Transcription and coregulation of multigene families in Plasmodium falciparum.
Subtelomeric regions in the Plasmodium genome are enriched with members of three major multigene families: var, rif and stevor. In this article, we discuss a recent study by Sharp and colleagues that focused on the transcribed repertoire of var and stevor genes in asexual and sexual Plasmodium parasites. Transcription of these two multigene families seems to be unlinked in asexual parasites. Parasites in the gametocyte stages transcribe members of the upsC subset of var genes, which indicates the intriguing possibility of their involvement in gametocyte adhesion.
Duffy
Michael F
MF
Department of Medicine, Royal Melbourne Hospital, University of Melbourne, Parkville, VIC 3050, Australia. mduffy@unimelb.edu.au
Tham
Wai-Hong
WH
D000818:Animals; D000940:Antigenic Variation; D000953:Antigens, Protozoan; D005718:Gametogenesis; D018507:Gene Expression Regulation, Developmental; D018503:Genome, Protozoan; D008018:Life Cycle Stages / Q000235:genetics*; D010963:Plasmodium falciparum / Q000235:genetics*; D015800:Protozoan Proteins; D014158:Transcription, Genetic
D000953:Antigens, Protozoan; D015800:Protozoan Proteins; C474556:STEVOR antigen, Plasmodium falciparum; C085731:erythrocyte membrane protein 1, Plasmodium falciparum