title: Comparison between fetal heart rate standard parameters and complexity indexes for the identification of severe intrauterine growth restriction.
abstract: OBJECTIVE
  The intrauterine growth restriction (IUGR) is a pathological state: the fetus is at risk of hypoxia and this condition is associated with increased perinatal morbidity and mortality. However, evidence-based guidelines for clinical surveillance are poor and lack reliable indexes. This study introduces new procedures to extract parameters from the fetal heart rate signal in order to identify severe intrauterine growth restricted (IUGR) fetuses
  
  
  METHODS
  Standard parameters (time domain and frequency domain indexes) are compared to a new parameter, the Lempel Ziv complexity, and to two regularity estimators (approximate entropy and sample entropy). The paper analyzes the robustness of the indexes coming from the parameter extraction procedure.
  
  
  CONCLUSIONS
  The results show that the LZ complexity is a stable parameter and it is able to significantly discriminate the severe IUGR (preterm delivered) from moderate IUGR (at term delivered) and from healthy fetuses.
authors.affiliation: Dipartimento di Bioingegneria, Politecnico di Milano, Milano, Italy. manuela.ferrario@biomed.polimi.it
authors.forename: M
authors.initials: M
authors.lastname: Ferrario
authors.forename: M G
authors.initials: MG
authors.lastname: Signorini
authors.forename: G
authors.initials: G
authors.lastname: Magenes
mesh_terms: D000465:Algorithms; D015415:Biomarkers; D005317:Fetal Growth Retardation / Q000503:physiopathology*; D005865:Gestational Age; D006340:Heart Rate, Fetal / Q000502:physiology*; D006801:Humans; D007257:Information Theory; D016571:Neural Networks, Computer; D012815:Signal Processing, Computer-Assisted; D013995:Time
chemical_list: D015415:Biomarkers