title: Association between serotonin transporter availability and hostility scores in healthy volunteers - a single photon emission computed tomography study with [(123)I] ADAM.
abstract: The present study examined the relationship between serotonin transporter (SERT) availability and hostility scores in healthy volunteers. SERT availability was measured by using SPECT with [(123)I] ADAM in 10 healthy participants. Hostility was measured with the Cook-Medley Hostility Scale. Hostile attribution, but not the other subscales of hostility, was negatively correlated with SERT availability. Central serotoninergic activities may play a role in hostility.
authors.affiliation: Department of Psychiatry, College of Medicine, National Cheng Kung University, 138 Sheng Li Road, Tainan 70403, Taiwan. ykyang@mail.ncku.edu.tw
authors.forename: Yen Kuang
authors.initials: YK
authors.lastname: Yang
authors.forename: Wei Jen
authors.initials: WJ
authors.lastname: Yao
authors.forename: Tzung Lieh
authors.initials: TL
authors.lastname: Yeh
authors.forename: I Hui
authors.initials: IH
authors.lastname: Lee
authors.forename: Kao Ching
authors.initials: KC
authors.lastname: Chen
authors.forename: Ru Band
authors.initials: RB
authors.lastname: Lu
mesh_terms: D000328:Adult; D001921:Brain / Q000378:metabolism*; D002928:Cinanserin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D005260:Female; D006791:Hostility; D006801:Humans; D007275:Injections, Intravenous; D007457:Iodine Radioisotopes / Q000008:administration & dosage / Q000493:pharmacokinetics; D008297:Male; D050486:Serotonin Plasma Membrane Transport Proteins / Q000378:metabolism*; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: C413491:2-((2-((dimethylamino)methyl)phenyl)thio)-5-iodophenylamine; D007457:Iodine Radioisotopes; D050486:Serotonin Plasma Membrane Transport Proteins; D002928:Cinanserin