Review: new biological insights in early clinical studies.
First in human phase I trials are an unaviodable gateway to the development of new anticancer therapies. The discovery of target therapies have significantly changed the process of clinical drug development.This short review will focus on the main features including knowledge of biological aspects, methodology and adequacy of design and of performance of early clinical studies.
Maur
Michela
M
Oncology and Haematology Department, University Study of Modena and Reggio Emilia, Italy.
Sessa
Cristiana
C
D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D017321:Clinical Trials, Phase I as Topic; D006801:Humans; D020714:Maximum Tolerated Dose; D009369:Neoplasms / Q000188:drug therapy*; D012107:Research Design
D000970:Antineoplastic Agents