title: Paratesticular neuroblastoma: a case against metastatic disease?
abstract: Paratesticular lesions of neuroblastoma are in contrast to testicular infiltration extremely rare. Six cases were reported in literature. It is debated, whether localizations are either metastatic lesions or part of multicentric disease. We present a 9-month-old boy with stage 4 neuroblastoma, in which an unsuspected scrotal localization was already present at birth. This lesion had not grown, in contrast to the other sites. The case illustrates that neuroblastoma is a multicentric tumor, originating in the adrenal area and paratesticular sympathic remnants. The lesions differed in clinical behavior. It further illustrates that multicentric localizations exhibit different clinical behavior.
authors.affiliation: Department of Pediatric Oncology, Emma Children Hospital AMC, University of Amsterdam, Amsterdam, The Netherlands. h.vandenberg@amc.uva.nl
authors.forename: Henk
authors.initials: H
authors.lastname: van den Berg
authors.forename: Hubert N
authors.initials: HN
authors.lastname: Caron
mesh_terms: D019797:3-Iodobenzylguanidine / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003131:Combined Modality Therapy; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D008297:Male; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D009447:Neuroblastoma / Q000473:pathology / Q000556:secondary / Q000628:therapy; D033581:Stem Cell Transplantation; D013736:Testicular Neoplasms / Q000473:pathology / Q000628:therapy; D014182:Transplantation, Autologous; D016896:Treatment Outcome
chemical_list: D019797:3-Iodobenzylguanidine