[Simulation on the process of female osteoporosis and its prevention by physical activity].
Abstract The processs of female Osteoporosis and its prevention by Physical activity were simulated using anisotropic bone remodelling model with mechanostat combining with finite element method. The results show that bone mass declines slowly at the beginning, bone loss accelerates in postmenopause and bone mass declines 25. 84%-28.63% at the age of 60 and 38.50%-40.44% at the age of 80. Bone mass increases 3.05%-10.26% by an increase of 10%-20% in physical activity. The above results are consistent with clinical observations,which proves that declination of mechanical usage is the primary factor leading to osteoporosis, menopause quickens the process of female osteoporosis, physical activity can decelerate it.
Ma
Zongmin
Z
Institute of Biomedical Engineering, Dalian University, Dalian 116021, China.
Li
Shuxian
S
Zhu
Xinghua
X
Gong
He
H
D000368:Aged; D001696:Biomechanical Phenomena; D016723:Bone Remodeling; D003198:Computer Simulation; D015444:Exercise / Q000502:physiology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D008954:Models, Biological; D015663:Osteoporosis, Postmenopausal / Q000517:prevention & control*