title: Association between hepatitis C virus coinfection and regional adipose tissue volume in HIV-infected men and women.
abstract: OBJECTIVE
  Coinfection with hepatitis C virus (HCV) is reported to be associated with a higher prevalence of lipodystrophy than HIV infection alone. We examine the association between HCV and adipose tissue volume in HIV-infected men and women.
  
  
  METHODS
  Cross-sectional analysis of HIV-infected subjects from the study of Fat Redistribution and Metabolic Change in HIV Infection. MRI measured regional adipose tissue volume. Detectable HCV RNA defined HCV infection.
  
  
  RESULTS
  Twenty percent of 792 men and 26% of 329 women were HIV/HCV-coinfected. HIV/HCV-coinfected and HIV-monoinfected women had similar amounts of subcutaneous adipose tissue (SAT) in the leg, lower trunk, upper trunk, and arm and similar amounts of visceral adipose tissue (VAT). Similar findings were seen in men, except in the leg and VAT. After adjustment, HCV infection remained associated with more leg fat in men (12.2%, 95% confidence interval [CI]: 0.3 to 25.3; P = 0.043). Among those on stavudine, HIV-monoinfected men had less leg fat (-7% effect per year of stavudine use, 95% CI: -9 to -5; P < 0.001); a weaker association was seen in HIV/HCV-coinfected men (-2% effect, 95% CI: -7 to 3; P = 0.45). Indinavir was associated with less leg fat (-4% in HIV-monoinfected men, 95% CI: -6 to -1; P = 0.002; -5% in HIV/HCV-coinfected men, 95% CI: -11 to 2; P = 0.14).
  
  
  CONCLUSIONS
  Our findings suggest that HIV/HCV coinfection is not associated with less SAT in men and women. HCV infection seems to mitigate the loss of leg fat seen in HIV-infected men on stavudine.
authors.affiliation: Department of Medicine, University of California San Francisco and Department of Veterans Affairs Medical Center, San Francisco, CA 94121, USA. ptien@ucsf.edu
authors.forename: Phyllis C
authors.initials: PC
authors.lastname: Tien
authors.forename: Peter
authors.initials: P
authors.lastname: Bacchetti
authors.forename: Barbara
authors.initials: B
authors.lastname: Gripshover
authors.forename: E Turner
authors.initials: ET
authors.lastname: Overton
authors.forename: David
authors.initials: D
authors.lastname: Rimland
authors.forename: Don
authors.initials: D
authors.lastname: Kotler
mesh_terms: D000273:Adipose Tissue / Q000473:pathology*; D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use; D050218:Body Fat Distribution; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D005260:Female; D006678:HIV; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy / Q000473:pathology*; D006526:Hepatitis C / Q000150:complications*; D006801:Humans; D008060:Lipodystrophy / Q000139:chemically induced / Q000150:complications; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D015995:Prevalence; D012367:RNA, Viral / Q000032:analysis; D018119:Stavudine / Q000627:therapeutic use; D050151:Subcutaneous Fat / Q000473:pathology
chemical_list: D019380:Anti-HIV Agents; D012367:RNA, Viral; D018119:Stavudine