title: [Experimental study of acute lung injury induced by glutamate in vivo].
abstract: OBJECTIVE
  To investigate the possible injury induced by glutamate in the lung.
  
  
  METHODS
  The lung wet weight/body weight (LW/BW), lung wet/dry weight (W/D), the content of cells and the total protein (TP) in bronchoalveolar lavage fluid (BALF) were determined together with the micromorphology observation.
  
  
  RESULTS
  (1) The LW/BW, W/D, the content of white blood cells, red blood cells and TP in BALF increased in a dose dependent manner 2 hours after the administration of the glutamate (0.50 - 0.75 g/kg). (2) Examination of histological sections showed the presence of lung inflammation charactered by neutrophils recruitment 2 hours after the glutamate administration. (3) The increase of W/D caused by glutamate (0.50 g/kg) was nearly abolished by pre-treatment with MK801 (a specific blocker of NMDA receptor, 0.1 mg/kg) for 30 minutes (P<0.05).
  
  
  CONCLUSIONS
  Glutamate can cause the acute lung injury through the activation of NMDA receptor in vivo.
authors.affiliation: Department of Physiology, Xiangya School of Medicine, Central South University, Changsha 410078, China.
authors.forename: Li
authors.initials: L
authors.lastname: Shen
authors.forename: Zi-Qiang
authors.initials: ZQ
authors.lastname: Luo
authors.forename: Jian-Zhong
authors.initials: JZ
authors.lastname: Han
authors.forename: Shao-Jie
authors.initials: SJ
authors.lastname: Yue
authors.forename: Xiao-Qun
authors.initials: XQ
authors.lastname: Qin
authors.forename: Chen
authors.initials: C
authors.lastname: Li
authors.forename: Hui-Jun
authors.initials: HJ
authors.lastname: Liu
mesh_terms: D000208:Acute Disease; D000818:Animals; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology; D016291:Dizocilpine Maleate / Q000494:pharmacology; D004906:Erythrocyte Count; D018698:Glutamic Acid / Q000008:administration & dosage / Q000633:toxicity*; D007958:Leukocyte Count; D008171:Lung Diseases / Q000139:chemically induced* / Q000378:metabolism / Q000517:prevention & control; D008297:Male; D051379:Mice; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors / Q000378:metabolism
chemical_list: D016194:Receptors, N-Methyl-D-Aspartate; D018698:Glutamic Acid; D016291:Dizocilpine Maleate