title: Investigation on the association between atopic dermatitis and the development of mycosis fungoides in dogs: a retrospective case-control study.
abstract: In human medicine, the relationship between the immunodysregulation observed in atopic dermatitis (AD) and the development of mycosis fungoides (MF) has triggered considerable interest due to the increasing number of patients with MF who have a previous history of AD. The purpose of this retrospective case-control study was to investigate whether dogs diagnosed with MF were more likely to have AD. The records of 96 000 canine patients at the University of Florida were searched. Inclusion criteria were a clinical and histological diagnosis of MF. Dogs admitted to the University of Florida, Veterinary Medical Center during the same time period (1991-2004) without a diagnosis of MF were included as controls. Four controls for each study dog were randomly selected (matched by year of admission). Frequency of AD and other exposure variables were compared among case and control dogs by using conditional logistic regression. Records of 19 dogs with a diagnosis of MF were identified. Five of them (5/19, 26.3%) had previous diagnosis of AD. The odds of having MF was 12 times (OR = 12.54; 95% CI = 1.95-80.39; P < 0.01) higher in dogs with AD than in dogs without AD. In conclusion, this study suggests an association between AD and MF in dogs. Future studies are necessary to confirm this finding and to investigate the pathogenic mechanisms involved in this association.
authors.forename: D
authors.initials: D
authors.lastname: Santoro
authors.forename: R
authors.initials: R
authors.lastname: Marsella
authors.forename: J
authors.initials: J
authors.lastname: Hernandez
mesh_terms: D000818:Animals; D016022:Case-Control Studies; D003876:Dermatitis, Atopic / Q000150:complications / Q000453:epidemiology / Q000662:veterinary*; D004283:Dog Diseases / Q000453:epidemiology*; D004285:Dogs; D005260:Female; D005431:Florida / Q000453:epidemiology; D008297:Male; D009182:Mycosis Fungoides / Q000150:complications / Q000453:epidemiology / Q000662:veterinary*; D011996:Records / Q000662:veterinary; D012189:Retrospective Studies; D012878:Skin Neoplasms / Q000150:complications / Q000453:epidemiology / Q000662:veterinary*