title: Biological evaluation of fluorinated p-boronophenylalanine derivatives as a boron carrier.
abstract: Boron neutron capture therapy (BNCT) and magnetic resonance imaging (MRI) are quite attractive techniques for treatment and diagnosis of cancer, respectively. In order to develop practical materials utilizing both for BNCT and MRI, fluorinated p-boronophenylalanines and their alcohol derivatives had already been designed and synthesized. In the present paper the cytotoxicity, the incorporated amount into cancer cells, and the tumor cell killing effects of these compounds were elucidated to evaluate their usefulness as a boron carrier.
authors.affiliation: Faculty of Science and Technology, Kinki University, Higashi-osaka, Osaka 577-8502, Japan.
authors.forename: Yoshihide
authors.initials: Y
authors.lastname: Hattori
authors.forename: Kei
authors.initials: K
authors.lastname: Kurihara
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Kondoh
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Asano
authors.forename: Mitsunori
authors.initials: M
authors.lastname: Kirihata
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Yamaguchi
authors.forename: Tateaki
authors.initials: T
authors.lastname: Wakamiya
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D001895:Boron / Q000378:metabolism*; D001896:Boron Compounds / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D004354:Drug Screening Assays, Antitumor; D005910:Glioma / Q000473:pathology; D006845:Hydrocarbons, Fluorinated / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology*; D017136:Ion Transport; D008954:Models, Biological; D010649:Phenylalanine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D051381:Rats; D012995:Solubility; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D001896:Boron Compounds; D006845:Hydrocarbons, Fluorinated; D010649:Phenylalanine; D001895:Boron; C033685:4-boronophenylalanine