Gatifloxacin induced abnormalities in glucose homeostasis in a patient on glimepiride.
Gatifloxacin, a commonly prescribed antimicrobial can produce profound hypoglycemia and disturbances in glucose homeostasis especially in diabetes patients on sulphonylureas. Also new onset disturbances in glucose homeostasis can occur in patients who were unaffected by the previous use of gatifloxacin. Therefore it is suggested that gatifloxacin is better avoided in patients with diabetes and in the elderly.
Kesavadev
J
J
Jothydev's Diabetes and Research Center, Kerala.
Rasheed
S A
SA
D000890:Anti-Infective Agents / Q000009:adverse effects*; D001786:Blood Glucose / Q000187:drug effects*; D003920:Diabetes Mellitus / Q000188:drug therapy*; D005260:Female; D024841:Fluoroquinolones / Q000009:adverse effects*; D000077734:Gatifloxacin; D006706:Homeostasis / Q000187:drug effects; D006801:Humans; D006943:Hyperglycemia / Q000139:chemically induced*; D007003:Hypoglycemia / Q000139:chemically induced*; D008875:Middle Aged; D013453:Sulfonylurea Compounds / Q000494:pharmacology* / Q000627:therapeutic use
D000890:Anti-Infective Agents; D001786:Blood Glucose; D024841:Fluoroquinolones; D013453:Sulfonylurea Compounds; C057619:glimepiride; D000077734:Gatifloxacin