The role of CXC chemokines in pulmonary fibrosis.
The CXC chemokine family is a pleiotropic family of cytokines that are involved in promoting the trafficking of various leukocytes, in regulating angiogenesis and vascular remodeling, and in promoting the mobilization and trafficking of mesenchymal progenitor cells such as fibrocytes. These functions of CXC chemokines are important in the pathogenesis of pulmonary fibrosis and other fibroproliferative disorders. In this Review, we discuss the biology of CXC chemokine family members, specifically as it relates to their role in regulating vascular remodeling and trafficking of circulating mesenchymal progenitor cells (also known as fibrocytes) in pulmonary fibrosis.
Strieter
Robert M
RM
Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA 22908, USA. strieter@virginia.edu
Gomperts
Brigitte N
BN
Keane
Michael P
MP
D000595:Amino Acid Sequence; D049109:Cell Proliferation; D019743:Chemokines, CXC / Q000502:physiology*; D005347:Fibroblasts / Q000473:pathology / Q000502:physiology; D006801:Humans; D008168:Lung / Q000098:blood supply* / Q000473:pathology*; D008969:Molecular Sequence Data; D009389:Neovascularization, Pathologic / Q000209:etiology*; D011658:Pulmonary Fibrosis / Q000209:etiology* / Q000473:pathology; D013234:Stem Cells / Q000473:pathology / Q000502:physiology
D019743:Chemokines, CXC