title: CD13 and TCR clone: markers of early mycosis fungoides.
abstract: Making a differential diagnosis between early mycosis fungoides and parapsoriasis is often difficult at the clinical and histological level. The aim of this study was to explore markers that could help in this process. A total of 88 patients were included in 2 categories: large plaque parapsoriasis and digitiform parapsoriasis. A histological examination was performed for each patient, and expression of the antigen My7 (CD13), which is lacking in cutaneous T-lymphomas (but not in inflammatory lesions) and rearrangement of the T-cell receptor gene were analysed. A histological aspect of epidermotropic cutaneous T-cell lymphoma was observed in 23.5% of cases of large plaque parapsoriasis and 15% of cases of digitiform parapsoriasis. A disappearance of My7 antigen was noted in the 2 forms of parapsoriasis, more frequently when there was cutaneous T-cell lymphoma histology. A cutaneous clone was observed in 10.3% of cases of large plaque parapsoriasis, but not of digitiform parapsoriasis. For 3 patients, a cutaneous clone and a disappearance of My7 were associated with a non-specific histology. Considering these histological, immunological and molecular biological data, it appears that My7 antigen combined with T-cell clone may help the dermatologist to confirm the diagnosis of early mycosis fungoides. Moreover, further studies will determine whether CD13 is an early prognostic marker of evolution of a parapsoriasis to mycosis fungoides. Finally, these results demonstrate that digitiform parapsoriasis can be an early stage of MF.
authors.affiliation: Unit of Skin Oncology, Hôtel Dieu, Place Alexis Ricordeau, Nantes, France.
authors.forename: Claire
authors.initials: C
authors.lastname: Bernier
authors.forename: Jean Michel
authors.initials: JM
authors.lastname: Nguyen
authors.forename: Gaëlle
authors.initials: G
authors.lastname: Quéreux
authors.forename: Jean Jaques
authors.initials: JJ
authors.lastname: Renault
authors.forename: Brigine
authors.initials: B
authors.lastname: Bureau
authors.forename: Brigitte
authors.initials: B
authors.lastname: Dreno
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018826:CD13 Antigens / Q000096:biosynthesis* / Q000235:genetics; D005260:Female; D015321:Gene Rearrangement; D019672:Genes, T-Cell Receptor; D006801:Humans; D016410:Lymphoma, T-Cell, Cutaneous / Q000235:genetics / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009182:Mycosis Fungoides / Q000235:genetics / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D010267:Parapsoriasis / Q000235:genetics / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D011948:Receptors, Antigen, T-Cell / Q000096:biosynthesis* / Q000235:genetics
chemical_list: D011948:Receptors, Antigen, T-Cell; D018826:CD13 Antigens