Borreliacidal OspC antibody response of canines with Lyme disease differs significantly from that of humans with Lyme disease.
Humans reliably produce high concentrations of borreliacidal OspC antibodies specific for the seven C-terminal amino acids shortly after infection with Borrelia burgdorferi. We show that dogs also produce OspC borreliacidal antibodies but that their frequencies, intensities, and antigenicities differ significantly. The findings therefore confirm a major difference between the borreliacidal antibody responses of humans and canines with Lyme disease.
Lovrich
Steven D
SD
Microbiology Research Laboratory, Gundersen Lutheran Medical Center, 1300 Badger Street, La Crosse, Wisconsin 54601, USA.
La Fleur
Rhonda L
RL
Jobe
Dean A
DA
Johnson
Jennifer C
JC
Asp
Krista E
KE
Schell
Ronald F
RF
Callister
Steven M
SM
D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood*; D000942:Antigens, Bacterial / Q000097:blood / Q000276:immunology*; D001425:Bacterial Outer Membrane Proteins / Q000097:blood / Q000276:immunology*; D001426:Bacterial Proteins / Q000097:blood / Q000276:immunology*; D026481:Blotting, Far-Western; D025065:Borrelia burgdorferi / Q000276:immunology*; D004285:Dogs; D006801:Humans; D008074:Lipoproteins / Q000097:blood / Q000276:immunology*; D008193:Lyme Disease / Q000097:blood / Q000276:immunology*
D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D001425:Bacterial Outer Membrane Proteins; D001426:Bacterial Proteins; D008074:Lipoproteins; C079616:OspC protein; C084998:OspE protein, Borrelia burgdorferi