title: Evaluation of carboplatin pharmacokinetics in pediatric oncology by means of inductively coupled plasma mass spectrometry.
abstract: Carboplatin is widely used in pediatric oncology to treat different tumors. Aim of the present study was to assess the potential of sector field inductively coupled plasma mass spectrometry (SF-ICPMS) in evaluating the area under the plasma platinum concentration vs time curve in pediatric patients presenting solid tumors and treated with carboplatin 349-1000 mg m-2. Seventeen patients were enrolled and 23 courses of chemotherapy were evaluated. Plasma was ultrafiltered and free carboplatin was measured in ultrafiltrates as platinum by SF-ICP-MS. Comparison was made between different equations to obtain a target AUC. Limits of detection and of quantification, intra- and inter-day repeatability of the measurements, recovery of the 'free-carboplatin' confirmed SF-ICP-MS as a reliable technique in the quantification of serum platinum in anticancer carboplatin-based therapies.
authors.affiliation: Servizio di Oncologia, Clinica Pediatrica, Università degli Studi La Sapienza, Rome, Italy.
authors.forename: Anna
authors.initials: A
authors.lastname: Clerico
authors.forename: Carlo
authors.initials: C
authors.lastname: Cappelli
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Ragni
authors.forename: Sergio
authors.initials: S
authors.lastname: Caroli
authors.forename: Maria Antonietta
authors.initials: MA
authors.lastname: De Ioris
authors.forename: Alessia
authors.initials: A
authors.lastname: Sordi
authors.forename: Francesco
authors.initials: F
authors.lastname: Petrucci
authors.forename: Beatrice
authors.initials: B
authors.lastname: Bocca
authors.forename: Alessandro
authors.initials: A
authors.lastname: Alimonti
mesh_terms: D000293:Adolescent; D000328:Adult; D000970:Antineoplastic Agents / Q000493:pharmacokinetics* / Q000627:therapeutic use; D019540:Area Under Curve; D001932:Brain Neoplasms / Q000188:drug therapy; D016190:Carboplatin / Q000493:pharmacokinetics* / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D013058:Mass Spectrometry; D009217:Myosarcoma / Q000188:drug therapy; D009369:Neoplasms / Q000188:drug therapy*; D009379:Neoplasms, Muscle Tissue / Q000188:drug therapy; D010984:Platinum / Q000032:analysis*; D012208:Rhabdomyosarcoma / Q000188:drug therapy
chemical_list: D000970:Antineoplastic Agents; D010984:Platinum; D016190:Carboplatin