A critical overview of the pharmacologic management of treatment-resistant depression.
Major depressive disorder is a frequent, serious disorder that usually responds partially to treatment and leaves many patients with treatment resistance. This article reviews and critically evaluates the evidence for the management of treatment-resistant depression and examines pharmacologic approaches to alleviate the suffering of patients who benefit insufficiently from initial treatment.
Nierenberg
Andrew A
AA
Depression Clinical and Research Program, Massachusetts General Hospital, 50 Staniford Street, Boston, MA 02114, USA. anierenberg@partners.org
Katz
Judith
J
Fava
Maurizio
M
D000928:Antidepressive Agents / Q000493:pharmacokinetics* / Q000627:therapeutic use; D003865:Major Depressive Disorder / Q000175:diagnosis / Q000188:drug therapy / Q000628:therapy*; D004351:Drug Resistance; D006801:Humans; D011613:Psychotherapy
D000928:Antidepressive Agents