Hemodynamic effects of peptide fragments of differentiation factor HLDF.
Hemodynamic activity of peptides from differentiation factor HLDF (promyelocytic HL-60 line) was studied on WKY and SHR-SP rats. Intravenous infusion of the test peptides was accompanied by changes in blood pressure and heart rate, which depended on the structure of peptides and functional activity of the organism and differed in normotensive and hypertensive animals.
Rzhevskii
D I
DI
Laboratory of Biological Tests, Branch of the M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Pushchino. rzhevsky_di@rambler.ru
Dranitsyna
S M
SM
Baidakova
L K
LK
Myrashev
A N
AN
Kostanyan
I A
IA
D000595:Amino Acid Sequence; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects*; D007262:Infusions, Intravenous; D008297:Male; D008969:Molecular Sequence Data; D009363:Neoplasm Proteins / Q000235:genetics*; D010455:Peptides / Q000008:administration & dosage / Q000235:genetics / Q000494:pharmacology*; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D013045:Species Specificity; D013997:Time Factors
D009363:Neoplasm Proteins; D010455:Peptides; C091149:cell differentiation factor 8.2-kDa