title: Time-of-flight flow imaging of two-component flow inside a microfluidic chip.
abstract: Here we report on using NMR imaging and spectroscopy in conjunction with time-of-flight tracking to noninvasively tag and monitor nuclear spins as they flow through the channels of a microfluidic chip. Any species with resolvable chemical-shift signatures can be separately monitored in a single experiment, irrespective of the optical properties of the fluids, thereby eliminating the need for foreign tracers. This is demonstrated on a chip with a mixing geometry in which two fluids converge from separate channels, and is generally applicable to any microfluidic device through which fluid flows within the nuclear spin-lattice relaxation time.
authors.affiliation: Materials Sciences Division, Lawrence Berkeley National Laboratory, and Department of Chemistry, University of California, Berkeley, CA 94720, USA.
authors.forename: Elad
authors.initials: E
authors.lastname: Harel
authors.forename: Christian
authors.initials: C
authors.lastname: Hilty
authors.forename: Katherine
authors.initials: K
authors.lastname: Koen
authors.forename: Erin E
authors.initials: EE
authors.lastname: McDonnell
authors.forename: Alex
authors.initials: A
authors.lastname: Pines