title: Loss of Aire-dependent thymic expression of a peripheral tissue antigen renders it a target of autoimmunity.
abstract: Both humans and mice with a mutation in the autoimmune regulator (aire) gene develop multiorgan autoimmune disease. Aire was shown to exert its critical function in medullary epithelial cells of the thymus by promoting ectopic expression of peripheral tissue antigens. It was hypothesized that the widespread autoimmunity of Aire-deficient individuals reflects a lack of tolerance induction to the repertoire of peripheral tissue antigens expressed in the thymus of normal individuals. Here, we substantiate this hypothesis by identifying Mucin 6 as a stomach-specific antigen targeted by autoantibodies in gastritis-prone mice lacking thymic expression of aire and demonstrate that transcription of the Mucin 6 gene in thymic medullary epithelial cells is indeed Aire-dependent.
authors.affiliation: Section on Immunology and Immunogenetics, Joslin Diabetes Center, Department of Medicine, Brigham and Women's Hospital, 44 Binney Street, Boston, MA 02215, USA.
authors.forename: Irina
authors.initials: I
authors.lastname: Gavanescu
authors.forename: Benedikt
authors.initials: B
authors.lastname: Kessler
authors.forename: Hidde
authors.initials: H
authors.lastname: Ploegh
authors.forename: Christophe
authors.initials: C
authors.lastname: Benoist
authors.forename: Diane
authors.initials: D
authors.lastname: Mathis
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001327:Autoimmune Diseases / Q000378:metabolism; D015551:Autoimmunity; D001854:Bone Marrow Cells / Q000166:cytology; D004847:Epithelial Cells / Q000166:cytology*; D005786:Gene Expression Regulation; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D008969:Molecular Sequence Data; D055272:Mucin-6; D009077:Mucins / Q000096:biosynthesis; D009154:Mutation; D013950:Thymus Gland / Q000276:immunology / Q000378:metabolism*; D014157:Transcription Factors / Q000235:genetics* / Q000378:metabolism; D000096927:AIRE Protein
chemical_list: D055272:Mucin-6; D009077:Mucins; D014157:Transcription Factors; D000096927:AIRE Protein; C524734:MUC6 protein, human; C524735:Muc6 protein, mouse