Antibody-catalyzed oxidation of delta(9)-tetrahydrocannabinol.
Marijuana abuse continues to plague society and the lack of effective treatments warrants concern. Catalytic antibodies capable of oxidatively degrading the major psychoactive component of marijuana, Delta9-tetrahydrocannabinol (Delta9-THC), are presented. The antibodies generate reactive oxygen species from singlet oxygen (1O2*), using riboflavin (vitamin B2) and visible light as the 1O2* source. Cannabitriol was identified as the major degradation product of this reaction, demonstrating the ability of an antibody to catalyze a complex chemical transformation with therapeutic implications for treating marijuana abuse.
Brogan
Andrew P
AP
Department of Chemistry, The Skaggs Institute for Chemical Biology, Worm Institute for Research and Medicine, and the Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, California 92037, USA.
Eubanks
Lisa M
LM
Koob
George F
GF
Dickerson
Tobin J
TJ
Janda
Kim D
KD
D000906:Antibodies / Q000737:chemistry*; D002384:Catalysis; D013759:Dronabinol / Q000737:chemistry*; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010084:Oxidation-Reduction
D000906:Antibodies; D013759:Dronabinol