[Molecular mechanisms of cytoprotective action of the plant proanthocyanidins in gastric lesions].
The molecular defence mechanisms against ethanol- and stress-induced (WRS) gastric lesions under the action of plant proanthocyanidins from grapefruit-seed extract (GSE) were investigated. Pre-treatment with GSE (8-64 mg/kg/day) in dose-dependent manner attenuated gastric lesions induced by 100% ethanol and WRS; the doses of GCE reducing these lesions by 50% (ID50) were 28 and 36 mg/kg/day, respectively and this protective effect was similar to that obtained with PGE2 analogue. Lesions reduction was also accompanied by improvement of gastric blood flow, antiradical action, increased mucosal generation of PGE2, antioxidant activity.
Zaiachkivs'ka
O S
OS
D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D032083:Citrus paradisi / Q000737:chemistry*; D019610:Cytoprotection / Q000187:drug effects*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D005753:Gastric Mucosa / Q000187:drug effects / Q000201:enzymology / Q000473:pathology; D005756:Gastritis / Q000201:enzymology / Q000473:pathology / Q000517:prevention & control*; D008297:Male; D010936:Plant Extracts / Q000302:isolation & purification / Q000627:therapeutic use; D044945:Proanthocyanidins / Q000302:isolation & purification / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D012639:Seeds / Q000737:chemistry
D000975:Antioxidants; D010936:Plant Extracts; D044945:Proanthocyanidins