Boronated DNA-binding compounds as potential agents for boron neutron capture therapy.
Boron Neutron Capture Therapy (BNCT) is a binary cancer treatment that exploits the short range particles released from a nuclear fission reaction involving the non-radioactive 10B nucleus and low-energy (thermal) neutrons for the destruction of tumour cells. If boronated agents are targeted towards chromosomal DNA, the efficiency of BNCT is greatly enhanced. This article presents a concise review of DNA-binding compounds that have been functionalised with boron.
Crossley
Ellen L
EL
School of Chemistry, The University of Sydney, Sydney, NSW 2006, Australia.
Ziolkowski
Erin J
EJ
Coderre
Jeffrey A
JA
Rendina
Louis M
LM
D000477:Alkylating Agents / Q000737:chemistry / Q000627:therapeutic use; D000818:Animals; D001896:Boron Compounds / Q000737:chemistry* / Q000627:therapeutic use; D016754:Boron Neutron Capture Therapy; D004247:DNA / Q000737:chemistry*; D006801:Humans; D007364:Intercalating Agents / Q000737:chemistry / Q000627:therapeutic use; D015394:Molecular Structure; D009369:Neoplasms / Q000532:radiotherapy*; D009705:Nucleosides / Q000737:chemistry
D000477:Alkylating Agents; D001896:Boron Compounds; D007364:Intercalating Agents; D009705:Nucleosides; D004247:DNA