Recent progress in discovery and development of antimitotic agents.
This review highlights structural diversity of antimitotic agents. In particular, we emphasized current antimitotic therapies based on modulation of microtubule dynamics. With several successful anticancer drugs on the market and numerous compounds in clinical developments, tubulin-binding agents remain among the most important categories of anticancer agents. Compounds targeting mitotic kinases and kinesins are also discussed.
Kiselyov
Alex
A
ChemDiv, Inc. 11558 Sorrento Valley Rd., Ste. 5, San Diego, CA 92121, USA. ask@chemdiv.com
Balakin
Konstantin V
KV
Tkachenko
Sergey E
SE
Savchuk
Nikolay
N
Ivachtchenko
Alexandre V
AV
D000818:Animals; D050256:Antimitotic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D006801:Humans; D016547:Kinesins / Q000037:antagonists & inhibitors; D008870:Microtubules / Q000187:drug effects; D008938:Mitosis / Q000187:drug effects* / Q000502:physiology*
D050256:Antimitotic Agents; D000970:Antineoplastic Agents; D016547:Kinesins