title: First hypervalent iodine(III)-catalyzed C-N bond forming reaction: catalytic spirocyclization of amides to N-fused spirolactams.
abstract: A protic solvent, 2,2,2-trifluoroethanol (CF(3)CH(2)OH), was successfully introduced into hypervalent iodine(III)-involved catalytic cycles as an effective solvent, and the first iodoarene-catalyzed intramolecular carbon-nitrogen bond forming reaction was achieved under strong acid-free and mild conditions.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamada-oka, Suita, Osaka, 565-0871, Japan.
authors.forename: Toshifumi
authors.initials: T
authors.lastname: Dohi
authors.forename: Akinobu
authors.initials: A
authors.lastname: Maruyama
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Minamitsuji
authors.forename: Naoko
authors.initials: N
authors.lastname: Takenaga
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Kita
mesh_terms: D000577:Amides / Q000737:chemistry*; D002244:Carbon / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D007455:Iodine / Q000737:chemistry*; D007769:Lactams / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D009584:Nitrogen / Q000737:chemistry*
chemical_list: D000577:Amides; D007769:Lactams; D002244:Carbon; D007455:Iodine; D009584:Nitrogen