Anti-MAG/SGPG associated neuropathy does not commonly cause distal nerve temporal dispersion.
Patients with anti-myelin associated glycoprotein (anti-MAG) neuropathy have uniform slowing without temporal dispersion, but do usually have disproportionately distal slowing. We evaluated distal compound muscle action potential (CMAP) dispersion in 29 patients with anti-MAG/sulphated glucuronyl paragloboside (SGPG) neuropathy (titres > or = 12,800). Among 138 motor responses, 15% (tibial), 7.3% (peroneal), 10.7% (median) and 13.8% (ulnar) had distal CMAP duration > 9 ms. Disproportionate distal slowing with normal distal CMAP duration in the arms may be useful to differentiate chronic inflammatory demyelinating polyneuropathy from anti-MAG/SGPG associated neuropathy.
Gondim
F A A
FA
Department of Neurology, Weill Medical College of Cornell University, New York, NY, USA.
De Sousa
E A
EA
Latov
N
N
Sander
H W
HW
Chin
R L
RL
Brannagan
T H
TH
D000200:Action Potentials; D000906:Antibodies; D001132:Arm / Q000502:physiology; D004594:Electrophysiology; D005260:Female; D005915:Globosides / Q000276:immunology; D006801:Humans; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000503:physiopathology*; D018992:Myelin-Associated Glycoprotein / Q000276:immunology*; D011115:Polyneuropathies / Q000276:immunology / Q000503:physiopathology*; D012189:Retrospective Studies
D000906:Antibodies; D005915:Globosides; D018992:Myelin-Associated Glycoprotein; C051917:sulfate-3-glucuronyl paragloboside