Association of serum apolipoprotein A-II concentration with combined hyperlipidemia and impaired glucose tolerance.
We studied the relationship of serum apolipoprotein A-II concentration with biochemical parameters of lipid and carbohydrate metabolism, type of hyperlipidemia, and insulin sensitivity in male patients with hyperlipidemia. High concentration of apolipoprotein A-II was associated with increased indices of atherogenic lipoproteins and high-density lipoprotein-mediated reverse cholesterol transport, combined hyperlipidemia, and decreased insulin sensitivity calculated with consideration for glucose and insulin levels in glucose tolerance test and body weight.
Aleksandrovich
O V
OV
Department of Metabolic Disorders, State Research Center for Preventive Medicine, Russian Health Service, Moscow. oalexandrovitch@gnicpm.ru
Ozerova
I N
IN
Olfer'ev
A M
AM
Serdyuk
A P
AP
Metel'skaya
V A
VA
Perova
N V
NV
D000328:Adult; D016633:Apolipoprotein A-II / Q000097:blood*; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight; D050260:Carbohydrate Metabolism / Q000502:physiology*; D018149:Glucose Intolerance / Q000097:blood*; D005951:Glucose Tolerance Test; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood*; D007328:Insulin / Q000097:blood; D050356:Lipid Metabolism / Q000502:physiology*; D008074:Lipoproteins / Q000097:blood; D008297:Male; D008875:Middle Aged; D018709:Statistics, Nonparametric
D016633:Apolipoprotein A-II; D001786:Blood Glucose; D007328:Insulin; D008074:Lipoproteins