Analysis of substitution events in HIV-1 vif gene of the Korean clade.
Nucleotide and amino acid substitution pattern in vif gene of the Korean clade of HIV-1 isolated from Koreans were analyzed using consensus sequences. At nucleotide level, transition/transversion substitution ratio was 1.88, and nonsynonymous/synonymous substitution ratio was 2.67, suggesting a divergent evolution in the Korean clade. At amino acid level, there were 17 substitutions and G-->E substitution at position 37 may be responsible for change in predicted secondary structure.
Park
Chan Seung
CS
School of Life Sciences, Chungbuk National University, Cheongju, Republic of Korea.
Kim
Mi Sook
MS
Yi
Hyun Ah
HA
Lee
Dong Hun
DH
Lee
Keon Myung
KM
Lee
Chan Hee
CH
D000595:Amino Acid Sequence; D019943:Amino Acid Substitution; D044466:Asian People; D001483:Base Sequence; D016384:Consensus Sequence; D019143:Evolution, Molecular; D016346:Gene Products, vif / Q000737:chemistry / Q000235:genetics; D016341:Genes, vif; D015658:HIV Infections / Q000821:virology*; D015497:HIV-1 / Q000145:classification / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D017433:Protein Structure, Secondary; D016415:Sequence Alignment; D054320:vif Gene Products, Human Immunodeficiency Virus
D016346:Gene Products, vif; D054320:vif Gene Products, Human Immunodeficiency Virus