title: Neuropsychologic assessment of patients with advanced Parkinson disease submitted to extradural motor cortex stimulation.
abstract: OBJECTIVE
  The aim of this study was to evaluate changes in cognitive functioning and emotive state in 3 inpatients with advanced Parkinson disease (PD) treated with extradural motor cortex stimulation (EMCS), an experimental neurosurgical procedure.
  
  
  BACKGROUND
  Studies on the neuropsychologic assessment of patients with PD after EMCS are in process. The procedure has been applied for some years as an experimental method for treating PD.
  
  
  METHODS
  A battery of neuropsychologic tests and emotive assessment scales were administered to 3 inpatients with PD 2 days before the intervention and then again after 1 year to evaluate changes in cognitive functioning and emotive state.
  
  
  RESULTS
  At 1-year postintervention, cognitive functions and depressive symptoms were steady; 2 patients showed a mild improvement in quality of life.
  
  
  CONCLUSIONS
  In this patient group, EMCS, an experimental neurosurgical treatment, had a positive effect on motor symptoms. Neuropsychologic assessment after a 1-year follow-up period showed that cognitive functions had not changed with respect to baseline characteristics.
authors.affiliation: Neuroscience Department, Clinical Psychology Service, Neurosurgical Clinic, University of Turin, Turin, Italy. donato.munno@unito.it
authors.forename: Donato
authors.initials: D
authors.lastname: Munno
authors.forename: Silvia
authors.initials: S
authors.lastname: Caporale
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Zullo
authors.forename: Sara
authors.initials: S
authors.lastname: Sterpone
authors.forename: Alessandro
authors.initials: A
authors.lastname: Malfatto
authors.forename: Sergio
authors.initials: S
authors.lastname: Zeme
authors.forename: Carlo A
authors.initials: CA
authors.lastname: Pagni
mesh_terms: D000342:Affective Symptoms / Q000209:etiology / Q000628:therapy; D000368:Aged; D000369:Aged, 80 and over; D003072:Cognition Disorders / Q000150:complications / Q000628:therapy; D004599:Electric Stimulation Therapy / Q000379:methods*; D004644:Emotions; D006801:Humans; D008297:Male; D008875:Middle Aged; D019060:Minimally Invasive Surgical Procedures / Q000379:methods; D009044:Motor Cortex / Q000503:physiopathology*; D009048:Motor Skills; D009483:Neuropsychological Tests; D019635:Neurosurgical Procedures / Q000379:methods; D010300:Parkinson Disease / Q000150:complications / Q000503:physiopathology / Q000523:psychology / Q000628:therapy*; D020127:Recovery of Function; D012720:Severity of Illness Index; D016896:Treatment Outcome