Endoscopic study of the intranasal ostium in external dacryocystorhinostomy postoperative. Influence of saline solution and 5-fluorouracil.
OBJECTIVE
To study, through endoscopy, the postoperative structural changes of the intranasal ostium following external dacryocystorhinostomy and to evaluate the influence of saline solution and 5-fluorouracil.


METHODS
Fifty patients were distributed into the following groups: Group SS-dacryocystorhinostomy and an injection of saline solution during surgery (13 patients); Group 5--FU1-dacryocystorhinostomy and an injection of 5 fluorouracil during surgery (17 patients); Group C--dacryocystorhinostomy only (11 patients); Group 5--FU3-dacryocystorhinostomy and 3 injections, 1 during surgery and 1 on the third and fifth postsurgical days (9 patients).


RESULTS
Pair-wise group comparisons using the nonparametric Mann-Whitney test revealed that there was a significant reduction of the ostium area only in Group 5-FU1 vs. Group SS on the 60th postoperative day (P <.01); however, a comparative study among the 4 groups using the Kruskal-Wallis test showed no significant changes in the ostium area on the 60th postoperative day. The ostium area within groups at the 30th vs 60th postoperative day was significantly reduced for Group C (P < .05; Mann-Whitney test); no significant changes were found for the other groups.


CONCLUSIONS
These results suggest that the use of 5-fluorouracil in external dacryocystorhinostomy does not significantly influence the final size of the surgical fistula as determined 2 months postsurgery.
Costa
Marilisa Nano
MN
State University of Campinas, Campinas, SP, Brasil. m.nano@uol.com.br
Marcondes
Ana Maria
AM
Sakano
Eulalia
E
Kara-José
Newton
N
D000963:Antimetabolites / Q000008:administration & dosage*; D003607:Dacryocystitis / Q000601:surgery*; D003608:Dacryocystorhinostomy / Q000379:methods*; D004724:Endoscopy / Q000379:methods*; D005472:Fluorouracil / Q000008:administration & dosage*; D005500:Follow-Up Studies; D006801:Humans; D009297:Nasal Mucosa / Q000601:surgery; D011184:Postoperative Period; D012008:Recurrence; D012965:Sodium Chloride / Q000008:administration & dosage*; D018709:Statistics, Nonparametric; D016896:Treatment Outcome
D000963:Antimetabolites; D012965:Sodium Chloride; D005472:Fluorouracil