[Controlled cytostatic therapy in the early periods after surgery for glaucoma: preliminary results].
A procedure is proposed to contrast a clear solution of the cytostatic agent 5-fluorouracil during subconjunctival administration early after surgery for glaucoma in order to prevent hyperscarring. For this, after dissolution of 5-fluorouracil with 0.1% dexamethasone solution, 0.05 ml of 0.08% trypan blue solution was added to an injection syringe until the mixture produced a uniform light blue color. 0.1-0.2 ml of the mixture was subconjunctivally injected. The proposed procedure makes it possible to visualize the site of injection with a high degree of reliability: the penetration of the agent into the given area, the area of its spread, and the volume of the agent's administration, to view external filtration and possible intrachamber flux, and to provide information on the topography of formed outflow tracts.
Shmyreva
V F
VF
Petrov
S Iu
SIu
Antonov
A A
AA
Pimenidi
M K
MK
D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage*; D002921:Cicatrix / Q000473:pathology / Q000517:prevention & control*; D004396:Coloring Agents / Q000008:administration & dosage*; D003228:Conjunctiva; D003907:Dexamethasone / Q000008:administration & dosage / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D005472:Fluorouracil / Q000008:administration & dosage; D005901:Glaucoma / Q000601:surgery*; D005938:Glucocorticoids / Q000008:administration & dosage* / Q000627:therapeutic use; D006801:Humans; D007267:Injections; D016343:Monitoring, Intraoperative; D011183:Postoperative Complications; D014130:Trabeculectomy / Q000009:adverse effects*; D016896:Treatment Outcome; D014343:Trypan Blue / Q000008:administration & dosage
D000964:Antimetabolites, Antineoplastic; D004396:Coloring Agents; D005938:Glucocorticoids; D003907:Dexamethasone; D014343:Trypan Blue; D005472:Fluorouracil