The Development of rapamycin as an orphan drug.
Hidalgo
Manuel
M
Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD 21201, USA.
D017321:Clinical Trials, Phase I as Topic; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008297:Male; D009965:Orphan Drug Production / Q000379:methods*; D010190:Pancreatic Neoplasms / Q000188:drug therapy*; D011494:Protein Kinases / Q000187:drug effects; D020123:Sirolimus / Q000008:administration & dosage* / Q000627:therapeutic use; D058570:TOR Serine-Threonine Kinases; D016896:Treatment Outcome
D011494:Protein Kinases; C546842:MTOR protein, human; D058570:TOR Serine-Threonine Kinases; D020123:Sirolimus