Alkaloids from Melochia chamaedrys.
Investigation of the chemical constituents from the roots of Melochia chamaedrys (Sterculiaceae) resulted in the isolation of two quinolinone alkaloids: a new alkaloid, named chamaedrone (1), and a known alkaloid, antidesmone (2). Their structures and stereochemistry were elucidated on the basis of 2D NMR and X-ray crystallographic analysis. Furthermore, alkaloids 1 and 2, and the synthetic analogues 3-6 obtained from 2, were screened for antimicrobial activities.
Dias
Gilvan O C
GO
Departamento de Química, NPPN, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil.
Porto
Carla
C
Stüker
Caroline Z
CZ
Graessler
Vanessa
V
Burrow
Robert A
RA
Dalcol
Ionara I
II
da Silva
Ubiratan F
UF
Morel
Ademir F
AF
D000470:Alkaloids / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D002176:Candida albicans / Q000187:drug effects; D018360:Crystallography, X-Ray; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D019660:Malvaceae; D008826:Microbial Sensitivity Tests; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D018517:Plant Roots; D012441:Saccharomyces cerevisiae / Q000187:drug effects
D000470:Alkaloids; D000890:Anti-Infective Agents; D010936:Plant Extracts