title: Late coronary artery lesions after neonatal arterial switch operation: results of surgical coronary revascularization.
abstract: OBJECTIVE
  To evaluate the results of surgical revascularization in children with coronary artery lesions following neonatal arterial switch operation (ASO).
  
  
  METHODS
  Among 755 neonates who underwent ASO, there were 713 late survivors (94%). Coronary lesions were detected in 34 patients (5%). Coronary revascularization was carried out in 19 children (mean age: 5.6+/-3.2 years) in whom myocardial ischemia was demonstrated by myocardial perfusion imaging studies. Coronary lesions involved the left main coronary artery in 14 cases, the left anterior descending artery in 3, and the right coronary artery in 2. Sixteen patients had coronary angioplasty (left main coronary artery in 11, left anterior descending artery in 3, right coronary artery in 2). Two patients underwent a mammary bypass and one had a saphenous vein proximal bypass.
  
  
  RESULTS
  There was no mortality or coronary event. Mean follow-up was 6.3+/-2.8 years. Patency of coronary repair was demonstrated in all patients; however, in one child with angioplasty of the left main coronary artery, there was a residual stenosis of the left anterior descending artery, and reoperation with a mammary bypass was required. Myocardial perfusion imaging was performed in 18 patients; myocardial perfusion was normal in 16 and 2 had minimal residual perfusion defects. Treadmill exercise testing was performed in 11 patients and was normal in all.
  
  
  CONCLUSIONS
  (1) Following ASO, coronary lesions are not uncommon and they are progressive. Routine and sequential coronary evaluation is necessary. (2) Coronary revascularization can be achieved using coronary angioplasty in most cases. Mammary bypass may be used in selected circumstances. Normal myocardial perfusion is restored in most patients.
authors.affiliation: Department of Pediatric Cardiac Surgery, University Paris Descartes and Sick Children Hospital, Paris, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Raisky
authors.forename: Eric
authors.initials: E
authors.lastname: Bergoend
authors.forename: Gabriella
authors.initials: G
authors.lastname: Agnoletti
authors.forename: Phalla
authors.initials: P
authors.lastname: Ou
authors.forename: Damien
authors.initials: D
authors.lastname: Bonnet
authors.forename: Daniel
authors.initials: D
authors.lastname: Sidi
authors.forename: Pascal R
authors.initials: PR
authors.lastname: Vouhé
mesh_terms: D006348:Cardiac Surgical Procedures / Q000379:methods; D002648:Child; D002675:Child, Preschool; D017023:Coronary Angiography / Q000379:methods; D003327:Coronary Disease / Q000209:etiology / Q000503:physiopathology / Q000601:surgery*; D023921:Coronary Stenosis / Q000209:etiology / Q000503:physiopathology / Q000601:surgery; D003331:Coronary Vessels / Q000503:physiopathology / Q000601:surgery; D004452:Echocardiography / Q000379:methods; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D015425:Myocardial Reperfusion / Q000379:methods; D009204:Myocardial Revascularization / Q000379:methods*; D011183:Postoperative Complications / Q000209:etiology / Q000601:surgery*; D013997:Time Factors; D014188:Transposition of Great Vessels / Q000150:complications / Q000503:physiopathology / Q000601:surgery*; D016896:Treatment Outcome; D014654:Vascular Patency / Q000502:physiology