[Immigration and HIV-1 infection: clinical manifestations, subtypes and evolution of 78 patients attended during the last 5 years].
OBJECTIVE
To analyse the characteristics and HIV-1 subtype in a group of HIV+ hospitalised immigrants in our Infectious Diseases Unit.


METHODS
Clinical reports of 78 immigrants HIV+ were reviewed. HIV-1 subtyping was carried out examining the protease and transcriptase genes by phylogenetic analysis. Statistical study was done by SPSS 11.0 program.


RESULTS
57% of patients come from sub-Saharian Africa. Mainly they had been infected by heterosexual contact. HIV was diagnosed at the hospitalisation time in 35 cases. Only 28% were receiving highly active antiretroviral therapy and 48,7% had CD4+ cells less than 200/microl. The more frequent diagnosed diseases were: tuberculosis (20.5%), candidiasis (24.4%), bacterial pneumonia (19.2%) and malaria (21.8%). HIV-1 subtype B was isolated in 26 patients, none Africans. Twenty nine individuals (52.8%) were infected with HIV-1 non-B subtypes. Relationship between HIV-1 subtype, immunodepression, diagnosed diseases and origin countries was not found apart from malaria.


CONCLUSIONS
Most HIV-1 infected immigrants are from Africa, being predominantly infected with HIV-1 non-B subtypes. No relationship between HIV subtype and diagnosed diseases was found.
Valencia Ortega
M Eulalia
ME
Servicio de Enfermedades Infecciosas, Hospital Carlos III, Madrid, España.
Holguín Fernández
Africa
A
Moreno Celda
Victoria
V
Alvarez Ferrero
Amparo
A
Lago Núñez
Mar
M
González Lahoz
Juan
J
D000328:Adult; D000368:Aged; D004641:Emigration and Immigration; D005260:Female; D015658:HIV Infections / Q000453:epidemiology*; D015497:HIV-1 / Q000145:classification*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D013030:Spain / Q000453:epidemiology