[Effects of Chinese Bushen Zhuanggu medicine on bone loss in female rats after simulated weightlessness].
OBJECTIVE
To study the effect of Bushen Zhuanggu, the traditional Chinese medicine for reinforcing kidney and strengthening bone, on bone loss in female rats after simulated weightlessness.


METHODS
Thirty-six female SD rats were randomly divided into 3 groups, namely normal control group (group A) and two groups of weightlessness simulated by tail suspension (groups B and C). Group C were treated with the Chinese medicine, while groups A and B were given the same dose of normal saline. The experiment lasted 28 days, and all rats were allowed to drink water freely.


RESULTS
In the rats of group B, serum bone Gla protein (BGP), alkaline phosphatase (ALP), estradiol (E(2)) and P content and femur bone mineral content (BMD) were significantly lower than those in group A (P<0.01, P<0.05), whereas serum calcium concentration was markedly higher than that in group A (P<0.01). In rats of group C, serum BGP, ALP, E2 and P content and femur BMD were significantly higher than those in group B (P<0.01, P<0.05), but serum calcium concentration was markedly lower (P<0.01).


CONCLUSIONS
This Chinese prescription can stimulate bone formation and reduce bone loss in female rats subjected to simulated weightlessness.
Sun
Ping
P
Department of Endocrinology, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China. sing_ping@163.com
Huang
Zhen
Z
Cai
De-Hong
DH
He
Lei
L
D000818:Animals; D015519:Bone Density / Q000187:drug effects; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D010024:Osteoporosis / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D018474:Weightlessness Simulation / Q000009:adverse effects*
D004365:Drugs, Chinese Herbal; C528816:bushen zhuanggu