JAK2V617F detection and dosage of serum erythropoietin: first steps of the diagnostic work-up for patients consulting for elevated hematocrit.
The predictive values of common biological criteria for the diagnosis of polycythemia vera were studied in a cohort of patients with high hematocrit. We found JAK2V617F and erythropoietin assays were the most relevant first tests. Classification of patients according to their JAK2V617F status and erythropoietin levels facilitated the choice of further diagnostic investigations.
Girodon
François
F
Lippert
Eric
E
Mossuz
Pascal
P
Dobo
Irène
I
Boiret-Dupré
Nathalie
N
Lesesve
Jean-François
JF
Hermouet
Sylvie
S
Praloran
Vincent
V
D019943:Amino Acid Substitution; D015331:Cohort Studies; D003937:Diagnosis, Differential; D004921:Erythropoietin / Q000097:blood*; D005260:Female; D005787:Gene Frequency; D006400:Hematocrit; D006801:Humans; D053614:Janus Kinase 2 / Q000097:blood / Q000235:genetics*; D008297:Male; D050505:Mutant Proteins / Q000097:blood / Q000235:genetics*; D020125:Mutation, Missense; D017354:Point Mutation; D011086:Polycythemia / Q000097:blood / Q000175:diagnosis; D011087:Polycythemia Vera / Q000097:blood / Q000175:diagnosis* / Q000201:enzymology / Q000235:genetics; D011237:Predictive Value of Tests
D050505:Mutant Proteins; D004921:Erythropoietin; C507924:JAK2 protein, human; D053614:Janus Kinase 2