[Terpenoid compounds isolated from Ligularia sagitta].
OBJECTIVE
To study the chemical constituents of radix and rhizome of Ligularia sagitta.


METHODS
Isolation and purification were carried out on the column chromatography of silica gel and sephadex LH -20. The structures were identified by spectral analysis.


RESULTS
Seven terpenoid compounds were isolated from the radix and rhizome of L. sagitta. Five of them are sesquiterpenoids, the structures were determined as 7alpha-hydroxy-9(10) -ene-1, 8-dioxo-6, 7-dihydrofuranoeremophilane (1), 1p, 10P3-epoxy-6beta, 8 beta-dihydroxy-eremophil7 (11) -en-12, 8alpha-olide (2) , 1-oxo-9-desoxycacalol (3), benzofuranoeremophil-l-ene (4) and bakkenolide (5); other two compounds belong to triterpenoid. 3p, 16P3-dihydroxy-12-oleanen-28-al (6) and lupeol (7).


CONCLUSIONS
Compoundsl-3 and 6 were: isolated from L. sagitta for the first time, and compounds 3 and 6 were obtained from Ligularia for the first time.
Liu
Shou-jin
SJ
Department of Pharmacognosy, China Phamraceutical University, Nanjing 210038, China.
Zhang
Mian
M
Wang
Zheng-tao
ZT
Liu
Jian-qun
JQ
Zhang
Chao-feng
CF
D015107:4-Butyrolactone / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification; D019659:Asteraceae / Q000737:chemistry*; D009828:Oleanolic Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D027343:Rhizome / Q000737:chemistry; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification*; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification*
C528301:1-oxo-9-desoxycacalol; C528302:3beta,16beta-dihydroxy-12-oleanen-28-al; D012717:Sesquiterpenes; D013729:Terpenes; D009828:Oleanolic Acid; D015107:4-Butyrolactone; C016257:bakkenolide A