title: [Gas chromatography with mass-selective detector in testing blood for amitriptyline and nortriptyline].
abstract: The article describes the method of simultaneous detection of amitriptiline and nortriptilin in cadaveric blood using gas chromatography with mass-selective detection. Preparation includes liquid-liquid extraction and derivation with trifluoroacetic anhydride. Nortriptilin threshold of detectability in the blood is 0.02 mcg/ml, amitriptilin one--0.05 mcg/ml. The range of detectability--0.05-3.0 mcg/ml for both compounds. Maximal error of the compounds detectability was under 12.9% for concentrations 0.10 mcg/ml and 10.6% for concentrations 2.0 mcg/ml. The method was tested on expert material in forensic chemical examinations.
authors.forename: A B
authors.initials: AB
authors.lastname: Melent'ev
authors.forename: S S
authors.initials: SS
authors.lastname: Kataev
authors.forename: E P
authors.initials: EP
authors.lastname: Ivanova
mesh_terms: D000639:Amitriptyline / Q000097:blood*; D000929:Antidepressive Agents, Tricyclic / Q000097:blood*; D002102:Cadaver; D053593:Forensic Toxicology / Q000295:instrumentation / Q000379:methods*; D008401:Gas Chromatography-Mass Spectrometry / Q000295:instrumentation / Q000379:methods*; D006801:Humans; D009661:Nortriptyline / Q000097:blood*; D012680:Sensitivity and Specificity
chemical_list: D000929:Antidepressive Agents, Tricyclic; D000639:Amitriptyline; D009661:Nortriptyline