[Kinetics of Ca2+, NADH, and oxidized flavoproteins in the frog olfactory lining under the effect of odorants].
The kinetics of fluorescence of Ca(2+) - chlortertacyclin-cell membrane complex as well as of NADH and oxidized flavoproteins in receptor cells of the frog olfactory lining under the effect of odorants has been studied. Changes in the fluorescence of the olfactory lining upon stimulation by cineole and vanillin occurred more rapidly than under the effect of camphor and amyl alcohol. Differences in the kinetics of reactions of NADH and the Ca(2+)-CTC-CM complex to different odorants are apparently due to heterogeneity of molecular mechanisms associated with the involvement of different intracellular signal systems in the transduction of these odorants in the olfactory lining. In contrast to them, ammonia and beta3-mercaptoethanol penetrate into olfactory cells and inhibit the mitochondrial respiratory chain without the participation of second messengers. At the same time, the motor activity of olfactory cilia is depressed.
Rudenko
Ia N
IaN
Bigdaĭ
E V
EV
Samoĭlov
V O
VO
D000818:Animals; D000891:Anti-Infective Agents, Local / Q000494:pharmacology; D000975:Antioxidants / Q000494:pharmacology; D001547:Benzaldehydes / Q000494:pharmacology; D020013:Calcium Signaling / Q000187:drug effects*; D002164:Camphor; D003511:Cyclohexanols / Q000494:pharmacology; D004579:Electron Transport / Q000187:drug effects; D000077591:Eucalyptol; D005420:Flavoproteins / Q000378:metabolism*; D007700:Kinetics; D008928:Mitochondria / Q000378:metabolism*; D039821:Monoterpenes / Q000494:pharmacology; D009243:NAD / Q000378:metabolism*; D009812:Odorants; D009831:Olfactory Mucosa / Q000378:metabolism; D018034:Olfactory Receptor Neurons / Q000378:metabolism*; D010084:Oxidation-Reduction / Q000187:drug effects; D000439:Pentanols; D011896:Rana temporaria; D018035:Receptors, Odorant / Q000378:metabolism; D012997:Solvents / Q000494:pharmacology
D000891:Anti-Infective Agents, Local; D000975:Antioxidants; D001547:Benzaldehydes; D003511:Cyclohexanols; D005420:Flavoproteins; D039821:Monoterpenes; D000439:Pentanols; D018035:Receptors, Odorant; D012997:Solvents; D009243:NAD; D002164:Camphor; C100058:vanillin; D000077591:Eucalyptol