title: Neonatal listeriosis.
abstract: In Western developed countries, Listeria monocytogenesis not an uncommon pathogen in neonates. However, neonatal listeriosis has rarely been reported in Taiwan. We describe two cases collected from a single medical institute between 1990 and 2005. Case 1 was a male premature baby weighing 1558 g with a gestational age of 31 weeks whose mother had fever with chills 3 days prior to delivery. Generalized maculopapular rash was found after delivery and subtle seizure developed. Both blood and cerebrospinal fluid culture collected on the 1st day yielded L. monocytogenes. In addition, he had ventriculitis complicated with hydrocephalus. Neurologic development was normal over 1 year of follow-up after ventriculoperitoneal shunt operation. Case 2 was a 28-weeks' gestation male premature baby weighing 1180 g. Endotracheal intubation and ventilator support were provided after delivery due to respiratory distress. Blood culture yielded L. monocytogenes. Cerebrospinal fluid showed pleocytosis but the culture was negative. Brain ultrasonography showed ventriculitis. Sudden deterioration with cyanosis and bradycardia developed on the 8th day and he died on the same day. Neonatal listeriosis is uncommon in Taiwan, but has significant mortality and morbidity. Early diagnosis of perinatal infection relies on high index of suspicion in perinatal health care professionals.
authors.affiliation: Department of Pediatrics, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan.
authors.forename: Shih-Yu
authors.initials: SY
authors.lastname: Chen
authors.forename: Frank Leigh
authors.initials: FL
authors.lastname: Lu
authors.forename: Ping-Ing
authors.initials: PI
authors.lastname: Lee
authors.forename: Chun-Yi
authors.initials: CY
authors.lastname: Lu
authors.forename: Chien-Yi
authors.initials: CY
authors.lastname: Chen
authors.forename: Hung-Chieh
authors.initials: HC
authors.lastname: Chou
authors.forename: Po-Nien
authors.initials: PN
authors.lastname: Tsao
authors.forename: Wu-Shiun
authors.initials: WS
authors.lastname: Hsieh
mesh_terms: D017809:Fatal Outcome; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D008089:Listeria monocytogenes / Q000302:isolation & purification; D008088:Listeriosis / Q000097:blood / Q000134:cerebrospinal fluid / Q000175:diagnosis*; D008297:Male; D013624:Taiwan