title: Borreliacidal OspC antibody response of canines with Lyme disease differs significantly from that of humans with Lyme disease.
abstract: Humans reliably produce high concentrations of borreliacidal OspC antibodies specific for the seven C-terminal amino acids shortly after infection with Borrelia burgdorferi. We show that dogs also produce OspC borreliacidal antibodies but that their frequencies, intensities, and antigenicities differ significantly. The findings therefore confirm a major difference between the borreliacidal antibody responses of humans and canines with Lyme disease.
authors.affiliation: Microbiology Research Laboratory, Gundersen Lutheran Medical Center, 1300 Badger Street, La Crosse, Wisconsin 54601, USA.
authors.forename: Steven D
authors.initials: SD
authors.lastname: Lovrich
authors.forename: Rhonda L
authors.initials: RL
authors.lastname: La Fleur
authors.forename: Dean A
authors.initials: DA
authors.lastname: Jobe
authors.forename: Jennifer C
authors.initials: JC
authors.lastname: Johnson
authors.forename: Krista E
authors.initials: KE
authors.lastname: Asp
authors.forename: Ronald F
authors.initials: RF
authors.lastname: Schell
authors.forename: Steven M
authors.initials: SM
authors.lastname: Callister
mesh_terms: D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood*; D000942:Antigens, Bacterial / Q000097:blood / Q000276:immunology*; D001425:Bacterial Outer Membrane Proteins / Q000097:blood / Q000276:immunology*; D001426:Bacterial Proteins / Q000097:blood / Q000276:immunology*; D026481:Blotting, Far-Western; D025065:Borrelia burgdorferi / Q000276:immunology*; D004285:Dogs; D006801:Humans; D008074:Lipoproteins / Q000097:blood / Q000276:immunology*; D008193:Lyme Disease / Q000097:blood / Q000276:immunology*
chemical_list: D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D001425:Bacterial Outer Membrane Proteins; D001426:Bacterial Proteins; D008074:Lipoproteins; C079616:OspC protein; C084998:OspE protein, Borrelia burgdorferi