title: Significance of tissue anisotropy in optical tomography of the infant brain.
abstract: We study the effect of tissue anisotropy in optical tomography of neonates. A Monte Carlo method capable of modeling photon migration in an arbitrary 3D tissue model with spatially varying optical properties and tissue anisotropy is used for simulating measurements of neonates. Anatomical and diffusion tensor magnetic resonance imaging of neonates are used for creating the anatomical models. We find that tissue anisotropy affects the measured signal and the pattern of sensitivity in optical measurements.
authors.affiliation: BioMag Laboratory, Helsinki University Central Hospital, Helsinki, Finland. juha.heiskala@iki.fi
authors.forename: Juha
authors.initials: J
authors.lastname: Heiskala
authors.forename: Tuomas
authors.initials: T
authors.lastname: Neuvonen
authors.forename: P Ellen
authors.initials: PE
authors.lastname: Grant
authors.forename: Ilkka
authors.initials: I
authors.lastname: Nissilä
mesh_terms: D000465:Algorithms; D016880:Anisotropy; D016477:Artifacts; D001921:Brain / Q000033:anatomy & histology*; D003198:Computer Simulation; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D007223:Infant; D007231:Infant, Newborn; D008959:Models, Neurological; D015233:Models, Statistical; D009010:Monte Carlo Method; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D041622:Tomography, Optical / Q000379:methods*