title: 8-Isoprostane in nasally exhaled breath condensate in different pediatric lung diseases.
abstract: OBJECTIVE
  Increased levels of 8-isoprostane were found in various human lung diseases suggesting 8-isoprostane as a marker of pulmonary oxidative stress in vivo. The exact role in pediatric lung diseases has not been defined yet. The goal of this study was to clarify the role of 8-isoprostane in nasally exhaled breath condensate as possible marker of oxidative stress in children with different lung diseases.
  
  
  METHODS
  Levels of 8-isoprostane were measured in nasally exhaled breath condensate of 29 cystic fibrosis patients, 19 children with a history of wheezing episodes, 8 infants with acute respiratory tract infection and 53 healthy subjects using a specific enzyme immunoassay.
  
  
  RESULTS
  Levels of 8-isoprostane did neither discriminate between different disease groups nor correlate with lung function in cystic fibrosis patients.
  
  
  CONCLUSIONS
  Levels of 8-isoprostane in nasally exhaled breath condensate do not reflect oxidative stress in children with different lung diseases.
authors.affiliation: Dr. von Haunersches Kinderspital, Ludwig-Maximilians-University, Lindwurmstr. 4, 80337 Munich, Germany.
authors.forename: P
authors.initials: P
authors.lastname: Latzin
authors.forename: J
authors.initials: J
authors.lastname: Beck-Ripp
authors.forename: D
authors.initials: D
authors.lastname: Hartl
authors.forename: A
authors.initials: A
authors.lastname: Bartenstein
authors.forename: J
authors.initials: J
authors.lastname: Noss
authors.forename: Matthias
authors.initials: M
authors.lastname: Griese
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D015415:Biomarkers / Q000032:analysis; D001944:Breath Tests; D002648:Child; D002675:Child, Preschool; D015237:Dinoprost / Q000031:analogs & derivatives* / Q000032:analysis; D006801:Humans; D007118:Immunoassay; D007223:Infant; D008171:Lung Diseases / Q000378:metabolism*; D018384:Oxidative Stress; D012129:Respiratory Function Tests; D018709:Statistics, Nonparametric
chemical_list: D015415:Biomarkers; C075750:8-epi-prostaglandin F2alpha; D015237:Dinoprost