Haptoglobin polymorphisms are associated with Crohn's disease, disease behavior, and extraintestinal manifestations in Hungarian patients.
Functional differences and association with inflammatory disorders were found relating to three major haptoglobin (Hp) phenotypes. Our aim was to investigate Hp polymorphisms in Hungarian patients with Crohn's disease (CD). Four hundred sixty-eight CD patients and 384 healthy controls were examined. Hp phenotypes were determined by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and immunoblotting of the sera. The frequency of the Hp(1) allele was significantly higher in CD (0.395; OR, 1.24; 95% CI, 1.02-1.52; P=0.03) compared to controls (0.345). In CD, Hp phenotype was associated with disease behavior (OR [Hp(2-1) vs other], 2.06; 95% CI, 1.29-3.28 for inflammatory behavior). Furthermore, an increased frequency of primary sclerosing cholangitis was observed in the Hp 2-2 compared to the Hp 1-1 phenotype (6.5% vs. 0.0%; P=0.039). We conclude that the Hp polymorphism is associated with CD, inflammatory disease behavior, and primary sclerosing cholangitis in Hungarian patients. Further studies are required to evaluate the significance of Hp polymorphisms in other populations from geographically diverse regions.
Papp
Maria
M
Department of Gastroenterology, University of Debrecen, Nagyerdei krt. 98, H-4012, Debrecen, Hungary. drpappm@yahoo.com
Lakatos
Peter Laszlo
PL
Palatka
Karoly
K
Foldi
Ildiko
I
Udvardy
Miklos
M
Harsfalvi
Jolan
J
Tornai
Istvan
I
Vitalis
Zsuzsanna
Z
Dinya
Tamas
T
Kovacs
Agota
A
Molnar
Tamas
T
Demeter
Pal
P
Papp
Janos
J
Lakatos
Laszlo
L
Altorjay
Istvan
I
D000328:Adult; D016022:Case-Control Studies; D015209:Cholangitis, Sclerosing / Q000235:genetics* / Q000503:physiopathology; D003424:Crohn Disease / Q000150:complications / Q000235:genetics* / Q000503:physiopathology; D018450:Disease Progression; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006242:Haptoglobins / Q000235:genetics*; D006801:Humans; D006814:Hungary; D015212:Inflammatory Bowel Diseases / Q000150:complications / Q000235:genetics* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010641:Phenotype; D011110:Polymorphism, Genetic; D018570:Risk Assessment
D006242:Haptoglobins