Dynamic kinetic resolution of 2-oxo-3-aryl-succinates by organocatalyzed aldolization.
The dynamic kinetic resolution of 2-oxo-3-arylsuccinates was achieved vial-proline-catalyzed addition of acetone in acetonitrile at room temperature, providing the desired adduct in good yield with up to 87 : 13 dr and high ee up to 99%.
Wang
Yajun
Y
Key Laboratory of Organic Synthesis of Province Jiangsu, College of Chemistry and Chemical Engineering, Suzhou University, Suzhou, China.
Shen
Zongxuan
Z
Li
Bin
B
Zhang
Yong
Y
Zhang
Yawen
Y