title: Simultaneous complication of multiple myeloma with Sjögren syndrome.
abstract: We report a 72-year-old female case of IgG-kappa type multiple myeloma (MM) simultaneously complicated with Sjögren syndrome (SS). She also presented marked hyperamylasemia of salivary-type isozyme. Although she had received sequential chemotherapy completed with high-dose therapy with autologous hematopoietic stem cell transplantation, she died of relapse fifteen months after the initial diagnosis. Various autoantibodies indicated that her sicca symptoms were due to true SS and not caused by MM cell infiltration to exocrine glands. MM cells appeared to produce amylase that fluctuated correspondingly to the disease status of MM. To our knowledge, this is the first English report of simultaneous complication of SS and MM referring to hyperamylasemia. Accumulation of this rare clinical manifestation is important to elucidate the pathogenesis of MM under condition of immunological disorder caused by SS.
authors.affiliation: Department of Hematology, Aiseikai-Yamashina Hospital, Kyoto Prefectural University of Medicine, Yamashina-ku, Japan. aiseikai@mbox.kyoto-inet.or.jp
authors.forename: Hiroto
authors.initials: H
authors.lastname: Kaneko
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Ohkawara
authors.forename: Kouichi
authors.initials: K
authors.lastname: Taniguchi
authors.forename: Yousuke
authors.initials: Y
authors.lastname: Matsumoto
authors.forename: Kenichi
authors.initials: K
authors.lastname: Nomura
authors.forename: Shigeo
authors.initials: S
authors.lastname: Horiike
authors.forename: Shouhei
authors.initials: S
authors.lastname: Yokota
authors.forename: Masafumi
authors.initials: M
authors.lastname: Taniwaki
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D034321:Hyperamylasemia / Q000097:blood / Q000150:complications / Q000175:diagnosis / Q000628:therapy; D007145:Immunoglobulin kappa-Chains / Q000097:blood; D009101:Multiple Myeloma / Q000097:blood / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D036102:Peripheral Blood Stem Cell Transplantation; D012859:Sjogren's Syndrome / Q000097:blood / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D014182:Transplantation, Autologous
chemical_list: D007145:Immunoglobulin kappa-Chains