Mesoporous silicon: a platform for the delivery of therapeutics.
Nanostructuring materials can radically change their properties. Two interesting examples highlighted here are nanoscale porosity inducing biodegradability, and nanoscale confinement affecting the physical form of an entrapped drug. Mesoporous silicon is under increasing study for drug-delivery applications, and is the topic of this review. The authors focus on those properties of most relevance to this application, as well as those recent studies published on small molecule and peptide/protein delivery.
Prestidge
Clive A
CA
University of South Australia, Ian Wark Research Institute, Australia.
Barnes
Timothy J
TJ
Lau
Chi-Hian
CH
Barnett
Christian
C
Loni
Armando
A
Canham
Leigh
L
D002626:Chemistry, Pharmaceutical; D004339:Drug Compounding / Q000379:methods; D016503:Drug Delivery Systems / Q000379:methods*; D008422:Materials Testing; D049329:Nanostructures / Q000737:chemistry*; D036103:Nanotechnology / Q000379:methods*; D010455:Peptides; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D016062:Porosity; D011506:Proteins; D012666:Semiconductors; D012825:Silicon / Q000737:chemistry*
D010455:Peptides; D004364:Pharmaceutical Preparations; D011506:Proteins; D012825:Silicon