Multimodal approaches to the management of neuropathic pain: the role of topical analgesia.
Because of their localized activity and low systemic absorption, topical analgesics have a favorable safety profile and a low risk for drug-drug interactions. There is a growing body of evidence on the efficacy and safety of these agents in a variety of pain disorders, including the most prevalent neuropathic pain conditions. The molecular basis for the usage of peripheral analgesics in neuropathic pain and the available clinical trial evidence for a wide variety of topical agents are reviewed.
de Leon-Casasola
Oscar A
OA
Department of Anesthesiology and Critical Care Medicine, Roswell Park Cancer Institute, School of Medicine and Biomedical Studies, State University of New York at Buffalo, Buffalo, New York 14263, USA. oscar.deleon@roswellpark.org
D000287:Administration, Topical; D000700:Analgesics / Q000008:administration & dosage*; D003131:Combined Modality Therapy; D006801:Humans; D009437:Neuralgia / Q000503:physiopathology / Q000628:therapy*
D000700:Analgesics