Implication of EMT induced by TGF-beta1 in pancreatic cancer.
This study examined the implication of EMT induced by TGF-beta1 in pancreatic cancer invasion. TGF-beta1 expression was determined in 29 cases of human pancreatic carcinoma (PC) by immunohistochemistry and the results were compared with those of pathological examination. Moreover, the effects of TGF-beta1 on the phenotype and invasion of pancreatic cancer cell line Panc-1 were also investigated. TGF-beta1 was detected in 12 cases (41.4%) of PC. Significant correlation was found between the expression of TGF-beta1 and lymph node involvement (P=0.047) and the depth of invasion (P=0.035). TGF-beta1 obviously promoted EMT of Panc-1 cell lines and their invasion ability was substantially enhanced. TGF-beta1 may promote the malignancy of pancreatic cancer by triggering EMT.
Yin
Tao
T
Pancreatic Center Department of General Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Wang
Chunyou
C
Liu
Tao
T
Zhao
Gang
G
Zhou
Feng
F
D045744:Cell Line, Tumor; D058750:Epithelial-Mesenchymal Transition / Q000187:drug effects*; D006801:Humans; D010190:Pancreatic Neoplasms / Q000473:pathology*; D053773:Transforming Growth Factor beta1 / Q000494:pharmacology*
D053773:Transforming Growth Factor beta1