title: Simulation of acquisition artefacts in MR scans: effects on automatic measures of brain atrophy.
abstract: Automatic algorithms in conjunction with longitudinal MR brain images can be used to measure cerebral atrophy, which is particularly pronounced in several types of dementia. An atrophy simulation technique has been devised to facilitate validation of these algorithms. To make this model of atrophy more realistic we simulate acquisition artefacts which are common problems in dementia imaging: motion (both step and periodic motion) and pulsatile flow artefact. Artefacts were simulated by combining different portions of k-space from various modified image. The original images were 7 MR scans of healthy elderly controls, each of which had two levels of simulated atrophy. We investigate the effect of the simulated acquisition artefacts in atrophy measurements provided by an automatic technique, SIENA.
authors.affiliation: Center of Medical Image Computing, University College of London, UK. o.camara-rey@ucl.ac.uk
authors.forename: Oscar
authors.initials: O
authors.lastname: Camara-Rey
authors.forename: Beatrix I
authors.initials: BI
authors.lastname: Sneller
authors.forename: Gerard R
authors.initials: GR
authors.lastname: Ridgway
authors.forename: Ellen
authors.initials: E
authors.lastname: Garde
authors.forename: Nick C
authors.initials: NC
authors.lastname: Fox
authors.forename: Derek L G
authors.initials: DL
authors.lastname: Hill
mesh_terms: D000465:Algorithms; D016477:Artifacts; D001185:Artificial Intelligence; D001284:Atrophy / Q000473:pathology; D001921:Brain / Q000473:pathology*; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008959:Models, Neurological; D010363:Pattern Recognition, Automated / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity