title: Fully automated flow-through synthesis of secondary sulfonamides in a binary reactor system.
abstract: A fully automated flow-through process for the production of secondary sulfonamides is presented. Primary sulfonamides were monoalkylated using a two-step "catch and release" protocol to generate library products of high purity. The automated flow synthesis platform incorporates four independent reactor columns and is able to perform automated column regeneration. A 48-member sulfonamide library was prepared as two 24-member sublibraries, affording library compounds in good yields and high purities without the need for further column chromatographic purification.
authors.affiliation: GlaxoSmithKline Cambridge Technology Centre, University Chemical Laboratory, Lensfield Road, Cambridge, CB2 1EW, UK.
authors.forename: Charlotte M
authors.initials: CM
authors.lastname: Griffiths-Jones
authors.forename: Mark D
authors.initials: MD
authors.lastname: Hopkin
authors.forename: Daniel
authors.initials: D
authors.lastname: Jönsson
authors.forename: Steven V
authors.initials: SV
authors.lastname: Ley
authors.forename: David J
authors.initials: DJ
authors.lastname: Tapolczay
authors.forename: Emma
authors.initials: E
authors.lastname: Vickerstaffe
authors.forename: Mark
authors.initials: M
authors.lastname: Ladlow
mesh_terms: D020650:Combinatorial Chemistry Techniques / Q000295:instrumentation / Q000379:methods*; D015394:Molecular Structure; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000737:chemistry; D013997:Time Factors
chemical_list: D013449:Sulfonamides