title: Synthesis of soluble multivalent glycoconjugates that target the Hc region of botulinum neurotoxin A.
abstract: The design, synthesis, and initial inhibitory studies of di- and tetravalent glycoconjugates that target the heavy chain of botulinum neurotoxin A are reported.
authors.affiliation: 301 Clifton Court, Department of Chemistry, University of Cincinnati, Cincinnati, OH 45221, USA.
authors.forename: Ramesh R
authors.initials: RR
authors.lastname: Kale
authors.forename: Colin M
authors.initials: CM
authors.lastname: Clancy
authors.forename: Rebecca M
authors.initials: RM
authors.lastname: Vermillion
authors.forename: Eric A
authors.initials: EA
authors.lastname: Johnson
authors.forename: Suri S
authors.initials: SS
authors.lastname: Iyer
mesh_terms: D015153:Blotting, Western; D019274:Botulinum Toxins, Type A / Q000037:antagonists & inhibitors* / Q000737:chemistry; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D003014:Clostridium botulinum / Q000378:metabolism; D019281:Dimerization; D015195:Drug Design; D006001:Glycoconjugates / Q000737:chemistry*; D008024:Ligands; D008956:Models, Chemical; D008968:Molecular Conformation; D012995:Solubility
chemical_list: D006001:Glycoconjugates; D008024:Ligands; D019274:Botulinum Toxins, Type A