title: [A recurrent ovarian cancer patient who achieved a complete response following irinotecan plus CDDP therapy].
abstract: A 78-year-old patient had abdominal bloating since October 2002, and visited a GP, who noticed ascites, and referred the patient to our hospital. An exploratory laparotomy was performed and stage IIIc ovarian cancer was diagnosed. Six courses of docetaxel-carboplatin (DJ) chemotherapy were administered; however, the lesion was assessed as progressive disease (PD), and 24 courses of weekly paclitaxel were then administered. During the follow-up as an outpatient, a tumor marker increased again. Weekly paclitaxel was not effective this time, and the lesion was assessed as PD. The patient therefore received treatment with irinotecan and cisplatin (CPT-11+CDDP). These drugs have different mechanisms of action. The CA 125 level returned to normal following four courses of CPT-11+CDDP. The patient received a total of six courses, and thus far, no obvious recurrent lesion has been observed. These results suggest that CPT-11+CDDP may be effective against recurrent ovarian cancer, which is difficult to treat due to its resistance to platinum drugs and taxane drugs.
authors.affiliation: Dept. of Obstetrics and Gynecology, Fujieda Municipal General Hospital.
authors.forename: Tadahisa
authors.initials: T
authors.lastname: Kawashima
authors.forename: Hirotake
authors.initials: H
authors.lastname: Murakami
authors.forename: Takashi
authors.initials: T
authors.lastname: Kanamori
authors.forename: Yuki
authors.initials: Y
authors.lastname: Nakamura
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D014408:Biomarkers, Tumor / Q000097:blood; D001952:Bridged-Ring Compounds / Q000494:pharmacology; D018394:CA-125 Antigen / Q000097:blood; D002166:Camptothecin / Q000008:administration & dosage / Q000031:analogs & derivatives; D018269:Carcinoma, Endometrioid / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology; D002945:Cisplatin / Q000008:administration & dosage; D004333:Drug Administration Routes; D019008:Drug Resistance, Neoplasm; D005260:Female; D006801:Humans; D000077146:Irinotecan; D007813:Laparotomy; D010051:Ovarian Neoplasms / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology; D017239:Paclitaxel / Q000494:pharmacology; D012074:Remission Induction; D043823:Taxoids / Q000494:pharmacology
chemical_list: D014408:Biomarkers, Tumor; D001952:Bridged-Ring Compounds; D018394:CA-125 Antigen; D043823:Taxoids; C080625:taxane; D000077146:Irinotecan; D017239:Paclitaxel; D002945:Cisplatin; D002166:Camptothecin