title: [Ultraviolet irradiation-mediated malignant melanoma induction with RET tyrosine kinase activation].
abstract: We previously established a RET-transgenic mouse line (304/B6), in which skin melanosis, benign melanocytic tumors and malignant melanoma spontaneously develop. We found that the activities of RET tyrosine kinase, Erk and c-Jun are definitely upregulated in malignant melanoma in the RET-transgenic mice of line 304/B6. We also established another RET-transgenic mouse line (192), in which skin melanosis and benign melanocytic tumors, but not malignant melanoma, spontaneously develop. Ultraviolet irradiation induced malignant melanoma from benign tumors in the RET-transgenic mice of line 192, and promoted RET tyrosine kinase, Erk and c-Jun activities. These results suggest that the ultraviolet irradiation-mediated enhancement of RET and the activity of its downstream molecules play important roles in malignant melanoma development.
authors.affiliation: Unit of Environmental Health Sciences, Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University (Building No. 50, 11F), 1200 Matsumotocho, Kasugaishi, Aichi 487-8501, Japan. katomasa@isc.chubu.ac.jp
authors.forename: Masashi
authors.initials: M
authors.lastname: Kato
authors.forename: Kozue
authors.initials: K
authors.lastname: Takeda
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Kawamoto
authors.forename: Khaled
authors.initials: K
authors.lastname: Hossain
authors.forename: Nobutaka
authors.initials: N
authors.lastname: Ohgami
authors.forename: Takeshi
authors.initials: T
authors.lastname: Yanagishita
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Ohshima
authors.forename: Yoko
authors.initials: Y
authors.lastname: Kato
authors.forename: Kyoko
authors.initials: K
authors.lastname: Ohgami
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Yamamori
authors.forename: Keisuke
authors.initials: K
authors.lastname: Tateyama
authors.forename: Osamu
authors.initials: O
authors.lastname: Yamanoshita
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D048049:Extracellular Signal-Regulated MAP Kinases / Q000378:metabolism; D020782:Matrix Metalloproteinases / Q000378:metabolism; D008545:Melanoma / Q000209:etiology*; D051379:Mice; D016755:Proto-Oncogene Proteins c-jun / Q000378:metabolism; D051096:Proto-Oncogene Proteins c-ret / Q000378:metabolism*; D014466:Ultraviolet Rays / Q000009:adverse effects*
chemical_list: D016755:Proto-Oncogene Proteins c-jun; D051096:Proto-Oncogene Proteins c-ret; D048049:Extracellular Signal-Regulated MAP Kinases; D020782:Matrix Metalloproteinases