title: [Neurosurgical treatment of pain].
abstract: BACKGROUND
  Surgical treatment of chronic pain includes destructive procedures (neurectomy, rhizotomy, sympathectomy), often referred to as ablative, and accompanied by high morbidity and mortality rates.
  During the past three decades, thanks to current knowledge on chronic pain mechanisms and technological developments, such as improved microsurgical and stereotactic techniques, guided by computerized tomography, magnetic resonance imaging and neural tissue impendance monitoring, the majority of ablative procedures have been replaced by new methods. Among them, a few can be considered as selectively and minimally ablative (microsurgical spinothalamic cordotomy, dorsal root entry zone lesions, limited midline myelotomy) and others as neuroaugumentative procedures for neuromodulatory proceses (deep brain structures and spinal cord stimulation, drug-delivery systems).
  Cordotomy is very effective in pain treatment and it may produce complete abolishment of pain, especially in patients suffering from neoplastic invasion of the brachial plexus (Pancoast's syndrome) or lumbosacral plexus. Dorsal root entry zone operation is generally the only treatment option for pain due to root avulsion and segmental pain in spinal cord injury. Spinal cord stimulation is useful in management of pain following peripheral nerve injury. Deep brain stimulation is a promising treatment of central pain.
  
  
  CONCLUSIONS
  The purpose of this review is to draw attention to neurosurgical approaches to treatment of chronic and opioid-resistant pain.
authors.affiliation: Klinicki centar Srbije, Beograd, Institut za neurohirurgiju. eugens@ptt.yu
authors.forename: Eugen
authors.initials: E
authors.lastname: Slavik
mesh_terms: D002908:Chronic Disease; D006801:Humans; D019635:Neurosurgical Procedures; D010146:Pain / Q000209:etiology / Q000601:surgery*