Myocardial infarction and venous thrombosis in a 42-year old woman with heterozygous methylenetetrahydrofolate reductase (MTHRF) gene mutation, hyperhomocysteinemia, and protein C deficiency.
OBJECTIVE
Hyperhomocysteinemia and protein C deficiency have synergistic effect on the onset of thrombotic disease.


METHODS
We report a 42-year old woman with myocardial infarction and venous thrombosis in whom recognition of heterozygous MTHRF gene mutation, hyperhomocysteinemia, and protein C deficiency.


RESULTS
The patient was treated successfully with coronary artery bypass graft surgery and systemic anticoagulation.


CONCLUSIONS
Our report emphasize that a combined hyperhomocysteinemia, and protein C deficiency may be a high risk factor for arterial and venous thromboembolic events in young adults. These patients might be candidates for indefinite anticoagulation.
Cakir
Omer
O
Ayyildiz
Orhan
O
Goz
Mustafa
M
Sit
Dede
D
Eren
Nesimi
N
D000328:Adult; D005260:Female; D006579:Heterozygote; D006801:Humans; D020138:Hyperhomocysteinemia / Q000150:complications*; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D009154:Mutation; D009203:Myocardial Infarction / Q000209:etiology*; D020151:Protein C Deficiency / Q000150:complications*; D020246:Venous Thrombosis / Q000209:etiology*
D042965:Methylenetetrahydrofolate Reductase (NADPH2)