Molecular imaging and therapy of atherosclerosis with targeted nanoparticles.
Advances in bionanotechnology are poised to impact the field of cardiovascular diagnosis and therapy for decades to come. This review seeks to illustrate selected examples of newly developed diagnostic and therapeutic nanosystems that have been evaluated in experimental atherosclerosis, thrombosis, and vascular biology. We review a variety of nanotechnologies that are capable of detecting early cardiovascular pathology, as well as associated imaging approaches and conjunctive strategies for site-targeted treatment with nanoparticle delivery systems.
Wickline
Samuel A
SA
Department of Medicine, Washington University, St. Louis, Missouri 63110, USA. saw@wuphys.wustl.edu
Neubauer
Anne M
AM
Winter
Patrick M
PM
Caruthers
Shelton D
SD
Lanza
Gregory M
GM
D050197:Atherosclerosis / Q000175:diagnosis / Q000628:therapy; D003287:Contrast Media; D003952:Diagnostic Imaging / Q000379:methods*; D006801:Humans; D050997:Nanomedicine / Q000379:methods*; D053758:Nanoparticles / Q000627:therapeutic use*; D009389:Neovascularization, Pathologic / Q000175:diagnosis
D003287:Contrast Media