title: GBV-B as a pleiotropic virus: distribution of GBV-B in extrahepatic tissues in vivo.
abstract: GB virus B (GBV-B) infection of New World monkeys is considered to be a useful surrogate model for hepatitis C virus (HCV) infection. GBV-B replicates in the liver and induces acute resolving hepatitis but little is known whether the other organs could be permissive for the virus. We investigated the viral tropism of GBV-B in tamarins in the acute stage of viral infection and found that the viral genomic RNA could be detected in a variety of tissues. Notably, a GBV-B-infected tamarin with marked acute viremia scarcely showed a sign of hepatitis, due to preferential infection in lymphoid tissues such as lymph nodes and spleen. These results indicate that GBV-B as well as HCV is a pleiotropic virus in vivo.
authors.affiliation: Department of Virology II, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8640, Japan.
authors.forename: Koji
authors.initials: K
authors.lastname: Ishii
authors.forename: Sayuki
authors.initials: S
authors.lastname: Iijima
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Kimura
authors.forename: Young-Jung
authors.initials: YJ
authors.lastname: Lee
authors.forename: Naohide
authors.initials: N
authors.lastname: Ageyama
authors.forename: Shintaro
authors.initials: S
authors.lastname: Yagi
authors.forename: Kenjiro
authors.initials: K
authors.lastname: Yamaguchi
authors.forename: Noboru
authors.initials: N
authors.lastname: Maki
authors.forename: Ken-Ichi
authors.initials: K
authors.lastname: Mori
authors.forename: Sayaka
authors.initials: S
authors.lastname: Yoshizaki
authors.forename: Sanae
authors.initials: S
authors.lastname: Machida
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Suzuki
authors.forename: Naoko
authors.initials: N
authors.lastname: Iwata
authors.forename: Tetsutaro
authors.initials: T
authors.lastname: Sata
authors.forename: Keiji
authors.initials: K
authors.lastname: Terao
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Miyamura
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Akari
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D018178:Flaviviridae Infections / Q000821:virology*; D029406:GB virus B / Q000235:genetics / Q000302:isolation & purification / Q000502:physiology*; D016174:Hepacivirus / Q000502:physiology; D006524:Hepatitis, Viral, Animal / Q000821:virology*; D008198:Lymph Nodes / Q000821:virology*; D012367:RNA, Viral / Q000032:analysis / Q000235:genetics; D012452:Saguinus; D013154:Spleen / Q000821:virology*; D018523:Tropism / Q000502:physiology
chemical_list: D012367:RNA, Viral