Action potential and QT prolongation not sufficient to cause Torsade de Pointes: role of action potential triangulation.
Grant
Augustus O
AO
Tranquillo
Joseph
J
D000200:Action Potentials / Q000187:drug effects*; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology; D001145:Arrhythmias, Cardiac / Q000503:physiopathology; D002121:Calcium Channel Blockers / Q000494:pharmacology; D020746:Calcium Channels, L-Type / Q000187:drug effects*; D006168:Guinea Pigs; D006827:Hydantoins; D048289:Imidazolidines / Q000494:pharmacology; D032383:Myocytes, Cardiac / Q000187:drug effects*; D009529:Nicardipine / Q000494:pharmacology; D018408:Patch-Clamp Techniques; D010627:Phenethylamines / Q000494:pharmacology; D010879:Piperazines / Q000494:pharmacology; D011817:Rabbits; D013449:Sulfonamides / Q000494:pharmacology; D016171:Torsades de Pointes / Q000503:physiopathology*
D000889:Anti-Arrhythmia Agents; D002121:Calcium Channel Blockers; D020746:Calcium Channels, L-Type; D006827:Hydantoins; D048289:Imidazolidines; D010627:Phenethylamines; D010879:Piperazines; D013449:Sulfonamides; C086123:azimilide; D009529:Nicardipine; C063533:dofetilide