Integrating transcriptome, proteome and glycome analyses of Schistosoma biology.
Publication of the transcriptomes of Schistosoma mansoni and Schistosoma japonicum, in conjunction with the sequencing and assembly of their genomes, has generated a comprehensive picture of Schistosoma transcriptional and genomic diversity. Subsequently, researchers who study conjugal and developmental biology, tegumental composition and larval or egg, secretory and excretory products have used these data, in combination with the latest '-omics' technologies, to extend large-scale screens of the schistosome transcriptome, proteome and glycome. In this article, we review these postgenomic investigations and contend that the generated datasets provide a plethora of novel drug, vaccine and immunomodulatory targets that might be useful for developing new antischistosome agents.
Hokke
Cornelis H
CH
Department of Parasitology, Center of Infectious Diseases, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands.
Fitzpatrick
Jennifer M
JM
Hoffmann
Karl F
KF
D000818:Animals; D005260:Female; D020869:Gene Expression Profiling; D049751:Genome, Helminth; D015801:Helminth Proteins / Q000235:genetics / Q000378:metabolism*; D008297:Male; D009017:Morbidity; D020411:Oligonucleotide Array Sequence Analysis; D011134:Polysaccharides / Q000378:metabolism*; D020543:Proteome; D040901:Proteomics; D012549:Schistosoma japonicum / Q000235:genetics / Q000378:metabolism* / Q000502:physiology; D012550:Schistosoma mansoni / Q000235:genetics / Q000378:metabolism* / Q000502:physiology; D012552:Schistosomiasis / Q000453:epidemiology
D015801:Helminth Proteins; D011134:Polysaccharides; D020543:Proteome