title: Selected important fragrance sensitizers in perfumes--current exposures.
abstract: Contact allergy to fragrance ingredients is frequent. Recommendations and regulations of some of the most frequent and potent fragrance allergens have recently been introduced. To investigate current exposures to 4 important fragrance allergens in hydroalcoholic cosmetic products. 25 popular perfume products of Danish as well as international brands were purchased from the Danish retail market. Contents of 4 important fragrance allergens, isoeugenol, hydroxy-iso-hexyl 3-cyclohexene carboxaldehyde (HICC, Lyral), were determined by gas chromatography-mass spectrometry, and atranol and chloro-atranol were determined by liquid chromatography-tandem mass spectrometry. Isoeugenol was found in 56%, HICC in 72%, atranol in 59%, and chloro-atranol in 36% of the 22 eau de toilette/eau de parfum products. The concentrations of isoeugenol were, in all products, below the recommended maximum concentration of 0.02%. HICC reached a maximum of 0.2%, which is 10-fold higher than maximum tolerable concentration considered safe by the EU Scientific Committee. The median concentrations of atranol and chloro-atranol in the investigated products were similar to those found in similar products in 2003. A significant decrease in the frequency of presence of chloro-atranol in the products was observed. There is still a wide-spread exposure to potent fragrance allergens in perfumes.
authors.affiliation: Department of Environmental Chemistry and Microbiology, National Environmental Research Institute, Frederiksborgvej 399, DK-4000 Roskilde, Denmark. scr@dmu.dk
authors.forename: Suresh Chandra
authors.initials: SC
authors.lastname: Rastogi
authors.forename: Jeanne Duus
authors.initials: JD
authors.lastname: Johansen
authors.forename: Rossana
authors.initials: R
authors.lastname: Bossi
mesh_terms: D000447:Aldehydes / Q000032:analysis; D000485:Allergens / Q000032:analysis*; D001547:Benzaldehydes / Q000032:analysis; D002853:Chromatography, Liquid; D053138:Cyclohexenes / Q000032:analysis; D003718:Denmark; D017449:Dermatitis, Allergic Contact / Q000209:etiology*; D005054:Eugenol / Q000031:analogs & derivatives / Q000032:analysis; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D010476:Perfume / Q000737:chemistry*
chemical_list: D000447:Aldehydes; D000485:Allergens; D001547:Benzaldehydes; D053138:Cyclohexenes; D010476:Perfume; C493895:atranol; C487450:chloroatranol; D005054:Eugenol; C036643:isoeugenol; C092244:hydroxyisohexyl 3-cyclohexene carboxaldehyde