Contractile effect of the aqueous extract of Psidium guajava leaves on aortic rings in rat.
Aqueous leaves extract of Psidium guajava significantly and dose-dependently (0.25-2 mg/ml) contracted aorta rings. The effect was evaluated also in presence of nifedipine and phentolamine. The sensitivity of the aortic rings to cumulative doses of P. guajava was significantly enhanced in the presence of phentolamine suggesting that the effect of P. guajava was to a large extent mediated by activation of alpha-adrenoceptor and to a lesser extent by acting via calcium ion channel.
Olatunji-Bello
I I
II
Department of Physiology, College of Medicine, University of Lagos, Idi-Araba, Lagos, Nigeria. yemi2bello@yahoo.com
Odusanya
A J
AJ
Raji
I
I
Ladipo
C O
CO
D000818:Animals; D001011:Aorta / Q000187:drug effects; D009119:Muscle Contraction / Q000187:drug effects*; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018515:Plant Leaves; D031647:Psidium; D051381:Rats; D017207:Rats, Sprague-Dawley; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use
D010936:Plant Extracts; D014665:Vasodilator Agents