Phosphonoxins: rational design and discovery of a potent nucleotide anti-Giardia agent.
Phosphonoxins, a new class of synthetic, rationally designed anti-microbial agents, are described. From this class a sub-micromolar inhibitor of Giardia trophozoite growth has been identified.
Suk
Dae-Hwan
DH
Center for Drug Design, Academic Health Center, University of Minnesota, Minneapolis, MN 55455, USA.
Rejman
Dominik
D
Dykstra
Christine C
CC
Pohl
Radek
R
Pankiewicz
Krzysztof W
KW
Patterson
Steven E
SE
D000818:Animals; D000981:Antiprotozoal Agents / Q000737:chemistry / Q000494:pharmacology*; D015195:Drug Design; D005872:Giardia / Q000187:drug effects*; D006801:Humans; D015394:Molecular Structure; D009711:Nucleotides / Q000737:chemistry / Q000494:pharmacology*; D063065:Organophosphonates / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D000981:Antiprotozoal Agents; D009711:Nucleotides; D063065:Organophosphonates