title: Eosinophilic pneumonia due to duloxetine.
abstract: A 32-year-old man presented with a 2-month history of worsening fever, chills, and cough despite therapy with oral antibiotics. Chest radiographs demonstrated migrating, peripheral upper lobe infiltrates. A CBC count demonstrated significant eosinophilia. At bronchoscopy, eosinophil-rich mucus was seen impacted throughout his bronchi. A transbronchial biopsy confirmed the diagnosis of eosinophilic pneumonia. Symptoms, eosinophilia, and radiographic abnormalities were reversed with cessation of duloxetine. This case report briefly reviews the diagnosis of drug-induced pulmonary infiltrates with eosinophilia (PIEs) and eosinophilic pneumonia. To our knowledge, this is the first reported case of PIEs due to duloxetine.
authors.affiliation: Division of Pulmonary/Critical Care Medicine,Stony Brook University, Stony Brook, NY.
authors.forename: Vidal J
authors.initials: VJ
authors.lastname: Espeleta
authors.affiliation: Departments of Radiology, Stony Brook University, Stony Brook, NY.
authors.forename: William H
authors.initials: WH
authors.lastname: Moore
authors.affiliation: Pathology, Stony Brook University, Stony Brook, NY.
authors.forename: Philip B
authors.initials: PB
authors.lastname: Kane
authors.affiliation: Division of Pulmonary/Critical Care Medicine,Stony Brook University, Stony Brook, NY.. Electronic address: daniel.baram@stonybrook.edu.
authors.forename: Daniel
authors.initials: D
authors.lastname: Baram
mesh_terms: D000328:Adult; D000928:Antidepressive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001706:Biopsy; D001999:Bronchoscopy; D018549:Cryptogenic Organizing Pneumonia / Q000139:chemically induced / Q000175:diagnosis / Q000473:pathology; D003937:Diagnosis, Differential; D000068736:Duloxetine Hydrochloride; D006801:Humans; D008168:Lung / Q000187:drug effects / Q000473:pathology; D008297:Male; D011657:Pulmonary Eosinophilia / Q000139:chemically induced* / Q000175:diagnosis / Q000473:pathology; D013876:Thiophenes / Q000009:adverse effects* / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed
chemical_list: D000928:Antidepressive Agents; D013876:Thiophenes; D000068736:Duloxetine Hydrochloride