[Biogenic amines regulate the reproductive function in Drosophila as neurohormones].
We studied the influence of experimental increase in the octopamine and dopamine content on the level of juvenile hormone degradation, oogenesis, and fertility in wild type D. virilis flies. Feeding of flies on octopamine led to a significantly decreased level of juvenile hormone degradation (increased titer) in young and sexually mature females, rather than in males, markedly decreased the number of vitellogenic (stages 8-10) and mature (stage 14) oocytes), and sharply reduced fertility. Feeding of flies on dopamine decreased the juvenile hormone degradation (increased titer) in young wild type females and increased it (lowered the juvenile hormone titer) in sexually mature females, as well as decreased the fertility of wild type females to a level characteristic for D. virilis line with a mutation doubling the endogenous dopamine level. A possible mechanism of the influence of these amines on the reproductive function in Drosophila as neurohormones is discussed and a conclusion is drawn that the reduced fertility of females at an increased level of amines appears to be related to an increased level of ecdysteroids, which is caused by an increased, as a result of decreased degradation, juvenile hormone titer.
Rauschenbakh
I Iu
IIu
Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, pr. Akademika Lavrent'eva 10, Novosibirsk, 630090 Russia. iraushen@bionet.nsc.ru
Karpova
E K
EK
Gruntenko
N E
NE
Saprykina
Z V
ZV
Shumnaia
L V
LV
Faddeeva
N V
NV
D000818:Animals; D001679:Biogenic Amines / Q000494:pharmacology / Q000502:physiology; D004298:Dopamine / Q000494:pharmacology / Q000502:physiology*; D004330:Drosophila / Q000187:drug effects / Q000502:physiology*; D005260:Female; D005298:Fertility / Q000187:drug effects; D007605:Juvenile Hormones / Q000378:metabolism*; D008297:Male; D018377:Neurotransmitter Agents / Q000494:pharmacology / Q000502:physiology*; D009655:Octopamine / Q000494:pharmacology / Q000502:physiology*; D009866:Oogenesis / Q000187:drug effects
D001679:Biogenic Amines; D007605:Juvenile Hormones; D018377:Neurotransmitter Agents; D009655:Octopamine; D004298:Dopamine