title: Failure to confirm an association between the PLXNA2 gene and schizophrenia in a Japanese population.
abstract: Plexins are receptors for multiple classes of semaphorins, either alone or in combination with neuropilins. Plexins participate in many cellular events that include axonal repulsion, axonal attraction, cell migration, axon pruning, and synaptic plasticity. PLXNA2 maps to chromosome 1q32. Several linkage studies reported schizophrenia susceptibility loci in the 1q22-42 region. A recent study reported that intronic single nucleotide polymorphisms (SNPs) of PLXNA2 were associated with schizophrenia in a European American population. We attempted to replicate this finding in a Japanese sample of 336 patients with schizophrenia and 304 controls. In addition, we examined 3 non-synonymous SNPs (Arg5Gln, GLn57Arg, and Ala267Thr) in PLXNA2. Genotyping was performed by the TaqMan allelic discrimination assay. There was no significant difference in genotype or allele distribution of either the 4 intronic SNPs or the 3 non-synonymous SNPs between patients and controls. Furthermore, haplotype-based analyses did not provide evidence for an association. These results suggest that PLXNA2 may not play a major role in the development of schizophrenia in our Japanese sample.
authors.affiliation: Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1, Ogawahigashi, Kodaira, Tokyo, 187-8502, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Fujii
authors.forename: Yoshimi
authors.initials: Y
authors.lastname: Iijima
authors.forename: Hitomi
authors.initials: H
authors.lastname: Kondo
authors.forename: Tomoko
authors.initials: T
authors.lastname: Shizuno
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Hori
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Nakabayashi
authors.forename: Kunimasa
authors.initials: K
authors.lastname: Arima
authors.forename: Osamu
authors.initials: O
authors.lastname: Saitoh
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kunugi
mesh_terms: D000328:Adult; D000483:Alleles; D016009:Chi-Square Distribution; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011956:Receptors, Cell Surface / Q000235:genetics*; D012559:Schizophrenia / Q000453:epidemiology / Q000235:genetics*
chemical_list: D009419:Nerve Tissue Proteins; C515995:PLXNA2 protein, human; D011956:Receptors, Cell Surface