[Changes in expression of apoptosis-associated molecules in hypothalamic neurosecretory cells of mice during aging].
The aim of work was to study the peculiarities of apoptosis regulation in neurosecretory centers of old (aged 18 months) mice treated with immunomodulator interferon alpha (IFN-alpha) as compared to young (aged 2 months) mice. It was shown that age-related apoptosis activation in supraoptic (SON) and paraventricular (PVN) nuclei was mediated by different molecular mechanisms and could result from the alterations of the balance of apoptosis-associated proteins, including the synthesis of proapoptotic (Bax) and antiapoptotic (Mcl-1, Bcl-2) molecules. Besides, the apoptosis signal cascade in young mice treated with IFN-alpha was identical in both nuclei, whereas in old mice there were some differences between SON and PVN.
Bazhanova
E D
ED
Molodtsov
V N
VN
Pavlov
K I
KI
D000375:Aging / Q000378:metabolism*; D000818:Animals; D017209:Apoptosis; D007031:Hypothalamus / Q000166:cytology / Q000378:metabolism*; D016898:Interferon-alpha / Q000494:pharmacology; D008297:Male; D051379:Mice; D064549:Myeloid Cell Leukemia Sequence 1 Protein; D009363:Neoplasm Proteins / Q000096:biosynthesis*; D009490:Neurosecretory Systems / Q000378:metabolism*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000096:biosynthesis*; D051028:bcl-2-Associated X Protein / Q000096:biosynthesis
D016898:Interferon-alpha; C579094:Mcl1 protein, mouse; D064549:Myeloid Cell Leukemia Sequence 1 Protein; D009363:Neoplasm Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D051028:bcl-2-Associated X Protein