title: JAK2V617F detection and dosage of serum erythropoietin: first steps of the diagnostic work-up for patients consulting for elevated hematocrit.
abstract: The predictive values of common biological criteria for the diagnosis of polycythemia vera were studied in a cohort of patients with high hematocrit. We found JAK2V617F and erythropoietin assays were the most relevant first tests. Classification of patients according to their JAK2V617F status and erythropoietin levels facilitated the choice of further diagnostic investigations.
authors.forename: François
authors.initials: F
authors.lastname: Girodon
authors.forename: Eric
authors.initials: E
authors.lastname: Lippert
authors.forename: Pascal
authors.initials: P
authors.lastname: Mossuz
authors.forename: Irène
authors.initials: I
authors.lastname: Dobo
authors.forename: Nathalie
authors.initials: N
authors.lastname: Boiret-Dupré
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Lesesve
authors.forename: Sylvie
authors.initials: S
authors.lastname: Hermouet
authors.forename: Vincent
authors.initials: V
authors.lastname: Praloran
mesh_terms: D019943:Amino Acid Substitution; D015331:Cohort Studies; D003937:Diagnosis, Differential; D004921:Erythropoietin / Q000097:blood*; D005260:Female; D005787:Gene Frequency; D006400:Hematocrit; D006801:Humans; D053614:Janus Kinase 2 / Q000097:blood / Q000235:genetics*; D008297:Male; D050505:Mutant Proteins / Q000097:blood / Q000235:genetics*; D020125:Mutation, Missense; D017354:Point Mutation; D011086:Polycythemia / Q000097:blood / Q000175:diagnosis; D011087:Polycythemia Vera / Q000097:blood / Q000175:diagnosis* / Q000201:enzymology / Q000235:genetics; D011237:Predictive Value of Tests
chemical_list: D050505:Mutant Proteins; D004921:Erythropoietin; C507924:JAK2 protein, human; D053614:Janus Kinase 2