[Mitomycin C and excimer laser].
Mitomycin C is an antimetabolite agent that blocks DNA and RNA replication and protein synthesis. It has been used in several ophthalmologic areas, and recently as a modulator of corneal wound healing in excimer laser surgeries. A single application of mitomycin C during surface corneal photoablative surgery seems a safe and efficient therapeutic option for eyes with corneal opacity and/or as prophylaxis in eyes with high risk for corneal opacity development. The use of this drug in photoablative surgery should be cautious until long-term safety results have been reported. The present text presents a review about corneal wound healing with the use of mitomycin C.
Wallau
Anelise Dutra
AD
Universidade Federal de São Paulo, São Paulo, SP. anewallau@hotmail.com
Leoratti
Maria Cristina Ventura
MC
Campos
Mauro
M
D000818:Animals; D003315:Cornea / Q000187:drug effects; D003318:Corneal Opacity / Q000517:prevention & control; D006801:Humans; D054018:Lasers, Excimer; D016685:Mitomycin / Q000009:adverse effects / Q000494:pharmacology*; D009216:Myopia / Q000601:surgery*; D019384:Nucleic Acid Synthesis Inhibitors / Q000009:adverse effects / Q000494:pharmacology*; D018903:Photorefractive Keratectomy; D014792:Visual Acuity; D014945:Wound Healing / Q000187:drug effects*
D019384:Nucleic Acid Synthesis Inhibitors; D016685:Mitomycin