title: Molecular imaging with Pittsburgh Compound B confirmed at autopsy: a case report.
abstract: OBJECTIVE
  To determine the correspondence between uptake of Pittsburgh Compound B (PiB) in life and measures of beta-amyloid (Abeta) in postmortem tissue analysis. Patient A 76-year-old man with a clinical diagnosis of dementia with Lewy bodies underwent fluorodeoxyglucose (18)F and PiB positron emission tomographic brain scans. Imaging revealed marked region specific binding of PiB and abnormal fluorodeoxyglucose uptake. Intervention Autopsy was performed 3 months after the PiB scan.
  
  
  RESULTS
  Autopsy confirmed the clinical diagnosis; in addition, there was severe cerebral amyloid angiopathy and only moderate numbers of parenchymal Abeta plaques. Biochemical measures revealed a positive correlation between Abeta levels and regional PiB binding.
  
  
  CONCLUSIONS
  This report confirms that PiB detects Abeta in the living patient and demonstrates that amyloid deposited as cerebral amyloid angiopathy can be the dominant source of signal.
authors.affiliation: MassGeneral Institute for Neurodegenerative Diseases, Department of Neurology, Charlestown, MA 02129, USA. bbacskai@partners.org
authors.forename: Brian J
authors.initials: BJ
authors.lastname: Bacskai
authors.forename: Matthew P
authors.initials: MP
authors.lastname: Frosch
authors.forename: Stefanie H
authors.initials: SH
authors.lastname: Freeman
authors.forename: Scott B
authors.initials: SB
authors.lastname: Raymond
authors.forename: Jean C
authors.initials: JC
authors.lastname: Augustinack
authors.forename: Keith A
authors.initials: KA
authors.lastname: Johnson
authors.forename: Michael C
authors.initials: MC
authors.lastname: Irizarry
authors.forename: William E
authors.initials: WE
authors.lastname: Klunk
authors.forename: Chester A
authors.initials: CA
authors.lastname: Mathis
authors.forename: Steven T
authors.initials: ST
authors.lastname: Dekosky
authors.forename: Steven M
authors.initials: SM
authors.lastname: Greenberg
authors.forename: Bradley T
authors.initials: BT
authors.lastname: Hyman
authors.forename: John H
authors.initials: JH
authors.lastname: Growdon
mesh_terms: D000368:Aged; D016229:Amyloid beta-Peptides / Q000378:metabolism; D000814:Aniline Compounds; D001344:Autopsy; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology; D019788:Fluorodeoxyglucose F18; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D020961:Lewy Body Disease / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000473:pathology*; D008297:Male; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals; D013844:Thiazoles
chemical_list: C475519:2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole; D016229:Amyloid beta-Peptides; D000814:Aniline Compounds; D019275:Radiopharmaceuticals; D013844:Thiazoles; D019788:Fluorodeoxyglucose F18