title: Aromatase expression in endometriotic tissues and its relationship to clinical and analytical findings.
abstract: OBJECTIVE
  To study the relationship between aromatase expression in endometriotic tissues and clinical and laboratory findings.
  
  
  METHODS
  Prospective basic and clinical research.
  
  
  METHODS
  University hospital.
  
  
  METHODS
  Sixty-two women with endometriosis, and 12 without endometriosis.
  
  
  METHODS
  Conservative surgery, or hysterectomy and adnexectomy, along with an immunohistochemical study of aromatase in endometriotic and nonendometriotic tissues.
  
  
  METHODS
  Symptoms of the disease, ultrasound and surgical findings, values of tumor markers, steroids and immunoglobulins, and recurrences after surgery.
  
  
  RESULTS
  We observed positive immunohistochemical expression for aromatase in endometriotic tissues from 38 patients (61.3%). Aromatase expression was negative in the rest of the tissues studied and in the 12 cases without endometriosis. Aromatase-positive patients had a higher number of endometriomas, more bilaterality, and more moderate-to-severe chronic pelvic pain. Also, infertility and associated leiomyomas were more frequent in these patients, though without significant differences. There were no differences in recurrence of the disease 1 year later. Estradiol and PRL levels were significantly higher, and IgG values lower, than in aromatase-negative patients. High values of blood sedimentation rate were more frequent in aromatase-negative patients.
  
  
  CONCLUSIONS
  Molecular alterations such as the presence of aromatase in endometriotic tissues could be involved in the development or maintenance of endometriosis. Our findings suggest major severity, activity, and chronic pelvic pain in patients with aromatase in endometriotic tissue.
authors.affiliation: Service of Obstetrics and Gynecology, San Juan University Hospital, Alicante, Spain. acien@umh.es
authors.forename: Pedro
authors.initials: P
authors.lastname: Acién
authors.forename: Irene
authors.initials: I
authors.lastname: Velasco
authors.forename: Mercedes
authors.initials: M
authors.lastname: Gutiérrez
authors.forename: Monserrat
authors.initials: M
authors.lastname: Martínez-Beltrán
mesh_terms: D000328:Adult; D001141:Aromatase / Q000096:biosynthesis* / Q000737:chemistry / Q000235:genetics*; D004715:Endometriosis / Q000201:enzymology* / Q000209:etiology / Q000601:surgery; D004717:Endometrium / Q000201:enzymology* / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D015971:Gene Expression Regulation, Enzymologic / Q000502:physiology*; D006801:Humans; D011446:Prospective Studies
chemical_list: D001141:Aromatase