title: A polymorphism of the interleukin-1 beta gene is associated with sperm pathology in humans.
abstract: In a prospective case-control study of 127 normozoospermic and 435 non-normozoospermic Caucasian men, the genotype frequencies of a polymorphism of the interleukin-1 beta gene (IL-1beta Taq C-->T) were statistically significantly different between groups (homozygous wild-type C/C [57%], heterozygous C/T [42%], and homozygous mutant T/T [1%] vs. C/C [57%], C/T [36%], T/T [7%] for normozoospermic and non-normozoospermic men, respectively; odds ratio, 4.8; 95% confidence interval, 1.13 to 20.28). This association was restricted to men with the oligoasthenoteratozoospermia (OAT) syndrome. We conclude that the investigated polymorphism is associated with sperm pathology in Caucasians.
authors.affiliation: Departments of Gynecologic Endocrinology and Reproductive Medicine, University of Vienna School of Medicine, Vienna, Austria. eva-katrin.bentz@meduniwien.ac.at <eva-katrin.bentz@meduniwien.ac.at>
authors.forename: Eva-Katrin
authors.initials: EK
authors.lastname: Bentz
authors.forename: Lukas A
authors.initials: LA
authors.lastname: Hefler
authors.forename: Dominik
authors.initials: D
authors.lastname: Denschlag
authors.forename: Detlef
authors.initials: D
authors.lastname: Pietrowski
authors.forename: Bernd
authors.initials: B
authors.lastname: Buerkle
authors.forename: Clemens B
authors.initials: CB
authors.lastname: Tempfer
mesh_terms: D053713:Azoospermia / Q000235:genetics / Q000473:pathology; D006801:Humans; D053583:Interleukin-1beta / Q000235:genetics*; D008297:Male; D011110:Polymorphism, Genetic; D012016:Reference Values; D013094:Spermatozoa / Q000473:pathology*
chemical_list: D053583:Interleukin-1beta