title: Diffusion-weighted imaging of the spine with a non-carr-purcell-meiboom-gill single-shot fast spin-echo sequence: initial experience.
abstract: OBJECTIVE
  To prospectively evaluate the signal-to-noise ratio (SNR) improvement in diffusion-weighted imaging (DWI) of the spine with the use of a newly developed non-Carr-Purcell-Meiboom-Gill (non-CPMG) single-shot fast spin-echo (SS-FSE) sequence and its effect on apparent diffusion coefficient (ADC) measurements.
  
  
  METHODS
  Twenty-four patients were enrolled after written informed consent. DWI of the spine was obtained with an echo-planar imaging (EPI)-based sequence followed by a non-CPMG SS-FSE technique. SNR and ADC values were measured over a lesion-free vertebral corpus. A quality score was assigned for each set of images to assess the image quality. When a spinal lesion was present, contrast-to-noise ratio (CNR) and ADC were also measured. Student t tests were used for statistical analysis.
  
  
  RESULTS
  Mean SNR values were 5.83 +/- 2.2 and 11.68 +/- 2.87 for EPI and non-CPMG SS-FSE DWI, respectively. SNR values measured in DWI using parallel imaging were found to be significantly higher (P < .01). Mean ADCs of the spine were 0.53 +/- 0.15 and 0.35 +/- 0.15 x 10(-3) mm(2)/s for EPI and non-CPMG SS-FSE DWI, respectively. Quality scores were found to be higher for the non-CPMG SS-FSE DWI technique (P < .05). Overall lesion CNR was found to be higher in DWI with non-CPMG SS-FSE.
  
  
  CONCLUSIONS
  The non-CPMG SS-FSE technique provides a significant improvement to current EPI-based DWI of the spine. A study including a larger number of patients is required to determine the use of this DWI sequence as a supplementary tool to conventional MR imaging for increasing diagnostic confidence in spinal pathologic conditions.
authors.affiliation: Department of Radiology, Gazi University School of Medicine, Besevler-Ankara, Turkey. yusuf@tr.net
authors.forename: A Y
authors.initials: AY
authors.lastname: Oner
authors.forename: T
authors.initials: T
authors.lastname: Tali
authors.forename: F
authors.initials: F
authors.lastname: Celikyay
authors.forename: A
authors.initials: A
authors.lastname: Celik
authors.forename: P
authors.initials: P
authors.lastname: Le Roux
mesh_terms: D000328:Adult; D000368:Aged; D016477:Artifacts; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D017352:Echo-Planar Imaging / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013122:Spinal Diseases / Q000473:pathology*; D013131:Spine / Q000473:pathology*; D014867:Water
chemical_list: D014867:Water