Immunogenetic control of antibody responsiveness in a malaria endemic area.
This study builds upon the established genetic control of antimalarial immune responses and prior association studies by using a family-based approach, transmission disequilibrium testing, to identify immune response genes that influence antibody responses to Plasmodium falciparum infection in an endemic Tanzanian population. Candidate polymorphisms are within the interleukin-1 (IL-1) gene cluster, the IL-10 promoter, Major histocompatibility complex class II and III, the 5q31-q33 region, and the T-Cell Receptor beta variable region. There was a significant association between the IL1RN alleles and total IgE. Weak evidence for association was present between polymorphisms in the IL10 promoter region and both anti-P falciparum IgE and IgG4 antibodies.
Carpenter
Danielle
D
Institute of Integrative and Comparative Biology, University of Leeds, Leeds, England. d.carpenter@leeds.ac.uk
Abushama
Hind
H
Bereczky
Sándor
S
Färnert
Anna
A
Rooth
Ingegerd
I
Troye-Blomberg
Marita
M
Quinnell
Rupert J
RJ
Shaw
Marie-Anne
MA
D000913:Antibodies, Protozoan / Q000096:biosynthesis* / Q000235:genetics / Q000276:immunology; D000917:Antibody Formation / Q000235:genetics; D019353:Endemic Diseases; D005802:Genes, MHC Class II; D005838:Genotype; D006681:HLA-D Antigens / Q000235:genetics; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D007073:Immunoglobulin E / Q000096:biosynthesis* / Q000235:genetics / Q000276:immunology; D007074:Immunoglobulin G / Q000096:biosynthesis* / Q000235:genetics / Q000276:immunology; D007375:Interleukin-1 / Q000235:genetics; D016753:Interleukin-10 / Q000235:genetics; D018793:Interleukin-13 / Q000235:genetics; D015847:Interleukin-4 / Q000235:genetics; D016778:Malaria, Falciparum / Q000453:epidemiology / Q000235:genetics* / Q000276:immunology; D018598:Minisatellite Repeats; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic / Q000235:genetics; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000235:genetics; D017472:Receptors, Interleukin-1 / Q000235:genetics; D013636:Tanzania / Q000453:epidemiology; D018418:Th2 Cells / Q000276:immunology
D000913:Antibodies, Protozoan; D006681:HLA-D Antigens; C508609:IL10 protein, human; C508598:IL4 protein, human; D007074:Immunoglobulin G; D007375:Interleukin-1; D018793:Interleukin-13; D016693:Receptors, Antigen, T-Cell, alpha-beta; D017472:Receptors, Interleukin-1; D016753:Interleukin-10; D015847:Interleukin-4; D007073:Immunoglobulin E