Ligands for programmed cell death 1 gene in patients with systemic lupus erythematosus.
OBJECTIVE
To investigate the role of ligands for programmed cell death 1 (PD-L) in the pathogenesis of systemic lupus erythematosus (SLE).


METHODS
One hundred sixty-four patients with SLE and 160 healthy controls were enrolled in our study. The PD-L1 and PD-L2 polymorphisms were determined by polymerase chain reaction (PCR)/direct sequencing or restriction fragment length polymorphism (RFLP)-PCR.


RESULTS
The genotype distributions of PD-L2 47103 C/T polymorphisms in patients with SLE were significantly different from those of the controls (p = 0.003). The genotype frequency of PD-L2 47103 T/T, in comparison with 47103 C/C, was significantly increased in patients with SLE when compared with that of the controls (odds ratio 2.5, 95% confidence interval 1.4-4.4, p = 0.001). A similar finding could also be found in the allele frequency of PD-L2 47103 T (SLE vs control, OR 1.7, 95% CI 1.3-2.4, p = 0.001). There were no significant differences in the genotype and allele frequencies of PD-L1 polymorphisms between the patients and controls.


CONCLUSIONS
PD-L2 47103 T may be associated with susceptibility to SLE in Taiwan.
Wang
Shu-Chen
SC
Department of Laboratory Medicine and Division of Rheumatology, Kaohsiung Medical University Hospital, Taiwan.
Lin
Chia-Hui
CH
Ou
Tsan-Teng
TT
Wu
Cheng-Chin
CC
Tsai
Wen-Chan
WC
Hu
Chaur-Jong
CJ
Liu
Hong-Wen
HW
Yen
Jeng-Hsien
JH
D015703:Antigens, CD / Q000235:genetics* / Q000276:immunology; D060890:B7-H1 Antigen; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000235:genetics* / Q000276:immunology; D008180:Lupus Erythematosus, Systemic / Q000235:genetics*; D008297:Male; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D061027:Programmed Cell Death 1 Ligand 2 Protein; D013624:Taiwan
D015703:Antigens, CD; D060890:B7-H1 Antigen; C423236:CD274 protein, human; D036341:Intercellular Signaling Peptides and Proteins; C556977:PDCD1LG2 protein, human; D061027:Programmed Cell Death 1 Ligand 2 Protein