title: Triterpene saponins from Bacopa monnieri and their antidepressant effects in two mice models.
abstract: Three new triterpene glycosides, bacopasides VI-VIII (1-3), together with three known analogues, bacopaside I (4), bacopaside II (5), and bacopasaponsin C (6), were isolated from the whole plant of Bacopa monnieri. Compounds 4, 5, and 6 showed antidepressant activity when tested on forced swimming and tail suspension in mice, respectively.
authors.affiliation: Department of Phytochemistry, College of Pharmacy, Second Military Medical University, Shanghai 200433, People's Republic of China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Zhou
authors.forename: Yun-Heng
authors.initials: YH
authors.lastname: Shen
authors.forename: Chuan
authors.initials: C
authors.lastname: Zhang
authors.forename: Juan
authors.initials: J
authors.lastname: Su
authors.forename: Run-Hui
authors.initials: RH
authors.lastname: Liu
authors.forename: Wei-Dong
authors.initials: WD
authors.lastname: Zhang
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D034681:Bacopa / Q000737:chemistry*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D051379:Mice; D023421:Models, Animal; D010946:Plants, Medicinal / Q000737:chemistry*; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000928:Antidepressive Agents; D004365:Drugs, Chinese Herbal; D012503:Saponins; D014315:Triterpenes; C519753:bacopaside VI; C519754:bacopaside VII; C519755:bacopaside VIII