[Study on Helicobacter infection in liver tissue from hepatocellular carcinoma].
OBJECTIVE
To investigate the relationship between Helicobacter species and hepatocellular carcinoma(HCC).


METHODS
Liver samples resected during operation from 34 patients with HCC diagnosed by histopathology and 20 without primary liver carcinoma as controls were studied. The two groups of sample were cranked out pathologic slice for in situ hybridization of Helicobacter, Helicobacter pylori and Helicobacter hepaticus. Qualitative and quantitative studies were used to assess the correlation of liver tissue Helicobacter infection with HCC.


RESULTS
64.71% (22/34). of the samples of HCC showed positive for Helicobacter specific 16S rRNA-mRNA gene by in situ hybridization, while none was positive in controls (P < 0.01).


CONCLUSIONS
Helicobacter pylori were found in the liver of patients with HCC.
Li
Ning
N
Qingdao Municipal Hospital, Qingdao 266071, China.
Zhang
Shu-hui
SH
Xuan
Shi-ying
SY
Qiang
Xin
X
D006528:Carcinoma, Hepatocellular / Q000382:microbiology*; D016022:Case-Control Studies; D016481:Helicobacter Infections / Q000150:complications*; D044923:Helicobacter hepaticus / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D017403:In Situ Hybridization; D008099:Liver / Q000382:microbiology; D008113:Liver Neoplasms / Q000382:microbiology*