Expedient synthesis of substituted (diphenylphosphinoylmethyl)benzenes.
An efficient protocol for the synthesis of structurally diverse (diphenylphosphinoylmethyl)benzenes is described. The reaction employs readily available carboxylic acids, chlorodiphenylphosphine, and water as the reagents. A 97% reduction in the reaction times and substantially higher yields of products result, up to a 60% increase, if the reactions are performed under microwave irradiation. The first examples of transition-metal-catalyzed reactions applied to 4-bromo-1,3-bis(diphenylphosphinoylmethyl)benzene are also reported.
Bew
Sean P
SP
School of Chemical Sciences & Pharmacy, University of East Anglia, Norwich, NR4 7TJ, UK. s.bew@uea.ac.uk
Brimage
Rebecca A
RA
Hughes
David L
DL
Legentil
Laurent
L
Sharma
Sunil V
SV
Wilson
Martin A
MA
D001555:Benzene Derivatives / Q000138:chemical synthesis / Q000737:chemistry*; D005030:Ethylenes / Q000737:chemistry*; D008872:Microwaves; D015394:Molecular Structure
D001555:Benzene Derivatives; D005030:Ethylenes; C036216:ethylene