title: Antihepatotoxic Principles of Artemisia capillaris Buds1.
abstract: Since an extract of the crude drug "inchinko", the buds of ARTEMISIA CAPILLARIS, showed significant antihepatotoxic activity by means of carbon tetrachloride-induced liver lesion IN VIVO and IN VITRO, the extract was fractionated by monitoring the activity to yield a number of flavonoids and a coumarin (6,7-dimethylesculetin). Antihepatotoxic effects of these constituents were determined by IN VITRO assay methods using carbon tetrachloride- and galactosamine-induced cytotoxicity in primary cultured rat hepatocytes. Some analogues of dimethylesculetin were also assayed for liver-protective activity. Both the antihepatotoxic activity and the dimethylesculetin content in this plant were found to vary markedly with the date of harvesting, which was assumed to be a reason for remarkable variations of the antihepatotoxic activity in commercially available preparations of this crude drug.
authors.affiliation: Pharmaceutical Institute, Tohoku University, Aoba-yama, Sendai 980, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Kiso
authors.forename: S
authors.initials: S
authors.lastname: Ogasawara
authors.forename: K
authors.initials: K
authors.lastname: Hirota
authors.forename: N
authors.initials: N
authors.lastname: Watanabe
authors.forename: Y
authors.initials: Y
authors.lastname: Oshima
authors.forename: C
authors.initials: C
authors.lastname: Konno
authors.forename: H
authors.initials: H
authors.lastname: Hikino