title: Cerebral venous sinus thrombosis associated with essential thrombocytosis in a pediatric patient.
abstract: Essential thrombocytosis (ET) is an uncommon pediatric hematologic disorder that can result in thrombotic complications, including cerebral venous sinus thrombosis (CVST). Although CVST associated with ET is exceedingly rare, it can be devastating to the patient. We here report a pediatric case of CVST associated with ET. The patient was treated with hydroxyurea and warfarin, which was later replaced by low-dose aspirin. Platelet counts were well controlled after 16 months of follow-up, and no further thrombotic events occurred. Mucositis was the main adverse effect of treatment.
authors.affiliation: Department of Radiation Oncology, Mayo Clinic, Mayo Clinic College of Medicine, Rochester, MN 55905, USA.
authors.forename: Ashley W
authors.initials: AW
authors.lastname: Jensen
authors.forename: Ayalew
authors.initials: A
authors.lastname: Tefferi
authors.forename: Carola A S
authors.initials: CA
authors.lastname: Arndt
mesh_terms: D000293:Adolescent; D000925:Anticoagulants / Q000009:adverse effects / Q000627:therapeutic use; D001241:Aspirin / Q000627:therapeutic use; D001853:Bone Marrow / Q000473:pathology; D005500:Follow-Up Studies; D006801:Humans; D006918:Hydroxyurea / Q000009:adverse effects / Q000627:therapeutic use; D018810:Magnetic Resonance Angiography / Q000379:methods; D008297:Male; D052016:Mucositis / Q000139:chemically induced; D010976:Platelet Count; D012680:Sensitivity and Specificity; D012851:Sinus Thrombosis, Intracranial / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D013922:Thrombocytosis / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D016896:Treatment Outcome; D014859:Warfarin / Q000627:therapeutic use
chemical_list: D000925:Anticoagulants; D014859:Warfarin; D001241:Aspirin; D006918:Hydroxyurea