title: A new CAD system for the evaluation of kidney diseases using DCE-MRI.
abstract: Acute rejection is the most common reason of graft failure after kidney transplantation, and early detection is crucial to survive the transplanted kidney function. In this paper, we introduce a new approach for the automatic classification of normal and acute rejection transplants from Dynamic Contrast Enhanced Magnetic Resonance Imaging (DCE-MRI). The proposed algorithm consists of three main steps; the first step isolates the kidney from the surrounding anatomical structures by evolving a deformable model based on two density functions; the first function describes the distribution of the gray level inside and outside the kidney region and the second function describes the prior shape of the kidney. In the second step, a new nonrigid registration approach is employed to account for the motion of the kidney due to patient breathing. To validate our registration approach, we use a simulation of deformations based on biomechanical modelling of the kidney tissue using the finite element method (F.E.M.). Finally, the perfusion curves that show the transportation of the contrast agent into the tissue are obtained from the cortex and used in the classification of normal and acute rejection transplants. Applications of the proposed approach yield promising results that would, in the near future, replace the use of current technologies such as nuclear imaging and ultrasonography, which are not specific enough to determine the type of kidney dysfunction.
authors.affiliation: Computer Vision and Image Processing Laboratory, University of Louisville, Louisville, KY 40292, USA. elbaz@cvip.uofl.edu
authors.forename: Ayman
authors.initials: A
authors.lastname: El-Baz
authors.forename: Rachid
authors.initials: R
authors.lastname: Fahmi
authors.forename: Seniha
authors.initials: S
authors.lastname: Yuksel
authors.forename: Aly A
authors.initials: AA
authors.lastname: Farag
authors.forename: William
authors.initials: W
authors.lastname: Miller
authors.forename: Mohamed A
authors.initials: MA
authors.lastname: El-Ghar
authors.forename: Tarek
authors.initials: T
authors.lastname: Eldiasty
mesh_terms: D000465:Algorithms; D001185:Artificial Intelligence; D003287:Contrast Media; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D007668:Kidney / Q000473:pathology*; D007674:Kidney Diseases / Q000473:pathology*; D010363:Pattern Recognition, Automated / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013382:Subtraction Technique
chemical_list: D003287:Contrast Media