Chemokines.
Chemokines are a family of polypeptides that direct the migration of leukocytes toward a site of infection. They play a major role in autoimmune disease and chemokine receptors have recently been found to mediate HIV-1 fusion. In this short review we examine the role of chemokines in host defence and in the pathophysiology of autoimmune diseases. We conclude by discussing various therapeutic approaches that target chemokine receptors and that could be beneficial in disease.
Horuk
Richard
R
Department of Immunology, Berlex Biosciences, Richmond, CA, USA. Horuk@pacbell.net
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D001327:Autoimmune Diseases / Q000188:drug therapy* / Q000276:immunology*; D018925:Chemokines / Q000276:immunology*; D006801:Humans; D007155:Immunologic Factors / Q000276:immunology*; D018448:Models, Immunological; D019707:Receptors, Chemokine / Q000037:antagonists & inhibitors* / Q000276:immunology*
D000893:Anti-Inflammatory Agents; D018925:Chemokines; D007155:Immunologic Factors; D019707:Receptors, Chemokine