Increased BRCA1 protein in mammary tumours of rats fed marine omega-3 fatty acids.
Any factor affecting BRCA gene regulation may be of interest in the prevention of breast tumourigenesis. We studied the influence of dietary docosahexaenoic acid (DHA), a major omega-3 fatty acid present in marine products, on rat autochthonous mammary tumourigenesis. DHA-supplementation significantly reduced the incidence of tumours (30%, P=0.007) and led to a 60% increase (P=0.02) in BRCA1 protein level. Since DHA influences the product of a major tumour suppressor gene, this finding may contribute to the observation that high-fish consumption reduces the risk of breast cancer.
Jourdan
Marie-Lise
ML
INSERM, E 0211; Université François Rabelais; CHU Bretonneau, Tours, F-37000, France.
Mahéo
Karine
K
Barascu
Aurélia
A
Goupille
Caroline
C
De Latour
Monique Peffault
MP
Bougnoux
Philippe
P
Rio
Pascale G
PG
D000818:Animals; D019313:BRCA1 Protein / Q000032:analysis / Q000235:genetics / Q000378:metabolism*; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage*; D004281:Docosahexaenoic Acids / Q000008:administration & dosage*; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage*; D005260:Female; D015674:Mammary Neoplasms, Animal / Q000737:chemistry / Q000378:metabolism* / Q000517:prevention & control*; D012333:RNA, Messenger / Q000032:analysis / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D015854:Up-Regulation
D019313:BRCA1 Protein; D004042:Dietary Fats, Unsaturated; D015525:Fatty Acids, Omega-3; D012333:RNA, Messenger; D004281:Docosahexaenoic Acids