Neurological and functional recovery in human stroke are associated with peripheral blood CD34+ cell mobilization.
BACKGROUND
A spontaneous mobilization of Peripheral Blood-Mononuclear CD34+ Cells (PB-MNC-CD34+) has recently been reported in human myocardial infarction and found to be related to improved heart function and survival. However, nothing is known regarding a possible relation between PB-MNC-CD34+ mobilization and neurological recovery in human acute cerebral ischemia.


RESULTS
PB-MNC-CD34+ were determined daily after an acute cerebral ischemic attack for 14 days in 25 patients with acute ischemic stroke and compared with controls. Results indicated that stroke was followed by large and bursting mobilizations of PB-MNC-CD34+. The amplitude of the mobilizations was similar to those observed in Granulocyte Colony Stimulating Factor (G-CSF) conditioned aplastic patients following myeloablative therapy before leukapheresis and autologous bone graft. The extent of PB-MNC-CD34+ mobilization in each patient was directly related to neurological and functional recoveries as assessed by NIH Stroke Scale, and modified Rankin Scale respectively.


CONCLUSIONS
The mobilization of PB-MNC-CD34+ cells might be predictive of neurological and functional recovery.
Dunac
Antoine
A
Department of Neurology (Stroke Unit), University Hospital Pasteur, 30 avenue de la voie Romaine, Nice Cedex, BP69, 06002, France. dunac.a@chu-nice.fr
Frelin
Christian
C
Popolo-Blondeau
Margherita
M
Chatel
Marcel
M
Mahagne
Marie H
MH
Philip
Patrick J-M
PJ
D000328:Adult; D000368:Aged; D018952:Antigens, CD34 / Q000097:blood*; D001800:Blood Specimen Collection / Q000379:methods; D005260:Female; D005434:Flow Cytometry / Q000379:methods; D016179:Granulocyte Colony-Stimulating Factor / Q000494:pharmacology / Q000627:therapeutic use; D019650:Hematopoietic Stem Cell Mobilization; D006801:Humans; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination; D020127:Recovery of Function / Q000502:physiology*; D018709:Statistics, Nonparametric; D020521:Stroke / Q000097:blood* / Q000188:drug therapy / Q000473:pathology* / Q000503:physiopathology*; D013997:Time Factors
D018952:Antigens, CD34; D016179:Granulocyte Colony-Stimulating Factor