[Effect of hemodialysis with Chinese herbs of supplementing qi and activating blood circulation on platelet membranous glycoprotein CD62P in patients with chronic renal failure].
OBJECTIVE
To explore the effects of dialysate contained Chinese herbs for replenishing qi and activating blood circulation on platelet membranous glycoprotein CD62P in patients with chronic renal failure (CRF) undergoing hemodialysis.


METHODS
Forty patients underwent maintaining hemodialysis were randomly assigned to two groups, the Western medicated group (WMG) and the Chinese herbs group (CHG). The content of CD62P in all patients was detected by ELISA before and after hemodialysis.


RESULTS
The levels of blood urea nitrogen, creatinine, potassium, hematocrit, platelet count and carbon dioxide combining power (CO2CP) as well as the expression of CD62P after treatment were significantly changed in both groups with significant difference as compared with those before treatment (both P < 0.05). And comparison between the two groups in expression of CD62P after treatment also showed significant difference (P < 0.05). But the improvement in TCM syndrome between the two groups was insignificantly different (P > 0.05).


CONCLUSIONS
Hemodialysis with dialysate containing Chinese herbs of replenishing qi and activating blood circulation can decrease the expression of platelet membranous glycoprotein CD62P, which may be associated with the mechanism of Chinese herbs in treating CRF.
Wei
Fang-Ning
FN
Department of Renal Diseases, Guangdong Provincial Hospital of TCM, Guangzhou. weifangning@tom.com
Yang
Ni-Zhi
NZ
Huang
Xian-Zhang
XZ
D000328:Adult; D001775:Blood Circulation; D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism; D003131:Combined Modality Therapy; D015314:Dialysis Solutions; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000627:therapeutic use; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D019007:P-Selectin / Q000097:blood*; D008517:Phytotherapy; D019413:Qi; D006435:Renal Dialysis / Q000379:methods*
D015314:Dialysis Solutions; D004365:Drugs, Chinese Herbal; D019007:P-Selectin