Establishing the triplet nature of the genetic code.
In 1961, Crick, Barnett, Brenner, and Watts-Tobin (Crick et al., 1961) designed an elegant experimental strategy to determine the nature of the genetic code. Remarkably, they reached the correct conclusion despite the absence of technology to analyze and compare DNA and protein sequences.
Yanofsky
Charles
C
Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA.
D000595:Amino Acid Sequence; D017122:Bacteriophage T4 / Q000235:genetics; D001483:Base Sequence; D004247:DNA / Q000737:chemistry / Q000266:history; D005815:Genetic Code; D005821:Genetic Techniques / Q000266:history; D049673:History, 20th Century; D008967:Molecular Biology / Q000266:history*; D009154:Mutation; D011506:Proteins / Q000737:chemistry; D012107:Research Design
D011506:Proteins; D004247:DNA