Comparative biology of human and canine osteosarcoma.
Dogs with osteosarcoma provide an important model for the same disease in humans. In this report, the comparative nature of human and canine osteosarcoma including incidence and risk factors, clinical presentation and diagnosis, genetic abnormalities, biologic behaviour and prognostic factors, as well as treatment options are reviewed.
Mueller
F
F
Section of Diagnostic Imaging and Radiation Oncology, Vetsuisse Faculty, University of Zürich, Winterthurerstrasse 260, 8057 Zurich, Switzerland. fmueller@vetclinics.unizh.ch
Fuchs
B
B
Kaser-Hotz
B
B
D000818:Animals; D001859:Bone Neoplasms / Q000235:genetics / Q000473:pathology* / Q000628:therapy / Q000662:veterinary*; D004195:Disease Models, Animal; D004283:Dog Diseases / Q000235:genetics / Q000473:pathology* / Q000628:therapy; D004285:Dogs; D006801:Humans; D012516:Osteosarcoma / Q000235:genetics / Q000473:pathology* / Q000628:therapy / Q000662:veterinary*