[Uveitis immunopathology: currents knowledge, clinical correlation and research perspectives in the immue-ocular area].
The eye has multiple mechanisms of immune regulation implicated in the maintenance of ocular immune privilege. However, sometimes diseases or disorders appear and can cause clinical manifestations of intraocular inflammation; usually those diseases are collectively named "uveitis". Despite the uveitis is the main cause of eye morbidity and lost of visual function, the vast majority of the immune mechanisms involved in its generation remains unknown. In this article, the authors reviews the process of immune regulation inside the eye, the immunological mechanisms of damage implicated in the generation of uveitis, as well as the clinical aspects associated with the immune pathogenesis; in the last part of this paper we present the most recent trends in ocular research related to immunological damage in uveitis.
Jiménez Martínez
Maria Carmen
MC
Unidad de Investigación, Instituto de Oftalmología, Fundación Conde de Valenciana, IAP. Chimalpopoca 14, colonia Obrera, México, DF. CP 06800. mcjimenezm@salud.gob.mx
Carrera
Irvin
I
Pedroza Seres
Miguel
M
Jaimes
Martha
M
Schlaen
Ariel
A
Garfias
Yonathan
Y
D001324:Autoantigens / Q000276:immunology; D001327:Autoimmune Diseases / Q000276:immunology / Q000473:pathology; D001528:Behcet Syndrome / Q000150:complications; D005136:Eye Proteins / Q000276:immunology; D020022:Genetic Predisposition to Disease; D006680:HLA Antigens / Q000235:genetics / Q000276:immunology; D006801:Humans; D007108:Immune Tolerance; D007694:Killer Cells, Natural / Q000276:immunology; D018448:Models, Immunological; D009504:Neutrophils / Q000276:immunology; D012106:Research; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D014605:Uveitis / Q000145:classification / Q000276:immunology* / Q000473:pathology; D014607:Uveomeningoencephalitic Syndrome / Q000276:immunology / Q000473:pathology
D001324:Autoantigens; D005136:Eye Proteins; D006680:HLA Antigens