Dynamic kinetic resolution catalyzed by enzymes and metals.
The development of new strategies to efficiently synthesize chiral compounds is of extreme importance. Dynamic kinetic resolution is a powerful tool to transform a racemic mixture into one enantiomer. This strategy overcomes the limitation of the maximum 50% yield in a kinetic resolution by combining it with an in situ racemization of the substrate. Recently, the coupling of enzymes and transition metals for dynamic kinetic resolution of a variety of molecules has attracted considerable attention and a deeper understanding of the compatibility of these two catalysts has been achieved.
Martín-Matute
Belén
B
Departamento de Química Orgánica, Facultad de Ciencias, Universidad Autónoma de Madrid, Cantoblanco Universidad, 28059 Madrid.
Bäckvall
Jan-E
JE
D000085:Acetates / Q000737:chemistry; D000438:Alcohols / Q000737:chemistry; D000588:Amines / Q000737:chemistry; D002384:Catalysis; D004798:Enzymes / Q000378:metabolism*; D007700:Kinetics; D008670:Metals / Q000737:chemistry*; D013237:Stereoisomerism
D000085:Acetates; D000438:Alcohols; D000588:Amines; D004798:Enzymes; D008670:Metals