title: Leptin serum levels in the first year post-renal transplantation.
abstract: The aim of the present study was to evaluate the serum levels of leptin in the first year post-renal transplantation. Thirty-two patients and 19 healthy individuals were included. Serum leptin and biochemical markers were evaluated prospectively starting at transplant time (t(0)), and then every 3 months up to 1 year posttransplantation. The mean serum levels of leptin were higher in the pretransplant (t(0)) evaluation as compared with a control group of healthy volunteers (11.9 [9.2-25.2] and 7.7 [5.2-9.9] ng/mL, respectively; P < .0001). Leptinemia decreased significantly in the first 3 months after the renal transplantation (t(3)) (11.9 [9.2-25.2] to 7.1 [4.14-12.5] ng/mL; P < .0001) increased at t(6) to 10.6 (5.6-14.6) ng/mL and remained stable at t(9) (9.0 [5.2-18.3] ng/mL) and t(12) (9.3 [4.9-16.4] ng/mL). No correlation was found between leptin and renal function at any time during the study. In conclusion, during the first posttransplant year the serum leptin levels decreased significantly in relation to pretransplant period.
authors.affiliation: Post-Graduate Medical Sciences, Nephrology Program, Federal University of Rio Grande do Sul School of Medicine, Porto Alegre, Brazil.
authors.forename: G C
authors.initials: GC
authors.lastname: Souza
authors.forename: C A R
authors.initials: CA
authors.lastname: Costa
authors.forename: L F
authors.initials: LF
authors.lastname: Gonçalves
authors.forename: R C
authors.initials: RC
authors.lastname: Manfro
mesh_terms: D000328:Adult; D003920:Diabetes Mellitus / Q000097:blood; D005260:Female; D006801:Humans; D016030:Kidney Transplantation / Q000502:physiology*; D020738:Leptin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D018579:Patient Selection; D011446:Prospective Studies; D011863:Radioimmunoassay; D012016:Reference Values; D012086:Reoperation
chemical_list: D020738:Leptin