Public data mining shows extended linkage disequilibrium around ADAM33.
BACKGROUND
ADAM33 has been described to be the first positional cloned asthma gene. Consecutive association studies have found inconsistent results. At present no functional relevant variation is being known.


OBJECTIVE
Aim of the study was to test if genes in close physical distance could also be responsible for the observed linkage signal.


METHODS
We downloaded three public single-nucleotide polymorphism (SNP) data sets and tested if linkage disequilibrium extends beyond ADAM33.


RESULTS
Linkage disequilibrium extends upstream to a region including GDNF family receptor alpha (GFRA4), attractin (ATRN) and downstream to sialoadhesin (SN) with a peak recombinatory rate at ADAM33 exon S to V.


CONCLUSIONS
Resequencing of the ADAM33 region including GFRA4, ATRN and SN is expedient.
Wjst
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Institut für Epidemiologie, GSF - Foschungszentrum für Umwelt und Gesundheit, Neuherberg, Germany.
D051722:ADAM Proteins / Q000235:genetics*; D001249:Asthma / Q000235:genetics; D016208:Databases, Factual; D005060:Europe; D051097:Glial Cell Line-Derived Neurotrophic Factor Receptors / Q000235:genetics; D006801:Humans; D015810:Linkage Disequilibrium; D008562:Membrane Glycoproteins / Q000235:genetics; D008565:Membrane Proteins / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D011971:Receptors, Immunologic / Q000235:genetics; D063267:Sialic Acid Binding Ig-like Lectin 1
C492192:ATRN protein, human; C491860:GFRA4 protein, human; D051097:Glial Cell Line-Derived Neurotrophic Factor Receptors; D008562:Membrane Glycoproteins; D008565:Membrane Proteins; D011971:Receptors, Immunologic; C571166:SIGLEC1 protein, human; D063267:Sialic Acid Binding Ig-like Lectin 1; D051722:ADAM Proteins; C450441:ADAM33 protein, human