[Concentrations of soluble forms of adhesive particles: sVCAM-1, sPECAM-1, sVAP in early localized and late disseminated borreliosis].
OBJECTIVE
Serum concentration of sVCAM-1, sPECAM- i sVAP in Lyme borreliosis patients with early localized-erythema migrans (EM) and disseminated Lyme arthritis (LA), before and after treatment were estimated.


METHODS
Twenty subjects with EM, and 20 persons with LA were enrolled to examinations. Control group consisted of 10 healthy blood donors. Concentrations of sVCAM-1, sPECAM- and sVAP were performed with ELISA kits (Bender Med. System) Statistic analysis were performer with ANSTAT i Statistica PI, programs as well ROC curves.


RESULTS
In group of early localized Lyme borreliosis essentially increase of serum concentrations of sVCAM and sPECAM were stated, in late, disseminated (LA), essentially increase of sVAP concentration was stated.


CONCLUSIONS
Measurement of serum concentrations of soluble forms some adhesion molecules In liquid compartments can be a potential marker of disease activity, and differentiation among Early localized and late disseminated stages of Lyme borreliosis.
Zajkowska
Joanna
J
Department of Inectious Diseases and Neuroinfections, Medical University of Białystok, Poland. neuroin@amb.edu.pl
Grygorczuk
Sambor
S
Kondrusik
Maciej
M
Pancewicz
Sławomir
S
Jamiołkowski
Jacek
J
Muszyńska
Agnieszka
A
Hermanowska-Szpakowicz
Teresa
T
D006631:Amine Oxidase (Copper-Containing) / Q000097:blood*; D000818:Animals; D015415:Biomarkers / Q000097:blood; D015815:Cell Adhesion Molecules / Q000097:blood*; D005260:Female; D006801:Humans; D008193:Lyme Disease / Q000097:blood* / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D019408:Platelet Endothelial Cell Adhesion Molecule-1 / Q000097:blood*; D012995:Solubility; D013987:Ticks; D019010:Vascular Cell Adhesion Molecule-1 / Q000097:blood*
D015415:Biomarkers; D015815:Cell Adhesion Molecules; D019408:Platelet Endothelial Cell Adhesion Molecule-1; D019010:Vascular Cell Adhesion Molecule-1; C076668:AOC3 protein, human; D006631:Amine Oxidase (Copper-Containing)