title: [Measures for patients taking psychotropic drugs who undergo elective surgery].
abstract: Psychotropic drugs can increase the risk of perioperative complications when given in combination with anaesthesia. Evidence-based guidelines that address this issue are lacking. Consensus-based recommendations were formed for the perioperative management of these patients based on the available literature and a systematic evaluation of perioperative risks by the medical specialists directly involved. Patients who use lithium, monoamine oxidase inhibitors (MAOIs), tricyclic antidepressants or clozapine are at risk of experiencing adverse interactions. The anaesthesiology literature recommends discontinuing irreversible MAOIs and lithium in all cases, and tricyclic antidepressants in patients with systemic disorders. With the exception of lithium, the risks of psychiatric relapse or recurrence associated with discontinuation necessitate intensive integrated psychiatric treatment. Continuation of treatment under strict haemodynamic observation may also be an option in some cases. Patients taking selective serotonin reuptake inhibitors (SSRIs) should be observed carefully for psychological instability and physical abnormalities, and clinicians should be aware of medications that could increase the risk of haemorrhage when used in combination with SSRIs. In these cases, a psychiatrist should be consulted. The same is true for patients taking antipsychotic or other antidepressant medication who develop psychological instability or have a systemic disorder. Given the widespread use ofpsychotropic drugs and the seriousness of the associated risks, it is recommended that the decision whether to continue or discontinue psychotropic medication should become a standard component of preoperative assessment.
authors.affiliation: Universitair Medisch Centrum Groningen, afd. Algemene Interne Geneeskunde, Postbus 30.001, 9700 RB Groningen. f.j.huijse@int.umcg.nl
authors.forename: F J
authors.initials: FJ
authors.lastname: Huyse
authors.forename: D J
authors.initials: DJ
authors.lastname: Touw
authors.forename: R J M
authors.initials: RJ
authors.lastname: Strack van Schijndel
authors.forename: J J
authors.initials: JJ
authors.lastname: de Lange
authors.forename: J P J
authors.initials: JP
authors.lastname: Slaets
mesh_terms: D000758:Anesthesia; D004347:Drug Interactions; D017558:Elective Surgical Procedures / Q000592:standards*; D006801:Humans; D001523:Mental Disorders / Q000188:drug therapy*; D010347:Patient Care Planning; D019990:Perioperative Care; D011619:Psychotropic Drugs / Q000009:adverse effects / Q000627:therapeutic use*; D012008:Recurrence; D018570:Risk Assessment; D012307:Risk Factors
chemical_list: D011619:Psychotropic Drugs