[Genetic markers of predisposition to an aggressive course of chronic C hepatitis].
The polymorphism of cytokine genes (11-1beta, IL-10, IL-6, and TGF-beta1) in patients with chronic C hepatitis and in healthy individuals was studied. The study found that the polymorphism of IL-1beta, IL-6, and TGF-beta1 may at least partially explain the genetic predisposition to an aggressive course of the disease with the development of terminal stage.
Abdullaev
S M
SM
Tselishcheva
Iu I
IuI
Samokhodskaia
L M
LM
Kvasovka
V V
VV
Ignatova
T M
TM
Krasnova
T N
TN
Bochkov
V N
VN
Mukhin
N A
NA
D000293:Adolescent; D000328:Adult; D004247:DNA / Q000235:genetics*; D018450:Disease Progression; D005260:Female; D020022:Genetic Predisposition to Disease; D019698:Hepatitis C, Chronic / Q000097:blood / Q000150:complications / Q000235:genetics*; D006801:Humans; D016753:Interleukin-10 / Q000097:blood / Q000235:genetics*; D053583:Interleukin-1beta / Q000097:blood / Q000235:genetics*; D015850:Interleukin-6 / Q000097:blood / Q000235:genetics*; D008103:Liver Cirrhosis / Q000209:etiology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D011379:Prognosis; D012720:Severity of Illness Index; D053773:Transforming Growth Factor beta1 / Q000097:blood / Q000235:genetics*
D053583:Interleukin-1beta; D015850:Interleukin-6; D053773:Transforming Growth Factor beta1; D016753:Interleukin-10; D004247:DNA