title: Mineralocorticoid receptor antagonists.
abstract: With an increasingly aging population, the need for effective treatment of cardiovascular diseases (eg, heart failure, hypertension, and ischemic heart disease) cannot be overemphasized. The vital importance of mineralocorticoid receptor antagonists for treating cardiovascular conditions has only been appreciated in the last decade. The re-emergence of mineralocorticoid receptor antagonists has provided clinicians with an important tool towards complete blockade of the renin-angiotensin-aldosterone axis.
authors.affiliation: Hypertension Research Centre, Division of Medicine & Therapeutics, Ninewells Hospital & Medical School, University of Dundee, Dundee, Scotland, DD1 9SY, UK.
authors.forename: Hari Krishnan
authors.initials: HK
authors.lastname: Parthasarathy
authors.forename: Thomas M
authors.initials: TM
authors.lastname: MacDonald
mesh_terms: D000818:Animals; D002191:Canrenoic Acid / Q000494:pharmacology / Q000627:therapeutic use; D002318:Cardiovascular Diseases / Q000188:drug therapy; D000077545:Eplerenone; D006801:Humans; D000451:Mineralocorticoid Receptor Antagonists / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use*; D012084:Renin-Angiotensin System / Q000187:drug effects; D013148:Spironolactone / Q000031:analogs & derivatives / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D000451:Mineralocorticoid Receptor Antagonists; D013148:Spironolactone; D000077545:Eplerenone; D002191:Canrenoic Acid