title: Anti-MAG/SGPG associated neuropathy does not commonly cause distal nerve temporal dispersion.
abstract: Patients with anti-myelin associated glycoprotein (anti-MAG) neuropathy have uniform slowing without temporal dispersion, but do usually have disproportionately distal slowing. We evaluated distal compound muscle action potential (CMAP) dispersion in 29 patients with anti-MAG/sulphated glucuronyl paragloboside (SGPG) neuropathy (titres > or = 12,800). Among 138 motor responses, 15% (tibial), 7.3% (peroneal), 10.7% (median) and 13.8% (ulnar) had distal CMAP duration > 9 ms. Disproportionate distal slowing with normal distal CMAP duration in the arms may be useful to differentiate chronic inflammatory demyelinating polyneuropathy from anti-MAG/SGPG associated neuropathy.
authors.affiliation: Department of Neurology, Weill Medical College of Cornell University, New York, NY, USA.
authors.forename: F A A
authors.initials: FA
authors.lastname: Gondim
authors.forename: E A
authors.initials: EA
authors.lastname: De Sousa
authors.forename: N
authors.initials: N
authors.lastname: Latov
authors.forename: H W
authors.initials: HW
authors.lastname: Sander
authors.forename: R L
authors.initials: RL
authors.lastname: Chin
authors.forename: T H
authors.initials: TH
authors.lastname: Brannagan
mesh_terms: D000200:Action Potentials; D000906:Antibodies; D001132:Arm / Q000502:physiology; D004594:Electrophysiology; D005260:Female; D005915:Globosides / Q000276:immunology; D006801:Humans; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000503:physiopathology*; D018992:Myelin-Associated Glycoprotein / Q000276:immunology*; D011115:Polyneuropathies / Q000276:immunology / Q000503:physiopathology*; D012189:Retrospective Studies
chemical_list: D000906:Antibodies; D005915:Globosides; D018992:Myelin-Associated Glycoprotein; C051917:sulfate-3-glucuronyl paragloboside