Synapse-specific reconsolidation of distinct fear memories in the lateral amygdala.
When reactivated, memories enter a labile, protein synthesis-dependent state, a process referred to as reconsolidation. Here, we show in rats that fear memory retrieval produces a synaptic potentiation in the lateral amygdala that is selective to the reactivated memory, and that disruption of reconsolidation is correlated with a reduction of synaptic potentiation in the lateral amygdala. Thus, both retrieval and reconsolidation alter memories via synaptic plasticity at selectively targeted synapses.
Doyère
Valérie
V
Neurobiologie de l'Apprentissage, de la Mémoire et de la Communication (NAMC), Centre National de la Recherche Scientifique (CNRS), UMR8620, Université Paris-Sud, 91405 Orsay, France.
Debiec
Jacek
J
Monfils
Marie-H
MH
Schafe
Glenn E
GE
LeDoux
Joseph E
JE
D000161:Acoustic Stimulation / Q000379:methods; D000679:Amygdala / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D000704:Analysis of Variance; D000818:Animals; D001522:Behavior, Animal; D002070:Butadienes / Q000494:pharmacology; D003214:Conditioning, Classical / Q000187:drug effects / Q000502:physiology*; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005239:Fear; D008297:Male; D008568:Memory / Q000187:drug effects / Q000502:physiology*; D009570:Nitriles / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D011930:Reaction Time / Q000502:physiology / Q000528:radiation effects; D013569:Synapses / Q000187:drug effects / Q000502:physiology*
D002070:Butadienes; D004791:Enzyme Inhibitors; D009570:Nitriles; C113580:U 0126