Probiotic capsules do not lower plasma lipids in young women and men.
OBJECTIVE
To investigate the effect of probiotic capsules on plasma lipids.


METHODS
A randomized, single-blinded, placebo-controlled, parallel-arm trial.


METHODS
Fifty-five normocholesterolemic subjects ages 18-36 (33 premenopausal women and 22 men).


METHODS
Each subject consumed either three probiotic capsules each containing a total of 10(9) colony-forming units Lactobacillus acidophilus and Bifidobacterium longum and 10-15 mg fructo-oligosaccharide or three placebo capsules daily for 2 months (men) or two menstrual cycles (women). Plasma lipids were measured before and following the intervention (during the early follicular phase for women).


RESULTS
Plasma concentrations of total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol and triglyceride were not altered by consumption of probiotic or placebo capsules and were not different between treatment groups following the intervention.


CONCLUSIONS
These results do not support a beneficial effect of Lactobacillus acidophilus strain DDS-1 and Bifidobacterium longum strain UABL-14 on plasma lipids in normocholesterolemic young women and men.


BACKGROUND
Supported by the Minnesota Agricultural Experiment Station and UAS Laboratories.
Greany
K A
KA
Department of Food Science and Nutrition, University of Minnesota, St Paul, MN 55108, USA.
Bonorden
M J L
MJ
Hamilton-Reeves
J M
JM
McMullen
M H
MH
Wangen
K E
KE
Phipps
W R
WR
Feirtag
J
J
Thomas
W
W
Kurzer
M S
MS
D000293:Adolescent; D000328:Adult; D001644:Bifidobacterium / Q000502:physiology*; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D015169:Colony Count, Microbial; D005260:Female; D006801:Humans; D007779:Lactobacillus acidophilus / Q000502:physiology*; D050356:Lipid Metabolism / Q000187:drug effects; D008055:Lipids / Q000097:blood*; D008297:Male; D009844:Oligosaccharides / Q000494:pharmacology*; D019936:Probiotics; D016037:Single-Blind Method; D014280:Triglycerides / Q000097:blood
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008055:Lipids; D009844:Oligosaccharides; D014280:Triglycerides; C116580:fructooligosaccharide; D002784:Cholesterol