title: The trithorax-group protein Lid is a histone H3 trimethyl-Lys4 demethylase.
abstract: Recent studies have demonstrated that histone methylation can be dynamically regulated through active demethylation. However, no demethylase specific to histone H3 trimethyl-Lys4 (H3K4me3) has been identified. Here we report that the Drosophila melanogaster protein 'little imaginal discs' (Lid), a JmjC domain-containing trithorax group protein, can demethylate H3K4me3. Consistent with its genetic classification, Lid positively regulates Hox gene expression in S2 cells.
authors.affiliation: Howard Hughes Medical Institute, USA.
authors.forename: Nara
authors.initials: N
authors.lastname: Lee
authors.forename: Junyu
authors.initials: J
authors.lastname: Zhang
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Klose
authors.forename: Hediye
authors.initials: H
authors.lastname: Erdjument-Bromage
authors.forename: Paul
authors.initials: P
authors.lastname: Tempst
authors.forename: Richard S
authors.initials: RS
authors.lastname: Jones
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D000818:Animals; D004268:DNA-Binding Proteins / Q000378:metabolism*; D029721:Drosophila Proteins / Q000737:chemistry / Q000378:metabolism*; D004331:Drosophila melanogaster / Q000166:cytology / Q000201:enzymology*; D056466:Histone Demethylases; D011495:Histone-Lysine N-Methyltransferase / Q000737:chemistry / Q000378:metabolism*; D006657:Histones / Q000378:metabolism*; D007814:Larva / Q000166:cytology; D008239:Lysine / Q000378:metabolism*; D008745:Methylation; D050505:Mutant Proteins / Q000378:metabolism; D017434:Protein Structure, Tertiary; D021381:Protein Transport; D012319:RNA Polymerase II / Q000378:metabolism; D013379:Substrate Specificity; D014157:Transcription Factors / Q000378:metabolism*
chemical_list: D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; D006657:Histones; D050505:Mutant Proteins; D014157:Transcription Factors; C063460:Trl protein, Drosophila; D056466:Histone Demethylases; C518655:Lid protein, Drosophila; D011495:Histone-Lysine N-Methyltransferase; D012319:RNA Polymerase II; D008239:Lysine