title: Generalised lymphadenomegaly associated with methimazole treatment in a hyperthyroid cat.
abstract: A nine-year-old, domestic shorthair cat was diagnosed with hyperthyroidism and treated with methimazole, which resulted in lethargy, inappetence and marked generalised lymphadenomegaly within two weeks of initiation of therapy. Cytology, histopathology and immunohistochemistry were suggestive of atypical lymphoid hyperplasia. Cessation of treatment resulted in resolution of all clinical signs and physical abnormalities within two days. Subsequent treatment with radioactive iodine cured this cat of its hyperthyroidism. The lymphadenomegaly did not return at any stage and the cat is currently asymptomatic. Although methimazole administration for feline hyperthyroidism has been associated with many side effects, lymphadenomegaly has, to the authors' knowledge, not been previously reported.
authors.affiliation: Queen Mother Hospital, Royal Veterinary College, University of London, Herts AL9 7TA, UK.
authors.forename: S J M
authors.initials: SJ
authors.lastname: Niessen
authors.forename: M J
authors.initials: MJ
authors.lastname: Voyce
authors.forename: L
authors.initials: L
authors.lastname: de Villiers
authors.forename: J
authors.initials: J
authors.lastname: Hargreaves
authors.forename: A S
authors.initials: AS
authors.lastname: Blunden
authors.forename: H M
authors.initials: HM
authors.lastname: Syme
mesh_terms: D000818:Animals; D013956:Antithyroid Agents / Q000009:adverse effects*; D002371:Cat Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D002415:Cats; D003937:Diagnosis, Differential; D006980:Hyperthyroidism / Q000175:diagnosis / Q000662:veterinary*; D008206:Lymphatic Diseases / Q000139:chemically induced / Q000662:veterinary*; D008297:Male; D008713:Methimazole / Q000009:adverse effects*
chemical_list: D013956:Antithyroid Agents; D008713:Methimazole