title: Nestin, a maker for multilineage potential of cells from human primary and restenotic coronary artery plaques.
abstract: Nestin is a type of intermediate filament abundantly expressed in neuroepithelial stem cells or mesenchymal stem cells. We assessed directional coronary atherectomy specimens from primary and restenotic lesions for expression of nestin. Immunohistochemistry showed predominant expression of nestin in stellate smooth muscle cells (SMCs). Given that nestin has been proposed to be a marker for putative stem cells, our results suggest that human coronary plaques contain cells that have the potential for multiple lineages. Although the role of nestin remains unclear, nestin-positive stellate SMCs are more frequently seen in patients with unstable angina.
authors.affiliation: Department of Medicine and Biological Science, Gunma University Graduate School of Medicine, Showa-machi, Maebashi, Gunma, Japan. sugutam@showa.gunma-u.ac.jp <sugutam@showa.gunma-u.ac.jp>
authors.forename: Masahiko
authors.initials: M
authors.lastname: Suguta
authors.forename: Akihiko
authors.initials: A
authors.lastname: Nakano
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Hoshino
authors.forename: Michiko
authors.initials: M
authors.lastname: Endoh
authors.forename: Takashi
authors.initials: T
authors.lastname: Hatori
authors.forename: Akira
authors.initials: A
authors.lastname: Hasegawa
authors.forename: Masanori
authors.initials: M
authors.lastname: Aihara
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Takeuchi
authors.forename: Masahiko
authors.initials: M
authors.lastname: Kurabayashi
mesh_terms: D000368:Aged; D017225:Atherectomy, Coronary; D003324:Coronary Artery Disease / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D023903:Coronary Restenosis / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D003331:Coronary Vessels / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D018960:Hyaluronan Receptors / Q000378:metabolism; D007150:Immunohistochemistry; D007381:Intermediate Filament Proteins / Q000378:metabolism*; D008297:Male; D032389:Myocytes, Smooth Muscle / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D064231:Nestin
chemical_list: D018960:Hyaluronan Receptors; D007381:Intermediate Filament Proteins; C577484:NES protein, human; D009419:Nerve Tissue Proteins; D064231:Nestin