Anti-metastatic activity of heparin is probably associated with modulation of SDF-1-CXCR4 axis.
Simka
Marian
M
D000970:Antineoplastic Agents / Q000494:pharmacology; D001792:Blood Platelets / Q000378:metabolism; D002468:Cell Physiological Phenomena; D054377:Chemokine CXCL12; D019743:Chemokines, CXC / Q000378:metabolism*; D002986:Clinical Trials as Topic; D015972:Gene Expression Regulation, Neoplastic; D006493:Heparin / Q000378:metabolism / Q000627:therapeutic use*; D006801:Humans; D007962:Leukocytes / Q000378:metabolism; D008954:Models, Biological; D009362:Neoplasm Metastasis; D019718:Receptors, CXCR4 / Q000378:metabolism*
D000970:Antineoplastic Agents; C515255:CXCL12 protein, human; D054377:Chemokine CXCL12; D019743:Chemokines, CXC; D019718:Receptors, CXCR4; D006493:Heparin