title: Phosphonoxins: rational design and discovery of a potent nucleotide anti-Giardia agent.
abstract: Phosphonoxins, a new class of synthetic, rationally designed anti-microbial agents, are described. From this class a sub-micromolar inhibitor of Giardia trophozoite growth has been identified.
authors.affiliation: Center for Drug Design, Academic Health Center, University of Minnesota, Minneapolis, MN 55455, USA.
authors.forename: Dae-Hwan
authors.initials: DH
authors.lastname: Suk
authors.forename: Dominik
authors.initials: D
authors.lastname: Rejman
authors.forename: Christine C
authors.initials: CC
authors.lastname: Dykstra
authors.forename: Radek
authors.initials: R
authors.lastname: Pohl
authors.forename: Krzysztof W
authors.initials: KW
authors.lastname: Pankiewicz
authors.forename: Steven E
authors.initials: SE
authors.lastname: Patterson
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000737:chemistry / Q000494:pharmacology*; D015195:Drug Design; D005872:Giardia / Q000187:drug effects*; D006801:Humans; D015394:Molecular Structure; D009711:Nucleotides / Q000737:chemistry / Q000494:pharmacology*; D063065:Organophosphonates / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000981:Antiprotozoal Agents; D009711:Nucleotides; D063065:Organophosphonates