title: Ten years of viral and non-bacterial serology in adults with cystic fibrosis.
abstract: Viral infections are associated with pulmonary exacerbations in children with cystic fibrosis (CF), but few studies have addressed the frequency in adults. This paper investigates the frequency and impact of viral infections in adults with CF receiving intravenous antibiotics. Pre- and post-treatment spirometry, inflammatory markers and antibody titres against influenza A, influenza B, adenovirus, respiratory syncytial virus, Mycoplasma pneumoniae, Chlamydia psittaci, and Coxiella burnetti were analysed over a 10-year period. Non-bacterial infections were identified in 5.1% of 3156 courses of treatment. The annual incidence of admissions per patient associated with viral infection was 4.9%. The presence of viral infection in association with a pulmonary exacerbation did not adversely affect lung function or inflammatory markers in the short term. Adults with CF have a lower incidence of respiratory viral infections associated with pulmonary exacerbations requiring intravenous antibiotics compared to children and infants with CF.
authors.affiliation: Regional Cystic Fibrosis Unit, Seacroft Hospital, Leeds, UK. i.j.clifton@btinternet.com
authors.forename: I J
authors.initials: IJ
authors.lastname: Clifton
authors.forename: J A
authors.initials: JA
authors.lastname: Kastelik
authors.forename: D G
authors.initials: DG
authors.lastname: Peckham
authors.forename: A
authors.initials: A
authors.lastname: Hale
authors.forename: M
authors.initials: M
authors.lastname: Denton
authors.forename: C
authors.initials: C
authors.lastname: Etherington
authors.forename: S P
authors.initials: SP
authors.lastname: Conway
mesh_terms: D000256:Adenoviridae / Q000276:immunology; D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D000914:Antibodies, Viral / Q000097:blood; D002691:Chlamydophila psittaci / Q000302:isolation & purification; D003381:Coxiella / Q000302:isolation & purification; D003550:Cystic Fibrosis / Q000150:complications*; D004739:England / Q000453:epidemiology; D005260:Female; D006801:Humans; D009980:Influenza A virus / Q000276:immunology; D009981:Influenza B virus / Q000276:immunology; D008297:Male; D008499:Medical Records; D008875:Middle Aged; D009177:Mycoplasma pneumoniae / Q000276:immunology; D015995:Prevalence; D012136:Respiratory Syncytial Viruses / Q000276:immunology; D012141:Respiratory Tract Infections / Q000097:blood / Q000150:complications / Q000188:drug therapy / Q000453:epidemiology* / Q000382:microbiology / Q000821:virology*; D012189:Retrospective Studies; D013147:Spirometry
chemical_list: D000900:Anti-Bacterial Agents; D000914:Antibodies, Viral