title: Should dialysis be offered to cancer patients with acute kidney injury?
abstract: OBJECTIVE
  Cancer patients are at high risk for acute kidney injury (AKI), which is associated with high mortality when renal replacement therapy is required. Because physicians might be reluctant to offer dialysis to patients with malignancies, we sought to appraise outcomes in critically ill cancer patients (mainly with hematological malignancies) who received renal replacement therapy for AKI complicating cancer management.
  
  
  METHODS
  Cohort study including consecutive patients who received renal replacement therapy for AKI complicating cancer management, over a 42-month period. Their mortality was compared with that of non-cancer patients who received renal replacement therapy in the same center over the same study period (control group).
  
  
  METHODS
  A 12-bed medical intensive care unit in a university hospital.
  
  
  RESULTS
  94 critically-ill cancer patients met the inclusion criteria. Median SAPS II was 53 (IQR 40-75) and median Logistic Organ Dysfunction score was 7 (IQR 5-10). The etiology of AKI was multiple in most patients (248 identified factors in 93 patients). Hospital mortality was 51.1%. Two variables were independently associated with hospital mortality: the severity of associated organ failures at ICU admission (OR, 1.33; 95% CI, 1.11-1.59; per point) and renal function deterioration after ICU admission (OR, 5.42; 95% CI, 1.62-18.11). Characteristics of the malignancy were not associated with hospital mortality. The presence of cancer had no detectable influence on hospital mortality after adjustment for gender, age, acute severity as assessed by the SAPS II score, and chronic health status [OR 1.2, 95% CI 0.63-2.27; p=0.57].
  
  
  CONCLUSIONS
  ICU admission should be considered in selected critically ill cancer patients with AKI requiring renal replacement therapy.
authors.affiliation: Medical Intensive Care Unit, Saint-Louis University Hospital, Assistance Publique des Hôpitaux de Paris and Paris VII University, 1 av. Claude Vellefaux, 75010, Paris, France. michael.darmon@sls.ap-hop-paris.fr.|Medical ICU, Henri Mondor University Hospital, 51 avenue du Maréchal de Lattre de Tassigny, 94000, Créteil, France. michael.darmon@sls.ap-hop-paris.fr.
authors.forename: Michael
authors.initials: M
authors.lastname: Darmon
authors.affiliation: Medical Intensive Care Unit, Saint-Louis University Hospital, Assistance Publique des Hôpitaux de Paris and Paris VII University, 1 av. Claude Vellefaux, 75010, Paris, France.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Thiery
authors.affiliation: Medical Intensive Care Unit, Saint-Louis University Hospital, Assistance Publique des Hôpitaux de Paris and Paris VII University, 1 av. Claude Vellefaux, 75010, Paris, France.
authors.forename: Magali
authors.initials: M
authors.lastname: Ciroldi
authors.affiliation: Department of Biostatistics, Saint-Louis University Hospital, Assistance Publique des Hôpitaux de Paris and Paris VII University, Paris, France.
authors.forename: Raphaël
authors.initials: R
authors.lastname: Porcher
authors.affiliation: Medical Intensive Care Unit, Saint-Louis University Hospital, Assistance Publique des Hôpitaux de Paris and Paris VII University, 1 av. Claude Vellefaux, 75010, Paris, France.
authors.forename: Benoît
authors.initials: B
authors.lastname: Schlemmer
authors.affiliation: Medical Intensive Care Unit, Saint-Louis University Hospital, Assistance Publique des Hôpitaux de Paris and Paris VII University, 1 av. Claude Vellefaux, 75010, Paris, France.
authors.forename: Élie
authors.initials: É
authors.lastname: Azoulay
mesh_terms: D058186:Acute Kidney Injury / Q000150:complications* / Q000401:mortality / Q000628:therapy; D000328:Adult; D000368:Aged; D015331:Cohort Studies; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D007362:Intensive Care Units; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000150:complications*; D006435:Renal Dialysis; D017582:Renal Replacement Therapy; D012720:Severity of Illness Index