Left ventricular myocardial performance index in closely-related relatives of patients with dilated cardiomyopathy.
In this study, the left ventricular dimensions, systolic function, and left ventricular myocardial performance index in the first-degree relatives of the children with dilated cardiomyopathy (n=19), 30.0+/-17.6 years to normal age- and sex-matched controls (n=25), 27.4+/-17.7 years. The percentage ratio of the measured left ventricular end-diastolic dimension to the predicted left ventricular end-diastolic dimension (109+/-9.6 vs 105+/-11.8), left ventricular shortening fraction (34.5+/-6.6 vs 37.2+/-7%), and left ventricular ejection fraction (63.2+/-9.2 vs 66.5+/-8.1%) were not significantly different in the first-degree relatives and controls, respectively. However, the left ventricular myocardial performance index was significantly greater in the first-degree relatives than in controls (0.40+/-0.11 vs 0.31+/-0.03, p=0.01). In conclusion, the left ventricular myocardial performance index may be useful in early detect familial dilated cardiomyopathy in asymptomatic first-degree relatives of children with dilated cardiomyopathy.
Khositseth
Anant
A
Ausayapao
Prapat
P
D000328:Adult; D002311:Cardiomyopathy, Dilated / Q000000981:diagnostic imaging / Q000235:genetics* / Q000503:physiopathology*; D004452:Echocardiography; D005190:Family; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D016277:Ventricular Function, Left / Q000502:physiology*