New Cleavage Methods for Cardiac Glycosides having a Doubly Linked Sugar1.
New cleavage methods for cardiac glycosides having a doubly linked sugar are described. Treatment with pyridine, alumina, or phenylhydrazine gave the desired genin in reasonable yield. The reaction products were separated and determined by high-performance liquid chromatography. The mechanism of the cleavage reaction has also been discussed.
Shimada
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On leave from College of Pharmacy, Chung-Buk National University, Cheongju 310, Korea.
Kyuno
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Nambara
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Uchida
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