Influence of dietary fiber on inflammatory bowel disease and colon cancer: importance of fermentation pattern.
The benefits of dietary fiber on inflammatory bowel disease may be related to the fermentative production of butyrate in the colon, which appears to decrease the inflammatory response. The benefits of dietary fiber against colon cancer may be related to both fermentative and non-fermentative processes, although poorly fermentable fibers appear more influential. Dietary fiber fermentation profiles are important in determining optimal fibers for colonic health, and may be a function of structure, processing conditions, and other food components. A greater understanding of the relationships between fermentation rate and dietary fiber structure would allow for development of dietary fibers for optimum colonic health.
Rose
Devin J
DJ
Whistler Center for Carbohydrate Research and Department of Food Science, Purdue University, 760 Agriculture Mall, West Lafayette, IN 47907, USA.
DeMeo
Mark T
MT
Keshavarzian
Ali
A
Hamaker
Bruce R
BR
D000818:Animals; D003110:Colonic Neoplasms / Q000453:epidemiology*; D004043:Dietary Fiber / Q000008:administration & dosage*; D005232:Fatty Acids, Volatile / Q000096:biosynthesis; D005285:Fermentation; D005769:Gastrointestinal Motility; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000453:epidemiology*
D004043:Dietary Fiber; D005232:Fatty Acids, Volatile