[Osteoporosis and atherosclerosis].
Many epidemiological studies have shown an association between osteoporosis and vascular calcification or atherosclerotic diseases (coronary heart disease, stroke, peripheral vascular disease) in the elderly or postmenopausal women. These results indicate that osteoporosis and atherosclerosis might be linked by common risk factors or pathological mechanisms. Dyslipidemia has the correlation to both osteoporosis and atherosclerosis. Statins, nitorogen-containing bisphosphonates, and estrogens have the favorable effects on lipid profiles as well as vasculature, or bone mineral density. Thus, these therapeutic approaches might have dual effects on bone and vasculature.
Omura
Yasushi
Y
Shiga University of Medical Science, Department of Medicine, Division of Endocrinology and Metabolism.
Nishio
Yoshihiko
Y
Kashiwagi
Atsunori
A
D050197:Atherosclerosis / Q000188:drug therapy / Q000453:epidemiology / Q000209:etiology*; D015519:Bone Density; D004164:Diphosphonates / Q000627:therapeutic use; D050171:Dyslipidemias / Q000150:complications* / Q000188:drug therapy / Q000453:epidemiology; D004967:Estrogens / Q000627:therapeutic use; D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D008297:Male; D010024:Osteoporosis / Q000188:drug therapy* / Q000453:epidemiology / Q000209:etiology*; D012307:Risk Factors
D004164:Diphosphonates; D004967:Estrogens; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors