title: Cytokines and chemokines shaping the B-cell compartment.
abstract: The whole life of a B-cell from a stem cell to a mature plasma cell is governed, among other factors, by cytokines and growth factors in their microenvironment. Remarkable progress in the understanding of the mechanisms of cytokines action on the B-cell compartment was achieved by analysis of gene-targeted mice. The generation of mice deficient for individual cytokines or their receptors has shed light on the in vivo function of cytokines in B-cell responses. This review focuses on the role of cytokines in the development, maturation and differentiation of different B-cell subsets into antibody-secreting cells or memory B-cells.
authors.affiliation: Department of Clinical Biochemistry, School of Chemical Sciences, National University of Córdoba, Córdoba, Argentina.
authors.forename: Eva V
authors.initials: EV
authors.lastname: Acosta-Rodríguez
authors.forename: Maria C
authors.initials: MC
authors.lastname: Merino
authors.forename: Carolina L
authors.initials: CL
authors.lastname: Montes
authors.forename: C Cristina
authors.initials: CC
authors.lastname: Motrán
authors.forename: Adriana
authors.initials: A
authors.lastname: Gruppi
mesh_terms: D000818:Animals; D016175:B-Lymphocyte Subsets / Q000276:immunology*; D002454:Cell Differentiation / Q000276:immunology*; D018925:Chemokines / Q000276:immunology*; D016207:Cytokines / Q000276:immunology*; D006412:Hematopoietic Stem Cells / Q000276:immunology*; D006801:Humans; D007156:Immunologic Memory; D010950:Plasma Cells / Q000276:immunology*
chemical_list: D018925:Chemokines; D016207:Cytokines