title: Alternate approach to understanding the molecular mechanisms of stroke-induced injury.
abstract: Research in the area of stroke has not yielded any new treatments, besides tissue plasminogen activator. New findings are suggesting that the therapeutic window of providing neuroprotection is wider than once thought. Moreover, the role of the peripheral immune system in abetting neurodegeneration is being elucidated, but it appears this reaction occurs 2-3 days after the stroke. This mini-review examines this new evidence about the molecular mechanisms leading to stroke-induced neuronal death, which suggests new therapeutic approaches to its treatment.
authors.affiliation: Department of Neurosurgery, Center of Excellence for Aging and Brain Repair, University of South Florida, Florida, USA.
authors.forename: A E
authors.initials: AE
authors.lastname: Willing
authors.forename: K R
authors.initials: KR
authors.lastname: Pennypacker
mesh_terms: D000818:Animals; D001921:Brain / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D020925:Hypoxia-Ischemia, Brain / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D009410:Nerve Degeneration / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D013154:Spleen / Q000502:physiology; D020521:Stroke / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D013997:Time Factors