title: Piecewise-quadrilateral registration by optical flow--applications in contrast-enhanced MR imaging of the breast.
abstract: In this paper we propose a method for the nonrigid registration of contrast-enhanced dynamic sequences of magnetic resonance(MR) images. The algorithm has been developed with accuracy in mind, but also has a clinically viable execution time (i.e. a few minutes) as a goal. The algorithm is driven by multiresolution optical flow with the brightness consistency assumption relaxed, subject to a regularized best-fit within a family of transforms. The particular family of transforms we have employed uses a grid of control points and trilinear interpolation. We present validation results from a study simulating non-rigid deformation by a biomechanical model of the breast, with simulated uptake of a contrast agent. We further present results from applying the algorithm as part of a routine breast cancer screening protocol.
authors.affiliation: Department of Medical Biophysics, University of Toronto, Canada. mfroh@swri.ca
authors.forename: Michael S
authors.initials: MS
authors.lastname: Froh
authors.forename: David C
authors.initials: DC
authors.lastname: Barber
authors.forename: Kristy K
authors.initials: KK
authors.lastname: Brock
authors.forename: Donald B
authors.initials: DB
authors.lastname: Plewes
authors.forename: Anne L
authors.initials: AL
authors.lastname: Martel
mesh_terms: D000465:Algorithms; D001185:Artificial Intelligence; D001940:Breast / Q000473:pathology; D001943:Breast Neoplasms / Q000473:pathology*; D003198:Computer Simulation; D003287:Contrast Media; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008954:Models, Biological; D009716:Numerical Analysis, Computer-Assisted; D010363:Pattern Recognition, Automated / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013382:Subtraction Technique
chemical_list: D003287:Contrast Media