title: Artemisinins inhibit Trypanosoma cruzi and Trypanosoma brucei rhodesiense in vitro growth.
abstract: Artemisinin compounds inhibit in vitro growth of cultured Trypanosoma cruzi and Trypanosoma brucei rhodesiense at concentrations in the low micromolar range. Artemisinin also inhibits calcium-dependent ATPase activity in T. cruzi membranes, suggesting a mode of action via membrane pumps. Artemisinins merit further investigation as chemotherapeutic options for these pathogens.
authors.affiliation: Department of Microbiology, University of Mississippi Medical Center, Jackson, MI 39216, USA.
authors.forename: Yuliya V
authors.initials: YV
authors.lastname: Mishina
authors.forename: Sanjeev
authors.initials: S
authors.lastname: Krishna
authors.forename: Richard K
authors.initials: RK
authors.lastname: Haynes
authors.forename: John C
authors.initials: JC
authors.lastname: Meade
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology*; D037621:Artemisinins / Q000494:pharmacology*; D000252:Calcium-Transporting ATPases / Q000037:antagonists & inhibitors; D021261:Parasitic Sensitivity Tests; D012717:Sesquiterpenes / Q000494:pharmacology*; D016833:Trypanosoma brucei rhodesiense / Q000187:drug effects* / Q000254:growth & development; D014349:Trypanosoma cruzi / Q000187:drug effects* / Q000254:growth & development
chemical_list: D000890:Anti-Infective Agents; D037621:Artemisinins; D012717:Sesquiterpenes; C031327:artemisinin; D000252:Calcium-Transporting ATPases