DNA damage of human spermatozoa in assisted reproduction: origins, diagnosis, impacts and safety.
Sperm DNA contributes half the offspring's genomic material and abnormal DNA can lead to derangements in the reproductive process. Normal sperm genetic material is required for successful fertilization, as well as for further embryo and fetal development that will result in a healthy child. Thus, the damage to sperm DNA is critical in assisted reproductive techniques which are increasingly used to treat infertile couples. There has been improving data about the effects of human sperm DNA damage or fragmentation. As well, increasing knowledge concerning the effects of DNA damage on embryo and fetal development has been attained. This review aims to summarize the present knowledge on the impact of human sperm cell DNA damage on male infertility and outcome in the context of safety.
Ozmen
B
B
Department of Obstetrics and Gynecology, University of Ankara, Ankara, Turkey.
Koutlaki
N
N
Youssry
M
M
Diedrich
K
K
Al-Hasani
S
S
D002843:Chromatin / Q000378:metabolism; D004247:DNA / Q000378:metabolism; D004249:DNA Damage; D005260:Female; D005306:Fertilization; D006801:Humans; D008297:Male; D018384:Oxidative Stress; D011247:Pregnancy; D011256:Pregnancy Outcome; D017382:Reactive Oxygen Species; D027724:Reproductive Techniques, Assisted; D012661:Semen / Q000378:metabolism; D013094:Spermatozoa / Q000378:metabolism / Q000473:pathology*
D002843:Chromatin; D017382:Reactive Oxygen Species; D004247:DNA