title: Prolonged retrograde amnesia following sedation with propofol in a 12-year-old boy.
abstract: Propofol is commonly used for sedation in a variety of clinical settings, as well as for induction and maintenance of anesthesia. The ease with which propofol can be administered and titrated to clinical effect, in addition to its accepted safety profile, has made it the drug of choice for sedation in outpatient procedures, such as gastrointestinal endoscopy. While short-term amnesia is a well-known side-effect of propofol, we present the first documented case of prolonged retrograde amnesia following propofol administration in a pediatric patient. Possible mechanisms and clinical management strategies related to this unique event are discussed.
authors.affiliation: Division of Pediatric Neurology, Department of Anesthesiology, Pennsylvania State University College of Medicine, Hershey, PA, USA. squraishi@psu.edu
authors.forename: Sadeq A
authors.initials: SA
authors.lastname: Quraishi
authors.forename: Tyrone D
authors.initials: TD
authors.lastname: Girdharry
authors.forename: Shu-Guang
authors.initials: SG
authors.lastname: Xu
authors.forename: Fredrick K
authors.initials: FK
authors.lastname: Orkin
mesh_terms: D000648:Amnesia, Retrograde / Q000139:chemically induced* / Q000628:therapy; D018686:Anesthetics, Intravenous / Q000008:administration & dosage / Q000009:adverse effects*; D000779:Anesthetics, Local / Q000008:administration & dosage; D002648:Child; D016099:Endoscopy, Gastrointestinal / Q000379:methods; D005283:Fentanyl / Q000008:administration & dosage; D005764:Gastroesophageal Reflux / Q000601:surgery; D006801:Humans; D008012:Lidocaine / Q000008:administration & dosage; D008297:Male; D011939:Mental Recall / Q000187:drug effects; D011183:Postoperative Complications / Q000139:chemically induced* / Q000628:therapy; D015742:Propofol / Q000009:adverse effects*; D013995:Time
chemical_list: D018686:Anesthetics, Intravenous; D000779:Anesthetics, Local; D008012:Lidocaine; D005283:Fentanyl; D015742:Propofol