title: Treatment of hypercholesterolemia with ezetimibe in cardiac transplant recipients.
abstract: The purpose of this study was to examine the efficacy and tolerability of ezetimibe in cardiac transplant recipients who were intolerant of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) or unable to reach target lipid levels with statin therapy. After treatment with ezetimibe (n = 16), mean total and low-density lipoprotein cholesterol levels decreased significantly (228 +/- 40 mg/dl to 197 +/- 48 mg/dl, p = 0.003; and 149 +/- 34 mg/dl to 117 +/- 39 mg/dl, p < 0.001, respectively). One patient required a reduction in ezetimibe dose owing to myalgias; no other adverse events occurred. This initial experience indicates that ezetimibe is well tolerated in cardiac transplant recipients and is effective in reducing total and low-density lipoprotein cholesterol levels.
authors.affiliation: Heart Failure and Cardiac Transplant Center, Tufts-New England Medical Center, Boston, Massachusetts 02111, USA. apatel@tufts-nemc.org
authors.forename: Ayan R
authors.initials: AR
authors.lastname: Patel
authors.forename: Marietta S
authors.initials: MS
authors.lastname: Ambrose
authors.forename: Gretchen A
authors.initials: GA
authors.lastname: Duffy
authors.forename: Heather
authors.initials: H
authors.lastname: Cote
authors.forename: David
authors.initials: D
authors.lastname: DeNofrio
mesh_terms: D000328:Adult; D000368:Aged; D000924:Anticholesteremic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001384:Azetidines / Q000009:adverse effects / Q000627:therapeutic use*; D000069438:Ezetimibe; D005260:Female; D016027:Heart Transplantation; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood / Q000188:drug therapy*; D008074:Lipoproteins / Q000037:antagonists & inhibitors / Q000097:blood; D008077:Lipoproteins, LDL / Q000037:antagonists & inhibitors / Q000097:blood; D008297:Male; D008875:Middle Aged; D009135:Muscular Diseases / Q000139:chemically induced; D010146:Pain / Q000139:chemically induced
chemical_list: D000924:Anticholesteremic Agents; D001384:Azetidines; D008074:Lipoproteins; D008077:Lipoproteins, LDL; D000069438:Ezetimibe