An approach to the antiinflammatory activity of borjatriol.
The antiinflammatory activity of borjatriol (a diterpenoid isolated from SIDERITIS MUGRONENSIS Borja) was tested using the cotton pellet-granuloma assay. The compound inhibited the granuloma weight and the serum lysozyme activity in a dose-dependently way. The determination of this enzyme has allowed us to distinguish between an irritant (carrageenan) which reduces the granuloma weight and antiinflammatory substances (phenylbutazone and borjatriol).
Villar
A
A
Departamento de Farmacognosia y Farmacodinamia, Facultad de Farmacia, Valencia, Spain.
Salom
R
R
Alcaraz
M J
MJ