title: [The efficacy and safety of docetaxel for elderly advanced breast cancer patients].
abstract: We studied the efficacy and safety of docetaxel (DOC) for elderly breast cancer patients. Between September 1997 and June 2003, five consecutive women with advanced breast cancers who were 75 years of age or older received DOC at a dose of 60 mg/m(2) every three weeks. No premedications to prevent hypersensitive reactions and fluid retention by DOC were given. The number of DOC dosages per case was 5-16 times (12 times the median) and the relative dose intensity (RDI) was 80-100% (95% of medians). Objective partial responses were observed in all patients. The median time to partial response was 21 days (range: 21-50 days). The median time to treatment failure was 12 months (range: 5-22 months). The grade and the frequency of major side effects were the following: leukocytopenia of grade 3 (80%), edema of grade 2-3 (40%), and alopecia of grade 2 (100%). It was concluded from these findings that DOC could be safely and effectively administered to elderly advanced breast cancer patients.
authors.affiliation: Dept. of Surgery, Oita Prefectural Hospital.
authors.forename: Hideya
authors.initials: H
authors.lastname: Tashiro
authors.forename: Kojiro
authors.initials: K
authors.lastname: Mashino
authors.forename: Kotaro
authors.initials: K
authors.lastname: Shibahara
authors.forename: Kazuya
authors.initials: K
authors.lastname: Endo
authors.forename: Kyuzo
authors.initials: K
authors.lastname: Fujii
authors.forename: Mizuki
authors.initials: M
authors.lastname: Ninomiya
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Ikeda
authors.forename: Hisanobu
authors.initials: H
authors.lastname: Sakata
mesh_terms: D000368:Aged; D000505:Alopecia / Q000139:chemically induced; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology; D000077143:Docetaxel; D004334:Drug Administration Schedule; D004487:Edema / Q000139:chemically induced; D005260:Female; D006801:Humans; D007970:Leukopenia / Q000139:chemically induced; D008198:Lymph Nodes / Q000473:pathology*; D008207:Lymphatic Metastasis; D012074:Remission Induction; D043823:Taxoids / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D000970:Antineoplastic Agents; D043823:Taxoids; D000077143:Docetaxel