p38 MAPK in regulating cellular responses to ultraviolet radiation.
Solar ultraviolet (UV) radiation is a major environmental factor that causes DNA damage, inflammation, erythema, sunburn, immunosuppression, photoaging, gene mutations, and skin cancer. p38 mitogen activated protein kinase (MAPK) are strongly activated by UV radiation, and play important roles in regulating cellular responses to UV. In this review, we examine the role played by p38 MAPK in mediating UV-induced cell cycle, apoptosis, inflammation, and skin tanning response. We review the role played by p38 MAPK in transcriptional regulation of key downstream genes that have been implicated in the regulation of cellular responses to UV radiation. Understanding this will undoubtedly help in the prevention and control of UV-induced damage and the development of novel therapeutic strategies.
Jinlian
Li
L
Medical College, Qingdao University, 422 Room, Boya Building, 308 Ningxia Road, Qingdao, 266071, China. ljl813@sina.com
Yingbin
Zhou
Z
Chunbo
Wang
W
D017209:Apoptosis / Q000235:genetics / Q000502:physiology / Q000528:radiation effects*; D002453:Cell Cycle / Q000235:genetics / Q000502:physiology / Q000528:radiation effects; D002478:Cells, Cultured; D005786:Gene Expression Regulation; D006801:Humans; D014466:Ultraviolet Rays; D048051:p38 Mitogen-Activated Protein Kinases / Q000502:physiology*
D048051:p38 Mitogen-Activated Protein Kinases