Demographic and clinical characteristics associated with treatment status in family members with obsessive-compulsive disorder.
This study investigated the demographic and clinical factors that influence treatment status in family members with obsessive compulsive disorder (OCD). Six hundred and two subjects from the OCD Collaborative Genetics Study were interviewed using the Structured Clinical Interview for DSM-IV (SCID) to diagnose Axis I disorders, and the Yale-Brown Obsessive Compulsive Scale (Y-BOCS) for assessment of OCD symptoms. The demographic and clinical data were compared between subjects who had received treatment and those who had not. A precipitous onset of symptoms, severe illness, multiple obsessions and compulsions, and co-morbid affective disorders were all positively associated with receiving treatment. Older age and the presence of obsessive compulsive personality disorder (OCPD) or OCPD traits were negatively associated with treatment. Gender and age at onset of symptoms did not predict treatment history. The mean duration from onset of symptoms to receiving treatment was 13.8+/-SD 11.9 years, but there was a direct relationship between current age and time to treatment, with younger subjects receiving treatment sooner. Clinical factors are predominant in predicting treatment status in family members with OCD. Although the mean duration from onset of symptoms to treatment was long, younger family members appear to receive treatment sooner.
Cullen
Bernadette
B
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA. bcullen@jhmi.edu
Samuels
Jack F
JF
Pinto
Anthony
A
Fyer
Abby J
AJ
McCracken
James T
JT
Rauch
Scott L
SL
Murphy
Dennis L
DL
Greenberg
Benjamin D
BD
Knowles
James A
JA
Piacentini
John
J
Bienvenu
O Joseph
OJ
Grados
Marco A
MA
Riddle
Mark A
MA
Rasmussen
Steven A
SA
Pauls
David L
DL
Willour
Virginia L
VL
Shugart
Yin Y
YY
Liang
Kung-Yee
KY
Hoehn-Saric
Rudolf
R
Nestadt
Gerald
G
D000328:Adult; D000367:Age Factors; D017668:Age of Onset; D001294:Attitude to Health; D015897:Comorbidity; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D006304:Health Status; D006801:Humans; D016015:Logistic Models; D008297:Male; D019964:Mood Disorders / Q000175:diagnosis / Q000453:epidemiology; D009771:Obsessive-Compulsive Disorder / Q000175:diagnosis* / Q000453:epidemiology / Q000628:therapy*; D010342:Patient Acceptance of Health Care; D010555:Personality Inventory; D011569:Psychiatric Status Rating Scales; D012737:Sex Factors; D013997:Time Factors