title: Tooth development: 2. Regenerating teeth in the laboratory.
abstract: Tooth loss can occur for a number of reasons and a variety of prosthetic tooth replacement solutions are available to the dental practitioner. This article discusses current approaches in the use of tissue engineering to replace teeth or repair dental tissues. These strategies will depend upon the manipulation of stem cells in the laboratory and, whilst much progress has recently been made, it is likely that successful human tooth regeneration is still some years ahead.
authors.affiliation: Department of Orthodontics and Craniofacial Development, Floor 22, Guy's Hospital, GKT Dental Institute, King's College London, UK.
authors.forename: Obinna
authors.initials: O
authors.lastname: Onyekwelu
authors.forename: Maisa
authors.initials: M
authors.lastname: Seppala
authors.forename: Maria
authors.initials: M
authors.lastname: Zoupa
authors.forename: Martyn T
authors.initials: MT
authors.lastname: Cobourne
mesh_terms: D053687:Adult Stem Cells / Q000502:physiology; D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D003782:Dental Pulp / Q000166:cytology; D003809:Dentin, Secondary / Q000502:physiology; D053595:Embryonic Stem Cells / Q000502:physiology; D006801:Humans; D008648:Mesoderm / Q000166:cytology; D009804:Odontoblasts / Q000166:cytology / Q000502:physiology; D009805:Odontogenesis / Q000502:physiology*; D039904:Pluripotent Stem Cells / Q000502:physiology; D012038:Regeneration / Q000502:physiology; D023822:Tissue Engineering / Q000379:methods*