title: Placental site trophoblastic tumor with an ovarian metastasis.
abstract: Placental site trophoblastic tumors (PSTT) are the rarest form of gestational trophoblastic disease (GTD). The clinical management of PSTT differs from the other forms of GTD as surgery plays a more important role. The most common metastatic sites are the lung, liver, and vagina while spread to the adnexa is relatively unusual. We describe a case of a 35-year-old woman presenting with PSTT and ovarian metastasis who was successfully treated with radical hysterectomy, bilateral oophorectomy, pelvic lymph node dissection, and postoperative chemotherapy. The case highlights the possibility of ovarian metastases despite normal preoperative imaging and confirms the value of multidisciplinary management of this rare illness.
authors.affiliation: West London Cancer Centre, Hammersmith Hospitals NHS Trust, London, United Kingdom.
authors.forename: D
authors.initials: D
authors.lastname: Milingos
authors.forename: D
authors.initials: D
authors.lastname: Doumplis
authors.forename: P
authors.initials: P
authors.lastname: Savage
authors.forename: M
authors.initials: M
authors.lastname: Seckl
authors.forename: I
authors.initials: I
authors.lastname: Lindsay
authors.forename: J R
authors.initials: JR
authors.lastname: Smith
mesh_terms: D000328:Adult; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D009362:Neoplasm Metastasis; D010051:Ovarian Neoplasms / Q000188:drug therapy / Q000556:secondary* / Q000601:surgery; D011247:Pregnancy; D018245:Trophoblastic Tumor, Placental Site / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D014594:Uterine Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery