Striatal dopamine transporter binding in patients with Parkinson's disease and severe occupational hydrocarbon exposure.
We used 123I-Ioflupane SPECT to study striatal dopamine transporter (DAT) binding in 36 Parkinson's disease (PD) patients with history of severe occupational exposure to hydrocarbons. Data were compared with 38 PD patients without exposure history as well as healthy controls. Both PD cohorts showed significant striatal uptake decrements compared with controls. We found significantly lower values in the whole striatum of exposed compared with non-exposed patients (0.83 +/- 0.25 vs. 1.05 +/- 0.39; P = 0.004), more pronounced in the putamen (0.61 +/- 0.24 vs. 0.85 +/- 0.42; P = 0.004). We conclude that severe occupational exposure to hydrocarbons may modify disease course and ultimately accelerate nigro-striatal denervation.
Canesi
M
M
Parkinson Institute, Istituti Clinici di Perfezionamento, Milan, Italy. canesi@parkinson.it
Benti
R
R
Marotta
G
G
Cilia
R
R
Isaias
I U
IU
Gerundini
P
P
Pezzoli
G
G
Antonini
A
A
D000368:Aged; D001667:Binding, Competitive / Q000187:drug effects / Q000502:physiology; D003342:Corpus Striatum / Q000000981:diagnostic imaging / Q000187:drug effects / Q000378:metabolism*; D018450:Disease Progression; D004298:Dopamine / Q000378:metabolism; D050483:Dopamine Plasma Membrane Transport Proteins / Q000187:drug effects / Q000378:metabolism*; D005260:Female; D006801:Humans; D006838:Hydrocarbons / Q000633:toxicity*; D008297:Male; D008875:Middle Aged; D009410:Nerve Degeneration / Q000139:chemically induced / Q000378:metabolism / Q000503:physiopathology; D009662:Nortropanes / Q000493:pharmacokinetics; D016273:Occupational Exposure; D010300:Parkinson Disease / Q000175:diagnosis* / Q000209:etiology* / Q000503:physiopathology; D015899:Tomography, Emission-Computed, Single-Photon
D050483:Dopamine Plasma Membrane Transport Proteins; D006838:Hydrocarbons; D009662:Nortropanes; C519528:ioflupane; D004298:Dopamine