title: Regional radiotherapy may improve outcomes in patients with early stage breast cancer undergoing breast conservation therapy.
abstract: BACKGROUND
  Breast conservation therapy (BCT) is recommended as standard management of early breast cancer. The aim of this study was to retrospectively evaluate the results of BCT to identify prognostic factors predictive of treatment outcomes.
  
  
  METHODS
  Four hundred and ninety-eight eligible women with unilateral stage I-II breast cancer who had undergone BCT were analyzed.
  
  
  RESULTS
  The cumulative incidence of local recurrence (LR) was 1.9% and 3.7% at 3- and 5-years respectively. The 5-year disease-free, cancer-specific, and overall survival (DFS, CSS, OS) were 80.0%, 87.3% and 85.4% respectively. Significant independent predictors for LR included young age and absence of chemotherapy. Regional nodal radiotherapy was significantly associated with improved DFS and OS.
  
  
  CONCLUSIONS
  Our results confirmed the efficacy of BCT in the treatment of early breast cancer and indicated that inclusion of regional nodal areas within the radiotherapy field might be beneficial in the BCT setting, particularly for patients with adverse risk features.
authors.affiliation: Department of Radiation Oncology, Princess Alexandra Hospital, Brisbane, QLD 4102.
authors.forename: G T
authors.initials: GT
authors.lastname: Mai
authors.forename: E
authors.initials: E
authors.lastname: Choo
authors.forename: J L
authors.initials: JL
authors.lastname: Yang
authors.forename: B
authors.initials: B
authors.lastname: Cooke
authors.forename: D
authors.initials: D
authors.lastname: Dumitru
authors.forename: D
authors.initials: D
authors.lastname: Lonergan
authors.forename: C R
authors.initials: CR
authors.lastname: Lewis
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008297:Male; D015412:Mastectomy, Segmental; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D011379:Prognosis; D018714:Radiotherapy, Adjuvant; D012189:Retrospective Studies; D016019:Survival Analysis; D016896:Treatment Outcome