title: [Sequelae and quality of life in young adult survivors of childhood cancer].
abstract: OBJECTIVE
  The long-term survival rate of childhood cancer is around 70%, but cancer- and treatment-related sequelae and the risk of a second malignancy may impair the survivors' quality of life.
  
  
  METHODS
  Fifty-four patients older than 18 years, treated for a cancer between 1988 and 1996, and considered as cured for at least 5 years, were asked to participate. Data on cancer, treatment and sequelae were extracted from the Rhône-Alpes childhood cancer registry and from the medical charts. Health-related quality of life was assessed with the SF-36 scale. Lifestyle, educational level, present occupation, subjective health, and worries were assessed with a detailed questionnaire.
  
  
  RESULTS
  Forty-three young adult patients participated (16 female, 27 male, mean age 23 [range: 18-32]). Primary cancers were leukaemias (35%), lymphomas (19%), solid tumors (34%) and central nervous system tumors (12%). Nine percent of the subjects had received cranio-spinal radiotherapy, and 14% a total body irradiation followed by bone marrow transplantation. Two patients (5%) had developed a second malignancy, 30% have an endocrine insufficiency, 14% have neurological or psychological impairment, and 21% have orthopaedic sequelae. Health-related quality of life of the population as a whole, as assessed by SF-36, is close to normative data published for healthy population of that age. Female gender, certain types of cancer (neuroblastoma, bone tumors and carcinomas), and the presence of endocrine sequelae are predictors of a worse quality of life. Only 3 patients (7%) declared having had to shorten their education because of their cancer; 63% are currently employed, 25% are students or apprentices. Worries about fertility are often mentioned; half of the subjects declare having received no formal instruction about their medical follow-up in adult age.
  
  
  CONCLUSIONS
  Although the quality of life of young adult survivors of childhood cancer as a whole does not seem very much altered, many of these survivors experience adverse sequelae warranting medical and psychological attention. Some of their preoccupations, such as worries about reproductive capacity and inheritability of their cancer, are often ignored.
authors.affiliation: Service de Médecine Interne, CHU, Hôpital Nord, 42055 Saint-Etienne cedex 02, France.
authors.forename: A-G
authors.initials: AG
authors.lastname: Chaume
authors.forename: C
authors.initials: C
authors.lastname: Berger
authors.forename: P
authors.initials: P
authors.lastname: Cathébras
mesh_terms: D000328:Adult; D017668:Age of Onset; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000145:classification / Q000523:psychology*; D016609:Neoplasms, Second Primary / Q000453:epidemiology / Q000523:psychology; D011788:Quality of Life; D015203:Reproducibility of Results; D017741:Survivors / Q000523:psychology / Q000706:statistics & numerical data*