T cells and B cells in lupus nephritis.
T and B lymphocytes play diverse roles at multiple stages in the development and progression of lupus nephritis. Disruption of T- and B-cell regulatory functions by environmental and genetic influences permits pathogenic effectors to emerge in disease. New insights into the biology of these multifunctional cells offer novel targets for intervention in lupus nephritis and systemic autoimmunity.
Foster
Mary H
MH
Department of Medicine, Division of Nephrology, Duke University Medical Center, Durham, NC 27710, USA. mhfoster@duke.edu
D000818:Animals; D001323:Autoantibodies / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology*; D016207:Cytokines / Q000502:physiology; D006801:Humans; D007108:Immune Tolerance; D008181:Lupus Nephritis / Q000209:etiology / Q000276:immunology* / Q000628:therapy; D013601:T-Lymphocytes / Q000276:immunology*
D001323:Autoantibodies; D016207:Cytokines