Plasmodium yoelii: influence of antimalarial treatment on acquisition of immunity in BALB/c and DBA/2 mice.
The effect of antimalarial drugs on immune responses to the malaria infection is evaluated in vivo using two experimental self-cured rodent models. BALB/c and DBA/2 mice were infected by Plasmodium yoelii 17XNL and 17XL strains, respectively, and then treated with different doses of antimalarial drugs: chloroquine (228mg/kg or 114mg/kg of the body weight) or artesunate (78mg/kg or 39mg/kg). The effect of antimalarial drugs on host immune responses was evaluated by parasitemia, splenocyte IFN-gamma production level, and parasite-specific IgG level in the serum, however, no significant differences were observed between drug-treated and untreated groups. Moreover, most of the infected mice of all groups showed the ability to resist homologous reinfection (challenged on day 60 post-infection), only a few mice experienced transient, low parasitemia. The rechallenged mice were accompanied by high level of parasite-specific IgG. Therefore, this research implicated that, for BALB/c and DBA/2 mice, chloroquine or artesunate treatment of blood-stage P. yoelii infections does not compromise acquired immunity to malaria in either primary infection or upon rechallenge.
Ma
Shi-Hong
SH
Department of Immunology, College of Basic Medical Sciences, China Medical University, Heping District, Shenyang, China.
Zheng
Li
L
Liu
Ying-Jie
YJ
Guo
Sheng-Yu
SY
Feng
Hui
H
Chen
Guang
G
Li
Dong-Mei
DM
Wang
Ji-Chun
JC
Cao
Ya-Ming
YM
D000818:Animals; D000913:Antibodies, Protozoan / Q000096:biosynthesis / Q000097:blood; D000962:Antimalarials / Q000494:pharmacology*; D037621:Artemisinins / Q000494:pharmacology*; D000077332:Artesunate; D002738:Chloroquine / Q000494:pharmacology*; D005260:Female; D007074:Immunoglobulin G / Q000096:biosynthesis / Q000097:blood; D007371:Interferon-gamma / Q000032:analysis; D008288:Malaria / Q000188:drug therapy* / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D008811:Mice, Inbred DBA; D018512:Parasitemia / Q000188:drug therapy / Q000276:immunology / Q000469:parasitology; D010967:Plasmodium yoelii / Q000187:drug effects* / Q000276:immunology; D012008:Recurrence; D012717:Sesquiterpenes / Q000494:pharmacology*
D000913:Antibodies, Protozoan; D000962:Antimalarials; D037621:Artemisinins; D007074:Immunoglobulin G; D012717:Sesquiterpenes; D000077332:Artesunate; D007371:Interferon-gamma; D002738:Chloroquine