title: Factors regulating growth hormone secretion in humans.
abstract: Growth hormone (GH) secretion is pulsatile in nature in all species. The periodic pattern of GH release plays an important role in transmitting the GH message in a tissue-specific manner. The question of what regulates the pulsatile GH secretion pattern is an issue of not only theoretical interest but of considerable practical importance for designing different GH therapies for a variety of human diseases. This article provides a brief introductory overview of the different regulators of GH secretion and concentrates primarily on human studies.
authors.affiliation: Division of Metabolism, Endocrinology and Diabetes, 3920 Taubman, Box 0354, University of Michigan Medical Center, Ann Arbor, MI 48109, USA.
authors.forename: Naila
authors.initials: N
authors.lastname: Goldenberg
authors.forename: Ariel
authors.initials: A
authors.lastname: Barkan
mesh_terms: D000818:Animals; D025461:Feedback, Physiological; D005502:Food; D005786:Gene Expression Regulation; D054439:Ghrelin; D012739:Gonadal Steroid Hormones / Q000502:physiology; D007987:Gonadotropin-Releasing Hormone / Q000502:physiology; D013006:Growth Hormone / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008954:Models, Biological; D036361:Peptide Hormones / Q000502:physiology; D012890:Sleep / Q000502:physiology; D013004:Somatostatin / Q000502:physiology
chemical_list: D054439:Ghrelin; D012739:Gonadal Steroid Hormones; D036361:Peptide Hormones; D007987:Gonadotropin-Releasing Hormone; D013004:Somatostatin; D013006:Growth Hormone