[Aminochlorthenoxycycline levels in experimental acute inflammation of the respiratory tree].
A special technique used to obtain acute respiratory inflammation in the rabbit produced a considerable increase in expectorate by comparison with the controls. Bronchial, lung and blood aminochlorthenoxycycline levels were much higher than in the controls, showing that this antibiotic has a marked affinity for inflamed lung tissue.
Rognoni
F
F
Istituto Chemioterapico Italiano (San Grato di Lodi).
Ariano
M
M
Lucca
L
L
D000171:Acrolein / Q000008:administration & dosage / Q000633:toxicity; D000208:Acute Disease; D000280:Administration, Inhalation; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000032:analysis / Q000493:pharmacokinetics*; D048588:Benzoxazines; D001991:Bronchitis / Q000139:chemically induced / Q000378:metabolism / Q000473:pathology; D004353:Drug Evaluation, Preclinical; D005122:Exudates and Transudates / Q000737:chemistry; D007249:Inflammation / Q000139:chemically induced / Q000378:metabolism; D007273:Injections, Intramuscular; D008168:Lung / Q000737:chemistry; D010078:Oxazines / Q000008:administration & dosage / Q000032:analysis / Q000493:pharmacokinetics*; D011014:Pneumonia / Q000139:chemically induced / Q000378:metabolism / Q000473:pathology; D011817:Rabbits; D012140:Respiratory Tract Diseases / Q000139:chemically induced / Q000378:metabolism / Q000473:pathology*
D000900:Anti-Bacterial Agents; D048588:Benzoxazines; D010078:Oxazines; C002856:aminochlorthenoxazine; D000171:Acrolein