Host innate immune response to Mycobacterium tuberculosis.
This review focuses on recent progress in our understanding of Mycobacterium tuberculosis survival in macrophages, the interaction of M. tuberculosis with Toll-like receptors (TLRs) and the establishment of the link between innate and adaptive immunity, and TLRs and interferon-gamma-mediated antimicrobial pathways in macrophages. We also propose a paradigm that TLR2 signaling regulates the magnitude of the host Th1 response leading to either M. tuberculosis persistence and latent infection or replication and disease.
Bhatt
Kamlesh
K
Department of Medicine, Centre for Emerging Pathogens, UMDNJ-New Jersey Medical School, Newark, New Jersey 07101, USA.
Salgame
Padmini
P
D054884:Host-Pathogen Interactions; D006801:Humans; D007110:Immunity, Active; D007113:Immunity, Innate; D008264:Macrophages / Q000276:immunology*; D009169:Mycobacterium tuberculosis / Q000276:immunology*; D051193:Toll-Like Receptors / Q000502:physiology
D051193:Toll-Like Receptors