title: [Giant prostate carcinoma treated effectively with endocrine therapy: case report].
abstract: An 87-year-old man visited our hospital, complaining of abdominal distention and inability to urinate. Computed tomography (CT) and magnetic resonance imaging revealed a giant prostate tumor. The patient underwent percutaneous tumor biopsies. The histologic diagnosis was moderately differentiated adenocarcinoma of prostate. The clinical stage according to the TNM classification system was T4N0M0, stage IV. Combined androgen blockade therapy was performed. Four months later, CT showed that the tumor had decreased markedly in size, and the serum prostate specific antigen level was within normal range. Hormone refractory prostate cancer was not found 1 year after the start of treatment.
authors.affiliation: The Department of Urology, Matsunami General Hospital.
authors.forename: Naruyasu
authors.initials: N
authors.lastname: Masue
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Hasegawa
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology; D000317:Adrenergic alpha-Antagonists / Q000008:administration & dosage; D000369:Aged, 80 and over; D000726:Androgen Antagonists / Q000627:therapeutic use*; D000813:Anilides / Q000627:therapeutic use; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use*; D002715:Chlormadinone Acetate / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D017273:Goserelin / Q000627:therapeutic use*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009281:Naphthalenes / Q000008:administration & dosage; D009570:Nitriles; D010879:Piperazines / Q000008:administration & dosage; D017430:Prostate-Specific Antigen / Q000097:blood; D011471:Prostatic Neoplasms / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology; D014105:Tosyl Compounds / Q000627:therapeutic use
chemical_list: D000317:Adrenergic alpha-Antagonists; D000726:Androgen Antagonists; D000813:Anilides; D018931:Antineoplastic Agents, Hormonal; D009281:Naphthalenes; D009570:Nitriles; D010879:Piperazines; D014105:Tosyl Compounds; D017273:Goserelin; D002715:Chlormadinone Acetate; C053541:bicalutamide; D017430:Prostate-Specific Antigen; C064357:naftopidil