Novel aspects of vitamin C: how important is glypican-1 recycling?
The reduced form of vitamin C, ascorbic acid, is well known for its function as an antioxidant and as a protective agent against scurvy. However, many recent studies indicate other functions for vitamin C in mammalian cells. Novel findings provide possible explanations for observed beneficial effects of a high intake of vitamin C on cell growth, gene transcription, host resistance to infection, uptake of polyamines and clearance of misfolded proteins. Vitamin C exerts its effects indirectly via hypoxia-inducible factor, nitric oxide synthase and the heparan sulfate proteoglycan glypican-1, which is deglycanated in a vitamin C- and copper-dependent reaction.
Fransson
Lars-Ake
LA
Department of Experimental Medical Science, Division of Neuroscience, Glycobiology Group, Biomedical Centre A13, Lund University, Lund, Sweden. lars-ake@fransson@med.lu.se
Mani
Katrin
K
D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology; D001205:Ascorbic Acid / Q000008:administration & dosage / Q000378:metabolism* / Q000494:pharmacology*; D053673:Glypicans / Q000378:metabolism*; D006801:Humans; D008954:Models, Biological; D009569:Nitric Oxide / Q000378:metabolism; D009751:Nutritional Requirements; D010100:Oxygen / Q000378:metabolism
D000975:Antioxidants; D053673:Glypicans; D009569:Nitric Oxide; D001205:Ascorbic Acid; D010100:Oxygen