Lipolysis of emulsion models of triglyceride-rich lipoproteins is altered in male patients with abdominal aorta aneurysm.
Disorders of the lipid metabolism may play a role in the genesis of abdominal aorta aneurysm. The present study examined the intravascular catabolism of chylomicrons, the lipoproteins that carry the dietary lipids absorbed by the intestine in the circulation in patients with abdominal aorta aneurysm. Thirteen male patients (72 +/- 5 years) with abdominal aorta aneurysm with normal plasma lipid profile and 13 healthy male control subjects (73 +/- 5 years) participated in the study. The method of chylomicron-like emulsions was used to evaluate this metabolism. The emulsion labeled with 14C-cholesteryl oleate and (3)H-triolein was injected intravenously in both groups. Blood samples were taken at regular intervals over 60 min to determine the decay curves. The fractional clearance rate (FCR) of the radioactive labels was calculated by compartmental analysis. The FCR of the emulsion with (3)H-triolein was smaller in the aortic aneurysm patients than in controls (0.025 +/- 0.017 vs 0.039 +/- 0.019 min-1; P < 0.05), but the FCR of 14C-cholesteryl oleate of both groups did not differ. In conclusion, as indicated by the triglyceride FCR, chylomicron lipolysis is diminished in male patients with aortic aneurysm, whereas the remnant removal which is traced by the cholesteryl oleate FCR is not altered. The results suggest that defects in the chylomicron metabolism may represent a risk factor for development of abdominal aortic aneurysm.
Hosni
J J
JJ
Laboratório de Metabolismo de Lípides, Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, Av. Dr. Enéas C. Aguiar 44, 05403-000 São Paulo, SP, Brazil.
Vinagre
C G
CG
Mady
C
C
Maranhão
R C
RC
D000368:Aged; D017544:Aortic Aneurysm, Abdominal / Q000097:blood / Q000209:etiology / Q000378:metabolism*; D015992:Body Mass Index; D002250:Carbon Radioisotopes; D016022:Case-Control Studies; D002788:Cholesterol Esters / Q000008:administration & dosage / Q000493:pharmacokinetics*; D002914:Chylomicrons / Q000008:administration & dosage / Q000493:pharmacokinetics*; D004655:Emulsions; D006801:Humans; D007275:Injections, Intravenous; D008066:Lipolysis; D008297:Male; D008657:Metabolic Clearance Rate; D014304:Triolein / Q000008:administration & dosage / Q000493:pharmacokinetics*
D002250:Carbon Radioisotopes; D002788:Cholesterol Esters; D002914:Chylomicrons; D004655:Emulsions; D014304:Triolein; C014409:cholesteryl oleate