title: [Genetic markers of predisposition to an aggressive course of chronic C hepatitis].
abstract: The polymorphism of cytokine genes (11-1beta, IL-10, IL-6, and TGF-beta1) in patients with chronic C hepatitis and in healthy individuals was studied. The study found that the polymorphism of IL-1beta, IL-6, and TGF-beta1 may at least partially explain the genetic predisposition to an aggressive course of the disease with the development of terminal stage.
authors.forename: S M
authors.initials: SM
authors.lastname: Abdullaev
authors.forename: Iu I
authors.initials: IuI
authors.lastname: Tselishcheva
authors.forename: L M
authors.initials: LM
authors.lastname: Samokhodskaia
authors.forename: V V
authors.initials: VV
authors.lastname: Kvasovka
authors.forename: T M
authors.initials: TM
authors.lastname: Ignatova
authors.forename: T N
authors.initials: TN
authors.lastname: Krasnova
authors.forename: V N
authors.initials: VN
authors.lastname: Bochkov
authors.forename: N A
authors.initials: NA
authors.lastname: Mukhin
mesh_terms: D000293:Adolescent; D000328:Adult; D004247:DNA / Q000235:genetics*; D018450:Disease Progression; D005260:Female; D020022:Genetic Predisposition to Disease; D019698:Hepatitis C, Chronic / Q000097:blood / Q000150:complications / Q000235:genetics*; D006801:Humans; D016753:Interleukin-10 / Q000097:blood / Q000235:genetics*; D053583:Interleukin-1beta / Q000097:blood / Q000235:genetics*; D015850:Interleukin-6 / Q000097:blood / Q000235:genetics*; D008103:Liver Cirrhosis / Q000209:etiology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D011379:Prognosis; D012720:Severity of Illness Index; D053773:Transforming Growth Factor beta1 / Q000097:blood / Q000235:genetics*
chemical_list: D053583:Interleukin-1beta; D015850:Interleukin-6; D053773:Transforming Growth Factor beta1; D016753:Interleukin-10; D004247:DNA