title: Myocardial infarction and venous thrombosis in a 42-year old woman with heterozygous methylenetetrahydrofolate reductase (MTHRF) gene mutation, hyperhomocysteinemia, and protein C deficiency.
abstract: OBJECTIVE
  Hyperhomocysteinemia and protein C deficiency have synergistic effect on the onset of thrombotic disease.
  
  
  METHODS
  We report a 42-year old woman with myocardial infarction and venous thrombosis in whom recognition of heterozygous MTHRF gene mutation, hyperhomocysteinemia, and protein C deficiency.
  
  
  RESULTS
  The patient was treated successfully with coronary artery bypass graft surgery and systemic anticoagulation.
  
  
  CONCLUSIONS
  Our report emphasize that a combined hyperhomocysteinemia, and protein C deficiency may be a high risk factor for arterial and venous thromboembolic events in young adults. These patients might be candidates for indefinite anticoagulation.
authors.forename: Omer
authors.initials: O
authors.lastname: Cakir
authors.forename: Orhan
authors.initials: O
authors.lastname: Ayyildiz
authors.forename: Mustafa
authors.initials: M
authors.lastname: Goz
authors.forename: Dede
authors.initials: D
authors.lastname: Sit
authors.forename: Nesimi
authors.initials: N
authors.lastname: Eren
mesh_terms: D000328:Adult; D005260:Female; D006579:Heterozygote; D006801:Humans; D020138:Hyperhomocysteinemia / Q000150:complications*; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D009154:Mutation; D009203:Myocardial Infarction / Q000209:etiology*; D020151:Protein C Deficiency / Q000150:complications*; D020246:Venous Thrombosis / Q000209:etiology*
chemical_list: D042965:Methylenetetrahydrofolate Reductase (NADPH2)