title: Successful management of an extensive intracranial sinus thrombosis in a patient undergoing IVF: case report and review of literature.
abstract: OBJECTIVE
  To report a successfully managed case of extensive intracranial sinus thrombosis that occurred during an IVF cycle, and to review the literature.
  
  
  METHODS
  Case report and review of literature.
  
  
  METHODS
  University-affiliated teaching hospital.
  
  
  METHODS
  A 38-year-old nulliparous woman who developed severe ovarian hyperstimulation syndrome on luteal day (LD) 5 during an IVF cycle. Hemoconcentration was corrected, ascitis drained, and heparin prophylaxis started. On LD7, the patient complained of severe headache and neck pain. A magnetic resonance imaging (MRI) study of the head showed extensive cortical vein and dural sinus thrombosis, including the superior sagittal sinus and transverse sinuses.
  
  
  METHODS
  The patient was fully heparinized using low-molecular-weight heparin. On LD15 she was discharged home on warfarin, after confirming a negative pregnancy test. Complete thrombophilia work-up was negative.
  
  
  METHODS
  Clinical outcome.
  
  
  RESULTS
  Repeat MRI 2 months later revealed patent superior sagittal sinus and transverse sinuses, unremarkable cortical veins, and no evidence of flow obstruction. The patient was asymptomatic, with no neurologic sequelae.
  
  
  CONCLUSIONS
  Extensive intracranial sinus thrombosis in women undergoing IVF may present with minimal symptoms and can occur in the absence of pregnancy and thrombophilia and despite heparin prophylaxis and correction of hemoconcentration. Medical management was successful and left the patient with no neurologic sequelae.
authors.affiliation: Department of Obstetrics and Gynecology, University of Western Ontario, London, Ontario, Canada. fawazedris@yahoo.ca <fawazedris@yahoo.ca>
authors.forename: Fawaz
authors.initials: F
authors.lastname: Edris
authors.forename: Cecelia M
authors.initials: CM
authors.lastname: Kerner
authors.forename: Valter
authors.initials: V
authors.lastname: Feyles
authors.forename: Andrew
authors.initials: A
authors.lastname: Leung
authors.forename: Stephen
authors.initials: S
authors.lastname: Power
mesh_terms: D000328:Adult; D000925:Anticoagulants / Q000627:therapeutic use; D005260:Female; D005307:Fertilization in Vitro; D006495:Heparin, Low-Molecular-Weight / Q000627:therapeutic use; D006801:Humans; D020767:Intracranial Thrombosis / Q000188:drug therapy* / Q000473:pathology; D008279:Magnetic Resonance Imaging; D016896:Treatment Outcome
chemical_list: D000925:Anticoagulants; D006495:Heparin, Low-Molecular-Weight