title: [Diterpenes and other components of Croton hirtus (Euphorbiaceae)].
abstract: The roots of Croton hirtus (Euphorbiaceae) collected in Paraiso, Cartago (Costa Rica) afforded, in addition to the few known metabolites, 20 new compounds: the bis-nor dolabradane 1, the dolabradanes 2 and 3, the kauranes 4-7, the cyclopropakauranes 8 and 9, the hirtusanes 10-15, the germacradiene esters 16-18 and the C-25 compound 21, presumably formed by a Diels-Alder reaction between compound 18 and a monoterpene. All structures were elucidated using high field 1D and 2D NMR techniques. MS fragmentation patterns are here reported. The absolute configurations of 4 and 9 were elucidated by using circular dichroism. The separation was performed with modern chromatographic technics.
authors.affiliation: Escuela de Química y Centro de Investigación de Productos Naturales, Universidad de Costa Rica, San José, Costa Rica. renato@calzada.equi.ucr.ac.cr
authors.forename: J C
authors.initials: JC
authors.lastname: Fuentes
authors.forename: V
authors.initials: V
authors.lastname: Castro
authors.forename: J
authors.initials: J
authors.lastname: Jakupovic
authors.forename: R
authors.initials: R
authors.lastname: Murillo
mesh_terms: D002851:Chromatography, High Pressure Liquid; D029802:Croton / Q000737:chemistry*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification*; D010936:Plant Extracts / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry*
chemical_list: D004224:Diterpenes; D010936:Plant Extracts