title: Review of the economic and quality-of-life burden of cervical human papillomavirus disease.
abstract: OBJECTIVE
  The purpose of this study was to conduct a systematic literature review on the economic burden and health-related quality-of-life impact of cervical human papillomavirus disease.
  
  
  METHODS
  A systematic review of cost-of-illness studies and health-related quality-of-life studies was conducted. PubMed, Embase, and PsycINFO databases were searched with the use of predefined terms.
  
  
  RESULTS
  Nine economic and 24 quality-of-life studies were identified. The annual health care costs of human papillomavirus-related conditions in the United States range from 2.25-4.6 billion dollars (2005 US dollars). The burden of human papillomavirus is second only to human immunodeficiency virus among sexually transmitted diseases. Health-related quality-of-life areas that are impacted substantially by human papillomavirus include emotional, social, and sexual functioning.
  
  
  CONCLUSIONS
  The economic and quality-of-life burden of cervical human papillomavirus disease is significant and highlights the need for treatment and prevention options for this condition.
authors.affiliation: Health Care Analytics Group, United BioSource Corporation, Bethesda, MD, USA. rachael.fleurence@unitedbiosource.com
authors.forename: Rachael L
authors.initials: RL
authors.lastname: Fleurence
authors.forename: Julia M
authors.initials: JM
authors.lastname: Dixon
authors.forename: Tsveta F
authors.initials: TF
authors.lastname: Milanova
authors.forename: Kathleen M
authors.initials: KM
authors.lastname: Beusterien
mesh_terms: D017281:Cost of Illness; D005260:Female; D006801:Humans; D030361:Papillomavirus Infections / Q000191:economics*; D011788:Quality of Life; D002583:Uterine Cervical Neoplasms / Q000191:economics*