title: Preoperative localization of parathyroid adenoma with sonography and 99mTc-sestamibi scintigraphy in primary hyperparathyroidism.
abstract: OBJECTIVE
  To evaluate the sensitivity, specificity, and usefulness of dual-phase 99mTc-Sestamibi scintigraphy (SS) and sonography (US) of the neck, alone and in combination, as noninvasive adenoma localizing procedures in patients with primary hyperparathyroidism prior to parathyroidectomy.
  
  
  METHODS
  We retrospectively analyzed the charts of 79 patients with parathyroid (PT) adenomas and confirmed diagnosis of hyperparathyroidism who were evaluated with SS and US prior to successful parathyroidectomy.
  
  
  RESULTS
  Ninety-three adenomas were removed during bilateral neck exploration. SS alone showed a sensitivity of 76% and a specificity of 79% compared with 89% and 75%, respectively, for US performed after SS on the same day. Combination of the 2 procedures yielded a sensitivity of 89% and a specificity of 90%, with 22% discordant results. The differences in sensitivity and specificity between the 2 techniques alone or in combination were not statistically significant.
  
  
  CONCLUSIONS
  No benefit was gained from using both SS and US for the preoperative localization of PT adenomas in patients with primary hyperparathyroidism. Each technique can be negatively affected by thyroid enlargement and nodularity. US, when performed by a skilled operator, is a reliable tool for PT adenoma localization. If the US findings are inconclusive, SS should be used.
authors.affiliation: Department of Internal Medicine, University of Torino, Torino 10126, Italy.
authors.forename: Ilaria
authors.initials: I
authors.lastname: Grosso
authors.forename: Antonella
authors.initials: A
authors.lastname: Sargiotto
authors.forename: Patrizia
authors.initials: P
authors.lastname: D'Amelio
authors.forename: Cristina
authors.initials: C
authors.lastname: Tamone
authors.forename: Guido
authors.initials: G
authors.lastname: Gasparri
authors.forename: Pier Giuseppe
authors.initials: PG
authors.lastname: De Filippi
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Picciotto
authors.forename: Giancarlo
authors.initials: G
authors.lastname: Isaia
mesh_terms: D000236:Adenoma / Q000000981:diagnostic imaging*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D049950:Hyperparathyroidism, Primary / Q000000981:diagnostic imaging*; D007430:Intraoperative Care; D008297:Male; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000032:analysis; D010282:Parathyroid Neoplasms / Q000000981:diagnostic imaging*; D016105:Parathyroidectomy; D011183:Postoperative Complications; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D012009:Recurrent Laryngeal Nerve / Q000503:physiopathology; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D017256:Technetium Tc 99m Sestamibi; D013961:Thyroid Gland / Q000000981:diagnostic imaging; D016606:Thyroid Nodule / Q000000981:diagnostic imaging; D014463:Ultrasonography; D014826:Vocal Cord Paralysis / Q000209:etiology
chemical_list: D010281:Parathyroid Hormone; D019275:Radiopharmaceuticals; D017256:Technetium Tc 99m Sestamibi