Prazosin administered prior to inescapable stressor blocks subsequent exaggeration of acoustic startle response in rats.
Exposure to traumatic stress can result in a number of pathophysiological conditions, including post-traumatic stress disorder (PTSD). PTSD is characterized by a number of persistently heightened physiological and behavioral indicators, including increased sensory arousal and increased startle response. Similar effects can be seen in an animal model of PTSD in which stress results from restraint and inescapable tailshocks to rats. The present study used this animal model to investigate the effects of prazosin, an alpha(1) adrenoceptor antagonist, on stress-induced elevation of acoustic startle response (ASR). To investigate this, male Sprague-Dawley rats were injected with 0.5 mg/kg of prazosin 30 min before restraint and inescapable tail shock on three consecutive days. ASR testing was performed 1, 4, 7 and 10 days post-stress and compared to baseline and control values. Results show a significant reduction of ASR hyperarousal in the group treated with prazosin prior to stress compared to vehicle treated stressed animals and controls. Pre-stress treatment with lower levels of prazosin (0.25, 0.1 and 0.05 mg/kg) showed similar results. These findings further implicate an alpha(1) adrenoceptor role in the pathophysiological response to traumatic stress and suggest a potential preventative role for prazosin.
Manion
Sean T
ST
Neuroscience Program, Department of Psychiatry, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.
Gamble
Eleanore H
EH
Li
He
H
D000317:Adrenergic alpha-Antagonists / Q000008:administration & dosage; D000818:Animals; D004195:Disease Models, Animal; D004597:Electroshock; D004834:Epilepsy, Post-Traumatic / Q000503:physiopathology / Q000517:prevention & control; D008297:Male; D011224:Prazosin / Q000008:administration & dosage*; D051381:Rats; D017207:Rats, Sprague-Dawley; D018340:Receptors, Adrenergic, alpha-1 / Q000502:physiology; D013216:Reflex, Startle / Q000187:drug effects* / Q000502:physiology
D000317:Adrenergic alpha-Antagonists; D018340:Receptors, Adrenergic, alpha-1; D011224:Prazosin