title: Analysis of substitution events in HIV-1 vif gene of the Korean clade.
abstract: Nucleotide and amino acid substitution pattern in vif gene of the Korean clade of HIV-1 isolated from Koreans were analyzed using consensus sequences. At nucleotide level, transition/transversion substitution ratio was 1.88, and nonsynonymous/synonymous substitution ratio was 2.67, suggesting a divergent evolution in the Korean clade. At amino acid level, there were 17 substitutions and G-->E substitution at position 37 may be responsible for change in predicted secondary structure.
authors.affiliation: School of Life Sciences, Chungbuk National University, Cheongju, Republic of Korea.
authors.forename: Chan Seung
authors.initials: CS
authors.lastname: Park
authors.forename: Mi Sook
authors.initials: MS
authors.lastname: Kim
authors.forename: Hyun Ah
authors.initials: HA
authors.lastname: Yi
authors.forename: Dong Hun
authors.initials: DH
authors.lastname: Lee
authors.forename: Keon Myung
authors.initials: KM
authors.lastname: Lee
authors.forename: Chan Hee
authors.initials: CH
authors.lastname: Lee
mesh_terms: D000595:Amino Acid Sequence; D019943:Amino Acid Substitution; D044466:Asian People; D001483:Base Sequence; D016384:Consensus Sequence; D019143:Evolution, Molecular; D016346:Gene Products, vif / Q000737:chemistry / Q000235:genetics; D016341:Genes, vif; D015658:HIV Infections / Q000821:virology*; D015497:HIV-1 / Q000145:classification / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D017433:Protein Structure, Secondary; D016415:Sequence Alignment; D054320:vif Gene Products, Human Immunodeficiency Virus
chemical_list: D016346:Gene Products, vif; D054320:vif Gene Products, Human Immunodeficiency Virus