Regulation of postprandial lipemia: an update on current trends.
People spend a large percentage of their waking hours in the postprandial state. Postprandial lipemia is associated with disruptions in lipoprotein metabolism and inflammatory factors, cardiovascular disease, MetS, and diabetes. Commonly, the dietary sources of fat exceed the actual needs and the tissues are faced with the excess, with accumulation of chylomicrons and remnant particles. This review will summarize recent findings in postprandial lipemia research with a focus on human studies. The effects of dietary factors and other meal components on postprandial lipemia leads to the following question: do we need a standardized oral lipid tolerance test (OLTT)? An overview of recent findings on FABP2, MTP, LPL, apoAV, and ASP and the effects of body habitus (sex influence and body size), as well as exercise and weight loss, on postprandial lipemia will be summarized.
Paglialunga
Sabina
S
McGill University, Department of Biochemistry, Montreal, QC H3G 1Y6, Canada.
Cianflone
Katherine
K
D000818:Animals; D002318:Cardiovascular Diseases / Q000097:blood / Q000209:etiology; D004032:Diet; D004041:Dietary Fats / Q000009:adverse effects / Q000097:blood; D015444:Exercise; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood / Q000150:complications; D007333:Insulin Resistance; D008297:Male; D051379:Mice; D019518:Postprandial Period; D014280:Triglycerides / Q000009:adverse effects / Q000097:blood
D004041:Dietary Fats; D014280:Triglycerides