhibitory Concentration 50; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000494:pharmacology; D009705:Nucleosides / Q000494:pharmacology; D009883:Ophthalmic Solutions / Q000737:chemistry / Q000494:pharmacology*; D011994:Recombinant Proteins; D012254:Ribavirin; D013045:Species Specificity; D014709:Vero Cells; D014740:Vidarabine
chemical_list: D000998:Antiviral Agents; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D009705:Nucleosides; D009883:Ophthalmic Solutions; D011994:Recombinant Proteins; D012254:Ribavirin; D014740:Vidarabine; D007065:Idoxuridine; D015774:Ganciclovir; D000212:Acyclovir