[Influence of estradiol on hepatic testosterone metabolism in vitro].
The influence of estradiol and of two electron donors (succinate and malate) on testosterone metabolism was studied in vitro. In presence of estradiol the metabolic pattern of testosterone in male liver was changed to a female pattern. On the contrary, addition of malate or succinate to the female liver incubate gave origin to polar metabolites of testosterone which are typical of the male metabolic pattern.
Fonzo
D
D
Department of Medical Pathology and Clinical Methodology, University of Turin, Italy.
Lauro
R
R
De Martinis
C
C
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D057927:Hydrophobic and Hydrophilic Interactions; D066298:In Vitro Techniques; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D051381:Rats; D013739:Testosterone / Q000378:metabolism*
D013739:Testosterone; D004958:Estradiol