Long lived microbubbles for oxygen delivery.
Exceptionally long lived microbubbles containing a fluorocarbon as part of their filling gas have been obtained by using a fluorinated phospholipid instead of a standard phospholipid as shell component. An unexpected, strong synergistic effect between the fluorocarbon gas and the fluorinated phospholipid has been discovered. Such bubbles could be used for in vivo oxygen delivery, ultrasound contrast imaging and drug delivery.
Gerber
Frédéric
F
Systèmes Organisés Fluorés à Finalités Thérapeutiques (SOFFT), Institut Charles Sadron, Strasbourg Cedex, France.
Waton
Gilles
G
Krafft
Marie Pierre
MP
Vandamme
Thierry F
TF
D001802:Blood Substitutes / Q000737:chemistry; D003287:Contrast Media / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry; D005466:Fluorocarbons / Q000627:therapeutic use*; D006207:Half-Life; D045423:Microbubbles; D010100:Oxygen / Q000378:metabolism*; D010743:Phospholipids / Q000737:chemistry / Q000627:therapeutic use
D001802:Blood Substitutes; D003287:Contrast Media; D004337:Drug Carriers; D005466:Fluorocarbons; D010743:Phospholipids; D010100:Oxygen