title: A landmark-based brain conformal parametrization with automatic landmark tracking technique.
abstract: In this paper, we present algorithms to automatically detect and match landmark curves on cortical surfaces to get an optimized brain conformal parametrization. First, we propose an automatic landmark curve tracing method based on the principal directions of the local Weingarten matrix. Our algorithm obtains a hypothesized landmark curves using the Chan-Vese segmentation method, which solves a Partial Differential Equation (PDE) on a manifold with global conformal parameterization. Based on the global conformal parametrization of a cortical surface, our method adjusts the landmark curves iteratively on the spherical or rectangular parameter domain of the cortical surface along its principal direction field, using umbilic points of the surface as anchors. The landmark curves can then be mapped back onto the cortical surface. Experimental results show that the landmark curves detected by our algorithm closely resemble these manually labeled curves. Next, we applied these automatically labeled landmark curves to generate an optimized conformal parametrization of the cortical surface, in the sense that homologous features across subjects are caused to lie at the same parameter locations in a conformal grid. Experimental results show that our method can effectively help in automatically matching cortical surfaces across subjects.
authors.affiliation: Department of Mathematics, UCLA, USA. malmlui@math.ucla.edu
authors.forename: Lok Ming
authors.initials: LM
authors.lastname: Lui
authors.forename: Yalin
authors.initials: Y
authors.lastname: Wang
authors.forename: Tony F
authors.initials: TF
authors.lastname: Chan
authors.forename: Paul M
authors.initials: PM
authors.lastname: Thompson
mesh_terms: D000465:Algorithms; D001185:Artificial Intelligence; D002540:Cerebral Cortex / Q000033:anatomy & histology*; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D010363:Pattern Recognition, Automated / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013382:Subtraction Technique