title: Relationship between diet and anticoagulant response to warfarin: a factor analysis.
abstract: BACKGROUND
  Diet composition is one of the factors that may contribute to intraindividual variability in the anticoagulant response to warfarin.
  
  
  OBJECTIVE
  To determine the associations between food pattern and anticoagulant response to warfarin in a group of Brazilian patients with vascular disease.
  
  
  METHODS
  Recent and usual food intakes were assessed in 115 patients receiving warfarin; and corresponding plasma phylloquinone (vitamin K(1)), serum triglyceride concentrations, prothrombin time (PT), and International Normalized Ratio (INR) were determined. A factor analysis was used to examine the association of specific foods and biochemical variables with anticoagulant data.
  
  
  RESULTS
  Mean age was 59 +/- 15 years. Inadequate anticoagulation, defined as values of INR 2 or 3, was found in 48% of the patients. Soybean oil and kidney beans were the primary food sources of phylloquinone intake. Factor analysis yielded four separate factors, explaining 56.4% of the total variance in the data set. The factor analysis revealed that intakes of kidney beans and soybean oil, 24-h recall of phylloquinone intake, PT and INR loaded significantly on factor 1. Triglycerides, PT, INR, plasma phylloquinone, and duration of anticoagulation therapy loaded on factor 3.
  
  
  CONCLUSIONS
  Fluctuations in phylloquinone intake, particularly from kidney beans, and plasma phylloquinone concentrations were associated with variation in measures of anticoagulation (PT and INR) in a Brazilian group of patients with vascular disease.
authors.affiliation: Depto. de Nutrição e Dietética da Faculdade de Nutrição, Universidade Federal Fluminense (UFF), Rua São Paulo, 30/4 andar. Centro, Niterói, RJ 24015-110, Brazil. silviam@vm.uff.br
authors.forename: Silvia Maria
authors.initials: SM
authors.lastname: Custódio das Dôres
authors.forename: Sarah L
authors.initials: SL
authors.lastname: Booth
authors.forename: Ligia Araújo
authors.initials: LA
authors.lastname: Martini
authors.forename: Ligia
authors.initials: L
authors.lastname: Aújo Martini
authors.forename: Victor Hugo
authors.initials: VH
authors.lastname: de Carvalho Gouvêa
authors.forename: Carlos Roberto
authors.initials: CR
authors.lastname: Padovani
authors.forename: Francisco Humberto
authors.initials: FH
authors.lastname: de Abreu Maffei
authors.forename: Alvaro Oscar
authors.initials: AO
authors.lastname: Campana
authors.forename: Sérgio Alberto
authors.initials: SA
authors.lastname: Rupp de Paiva
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000925:Anticoagulants / Q000494:pharmacology*; D000933:Antifibrinolytic Agents / Q000008:administration & dosage / Q000097:blood; D001777:Blood Coagulation / Q000187:drug effects* / Q000502:physiology; D004032:Diet; D005163:Factor Analysis, Statistical; D005260:Female; D006801:Humans; D019934:International Normalized Ratio; D008297:Male; D008875:Middle Aged; D011517:Prothrombin Time; D011795:Surveys and Questionnaires; D014280:Triglycerides / Q000097:blood; D014652:Vascular Diseases / Q000097:blood / Q000188:drug therapy; D010837:Vitamin K 1 / Q000008:administration & dosage / Q000097:blood; D014859:Warfarin / Q000494:pharmacology*
chemical_list: D000925:Anticoagulants; D000933:Antifibrinolytic Agents; D014280:Triglycerides; D014859:Warfarin; D010837:Vitamin K 1