Electrochemical transfer of (18)F from (18)O water to aprotic polar solvent.
Electrochemical transfer of (18)F(-) from enriched [(18)O]-water to pure acetonitrile was investigated to develop a simple and effective synthesis of (18)F-radiopharmaceuticals. The transfer of (18)F is composed of two steps: first step is electro-deposition on a graphite anode and the next step is electro-emission into pure acetonitrile by inversing the polarity of the electric tension. A sufficiently high fraction of the electro-emission, 73%, was achieved. The electrochemical transfer of (18)F to aprotic polar solvents without any additives, such as phase transfer catalysis, will make the synthesis of diverse (18)F-radiopharamceuticals simple and easy.
Saito
Fuminori
F
Institute of Physics, Graduate School of Arts and Sciences, University of Tokyo, 3-8-1 Komaba, Meguro, Tokyo 153-8902, Japan. Fuminori@youshi.c.u-tokyo.ac.jp
Nagashima
Yasuyuki
Y
Goto
Akira
A
Iwaki
Masaya
M
Takahashi
Nobukazu
N
Oka
Takashi
T
Inoue
Tomio
T
Hyodo
Toshio
T
D000097:Acetonitriles / Q000737:chemistry*; D005462:Fluorine Radioisotopes / Q000737:chemistry*; D010103:Oxygen Isotopes / Q000737:chemistry; D019275:Radiopharmaceuticals / Q000138:chemical synthesis*; D014867:Water / Q000737:chemistry*
D000097:Acetonitriles; D005462:Fluorine Radioisotopes; D010103:Oxygen Isotopes; D019275:Radiopharmaceuticals; D014867:Water; C032159:acetonitrile