title: [New insights into the pathogenesis of ANCA-positive vasculitides].
abstract: Recent studies provided new insights into the pathogenesis of vasculitides associated with antineutrophil cytoplasm antibodies (ANCA). They yield more information about the pathogenic role of ANCA, the initiation of the immune response against proteinase 3, the expression of ANCA target antigens on neutrophil surfaces, endothelial damage and the mechanisms of vasculitis associated with propylthiouracil. The pathogenic role of antimyeloperoxidase antibodies has been established in vitro and in vivo in animal models and in human. A pathogenic role for antiproteinase 3 antibodies has not yet been clearly established in vivo although it is well documented in vitro.
authors.affiliation: Service de médecine interne, Centre national de références pour les vascularites systémiques et la sclérodermie systémique, Hôpital Cochin, AP-HP, Université Paris V, Paris, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Guilpain
authors.forename: Loïc
authors.initials: L
authors.lastname: Guillevin
authors.forename: Luc
authors.initials: L
authors.lastname: Mouthon
mesh_terms: D000328:Adult; D000818:Animals; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000235:genetics / Q000276:immunology; D015415:Biomarkers; D018925:Chemokines / Q000502:physiology; D015267:Churg-Strauss Syndrome / Q000175:diagnosis / Q000209:etiology / Q000276:immunology; D003713:Dendritic Cells / Q000276:immunology; D004195:Disease Models, Animal; D000939:Epitopes; D005260:Female; D014890:Granulomatosis with Polyangiitis / Q000175:diagnosis / Q000209:etiology / Q000276:immunology; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D051379:Mice; D053146:Myeloblastin / Q000276:immunology; D009195:Peroxidase / Q000276:immunology; D011110:Polymorphism, Genetic; D011441:Propylthiouracil / Q000276:immunology; D051381:Rats; D011921:Rats, Inbred WKY; D012306:Risk; D014657:Vasculitis / Q000175:diagnosis / Q000209:etiology / Q000235:genetics / Q000276:immunology* / Q000503:physiopathology
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic; D015415:Biomarkers; D018925:Chemokines; D000939:Epitopes; D011441:Propylthiouracil; D009195:Peroxidase; D053146:Myeloblastin