Effect of a commercial extract of Paullinia cupana (guarana) on the binding of 99mTc-DMSA on blood constituents: An in vivo study.
We studied the influence of a commercial extract of Paullinia cupana (guarana) on the binding of technetium-99m-dimercaptosuccinic acid ((99m)Tc-DMSA) on blood constituents. Plasma (P) and blood cells (BC) from Wistar rats (control and treated) were separated. P and BC were precipitated with trichloroacetic acid (TCA) or ammonium sulphate (AS) and soluble (SF) and insoluble fractions (IF) isolated. The percentage of incorporated radioactivity (%ATI) in each fraction was determined. The treatment influenced the %ATI in IF-P and in IF-BC isolated by TCA precipitation.
Freitas
R S
RS
Departamento de Biofísica e Biometria, Instituto de Biologia Roberto Alcantara Gomes, Universidade do Estado do Rio de Janeiro, Avenida 28 de Setembro, 87 Fundos, 4 Andar, Rio de Janeiro 20551-030, Brazil.
Moreno
S R F
SR
Lima-Filho
G L
GL
Fonseca
A S
AS
Bernardo-Filho
M
M
D000818:Animals; D001773:Blood Cells / Q000187:drug effects / Q000378:metabolism*; D005260:Female; D066298:In Vitro Techniques; D032126:Paullinia / Q000737:chemistry*; D010936:Plant Extracts / Q000494:pharmacology*; D010949:Plasma / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D019783:Technetium Tc 99m Dimercaptosuccinic Acid / Q000378:metabolism*
D010936:Plant Extracts; D019783:Technetium Tc 99m Dimercaptosuccinic Acid