title: Evaluation of left ventricular Tei index (index of myocardial performance) in healthy dogs and dogs with mitral regurgitation.
abstract: The left ventricular (LV) Tei index (index of myocardial performance) has been demonstrated to be clinically useful in estimating comprehensive LV function, including the systolic and diastolic performances, in various human cardiac diseases. The purposes of this study were to validate the correlation between the LV Tei index and LV function obtained by cardiac catheterization in healthy dogs, and to evaluate the LV Tei index in dogs with naturally occurring mitral regurgitation (MR). In healthy dogs, the LV Tei index was significantly correlated with the LV peak +dP/dt (r = -0.89) and LV peak -dP/dt (r=0.87). The LV Tei index significantly increased in dogs with MR compared with normal dogs and significantly increased with progressively more severe clinical signs due to heart failure. The elevation of the LV Tei index in dogs with symptomatic MR appears to be associated with shortening of ejection time. The LV Tei index significantly increased with age and was not correlated with heart rate and body weight in normal dogs. In conclusion, our study demonstrated that the LV Tei index was measurable in dogs and not influenced by heart rate and body weight. The LV Tei index significantly increased with the progression of clinical signs in MR dogs. In particular, the elevation of the LV Tei index in dogs with symptomatic MR due to shortening of ejection time may suggest LV systolic dysfunction and the decrement of forward stroke volume.
authors.affiliation: Laboratory of Veterinary Surgery, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, Fujisawa, Kanagawa, Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Teshima
authors.forename: Kazushi
authors.initials: K
authors.lastname: Asano
authors.forename: Koji
authors.initials: K
authors.lastname: Iwanaga
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Koie
authors.forename: Masami
authors.initials: M
authors.lastname: Uechi
authors.forename: Yuka
authors.initials: Y
authors.lastname: Kato
authors.forename: Kenji
authors.initials: K
authors.lastname: Kutara
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Kanno
authors.forename: Mamiko
authors.initials: M
authors.lastname: Seki
authors.forename: Kazuya
authors.initials: K
authors.lastname: Edamura
authors.forename: Atsuhiko
authors.initials: A
authors.lastname: Hasegawa
authors.forename: Shigeo
authors.initials: S
authors.lastname: Tanaka
mesh_terms: D000367:Age Factors; D000818:Animals; D001835:Body Weight; D006328:Cardiac Catheterization / Q000662:veterinary; D004283:Dog Diseases / Q000175:diagnosis / Q000503:physiopathology*; D004285:Dogs / Q000502:physiology*; D018619:Echocardiography, Doppler, Pulsed / Q000662:veterinary*; D005260:Female; D006339:Heart Rate; D008944:Mitral Valve Insufficiency / Q000175:diagnosis / Q000503:physiopathology / Q000662:veterinary*; D016277:Ventricular Function, Left / Q000502:physiology*