[Solitary fibrous tumor: a clinico-morphological and immunohistochemical study].
Solitary fibrous tumor is a rare neoplasm which may occur at any site although it is more frequent in the pleura, mediastinum and lung. The study used 4 cases of tumor localization in the pleura and orbit. Three cases presented as a "hemangiopericytic" variety of spindle cells; there were numerous giant cells in orbit tumor. Solitary fibrous tumor revealed enhanced expression of vimentin, CD34, bel-2 and CD99. Expression of S-100, desmine and non-striated muscle actin was found in few cells in some cases. Such features as large size (over 10 cm), necrosis, high cellularity, nuclear polymorphism and high mitotic index (more than 4 mitoses within 4 visual fields, at high magnification) were used as malignancy criteria:. Tumor histological pattern of "hemangiopericytic" variety could be reliably identified thanks to immunohistochemical procedure.
Leenman
E E
EE
Popov
S D
SD
Dvorakovskaia
I V
IV
Arsen'ev
A I
AI
Pozharisskiĭ
K M
KM
D000071443:12E7 Antigen; D000199:Actins / Q000032:analysis; D000368:Aged; D015703:Antigens, CD / Q000032:analysis; D018952:Antigens, CD34 / Q000032:analysis; D014408:Biomarkers, Tumor / Q000032:analysis*; D015815:Cell Adhesion Molecules / Q000032:analysis; D002648:Child; D003893:Desmin / Q000032:analysis; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D008940:Mitotic Index; D009336:Necrosis; D018218:Neoplasms, Fibrous Tissue / Q000737:chemistry* / Q000473:pathology*; D011110:Polymorphism, Genetic; D009418:S100 Proteins / Q000032:analysis; D014746:Vimentin / Q000032:analysis
D000071443:12E7 Antigen; D000199:Actins; D015703:Antigens, CD; D018952:Antigens, CD34; D014408:Biomarkers, Tumor; C061828:CD99 protein, human; D015815:Cell Adhesion Molecules; D003893:Desmin; D009418:S100 Proteins; D014746:Vimentin