title: Asymmetric catalysis for the construction of quaternary carbon centres: nucleophilic addition on ketones and ketimines.
abstract: There is a growing need in organic synthesis for efficient methodologies for the asymmetric synthesis of quaternary carbon centres. One of the most attractive and straightforward methods focuses on the use of asymmetric catalysis for the addition of various types of nucleophiles on prochiral ketones and ketimines. A view of the literature from this growing area of research will be presented in this review, with an emphasis on the pioneer works and milestones brought by the main players in this field.
authors.affiliation: Unité de chimie organique et médicinale, département de chimie, place Louis Pasteur 1, Université catholique de Louvain, 1348, Louvain la Neuve, Belgium. riant@chim.ucl.ac.be
authors.forename: Olivier
authors.initials: O
authors.lastname: Riant
authors.forename: Jérôme
authors.initials: J
authors.lastname: Hannedouche
mesh_terms: D002244:Carbon / Q000737:chemistry*; D002384:Catalysis; D003486:Cyanides / Q000737:chemistry; D007097:Imines / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry
chemical_list: D003486:Cyanides; D007097:Imines; D007659:Ketones; D009942:Organometallic Compounds; D002244:Carbon