Evaluation of clinical efficacy of three different insemination techniques in couple infertility. A randomized study.
OBJECTIVE
The aim of the study was to compare the clinical results and efficiency of three insemination technique: intraperitoneal insemination (IPI), fallopian sperm perfusion (FSP) and intrauterine insemination (IUI).


METHODS
The experimental design was a prospective, randomized trial. A total of 101 homologous insemination cycles were performed in 71 consecutive couples with unexplained or male subfertility. Couples were randomized to receive IPI or FSP or IUI by predefined tables of randomization and each couple was submitted to the same insemination technique. The primary outcome of the study was the achievement of clinical pregnancy.


RESULTS
The results of the study underlined firstly that basal couple composition was not statistically different between the three groups. Moreover, no significant difference in clinical pregnancy rate was observed, despite a clearly positive trend for FSP, especially for unexplained infertility.


CONCLUSIONS
Our results showed that the three techniques of insemination IUI, FSP and IPI have similar efficacy on the achievement of clinical pregnancy in couples affected by longstanding infertility.
Noci
I
I
Department of Gynecology, Perinatology and Human Reproduction, University of Florence, Viale Morgagni 84, Florence, Italy. ivo.noci@unifi.it
Dabizzi
S
S
Evangelisti
P
P
Cozzi
C
C
Cameron Smith
M
M
Criscuoli
L
L
Fuzzi
B
B
Branconi
F
F
D005260:Female; D006801:Humans; D007248:Infertility, Male; D007315:Insemination, Artificial / Q000379:methods*; D008297:Male; D011247:Pregnancy / Q000706:statistics & numerical data; D011446:Prospective Studies