title: Trace measurement of phenothiazine drugs in tablets by micellar-enhanced fluorophotometric method.
abstract: It was found that in buffer solution of pH 7.0, the addition of sodium dodecyl sulfate (SDS) to the solution of phenothiazine drugs, such as chlorpromazine, promethazine and trifluoperazine, showed a remarkable enhancement of their fluorescence intensity. A further study proved that the phenothiazine drugs can be determined by fluorophotometric method in micellar system. Under optimal conditions, there was a good linear relationship between fluorescence intensity and phenothiazine compounds concentration, and the detection limit of 3.0 x 10(-8) M chlorpromazine, 3.0 x 10(-8) M promethazine and 1.5 x 10(-8) M trifluoperazine (S/N=3) were also obtained. This method has been used to determine phenothiazine drugs in tablets with satisfactory results.
authors.affiliation: College of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, PR China. yanggongjun888@163.com
authors.forename: Gong-Jun
authors.initials: GJ
authors.lastname: Yang
authors.forename: Xi-Long
authors.initials: XL
authors.lastname: Qu
authors.forename: Ming
authors.initials: M
authors.lastname: Shen
authors.forename: Qi-Shu
authors.initials: QS
authors.lastname: Qu
authors.forename: Chen-Ying
authors.initials: CY
authors.lastname: Wang
authors.forename: Ai-Ping
authors.initials: AP
authors.lastname: Zhu
authors.forename: Xiao-Ya
authors.initials: XY
authors.lastname: Hu
mesh_terms: D015590:Fluorophotometry / Q000379:methods*; D008823:Micelles; D010640:Phenothiazines / Q000032:analysis*; D012967:Sodium Dodecyl Sulfate / Q000737:chemistry; D013607:Tablets
chemical_list: D008823:Micelles; D010640:Phenothiazines; D013607:Tablets; D012967:Sodium Dodecyl Sulfate