Microevolution in genomic short sequence repeats of Candida albicans in non-neutropenic patients.
The genome of the yeast Candida albicans harbours many genomic short sequence repeats (SSRs). These are stable upon transition of colonization to infection in immune-compromised patients. We show here that in non-neutropenic patients this transition may coincide with variation in several of the SSRs. This may have implications for stage-specific expression of C. albicans pathogenicity factors.
Al-Aidan
Al Waleed
AW
King Faysal Hospital and Research Centre, Department of Microbiology and Hospital Hygiene, Riyadh, Saudi Arabia.
Goessens
Wil
W
Lemmens-den Toom
Nicole
N
Al-Ahdal
Mohammed
M
van Belkum
Alex
A
D002176:Candida albicans / Q000235:genetics* / Q000302:isolation & purification; D002177:Candidiasis / Q000209:etiology / Q000235:genetics / Q000382:microbiology; D004271:DNA, Fungal / Q000235:genetics*; D004636:Emergency Service, Hospital; D019143:Evolution, Molecular; D014644:Genetic Variation; D006801:Humans; D019105:Random Amplified Polymorphic DNA Technique; D012091:Repetitive Sequences, Nucleic Acid; D014947:Wounds and Injuries / Q000150:complications
D004271:DNA, Fungal