The path to insulin resistance: paved with ceramides?
Obesity-associated, system-wide elevations in free fatty acids, tumor necrosis factor alpha, and glucocorticoids increase intracellular lipid metabolites and promote insulin resistance. In this issue, Holland et al. (2007) provide pharmacological and genetic evidence that ceramide plays a key role in the development of insulin resistance induced by these factors.
Zierath
Juleen R
JR
Department of Molecular Medicine and Surgery, Section of Integrative Physiology, Karolinska Institutet, von Eulers väg 4, S-171 77 Stockholm, Sweden. juleen.zierath@ki.se
D000818:Animals; D002518:Ceramides / Q000378:metabolism*; D006801:Humans; D007333:Insulin Resistance; D050356:Lipid Metabolism; D051379:Mice; D009765:Obesity / Q000378:metabolism
D002518:Ceramides