title: Ovarian cancer activity of cyclic amine and thiaether metal complexes.
abstract: A thiaether metal complex 1-aza-4,7-dithiacyclononane-RhCl3, 2, and cyclic amine metal complexes tacn-CuBr2, 3, and Me3tacn-RuCl3, 4, have been evaluated for anticancer activity against the ovarian cancer cell line NuTu-19 and for cell toxicity against the noncancerous ovarian tissue cell line OVepi. Specifically, metal complex 2 is active when compared to cisplatin at micromolar concentrations using the MTT and cell invasion assay. The in vitro results reported warrant further evaluation of metal complex 2 in living systems.
authors.affiliation: The University of Akron, 190 East Buchtel Commons, Akron, Ohio 44325, USA.
authors.forename: Doug A
authors.initials: DA
authors.lastname: Medvetz
authors.forename: Kimberly D
authors.initials: KD
authors.lastname: Stakleff
authors.forename: Tara
authors.initials: T
authors.lastname: Schreiber
authors.forename: Paul D
authors.initials: PD
authors.lastname: Custer
authors.forename: Khadijah
authors.initials: K
authors.lastname: Hindi
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Panzner
authors.forename: Denise D
authors.initials: DD
authors.lastname: Blanco
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Taschner
authors.forename: Claire A
authors.initials: CA
authors.lastname: Tessier
authors.forename: Wiley J
authors.initials: WJ
authors.lastname: Youngs
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002460:Cell Line; D045744:Cell Line, Tumor; D003300:Copper; D004354:Drug Screening Assays, Antitumor; D005260:Female; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D010051:Ovarian Neoplasms; D051381:Rats; D011916:Rats, Inbred F344; D012238:Rhodium; D012428:Ruthenium; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D009942:Organometallic Compounds; C519522:trichloro(1-aza-4,7-dithiacyclononane)rhodium(III); D003300:Copper; D012428:Ruthenium; D012238:Rhodium