title: Further evidence for BRCA1 communication with the inactive X chromosome.
abstract: BRCA1, a breast and ovarian cancer-suppressor gene, exerts tumor-suppressing functions that appear to be associated, at least in part, with its DNA repair, checkpoint, and mitotic regulatory activities. Earlier work from our laboratory also suggested an ability of BRCA1 to communicate with the inactive X chromosome (Xi) in female somatic cells (Ganesan et al., 2002). Xiao et al. (2007) (this issue of Cell) have challenged this conclusion. Here we discuss recently published data from our laboratory and others and present new results that, together, provide further support for a role of BRCA1 in the regulation of XIST concentration on Xi in somatic cells.
authors.affiliation: Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.
authors.forename: Daniel P
authors.initials: DP
authors.lastname: Silver
authors.forename: Stoil D
authors.initials: SD
authors.lastname: Dimitrov
authors.forename: Jean
authors.initials: J
authors.lastname: Feunteun
authors.forename: Rebecca
authors.initials: R
authors.lastname: Gelman
authors.forename: Ronny
authors.initials: R
authors.lastname: Drapkin
authors.forename: Shihua D
authors.initials: SD
authors.lastname: Lu
authors.forename: Elena
authors.initials: E
authors.lastname: Shestakova
authors.forename: Soundarapandian
authors.initials: S
authors.lastname: Velmurugan
authors.forename: Nicholas
authors.initials: N
authors.lastname: Denunzio
authors.forename: Serban
authors.initials: S
authors.lastname: Dragomir
authors.forename: Jessica
authors.initials: J
authors.lastname: Mar
authors.forename: Xiaoling
authors.initials: X
authors.lastname: Liu
authors.forename: Sven
authors.initials: S
authors.lastname: Rottenberg
authors.forename: Jos
authors.initials: J
authors.lastname: Jonkers
authors.forename: Shridar
authors.initials: S
authors.lastname: Ganesan
authors.forename: David M
authors.initials: DM
authors.lastname: Livingston
mesh_terms: D000818:Animals; D019313:BRCA1 Protein / Q000235:genetics / Q000378:metabolism*; D045744:Cell Line, Tumor; D004622:Embryo, Mammalian / Q000166:cytology; D005260:Female; D005347:Fibroblasts; D019398:Genes, BRCA1; D024522:Genes, BRCA2; D008325:Mammary Neoplasms, Experimental / Q000235:genetics / Q000378:metabolism; D051379:Mice; D009154:Mutation; D034622:RNA Interference; D062085:RNA, Long Noncoding; D022661:RNA, Untranslated / Q000378:metabolism*; D014960:X Chromosome / Q000378:metabolism*; D049951:X Chromosome Inactivation
chemical_list: D019313:BRCA1 Protein; D062085:RNA, Long Noncoding; D022661:RNA, Untranslated; C077885:XIST non-coding RNA