title: Nanoporous magnesium aluminometasilicate tablets for precise, controlled, and continuous dosing of chemical reagents and catalysts: applications in parallel solution-phase synthesis.
abstract: Mechanically robust tablets of nanoporous magnesium aluminometasilicate with high surface area and porosity can be loaded with a variety of organic and inorganic reagents and catalysts. The scope of this novel dosing methodology is demonstrated through the evaluation of 14 diverse organic reactions, including Mitsunobu, Suzuki, and bromination reactions.
authors.affiliation: Early Lead Generation, Medicinal Chemistry Research, H. Lundbeck A/S, 9 Ottiliavej, DK-2500 Valby, Denmark. tr@lundbeck.com
authors.forename: Thomas
authors.initials: T
authors.lastname: Ruhland
authors.forename: Simon D
authors.initials: SD
authors.lastname: Nielsen
authors.forename: Per
authors.initials: P
authors.lastname: Holm
authors.forename: Claus H
authors.initials: CH
authors.lastname: Christensen
mesh_terms: D017607:Aluminum Compounds; D000538:Aluminum Silicates / Q000737:chemistry*; D002384:Catalysis; D007202:Indicators and Reagents / Q000737:chemistry*; D008274:Magnesium / Q000737:chemistry*; D017616:Magnesium Compounds; D036103:Nanotechnology; D017640:Silicates
chemical_list: D017607:Aluminum Compounds; D000538:Aluminum Silicates; D007202:Indicators and Reagents; D017616:Magnesium Compounds; D017640:Silicates; C033065:aluminum magnesium silicate; D008274:Magnesium