title: Preparation and properties of chitosan/calcium phosphate composites for bone repair.
abstract: Chitosan/calcium phosphate (CaP) composites composed of bioactive calcium phosphate and flexible chitosan were made by a simple mixing-and-heating method. Phase composition, morphology, and mechanical properties--including in-air and in vitro fatigue behavior - were evaluated. Experimental results showed that the chitosan matrix did not affect the crystalline phase of CaP. However, the content of CaP additive affected the three-point bending strength of the composites. A CaP/ chitosan ratio of 5% by mass to volume in the composite achieved the significantly highest bending strength of 45.7 MPa. Stability of chitosan/CaP hybrid composites was apparently affected by in vitro cyclic loading. Nonetheless, when applied a loading stress of 11.4 MPa, the sample containing the optimal 5 mass/vol% CaP lasted 40 minutes in in vitro fatigue test until failure occurred. It was thus concluded that hybrid biocomposites with initial high strength might be a potential implant candidate for bone defect repair.
authors.affiliation: Institute of Oral Materials Science, Chung-Shan Medical University, Taichung 402, Taiwan, Republic of China. sjding@csmu.edu.tw
authors.forename: Shinn-Jyh
authors.initials: SJ
authors.lastname: Ding
mesh_terms: D000704:Analysis of Variance; D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry; D001861:Bone Regeneration; D018786:Bone Substitutes; D002130:Calcium Phosphates / Q000138:chemical synthesis / Q000737:chemistry; D048271:Chitosan / Q000138:chemical synthesis / Q000737:chemistry; D008422:Materials Testing; D019563:Mechanics; D053761:Nanocomposites; D018583:Pliability; D018709:Statistics, Nonparametric; D014961:X-Ray Diffraction
chemical_list: D001672:Biocompatible Materials; D018786:Bone Substitutes; D002130:Calcium Phosphates; D048271:Chitosan