Renal response to repeated exposure to endotoxin: implications for acute kidney injury.
Zager and colleagues demonstrate that endotoxin tolerance is accompanied by an augmented inflammatory response in the kidney, the latter also exhibiting cholesterol-dependent cytoresistance. These novel findings are discussed mainly from the perspective of acute kidney injury and its prevention by preconditioning and the elicitation of cytoprotective pathways.
Nath
K A
KA
Division of Nephrology and Hypertension, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA. nath.karl@mayo.edu
D000208:Acute Disease; D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D002784:Cholesterol / Q000502:physiology; D019610:Cytoprotection / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D004361:Drug Tolerance / Q000502:physiology; D004731:Endotoxins / Q000009:adverse effects* / Q000494:pharmacology; D007249:Inflammation / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control; D019194:Ischemic Preconditioning; D007668:Kidney / Q000187:drug effects / Q000503:physiopathology*; D007674:Kidney Diseases / Q000209:etiology* / Q000503:physiopathology* / Q000517:prevention & control; D008070:Lipopolysaccharides / Q000009:adverse effects* / Q000494:pharmacology; D008297:Male; D051379:Mice; D014661:Vasoconstriction / Q000187:drug effects
D004731:Endotoxins; D008070:Lipopolysaccharides; D002784:Cholesterol