title: Feasibility of contrast-enhanced sonography during resection of cerebral tumours: initial results of a prospective study.
abstract: The aim of this study was to adapt the ultrasonographical techniques developed for brain perfusion imaging to an intraoperative setting for topographic diagnosis of cerebral tumours. During surgery, the patients underwent contrast-enhanced ultrasonography (phase inversion harmonic imaging, bolus kinetic, fitted model function). Endocavity curved array (6.5EC10, 6.5 MHz) was used intraoperatively. The ultrasound contrast agent SonoVue (Bracco) was administered IV as a bolus injection. Off-line, time-intensity curves as well as perfusion maps were calculated and parameters such as peak intensity were locally extracted to characterise perfusion. Seven patients with brain tumours of different histologic types were subjected to contrast-enhanced ultrasonography during surgery. Tissue differentiation with contrast agent was superior to conventional B-mode ultrasound imaging. Intraoperative contrast-enhanced ultrasonography enabled visualisation of cerebral tumours in high spatial resolution.
authors.affiliation: Department of Neurosurgery, Ruhr-University Bochum, Knappschaftskrankenhaus Bochum, Bochum, Germany. martin.engelhardt@ruhr-uni-bochum.de
authors.forename: Martin
authors.initials: M
authors.lastname: Engelhardt
authors.forename: Christian
authors.initials: C
authors.lastname: Hansen
authors.forename: Jens
authors.initials: J
authors.lastname: Eyding
authors.forename: Wilko
authors.initials: W
authors.lastname: Wilkening
authors.forename: Christopher
authors.initials: C
authors.lastname: Brenke
authors.forename: Christos
authors.initials: C
authors.lastname: Krogias
authors.forename: Martin
authors.initials: M
authors.lastname: Scholz
authors.forename: Albrecht
authors.initials: A
authors.lastname: Harders
authors.forename: Helmut
authors.initials: H
authors.lastname: Ermert
authors.forename: Kirsten
authors.initials: K
authors.lastname: Schmieder
mesh_terms: D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000000981:diagnostic imaging* / Q000601:surgery*; D003287:Contrast Media / Q000008:administration & dosage*; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D007432:Intraoperative Period; D008297:Male; D008875:Middle Aged; D010743:Phospholipids / Q000008:administration & dosage*; D011446:Prospective Studies; D013459:Sulfur Hexafluoride / Q000008:administration & dosage*; D018084:Ultrasonography, Interventional / Q000379:methods*
chemical_list: D003287:Contrast Media; D010743:Phospholipids; C420843:contrast agent BR1; D013459:Sulfur Hexafluoride