Controlled natural cycle IVF: experience in a world of stimulation.
A total of 134 controlled natural IVF (nIVF) cycles were reviewed retrospectively and compared with 370 stimulated IVF (sIVF) cycles. The clinical pregnancy rate per embryo transfer following nIVF was 27% and 47% in sIVF cycles for patients aged less than 35. However, natural cycle patients could attempt consecutive cycles with much less impact on their lives, both medically and financially. In patients under 35 years of age, the choice of controlled nIVF reduces the cost and risk to the patient, permitting her to have multiple, consecutive attempts, and cumulatively offers a clinical pregnancy rate which approaches that of sIVF. The multiple pregnancy rate in nIVF is significantly reduced compared with sIVF treatment cycles. In patients over 35 years of age the benefits of nIVF were much less evident (clinical pregnancy rate: 8% per embryo transfer) and the opportunity to transfer multiple embryos in these patients seems to be advantageous.
Phillips
Simon J
SJ
OVO Fertility Clinic, 8000 boulevard Décarie, Montréal, Québec, Canada H4P 2S4. s.phillips@cliniqueovo.com
Kadoch
Isaac Jacques
IJ
Lapensée
Louise
L
Couturier
Bernard
B
Hemmings
Robert
R
Bissonnette
François
F
D000328:Adult; D006063:Chorionic Gonadotropin / Q000378:metabolism; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D006801:Humans; D007246:Infertility / Q000628:therapy*; D008297:Male; D008597:Menstrual Cycle; D009865:Oocytes / Q000378:metabolism; D010062:Ovulation Induction; D011247:Pregnancy; D018873:Pregnancy Rate; D013997:Time Factors; D016896:Treatment Outcome
D006063:Chorionic Gonadotropin