Nested case-control study of energy regulation candidate gene single nucleotide polymorphisms and breast cancer.
BACKGROUND
Accumulating evidence suggests that energy regulation, particularly insulin resistance, may influence breast cancer risk.


METHODS
The associations between single nucleotide polymorphisms (SNPs) in energy regulation candidate genes and postmenopausal breast cancer risk were evaluated. Conditional logistic regression was run on 488 matched case-control pairs from the American Cancer Society's Cancer Prevention Study II Nutrition Cohort. The studied SNPs were INS+1127 PstI (rs3842752), INSR H1085H (rs1799817) and PPARy Prol2Ala (rs1801282).


RESULTS
A significantly lower breast cancer risk was found among women homozygous for the T allele of INSR H1085H. A marginally significant increased risk of breast cancer was observed among women homozygous for the Ala allele of PPARgamma Pro12Ala. No significant association was observed between INS+ 1127 PstI and breast cancer risk.


CONCLUSIONS
Our results suggest that polymorphisms in these energy regulation candidate genes may be associated with risk of breast cancer, but replication in larger studies is needed.
Wang
Yiting
Y
Department of Epidemiology and Surveillance Research, American Cancer Society, 1599 Clifton Road NE, Atlanta, Georgia, GA 30329-4251, USA. yiting.wang@cancer.org
McCullough
Marjorie L
ML
Stevens
Victoria L
VL
Rodriguez
Carmen
C
Jacobs
Eric J
EJ
Teras
Lauren R
LR
Pavluck
Alexandre L
AL
Thun
Michael J
MJ
Calle
Eugenia E
EE
D000368:Aged; D001943:Breast Neoplasms / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D007333:Insulin Resistance; D015810:Linkage Disequilibrium; D016015:Logistic Models; D008875:Middle Aged; D016017:Odds Ratio; D047495:PPAR gamma / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D011972:Receptor, Insulin / Q000235:genetics
D047495:PPAR gamma; D011972:Receptor, Insulin