title: Hysteresis and bistability in a realistic cell model for calcium oscillations and action potential firing.
abstract: Many cells reveal oscillatory behavior. Some cells reveal action-potential firing resulting from Hodgkin-Huxley (HH) type dynamics of ion channels in the cell membrane. Another type of oscillation relates to periodic inositol triphospate (IP3)-mediated calcium transients in the cytosol. In this study we present a bifurcation analysis of a cell with an excitable membrane and an IP3-mediated intracellular calcium oscillator. With IP3 concentration as a control parameter the model reveals a complex, rich spectrum of both stable and unstable solutions with hysteresis corresponding to experimental data. Our results reveal the emergence of complex behavior due to interactions between subcomponents with a relatively simple dynamical behavior.
authors.affiliation: Department of Biophysics, Radboud University Nijmegen, 6525 EZ Nijmegen, The Netherlands.
authors.forename: J M A M
authors.initials: JM
authors.lastname: Kusters
authors.forename: J M
authors.initials: JM
authors.lastname: Cortes
authors.forename: W P M
authors.initials: WP
authors.lastname: van Meerwijk
authors.forename: D L
authors.initials: DL
authors.lastname: Ypey
authors.forename: A P R
authors.initials: AP
authors.lastname: Theuvenet
authors.forename: C C A M
authors.initials: CC
authors.lastname: Gielen
mesh_terms: D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000502:physiology*; D020013:Calcium Signaling / Q000502:physiology*; D002460:Cell Line; D002462:Cell Membrane / Q000502:physiology*; D003198:Computer Simulation; D015544:Inositol 1,4,5-Trisphosphate / Q000378:metabolism; D015640:Ion Channel Gating / Q000502:physiology; D007687:Kidney Tubules, Proximal / Q000378:metabolism; D008564:Membrane Potentials / Q000502:physiology; D008954:Models, Biological; D051381:Rats
chemical_list: D015220:Calcium Channels; D015544:Inositol 1,4,5-Trisphosphate; D002118:Calcium