Imipenem-resistance in Klebsiella pneumoniae in Malaysia due to loss of OmpK36 outer membrane protein coupled with AmpC hyperproduction.
Palasubramaniam
Selvi
S
Karunakaran
Rina
R
Gin
Gan Gin
GG
Muniandy
Sekaran
S
Parasakthi
Navaratnam
N
D000328:Adult; D000595:Amino Acid Sequence; D001426:Bacterial Proteins / Q000096:biosynthesis* / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D001483:Base Sequence; D024881:Drug Resistance, Bacterial; D005260:Female; D006801:Humans; D015378:Imipenem / Q000494:pharmacology*; D007710:Klebsiella Infections / Q000188:drug therapy / Q000382:microbiology*; D007711:Klebsiella pneumoniae / Q000187:drug effects / Q000235:genetics / Q000302:isolation & purification / Q000378:metabolism*; D008296:Malaysia; D018272:Porins / Q000172:deficiency* / Q000235:genetics / Q000276:immunology; D001618:beta-Lactamases / Q000096:biosynthesis* / Q000172:deficiency / Q000235:genetics / Q000378:metabolism
D001426:Bacterial Proteins; C092233:OmpK36 protein, Klebsiella pneumoniae; D018272:Porins; D015378:Imipenem; C048795:AmpC beta-lactamases; D001618:beta-Lactamases