title: Discriminative analysis of early Alzheimer's disease based on two intrinsically anti-correlated networks with resting-state fMRI.
abstract: In this work, we proposed a discriminative model of Alzheimer's disease (AD) on the basis of multivariate pattern classification and functional magnetic resonance imaging (fMRI). This model used the correlation/anti-correlation coefficients of two intrinsically anti-correlated networks in resting brains, which have been suggested by two recent studies, as the feature of classification. Pseudo-Fisher Linear Discriminative Analysis (pFLDA) was then performed on the feature space and a linear classifier was generated. Using leave-one-out (LOO) cross validation, our results showed a correct classification rate of 83%. We also compared the proposed model with another one based on the whole brain functional connectivity. Our proposed model outperformed the other one significantly, and this implied that the two intrinsically anti-correlated networks may be a more susceptible part of the whole brain network in the early stage of AD.
authors.affiliation: National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing 100080, China. jiangtz@nlpr.ia.ac.cn
authors.forename: Kun
authors.initials: K
authors.lastname: Wang
authors.forename: Tianzi
authors.initials: T
authors.lastname: Jiang
authors.forename: Meng
authors.initials: M
authors.lastname: Liang
authors.forename: Liang
authors.initials: L
authors.lastname: Wang
authors.forename: Lixia
authors.initials: L
authors.lastname: Tian
authors.forename: Xinqing
authors.initials: X
authors.lastname: Zhang
authors.forename: Kuncheng
authors.initials: K
authors.lastname: Li
authors.forename: Zhening
authors.initials: Z
authors.lastname: Liu
mesh_terms: D000465:Algorithms; D000544:Alzheimer Disease / Q000175:diagnosis* / Q000503:physiopathology*; D001921:Brain / Q000503:physiopathology*; D016002:Discriminant Analysis; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009415:Nerve Net / Q000503:physiopathology*; D010363:Pattern Recognition, Automated / Q000379:methods*; D015203:Reproducibility of Results; D012146:Rest; D012680:Sensitivity and Specificity; D013223:Statistics as Topic