title: Anatomically constrained deformation for design of cranial implant: methodology and validation.
abstract: We present a new approach for cranial implant design which uses anatomical constrained deformation based on reference models. The methodological framework contains three steps: patient-specific generation of the reference model containing the anatomical constraints about the skull shape; determination of the spatial correspondence between the patient skull and the reference model by 3D matching; adaptive deformation of the fragment on the reference model corresponding to the defect area on the patient skull for implant design. The proposed method was validated by simulating the reconstruction of artificially generated defects on healthy skulls. The validation results show that this approach can generate implant geometry very fast and with satisfactory quality. This approach also outperforms the surface interpolation method in reconstructing cranial defects.
authors.affiliation: Helmholtz Institute for Biomedical Engineering, RWTH Aachen University, Aachen, Germany. twu@hia.rwth-aachen.de
authors.forename: Ting
authors.initials: T
authors.lastname: Wu
authors.forename: Martin
authors.initials: M
authors.lastname: Engelhardt
authors.forename: Lorenz
authors.initials: L
authors.lastname: Fieten
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Popovic
authors.forename: Klaus
authors.initials: K
authors.lastname: Radermacher
mesh_terms: D000328:Adult; D000465:Algorithms; D003399:Craniotomy / Q000295:instrumentation* / Q000379:methods; D019544:Equipment Failure Analysis / Q000379:methods; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011474:Prosthesis Design / Q000379:methods*; D017755:Prosthesis Fitting / Q000379:methods*; D011856:Radiographic Image Enhancement / Q000379:methods; D011857:Radiographic Image Interpretation, Computer-Assisted / Q000379:methods*; D019651:Plastic Surgery Procedures / Q000295:instrumentation / Q000379:methods; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012886:Skull / Q000000981:diagnostic imaging* / Q000601:surgery*