title: Cardiac activity and blood pressure in rats during selective blockade of various subtypes of muscarinic cholinoceptors.
abstract: Cardiac activity and blood pressure in adult rats were recorded during selective blockade of cholinoceptors. Blockade of muscarinic M1 and M2-cholinoceptors had little effect on cardiac activity. Blockade of muscarinic M3-cholinoceptors was followed by heart acceleration. The data suggest that the tonic inhibitory influence of the vagus nerve is mediated via cardiac muscarinic M3-cholinoceptors. Electrostimulation of the right vagus nerve during selective blockade of various subtypes of muscarinic cholinoceptors was followed by the decrease in heart rate. Our results indicate that muscarinic cholinoceptors play a role in the immediate inhibition of cardiac activity upon vagus nerve stimulation.
authors.affiliation: Department of Anatomy, Physiology, and Human Health Care, Tatar State Humanitarian-and-Pedagogical University; Department of Normal Physiology, Kazan State Medical University. nafisaz@mail.ru.
authors.forename: T L
authors.initials: TL
authors.lastname: Zefirov
authors.forename: N I
authors.initials: NI
authors.lastname: Ziyatdinova
authors.forename: L R
authors.initials: LR
authors.lastname: Saifutdinova
authors.forename: A L
authors.initials: AL
authors.lastname: Zefirov
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D004558:Electric Stimulation; D004562:Electrocardiography; D005703:Gallamine Triethiodide / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects*; D018727:Muscarinic Antagonists / Q000494:pharmacology*; D010880:Piperidines / Q000494:pharmacology*; D010890:Pirenzepine / Q000494:pharmacology*; D051381:Rats; D013997:Time Factors; D014630:Vagus Nerve / Q000502:physiology
chemical_list: D018727:Muscarinic Antagonists; D010880:Piperidines; D010890:Pirenzepine; C042375:4-diphenylacetoxy-1,1-dimethylpiperidinium; D005703:Gallamine Triethiodide