title: Evaluation of insulin-like growth factor-1 in a mouse model of long-term abdominal radiation toxicity.
abstract: The purpose of these experiments was to test whether a brief course of insulin-like growth factor-1 (IGF-1) injection (escalating doses) concomitant to irradiation ameliorates radiation-induced kidney dysfunction and lethal bowel toxicity in a mouse model of unilateral high-dose irradiation of the kidney and adjacent bowel. The kidney function was assessed by means of repeated 99mTc-dimercaptosuccinate scans (every six weeks) during a maximum follow-up of 49 weeks. The experiments with single fractions of 12 Gy and 15 Gy revealed only minor differences in the severity of kidney dysfunction and no reduction in lethal bowel toxicity from IGF-1 treatment In the absence of any significant radioprotective effect, other strategies of response modification need to be developed.
authors.affiliation: Department of Radiation Oncology, Klinikum rechts der Isar der Technischen Universität München, Munich, Germany. cnied@hotmail.com
authors.forename: Carsten
authors.initials: C
authors.lastname: Nieder
authors.forename: Lu
authors.initials: L
authors.lastname: Cai
authors.forename: Wolfgang A
authors.initials: WA
authors.lastname: Weber
authors.forename: Sabine
authors.initials: S
authors.lastname: Schill
authors.forename: Nicolaus
authors.initials: N
authors.lastname: Andratschke
authors.forename: Markus
authors.initials: M
authors.lastname: Schwaiger
authors.forename: Michael
authors.initials: M
authors.lastname: Molls
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004307:Dose-Response Relationship, Radiation; D005260:Female; D007334:Insulin-Like Growth Factor I / Q000494:pharmacology*; D007410:Intestinal Diseases / Q000209:etiology / Q000517:prevention & control*; D007422:Intestines / Q000528:radiation effects; D007668:Kidney / Q000000981:diagnostic imaging / Q000528:radiation effects; D007674:Kidney Diseases / Q000000981:diagnostic imaging / Q000209:etiology / Q000517:prevention & control*; D051379:Mice; D008809:Mice, Inbred C3H; D011833:Radiation Injuries, Experimental / Q000000981:diagnostic imaging / Q000517:prevention & control*; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D019783:Technetium Tc 99m Dimercaptosuccinic Acid
chemical_list: D011837:Radiation-Protective Agents; D019275:Radiopharmaceuticals; D019783:Technetium Tc 99m Dimercaptosuccinic Acid; D007334:Insulin-Like Growth Factor I