title: Developing international consensus on measures of improvement for patients with myositis.
abstract: We discuss methods of developing consensus in measuring improvement in myositis. We consider selecting candidate variables, reliability and validity, percentage improvement/worsening rules, rules based on CART and logistic regression. We discuss criteria for determining an acceptable rule that include both numerical measures and physician acceptance.
authors.affiliation: FDA Center for Biologics Evaluation and Research, USA. lachenbruchpa@aol.com
authors.forename: Peter A
authors.initials: PA
authors.lastname: Lachenbruch
authors.forename: Frederick W
authors.initials: FW
authors.lastname: Miller
authors.forename: Lisa G
authors.initials: LG
authors.lastname: Rider
mesh_terms: D002986:Clinical Trials as Topic; D032921:Consensus; D006801:Humans; D007391:International Cooperation; D016015:Logistic Models; D009220:Myositis / Q000628:therapy*; D016896:Treatment Outcome