title: [Theoretical evaluation of the use of KT/Vurea and Ccr as indexes of peritoneal dialysis adequacy].
abstract: Urea clearance index (KT/Vurea) and creatinine clearance weekly (Ccr) are main indexes to evaluate dialysis adequacy. In order to discuss whether they are suitable to evaluate peritoneal dialysis adequacy, we applied trans-peritoneum transport kinetic model and explored the transport characteristics of fluid and various solutes. We found that: (1) There was no specific relationship among the removal of solutes with different molecular weights; (2) There was significant difference between urea removal and fluid and sodium removal. Our results suggest that urea and creatinine removal do not represent other solutes and fluid removal. KT/Vurea and Ccr may thus not suit to be used alone to evaluate peritoneal dialysis adequacy.
authors.affiliation: Institute of Nephrology, First Hospital, Peking University, Beijing 100034, China.
authors.forename: Yisheng
authors.initials: Y
authors.lastname: Shan
authors.forename: Xinkui
authors.initials: X
authors.lastname: Tian
authors.forename: Tao
authors.initials: T
authors.lastname: Wang
mesh_terms: D015415:Biomarkers / Q000378:metabolism; D001806:Blood Urea Nitrogen; D003404:Creatinine / Q000378:metabolism*; D006801:Humans; D010531:Peritoneal Dialysis, Continuous Ambulatory; D014508:Urea / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D014508:Urea; D003404:Creatinine