title: The use of vasopressin in the setting of recalcitrant hypotension due to calcium channel blocker overdose.
abstract: Treatment of hypotension caused by calcium channel blocker overdose (CCB) remains a challenge. We describe the successful use of vasopressin in two patients with massive CCB overdoses in whom hypotension was unresponsive to calcium, glucagon, insulin, and conventional vasopressor therapies. While various modes of treatments have been used to treat the hypotension of CCB overdose, this is the first report to our knowledge of the successful use of vasopressin in this clinical setting.
authors.affiliation: Coney Island Hospital, Brooklyn, New York 11235, USA.
authors.forename: Karthikeyan
authors.initials: K
authors.lastname: Kanagarajan
authors.forename: Jeanna M
authors.initials: JM
authors.lastname: Marraffa
authors.forename: Nicole C
authors.initials: NC
authors.lastname: Bouchard
authors.forename: Padmanabhan
authors.initials: P
authors.lastname: Krishnan
authors.forename: Robert S
authors.initials: RS
authors.lastname: Hoffman
authors.forename: Christine M
authors.initials: CM
authors.lastname: Stork
mesh_terms: D000328:Adult; D017311:Amlodipine / Q000009:adverse effects; D000931:Antidotes / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D002121:Calcium Channel Blockers / Q000009:adverse effects*; D003975:Diazepam / Q000494:pharmacology; D004110:Diltiazem / Q000009:adverse effects; D062787:Drug Overdose; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007022:Hypotension / Q000139:chemically induced* / Q000188:drug therapy*; D008875:Middle Aged; D016896:Treatment Outcome; D014662:Vasoconstrictor Agents / Q000627:therapeutic use*; D014667:Vasopressins / Q000627:therapeutic use*
chemical_list: D000931:Antidotes; D002121:Calcium Channel Blockers; D014662:Vasoconstrictor Agents; D014667:Vasopressins; D017311:Amlodipine; D004110:Diltiazem; D003975:Diazepam