title: Correlation between the serum values of soluble intercellular adhesion molecule-1 and total sialic acid levels in patients with breast cancer.
abstract: BACKGROUND
  In this study, we aimed to investigate serum total sialic acid (TSA) and soluble intracellular adhesion molecule-1 (sICAM-1) levels in breast cancer patients to find a correlation with the cancer stage.
  
  
  METHODS
  The parameters from sera of 61 patients with breast cancer were measured. The concentrations of serum sICAM-1 and TSA were measured in serum samples from 61 patients with breast cancer and 25 healthy control subjects using enzyme-linked immunoassay and thiobarbituric acid method.
  
  
  RESULTS
  Mean serum sICAM-1 and TSA levels were significantly higher in the total patient group than in the control group (p < 0.001). Thus, the correlation between TSA and sICAM-1 became more significant in metastatic breast cancer. There were significant positive correlations between TSA and sICAM-1 in stage I+II (r = 0.59, p < 0.05), stage III (r = 0.47, p < 0.05), and stage IV (r = 0.89, p < 0.01), and total patient group (r = 0.56, p < 0.001).
  
  
  CONCLUSIONS
  SerumsICAM-1 and TSA levels were higher in patients with breast cancer, than that of the control group, and also in the metastatic breast cancer group. Significant correlations between serum sICAM-1 and TSA may reflect the similar function of these molecules as adhesion molecules, and their roles in the carcinogenesis of breast cancer as well as metastasis.
authors.affiliation: Department of General Surgery, School of Medicine, Ataturk University Erzurum, Erzurum, Turkey. mbasoglu@hotmail.com
authors.forename: M
authors.initials: M
authors.lastname: Basoglu
authors.forename: S S
authors.initials: SS
authors.lastname: Atamanalp
authors.forename: M I
authors.initials: MI
authors.lastname: Yildirgan
authors.forename: B
authors.initials: B
authors.lastname: Aydinli
authors.forename: G
authors.initials: G
authors.lastname: Ozturk
authors.forename: F
authors.initials: F
authors.lastname: Akcay
authors.forename: D
authors.initials: D
authors.lastname: Oren
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000097:blood* / Q000473:pathology; D016022:Case-Control Studies; D002450:Cell Communication; D005260:Female; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D008875:Middle Aged; D019158:N-Acetylneuraminic Acid / Q000097:blood*
chemical_list: D018799:Intercellular Adhesion Molecule-1; D019158:N-Acetylneuraminic Acid