title: Cutaneous vascular alterations in psoriatic patients treated with cyclosporine.
abstract: Videocapillaroscopy can be used to assess cutaneous microcirculation modifications in vivo, and therefore allows assessment of variations in the microvascular architecture in psoriatic subjects during treatment. The aim of this study was to observe and quantify the modifications of the superficial capillary bed in psoriatic plaques during treatment with cyclosporin A. Twelve patients with psoriasis vulgaris were treated with an initial dose of 4 mg/kg/day cyclosporin A over a period of 3 months with periodic clinical and capillaroscopic assessments. Clinical resolution of the lesions and a reduction in microcirculatory alterations was observed in 70% of patients, although none returned to a normal capillaroscopic pattern.
authors.affiliation: Institute of Dermatology, Department of Clinical and Experimental Pathology and Medicine, University of Udine School of Medicine, Udine, Italy. giuseppe.stinco@uniud.it
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Stinco
authors.forename: Stefano
authors.initials: S
authors.lastname: Lautieri
authors.forename: Francesca
authors.initials: F
authors.lastname: Valent
authors.forename: Pasquale
authors.initials: P
authors.lastname: Patrone
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016572:Cyclosporine / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008833:Microcirculation / Q000187:drug effects; D020678:Microscopic Angioscopy / Q000379:methods; D008875:Middle Aged; D011565:Psoriasis / Q000188:drug therapy* / Q000503:physiopathology; D012867:Skin / Q000098:blood supply* / Q000187:drug effects
chemical_list: D016572:Cyclosporine