[Overlap syndrome autoimmune hepatitis and primary biliary cirrhosis associated with antiphospholipid syndrome].
The paper presents diagnostic problems and therapeutic management in a case of 34 year old woman with antiphospholipid syndrome (APS) connected with overlap syndrome: autoimmune hepatitis (AIH) and primary biliary cirrhosis (PBC). Life threatening cardiac arrhythmia was the first clinical manifestation of the disease. Pulmonary embolism occurred a few months later, with the presence of antiphospholipid antibodies. The diagnosis of AlH and PBC was made as a result of further research of complex immunological disturbances observed in the patient and after liver biopsy.
Targońska-Stepniak
Bozena
B
Department of Rheumatology and Connective Tissue Diseases, Medical University of Lublin, Poland. bozena.stepniak@am.lublin.pl
Majdan
Maria
M
Suszek
Dorota
D
Laskowska
Katarzyna
K
D000328:Adult; D000974:Antibodies, Antinuclear / Q000097:blood; D016736:Antiphospholipid Syndrome / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D001145:Arrhythmias, Cardiac / Q000150:complications / Q000175:diagnosis* / Q000276:immunology / Q000628:therapy; D001323:Autoantibodies / Q000097:blood*; D001327:Autoimmune Diseases / Q000145:classification / Q000175:diagnosis*; D001379:Azathioprine / Q000008:administration & dosage / Q000627:therapeutic use; D001706:Biopsy; D003937:Diagnosis, Differential; D005260:Female; D019693:Hepatitis, Autoimmune / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008099:Liver / Q000473:pathology; D008105:Liver Cirrhosis, Biliary / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D009102:Multiple Organ Failure / Q000145:classification / Q000175:diagnosis*; D011239:Prednisolone / Q000627:therapeutic use; D013577:Syndrome; D016896:Treatment Outcome
D000974:Antibodies, Antinuclear; D001323:Autoantibodies; D007166:Immunosuppressive Agents; D011239:Prednisolone; D001379:Azathioprine