Biodegradable dextran hydrogels for protein delivery applications.
The rapid development of protein-based pharmaceuticals over recent decades has tremendously increased the need for suitable delivery systems, guaranteeing a safe and controlled delivery of proteinacious drugs. Hydrogels offer good opportunities as protein delivery systems or tissue engineering scaffolds owing to an inherent biocompatibility. Their hydrophilic, soft and rubbery nature ensures minimal tissue irritation and a low tendency of cells and proteins to adhere to the hydrogel surface. A variety of both natural and synthetic polymers have been used for the design of hydrogels, in which network formation is established by chemical or physical crosslinking. This review introduces the general features of hydrogels and focuses on dextran hydrogels in particular. Chemically and physically crosslinked systems are described and their potential suitability as protein delivery systems, as well as tissue engineering scaffolds are discussed. Special attention is given to network properties, protein delivery, degradation behavior and biocompatibility.
Van Tomme
Sophie R
SR
Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, University of Utrecht, PO Box 80082, 3508 TB Utrecht, The Netherlands. s.r.vantomme@pharm.uu.nl
Hennink
Wim E
WE
D020341:Absorbable Implants; D003911:Dextrans / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems / Q000379:methods*; D020100:Hydrogels / Q000737:chemistry*; D011506:Proteins / Q000008:administration & dosage / Q000627:therapeutic use*
D003911:Dextrans; D004337:Drug Carriers; D020100:Hydrogels; D011506:Proteins