Domino metathesis of 3,6-dihydro-1,2-oxazine: access to isoxazolo[2,3-a]pyridin-7-ones.
[reaction: see text] Strained bicyclic 3,6-dihydro-1,2-oxazine is a reactive substrate in domino metathesis with an external alkene. This general transformation leads to isoxazolo[2,3-a]pyridin-7-one, a versatile scaffold combining chemical functions that could be selectively oxidized or reduced. The synthetic relevance of these domino metathesis products is demonstrated by a straightforward synthesis of a quinolizinone.
Calvet
Géraldine
G
Laboratoire de Procédés et Substances Naturelles, Institut de Chimie Moléculaire et des Matériaux d'ORSAY, ICMMO - UMR 8182 - Bâtiment 410 Université Paris-Sud XI, 15 rue Georges Clémenceau, 91405 Orsay Cedex, France.
Blanchard
Nicolas
N
Kouklovsky
Cyrille
C