Auditory stimulation affects renal sympathetic nerve activity and blood pressure in rats.
Here, we examined the effects of auditory stimulation at 50 dB with white noise (WN) or music (Traeumerei [TM] by Schumann or Etude by Chopin) on renal sympathetic nerve activity (RSNA) and BP in urethane-anesthetized rats. Auditory stimulation with TM, but not with WN or the Etude, significantly decreased RSNA and BP. Complete bilateral destruction of the cochleae and bilateral lesions of the auditory cortex (AuC) eliminated the effects of TM stimulation on RSNA and BP, but bilateral lesions of primary somatosensory cortex (S1C) had no effect. Bilateral lesions of the hypothalamic suprachiasmatic nucleus (SCN) or intracerebral administration of thioperamide, a histaminergic H3 receptor antagonist, also abolished TM-induced decreases in RSNA and BP. These findings suggest that exposure to music can decrease RSNA and BP through the auditory pathway, histaminergic neurons, and the SCN.
Nakamura
Takuo
T
Institute for Protein Research, Osaka University, 3-2 Yamada-Oka, Suita, Osaka 565-0871, Japan.
Tanida
Mamoru
M
Niijima
Akira
A
Hibino
Hiroshi
H
Shen
Jiao
J
Nagai
Katsuya
K
D000161:Acoustic Stimulation; D000818:Animals; D001306:Auditory Pathways / Q000378:metabolism*; D001794:Blood Pressure / Q000502:physiology*; D006632:Histamine / Q000378:metabolism; D007668:Kidney / Q000294:innervation / Q000378:metabolism*; D008297:Male; D009146:Music; D009474:Neurons / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013493:Suprachiasmatic Nucleus / Q000378:metabolism*; D013564:Sympathetic Nervous System / Q000502:physiology*
D006632:Histamine