title: [The action of decorin in anti-fibrosis and anti-cancer].
abstract: Decorin (DCN) is a member of the small leucine-rich proteoglycan gene family. Many studies indicated that DCN inhibited fibrosis and scar-formation by neutralization of TGF-P and interfering the binding of TGF-beta with its receptor, which induced ectopic deposition of extracellular matrix. Additionally, DCN can prevent the proliferation and metastasis of tumor cells by activating EGFR/MAPK/p21 signal pathway and inhibiting the cell proliferation pathway mediated by EGF-EGFR. It is suggested that the recombinant DCN had potential pharmaceutical potency in treatment of chronic fibrosis and neoplasm for its critical biological activities and low immunogenicity.
authors.affiliation: Key Laboratory for Biomechanics & Tissue Engineering of the State Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400044, China.
authors.forename: Weifeng
authors.initials: W
authors.lastname: Ma
authors.forename: Yi
authors.initials: Y
authors.lastname: Tan
authors.forename: Shaohui
authors.initials: S
authors.lastname: Cai
authors.forename: Hongyuan
authors.initials: H
authors.lastname: Chen
authors.forename: Jun
authors.initials: J
authors.lastname: Du
authors.forename: Shaoxi
authors.initials: S
authors.lastname: Cai
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D058575:Decorin; D066246:ErbB Receptors / Q000037:antagonists & inhibitors; D016326:Extracellular Matrix Proteins / Q000737:chemistry* / Q000494:pharmacology*; D005355:Fibrosis / Q000517:prevention & control*; D006801:Humans; D011509:Proteoglycans / Q000737:chemistry* / Q000494:pharmacology*; D011994:Recombinant Proteins / Q000494:pharmacology; D053773:Transforming Growth Factor beta1 / Q000037:antagonists & inhibitors
chemical_list: D000970:Antineoplastic Agents; C546878:DCN protein, human; D058575:Decorin; D016326:Extracellular Matrix Proteins; D011509:Proteoglycans; D011994:Recombinant Proteins; D053773:Transforming Growth Factor beta1; D066246:ErbB Receptors