A polymorphism of the interleukin-1 beta gene is associated with sperm pathology in humans.
In a prospective case-control study of 127 normozoospermic and 435 non-normozoospermic Caucasian men, the genotype frequencies of a polymorphism of the interleukin-1 beta gene (IL-1beta Taq C-->T) were statistically significantly different between groups (homozygous wild-type C/C [57%], heterozygous C/T [42%], and homozygous mutant T/T [1%] vs. C/C [57%], C/T [36%], T/T [7%] for normozoospermic and non-normozoospermic men, respectively; odds ratio, 4.8; 95% confidence interval, 1.13 to 20.28). This association was restricted to men with the oligoasthenoteratozoospermia (OAT) syndrome. We conclude that the investigated polymorphism is associated with sperm pathology in Caucasians.
Bentz
Eva-Katrin
EK
Departments of Gynecologic Endocrinology and Reproductive Medicine, University of Vienna School of Medicine, Vienna, Austria. eva-katrin.bentz@meduniwien.ac.at <eva-katrin.bentz@meduniwien.ac.at>
Hefler
Lukas A
LA
Denschlag
Dominik
D
Pietrowski
Detlef
D
Buerkle
Bernd
B
Tempfer
Clemens B
CB
D053713:Azoospermia / Q000235:genetics / Q000473:pathology; D006801:Humans; D053583:Interleukin-1beta / Q000235:genetics*; D008297:Male; D011110:Polymorphism, Genetic; D012016:Reference Values; D013094:Spermatozoa / Q000473:pathology*
D053583:Interleukin-1beta