title: Giant hypertrophic gastritis (Menetrier's-like disease) in an Old English sheepdog.
abstract: An 11-year-old, male Old English sheepdog was admitted for weight loss and intermittent vomiting of 1 month's duration. A cranioventral abdominal mass, anemia, hypoproteinemia, and hypoalbuminemia were the prominent abnormal findings. Imaging studies identified a remarkably thickened gastric wall with multilobulated folds protruding into the gastric lumen. Gastrotomy revealed the presence of giant cerebriform rugal folds arising from the fundus and body of the stomach. Pronounced gastric glandular hyperplasia and lack of evidence of cellular atypia were suggestive of giant hypertrophic gastritis. The dog was treated with prednisolone, cimetidine, and hyoscine butylbromide, only to experience a short-term remission.
authors.affiliation: Clinic of Companion Animal Medicine, School of Veterinary Medicine, Aristotle University of Thessaloniki, 11, St Voutyra str, 54627 Thessaloniki, Greece.
authors.forename: Tim S
authors.initials: TS
authors.lastname: Rallis
authors.forename: Michael N
authors.initials: MN
authors.lastname: Patsikas
authors.forename: Mathios E
authors.initials: ME
authors.lastname: Mylonakis
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Day
authors.forename: Theodoros A
authors.initials: TA
authors.lastname: Petanides
authors.forename: Lysimachos G
authors.initials: LG
authors.lastname: Papazoglou
authors.forename: Alexander F
authors.initials: AF
authors.lastname: Koutinas
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage; D000897:Anti-Ulcer Agents / Q000008:administration & dosage; D000932:Antiemetics / Q000008:administration & dosage; D002086:Butylscopolammonium Bromide / Q000008:administration & dosage; D002927:Cimetidine / Q000008:administration & dosage; D000077324:Crystalloid Solutions; D004283:Dog Diseases / Q000175:diagnosis* / Q000188:drug therapy* / Q000473:pathology; D004285:Dogs; D005753:Gastric Mucosa / Q000473:pathology; D005758:Gastritis, Hypertrophic / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D006965:Hyperplasia / Q000662:veterinary; D007552:Isotonic Solutions / Q000008:administration & dosage; D008297:Male; D008787:Metoclopramide / Q000008:administration & dosage; D018727:Muscarinic Antagonists / Q000008:administration & dosage; D011239:Prednisolone / Q000008:administration & dosage; D016896:Treatment Outcome
chemical_list: D000893:Anti-Inflammatory Agents; D000897:Anti-Ulcer Agents; D000932:Antiemetics; D000077324:Crystalloid Solutions; D007552:Isotonic Solutions; D018727:Muscarinic Antagonists; D002086:Butylscopolammonium Bromide; D002927:Cimetidine; D011239:Prednisolone; D008787:Metoclopramide