Soluble Fas ligand: is it a critical mediator of toxic epidermal necrolysis and Stevens-Johnson syndrome?
Although soluble Fas ligand (sFasL) is an important candidate in toxic epidermal necrolysis (TEN) and Stevens-Johnson syndrome (SJS), Stur and colleagues report that elevated sFasL has been detected in maculopapular rashes. In addition to sFasL, other factors, including predisposing genetic factors, should also be investigated to determine their precise pathogenesis in TEN and SJS.
Murata
Junko
J
Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
Abe
Riichiro
R
D053222:Fas Ligand Protein / Q000378:metabolism*; D006801:Humans; D013262:Stevens-Johnson Syndrome / Q000209:etiology*
D053222:Fas Ligand Protein