Nonphosphate inhibitors of IspE protein, a kinase in the non-mevalonate pathway for isoprenoid biosynthesis and a potential target for antimalarial therapy.
Hirsch
Anna K H
AK
Laboratorium für Organische Chemie, ETH Zürich, Hönggerberg, HCI, 8093 Zürich, Switzerland.
Lauw
Susan
S
Gersbach
Philipp
P
Schweizer
W Bernd
WB
Rohdich
Felix
F
Eisenreich
Wolfgang
W
Bacher
Adelbert
A
Diederich
François
F
D000962:Antimalarials / Q000138:chemical synthesis* / Q000627:therapeutic use; D001667:Binding, Competitive; D016503:Drug Delivery Systems; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000627:therapeutic use; D029968:Escherichia coli Proteins / Q000037:antagonists & inhibitors* / Q000737:chemistry; D043564:Inorganic Pyrophosphatase / Q000037:antagonists & inhibitors / Q000737:chemistry; D008798:Mevalonic Acid / Q000737:chemistry* / Q000378:metabolism; D010710:Phosphates / Q000737:chemistry; D017853:Phosphotransferases (Alcohol Group Acceptor) / Q000037:antagonists & inhibitors* / Q000737:chemistry; D013729:Terpenes / Q000737:chemistry* / Q000378:metabolism; D016963:Thermus thermophilus / Q000201:enzymology; D014166:Transferases / Q000037:antagonists & inhibitors / Q000737:chemistry
D000962:Antimalarials; D004791:Enzyme Inhibitors; D029968:Escherichia coli Proteins; D010710:Phosphates; D013729:Terpenes; D014166:Transferases; C109461:deoxyxylulose-5-phosphate synthase; D017853:Phosphotransferases (Alcohol Group Acceptor); C404502:IspE protein, E coli; D043564:Inorganic Pyrophosphatase; D008798:Mevalonic Acid