title: Capsule endoscopy changes patient management in routine clinical practice.
abstract: Our objective was to evaluate the diagnostic yield and effect of capsule endoscopy on patient management in routine clinical practice. Three hundred examinations were performed (176 females; mean age, 51 years), with a median follow-up of 17 months. Indications included overt bleeding (n=55), anemia (n=104), suspected Crohn's disease (n=68), celiac disease (n=35), suspected functional symptoms (n=23), polyposis (n=5), and miscellaneous (n=10). The overall diagnostic yield was 39%, but it was notably higher in overt bleeders, 66%, compared to 46% in the anemia group (P<0.025), 32% in the suspected Crohn's group (P<0.001), and 17% in the functional group (P<0.001). As a result of capsule endoscopy, management was altered in 26% of patients. This study shows that capsule endoscopy has both a high diagnostic yield and an impact on subsequent patient management. These data further support the role of capsule endoscopy in routine clinical practice.
authors.affiliation: Gastroenterology & Liver Unit, Royal Hallamshire Hospital, Glossop Road, Sheffield, S10 2JF, United Kingdom. reena_sidhu@yahoo.com
authors.forename: Reena
authors.initials: R
authors.lastname: Sidhu
authors.forename: David S
authors.initials: DS
authors.lastname: Sanders
authors.forename: Kapil
authors.initials: K
authors.lastname: Kapur
authors.forename: David P
authors.initials: DP
authors.lastname: Hurlstone
authors.forename: Mark E
authors.initials: ME
authors.lastname: McAlindon
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000740:Anemia / Q000175:diagnosis* / Q000628:therapy; D053704:Capsule Endoscopy / Q000009:adverse effects; D002446:Celiac Disease / Q000175:diagnosis* / Q000628:therapy; D002648:Child; D003424:Crohn Disease / Q000175:diagnosis* / Q000628:therapy; D005260:Female; D005500:Follow-Up Studies; D006471:Gastrointestinal Hemorrhage / Q000175:diagnosis* / Q000628:therapy; D005770:Gastrointestinal Neoplasms / Q000175:diagnosis* / Q000628:therapy; D006801:Humans; D044483:Intestinal Polyposis / Q000175:diagnosis* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011446:Prospective Studies