Doppler study of splanchnic hemodynamics in Hirschsprung's disease.
BACKGROUND
Doppler studies of splanchnic vessels have demonstrated alteration in blood flow in bowel obstruction and strangulation. The aim of this study was to evaluate hemodynamic changes in celiac artery (CA), superior mesenteric artery (SMA) and inferior mesenteric artery (IMA) using pulsed Doppler sonography (PDS) in Hirschsprung's disease.


METHODS
Fasting splanchnic flowmetry of CA, SMA, and IMA arteries was performed using PDS preoperatively in 13 patients with Hirschsprung's disease and 13 healthy age- and sex-matched controls. Diagnostic workup for Hirschsprung's disease included a barium enema and a rectal biopsy. A primary transanal pull through was performed if the transition zone was at rectosigmoid or midsigmoid. Doppler studies were repeated on the 1st and 7th postoperative day under similar conditions. Mean flow velocity (V(mean)) and the pulsatility index (PI) of the three major vessels was measured.


RESULTS
Patients with Hirschsprung's disease showed increased blood flow velocities in CA, SMA, and IMA (p < 0.001), an increased resistance to blood flow in IMA (p < 0.001) and a decreased resistance to blood flow in CA and SMA (p < 0.005 and p < 0.001, respectively). The blood flow velocity for IMA normalized after resection of the aganglionic segment (r = 0.41, p < 0.005, 95% CI: 45.4-52.7).


CONCLUSIONS
Hirschsprung's diseaseis associated with alterations in splanchnic vessel hemodynamics which are reversible after corrective surgery. Doppler studies may play an important role in the assessment of bowel function after surgery.
Pratap
Akshay
A
Department of Surgery, B.P. Koirala Institute of Health Sciences, Dharan, Nepal. akshay_pratap2000@yahoo.co.in
Tiwari
Awadhesh
A
Shakya
Vikal Chandra
VC
Yadav
Rohit Prasad
RP
Agarwal
Bikash
B
Koirala
Shweta
S
Shekhar Agrawal
Chandra
C
Adhikary
Shailesh
S
Kumar
Anand
A
Agrawal
Amit
A
D001783:Blood Flow Velocity; D016022:Case-Control Studies; D002445:Celiac Artery / Q000502:physiology / Q000503:physiopathology; D005260:Female; D006627:Hirschsprung Disease / Q000000981:diagnostic imaging / Q000503:physiopathology* / Q000601:surgery; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D017537:Mesenteric Artery, Inferior / Q000502:physiology / Q000503:physiopathology; D017538:Mesenteric Artery, Superior / Q000502:physiology / Q000503:physiopathology; D011673:Pulsatile Flow / Q000502:physiology; D012016:Reference Values; D013152:Splanchnic Circulation / Q000502:physiology*; D016896:Treatment Outcome; D018617:Ultrasonography, Doppler, Pulsed