Chronic neutrophilic leukaemia.
Chronic neutrophilic leukaemia is a rare myeloproliferative disease characterised by splenomegaly, sustained neutrophilia, raised vitamin B12 level and absence of the Philadelphia chromosome. We report a 74-year-old man who presented first with Sweet's syndrome and subsequently leukocytosis. He had splenomegaly, a raised vitamin B12 level, serum uric acid and neutrophil alkaline phosphatase score. Cytogenetic study of the marrow was normal and peripheral blood for BCR-ABL gene transcript was not detectable. He subsequently passed away with bronchopneumonia.
Gan
G G
GG
Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia. gingingan@yahoo.com
Pasagna
J F J
JF
Eow
G I
GI
Nadarajan
V S
VS
D000368:Aged; D020533:Angiogenesis Inhibitors / Q000627:therapeutic use; D017809:Fatal Outcome; D006801:Humans; D016898:Interferon-alpha / Q000627:therapeutic use; D015467:Leukemia, Neutrophilic, Chronic / Q000097:blood / Q000175:diagnosis* / Q000188:drug therapy; D008297:Male; D016133:Polymerase Chain Reaction
D020533:Angiogenesis Inhibitors; D016898:Interferon-alpha