Efficacy of tonsillectomy plus methylprednisolone pulse therapy for a child with Henoch-Schoenlein purpura nephritis.
Henoch-Schoenlein purpura (HSP) is a systemic disorder characterized by a leukocytoplastic vasculitis involving small vessels with the deposition of immunoglobulin A (IgA) immune complexes. Renal involvement is the principal cause of morbidity and mortality in children with HSP. We report here an 11-year-old boy with Henoch-Schoenlein purpura nephritis (HSPN) accompanied by recurrent purpura and persistent nephropathy despite conventional therapy such as prednisolone, methylprednisolone pulse therapy and immunosuppressive agent (Mizoribine). The patient was treated with tonsillectomy plus methylprednisolone pulse therapy. This treatment decreased proteinuria, induced disappearance of microscopic hematuria, and improved renal pathological findings. Tonsillectomy plus methylprednisolone pulse is effective and useful therapy for some children with recurrent purpura and persistent nephropathy.
Kawasaki
Yukihiko
Y
Department of Pediatrics, Fukushima Medical University School of Medicine, Japan. tomo@fmu.ac.jp
Suyama
Kazuhide
K
Matsumoto
Ayumi
A
Takano
Kei
K
Hashimoto
Koichi
K
Suzuki
Sigeo
S
Suzuki
Junzo
J
Suzuki
Hitoshi
H
Hosoya
Mitsuaki
M
D002648:Child; D006801:Humans; D011695:IgA Vasculitis / Q000188:drug therapy* / Q000601:surgery*; D007668:Kidney / Q000473:pathology; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage* / Q000627:therapeutic use*; D020551:Pulse Therapy, Drug; D014068:Tonsillectomy
D008775:Methylprednisolone