title: HHV-8 positive Kaposi sarcoma in a patient with end-stage renal disease undergoing hemodialysis: no regressive effect of captopril.
abstract: Human herpesvirus 8 (HHV-8) has been associated with Kaposi sarcoma (KS) in renal transplant recipients. On the other hand, there are only a few reported cases of KS in patients with end stage renal failure receiving hemodialysis. Here, we report a case of HHV-8 positive, disseminated KS, in a 70-year-old man with renal failure, receiving hemodialysis for 7 months. The KS lesions had begun to develop almost at the same time with the onset of dialysis. The patient had been on captopril therapy since the diagnosis of renal failure. Captopril has been reported to inhibit angiogenesis, and by this way, to reduce tumor growth. However, in our patient, the lesions had developed under the treatment of captopril, and showed no evidence of regression after withdrawal of the drug.
authors.affiliation: Haydarpaşa Numune Training and Research Hospital Department of Dermatology, 34668 Istanbul, Turkey.
authors.forename: Sirin
authors.initials: S
authors.lastname: Yaşar
authors.forename: Ayse Tülin
authors.initials: AT
authors.lastname: Mansur
authors.forename: Fatih
authors.initials: F
authors.lastname: Göktay
authors.forename: Ikbal Esen
authors.initials: IE
authors.lastname: Aydingöz
mesh_terms: D000368:Aged; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D002216:Captopril / Q000627:therapeutic use; D003937:Diagnosis, Differential; D019288:Herpesvirus 8, Human; D006801:Humans; D007676:Kidney Failure, Chronic / Q000188:drug therapy / Q000628:therapy*; D008297:Male; D006435:Renal Dialysis; D012514:Sarcoma, Kaposi / Q000175:diagnosis* / Q000473:pathology / Q000821:virology; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000821:virology; D017211:Treatment Failure
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D002216:Captopril