title: High-speed, high-resolution optical coherence tomography retinal imaging with a frequency-swept laser at 850 nm.
abstract: High-speed, high-resolution optical coherence tomography (OCT) imaging of the human retina is demonstrated using a frequency-swept laser at 850 nm. A compact external cavity semiconductor laser design, optimized for swept-source ophthalmic OCT, is described. The laser enables an effective 16 kHz sweep rate with >10 mm coherence length and a tuning range of approximately 35 nm full width at half-maximum, yielding an axial resolution of <7 micro m in tissue.
authors.affiliation: Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. vjsriniv@mit.edu
authors.forename: V J
authors.initials: VJ
authors.lastname: Srinivasan
authors.forename: R
authors.initials: R
authors.lastname: Huber
authors.forename: I
authors.initials: I
authors.lastname: Gorczynska
authors.forename: J G
authors.initials: JG
authors.lastname: Fujimoto
authors.forename: J Y
authors.initials: JY
authors.lastname: Jiang
authors.forename: P
authors.initials: P
authors.lastname: Reisen
authors.forename: A E
authors.initials: AE
authors.lastname: Cable
mesh_terms: D004867:Equipment Design; D019544:Equipment Failure Analysis; D006801:Humans; D007089:Image Enhancement / Q000295:instrumentation* / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000295:instrumentation* / Q000379:methods; D007834:Lasers; D015203:Reproducibility of Results; D012160:Retina / Q000166:cytology*; D042261:Retinoscopes; D012680:Sensitivity and Specificity; D041623:Tomography, Optical Coherence / Q000295:instrumentation* / Q000379:methods