How do you treat bleeding disorders with desmopressin?
Desmopressin is an analog of vasopressin that exerts a substantial haemostatic effect by inducing the release of von Willebrand factor from its storage sites in endothelial cells. It has proved useful in treating or preventing bleeding episodes in patients with von Willebrand disease, haemophilia A and platelet function defects. Its efficacy in achieving a satisfactory level of haemostasis has reduced the use of blood products to treat bleeding episodes. Clinicians need to become familiar with the use of this drug that has become a home medication for many patients with inherited bleeding disorders.
Ozgönenel
Bülent
B
Carman and Ann Adam's Department of Pediatrics, Division of Hematology/Oncology, Children's Hospital of Michigan, Wayne State University, Detroit, Michigan 48201-2196, USA. bulentozgonenel@yahoo.com
Rajpurkar
Madhvi
M
Lusher
Jeanne M
JM
D003894:Deamino Arginine Vasopressin / Q000008:administration & dosage* / Q000009:adverse effects / Q000494:pharmacology; D004333:Drug Administration Routes; D006474:Hemorrhagic Disorders / Q000188:drug therapy*; D006490:Hemostatics / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology; D006801:Humans; D014841:von Willebrand Factor / Q000502:physiology
D006490:Hemostatics; D014841:von Willebrand Factor; D003894:Deamino Arginine Vasopressin