An unusual vulval lesion in an HIV-infected woman.
This is the case of a black African woman who presented with three distinct episodes of herpes simplex virus (HSV) infection unresponsive to first-line therapy. Clinical and virological resistance to aciclovir therapy was demonstrated, and although the first two episodes manifested as the deep ulceration often associated with HIV/HSV coinfection, the third was an atypical hypertrophic lesion. This is despite her CD4 count being persistently above 300 and there being no previous diagnosis of AIDS.
Boothby
Meg
M
Whittall Street Clinic, Birmingham B4 6DH, UK. meg.boothby@hobtpct.nhs.uk
Radcliffe
Keith
K
D000212:Acyclovir / Q000031:analogs & derivatives / Q000627:therapeutic use; D000293:Adolescent; D044966:Anti-Retroviral Agents / Q000627:therapeutic use; D024882:Drug Resistance, Viral; D005260:Female; D006678:HIV; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D006561:Herpes Simplex / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D011247:Pregnancy; D018139:Simplexvirus; D000077483:Valacyclovir; D014633:Valine / Q000031:analogs & derivatives / Q000627:therapeutic use; D014845:Vulvar Diseases / Q000188:drug therapy / Q000473:pathology / Q000821:virology*
D044966:Anti-Retroviral Agents; D014633:Valine; D000077483:Valacyclovir; D000212:Acyclovir