title: [Expression and clinical significance of matrix metalloproteinase-2 in laryngeal squamous cell carcinoma].
abstract: OBJECTIVE
  To investigate the relationship between the expression of matrix metalloproteinase-2 (MMP-2) and clinical significance of laryngeal squamous cell carcinomas (LSCC).
  
  
  METHODS
  Expression of the MMP-2 was detected by immunohistochemical method in 63 cases of LSCC, 20 cases of adjacent safety margin (ASM) and 18 cases of vocal cord polyp (VCP).
  
  
  RESULTS
  The positive percentage of active MMP-2 expression were 66.7%, 33. 3% and 15. 0%, in LSCC,VCP and ASM respectively. Significant differences ( P <0. 05) were observed among the three group; there was a significant differences in the expression of MMP-2 among the different pathologic degree I , II , III; no significant difference in the expression of MMP-2 between lymphoid metastasis and no lymphoid metastasis ( P >0. 05); Age and clinical stage did not change the expressions of the MMP-2 expression ( P <0. 05).
  
  
  CONCLUSIONS
  MMP-2 probably plays an important role in the carcinogenesis and progression of LSCC. But it may be an unnecessary factor in the metastases of LSCC.
authors.affiliation: Department of Otorhinolaryngology, the People' s Hospital of Guangdong Province, Guangzhou, 510630, China.
authors.forename: Xiaoqian
authors.initials: X
authors.lastname: Wang
authors.forename: Yanchun
authors.initials: Y
authors.lastname: Shan
authors.forename: Jiqun
authors.initials: J
authors.lastname: Wang
authors.forename: Sijin
authors.initials: S
authors.lastname: Luo
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D020778:Matrix Metalloproteinase 2 / Q000378:metabolism*; D008875:Middle Aged; D009367:Neoplasm Staging
chemical_list: C522361:MMP2 protein, human; D020778:Matrix Metalloproteinase 2