HIV-1 subtype D infection is associated with faster disease progression than subtype A in spite of similar plasma HIV-1 loads.
We investigated the effect of human immunodeficiency virus type 1 (HIV-1) subtype on disease progression among 145 Kenyan women followed from the time of HIV-1 acquisition. Compared with those infected with subtype A, women infected with subtype D had higher mortality (hazard ratio, 2.3 [95% confidence interval, 1.0-5.6]) and a faster rate of CD4 cell count decline (P=.003). The mortality risk persisted after adjustment for plasma HIV-1 load. There were no differences in plasma viral load by HIV-1 subtype during follow-up. HIV-1 subtype D infection is associated with a >2-fold higher risk of death than subtype A infection, in spite of similar plasma HIV-1 loads.
Baeten
Jared M
JM
Department of Medicine, University of Washington, Seattle, WA, USA.
Chohan
Bhavna
B
Lavreys
Ludo
L
Chohan
Vrasha
V
McClelland
R Scott
RS
Certain
Laura
L
Mandaliya
Kishorchandra
K
Jaoko
Walter
W
Overbaugh
Julie
J
D000328:Adult; D018791:CD4 Lymphocyte Count; D004279:DNA, Viral / Q000097:blood; D018450:Disease Progression; D005260:Female; D015483:HIV Antibodies / Q000097:blood; D015658:HIV Infections / Q000401:mortality* / Q000503:physiopathology / Q000821:virology*; D015497:HIV-1 / Q000145:classification* / Q000235:genetics / Q000276:immunology / Q000472:pathogenicity*; D006801:Humans; D053208:Kaplan-Meier Estimate; D007630:Kenya; D012307:Risk Factors; D013997:Time Factors; D019562:Viral Load
D004279:DNA, Viral; D015483:HIV Antibodies