GBV-B as a pleiotropic virus: distribution of GBV-B in extrahepatic tissues in vivo.
GB virus B (GBV-B) infection of New World monkeys is considered to be a useful surrogate model for hepatitis C virus (HCV) infection. GBV-B replicates in the liver and induces acute resolving hepatitis but little is known whether the other organs could be permissive for the virus. We investigated the viral tropism of GBV-B in tamarins in the acute stage of viral infection and found that the viral genomic RNA could be detected in a variety of tissues. Notably, a GBV-B-infected tamarin with marked acute viremia scarcely showed a sign of hepatitis, due to preferential infection in lymphoid tissues such as lymph nodes and spleen. These results indicate that GBV-B as well as HCV is a pleiotropic virus in vivo.
Ishii
Koji
K
Department of Virology II, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8640, Japan.
Iijima
Sayuki
S
Kimura
Nobuyuki
N
Lee
Young-Jung
YJ
Ageyama
Naohide
N
Yagi
Shintaro
S
Yamaguchi
Kenjiro
K
Maki
Noboru
N
Mori
Ken-Ichi
K
Yoshizaki
Sayaka
S
Machida
Sanae
S
Suzuki
Tetsuro
T
Iwata
Naoko
N
Sata
Tetsutaro
T
Terao
Keiji
K
Miyamura
Tatsuo
T
Akari
Hirofumi
H
D000818:Animals; D004195:Disease Models, Animal; D018178:Flaviviridae Infections / Q000821:virology*; D029406:GB virus B / Q000235:genetics / Q000302:isolation & purification / Q000502:physiology*; D016174:Hepacivirus / Q000502:physiology; D006524:Hepatitis, Viral, Animal / Q000821:virology*; D008198:Lymph Nodes / Q000821:virology*; D012367:RNA, Viral / Q000032:analysis / Q000235:genetics; D012452:Saguinus; D013154:Spleen / Q000821:virology*; D018523:Tropism / Q000502:physiology
D012367:RNA, Viral