The sunny side of p53.
Skin, the largest organ of our body, is often plagued by cancer because of exposure to ultraviolet radiation from the sun. A report by Cui et al. (2007) in this issue of Cell explains how the tumor suppressor p53 protects the skin by stimulating the suntan response.
Oren
Moshe
M
Department of Molecular Cell Biology, Weizmann Institute, Rehovot, Israel.
Bartek
Jiri
J
D000818:Animals; D004249:DNA Damage; D016158:Genes, p53; D006801:Humans; D015603:Keratinocytes / Q000378:metabolism / Q000528:radiation effects; D008543:Melanins / Q000096:biosynthesis; D008544:Melanocytes / Q000378:metabolism / Q000528:radiation effects; D051379:Mice; D011333:Pro-Opiomelanocortin / Q000235:genetics / Q000378:metabolism; D012867:Skin / Q000378:metabolism* / Q000528:radiation effects*; D012878:Skin Neoplasms / Q000235:genetics; D012880:Skin Pigmentation; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*; D014466:Ultraviolet Rays / Q000009:adverse effects*; D000521:alpha-MSH / Q000235:genetics
D008543:Melanins; D016159:Tumor Suppressor Protein p53; D000521:alpha-MSH; D011333:Pro-Opiomelanocortin