A case of naturally acquired inhalation anthrax: clinical care and analyses of anti-protective antigen immunoglobulin G and lethal factor.
This report describes the first case of naturally acquired inhalation anthrax in the United States since 1976. The patient's clinical course included adjunctive treatment with human anthrax immunoglobulin. Clinical correlation of serologic assays for the lethal factor component of lethal toxin and anti-protective antigen immunoglobulin G are also presented.
Walsh
James J
JJ
Section of Pulmonary and Critical Care Medicine, Guthrie Clinic, Sayre, PA, USA.
Pesik
Nicki
N
Quinn
Conrad P
CP
Urdaneta
Veronica
V
Dykewicz
Clare A
CA
Boyer
Anne E
AE
Guarner
Jeannette
J
Wilkins
Patricia
P
Norville
Kim J
KJ
Barr
John R
JR
Zaki
Sherif R
SR
Patel
Jean B
JB
Reagan
Sarah P
SP
Pirkle
James L
JL
Treadwell
Tracee A
TA
Messonnier
Nancy Rosenstein
NR
Rotz
Lisa D
LD
Meyer
Richard F
RF
Stephens
David S
DS
D000328:Adult; D000881:Anthrax / Q000175:diagnosis* / Q000628:therapy*; D022122:Anthrax Vaccines / Q000008:administration & dosage* / Q000276:immunology; D000942:Antigens, Bacterial / Q000276:immunology*; D001408:Bacillus anthracis / Q000302:isolation & purification; D001774:Blood Chemical Analysis; D004781:Environmental Exposure / Q000009:adverse effects; D004797:Enzyme-Linked Immunosorbent Assay; D005098:Exotoxins / Q000097:blood; D005500:Follow-Up Studies; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology* / Q000378:metabolism; D001239:Inhalation; D008297:Male; D018570:Risk Assessment; D012720:Severity of Illness Index; D014195:Travel; D014481:United States
D022122:Anthrax Vaccines; D000942:Antigens, Bacterial; D005098:Exotoxins; D007074:Immunoglobulin G