Autonomous thyroid nodule in an adolescent 10 years after total body irradiation for bone marrow transplant.
A male patient with B-cell lymphoma was treated with chemotherapy and allogeneic bone marrow transplant, including preparatory total body irradiation. Ten years later, at age 15 years, the patient developed an autonomous thyroid nodule and an incidental papillary microcarcinoma. This is the first report of an autonomous thyroid nodule after total body irradiation for bone marrow transplant. The case is presented and the literature is reviewed.
Jetha
Mary M
MM
Department of Pediatrics, Division of Endocrinology and Rheumatology, University of Alberta Hospital and Stollery Children's Hospital, Edmonton, Alberta, Canada.
Stobart
Kent
K
Lees
Gordon M
GM
Couch
Robert M
RM
D000236:Adenoma / Q000175:diagnosis* / Q000628:therapy; D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D044963:Biopsy, Fine-Needle / Q000379:methods; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D002291:Carcinoma, Papillary / Q000175:diagnosis* / Q000628:therapy; D005500:Follow-Up Studies; D006801:Humans; D016393:Lymphoma, B-Cell / Q000628:therapy*; D008297:Male; D016609:Neoplasms, Second Primary; D016606:Thyroid Nodule / Q000175:diagnosis* / Q000628:therapy; D014184:Transplantation, Homologous; D016896:Treatment Outcome; D014916:Whole-Body Irradiation / Q000009:adverse effects*