title: Probing nucleoid structure in bacteria using phage lambda integrase-mediated chromosome rearrangements.
abstract: Conservative site-specific recombination has been adapted for a multitude of uses, in both prokaryotes and eukaryotes, including genetic engineering, expression technologies, and as probes of chromosome structure and organization. In this article, we give a specific example of the latter application, and a quick summary of some of the myriad other genetic and biotechnology applications of site-specific recombination.
authors.affiliation: Department of Biology, San Diego State University, San Diego, CA, USA.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Garcia-Russell
authors.forename: Samantha S
authors.initials: SS
authors.lastname: Orchard
authors.forename: Anca M
authors.initials: AM
authors.lastname: Segall
mesh_terms: D010582:Bacteriophage lambda / Q000201:enzymology* / Q000235:genetics*; D002876:Chromosomes, Bacterial; D019426:Integrases / Q000378:metabolism*
chemical_list: D019426:Integrases