title: Bile leakage after hepatectomy for hepatolithiasis: risk factors and management.
abstract: BACKGROUND
  Bile leakage remains a major postoperative complication after liver resection. Bile leakage after hepatectomy for liver neoplasms has been well studied. However, the risk factors and management of this complication after liver resection for intrahepatic lithiasis has not been investigated.
  
  
  METHODS
  From January 1992 to June 2004, 312 consecutive patients with intrahepatic lithiasis underwent hepatic resections Sun Yet-san University. Perioperative risk factors pertaining to the development of bile leakage were identified using univariate and multivariate analysis. The management and outcome of these patients with bile leakage were evaluated.
  
  
  RESULTS
  Bile leakage developed in 23 (7.4%) of 312 patients. The multivariate logistic regression analysis identified that left hepatectomy (P=.024, odds ratio [OR]=3.695, 95% confidence interval [CI]: 1.185 to 11.517) and the period greater than 1 month between operative time and the latest acute cholangitis attack (P=.02, OR=4.144, 95% CI: 1.248 to 13.757) were the independent risk factors for development of bile leakage after hepatectomy for hepatolithiasis. The septic complications were higher in the patients with bile leakage than in those without bile leakage (ie, wound infection: 56.5% vs 13.5%, P=.001; subphrenic abscess: 21.7% vs 4.8%, P=.01; septicemia: 8.7% vs 0.7%, P=.029). Percutaneous drainage or combined endoscopic naso-biliary drainage was the first choice of treatment for bile leakage; 20 (87.0%) of 23 patients were treated by this method. One patient underwent re-operation for diffuse peritonitis due to withdrawal of T tube inadvertently at postoperative day 1. Two patients with bile leakage were re-operated due to uncontrollable hemobilia at postoperative day 5 and 12, respectively.
  
  
  CONCLUSIONS
  Patients who underwent hepatectomy at the period less than 1 month after the latest attack of acute cholangitis carry high risk for the development of bile leakage. Preoperative cholangiography to identify the aberrant hepatic duct for high risk patients and avoidance of hepatectomy at the acute phase of cholangitis are of critical importance to prevent bile leakage after hepatectomy. Percutaneous drainage is the primary and effective treatment for bile leakage.
authors.affiliation: Department of Hepatobiliary Surgery, the First Affiliated Hospital, Sun Yet-san University, Guangzhou, China.
authors.forename: Shao-Qiang
authors.initials: SQ
authors.lastname: Li
authors.forename: Li-Jian
authors.initials: LJ
authors.lastname: Liang
authors.forename: Bao-Gang
authors.initials: BG
authors.lastname: Peng
authors.forename: Ming-De
authors.initials: MD
authors.lastname: Lu
authors.forename: Jia-Ming
authors.initials: JM
authors.lastname: Lai
authors.forename: Dong-Ming
authors.initials: DM
authors.lastname: Li
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001646:Bile / Q000378:metabolism*; D002761:Cholangitis / Q000378:metabolism / Q000401:mortality / Q000601:surgery; D004322:Drainage; D005260:Female; D006498:Hepatectomy; D006801:Humans; D015994:Incidence; D020347:Lithiasis / Q000378:metabolism / Q000401:mortality* / Q000601:surgery*; D008099:Liver / Q000378:metabolism / Q000601:surgery; D016015:Logistic Models; D008136:Longevity; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000378:metabolism / Q000401:mortality* / Q000628:therapy; D012086:Reoperation; D012307:Risk Factors