Somatostatin sst4 ligands: chemistry and pharmacology.
Several classes of compounds (thioureas, ureas, beta-glucosides, sulfonamides, and cyclic peptides) show enhanced binding affinity and selectivity at somatostatin subtype 4 receptors (sst4). Pharmacophore models have recently been proposed to explain receptor subtype selectivity. The chemistry and therapeutic potential of sst4 ligands will be the subject of this review.
Crider
A Michael
AM
Department of Pharmaceutical Sciences, School of Pharmacy, Southern Illinois University Edwardsville, Campus Box 2000, Edwardsville, IL 62026-2000, USA. mcrider@siue.edu
Witt
Ken A
KA
D000818:Animals; D006801:Humans; D008024:Ligands; D008565:Membrane Proteins / Q000819:agonists*; D015394:Molecular Structure; D010456:Peptides, Cyclic / Q000737:chemistry / Q000494:pharmacology; D017481:Receptors, Somatostatin / Q000819:agonists*; D013004:Somatostatin / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology
D008024:Ligands; D008565:Membrane Proteins; D010456:Peptides, Cyclic; D017481:Receptors, Somatostatin; C098681:somatostatin receptor subtype-4; D013004:Somatostatin