title: Poly-L-lactic acid beta-tricalcium phosphate screws: a preliminary in vivo biocompatibility study.
abstract: The aim of this study is to assess the biocompatibility of two types of Poly-L-lactic acid (PLLA) screws (with either hydroxyapatite (HA) or beta-tricalcium phosphate (beta-TCP)) implanted in the left femur of four sheep euthanized at 42, 50, 57 and 84 days after surgery. Titanium screws were also implanted for comparison purposes. No signs of inflammation were seen in the 240 specimens. A rating of "+/-" for macrophages and "-" for neutrophils was assigned to all specimens. All specimens were assigned a rating which ranged from "+/-" to "+++" for fibroblasts and osteoblasts. The presence of macrophages, neutrophils and fibroblasts/osteoblasts was not statistically different for the four implantation periods. PLLA implants with beta-TCP have a biocompatibility comparable to PLLA implants with HA.
authors.forename: N
authors.initials: N
authors.lastname: Magarelli
authors.forename: M A
authors.initials: MA
authors.lastname: Savastano
authors.forename: D
authors.initials: D
authors.lastname: Palmieri
authors.forename: R
authors.initials: R
authors.lastname: Zappacosta
authors.forename: G
authors.initials: G
authors.lastname: Lattanzio
authors.forename: V
authors.initials: V
authors.lastname: Salini
authors.forename: C A
authors.initials: CA
authors.lastname: Orso
authors.forename: G
authors.initials: G
authors.lastname: Guglielmi
authors.forename: C
authors.initials: C
authors.lastname: Colosimo
mesh_terms: D020341:Absorbable Implants; D000818:Animals; D001672:Biocompatible Materials; D001843:Bone Cements; D001863:Bone Screws; D001842:Bone and Bones / Q000166:cytology*; D002130:Calcium Phosphates; D005269:Femur / Q000473:pathology; D019344:Lactic Acid; D008422:Materials Testing; D011091:Polyesters; D011108:Polymers; D019904:Polymethyl Methacrylate; D012756:Sheep; D014025:Titanium
chemical_list: D001672:Biocompatible Materials; D001843:Bone Cements; D002130:Calcium Phosphates; D011091:Polyesters; D011108:Polymers; C485817:beta-tricalcium phosphate; D019344:Lactic Acid; C033616:poly(lactide); D019904:Polymethyl Methacrylate; D014025:Titanium