title: Ultrasound monitoring of tissue ablation via deformation model and shape priors.
abstract: A rapid approach to monitor ablative therapy through optimizing shape and elasticity parameters is introduced. Our motivating clinical application is targeting and intraoperative monitoring of hepatic tumor thermal ablation, but the method translates to the generic problem of encapsulated stiff masses (solid organs, tumors, ablated lesions, etc.) in ultrasound imaging. The approach involves the integration of the following components: a biomechanical computational model of the tissue, a correlation approach to estimate/track tissue deformation, and an optimization method to solve the inverse problem and recover the shape parameters in the volume of interest. Successful convergence and reliability studies were conducted on simulated data. Then ex-vivo studies were performed on 18 ex-vivo bovine liver samples previously ablated under ultrasound monitoring in controlled laboratory environment. While B-mode ultrasound does not clearly identify the development of necrotic lesions, the proposed technique can potentially segment the ablation zone. The same framework can also yield both partial and full elasticity reconstruction.
authors.affiliation: Engineering Research Center, Johns Hopkins University, Baltimore, MD, USA. eboctor@ieee.org
authors.forename: Emad
authors.initials: E
authors.lastname: Boctor
authors.forename: Michelle
authors.initials: M
authors.lastname: deOliveira
authors.forename: Michael
authors.initials: M
authors.lastname: Choti
authors.forename: Roger
authors.initials: R
authors.lastname: Ghanem
authors.forename: Russell
authors.initials: R
authors.lastname: Taylor
authors.forename: Gregory
authors.initials: G
authors.lastname: Hager
authors.forename: Gabor
authors.initials: G
authors.lastname: Fichtinger
mesh_terms: D000465:Algorithms; D000818:Animals; D002417:Cattle; D004548:Elasticity; D006498:Hepatectomy / Q000379:methods*; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods; D066298:In Vitro Techniques; D008099:Liver / Q000000981:diagnostic imaging* / Q000502:physiology / Q000601:surgery*; D008954:Models, Biological; D015233:Models, Statistical; D010363:Pattern Recognition, Automated / Q000379:methods; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013314:Stress, Mechanical; D013382:Subtraction Technique; D025321:Surgery, Computer-Assisted / Q000379:methods*; D018084:Ultrasonography, Interventional / Q000379:methods