CD36 is a receptor for oxidized high density lipoprotein: implications for the development of atherosclerosis.
Atherosclerotic plaques result from the excessive deposition of cholesterol esters derived from lipoproteins and lipoprotein fragments. Tissue macrophage within the intimal space of major arterial vessels have been shown to play an important role in this process. We demonstrate in a transfection system using two human cell lines that the macrophage scavenger receptor CD36 selectively elicited lipid uptake from Cu(2+)-oxidized high density lipoprotein (HDL) but not from native HDL or low density lipoprotein (LDL). The uptake of oxHDL displayed morphological and biochemical similarities with the CD36-dependent uptake of oxidized LDL. CD36-mediated uptake of oxidized HDL by macrophage may therefore contribute to atheroma formation.
Thorne
Rick F
RF
Cancer Research Unit, School of Biomedical Science, Faculty of Health, The University of Newcastle, NSW 2308, Australia. Rick.Thorne@newcastle.edu.au
Mhaidat
Nizar M
NM
Ralston
Kylie J
KJ
Burns
Gordon F
GF
D050197:Atherosclerosis / Q000209:etiology*; D018955:CD36 Antigens / Q000502:physiology*; D045744:Cell Line, Tumor; D002478:Cells, Cultured; D003300:Copper; D006801:Humans; D050356:Lipid Metabolism; D008075:Lipoproteins, HDL / Q000378:metabolism* / Q000502:physiology; D008077:Lipoproteins, LDL; D008264:Macrophages / Q000166:cytology / Q000378:metabolism; D010084:Oxidation-Reduction; D018110:Receptors, Lipoprotein / Q000502:physiology*; D014162:Transfection
D018955:CD36 Antigens; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D018110:Receptors, Lipoprotein; C031616:high density lipoprotein receptors; C099252:oxidized low density lipoprotein; D003300:Copper