A flow reactor process for the synthesis of peptides utilizing immobilized reagents, scavengers and catch and release protocols.
A general flow process for the multi-step assembly of peptides has been developed and this procedure has been used to successfully construct a series of Boc, Cbz and Fmoc N-protected dipeptides in excellent yields and purities, including an extension of the method to enable the preparation of a tripeptide derivative.
Baxendale
Ian R
IR
Innovative Technology Centre, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK CB2 1EW.
Ley
Steven V
SV
Smith
Christopher D
CD
Tranmer
Geoffrey K
GK
D000596:Amino Acids / Q000737:chemistry; D007202:Indicators and Reagents; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation* / Q000379:methods*; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry*
D000596:Amino Acids; D007202:Indicators and Reagents; D010455:Peptides