Unexpected long-term survival without evidence of disease after salvage chemotherapy for recurrent metastatic cervical cancer: a case series.
BACKGROUND
The prognosis of recurrent metastatic cervical cancer is extremely poor. Platinum-based palliative chemotherapy constitutes the mainstay of treatment. Cure is extremely rare.


METHODS
We present 3 cases of recurrent metastatic cervical cancer in which the patients remain disease-free many years after completing salvage chemotherapy and surgery. The patients remain with no evidence of disease at 6, 7, and 13 years, respectively, following recurrence.


CONCLUSIONS
In rare cases, an unexpected complete clinical remission and long-term survival without evidence of disease may be achieved in patients with recurrent metastatic cervical cancer treated with multimodal therapy.
Khoury-Collado
Fady
F
Department of Obstetrics and Gynecology, Lutheran Medical Center, Brooklyn, NY 11220, USA.
Bowes
Robert J
RJ
Jhamb
Namita
N
Aghajanian
Carol
C
Abu-Rustum
Nadeem R
NR
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy*; D002945:Cisplatin / Q000008:administration & dosage; D018572:Disease-Free Survival; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D007069:Ifosfamide / Q000008:administration & dosage; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy*; D017239:Paclitaxel / Q000008:administration & dosage; D016879:Salvage Therapy; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy*
D017239:Paclitaxel; D002945:Cisplatin; D005472:Fluorouracil; D007069:Ifosfamide