Estrogen receptor beta gene +1730 G/A polymorphism in women with endometriosis.
OBJECTIVE
To investigate whether the +1730 G/A polymorphism of the estrogen receptor beta (ER-beta) gene is associated with the risk of endometriosis in a Korean population.


METHODS
Case-control study.


METHODS
University Department of Obstetrics and Gynecology.


METHODS
Women with (n = 239) or without (n = 287) endometriosis.


METHODS
The +1730 G/A polymorphism of 3'-UTR of exon 8 in the ER-beta gene was assessed by polymerase chain reaction-restriction fragment-length polymorphism analysis utilizing digestion with AluI restriction enzyme.


METHODS
Genotype distribution and allele frequency of the +1730 G/A polymorphism in the ER-beta gene.


RESULTS
The genotype distribution of the +1730 G/A polymorphism in the ER-beta gene was not different between the endometriosis patients and the controls (G/G of 74.9% vs. 72.5%, G/A of 25.1% vs. 26.1%, and A/A of 0.0% vs. 1.4%, respectively). There was also no difference in the G and A allele frequencies between the two groups (87.4% vs. 85.5%, and 12.6% vs. 14.5%, respectively). Even when the endometriosis cases were subdivided into American Society for Reproductive Medicine stage I-II, III, IV, and III-IV, no differences were found at all in the genotype distribution or allele frequencies between the two groups.


CONCLUSIONS
Our results suggest that the +1730 G/A polymorphism of the ER-beta gene may not be associated with the risk of endometriosis in the Korean population, which was not the case in the Japanese population.
Lee
Gyoung Hoon
GH
Department of Obstetrics and Gynecology, Medical Research Center, Seoul National University College of Medicine, Seoul, Korea.
Kim
Sung Hoon
SH
Choi
Young Min
YM
Suh
Chang Suk
CS
Kim
Jung Gu
JG
Moon
Shin Yong
SY
D000328:Adult; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D004715:Endometriosis / Q000453:epidemiology / Q000235:genetics*; D047629:Estrogen Receptor beta / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D006801:Humans; D007723:Korea / Q000453:epidemiology; D011110:Polymorphism, Genetic
D047629:Estrogen Receptor beta