title: Free radical trapping properties of several ethyl-substituted derivatives of 5-ethoxycarbonyl-5-methyl-1-pyrroline N-oxide (EMPO).
abstract: The spin trapping behavior of several ethyl-substituted EMPO derivatives, cis- and trans-5-ethoxycarbonyl-3-ethyl-5-methyl-pyrroline N-oxide (3,5-EEMPO), 5-ethoxycarbonyl-4-ethyl-5-methyl-pyrroline N-oxide (4,5-EEMPO), cis- and trans-5-ethoxycarbonyl-5-ethyl-3-methyl-pyrroline N-oxide (5,3-EEMPO), and 5-ethoxycarbonyl-5-ethyl-4-methyl-pyrroline N-oxide (5,4-EEMPO), toward a series of different oxygen- and carbon-centered radicals, is described. Considerably different stabilities of the superoxide adducts (ranging from about 12 to 55 min) as well as the formation of other radical adducts were observed.
authors.affiliation: Molecular Pharmacology and Toxicology Unit, Department of Natural Science, University of Veterinary Medicine Vienna, Veterinärplatz 1, A-1210 Vienna, Austria. Klaus.Stolze@vu-wien.ac.at
authors.forename: Klaus
authors.initials: K
authors.lastname: Stolze
authors.forename: Natascha
authors.initials: N
authors.lastname: Rohr-Udilova
authors.forename: Thomas
authors.initials: T
authors.lastname: Rosenau
authors.forename: Andreas
authors.initials: A
authors.lastname: Hofinger
authors.forename: Hans
authors.initials: H
authors.lastname: Nohl
mesh_terms: D002384:Catalysis; D003497:Cyclic N-Oxides / Q000138:chemical synthesis* / Q000494:pharmacology*; D004578:Electron Spin Resonance Spectroscopy; D016166:Free Radical Scavengers / Q000138:chemical synthesis* / Q000494:pharmacology*; D006207:Half-Life; D017665:Hydroxyl Radical / Q000737:chemistry; D007202:Indicators and Reagents; D007501:Iron; D008054:Lipid Peroxides / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D000432:Methanol / Q000737:chemistry; D021241:Spectrometry, Mass, Electrospray Ionization; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared; D019097:Spin Trapping; D013481:Superoxides / Q000737:chemistry
chemical_list: C408629:5-ethoxycarbonyl-5-methyl-1-pyrroline N-oxide; D003497:Cyclic N-Oxides; D016166:Free Radical Scavengers; D007202:Indicators and Reagents; D008054:Lipid Peroxides; D013481:Superoxides; D017665:Hydroxyl Radical; D007501:Iron; D000432:Methanol