title: [Clinical early intervention of Tongxia Huayu Decoction on pancreatic microcirculatory disturbance in severe acute pancreatitis].
abstract: OBJECTIVE
  To study the mechanisms of Tongxia Huayu Decoction (a Chinese herbal decoction for purgation and removing blood stasis) in prognostic improvement for severe acute pancreatitis by early intervention on pancreatic microcirculatory disturbance.
  
  
  METHODS
  Fifty-three patients with severe acute pancreatitis were divided randomly into treatment group (n=28) and control group (n=25). Tongxia Huayu Decoction was given to the patients in treatment group in addition to the normal treatment in control group for one week. The clinical symptoms and signs, hemodiastase, urinary amylase, C-reactive protein (CRP) and endothelin (ET) of the patients in the two groups before and after treatment were observed and detected.
  
  
  RESULTS
  The total response rate of the treatment group was 98.4%, while that of the control group was 80%, with significant difference between them (P<0.05). There was no significant difference of the contents of hemodiastase, urinary amylase, CRP and ET between the two groups before treatment, while they were significantly decreased after treatment (P<0.01) with more obvious change in treatment group (P<0.01).
  
  
  CONCLUSIONS
  Tongxia Huayu Decoction brings satisfied therapeutic effect on severe acute pancreatitis. The mechanisms may associate with its reducing function on ET releasing so as to inhibit the pancreatic microcirculatory disturbance and acinar cell injury induced by ET.
authors.affiliation: Emergency Department, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China.
authors.forename: Bang-jiang
authors.initials: BJ
authors.lastname: Fang
authors.forename: Pei-yang
authors.initials: PY
authors.lastname: Gao
authors.forename: Song-hua
authors.initials: SH
authors.lastname: He
authors.forename: Hao
authors.initials: H
authors.lastname: Chen
authors.forename: Ping
authors.initials: P
authors.lastname: Shen
authors.forename: Yi-ying
authors.initials: YY
authors.lastname: Zhang
authors.forename: Jing-zhe
authors.initials: JZ
authors.lastname: Zhang
mesh_terms: D000328:Adult; D002097:C-Reactive Protein / Q000378:metabolism; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D016232:Endothelins / Q000097:blood; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008833:Microcirculation / Q000187:drug effects; D008875:Middle Aged; D010179:Pancreas / Q000098:blood supply / Q000187:drug effects* / Q000473:pathology; D019283:Pancreatitis, Acute Necrotizing / Q000188:drug therapy* / Q000503:physiopathology; D008517:Phytotherapy; D016896:Treatment Outcome
chemical_list: D004365:Drugs, Chinese Herbal; D016232:Endothelins; C527185:tongxia huayu; D002097:C-Reactive Protein