Study of expression and functional activity of P-GP membrane glycoprotein in children with acute leukemia.
We studied expression and functional activity of tumor cell P-gp in children with various leukemia variants and analyzed its prognostic role in acute lymphoblastic leukemia. Functional activity of P-gp increased in acute myeloid leukemia, relapses of acute lymphoblastic leukemia (in comparison with primary disease), and in a group of patients in whom no remission was attained. The survival of patients with acute lymphoblastic leukemia was lower in cases with increased expression and function of P-gp.
Shman
T V
TV
Republican Center of Children Oncology and Hematology, Minsk.
Savitskii
V P
VP
Potapnev
M P
MP
Aleinikova
O V
OV
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000378:metabolism*; D000293:Adolescent; D000911:Antibodies, Monoclonal; D001562:Benzimidazoles; D002232:Carbocyanines; D002648:Child; D002675:Child, Preschool; D005434:Flow Cytometry; D015870:Gene Expression; D006801:Humans; D007223:Infant; D015470:Leukemia, Myeloid, Acute / Q000378:metabolism*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000378:metabolism*; D011379:Prognosis; D018709:Statistics, Nonparametric; D016019:Survival Analysis
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D000911:Antibodies, Monoclonal; D001562:Benzimidazoles; D002232:Carbocyanines; C068624:5,5',6,6'-tetrachloro-1,1',3,3'-tetraethylbenzimidazolocarbocyanine