title: Prognostic factors in Hungarian breast cancer patients.
abstract: BACKGROUND
  Breast cancer is the most common cancer among women, with variable outcomes, justifying a continuous search for new parameters to predict accurate prognosis and indicate suitable adjuvant therapy for patients.
  
  
  METHODS
  Fourty-four stage I-III breast cancer specimens were investigated immunohistochemically for the expression of cyclooxygenase-2 enzyme (COX-2), hormone receptors, tumor suppressor gene p53, oncogene HER2 and proliferation marker Ki-67. Additionally, twelve specimens were also investigated for the presence of the phosphorylated extracellular signal-regulated kinase (pERK).
  
  
  RESULTS
  It was demonstrated that expressions of biological markers were related to each other (ER to p53 and Ki-67, COX-2 to ER, PgR, Ki-67 and p53, Ki-67 to p53 and PgR, p53 to PgR).
  
  
  CONCLUSIONS
  Our data indicate that concomitant immunohistochemical evaluation of cyclooxygenase-2, hormone receptors, p53 and Ki-67 may be of clinical value in determining an accurate prognosis.
authors.affiliation: University of Pécs, Department of Public Health and Preventive Medicine, Szigeti u 12, 7624 Pécs, Hungary. edit.nadasi@aok.pte.hu
authors.forename: Edit
authors.initials: E
authors.lastname: Nádasi
authors.forename: Béla
authors.initials: B
authors.lastname: Anga
authors.forename: János
authors.initials: J
authors.lastname: Sándor
authors.forename: Judit
authors.initials: J
authors.lastname: Megyesi
authors.forename: Dezso
authors.initials: D
authors.lastname: Kelemen
authors.forename: Marcella
authors.initials: M
authors.lastname: Mottolese
authors.forename: Pier Giorgio
authors.initials: PG
authors.lastname: Natali
authors.forename: Géza
authors.initials: G
authors.lastname: Hegedus
authors.forename: István
authors.initials: I
authors.lastname: Arany
authors.forename: Istvan
authors.initials: I
authors.lastname: Ember
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000201:enzymology* / Q000235:genetics / Q000473:pathology*; D051546:Cyclooxygenase 2 / Q000096:biosynthesis; D048049:Extracellular Signal-Regulated MAP Kinases / Q000378:metabolism; D005260:Female; D006801:Humans; D006814:Hungary; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000096:biosynthesis; D008875:Middle Aged; D009367:Neoplasm Staging; D010766:Phosphorylation; D011379:Prognosis; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000235:genetics / Q000378:metabolism; D011960:Receptors, Estrogen / Q000096:biosynthesis; D011980:Receptors, Progesterone / Q000096:biosynthesis
chemical_list: D051546:Cyclooxygenase 2; D048049:Extracellular Signal-Regulated MAP Kinases; D019394:Ki-67 Antigen; D018719:Erb-b2 Receptor Tyrosine Kinases; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone