title: Antinociceptive effect and acute toxicity of the essential oil of Hyptis fruticosa in mice.
abstract: The essential oil of the Hyptis fruticosa leaves was analyzed by GC/MS and evaluated for antinociceptive property as well as acute toxicity in mice. The essential oil, at doses of 100, 200, and 400 mg/kg (s.c.), produced significant inhibition of acetic acid-induced writhing, but did not manifest a significant effect in hot-plate test. There was no acute toxicity at doses up to 5 g/kg. Bicyclogermacrene, 1,8-cineole, alpha-pinene, and beta-caryophyllene were the major compounds detected in the essential oil.
authors.affiliation: Physiology Department, Federal University of Sergipe, São Cristovão, Brazil. igormenezes@bol.com.br
authors.forename: Igor A C
authors.initials: IA
authors.lastname: Menezes
authors.forename: Maxsuel S
authors.initials: MS
authors.lastname: Marques
authors.forename: Thiago C
authors.initials: TC
authors.lastname: Santos
authors.forename: Kellyane S
authors.initials: KS
authors.lastname: Dias
authors.forename: Aline B L
authors.initials: AB
authors.lastname: Silva
authors.forename: Iderjane C M
authors.initials: IC
authors.lastname: Mello
authors.forename: Ana C C D
authors.initials: AC
authors.lastname: Lisboa
authors.forename: Péricles B
authors.initials: PB
authors.lastname: Alves
authors.forename: Sócrates C H
authors.initials: SC
authors.lastname: Cavalcanti
authors.forename: Rosilene M
authors.initials: RM
authors.lastname: Marçal
authors.forename: Angelo R
authors.initials: AR
authors.lastname: Antoniolli
mesh_terms: D019342:Acetic Acid; D000700:Analgesics / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D006358:Hot Temperature; D031331:Hyptis; D008297:Male; D051379:Mice; D010146:Pain / Q000139:chemically induced / Q000517:prevention & control*; D010147:Pain Measurement / Q000187:drug effects; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D000700:Analgesics; D010936:Plant Extracts; D019342:Acetic Acid