Absorption of collagen: effects on the estimate of breast composition and related diagnostic implications.
The absorption spectrum of collagen powder is measured between 610 and 1040 nm by time-resolved transmittance spectroscopy. Absorption spectra of breast from healthy volunteers are then interpreted, adding collagen to the other absorbers previously considered (i.e., oxy- and deoxyhemoglobin, water, and lipids). A significant amount of collagen, depending on breast type, is estimated to be present. Adding collagen to the fitting procedure affects remarkably the estimated values of blood content and oxygenation. The quantification of collagen has potential implications for the assessment of breast density and cancer risk.
Taroni
Paola
P
Politecnico di Milano, Dipartimento di Fisica, ULTRAS-CNR-INFM and IFN-CNR, Piazza Leonardo da Vinci 32, I-20133 Milano, Italy. paola.taroni@fisi.polimi.it
Comelli
Daniela
D
Pifferi
Antonio
A
Torricelli
Alessandro
A
Cubeddu
Rinaldo
R
D001940:Breast / Q000737:chemistry* / Q000502:physiology*; D003094:Collagen / Q000737:chemistry* / Q000502:physiology*; D005260:Female; D006801:Humans; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013057:Spectrum Analysis / Q000379:methods*
D003094:Collagen