Effect of sodium ferulate on fluidity and morphology of cell membrane in ozone induced lung injury.
OBJECTIVE
To study the effect of sodium ferulate (SF), an active component of Radix Angelica, on lung damage induced by ozone (03).


METHODS
Mice model of lung injury was induced by ozone inhalation and treated with SF. The level of lipid peroxide and microviscosity in alveolar epithelial cell membrane of the mice was determined, and the structural change of lung cells was observed by microscopy.


RESULTS
Ozone could increase the level of malondialdehyde (MDA) and the microviscosity in alveolar epithelial cell membrane, and induce inflammatory changes in morphologic structure. These abnormal changes were improved after SF administration, which was manifested as alleviation of heightened microviscosity, increase of membrane fluidity, as well as the basically normalized pulmonary cellular structure under microscope.


CONCLUSIONS
SF has a preventive effect against oxidized pulmonary injury induced by ozone, the action of which could be through scavenging oxygen free radicals, reducing lipid peroxide production, increasing membranous fluidity and mitigating inflammatory changes in cell structure. sodium ferulate, ozone, malondialdehyde, membranous fluidity, morphology
Wang
De-jun
DJ
Medical College, Yangzhou University, Jiangsu (225001). jgz7718@sina.com
Dai
Xiao-jun
XJ
Xu
Feng
F
Sun
Yun
Y
D000818:Animals; D002462:Cell Membrane / Q000187:drug effects*; D003373:Coumaric Acids / Q000494:pharmacology*; D005260:Female; D016166:Free Radical Scavengers / Q000494:pharmacology*; D008168:Lung / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008297:Male; D008315:Malondialdehyde / Q000032:analysis; D008560:Membrane Fluidity / Q000187:drug effects*; D051379:Mice; D008813:Mice, Inbred ICR; D010126:Ozone / Q000633:toxicity*
D003373:Coumaric Acids; D016166:Free Radical Scavengers; D008315:Malondialdehyde; D010126:Ozone; C004999:ferulic acid