title: Drug-induced myoclonus: a French pharmacovigilance database study.
abstract: Various drugs have been reported to induce myoclonus. However, this adverse event is not well known because of the difficult diagnosis and the lack of pharmaco-epidemiological or controlled studies. As far as we know, there are only case reports. In the literature, antiparkinsonian medications, antipsychotics, antidepressants, anesthetics, opiates and anti-infectious drugs have been reported in the occurrence of myoclonus. In a French pharmacovigilance database study, only 423 reports (0.2%) involved drug-induced myoclonus. The median age of patients was 55 years and 10% of these patients had a concomitant neurological disease. Only 16% of these reports had a strong imputability score (likely). The most frequently involved drugs were anti-infectious (15%), antidepressants (15%), anxiolytics (14%), and opiates agents (12%). Fifty-six percent of these reports were classified as serious adverse event. Concerning outcome, most patients (84%) recovered without sequels.
authors.affiliation: Service de pharmacologie, faculté de médecine, 37, allées Jules-Guesde, 31000 Toulouse, France. brefel@cict.fr
authors.forename: C
authors.initials: C
authors.lastname: Brefel-Courbon
authors.forename: V
authors.initials: V
authors.lastname: Gardette
authors.forename: F
authors.initials: F
authors.lastname: Ory
authors.forename: J L
authors.initials: JL
authors.lastname: Montastruc
mesh_terms: D000328:Adult; D016907:Adverse Drug Reaction Reporting Systems / Q000706:statistics & numerical data; D000368:Aged; D015984:Causality; D015897:Comorbidity; D016208:Databases, Factual; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009207:Myoclonus / Q000139:chemically induced* / Q000453:epidemiology / Q000209:etiology; D009422:Nervous System Diseases / Q000150:complications; D004364:Pharmaceutical Preparations / Q000145:classification
chemical_list: D004364:Pharmaceutical Preparations