The interactions of cobalt(II) with mitochondria from rat liver.
The interactions of Co(2+) with mitochondria have been investigated. The results indicate that Co(2+) inhibits ATP synthesis. Further investigations into ATP synthesis mechanisms indicated that inhibition is due to the opening of a transmembrane pore. The opening of this pore causes the collapse of the high-energy intermediate where, under a pH and a potential gradient, the energy is stored and subsequently utilized to form ATP from ADP.
Bragadin
Marcantonio
M
Dipartimento di Scienze Ambientali, Università Cà Foscari, Venezia DD 2137, 30123 Venice, Italy. bragadin@unive.it
Toninello
Antonio
A
Mancon
Mario
M
Manente
Sabrina
S
D000244:Adenosine Diphosphate / Q000378:metabolism; D000251:Adenosine Triphosphatases / Q000037:antagonists & inhibitors / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000096:biosynthesis; D000818:Animals; D002952:Citric Acid Cycle / Q000502:physiology; D003035:Cobalt / Q000737:chemistry*; D004579:Electron Transport / Q000187:drug effects / Q000502:physiology; D004734:Energy Metabolism / Q000502:physiology; D004791:Enzyme Inhibitors / Q000494:pharmacology; D007202:Indicators and Reagents; D008930:Mitochondria, Liver / Q000737:chemistry*; D051336:Mitochondrial Membranes / Q000737:chemistry; D010101:Oxygen Consumption / Q000502:physiology; D010539:Permeability; D051381:Rats; D017208:Rats, Wistar; D013056:Spectrophotometry, Ultraviolet
D004791:Enzyme Inhibitors; D007202:Indicators and Reagents; D003035:Cobalt; D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate; D000251:Adenosine Triphosphatases