title: Assessment of intakes and doses to workers followed for 15 years after accidental inhalation of 60CO.
abstract: Intakes and doses are assessed for seven workers who accidentally inhaled particles containing Co in the same incident. Comprehensive whole body data to 15 y, and some early urine and fecal data, are available for each individual. The biokinetic and dosimetric models currently recommended by ICRP have been used to assess these cases. It was not possible to obtain good fits to the data using the ICRP models with their default parameter values. However, good fits to all the measurement data were obtained by varying parameter values following a procedure similar to that recommended in recently developed guidelines for assessment of internal doses from monitoring data. It was found that retention in the lungs was much longer than predicted by the ICRP Human Respiratory Tract Model, and so for each case it was necessary to reduce the particle transport clearance of material from the deep lungs. This reduction in lung clearance rates, and the use of specific AMAD values, were the dominating factors in changing assessed doses from those calculated using ICRP default values.
authors.affiliation: Radiation Protection Division, Health Protection Agency (HPA), Chilton, Didcot, Oxon OX11 0RQ, UK.
authors.forename: K
authors.initials: K
authors.lastname: Davis
authors.forename: J W
authors.initials: JW
authors.lastname: Marsh
authors.forename: M
authors.initials: M
authors.lastname: Gerondal
authors.forename: M R
authors.initials: MR
authors.lastname: Bailey
authors.forename: B
authors.initials: B
authors.lastname: Le Guen
mesh_terms: D000062:Accidents, Occupational; D000396:Air Pollutants, Radioactive / Q000493:pharmacokinetics* / Q000633:toxicity; D003037:Cobalt Radioisotopes / Q000493:pharmacokinetics* / Q000633:toxicity; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D019570:Inhalation Exposure; D008168:Lung / Q000378:metabolism / Q000528:radiation effects*; D009928:Organ Specificity / Q000502:physiology / Q000528:radiation effects*; D012189:Retrospective Studies; D018570:Risk Assessment; D013997:Time Factors
chemical_list: D000396:Air Pollutants, Radioactive; D003037:Cobalt Radioisotopes