title: Ether and crown ether-containing cationic 99mTc complexes useful as radiopharmaceuticals for heart imaging.
abstract: While radiopharmaceutical research has been focused on the development of target-specific radiotracers for early detection and radiotherapy of cancers in the last decade, there is a limited effort on new cationic 99mTc radiotracers for heart imaging. This review will summarize some of the most recent developments in ether- and crown ether-containing cationic 99mTc radiotracers that have a fast liver clearance with a heart/liver ratio substantially better than that of 99mTc-Sestamibi and 99mTc-Tetrofosmin, the two commercial 99mTc radiopharmaceuticals currently available for myocardial perfusion imaging. Fast liver clearance might shorten the duration of imaging protocols (<30 min post-injection), and allow for early acquisition of heart images of high quality. Improvement of heart/liver ratio may permit better detection of the presence and extent of coronary artery disease. Identification of such a new radiotracer that allows for the improved non-invasive delineation of myocardial perfusion would be of considerable benefit in treatment of patients with suspected coronary artery disease.
authors.affiliation: School of Health Sciences, Purdue University, 550 Stadium Mall Drive, West Lafayette, IN 47907, USA. lius@pharmacy.purdue.edu
authors.forename: Shuang
authors.initials: S
authors.lastname: Liu
mesh_terms: D000818:Animals; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003326:Coronary Circulation / Q000502:physiology; D043844:Crown Ethers / Q000737:chemistry* / Q000493:pharmacokinetics; D018360:Crystallography, X-Ray; D019450:Genes, MDR / Q000235:genetics; D006321:Heart / Q000000981:diagnostic imaging*; D006801:Humans; D008099:Liver / Q000378:metabolism; D019275:Radiopharmaceuticals / Q000138:chemical synthesis / Q000737:chemistry* / Q000493:pharmacokinetics; D013667:Technetium / Q000737:chemistry* / Q000493:pharmacokinetics; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D043844:Crown Ethers; D019275:Radiopharmaceuticals; D013667:Technetium