title: [Recombinant factor VII (NovoSeven) in intraoperative blood saving during neurosurgical treatment of the brain arteriovenous malformation].
abstract: BACKGROUND
  Cerebral arteriovenous (AV) malformation causes, due to the increased blood flow through a malformation, a massive intraoperative bleeding complicating, so, surgical treatment. The use of intraoperative blood saving apparatus during surgery and a recombinant factor VII-a (NovoSeven) significantly reduce complications during surgical treatment.
  
  
  METHODS
  We reported a case of surgical treatment of the patient with AV malformation of IV stage according to the Spetzler-Martin scale, in the brain. Due to a possible heavy bleeding we used a apparatus for intrasurgical blood recovery, Cell Saver, Sequestra 1 000, Medtronic, U.S.A., and recombinant human factor VIIa (rFVIIa--NovoSeven, NovoNordisk, Denmark) to control bleeding and restore an adequate hemostasis.
  
  
  CONCLUSIONS
  The use of an apparatus for intraoperative blood saving, as well as the NovoSeven preparation in the management of AV malformation of IV stage, showed to be successful.
authors.affiliation: Klinicki centar Nis, Neurohirurska klinika, Bulevar Zorana Dindića 48, 18 000 Nis, Srbija.
authors.forename: Vesna
authors.initials: V
authors.lastname: Novak
authors.forename: Budimir
authors.initials: B
authors.lastname: Petrović
authors.forename: Branko
authors.initials: B
authors.lastname: Calija
authors.forename: Ljiljana
authors.initials: L
authors.lastname: Mitov
authors.forename: Zoran
authors.initials: Z
authors.lastname: Rancić
mesh_terms: D000328:Adult; D016063:Blood Loss, Surgical / Q000517:prevention & control*; D001804:Blood Transfusion, Autologous; D005167:Factor VII / Q000008:administration & dosage*; D015942:Factor VIIa; D006488:Hemostasis, Surgical; D006490:Hemostatics / Q000008:administration & dosage*; D006801:Humans; D002538:Intracranial Arteriovenous Malformations / Q000601:surgery*; D008297:Male; D011994:Recombinant Proteins / Q000008:administration & dosage
chemical_list: D006490:Hemostatics; D011994:Recombinant Proteins; D005167:Factor VII; C103587:recombinant FVIIa; D015942:Factor VIIa