Effects of growth hormone on glucose and fat metabolism in human subjects.
This article focuses on in vivo data from tests performed in normal subjects and in patients who had abnormal growth hormone (GH) status. Experimental data in human subjects demonstrate that GH acutely inhibits glucose disposal in skeletal muscle. At the same time GH stimulates the turnover and oxidation of free fatty acid (FFA), and experimental evidence suggests a causal link between elevated FFA levels and insulin resistance in skeletal muscle. Observational data in GH-deficient adults do not indicate that GH replacement is associated with significant impairment of glucose tolerance, but it is recommended that overdosing be avoided and glycemic control be monitored.
Jørgensen
Jens O L
JO
Medical Department M (Endocrinology and Diabetes) and Institute of Experimental Clinical Research, Aarhus University Hospital, Norrebrogade 44, DK-800C, Aarhus, Denmark. jolj@dadlnet.dk
Møller
Louise
L
Krag
Morten
M
Billestrup
Nils
N
Christiansen
Jens S
JS
D005215:Fasting / Q000378:metabolism; D005947:Glucose / Q000378:metabolism*; D013006:Growth Hormone / Q000494:pharmacology*; D006801:Humans; D007333:Insulin Resistance; D050356:Lipid Metabolism / Q000187:drug effects*; D008954:Models, Biological; D035842:Research Subjects
D013006:Growth Hormone; D005947:Glucose