Long-term efficacy of tonsillectomy in Chinese patients with IgA nephropathy.
BACKGROUND
To investigate the clinical efficacy of tonsillectomy on long-term clinical remission and renal survival of immunoglobulin A nephropathy (IgAN) patients in China.


METHODS
We performed a 130-month retrospective case-control study of 112 patients with idiopathic biopsy-diagnosed IgAN from 1983 to 1999. Fifty-four patients underwent tonsillectomy and 58 patients did not. The clinical remission rate during follow-up and variables to predict clinical remission were estimated by chi2 test and multivariate Cox regression analysis; renal survival was evaluated by Kaplan-Meier analysis.


RESULTS
Up to 2006, the follow-up period lasted 130 +/- 50.3 months (60-276 months). The clinical remission rate was 46.3% in patients with tonsillectomy and 27.6% in those without tonsillectomy during follow-up. Multivariate analysis demonstrated that tonsillectomy was not an independent impact factor for renal clinical remission (p = 0.386). By Kaplan-Meier analysis, there was no significant difference in renal survival rate between patients with tonsillectomy and those without tonsillectomy (p = 0.059).


CONCLUSIONS
The clinical remission rate in IgAN patients with tonsillectomy was higher than that in patients without tonsillectomy during follow-up. But within 130 months, it was difficult to find statistical difference in renal survival between IgAN patients with and without tonsillectomy.
Chen
Yu
Y
Research Institute of Nephrology, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China.
Tang
Zheng
Z
Wang
Qingwen
Q
Yu
Yusheng
Y
Zeng
Caihong
C
Chen
Huiping
H
Liu
Zhi-hong
ZH
Li
Lei-shi
LS
D000293:Adolescent; D000328:Adult; D044466:Asian People; D016022:Case-Control Studies; D002681:China; D003404:Creatinine / Q000097:blood; D005260:Female; D005922:Glomerulonephritis, IGA / Q000097:blood / Q000276:immunology* / Q000503:physiopathology / Q000601:surgery*; D006801:Humans; D008297:Male; D012141:Respiratory Tract Infections / Q000150:complications / Q000601:surgery; D012189:Retrospective Studies; D014068:Tonsillectomy; D016896:Treatment Outcome
D003404:Creatinine