[Prognostic analysis of T1 and T2 stage gallbladder cancer with invasion within the gallbladder wall].
OBJECTIVE
To explore the impact of different treatment procedure on the prognosis of T1 and T2 stage gallbladder cancer with the invasion within the gallbladder wall.


METHODS
A retrospective analysis was conducted on 45 patients with pathologic stage T1 and T2 gallbladder cancer who had undergone surgical resection from 1990 and 2005.


RESULTS
Depth of invasion (T), radical cholecystectomy and postoperative adjuvant chemotherapy were independent prognostic factors on Cox multivariate analysis. The 5-year survival rates of patients with T1a, T1b and T2 stage gallbladder cancer who underwent simple cholecystectomy without postoperative adjuvant chemotherapy were 100%, 67% and 0, respectively. The survival rate in T2 was significantly lower than those in T1a and T1b. Without postoperative adjuvant chemotherapy, the 5-year survival rates of patients with T2 stage gallbladder cancer who underwent simple cholecystectomy and radical cholecystectomy were 0 and 63%, respectively. There was significant difference between the survival time of T2 patients who had undergone simple cholecystectomy with and without postoperative adjuvant chemotherapy.


CONCLUSIONS
The prognosis of patients with T1 stage gallbladder cancer is much better than that of T2 stage. The 5-year survival rates of patients with T1a and T1b stage gallbladder cancer who received simple cholecystectomy are relatively good. Radical cholecystectomy and postoperative adjuvant chemotherapy can improve the prognosis of patients with T2 gallbladder cancer.
Hou
Chun-sheng
CS
Department of General Surgery, Peking University Third Hospital, Beijing 100083, China. chunshenghou@126.com
Xu
Zhi
Z
Zhang
Tong-lin
TL
Peng
Ying
Y
Ling
Xiao-feng
XF
Wang
Li-xin
LX
Zhou
Xiao-si
XS
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017024:Chemotherapy, Adjuvant; D002763:Cholecystectomy; D003131:Combined Modality Therapy; D005260:Female; D005704:Gallbladder / Q000187:drug effects / Q000473:pathology* / Q000601:surgery; D005706:Gallbladder Neoplasms / Q000473:pathology* / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D011379:Prognosis; D012189:Retrospective Studies; D016019:Survival Analysis