Renal and liver transplantation for toxin-induced organ failure.
OBJECTIVE
Determine the number and outcome of renal (January 1987-June 2001, inclusive) and liver transplants (January 1993-June 2001) performed in Ireland for drug or toxin-induced organ failure and identify the toxins involved.


METHODS
Retrospective review of national transplant coordinators' records and patient charts.


RESULTS
Fourteen patients received renal transplants for nephropathy secondary to drugs or toxins. In 12 of these cases, renal failure was attributed to chronic toxicity, principally cyclosporin A therapy (seven cases). One-year patient and graft survival were 100%. Twenty-nine liver transplants were for toxin-induced organ failure, and 20 of these were for chronic ethanol induced liver disease. One-year patient and graft survival rates were 77% and 73%, respectively.


CONCLUSIONS
Kidney and liver transplants were needed more often because of chronic toxicity than acute poisoning. Both groups had good outcomes at one year post-transplantation.
Casey
P B
PB
National Poisons Information Centre Beaumont Hospital, Dublin, Ireland. patriciacasey@beaumont.ie
Tracey
J A
JA
Cunningham
P
P
Counihan
A
A
Fleming
J
J
Hickey
D
D
Hegarty
J
J
D006801:Humans; D007494:Ireland / Q000453:epidemiology; D016030:Kidney Transplantation; D017114:Liver Failure, Acute / Q000139:chemically induced / Q000601:surgery*; D016031:Liver Transplantation; D011041:Poisoning / Q000601:surgery*; D051437:Renal Insufficiency / Q000139:chemically induced / Q000601:surgery*; D012189:Retrospective Studies; D014118:Toxins, Biological / Q000506:poisoning*; D015262:Xenobiotics / Q000506:poisoning*
D014118:Toxins, Biological; D015262:Xenobiotics