Confabulations in episodic memory are associated with delusions in Alzheimer's disease.
Although confabulations and delusions are observed in Alzheimer's disease, the relationship between the 2 has not been fully investigated. This study involved 50 patients with Alzheimer's disease and 10 healthy participants. After the patients were divided into delusional and nondelusional groups, confabulations and cognitive function were assessed. No confabulations appeared in the healthy participants, and only patients with Alzheimer's disease showed confabulations. The delusional group produced more confabulations on episodic subjects than on semantic subjects. There was a correlation between cognitive impairment and confabulations in semantic memory. These findings suggest that different mechanisms are involved in confabulations between semantic and episodic memories.
Lee
Eunjoo
E
Department of Behavioral Neurology and Cognitive Neuro-science, Tohoku University Graduate School of Medicine, Sendai, Japan.
Meguro
Kenichi
K
Hashimoto
Ryusaku
R
Meguro
Mitsue
M
Ishii
Hiroshi
H
Yamaguchi
Satoshi
S
Mori
Etsuro
E
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000175:diagnosis* / Q000523:psychology; D000647:Amnesia / Q000175:diagnosis* / Q000523:psychology; D003702:Delusions / Q000175:diagnosis* / Q000523:psychology; D005260:Female; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000175:diagnosis / Q000523:psychology; D011939:Mental Recall; D009483:Neuropsychological Tests; D012016:Reference Values; D012094:Repression, Psychology