title: Inhibition of lens-aldose reductase activity by brazilin and haematoxylin.
abstract: Brazilin and haematoxylin, plant pigments, were examined for their effects on the Bovine-Lens aldose reductase (LAR)-activity. About 50% inhibition was observed in a concentration of 10 (-4) M-brazilin and 10 (-4) M-haematoxylin, and above 95% inhibition was observed in a concentration of 10 (-3) M-brazilin and 10 (-3)M-haematoxylin. In order to determine the type of inhibition, kinetic studies were also conducted with brazilin and haematoxylin, in which both were found to be noncompetitive inhibitors.
authors.affiliation: College of Pharmacy, Seoul National University, San 56-1, Sinlim-Dong, Kwanak-Gu, Seoul 151, Korea.
authors.forename: C K
authors.initials: CK
authors.lastname: Moon
authors.forename: Y P
authors.initials: YP
authors.lastname: Yun
authors.forename: J H
authors.initials: JH
authors.lastname: Lee
authors.forename: H
authors.initials: H
authors.lastname: Wagner
authors.forename: Y S
authors.initials: YS
authors.lastname: Shin