title: Comparison of coronary drug-eluting stents versus coronary artery bypass grafting in patients with diabetes mellitus.
abstract: We compared 1-year outcome after drug-eluting stent (DES) implantation with off-pump bypass grafing (OPCABG) in patients with type 2 diabetes mellitus and multivessel coronary artery disease involving the proximal segment of the left anterior descending coronary artery. All consecutive diabetic patients treated by DES (DES group) or OPCABG (CABG group) in our institution from April 2002 to December 2004 because of de novo coronary lesions were included. Patients in the CABG group (n = 149) were older and had a higher rate of 3-vessel disease than those in the DES group (n = 69). At 12 months, major adverse cardiac and cerebrovascular events occurred in 29% of the DES group and 20.5% of the CABG group (unadjusted analysis, odds ratio 1.20, 95% confidence interval [CI] 0.93 to 1.54, p = 0.17). After propensity score analysis, adjusting for baseline differences between the 2 cohorts, DESs increased the risk of 12-month major adverse cardiac and cerebrovascular events (hazard ratio 1.88, 95% CI 1.09 to 3.02, p = 0.020). This was due to the higher rate for repeat revascularization in the DES group (19% vs 5%, odds ratio 2.05, 95% CI 1.12 to 3.75, p = 0.001). In contrast, there was no difference in the rate of the composite end points of death, myocardial infarction, and stroke (DES group 13%, CABG group 12%; adjusted analysis, hazard ratio 0.80, 95% CI 0.80 to 1.35, p = 0.40). In conclusion, at 1 year in diabetic patients with multivessel coronary artery disease involving the proximal left anterior descending coronary artery, the advantage of OPCABG over DES implantation seems to be limited at a lower rate of repeat revascularization. No difference seems to exist in the rate of death, stroke, and myocardial infarction.
authors.affiliation: Interventional Cardiology, Department of Cardiology, Clinica Mediterranea, Naples, Italy. briguori.carlo@hsr.it
authors.forename: Carlo
authors.initials: C
authors.lastname: Briguori
authors.forename: Gerolama
authors.initials: G
authors.lastname: Condorelli
authors.forename: Flavio
authors.initials: F
authors.lastname: Airoldi
authors.forename: Amelia
authors.initials: A
authors.lastname: Focaccio
authors.forename: Davide
authors.initials: D
authors.lastname: D'Andrea
authors.forename: Mario
authors.initials: M
authors.lastname: Cannavale
authors.forename: Alireza Afzali
authors.initials: AA
authors.lastname: Abarghouei
authors.forename: Salvatore
authors.initials: S
authors.lastname: Giordano
authors.forename: Fabrizio
authors.initials: F
authors.lastname: De Vivo
authors.forename: Bruno
authors.initials: B
authors.lastname: Ricciardelli
authors.forename: Antonio
authors.initials: A
authors.lastname: Colombo
mesh_terms: D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D017023:Coronary Angiography; D001026:Coronary Artery Bypass; D003324:Coronary Artery Disease / Q000150:complications / Q000601:surgery / Q000628:therapy*; D023903:Coronary Restenosis / Q000000981:diagnostic imaging / Q000401:mortality*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications*; D003930:Diabetic Retinopathy / Q000473:pathology; D018572:Disease-Free Survival; D016503:Drug Delivery Systems; D005260:Female; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D015607:Stents; D016019:Survival Analysis; D016896:Treatment Outcome