title: Temperature-compensated chemical reactions.
abstract: Circadian rhythms are daily oscillations in behaviors that persist in constant light/dark conditions with periods close to 24 h. A striking feature of these rhythms is that their periods remain fairly constant over a wide range of physiological temperatures, a feature called temperature compensation. Although circadian rhythms have been associated with periodic oscillations in mRNA and protein levels, the question of how to construct a network of chemical reactions that is temperature compensated remains unanswered. We discuss a general framework for building such a network.
authors.affiliation: Center for Neurobiology and Behavior, Columbia University College of Physicians and Surgeons, New York, New York 10032-2695, USA.
authors.forename: Kanaka
authors.initials: K
authors.lastname: Rajan
authors.forename: L F
authors.initials: LF
authors.lastname: Abbott
mesh_terms: D000222:Adaptation, Physiological / Q000502:physiology; D000818:Animals; D002940:Circadian Rhythm / Q000502:physiology*; D003198:Computer Simulation; D004330:Drosophila / Q000737:chemistry* / Q000378:metabolism*; D029721:Drosophila Proteins; D008954:Models, Biological; D008956:Models, Chemical; D009687:Nuclear Proteins / Q000737:chemistry* / Q000378:metabolism*; D056950:Period Circadian Proteins; D015398:Signal Transduction / Q000502:physiology*; D013696:Temperature
chemical_list: D029721:Drosophila Proteins; D009687:Nuclear Proteins; C539040:PER protein, Drosophila; D056950:Period Circadian Proteins