title: An audit of clinically relevant abnormal laboratory parameters investigating athletes with persistent symptoms of fatigue.
abstract: The aim of this audit was to assess the yield of a selection of laboratory tests as part of the clinical assessment of the fatigued athlete. Clinical charts and blood test results of fifty consecutive athletes who presented with the primary complaint of fatigue were retrospectively reviewed. Blood tests results reviewed were: haematology (haemoglobin, red cell count, mean cell volume, mean cell haemoglobin content, platelets, white cell count, differential white cell count); erythrocyte sedimentation rate; serum biochemistry (urea, creatinine, electrolytes, urate, glucose, liver function tests, albumin, globulin); blood iron status (serum iron, total iron binding capacity, percent transferring saturation, and ferritin concentration); thyroid stimulating hormone; and immune measures (Epstein-Barr virus serology, cytomegalovirus serology). We identified only 3 abnormal results that contributed to the diagnosis of medical disease as a cause for fatigue. Laboratory testing identified 2 fatigued female athletes with serum ferritin concentration between 15 microg L(-1) and 20 microg L(-1) plus two of the other criteria of iron concentration (serum iron <10 micromol L(-1), iron binding capacity > 68 micromol L(-1), or transferrin saturation <15%). We concluded that the yield from a selection of blood tests investigating fatigued athletes was low. Future study is needed to further define the role of laboratory testing and to study whether low iron stores in the absence of anaemia is related to symptoms in fatigued athletes.
authors.affiliation: Greenslopes Centre for Sport and Movement, Queensland, Australia. neelsils@bigpond.com
authors.forename: Cornelius
authors.initials: C
authors.lastname: Du Toit
authors.forename: Simon
authors.initials: S
authors.lastname: Locke
mesh_terms: D000293:Adolescent; D000328:Adult; D001772:Blood Cell Count; D001799:Blood Sedimentation; D017079:Exercise Tolerance / Q000502:physiology*; D005221:Fatigue / Q000097:blood*; D005260:Female; D005293:Ferritins / Q000097:blood; D006801:Humans; D008297:Male; D012189:Retrospective Studies; D013177:Sports / Q000502:physiology*; D013960:Thyroid Function Tests
chemical_list: D005293:Ferritins