TORC1 is a calcium- and cAMP-sensitive coincidence detector involved in hippocampal long-term synaptic plasticity.
A key feature of memory processes is to link different input signals by association and to preserve this coupling at the level of synaptic connections. Late-phase long-term potentiation (L-LTP), a form of synaptic plasticity thought to encode long-term memory, requires gene transcription and protein synthesis. In this study, we report that a recently cloned coactivator of cAMP-response element-binding protein (CREB), called transducer of regulated CREB activity 1 (TORC1), contributes to this process by sensing the coincidence of calcium and cAMP signals in neurons and by converting it into a transcriptional response that leads to the synthesis of factors required for enhanced synaptic transmission. We provide evidence that TORC1 is involved in L-LTP maintenance at the Schaffer collateral-CA1 synapses in the hippocampus.
Kovács
Krisztián A
KA
Center for Psychiatric Neuroscience and Service of Child and Adolescent Psychiatry, Department of Psychiatry, University Medical Center, University of Lausanne, CH-1008 Prilly-Lausanne, Switzerland.
Steullet
Pascal
P
Steinmann
Myriam
M
Do
Kim Q
KQ
Magistretti
Pierre J
PJ
Halfon
Olivier
O
Cardinaux
Jean-René
JR
D021581:Active Transport, Cell Nucleus; D000818:Animals; D019703:Calcineurin / Q000378:metabolism; D000242:Cyclic AMP / Q000378:metabolism*; D017362:Cyclic AMP Response Element-Binding Protein / Q000378:metabolism; D006624:Hippocampus / Q000378:metabolism*; D017774:Long-Term Potentiation; D008297:Male; D051379:Mice; D009474:Neurons / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D013569:Synapses; D015534:Trans-Activators / Q000502:physiology; D014157:Transcription Factors / Q000378:metabolism* / Q000502:physiology
C545700:CRTC2 protein, rat; C519509:Crtc1 protein, mouse; C519510:Crtc1 protein, rat; C504923:Crtc2 protein, mouse; D017362:Cyclic AMP Response Element-Binding Protein; D012333:RNA, Messenger; D015534:Trans-Activators; D014157:Transcription Factors; D000242:Cyclic AMP; D019703:Calcineurin