Histoplasmosis-associated cross-reactivity in the BioRad Platelia Aspergillus enzyme immunoassay.
We observed false-positive results in the Platelia Aspergillus enzyme-linked immunoassay (EIA) for specimens from patients with histoplasmosis and mice with experimental infection. Platelia Aspergillus EIA-positive specimens were negative in the second-generation Histoplasma antigen EIA. Care must be taken to exclude histoplasmosis for patients with positive Platelia Aspergillus EIA results.
Wheat
L Joseph
LJ
MiraVista Diagnostics, 4444 Decatur Blvd., Suite 300, Indianapolis, IN 46241, USA. jwheat@miravistalabs.com
Hackett
Emily
E
Durkin
Michelle
M
Connolly
Patricia
P
Petraitiene
Ruta
R
Walsh
Thomas J
TJ
Knox
Kenneth
K
Hage
Chadi
C
D000818:Animals; D000908:Antibodies, Fungal; D000946:Antigens, Fungal / Q000097:blood*; D001229:Aspergillosis, Allergic Bronchopulmonary / Q000175:diagnosis; D003429:Cross Reactions; D004195:Disease Models, Animal; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods*; D005690:Galactose / Q000031:analogs & derivatives; D006660:Histoplasmosis / Q000097:blood* / Q000276:immunology*; D006801:Humans; D008351:Mannans / Q000276:immunology; D051379:Mice; D011817:Rabbits
D000908:Antibodies, Fungal; D000946:Antigens, Fungal; D008351:Mannans; C012990:galactomannan; D005690:Galactose