Models of liver fibrosis: exploring the dynamic nature of inflammation and repair in a solid organ.
Models of liver fibrosis, which include cell culture models, explanted and biopsied human material, and experimental animal models, have demonstrated that liver fibrosis is a highly dynamic example of solid organ wound healing. Recent work in human and animal models has shown that liver fibrosis is potentially reversible and, in specific circumstances, demonstrates resolution with a restoration of near normal architecture. This Review highlights the manner in which studies of models of liver fibrosis have contributed to the paradigm of dynamic wound healing in this solid organ.
Iredale
John P
JP
Medical Research Council/University of Edinburgh Centre for Inflammation Research, Queen's Medical Research Institute, Edinburgh, United Kingdom. John.Iredale@ed.ac.uk
D000818:Animals; D004195:Disease Models, Animal; D005109:Extracellular Matrix; D005347:Fibroblasts / Q000502:physiology*; D006801:Humans; D007249:Inflammation / Q000473:pathology; D008103:Liver Cirrhosis / Q000473:pathology; D008106:Liver Cirrhosis, Experimental / Q000276:immunology* / Q000473:pathology*; D008115:Liver Regeneration; D008954:Models, Biological; D014945:Wound Healing