title: Effect of acceptor phosphate buffer pH value on indomethacin release.
abstract: This contribution investigated in vitro release of the antirheumatic drug indomethacin in relation to phosphate buffer pH in the acceptor part of the permeation apparatus. Drug release was studied from a hydrogel containing 3% of hydroxyethyl cellulose and from a cream. UV-spectroscopic evaluations were done after the preparation of the study drugs. Indomethacin release depends on the pH of the acceptor phosphate buffer, the higher pH value the better release.
authors.affiliation: Department of Galenic Pharmacy, Faculty of Pharmacy, Comenius University, Bratislava, Slovak Republic. vercimakova@fpharm.uniba.sk
authors.forename: M
authors.initials: M
authors.lastname: Vercimáková
authors.forename: Z
authors.initials: Z
authors.lastname: Vitková
authors.forename: V
authors.initials: V
authors.lastname: Simunková
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry*; D005079:Excipients; D020100:Hydrogels; D006863:Hydrogen-Ion Concentration; D007213:Indomethacin / Q000737:chemistry*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D005079:Excipients; D020100:Hydrogels; D007213:Indomethacin