title: [Creatinine clearance estimation in the extremely elderly subjects].
abstract: BACKGROUND
  It has been reported that elderly outpatients take at least 6 different kinds of medication.
  
  
  OBJECTIVE
  To know which formula will best predict creatinine clearance, because 24-hour urine collection is difficult for elderly outpatients.
  
  
  METHODS
  We compared four types of formulae (Cockcroft and Gault, Yasuda, Orita, Walser) to estimate creatinine clearance using serum creatinine of 143 elderly inpatients (73 men, 70 women, mean age 82.9 +/- 8.6 years old) including 67 extremely elderly people with various underlying diseases.
  
  
  RESULTS
  The formula of Cockcroft and Gault showed the best correlation with creatinine clearance in the extremely elderly subjects (r = 0.74) as well as in people under 85 years (r = 0.76). However, the estimated values of the extremely elderly women were lower than actual creatinine clearance.
  
  
  CONCLUSIONS
  The formula of Cockcroft and Gault is the best predictive equation of creatinine clearance, except in the extremely elderly women.
authors.affiliation: Tokyo University of Pharmacy and Life Science.
authors.forename: Shunichi
authors.initials: S
authors.lastname: Hirayama
authors.forename: Reiko
authors.initials: R
authors.lastname: Kikuchi
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Inoue
authors.forename: Daisuke
authors.initials: D
authors.lastname: Tsukahara
authors.forename: Yumi
authors.initials: Y
authors.lastname: Suemitsu
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Kobayashi
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Sugiyama
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Hasegawa
authors.forename: Koichi
authors.initials: K
authors.lastname: Kouzaki
authors.forename: Gosuke
authors.initials: G
authors.lastname: Inoue
authors.forename: Kenji
authors.initials: K
authors.lastname: Toba
mesh_terms: D000369:Aged, 80 and over; D003404:Creatinine / Q000652:urine*; D005260:Female; D006801:Humans; D007677:Kidney Function Tests / Q000379:methods*; D008297:Male; D008657:Metabolic Clearance Rate; D011237:Predictive Value of Tests; D013997:Time Factors
chemical_list: D003404:Creatinine