title: Autonomic neuropathy in mixed cryoglobulinemia.
abstract: A retrospective, cross-sectional study was performed on a series of HCV-related mixed cryoglobulinemia (HCV-MC) patients to assess autonomic neuropathy (AN) and its relation to peripheral neuropathy (PN). Thirty consecutive patients affected by HCV-MC underwent clinical, neurological and electrodiagnostic examinations. Autonomic nervous system (ANS) involvement was assessed by functional cardiovascular tests and sympathetic skin response (SSR) evaluation. Sural nerve biopsy was performed in 10 patients with PN. All patients received steroids, 15 also received recombinant interferon-alpha2b (RIfn-alpha2b). PN occurred in 27 patients (90.0%) and AN in 4 (13.3 %) all with signs of PN. SSR was the autonomic test more frequently altered. Biopsy disclosed axonal degeneration more evident in the 4 patients with AN. Three out of 4 patients with AN received steroids and rIFN-alpha2b and 1 steroids alone. In our study on HCV-MC, it was concluded that AN can occur also without dysautonomic symptoms, SSR appears to be one of the optional tests to use together with dysautonomic tests to identify AN and finally PN and AN do not seem to be positively influenced by addition of rIFN-alpha2b to steroid treatment.
authors.affiliation: Department of Neurological Sciences, Second University of Naples, Piazza Miraglia 2, 80138 Naples, Italy. angelo.ammendola@unina2.it
authors.forename: A
authors.initials: A
authors.lastname: Ammendola
authors.forename: S
authors.initials: S
authors.lastname: Sampaolo
authors.forename: S
authors.initials: S
authors.lastname: Migliaresi
authors.forename: L
authors.initials: L
authors.lastname: Ambrosone
authors.forename: E
authors.initials: E
authors.lastname: Ammendola
authors.forename: G
authors.initials: G
authors.lastname: Ciccone
authors.forename: G
authors.initials: G
authors.lastname: Di Iorio
mesh_terms: D000200:Action Potentials / Q000502:physiology / Q000528:radiation effects; D000328:Adult; D000368:Aged; D001342:Autonomic Nervous System Diseases / Q000150:complications* / Q000188:drug therapy; D003430:Cross-Sectional Studies; D003449:Cryoglobulinemia / Q000150:complications* / Q000188:drug therapy / Q000209:etiology / Q000821:virology; D004576:Electromyography; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006526:Hepatitis C / Q000150:complications; D006801:Humans; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000503:physiopathology; D009431:Neural Conduction / Q000502:physiology; D011241:Prednisone / Q000627:therapeutic use; D012189:Retrospective Studies; D018709:Statistics, Nonparametric; D013497:Sural Nerve / Q000473:pathology / Q000503:physiopathology*
chemical_list: D005938:Glucocorticoids; D011241:Prednisone