Anti-influenza A virus activities of mannan-binding lectins and bovine conglutinin.
Mannan-binding lectin (MBL) and bovine conglutinin (BKg) belong to the collectin family, which is involved in first-line host defense against various infectious agents. We have previously reported that human MBL inhibited type A influenza viral hemagglutination, infection and spreading to adjacent cells without complement activation. In this study, we investigated the direct antiviral activities of bovine MBL, rabbit MBL and BKg. All collectins used in this study inhibited viral infectivity and hemagglutination at concentrations of 0.02-0.3 microg/ml. They also demonstrated inhibitory activity against viral spreading. Like human MBL, bovine MBL and BKg showed antiviral activities at their physiological concentrations. These results suggest that mammalian MBLs and BKg may inhibit the spread of influenza A virus through the bloodstream.
Kawai
Takao
T
Department of Infectious Diseases, Osaka Prefectural Institute of Public Health, Japan.
Kase
Tetsuo
T
Suzuki
Yasuhiko
Y
Eda
Souji
S
Sakamoto
Takashi
T
Ohtani
Katsuki
K
Wakamiya
Nobutaka
N
D000818:Animals; D002417:Cattle; D002460:Cell Line; D037222:Collectins / Q000494:pharmacology*; D004285:Dogs; D006385:Hemagglutination Inhibition Tests; D006801:Humans; D053122:Influenza A Virus, H3N2 Subtype / Q000254:growth & development*; D007251:Influenza, Human / Q000188:drug therapy* / Q000378:metabolism / Q000821:virology; D037601:Mannose-Binding Lectin / Q000494:pharmacology*; D011817:Rabbits; D012712:Serum Globulins / Q000494:pharmacology*
D037222:Collectins; D037601:Mannose-Binding Lectin; D012712:Serum Globulins; C024014:conglutinin