Treatment of vulvovaginal erosive and stenosing lichen planus by surgical dilatation and methotrexate.
We treated five patients with stenosing lichen planus [LP] of the vulvovaginal region with methotrexate supplemented with ultrapotent corticosteroid cream and tacrolimus, in combination with surgical dilatation. All patients experienced long-term symptom relief, and there was only minimal or moderate re-stenosing of the vagina on follow-up for 2-41 months.
Kortekangas-Savolainen
Outi
O
Department of Dermatology, Turku University Hospital, Finland. outi.kortekangas-savolainen@tyks.fi
Kiilholma
Pentti
P
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000368:Aged; D003131:Combined Modality Therapy; D003879:Dermatologic Agents / Q000627:therapeutic use*; D004106:Dilatation; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008727:Methotrexate / Q000627:therapeutic use*; D008875:Middle Aged; D009824:Ointments; D012008:Recurrence; D016559:Tacrolimus / Q000627:therapeutic use; D007724:Vulvar Lichen Sclerosus / Q000628:therapy*
D000305:Adrenal Cortex Hormones; D003879:Dermatologic Agents; D007166:Immunosuppressive Agents; D009824:Ointments; D016559:Tacrolimus; D008727:Methotrexate