Histological changes in parts of foregut of rat after indomethacin administration.
BACKGROUND
Indomethacin, a non-steriodalanti-inflammatory drug, is used mainly for the treatment of painful joints such as rehumatoid arthritis, osteo-arhtritis, gout, ankylosing spondylitis etc. It relieves pain, reduces swelling and tenderness of the joints. It also induces ulceration of stomach and small intestine both in experimental animals and humans.


METHODS
In this study indomethacin was given intrapertioneally in maximum therapeutic dose (4 mg/Kg body weight) to three experimental groups B, C and D for one, two and three weeks respectively. Group A was the control group.


RESULTS
Effects were observed in stomach pylorus and proximal duodenum. In the stomach pylorus, well defined superficial ulcers were identified during initial two weeks of drug administration. The ulcer penetrated as for as muscularis mucosae and ulcer bed had coagulative necrosis and inflammatory cells. During third week, stomach pylorus showed minor damage in the form of focal necrosis. Duodenum was affected less than stomach and showed villi with lost tips, tilted and distorted villi. Morphometric analysis showed changes in stomach pylorus and in duodenum. The number of mitotic figure was significantly increased in stomach pylorus. Duodenum showed insignificant to significant decrease in the height of villi. Increase in the number of goblet cells, columnar cells, and mitotic figure was also noted; which was undoubtedly part of the tissue response to an injury.


CONCLUSIONS
These observations suggested that indomethacin given in a maximum therapeutic dose, initially induces lesions in stomach pylorus and proximal duodenum but almost no effects were noted when duration of the drug administration was prolonged.
Ilahi
Maqbool
M
Department of Anatomy, Khyber Girls Medical College Peshawar, Pakistan.
Khan
Jehanzeb
J
Inayat
Qaiser
Q
Abidi
Tuqqaya Sultana
TS
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000494:pharmacology*; D004334:Drug Administration Schedule; D004386:Duodenum / Q000187:drug effects* / Q000473:pathology*; D007213:Indomethacin / Q000008:administration & dosage / Q000494:pharmacology*; D011708:Pylorus / Q000187:drug effects* / Q000473:pathology*; D051381:Rats; D017208:Rats, Wistar
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007213:Indomethacin