title: Association of common polymorphisms in inflammatory genes with risk of developing cancers of the upper aerodigestive tract.
abstract: OBJECTIVE
  The purpose of this study was to investigate the role of polymorphisms of genes involved in inflammation in the risk of cancers of the upper aerodigestive tract (UADT).
  
  
  METHODS
  We have evaluated the role of polymorphisms in key genes related to inflammation, namely IL1B (rs1143627), COX2/PTGS2 (rs5275), and IL8 (rs4073) in a large case-control study comprising 811 UADT cancer cases and 1,083 controls.
  
  
  RESULTS
  An association was observed for squamous cell carcinoma of the pharynx for a polymorphism in the promoter of the IL1B gene, with an OR of 2.39 (95% CI = 1.19-4.81) for the homozygotes for the minor allele A promoter polymorphism of IL8 was associated with decreased risk of laryngeal cancer, with an OR of 0.70 (95% CI = 0.50-0.98) for carriers of the minor allele.
  
  
  CONCLUSIONS
  To our knowledge, this is the first report on the role of these polymorphisms with respect to UADT carcinogenesis. Our results suggest that inflammation-related polymorphisms play a role, albeit minor, in the risk of developing cancers of the upper aerodigestive tract.
authors.affiliation: International Agency for Research on Cancer, 150 Cours Albert Thomas, 69372 Lyon, France.
authors.forename: Daniele
authors.initials: D
authors.lastname: Campa
authors.forename: Mia
authors.initials: M
authors.lastname: Hashibe
authors.forename: David
authors.initials: D
authors.lastname: Zaridze
authors.forename: Neonila
authors.initials: N
authors.lastname: Szeszenia-Dabrowska
authors.forename: Ioan Nicolae
authors.initials: IN
authors.lastname: Mates
authors.forename: Vladimir
authors.initials: V
authors.lastname: Janout
authors.forename: Ivana
authors.initials: I
authors.lastname: Holcatova
authors.forename: Eleonóra
authors.initials: E
authors.lastname: Fabiánová
authors.forename: Valérie
authors.initials: V
authors.lastname: Gaborieau
authors.forename: Rayjean J
authors.initials: RJ
authors.lastname: Hung
authors.forename: Paolo
authors.initials: P
authors.lastname: Boffetta
authors.forename: Paul
authors.initials: P
authors.lastname: Brennan
authors.forename: Federico
authors.initials: F
authors.lastname: Canzian
mesh_terms: D016022:Case-Control Studies; D005061:Europe, Eastern / Q000453:epidemiology; D006801:Humans; D007249:Inflammation / Q000453:epidemiology / Q000235:genetics*; D053583:Interleukin-1beta / Q000235:genetics*; D007822:Laryngeal Neoplasms / Q000453:epidemiology / Q000235:genetics*; D009062:Mouth Neoplasms / Q000453:epidemiology / Q000235:genetics*; D010610:Pharyngeal Neoplasms / Q000453:epidemiology / Q000235:genetics*; D011110:Polymorphism, Genetic; D018570:Risk Assessment; D012307:Risk Factors
chemical_list: C508585:IL1B protein, human; D053583:Interleukin-1beta