title: Long lived microbubbles for oxygen delivery.
abstract: Exceptionally long lived microbubbles containing a fluorocarbon as part of their filling gas have been obtained by using a fluorinated phospholipid instead of a standard phospholipid as shell component. An unexpected, strong synergistic effect between the fluorocarbon gas and the fluorinated phospholipid has been discovered. Such bubbles could be used for in vivo oxygen delivery, ultrasound contrast imaging and drug delivery.
authors.affiliation: Systèmes Organisés Fluorés à Finalités Thérapeutiques (SOFFT), Institut Charles Sadron, Strasbourg Cedex, France.
authors.forename: Frédéric
authors.initials: F
authors.lastname: Gerber
authors.forename: Gilles
authors.initials: G
authors.lastname: Waton
authors.forename: Marie Pierre
authors.initials: MP
authors.lastname: Krafft
authors.forename: Thierry F
authors.initials: TF
authors.lastname: Vandamme
mesh_terms: D001802:Blood Substitutes / Q000737:chemistry; D003287:Contrast Media / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry; D005466:Fluorocarbons / Q000627:therapeutic use*; D006207:Half-Life; D045423:Microbubbles; D010100:Oxygen / Q000378:metabolism*; D010743:Phospholipids / Q000737:chemistry / Q000627:therapeutic use
chemical_list: D001802:Blood Substitutes; D003287:Contrast Media; D004337:Drug Carriers; D005466:Fluorocarbons; D010743:Phospholipids; D010100:Oxygen