A polysaccharide-peptide complex from abalone mushroom (Pleurotus abalonus) fruiting bodies increases activities and gene expression of antioxidant enzymes and reduces lipid peroxidation in senescence-accelerated mice.
The antioxidant effects of a polysaccharide-peptide complex (F22) from mushroom (Pleurotus abalonus)-fruiting bodies were studied. The activities of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) in the liver, kidney, and brain of senescence-accelerated mice showed a marked increase after treatment with the polysaccharide-peptide complex. Concurrently, the gene expression levels of SOD, CAT, and GPx, as determined with real-time polymerase chain reaction, were up-regulated in the liver, kidney, and brain, whereas the MDA content in these organs declined. The maximal lifespan of the mice was prolonged.
Li
L
L
Department of Microbiology, College of Life Science, Nankai University, Tianjin, China.
Ng
T B
TB
Song
M
M
Yuan
F
F
Liu
Z K
ZK
Wang
C L
CL
Jiang
Y
Y
Fu
M
M
Liu
F
F
D000375:Aging / Q000187:drug effects*; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001921:Brain / Q000201:enzymology; D002374:Catalase / Q000235:genetics / Q000378:metabolism; D048690:Fruiting Bodies, Fungal / Q000378:metabolism*; D015870:Gene Expression / Q000187:drug effects*; D005979:Glutathione Peroxidase / Q000235:genetics / Q000378:metabolism; D007668:Kidney / Q000201:enzymology; D015227:Lipid Peroxidation / Q000187:drug effects*; D008099:Liver / Q000201:enzymology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D020076:Pleurotus / Q000378:metabolism*; D011509:Proteoglycans / Q000494:pharmacology*; D013482:Superoxide Dismutase / Q000235:genetics / Q000378:metabolism
D000975:Antioxidants; D011509:Proteoglycans; C093216:polysaccharide peptide; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase