Homozygous factor V Leiden mutation and disseminated thrombosis in a patient with nephrotic syndrome.
We report the case of a young male patient with nephrotic syndrome and multiple venous thromboses. The patient presented various aggregated thrombophilic risk factors. He was found to be homozygous for factor V Leiden mutation and his anticardiolipin antibody and homocysteine levels were high. The association between nephrotic syndrome and venous thrombosis is well known. However the presence of disseminated thrombosis should prompt an intensive work-up for the detection of thrombotic risk factors and aggressive anticoagulant therapy.
Kahveci
Arzu
A
Division of Nephrology, Department of Internal Medicine, Cerrahpasa Medical Faculty, Istanbul University, Istanbul - Turkey.
Seyahi
Nurhan
N
Seyahi
Emire
E
Altiparmak
Mehmet R
MR
Ataman
Rezzan
R
Serdengecti
Kamil
K
D000328:Adult; D017153:Antibodies, Anticardiolipin / Q000097:blood; D000925:Anticoagulants / Q000627:therapeutic use; D025861:Blood Coagulation Disorders, Inherited / Q000188:drug therapy / Q000235:genetics; D004211:Disseminated Intravascular Coagulation / Q000188:drug therapy / Q000235:genetics; D005165:Factor V / Q000235:genetics*; D006710:Homocysteine / Q000097:blood; D006720:Homozygote; D006801:Humans; D008297:Male; D009154:Mutation / Q000235:genetics*; D009404:Nephrotic Syndrome / Q000150:complications*; D012307:Risk Factors; D020246:Venous Thrombosis / Q000188:drug therapy / Q000235:genetics*
D017153:Antibodies, Anticardiolipin; D000925:Anticoagulants; C095381:factor V Leiden; D006710:Homocysteine; D005165:Factor V