Alternative drugs against Trichomonas vaginalis.
To investigate the effect of drugs other than metronidazole, 3 non-pregnant women infected with Trichomonas vaginalis were treated with doxycycline, 2 x 200 mg/day for 1 week. Another 3 women were treated with praziquantel, single dose, 40 mg/kg body weight. No therapeutic effect was detected for either drug. In vitro, oxytetracycline led to death of T. vaginalis at a concentration of 15 mg in 0.5 mL medium. Extract of Myrtus communis caused death of T. vaginalis at pH 4.65, but failed to do so at pH 6.00. Extract of Eucalyptus comaldensis (50 mg in 0.1 mL medium) at pH 5.35 caused death of T. vaginalis after 24 hours.
Mahdi
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NK
Department of Microbiology, University of Basra, Iraq. nadhammahdi@yahoo.com
Gany
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ZH
Sharief
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M
D000328:Adult; D000818:Animals; D000890:Anti-Infective Agents / Q000600:supply & distribution / Q000627:therapeutic use*; D000994:Antitrichomonal Agents / Q000627:therapeutic use; D004318:Doxycycline / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D004353:Drug Evaluation, Preclinical; D005052:Eucalyptus; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007493:Iraq; D008795:Metronidazole / Q000627:therapeutic use; D008875:Middle Aged; D031651:Myrtus; D010118:Oxytetracycline / Q000627:therapeutic use*; D008517:Phytotherapy / Q000379:methods*; D010936:Plant Extracts / Q000627:therapeutic use; D011223:Praziquantel / Q000627:therapeutic use*; D013997:Time Factors; D016896:Treatment Outcome; D014247:Trichomonas Vaginitis / Q000175:diagnosis / Q000188:drug therapy* / Q000469:parasitology; D014246:Trichomonas vaginalis / Q000187:drug effects
D000890:Anti-Infective Agents; D000994:Antitrichomonal Agents; D010936:Plant Extracts; D008795:Metronidazole; D011223:Praziquantel; D004318:Doxycycline; D010118:Oxytetracycline