Synthesis and characterization of highly-magnetic biodegradable poly(d,l-lactide-co-glycolide) nanospheres.
The objective of this study was to develop high magnetization, biodegradable/biocompatible polymer-coated magnetic nanospheres for biomedical applications. Magnetic spheres were prepared by a modified single oil-in-water emulsion-solvent evaporation method utilizing highly-concentrated hydrophobic magnetite and poly(d,l lactide-co-glycolide) (PLGA). Hydrophobic magnetite prepared using oleic acid exhibited high magnetite concentrations (84 wt.%) and good miscibility with biopolymer solvents to form a stable oily suspension. The oily suspension was then emulsified within an aqueous solution containing poly(vinyl alcohol). After rapid evaporation of the organic solvent, we obtained solid magnetic nanospheres. We characterized these spheres in terms of external morphology, microstructure, size and zeta potential, magnetite content and distribution within the nanospheres, and magnetic properties. The results showed good encapsulation where the magnetite distorted the smooth surface morphology only at the highest magnetite concentrations. The mean diameter was 360-370 nm with polydispersity indices of 0.12-0.20. We obtained high magnetite content (40-60%) and high magnetization (26-40 emu/g). The high magnetization properties were obtained while leaving sufficient polymer to retain drugs making these biodegradable spheres suitable as a potential platform for the design of magnetically-guided drug delivery and other in vivo biomagnetic applications.
Liu
Xianqiao
X
Departments of Neurology and Surgery (Neurosurgery), The University of Chicago and Pritzker School of Medicine, Chicago, IL 60637, USA.
Kaminski
Michael D
MD
Chen
Haitao
H
Torno
Michael
M
Taylor
LaToyia
L
Rosengart
Axel J
AJ
D001682:Biological Availability; D019344:Lactic Acid / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D008280:Magnetics; D043942:Nanotubes / Q000737:chemistry*; D011100:Polyglycolic Acid / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011108:Polymers / Q000138:chemical synthesis* / Q000493:pharmacokinetics
D011108:Polymers; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid