Expression and function of galectin-1 in adult neural stem cells.
Neural stem cells (NSCs) in the adult mammalian brain proliferate and continuously produce new neurons. To date, there has been little research into the functions of lectins in adult NSCs. Recently, we reported that a lectin, galectin-1, is expressed on adult NSCs and promotes their proliferation through its carbohydrate-binding ability. This evidence raises the possibility that glycans play roles in the proliferation of adult NSCs.
Sakaguchi
M
M
Department of Physiology, Keio University School of Medicine, Shinanomachi, Tokyo, Japan.
Imaizumi
Y
Y
Okano
H
H
D053687:Adult Stem Cells / Q000166:cytology / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000166:cytology / Q000378:metabolism; D049109:Cell Proliferation / Q000187:drug effects; D037483:Galectin 1 / Q000096:biosynthesis* / Q000494:pharmacology; D006801:Humans; D008954:Models, Biological; D009474:Neurons / Q000166:cytology / Q000378:metabolism*
D037483:Galectin 1