title: Efficacy of fenbendazole and milbemycin oxime for treating baboons (Papio cynocephalus anubis) infected with Trichuris trichiura.
abstract: We evaluated the efficacy of fenbendazole (FBZ) and milbemycin oxime (MO) in the treatment of baboons (Papio cynocephalus anubis) with naturally acquired Trichuris trichiura infection by comparing fecal egg count reduction (FECR) tests. We assigned 7 baboons, each singly housed and confirmed infected with T. trichiura, to treatment groups of FBZ (n=3) or MO (n=3), or as a control (n=1). All (100%) baboons that received FBZ stopped shedding T. trichiura eggs within 6 d of treatment, and fecal egg counts remained negative at 65 d after treatment. Although the number of T. trichiura eggs shed per gram of feces from 2 (67%) baboons decreased significantly after the second treatment with MO, this regimen never totally eliminated eggs of T. trichiura. The results of our study indicate that FBZ was more effective for treating baboons with T. trichiura than was MO.
authors.affiliation: Department of Veterinary Pathobiology, Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, USA. mason.reichard@okstate.edu
authors.forename: Mason V
authors.initials: MV
authors.lastname: Reichard
authors.forename: Roman F
authors.initials: RF
authors.lastname: Wolf
authors.forename: David W
authors.initials: DW
authors.lastname: Carey
authors.forename: Jennifer Jane
authors.initials: JJ
authors.lastname: Garrett
authors.forename: Heather A
authors.initials: HA
authors.lastname: Briscoe
mesh_terms: D000818:Animals; D000969:Antinematodal Agents / Q000627:therapeutic use*; D005273:Fenbendazole / Q000627:therapeutic use*; D018942:Macrolides / Q000627:therapeutic use*; D008992:Monkey Diseases / Q000188:drug therapy* / Q000469:parasitology; D048548:Papio cynocephalus / Q000469:parasitology*; D014257:Trichuriasis / Q000188:drug therapy / Q000662:veterinary*; D014258:Trichuris / Q000187:drug effects* / Q000502:physiology
chemical_list: D000969:Antinematodal Agents; D018942:Macrolides; C078973:milbemycin oxime; D005273:Fenbendazole