Structure and function of the NS1 protein of influenza A virus.
The avian influenza A virus currently prevailing in Asia causes fatal pneumonia and multiple organ failure in birds and humans. Despite intensive research, understanding of the characteristics of influenza A virus that determine its virulence is incomplete. NS1A protein, a non-structural protein of influenza A virus, was reported to contribute to its pathogenicity and virulence. NS1A protein is a multifunctional protein that plays a significant role in resisting the host antiviral response during the influenza infection. This review briefly outlines the current knowledge on the structure and function of the NS1A protein.
Lin
Dongzi
D
Department of Biochemistry and Molecular Biology, Guangdong Medical College, Zhanjiang, China.
Lan
Jingfang
J
Zhang
Zhizhen
Z
D000818:Animals; D001665:Binding Sites; D055592:Biophysical Phenomena; D001703:Biophysics; D001717:Birds; D019281:Dimerization; D006801:Humans; D009980:Influenza A virus / Q000737:chemistry* / Q000472:pathogenicity / Q000502:physiology*; D005585:Influenza in Birds / Q000821:virology; D007251:Influenza, Human / Q000821:virology; D008954:Models, Biological; D008958:Models, Molecular; D011487:Protein Conformation; D020836:Protein Structure, Quaternary; D017361:Viral Nonstructural Proteins / Q000737:chemistry* / Q000502:physiology*; D014779:Virus Replication
C085820:INS1 protein, influenza virus; D017361:Viral Nonstructural Proteins