title: Efficacy of tonsillectomy plus methylprednisolone pulse therapy for a child with Henoch-Schoenlein purpura nephritis.
abstract: Henoch-Schoenlein purpura (HSP) is a systemic disorder characterized by a leukocytoplastic vasculitis involving small vessels with the deposition of immunoglobulin A (IgA) immune complexes. Renal involvement is the principal cause of morbidity and mortality in children with HSP. We report here an 11-year-old boy with Henoch-Schoenlein purpura nephritis (HSPN) accompanied by recurrent purpura and persistent nephropathy despite conventional therapy such as prednisolone, methylprednisolone pulse therapy and immunosuppressive agent (Mizoribine). The patient was treated with tonsillectomy plus methylprednisolone pulse therapy. This treatment decreased proteinuria, induced disappearance of microscopic hematuria, and improved renal pathological findings. Tonsillectomy plus methylprednisolone pulse is effective and useful therapy for some children with recurrent purpura and persistent nephropathy.
authors.affiliation: Department of Pediatrics, Fukushima Medical University School of Medicine, Japan. tomo@fmu.ac.jp
authors.forename: Yukihiko
authors.initials: Y
authors.lastname: Kawasaki
authors.forename: Kazuhide
authors.initials: K
authors.lastname: Suyama
authors.forename: Ayumi
authors.initials: A
authors.lastname: Matsumoto
authors.forename: Kei
authors.initials: K
authors.lastname: Takano
authors.forename: Koichi
authors.initials: K
authors.lastname: Hashimoto
authors.forename: Sigeo
authors.initials: S
authors.lastname: Suzuki
authors.forename: Junzo
authors.initials: J
authors.lastname: Suzuki
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Suzuki
authors.forename: Mitsuaki
authors.initials: M
authors.lastname: Hosoya
mesh_terms: D002648:Child; D006801:Humans; D011695:IgA Vasculitis / Q000188:drug therapy* / Q000601:surgery*; D007668:Kidney / Q000473:pathology; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage* / Q000627:therapeutic use*; D020551:Pulse Therapy, Drug; D014068:Tonsillectomy
chemical_list: D008775:Methylprednisolone