Polymorphism of selected enzymes involved in detoxification and biotransformation in relation to lung cancer.
Available data indicate that there are significant differences in individual susceptibility to lung cancer within the human population. It is believed to be underlie by inherited genetic predispositions related to the genetic polymorphism of several enzymes involved in the detoxification and xenobiotic metabolism. In this review, we collect and discuss the evidence reported up to date on the association between lung cancer and genetic polymorphism of cytochromes P450, N-acetyltransferase, glutathione S-transferases, microsomal epoxide hydrolase, NAD(P)H:quinone oxidoreductase, myeloperoxidase and glutathione peroxidase. All these genes might appear to be candidates for lung cancer susceptibility genes, nevertheless, the present state of the art still offers only a limited explanation of the link between such polymorphisms and increased risk of lung cancer.
Gresner
Peter
P
Department of Toxicology and Carcinogenesis, Nofer Institute of Occupational Medicine, Lodz, Poland. pgresner@yahoo.com
Gromadzinska
Jolanta
J
Wasowicz
Wojciech
W
D000123:Acetyltransferases / Q000235:genetics*; D000483:Alleles; D001711:Biotransformation; D016022:Case-Control Studies; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics*; D004851:Epoxide Hydrolases / Q000235:genetics*; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005979:Glutathione Peroxidase / Q000235:genetics*; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D008658:Inactivation, Metabolic; D008175:Lung Neoplasms / Q000201:enzymology / Q000235:genetics*; D017720:Molecular Epidemiology; D016660:NAD(P)H Dehydrogenase (Quinone) / Q000235:genetics*; D009195:Peroxidase / Q000235:genetics*; D011110:Polymorphism, Genetic; D015262:Xenobiotics / Q000378:metabolism
D015262:Xenobiotics; D003577:Cytochrome P-450 Enzyme System; D009195:Peroxidase; D005979:Glutathione Peroxidase; D016660:NAD(P)H Dehydrogenase (Quinone); D000123:Acetyltransferases; D005982:Glutathione Transferase; D004851:Epoxide Hydrolases