[Complete response in an elderly patient with advanced gastric cancer treated with TS-1].
The patient was an 80-year-old man whose complaint was coffee-grounds vomit. He was diagnosed with advanced gastric cancer, T2N1H0P0M0, stage II. Though the curative operation was explained to the patient, he declined it because of complications of advanced age, diabetes and bronchial asthma; chemotherapy was chosen instead. TS-1 (80 mg/day) was administered for 28 days, followed by 14 days rest as one course. A partial response was observed after the first course, and no cancer cells were confirmed by endoscopic biopsy after the fifth course. Moreover, after the 14th course, CT showed a complete regression of lymph node metastasis, and no cancer cells were confirmed by endoscopic biopsy, for a complete response (CR). From now on, as society grays more and more, it is considered that elderly advanced gastric cancer patients with complications will increase. TS-1 single treatment is considered to be safe and outpatient treatment possible as one of the useful cures.
Harada
Katsuhisa
K
Dept. of Surgery II, Oita University of Medicine.
Noguchi
Tsuyoshi
T
Fujiwara
Shozo
S
Moriyama
Hatsuo
H
Kitano
Seigo
S
Kawahara
Katsunobu
K
D000230:Adenocarcinoma / Q000188:drug therapy*; D000369:Aged, 80 and over; D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use*; D048909:Diabetes Complications / Q000150:complications; D004334:Drug Administration Schedule; D004338:Drug Combinations; D006801:Humans; D006973:Hypertension / Q000150:complications; D008297:Male; D010094:Oxonic Acid / Q000627:therapeutic use*; D012074:Remission Induction; D013274:Stomach Neoplasms / Q000188:drug therapy*; D005641:Tegafur / Q000627:therapeutic use*
D000964:Antimetabolites, Antineoplastic; D004338:Drug Combinations; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid