title: [Leydig cell tumor as a cause of hirsutism in a postmenopausal woman].
abstract: BACKGROUND
  Hirsutism or virilization in postmenopausal women may be due to increased testosterone levels caused by an androgen-secreting tumor. The preoperative localization of small ovarian or adrenal androgen-secreting tumors is difficult.
  
  
  METHODS
  A 61-year-old, postmenopausal woman presented with progressive hirsutism and deepening of voice over the last 9 years. Serum testosterone was very high (almost 30 nmol/l). Computed tomographic (CT) scans of the adrenals and ultrasonography of the pelvis were negative. Selective catheterization and [(18)F]FDG-PET/CT investigation raised the suspicion of an androgen-secreting tumor of the right ovary. Oophorectomy was performed, and a Leydig cell tumor of the right ovary was confirmed on histological examination.
  
  
  CONCLUSIONS
  Selective catheterization and [(18)F]FDG-PET investigation may aid the detection of androgen-secreting tumors.
authors.affiliation: Klinik für Endokrinologie, Universitätsklinikum Essen, Essen, Deutschland. anna.matuszczyk@gmx.de
authors.forename: Anna
authors.initials: A
authors.lastname: Matuszczyk
authors.forename: Stephan
authors.initials: S
authors.lastname: Petersenn
authors.forename: Harald
authors.initials: H
authors.lastname: Lahner
authors.forename: Michael
authors.initials: M
authors.lastname: Haude
authors.forename: Patrick
authors.initials: P
authors.lastname: Veit
authors.forename: Jan U
authors.initials: JU
authors.lastname: Becker
authors.forename: Rainer
authors.initials: R
authors.lastname: Kimmig
authors.forename: Andreas
authors.initials: A
authors.lastname: Bockisch
authors.forename: Klaus
authors.initials: K
authors.lastname: Mann
mesh_terms: D005260:Female; D019788:Fluorodeoxyglucose F18; D012739:Gonadal Steroid Hormones / Q000097:blood; D006628:Hirsutism / Q000097:blood / Q000209:etiology* / Q000473:pathology; D006801:Humans; D007984:Leydig Cell Tumor / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D010053:Ovary / Q000473:pathology; D049268:Positron-Emission Tomography; D013739:Testosterone / Q000097:blood* / Q000378:metabolism
chemical_list: D012739:Gonadal Steroid Hormones; D019788:Fluorodeoxyglucose F18; D013739:Testosterone