HHV-8 positive Kaposi sarcoma in a patient with end-stage renal disease undergoing hemodialysis: no regressive effect of captopril.
Human herpesvirus 8 (HHV-8) has been associated with Kaposi sarcoma (KS) in renal transplant recipients. On the other hand, there are only a few reported cases of KS in patients with end stage renal failure receiving hemodialysis. Here, we report a case of HHV-8 positive, disseminated KS, in a 70-year-old man with renal failure, receiving hemodialysis for 7 months. The KS lesions had begun to develop almost at the same time with the onset of dialysis. The patient had been on captopril therapy since the diagnosis of renal failure. Captopril has been reported to inhibit angiogenesis, and by this way, to reduce tumor growth. However, in our patient, the lesions had developed under the treatment of captopril, and showed no evidence of regression after withdrawal of the drug.
Yaşar
Sirin
S
Haydarpaşa Numune Training and Research Hospital Department of Dermatology, 34668 Istanbul, Turkey.
Mansur
Ayse Tülin
AT
Göktay
Fatih
F
Aydingöz
Ikbal Esen
IE
D000368:Aged; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D002216:Captopril / Q000627:therapeutic use; D003937:Diagnosis, Differential; D019288:Herpesvirus 8, Human; D006801:Humans; D007676:Kidney Failure, Chronic / Q000188:drug therapy / Q000628:therapy*; D008297:Male; D006435:Renal Dialysis; D012514:Sarcoma, Kaposi / Q000175:diagnosis* / Q000473:pathology / Q000821:virology; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000821:virology; D017211:Treatment Failure
D000806:Angiotensin-Converting Enzyme Inhibitors; D002216:Captopril