title: Electrochemical transfer of (18)F from (18)O water to aprotic polar solvent.
abstract: Electrochemical transfer of (18)F(-) from enriched [(18)O]-water to pure acetonitrile was investigated to develop a simple and effective synthesis of (18)F-radiopharmaceuticals. The transfer of (18)F is composed of two steps: first step is electro-deposition on a graphite anode and the next step is electro-emission into pure acetonitrile by inversing the polarity of the electric tension. A sufficiently high fraction of the electro-emission, 73%, was achieved. The electrochemical transfer of (18)F to aprotic polar solvents without any additives, such as phase transfer catalysis, will make the synthesis of diverse (18)F-radiopharamceuticals simple and easy.
authors.affiliation: Institute of Physics, Graduate School of Arts and Sciences, University of Tokyo, 3-8-1 Komaba, Meguro, Tokyo 153-8902, Japan. Fuminori@youshi.c.u-tokyo.ac.jp
authors.forename: Fuminori
authors.initials: F
authors.lastname: Saito
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Nagashima
authors.forename: Akira
authors.initials: A
authors.lastname: Goto
authors.forename: Masaya
authors.initials: M
authors.lastname: Iwaki
authors.forename: Nobukazu
authors.initials: N
authors.lastname: Takahashi
authors.forename: Takashi
authors.initials: T
authors.lastname: Oka
authors.forename: Tomio
authors.initials: T
authors.lastname: Inoue
authors.forename: Toshio
authors.initials: T
authors.lastname: Hyodo
mesh_terms: D000097:Acetonitriles / Q000737:chemistry*; D005462:Fluorine Radioisotopes / Q000737:chemistry*; D010103:Oxygen Isotopes / Q000737:chemistry; D019275:Radiopharmaceuticals / Q000138:chemical synthesis*; D014867:Water / Q000737:chemistry*
chemical_list: D000097:Acetonitriles; D005462:Fluorine Radioisotopes; D010103:Oxygen Isotopes; D019275:Radiopharmaceuticals; D014867:Water; C032159:acetonitrile