[Genetic background of multifactorial liver and bile duct diseases].
The majority of liver diseases, are complex. They are the results of interactions between several genes and environmental factors. Familial aggregation and higher concordance rate of monozygotic twins compared to those of dizygotic twins provide evidence for the importance of genetic factors in the pathogenesis. There are only limited data in connection with the genetic background of multifactorial liver diseases. In the future, the genetic background may permit prevention, early, accurate diagnosis, prediction of disease course, complications, prognosis, as well as treatment response.
Hagymási
Krisztina
K
Semmelweis Egyetem, Altalános Orvostudományi Kar II. Belgyógyászati Klinika Budapest Szentkirályi u. 46. hagymasikriszti@freemail.hu
Tulassay
Zsolt
Z
D001649:Bile Duct Diseases / Q000209:etiology / Q000235:genetics*; D015209:Cholangitis, Sclerosing / Q000235:genetics; D002769:Cholelithiasis / Q000235:genetics; D005805:Genes, MHC Class I; D005802:Genes, MHC Class II; D006801:Humans; D008103:Liver Cirrhosis / Q000235:genetics; D008105:Liver Cirrhosis, Biliary / Q000235:genetics; D008107:Liver Diseases / Q000209:etiology / Q000235:genetics*; D008108:Liver Diseases, Alcoholic / Q000235:genetics; D011110:Polymorphism, Genetic