A simple two-transition model for loss of infectivity of phages on exposure to organic solvent.
The effect of water-miscible organic solvents on the stability of filamentous phages displaying a random peptide library was investigated. A kinetic analysis of the time course of viral infectivity indicated that the transition between the noninfectious and infectious form was directly related to the concentration of organic solvent.
Matsubara
Teruhiko
T
Department of Biosciences and Informatics, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223-8522, Japan. matsubara@bio.keio.ac.jp
Emoto
Wakako
W
Kawashiro
Katsuhiro
K
D000818:Animals; D001435:Bacteriophages / Q000187:drug effects / Q000472:pathogenicity* / Q000502:physiology*; D003198:Computer Simulation; D006801:Humans; D008954:Models, Biological; D009930:Organic Chemicals / Q000008:administration & dosage*; D012997:Solvents / Q000008:administration & dosage*; D014775:Virus Activation / Q000187:drug effects* / Q000941:ethics*; D014777:Virus Diseases / Q000503:physiopathology
D009930:Organic Chemicals; D012997:Solvents