A rationally designed macrocyclic cavitand that kills bacteria with high efficacy and good selectivity.
An amphiphilic macrocyclic cavitand that shows good antibacterial activity, comparable to that of peptide-based antibiotics was developed by rational design and its antibacterial selectivity over mammalian cells was examined.
Choi
Jinny
J
Department of Life Science, Gwangju Institute of Science and Technology, Gwangju 500-712, Korea.
Kim
Jeeyeon
J
Kim
Kimoon
K
Yang
Sung-Tae
ST
Kim
Jae-Il
JI
Jon
Sangyong
S
D000818:Animals; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001952:Bridged-Ring Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D007093:Imidazoles / Q000737:chemistry; D047028:Macrocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D051379:Mice; D008826:Microbial Sensitivity Tests; D041681:NIH 3T3 Cells; D053835:Unilamellar Liposomes / Q000378:metabolism; D000099246:Cucurbit(n)urils
D000900:Anti-Bacterial Agents; D001952:Bridged-Ring Compounds; D007093:Imidazoles; D047028:Macrocyclic Compounds; D053835:Unilamellar Liposomes; C454805:cucurbit(6)uril; D000099246:Cucurbit(n)urils