Towards a statistical atlas of cardiac fiber structure.
We propose here a framework to build a statistical atlas of diffusion tensors of canine hearts. The anatomical images of seven hearts are first non-rigidly registered in the same reference frame and their associated diffusion tensors are then transformed with a method that preserves the cardiac laminar sheets. In this referential frame, the mean tensor and its covariance matrix are computed based on the Log-Euclidean framework. With this method, we can produce a smooth mean tensor field that is suited for fiber tracking algorithms or the electromechanical modeling of the heart. In addition, by examining the covariance matrix at each voxel it is possible to assess the variability of the cardiac fiber directions and of the orientations of laminar sheets. The results show a strong coherence of the diffusion tensors and the fiber orientations among a population of seven normal canine hearts.
Peyrat
Jean-Marc
JM
INRIA, Asclepios Research Project, Sophia Antipolis, France. jean-marc.peyrat@sophia.inria.fr
Sermesant
Maxime
M
Pennec
Xavier
X
Delingette
Hervé
H
Xu
Chenyang
C
McVeigh
Elliot
E
Ayache
Nicholas
N
D000465:Algorithms; D000716:Anatomy, Artistic / Q000379:methods; D000818:Animals; D003198:Computer Simulation; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D004285:Dogs; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008488:Medical Illustration; D008953:Models, Anatomic; D008955:Models, Cardiovascular; D015233:Models, Statistical; D018485:Muscle Fibers, Skeletal / Q000166:cytology*; D009206:Myocardium / Q000166:cytology*; D010363:Pattern Recognition, Automated / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity