No evidence for involvement of prothrombotic platelet receptor polymorphisms in acute coronary stent thrombosis.
Polymorphisms of receptors involved in platelet adhesion and aggregation modulate platelet thrombogenicity and were found to predispose to premature arterial thromboses in individuals at risk. In our current study, we assessed the potential relevance of prothrombotic platelet receptor polymorphisms for the pathogenesis of acute coronary stent thrombosis. Comparing the genotype prevalences of respective polymorphisms in patients with acute coronary stent thrombosis and healthy control subjects, our data do not indicate an increased risk of carriers of prothrombotic variants of platelet receptors for this complication. Other factors such as the remodelling process and antiplatelet medication appear to be more relevant in this clinical setting. Along with our findings, screening for respective polymorphisms for risk assessment prior to coronary stenting is not indicated.
Sucker
Christoph
C
Scheffold
Norbert
N
Cyran
Joachim
J
Ghodsizad
Ali
A
Scharf
Ruediger E
RE
Zotz
Rainer B
RB
D000208:Acute Disease; D000368:Aged; D015906:Angioplasty, Balloon, Coronary / Q000009:adverse effects* / Q000379:methods; D015331:Cohort Studies; D023903:Coronary Restenosis / Q000453:epidemiology / Q000235:genetics; D023921:Coronary Stenosis / Q000628:therapy; D003328:Coronary Thrombosis / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D005500:Follow-Up Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000235:genetics*; D011110:Polymorphism, Genetic; D011475:Prosthesis Failure; D012016:Reference Values; D012680:Sensitivity and Specificity; D015607:Stents / Q000009:adverse effects*
D019039:Platelet Glycoprotein GPIIb-IIIa Complex