title: [Measurement of activated clotting time during cardiopulmonary bypass in infective endocarditis patients].
abstract: OBJECTIVE
  To investigate the proper dosage of heparin and protamin in treating the patients with infective endocarditis (IE) during the operation.
  
  
  METHODS
  Activated clotting time (ACT) was measured during and after cardiopulmonary bypass (CPB) in 30 patients with IE and 30 patients with rheumatic heart disease (RHD) respectively.
  
  
  RESULTS
  The dosage of heparin before bypass in IE group was significantly higher than that of RHD group (P<0.05); the dosage of protamin for neutralization after bypass in IE group was significantly higher than that of RHD group (P<0.05); the ratio of protamin and heparin were 0.76 +/-0.23 in IE group and 0.74 +/-0.12 in RHD group (P>0.05).
  
  
  CONCLUSIONS
  The dosage of protamin should be increased to 3 mg/kg as the heparin is over 400 U/kg before CPB in the patient with IE, but the ratio of protamin and heparin will not be obviously changed.
authors.affiliation: Department of Cardiothoracic Suergery, Second Xiangya Hospital, Central South University, Changsha 410011, China. zxb960@sohu.com
authors.forename: Ling
authors.initials: L
authors.lastname: Jiang
authors.forename: Jie-Feng
authors.initials: JF
authors.lastname: Yu
mesh_terms: D000328:Adult; D000925:Anticoagulants / Q000627:therapeutic use; D002315:Cardiopulmonary Bypass; D004305:Dose-Response Relationship, Drug; D016903:Drug Monitoring / Q000379:methods; D004696:Endocarditis / Q000601:surgery*; D005260:Female; D006493:Heparin / Q000627:therapeutic use*; D006494:Heparin Antagonists / Q000627:therapeutic use; D006801:Humans; D007430:Intraoperative Care / Q000379:methods; D008297:Male; D008875:Middle Aged; D011479:Protamines / Q000627:therapeutic use*; D014914:Whole Blood Coagulation Time
chemical_list: D000925:Anticoagulants; D006494:Heparin Antagonists; D011479:Protamines; D006493:Heparin