title: Anti-p19 antibody treatment exacerbates lyme arthritis and enhances borreliacidal activity.
abstract: Considerable effort has been made to elucidate the mechanism of Lyme arthritis. We focused on p19, a cell cycle-regulating molecule, because it is known to inhibit cell cycle division of T lymphocytes which may be responsible for the induction of arthritis. We show that anti-p19 antibody treatment enhances the inflammatory response normally detected at the tibiotarsal joints of Borrelia burgdorferi-vaccinated and Borrelia bissettii-challenged mice. Specifically, anti-p19 antibody treatment augmented the severity of inflammation within the synovial and subsynovial tissue. Moreover, treatment with anti-p19 antibody caused severe erosion of cartilage and bone with ankle joint destruction. In addition, anti-p19 antibody treatment of Borrelia-vaccinated and -challenged mice enhanced the borreliacidal antibody response, especially against the vaccine isolate. The novel activities of anti-p19 antibody show that p19 may be an important therapeutic site for the treatment of Lyme arthritis.
authors.affiliation: University of Wisconsin, Wisconsin State Laboratory of Hygiene, Department of Bacteriology, and Department of Pathology, Veterans Administration Hospital, Madison, WI 53706, USA.
authors.forename: Sara Heil
authors.initials: SH
authors.lastname: Peterson
authors.forename: Dean T
authors.initials: DT
authors.lastname: Nardelli
authors.forename: Thomas F
authors.initials: TF
authors.lastname: Warner
authors.forename: Steven M
authors.initials: SM
authors.lastname: Callister
authors.forename: Jose R
authors.initials: JR
authors.lastname: Torrealba
authors.forename: Ronald F
authors.initials: RF
authors.lastname: Schell
mesh_terms: D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood*; D000911:Antibodies, Monoclonal / Q000494:pharmacology*; D025065:Borrelia burgdorferi / Q000276:immunology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D018797:Cell Cycle Proteins / Q000276:immunology*; D005260:Female; D008193:Lyme Disease / Q000097:blood / Q000276:immunology* / Q000473:pathology; D022123:Lyme Disease Vaccines / Q000494:pharmacology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D014611:Vaccination
chemical_list: D000907:Antibodies, Bacterial; D000911:Antibodies, Monoclonal; D018797:Cell Cycle Proteins; D022123:Lyme Disease Vaccines