title: Prevalence and characteristics of a family history of end-stage renal disease among adults in the United States population: Reasons for Geographic and Racial Differences in Stroke (REGARDS) renal cohort study.
abstract: This report describes the prevalence and characteristics of people with a family history of ESRD in a first-degree relative (FH-ESRD). This is a cross-sectional study of individuals in the Reasons for Geographic and Racial Differences in Stroke (REGARDS) cohort, a population-based sample of US residents who are 45 yr and older. FH-ESRD was ascertained at baseline among 12,030 participants of the cohort, and multivariate logistic regression was used to identify characteristics that were independently associated with FH-ESRD. FH-ESRD was reported by 9.5% of participants. Individual characteristics that were independently associated with FH-ESRD included black race (odds ratio [OR] 2.14; 95% confidence interval [CI] 1.82 to 2.53); female gender (OR 1.28; 95% CI 1.08 to 1.51); a history of diabetes (OR 1.22; 95% CI 1.02 to 1.47); a 1-SD change in the log of the C-reactive protein level (OR 1.10; 95% CI 1.01 to 1.19); and World Health Organization body mass index weight categories normal (OR 2.11; 95% CI 0.66 to 6.79), overweight (OR 2.64; 95% CI 0.82 to 8.42), and obese (OR 3.48; 95% CI 1.09 to 11.1) compared with underweight. Black but not white individuals with FH-ESRD were more likely to have an estimated GFR <60 ml/min per 1.73 m(2). There is a high prevalence of FH-ESRD among US adults, and the prevalence of FH-ESRD was higher among lack individuals. Individuals with a positive family history were more likely to have diabetes and to be obese. If confirmed, then these findings suggest that individuals with FH-ESRD may benefit from interventions to improve the detection and treatment of chronic kidney disease risk factors such as diabetes and obesity.
authors.affiliation: Georgia Medical Care Foundation, Emory University, Suite 200, Executive Park South NE, Atlanta, GA 30329-2224, USA. wmcclel@sph.emory.edu
authors.forename: William
authors.initials: W
authors.lastname: McClellan
authors.forename: Rebecca
authors.initials: R
authors.lastname: Speckman
authors.forename: Leslie
authors.initials: L
authors.lastname: McClure
authors.forename: Virginia
authors.initials: V
authors.lastname: Howard
authors.forename: Ruth C
authors.initials: RC
authors.lastname: Campbell
authors.forename: Mary
authors.initials: M
authors.lastname: Cushman
authors.forename: Paul
authors.initials: P
authors.lastname: Audhya
authors.forename: George
authors.initials: G
authors.lastname: Howard
authors.forename: David G
authors.initials: DG
authors.lastname: Warnock
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000032:analysis; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D005190:Family; D005260:Female; D005919:Glomerular Filtration Rate; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000453:epidemiology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012709:Serum Albumin / Q000032:analysis; D020521:Stroke / Q000453:epidemiology* / Q000208:ethnology; D014481:United States / Q000453:epidemiology
chemical_list: D006454:Hemoglobins; D012709:Serum Albumin; D002097:C-Reactive Protein