title: A novel robotic laser ablation system for precision neurosurgery with intraoperative 5-ALA-induced PpIX fluorescence detection.
abstract: We developed a combined system of tumor detection by 5-ALA-induced PpIX fluorescence and precise ablation by micro laser for the first time, with an automatic focusing and robotic scanning mechanism for the brain surface. 5-ALA accumulates on tumors to be metabolized to become PpIX that is a fluorescent. Intra-operative detection of 5-ALA induced PpIX fluorescence provides useful information for tumor detection. The wavelength of the micro laser is 2.8 microm close to the absorption band of water. This laser is effective only on the surface of brain tissue, enabling precise ablation at the boundary between tumor and normal tissue identified by intra-operative 5-ALA induced fluorescence. Combination tests of the fluorescence measurement and the laser ablation were performed, and it was possible to extract the area with fluorescence appropriately from the measurement data, and the micro laser with automatically scanning selectively ablated the extracted area.
authors.affiliation: Graduate School of Frontier Sciences, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-8656, Japan. masamasa@miki.pe.u-tokyo.ac.jp
authors.forename: Masafumi
authors.initials: M
authors.lastname: Noguchi
authors.forename: Eisuke
authors.initials: E
authors.lastname: Aoki
authors.forename: Daiki
authors.initials: D
authors.lastname: Yoshida
authors.forename: Etsuko
authors.initials: E
authors.lastname: Kobayashi
authors.forename: Shigeru
authors.initials: S
authors.lastname: Omori
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Muragaki
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Iseki
authors.forename: Katsushige
authors.initials: K
authors.lastname: Nakamura
authors.forename: Ichiro
authors.initials: I
authors.lastname: Sakuma
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000473:pathology* / Q000601:surgery*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D053685:Laser Therapy / Q000295:instrumentation* / Q000379:methods; D008856:Microscopy, Fluorescence / Q000295:instrumentation* / Q000379:methods; D016343:Monitoring, Intraoperative / Q000295:instrumentation / Q000379:methods; D019635:Neurosurgical Procedures / Q000295:instrumentation* / Q000379:methods; D011524:Protoporphyrins; D012371:Robotics / Q000295:instrumentation* / Q000379:methods; D025321:Surgery, Computer-Assisted / Q000295:instrumentation* / Q000379:methods; D013552:Swine
chemical_list: D011524:Protoporphyrins; C028025:protoporphyrin IX