Triterpene saponins from Bacopa monnieri and their antidepressant effects in two mice models.
Three new triterpene glycosides, bacopasides VI-VIII (1-3), together with three known analogues, bacopaside I (4), bacopaside II (5), and bacopasaponsin C (6), were isolated from the whole plant of Bacopa monnieri. Compounds 4, 5, and 6 showed antidepressant activity when tested on forced swimming and tail suspension in mice, respectively.
Zhou
Yun
Y
Department of Phytochemistry, College of Pharmacy, Second Military Medical University, Shanghai 200433, People's Republic of China.
Shen
Yun-Heng
YH
Zhang
Chuan
C
Su
Juan
J
Liu
Run-Hui
RH
Zhang
Wei-Dong
WD
D000818:Animals; D000928:Antidepressive Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D034681:Bacopa / Q000737:chemistry*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D051379:Mice; D023421:Models, Animal; D010946:Plants, Medicinal / Q000737:chemistry*; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
D000928:Antidepressive Agents; D004365:Drugs, Chinese Herbal; D012503:Saponins; D014315:Triterpenes; C519753:bacopaside VI; C519754:bacopaside VII; C519755:bacopaside VIII