title: [Ibuprofen in childhood: evidence-based review of efficacy and safety].
abstract: Ibuprofen is the non-steroidal anti-inflammatory drug most prescribed for the treatment of fever and moderate pain in childhood. Its analgesic and antipyretic efficacy is now well documented: at equal doses ibuprofen appears slightly more effective than acetaminophen in the treatment of fever and is equivalent for analgesia. However, adverse effects should be taken into account in the choice between ibuprofen and acetaminophen. Lot of studies (case reports, cohort studies, case-control studies and one multicenter double-blind randomized control trial) have reported ibuprofen adverse effects at therapeutics doses. These data suggest there is an increased risk of invasive group A streptococcal infection after chickenpox and of acute renal failure in case of hypovolemia after a treatment by ibuprofen. Gastroduodenal and hemorrhagic adverse events could also happen, but the causality with ibuprofen is not demonstrated. Therefore, ibuprofen is not recommended for the treatment of fever or moderate pain during chickenpox or during a disease with a risk of dehydration, until other pharmacoepidemiology studies more accurately quantify the risk of adverse events of ibuprofen in children.
authors.affiliation: DES de Pédiatrie, Région Ile-de-France.
authors.forename: S
authors.initials: S
authors.lastname: Leroy
authors.forename: A
authors.initials: A
authors.lastname: Mosca
authors.forename: C
authors.initials: C
authors.lastname: Landre-Peigne
authors.forename: M-A
authors.initials: MA
authors.lastname: Cosson
authors.forename: G
authors.initials: G
authors.lastname: Pons
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology / Q000627:therapeutic use*; D001249:Asthma / Q000150:complications; D002644:Chickenpox / Q000150:complications; D002648:Child; D005767:Gastrointestinal Diseases / Q000139:chemically induced; D006801:Humans; D020896:Hypovolemia / Q000150:complications; D007052:Ibuprofen / Q000494:pharmacology / Q000627:therapeutic use*; D019106:Postoperative Hemorrhage / Q000139:chemically induced; D012449:Safety; D013290:Streptococcal Infections / Q000150:complications; D013297:Streptococcus pyogenes
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D007052:Ibuprofen