title: A simple method for measuring long-range 1H-13C coupling constants in organic molecules.
abstract: This study presents a simple method for measuring long-range heteronuclear coupling constants between protons and proton-bearing carbons. The approach involves recording two conventional 1D-TOCSY experiments in which the offset of the selective proton pulse is set on the low- and high-frequency 13C satellites of an isolated proton signal, Hi. Long-range heteronuclear coupling values between the 13Ci bonded to Hi and the protons Hj,k...n that belong to the same spin system were easily determined from the relative displacement of the relayed Hj,k...n signals in the satellite-selective TOCSY spectra. The sense of the displacement indicated the sign of the coupling constants.
authors.affiliation: Discovery Chemistry Research & Technologies, Lilly Research Laboratories, Centro de Investigación Lilly, Avenida de la Industria 30, 28108 Alcobendas, Madrid, Spain.
authors.forename: Paloma
authors.initials: P
authors.lastname: Vidal
authors.forename: Nuria
authors.initials: N
authors.lastname: Esturau
authors.forename: Teodor
authors.initials: T
authors.lastname: Parella
authors.forename: Juan F
authors.initials: JF
authors.lastname: Espinosa
mesh_terms: D002244:Carbon / Q000737:chemistry; D006859:Hydrogen / Q000737:chemistry; D007532:Isoleucine / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008610:Menthol / Q000737:chemistry; D009930:Organic Chemicals / Q000737:chemistry*; D011522:Protons; D013267:Stilbenes / Q000737:chemistry
chemical_list: D009930:Organic Chemicals; D011522:Protons; D013267:Stilbenes; D007532:Isoleucine; D008610:Menthol; D002244:Carbon; D006859:Hydrogen; C025906:stilbene oxide