title: A quantitative structure-activity relationship study on some novel series of hydroxamic acid analogs acting as matrix metalloproteinase inhibitors.
abstract: A quantitative structure-activity relationship study has been made on some pyranyl hydroxamic acid analogs acting as matrix metalloproteinase (MMP) inhibitors. The inhibition potencies of two different series of compounds against two MMP enzymes (MMP-1 and MMP-13) have been analyzed and found to be well correlated with hydrophobic and some indicator parameters of the substituents. In both the cases, hydrophobic parameter of substituents has been found to be a dominant factor. The results of this study led to discuss the selectivity of the compounds for MMP-13 over MMP-1.
authors.affiliation: Department of Pharmacy, Birla Institute of Technology and Science, Pilani-333031, India.
authors.forename: S
authors.initials: S
authors.lastname: Kumaran
authors.forename: S P
authors.initials: SP
authors.lastname: Gupta
mesh_terms: D055598:Chemical Phenomena; D002627:Chemistry, Physical; D006877:Hydroxamic Acids / Q000138:chemical synthesis* / Q000494:pharmacology*; D007202:Indicators and Reagents; D007527:Isoenzymes / Q000037:antagonists & inhibitors; D061965:Matrix Metalloproteinase Inhibitors; D011480:Protease Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D021281:Quantitative Structure-Activity Relationship
chemical_list: D006877:Hydroxamic Acids; D007202:Indicators and Reagents; D007527:Isoenzymes; D061965:Matrix Metalloproteinase Inhibitors; D011480:Protease Inhibitors