Free radical trapping properties of several ethyl-substituted derivatives of 5-ethoxycarbonyl-5-methyl-1-pyrroline N-oxide (EMPO).
The spin trapping behavior of several ethyl-substituted EMPO derivatives, cis- and trans-5-ethoxycarbonyl-3-ethyl-5-methyl-pyrroline N-oxide (3,5-EEMPO), 5-ethoxycarbonyl-4-ethyl-5-methyl-pyrroline N-oxide (4,5-EEMPO), cis- and trans-5-ethoxycarbonyl-5-ethyl-3-methyl-pyrroline N-oxide (5,3-EEMPO), and 5-ethoxycarbonyl-5-ethyl-4-methyl-pyrroline N-oxide (5,4-EEMPO), toward a series of different oxygen- and carbon-centered radicals, is described. Considerably different stabilities of the superoxide adducts (ranging from about 12 to 55 min) as well as the formation of other radical adducts were observed.
Stolze
Klaus
K
Molecular Pharmacology and Toxicology Unit, Department of Natural Science, University of Veterinary Medicine Vienna, Veterinärplatz 1, A-1210 Vienna, Austria. Klaus.Stolze@vu-wien.ac.at
Rohr-Udilova
Natascha
N
Rosenau
Thomas
T
Hofinger
Andreas
A
Nohl
Hans
H
D002384:Catalysis; D003497:Cyclic N-Oxides / Q000138:chemical synthesis* / Q000494:pharmacology*; D004578:Electron Spin Resonance Spectroscopy; D016166:Free Radical Scavengers / Q000138:chemical synthesis* / Q000494:pharmacology*; D006207:Half-Life; D017665:Hydroxyl Radical / Q000737:chemistry; D007202:Indicators and Reagents; D007501:Iron; D008054:Lipid Peroxides / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D000432:Methanol / Q000737:chemistry; D021241:Spectrometry, Mass, Electrospray Ionization; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared; D019097:Spin Trapping; D013481:Superoxides / Q000737:chemistry
C408629:5-ethoxycarbonyl-5-methyl-1-pyrroline N-oxide; D003497:Cyclic N-Oxides; D016166:Free Radical Scavengers; D007202:Indicators and Reagents; D008054:Lipid Peroxides; D013481:Superoxides; D017665:Hydroxyl Radical; D007501:Iron; D000432:Methanol