title: Neutrophil VCS parameters are superior indicators for acute infection.
abstract: A reliable and cost-effective laboratory method for diagnosing early bacterial infection is needed. The purpose of this study is to compare the sensitivity and specificity of the mean neutrophil volume (MNV) and neutrophil volume distribution width (NDW) parameters with manual band counts, as well as absolute neutrophil count (ANC) and Creactive protein (CRP). We analyzed the clinical history and laboratory data from 242 adult patients with subsequent randomization into 3 groups: patients with no apparent clinical evidence of infection (group 1), localized infection (group 2), and severe infection (group 3). Total white blood cell counts, percentage of neutrophils, ANC, band counts, MNV, and NDW were progressively elevated from group 1 to group 3. There were good correlations between MNV and ANC (P < .05) or band counts (P < .001). Similarly, the NDW correlated well with ANC (P < .001) and band counts (P < .05). Statistical analyses further confirmed that the MNV and NDW were better parameters, with larger areas under the curve than those of CRP, band count, and ANC. The neutrophil VCS parameters, MNV and NDW, have superior sensitivity and specificity compared to manual band count, ANC, and CRP. MNV and NDW are useful indicators in diagnosing acute infectious processes.
authors.affiliation: Department of Pathology and Laboratory Medicine, Boston Medical Center, Boston, Massachusetts, USA.
authors.forename: Robert
authors.initials: R
authors.lastname: Bagdasaryan
authors.forename: Zhongren
authors.initials: Z
authors.lastname: Zhou
authors.forename: Bethany
authors.initials: B
authors.lastname: Tierno
authors.forename: Dara
authors.initials: D
authors.lastname: Rosenman
authors.forename: Dongsheng
authors.initials: D
authors.lastname: Xu
mesh_terms: D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D005260:Female; D006801:Humans; D007239:Infections / Q000175:diagnosis*; D007958:Leukocyte Count / Q000295:instrumentation / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000166:cytology*; D012189:Retrospective Studies; D012680:Sensitivity and Specificity
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein