title: Additional support for linkage of schizophrenia and bipolar disorder to chromosome 3q29.
abstract: After publishing a genome scan and follow-up fine mapping, suggesting schizophrenia and bipolar disorder linkage to chromosome 3q29, we now genotyped 11 additional SNPs (single nucleotide polymorphisms), in order to narrow down a potential candidate region. Linkage was performed using the GENEHUNTER program version 2.1r3. A NPL score Z(all) of 3.891 (p=0.000156) was observed with SNP rs225. In short, we found significant linkage scores most telomeric on chromosome 3q29, spanning 3.46 Mbp (7 SNPs).
authors.affiliation: Department of General Psychiatry, University Hospital for Psychiatry, Medical University Vienna, Austria. alexandra.schosser@meduniwien.ac.at
authors.forename: Alexandra
authors.initials: A
authors.lastname: Schosser
authors.forename: Karoline
authors.initials: K
authors.lastname: Fuchs
authors.forename: Theresa
authors.initials: T
authors.lastname: Scharl
authors.forename: Friedrich
authors.initials: F
authors.lastname: Leisch
authors.forename: Ursula
authors.initials: U
authors.lastname: Bailer
authors.forename: Siegfried
authors.initials: S
authors.lastname: Kasper
authors.forename: Werner
authors.initials: W
authors.lastname: Sieghart
authors.forename: Kurt
authors.initials: K
authors.lastname: Hornik
authors.forename: Harald N
authors.initials: HN
authors.lastname: Aschauer
mesh_terms: D002874:Chromosome Mapping; D002893:Chromosomes, Human, Pair 3; D017931:DNA Primers; D005819:Genetic Markers; D005838:Genotype; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D015203:Reproducibility of Results; D012559:Schizophrenia / Q000235:genetics*; D016615:Telomere / Q000235:genetics
chemical_list: D017931:DNA Primers; D005819:Genetic Markers