Effect of Mitragyna speciosa aqueous extract on ethanol withdrawal symptoms in mice.
Administration of the aqueous extract of Mitragyna speciosa at a dose of 300 mg/kg significantly inhibited ethanol withdrawal-induced behaviors that included rearing, displacement and head weaving. The results also showed that at doses of 100, 300 and 500 mg/kg M. speciosa showed antidepressant activity without effect on the spontaneous motor activity.
Kumarnsit
Ekkasit
E
Department of Physiology, Faculty of Science, Prince of Songkla University (PSU) Hat-Yai, Songkhla 90112, Thailand. ekumarnsit@yahoo.com
Keawpradub
Niwat
N
Nuankaew
Watcharin
W
D000700:Analgesics / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000009:adverse effects; D008297:Male; D051379:Mice; D032065:Mitragyna; D010146:Pain / Q000139:chemically induced / Q000517:prevention & control*; D010147:Pain Measurement / Q000187:drug effects; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018515:Plant Leaves; D013375:Substance Withdrawal Syndrome / Q000473:pathology
D000700:Analgesics; D010936:Plant Extracts; D000431:Ethanol