title: Glutamate measurement in Parkinson's disease using MRS at 3 T field strength.
abstract: Loss of nigral dopamine neurons in Parkinson's disease induces abnormal activation of glutamate systems in the basal ganglia. The purpose of this study was to assess these changes in the lentiform nucleus using MRS with optimized glutamate sensitivity (TE-averaged method). Ten patients with Parkinson's disease and 10 healthy controls were examined. Compared with healthy controls, no significant differences in glutamate were measured in patients, but a trend to lower total creatine was observed.
authors.affiliation: INSERM, U594, Neuroimagerie fonctionnelle et métabolique, Grenoble, France. Nils.Kickler@ujf-grenoble.fr
authors.forename: Nils
authors.initials: N
authors.lastname: Kickler
authors.forename: Paul
authors.initials: P
authors.lastname: Krack
authors.forename: Valérie
authors.initials: V
authors.lastname: Fraix
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Lebas
authors.forename: Laurent
authors.initials: L
authors.lastname: Lamalle
authors.forename: Franck
authors.initials: F
authors.lastname: Durif
authors.forename: Alexandre
authors.initials: A
authors.lastname: Krainik
authors.forename: Chantal
authors.initials: C
authors.lastname: Rémy
authors.forename: Christoph
authors.initials: C
authors.lastname: Segebarth
authors.forename: Pierre
authors.initials: P
authors.lastname: Pollak
mesh_terms: D000978:Antiparkinson Agents / Q000627:therapeutic use; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000378:metabolism; D003342:Corpus Striatum / Q000378:metabolism*; D003401:Creatine / Q000378:metabolism; D018698:Glutamic Acid / Q000378:metabolism*; D005973:Glutamine / Q000378:metabolism; D006801:Humans; D007980:Levodopa / Q000627:therapeutic use; D009682:Magnetic Resonance Spectroscopy; D010300:Parkinson Disease / Q000175:diagnosis / Q000188:drug therapy / Q000378:metabolism*; D012016:Reference Values; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
chemical_list: D000978:Antiparkinson Agents; D005973:Glutamine; D001224:Aspartic Acid; D018698:Glutamic Acid; D007980:Levodopa; D005680:gamma-Aminobutyric Acid; C000179:N-acetylaspartate; D003401:Creatine