Selenium-based safety-catch linker: solid-phase synthesis of vinyl-substituted oxadiazoles and triazoles.
Vinyl-substituted oxadiazoles and triazoles were prepared through hydrazinolysis, acylation, cyclocondensation, and elimination of selenium resins. The polystyrene-supported resins used here not only facilitate separation of products but also serve as a pro-vinyl safety-catch linker.
Wang
Yu-Guang
YG
Department of Chemistry, Zhejiang University (XixiCampus), Hangzhou 310028, PR China.
Xu
Wei-Ming
WM
Huang
Xian
X
D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D015394:Molecular Structure; D016566:Organoselenium Compounds / Q000737:chemistry*; D010069:Oxadiazoles / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism; D014230:Triazoles / Q000138:chemical synthesis*
D016566:Organoselenium Compounds; D010069:Oxadiazoles; D014230:Triazoles