title: Plasmodium yoelii: influence of antimalarial treatment on acquisition of immunity in BALB/c and DBA/2 mice.
abstract: The effect of antimalarial drugs on immune responses to the malaria infection is evaluated in vivo using two experimental self-cured rodent models. BALB/c and DBA/2 mice were infected by Plasmodium yoelii 17XNL and 17XL strains, respectively, and then treated with different doses of antimalarial drugs: chloroquine (228mg/kg or 114mg/kg of the body weight) or artesunate (78mg/kg or 39mg/kg). The effect of antimalarial drugs on host immune responses was evaluated by parasitemia, splenocyte IFN-gamma production level, and parasite-specific IgG level in the serum, however, no significant differences were observed between drug-treated and untreated groups. Moreover, most of the infected mice of all groups showed the ability to resist homologous reinfection (challenged on day 60 post-infection), only a few mice experienced transient, low parasitemia. The rechallenged mice were accompanied by high level of parasite-specific IgG. Therefore, this research implicated that, for BALB/c and DBA/2 mice, chloroquine or artesunate treatment of blood-stage P. yoelii infections does not compromise acquired immunity to malaria in either primary infection or upon rechallenge.
authors.affiliation: Department of Immunology, College of Basic Medical Sciences, China Medical University, Heping District, Shenyang, China.
authors.forename: Shi-Hong
authors.initials: SH
authors.lastname: Ma
authors.forename: Li
authors.initials: L
authors.lastname: Zheng
authors.forename: Ying-Jie
authors.initials: YJ
authors.lastname: Liu
authors.forename: Sheng-Yu
authors.initials: SY
authors.lastname: Guo
authors.forename: Hui
authors.initials: H
authors.lastname: Feng
authors.forename: Guang
authors.initials: G
authors.lastname: Chen
authors.forename: Dong-Mei
authors.initials: DM
authors.lastname: Li
authors.forename: Ji-Chun
authors.initials: JC
authors.lastname: Wang
authors.forename: Ya-Ming
authors.initials: YM
authors.lastname: Cao
mesh_terms: D000818:Animals; D000913:Antibodies, Protozoan / Q000096:biosynthesis / Q000097:blood; D000962:Antimalarials / Q000494:pharmacology*; D037621:Artemisinins / Q000494:pharmacology*; D000077332:Artesunate; D002738:Chloroquine / Q000494:pharmacology*; D005260:Female; D007074:Immunoglobulin G / Q000096:biosynthesis / Q000097:blood; D007371:Interferon-gamma / Q000032:analysis; D008288:Malaria / Q000188:drug therapy* / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D008811:Mice, Inbred DBA; D018512:Parasitemia / Q000188:drug therapy / Q000276:immunology / Q000469:parasitology; D010967:Plasmodium yoelii / Q000187:drug effects* / Q000276:immunology; D012008:Recurrence; D012717:Sesquiterpenes / Q000494:pharmacology*
chemical_list: D000913:Antibodies, Protozoan; D000962:Antimalarials; D037621:Artemisinins; D007074:Immunoglobulin G; D012717:Sesquiterpenes; D000077332:Artesunate; D007371:Interferon-gamma; D002738:Chloroquine