Network formation of tissue cells via preferential attraction to elongated structures.
Vascular and nonvascular cells often form an interconnected network in vitro, similar to the early vascular bed of warm-blooded embryos. Our time-lapse recordings show that the network forms by extending sprouts, i.e., multicellular linear segments. To explain the emergence of such structures, we propose a simple model of preferential attraction to stretched cells. Numerical simulations reveal that the model evolves into a quasistationary pattern containing linear segments, which interconnect above the critical volume fraction of 0.2. In the quasistationary state, the generation of new branches offset the coarsening driven by surface tension. In agreement with empirical data, the characteristic size of the resulting polygonal pattern is density-independent within a wide range of volume fractions.
Szabo
Andras
A
Department of Biological Physics, Eotvos University, Budapest, Hungary.
Perryn
Erica D
ED
Czirok
Andras
A
D000818:Animals; D001253:Astrocytes / Q000166:cytology; D001808:Blood Vessels / Q000196:embryology; D004622:Embryo, Mammalian / Q000166:cytology*; D047108:Embryonic Development / Q000502:physiology*; D042783:Endothelial Cells / Q000166:cytology; D051379:Mice; D008954:Models, Biological; D009132:Muscles / Q000166:cytology / Q000196:embryology; D009420:Nervous System / Q000196:embryology