title: Acute abdomen as initial manifestation of M4 - acute non-lymphocytic leukemia.
abstract: Visceral involvement in acute non-lymphocytic leukemia (ANLL) seldom precedes hematological manifestation. We report on a patient with M4 - ANLL presenting with acute abdomen without any evidence of blood disorder. Laparotomy revealed only ileal wall oedema. Postoperative clinical deterioration led to a second-look operation combined with intraoperative endoscopy. Biopsied tissues were diffusely infiltrated by blasts characterised as HLA-DR (+), PGM1 (50% +), MPO (50% +) and CD 34 (-). Bone marrow reconfirmed these findings and showed positivity for CD4 (44%), CD11b (50%), CD11c (42%), CD13 (33%), CD34 (32%), and CD56 (54%). Chemotherapy achieved a complete but short remission. Relapse occurred 7 months later. Immediately after consolidation chemotherapy the profoundly immunosuppressed patient passed away after a lower respiratory tract infection. We discuss the contrast between histology and short disease duration, the unusual presentation and the bad prognosis, and attempt to correlate the clinical course with the coexpression of markers.
authors.affiliation: First Department of Surgery, "Laikon" General University Hospital, University of Athens, Medical School, Athens, Greece.
authors.forename: E
authors.initials: E
authors.lastname: Papalambros
authors.forename: E
authors.initials: E
authors.lastname: Felekouras
authors.forename: I G
authors.initials: IG
authors.lastname: Karavokyros
authors.forename: T
authors.initials: T
authors.lastname: Diamantis
authors.forename: A
authors.initials: A
authors.lastname: Androulaki
authors.forename: D
authors.initials: D
authors.lastname: Boutsis
authors.forename: F
authors.initials: F
authors.lastname: Sigala
authors.forename: N
authors.initials: N
authors.lastname: Tsavaris
authors.forename: G
authors.initials: G
authors.lastname: Pangalis