Similar effects of clozapine and olanzapine on ethanol-induced ascorbic acid release in the prefrontal cortex of freely moving mice.
Previous studies have shown that acute systemic administration of ethanol induced ascorbic acid (AA) release in mouse striatum and prefrontal cortex. Clozapine and olanzapine showed similar effects on ethanol-induced AA release in mouse striatum. However, their effects on ethanol-induced AA release in mouse prefrontal cortex have not been reported. Thus, their effects on this neurochemical event were further investigated in the present study. The results showed that ethanol (4.0 gkg i.p.) significantly stimulated AA release in the prefrontal cortex by about 200 of baseline in mice. Clozapine and olanzapine, at the dose of 1.0 mgkg s.c., had no effect on basal AA or ethanol-induced AA release. However, both drugs, at the dose of 10 mgkg s.c., significantly inhibited ethanol-induced AA release. The present study demonstrated for the first time that similar actions were exhibited by clozapine and olanzapine for the regulation of ethanol-induced AA release in the mouse prefrontal cortex.
Hou
Yue
Y
Department of Pharmacology, Shenyang Pharmaceutical University, Wenhua Road 103, Shenyang 110016, PR China.
Wu
Chun Fu
CF
Yang
Jing Yu
JY
Gu
Pei Fei
PF
Bi
Xiu Li
XL
Dai
Fang
F
D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000378:metabolism*; D001569:Benzodiazepines / Q000494:pharmacology; D002492:Central Nervous System Depressants / Q000494:pharmacology*; D003024:Clozapine / Q000494:pharmacology*; D000431:Ethanol / Q000494:pharmacology*; D008297:Male; D051379:Mice; D017551:Microdialysis; D000077152:Olanzapine; D017397:Prefrontal Cortex / Q000187:drug effects / Q000378:metabolism*
D014150:Antipsychotic Agents; D002492:Central Nervous System Depressants; D001569:Benzodiazepines; D000431:Ethanol; D003024:Clozapine; D000077152:Olanzapine; D001205:Ascorbic Acid