title: Engineering approaches to biomanipulation.
abstract: This article presents a review on the existing techniques for manipulating biological cells. Because biomanipulation involves a wide range of disciplines, from biology to engineering, we concentrate on some of the key methodologies that would result in an efficient biomanipulation system. Some of the key methodologies discussed in this article for cell manipulation relate to the use of magnetics, microelectromechanical systems (MEMS)-based approaches, optics, electric field, and mechanical techniques. Recent advances in engineering have allowed researchers worldwide to address the problems arising from conventional manipulation techniques. This paper assimilates significance and limitations of biomanipulation techniques described in the literature.
authors.affiliation: Department of Mechanical Engineering, University of Maryland, College Park, Maryland 20740, USA. jaydev@umd.edu
authors.forename: Jaydev P
authors.initials: JP
authors.lastname: Desai
authors.forename: Anand
authors.initials: A
authors.lastname: Pillarisetti
authors.forename: Ari D
authors.initials: AD
authors.lastname: Brooks
mesh_terms: D001698:Biomedical Engineering / Q000295:instrumentation / Q000379:methods*; D018929:Cell Culture Techniques / Q000295:instrumentation / Q000379:methods*; D002468:Cell Physiological Phenomena; D002469:Cell Separation / Q000295:instrumentation / Q000379:methods*; D005434:Flow Cytometry / Q000295:instrumentation / Q000379:methods*; D008280:Magnetics; D008846:Micromanipulation / Q000295:instrumentation / Q000379:methods*