Selected important fragrance sensitizers in perfumes--current exposures.
Contact allergy to fragrance ingredients is frequent. Recommendations and regulations of some of the most frequent and potent fragrance allergens have recently been introduced. To investigate current exposures to 4 important fragrance allergens in hydroalcoholic cosmetic products. 25 popular perfume products of Danish as well as international brands were purchased from the Danish retail market. Contents of 4 important fragrance allergens, isoeugenol, hydroxy-iso-hexyl 3-cyclohexene carboxaldehyde (HICC, Lyral), were determined by gas chromatography-mass spectrometry, and atranol and chloro-atranol were determined by liquid chromatography-tandem mass spectrometry. Isoeugenol was found in 56%, HICC in 72%, atranol in 59%, and chloro-atranol in 36% of the 22 eau de toilette/eau de parfum products. The concentrations of isoeugenol were, in all products, below the recommended maximum concentration of 0.02%. HICC reached a maximum of 0.2%, which is 10-fold higher than maximum tolerable concentration considered safe by the EU Scientific Committee. The median concentrations of atranol and chloro-atranol in the investigated products were similar to those found in similar products in 2003. A significant decrease in the frequency of presence of chloro-atranol in the products was observed. There is still a wide-spread exposure to potent fragrance allergens in perfumes.
Rastogi
Suresh Chandra
SC
Department of Environmental Chemistry and Microbiology, National Environmental Research Institute, Frederiksborgvej 399, DK-4000 Roskilde, Denmark. scr@dmu.dk
Johansen
Jeanne Duus
JD
Bossi
Rossana
R
D000447:Aldehydes / Q000032:analysis; D000485:Allergens / Q000032:analysis*; D001547:Benzaldehydes / Q000032:analysis; D002853:Chromatography, Liquid; D053138:Cyclohexenes / Q000032:analysis; D003718:Denmark; D017449:Dermatitis, Allergic Contact / Q000209:etiology*; D005054:Eugenol / Q000031:analogs & derivatives / Q000032:analysis; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D010476:Perfume / Q000737:chemistry*
D000447:Aldehydes; D000485:Allergens; D001547:Benzaldehydes; D053138:Cyclohexenes; D010476:Perfume; C493895:atranol; C487450:chloroatranol; D005054:Eugenol; C036643:isoeugenol; C092244:hydroxyisohexyl 3-cyclohexene carboxaldehyde