The effects of Liuwei Dihuang decoction on the gene expression in the hippocampus of senescence-accelerated mouse.
Liuwei Dihuang decoction (LW), a traditional Chinese medicinal prescription, enhances the cognitive function of CNS by significant modulating effects on some of the gene expressions. Expressions of genes, such as DUSP12, NSF, STUB1, CaMKIIalpha, AMFR, UQCRFS1 and other 11 novel genes without any functional clues changed significantly. These genes are involved in the protein-tyrosine phosphatase family, the AAA (ATPases associated with diverse cellular activities) gene family, the serine/threonine protein kinases family, ubiquitin ligase, mitochondrial function and so on.
Cheng
Xiao-Rui
XR
Beijing Institute of Pharmacology and Toxicology, Beijing 100850, PR China. chengxiaorui@hotmail.com
Zhou
Wen-Xia
WX
Zhang
Yong-Xiang
YX
D000375:Aging; D000470:Alkaloids; D000544:Alzheimer Disease / Q000517:prevention & control; D000818:Animals; D002800:Cholinesterase Inhibitors / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D018076:DNA, Complementary / Q000032:analysis; D004365:Drugs, Chinese Herbal; D005786:Gene Expression Regulation; D006624:Hippocampus / Q000187:drug effects*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D016133:Polymerase Chain Reaction; D017027:Protein Tyrosine Phosphatases / Q000235:genetics*; D012717:Sesquiterpenes / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use
D000470:Alkaloids; D002800:Cholinesterase Inhibitors; D018076:DNA, Complementary; D004365:Drugs, Chinese Herbal; C042579:Liuwei Dihuang Decoction; D010936:Plant Extracts; D012717:Sesquiterpenes; C050426:huperzine A; D017027:Protein Tyrosine Phosphatases