[The expression of tumor necrosis factor related apoptosis induce ligand in human laryngeal squamous cell carcinoma].
OBJECTIVE
To study the expression of tumor necrosis factor related apoptosis induce ligand (TRAIL) receptors (DR4, DR5, DcR1, DcR2) in human laryngeal squamous cell carcinoma (LSCC).


METHODS
The expression and distribution of DR4, DR5, DcR1, DcR2 were detected by immunohistochemical method in 68 patients of LSCC and 40 laryngeal normal tissues (LNT).


RESULTS
All of TRAIL receptors was observed in both tissues of LSCC and LNT. It was found that DR4, DR5 were overexpressed in the two tissues, indicating that there were no significant difference between the expressions of DR4 and DR5 in two tissues (P >0.05). DcR1 , DcR2 were over-expressed in LNT,were low expressed in LSCC (P <0. 05). Level of the TRAIL receptors DR5, DcR2 related with the degree of LSCC histological differentiation (P <0. 05). All receptors were not related with different clinical stage (P >0.05).


CONCLUSIONS
TRAIL receptors expression is generally expressed in human LSCC and LNT. The expression level of TRAIL receptors is various, which may explain the anti-cancer effect of TRAIL. The TRAIL receptor DcR1, DcR2 may play an important role in the apoptosis regulation of LSCC.
Yao
Hongchao
H
Department of Otolaryngology, the Second Affiliated Hospital of China Medical University, Shenyang, 110001, China.
Ji
Wenyue
W
Guan
Chao
C
Liu
Bin
B
D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D016022:Case-Control Studies; D006801:Humans; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000473:pathology; D009367:Neoplasm Staging; D053220:Receptors, TNF-Related Apoptosis-Inducing Ligand / Q000378:metabolism*
D053220:Receptors, TNF-Related Apoptosis-Inducing Ligand