Foxe view of lens development and disease.
The recent identification of a mutation in Foxe3 that causes congenital primary aphakia in humans marks an important milestone. Congenital primary aphakia is a rare developmental disease in which the lens does not form. Previously, Foxe3 had been shown to play a crucial role in vertebrate lens formation and this gene is one of the earliest integrators of several signaling pathways that cooperate to form a lens. In this review, we highlight recent advances that have led to a better understanding of the developmental processes and gene regulatory networks involved in lens development and disease.
Medina-Martinez
Olga
O
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.
Jamrich
Milan
M
D000818:Animals; D001035:Aphakia / Q000151:congenital / Q000235:genetics / Q000378:metabolism; D015785:Eye Diseases, Hereditary / Q000235:genetics* / Q000378:metabolism; D051858:Forkhead Transcription Factors / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology*; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D007908:Lens, Crystalline / Q000196:embryology* / Q000378:metabolism; D009154:Mutation; D029867:Xenopus Proteins / Q000096:biosynthesis / Q000235:genetics
C497673:FOXE3 protein, Xenopus; C404285:FOXE3 protein, human; D051858:Forkhead Transcription Factors; C498612:Foxe3 protein, mouse; D029867:Xenopus Proteins