title: Persistent generalized anxiety after brief exposure to the dopamine antagonist metoclopramide.
abstract: The authors describe a 31-year-old woman who developed persistent generalized anxiety after brief exposure to the dopamine antagonist metoclopramide. Independently of that, she had experienced a panic attack followed by dystonias, shortly after a single dose of that drug, 17 years before. Both temporal association and recurrence of anxiety symptoms after re-challenge with metoclopramide suggest a causal relationship. The case might provide an initial piece of evidence that dopaminergic neurotransmission can be involved in the pathogenesis of generalized anxiety disorder.
authors.affiliation: Max Planck Institute of Psychiatry, Munich, Germany. kluge@mpipsykl.mpg.de
authors.forename: Michael
authors.initials: M
authors.lastname: Kluge
authors.forename: Petra
authors.initials: P
authors.lastname: Schüssler
authors.forename: Axel
authors.initials: A
authors.lastname: Steiger
mesh_terms: D000328:Adult; D000379:Agoraphobia / Q000139:chemically induced* / Q000523:psychology*; D000932:Antiemetics / Q000009:adverse effects* / Q000627:therapeutic use; D018492:Dopamine Antagonists / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D005767:Gastrointestinal Diseases / Q000150:complications / Q000188:drug therapy; D006801:Humans; D008787:Metoclopramide / Q000009:adverse effects* / Q000627:therapeutic use; D009325:Nausea / Q000188:drug therapy; D016584:Panic Disorder / Q000139:chemically induced / Q000523:psychology; D011569:Psychiatric Status Rating Scales
chemical_list: D000932:Antiemetics; D018492:Dopamine Antagonists; D008787:Metoclopramide