title: Expedient synthesis of substituted (diphenylphosphinoylmethyl)benzenes.
abstract: An efficient protocol for the synthesis of structurally diverse (diphenylphosphinoylmethyl)benzenes is described. The reaction employs readily available carboxylic acids, chlorodiphenylphosphine, and water as the reagents. A 97% reduction in the reaction times and substantially higher yields of products result, up to a 60% increase, if the reactions are performed under microwave irradiation. The first examples of transition-metal-catalyzed reactions applied to 4-bromo-1,3-bis(diphenylphosphinoylmethyl)benzene are also reported.
authors.affiliation: School of Chemical Sciences & Pharmacy, University of East Anglia, Norwich, NR4 7TJ, UK. s.bew@uea.ac.uk
authors.forename: Sean P
authors.initials: SP
authors.lastname: Bew
authors.forename: Rebecca A
authors.initials: RA
authors.lastname: Brimage
authors.forename: David L
authors.initials: DL
authors.lastname: Hughes
authors.forename: Laurent
authors.initials: L
authors.lastname: Legentil
authors.forename: Sunil V
authors.initials: SV
authors.lastname: Sharma
authors.forename: Martin A
authors.initials: MA
authors.lastname: Wilson
mesh_terms: D001555:Benzene Derivatives / Q000138:chemical synthesis / Q000737:chemistry*; D005030:Ethylenes / Q000737:chemistry*; D008872:Microwaves; D015394:Molecular Structure
chemical_list: D001555:Benzene Derivatives; D005030:Ethylenes; C036216:ethylene