title: Endocervical component in conventional cervical smears: influence on detection of squamous cytologic abnormalities.
abstract: The objective of this study was to correlate the number of endocervical cells and the number of atypical cells in cervical smears with cytological abnormalities to verify if a higher number of endocervical cells would implicate in a higher number of squamous atypical cells. In this cross sectional study, it was made a blinded review of 294 conventional cervical smears. The consensus diagnoses reached by the blinded review by three observers included 213 low-grade squamous intraepithelial lesions (LSILs) and 81 high-grade squamous intraepithelial lesions (HSILs). In each cervical smear were computed the number of endocervical cells and the number of squamous atypical cells, and it was established the following score: one (0-5 cells); two (6-10 cells); three (11-25 cells); four (26-50 cells); and five (more than 50 cells). Compared to the smears with an account of endocervical cells classified in score 1 (0-5 cells), an account of more than 50 endocervical cells was significantly associated to the presence of at least 10 squamous atypical cells in the cervical smears (OR 2.87 95% CI 1.54-5.35). Data from this study suggest that there is a positive association between the number of endocervical cells and the number of squamous atypical cells suggestive of SIL.
authors.affiliation: Cytology Division, School of Pharmacy, Universidade Federal de Goiás (UFG), CEP 74110-100 Goiânia, GO, Brazil.
authors.forename: Andrea Alves
authors.initials: AA
authors.lastname: Ribeiro
authors.forename: Sonia do Carmo Diniz dos
authors.initials: Sdo C
authors.lastname: Santos
authors.forename: Sonia Regina Rosa
authors.initials: SR
authors.lastname: de Souza e Silva
authors.forename: Marcilene Aparecida do
authors.initials: MA
authors.lastname: Nascimento
authors.forename: Gislaine Aparecida
authors.initials: GA
authors.lastname: Fonsechi-Carvasan
authors.forename: Megmar Aparecida Santos
authors.initials: MA
authors.lastname: Carneiro
authors.forename: Mayra
authors.initials: M
authors.lastname: Rabelo-Santos
authors.forename: Silvia Helena
authors.initials: SH
authors.lastname: Rabelo-Santos
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000175:diagnosis*; D003430:Cross-Sectional Studies; D004847:Epithelial Cells / Q000473:pathology*; D005260:Female; D006801:Humans; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis*; D014626:Vaginal Smears / Q000379:methods*; D002578:Uterine Cervical Dysplasia / Q000175:diagnosis*