title: The first asymmetric total syntheses and determination of absolute configurations of xestodecalactones B and C.
abstract: The first efficient asymmetric total syntheses of xestodecalactones B and C have been accomplished in 10 steps with an overall yield of 22 and 20.2%, respectively. The key steps involve the utility of Evans oxazolidinone-mediated syn-aldol condensations to establish the C-9 configuration and the macrolide ring formation by intramolecular acylation. The absolute configurations of xestodecalactones B and C have been determined via these syntheses.
authors.affiliation: Department of Chemistry, State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, P.R. China.
authors.forename: Qiren
authors.initials: Q
authors.lastname: Liang
authors.forename: Jiyong
authors.initials: J
authors.lastname: Zhang
authors.forename: Weiguo
authors.initials: W
authors.lastname: Quan
authors.forename: Yongquan
authors.initials: Y
authors.lastname: Sun
authors.forename: Xuegong
authors.initials: X
authors.lastname: She
authors.forename: Xinfu
authors.initials: X
authors.lastname: Pan
mesh_terms: D007783:Lactones / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D007783:Lactones; C471497:xestodecalactone B; C471498:xestodecalactone C