title: Image correction scheme applied to functional diffuse optical tomography scattering images.
abstract: We have extended our investigation on the use of a linear algorithm for enhancing the accuracy of diffuse optical tomography (DOT) images, to include spatial maps of the diffusion coefficient. The results show that the corrected images are markedly improved in terms of estimated size, spatial resolution, two-object resolving power, and quantitative accuracy. These image-enhancing effects are significant at expected levels of diffusion-coefficient contrast in tissue and noise levels typical of experimental DOT data. Overall, the types and magnitudes of image-enhancing effects obtained here are qualitatively similar to those seen in previous studies on mu(a) perturbations. The implications for practical implementations of DOT time-series imaging are discussed.
authors.affiliation: Department of Pathology, State University of New York Downstate Medical Center, New York 11203, USA. harry.graber@downstate.edu
authors.forename: Harry L
authors.initials: HL
authors.lastname: Graber
authors.forename: Yong
authors.initials: Y
authors.lastname: Xu
authors.forename: Randall L
authors.initials: RL
authors.lastname: Barbour
mesh_terms: D000465:Algorithms; D016477:Artifacts; D003198:Computer Simulation; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008027:Light; D008954:Models, Biological; D012031:Refractometry / Q000379:methods*; D015203:Reproducibility of Results; D012542:Scattering, Radiation; D012680:Sensitivity and Specificity; D041622:Tomography, Optical / Q000379:methods*