DNA migration and separation on surfaces with a microscale dielectrophoretic trap array.
We studied the surface migration of DNA chains driven by a dc electric field across localized dielectrophoretic traps. By adjusting the length scale of the trap array, separation of a selected band of DNA was accomplished with a scaling exponent between mobility and number of base pairs similar to that obtained in capillary electrophoresis. We then provided a model, which predicts the trapping and extension of DNA chains at a dielectrophoretic trap responsible for the surface mobility and separation.
Petersen
Eric
E
Harvard University, Cambridge, MA 02138, USA.
Li
Bingquan
B
Fang
Xiaohua
X
Luo
Haobin
H
Samuilov
Vladimir
V
Gersappe
Dilip
D
Sokolov
Jonathan
J
Chu
Benjamin
B
Rafailovich
Miriam
M
D004279:DNA, Viral / Q000737:chemistry*; D004574:Electromagnetic Fields; D004586:Electrophoresis; D006046:Gold / Q000737:chemistry; D018613:Microscopy, Confocal; D009068:Movement; D012825:Silicon / Q000737:chemistry; D013499:Surface Properties
D004279:DNA, Viral; D006046:Gold; D012825:Silicon