[Free aminoacids and cerebral lipids in the rat following porto-cava anastomosis].
Free aminoacids and cerebral lipids were studied in rats following porto-cava anastomosis with total deviation of the portal flow. No difference in lipid pattern with respect to the controls was noted after 1 month. Changes in free aminoacids, however, were observed, including a significant increase in gamma-aminobutyric acid (GABA) and a significant decrease in glutamic acid. The meaning of these results with respect to the pathogenesis of porto-cava encephalopathy is discussed.
Vassanelli
P
P
Istituto di Patologia Speciale Chirurgica e Propedeutica Clinica dell'Università di Padova.
Stella
G D
GD
Pelizzo
M R
MR
Rizzi
B
B
Bertani
G
G
D000596:Amino Acids / Q000032:analysis*; D000818:Animals; D001923:Brain Chemistry; D018698:Glutamic Acid / Q000032:analysis; D006501:Hepatic Encephalopathy / Q000209:etiology / Q000378:metabolism*; D008055:Lipids / Q000032:analysis*; D008297:Male; D010743:Phospholipids / Q000032:analysis; D011167:Portacaval Shunt, Surgical / Q000009:adverse effects*; D011183:Postoperative Complications / Q000209:etiology / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D005680:gamma-Aminobutyric Acid / Q000032:analysis
D000596:Amino Acids; D008055:Lipids; D010743:Phospholipids; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid