High CSF neurofilament heavy chain levels in neuromyelitis optica.
The neurofilament heavy chain (NfHSMI35), a biomarker of axonal damage in the CSF, was measured in patients with neuromyelitis optica (NMO) and multiple sclerosis (MS). Significantly high CSF NfHSMI35 levels (>0.73 ng/mL) were found in 6 of 24 (25%) of the patients with NMO but none of the patients with MS (0/24). This finding suggests that axonal damage is more severe in NMO than in MS.
Miyazawa
I
I
Department of Neurology, Tohoku University School of Medicine, Seiryo-machi, Aoba-ku, Sendai, Japan.
Nakashima
I
I
Petzold
A
A
Fujihara
K
K
Sato
S
S
Itoyama
Y
Y
D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000134:cerebrospinal fluid; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016900:Neurofilament Proteins / Q000134:cerebrospinal fluid*; D009471:Neuromyelitis Optica / Q000134:cerebrospinal fluid* / Q000175:diagnosis; D012189:Retrospective Studies
D015415:Biomarkers; D016900:Neurofilament Proteins