title: Time course of tissue remodelling and electrophysiology in the rat sciatic nerve after spiral cuff electrode implantation.
abstract: Implantation of nerve cuff electrodes induces inflammatory cell infiltration and loose connective tissue accumulation. Along with time, morphological changes evolve towards a thicker epi/perineurium as part of mechanisms that protect nerve functionality when a foreign body is wrapped around it. The rise in electrode impedance is linked to the nature of the epineurial tissue. Changes involve an increased expression of neuroprotective factors that is stronger in the endoneurium with axonal degeneration. Our data indicate that epineurial and endoneurial changes after electrode cuff implantation are part of axonal protection mechanisms. Their control is important to improve the yield of FES applications.
authors.affiliation: Laboratoire de Morphologie Expérimentale, Department of Physiology and Pharmacology, Université catholique de Louvain, Medical School, Brussels, Belgium.
authors.forename: Marie-Anne
authors.initials: MA
authors.lastname: Thil
authors.forename: Dai Tran
authors.initials: DT
authors.lastname: Duy
authors.forename: Ides M
authors.initials: IM
authors.lastname: Colin
authors.forename: Jean
authors.initials: J
authors.lastname: Delbeke
mesh_terms: D000818:Animals; D017097:Electric Impedance; D004567:Electrodes, Implanted / Q000009:adverse effects*; D004576:Electromyography / Q000295:instrumentation*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012584:Sciatic Nerve / Q000378:metabolism* / Q000473:pathology*; D013997:Time Factors