title: MRI spectroscopy in screening of prostate cancer.
abstract: BACKGROUND
  The purpose of this study was to evaluate the suitability of MR Spectroscopy in screening for prostate cancer in comparison to T2-weighted MR imaging.
  
  
  METHODS
  Forty-six patients with biopsy confirmed prostate cancer underwent combined endorectal-body-phased-array MRI at 1.5T (Tesla). Twelve patients were additionally examined with 3D-spectroscopy sequence. The results of the spectroscopy were compared with the findings of T2-weighted MR imaging and the histological examination of radical prostatectomy specimens.
  
  
  RESULTS
  With 3D-spectroscopy, a choline+creatine/citrate-ratio of 0.45 for healthy tissue and a ratio of 1.90 for tumor tissue were found and a significant difference between the groups was demonstrated. In 6 cases diagnosis of tumor localization was improved with spectroscopy in comparison with T2-weighted imaging alone.
  
  
  CONCLUSIONS
  3D-spectroscopy is a suitable technique for improving MR imaging of prostate cancer. This method can improve the diagnostic accuracy of T2-weighted imaging alone. At present, 3D-CSI spectroscopy alone can not be recommended with sufficient validity.
authors.affiliation: Department of Radiology, Martha-Maria Hospital, Nuremberg, Germany.
authors.forename: Katja
authors.initials: K
authors.lastname: Goeb
authors.forename: Dirk G
authors.initials: DG
authors.lastname: Engehausen
authors.forename: F Steffen
authors.initials: FS
authors.lastname: Krause
authors.forename: Hans-Peter
authors.initials: HP
authors.lastname: Hollenbach
authors.forename: Gerald
authors.initials: G
authors.lastname: Niedobitek
authors.forename: Maike
authors.initials: M
authors.lastname: Buettner
authors.forename: Phroso
authors.initials: P
authors.lastname: Frangou
authors.forename: Karl
authors.initials: K
authors.lastname: Engelhard
mesh_terms: D000368:Aged; D002794:Choline / Q000032:analysis; D002951:Citrates / Q000032:analysis; D003401:Creatine / Q000032:analysis; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D008403:Mass Screening / Q000379:methods*; D008875:Middle Aged; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000378:metabolism; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D002951:Citrates; D003401:Creatine; D002794:Choline