Frequency of cytokine gene promoter polymorphisms in the Northern Ireland cystic fibrosis population.
It has been postulated that cytokine allele frequencies are gender and perhaps geographically-specific. Cytokine release is crucial in the regulation of the type and magnitude of the immune response. This study observed no differences in the frequency of cytokine promoter polymorphisms associated with variant levels of expression in patients with CF and a non-CF population of Northern Ireland.
Watt
Alison P
AP
Respiratory Research Group, The Queen's University of Belfast, United Kingdom. Alison.Watt@bll.n-i.nhs.uk
Ross
Owen A
OA
Courtney
Julia
J
Middleton
Derek
D
Ennis
Madeleine
M
Elborn
J Stuart
JS
D000328:Adult; D003550:Cystic Fibrosis / Q000453:epidemiology / Q000235:genetics*; D016207:Cytokines / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D006801:Humans; D008297:Male; D008875:Middle Aged; D009660:Northern Ireland / Q000453:epidemiology; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic / Q000235:genetics*
D016207:Cytokines