[The clinical application of compound induced hypotension during functional endoscopic sinus surgery].
OBJECTIVE
To assess the clinic efficacy of compound induced hypotension during functional endoscopic sinus surgery.


METHODS
Sixty patients with chronic sinusitis and nasal polyps were divided into three groups: Sodium nitroprusside (SNP) group (A), diltiazem+SNP group (B), labetalol+SNP group (C). We started induced hypotension with beginning of functional endoscopic sinus surgery. Mean arterial pressure (MAP), heart rate (HR), cardiac output (CO), cardiac index (CI) and ejection fraction (EF) were recorded during induced hypotension. Sugar and lactic acid in arterial and venous blood were also assayed. Then we calculate rate-pressure product (RPP), arteriovenous difference in blood glucose [D(v-a) BG], blood glucose extraction rate (BGER), arteriovenous difference in lactate [L(v-a)] and lactate produce rate (LPR).


RESULTS
The dose of SNP applied in group B and C are fewer than group A ( P <0. 05). The cardiovascular functions and body metabolism of the patients in group B and C were stable and the anesthetic effect was satisfactory. Few adverse reaction of the drug was found in present study.


CONCLUSIONS
Induced hypotension with SNP compound of diltiazem or labetalol is an ideal way in clinical use and produce satisfied synergistic effect.
Wu
Tao
T
Department of Anesthesia, Xinhua Hospital of Jiaotong University Medical School, Shanghai, 200092, China.
Yang
Jun
J
Luo
Kai
K
Wang
Yingwei
Y
You
Xinmin
X
D000328:Adult; D000368:Aged; D000959:Antihypertensive Agents / Q000627:therapeutic use; D004110:Diltiazem / Q000627:therapeutic use; D004724:Endoscopy / Q000379:methods*; D005260:Female; D006801:Humans; D007023:Hypotension, Controlled / Q000379:methods*; D007741:Labetalol / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009298:Nasal Polyps / Q000601:surgery; D009599:Nitroprusside / Q000627:therapeutic use; D010256:Paranasal Sinuses / Q000601:surgery*; D012852:Sinusitis / Q000601:surgery
D000959:Antihypertensive Agents; D009599:Nitroprusside; D004110:Diltiazem; D007741:Labetalol