title: Pharmacological Studies on Linderae umbellatae Ramus, IV*. Effects of Condensed Tannin Related Compounds on Peptic Activity and Stress-Induced Gastric Lesions in Mice.
abstract: Nine condensed tannin related compounds isolated from LINDERAE UMBELLATAE Ramus, (+)-catechin ( 1), (-)-epicatechin ( 2), proanthocyanidin B-1 ( 3), B-2 ( 4), B-4 ( 5), trimer A ( 6), trimer B ( 7), cinnamtannin B (1) ( 8) and cinnamtannin D (1) ( 9), were tested for their effects on peptic activity and stress-induced gastric lesions in mice. Peptic activity of rat gastric juice was suppressed by 6 and 7 IN VITRO, and slightly suppressed by 8 and 9. In pylorus-ligated mice, these compounds, except for 4, administered orally exhibited anti-peptic activity. Pretreatments of 4,6 and 7 orally protected mice against stress-induced gastric lesions. Effects of these compounds on digestive systems were dìscussed.
authors.affiliation: Central Research Laboratories, Yomeishu Seize Co. Ltd.
authors.forename: N
authors.initials: N
authors.lastname: Ezaki
authors.forename: M
authors.initials: M
authors.lastname: Kato
authors.forename: N
authors.initials: N
authors.lastname: Takizawa
authors.forename: S
authors.initials: S
authors.lastname: Morimoto
authors.forename: G
authors.initials: G
authors.lastname: Nonaka
authors.forename: I
authors.initials: I
authors.lastname: Nishioka