Further evidence for BRCA1 communication with the inactive X chromosome.
BRCA1, a breast and ovarian cancer-suppressor gene, exerts tumor-suppressing functions that appear to be associated, at least in part, with its DNA repair, checkpoint, and mitotic regulatory activities. Earlier work from our laboratory also suggested an ability of BRCA1 to communicate with the inactive X chromosome (Xi) in female somatic cells (Ganesan et al., 2002). Xiao et al. (2007) (this issue of Cell) have challenged this conclusion. Here we discuss recently published data from our laboratory and others and present new results that, together, provide further support for a role of BRCA1 in the regulation of XIST concentration on Xi in somatic cells.
Silver
Daniel P
DP
Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.
Dimitrov
Stoil D
SD
Feunteun
Jean
J
Gelman
Rebecca
R
Drapkin
Ronny
R
Lu
Shihua D
SD
Shestakova
Elena
E
Velmurugan
Soundarapandian
S
Denunzio
Nicholas
N
Dragomir
Serban
S
Mar
Jessica
J
Liu
Xiaoling
X
Rottenberg
Sven
S
Jonkers
Jos
J
Ganesan
Shridar
S
Livingston
David M
DM
D000818:Animals; D019313:BRCA1 Protein / Q000235:genetics / Q000378:metabolism*; D045744:Cell Line, Tumor; D004622:Embryo, Mammalian / Q000166:cytology; D005260:Female; D005347:Fibroblasts; D019398:Genes, BRCA1; D024522:Genes, BRCA2; D008325:Mammary Neoplasms, Experimental / Q000235:genetics / Q000378:metabolism; D051379:Mice; D009154:Mutation; D034622:RNA Interference; D062085:RNA, Long Noncoding; D022661:RNA, Untranslated / Q000378:metabolism*; D014960:X Chromosome / Q000378:metabolism*; D049951:X Chromosome Inactivation
D019313:BRCA1 Protein; D062085:RNA, Long Noncoding; D022661:RNA, Untranslated; C077885:XIST non-coding RNA