[Diterpenes and other components of Croton hirtus (Euphorbiaceae)].
The roots of Croton hirtus (Euphorbiaceae) collected in Paraiso, Cartago (Costa Rica) afforded, in addition to the few known metabolites, 20 new compounds: the bis-nor dolabradane 1, the dolabradanes 2 and 3, the kauranes 4-7, the cyclopropakauranes 8 and 9, the hirtusanes 10-15, the germacradiene esters 16-18 and the C-25 compound 21, presumably formed by a Diels-Alder reaction between compound 18 and a monoterpene. All structures were elucidated using high field 1D and 2D NMR techniques. MS fragmentation patterns are here reported. The absolute configurations of 4 and 9 were elucidated by using circular dichroism. The separation was performed with modern chromatographic technics.
Fuentes
J C
JC
Escuela de Química y Centro de Investigación de Productos Naturales, Universidad de Costa Rica, San José, Costa Rica. renato@calzada.equi.ucr.ac.cr
Castro
V
V
Jakupovic
J
J
Murillo
R
R
D002851:Chromatography, High Pressure Liquid; D029802:Croton / Q000737:chemistry*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification*; D010936:Plant Extracts / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry*
D004224:Diterpenes; D010936:Plant Extracts