title: [A case of advanced clear cell carcinoma of the endometrium that responded remarkably to neoadjuvant chemotherapy of combination carboplatin plus weekly paclitaxel].
abstract: Clear cell carcinoma of the endometrium is a very rare and highly malignant neoplasm that accounts for less than 5% of endometrial carcinoma. Survival of patients in the advanced stage is poor, and the treatment of choice is not clear. We report the case of a 62-year-old woman who had Stage IVb advanced clear cell carcinoma of the endometrium with multiple lung metastases. The lesions were considered surgically incurable, so she was placed on neoadjuvant chemotherapy of combination carboplatin (CBDCA) (AUC 5, day 1) plus weekly paclitaxel (PTX) (70 mg/m(2), day 1, 8, 15). After 3 courses of chemotherapy, the uterine tumor was obviously reduced, and lung metastases had disappeared. Therefore, she underwent the operation. The current case suggests that combination CBDCA plus weekly PTX is effective against advanced clear cell carcinoma of the endometrium.
authors.affiliation: Dept. of Obstetrics and Gynecology, Kasukabe Municipal General Hospital.
authors.forename: Masashi
authors.initials: M
authors.lastname: Takami
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Ohta
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Nakayama
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Fukai
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Matsumoto
authors.forename: Toshiro
authors.initials: T
authors.lastname: Takimoto
authors.forename: Hideki
authors.initials: H
authors.lastname: Sakamoto
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Yamamoto
mesh_terms: D018262:Adenocarcinoma, Clear Cell / Q000188:drug therapy* / Q000556:secondary / Q000601:surgery; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D016190:Carboplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D004334:Drug Administration Schedule; D016889:Endometrial Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D020883:Hysterotomy; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000556:secondary*; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D009367:Neoplasm Staging; D017239:Paclitaxel / Q000008:administration & dosage; D012074:Remission Induction
chemical_list: D016190:Carboplatin; D017239:Paclitaxel