title: Treatment of chronic hepatitis B or C in HIV-infected patients with dual viral hepatitis.
abstract: Dual chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infections are recognized in 3%-5% of human immunodeficiency virus (HIV)-infected individuals. More severe liver disease is seen in these patients. Viral interference may account for the fact that replication of one virus generally predominates over replication of the other. The impact that treatment of HBV or HCV infection has on this reciprocal inhibition is not well established. No evidence of reactivation of either HBV or HCV was seen when complete suppression of the other predominant virus was achieved with specific therapy in 21 subjects with HIV infection and dual HBV/HCV infections. This information has important pathogenic implications and may influence therapeutic decisions.
authors.affiliation: Department of Infectious Diseases, Hospital Carlos III, Madrid, 28029, Spain. vsoriano@dragonet.es
authors.forename: Vincent
authors.initials: V
authors.lastname: Soriano
authors.forename: Pablo
authors.initials: P
authors.lastname: Barreiro
authors.forename: Luz
authors.initials: L
authors.lastname: Martín-Carbonero
authors.forename: Carol
authors.initials: C
authors.lastname: Castellares
authors.forename: Andres
authors.initials: A
authors.lastname: Ruiz-Sancho
authors.forename: Pablo
authors.initials: P
authors.lastname: Labarga
authors.forename: Belen
authors.initials: B
authors.lastname: Ramos
authors.forename: Juan
authors.initials: J
authors.lastname: Gonzalez-Lahoz
mesh_terms: D000328:Adult; D000998:Antiviral Agents / Q000494:pharmacology / Q000627:therapeutic use*; D004279:DNA, Viral / Q000097:blood; D005260:Female; D015658:HIV Infections / Q000150:complications*; D016174:Hepacivirus / Q000187:drug effects / Q000235:genetics / Q000276:immunology; D006510:Hepatitis B Antibodies / Q000097:blood; D006515:Hepatitis B virus / Q000187:drug effects / Q000235:genetics / Q000276:immunology; D019694:Hepatitis B, Chronic / Q000150:complications* / Q000188:drug therapy*; D018937:Hepatitis C Antibodies / Q000097:blood; D019698:Hepatitis C, Chronic / Q000150:complications* / Q000188:drug therapy*; D006801:Humans; D008297:Male; D012367:RNA, Viral / Q000097:blood; D014762:Viral Interference
chemical_list: D000998:Antiviral Agents; D004279:DNA, Viral; D006510:Hepatitis B Antibodies; D018937:Hepatitis C Antibodies; D012367:RNA, Viral