title: OspC phylogenetic analyses support the feasibility of a broadly protective polyvalent chimeric Lyme disease vaccine.
abstract: Using available Borrelia outer surface protein C (OspC) sequences, a phylogenetic analysis was undertaken to delineate the number of antigenic domains required for inclusion in a broadly protective, chimeric, OspC-based Lyme disease vaccine. The data indicate that approximately 34 would be required and that an OspC-based vaccinogen is feasible.
authors.affiliation: Department of Microbiology and Immunology, Center for the Study of Biological Complexity, Medical College of Virginia at Virginia Commonwealth University, Richmond, VA 23298-0678, USA.
authors.forename: Christopher G
authors.initials: CG
authors.lastname: Earnhart
authors.forename: Richard T
authors.initials: RT
authors.lastname: Marconi
mesh_terms: D000595:Amino Acid Sequence; D000942:Antigens, Bacterial / Q000032:analysis / Q000276:immunology*; D001425:Bacterial Outer Membrane Proteins / Q000032:analysis / Q000276:immunology*; D005240:Feasibility Studies; D006801:Humans; D008193:Lyme Disease / Q000517:prevention & control*; D022123:Lyme Disease Vaccines / Q000276:immunology*; D008969:Molecular Sequence Data; D010802:Phylogeny
chemical_list: D000942:Antigens, Bacterial; D001425:Bacterial Outer Membrane Proteins; D022123:Lyme Disease Vaccines; C079616:OspC protein