title: [Molecular and chemical mechanism of Trichomonas vaginalis-induced contact-dependent cytotoxicity].
abstract: Trichomonas vaginalis parasitizes in human genitourinary tract. The protozoon adhering to target cell plays a critical role in its contact-dependent cytotoxicity. The enzymes synthesized by T.voginalis can hurt vaginalis epithelial cells (VECs) directly. The focal immune reaction in the location parasitized by the parasite may provide an immunologic protection. Meanwhile, inflammatory factors and immune cells may aggravate the situation. In general, the T. vaginalis-induced contact-dependent cytotoxicity is a result of the involvement of some molecular and chemical factors.
authors.affiliation: Department of Parasitology, School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, China.
authors.forename: Shu-guo
authors.initials: SG
authors.lastname: Yang
authors.forename: Chao-nan
authors.initials: CN
authors.lastname: Tie
authors.forename: Ya-jing
authors.initials: YJ
authors.lastname: Wang
mesh_terms: D000818:Animals; D017209:Apoptosis; D051017:Apoptosis Regulatory Proteins / Q000378:metabolism; D015815:Cell Adhesion Molecules / Q000378:metabolism; D002470:Cell Survival; D003546:Cysteine Endopeptidases / Q000378:metabolism; D005260:Female; D006801:Humans; D015800:Protozoan Proteins / Q000378:metabolism; D014247:Trichomonas Vaginitis / Q000378:metabolism / Q000469:parasitology / Q000473:pathology*; D014246:Trichomonas vaginalis / Q000254:growth & development* / Q000378:metabolism
chemical_list: C096723:AP65-1 protein, Trichomonas vaginalis; D051017:Apoptosis Regulatory Proteins; D015815:Cell Adhesion Molecules; D015800:Protozoan Proteins; D003546:Cysteine Endopeptidases