The salmochelin siderophore receptor IroN contributes to invasion of urothelial cells by extraintestinal pathogenic Escherichia coli in vitro.
Extraintestinal pathogenic Escherichia coli (ExPEC) strains possess several siderophore-dependent iron uptake systems. In this study we demonstrated that the salmochelin siderophore receptor IroN is involved in the invasion of urothelial cells by ExPEC in vitro. Thus, IroN may play a dual role in the establishment of urinary tract infections, displaying an iron uptake receptor as well as an internalization factor.
Feldmann
Friederike
F
Max von Pettenkofer-Institut für Hygiene und Medizinische Mikrobiologie, Ludwig-Maximilians-Universität München, Marchioninistrasse 17, 81377 Munich, Germany.
Sorsa
Liisa Johanna
LJ
Hildinger
Kirsten
K
Schubert
Sören
S
D001425:Bacterial Outer Membrane Proteins / Q000502:physiology*; D004758:Enterobactin / Q000031:analogs & derivatives* / Q000378:metabolism; D004926:Escherichia coli / Q000472:pathogenicity / Q000502:physiology*; D004927:Escherichia coli Infections / Q000382:microbiology; D029968:Escherichia coli Proteins / Q000235:genetics / Q000502:physiology*; D005960:Glucosides / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000235:genetics / Q000502:physiology*; D014556:Urine / Q000382:microbiology; D019459:Urothelium / Q000382:microbiology* / Q000503:physiopathology
D001425:Bacterial Outer Membrane Proteins; D029968:Escherichia coli Proteins; D005960:Glucosides; C469922:IroN protein, E coli; D011956:Receptors, Cell Surface; C508254:salmochelin S4; C035902:siderophore receptors; D004758:Enterobactin