title: Predictors of response to bronchial allergen challenge in 5- to 6-year-old atopic children.
abstract: BACKGROUND
  The relationship between atopy and bronchial allergy in young children is not completely understood.
  
  
  OBJECTIVE
  To examine the association between response to bronchial allergen challenge, immune markers of atopy and other clinical characteristics in 5- to 6-year-old children.
  
  
  METHODS
  Children with positive skin test (SPT) to aeroallergen, together with a proportion of SPT negative children (as controls), were recruited from a birth cohort of 198 children at high risk of developing atopic disease and underwent allergen challenge.
  
  
  RESULTS
  Thirty-seven children (26 atopic and 11 SPT negative), median age 74.5 months, were challenged: 31 with house dust mite and six with grass allergen. Only atopic children responded to challenge: n = 12/26 (46%). Wheal size [odds ratio (OR) 2.5 (1.2-5.3), P = 0.01], allergen-specific immunoglobulin E (IgE) [OR 3.4 (1.23-9.61), P = 0.02], total IgE [OR 8.6 (1.1-68.7), P = 0.04], current wheeze [OR 12 (1.7-81.7), P = 0.006] and persistent eczema [OR 11.0 (1.7-68.3), P = 0.006] emerged as the strongest independent predictors of response to allergen challenge. Prediction of response to allergen challenge was significantly improved when immune markers of atopy, and in particular wheal size, were combined with clinical characteristics.
  
  
  CONCLUSIONS
  The relationship between atopy and bronchial allergy is quantitative at this age. There may be potential to create more powerful indicators of the presence of respiratory allergy in young children when immunological markers of atopy are considered quantitatively and when combined with clinical history of coexistent allergic disease.
authors.affiliation: Division of Clinical Sciences, Telethon Institute for Child Research, Centre for Child Health Research, The University of Western Australia, Perth, WA, Australia.
authors.forename: T A
authors.initials: TA
authors.lastname: Douglas
authors.forename: M
authors.initials: M
authors.lastname: Kusel
authors.forename: E M
authors.initials: EM
authors.lastname: Pascoe
authors.forename: R K S
authors.initials: RK
authors.lastname: Loh
authors.forename: P G
authors.initials: PG
authors.lastname: Holt
authors.forename: P D
authors.initials: PD
authors.lastname: Sly
mesh_terms: D000485:Allergens / Q000008:administration & dosage* / Q000276:immunology; D001985:Bronchial Provocation Tests; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000097:blood / Q000453:epidemiology / Q000276:immunology*; D007073:Immunoglobulin E / Q000097:blood / Q000276:immunology; D008297:Male; D012882:Skin Tests
chemical_list: D000485:Allergens; D007073:Immunoglobulin E