Mechanisms of leukemogenesis induced by bovine leukemia virus: prospects for novel anti-retroviral therapies in human.
In 1871, the observation of yellowish nodules in the enlarged spleen of a cow was considered to be the first reported case of bovine leukemia. The etiological agent of this lymphoproliferative disease, bovine leukemia virus (BLV), belongs to the deltaretrovirus genus which also includes the related human T-lymphotropic virus type 1 (HTLV-1). This review summarizes current knowledge of this viral system, which is important as a model for leukemogenesis. Recently, the BLV model has also cast light onto novel prospects for therapies of HTLV induced diseases, for which no satisfactory treatment exists so far.
Gillet
Nicolas
N
Molecular and Cellular Biology, Faculté Universitaire des Sciences Agronomiques, Gembloux, Belgium. gillet.n@fsagx.ac.be
Florins
Arnaud
A
Boxus
Mathieu
M
Burteau
Catherine
C
Nigro
Annamaria
A
Vandermeers
Fabian
F
Balon
Hervé
H
Bouzar
Amel-Baya
AB
Defoiche
Julien
J
Burny
Arsène
A
Reichert
Michal
M
Kettmann
Richard
R
Willems
Luc
L
D000818:Animals; D044966:Anti-Retroviral Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001402:B-Lymphocytes / Q000473:pathology / Q000502:physiology / Q000821:virology; D002417:Cattle; D016207:Cytokines / Q000378:metabolism; D004195:Disease Models, Animal; D016583:Enzootic Bovine Leukosis / Q000188:drug therapy* / Q000503:physiopathology / Q000821:virology; D015368:Human T-lymphotropic virus 1 / Q000472:pathogenicity; D006801:Humans; D001909:Leukemia Virus, Bovine / Q000235:genetics / Q000378:metabolism / Q000472:pathogenicity*; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000188:drug therapy* / Q000503:physiopathology; D007963:Leukocytes, Mononuclear / Q000473:pathology / Q000502:physiology / Q000821:virology; D012756:Sheep; D012757:Sheep Diseases / Q000188:drug therapy* / Q000276:immunology / Q000503:physiopathology / Q000821:virology; D014764:Viral Proteins / Q000235:genetics / Q000378:metabolism
D044966:Anti-Retroviral Agents; D016207:Cytokines; D014764:Viral Proteins