title: Comparison of behavioral and psychological symptoms in early-onset and late-onset Alzheimer's disease.
abstract: BACKGROUND
  When comparing with early-onset Alzheimer's disease (EO-AD) and late-onset Alzheimer's disease (LO-AD), some symptomatological differences in clinical features can be seen between them. Rapid progression, more severe language problems or visuospatial dysfunction occur more often in EO-AD patients. However, there have been very few reports about the differences in behavioral and psychological symptoms between these two groups.
  
  
  OBJECTIVE
  The aim of this study was to demonstrate the differences in behavioral symptoms between EO-AD and LO-AD groups.
  
  
  METHODS
  Three hundred and seven consecutive outpatients with AD were put into an EO-AD group (46 patients) or a LO-AD group (261 patients). Comprehensive assessment batteries, including the Neuropsychiatric Inventory (NPI), were administered at the first medical assessment.
  
  
  RESULTS
  Significant differences were found between the EO-AD and LO-AD groups in terms of NPI total score (EO-AD: 10.3 +/- 10.9, LO-AD: 17.8 +/- 17.0, p = 0.004) and number of patients who experienced each NPI subscale score (delusion; EO-AD: 13.0%, LO-AD: 50.6%, p < 0.001). There were no differences in cognitive functions or dementia severity between two groups.
  
  
  CONCLUSIONS
  In EO-AD, behavioral and psychological symptoms are relatively fewer than LO-AD at the first medical assessment.
authors.affiliation: Department of Neuropsychiatry, Neuroscience, Ehime University Graduate School of Medicine, Ehime, Japan.
authors.forename: Yasutaka
authors.initials: Y
authors.lastname: Toyota
authors.forename: Manabu
authors.initials: M
authors.lastname: Ikeda
authors.forename: Shunichiro
authors.initials: S
authors.lastname: Shinagawa
authors.forename: Teruhisa
authors.initials: T
authors.lastname: Matsumoto
authors.forename: Naomi
authors.initials: N
authors.lastname: Matsumoto
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Hokoishi
authors.forename: Ryuji
authors.initials: R
authors.lastname: Fukuhara
authors.forename: Tomohisa
authors.initials: T
authors.lastname: Ishikawa
authors.forename: Takaaki
authors.initials: T
authors.lastname: Mori
authors.forename: Hiroyoshi
authors.initials: H
authors.lastname: Adachi
authors.forename: Kenjiro
authors.initials: K
authors.lastname: Komori
authors.forename: Hirotaka
authors.initials: H
authors.lastname: Tanabe
mesh_terms: D000203:Activities of Daily Living; D017668:Age of Onset; D000368:Aged; D000544:Alzheimer Disease / Q000453:epidemiology / Q000523:psychology*; D001526:Behavioral Symptoms / Q000453:epidemiology / Q000523:psychology*; D003702:Delusions; D004522:Educational Status; D005260:Female; D006212:Hallucinations; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D011597:Psychomotor Performance; D018709:Statistics, Nonparametric