The role of catecholamines in formation and resolution of pulmonary oedema.
Pulmonary oedema (PO) can emerge from mechanical disorders in pulmonary circulation leading to elevated fluid filtration in the lung, or from increased vascular permeability due to inflammatory or toxic injury of the alveolar-capillary barrier. A number of these disorders causing PO is associated with increased catecholamine (CA) levels in plasma and lung tissue and/or increased sympathetic activation such as neurogenic PO, high-altitude PO or PO in patients with phaeochromocytoma. Experimental CA stimulation in animals induced PO after less than one hour of infusion. Both alpha- and beta-adrenergic mechanisms are involved in the pathogenesis but also in the resolution of PO. CAs increase pulmonary capillary pressure and thus, enhance fluid filtration into the pulmonary interstitium. Additionally, by activation of proinflammatory cytokines, they induce pulmonary inflammation that may lead to capillary leak. Finally, they play an important role in the regulation of alveolar fluid clearance. The present paper considers the pathways by which CAs contribute to the development of PO of various origin.
Rassler
Beate
B
Carl-Ludwig-Institute of Physiology, University of Leipzig, Liebigstr. 27, D - 04103 Leipzig, Germany. rasb@medizin.uni-leipzig.de
D000818:Animals; D002395:Catecholamines / Q000502:physiology* / Q000633:toxicity; D004195:Disease Models, Animal; D006801:Humans; D011652:Pulmonary Circulation / Q000187:drug effects; D011654:Pulmonary Edema / Q000139:chemically induced / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy*; D051381:Rats
D002395:Catecholamines