Regional node dissection for melanoma: techniques and indication.
Because virtually all microscopic nodal disease left untreated in melanoma patients will progress to clinically apparent macroscopic nodal disease, there is worse prognosis with macroscopic nodal disease, and ineffective systemic treatment currently exists, one must be cautious in favoring an observation approach to the regional basin in patients with a positive sentinel lymph node (SLN) in the hopes of avoiding the potential morbidity of a therapeutic node dissection. In the few patients with untreated microscopic nodal disease, the prognosis will be significantly worsened. Until further data are available, melanoma patients with a positive SLN by H&E analysis should proceed to a complete lymph node dissection.
Jakub
James W
JW
Cutaneous Oncology Program, Lakeland Regional Cancer Center, 3525 Lakeland Hills Blvd., P.O. Box 91057, Lakeland, FL 33805-1057, USA.
Reintgen
Douglas S
DS
Shivers
Steven
S
Pendas
Solange
S
D001365:Axilla / Q000473:pathology; D006801:Humans; D008197:Lymph Node Excision; D008207:Lymphatic Metastasis; D008545:Melanoma / Q000401:mortality / Q000473:pathology* / Q000601:surgery*; D037981:Neck Dissection; D011379:Prognosis; D016032:Randomized Controlled Trials as Topic; D021701:Sentinel Lymph Node Biopsy; D016019:Survival Analysis