Regioselective ring-opening metathesis-cross metathesis of bridgehead-substituted 7-azanorbornene.
[structure: see text]. In this paper we describe a highly regioselective ring-opening metathesis-cross metathesis (ROM-CM) process between methyl N-Boc-7-azabicyclo[2.2.1]hept-2-en-1-carboxylate, a bridgehead-substituted 7-azanorbornene system, and electron-poor olefins. The reaction opens the way to the synthesis of interesting alpha-amino diacids and pyrrolizinone derivatives that incorporate quaternary stereocenters.
Carreras
J
J
Departamento de Química, Universidad de La Rioja, Grupo de Síntesis Química de La Rioja, UA-CSIC, 26006 Logroño, Spain.
Avenoza
A
A
Busto
J H
JH
Peregrina
J M
JM