title: Prognostic values of alpha2-macroglobulin, fibrinogen and albumin in regards to mortality and frailty in old rats.
abstract: The study aimed to determine if acute phase proteins (APP) are markers of frailty in old rats. We evaluated in male Wistar rats at 96 weeks of age (n=72) whether single measurements of alpha(2)-macroglobulin, fibrinogen and albumin are predictive of mortality, body weight loss and inflammatory status during a 10-week follow-up period. Rats were clustered depending on levels of these APP at baseline. Rats with extremely high levels of alpha(2)-macroglobulin or fibrinogen (upper quartiles), or extremely low level of albumin (lower quartile), had an 11.6, 8.1 and 5.3-fold higher risk of mortality, respectively, than other rats. Body weight loss was negatively correlated with alpha(2)-macroglobulin, a trend was observed with fibrinogen (P=0.08) but not with albumin. Rats with fibrinogen levels >4.0 g/L or alpha(2)-macroglobulin levels >91 mg/L (respective top halves) at 96 weeks of age had higher levels of alpha(2)-macroglobulin and fibrinogen and lower levels of albumin throughout the follow-up period and higher levels of sTNFR-1 and lipopolysaccharide-binding protein at 106 weeks of age. Highest levels of alpha(2)-macroglobulin, fibrinogen and lowest albumin were predictive of mortality, whereas moderate levels of alpha(2)-macroglobulin and fibrinogen were, according to body weight loss and inflammatory status, markers of frailty in old rats.
authors.affiliation: INRA, Centre Clermont-Ferrand Theix, UMR 1019 Unité de Nutrition Humaine, F-63122 Saint-Genès-Champanelle, France.
authors.forename: Gilles
authors.initials: G
authors.lastname: Mayot
authors.forename: Karine
authors.initials: K
authors.lastname: Vidal
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Martin
authors.forename: Denis
authors.initials: D
authors.lastname: Breuillé
authors.forename: Stephanie
authors.initials: S
authors.lastname: Blum
authors.forename: Christiane
authors.initials: C
authors.lastname: Obled
authors.forename: Isabelle
authors.initials: I
authors.lastname: Papet
mesh_terms: D000209:Acute-Phase Proteins / Q000378:metabolism; D000375:Aging / Q000097:blood* / Q000473:pathology; D000818:Animals; D002352:Carrier Proteins / Q000097:blood; D005340:Fibrinogen / Q000378:metabolism*; D007249:Inflammation / Q000097:blood; D018836:Inflammation Mediators / Q000097:blood; D008136:Longevity / Q000502:physiology; D008297:Male; D008562:Membrane Glycoproteins / Q000097:blood; D011379:Prognosis; D051381:Rats; D017208:Rats, Wistar; D047888:Receptors, Tumor Necrosis Factor, Type I / Q000097:blood; D012709:Serum Albumin / Q000378:metabolism*; D015431:Weight Loss / Q000502:physiology; D000511:alpha-Macroglobulins / Q000378:metabolism*; D000099231:Lipopolysaccharide-Binding Protein
chemical_list: D000209:Acute-Phase Proteins; D002352:Carrier Proteins; D005340:Fibrinogen; D018836:Inflammation Mediators; D008562:Membrane Glycoproteins; D047888:Receptors, Tumor Necrosis Factor, Type I; D012709:Serum Albumin; D000511:alpha-Macroglobulins; D000099231:Lipopolysaccharide-Binding Protein; C506237:Tnfrsf1a protein, rat