title: Association of matrix metalloproteinase-1 (-1607 1G/2G) polymorphism with increased risk for oral squamous cell carcinoma.
abstract: BACKGROUND
  The purpose of this study was to investigate the possible relation of matrix metalloproteinase-1 (MMP-1) to increased risk for oral cancer, in light of recently found contribution of angiogenesis and thrombosis-related factors to the development of malignancies.
  
  
  METHODS
  The 1G/2G polymorphism in the MMP-1 gene, which influences its expression, was examined in 156 patients with oral squamous cell carcinoma and 141 healthy controls of comparable ethnicity (Greeks and Germans), gender and age.
  
  
  RESULTS
  In comparison to controls, the detected 2G allele frequency was significantly lower in the patient group and in subgroups with early cancer stages, with positive family history of thrombophilia, with tobacco abuse and without alcohol abuse (p < 0.05). These findings were mainly due to a significant decrease in 2G/2G homozygotes despite a small increase in 1G/2G heterozygotes in the above groups.
  
  
  CONCLUSIONS
  These findings suggest a significant involvement of the MMP-1 -1607 1G/2G polymorphism in the increasing risk for oral cancer in the 1G allele European carriers.
authors.affiliation: Department of Oral and Maxillofacial Surgery, University of Athens Medical School, Vas. Sofias 93 and Dim. Soutsou 1, Athens 11521, Greece. lvairakt@med.uoa.gr
authors.forename: Eleftherios
authors.initials: E
authors.lastname: Vairaktaris
authors.forename: Christos
authors.initials: C
authors.lastname: Yapijakis
authors.forename: Spyridoula
authors.initials: S
authors.lastname: Derka
authors.forename: Zoe
authors.initials: Z
authors.lastname: Serefoglou
authors.forename: Stavros
authors.initials: S
authors.lastname: Vassiliou
authors.forename: Emeka
authors.initials: E
authors.lastname: Nkenke
authors.forename: Vassilis
authors.initials: V
authors.lastname: Ragos
authors.forename: Antonis
authors.initials: A
authors.lastname: Vylliotis
authors.forename: Sofia
authors.initials: S
authors.lastname: Spyridonidou
authors.forename: Christos
authors.initials: C
authors.lastname: Tsigris
authors.forename: Athanasios
authors.initials: A
authors.lastname: Yannopoulos
authors.forename: Christina
authors.initials: C
authors.lastname: Tesseromatis
authors.forename: Friedrich W
authors.initials: FW
authors.lastname: Neukam
authors.forename: Efstratios
authors.initials: E
authors.lastname: Patsouris
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D002294:Carcinoma, Squamous Cell / Q000201:enzymology* / Q000235:genetics; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D020781:Matrix Metalloproteinase 1 / Q000235:genetics*; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000201:enzymology* / Q000235:genetics; D011110:Polymorphism, Genetic
chemical_list: D020781:Matrix Metalloproteinase 1