Concordance between epidermal nerve fiber density and sensory examination in patients with symptoms of idiopathic small fiber neuropathy.
Quantitation of epidermal nerve fiber (ENF) density is an objective diagnostic test of small fiber neuropathy (SFN). For a diagnostic test to be clinically useful it should correspond well with clinically meaningful physical findings. We performed a retrospective analysis of the concordance between foot ENF density and clinical findings in all patients seen at our institution with possible idiopathic SFN who underwent skin biopsy for ENF density determination. We found a high concordance between reduced foot ENF density and loss of pinprick sensitivity in this patient population. Our findings indicate that ENF density determination is a clinically relevant objective test in patients undergoing evaluation for possible SFN.
Walk
David
D
Department of Neurology, University of Minnesota, Minneapolis 55455, United States. walkx001@umn.edu
Wendelschafer-Crabb
Gwen
G
Davey
Cynthia
C
Kennedy
William R
WR
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D004817:Epidermis / Q000294:innervation / Q000473:pathology* / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D036421:Nerve Fibers, Unmyelinated / Q000473:pathology; D009619:Nociceptors / Q000473:pathology / Q000503:physiopathology; D010146:Pain / Q000175:diagnosis / Q000503:physiopathology; D017288:Pain Threshold / Q000502:physiology; D010523:Peripheral Nervous System Diseases / Q000175:diagnosis* / Q000503:physiopathology; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D011984:Sensory Receptor Cells / Q000473:pathology* / Q000503:physiopathology; D020886:Somatosensory Disorders / Q000175:diagnosis* / Q000503:physiopathology