title: Investigations of the eye fundus using a simultaneous optical coherence tomography/indocyanine green fluorescence imaging system.
abstract: We develop a dual-channel optical coherence tomography/indocyanine green (OCT/ICG) fluorescence system based on our previously reported ophthalmic OCT/confocal imaging system. The confocal channel is tuned to the fluorescence wavelength range of the ICG dye and light from the same optical source is used to generate the OCT image and to excite the ICG fluorescence. The system enables the clinician to visualize simultaneously en face OCT slices and corresponding ICG angiograms of the ocular fundus, displayed side by side. C-scan (constant depth) and B-scan (cross section) images are collected by fast en face scanning (T-scan). The pixel-to-pixel correspondence between the OCT and angiography images enables the user to precisely capture OCT B-scans at selected points on the ICG confocal images.
authors.affiliation: University of Kent at Canterbury, Applied Optics Group, School of Physical Sciences, Canterbury CT2 7NH, United Kingdom. apiii@kent.ac.uk
authors.forename: Adrian G
authors.initials: AG
authors.lastname: Podoleanu
authors.forename: George M
authors.initials: GM
authors.lastname: Dobre
authors.forename: Ramona
authors.initials: R
authors.lastname: Cernat
authors.forename: John A
authors.initials: JA
authors.lastname: Rogers
authors.forename: Justin
authors.initials: J
authors.lastname: Pedro
authors.forename: Richard B
authors.initials: RB
authors.lastname: Rosen
authors.forename: Patricia
authors.initials: P
authors.lastname: Garcia
mesh_terms: D004867:Equipment Design; D019544:Equipment Failure Analysis; D005451:Fluorescein Angiography / Q000295:instrumentation* / Q000379:methods; D005654:Fundus Oculi; D006801:Humans; D007208:Indocyanine Green; D018613:Microscopy, Confocal / Q000295:instrumentation* / Q000379:methods; D008856:Microscopy, Fluorescence / Q000295:instrumentation* / Q000379:methods; D019047:Phantoms, Imaging; D015203:Reproducibility of Results; D012160:Retina / Q000166:cytology*; D042261:Retinoscopes; D012680:Sensitivity and Specificity; D018511:Systems Integration; D041623:Tomography, Optical Coherence / Q000295:instrumentation* / Q000379:methods
chemical_list: D007208:Indocyanine Green