Analgesic, antipyretic and Ulcerogenic properties of an indigenous formulation--Kalpaamruthaa.
A modified indigenous Siddha formulation Kalpaamruthaa (KA), containing Semecarpus anacardium nut milk extract (SA), dried powder of Emblica officinalis (EO) fruit and honey was evaluated for its analgesic, antipyretic and Ulcerogenic properties. Both SA and KA, at a dose of 150 mg/kg b. wt were compared with the standard drug diclofenac sodium. KA exhibited an enhanced effect on all properties compared with that found with sole SA treatment, and is likely to be due to synergistic and additive interactions within the complex mixture of phytochemicals present in KA.
Mythilypriya
Rajendran
R
Department of Medical Biochemistry, Dr ALM. Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai 600 113, India.
Shanthi
Palanivelu
P
Sachdanandam
Panchanatham
P
D000700:Analgesics / Q000009:adverse effects / Q000737:chemistry / Q000494:pharmacology*; D018712:Analgesics, Non-Narcotic / Q000009:adverse effects / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D001172:Arthritis, Rheumatoid / Q000378:metabolism; D004008:Diclofenac / Q000737:chemistry / Q000494:pharmacology; D015232:Dinoprostone / Q000378:metabolism; D005260:Female; D005638:Fruit / Q000737:chemistry; D005753:Gastric Mucosa / Q000187:drug effects / Q000473:pathology; D008297:Male; D051379:Mice; D029842:Phyllanthus emblica / Q000737:chemistry; D010936:Plant Extracts / Q000009:adverse effects / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D031023:Semecarpus / Q000737:chemistry; D013276:Stomach Ulcer / Q000139:chemically induced* / Q000473:pathology; D013997:Time Factors
D000700:Analgesics; D018712:Analgesics, Non-Narcotic; C510231:Kalpaamruthaa; D010936:Plant Extracts; D004008:Diclofenac; D015232:Dinoprostone