title: Natural history and long-term follow-up of antenatally detected liver cysts.
abstract: OBJECTIVE
  Antenatally detected liver cysts are rare; their diagnostic accuracy is unknown, and their management is controversial. This study assessed the natural history of these lesions.
  
  
  METHODS
  We conducted a retrospective review of infants with isolated intrahepatic cysts that were detected antenatally. Data are expressed as median (range).
  
  
  RESULTS
  Fifteen infants presented during the period 1991-2004 with an antenatally detected liver cyst. Their gestational age at detection was 22 (18-34) weeks, and the maximum diameter of their cyst was 23 (10-120) mm. Serial scans, which were performed in 9 fetuses, showed cyst enlargement in 5 cases, diminution in 1 case, and no change in 3 cases. In utero percutaneous aspiration was required in 1 infant. Three infants underwent postnatal surgery. One fetus (postfetal intervention) had a subtotal excision of a large subcapsular cyst filling the abdominal cavity on day 2. Another infant required partial excision and marsupialization (complex cyst arising from segment IV) at 5 months, and a third infant underwent a cyst cholecystostomy at 4 months. Postnatal investigations (including hepatic scintigraphy) suggested that the remaining lesions were either simple parenchymal (n = 10) or isolated intrahepatic choledochal (ie, type V; n = 2) cysts. The median follow-up for these patients was 44 (27-167) months. Serial postnatal ultrasonography showed cyst diminution in 4 cases, an enlargement in 1 case, and no dimensional change in 7 cases.
  
  
  CONCLUSIONS
  Most antenatally detected liver cysts appear to be simple and of parenchymal origin and do not require fetal intervention. Their postnatal history is variable, but regression without treatment is seen in most cases.
authors.affiliation: Department of Pediatric Surgery, King's College Hospital, London, Denmark Hill, London SE5 9RS, United Kingdom.
authors.forename: Paul
authors.initials: P
authors.lastname: Charlesworth
authors.forename: Niyi
authors.initials: N
authors.lastname: Ade-Ajayi
authors.forename: Mark
authors.initials: M
authors.lastname: Davenport
mesh_terms: D003560:Cysts / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000628:therapy; D018450:Disease Progression; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008107:Liver Diseases / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000628:therapy; D008297:Male; D012189:Retrospective Studies; D016216:Ultrasonography, Prenatal