[Experimental hormonal carcinogenesis].
Experimental carcinogenesis associated with estrogen and progesterone treatment in the induction of mammary tumours and reported in the literature is discussed. The various investigations are compared and some theories are advanced. Techniques for the induction of ovarian tumours and tests carried out with steroids as anticarcinogenic competitive substances are reviewed. Both increased (nucleotidase, aminopeptidase) and decreased (alkaline phosphatase) enzyme values were observed in the case of estrogen induced cervicovaginal neoplasia in the ovariectomised rat.
Cacciari
P
P
Ospedale Ostetrico e Ginecologico S. Anna, Torino.
D000469:Alkaline Phosphatase / Q000097:blood; D000626:Aminopeptidases / Q000097:blood; D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology; D002277:Carcinoma / Q000139:chemically induced* / Q000201:enzymology* / Q000517:prevention & control; D004967:Estrogens / Q000009:adverse effects*; D005260:Female; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced* / Q000201:enzymology* / Q000517:prevention & control; D023421:Models, Animal; D009708:Nucleotidases / Q000097:blood; D010052:Ovariectomy; D011374:Progesterone / Q000009:adverse effects*; D011372:Progestins / Q000009:adverse effects*; D002583:Uterine Cervical Neoplasms / Q000139:chemically induced / Q000201:enzymology; D014625:Vaginal Neoplasms / Q000139:chemically induced / Q000201:enzymology
D016588:Anticarcinogenic Agents; D004967:Estrogens; D011372:Progestins; D011374:Progesterone; D009708:Nucleotidases; D000469:Alkaline Phosphatase; C030287:nucleotidase; D000626:Aminopeptidases