Low-valent niobium-catalyzed reduction of alpha,alpha,alpha-trifluorotoluenes.
[reaction: see text] In the presence of 5 mol % of niobium(V) chloride, alpha,alpha,alpha-trifluorotoluene derivatives were reduced with lithium aluminum hydride to give toluene derivatives in good yields. Stepwise, partial reduction of bis(trifluoromethyl)benzene derivative was also demonstrated.
Fuchibe
Kohei
K
Department of Chemistry, Faculty of Science, Gakushuin University, 1-5-1 Mejiro Toshima-ku, Tokyo 171-8588, Japan.
Ohshima
Yoshitaka
Y
Mitomi
Ken
K
Akiyama
Takahiko
T