The association of dental caries with blood lead in children when adjusted for IQ and neurobehavioral performance.
Associations between childhood lead exposures and dental caries in children have been reported for over 30 years, with widely varying findings and conclusions, and using measures of lead exposure which ranged from food sources and water to tooth, hair or blood lead concentrations.


OBJECTIVE
This study examined the relationship of lead exposure and dental caries in a population of normatively healthy children.


METHODS
This cross-sectional study used a population of 507 children aged 8-12 who were participating in a clinical trial of dental materials to examine the relationship between lead and caries. Blood lead concentrations and dental caries were examined for association in both primary and permanent teeth. Because it is possible that neurobehavioral status could be associated with both lead exposure and dental caries prevalence, we also examined neurobehavioral status of the subjects.


RESULTS
A gender-specific association (males only) between lead exposure and dental caries was found in primary teeth only. Neurobehavioral measures and IQ were not associated with caries status in this population.


CONCLUSIONS
This study did not support neurobehavioral status as mediating any association between lead exposure and caries in a normatively healthy population. A gender-specific association between lead and caries not previously reported was found in primary teeth, and no biological explanation for this has been suggested. We conclude that this study provides only weak evidence, if any, for an association of low-level lead exposure with dental caries.
Martin
Michael D
MD
Box 356370, Department of Oral Medicine, University of Washington, Seattle, WA 98195, USA. mickeym@u.washington.edu <mickeym@u.washington.edu>
Benton
Tonya
T
Bernardo
Mario
M
Woods
James S
JS
Townes
Brenda D
BD
Luis
Henrique
H
Leitão
Jorge
J
Rosenbaum
Gail
G
Castro-Caldas
Alexandre
A
Pavão
Isabel
I
Rue
Tessa
T
DeRouen
Timothy A
TA
D001288:Attention; D002648:Child; D003731:Dental Caries / Q000097:blood* / Q000453:epidemiology*; D004781:Environmental Exposure; D004785:Environmental Pollutants / Q000097:blood*; D005260:Female; D006801:Humans; D007361:Intelligence Tests; D007854:Lead / Q000097:blood*; D008297:Male; D008568:Memory; D011174:Portugal / Q000453:epidemiology; D011597:Psychomotor Performance; D012737:Sex Factors; D014094:Tooth, Deciduous
D004785:Environmental Pollutants; D007854:Lead