title: Domino metathesis of 3,6-dihydro-1,2-oxazine: access to isoxazolo[2,3-a]pyridin-7-ones.
abstract: [reaction: see text] Strained bicyclic 3,6-dihydro-1,2-oxazine is a reactive substrate in domino metathesis with an external alkene. This general transformation leads to isoxazolo[2,3-a]pyridin-7-one, a versatile scaffold combining chemical functions that could be selectively oxidized or reduced. The synthetic relevance of these domino metathesis products is demonstrated by a straightforward synthesis of a quinolizinone.
authors.affiliation: Laboratoire de Procédés et Substances Naturelles, Institut de Chimie Moléculaire et des Matériaux d'ORSAY, ICMMO - UMR 8182 - Bâtiment 410 Université Paris-Sud XI, 15 rue Georges Clémenceau, 91405 Orsay Cedex, France.
authors.forename: Géraldine
authors.initials: G
authors.lastname: Calvet
authors.forename: Nicolas
authors.initials: N
authors.lastname: Blanchard
authors.forename: Cyrille
authors.initials: C
authors.lastname: Kouklovsky