title: [Application of proteomics to neurological diseases].
abstract: Proteomic is a set of tools that allows the separation and identification of proteins expressed by a cell, tissue or organism. Two-dimensional electrophoresis is the central tool that allows qualitative and quantitative comparisons of protein patterns between samples. Differential analysis of protein expression patterns in different neurological diseases (stroke, Alzheimer, Parkinson, amyotrophic lateral sclerosis, Hungtington, epilepsy) allows the identification of diagnostic and/or prognostic biomarkers. Subsequently, validation of these markers may help to identify new diagnostic and therapeutic targets.
authors.affiliation: Laboratorio de Investigación Neurovascular, Hospital Clínico Universitario, Universidad de Santiago de Compostela, Santiado de Compostela.
authors.forename: D
authors.initials: D
authors.lastname: Brea
authors.forename: I
authors.initials: I
authors.lastname: Cristobo
authors.forename: T
authors.initials: T
authors.lastname: Sobrino
authors.forename: R
authors.initials: R
authors.lastname: Rodríguez-González
authors.forename: E
authors.initials: E
authors.lastname: Mosquera
authors.forename: O
authors.initials: O
authors.lastname: Moldes
authors.forename: J
authors.initials: J
authors.lastname: Castillo
mesh_terms: D000544:Alzheimer Disease / Q000235:genetics / Q000378:metabolism; D000690:Amyotrophic Lateral Sclerosis / Q000235:genetics / Q000378:metabolism; D002478:Cells, Cultured / Q000378:metabolism; D002853:Chromatography, Liquid / Q000379:methods; D015180:Electrophoresis, Gel, Two-Dimensional; D004827:Epilepsy / Q000235:genetics / Q000378:metabolism; D020869:Gene Expression Profiling / Q000379:methods; D005786:Gene Expression Regulation; D006801:Humans; D006816:Huntington Disease / Q000235:genetics / Q000378:metabolism; D013058:Mass Spectrometry / Q000379:methods; D009419:Nerve Tissue Proteins / Q000032:analysis / Q000096:biosynthesis / Q000235:genetics; D009422:Nervous System Diseases / Q000175:diagnosis / Q000235:genetics / Q000378:metabolism*; D011506:Proteins / Q000032:analysis* / Q000235:genetics; D040901:Proteomics / Q000379:methods*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D020521:Stroke / Q000235:genetics / Q000378:metabolism; D013382:Subtraction Technique
chemical_list: D009419:Nerve Tissue Proteins; D011506:Proteins