title: Increased body temperature after reperfused acute myocardial infarction is associated with adverse left ventricular remodeling.
abstract: BACKGROUND
  Fever is frequently observed in patients with acute myocardial infarction (AMI); however, its prognostic significance remains to be determined. We sought to determine the prognostic significance of increased body temperature (BT) after AMI.
  
  
  RESULTS
  We examined 156 consecutive patients with reperfused first anterior AMI. Axillary BT was serially measured every 6 hours for a week. Patients were divided into quartiles by peak BT from the lowest to highest levels. Peak BT within the first week showed a significant positive correlation with peak C-reactive protein level (P < .0001), but not with peak creatine kinase level. There were positive correlations of peak BT with the incidence of pump failure (P = .022), left ventricular (LV) aneurysm (P = .029), and readmission for heart failure (P = .006). Higher peak BT was associated with greater LV end-diastolic volume (P = .031), greater end-systolic volume (P = .008), and lower LV ejection fraction (P = .014) 2 weeks after AMI. Multiple logistic regression analyses revealed that peak BT quartile was an independent predictor of in-hospital cardiac events (odds ratio = 1.61/quartile, P = .008). Furthermore, peak BT quartile was a significant predictor of readmission for heart failure by Cox proportional hazard model analysis (P = .048).
  
  
  CONCLUSIONS
  Increased BT after AMI was associated with a worse clinical outcome and infarct expansion, suggesting a relationship between systemic inflammatory response and LV remodeling.
authors.affiliation: Division of Cardiology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
authors.forename: Kotaro
authors.initials: K
authors.lastname: Naito
authors.forename: Toshihisa
authors.initials: T
authors.lastname: Anzai
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Yoshikawa
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Maekawa
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Sugano
authors.forename: Takashi
authors.initials: T
authors.lastname: Kohno
authors.forename: Keitaro
authors.initials: K
authors.lastname: Mahara
authors.forename: Teruo
authors.initials: T
authors.lastname: Okabe
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Asakura
authors.forename: Satoshi
authors.initials: S
authors.lastname: Ogawa
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015906:Angioplasty, Balloon, Coronary; D001831:Body Temperature; D005260:Female; D005334:Fever / Q000209:etiology / Q000503:physiopathology*; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000150:complications / Q000503:physiopathology* / Q000628:therapy*; D015425:Myocardial Reperfusion; D018377:Neurotransmitter Agents / Q000097:blood; D011379:Prognosis; D015912:Thrombolytic Therapy; D020257:Ventricular Remodeling / Q000502:physiology*
chemical_list: D015850:Interleukin-6; D018377:Neurotransmitter Agents