title: Effect of substance P on thermoregulation parameters during different cooling modes.
abstract: The modulatory effect of ionophoretic application of substance P to the skin on the formation of the cold-triggered thermal protection reactions depends on the rate of cooling. During rapid cooling substance P enhances heat production, while during slow cooling it promotes constriction of skin blood vessels aimed at reduction of heat emission.
authors.affiliation: Laboratory of Thermophysiology, Institute of Physiology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk.
authors.forename: E Ya
authors.initials: EY
authors.lastname: Tkachenko
authors.forename: V P
authors.initials: VP
authors.lastname: Kozaruk
authors.forename: T V
authors.initials: TV
authors.lastname: Kozyreva
mesh_terms: D000818:Animals; D001831:Body Temperature; D001833:Body Temperature Regulation / Q000187:drug effects* / Q000502:physiology; D003080:Cold Temperature; D008297:Male; D010101:Oxygen Consumption / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D012867:Skin / Q000098:blood supply / Q000187:drug effects*; D013373:Substance P / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D013373:Substance P