The orphan nuclear receptor Rev-erbalpha: a transcriptional link between circadian rhythmicity and cardiometabolic disease.
OBJECTIVE
This review focuses on recent advances on the role of the orphan nuclear receptor Rev-erbalpha, a transcription factor participating in the control of circadian rhythm and cardiometabolic disease.


RESULTS
Circadian patterns of cardiovascular vulnerability are well documented, with a peak incidence of cardiovascular events in the morning. Recent studies have outlined the importance of the Clock genes in the development of metabolic disorders predisposing to atherosclerosis. Rev-erbalpha is a nuclear receptor that regulates hepatic and adipose lipid metabolism as well as vascular inflammation. Moreover, Rev-erbalpha is also part of the clock transcription machinery and the target of some clock transcription factors.


CONCLUSIONS
These findings identify Rev-erbalpha as a modulator of cardiovascular risk factors and as a determinant of the circadian regulation of metabolic pathways. Moreover, Rev-erbalpha crosstalks with other nuclear receptors which influence atherosclerosis susceptibility. Rev-erbalpha may thus serve to integrate metabolic and circadian signals.
Fontaine
Coralie
C
Institut Pasteur de Lille, Inserm U.545, Université de Lille 2, Lille, France.
Staels
Bart
B
D000818:Animals; D001683:Biological Clocks / Q000235:genetics; D056926:CLOCK Proteins; D002940:Circadian Rhythm; D004268:DNA-Binding Proteins / Q000378:metabolism; D006331:Heart Diseases / Q000378:metabolism*; D006801:Humans; D008659:Metabolic Diseases / Q000378:metabolism*; D051379:Mice; D008954:Models, Biological; D056953:Nuclear Receptor Subfamily 1, Group D, Member 1; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism; D015534:Trans-Activators / Q000378:metabolism; D014157:Transcription Factors / Q000378:metabolism*
D004268:DNA-Binding Proteins; C498262:Nr1d1 protein, mouse; D056953:Nuclear Receptor Subfamily 1, Group D, Member 1; D018160:Receptors, Cytoplasmic and Nuclear; D015534:Trans-Activators; D014157:Transcription Factors; D056926:CLOCK Proteins; C538943:CLOCK protein, human; C538944:Clock protein, mouse