Platelet-leukocyte interactions in inflammation and atherothrombosis.
Inflammatory processes at the vascular wall result in the development of atherosclerosis. Platelet interactions with leukocytes may play a key role in the initiation of inflammation. They trigger autocrine and paracrine activation processes, leading to leukocyte recruitment (in)to the vascular wall. This article highlights the molecular basis and the inflammatory pathways initiated by platelet-leukocyte interactions.
May
Andreas E
AE
Medizinische Klinik III, Eberhard Karls Universität Tübingen, Tübingen, Germany. andreas.may@med.uni-tuebingen.de
Langer
Harald
H
Seizer
Peter
P
Bigalke
Boris
B
Lindemann
Stephan
S
Gawaz
Meinrad
M
D001157:Arterial Occlusive Diseases / Q000209:etiology; D001792:Blood Platelets / Q000473:pathology / Q000502:physiology; D002450:Cell Communication / Q000502:physiology*; D002634:Chemotaxis, Leukocyte; D004730:Endothelium, Vascular / Q000473:pathology; D006801:Humans; D007249:Inflammation / Q000209:etiology*; D007962:Leukocytes / Q000473:pathology / Q000502:physiology; D013927:Thrombosis / Q000209:etiology*