title: Theoretical investigation of measuring cerebral blood flow in the adult human head using bolus Indocyanine Green injection and near-infrared spectroscopy.
abstract: To investigate the accuracy of measuring cerebral blood flow (CBF) using a bolus injection of Indocyanine Green (ICG) detected by near-infrared spectroscopy in adult human heads, simulations were performed using a two-layered model representing the extracerebral and intracerebral layers. Modeled optical data were converted into tissue ICG concentration using either the one-detector modified Beer-Lambert law (MBLL) method, or the two-detector partial path-length (PPL) method. The CBFs were estimated using deconvolution and blood flow index techniques. Using the MBLL method, the CBFs were significantly underestimated but the PPL method improved their accuracy and robustness, especially when used as relative measures. The dispersion of the arterial input function also affected the CBF estimates.
authors.affiliation: Department of Medical Physics, University College London, London, UK. tsl@medphys.ucl.ac.uk
authors.forename: Terence S
authors.initials: TS
authors.lastname: Leung
authors.forename: Ilias
authors.initials: I
authors.lastname: Tachtsidis
authors.forename: Martin
authors.initials: M
authors.lastname: Tisdall
authors.forename: Martin
authors.initials: M
authors.lastname: Smith
authors.forename: David T
authors.initials: DT
authors.lastname: Delpy
authors.forename: Clare E
authors.initials: CE
authors.lastname: Elwell
mesh_terms: D000465:Algorithms; D002560:Cerebrovascular Circulation / Q000502:physiology*; D003198:Computer Simulation; D003936:Diagnosis, Computer-Assisted / Q000379:methods*; D006801:Humans; D007208:Indocyanine Green; D008955:Models, Cardiovascular; D008959:Models, Neurological; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013055:Spectrophotometry, Infrared / Q000379:methods*
chemical_list: D007208:Indocyanine Green