Palliative intravenous cisplatin treatment for concurrent peritoneal and pleural mesothelioma in a dog.
A 10-year-old Maltese dog was presented with abdominal distention and dyspnea. Cytological examination of pleural and peritoneal effusion was suggestive of malignant effusion of glandular origin. Numerous, multifocal, tan to white nodules were disseminated throughout the surface of the abdominal organs and peritoneum at biopsy. Histologically, the tumors were revealed to be an epithelial type of mesothelioma. Neoplastic cells co-expressed cytokeratin and vimentin. Intravenous administration of cisplatin was chosen as the treatment. During treatment, the dog's overall body condition improved and the clinical signs were relieved without significant side effects. The survival time from diagnosis to sudden death by unknown cause was 153 days.
Seo
Kyoung-Won
KW
Department of Veterinary Internal Medicine, College of Veterinary Medicine, Seoul National University, Korea.
Choi
Ul-Soo
US
Jung
Yun-Chan
YC
Hong
Su-Ji
SJ
Byeun
Ye-Eun
YE
Kang
Min-Soo
MS
Pachrin
B
B
Kim
Wan-Hee
WH
Hwang
Cheol-Yong
CY
Kim
Dae-Yong
DY
Youn
Hwa-Young
HY
Lee
Chang-Woo
CW
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002945:Cisplatin / Q000627:therapeutic use*; D004283:Dog Diseases / Q000188:drug therapy* / Q000473:pathology; D004285:Dogs; D017809:Fatal Outcome; D005260:Female; D006651:Histocytochemistry / Q000662:veterinary; D008654:Mesothelioma / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D010534:Peritoneal Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D010997:Pleural Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*
D000970:Antineoplastic Agents; D002945:Cisplatin