Synthesis of soluble multivalent glycoconjugates that target the Hc region of botulinum neurotoxin A.
The design, synthesis, and initial inhibitory studies of di- and tetravalent glycoconjugates that target the heavy chain of botulinum neurotoxin A are reported.
Kale
Ramesh R
RR
301 Clifton Court, Department of Chemistry, University of Cincinnati, Cincinnati, OH 45221, USA.
Clancy
Colin M
CM
Vermillion
Rebecca M
RM
Johnson
Eric A
EA
Iyer
Suri S
SS
D015153:Blotting, Western; D019274:Botulinum Toxins, Type A / Q000037:antagonists & inhibitors* / Q000737:chemistry; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D003014:Clostridium botulinum / Q000378:metabolism; D019281:Dimerization; D015195:Drug Design; D006001:Glycoconjugates / Q000737:chemistry*; D008024:Ligands; D008956:Models, Chemical; D008968:Molecular Conformation; D012995:Solubility
D006001:Glycoconjugates; D008024:Ligands; D019274:Botulinum Toxins, Type A