title: Polypeptide growth factors in gastroenteropancreatic neuroendocrine tumours.
abstract: Polypeptide growth factors form a potent class of extracellular signal molecules in the regulation of cellular differentiation and proliferation. Disturbances in the expression of growth factors influence the normal pathway of differentiation and lead to cellular transformation and tumour progression. Contemporary medical studies report that various growth factors such as those for platelet-derived growth factor, vascular endothelial growth factor, epidermal growth factor, hepatocyte growth factor and insulin-like growth factor are expressed in gastroenteropancreatic neuroendocrine tumours (GEP/NET). Polypeptide growth factors have great significance in the growth, progression and development of metastases by various tumours. We describe the role of growth factors in GEP/NET on the basis of the available reports of medical research.
authors.affiliation: Division of Endocrinology, Department of Pathophysiology and Endocrinology, Medical University of Silesia, Zabrze.
authors.forename: Jolanta
authors.initials: J
authors.lastname: Blicharz-Dorniak
authors.forename: Beata
authors.initials: B
authors.lastname: Kos-Kudła
authors.forename: Marek
authors.initials: M
authors.lastname: Kudła
authors.forename: Wanda
authors.initials: W
authors.lastname: Foltyn
authors.forename: Bogdan
authors.initials: B
authors.lastname: Marek
authors.forename: Lucyna
authors.initials: L
authors.lastname: Siemińska
authors.forename: Mariusz
authors.initials: M
authors.lastname: Nowak
mesh_terms: D004815:Epidermal Growth Factor / Q000378:metabolism; D005346:Fibroblast Growth Factors / Q000378:metabolism; D005770:Gastrointestinal Neoplasms / Q000378:metabolism*; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism*; D018358:Neuroendocrine Tumors / Q000378:metabolism*; D039943:Neuropilin-2 / Q000378:metabolism; D010190:Pancreatic Neoplasms / Q000378:metabolism*; D010982:Platelet-Derived Growth Factor / Q000378:metabolism; D016211:Transforming Growth Factor alpha / Q000378:metabolism; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism
chemical_list: D036341:Intercellular Signaling Peptides and Proteins; D039943:Neuropilin-2; D010982:Platelet-Derived Growth Factor; D016211:Transforming Growth Factor alpha; D042461:Vascular Endothelial Growth Factor A; D005346:Fibroblast Growth Factors; D004815:Epidermal Growth Factor; D007334:Insulin-Like Growth Factor I