Hu and Yo antibodies have heterogeneous avidity.
Onconeural antibodies such as anti-Hu and anti-Yo may be important in the pathogenesis of paraneoplastic neurological syndromes. The avidity of these antibodies is not known. In this study, we compared the avidity of Hu and Yo antibodies both at single time points and over a time range of 2 months to 6 years. The avidity of Yo and Hu antibodies differed among the patients, but anti-Yo generally had higher avidity than anti-Hu. Whether Yo antibodies are more pathogenic than Hu antibodies are presently unknown.
Totland
Cecilie
C
Department of Neurology, Haukeland University Hospital, Norway; Department of Clinical Medicine, University of Bergen, Norway.
Aarseth
Jan
J
Vedeler
Christian
C
D000818:Animals; D000912:Antibodies, Neoplasm / Q000097:blood / Q000276:immunology*; D000915:Antibody Affinity; D051959:ELAV Proteins / Q000097:blood / Q000276:immunology*; D019084:Fluorescent Antibody Technique, Indirect; D006801:Humans; D047468:Immunoprecipitation; D009419:Nerve Tissue Proteins / Q000097:blood / Q000276:immunology*; D010257:Paraneoplastic Syndromes / Q000097:blood / Q000276:immunology*; D051381:Rats
D000912:Antibodies, Neoplasm; C095184:CDR2 protein, human; D051959:ELAV Proteins; D009419:Nerve Tissue Proteins