Trace measurement of phenothiazine drugs in tablets by micellar-enhanced fluorophotometric method.
It was found that in buffer solution of pH 7.0, the addition of sodium dodecyl sulfate (SDS) to the solution of phenothiazine drugs, such as chlorpromazine, promethazine and trifluoperazine, showed a remarkable enhancement of their fluorescence intensity. A further study proved that the phenothiazine drugs can be determined by fluorophotometric method in micellar system. Under optimal conditions, there was a good linear relationship between fluorescence intensity and phenothiazine compounds concentration, and the detection limit of 3.0 x 10(-8) M chlorpromazine, 3.0 x 10(-8) M promethazine and 1.5 x 10(-8) M trifluoperazine (S/N=3) were also obtained. This method has been used to determine phenothiazine drugs in tablets with satisfactory results.
Yang
Gong-Jun
GJ
College of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, PR China. yanggongjun888@163.com
Qu
Xi-Long
XL
Shen
Ming
M
Qu
Qi-Shu
QS
Wang
Chen-Ying
CY
Zhu
Ai-Ping
AP
Hu
Xiao-Ya
XY
D015590:Fluorophotometry / Q000379:methods*; D008823:Micelles; D010640:Phenothiazines / Q000032:analysis*; D012967:Sodium Dodecyl Sulfate / Q000737:chemistry; D013607:Tablets
D008823:Micelles; D010640:Phenothiazines; D013607:Tablets; D012967:Sodium Dodecyl Sulfate