title: Emblica officinalis (Linn.) fruit extract provides protection against radiation-induced hematological and biochemical alterations in mice.
abstract: Oral administration of Emblica officinalis (Linn.) before exposure to gamma radiation was found to be effective in protecting mice against the hematological and biochemical modulation in peripheral blood. A significant increase in the RBC, WBC, hemoglobin, and hematocrit values was observed in the animals pretreated with E. officinalis extract as compared to the hematological values observed in the irradiated group. Furthermore, radiation sickness was greatly inhibited in those mice that were irradiated with prior treatment of E. officinalis. A significant decrease in glutathione (GSH) content and increase in lipid peroxidation (LPx) level were also observed in irradiated animals; whereas E. officinalis pretreated irradiated animals exhibited a significant increase in GSH content and decrease in LPx level, but such remained below the normal. The results from the present study suggest that E. officinalis pretreatment provides protection against irradiation to Swiss albino mice.
authors.affiliation: Radiation and Cancer Biology Laboratory, Department of Zoology, University of Rajasthan, Jaipur, India.
authors.forename: Inder
authors.initials: I
authors.lastname: Singh
authors.forename: Dhanraj
authors.initials: D
authors.lastname: Soyal
authors.forename: Pradeep Kumar
authors.initials: PK
authors.lastname: Goyal
mesh_terms: D000818:Animals; D004307:Dose-Response Relationship, Radiation; D004906:Erythrocyte Count; D005638:Fruit / Q000737:chemistry*; D005978:Glutathione / Q000097:blood; D006400:Hematocrit; D006454:Hemoglobins / Q000378:metabolism; D007958:Leukocyte Count; D015227:Lipid Peroxidation / Q000187:drug effects / Q000528:radiation effects; D051379:Mice; D029842:Phyllanthus emblica / Q000737:chemistry*; D010936:Plant Extracts / Q000494:pharmacology* / Q000627:therapeutic use; D011833:Radiation Injuries, Experimental / Q000517:prevention & control*; D011837:Radiation-Protective Agents / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D006454:Hemoglobins; D010936:Plant Extracts; D011837:Radiation-Protective Agents; D005978:Glutathione