title: Recombinant granulocyte-macrophage colony-stimulating factor in the treatment of indolent ulcers with Klippel-Trénaunay-Weber syndrome: a case report.
abstract: Klippel-Trénaunay-Weber syndrome (KTWS) is a rare congenital disease characterized by cutaneous hemangiomata, venous varicosities and osseous soft tissue hypertrophy of the affected limb. We report a case of a patient with KTWS who had developed severe chronic, non-healing cutaneous ulcers resulting from several angiography procedures with embolization by various agents. The ulcers were treated with perilesional granulocyte-macrophage colony-stimulating-factor (GM-CSF) with gratifying results. This case report suggests that GM-CSF may enhance the healing of chronic wounds not responding to other treatment modalities in patients with congenital angiodystrophy syndromes, thus salvaging a limb from amputation.
authors.affiliation: Research Integrity Office, University of Louisville Hospital, Louisville, KY 40202, USA. furqansi@ulh.org
authors.forename: Furqan H
authors.initials: FH
authors.lastname: Siddiqui
authors.forename: Moinuddin H
authors.initials: MH
authors.lastname: Mokhashi
authors.forename: Abdullah
authors.initials: A
authors.lastname: Boathman
mesh_terms: D002648:Child; D005260:Female; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D007715:Klippel-Trenaunay-Weber Syndrome / Q000150:complications*; D007871:Leg Ulcer / Q000188:drug therapy* / Q000209:etiology; D011994:Recombinant Proteins; D014945:Wound Healing / Q000187:drug effects
chemical_list: D011994:Recombinant Proteins; D016178:Granulocyte-Macrophage Colony-Stimulating Factor