Heart development: the battle between mesoderm and endoderm.
Recent years have seen a surge of scientific research examining the interdependence of one germ layer in the development of the other, both in vivo and in vitro. For example, the endoderm is believed to play a crucial role in the formation of mesoderm and subsequent maturation of cells belonging to the mesodermal lineage. Our understanding of this complex relationship is continuously growing with reinterpretation of earlier concepts and apprehension of newer hypotheses into the biology of embryonic development. Here we discuss some of the events governing the cooperative control of endoderm over mesoderm, and propose a perspective based on the existing literature and our own experience.
Pal
Rajarshi
R
Embryonic Stem Cell Group, Reliance Life Sciences Pvt. Ltd. Dhirubhai Ambani Life Sciences Center, Navi Mumbai, India.
Khanna
Aparna
A
D000818:Animals; D047108:Embryonic Development; D053595:Embryonic Stem Cells / Q000166:cytology; D004707:Endoderm / Q000378:metabolism*; D006321:Heart / Q000196:embryology*; D008648:Mesoderm / Q000378:metabolism*; D032383:Myocytes, Cardiac / Q000166:cytology; D038081:Organogenesis