Anti-TB activity of Evodia elleryana bark extract.
An ethyl acetate extract of bark from Evodia elleryana produced significant growth inhibition of Mycobacterium tuberculosis at concentrations only minimally inhibitory to human T cells. The crude extract yielded 95% inhibition of TB at 50 microg/ml. The crude extract yielded 29% growth inhibition of human T-cells in culture at that concentration.
Barrows
Louis R
LR
Department of Pharmacology and Toxicology, University of Utah, College of Pharmacy, Salt Lake City, UT, USA. lbarrows@pharm.utah.edu
Powan
Emma
E
Pond
Christopher D
CD
Matainaho
Teatulohi
T
D000995:Antitubercular Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D032086:Evodia; D006801:Humans; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D008517:Phytotherapy; D024301:Plant Bark; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D013601:T-Lymphocytes / Q000187:drug effects
D000995:Antitubercular Agents; D010936:Plant Extracts