title: Serum amyloid A levels are increased in pre-eclampsia.
abstract: OBJECTIVE
  The purpose of this study was to examine serum amyloid A (SAA) levels in normal pregnant and pre-eclamptic women.
  
  
  METHODS
  SAA levels were measured in 25 normotensive and 25 pre-eclamptic pregnant women by enzyme linked immuno-sorbent assay.
  
  
  RESULTS
  In pre-eclampsia, SAA level and C-reactive protein (CRP) averaged 28.2 (7.2-135) ng/l and 21 (6.13-91) mg/l, respectively, which were significantly higher than those of normal pregnancy (7.8 [4.65-24.6] ng/l and 6.05 [0.3-19] mg/l, respectively) (p < 0.05). In addition, SAA level was positively correlated to CRP (r = 0.468, p < 0.05).
  
  
  CONCLUSIONS
  Marked increases of both SAA level and CRP in pre-eclampsia, and their inter-relation, may at least in part contribute to the pathogenesis of pre-eclampsia.
authors.affiliation: Department of Obstetrics and Gynecology, School of Medicine, Inonu University, Malatya, Turkey. ustunyaprak@yahoo.com
authors.forename: Yaprak
authors.initials: Y
authors.lastname: Engin-Ustün
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Ustün
authors.forename: Aysun Bay
authors.initials: AB
authors.lastname: Karabulut
authors.forename: Esra
authors.initials: E
authors.lastname: Ozkaplan
authors.forename: M Mutlu
authors.initials: MM
authors.lastname: Meydanli
authors.forename: Ayşe
authors.initials: A
authors.lastname: Kafkasli
mesh_terms: D000328:Adult; D001724:Birth Weight; D002097:C-Reactive Protein / Q000378:metabolism*; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D005260:Female; D005865:Gestational Age; D006801:Humans; D011225:Pre-Eclampsia / Q000097:blood* / Q000473:pathology; D011247:Pregnancy / Q000097:blood*; D000685:Serum Amyloid A Protein / Q000032:analysis*
chemical_list: D000685:Serum Amyloid A Protein; D002097:C-Reactive Protein