title: Segmentation of thalamic nuclei from DTI using spectral clustering.
abstract: Recent work shows that diffusion tensor imaging (DTI) can help resolving thalamic nuclei based on the characteristic fiber orientation of the corticothalamic/thalamocortical striations within each nucleus. In this paper we describe a novel segmentation method based on spectral clustering. We use Markovian relaxation to handle spatial information in a natural way, and we explicitly minimize the normalized cut criteria of the spectral clustering for a better optimization. Using this modified spectral clustering algorithm, we can resolve the organization of the thalamic nuclei into groups and subgroups solely based on the voxel affinity matrix, avoiding the need for explicitly defined cluster centers. The identification of nuclear subdivisions can facilitate localization of functional activation and pathology to individual nuclear subgroups.
authors.affiliation: MIT Computer Science and Artificial Intelligence Lab, Cambridge MA, USA. ulas@mit.edu
authors.forename: Ulas
authors.initials: U
authors.lastname: Ziyan
authors.forename: David
authors.initials: D
authors.lastname: Tuch
authors.forename: Carl-Fredrik
authors.initials: CF
authors.lastname: Westin
mesh_terms: D000465:Algorithms; D001185:Artificial Intelligence; D016000:Cluster Analysis; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D010363:Pattern Recognition, Automated / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013787:Thalamic Nuclei / Q000033:anatomy & histology*