title: An effective management regimen for laryngeal granuloma caused by gastro-esophageal reflux: combination therapy with suggestions for lifestyle modifications.
abstract: According to our previous study, lifestyle modification in combination with drug therapy is much more effective than drug therapy alone in cases of laryngopharyngeal reflux (LPR). Most patients with LPR will have chronic gastro-esophageal reflux diseases (GERD) and require long-term medical therapy for control, resulting in high total expenditure on pharmacologic agents. We combined pharmacologic management with lifestyle modifications for the management of GERD with successful outcomes in patients with GERD-related laryngeal granulomas. Although further studies are needed, guidance concerning lifestyle modifications in combination with PPI therapy may be not only a clinically effective but also a cost-effective method for the management of laryngeal granulomas caused by gastro-esophageal reflux.
authors.affiliation: Department of Artificial Organs and Otolaryngology, National Institute of Sensory Organs, Tokyo, Japan. tsunodakoichi@kankakuki.go.jp
authors.forename: Koichi
authors.initials: K
authors.lastname: Tsunoda
authors.forename: Shin-Ichi
authors.initials: S
authors.lastname: Ishimoto
authors.forename: Mitsuya
authors.initials: M
authors.lastname: Suzuki
authors.forename: Makoto
authors.initials: M
authors.lastname: Hara
authors.forename: Hiroya
authors.initials: H
authors.lastname: Yamaguchi
authors.forename: Masahiro
authors.initials: M
authors.lastname: Sugimoto
authors.forename: Satoshi
authors.initials: S
authors.lastname: Takeuchi
authors.forename: Takaharu
authors.initials: T
authors.lastname: Nito
authors.forename: Ryuzaburo
authors.initials: R
authors.lastname: Higo
authors.forename: Hideto
authors.initials: H
authors.lastname: Saigusa
authors.forename: Atsunobu
authors.initials: A
authors.lastname: Tsunoda
authors.forename: Niro
authors.initials: N
authors.lastname: Tayama
mesh_terms: D000368:Aged; D000897:Anti-Ulcer Agents / Q000627:therapeutic use; D003131:Combined Modality Therapy; D005764:Gastroesophageal Reflux / Q000150:complications*; D006099:Granuloma / Q000209:etiology* / Q000378:metabolism / Q000628:therapy*; D006293:Health Promotion; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007818:Laryngeal Diseases / Q000209:etiology* / Q000378:metabolism / Q000628:therapy*; D007820:Laryngeal Mucosa / Q000378:metabolism; D008019:Life Style; D008297:Male; D008875:Middle Aged
chemical_list: D000897:Anti-Ulcer Agents