Prospective screening for human leukocyte antigen-B*5701 avoids abacavir hypersensitivity reaction in the ethnically mixed French HIV population.
The association of human leukocyte antigen-B*5701 with abacavir hypersensitivity varies depending on ethnic origin. We confirmed the high specificity of B*5701 in the ethnically mixed French population and used a rapid and inexpensive polymerase chain reaction strategy to evaluate the predictiveness of B*5701 screening. The incidence of hypersensitivity decreased from 12% before screening to 0% after screening, and the rate of unwarranted interruptions of abacavir therapy decreased from 10.2% to 0.73%. We therefore recommend the implementation of this cost-effective screen before treatment with abacavir.
Zucman
David
D
Réseau Ville-Hopital Val de Seine, Hopital Foch, Suresnes, France.
Truchis
Pierre de
Pd
Majerholc
Catherine
C
Stegman
Sophia
S
Caillat-Zucman
Sophie
S
D019380:Anti-HIV Agents / Q000009:adverse effects* / Q000627:therapeutic use; D044383:Black People / Q000706:statistics & numerical data; D015224:Dideoxynucleosides / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D005602:France / Q000453:epidemiology / Q000208:ethnology; D005820:Genetic Testing; D006678:HIV; D015658:HIV Infections / Q000188:drug therapy / Q000276:immunology; D015235:HLA-B Antigens / Q000235:genetics*; D006801:Humans; D006967:Hypersensitivity / Q000235:genetics / Q000517:prevention & control*; D015994:Incidence; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction / Q000191:economics / Q000379:methods; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D013383:Suburban Population; D014505:Urban Population; D044465:White People / Q000706:statistics & numerical data; D000099227:Abacavir
D019380:Anti-HIV Agents; D015224:Dideoxynucleosides; D015235:HLA-B Antigens; D000099227:Abacavir; C484830:HLA-B*57:01 antigen