[14C-labelled triolein absorption and esterification in rats treated with neomycin].
Intragastrically administered 14C-triolein was observed in fistula-derived lymph from rats treated with neomycin and controls. Absorption was much reduced in the treated animals, indicating (contrary to the literature data) that neomycin malabsorption also occurs in this species. The slight amount absorbed followed normal routes. It is suggested that the antibiotic acts on the intestinal content and not on the mucosa.
Cesano
L
L
Department of Special Medical Pathology and Clinical Methodology, University of Turin, Italy.
Matone
S
S
Doglio
R
R
Vaccarino
A
A
Roveyaz
L
L
D000284:Administration, Oral; D000714:Anastomosis, Surgical; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002404:Catheterization; D004951:Esterification / Q000187:drug effects; D005766:Gastrointestinal Contents / Q000187:drug effects*; D007408:Intestinal Absorption / Q000187:drug effects*; D008196:Lymph / Q000378:metabolism; D008286:Malabsorption Syndromes / Q000139:chemically induced* / Q000503:physiopathology; D009355:Neomycin / Q000494:pharmacology* / Q000633:toxicity; D011168:Portal System / Q000378:metabolism; D051381:Rats; D045602:Steatorrhea / Q000139:chemically induced; D013270:Stomach; D013897:Thoracic Duct / Q000601:surgery; D014304:Triolein / Q000493:pharmacokinetics*
D000900:Anti-Bacterial Agents; D014304:Triolein; D009355:Neomycin