title: Neoglycopeptide dendrimer libraries as a source of lectin binding ligands.
abstract: [structure: see text] A 15 625-membered peptide dendrimer combinatorial library was acylated with an alpha-C-fucosyl residue at its four N-termini and screened for binding to fucose-specific lectins. Dendrimer FD2 (Fuc-alpha-CH2CO-Lys-Pro-Leu)4(Lys-Phe-Lys-Ile)2Lys-His-Ile-NH2 was identified as a potent ligand against Ulex europaeus lectin UEA-I (IC50 = 11 microM) and Pseudomonas aeruginosa lectin PA-IIL (IC50 = 0.14 microM).
authors.affiliation: Department of Chemistry and Biochemistry, University of Berne, Freiestrasse 3, CH-3012, Berne, Switzerland.
authors.forename: Elena
authors.initials: E
authors.lastname: Kolomiets
authors.forename: Emma M V
authors.initials: EM
authors.lastname: Johansson
authors.forename: Olivier
authors.initials: O
authors.lastname: Renaudet
authors.forename: Tamis
authors.initials: T
authors.lastname: Darbre
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Reymond
mesh_terms: D030562:Databases, Protein; D050091:Dendrimers / Q000737:chemistry* / Q000378:metabolism*; D004797:Enzyme-Linked Immunosorbent Assay; D005643:Fucose / Q000737:chemistry; D006020:Glycopeptides / Q000737:chemistry* / Q000378:metabolism*; D037102:Lectins / Q000378:metabolism*; D008024:Ligands; D015394:Molecular Structure; D011485:Protein Binding
chemical_list: D050091:Dendrimers; D006020:Glycopeptides; D037102:Lectins; D008024:Ligands; D005643:Fucose