title: Laryngeal solitary fibrous tumour.
abstract: Solitary fibrous tumours (SFT) are rare neoplasms, with an uncommon laryngeal involvement. Only five cases of laryngeal localization have been described in literature. The following is a case of a 75-year-old man with a supraglottic neoplasm of the larynx; after the biopsy immunohistochemical study demonstrated a strong positivity for vimentin, CD34 and Bcl-2. The neoplasm was consequently classified as a SFT. CO(2) laser surgery of the supraglottic larynx, with a wide excision of the neoplasm, was performed. Twenty-four months on, the patient is alive, well and free of disease. Surgical resection is the treatment of choice for laryngeal SFT, but tumour-free resection margins must be achieved to prevent the possibility of local recurrence. Endoscopic resection by means of the CO(2) laser must be accurately planned with MRI or CT imaging to confirm of this kind of surgery.
authors.affiliation: ENT Department, University of Ferrara, St. Anna Hospital, Corso Giovecca 203, Ferrara, Italy. fstomeo@libero.it
authors.forename: Francesco
authors.initials: F
authors.lastname: Stomeo
authors.forename: Davide
authors.initials: D
authors.lastname: Padovani
authors.forename: Corrado
authors.initials: C
authors.lastname: Bozzo
authors.forename: Antonio
authors.initials: A
authors.lastname: Pastore
mesh_terms: D000368:Aged; D018952:Antigens, CD34 / Q000032:analysis; D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D004417:Dyspnea / Q000209:etiology; D005350:Fibroma / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D005500:Follow-Up Studies; D006801:Humans; D007822:Laryngeal Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D007828:Laryngoscopy; D053685:Laser Therapy; D008297:Male; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000032:analysis; D036542:Tomography, Spiral Computed
chemical_list: D018952:Antigens, CD34; D014408:Biomarkers, Tumor; D019253:Proto-Oncogene Proteins c-bcl-2