title: Physics-based subsurface visualization of human tissue.
abstract: In this paper, we present a framework for simulating light transport in three-dimensional tissue with inhomogeneous scattering properties. Our approach employs a computational model to simulate light scattering in tissue through the finite element solution of the diffusion equation. Although our model handles both visible and nonvisible wavelengths, we especially focus on the interaction of near infrared (NIR) light with tissue. Since most human tissue is permeable to NIR light, tools to noninvasively image tumors, blood vasculature, and monitor blood oxygenation levels are being constructed. We apply this model to a numerical phantom to visually reproduce the images generated by these real-world tools. Therefore, in addition to enabling inverse design of detector instruments, our computational tools produce physically-accurate visualizations of subsurface structures.
authors.affiliation: Department of Computer and Information Science, The Ohio State University, Columbus 43212, USA. sharpr@cse.ohio-state.edu
authors.forename: Richard
authors.initials: R
authors.lastname: Sharp
authors.forename: Jacob
authors.initials: J
authors.lastname: Adams
authors.forename: Raghu
authors.initials: R
authors.lastname: Machiraju
authors.forename: Robert
authors.initials: R
authors.lastname: Lee
authors.forename: Robert
authors.initials: R
authors.lastname: Crane
mesh_terms: D055592:Biophysical Phenomena; D001703:Biophysics; D003196:Computer Graphics; D003198:Computer Simulation; D005542:Forearm / Q000033:anatomy & histology / Q000098:blood supply; D006801:Humans; D007259:Infrared Rays; D008953:Models, Anatomic; D055095:Optics and Photonics; D019047:Phantoms, Imaging; D012542:Scattering, Radiation