Spatio-temporal brain dynamics underlying saccade execution, suppression, and error-related feedback.
Human and nonhuman animal research has outlined the neural regions that support saccadic eye movements. The aim of the current work was to outline the sequence by which distinct neural regions come on-line to support goal-directed saccade execution and error-related feedback. To achieve this, we obtained behavioral responses via eye movement recordings and neural responses via magnetoencephalography (MEG), concurrently, while participants performed an antisaccade task. Neural responses were examined with respect to the onset of the saccadic eye movements. Frontal eye field and visual cortex activity distinguished subsequently successful goal-directed saccades from (correct and erroneous) reflexive saccades prior to the deployment of the eye movement. Activity in the same neural regions following the saccadic movement distinguished correct from incorrect saccadic responses. Error-related activity in the frontal eye fields preceded that from visual regions, suggesting a potential feedback network that may drive corrective eye movements. This work provides the first empirical demonstration of simultaneous remote eyetracking and MEG recording. The coupling of behavioral and neuroimaging technologies, used here to characterize dynamic brain networks underlying saccade execution and error-related feedback, demonstrates a novel within-paradigm converging evidence approach by which to outline the neural underpinnings of cognition.
Herdman
Anthony T
AT
Rotman Research Institute, Baycrest, Toronto, ON, Canada.
Ryan
Jennifer D
JD
D000328:Adult; D001921:Brain / Q000502:physiology*; D003071:Cognition / Q000502:physiology; D004574:Electromagnetic Fields; D005133:Eye Movements / Q000502:physiology; D030141:Feedback, Psychological / Q000502:physiology*; D005260:Female; D006801:Humans; D015225:Magnetoencephalography; D008297:Male; D009415:Nerve Net / Q000502:physiology; D011597:Psychomotor Performance / Q000502:physiology; D012438:Saccades / Q000502:physiology*; D014793:Visual Cortex / Q000502:physiology; D014794:Visual Fields / Q000502:physiology