title: Intravenous immunoglobulin: an update on the clinical use and mechanisms of action.
abstract: Initially used as a replacement therapy for immunodeficiency diseases, intravenous immunoglobulin (IVIg) is now widely used for a number of autoimmune and inflammatory diseases. Considerable progress has been made in understanding the mechanisms by which IVIg exerts immunomodulatory effects in autoimmune and inflammatory disorders. The mechanisms of action of IVIg are complex, involving modulation of expression and function of Fc receptors, interference with activation of complement and the cytokine network and of idiotype network, regulation of cell growth, and effects on the activation, differentiation, and effector functions of dendritic cells, and T and B cells.
authors.affiliation: Department of Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India.
authors.forename: Vir-Singh
authors.initials: VS
authors.lastname: Negi
authors.forename: Sriramulu
authors.initials: S
authors.lastname: Elluru
authors.forename: Sophie
authors.initials: S
authors.lastname: Sibéril
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Graff-Dubois
authors.forename: Luc
authors.initials: L
authors.lastname: Mouthon
authors.forename: Michel D
authors.initials: MD
authors.lastname: Kazatchkine
authors.forename: Sébastien
authors.initials: S
authors.lastname: Lacroix-Desmazes
authors.forename: Jagadeesh
authors.initials: J
authors.lastname: Bayry
authors.forename: Srini V
authors.initials: SV
authors.lastname: Kaveri
mesh_terms: D001327:Autoimmune Diseases / Q000276:immunology / Q000473:pathology / Q000628:therapy; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000276:immunology* / Q000627:therapeutic use*; D007155:Immunologic Factors / Q000276:immunology / Q000627:therapeutic use; D007167:Immunotherapy; D012871:Skin Diseases / Q000276:immunology / Q000473:pathology / Q000628:therapy
chemical_list: D016756:Immunoglobulins, Intravenous; D007155:Immunologic Factors