title: Is cystatin C useful for the detection and the estimation of low glomerular filtration rate in heart transplant patients?
abstract: Although previously studied in patients with chronic kidney disease, there is less data for the use of cystatin C and cystatin C-based formulas in heart transplant recipients. The ability of creatinine and cystatin C to detect renal failure (glomerular filtration rate [GFR] below 60 mL/min/1.73 m(2)) in heart transplant patients has been compared. The accuracy and precision of a creatinine-based formula (Modification of Diet in Renal Disease [MDRD]) versus a cystatin C-based formula (Rule's formula) to estimate GFR have also been studied. GFR was measured using the (51)Cr-ethylenediamine tetraacetic acid tracer in 27 patients. There was no significant difference between GFR and the reciprocal of creatinine or cystatin C. Receiver operating characteristic curves for cystatin C and creatinine were similar. Both formulas were well correlated with the GFR. The bias of the cystatin C-based was significantly better than one of the MDRD formula, but the standard deviation appeared better for the MDRD formula (bias of +3.9 mL/min/1.73 m(2) versus +12 mL/min/1.73 m(2) and SD of 8.5 versus 11.6, respectively). Plasma cystatin C has no clear advantage over serum creatinine to detect renal failure in heart transplanted patients.
authors.affiliation: Department of Nephrology, University of Liège, CHU, Sart Tilman, Liège, Belgium. pierre_delanaye@yahoo.fr
authors.forename: Pierre
authors.initials: P
authors.lastname: Delanaye
authors.forename: Eric
authors.initials: E
authors.lastname: Nellessen
authors.forename: Etienne
authors.initials: E
authors.lastname: Cavalier
authors.forename: Gisèle
authors.initials: G
authors.lastname: Depas
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Grosch
authors.forename: Jean-Olivier
authors.initials: JO
authors.lastname: Defraigne
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Chapelle
authors.forename: Jean-Marie
authors.initials: JM
authors.lastname: Krzesinski
authors.forename: Patrizio
authors.initials: P
authors.lastname: Lancellotti
mesh_terms: D015415:Biomarkers / Q000097:blood; D003404:Creatinine / Q000097:blood; D055316:Cystatin C; D015891:Cystatins / Q000097:blood*; D005260:Female; D005919:Glomerular Filtration Rate; D016027:Heart Transplantation / Q000009:adverse effects* / Q000502:physiology*; D006801:Humans; D008107:Liver Diseases / Q000097:blood / Q000209:etiology; D008297:Male
chemical_list: D015415:Biomarkers; C525030:CST3 protein, human; D055316:Cystatin C; D015891:Cystatins; D003404:Creatinine