title: Design and validation of an image-guided robot for small animal research.
abstract: We developed an image-guided robot system to achieve highly accurate placement of thin needles and probes into in-vivo rodent tumor tissue in a predefined pattern that is specified on a preoperative image. This system can be used for many experimental procedures where the goal is to correlate a set of physical measurements with a corresponding set of image intensities or, more generally, to perform a physical action at a set of anatomic points identified on a preoperative image. This paper focuses on the design and validation of the robot system, where the first application is to insert oxygen measurement probes in a three-dimensional (3D) grid pattern defined with respect to a PET scan of a tumor. The design is compatible with CT and MRI, which we plan to use to identify targets for biopsy and for the injection of adenoviral sequences for gene therapy. The validation is performed using a phantom and includes a new method for estimating the Fiducial Localization Error (FLE) based on the measured Fiducial Distance Error (FDE).
authors.affiliation: Department of Computer Science, Johns Hopkins University, USA. pkaz@jhu.edu
authors.forename: Peter
authors.initials: P
authors.lastname: Kazanzides
authors.forename: Jenghwa
authors.initials: J
authors.lastname: Chang
authors.forename: Iulian
authors.initials: I
authors.lastname: Iordachita
authors.forename: Jack
authors.initials: J
authors.lastname: Li
authors.forename: C Clifton
authors.initials: CC
authors.lastname: Ling
authors.forename: Gabor
authors.initials: G
authors.lastname: Fichtinger
mesh_terms: D000818:Animals; D001707:Biopsy, Needle / Q000295:instrumentation* / Q000379:methods; D004867:Equipment Design; D019544:Equipment Failure Analysis; D007267:Injections / Q000295:instrumentation* / Q000379:methods; D019047:Phantoms, Imaging; D049268:Positron-Emission Tomography / Q000295:instrumentation* / Q000379:methods / Q000662:veterinary*; D012106:Research / Q000295:instrumentation*; D012107:Research Design; D012371:Robotics / Q000295:instrumentation* / Q000379:methods; D025321:Surgery, Computer-Assisted / Q000295:instrumentation* / Q000379:methods