title: Acute life threatening event (ALTE) in an infant with human coronavirus HCoV-229E infection.
abstract: In this short report we discuss the temporal association between an acute life threatening event (ALTE) and a RT-PCR confirmed coronavirus HCoV-229E infection in a 4 months old otherwise healthy infant. More detailed microbiological investigations of affected children even without apparent signs of a respiratory tract infection may help to clarify the etiology in some patients and extend our understanding of the pathogenesis. PCR-based techniques should be utilized to increase the sensitivity of detection for old and new respiratory viral pathogens in comparable cases.
authors.affiliation: Children's Hospital Medical Centre, University of Bonn, Bonn, Germany. asimon@ukb.uni-bonn.de
authors.forename: Arne
authors.initials: A
authors.lastname: Simon
authors.forename: Sebastian
authors.initials: S
authors.lastname: Völz
authors.forename: Katja
authors.initials: K
authors.lastname: Höfling
authors.forename: Alexandra
authors.initials: A
authors.lastname: Kehl
authors.forename: Ramona
authors.initials: R
authors.lastname: Tillman
authors.forename: Andreas
authors.initials: A
authors.lastname: Müller
authors.forename: Bernd
authors.initials: B
authors.lastname: Kupfer
authors.forename: Anna-Maria
authors.initials: AM
authors.lastname: Eis-Hübinger
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Lentze
authors.forename: Udo
authors.initials: U
authors.lastname: Bode
authors.forename: Oliver
authors.initials: O
authors.lastname: Schildgen
mesh_terms: D001049:Apnea / Q000209:etiology*; D001919:Bradycardia / Q000209:etiology*; D028941:Coronavirus 229E, Human / Q000235:genetics / Q000302:isolation & purification; D018352:Coronavirus Infections / Q000175:diagnosis*; D016638:Critical Illness; D004279:DNA, Viral / Q000302:isolation & purification; D005260:Female; D006801:Humans; D007223:Infant; D020133:Reverse Transcriptase Polymerase Chain Reaction
chemical_list: D004279:DNA, Viral