Rising ELISPOT count prior to the onset of symptoms of full-blown tuberculosis disease.
The relationship between the T-cell response to mycobacterial antigens and the likelihood of progression to disease has not been defined. We report a rapidly rising ELISPOT count in a 55-year-old man with evidence of Mycobacterium tuberculosis infection prior to the onset of symptoms of disease. This case illustrates the possible utility of quantitative changes in the ELISPOT count in predicting progression from M. tuberculosis infection to disease.
Adetifa
I M O
IM
Bacterial Diseases Programme, Medical Research Council Laboratories, Banjul, The Gambia. iadetifa@mrc.gm
Brookes
R
R
Lugos
M D
MD
de Jong
B C
BC
Antonio
M
M
Adegbola
R A
RA
Hill
P C
PC
D000995:Antitubercular Agents / Q000627:therapeutic use; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D014374:Tuberculin Test; D014397:Tuberculosis, Pulmonary / Q000175:diagnosis* / Q000188:drug therapy / Q000635:transmission
D000995:Antitubercular Agents