Effect of glycine on the immune response of the experimentally diabetic rats.
BACKGROUND
Hyperglycemia induces protein glycation, disturbing its function, additionally, the glycated products (AGEs) induce by themselves proinflammatory cytokine release that are responsible for insulin resistance. Glycine has been successfully used in diabetic patients to competitively reduce hemoglobin glycation.


OBJECTIVE
To assess hyperglycemia impact on the immune response and to evaluate if it is possible to reverse it by means of glycine administration.


METHODS
Streptozotocin-induced diabetic rats, with and without glycine administration were challenged with sheep red blood cells, and specific antibody producing cells were accounted. Normal rats were challenged as controls.


RESULTS
Induced diabetes modifies significantly the humoral immune response capacity versus sheep red blood cells. Also, glycine administration prevents against this deleterious effect.


CONCLUSIONS
Glycine could be an important therapeutic resource among diabetics to avoid the characteristic immunodeficiencies of this disease.
Lezcano Meza
Diana
D
Respiratory Diseases National Institute of Mexico, Xenotransplantation Laboratory, Infantile Hospital of Mexico Federico Gomez, Mexico. dianalm@iner.gob.mx
Terán Ortiz
Luis
L
Carvajal Sandoval
Guillermo
G
Gutiérrez de la Cadena
Mónica
M
Terán Escandón
David
D
Estrada Parra
Sergio
S
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D000921:Antibody-Producing Cells / Q000187:drug effects / Q000276:immunology; D001786:Blood Glucose / Q000032:analysis; D003921:Diabetes Mellitus, Experimental / Q000150:complications / Q000276:immunology*; D004353:Drug Evaluation, Preclinical; D004912:Erythrocytes / Q000276:immunology; D006442:Glycated Hemoglobin / Q000032:analysis; D017127:Glycation End Products, Advanced / Q000032:analysis; D005998:Glycine / Q000494:pharmacology / Q000627:therapeutic use*; D007153:Immunologic Deficiency Syndromes / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012756:Sheep; D013311:Streptozocin
D001786:Blood Glucose; D006442:Glycated Hemoglobin; D017127:Glycation End Products, Advanced; D005998:Glycine; D013311:Streptozocin