[Bronchopulmonary aminochlorthenoxycycline levels in experimental burns of the respiratory tree].
A special technique was employed to obtain burns of the respiratory tree in 24 male rabbits, Increased bronchial secretion was observed during the burning. Aminochlorthenoxycycline values were higher in the secretion after 90' than in the controls, while blood and lung concentrations displayed a similar pattern. The usefulness of the drug in the prevention and treatment of infectious complications following burns in this area is stressed.
Rognoni
F
F
Istituto Chemioterapico Italiano (San Grato di Lodi).
Ariano
M
M
Lucca
L
L
D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000032:analysis / Q000493:pharmacokinetics*; D048588:Benzoxazines; D001980:Bronchi / Q000737:chemistry / Q000187:drug effects / Q000293:injuries* / Q000378:metabolism; D002059:Burns, Inhalation / Q000188:drug therapy* / Q000378:metabolism; D004353:Drug Evaluation, Preclinical; D005122:Exudates and Transudates / Q000737:chemistry; D007273:Injections, Intramuscular; D008168:Lung / Q000737:chemistry / Q000187:drug effects; D055370:Lung Injury; D008297:Male; D010078:Oxazines / Q000008:administration & dosage / Q000032:analysis / Q000493:pharmacokinetics*; D011817:Rabbits; D012141:Respiratory Tract Infections / Q000209:etiology / Q000517:prevention & control
D000900:Anti-Bacterial Agents; D048588:Benzoxazines; D010078:Oxazines; C002856:aminochlorthenoxazine