Association of common polymorphisms in inflammatory genes with risk of developing cancers of the upper aerodigestive tract.
OBJECTIVE
The purpose of this study was to investigate the role of polymorphisms of genes involved in inflammation in the risk of cancers of the upper aerodigestive tract (UADT).


METHODS
We have evaluated the role of polymorphisms in key genes related to inflammation, namely IL1B (rs1143627), COX2/PTGS2 (rs5275), and IL8 (rs4073) in a large case-control study comprising 811 UADT cancer cases and 1,083 controls.


RESULTS
An association was observed for squamous cell carcinoma of the pharynx for a polymorphism in the promoter of the IL1B gene, with an OR of 2.39 (95% CI = 1.19-4.81) for the homozygotes for the minor allele A promoter polymorphism of IL8 was associated with decreased risk of laryngeal cancer, with an OR of 0.70 (95% CI = 0.50-0.98) for carriers of the minor allele.


CONCLUSIONS
To our knowledge, this is the first report on the role of these polymorphisms with respect to UADT carcinogenesis. Our results suggest that inflammation-related polymorphisms play a role, albeit minor, in the risk of developing cancers of the upper aerodigestive tract.
Campa
Daniele
D
International Agency for Research on Cancer, 150 Cours Albert Thomas, 69372 Lyon, France.
Hashibe
Mia
M
Zaridze
David
D
Szeszenia-Dabrowska
Neonila
N
Mates
Ioan Nicolae
IN
Janout
Vladimir
V
Holcatova
Ivana
I
Fabiánová
Eleonóra
E
Gaborieau
Valérie
V
Hung
Rayjean J
RJ
Boffetta
Paolo
P
Brennan
Paul
P
Canzian
Federico
F
D016022:Case-Control Studies; D005061:Europe, Eastern / Q000453:epidemiology; D006801:Humans; D007249:Inflammation / Q000453:epidemiology / Q000235:genetics*; D053583:Interleukin-1beta / Q000235:genetics*; D007822:Laryngeal Neoplasms / Q000453:epidemiology / Q000235:genetics*; D009062:Mouth Neoplasms / Q000453:epidemiology / Q000235:genetics*; D010610:Pharyngeal Neoplasms / Q000453:epidemiology / Q000235:genetics*; D011110:Polymorphism, Genetic; D018570:Risk Assessment; D012307:Risk Factors
C508585:IL1B protein, human; D053583:Interleukin-1beta