title: Accurate planning of minimally invasive surgery of parathyroid adenomas by means of [(99m)Tc]MIBI SPECT.
abstract: OBJECTIVE
  The aim of the study was to evaluate the clinical role or [(99m)Tc]MIBI SPECT in selecting primary hyperparathyroid (PHPT) patients for minimally invasive radioguided surgery (MIRS).
  
  
  METHODS
  One hundred and forty-one consecutive PHPT patients were studied by a single-session [(99m)Tc]Percethnetate/[(99m)Tc]MIBI subtraction scintigraphy, followed by [(99m)Tc]MIBI SPECT in order to localize hyperfunctioning parathyroid adenoma (PA) and plan the surgical approach.
  
  
  RESULTS
  A solitary PA was depicted at preoperative scintigraphy in 135 of 141 patients (95.7%), two or more PA in 5 patients, and was negative in 6 patients (4.3%). In 27 patients, the PA was located deep in the paraesophageal/paratracheal space. One hundred and twenty-four patients (in 18 of them the PA was located deeply in the neck) underwent successful MIRS using the low 37 MBq (1 mCi) [(99m)Tc]MIBI dose protocol. Intraoperative quick parathyroid hormone (QPTH) assay demonstrated a fall >50% in respect to the baseline value in all patients, confirming successful parathyroidectomy. After a follow-up of 6 to 37 months (median 18 months), no case of persistent/recurrent PHPT was recorded. When comparing the parathyroid to background (P/B) ratio measured at planar and SPECT preoperative scintigraphy with that measured intraoperatively with the gamma probe, a significant linear correlation was found between the SPECT and intraoperative gamma probe measurements (r = 0.91; P <0.01) while no correlation was found with planar scintigraphic data.
  
  
  CONCLUSIONS
  Our data suggest that the P/B ratio calculated by means of [(99m)Tc]MIBI SPECT is more accurate in predicting the intraoperative measurements with the intraoperative gamma probe. Thus, a preoperative [(99m)Tc]MIBI SPECT acquisition should be recommended for a better selection of PHPT patients to offer MIRS.
authors.affiliation: Nuclear Medicine Unit, PET Service, S Maria della Misericordia Hospital, Rovigo, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Massaro
authors.forename: S
authors.initials: S
authors.lastname: Cittadin
authors.forename: L
authors.initials: L
authors.lastname: Rampin
authors.forename: E
authors.initials: E
authors.lastname: Banti
authors.forename: F
authors.initials: F
authors.lastname: Rossi
authors.forename: M R
authors.initials: MR
authors.lastname: Pelizzo
authors.forename: P C
authors.initials: PC
authors.lastname: Muzzio
authors.forename: D
authors.initials: D
authors.lastname: Rubello
mesh_terms: D000236:Adenoma / Q000000981:diagnostic imaging* / Q000601:surgery; D000465:Algorithms; D005500:Follow-Up Studies; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007430:Intraoperative Care; D019060:Minimally Invasive Surgical Procedures; D010281:Parathyroid Hormone / Q000097:blood; D010282:Parathyroid Neoplasms / Q000000981:diagnostic imaging* / Q000601:surgery; D016105:Parathyroidectomy; D011300:Preoperative Care; D019275:Radiopharmaceuticals / Q000627:therapeutic use*; D025321:Surgery, Computer-Assisted; D017256:Technetium Tc 99m Sestamibi; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D010281:Parathyroid Hormone; D019275:Radiopharmaceuticals; D017256:Technetium Tc 99m Sestamibi