[In-vitro susceptibilites to levofloxacin and various antibacterial agents of 18,639 clinical isolates obtained from 77 centers in 2004].
A total of 18,639 clinical isolates in 19 species collected from 77 centers during 2004 in Japan were tested for their susceptibility to fluoroquinolones (FQs) and other selected antibiotics. The common respiratory pathogens, Streptococcus pyogenes, Streptococcus pneumoniae, Moraxella catarrhalis and Haemophilus influenzae showed a high susceptible rate against FQs. The isolation rate of beta lactamase non-producing ampicillin-resistant H. influenzae was approximately three times as large as those of western countries. Most strains of Enterobacteriaceae were also susceptible to FQs. The resistance rate of Escherichia coli against FQs has however been rapidly increasing so far as we surveyed since 1994. The FQs-resistant rate in methicillin-resistant Staphylococcus aureus (MRSA) showed approximately 90% except for 36%. of sitafloxacin while FQs-resistant rate in methicillin-susceptible S. aureus (MSSA) was around 5%. The FQs-resistant rate of methicillin-resistant coagulase negative Staphylococci (MRCNS) was also higher than that of methicillin-susceptible coagulase negative Staphylococci (MSCNS), however, it was lower than that of MRSA. In Pseudomonas aeruginosa clinical isolates, 32-34% from UTI and 15-19% of from RTI was resistant to FQs. Acinetobacter spp. showed a high susceptibility to FQs. Although FQs-resistant Neisseria gonorrhoeae have not been increased in western countries, it is remarkably high in Japan. In this survey, isolates of approximately 85% was resistant to FQs.
Yamaguchi
Keizo
K
Department of Microbiology and Infectious Diseases, Toho University Faculty of Medicine.
Ohno
Akira
A
Ishii
Yoshikazu
Y
Tateda
Kazuhiro
K
Iwata
Morihiro
M
Kanda
Makoto
M
Tsujio
Yoshiko
Y
Kimoto
Hiroya
H
Kaimori
Mitsuomi
M
Nakamura
Toshihiko
T
Kawamura
Chizuko
C
Nishimura
Masaharu
M
Akizawa
Koji
K
Katayama
Yosei
Y
Matsuda
Keiko
K
Hayashi
Tasuku
T
Yasujima
Minoru
M
Kasai
Takeshi
T
Kimura
Masahiko
M
Tominaga
Makoto
M
Miki
Makoto
M
Nakanowatari
Susumu
S
Nakagawa
Takuo
T
Kaku
Mitsuo
M
Kanemitsu
Keiji
K
Kunishima
Hiroyuki
H
Toyoshima
Shunkoh
S
Sakurai
Masanori
M
Shiotani
Joji
J
Sugita
Akihiro
A
Ito
Tatsumi
T
Okada
Jun
J
Suwabe
Akira
A
Yamahata
Kumiko
K
Yoneyama
Akiko
A
Kumasaka
Kazunari
K
Yamane
Nobuo
N
Koike
Kazuhiko
K
Ieiri
Tamio
T
Kominami
Hidenori
H
Yamada
Toshiyuki
T
Oguri
Toyoko
T
Itoh
Kouichi
K
Watanabe
Kiyoaki
K
Kobayashi
Yoshio
Y
Ohtake
Teruko
T
Uchida
Takashi
T
Totsuka
Kyoichi
K
Murakami
Masami
M
Yomoda
Sachie
S
Takahashi
Ayako
A
Okamoto
Hideyuki
H
Inuzuka
Kazuhisa
K
Yamazaki
Kenichiro
K
Gonda
Hideo
H
Yamashita
Takanori
T
Yamaguchi
Ikuo
I
Okada
Motoi
M
Ikari
Hiromi
H
Kurosawa
Naomi
N
Fujimoto
Yoshinori
Y
Ishigo
Shiomi
S
Asano
Yuko
Y
Mikio
Mori
M
Kano
Ichino
I
Nagano
Eiko
E
Kageyama
Fumio
F
Shaku
Etsuko
E
Kanno
Harushige
H
Aihara
Masanori
M
Gemma
Hitoshi
H
Uemura
Keiichi
K
Miyajima
Eiji
E
Maesaki
Shighefumi
S
Hashikita
Giichi
G
Horii
Toshinobu
T
Sumitomo
Midori
M
Yoshimura
Hitoshi
H
Hiraoka
Minoru
M
Wada
Hideo
H
Yuzuki
Yosuke
Y
Ikeda
Norio
N
Baba
Hisashi
H
Soma
Masayuki
M
Yamamoto
Tsuyoshi
T
Ichiyama
Satoshi
S
Kinosita
Syohiro
S
Kawano
Seiji
S
Fujita
Shinichi
S
Kageoka
Takeshi
T
Hongo
Toshiharu
T
Okabe
Hidetoshi
H
Tatewaki
Kenichi
K
Moro
Kunihiko
K
Oka
Mikio
M
Niki
Yoshihito
Y
Yoshida
Haruyoshi
H
Yamashita
Masanobu
M
Kusano
Nobuchika
N
Mihara
Eiichiro
E
Nose
Motoko
M
Fushiwaki
Takeshi
T
Kuwabara
Masao
M
Fujiue
Yoshihiro
Y
Shimuzu
Akira
A
Takubo
Takayuki
T
Kusakabe
Tadashi
T
Hinoda
Yuji
Y
Tanaka
Nobuaki
N
Takahashi
Hakuo
H
Heijyou
Hitoshi
H
Okazaki
Toshiro
T
Asai
Koji
K
Kawahara
Kunimitsu
K
Masuda
Junichi
J
Sano
Reiko
R
Taminato
Tomohiko
T
Negayama
Kiyoshi
K
Matsuo
Syuji
S
Komatsu
Masaru
M
Sugiura
Tetsuro
T
Murase
Mitsuharu
M
Hiramatsu
Kazufumi
K
Yamane
Nobuhisa
N
Nakasone
Isao
I
Hirakata
Yoichi
Y
Kohno
Shigeru
S
Aizawa
Hisamichi
H
Honda
Junichi
J
Hamazaki
Naotaka
N
Okayama
Akihiko
A
Ono
Junko
J
Aoki
Yosuke
Y
Okada
Kaoru
K
Miyanohara
Hiroaki
H
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001424:Bacterial Infections / Q000382:microbiology*; D004352:Drug Resistance, Microbial; D024841:Fluoroquinolones / Q000494:pharmacology; D006090:Gram-Negative Bacteria / Q000187:drug effects* / Q000302:isolation & purification*; D006095:Gram-Positive Cocci / Q000187:drug effects* / Q000302:isolation & purification*; D016987:Gram-Positive Rods / Q000187:drug effects* / Q000302:isolation & purification*; D006801:Humans; D007564:Japan; D013997:Time Factors
D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones