Spin coherence transfer in chemical transformations monitored by remote detection NMR.
We demonstrate a nuclear magnetic resonance (NMR) experiment using continuous flow in a microfluidic channel for studying the transfer of spin coherence in nonequilibrium chemical processes. We use the principle of remote detection, which involves spatially separated NMR encoding and detection coils. As an example, we provide the map of chemical shift correlations for the amino acid alanine as it transitions from the zwitterionic to the anionic form. The presented method uniquely allows for tracking the migration of encoded spins during the course of any chemical transformation and can provide useful information about reaction mechanisms.
Anwar
M Sabieh
MS
Department of Chemistry, University of California, Berkeley and Division of Materials Science, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Building 11-D64, Berkeley, California 94720, USA. sabieh@berkeley.edu
Hilty
Christian
C
Chu
Chester
C
Bouchard
Louis-S
LS
Pierce
Kimberly L
KL
Pines
Alexander
A