Pellagra: A clue as to why energy failure causes diseases?
Pellagra is a curable dietary illness that unchecked leads to dementia, diarrhoea, dermatitis and death due to lack of the precursors for NAD(H). In addition it caused a wide range of monosyndromic degenerative and functional neurological disorders as well as profound developmental, premature aging and metabolic syndromes. Pellagrins harbour many chronic infections including tuberculosis, yeasts and malaria, that may be symbionts supplying nicotinamide adenine dinucleotide {NAD(H)} when the diet is poor. Many common diseases and aging may be caused by electrogenic energy mismatches from lack of a timely supply of NAD(H) creating disturbed metabolic fields and "protonopathies". Initially these may present in compartments fronted by homeostatic corrections from chronic symbiotic infections to inflammatory disease, cancer and degenerative/autophagic diseases that can all release NAD(H).
Williams
Adrian C
AC
Divisions of Neurosciences, University of Birmingham, Birmingham B15 2TT, UK. Adrian.Williams@uhb.nhs.uk
Ramsden
David B
DB
D000818:Animals; D001671:Biochemistry / Q000379:methods; D004032:Diet; D006801:Humans; D007239:Infections; D007249:Inflammation; D008660:Metabolism; D008954:Models, Biological; D008962:Models, Theoretical; D009243:NAD / Q000378:metabolism; D009536:Niacinamide / Q000494:pharmacology; D009752:Nutritional Status; D010383:Pellagra / Q000175:diagnosis* / Q000473:pathology
D009243:NAD; D009536:Niacinamide