Biological active macrocyclic diterpenoids from chinese drug "Fáng Féng Cáo"; II. Derivatives of ovatodiolids and their cytotoxity.
Isolated macrocyclic diterpenoids, ovatodiolide ( 1), 4, 5-epoxyovatodiolide ( 2), anisomelic acid ( 3), 4, 7-oxycycloanisomelic acid ( 4), and 4-methylene-5-oxoanisomelic acid ( 6), from the Chinese crude drug "Fáng Féng Cáordquo;, and the derivatives of the isolated compounds were tested for their growth inhibiting activities in culture of KB cell line. Besides, the effects of 1 on Ehrlich carcinoma in mice are reported.
Arisawa
M
M
Department of Medicinal Resources, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930-01, Japan.
Nimura
M
M
Fujita
A
A
Hayashi
T
T
Morita
N
N
Koshimura
S
S