Effect of peroxisome proliferator-activated receptor alpha ligand fenofibrate on K(v) channels in the insulin-secreting cell line HIT-T15.
Ligands for peroxisome proliferator-activated receptors alpha (PPARalpha) are clinically used for the treatment of patients with hyperlipidemia. As we have previously shown, a synthetic ligand of PPARalpha, fenofibrate, has a stimulatory effect on insulin secretion in clonal hamster insulinoma beta-cell line HIT-T15 cells. We have also demonstrated that fenofibrate directly inhibits ATP-sensitive potassium (K(ATP)) channels, an effect independent of PPARalpha. In this study, fenofibrate was shown to be able to reduce voltage-dependent K(+) (K(v)) channel currents in voltage-independent manner. Therefore, fenofibrate may modulate insulin secretion not only via inhibition of K(ATP) channels but also via reduction of the K(v) channel current.
Shimomura
K
K
University Laboratory of Physiology, Parks Road, Oxford OX1 3PT, United Kingdom. kenju.shimomura@physiol.ox.ac.uk
Ikeda
M
M
Ariyama
Y
Y
Proks
P
P
Shimomura
Y
Y
Mori
M
M
Matsumoto
S
S
D000818:Animals; D002460:Cell Line; D006224:Cricetinae; D004305:Dose-Response Relationship, Drug; D011345:Fenofibrate / Q000008:administration & dosage*; D050417:Insulin-Secreting Cells / Q000187:drug effects* / Q000502:physiology*; D015640:Ion Channel Gating / Q000187:drug effects / Q000502:physiology*; D047493:PPAR alpha / Q000037:antagonists & inhibitors*; D015221:Potassium Channels / Q000187:drug effects* / Q000502:physiology*
D047493:PPAR alpha; D015221:Potassium Channels; D011345:Fenofibrate