title: Fertility restoration by the cryopreservation of oocytes and ovarian tissue from the position of biomedical ethics: a review.
abstract: The loss of fertility as a consequence of chemoradiotherapy is a considerable problem. It can affect the psychological equilibrium and quality of life for women cancer survivors. In recent years, the possibility of cryopresenrvation of ovarian tissue following auto transplantation, opens new promise in the attempt to restore fertility. In addition to psychological and ethical concerns of this procedure, there are risks of retransplantation of tumor cells and recurrence of malignancy. In this review we will focus on the most recent achievements in cryopreservation of oocytes and ovarian tissue and will attempt to answer questions about the safety and effectiveness of restoration of fertility by cryopreservation of oocytes or ovarian tissue.
authors.affiliation: Institute of Bioethics, Catholic University of Sacred Heart, Roma 00168, Italy. serebrovska@yahoo.com
authors.forename: Zoya
authors.initials: Z
authors.lastname: Serebrovska
authors.forename: Tatiana
authors.initials: T
authors.lastname: Serebrovskaya
authors.forename: Maria Luisa
authors.initials: ML
authors.lastname: Di Pietro
authors.forename: Rebecca
authors.initials: R
authors.lastname: Pyle
mesh_terms: D000818:Animals; D026688:Bioethical Issues; D015925:Cryopreservation / Q000941:ethics; D005260:Female; D005298:Fertility / Q000941:ethics / Q000502:physiology*; D005307:Fertilization in Vitro; D006801:Humans; D009369:Neoplasms / Q000503:physiopathology; D009865:Oocytes / Q000502:physiology*; D010053:Ovary / Q000502:physiology* / Q000637:transplantation; D018456:Reproductive Medicine / Q000941:ethics*; D012306:Risk