[Experimental cirrhosis of the liver obtained with simultaneous carbon tetrachloride and phenobarbital sodium].
Phenobarbital sodium considerably increases the liver toxicity of CCl4. The onset and course of cirrhosis induced by simultaneous oral phenobarbital sodium and inhaled CCl4 were studied in a large number of rats. The apparatus and method used are described. The results observed are expressed in terms of survival, variations in liver and spleen weight, and the gross and microscopic liver picture. The method is considered for optimal for the rapid induction of marked and typical cirrhosis in the rat.
Colombo
P
P
Laboratorio di Chirurgia Sperimentale e di Fisiopatologia Chirurgica, Istituto di Clinica Chirurgica Generale e Terapia Chirurgica dell'Università di Pavia.
Savio
S
S
Cavallero
M
M
Fiaccadori
C
C
D000284:Administration, Oral; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002251:Carbon Tetrachloride / Q000008:administration & dosage / Q000633:toxicity*; D003128:Coma / Q000139:chemically induced; D004357:Drug Synergism; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced; D008099:Liver / Q000473:pathology; D008106:Liver Cirrhosis, Experimental / Q000139:chemically induced* / Q000473:pathology; D017093:Liver Failure / Q000139:chemically induced; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010634:Phenobarbital / Q000008:administration & dosage / Q000633:toxicity*; D051381:Rats; D011917:Rats, Inbred Lew; D012131:Respiratory Insufficiency / Q000139:chemically induced; D013154:Spleen / Q000473:pathology
D002251:Carbon Tetrachloride; D010634:Phenobarbital