title: Use of background inorganic arsenic exposures to provide perspective on risk assessment results.
abstract: Background exposures provide perspective for interpreting calculated health risks associated with naturally occurring substances such as arsenic. Background inorganic arsenic intake from diet and water for children (ages 1-6 years) and all ages of the U.S. population was modeled stochastically using consumption data from USDA, published data on inorganic arsenic in foods, and EPA data on arsenic in drinking water. Mean and 90th percentile intakes for the U.S. population were 5.6 and 10.5 microg/day, assuming nationwide compliance with the 10 microg/L U.S. drinking water standard. Intakes for children were slightly lower (3.5 and 5.9 microg/day). Based on the current EPA cancer slope factor for arsenic, estimated lifetime risks associated with background diet and water at the mean and 90th percentile are 1 per 10,000 and 2 per 10,000, respectively. By comparison, reasonable maximum risks for arsenic in soil at 20 (higher typical background level) and 100mg/kg are 4 per 100,000 and 2 per 10,000, using EPA default exposure assumptions. EPA reasonable maximum estimates of arsenic exposure from residential use of treated wood are likewise within background intakes. These examples provide context on how predicted risks compare to typical exposures within the U.S. population, thereby providing perspective for risk communication and regulatory decision-making on arsenic in the environment and in consumer products.
authors.affiliation: Exponent, 15375 SE 30th Place, Suite 250, Bellevue, WA 98007, USA. tsujij@exponent.com <tsujij@exponent.com>
authors.forename: Joyce S
authors.initials: JS
authors.lastname: Tsuji
authors.forename: Lisa J
authors.initials: LJ
authors.lastname: Yost
authors.forename: Leila M
authors.initials: LM
authors.lastname: Barraj
authors.forename: Carolyn G
authors.initials: CG
authors.lastname: Scrafford
authors.forename: Pamela J
authors.initials: PJ
authors.lastname: Mink
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001151:Arsenic / Q000032:analysis*; D020261:Arsenic Poisoning; D002648:Child; D002675:Child, Preschool; D004781:Environmental Exposure / Q000032:analysis*; D005506:Food Contamination; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008875:Middle Aged; D018570:Risk Assessment; D012989:Soil Pollutants; D014481:United States; D014874:Water Pollutants, Chemical; D014934:Wood / Q000633:toxicity
chemical_list: D012989:Soil Pollutants; D014874:Water Pollutants, Chemical; D001151:Arsenic