Prospective, randomized trial of metformin and vitamins for the reduction of plasma homocysteine in insulin-resistant polycystic ovary syndrome.
One hundred and two women with insulin-resistant polycystic ovary syndrome were randomized to treatment with a vitamin B preparation, metformin, or both, in conjunction with standard infertility treatment. Plasma homocysteine levels were significantly reduced by both B vitamins and metformin, but to a greater degree by B vitamins, and higher pregnancy rates were associated with vitamin B treatment.
Schachter
Morey
M
In Vitro Fertilization and Infertility Unit, Assaf Harofeh Medical Center, Tel Aviv University, Zerifin, Israel. ivfdoc@asaf.health.gov.il
Raziel
Arieh
A
Strassburger
Devorah
D
Rotem
Carmela
C
Ron-El
Raphael
R
Friedler
Shevach
S
D000328:Adult; D005260:Female; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D008687:Metformin / Q000627:therapeutic use*; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000188:drug therapy; D011446:Prospective Studies; D014815:Vitamins / Q000627:therapeutic use*
D014815:Vitamins; D006710:Homocysteine; D008687:Metformin