title: Mechanisms of leukemogenesis induced by bovine leukemia virus: prospects for novel anti-retroviral therapies in human.
abstract: In 1871, the observation of yellowish nodules in the enlarged spleen of a cow was considered to be the first reported case of bovine leukemia. The etiological agent of this lymphoproliferative disease, bovine leukemia virus (BLV), belongs to the deltaretrovirus genus which also includes the related human T-lymphotropic virus type 1 (HTLV-1). This review summarizes current knowledge of this viral system, which is important as a model for leukemogenesis. Recently, the BLV model has also cast light onto novel prospects for therapies of HTLV induced diseases, for which no satisfactory treatment exists so far.
authors.affiliation: Molecular and Cellular Biology, Faculté Universitaire des Sciences Agronomiques, Gembloux, Belgium. gillet.n@fsagx.ac.be
authors.forename: Nicolas
authors.initials: N
authors.lastname: Gillet
authors.forename: Arnaud
authors.initials: A
authors.lastname: Florins
authors.forename: Mathieu
authors.initials: M
authors.lastname: Boxus
authors.forename: Catherine
authors.initials: C
authors.lastname: Burteau
authors.forename: Annamaria
authors.initials: A
authors.lastname: Nigro
authors.forename: Fabian
authors.initials: F
authors.lastname: Vandermeers
authors.forename: Hervé
authors.initials: H
authors.lastname: Balon
authors.forename: Amel-Baya
authors.initials: AB
authors.lastname: Bouzar
authors.forename: Julien
authors.initials: J
authors.lastname: Defoiche
authors.forename: Arsène
authors.initials: A
authors.lastname: Burny
authors.forename: Michal
authors.initials: M
authors.lastname: Reichert
authors.forename: Richard
authors.initials: R
authors.lastname: Kettmann
authors.forename: Luc
authors.initials: L
authors.lastname: Willems
mesh_terms: D000818:Animals; D044966:Anti-Retroviral Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001402:B-Lymphocytes / Q000473:pathology / Q000502:physiology / Q000821:virology; D002417:Cattle; D016207:Cytokines / Q000378:metabolism; D004195:Disease Models, Animal; D016583:Enzootic Bovine Leukosis / Q000188:drug therapy* / Q000503:physiopathology / Q000821:virology; D015368:Human T-lymphotropic virus 1 / Q000472:pathogenicity; D006801:Humans; D001909:Leukemia Virus, Bovine / Q000235:genetics / Q000378:metabolism / Q000472:pathogenicity*; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000188:drug therapy* / Q000503:physiopathology; D007963:Leukocytes, Mononuclear / Q000473:pathology / Q000502:physiology / Q000821:virology; D012756:Sheep; D012757:Sheep Diseases / Q000188:drug therapy* / Q000276:immunology / Q000503:physiopathology / Q000821:virology; D014764:Viral Proteins / Q000235:genetics / Q000378:metabolism
chemical_list: D044966:Anti-Retroviral Agents; D016207:Cytokines; D014764:Viral Proteins