title: Synapse-specific reconsolidation of distinct fear memories in the lateral amygdala.
abstract: When reactivated, memories enter a labile, protein synthesis-dependent state, a process referred to as reconsolidation. Here, we show in rats that fear memory retrieval produces a synaptic potentiation in the lateral amygdala that is selective to the reactivated memory, and that disruption of reconsolidation is correlated with a reduction of synaptic potentiation in the lateral amygdala. Thus, both retrieval and reconsolidation alter memories via synaptic plasticity at selectively targeted synapses.
authors.affiliation: Neurobiologie de l'Apprentissage, de la Mémoire et de la Communication (NAMC), Centre National de la Recherche Scientifique (CNRS), UMR8620, Université Paris-Sud, 91405 Orsay, France.
authors.forename: Valérie
authors.initials: V
authors.lastname: Doyère
authors.forename: Jacek
authors.initials: J
authors.lastname: Debiec
authors.forename: Marie-H
authors.initials: MH
authors.lastname: Monfils
authors.forename: Glenn E
authors.initials: GE
authors.lastname: Schafe
authors.forename: Joseph E
authors.initials: JE
authors.lastname: LeDoux
mesh_terms: D000161:Acoustic Stimulation / Q000379:methods; D000679:Amygdala / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D000704:Analysis of Variance; D000818:Animals; D001522:Behavior, Animal; D002070:Butadienes / Q000494:pharmacology; D003214:Conditioning, Classical / Q000187:drug effects / Q000502:physiology*; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005239:Fear; D008297:Male; D008568:Memory / Q000187:drug effects / Q000502:physiology*; D009570:Nitriles / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D011930:Reaction Time / Q000502:physiology / Q000528:radiation effects; D013569:Synapses / Q000187:drug effects / Q000502:physiology*
chemical_list: D002070:Butadienes; D004791:Enzyme Inhibitors; D009570:Nitriles; C113580:U 0126