[Matrix-metalloproteinases and glaucoma].
OBJECTIVE
To analyze the matrix-metalloproteinases' activity (MMP-2 and MMP-9) in primary open angle glaucoma patients with indication for filtrating surgery.


METHODS
A prospective study, 8 months, in the Ophthalmology Department of the Central Military Hospital, with the collaboration of "Victor Babes" Institute. The study was conducted on 27 eyes with primary open glaucoma and that have underwent filtrating surgery. Patients with other ocular or systemic associated conditions were excluded. Patients were distributed in 3 groups, according to their topical treatment with prostaglandin analogs: Group A: 11 eyes with travoprost 0,004%. Group B: 9 eyes with latanoprost 0,005%. Group C: 7 eyes without prostaglandin analogs. The fragments collected during surgery were processed for imunohistochimical analysis for MMPs. It has used the indirect tristadial method: streptavidine-biotin-peroxidase.
Malcea
Cristina
C
Secţia Clinică de Oftalmologie, Spitalul clinic de Urgentă Militar Central.
Stefan
Cornel
C
D000959:Antihypertensive Agents / Q000008:administration & dosage*; D003008:Cloprostenol / Q000008:administration & dosage / Q000031:analogs & derivatives*; D004359:Drug Therapy, Combination; D005902:Glaucoma, Open-Angle / Q000188:drug therapy* / Q000201:enzymology* / Q000601:surgery; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D000077338:Latanoprost; D020778:Matrix Metalloproteinase 2 / Q000187:drug effects / Q000378:metabolism*; D020780:Matrix Metalloproteinase 9 / Q000187:drug effects / Q000378:metabolism*; D020782:Matrix Metalloproteinases / Q000378:metabolism; D009883:Ophthalmic Solutions / Q000008:administration & dosage; D011446:Prospective Studies; D011461:Prostaglandins F, Synthetic / Q000008:administration & dosage*; D014130:Trabeculectomy; D000069557:Travoprost
D000959:Antihypertensive Agents; D009883:Ophthalmic Solutions; D011461:Prostaglandins F, Synthetic; D003008:Cloprostenol; D000077338:Latanoprost; D020782:Matrix Metalloproteinases; D020778:Matrix Metalloproteinase 2; D020780:Matrix Metalloproteinase 9; D000069557:Travoprost