Heart sensitivity to electrolyte composition of perfusion solution of rats after severe brain injury.
The in vitro model of isovolumic beating heart revealed enhanced sensitivity of the hearts from rats survived severe brain injury to concentration of Ca(2+), Na(+), and H(+) ions in the perfusion solution. Inhibition of myocardial contractile function after trauma was accompanied by destruction signs in cardiomyocyte sarcolemma and mitochondrial dysfunction.
Rusakov
V V
VV
Department of Pathophysiology with Clinical Pathophysiology Course, Omsk State Medical Academy. vvr@omsk-osma.ru
Dolgikh
V T
VT
D000818:Animals; D001786:Blood Glucose; D001794:Blood Pressure / Q000187:drug effects*; D001930:Brain Injuries / Q000503:physiopathology*; D002118:Calcium / Q000494:pharmacology; D004573:Electrolytes / Q000494:pharmacology*; D006863:Hydrogen-Ion Concentration; D019344:Lactic Acid / Q000097:blood; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects* / Q000502:physiology; D010477:Perfusion; D051381:Rats; D017208:Rats, Wistar; D012964:Sodium / Q000494:pharmacology
D001786:Blood Glucose; D004573:Electrolytes; D019344:Lactic Acid; D012964:Sodium; D002118:Calcium