Convenient one pot synthesis and antimicrobial evaluation of some new Mannich bases carrying 4-methylthiobenzyl moiety.
Two new series of Mannich bases, namely, 1-(morpholino)methyl-3-(4-methylthiobenzyl)-4-(substituted arylidene)amino-1,2,4-triazol-5-thiones 3 and 1-(N-methylpiperazino)methyl-3-(4-methylthiobenzyl)-4-(substituted arylidene)amino-1,2,4-triazol-5-thiones 4 have been synthesized by a three-component Mannich reaction (MCR) involving 3-(4-methylthiobenzyl)-4-(substituted arylidene)amino-5-mercapto-1,2,4-triazoles 2, formaldehyde and morpholine/N-methylpiperazine. The newly synthesized compounds were well characterized by elemental analysis, IR, (1)H NMR and mass spectral studies. They were also screened for their antibacterial and antifungal activities against a variety of microorganisms and the results of such studies have been discussed in this article.
Ashok
Mithun
M
Department of Post-Graduate Studies and Research in Chemistry, Mangalore University, Mangalagangothri 574 199, Mangalore, Karnataka, India. mithun41@rediffmail.com
Holla
Bantwal Shivarama
BS
Poojary
Boja
B
D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D005658:Fungi / Q000187:drug effects; D006576:Heterocyclic Compounds, 4 or More Rings / Q000138:chemical synthesis* / Q000494:pharmacology; D013057:Spectrum Analysis; D013871:Thiones / Q000138:chemical synthesis* / Q000494:pharmacology
D000890:Anti-Infective Agents; D006576:Heterocyclic Compounds, 4 or More Rings; D013871:Thiones