Acute life threatening event (ALTE) in an infant with human coronavirus HCoV-229E infection.
In this short report we discuss the temporal association between an acute life threatening event (ALTE) and a RT-PCR confirmed coronavirus HCoV-229E infection in a 4 months old otherwise healthy infant. More detailed microbiological investigations of affected children even without apparent signs of a respiratory tract infection may help to clarify the etiology in some patients and extend our understanding of the pathogenesis. PCR-based techniques should be utilized to increase the sensitivity of detection for old and new respiratory viral pathogens in comparable cases.
Simon
Arne
A
Children's Hospital Medical Centre, University of Bonn, Bonn, Germany. asimon@ukb.uni-bonn.de
Völz
Sebastian
S
Höfling
Katja
K
Kehl
Alexandra
A
Tillman
Ramona
R
Müller
Andreas
A
Kupfer
Bernd
B
Eis-Hübinger
Anna-Maria
AM
Lentze
Michael J
MJ
Bode
Udo
U
Schildgen
Oliver
O
D001049:Apnea / Q000209:etiology*; D001919:Bradycardia / Q000209:etiology*; D028941:Coronavirus 229E, Human / Q000235:genetics / Q000302:isolation & purification; D018352:Coronavirus Infections / Q000175:diagnosis*; D016638:Critical Illness; D004279:DNA, Viral / Q000302:isolation & purification; D005260:Female; D006801:Humans; D007223:Infant; D020133:Reverse Transcriptase Polymerase Chain Reaction
D004279:DNA, Viral