title: New approaches to invasive fungal infections in acute leukemia and hematopoietic stem cell transplant patients.
abstract: Recognition and treatment of invasive fungal infections in acute leukemia and hematopoietic stem cell transplant patients are important clinical challenges. New diagnostic tools, such as fungal serologic assays and high-resolution CT scans, offer the hope for earlier initiation of antifungal therapy and improved treatment results. New antifungal agents offer choices that in some cases are less toxic than older drugs and in other cases are more efficacious. Combining the new diagnostic tools with new drugs, novel strategies are being evaluated to change our approaches to these deadly infections.
authors.affiliation: Blood and Marrow Transplant Program, Division of Hematology/Oncology, University of Florida Shands Cancer Center, 1376 Mowry Road, Room 145, Gainesville, FL 32610-3633, USA. wingajr@medicine.ufl.edu
authors.forename: John R
authors.initials: JR
authors.lastname: Wingard
mesh_terms: D019072:Antibiotic Prophylaxis / Q000379:methods*; D000935:Antifungal Agents / Q000627:therapeutic use*; D001228:Aspergillosis / Q000175:diagnosis / Q000188:drug therapy / Q000517:prevention & control; D002177:Candidiasis / Q000175:diagnosis / Q000188:drug therapy / Q000517:prevention & control; D002986:Clinical Trials as Topic; D005690:Galactose / Q000031:analogs & derivatives; D005936:Glucans / Q000097:blood; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D007938:Leukemia / Q000150:complications / Q000382:microbiology* / Q000628:therapy; D008351:Mannans / Q000097:blood
chemical_list: D000935:Antifungal Agents; D005936:Glucans; D008351:Mannans; C012990:galactomannan; D005690:Galactose