Neurocognitive sequelae of pediatric sickle cell disease: a review of the literature.
This literature review summarizes all studies relating neuropsychological performance to neuroimaging findings in pediatric sickle cell disease (N=28; published 1991-2005). Although inconsistencies exist within and across domains, deficits in intelligence (IQ), attention and executive functions, memory, language, visuomotor abilities, and academic achievement have been identified. Overall neurocognitive compromise was revealed to be related to the level of neurological injury and the location of silent infarct. Attentional and executive dysfunction is prevalent and related to frontal lobe abnormalities.
Berkelhammer
Leslie D
LD
Division of Behavioral Medicine, St. Jude Children's Research Hospital. Memphis, TN 38105-2794, USA. leslie.berkelhammer@stjude.org
Williamson
Adrienne L
AL
Sanford
Stacy D
SD
Dirksen
Courtney L
CL
Sharp
William G
WG
Margulies
Allison S
AS
Prengler
Rebecca A
RA
D000755:Anemia, Sickle Cell / Q000150:complications* / Q000175:diagnosis / Q000534:rehabilitation; D001925:Brain Damage, Chronic / Q000175:diagnosis / Q000209:etiology* / Q000534:rehabilitation; D002648:Child; D003072:Cognition Disorders / Q000175:diagnosis / Q000209:etiology* / Q000534:rehabilitation; D004522:Educational Status; D006801:Humans; D007360:Intelligence; D009483:Neuropsychological Tests; D011379:Prognosis