Tightening the epidermal barrier with atypical PKCs.
The permeability barrier function of the epidermis is one of the most vital jobs performed by the skin; however, our understanding of the function and regulation of tight junctions in the epidermis remains limited. Helfrich et al. identify a key role for atypical protein kinase C (aPKC) activity, as a component of the Par3-Par6 polarity complex, in epidermal barrier function.
Denning
Mitchell F
MF
Loyola University Chicago, Cardinal Bernardin Cancer Center, Chicago, Illinois 60153, USA. mdennin@lumc.edu
D000818:Animals; D004817:Epidermis / Q000378:metabolism*; D006801:Humans; D010539:Permeability; D020033:Protein Isoforms / Q000502:physiology; D011493:Protein Kinase C / Q000502:physiology*; D019108:Tight Junctions / Q000502:physiology*
D020033:Protein Isoforms; D011493:Protein Kinase C