title: Antimicrobial prenylated anthracene derivatives from the leaves of Harungana madagascariensis.
abstract: Three new prenylated anthranoids, harunmadagascarins C (1) and D (2) and kenganthranol D (3), together with three known compounds (4-6) were isolated from the leaves of Harungana madagascariensis. Their structures were assigned by spectroscopic methods and by comparison with literature data. In the three new natural products 1-3, one or two prenyl groups are incorporated in furan, pyran, or cyclohexane rings in four different modes of annulation. Compounds 2, 4, and 6 were strongly active against the Gram-positive Bacillus megaterium.
authors.affiliation: Department of Chemistry, Higher Teachers' Training College, University of Yaounde 1, BP 47, Yaounde, Cameroon. fkouam@uycdc.uninet.cm
authors.forename: Simeon F
authors.initials: SF
authors.lastname: Kouam
authors.forename: Diane B
authors.initials: DB
authors.lastname: Yapna
authors.forename: Karsten
authors.initials: K
authors.lastname: Krohn
authors.forename: Bonaventure T
authors.initials: BT
authors.lastname: Ngadjui
authors.forename: Joseph
authors.initials: J
authors.lastname: Ngoupayo
authors.forename: Mohamed I
authors.initials: MI
authors.lastname: Choudhary
authors.forename: Barbara
authors.initials: B
authors.lastname: Schulz
mesh_terms: D000873:Anthracenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001410:Bacillus megaterium / Q000187:drug effects; D002163:Cameroon; D028084:Clusiaceae / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*
chemical_list: D000873:Anthracenes; D000900:Anti-Bacterial Agents; C519745:harunmadagascarin C; C519746:harunmadagascarin D; C519747:kenganthranol D