[Effect of Panax notoginseng saponins on serum neuronal specific enolase and rehabilitation in patients with cerebral hemorrhage].
OBJECTIVE
To observe the effect of Panax notoginseng saponins (PNS) on serum content of neuronal specific enolase (NSE) and function recovery in patients with cerebral hemorrhage (CH) for exploring the therapeutic action of PNS in treating CH.


METHODS
Fifty CH patients with their course of disease not more than 5 days were randomly assigned to two groups, 27 in the PNS group and 23 in the control group, all were treated with conventional treatment, while PNS was given additionally to the PNS group. The serum levels of NSE before and after treatment were determined by electrochemiluminescence, and the recovery of patients, including their neuro-function deficit and daily living activity, was assessed according to scoring by the National Institute of Health Stroke Scale (NIHSS) and Barthel Index (BI) respectively.


RESULTS
Before treatment, the difference between the two groups in serum NSE content and scores of NIHSS and BI was insignificant (P > 0.05). However, after 3 weeks of treatment, the level of NSE and score of NIHSS were significantly lower, while score of BI was significantly higher in the PNS group than those in the control group respectively (all P < 0.01). In the PNS group, the level of NSE showed a positive correlation with the score of NIHSS (r = 0.757, P < 0.05), and a negative correlation with the score of BI (r = - 0.803, P < 0.05).


CONCLUSIONS
PNS can effectively protect the neuron and promote functional rehabilitation in patients after CH.
Wei
Shi-Ge
SG
Department of Neurology, Affiliated Hospital of Youjiang Medical College for Nationalities, Guangxi.
Meng
Lan-Qing
LQ
Huang
Rui-Ya
RY
D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D002543:Cerebral Hemorrhage / Q000097:blood / Q000188:drug therapy* / Q000534:rehabilitation; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D053723:Panax notoginseng / Q000737:chemistry*; D010751:Phosphopyruvate Hydratase / Q000097:blood*; D008517:Phytotherapy; D012503:Saponins / Q000627:therapeutic use*; D016896:Treatment Outcome
D015415:Biomarkers; D012503:Saponins; D010751:Phosphopyruvate Hydratase