title: [Weekly paclitaxel therapy is curative for patients with retroperitoneal liposarcoma].
abstract: In March 2004, we resected a giant retroperitoneal liposarcoma and the transverse colon, spleen and left kidney in a 58-year-old woman. In July, recurrence was detected in the right pelvis and left upper abdomen; therefore, we resected the tumor. In September 2004, computed tomography (CT) revealed multiple recurrences in the right lower abdomen, left upper abdomen, front of the left lobe of the liver, and at the back of the stomach. In October 2004, we started mesna, doxorubicin, ifosfamide, and dacarbazine therapy (MAID); however, after 1 course, the disease progressed, and the patient developed edema in the bilateral legs due to inferior vena cava (IVC) compression. In November 2004, we started weekly paclitaxel therapy (100 mg/m(2), once a week for 3 weeks followed by 1 drug-free week). CT revealed no change as a result of chemotherapy; however, IVC compression had improved, and leg edema had decreased. In August 2005, chemotherapy was stopped; therefore,the patient's condition worsened. She died in September 2005. We performed weekly paclitaxel therapy for the patient with recurrent liposarcoma. This improved her symptoms and quality of life (QOL). Therefore,we consider weekly paclitaxel therapy to be effective for liposarcoma treatment.
authors.affiliation: Dept. of Surgery, Kumamoto Rosai Hospital.
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Yoshida
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Inoue
authors.forename: Tomofumi
authors.initials: T
authors.lastname: Ohsako
authors.forename: Nobuhide
authors.initials: N
authors.lastname: Nagamoto
authors.forename: Eiji
authors.initials: E
authors.lastname: Tanaka
authors.forename: Shu
authors.initials: S
authors.lastname: Tsuruzoe
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000627:therapeutic use*; D003082:Colectomy; D003131:Combined Modality Therapy; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008080:Liposarcoma / Q000188:drug therapy* / Q000556:secondary / Q000601:surgery; D008875:Middle Aged; D009392:Nephrectomy; D017239:Paclitaxel / Q000627:therapeutic use*; D010386:Pelvic Neoplasms / Q000188:drug therapy / Q000556:secondary; D011788:Quality of Life; D012186:Retroperitoneal Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D013154:Spleen / Q000601:surgery
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D017239:Paclitaxel