Dopaminergic influences on changes in human tactile acuity induced by tactile coactivation.
As shown in animal experiments, dopaminergic mechanisms participate in N-methyl-D-aspartate (NMDA) receptor-dependent neuroplasticity. Dopamine is thought to play a similar role in humans, where it influences learning and memory. Here, we tested the dopaminergic action on learning in the tactile domain. To induce tactile non-associative learning, we applied a tactile coactivation protocol, which is known to improve tactile two-point discrimination of the stimulated finger. We studied the influence of a single oral dose of levodopa (25, 50, 100, 250 or 350 mg) administered preceding the coactivation protocol on changes in tactile performance in different groups of subjects. In addition, 3 x 100 mg levodopa was administered over a time period of 3 h in another group. Under placebo conditions, tactile two-point discrimination was improved on the coactivated index finger. Similar improvement was found when 25, 50 and 250 mg levodopa was applied. On the contrary, tactile improvement was completely eliminated by 1 x 100 and 3 x 100 mg levodopa. No drug effects were found on the left index finger indicating that the drug had no effect on performance per se. In contrast to previous findings in the motor and speech domain, we found that the administration of levodopa exerts either no or even negative effects on non-associative learning in the human somatosensory system. Whenever levodopa is used in neurorehabilitative context, it has to be kept in mind that beneficial effects in the motor or speech domain cannot be easily generalized to other systems.
Bliem
Barbara
B
Department for Neuroinformatics, Theoretical Biology, Exp. Neurobiology Lab, Ruhr-University Bochum, Bochum, Germany.
Frombach
Elke
E
Ragert
Patrick
P
Knossalla
Frauke
F
Woitalla
Dirk
D
Tegenthoff
Martin
M
Dinse
Hubert R
HR
D000328:Adult; D000704:Analysis of Variance; D001545:Benserazide / Q000008:administration & dosage; D004193:Discrimination Learning / Q000187:drug effects / Q000502:physiology*; D004298:Dopamine / Q000378:metabolism*; D015259:Dopamine Agents / Q000008:administration & dosage; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004347:Drug Interactions / Q000502:physiology; D005260:Female; D006801:Humans; D007980:Levodopa / Q000008:administration & dosage; D008297:Male; D012684:Sensory Thresholds / Q000187:drug effects / Q000502:physiology*; D013997:Time Factors; D014110:Touch / Q000187:drug effects / Q000502:physiology*
D015259:Dopamine Agents; D007980:Levodopa; D001545:Benserazide; D004298:Dopamine