title: Simultaneous onset of type 1 diabetes in monozygotic twins younger than 1 year.
abstract: This report describes type 1 insulin deficient diabetes mellitus (IDDM) arising in identical twins aged under one year. One twin presented with symptoms and was diagnosed with type 1 IDDM; the diagnosis of type 1 IDDM was simultaneously made in the second twin without clinical symptoms. Both twins were positive for anti-GAD (glutamic acid decarboxylase) antibody at first, and then positive for islet cell antibodies. Interestingly, the twins have four susceptible HLA DR and DQ genes together that are usually recognized separately in IDDM patients in Japan.
authors.affiliation: Department of Pediatrics, Nagano Red Cross Hospital, Wakasato 5-22-1, Nagano, 380-8582, Japan.
authors.forename: Noriko
authors.initials: N
authors.lastname: Uchida
authors.forename: Yoshiro
authors.initials: Y
authors.lastname: Amano
authors.forename: Yohei
authors.initials: Y
authors.lastname: Akazawa
authors.forename: Shinichi
authors.initials: S
authors.lastname: Nakamura
authors.forename: Isaki
authors.initials: I
authors.lastname: Minami
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Washizawa
authors.forename: Yasunobu
authors.initials: Y
authors.lastname: Wakabayashi
authors.forename: Kozo
authors.initials: K
authors.lastname: Yasui
mesh_terms: D001323:Autoantibodies / Q000097:blood; D003922:Diabetes Mellitus, Type 1 / Q000175:diagnosis / Q000235:genetics / Q000276:immunology; D004200:Diseases in Twins / Q000175:diagnosis / Q000235:genetics / Q000276:immunology; D005260:Female; D005968:Glutamate Decarboxylase / Q000276:immunology; D006684:HLA-DR Antigens; D006801:Humans; D007223:Infant; D007515:Islets of Langerhans / Q000276:immunology; D013997:Time Factors; D014430:Twins, Monozygotic
chemical_list: D001323:Autoantibodies; D006684:HLA-DR Antigens; D005968:Glutamate Decarboxylase