title: [Safety issues of traditional Chinese medical preparations containing arsenic substances: review starting from Niuhuang Jiedu Pian (Wan)].
abstract: By comprehensively reviewing the origin and history of Niuhuang Jiedu Wan and its "derivatives", we studied the clinical records of realgar, investigated its clinical usage, dosage, efficacy, and toxicity in the literatures. We pinpointed the factors that might be associated with safety problems of Niuhuang Jiedu Pian (Wan) and other traditional Chinese medicine (TCM) preparations containing arsenic substances. In this article we also put forward suggestions for strengthening the surveillance and administration of similar TCM preparations.
authors.affiliation: Center or Drug reevaluation, State Food and Drug Administration, Beijing 100061, China.
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.forename: Si-Hua
authors.initials: SH
authors.lastname: Gao
authors.forename: Chao-fan
authors.initials: CF
authors.lastname: Zhou
authors.forename: Rui-chao
authors.initials: RC
authors.lastname: Lin
authors.forename: Chang-hua
authors.initials: CH
authors.lastname: Liu
mesh_terms: D020261:Arsenic Poisoning / Q000266:history / Q000517:prevention & control*; D001152:Arsenicals / Q000009:adverse effects* / Q000032:analysis / Q000266:history; D004338:Drug Combinations; D049673:History, 20th Century; D049674:History, 21st Century; D049690:History, Ancient; D049691:History, Medieval; D006801:Humans; D008516:Medicine, Chinese Traditional; D013440:Sulfides / Q000009:adverse effects* / Q000032:analysis / Q000266:history
chemical_list: D001152:Arsenicals; D004338:Drug Combinations; D013440:Sulfides; C058317:arsenic disulfide