Study of hydroxy propyl guar derivative for its gelling property and it's use in the formulation of tenoxicam gels.
Gels of tenoxicam 1% w/w were formulated using 2% w/w hydroxy propyl guar derivative and 3% w/w sodium carboxy methyl cellulose as gelling agents. A detailed rheological investigation was carried out to study the influence of preservative, drug and preservative, solvent system and the preservative, drug, solvent system and the preservative on the pseudoplastic behaviour of polymers. Hydroxy propyl guar derivative in 2% w/w strength resulted in gels with a higher pseudoplastic index value of 3.383 in contrast to an index value of 1.797 for a 3% w/w sodium carboxy methyl cellulose gels of a similar composition. The gels were stored at different temperatures and variations in pH values were recorded. Hydroxy propyl guar derivative based gels revealed variations in pH values over a narrow range in contrast to sodium carboxy methyl cellulose gels. The gels were subjected to short term stability studies by storing gels at refrigerated temperature, lab temperature, at 37 degrees C and at 45 degrees C. Gels based on hydroxy propyl guar derivative revealed better drug keeping qualities in contrast to sodium carboxy methyl cellulose stabilized gels. Release studies of tenoxicam from formulations across hairless albino mice skin revealed a zero order drug release pattern from both the formulations.
Swamy
N G N
NG
Government College of Pharmacy, Bangalore-560 027, India. ngnswami@yahoo.co.in
Dharmarajan
T S
TS
Paranjothi
K L K
KL
D000287:Administration, Topical; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000737:chemistry* / Q000378:metabolism; D002266:Carboxymethylcellulose Sodium / Q000737:chemistry; D002626:Chemistry, Pharmaceutical; D004337:Drug Carriers; D004355:Drug Stability; D004356:Drug Storage; D000431:Ethanol / Q000737:chemistry; D005782:Gels; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D051379:Mice; D008812:Mice, Hairless; D008954:Models, Biological; D009924:Organ Culture Techniques; D010226:Parabens / Q000737:chemistry; D010894:Piroxicam / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism; D011108:Polymers / Q000737:chemistry; D011134:Polysaccharides / Q000737:chemistry*; D011310:Preservatives, Pharmaceutical / Q000737:chemistry; D011409:Propylene Glycols / Q000737:chemistry; D012212:Rheology; D012869:Skin Absorption; D012995:Solubility; D012997:Solvents / Q000737:chemistry; D013696:Temperature; D013997:Time Factors; D014783:Viscosity
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004337:Drug Carriers; D005782:Gels; D010226:Parabens; D011108:Polymers; D011134:Polysaccharides; D011310:Preservatives, Pharmaceutical; D011409:Propylene Glycols; D012997:Solvents; C519976:hydroxypropyl guar; D010894:Piroxicam; C012504:polypropylene glycol; D000431:Ethanol; C015358:methylparaben; D002266:Carboxymethylcellulose Sodium; C032801:tenoxicam; C006068:propylparaben