Less fat with nesfatin.
The brain receives information on the body's fuel supply through a bewildering array of chemical messengers that signal either negative or positive energy balance. Nesfatin-1, a secreted protein of previously unknown function, acts as a satiety factor. Nesfatin-1 suppresses appetite in both the short term and the long term, is made by neurons in brain centers that regulate energy balance and might act via melanocortin pathways. Nesfatin-1 is the latest addition to the surprisingly large number of chemical messengers telling the body that the tank is full.
Colmers
William F
WF
Department of Pharmacology, University of Alberta, 9-36 MSB Edmonton, Alberta, Canada. william.colmers@ualberta.ca
D000818:Animals; D001069:Appetite Regulation; D002135:Calcium-Binding Proteins; D004268:DNA-Binding Proteins; D006801:Humans; D007031:Hypothalamus / Q000502:physiology; D053486:Melanocortins / Q000502:physiology; D009419:Nerve Tissue Proteins / Q000502:physiology*; D009474:Neurons / Q000502:physiology; D000080866:Nucleobindins; D051381:Rats
D002135:Calcium-Binding Proteins; D004268:DNA-Binding Proteins; D053486:Melanocortins; C000630650:NUCB2 protein, human; D009419:Nerve Tissue Proteins; C000630652:Nucb1 protein, rat; D000080866:Nucleobindins