[Hemolytic uremic syndrome (HUS). An up-dated nosological classification].
An up-date of the causes and pathogenesis of the HUS is reported. After more than 40 years of research we are able to define the infectious agents and the toxin involved. The mechanisms and the molecules involved in the non-diarrheal (atypical) entities producing HUS have also been characterized. This new situation allows us to develop a diagnostic algorithm that enables us to better define preventive and therapeutic measures, based on more rational evidence.
Repetto
Horacio A
HA
Hospital Nacional Prof. A. Posadas. Dep. Pediatria, Facultad de Medicina, Universidad de Buenos Aires. harepetto@yahoo.com.ar
D051722:ADAM Proteins / Q000172:deficiency; D000071120:ADAMTS13 Protein; D000465:Algorithms; D003167:Complement Activation / Q000502:physiology; D017242:Complement Factor H / Q000172:deficiency; D005921:Glomerulonephritis / Q000150:complications; D006084:Graft Rejection / Q000150:complications; D053878:Hemolytic Agents / Q000009:adverse effects; D006463:Hemolytic-Uremic Syndrome / Q000175:diagnosis / Q000209:etiology* / Q000378:metabolism; D006801:Humans; D051916:Membrane Cofactor Protein / Q000172:deficiency; D011697:Purpura, Thrombotic Thrombocytopenic / Q000150:complications; D022621:Shiga Toxin / Q000378:metabolism; D014841:von Willebrand Factor / Q000378:metabolism
D053878:Hemolytic Agents; D051916:Membrane Cofactor Protein; D014841:von Willebrand Factor; D022621:Shiga Toxin; D017242:Complement Factor H; D051722:ADAM Proteins; D000071120:ADAMTS13 Protein; C099604:ADAMTS13 protein, human