title: Management of intracranial invasive olfactory neuroblastoma.
abstract: BACKGROUND
  Olfactory neuroblastoma (ONB) is a rare tumor that often arise from the nasal cavity. The aim of this study was to investigate the clinical characteristics and treatments of intracranial invasive ONB.
  
  
  METHODS
  Between July 2001 and August 2005, 5 patients with intracranial invasive ONB were treated in our department. Their clinical features, radiological and pathological characteristics, and surgical treatments were analyzed. Among the 5 patients, 1 received transnasal biopsy, and 4 were operated through the transfrontal or extended bifrontal approaches to reconstruct the skull base. After the operation, all the patients received radiotherapy, and one received chemotherapy. They were followed up for 6 to 45 months.
  
  
  RESULTS
  The ONB was resected totally in the 4 patients. In all the patients, nasal obstruction was alleviated without cerebrospinal fluid leakage. The visual acuity was improved in 3 patients, who had a decreased visual acuity before the operation. Two patients had metastasis into the lumbosacral spinal canal 6 and 8 months after the operation, one of them received a second operation and the other died.
  
  
  CONCLUSIONS
  ONB has no specific symptoms. Intracranial ONB should be resected as far as possible, and treated by radiotherapy after the operation.
authors.affiliation: Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China. zlwtt@yahoo.com.cn
authors.forename: Li-wei
authors.initials: LW
authors.lastname: Zhang
authors.forename: Ming-shan
authors.initials: MS
authors.lastname: Zhang
authors.forename: Ji
authors.initials: J
authors.lastname: Qi
authors.forename: Jun-ting
authors.initials: JT
authors.lastname: Zhang
authors.forename: Gui-lin
authors.initials: GL
authors.lastname: Li
authors.forename: Lin
authors.initials: L
authors.lastname: Luo
authors.forename: Zhong-cheng
authors.initials: ZC
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D000328:Adult; D001932:Brain Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000601:surgery*; D018304:Esthesioneuroblastoma, Olfactory / Q000175:diagnosis / Q000473:pathology / Q000601:surgery*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D014057:Tomography, X-Ray Computed