Derivative-ratio spectrophotometric method for the determination of ternary mixture of aspirin, paracetamol and salicylic acid.
A derivative spectrophotometric method was developed for the assay of a ternary mixture of aspirin (ASP), paracetamol (PAR) and salicylic acid (SAL). The method is based on the use of the first and second derivatives of the ratio spectra and measurement at zero-crossing wavelengths. The ratio spectra were obtained by dividing the absorption spectrum of the mixture by that of one of the components. The concentration of the other components are then determined from their respective calibration curves treated similarly. The described method was applied for the determination of these combinations in synthetic mixtures and dosage forms. The results obtained were accurate and precise.
El-Yazbi
Fawzi A
FA
Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Beirut Arab University, Lebanon.
Hammud
Hassan H
HH
Assi
Sulaf A
SA
D000082:Acetaminophen / Q000032:analysis*; D001241:Aspirin / Q000032:analysis*; D004338:Drug Combinations; D020156:Salicylic Acid / Q000032:analysis*; D013053:Spectrophotometry / Q000379:methods*; D013056:Spectrophotometry, Ultraviolet / Q000379:methods
D004338:Drug Combinations; D000082:Acetaminophen; D020156:Salicylic Acid; D001241:Aspirin