title: [Effects of new nitric oxide synthase inhibitors on spontaneous locomotor activity].
abstract: BACKGROUND
  New nitric oxide synthase (NOS) inhibitors: 3-bromo-7-nitroindazole (3-Br-7-NI), 1-(2-trifluoromethylphenyl) imidazole (TRIM), S-methyl-L-thiocitrulline (S-Me-TC) and 7-nitroindazole (7-NI) reduce spontaneous locomotor activity in mice.
  
  
  METHODS
  In order to elucidate central effects of NOS inhibitors on locomotor activity, the influence of 7-NI on electroencephalographic (EEG) power spectrum in rats was investigated.
  
  
  RESULTS
  7-NI reduced the EEG power density in all frequency bands in rats, suggesting a depression of the central neuronal activity. The electrophysiologic power was most reduced in the range of 7-9 Hz of the rhythmic slow activity (theta rhythm), which is in accordance with decreased locomotor activity observed following administration of NOS inhibitors.
  
  
  CONCLUSIONS
  The present results indicate that nitric oxide exerts an excitatory effect on central neuronal structures involved in regulation of locomotion.
authors.affiliation: Klinicki centar Srbije, Beograd, Institut za neurologiju, Medicinski fakultet, Beograd.
authors.forename: Eleonora
authors.initials: E
authors.lastname: Dzoljić
authors.forename: Zorica
authors.initials: Z
authors.lastname: Nesić
authors.forename: Radan
authors.initials: R
authors.lastname: Stojanović
authors.forename: Sonja
authors.initials: S
authors.lastname: Vucković
authors.forename: Zoran
authors.initials: Z
authors.lastname: Todorović
authors.forename: Milica
authors.initials: M
authors.lastname: Prostran
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D004569:Electroencephalography; D051379:Mice; D009043:Motor Activity / Q000187:drug effects*; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors* / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar
chemical_list: D019001:Nitric Oxide Synthase