title: Comparison of glaucoma progression evaluated with Heidelberg retina tomograph II versus optic nerve head stereophotographs.
abstract: BACKGROUND
  To compare disease progression in glaucoma evaluated by means of the Heidelberg retina tomograph (HRT II) or by expert clinical assessment of colour stereophotographs of the optic nerve head (ONH).
  
  
  METHODS
  One eye each of 54 subjects with glaucoma was reviewed using the HRT II and ONH stereophotographs. The ONH stereophotographs were assessed twice each for glaucomatous progression by 2 expert observers (Drs. Buys and Trope). They were considered to be in agreement if their results were the same in 3 of 4 assessments. Progression on the HRT II was defined by using the topographic change analysis (TCA). The clinical assessments were the reference standard used to determine sensitivity and specificity of the HRT II TCA.
  
  
  RESULTS
  The expert observers were in agreement in 50 subjects (92%). Concordance between the HRT II and ONH stereophotographs assessments was obtained in 35 patients (65%); 16 patients (30%) showed progression on HRT II only, while 3 patients (6%) showed progression on stereophotographs only. When these results were used to perform a post hoc analysis, HRT II sensitivity increased from 70% to 78% and specificity increased from 63.6% to 70%. The positive predictive value of the HRT II rose from 30.4% to 47.8%, while the negative predictive value remained at 90.3%.
  
  
  CONCLUSIONS
  Our results demonstrate only fair agreement between HRT II and clinical judgment of ONH stereophotographs for progression in glaucomatous eyes. At present, HRT II progression alone should not indicate a treatment change. HRT II change must be evaluated in conjunction with other clinical features of deterioration before altering therapy.
authors.affiliation: Department of Ophthalmology, Toronto Western Hospital, University Health Network, Ontario, Canada.
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Kourkoutas
authors.forename: Yvonne M
authors.initials: YM
authors.lastname: Buys
authors.forename: John G
authors.initials: JG
authors.lastname: Flanagan
authors.forename: Wendy V
authors.initials: WV
authors.lastname: Hatch
authors.forename: Carmen
authors.initials: C
authors.lastname: Balian
authors.forename: Graham E
authors.initials: GE
authors.lastname: Trope
mesh_terms: D000328:Adult; D000368:Aged; D003941:Diagnostic Techniques, Ophthalmological; D018450:Disease Progression; D005189:False Positive Reactions; D005260:Female; D005901:Glaucoma / Q000175:diagnosis*; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D008875:Middle Aged; D009798:Ocular Hypertension / Q000175:diagnosis; D009898:Optic Disk / Q000473:pathology*; D009901:Optic Nerve Diseases / Q000175:diagnosis*; D010781:Photography / Q000379:methods; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D014054:Tomography / Q000379:methods