[Therapeutic effect of Hongbeiyegen on alcohol-induced rat hepatic fibrosis].
OBJECTIVE
To observe the therapeutic effect of Hongbeiyegen [the root of Alchornea trewioides(Benth.) Muell.-Arg.] on alcohol-induced liver fibrosis (AF) in rats and explore its mechanism.


METHODS
In rats with AF, the serum levels of transforming growth factor beta1 (TGFbeta1) and tissue inhibitor of metalloproteinase-1 (TIMP-1) were detected along with examination of the changes in serum hyaluronic acid (HA), laminin (LN), procolagen type III (PC III), collagen type IV (C IV), glutamic-pyruvic transaminase (ALT) and glutamic-oxalacetic transaminase (AST) levels.


RESULTS
Compared with the control group, Hongbeiyegen could significantly reduce the levels of TGFbeta1, TIMP-1, HA, LN, PC III, CIV, ALT and AST in rats with AF.


CONCLUSIONS
Hongbeiyegen can relieve and ameliorate liver fibrosis possibly by inhibiting the expression of TGFbeta1 and TIMP-1.
Lü
Xiao-Yan
XY
College of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China. jiajia411816@126.com
Liu
Qiang
Q
Chen
Yu-Yao
YY
Song
Yu-Hong
YH
Lü
Zhi-Ping
ZP
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D024061:Collagen Type III / Q000097:blood; D024141:Collagen Type IV / Q000097:blood; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D000431:Ethanol; D019665:Euphorbiaceae / Q000737:chemistry*; D005260:Female; D006820:Hyaluronic Acid / Q000097:blood; D007797:Laminin / Q000097:blood; D008106:Liver Cirrhosis, Experimental / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male; D008517:Phytotherapy; D018517:Plant Roots / Q000737:chemistry*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D019715:Tissue Inhibitor of Metalloproteinase-1 / Q000097:blood; D053773:Transforming Growth Factor beta1 / Q000097:blood
D024061:Collagen Type III; D024141:Collagen Type IV; D004365:Drugs, Chinese Herbal; D007797:Laminin; D019715:Tissue Inhibitor of Metalloproteinase-1; D053773:Transforming Growth Factor beta1; C528815:hongbeiyegen; D000431:Ethanol; D006820:Hyaluronic Acid; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase