title: [Pre-hospital thrombolytic therapy].
abstract: Reperfusion therapy with intravenous thrombolytic agents in acute ST-segment elevation myocardial infarction reduces the infarct size, preserves ventricular function, and therefore reduces mortality. Experimental and clinical studies also showed that time to successful reperfusion is a critical determinant of survival. In this paper the importance of very early (pre-hospital) thrombolysis, its comparison with percutaneous interventional therapy and the feasibility in Turkey are discussed. Although primary coronary interventions are preferred in patients with ST-segment elevation myocardial infarction intravenous, early bolus thrombolysis in the pre-hospital stage provides a therapeutic option as good as primary angioplasty. Until necessary policy and technical substructure are completed cardiology centers should apply the most suitable reperfusion strategy according with the guidelines, feasibilities and their experience.
authors.affiliation: Department of Cardiology, Medical Faculty, Ege University, Izmir, Turkey. mehdi_zoghi@hotmail.com
authors.forename: Mehdi
authors.initials: M
authors.lastname: Zoghi
mesh_terms: D004632:Emergency Medical Services / Q000706:statistics & numerical data*; D004638:Emergency Treatment; D005343:Fibrinolytic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007262:Infusions, Intravenous; D009203:Myocardial Infarction / Q000188:drug therapy*; D015912:Thrombolytic Therapy; D014421:Turkey
chemical_list: D005343:Fibrinolytic Agents