Antinociceptive effect and acute toxicity of the essential oil of Hyptis fruticosa in mice.
The essential oil of the Hyptis fruticosa leaves was analyzed by GC/MS and evaluated for antinociceptive property as well as acute toxicity in mice. The essential oil, at doses of 100, 200, and 400 mg/kg (s.c.), produced significant inhibition of acetic acid-induced writhing, but did not manifest a significant effect in hot-plate test. There was no acute toxicity at doses up to 5 g/kg. Bicyclogermacrene, 1,8-cineole, alpha-pinene, and beta-caryophyllene were the major compounds detected in the essential oil.
Menezes
Igor A C
IA
Physiology Department, Federal University of Sergipe, São Cristovão, Brazil. igormenezes@bol.com.br
Marques
Maxsuel S
MS
Santos
Thiago C
TC
Dias
Kellyane S
KS
Silva
Aline B L
AB
Mello
Iderjane C M
IC
Lisboa
Ana C C D
AC
Alves
Péricles B
PB
Cavalcanti
Sócrates C H
SC
Marçal
Rosilene M
RM
Antoniolli
Angelo R
AR
D019342:Acetic Acid; D000700:Analgesics / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D006358:Hot Temperature; D031331:Hyptis; D008297:Male; D051379:Mice; D010146:Pain / Q000139:chemically induced / Q000517:prevention & control*; D010147:Pain Measurement / Q000187:drug effects; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use
D000700:Analgesics; D010936:Plant Extracts; D019342:Acetic Acid