Photonic explorers based on multifunctional nanoplatforms for biosensing and photodynamic therapy.
Nanoparticle-based photonic explorers have been developed for intracellular sensing and photodynamic therapy (PDT). The design employs nanoparticles made of various matrices as multifunctional nanoplatforms, loading active components by encapsulation or covalent attachment. The nanoplatform for biosensing has been successfully applied to intracellular measurements of important ionic and molecular species. The nanoplatform for PDT has shown high therapeutic efficacy in a rat 9L gliosarcoma model. Specifically, a multifunctional nanoplatform that encompasses magnetic resonance imaging (MRI) and PDT agents inside, as well as targeting ligands on the surface, has been developed and applied in vivo, resulting in much improved MRI contrast enhancement and PDT efficacy.
Koo
Yong-Eun Lee
YE
University of Michigan, Michigan 48109, USA. yeleekoo@umich.edu
Fan
Wenzhe
W
Hah
Hoejin
H
Xu
Hao
H
Orringer
Dan
D
Ross
Brian
B
Rehemtulla
Alnawaz
A
Philbert
Martin A
MA
Kopelman
Raoul
R
D015374:Biosensing Techniques / Q000295:instrumentation / Q000379:methods*; D016503:Drug Delivery Systems / Q000295:instrumentation / Q000379:methods*; D049329:Nanostructures / Q000627:therapeutic use*; D010778:Photochemotherapy / Q000295:instrumentation / Q000379:methods*; D017785:Photons / Q000627:therapeutic use*