title: Contact allergy to topical medicaments becomes more common with advancing age: an age-stratified study.
abstract: Eczema is common in the elderly people who often use topical medicaments. Previous studies in the elderly people have noted allergic positive patch tests in between 43% and 64% of those tested. We set out to assess whether medicament contact allergies are more common in elderly patients. We undertook a retrospective age-stratified study of all patients patch tested at the Royal Hallamshire Hospital, Sheffield, between January 1994 and July 2005. We confirmed that contact allergy to topical medicaments is more common in those aged more than 70 years compared with the younger age groups. There was no sex difference. The commonest problematic allergen types found in medicaments were fragrances and preservatives. The most frequent individual allergens were fragrance mix, Myroxylon pereirae, lanolins, local anaesthetic agents, neomycin and gentamicin, and tixocortol pivolate. The pattern of medicament contact allergens was similar to that of the younger age groups except that multiple allergic positives were more frequent and sensitivities to local anaesthetics and Myroxylon pereirae were proportionally more common. Elderly patients were more likely to have multiple contact allergies than the younger ones. Care needs to be taken when prescribing topical medicaments to elderly patients with eczema, especially for preparations that contain perfumes, lanolins, and local anaesthetics.
authors.affiliation: Department of Dermatology, Royal Hallamshire Hospital, Sheffield S10 2JF, UK.
authors.forename: Carl M
authors.initials: CM
authors.lastname: Green
authors.forename: Catherine R
authors.initials: CR
authors.lastname: Holden
authors.forename: David J
authors.initials: DJ
authors.lastname: Gawkrodger
mesh_terms: D000287:Administration, Topical; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology; D000328:Adult; D000367:Age Factors; D000368:Aged; D000779:Anesthetics, Local / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology; D016009:Chi-Square Distribution; D017449:Dermatitis, Allergic Contact / Q000209:etiology*; D005260:Female; D006801:Humans; D007809:Lanolin / Q000008:administration & dosage / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D009824:Ointments / Q000008:administration & dosage / Q000009:adverse effects; D010328:Patch Tests; D010476:Perfume / Q000008:administration & dosage / Q000009:adverse effects; D012189:Retrospective Studies
chemical_list: D000305:Adrenal Cortex Hormones; D000779:Anesthetics, Local; D000890:Anti-Infective Agents; D009824:Ointments; D010476:Perfume; D007809:Lanolin