[Effects of rh-GH on the remodeling of periodontium in the ovariectomized rats after orthodontic tooth movement].
OBJECTIVE
To investigate the effects of the recombinant human growth hormone (rh-GH) on the periodontal cells in the ovariectomized rats after orthodontic tooth movement.


METHODS
Thirty seven-week-old SPF female Wistar rats were randomly divided into three groups: the control group, the ovariectomy-saline group (OVX-NS group) and the variectomy-GH group(OVX-GH group). Different treatments, including variectomy and injecting normal saline solution, were adminstrated on the rats of the three groups. The number of osteoclast in the compressed alveolar bone was counted on the fifteenth and thirtieth days. Histological changes were observed. The data was analyzed with ANOVA by SPSS12.0 software package.


RESULTS
By ANOVA analysis, there were significant differences in the number of osteoclast between the three groups in the same period. The number of osteoclast in the compressed alveolar bone of OVX-NS group was significantly more than that of the OVX-GH group (P < 0.05), and that of the control group was the least. In the same group, there wasn't significant difference between the rats killed 15 days later and 30 days later (P > 0.05). The trauma and inflammation of periodontal membrane of OVX-GH group had been significantly improved compared with the OVX-NS group.


CONCLUSIONS
It is suggested that injecting rh-GH can decrease the number of osteoclast in the compressed alveolar bone in the adult rats after orthodontic tooth movement. At the same time, it can improve the recovery of pathologic changes of periodontal tissue caused by the orthodontic force. There will be a synergetic effect between adult orthodontic treatment and rh-GH.
Zhang
Jun
J
Department of Orthodontics, School of Stomatology, Shandong University, Jinan 250012, Shandong Province, China.
Wang
Sheng-Llin
SL
Wang
Xu-Xia
XX
Huang
Yan
Y
Zhang
Wen-Juan
WJ
D000539:Alveolar Process; D000818:Animals; D005260:Female; D019382:Human Growth Hormone / Q000494:pharmacology*; D010010:Osteoclasts / Q000187:drug effects*; D010052:Ovariectomy; D010513:Periodontal Ligament / Q000187:drug effects*; D010519:Periodontium / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D014087:Tooth Movement Techniques
D019382:Human Growth Hormone