New targets for putative neuroprotective agents.
A better understanding of intracellular pathways engaged in the neuronal cell death afforded us new targets for developing putative neuroprotectants. Also pharmacological or genomic intervention aimed to modulate the expression of endogenous neuroprotective or toxic agents is a very promising strategy. Taking into account enormous complexity of biochemical cascades involved in neurodegenerative processes, multipotential or combined pharmacological approaches seem to be more efficient in combating degenerative brain diseases. Moreover, an improved cell transplantation also adds to a plethora of methods, which are used to afford neuroprotection and promote neurorestoration. All those strategies are reviewed in the presented article.
Jantas-Skotniczna
Danuta
D
Department of Experimental Neuroendocrinology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, 31-343 Kraków, Poland.
Kajta
Małgorzata
M
Lasoń
Władysław
W
D016923:Cell Death / Q000187:drug effects; D017690:Cell Transplantation; D016503:Drug Delivery Systems / Q000379:methods; D004359:Drug Therapy, Combination; D006801:Humans; D019636:Neurodegenerative Diseases / Q000628:therapy*; D018696:Neuroprotective Agents / Q000494:pharmacology*
D018696:Neuroprotective Agents