title: Comparison of hemodynamic and respiratory effects of propofol and sevoflurane during carbon dioxide pneumoperitoneum in a swine model.
abstract: The aim of this study was to compare intraoperative hemodynamic and respiratory parameters using propofol and sevoflurane during laparoscopic surgery in a porcine model. After induction of general anaesthesia in 16 pigs with fentanyl (0.005 mg kg(-1)) followed by propofol (6 mg Kg(-1)), it was maintained with fentanyl (0.01 mg kg(-1)h(-1)) and sevoflurane in O2 in group 1 (G1, n = 8) and fentanyl and propofol (12 mg kg(-1)h(-1)) in group 2 (G2, n = 8). The parameters monitored were heart rate, airway pressure (PAW), arterial and venous blood pressures and arterial blood gas analysis. The carbon dioxide pneumoperitoneum was maintained at 12 mmHg for 2 hours. Data were expressed as mean +/- standard deviation and were analysed using the Wilcoxon test (p < 0.05). G1 showed significantly higher PAW values than G2 at T60, T90 and T120. The heart rate values were significantly higher in G1 at T90 and T120. Middle arterial pressure was significantly lower in G1 than G2 at T30 and T60. The base deficit was significantly greater in G1 at T60, T90, T120 and Tpost. In this study propofol assured better hemodynamic and respiratory conditions than sevoflurane during laparoscopy in a porcine model.
authors.affiliation: General Surgery and Liver Transplantation Unit, Department of Emergency and Organ Transplantation, University of Bari Medical School, Bari, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Puglisi
authors.forename: Antonio
authors.initials: A
authors.lastname: Crovace
authors.forename: Francesco
authors.initials: F
authors.lastname: Staffieri
authors.forename: Palma
authors.initials: P
authors.lastname: Capuano
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Carravetta
authors.forename: Michele
authors.initials: M
authors.lastname: De Fazio
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Lograno
authors.forename: Luca
authors.initials: L
authors.lastname: Lacitignola
authors.forename: Vito Leopoldo
authors.initials: VL
authors.lastname: Troilo
authors.forename: Gennaro
authors.initials: G
authors.lastname: Martines
authors.forename: Carmine
authors.initials: C
authors.lastname: Chiumarulo
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Memeo
mesh_terms: D019162:Anesthetics, Combined / Q000008:administration & dosage / Q000494:pharmacology*; D018685:Anesthetics, Inhalation / Q000008:administration & dosage / Q000494:pharmacology; D018686:Anesthetics, Intravenous / Q000008:administration & dosage / Q000494:pharmacology; D000818:Animals; D001784:Blood Gas Analysis / Q000379:methods; D001794:Blood Pressure / Q000187:drug effects*; D002245:Carbon Dioxide; D004195:Disease Models, Animal; D006339:Heart Rate / Q000187:drug effects*; D010535:Laparoscopy / Q000379:methods; D008738:Methyl Ethers / Q000008:administration & dosage / Q000494:pharmacology*; D011028:Pneumoperitoneum, Artificial; D015742:Propofol / Q000008:administration & dosage / Q000494:pharmacology*; D011659:Pulmonary Gas Exchange / Q000187:drug effects*; D000077149:Sevoflurane; D018709:Statistics, Nonparametric; D013552:Swine
chemical_list: D019162:Anesthetics, Combined; D018685:Anesthetics, Inhalation; D018686:Anesthetics, Intravenous; D008738:Methyl Ethers; D002245:Carbon Dioxide; D000077149:Sevoflurane; D015742:Propofol