title: How cost-effective is screening for abdominal aortic aneurysms?
abstract: OBJECTIVE
  To provide reliable estimates of the long-term cost-effectiveness of abdominal aortic aneurysm screening in men.
  
  
  METHODS
  A Markov health economic decision model for screening is described and extrapolated to 30 years. The strategy modelled involves a one-off scan at age 65 years, with annual and three-monthly follow-up scans for small and medium aneurysms, respectively. Referral for elective surgery occurs at an aortic diameter of 5.5 cm. Model parameters are estimated from patient-level data from the UK Multi-centre Aneurysm Screening Study. Model structure is validated on this trial's data, and input parameter uncertainty is addressed by probabilistic sensitivity analysis. Costs and life-years gained are obtained for both screening and no systematic screening strategies.
  
  
  RESULTS
  Cost-effectiveness improves dramatically when considered over longer timescales. Taking a 30-year perspective, screening for abdominal aortic aneurysms in men is highly cost-effective at 2320 pounds per life-year gained (95% uncertainty interval: 1600 pounds to 4240 pounds). Adjusting life-years for the age-specific health-related quality of life experienced in this population gave a figure of 2970 pounds (95% uncertainty interval: 2030 pounds to 5430 pounds) per quality-adjusted life-year gained. The additional cost of screening the UK male population is estimated to be 19 m pounds per year.
  
  
  CONCLUSIONS
  The long-term cost-effectiveness of screening for abdominal aortic aneurysms in men is highly attractive and this evidence provides further support for a national screening programme in the UK.
authors.affiliation: MRC Biostatistics Unit, Institute of Public Health, Robinson Way, Cambridge CB2 2SR, UK. lois.kim@mrc-bsu.cam.ac.uk
authors.forename: L G
authors.initials: LG
authors.lastname: Kim
authors.forename: S G
authors.initials: SG
authors.lastname: Thompson
authors.forename: A H
authors.initials: AH
authors.lastname: Briggs
authors.forename: M J
authors.initials: MJ
authors.lastname: Buxton
authors.forename: H E
authors.initials: HE
authors.lastname: Campbell
mesh_terms: D000368:Aged; D017544:Aortic Aneurysm, Abdominal / Q000175:diagnosis*; D003362:Cost-Benefit Analysis; D003661:Decision Support Techniques; D006801:Humans; D008297:Male; D008390:Markov Chains; D008403:Mass Screening / Q000191:economics*; D006113:United Kingdom