title: Highly Methylated 6-Hydroxyflavones and Other Flavonoids from Thymus piperella.
abstract: From the aerial parts of THYMUS PIPERELLA, the free flavone aglycones 5,6-dihydroxy-7,8,4'-trimethoxyflavone ( 1), 5,6-dihydroxy-7,8,3',4'-tetramethoxyflavone ( 2), 5,6-dihydroxy-7,3',4'-trimethoxyflavone ( 3), ladanein ( 4) (5,6-dihydroxy-7,4'-dimethoxy-flavone), 5-hydroxy-7,4'-dimethoxyflavone ( 5) and apigenin ( 6), the flavanones naringenin ( 7) and eriodictyol ( 8), and the flavone glycosides vicenin-2 ( 9), apigenin-7- O-beta- D-glucoside (10) and luteolin-7- O-beta- D-glucoside ( 11), have been isolated and identified. This is the first time that 5,6-dihydroxy-7,8,4'-trimethoxyflavone has been found as a natural product.
authors.affiliation: Laboratorio de Sustancias Orgánicas Naturales, C.E.B.A.S., C.S.I.C., Apdo. 195, Murcia 30003, Spain.
authors.forename: F A
authors.initials: FA
authors.lastname: Barberán
authors.forename: L
authors.initials: L
authors.lastname: Hernández
authors.forename: F
authors.initials: F
authors.lastname: Ferreres
authors.forename: F
authors.initials: F
authors.lastname: Tomás