Non-genetic expression of adolescent idiopathic scoliosis: a case report and review of the literature.
Treating children with idiopathic scoliosis can amaze someone at the many different ways in which the deformity can present. Most authors state that genetics stipulates the course of adolescent idiopathic scoliosis. This is mainly based on the high concordance in monozygotic twins. However, there is indication that environmental factors have influences on adolescent idiopathic scoliosis. This is the first report in which a monozygotic twin pair is described concordant for idiopathic scoliosis but with different apical levels, magnitudes and age at detection of scoliosis which stresses the importance of environmental factors.
Hermus
Joris P S
JP
Department of Orthopaedic Surgery, University Hospital Maastricht, P.O. Box 5800, 6202 AZ Maastricht, The Netherlands. jhermu@sort.azm.nl
van Rhijn
Lodewijk W
LW
van Ooij
André
A
D000293:Adolescent; D000367:Age Factors; D017668:Age of Onset; D000375:Aging / Q000235:genetics; D002648:Child; D016172:DNA Fingerprinting; D018450:Disease Progression; D004777:Environment; D044127:Epigenesis, Genetic / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D008297:Male; D010641:Phenotype; D011859:Radiography; D012600:Scoliosis / Q000209:etiology* / Q000235:genetics / Q000473:pathology; D013131:Spine / Q000000981:diagnostic imaging / Q000473:pathology* / Q000503:physiopathology; D013904:Thoracic Vertebrae / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology; D014430:Twins, Monozygotic / Q000235:genetics*