title: [Chemical constituents of the non-alkaloid fraction of Uncaria macrophylla].
abstract: OBJECTIVE
  To analyze the chemical constituents of the non-alkaloid fraction of Uncaria macrophylla.
  
  
  METHODS
  The constituents were separated and purified by silica gel chromatography and recrystalization, and their structures were identified by infrared, mass and nuclear magnetic resonance spectrometry.
  
  
  RESULTS
  Six compounds were isolated from the non-alkaloid fraction of Uncaria macrophylla, whose structures were identified as beta-sitosterol, beta-daucosterol, ursolic acid, alpha-amyrin acetate, 3beta, 6beta, 23-trihydroxyurs-12-en-28-oic acid, 3beta-hydroxyurs-12-en-27, and 3beta-hydroxyurs-12-en-27, 28-dioic acid, respectively.
  
  
  CONCLUSIONS
  Ursolic acid is the main component in the non-alkaloid fraction of Uncaria macrophylla. Alpha-amyrin acetate and 3beta-hydroxyurs-12-en-27, 28-dioic acid are isolated and characterized for the first time from this plant.
authors.affiliation: Second Hospital of Sun yet-sen University, Guangzhou 510120, China. junewu@tom.com
authors.forename: Jun-Yan
authors.initials: JY
authors.lastname: Wu
authors.forename: Guo-Cheng
authors.initials: GC
authors.lastname: Li
authors.forename: Ding-Yong
authors.initials: DY
authors.lastname: Wang
mesh_terms: D009828:Oleanolic Acid / Q000031:analogs & derivatives* / Q000302:isolation & purification; D014315:Triterpenes / Q000302:isolation & purification*; D032070:Uncaria / Q000737:chemistry*; D000097245:Ursolic Acid
chemical_list: D009828:Oleanolic Acid; D014315:Triterpenes; D000097245:Ursolic Acid; C528818:3beta,6beta,23-trihydroxyurs-12-en-28-oic acid; C528817:3beta-hydroxyurs-12-en-27, 28-dioic acid; C000265:beta-amyrin acetate