[Clinical early intervention of Tongxia Huayu Decoction on pancreatic microcirculatory disturbance in severe acute pancreatitis].
OBJECTIVE
To study the mechanisms of Tongxia Huayu Decoction (a Chinese herbal decoction for purgation and removing blood stasis) in prognostic improvement for severe acute pancreatitis by early intervention on pancreatic microcirculatory disturbance.


METHODS
Fifty-three patients with severe acute pancreatitis were divided randomly into treatment group (n=28) and control group (n=25). Tongxia Huayu Decoction was given to the patients in treatment group in addition to the normal treatment in control group for one week. The clinical symptoms and signs, hemodiastase, urinary amylase, C-reactive protein (CRP) and endothelin (ET) of the patients in the two groups before and after treatment were observed and detected.


RESULTS
The total response rate of the treatment group was 98.4%, while that of the control group was 80%, with significant difference between them (P<0.05). There was no significant difference of the contents of hemodiastase, urinary amylase, CRP and ET between the two groups before treatment, while they were significantly decreased after treatment (P<0.01) with more obvious change in treatment group (P<0.01).


CONCLUSIONS
Tongxia Huayu Decoction brings satisfied therapeutic effect on severe acute pancreatitis. The mechanisms may associate with its reducing function on ET releasing so as to inhibit the pancreatic microcirculatory disturbance and acinar cell injury induced by ET.
Fang
Bang-jiang
BJ
Emergency Department, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China.
Gao
Pei-yang
PY
He
Song-hua
SH
Chen
Hao
H
Shen
Ping
P
Zhang
Yi-ying
YY
Zhang
Jing-zhe
JZ
D000328:Adult; D002097:C-Reactive Protein / Q000378:metabolism; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D016232:Endothelins / Q000097:blood; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008833:Microcirculation / Q000187:drug effects; D008875:Middle Aged; D010179:Pancreas / Q000098:blood supply / Q000187:drug effects* / Q000473:pathology; D019283:Pancreatitis, Acute Necrotizing / Q000188:drug therapy* / Q000503:physiopathology; D008517:Phytotherapy; D016896:Treatment Outcome
D004365:Drugs, Chinese Herbal; D016232:Endothelins; C527185:tongxia huayu; D002097:C-Reactive Protein