Biological evaluation of fluorinated p-boronophenylalanine derivatives as a boron carrier.
Boron neutron capture therapy (BNCT) and magnetic resonance imaging (MRI) are quite attractive techniques for treatment and diagnosis of cancer, respectively. In order to develop practical materials utilizing both for BNCT and MRI, fluorinated p-boronophenylalanines and their alcohol derivatives had already been designed and synthesized. In the present paper the cytotoxicity, the incorporated amount into cancer cells, and the tumor cell killing effects of these compounds were elucidated to evaluate their usefulness as a boron carrier.
Hattori
Yoshihide
Y
Faculty of Science and Technology, Kinki University, Higashi-osaka, Osaka 577-8502, Japan.
Kurihara
Kei
K
Kondoh
Hirofumi
H
Asano
Tomoyuki
T
Kirihata
Mitsunori
M
Yamaguchi
Yoshihiro
Y
Wakamiya
Tateaki
T
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D001895:Boron / Q000378:metabolism*; D001896:Boron Compounds / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D004354:Drug Screening Assays, Antitumor; D005910:Glioma / Q000473:pathology; D006845:Hydrocarbons, Fluorinated / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology*; D017136:Ion Transport; D008954:Models, Biological; D010649:Phenylalanine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D051381:Rats; D012995:Solubility; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D001896:Boron Compounds; D006845:Hydrocarbons, Fluorinated; D010649:Phenylalanine; D001895:Boron; C033685:4-boronophenylalanine