Radiation-induced DNA damage responses.
The amazing feature of ionising radiation (IR) as a DNA damaging agent is the range of lesions it induces. Such lesions include base damage, single strand breaks (SSBs), double strand breaks (DSBs) of varying complexity and DNA cross links. A range of DNA damage response mechanisms operate to help maintain genomic stability in the face of such damage. Such mechanisms include pathways of DNA repair and signal transduction mechanisms. Increasing evidence suggests that these pathways operate co-operatively. In addition, the relative impact of one mechanism over another most probably depends upon the cell cycle phase and tissue type. Here, the distinct damage response pathways are reviewed and the current understanding of the interplay between them is considered. Since DNA DSBs are the major lethal lesion induced by IR, the focus lies in the mechanisms responding to direct or indirectly induced DSBs.
Jeggo
Penny
P
GDSC University of Sussex, Sussex BN1 9RQ, UK. p.a.jeggo@sussex.ac.uk
Löbrich
Markus
M
D004247:DNA / Q000235:genetics* / Q000528:radiation effects*; D004249:DNA Damage / Q000235:genetics*; D008957:Models, Genetic; D011995:Recombination, Genetic / Q000235:genetics* / Q000528:radiation effects*; D015398:Signal Transduction / Q000235:genetics* / Q000528:radiation effects*
D004247:DNA