title: Photonic explorers based on multifunctional nanoplatforms for biosensing and photodynamic therapy.
abstract: Nanoparticle-based photonic explorers have been developed for intracellular sensing and photodynamic therapy (PDT). The design employs nanoparticles made of various matrices as multifunctional nanoplatforms, loading active components by encapsulation or covalent attachment. The nanoplatform for biosensing has been successfully applied to intracellular measurements of important ionic and molecular species. The nanoplatform for PDT has shown high therapeutic efficacy in a rat 9L gliosarcoma model. Specifically, a multifunctional nanoplatform that encompasses magnetic resonance imaging (MRI) and PDT agents inside, as well as targeting ligands on the surface, has been developed and applied in vivo, resulting in much improved MRI contrast enhancement and PDT efficacy.
authors.affiliation: University of Michigan, Michigan 48109, USA. yeleekoo@umich.edu
authors.forename: Yong-Eun Lee
authors.initials: YE
authors.lastname: Koo
authors.forename: Wenzhe
authors.initials: W
authors.lastname: Fan
authors.forename: Hoejin
authors.initials: H
authors.lastname: Hah
authors.forename: Hao
authors.initials: H
authors.lastname: Xu
authors.forename: Dan
authors.initials: D
authors.lastname: Orringer
authors.forename: Brian
authors.initials: B
authors.lastname: Ross
authors.forename: Alnawaz
authors.initials: A
authors.lastname: Rehemtulla
authors.forename: Martin A
authors.initials: MA
authors.lastname: Philbert
authors.forename: Raoul
authors.initials: R
authors.lastname: Kopelman
mesh_terms: D015374:Biosensing Techniques / Q000295:instrumentation / Q000379:methods*; D016503:Drug Delivery Systems / Q000295:instrumentation / Q000379:methods*; D049329:Nanostructures / Q000627:therapeutic use*; D010778:Photochemotherapy / Q000295:instrumentation / Q000379:methods*; D017785:Photons / Q000627:therapeutic use*