Graft versus host disease after orthotopic liver transplantation documented by analysis of short tandem repeat polymorphisms.
We report a case of graft versus host disease after liver transplantation in which the diagnosis was made by short tandem repeat analysis. A retrospective analysis using a bone marrow sample showed the presence of chimerism already at a time when the characteristic full clinical picture of graft versus host disease had not yet developed, opening the way for the early diagnosis and treatment.
Schöniger-Hekele
M
M
Universitatsklinik fur Innere Medizin IV, Klinische Abteilung Gastroenterologie und Hepatologie, Medical University of Vienna, Vienna, Austria. maximilian.schoeniger-hekele@meduniwien.ac.at
Müller
C
C
Kramer
L
L
Dauber
E
E
Mayr
W R
WR
Wrba
F
F
Rockenschaub
S
S
Mühlbacher
F
F
D000368:Aged; D046528:Chimerism; D005500:Follow-Up Studies; D006085:Graft Survival; D006086:Graft vs Host Disease / Q000175:diagnosis* / Q000188:drug therapy / Q000235:genetics; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008103:Liver Cirrhosis / Q000235:genetics* / Q000601:surgery*; D016031:Liver Transplantation / Q000009:adverse effects* / Q000379:methods; D008297:Male; D018598:Minisatellite Repeats; D011110:Polymorphism, Genetic; D018570:Risk Assessment; D018183:Transplantation Chimera / Q000235:genetics; D014184:Transplantation, Homologous; D016896:Treatment Outcome
D007166:Immunosuppressive Agents