[Lysophosphatidic acid promotes transplanted tumor growth of human epithelium ovarian cancer in nude mice].
OBJECTIVE
To investigate effect of lysophosphatidic acid (LPA) on growth and metastasis of intraperitonally transplanted tumor in nude mice.


METHODS
Sixteen nude mice randomly divided into control group and LPA treatment group, in which 6x10(6) untreated and LPA-treated human ovarian cancer cells skov3 were respectively transplanted intraperitoneally. After death of the nude mice without interventions, the weight of the transplanted tumors and number of metastatic tumors were recorded.


RESULTS
The rate of tumor formation was 100%in both groups, but the treatment group showed more rapid tumor growth, greater tumor weight and more numerous metastatic tumors than the control group (P<0.01).


CONCLUSIONS
LPA simulates the growth and promotes invasiveness of transplanted ovarian cancer cells in the peritoneal cavity of nude mie.
Wang
Hui
H
Department of Gynecology, Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China. weihui1973@163.com
Wu
Xiao-Hua
XH
Shi
Li
L
D000818:Animals; D005260:Female; D008246:Lysophospholipids / Q000633:toxicity*; D051379:Mice; D008819:Mice, Nude; D009361:Neoplasm Invasiveness; D009368:Neoplasm Transplantation; D010051:Ovarian Neoplasms / Q000473:pathology*; D010534:Peritoneal Neoplasms / Q000139:chemically induced / Q000556:secondary*; D011897:Random Allocation; D014183:Transplantation, Heterologous; D047368:Tumor Burden / Q000187:drug effects
D008246:Lysophospholipids; C032881:lysophosphatidic acid