[Effect of combined application of the synthetic luteinizing hormone-releasing hormone agonist and nonsteroidal antiandrogen on the reproductive system of male rats].
The influence of combined use of different doses of LGRH agonist (Surfagon) and non-steroidal antiandrogen Flutamide (Niftolid) on the structure and functional state of accessory sexual glands and hypophyseal-gonadal system of rate males had been studied. Optimal ratio of the drug doses for achieving the best antiprostatic effect has been determined. It was shown that combined use of above mentioned drugs resulted in the potentiation of antiprostatic effects. A maximal effect was observed after 30 days of Surfagon administration in a dose of 50 mg/kg b.w. together with flutamid in a dose of 10 mg/kg. b.w. Such a combination of drugs is recommended for clinical approbation as therapy for prostate cancer.
Sachyns'ka
O V
OV
Chaĭkovs'ka
L V
LV
Reznikov
O H
OH
D000726:Androgen Antagonists / Q000494:pharmacology*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D005485:Flutamide / Q000494:pharmacology*; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage / Q000819:agonists / Q000031:analogs & derivatives* / Q000494:pharmacology; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects*; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010913:Pituitary-Adrenal System / Q000187:drug effects*; D011467:Prostate / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar
D000726:Androgen Antagonists; C082465:LHRH ethylamide, des-Gly(10)-Ala(6)-; D007987:Gonadotropin-Releasing Hormone; D005485:Flutamide