title: Expression of the CUB domain containing protein 1 (CDCP1) gene in colorectal tumour cells.
abstract: Expression of CUB domain containing protein 1 (CDCP1) is upregulated in carcinoma cells. We quantitated CDCP1 gene expression in matched normal colon and tumour tissue and compared the level of expression to other genes upregulated in colorectal tumourigenesis. Furthermore, we show that the CDCP1 gene generates two transcripts which are co-expressed in normal and matched tumour tissue as well as in the majority of cell lines analysed. However, intracellular localisation studies revealed that only one of these transcripts encodes a protein that is localised to the cell surface.
authors.affiliation: Institute of Molecular and Cellular Biology, Faculty of Biological Sciences, Garstang Building, Room 8.10a, University of Leeds, Leeds LS2 9JT, United Kingdom.
authors.forename: Sara E
authors.initials: SE
authors.lastname: Perry
authors.forename: Philip
authors.initials: P
authors.lastname: Robinson
authors.forename: Alan
authors.initials: A
authors.lastname: Melcher
authors.forename: Philip
authors.initials: P
authors.lastname: Quirke
authors.forename: Hans-Jörg
authors.initials: HJ
authors.lastname: Bühring
authors.forename: Graham P
authors.initials: GP
authors.lastname: Cook
authors.forename: G Eric
authors.initials: GE
authors.lastname: Blair
mesh_terms: D015703:Antigens, CD / Q000032:analysis* / Q000235:genetics; D000951:Antigens, Neoplasm; D015815:Cell Adhesion Molecules / Q000032:analysis* / Q000235:genetics; D045744:Cell Line, Tumor; D015179:Colorectal Neoplasms / Q000378:metabolism / Q000473:pathology*; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008565:Membrane Proteins; D009363:Neoplasm Proteins / Q000032:analysis* / Q000235:genetics; D012333:RNA, Messenger; D012334:RNA, Neoplasm; D015854:Up-Regulation / Q000235:genetics
chemical_list: D015703:Antigens, CD; D000951:Antigens, Neoplasm; C432044:CDCP1 protein, human; D015815:Cell Adhesion Molecules; D008565:Membrane Proteins; D009363:Neoplasm Proteins; D012333:RNA, Messenger; D012334:RNA, Neoplasm