title: Magnetic resonance imaging with liver-specific contrast agent in primary amyloidosis and intrahepatic cholestasis.
abstract: Magnetic resonance imaging (MRI) findings in hepatic amyloidosis are not well defined. Here, we report on a patient with renal failure caused by primary amyloidosis (AL type) who developed jaundice. Ultrasound and computed tomography were normal except for some ascites. MRI with oral manganese-containing contrast agent revealed several focal areas without contrast uptake in the hepatocytes and no bile secretion after 8 hours. No extrahepatic bile obstructions were found. Liver biopsy showed severe intraportal, vascular, and parenchymal amyloidosis causing severe cholestasis and atrophy of hepatocytes.
authors.affiliation: Department of Radiology, Copenhagen University Hospital at Herlev, Denmark. jaml@helh.regionh.dk
authors.forename: J M
authors.initials: JM
authors.lastname: Møller
authors.forename: E
authors.initials: E
authors.lastname: Santoni-Rugiu
authors.forename: E
authors.initials: E
authors.lastname: Chabanova
authors.forename: V
authors.initials: V
authors.lastname: Løgager
authors.forename: A B
authors.initials: AB
authors.lastname: Hansen
authors.forename: H S
authors.initials: HS
authors.lastname: Thomsen
mesh_terms: D000686:Amyloidosis / Q000175:diagnosis*; D001284:Atrophy; D001706:Biopsy; D049448:Cholangiopancreatography, Magnetic Resonance; D002780:Cholestasis, Intrahepatic / Q000175:diagnosis*; D003287:Contrast Media; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D006801:Humans; D008111:Liver Function Tests; D008297:Male; D008345:Manganese; D008875:Middle Aged; D018084:Ultrasonography, Interventional
chemical_list: C504368:CMC-001; D003287:Contrast Media; D008345:Manganese