title: Neuraminidase inhibitors improve outcome of patients with leukemia and influenza: an observational study.
abstract: We reviewed the records of 33 patients with leukemia who experienced influenza during the period from October 2000 to March 2004. Three (38%) of the 8 patients who did not receive neuraminidase inhibitor therapy and none of the 25 patients who received it died of influenza pneumonia (P=.001). The use of neuraminidase inhibitor therapy seems to improve the outcome of influenza in patients with leukemia.
authors.affiliation: Department of Infectious Diseases, Infection Control, and Employee Health, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77230-1402, USA. rfchemaly@mdanderson.org
authors.forename: Roy F
authors.initials: RF
authors.lastname: Chemaly
authors.forename: Harrys A
authors.initials: HA
authors.lastname: Torres
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Aguilera
authors.forename: Gloria
authors.initials: G
authors.lastname: Mattiuzzi
authors.forename: Maria
authors.initials: M
authors.lastname: Cabanillas
authors.forename: Hagop
authors.initials: H
authors.lastname: Kantarjian
authors.forename: Virginia
authors.initials: V
authors.lastname: Gonzalez
authors.forename: Amar
authors.initials: A
authors.lastname: Safdar
authors.forename: Issam I
authors.initials: II
authors.lastname: Raad
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000998:Antiviral Agents / Q000627:therapeutic use*; D015331:Cohort Studies; D015897:Comorbidity; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007251:Influenza, Human / Q000175:diagnosis / Q000188:drug therapy* / Q000453:epidemiology*; D007951:Leukemia, Myeloid / Q000175:diagnosis / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D009439:Neuraminidase / Q000037:antagonists & inhibitors* / Q000627:therapeutic use; D011336:Probability; D012189:Retrospective Studies; D018570:Risk Assessment; D015996:Survival Rate; D016896:Treatment Outcome
chemical_list: D000998:Antiviral Agents; D009439:Neuraminidase