Stability of succinylcholine solutions stored at room temperature studied by nuclear magnetic resonance spectroscopy.
The effect of storage temperature on the stability of two succinylcholine chloride solutions (20 and 50 mg/ml) was evaluated. Molecular composition was analysed using nuclear magnetic resonance spectroscopy. At room temperature, the degradation rate constant was 1.2%/month for the 20 mg/ml solution and 2.1%/month for the 50 mg/ml solution. The corresponding monthly degradation rates for the two solutions were 0.18% and 0.30% when stored at 4 degrees C, and 5.4% and 8.1% when stored at 37 degrees C. If a 10% loss of potency is considered acceptable, then the 20 and 50 mg/ml succinylcholine solutions can be stored in emergency resuscitation carts at room temperature for 8.3 and 4.8 months, respectively.
Adnet
Frederic
F
SAMU 93-EA 3409, Hôpital Avicenne, 125, Rue de Stalingrad, 93009 Bobigny Cedex, France. frederic.adnet@avc.aphp.fr
Le Moyec
Laurence
L
Smith
Charles E
CE
Galinski
Michel
M
Jabre
Patricia
P
Lapostolle
Frederic
F
D004355:Drug Stability; D004356:Drug Storage / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy; D009467:Neuromuscular Depolarizing Agents / Q000737:chemistry*; D013390:Succinylcholine / Q000737:chemistry*; D013696:Temperature
D009467:Neuromuscular Depolarizing Agents; D013390:Succinylcholine