title: [A case of advanced breast cancer with multiple liver metastases resistant to chemotherapy responding to high-dose toremifene].
abstract: A 47-year-old woman was admitted to our hospital for advanced breast cancer with multiple liver metastases and liver dysfunction in January 2004. EC (EPI combined with CPA), weekly PTX, and AI were performed but were not effective for that tumor. Therefore, high-dose TOR was started. Liver dysfunction recovered after administration of TOR, and primary tumor and liver metastases were evaluated as a partial response (PR). The same therapy has been performed for six months with no evidence of deterioration.
authors.affiliation: Dept. of General Surgery, Yokohama City University Medical Center.
authors.forename: Chizuru
authors.initials: C
authors.lastname: Matsumoto
authors.forename: Takashi
authors.initials: T
authors.lastname: Ishikawa
authors.forename: Nobuyoshi
authors.initials: N
authors.lastname: Momiyama
authors.forename: Takashi
authors.initials: T
authors.lastname: Chishima
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Ichikawa
authors.forename: Shinji
authors.initials: S
authors.lastname: Togo
authors.forename: Kenji
authors.initials: K
authors.lastname: Inui
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Shimada
mesh_terms: D000077384:Anastrozole; D018931:Antineoplastic Agents, Hormonal / Q000008:administration & dosage*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology; D002277:Carcinoma / Q000188:drug therapy* / Q000556:secondary; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D019008:Drug Resistance, Neoplasm; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy / Q000503:physiopathology / Q000556:secondary*; D008875:Middle Aged; D009570:Nitriles / Q000494:pharmacology; D011788:Quality of Life; D012074:Remission Induction; D017312:Toremifene / Q000008:administration & dosage*; D014230:Triazoles / Q000494:pharmacology
chemical_list: D018931:Antineoplastic Agents, Hormonal; D009570:Nitriles; D014230:Triazoles; D000077384:Anastrozole; D017312:Toremifene