title: Secondary metabolites from Commiphora opobalsamum and their antiproliferative effect on human prostate cancer cells.
abstract: A cycloartane-type triterpenoid (1), an aliphatic alcohol glycoside (2), an eudesmane-type sesquiterpenoid (3), and a guaiane-type sesquiterpenoid (4) were isolated from the resinous exudates of Commiphora opobalsamum along with six known sesquiterpenoids (5-10). Their structures were established by extensive analysis of their 1D and 2D NMR spectroscopic data and chemical methods. The isolated compounds 1-3 and 5-9 were tested against human prostate cancer cell PC 3 and LNCaP. Among them, 1 and 2 showed moderate antiproliferative effects on human prostate cancer cell lines with IC50 values ranging from 5.7 to 23.6 microM; they were also able to inhibit the expression of androgen receptor (AR) in LNCaP cells. The six sesquiterpenoids were inactive in the bioassays.
authors.affiliation: Department of Natural Products Chemistry, School of Pharmaceutical Sciences, Shandong University, 44 West Wenhua Road, Jinan 250012, PR China.
authors.forename: Tao
authors.initials: T
authors.lastname: Shen
authors.forename: Wenzhu
authors.initials: W
authors.lastname: Wan
authors.forename: Huiqing
authors.initials: H
authors.lastname: Yuan
authors.forename: Feng
authors.initials: F
authors.lastname: Kong
authors.forename: Huaifang
authors.initials: H
authors.lastname: Guo
authors.forename: Peihong
authors.initials: P
authors.lastname: Fan
authors.forename: Hongxiang
authors.initials: H
authors.lastname: Lou
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D029744:Commiphora / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D008297:Male; D015394:Molecular Structure; D011471:Prostatic Neoplasms / Q000188:drug therapy / Q000473:pathology*; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D013729:Terpenes