[Neurochemical and behavioural alterations in animals due to a neurohomologous phospholipids and vitamin B6 association at CNS level].
The effect of a brain cortex phospholipids (BC-PL) and vit. B6 association on animal behaviour and enzymatic activities specific for CNS is studied. The motility and avoidance tests and cerebral L-amino acid aromatic decarboxylase activity were considered. The study was carried out in comparison with methedrine which effects are well known. On the basis of the results the conclusion is drawn that the effects obtained with BC-PL and vit. B6 association are very different from those obtained with methedrine; this suggests a different mecchanism of action at CNS level.
Aporti
F
F
Laboratori di Ricerca della FIDIA S.p.A., Abano Terme.
Toffano
G
G
Castellani
A
A
D000161:Acoustic Stimulation; D000818:Animals; D001142:Aromatic-L-Amino-Acid Decarboxylases / Q000032:analysis; D001362:Avoidance Learning / Q000187:drug effects*; D001522:Behavior, Animal / Q000187:drug effects* / Q000502:physiology; D001921:Brain / Q000201:enzymology; D001923:Brain Chemistry / Q000187:drug effects*; D003216:Conditioning, Operant / Q000187:drug effects; D004347:Drug Interactions; D008297:Male; D008694:Methamphetamine / Q000494:pharmacology; D051379:Mice; D008815:Mice, Inbred Strains; D009043:Motor Activity / Q000187:drug effects*; D018377:Neurotransmitter Agents / Q000096:biosynthesis; D010743:Phospholipids / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D013569:Synapses / Q000187:drug effects; D009435:Synaptic Transmission / Q000187:drug effects; D025101:Vitamin B 6 / Q000008:administration & dosage / Q000494:pharmacology*
D018377:Neurotransmitter Agents; D010743:Phospholipids; D008694:Methamphetamine; D025101:Vitamin B 6; D001142:Aromatic-L-Amino-Acid Decarboxylases