Universal laws in the force-induced unraveling of biological bonds.
Universal laws in the force-induced unbinding of receptor-ligand complexes are established for a general functional dependence of the dissociation rate constant on the applied force and are detailed with the two-pathway model that describes the recently discovered biological catch bond. The relationships link the data obtained with constant and time-dependent forces in different regimes, provide common representation for the previously unrelated data sets, and, thereby, greatly facilitate analysis and interpretation of experiments. The universal laws are demonstrated with the monomeric and dimeric catch-slip bonds between P-selectins and P-selectin glycoprotein ligands-1, and the slip bond between E-selectin and sialyl Lewis;{x} antigen.
Pereverzev
Yuriy V
YV
Department of Chemistry, University of Washington, Seattle, Washington 98195-1700, USA.
Prezhdo
Oleg V
OV
D001703:Biophysics / Q000379:methods*; D019040:E-Selectin / Q000737:chemistry*; D008024:Ligands; D008562:Membrane Glycoproteins / Q000737:chemistry*; D015233:Models, Statistical; D008962:Models, Theoretical; D009844:Oligosaccharides / Q000737:chemistry*; D019007:P-Selectin / Q000737:chemistry*; D011312:Pressure; D000080506:Sialyl Lewis X Antigen; D013057:Spectrum Analysis; D013314:Stress, Mechanical; D000267:Tissue Adhesions
D019040:E-Selectin; D008024:Ligands; D008562:Membrane Glycoproteins; D009844:Oligosaccharides; D019007:P-Selectin; C084882:P-selectin ligand protein; D000080506:Sialyl Lewis X Antigen