Association between serotonin transporter availability and hostility scores in healthy volunteers - a single photon emission computed tomography study with [(123)I] ADAM.
The present study examined the relationship between serotonin transporter (SERT) availability and hostility scores in healthy volunteers. SERT availability was measured by using SPECT with [(123)I] ADAM in 10 healthy participants. Hostility was measured with the Cook-Medley Hostility Scale. Hostile attribution, but not the other subscales of hostility, was negatively correlated with SERT availability. Central serotoninergic activities may play a role in hostility.
Yang
Yen Kuang
YK
Department of Psychiatry, College of Medicine, National Cheng Kung University, 138 Sheng Li Road, Tainan 70403, Taiwan. ykyang@mail.ncku.edu.tw
Yao
Wei Jen
WJ
Yeh
Tzung Lieh
TL
Lee
I Hui
IH
Chen
Kao Ching
KC
Lu
Ru Band
RB
D000328:Adult; D001921:Brain / Q000378:metabolism*; D002928:Cinanserin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D005260:Female; D006791:Hostility; D006801:Humans; D007275:Injections, Intravenous; D007457:Iodine Radioisotopes / Q000008:administration & dosage / Q000493:pharmacokinetics; D008297:Male; D050486:Serotonin Plasma Membrane Transport Proteins / Q000378:metabolism*; D015899:Tomography, Emission-Computed, Single-Photon
C413491:2-((2-((dimethylamino)methyl)phenyl)thio)-5-iodophenylamine; D007457:Iodine Radioisotopes; D050486:Serotonin Plasma Membrane Transport Proteins; D002928:Cinanserin