[Paroxysmal iatrogenic acne and the epidermal growth factor receptor inhibitors (EGFR)].
Paroxysmal drug-induced acne is a peculiar condition recognized for decades in dermatology. It can be induced by a variety of drugs. In recent years, the epidermal growth factor receptor inhibitors used in oncology have shown this type of adverse effects. The pathogenic mechanism is likely related to the EGF implication in the rupture of the microcomedo wall resulting in the perifollicular inflammatory reaction typical for acne. Other cutaneous adverse effects have been reported with anti-EGFR drugs including paronychia and xerosis. The dermatological treatments of these drug-induced disorders must be adequately targeted.
Piérard-Franchimont
C
C
CHU du Sart Tilman, Liège, Belgique.
Blaise
G
G
Paquet
P
P
Quatresooz
R
R
Rorive
A
A
Piérard
G E
GE
D000152:Acne Vulgaris / Q000139:chemically induced* / Q000188:drug therapy*; D000970:Antineoplastic Agents / Q000009:adverse effects*; D066246:ErbB Receptors / Q000037:antagonists & inhibitors*; D006634:Histamine H1 Antagonists / Q000627:therapeutic use; D006801:Humans; D007049:Iatrogenic Disease; D009369:Neoplasms / Q000188:drug therapy; D016896:Treatment Outcome
D000970:Antineoplastic Agents; D006634:Histamine H1 Antagonists; D066246:ErbB Receptors