title: HIV-1 subtypes in pregnant women in the UK.
abstract: We analyse the distribution of HIV-1 subtypes in HIV-1-seropositive samples from 333,270 residual neonatal dried blood spot samples tested for routine newborn screening tests in the UK between July 1999 and December 2002. Of the 813 antibody-positive samples shown to contain passively acquired, maternal HIV-1 for which subtyping was attempted, 333 (41%) could not be subtyped due to cross-reactivity or low values of the assay results, and 480 (59%) were classified as B (35, 7.3%) or non-B (445, 92.7%). The proportions of subtyped B samples differed significantly (P=0.004) between those from neonates whose mothers were born in the UK (21.4%) and those from neonates whose mothers were known to be born abroad (7%). Using a serological approach to establish viral serotype, we document the distribution of HIV-1 subtypes in infected pregnant women in the UK.
authors.affiliation: Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, UK. M.Cortina@ich.ucl.ac.uk
authors.forename: M
authors.initials: M
authors.lastname: Cortina-Borja
authors.forename: D
authors.initials: D
authors.lastname: Williams
authors.forename: W D
authors.initials: WD
authors.lastname: Cubitt
authors.forename: P A
authors.initials: PA
authors.lastname: Tookey
authors.forename: M-L
authors.initials: ML
authors.lastname: Newell
authors.forename: C S
authors.initials: CS
authors.lastname: Peckham
mesh_terms: D015492:AIDS Serodiagnosis / Q000379:methods; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D005260:Female; D015658:HIV Infections / Q000453:epidemiology / Q000821:virology*; D015497:HIV-1 / Q000145:classification*; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000453:epidemiology / Q000821:virology*; D006113:United Kingdom / Q000453:epidemiology