Protective effect of complex antioxidant preparation containing vitamins and amino acids in rats with burn trauma complicated by endotoxemia.
Burn trauma increased blood chemiluminescence, while lipopolysaccharide in a dose of 1 mg/kg potentiated this effect, activated LPO, and decreased plasma antioxidant activity. In erythrocytes, superoxide dismutase activity increased, while activity of peroxide-utilizing enzymes decreased. Myeloperoxidase content increased in the lungs and epidermis. The preparation of alpha-tocopherol, selenium aspartate, and ubiquinone abolished the effect of lipopolysaccharide, but did not modulate the increase in chemiluminescence under the influence of this agent.
Mikhal'chik
E V
EV
Department of Molecular Biology, Department of Physiology, Russian State Medical University, Moscow. lemik@zmail.ru
Titkova
S M
SM
Anurov
M V
MV
Ettinger
A P
AP
Korkina
L G
LG
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D002056:Burns / Q000150:complications*; D019446:Endotoxemia / Q000188:drug therapy* / Q000209:etiology*; D004817:Epidermis / Q000378:metabolism; D004912:Erythrocytes / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D008070:Lipopolysaccharides / Q000097:blood / Q000633:toxicity; D008163:Luminescent Measurements; D008168:Lung / Q000378:metabolism; D008297:Male; D009504:Neutrophils / Q000378:metabolism; D009195:Peroxidase / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D018036:Selenium Compounds / Q000627:therapeutic use; D013482:Superoxide Dismutase / Q000378:metabolism; D014451:Ubiquinone / Q000627:therapeutic use; D024502:alpha-Tocopherol / Q000627:therapeutic use
D000975:Antioxidants; D008070:Lipopolysaccharides; D018036:Selenium Compounds; D014451:Ubiquinone; D009195:Peroxidase; D013482:Superoxide Dismutase; D024502:alpha-Tocopherol