Ultrastructure of skeletal muscle capillaries under conditions of space mission.
Capillaries of the rat forepaw skeletal muscles were examined on day 14 of space mission and on days 1 and 14 after landing. Ultrastructural studies revealed apoptosis caused by muscle fiber atrophy and necrobiotic changes eventuating in coagulation or monocellular necrosis of endothelial cells. Formation of capillaries was detected, which can be regarded as an adaptive reaction to injuries caused by space mission factors.
Volodina
A V
AV
Laboratory of Pathomorphology, Institute of Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow. niiopp@mail.ru
Pozdnyakov
O M
OM
D000818:Animals; D017209:Apoptosis / Q000502:physiology; D002196:Capillaries / Q000648:ultrastructure*; D042783:Endothelial Cells / Q000473:pathology; D008854:Microscopy, Electron; D018482:Muscle, Skeletal / Q000098:blood supply*; D009133:Muscular Atrophy / Q000473:pathology; D009336:Necrosis / Q000473:pathology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013026:Space Flight; D014893:Weightlessness