Decoding higher-order motor information from primate non-primary motor cortices.
To investigate the involvement of primate non-primary motor cortices in bimanual sequential movements, we recorded neuronal activity in the supplementary motor area (SMA) and presupplementary motor area (pre-SMA) while an animal was performing bimanual motor tasks that required two sequential arm movements consisting of either pronation or supination of the right or left arms with delay periods. We also recorded electromyograms (EMGs) from the arm while the animal performed the bimanual task to compare muscle and neuronal activity. This paper focuses on the neuronal activity before the onset of sequential movements. We found that the prime-mover forelimb muscles were selectively active when an impending arm movement involved recorded muscles, but was not dependent on whether the arm movements were bimanual or unimanual. In contrast, we found that neurons in the non-primary motor cortices showed different activity depending on whether the forthcoming sequential arm movements were unimanual or bimanual. Our results suggest that neuronal activity in the SMA and pre-SMA reflects higher-order information about arm use before motor execution. By extracting this type of information, we can use it to control prosthetic arms in a more intelligent manner through a brain-machine interface.
Nakajima
Toshi
T
Department of Physiology, Graduate School of Medicine, Tohoku University, Sendai, Miyagi, Japan. toxinak@mail.tains.tohoku.ac.jp
Mushiake
Hajime
H
Inui
Toshio
T
Tanji
Jun
J
D000818:Animals; D001698:Biomedical Engineering; D004576:Electromyography; D005542:Forearm / Q000294:innervation / Q000502:physiology; D005625:Frontal Lobe / Q000502:physiology*; D008251:Macaca / Q000502:physiology; D008297:Male; D008568:Memory / Q000502:physiology; D023421:Models, Animal; D009048:Motor Skills / Q000502:physiology*; D018482:Muscle, Skeletal / Q000294:innervation / Q000502:physiology; D009474:Neurons / Q000502:physiology*; D011597:Psychomotor Performance; D011897:Random Allocation