Synthesis and in vivo antihyperglycemic activity of nature-mimicking furanyl-2-pyranones in STZ-S model.
Various nature-mimicking pyranones such as 6-(2,5-dimethylfuran-3-yl)-pyran-2-one and 6-(furan-2-yl)-pyran-2-one derivatives were synthesized and evaluated for their in vivo antihyperglycemic activity in sucrose-loaded streptozotocin-induced diabetic rat model. Five of the test compounds showed significant lowering of plasma glucose level in STZ-S model.
Singh
Fateh V
FV
Division of Medicinal Chemistry, Central Drug Research Institute, Lucknow 226001, India.
Chaurasia
Sumit
S
Joshi
Maya D
MD
Srivastava
Arvind K
AK
Goel
Atul
A
D000818:Animals; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D015195:Drug Design; D005663:Furans / Q000737:chemistry*; D006943:Hyperglycemia / Q000188:drug therapy*; D007004:Hypoglycemic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D008297:Male; D008956:Models, Chemical; D008968:Molecular Conformation; D010936:Plant Extracts / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry; D011714:Pyrans / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013311:Streptozocin / Q000737:chemistry
D005663:Furans; D007004:Hypoglycemic Agents; D010936:Plant Extracts; D011714:Pyrans; D013311:Streptozocin