Cytokines pattern after surgical radiofrequency ablation of liver colorectal metastases.
OBJECTIVE
The aim of this study was to evaluate the serum pattern of cytokines evolution after surgical radiofrequency ablation (SRFA) of colorectal metastases.


METHODS
Metastases of ten non consecutive patients were destroyed by radiofrequency ablation without concomitant resection after a complete surgical procedure including a laparotomy, a peritoneal examination, liver mobilisation and liver ultrasound. Serum levels of IL-6, TNFalpha, HGF, VEGF, bFGF, TGFbeta1 and CRP were assessed by ELISA assays at different time points.


RESULTS
TNFalpha and bFGF remained undetectable. IL-6 peaked at 3 hours and remained elevated during the entire study period. HGF increased by three-fold by Day 1 then decreased until Day 7 where it was still twice its baseline level. VEGF level increased from Day 5 onward. TGFbeta1 did not show significant variations. CRP was increased throughout the study.


CONCLUSIONS
In contrast with cryotherapy, SRFA does not lead to high serum TNFalpha suggesting a better tolerance. Nevertheless high IL-6, HGF and VEGF serum levels are characteristic of a general inflammatory stress which should be taken into account.
Evrard
Serge
S
Institut Bergonié, Digestive Tumours Unit, Bordeaux. evrard@bergonie.org
Menetrier-Caux
Christine
C
Biota
Cathy
C
Neaud
Véronique
V
Mathoulin-Pélissier
Simone
S
Blay
Jean-Yves
JY
Rosenbaum
Jean
J
D000368:Aged; D017115:Catheter Ablation; D015179:Colorectal Neoplasms / Q000473:pathology*; D016207:Cytokines / Q000097:blood*; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary / Q000601:surgery*; D008875:Middle Aged
D016207:Cytokines