Eosinophilic pneumonia due to duloxetine.
A 32-year-old man presented with a 2-month history of worsening fever, chills, and cough despite therapy with oral antibiotics. Chest radiographs demonstrated migrating, peripheral upper lobe infiltrates. A CBC count demonstrated significant eosinophilia. At bronchoscopy, eosinophil-rich mucus was seen impacted throughout his bronchi. A transbronchial biopsy confirmed the diagnosis of eosinophilic pneumonia. Symptoms, eosinophilia, and radiographic abnormalities were reversed with cessation of duloxetine. This case report briefly reviews the diagnosis of drug-induced pulmonary infiltrates with eosinophilia (PIEs) and eosinophilic pneumonia. To our knowledge, this is the first reported case of PIEs due to duloxetine.
Espeleta
Vidal J
VJ
Division of Pulmonary/Critical Care Medicine,Stony Brook University, Stony Brook, NY.
Moore
William H
WH
Departments of Radiology, Stony Brook University, Stony Brook, NY.
Kane
Philip B
PB
Pathology, Stony Brook University, Stony Brook, NY.
Baram
Daniel
D
Division of Pulmonary/Critical Care Medicine,Stony Brook University, Stony Brook, NY.. Electronic address: daniel.baram@stonybrook.edu.
D000328:Adult; D000928:Antidepressive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001706:Biopsy; D001999:Bronchoscopy; D018549:Cryptogenic Organizing Pneumonia / Q000139:chemically induced / Q000175:diagnosis / Q000473:pathology; D003937:Diagnosis, Differential; D000068736:Duloxetine Hydrochloride; D006801:Humans; D008168:Lung / Q000187:drug effects / Q000473:pathology; D008297:Male; D011657:Pulmonary Eosinophilia / Q000139:chemically induced* / Q000175:diagnosis / Q000473:pathology; D013876:Thiophenes / Q000009:adverse effects* / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed
D000928:Antidepressive Agents; D013876:Thiophenes; D000068736:Duloxetine Hydrochloride