title: Portal hypertension and granulomatous liver disease in a lung transplant recipient due to disseminated atypical mycobacterial infection.
abstract: The incidence of atypical mycobacterial infection among solid organ transplant recipients is increasing. While lung transplant recipients in particular are at greater risk of atypical mycobacterial infection than other solid organ transplant recipients, it is typically confined to the lung and disseminated infection remains quite rare. We describe a case of disseminated Mycobacterium avium-complex (MAC) in a lung transplant recipient presenting as granulomatous liver disease with signs of portal hypertension. After identification of the infection and institution of proper therapy, the patient had significant improvement in both clinical signs of portal hypertension and liver function tests. Current literature suggests a favorable prognosis in most cases of MAC infection in lung transplant recipients with appropriate treatment. This case highlights the need to maintain an elevated index of suspicion for atypical pathogens with unusual clinical presentations among the lung transplant population.
authors.affiliation: Department of Medicine, Duke University Medical Center, Durham, NC, USA.
authors.forename: J L
authors.initials: JL
authors.lastname: Todd
authors.forename: J
authors.initials: J
authors.lastname: Lakey
authors.forename: D
authors.initials: D
authors.lastname: Howell
authors.forename: M
authors.initials: M
authors.lastname: Reidy
authors.forename: D
authors.initials: D
authors.lastname: Zaas
mesh_terms: D000368:Aged; D006801:Humans; D006975:Hypertension, Portal / Q000175:diagnosis / Q000382:microbiology* / Q000473:pathology; D008099:Liver / Q000382:microbiology / Q000473:pathology; D008107:Liver Diseases / Q000175:diagnosis / Q000382:microbiology* / Q000473:pathology; D008168:Lung / Q000382:microbiology / Q000473:pathology; D016040:Lung Transplantation / Q000009:adverse effects*; D008297:Male; D015269:Mycobacterium avium Complex / Q000472:pathogenicity; D015270:Mycobacterium avium-intracellulare Infection / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D011379:Prognosis