Anesthetic related advances with cyclodextrins.
Cyclodextrins encapsulate and electrostatically bind to lipophilic molecules. The exterior of cyclodextrins are water-soluble and maintain aqueous solubility despite encapsulation of non-aqueous soluble molecules. This unique ability to encapsulate lipophilic molecules and maintain water solubility confers numerous pharmacologic advantages for both drug delivery and removal. Cyclodextrins, a component part of supramolecular chemistry, may be in its infancy of anesthetic application but recent advances have been described as novel and revolutionary. A review of current research coupled with an understanding of cyclodextrin properties is necessary to fully appreciate the current uses and future potentials of these unique molecules.
Welliver
Mark
M
University of North Florida, Jacksonville, FL, USA.
McDonough
John
J
D000758:Anesthesia / Q000639:trends*; D000777:Anesthetics / Q000008:administration & dosage* / Q000737:chemistry; D002214:Capsules / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical / Q000379:methods* / Q000639:trends*; D003505:Cyclodextrins / Q000737:chemistry*; D004058:Diffusion; D004337:Drug Carriers / Q000737:chemistry*; D006801:Humans; D012995:Solubility
D000777:Anesthetics; D002214:Capsules; D003505:Cyclodextrins; D004337:Drug Carriers