title: Orthostatic myoclonus: a contributor to gait decline in selected elderly.
abstract: BACKGROUND
  We encountered 15 patients with a newly recognized clinical phenomenon that we term orthostatic myoclonus. We conducted a retrospective chart review to better understand the clinical context and importance of this phenomenon.
  
  
  OBJECTIVE
  To describe the clinical picture of orthostatic myoclonus.
  
  
  METHODS
  The Mayo Clinic Rochester Movement Disorders Laboratory database was searched for all patients diagnosed electrophysiologically with orthostatic myoclonus (2002 through 2006). Medical records and laboratory data of all patients were retrospectively reviewed.
  
  
  RESULTS
  Fifteen patients with orthostatic myoclonus were identified, all seniors (64 to 81 years). Seven of the patients had a CNS degenerative disorder and two had a systemic illness known to be associated with myoclonus. In the remaining six patients no known CNS disorder contributed to the phenomenon. The onset of orthostatic myoclonus was accompanied by complaints of leg jerking or observed leg jerking in 13 of 15 patients during upright posture. An insidious deterioration of gait that was often described as "apraxia" or "gait initiation difficulty" accompanied the myoclonus in 13 of 15 patients. Clinicians frequently suspected normal pressure hydrocephalus or orthostatic tremor syndrome. Surface EMG studies revealed short duration myoclonic bursts that occurred predominately with the assumption of an upright posture. Some patients improved on clonazepam.
  
  
  CONCLUSIONS
  Orthostatic myoclonus is a unique clinical and physiologic phenomenon that accompanies a slowly progressive and eventually disabling gait disorder in the elderly. This phenomenon often arises in the company of more widespread CNS disease.
authors.affiliation: Department of Neurology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA.
authors.forename: Graham A
authors.initials: GA
authors.lastname: Glass
authors.forename: J Eric
authors.initials: JE
authors.lastname: Ahlskog
authors.forename: Joseph Y
authors.initials: JY
authors.lastname: Matsumoto
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000927:Anticonvulsants / Q000627:therapeutic use; D002490:Central Nervous System / Q000503:physiopathology; D002998:Clonazepam / Q000627:therapeutic use; D003937:Diagnosis, Differential; D018450:Disease Progression; D004576:Electromyography; D005260:Female; D020233:Gait Disorders, Neurologic / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology*; D006801:Humans; D006850:Hydrocephalus, Normal Pressure / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology; D007866:Leg / Q000294:innervation / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000294:innervation / Q000503:physiopathology; D009207:Myoclonus / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology*; D009434:Neural Pathways / Q000503:physiopathology; D011187:Posture; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D014202:Tremor / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology
chemical_list: D000927:Anticonvulsants; D002998:Clonazepam