Donor lymphocyte infusion for the treatment of leukemia relapse after HLA-mismatched/haploidentical T-cell-replete hematopoietic stem cell transplantation.
In this study, we tested the efficacy and safety of donor lymphocyte infusion (DLI) with granulocyte colony-stimulating factor (G-CSF) priming in patients who relapsed after haploidentical hematopoietic stem cell transplantation (HSCT). Twenty patients received DLI at a median of 177 days after HSCT. Eight patients survived in complete remission for a median of 1118 days. The 2-year probability of leukemia-free survival was 40%. Acute graft-versus-host disease (GVHD) grade 3-4 occurred in six patients after DLI. GVHD prophylaxis reduced the incidence of acute GVHD. Our primary data showed that G-CSF-primed DLI with GVHD prophylaxis was a potentially effective therapeutic option for patients who relapsed after haploidentical HSCT.
Huang
Xiao-Jun
XJ
Institute of Hematology, People's Hospital, Peking University, Beijing, China. xjhrm@medmail.com.cn
Liu
Dai-Hong
DH
Liu
Kai-Yan
KY
Xu
Lan-Ping
LP
Chen
Huan
H
Han
Wei
W
D000293:Adolescent; D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001549:Benzamides; D002648:Child; D003131:Combined Modality Therapy; D003561:Cytarabine / Q000008:administration & dosage; D003630:Daunorubicin / Q000008:administration & dosage; D018572:Disease-Free Survival; D005047:Etoposide / Q000627:therapeutic use; D005260:Female; D006086:Graft vs Host Disease / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control; D020544:Graft vs Leukemia Effect; D006680:HLA Antigens / Q000235:genetics; D006239:Haplotypes / Q000235:genetics; D006648:Histocompatibility; D006801:Humans; D000068877:Imatinib Mesylate; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000627:therapeutic use; D053208:Kaplan-Meier Estimate; D007938:Leukemia / Q000188:drug therapy / Q000601:surgery*; D017710:Lymphocyte Transfusion / Q000009:adverse effects; D008297:Male; D008727:Methotrexate / Q000627:therapeutic use; D008942:Mitoxantrone / Q000627:therapeutic use; D010198:Pancytopenia / Q000453:epidemiology / Q000209:etiology; D036102:Peripheral Blood Stem Cell Transplantation; D010879:Piperazines / Q000627:therapeutic use; D011743:Pyrimidines / Q000627:therapeutic use; D012008:Recurrence; D012074:Remission Induction; D016879:Salvage Therapy; D014019:Tissue Donors; D016896:Treatment Outcome
D000970:Antineoplastic Agents; D001549:Benzamides; D006680:HLA Antigens; D007166:Immunosuppressive Agents; D010879:Piperazines; D011743:Pyrimidines; D003561:Cytarabine; D005047:Etoposide; D000068877:Imatinib Mesylate; D008942:Mitoxantrone; D008727:Methotrexate; D003630:Daunorubicin