[Recent progress in the stimulation of the histiocyte system and the anti-infection defences. Research into the effect of stanozolol treatment on the phagocyte activity of human macrophages].
A group of patients was treated with stanozolol. A modified version of Roebuck's skin window technique was used to obtain macrophages. These were then fixed in vitro with a suspension of Paracolonbacter aerogenoides. Comparison with a group of control subjects showed that the macrophages from the treated patients appeared to take up and destroy germs more effectively and that this could be potentiated by prior opsonisation with serum from the treated subjects. These results are seen as an expression of functional activation of the macrophages and an increase in serum opsonin content.
Fiori
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GP
Istituto di Malattie Infettive dell'Università di Pavia.
Azzareiti
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G
Dionisi
D
D
Lodola
E
E
D000368:Aged; D045930:Anabolic Agents / Q000494:pharmacology*; D006644:Histiocytes / Q000276:immunology*; D006801:Humans; D008264:Macrophages / Q000187:drug effects* / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D010587:Phagocytosis / Q000187:drug effects*; D013197:Stanozolol / Q000494:pharmacology*
D045930:Anabolic Agents; D013197:Stanozolol