title: Recurrent prostatic stromal sarcoma with massive high-grade prostatic intraepithelial neoplasia.
abstract: A unique case of prostatic stromal sarcoma (PSS) that recurred in the pelvic cavity with massive high-grade prostatic intraepithelial neoplasia is described. A 52-year-old man who presented with urinary retention underwent a radical cystoprostatectomy. Tumour tissues of the prostate showed an admixture of hyperplastic glands and markedly cellular stroma of spindle cells arranged in a fascicular pattern, and the tumour was diagnosed as PSS. 66 months after the operation, CT scans revealed three recurrent tumours around the bilateral obturator and left fore iliopsoas. The recurrent tumours were biphasic neoplasms, as before, but the epithelial component had grown prominent and manifested overt atypia in a manner resembling high-grade prostatic intraepithelial neoplasia. Our findings suggest that not only the stromal component but also and the epithelial components of PSS may have malignant potential.
authors.affiliation: Department of Human Pathology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan. tmorikawa-tky@umin.ac.jp
authors.forename: Teppei
authors.initials: T
authors.lastname: Morikawa
authors.forename: Akiteru
authors.initials: A
authors.lastname: Goto
authors.forename: Kyoichi
authors.initials: K
authors.lastname: Tomita
authors.forename: Yuzuri
authors.initials: Y
authors.lastname: Tsurumaki
authors.forename: Satoshi
authors.initials: S
authors.lastname: Ota
authors.forename: Tadaichi
authors.initials: T
authors.lastname: Kitamura
authors.forename: Masashi
authors.initials: M
authors.lastname: Fukayama
mesh_terms: D006801:Humans; D008297:Male; D008875:Middle Aged; D018198:Mixed Tumor, Malignant / Q000473:pathology* / Q000556:secondary; D011468:Prostatectomy; D019048:Prostatic Intraepithelial Neoplasia / Q000473:pathology* / Q000556:secondary; D011471:Prostatic Neoplasms / Q000473:pathology*; D012509:Sarcoma / Q000473:pathology* / Q000556:secondary