title: A flow reactor process for the synthesis of peptides utilizing immobilized reagents, scavengers and catch and release protocols.
abstract: A general flow process for the multi-step assembly of peptides has been developed and this procedure has been used to successfully construct a series of Boc, Cbz and Fmoc N-protected dipeptides in excellent yields and purities, including an extension of the method to enable the preparation of a tripeptide derivative.
authors.affiliation: Innovative Technology Centre, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK CB2 1EW.
authors.forename: Ian R
authors.initials: IR
authors.lastname: Baxendale
authors.forename: Steven V
authors.initials: SV
authors.lastname: Ley
authors.forename: Christopher D
authors.initials: CD
authors.lastname: Smith
authors.forename: Geoffrey K
authors.initials: GK
authors.lastname: Tranmer
mesh_terms: D000596:Amino Acids / Q000737:chemistry; D007202:Indicators and Reagents; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation* / Q000379:methods*; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D000596:Amino Acids; D007202:Indicators and Reagents; D010455:Peptides