Effects of triethylene tetraamine on the G-quadruplex structure in the human c-myc promoter.
The increasing data show that a parallel G-quadruplex structure formed by the element of nuclease-hypersensitivity element III(1) (NHE III(1)) in the P1 promoter of c-myc functions as a transcriptional repressor. Triethylene tetraamine has exhibited interesting properties of stabilizing both inter- and intra-molecular G-quadruplex structures and telomerase-inhibitory potency. Here, we present evidences showing that triethylene tetraamine facilitates the formation of G-quadruplex structure by the NHE III(1) element, and inhibits the expression of c-myc in HeLa cells.
Yin
Fei
F
Research Center of Pharmaceutical Chemistry & Chemobiology, Chongqing Technology and Business University, Chongqing 400067, China.
Liu
Jianhui
J
Deng
Xiaohong
X
Wang
Jingyun
J
D004247:DNA / Q000187:drug effects*; D015536:Down-Regulation; D054856:G-Quadruplexes; D016259:Genes, myc; D006147:Guanine / Q000737:chemistry; D006367:HeLa Cells; D006801:Humans; D011401:Promoter Regions, Genetic / Q000187:drug effects*; D016271:Proto-Oncogene Proteins c-myc / Q000096:biosynthesis; D037941:Silencer Elements, Transcriptional / Q000502:physiology*; D014266:Trientine / Q000494:pharmacology*
D016271:Proto-Oncogene Proteins c-myc; D006147:Guanine; D004247:DNA; D014266:Trientine