title: Urinary F2-isoprostanes are poor prognostic indicators for the development of bronchopulmonary dysplasia.
abstract: OBJECTIVE
  Oxygen toxicity is thought to contribute to the development of bronchopulmonary dysplasia (BPD). Oxidant injury leads to formation of F(2)-isoprostanes (F(2)-IsoP). We hypothesized that urinary excretion of the stable metabolite of F(2)-IsoP, 8-iso-PGF(2alpha), would be higher in infants who develop BPD than those who did not.
  
  
  METHODS
  Forty infants <30-weeks gestational age (GA) were enrolled, 24 infants with BPD and 16 without BPD. Urine specimens were collected weekly and stored at -80 degrees C until analyzed. Urinary 8-iso-PGF(2alpha) was measured by gas chromatography/mass spectrometry (GC-MS) and normalized to creatinine excretion.
  
  
  RESULTS
  GA and birth weight (BW) were lower in infants who developed BPD than those who did not. Urinary 8-iso-PGF(2alpha) levels in the first or third weeks of age were not significantly different between the two groups.
  
  
  CONCLUSIONS
  Urinary excretion of 8-iso-PGF(2alpha) in early postnatal life in preterm infants is not correlated with the development of BPD.
authors.affiliation: Department of Pediatrics, Section of Neonatology, Baylor College of Medicine, Houston, TX, USA. reuters@siouxvalley.org
authors.forename: S D
authors.initials: SD
authors.lastname: Reuter
authors.forename: D J
authors.initials: DJ
authors.lastname: O'Donovan
authors.forename: S E
authors.initials: SE
authors.lastname: Hegemier
authors.forename: E O
authors.initials: EO
authors.lastname: Smith
authors.forename: W C
authors.initials: WC
authors.lastname: Heird
authors.forename: C J
authors.initials: CJ
authors.lastname: Fernandes
mesh_terms: D015415:Biomarkers / Q000097:blood / Q000652:urine*; D001724:Birth Weight; D001997:Bronchopulmonary Dysplasia / Q000175:diagnosis* / Q000652:urine; D015237:Dinoprost / Q000031:analogs & derivatives / Q000097:blood; D028441:F2-Isoprostanes / Q000652:urine*; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D007231:Infant, Newborn; D019102:Infant, Very Low Birth Weight; D008297:Male; D011237:Predictive Value of Tests; D011379:Prognosis; D012307:Risk Factors
chemical_list: D015415:Biomarkers; D028441:F2-Isoprostanes; C075750:8-epi-prostaglandin F2alpha; D015237:Dinoprost