title: The impact of murine strain and sex on postnatal development after maternal dietary restriction during pregnancy.
abstract: The objective of this study was to characterize offspring responses to maternal dietary restriction (DR) in two phylogenetically distant strains of mice: A/J and C57BL/6J (B6). Pregnant mice were fed 100% or 70% of ad libitum between 6.5 and 17.5 days (d) gestation. Offspring were fed 100% ad libitum postweaning. All comparisons were made to strain and sex matched controls. Male DR-B6 offspring initially grew slower than controls; however, by 77 d and 182 d they were significantly heavier (P<0.05). Further, they had an increase percentage fat mass (+70%, P<0.01) by 182 d and were glucose intolerant at both 80 d (P<0.001) and 186 d (P<0.05). In contrast, weight, %Fat mass and glucose tolerance in DR-A/J males during postnatal life were not different from controls. Female DR-B6 mice showed catch-up growth during the first 77 d of life; however, their weight, %Fat mass and glucose tolerance were not different from controls at 80 d and 186 d. Although female DR-A/J were heavier than controls at 182 d (P<0.05), their %Fat mass and glucose tolerance were not different from controls at 182 d and 186 d. The observed strain and sex differences offer a unique opportunity to begin to define gene-environment interactions that contribute to developmental origins of health and disease.
authors.affiliation: Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada.
authors.forename: Brian S
authors.initials: BS
authors.lastname: Knight
authors.forename: Craig E
authors.initials: CE
authors.lastname: Pennell
authors.forename: S Lee
authors.initials: SL
authors.lastname: Adamson
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Lye
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000235:genetics; D001823:Body Composition / Q000235:genetics; D001835:Body Weight / Q000235:genetics; D047108:Embryonic Development / Q000235:genetics*; D005260:Female; D005508:Food Deprivation; D005838:Genotype; D018149:Glucose Intolerance / Q000235:genetics* / Q000503:physiopathology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D023421:Models, Animal; D009765:Obesity / Q000235:genetics* / Q000503:physiopathology; D010641:Phenotype; D011247:Pregnancy; D039401:Prenatal Nutritional Physiological Phenomena; D012737:Sex Factors; D013045:Species Specificity; D013997:Time Factors
chemical_list: D001786:Blood Glucose