title: Primary signet-ring cell carcinoma of the prostate.
abstract: We report on an uncommon case of primary prostatic signet-ring cell carcinoma (SRCC) in a 78-year-old man. His prostatic specific antigen (PSA) level at presentation was 9.8 ng/ml. Histologically the tumor had a signet-ring morphology. Detailed immunohistochemical studies confirmed the prostatic origin of this neoplasm. All mucin stains were negative. This aggressive tumor is a distinct variant of primary prostatic carcinoma which should be distinguished from artefactual vacuolation of the tumor and metastatic disease.
authors.affiliation: Department of Pathology, 3rd Hospital of Social Security Foundation, Athens, Greece.
authors.forename: T
authors.initials: T
authors.lastname: Klimis
authors.forename: A
authors.initials: A
authors.lastname: Margaritopoulou
authors.forename: P
authors.initials: P
authors.lastname: Vlahos
authors.forename: N
authors.initials: N
authors.lastname: Kokotas