Taurocholic acid does not induce apoptosis in HCT116 cells regardless of its intracellular concentration.
Hydrophobic bile acids but not hydrophilic bile acids induce apoptosis in HCT116 cells. We expressed sodium-dependent bile acid transporters in HCT116 cells, and the intracellular concentration of hydrophilic bile acids increased to that of the hydrophobic bile acids. But no sign of apoptosis was observed, which suggests a hydrophobic-bile acid-specific mechanism for the induction of apoptosis in HCT116 cells.
Yui
Satoko
S
Laboratory of Molecular Nutrition, Department of Biological Function, Kyoto Prefectural University, Kyoto, Japan.
Kanamoto
Ryuhei
R
Iwami
Kimikazu
K
Saeki
Tohru
T
D017209:Apoptosis / Q000187:drug effects / Q000502:physiology*; D001647:Bile Acids and Salts / Q000494:pharmacology*; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism*; D045325:HCT116 Cells; D006801:Humans; D007424:Intracellular Fluid / Q000378:metabolism*; D008562:Membrane Glycoproteins / Q000235:genetics / Q000378:metabolism*; D013656:Taurocholic Acid / Q000494:pharmacology*
D001647:Bile Acids and Salts; D002352:Carrier Proteins; D008562:Membrane Glycoproteins; C037643:bile acid binding proteins; D013656:Taurocholic Acid