title: Heparin-induced thrombosis with a normal platelet count.
abstract: Heparin is commonly used in the intensive care unit for preventing and treating thromboembolic disease. One of its more significant complications is heparin-induced thrombocytopenia (HIT), an immune-mediated disorder which can provoke an extreme prothrombotic state. We describe an unusual presentation of HIT, where thrombocytopenia was absent.
authors.affiliation: Department of Critical Care, Rockyview General Hospital, Calgary, Alberta, Canada. george.alvarez@calgaryhealthregion.ca
authors.forename: George F
authors.initials: GF
authors.lastname: Alvarez
authors.forename: David
authors.initials: D
authors.lastname: Bihari
authors.forename: David
authors.initials: D
authors.lastname: Collins
mesh_terms: D000328:Adult; D000925:Anticoagulants / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D002116:Calcitonin / Q000097:blood; D005260:Female; D005500:Follow-Up Studies; D006493:Heparin / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D006629:Hirudins; D006801:Humans; D007362:Intensive Care Units; D010314:Partial Thromboplastin Time; D010976:Platelet Count; D011498:Protein Precursors / Q000097:blood; D011994:Recombinant Proteins / Q000627:therapeutic use; D020521:Stroke / Q000175:diagnosis / Q000188:drug therapy; D013921:Thrombocytopenia / Q000139:chemically induced / Q000175:diagnosis; D013927:Thrombosis / Q000097:blood / Q000139:chemically induced* / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000503:physiopathology; D013997:Time Factors; D014057:Tomography, X-Ray Computed
chemical_list: D000925:Anticoagulants; D006629:Hirudins; D011498:Protein Precursors; D011994:Recombinant Proteins; D006493:Heparin; D002116:Calcitonin; C083544:lepirudin