[Molecular and chemical mechanism of Trichomonas vaginalis-induced contact-dependent cytotoxicity].
Trichomonas vaginalis parasitizes in human genitourinary tract. The protozoon adhering to target cell plays a critical role in its contact-dependent cytotoxicity. The enzymes synthesized by T.voginalis can hurt vaginalis epithelial cells (VECs) directly. The focal immune reaction in the location parasitized by the parasite may provide an immunologic protection. Meanwhile, inflammatory factors and immune cells may aggravate the situation. In general, the T. vaginalis-induced contact-dependent cytotoxicity is a result of the involvement of some molecular and chemical factors.
Yang
Shu-guo
SG
Department of Parasitology, School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, China.
Tie
Chao-nan
CN
Wang
Ya-jing
YJ
D000818:Animals; D017209:Apoptosis; D051017:Apoptosis Regulatory Proteins / Q000378:metabolism; D015815:Cell Adhesion Molecules / Q000378:metabolism; D002470:Cell Survival; D003546:Cysteine Endopeptidases / Q000378:metabolism; D005260:Female; D006801:Humans; D015800:Protozoan Proteins / Q000378:metabolism; D014247:Trichomonas Vaginitis / Q000378:metabolism / Q000469:parasitology / Q000473:pathology*; D014246:Trichomonas vaginalis / Q000254:growth & development* / Q000378:metabolism
C096723:AP65-1 protein, Trichomonas vaginalis; D051017:Apoptosis Regulatory Proteins; D015815:Cell Adhesion Molecules; D015800:Protozoan Proteins; D003546:Cysteine Endopeptidases