title: Temporal lobe surgery in patients with normal MRI.
abstract: OBJECTIVE
  The surgical approach to nonlesional temporal lobe epilepsy presents a significant challenge due to uncertainties regarding the extent of resection necessary to result in a seizure-free state. To outline an optimum surgical strategy, an understanding of the clinical and diagnostic presentation of mesial and lateral temporal epilepsy is required in order to properly characterize the location of the ictal onset zone. This review focuses on several methods used to identify this ictal onset zone, with emphasis on the impact each modality has on surgical outcome.
  
  
  RESULTS
  Factors predicting an excellent surgical outcome include the presence of a discrete zone of low voltage fast activity and prolonged propagation time on the electroencephalogram, and the absence of metabolic dysfunction in the contralateral temporal lobe. Identifying epileptogenic regions in the temporal lobe using magnetic source imaging is a recent technique that has also yielded promising surgical outcomes. Recent prospective studies have shown that a temporal neocortical resection is very effective in providing a seizure free outcome given strict localization of the ictal onset zone to the lateral temporal region, highlighting the need for accurate characterization of mesial versus lateral nonlesional epilepsy.
  
  
  CONCLUSIONS
  With accurate identification of the ictal onset zone with intracranial electroencephalography, a tailored temporal resection can yield excellent surgical results.
authors.affiliation: New York University Comprehensive Epilepsy Center, New York, New York 10016, USA.
authors.forename: Deepak
authors.initials: D
authors.lastname: Madhavan
authors.forename: Ruben
authors.initials: R
authors.lastname: Kuzniecky
mesh_terms: D038481:Anterior Temporal Lobectomy / Q000379:methods*; D001931:Brain Mapping; D004833:Epilepsy, Temporal Lobe / Q000473:pathology* / Q000601:surgery*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*