title: Paraneoplastic myopathy: response to intravenous immunoglobulin.
abstract: Necrotizing myopathy is an unusual and severe form of paraneoplastic myopathy in which inflammation is minimal or absent. We report two cases of necrotizing myopathy which demonstrated significant response to intravenous immunoglobulin (IVIG) (one in spite of tumor progression). A third case represents the first association of anti-signal recognition particle (anti-SRP) syndrome with large-cell lung cancer. These cases highlight the role of histopathologic diagnosis in directing the treatment of paraneoplastic myopathy, and the role for IVIG in treatment of the syndrome.
authors.affiliation: Department of Neurology, University of Utah, Salt Lake City, UT, USA.
authors.forename: J B
authors.initials: JB
authors.lastname: Sampson
authors.forename: S M
authors.initials: SM
authors.lastname: Smith
authors.forename: A G
authors.initials: AG
authors.lastname: Smith
authors.forename: J R
authors.initials: JR
authors.lastname: Singleton
authors.forename: S
authors.initials: S
authors.lastname: Chin
authors.forename: A
authors.initials: A
authors.lastname: Pestronk
authors.forename: K M
authors.initials: KM
authors.lastname: Flanigan
mesh_terms: D015938:Complement Membrane Attack Complex / Q000378:metabolism; D005260:Female; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000378:metabolism / Q000473:pathology; D009188:Myelitis, Transverse / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology
chemical_list: D015938:Complement Membrane Attack Complex; D016756:Immunoglobulins, Intravenous