title: Increased plasma visfatin concentrations in women with polycystic ovary syndrome.
abstract: OBJECTIVE
  To test the hypothesis that plasma visfatin concentrations will be higher in women with polycystic ovary syndrome (PCOS) than in women without PCOS.
  
  
  METHODS
  Clinical study.
  
  
  METHODS
  University hospital.
  
  
  METHODS
  A total of 52 women were evaluated. Twenty-six had PCOS, and the remaining 26 were healthy women with regular menstrual cycles who served as control subjects.
  
  
  METHODS
  Plasma visfatin concentrations were analyzed with the use of RIA.
  
  
  METHODS
  Serum concentrations of FSH, LH, TSH, PRL, T, insulin, E(2), and visfatin.
  
  
  RESULTS
  Plasma visfatin concentrations were significantly higher in the PCOS group (336.8 +/- 50.2 ng/mL) than in the healthy control group (282.4 +/- 43.3 ng/mL). Logistic regression analysis indicated a significant association between odds ratio (OR) values of PCOS and visfatin levels (OR = 2.81; 95% confidence interval [CI], 2.74-2.90), T (OR = 3.39; 95% CI, 2.85-4.16), and LH levels (OR = 3.49; 95% CI, 2.79-4.56). There was no correlation between plasma visfatin concentrations and T, insulin, and LH levels or age in either the PCOS group or the control group. We observed that plasma visfatin levels were positively correlated with body mass index in the PCOS group (r = 0.396, r(2) = 0.157) but not in the control group (r = -0.328, r(2) = 0.108).
  
  
  CONCLUSIONS
  Our data show that women with PCOS exhibit higher plasma visfatin levels than control subjects of similar body mass index. Further studies are required to clarify the etiology and effects of hypervisfatinemia in women with PCOS.
authors.affiliation: Department of Obstetrics and Gynecology, Graduate Institute of Medicine, College of Medicine, Kaohsiung, Taiwan.
authors.forename: Te-Fu
authors.initials: TF
authors.lastname: Chan
authors.forename: Yi-Ling
authors.initials: YL
authors.lastname: Chen
authors.forename: Hung-Hseng
authors.initials: HH
authors.lastname: Chen
authors.forename: Chien-Hung
authors.initials: CH
authors.lastname: Lee
authors.forename: Shiang-Bin
authors.initials: SB
authors.lastname: Jong
authors.forename: Eing-Mei
authors.initials: EM
authors.lastname: Tsai
mesh_terms: D000328:Adult; D015992:Body Mass Index; D016022:Case-Control Studies; D016207:Cytokines / Q000097:blood*; D005260:Female; D006801:Humans; D054409:Nicotinamide Phosphoribosyltransferase; D011085:Polycystic Ovary Syndrome / Q000097:blood*
chemical_list: D016207:Cytokines; D054409:Nicotinamide Phosphoribosyltransferase; C085455:nicotinamide phosphoribosyltransferase, human