title: A novel MRI texture analysis of demyelination and inflammation in relapsing-remitting experimental allergic encephalomyelitis.
abstract: We have developed a novel multiscale localized image texture analysis technique, based upon the polar Stockwell Transform (PST). In this paper we characterized image texture in vivo using the PST in histologically verified lesion areas in T2-weighted MRI of an animal model of multiple sclerosis. Both high and low frequency signals, representing inflammation and demyelination, were significantly increased in pathological regions compared to normal control tissue. This suggests that this new local spatial-frequency measure of image texture may provide a sensitive and precise indication of disease activity.
authors.affiliation: Department of Radiology, University of Calgary, Calgary, Alberta, Canada. yunyzhan@ucalgary.ca
authors.forename: Yunyan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Jennifer
authors.initials: J
authors.lastname: Wells
authors.forename: Richard
authors.initials: R
authors.lastname: Buist
authors.forename: James
authors.initials: J
authors.lastname: Peeling
authors.forename: V Wee
authors.initials: VW
authors.lastname: Yong
authors.forename: J Ross
authors.initials: JR
authors.lastname: Mitchell
mesh_terms: D000465:Algorithms; D000818:Animals; D001921:Brain / Q000473:pathology*; D002908:Chronic Disease; D004195:Disease Models, Animal; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000175:diagnosis*; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D051379:Mice; D009103:Multiple Sclerosis / Q000175:diagnosis*; D012008:Recurrence; D012075:Remission, Spontaneous; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity