title: Regional cerebral blood flow and blood volume in patients with subcortical arteriosclerotic encephalopathy (SAE).
abstract: The aim of the present study was a detailed analysis of the regional cerebral blood flow and blood volume in patients with subcortical arteriosclerotic encephalopathy (SAE) by means of functional magnetic resonance imaging (MRI). A group of 26 patients with SAE and a group of 16 age-matched healthy volunteers were examined. Using a well-established dynamic susceptibility contrast-enhanced MRI method, the regional cerebral blood flow (rCBF) and blood volume (rCBV) were quantified for each subject in 12 different regions in the brain parenchyma. As compared to healthy volunteers, patients with SAE showed significantly reduced rCBF and rCBV values in white matter regions and in the occipital cortex. Regions containing predominantly grey matter show almost normal rCBF and rCBV values. In conclusion, quantitative analysis of rCBF and rCBV values demonstrates clearly that SAE is a disease that is associated with a reduced microcirculation predominantly in white matter.
authors.affiliation: Institut für Klinische Radiologie, Universitätsklinik Mannheim, der Universität Heidelberg, Lauertstr 23, D-69242, Mühlhausen, Germany. friedjmgue@t-online.de
authors.forename: Friedemann J
authors.initials: FJ
authors.lastname: Gückel
authors.forename: Gunnar
authors.initials: G
authors.lastname: Brix
authors.forename: Michael
authors.initials: M
authors.lastname: Hennerici
authors.forename: Robert
authors.initials: R
authors.lastname: Lucht
authors.forename: Christine
authors.initials: C
authors.lastname: Ueltzhöffer
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Neff
mesh_terms: D000368:Aged; D001810:Blood Volume; D002560:Cerebrovascular Circulation; D015140:Dementia, Vascular / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male