title: Nuclear actions in innate immune signaling.
abstract: Innate immunity in plants and animals is mediated through pattern recognition receptors, which were thought to initiate signaling in the cytoplasm to activate defense pathways. Shen et al. (2006) and Burch-Smith et al. (2007) now provide compelling evidence that certain plant disease resistance proteins, which detect specific pathogenic effectors, act in the nucleus to trigger downstream signaling and defense pathways.
authors.affiliation: Department of Molecular Biology, Massachusetts General Hospital, Department of Genetics, Harvard Medical School, Boston, MA 02114, USA. sheen@molbio.mgh.harvard.edu
authors.forename: Jen
authors.initials: J
authors.lastname: Sheen
authors.forename: Ping
authors.initials: P
authors.lastname: He
mesh_terms: D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism*; D001467:Hordeum / Q000276:immunology / Q000378:metabolism; D007113:Immunity, Innate; D010935:Plant Diseases / Q000276:immunology*; D010944:Plants / Q000276:immunology* / Q000378:metabolism; D051192:Receptors, Pattern Recognition / Q000378:metabolism*; D015398:Signal Transduction; D014026:Nicotiana / Q000276:immunology / Q000378:metabolism
chemical_list: D051192:Receptors, Pattern Recognition