Significance of tissue anisotropy in optical tomography of the infant brain.
We study the effect of tissue anisotropy in optical tomography of neonates. A Monte Carlo method capable of modeling photon migration in an arbitrary 3D tissue model with spatially varying optical properties and tissue anisotropy is used for simulating measurements of neonates. Anatomical and diffusion tensor magnetic resonance imaging of neonates are used for creating the anatomical models. We find that tissue anisotropy affects the measured signal and the pattern of sensitivity in optical measurements.
Heiskala
Juha
J
BioMag Laboratory, Helsinki University Central Hospital, Helsinki, Finland. juha.heiskala@iki.fi
Neuvonen
Tuomas
T
Grant
P Ellen
PE
Nissilä
Ilkka
I
D000465:Algorithms; D016880:Anisotropy; D016477:Artifacts; D001921:Brain / Q000033:anatomy & histology*; D003198:Computer Simulation; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D007223:Infant; D007231:Infant, Newborn; D008959:Models, Neurological; D015233:Models, Statistical; D009010:Monte Carlo Method; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D041622:Tomography, Optical / Q000379:methods*