Effect of head-down hanging on the course of degenerative process in the hind paw muscles of 12-month-old MDX mice.
Effect of functional unloading on the course of degenerative process in muscles was studied in dystrophin-deficient mdx mice. Head down-hanging of animals led to a significant decrease in the cross-section area of muscle fibers, increase in the percentage of fibers with centrally located nuclei and of Evans blue-stained fibers. Gravitation unloading of 12-month-old animals with pronounced manifestations of muscular dystrophy did not inhibit this pathological process.
Tarakin
P P
PP
Institute of Biomedical Problems, Russian Academy of Sciences, Moscow. tarakin_pavel@mail.ru
Gasnikova
N M
NM
Shenkman
B S
BS
D000818:Animals; D001837:Body Weights and Measures; D005070:Evans Blue; D019417:Hindlimb Suspension / Q000502:physiology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018101:Mice, Inbred mdx; D009119:Muscle Contraction / Q000502:physiology*; D018482:Muscle, Skeletal / Q000166:cytology* / Q000502:physiology*; D009137:Muscular Dystrophy, Animal / Q000473:pathology*
D005070:Evans Blue