Statin therapy: not just used to lower cholesterol?
3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, also known as statins, are the cornerstones of treatment of hyperlipidemia. They are widely used drugs that have well-documented, advantageous effects on cholesterol and atherosclerosis. The pleiotropic activities of statins can lead to newer applications. This review describes some of the available evidence supporting the use of statins for the treatment of acute coronary syndrome, as adjuncts to percutaneous coronary intervention, and for the prevention of sepsis. It also briefly discusses the rationale behind the potential development of statin-eluting stents.
Kronmann
Lisha
L
Scripps Mercy Hospital/CardinalHealth, San Diego, California 92103, USA. knonmann.lisha@scrippshealth.org
Hatfield
Chad
C
Kronmann
Karl
K
D015906:Angioplasty, Balloon, Coronary / Q000009:adverse effects; D003327:Coronary Disease / Q000517:prevention & control*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D006937:Hypercholesterolemia / Q000517:prevention & control*; D007249:Inflammation; D018579:Patient Selection; D011182:Postoperative Care; D017410:Practice Guidelines as Topic; D018805:Sepsis / Q000517:prevention & control*; D016896:Treatment Outcome
D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors