title: Differentiation of stenosed and aneurysmal arteries by pulse wave propagation analysis based on a fluid-solid interaction computational method.
abstract: Pulse Wave Velocity (PWV) is recognized by clinicians as an index of the mechanical properties of human blood vessels. However, the measured PWV of real human blood vessels will not always obey the Moens-Korteweg equation, which describes the PWV in ideal elastic tubes. Waveform analysis has been studied as an alternative diagnosis for cardiovascular disease, and reflected waves that occur in the diseased region may be a key for the estimation of the severity of disease. In this study, we modeled stenosed and aneurysmal arteries in a three-dimensional coupled fluid-solid interaction scheme, and analyzed the pulse wave propagation in order to assess the reflected waves that occurred in the diseased region. A commercial code (Radioss, MECALOG, France) was used to solve the fluid-solid interactions. A steady flow with Reynolds number 1000 was imposed at the inlet of the artery as the basic flow, then a single rectangular pulse with Reynolds number 4000 was imposed upon the basic flow to produce a propagating wave. We showed that the reflected waves from the stenosis and the aneurysm are different in their phase, and the wavelength of the reflected waves from the aneurysm is affected by the aneurysm length.
authors.affiliation: Department of Bioengineering and Robotics, Tohoku University, Graduate School of Engineering, Aoba 6-6-01, Aoba-ku, Sendai, Miyagi 980-8579, Japan. fukui@pfsl.mech.tohoku.ac.jp
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Fukui
authors.forename: Kim H
authors.initials: KH
authors.lastname: Parker
authors.forename: Ken-ichi
authors.initials: K
authors.lastname: Tsubota
authors.forename: Shigeo
authors.initials: S
authors.lastname: Wada
authors.forename: Takami
authors.initials: T
authors.lastname: Yamaguchi
mesh_terms: D001014:Aortic Aneurysm / Q000097:blood / Q000175:diagnosis* / Q000503:physiopathology; D001024:Aortic Valve Stenosis / Q000097:blood / Q000175:diagnosis* / Q000503:physiopathology; D001698:Biomedical Engineering; D001783:Blood Flow Velocity / Q000502:physiology*; D002318:Cardiovascular Diseases / Q000175:diagnosis* / Q000503:physiopathology; D004548:Elasticity; D006801:Humans; D008955:Models, Cardiovascular; D011673:Pulsatile Flow / Q000502:physiology*; D012720:Severity of Illness Index