Review of the economic and quality-of-life burden of cervical human papillomavirus disease.
OBJECTIVE
The purpose of this study was to conduct a systematic literature review on the economic burden and health-related quality-of-life impact of cervical human papillomavirus disease.


METHODS
A systematic review of cost-of-illness studies and health-related quality-of-life studies was conducted. PubMed, Embase, and PsycINFO databases were searched with the use of predefined terms.


RESULTS
Nine economic and 24 quality-of-life studies were identified. The annual health care costs of human papillomavirus-related conditions in the United States range from 2.25-4.6 billion dollars (2005 US dollars). The burden of human papillomavirus is second only to human immunodeficiency virus among sexually transmitted diseases. Health-related quality-of-life areas that are impacted substantially by human papillomavirus include emotional, social, and sexual functioning.


CONCLUSIONS
The economic and quality-of-life burden of cervical human papillomavirus disease is significant and highlights the need for treatment and prevention options for this condition.
Fleurence
Rachael L
RL
Health Care Analytics Group, United BioSource Corporation, Bethesda, MD, USA. rachael.fleurence@unitedbiosource.com
Dixon
Julia M
JM
Milanova
Tsveta F
TF
Beusterien
Kathleen M
KM
D017281:Cost of Illness; D005260:Female; D006801:Humans; D030361:Papillomavirus Infections / Q000191:economics*; D011788:Quality of Life; D002583:Uterine Cervical Neoplasms / Q000191:economics*