Neuraminidase inhibitors improve outcome of patients with leukemia and influenza: an observational study.
We reviewed the records of 33 patients with leukemia who experienced influenza during the period from October 2000 to March 2004. Three (38%) of the 8 patients who did not receive neuraminidase inhibitor therapy and none of the 25 patients who received it died of influenza pneumonia (P=.001). The use of neuraminidase inhibitor therapy seems to improve the outcome of influenza in patients with leukemia.
Chemaly
Roy F
RF
Department of Infectious Diseases, Infection Control, and Employee Health, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77230-1402, USA. rfchemaly@mdanderson.org
Torres
Harrys A
HA
Aguilera
Elizabeth A
EA
Mattiuzzi
Gloria
G
Cabanillas
Maria
M
Kantarjian
Hagop
H
Gonzalez
Virginia
V
Safdar
Amar
A
Raad
Issam I
II
D000293:Adolescent; D000328:Adult; D000368:Aged; D000998:Antiviral Agents / Q000627:therapeutic use*; D015331:Cohort Studies; D015897:Comorbidity; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007251:Influenza, Human / Q000175:diagnosis / Q000188:drug therapy* / Q000453:epidemiology*; D007951:Leukemia, Myeloid / Q000175:diagnosis / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D009439:Neuraminidase / Q000037:antagonists & inhibitors* / Q000627:therapeutic use; D011336:Probability; D012189:Retrospective Studies; D018570:Risk Assessment; D015996:Survival Rate; D016896:Treatment Outcome
D000998:Antiviral Agents; D009439:Neuraminidase