Pharmacokinetics of intramuscular ketamine in young ostriches premedicated with romifidine.
Ketamine is a short-acting dissociative anaesthetic for chemical restraint and surgical anaesthesia in domestic and non-domestic animals. The present study was designed to determine the pharmacokinetics of a single dose of ketamine (10 mg/kg) after intramuscular (i.m.) administration to young ostriches premedicated with romifidine. Ketamine was rapidly absorbed after i.m. administration. Maximal ketamine concentration (C(max)) of 2.93 +/- 0.61 microg/ml was reached at 12.5 +/- 2.50 min and thereafter ketamine concentrations decreased rapidly. The elimination half-life (t(1/2 z)) obtained was 62.37 +/- 17.37 min and mean residence time (MRT) was 77.33 +/- 19.12 min. The area under the curve (AUC) was 114.19 +/- 15.76 microg x min/ml.
De Lucas
J J
JJ
Cátedra de Farmacología, Farmacia y Terapéutica, Facultad de Veterinaria, Universidad Complutense de Madrid, Avda/Puerta de Hierro s.n., 28040 Madrid, Spain.
Rodríguez
C
C
Marín
M
M
González
F
F
Ballesteros
C
C
San Andrés
M I
MI
D000758:Anesthesia / Q000379:methods / Q000662:veterinary; D000777:Anesthetics / Q000494:pharmacology; D000778:Anesthetics, Dissociative / Q000493:pharmacokinetics*; D000818:Animals; D019540:Area Under Curve; D007093:Imidazoles / Q000494:pharmacology; D007273:Injections, Intramuscular / Q000662:veterinary; D007649:Ketamine / Q000493:pharmacokinetics*; D008657:Metabolic Clearance Rate; D020310:Struthioniformes / Q000097:blood / Q000378:metabolism / Q000502:physiology*
D000777:Anesthetics; D000778:Anesthetics, Dissociative; D007093:Imidazoles; D007649:Ketamine; C076257:romifidine