[Preparation of inclusion complex of daidzein and hydropropyl-beta-cyclodextrin].
OBJECTIVE
To prepare an inclusion complex of daidzein and hydropropyl-beta-cyclodextrin to enhance the solubility of daidzein.


METHODS
The inclusion complex of daidzein was prepared by the solution stirring method. The binary system of daidzein and HP-beta-CD was confirmed by differential thermal, thermogravimetry analysis, infrared spectroscopy and X-ray diffractometry.


RESULTS
The drug content in the inclusion complex was 6. 76% and the solubility was 13.68 mg x mL(-1). The identification results showed that the inclusion complex was formed.


CONCLUSIONS
The preparation method of the inclusion complex of daidzein and hydropropyl-beta-cyclodextrin is simple and available, with a increased solubility of daidzein.
Ge
Yue-Bin
YB
Center of Ocean, Department of Biology Sciences and Biotechnology, Tsinghua University, Beijing 100084, China.
Chen
Da-Wei
DW
Xie
Li-Ping
LP
Wang
Hong-Zhong
HZ
Zheng
Gui-Lan
GL
Zhang
Rong-Qing
RQ
D000073738:2-Hydroxypropyl-beta-cyclodextrin; D004055:Differential Thermal Analysis; D004339:Drug Compounding / Q000379:methods*; D007529:Isoflavones / Q000737:chemistry*; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared; D014961:X-Ray Diffraction; D047392:beta-Cyclodextrins / Q000737:chemistry*
D007529:Isoflavones; D047392:beta-Cyclodextrins; D000073738:2-Hydroxypropyl-beta-cyclodextrin; C004742:daidzein