Cloning and heterologous expression of the aranciamycin biosynthetic gene cluster revealed a new flexible glycosyltransferase.
Luzhetskyy
Andriy
A
Albert-Lüdwigs Universität, Institüt für Pharmazeutische Wissenschaften, Stefan-Meier-Strasse 19, 79104, Freibrug, Germany.
Mayer
Almuth
A
Hoffmann
Jens
J
Pelzer
Stefan
S
Holzenkämper
Meike
M
Schmitt
Bettina
B
Wohlert
Sven-Eric
SE
Vente
Andreas
A
Bechthold
Andreas
A
D018943:Anthracyclines / Q000378:metabolism* / Q000494:pharmacology; D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects; D003001:Cloning, Molecular; D004269:DNA, Bacterial / Q000235:genetics; D016695:Glycosyltransferases / Q000096:biosynthesis* / Q000235:genetics*; D008969:Molecular Sequence Data; D005810:Multigene Family; D010957:Plasmids / Q000235:genetics; D011480:Protease Inhibitors / Q000494:pharmacology; D013302:Streptomyces / Q000201:enzymology / Q000235:genetics
D018943:Anthracyclines; D004269:DNA, Bacterial; D011480:Protease Inhibitors; C075925:aranciamycin; D016695:Glycosyltransferases