title: Estrogen receptor beta gene +1730 G/A polymorphism in women with endometriosis.
abstract: OBJECTIVE
  To investigate whether the +1730 G/A polymorphism of the estrogen receptor beta (ER-beta) gene is associated with the risk of endometriosis in a Korean population.
  
  
  METHODS
  Case-control study.
  
  
  METHODS
  University Department of Obstetrics and Gynecology.
  
  
  METHODS
  Women with (n = 239) or without (n = 287) endometriosis.
  
  
  METHODS
  The +1730 G/A polymorphism of 3'-UTR of exon 8 in the ER-beta gene was assessed by polymerase chain reaction-restriction fragment-length polymorphism analysis utilizing digestion with AluI restriction enzyme.
  
  
  METHODS
  Genotype distribution and allele frequency of the +1730 G/A polymorphism in the ER-beta gene.
  
  
  RESULTS
  The genotype distribution of the +1730 G/A polymorphism in the ER-beta gene was not different between the endometriosis patients and the controls (G/G of 74.9% vs. 72.5%, G/A of 25.1% vs. 26.1%, and A/A of 0.0% vs. 1.4%, respectively). There was also no difference in the G and A allele frequencies between the two groups (87.4% vs. 85.5%, and 12.6% vs. 14.5%, respectively). Even when the endometriosis cases were subdivided into American Society for Reproductive Medicine stage I-II, III, IV, and III-IV, no differences were found at all in the genotype distribution or allele frequencies between the two groups.
  
  
  CONCLUSIONS
  Our results suggest that the +1730 G/A polymorphism of the ER-beta gene may not be associated with the risk of endometriosis in the Korean population, which was not the case in the Japanese population.
authors.affiliation: Department of Obstetrics and Gynecology, Medical Research Center, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Gyoung Hoon
authors.initials: GH
authors.lastname: Lee
authors.forename: Sung Hoon
authors.initials: SH
authors.lastname: Kim
authors.forename: Young Min
authors.initials: YM
authors.lastname: Choi
authors.forename: Chang Suk
authors.initials: CS
authors.lastname: Suh
authors.forename: Jung Gu
authors.initials: JG
authors.lastname: Kim
authors.forename: Shin Yong
authors.initials: SY
authors.lastname: Moon
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D004715:Endometriosis / Q000453:epidemiology / Q000235:genetics*; D047629:Estrogen Receptor beta / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D006801:Humans; D007723:Korea / Q000453:epidemiology; D011110:Polymorphism, Genetic
chemical_list: D047629:Estrogen Receptor beta