[Treatment of brain ischemic stroke by co-transplantation of neural stem cells and endothelial progenitor cells].
OBJECTIVE
To discuss the feasibility of treating the brain ischemic stroke by the co-transplantation of the neural stem cells(NSCs) and the endothelial progenitor cells(EPCs).


METHODS
The original biomedical articles concerned with the treatment of the brain ischemic therapy by the use of the NSCs and the EPCs were extensively reviewed as well as retrieved and analyzed.


RESULTS
The review revealed that the NSCs and the EPCs could migrate to the injured area due to brain ischemic stroke, the environment of the local microcirculation could induce the neurogenesis and the vasculogenesis to repair the injury, and the neurogenesis and vasculogenesis could promote each other.


CONCLUSIONS
The co-transplantation of the NSCs and the EPCs can represent a new promising strategy for more effectively solving the two difficult problems of the neural cell loss and the vascular obstruction caused by the brain ischemic stroke.
Liu
Jianmin
J
Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu Sichuan, 610041, P. R. China. solarjm@sina.com
Mao
Boyong
B
D000818:Animals; D002545:Brain Ischemia / Q000473:pathology / Q000628:therapy*; D018929:Cell Culture Techniques / Q000379:methods; D002454:Cell Differentiation; D002478:Cells, Cultured; D004730:Endothelium, Vascular / Q000166:cytology*; D006801:Humans; D051379:Mice; D055495:Neurogenesis; D009474:Neurons / Q000166:cytology*; D051381:Rats; D033581:Stem Cell Transplantation / Q000379:methods*; D020521:Stroke / Q000473:pathology / Q000628:therapy*