An unusual cause of granulomatous disease.
BACKGROUND
Chronic granulomatous disease (CGD) is an inherited disorder of phagocytic cells caused by an inability to generate active microbicidal oxygen species required kill certain types of fungi and bacteria. This leads to recurrent life-threatening bacterial and fungal infections with tissue granuloma formation.


METHODS
We describe a case of X-linked Chronic granulomatous disease (CGD) diagnosed in an 18-year-old male. He initially presented with granulomatous disease mimicking sarcoidosis and was treated with corticosteroids. He subsequently developed Burkholderia cepacia complex pneumonia and further investigation confirmed a diagnosis of CGD.


CONCLUSIONS
Milder phenotypes of CGD are now being recognised. CGD should be considered in patients of any age with granulomatous diseases, especially if there is a history of recurrent or atypical infection.
McLean-Tooke
Andrew P C
AP
Department of Immunology, Royal Victoria Infirmary, Newcastle-Upon-Tyne, UK. andrew.mclean-tooke@nuth.northy.nus.uk
Aldridge
Catherine
C
Gilmour
Kimberley
K
Higgins
Bernard
B
Hudson
Mark
M
Spickett
Gavin P
GP