Effect of acetylsalicylic acid on aggregation of human platelets by Porphyromonas gingivalis.
This study investigated the effect of in vivo low-dose acetylsalicylic acid (ASA, aspirin) on human platelet aggregation induced in vitro by Porphyromonas gingivalis cells. Blood was collected from volunteers (n = 20), half of whom ingested 81 mg of aspirin 24 hours before donating blood. Low-dose aspirin inhibited P. gingivalis cell-induced platelet aggregation and produced an inverse correlation of inhibition to number of cells. At the higher concentration of cells used in this in vitro assay, aspirin inhibition was significant (P = 0.001); however, partial platelet activation was observed. The significance of partial platelet activation is discussed in this article, as is the relevance of platelet aggregation to the putative link between inflammatory periodontal disease and cardiovascular disease.
Whitaker
Eugene J
EJ
Oral Molecular Biology Research Laboratory, Temple University School of Dentistry, Philadelphia, Pennsylvania, USA.
Thomas
Ian S
IS
Falk
Jessica A
JA
Obebe
Akindeko
A
Hammond
Benjamin F
BF
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D016718:Arachidonic Acid / Q000494:pharmacology; D001241:Aspirin / Q000494:pharmacology*; D001792:Blood Platelets / Q000187:drug effects; D015169:Colony Count, Microbial; D006801:Humans; D066298:In Vitro Techniques; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D010979:Platelet Function Tests / Q000379:methods; D053657:Platelet-Rich Plasma / Q000187:drug effects; D016966:Porphyromonas gingivalis / Q000166:cytology* / Q000502:physiology
D000894:Anti-Inflammatory Agents, Non-Steroidal; D010975:Platelet Aggregation Inhibitors; D016718:Arachidonic Acid; D000244:Adenosine Diphosphate; D001241:Aspirin