title: Chronic neutrophilic leukaemia.
abstract: Chronic neutrophilic leukaemia is a rare myeloproliferative disease characterised by splenomegaly, sustained neutrophilia, raised vitamin B12 level and absence of the Philadelphia chromosome. We report a 74-year-old man who presented first with Sweet's syndrome and subsequently leukocytosis. He had splenomegaly, a raised vitamin B12 level, serum uric acid and neutrophil alkaline phosphatase score. Cytogenetic study of the marrow was normal and peripheral blood for BCR-ABL gene transcript was not detectable. He subsequently passed away with bronchopneumonia.
authors.affiliation: Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia. gingingan@yahoo.com
authors.forename: G G
authors.initials: GG
authors.lastname: Gan
authors.forename: J F J
authors.initials: JF
authors.lastname: Pasagna
authors.forename: G I
authors.initials: GI
authors.lastname: Eow
authors.forename: V S
authors.initials: VS
authors.lastname: Nadarajan
mesh_terms: D000368:Aged; D020533:Angiogenesis Inhibitors / Q000627:therapeutic use; D017809:Fatal Outcome; D006801:Humans; D016898:Interferon-alpha / Q000627:therapeutic use; D015467:Leukemia, Neutrophilic, Chronic / Q000097:blood / Q000175:diagnosis* / Q000188:drug therapy; D008297:Male; D016133:Polymerase Chain Reaction
chemical_list: D020533:Angiogenesis Inhibitors; D016898:Interferon-alpha