The anaesthetic and intensive care of status epilepticus.
OBJECTIVE
Status epilepticus refractory to first and second-line anticonvulsants represents an outstanding challenge to the medical team. This review covers new insights into the anaesthetic and intensive care of status epilepticus.


RESULTS
In the anaesthetic treatment of status epilepticus, barbiturates, midazolam, or propofol are the drugs of choice, but the lack of controlled prospective data as yet does not allow the recommendation of a preference for one of the substances, unequivocally. Recent observational studies reported on inhalational anaesthetics and supplementary nonanaesthetics such as levetiracetam or topiramate that may be administered if status epilepticus is not controlled by intravenous anaesthetics. Nonpharmacological approaches including resective surgery, brain stimulation, and hypothermia may be applied in selected patients, only. Psychogenic nonepileptic status epilepticus commonly mimics refractory generalized convulsive status epilepticus, and clinical features discerning the two conditions are presented. The underlying cause is the major contributor for a difficult-to-treat 'malignant' course of status epilepticus and together with age determines mortality and functional outcome.


CONCLUSIONS
The common substances administered for the anaesthetic treatment of status epilepticus require assessment in a prospective randomized controlled trial. Alternative pharmacological or nonpharmacological approaches need further studies as well before they can be recommended as part of the therapeutic regime.
Holtkamp
Martin
M
Department of Neurology, Charité Universitätsmedizin Berlin, Berlin, Germany. martin.holtkamp@charite.de
D000777:Anesthetics / Q000627:therapeutic use*; D003422:Critical Care; D006801:Humans; D013226:Status Epilepticus / Q000188:drug therapy* / Q000503:physiopathology
D000777:Anesthetics