title: [Preparation of biodegradable and sustained release gel of tinidazole].
abstract: The objective of this study was to prepare a biodegradable poly (DL-lactide) injectable gel of tinidazole. The formulation parameters evaluated in this study included polymer molecular weight, polymer concentration, solvent and drug loading, and orthogonal design was used to optimize the formulation. The preferable formulation was that 30% (w/w) poly(DL-lactide) (MW is 5 700) dissolved in 70% (w/w) N-methyl-2-pyrrolidone with 4%-6% (w/w) tinidazole.
authors.affiliation: College of Light Industry and Food Science, South China University of Technology, Guangzhou 510640, China. yml@biochemzx.com
authors.forename: Yuyue
authors.initials: Y
authors.lastname: Qin
authors.forename: Lin
authors.initials: L
authors.lastname: Li
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.forename: Minglong
authors.initials: M
authors.lastname: Yuan
authors.forename: Yanxin
authors.initials: Y
authors.lastname: Zhu
authors.forename: Siyuan
authors.initials: S
authors.lastname: Guo
mesh_terms: D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000737:chemistry*; D005782:Gels; D019344:Lactic Acid / Q000737:chemistry*; D011091:Polyesters; D011108:Polymers / Q000737:chemistry*; D013678:Technology, Pharmaceutical / Q000379:methods; D014011:Tinidazole / Q000008:administration & dosage*
chemical_list: D003692:Delayed-Action Preparations; D004337:Drug Carriers; D005782:Gels; D011091:Polyesters; D011108:Polymers; D014011:Tinidazole; D019344:Lactic Acid; C033616:poly(lactide)