Celiac disease associated antibodies in persons with latent autoimmune diabetes of adult and type 2 diabetes.
BACKGROUND
Celiac Disease (CD) is present in 1-16.4% of patients with type 1 diabetes mellitus. The most important serological markers of CD are anti-endomysial (EMA), anti-tissue transglutaminase (tTGA) and antigliadin antibodies (AGA).


OBJECTIVE
The objective of this work is to determine the frequency of tTGA and/or AGA in latent autoimmune diabetes of adult (LADA) and subjects with type 2 diabetes (T2DM), as well as to evaluate their relation with several clinical and biochemical characteristics.


METHODS
Forty three subjects with LADA and 99 with T2DM were studied. The presence of AGA, tTGA was determined in the sera of these patients. The variables: sex, age, duration of diabetes, treatment, body mass index (BMI) and fasting blood glucose concentration were also recorded.


RESULTS
No differences were found in the frequency of celiac disease associated antibodies between LADA and T2DM subjects. The presence of celiac disease related antibodies was more frequent in patients with a normal or low BMI.


CONCLUSIONS
Celiac disease does not seem to be related with pancreatic autoimmunity in type 2 diabetes. Celiac disease causes a decrease of body mass index in type 2 diabetes while pancreatic islet autoimmunity in this entity masks this effect.
Sánchez
J C
JC
Department of Diabetes Mellitus Immunity, National Institute of Endocrinology, Zapata and D, Vedado, Havana 10 400, Cuba.
Cruz
Julio Cesar Sánchez
JC
Cabrera-Rode
E
E
Rode
Eduardo Cabrera
EC
Sorell
L
L
Gómez
Luis Sorell
LS
Galvan
J A
JA
Cabrera
José A Galvan
JA
Hernandez
A
A
Ortega
Ania Hernandez
AH
Molina
G
G
Mato
Gisela Molina
GM
Perich
P A
PA
Amador
Pedro A Perich
PA
Licea
M E
ME
Puig
Manuel E Licea
ME
Domínguez
E
E
Alonso
Emma Domínguez
ED
Díaz-Horta
O
O
Díaz-Horta
Oscar
O
D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000276:immunology*; D015992:Body Mass Index; D002446:Celiac Disease / Q000276:immunology*; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology*; D003924:Diabetes Mellitus, Type 2 / Q000276:immunology*; D005260:Female; D005903:Gliadin / Q000276:immunology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011503:Transglutaminases / Q000276:immunology
D001323:Autoantibodies; D005903:Gliadin; D011503:Transglutaminases