[Effects of growth factors on periodontal ligament cells].
OBJECTIVE
To evaluate the effects of the polypeptide growth factors on the periodontal ligament cell (PDLC) based on a comprehensive review on the literature concerned.


METHODS
The recent literature related to the effects of the polypeptide growth factors on the PDLC were extensively and comprehensively reviewed and a corresponding evaluation was made.


RESULTS
The proliferation and the multi-directional differentiation of the PDLC were found to be the basis for the regeneration of the periodontal tissues. The effects of the polypeptide growth factors on the function of the PDLC became a hot issue of the research on the regeneration of the periodontal tissues. The polypeptide growth factors were found to play an important role in the migration, growth, proliferation, differentiation, and synthesis of protein and matrix of the PDLC.


CONCLUSIONS
The polypeptide growth factors can be used in the periodontal regeneration treatment, but a further research is still required to improve this kind of treatment.
Zhao
Huan
H
West China Collage of Stomatology, Sichuan University, Chengdu Sichuan, 610041, P. R. China. zhao_huan@tom.com
Ding
Yi
Y
Yang
He
H
D000818:Animals; D019485:Bone Morphogenetic Proteins / Q000494:pharmacology; D002448:Cell Adhesion / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000494:pharmacology*; D010513:Periodontal Ligament / Q000166:cytology* / Q000187:drug effects* / Q000502:physiology; D010982:Platelet-Derived Growth Factor / Q000494:pharmacology; D012038:Regeneration / Q000187:drug effects*; D053773:Transforming Growth Factor beta1 / Q000494:pharmacology
D019485:Bone Morphogenetic Proteins; D036341:Intercellular Signaling Peptides and Proteins; D010982:Platelet-Derived Growth Factor; D053773:Transforming Growth Factor beta1