[Effectiveness and safety of transdermal buprenorphine for chronic pain treatment in the elderly: a prospective observational study].
OBJECTIVE
A number of subjects aged over 65 suffer from some kind of chronic pain. The constant growth of this demographic group makes research of new and efficacious treatment strategies necessary. Transdermal buprenorphine has shown to be a safe and efficacious pharmacotherapy for patients with moderate to severe chronic pain in clinical trials. This paper provides the outcome of this drug in routine clinical practice.


METHODS
A prospective, uncontrolled observational study that included a 3-month follow-up of patients starting transdermal buprenorphine was performed. Information was collected systematically on pain relief, quality of life (EuroQol-5D questionnaire), comfort of patch use and adverse events. Missing data were imputed by the <<worst case>>.


RESULTS
Out of 1,188 patients with known age, 564 were under 65, 337 were between 65 and 75, and 287 were over 75 years. Within these respective age groups, 63.9%, 66.3% and 67.7% of patients showed <<good>> or <<very good>> pain relief; 60.4%, 60.7% and 65.2% showed improvement of sleep quality; and the mean increases of the score of the EuroQol-5D visual analogue scale were 16.0 mm, 15.8 mm and 16.8 mm. Drug-related adverse events were reported in 39.6%, 35.4% and 31.9% of patients, respectively.


CONCLUSIONS
This study performed in the routine-care setting supports the findings from previous randomised controlled clinical trials of transdermal buprenorphine.
Muriel Villoria
Clemente
C
Unidad del Dolor, Servicio de Anestesia, Hospital Clínico de Salamanca, Salamanca, España.
Pérez-Castejón Garrote
Juan Manuel
JM
Sánchez Magro
Isabel
I
Neira Alvarez
Marta
M
D000279:Administration, Cutaneous; D000368:Aged; D000701:Analgesics, Opioid / Q000008:administration & dosage*; D002047:Buprenorphine / Q000008:administration & dosage*; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000188:drug therapy*; D011446:Prospective Studies
D000701:Analgesics, Opioid; D002047:Buprenorphine