Effects of repeated restraint stress on serum electrolytes in ethanol-treated and water-treated rats.
The present study was designed to evaluate the effects of simultaneous ethanol administration (10%, v/v), and restraint stress (2 hrs/day for 5 day) on serum electrolytes. This restraint stress decreases serum concentration of Na(+), K(+), Ca(2+), phosphorus, and chloride. Ethanol treatment also decreased Na(+), K(+), Ca(2+), phosphorus, and chloride concentration. The decrease in Ca(2+) and phosphorus levels was greater for ethanol-treated restrained than water-treated restrained rats. Ethanol did not affect serum Mg(2+) while it was increased in restrained water-treated rats. Ethanol-treated restrained rats exhibited less serum Mg(2+) than ethanol-treated unrestrained or water-treated restrained rats. Possible mechanism involved in restraint or ethanol-induced changes of electrolytes is discussed. In conclusion, the result of this study suggest that alteration of serum electrolyte caused by repeated restrained in water-treated and ethanol-treated rats could possibly occur due to an increase in sympathetic activity leading to enhanced excretion of these electrolytes.
Yasmin
Farzana
F
Department of Biomedical Engineering, NED University of Engineering and Technology, Karachi, Pakistan.
Haleem
Darakhshan J
DJ
Haleem
M A
MA
D000284:Administration, Oral; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002118:Calcium / Q000097:blood; D002492:Central Nervous System Depressants / Q000008:administration & dosage*; D002712:Chlorides / Q000097:blood; D004326:Drinking; D004573:Electrolytes / Q000097:blood*; D000431:Ethanol / Q000008:administration & dosage*; D006400:Hematocrit; D008274:Magnesium / Q000097:blood; D008297:Male; D010758:Phosphorus / Q000097:blood; D011188:Potassium / Q000097:blood; D051381:Rats; D017208:Rats, Wistar; D012149:Restraint, Physical / Q000009:adverse effects*; D012964:Sodium / Q000097:blood; D013315:Stress, Psychological / Q000097:blood* / Q000209:etiology / Q000503:physiopathology; D013997:Time Factors; D014882:Water-Electrolyte Balance / Q000187:drug effects*
D001786:Blood Glucose; D002492:Central Nervous System Depressants; D002712:Chlorides; D004573:Electrolytes; D010758:Phosphorus; D000431:Ethanol; D012964:Sodium; D008274:Magnesium; D011188:Potassium; D002118:Calcium