title: Enantioselective and diastereoselective Michael addition of ketone/aldehyde to trans-nitroolefins catalyzed by a novel chiral pyrrolidine-thiourea.
abstract: The direct Michael addition reaction of cyclohexanone/aliphatic aldehydes with nitroolefins, catalyzed by a novel chiral pyrrolidine-thiourea catalyst 1a, is described. The desired 1,4-adducts were obtained in moderate yields with enantioselectivities up to 99% ee and dr up to 99:1 of the syn product.
authors.affiliation: Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry and Chemical Engineering, Suzhou University, Suzhou 215123, China.
authors.forename: Zongxuan
authors.initials: Z
authors.lastname: Shen
authors.forename: Yongqiang
authors.initials: Y
authors.lastname: Zhang
authors.forename: Chongjun
authors.initials: C
authors.lastname: Jiao
authors.forename: Bin
authors.initials: B
authors.lastname: Li
authors.forename: Juan
authors.initials: J
authors.lastname: Ding
authors.forename: Yawen
authors.initials: Y
authors.lastname: Zhang