title: Palliative intravenous cisplatin treatment for concurrent peritoneal and pleural mesothelioma in a dog.
abstract: A 10-year-old Maltese dog was presented with abdominal distention and dyspnea. Cytological examination of pleural and peritoneal effusion was suggestive of malignant effusion of glandular origin. Numerous, multifocal, tan to white nodules were disseminated throughout the surface of the abdominal organs and peritoneum at biopsy. Histologically, the tumors were revealed to be an epithelial type of mesothelioma. Neoplastic cells co-expressed cytokeratin and vimentin. Intravenous administration of cisplatin was chosen as the treatment. During treatment, the dog's overall body condition improved and the clinical signs were relieved without significant side effects. The survival time from diagnosis to sudden death by unknown cause was 153 days.
authors.affiliation: Department of Veterinary Internal Medicine, College of Veterinary Medicine, Seoul National University, Korea.
authors.forename: Kyoung-Won
authors.initials: KW
authors.lastname: Seo
authors.forename: Ul-Soo
authors.initials: US
authors.lastname: Choi
authors.forename: Yun-Chan
authors.initials: YC
authors.lastname: Jung
authors.forename: Su-Ji
authors.initials: SJ
authors.lastname: Hong
authors.forename: Ye-Eun
authors.initials: YE
authors.lastname: Byeun
authors.forename: Min-Soo
authors.initials: MS
authors.lastname: Kang
authors.forename: B
authors.initials: B
authors.lastname: Pachrin
authors.forename: Wan-Hee
authors.initials: WH
authors.lastname: Kim
authors.forename: Cheol-Yong
authors.initials: CY
authors.lastname: Hwang
authors.forename: Dae-Yong
authors.initials: DY
authors.lastname: Kim
authors.forename: Hwa-Young
authors.initials: HY
authors.lastname: Youn
authors.forename: Chang-Woo
authors.initials: CW
authors.lastname: Lee
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002945:Cisplatin / Q000627:therapeutic use*; D004283:Dog Diseases / Q000188:drug therapy* / Q000473:pathology; D004285:Dogs; D017809:Fatal Outcome; D005260:Female; D006651:Histocytochemistry / Q000662:veterinary; D008654:Mesothelioma / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D010534:Peritoneal Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D010997:Pleural Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*
chemical_list: D000970:Antineoplastic Agents; D002945:Cisplatin