[Protective effects of minocycline against apoptosis of olfactory sensory neurons].
OBJECTIVE
To investigate the protective effects of minocycline against apoptosis of olfactory sensory neurons induced by sinusitis.


METHODS
Sixty adult SD rats were divided randomly into three groups: control group (group A), sinusitis group (group B) and intravenous injection of minocycline group (group C). The rats were sacrificed at 1,3,5 d and 7 d after surgery, and then the tissue sections of olfactory epithelium were stained and evaluated with hematoxylin and eosin (HE) and immunohistochemistry method.


RESULTS
The histopathological changes in maxillary sinus epithelium tissues observed with he staining microscopic examination in group B and C were worse than that in group A. Significant difference of the thickness of olfactory epithelium and Caspase-3 activity was demonstrated in group B and group C.


CONCLUSIONS
The result demonstrated that minocycline could inhibit expression of Caspase-3 in rats with sinusitis.
Ye
Fanglei
F
Department of Otorhinolaryngology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou,450052, China. yefanglei@hotmail.com
Guo
Xiangdong
X
Lou
Weihua
W
Xie
Tianfei
T
D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D053148:Caspase 3 / Q000378:metabolism; D008911:Minocycline / Q000494:pharmacology*; D009831:Olfactory Mucosa / Q000187:drug effects / Q000473:pathology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D011984:Sensory Receptor Cells / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D012852:Sinusitis / Q000503:physiopathology
C505410:Casp3 protein, rat; D053148:Caspase 3; D008911:Minocycline