5-HT1A receptor-mediated apoptosis: death by JNK?
There is growing interest in the potential use of 5-HT(1A) receptor agonists as neuroprotective agents in stroke and traumatic brain injury. However, a new study using a recombinant 5-HT(1A) receptor cell line suggests that these agonists may promote as well as inhibit apoptotic responses. Because heterologously expressed receptors may couple promiscuously to inappropriate signal transduction pathways, the results should be interpreted with caution.
Meller
Emanuel
E
Millhauser Laboratories, Department of Psychiatry, New York University School of Medicine, New York, NY 10016, USA. emanuel.meller@med.nyu.edu
D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D001930:Brain Injuries / Q000188:drug therapy / Q000201:enzymology*; D015870:Gene Expression; D006801:Humans; D048670:MAP Kinase Kinase 4 / Q000378:metabolism*; D018696:Neuroprotective Agents / Q000494:pharmacology* / Q000627:therapeutic use; D044282:Receptor, Serotonin, 5-HT1A / Q000235:genetics / Q000627:therapeutic use; D011994:Recombinant Proteins / Q000235:genetics / Q000494:pharmacology / Q000627:therapeutic use; D017366:Serotonin Receptor Agonists / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects; D020521:Stroke / Q000188:drug therapy / Q000201:enzymology*
D018696:Neuroprotective Agents; D011994:Recombinant Proteins; D017366:Serotonin Receptor Agonists; D044282:Receptor, Serotonin, 5-HT1A; D048670:MAP Kinase Kinase 4