title: Homozygous factor V Leiden mutation and disseminated thrombosis in a patient with nephrotic syndrome.
abstract: We report the case of a young male patient with nephrotic syndrome and multiple venous thromboses. The patient presented various aggregated thrombophilic risk factors. He was found to be homozygous for factor V Leiden mutation and his anticardiolipin antibody and homocysteine levels were high. The association between nephrotic syndrome and venous thrombosis is well known. However the presence of disseminated thrombosis should prompt an intensive work-up for the detection of thrombotic risk factors and aggressive anticoagulant therapy.
authors.affiliation: Division of Nephrology, Department of Internal Medicine, Cerrahpasa Medical Faculty, Istanbul University, Istanbul - Turkey.
authors.forename: Arzu
authors.initials: A
authors.lastname: Kahveci
authors.forename: Nurhan
authors.initials: N
authors.lastname: Seyahi
authors.forename: Emire
authors.initials: E
authors.lastname: Seyahi
authors.forename: Mehmet R
authors.initials: MR
authors.lastname: Altiparmak
authors.forename: Rezzan
authors.initials: R
authors.lastname: Ataman
authors.forename: Kamil
authors.initials: K
authors.lastname: Serdengecti
mesh_terms: D000328:Adult; D017153:Antibodies, Anticardiolipin / Q000097:blood; D000925:Anticoagulants / Q000627:therapeutic use; D025861:Blood Coagulation Disorders, Inherited / Q000188:drug therapy / Q000235:genetics; D004211:Disseminated Intravascular Coagulation / Q000188:drug therapy / Q000235:genetics; D005165:Factor V / Q000235:genetics*; D006710:Homocysteine / Q000097:blood; D006720:Homozygote; D006801:Humans; D008297:Male; D009154:Mutation / Q000235:genetics*; D009404:Nephrotic Syndrome / Q000150:complications*; D012307:Risk Factors; D020246:Venous Thrombosis / Q000188:drug therapy / Q000235:genetics*
chemical_list: D017153:Antibodies, Anticardiolipin; D000925:Anticoagulants; C095381:factor V Leiden; D006710:Homocysteine; D005165:Factor V