[Encephalopathy in the rat following partial portosystemic anastomosis].
Gamma-aminobutyric acid (GABA) values were determined in 4 groups of Sprague-Dawley rats 45-50 days after end-to-side porto-cava (PC), mesentericosplenic-cava (MSC) and mesenteric-cava (MC) anastomosis, and a false operation (FO) respectively. Values were significantly increased in the anastomosed animals. If, as may be supposed, this finding points to altered cerebral metabolism, its observation in the MSC and MC groups militates against the general view that encephalopathy in the experimental animal only occurs as a result of total deviation of the portal flow.
Stella
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GD
Istituto di Patologia Speciale Chirurgica e Propedeutica Clinica dell'Università di Pavia.
Vassanelli
P
P
Gonzato
P
P
Rizzi
B
B
Pelizzo
M R
MR
D000818:Animals; D001923:Brain Chemistry; D004195:Disease Models, Animal; D006501:Hepatic Encephalopathy / Q000209:etiology* / Q000378:metabolism; D008297:Male; D008642:Mesenteric Veins / Q000601:surgery; D011169:Portal Vein / Q000601:surgery; D011170:Portasystemic Shunt, Surgical / Q000009:adverse effects* / Q000379:methods; D011183:Postoperative Complications / Q000209:etiology* / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D013162:Splenic Vein / Q000601:surgery; D014682:Vena Cava, Inferior / Q000601:surgery; D005680:gamma-Aminobutyric Acid / Q000032:analysis
D005680:gamma-Aminobutyric Acid