title: HIV-1 subtype D infection is associated with faster disease progression than subtype A in spite of similar plasma HIV-1 loads.
abstract: We investigated the effect of human immunodeficiency virus type 1 (HIV-1) subtype on disease progression among 145 Kenyan women followed from the time of HIV-1 acquisition. Compared with those infected with subtype A, women infected with subtype D had higher mortality (hazard ratio, 2.3 [95% confidence interval, 1.0-5.6]) and a faster rate of CD4 cell count decline (P=.003). The mortality risk persisted after adjustment for plasma HIV-1 load. There were no differences in plasma viral load by HIV-1 subtype during follow-up. HIV-1 subtype D infection is associated with a >2-fold higher risk of death than subtype A infection, in spite of similar plasma HIV-1 loads.
authors.affiliation: Department of Medicine, University of Washington, Seattle, WA, USA.
authors.forename: Jared M
authors.initials: JM
authors.lastname: Baeten
authors.forename: Bhavna
authors.initials: B
authors.lastname: Chohan
authors.forename: Ludo
authors.initials: L
authors.lastname: Lavreys
authors.forename: Vrasha
authors.initials: V
authors.lastname: Chohan
authors.forename: R Scott
authors.initials: RS
authors.lastname: McClelland
authors.forename: Laura
authors.initials: L
authors.lastname: Certain
authors.forename: Kishorchandra
authors.initials: K
authors.lastname: Mandaliya
authors.forename: Walter
authors.initials: W
authors.lastname: Jaoko
authors.forename: Julie
authors.initials: J
authors.lastname: Overbaugh
mesh_terms: D000328:Adult; D018791:CD4 Lymphocyte Count; D004279:DNA, Viral / Q000097:blood; D018450:Disease Progression; D005260:Female; D015483:HIV Antibodies / Q000097:blood; D015658:HIV Infections / Q000401:mortality* / Q000503:physiopathology / Q000821:virology*; D015497:HIV-1 / Q000145:classification* / Q000235:genetics / Q000276:immunology / Q000472:pathogenicity*; D006801:Humans; D053208:Kaplan-Meier Estimate; D007630:Kenya; D012307:Risk Factors; D013997:Time Factors; D019562:Viral Load
chemical_list: D004279:DNA, Viral; D015483:HIV Antibodies