Comparison of hydroxyzine and doxepin in treatment of pruritus due to sulfur mustard.
OBJECTIVE
To compare the safety and efficacy of doxepin and hydroxyzine in the treatment of chronic pruritus due to exposure to sulfur mustard.


METHODS
In a randomized, double-blind safety and efficacy study, 50 patients with chronic pruritus were given either doxepin 10 mg/d or hydroxyzine 25 mg/d for 4 weeks. Pruritic score was calculated for each patient before treatment and 1 month after.


RESULTS
After treatment, the mean pruritic scores +/- SD of the hydroxyzine and doxepin groups were 16.7+/-2.3 and 17.8+/-2.5, respectively. The severity of pruritus was decreased in 80% of patients in the hydroxyzine group and 75% in the doxepin group (P=.786). Eighteen patients in the hydroxyzine group and 14 patients in the doxepin group reported sedation.


CONCLUSIONS
Both hydroxyzine and doxepin are effective and have equivalent results in controlling the symptoms of patients with chronic pruritus due to exposure to sulfur mustard.
Shohrati
Majid
M
Research Center of Chemical Injuries, Baqiyatallah Medical Sciences University, Tehran, Iran.
Tajik
Ali
A
Harandi
Ali Amini
AA
Davoodi
Seyed Masoud
SM
Akmasi
Mahmood
M
D000328:Adult; D000982:Antipruritics / Q000627:therapeutic use*; D002619:Chemical Warfare Agents / Q000506:poisoning; D004311:Double-Blind Method; D004316:Doxepin / Q000627:therapeutic use*; D006801:Humans; D006919:Hydroxyzine / Q000627:therapeutic use*; D009151:Mustard Gas / Q000506:poisoning*; D011537:Pruritus / Q000139:chemically induced* / Q000188:drug therapy*
D000982:Antipruritics; D002619:Chemical Warfare Agents; D004316:Doxepin; D006919:Hydroxyzine; D009151:Mustard Gas