Absence of relationship between MTTP haplotypes and longevity.
BACKGROUND
Polymorphisms for the microsomal triglyceride transfer protein (MTTP) gene have been associated with longevity and with lower risk for cardiovascular mortality. However, the association of MTTP with longevity has been contested in a large German collection of nonagenarians and centenarians.


METHODS
We made a detailed characterization of MTTP haplotype carrier status in a cohort of 1398 old men and women (mean age 78 years) and a population-based cohort (n = 777) of younger controls (mean age 40 years) in Oxford, England.


RESULTS
There were no significant differences in haplotypes for MTTP gene between the younger and older age groups.


CONCLUSIONS
This study, which adopted a more detailed genetic analysis of the MTTP gene in a large case-control study of older people provides reliable evidence against any significant association of the MTTP gene with longevity.
Neville
Matt J
MJ
Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, UK.
Clarke
Robert
R
Evans
John Grimley
JG
Rubinsztein
David C
DC
Karpe
Fredrik
F
D000328:Adult; D000368:Aged; D002318:Cardiovascular Diseases / Q000235:genetics; D002352:Carrier Proteins / Q000235:genetics*; D015331:Cohort Studies; D005260:Female; D005819:Genetic Markers / Q000235:genetics; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium; D008136:Longevity / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D012306:Risk; D018401:Sample Size; D006113:United Kingdom
D002352:Carrier Proteins; D005819:Genetic Markers; C106092:microsomal triglyceride transfer protein