title: Cytotoxic alkylpiperidine alkaloids from the Brazilian marine sponge Pachychalina alcaloidifera.
abstract: Four bis-piperidine alkaloids, madangamine F (1), haliclonacyclamine F (2). and arenosclerins D (3) and E (4), have been isolated from the marine sponge Pachychalina alcaloidifera and have been identified by analysis of spectroscopic data. The alkaloids displayed cytotoxic activity against different cancer cell lines. These results support the hypothesis of a common biogenetic origin for the Haplosclerida bis-piperidine and bis-pyridine alkaloids.
authors.affiliation: Instituto de Química de São Carlos, Universidade de São Paulo, CP 780, CEP 13560-970, São Carlos, SP, Brazil.
authors.forename: Jaine H H L
authors.initials: JH
authors.lastname: de Oliveira
authors.forename: Andréa M
authors.initials: AM
authors.lastname: Nascimento
authors.forename: Miriam H
authors.initials: MH
authors.lastname: Kossuga
authors.forename: Bruno C
authors.initials: BC
authors.lastname: Cavalcanti
authors.forename: Claudia O
authors.initials: CO
authors.lastname: Pessoa
authors.forename: Manoel O
authors.initials: MO
authors.lastname: Moraes
authors.forename: Mario L
authors.initials: ML
authors.lastname: Macedo
authors.forename: Antonio G
authors.initials: AG
authors.lastname: Ferreira
authors.forename: Eduardo
authors.initials: E
authors.lastname: Hajdu
authors.forename: Ulisses S
authors.initials: US
authors.lastname: Pinheiro
authors.forename: Roberto G S
authors.initials: RG
authors.lastname: Berlinck
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001938:Brazil; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006801:Humans; D008386:Marine Biology; D015394:Molecular Structure; D010880:Piperidines / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D011161:Porifera / Q000737:chemistry*
chemical_list: D000470:Alkaloids; D000970:Antineoplastic Agents; D010880:Piperidines