title: n-3 Fatty acids are positively associated with peak bone mineral density and bone accrual in healthy men: the NO2 Study.
abstract: BACKGROUND
  Knowledge of the influence of nutritional intake on bone health is limited. Polyunsaturated fatty acids have been suggested to influence bone growth and modeling in humans, although data are sparse.
  
  
  OBJECTIVE
  The objective was to investigate the role of fatty acids in bone accumulation and the attainment of peak bone mass in young men.
  
  
  METHODS
  The cohort studied consisted of 78 healthy young men with a mean age of 16.7 y at baseline. Bone mineral density (BMD; in g/cm(2)) of total body, hip, and spine was measured at baseline and at 22 and 24 y of age. Fatty acid concentrations were measured in the phospholipid fraction in serum at 22 y of age.
  
  
  RESULTS
  Concentrations of n-3 fatty acids were positively associated with total BMD (r = 0.27, P = 0.02) and spine BMD (r = 0.25, P = 0.02) at 22 y of age. A positive correlation between n-3 fatty acid concentrations and the changes in BMD at the spine (r = 0.26, P = 0.02) was found between 16 and 22 y of age. Concentrations of docosahexaenoic acid (DHA, 22:6n-3) were positively associated with total BMD (r = 0.32, P = 0.004) and BMD at the spine (r = 0.30, P = 0.008) at 22 y of age. A positive correlation was also found between DHA concentrations and the changes in BMD at the spine (r = 0.26, P = 0.02) between 16 and 22 y of age.
  
  
  CONCLUSIONS
  The results showed that n-3 fatty acids, especially DHA, are positively associated with bone mineral accrual and, thus, with peak BMD in young men.
authors.affiliation: Sports Medicine, Department of Surgical and Perioperative Science, Umeå University, Umeå, Sweden.
authors.forename: Magnus
authors.initials: M
authors.lastname: Högström
authors.forename: Peter
authors.initials: P
authors.lastname: Nordström
authors.forename: Anna
authors.initials: A
authors.lastname: Nordström
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D015519:Bone Density / Q000187:drug effects; D001842:Bone and Bones / Q000187:drug effects / Q000502:physiology*; D015331:Cohort Studies; D004032:Diet; D015444:Exercise; D005227:Fatty Acids / Q000097:blood; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage / Q000494:pharmacology*; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D010743:Phospholipids / Q000097:blood*; D012016:Reference Values; D013997:Time Factors
chemical_list: D005227:Fatty Acids; D015525:Fatty Acids, Omega-3; D010743:Phospholipids