Impairment of spatial memory consolidation in APP(751SL) mice results in cue-guided response.
APP(751SL) mice of 5-6- and 7-8-month-old and their wild-type littermates were submitted to one-session learning in a water-maze with three levels of training (4, 12 or 22 trials). Training consisted in finding a submerged platform with a fixed location and marked by a cue. During testing two platforms were presented: one consistent with the spatial location allowing place-response (PR) and the other signaled by the cue enabling cued-response (CR). When testing occurred 24h after training, wild-type and 5-6-month-old APP(751SL) mice exhibited a shift in response strategy as a function of training level, by executing CR when trained with 4 trials and PR when trained with 12 trials, but 7-8-month-old APP(751SL) mice executed only CR. However, they displayed PR when tested 1h after 12- and 22-trial, suggesting a consolidation deficit. Zif268 imaging showed plasticity impairment of the hippocampal-dependent memory system but not of the dorsolateral caudate nucleus. Moreover, in these APP(751SL) mice, the deficit selectively affecting hippocampal function cannot be directly related to the onset of beta-amyloid deposits.
Blanchard
J
J
Laboratory of Cognitive Neuroscience, CNRS UMR 5106, University of Bordeaux I, Avenue des Facultés, 33405 Talence Cedex, France.
Martel
G
G
Guillou
J-L
JL
Noguès
X
X
Micheau
J
J
D000544:Alzheimer Disease / Q000378:metabolism*; D016564:Amyloid beta-Protein Precursor / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D003463:Cues; D004195:Disease Models, Animal; D006801:Humans; D008297:Male; D011939:Mental Recall; D051379:Mice; D008822:Mice, Transgenic; D013028:Space Perception
D016564:Amyloid beta-Protein Precursor