title: Metformin-associated lactic acidosis in a burn patient.
abstract: Hyperglycemia commonly is observed as part of the hypermetabolic response to severe burn injury. In routine burn care, physicians use interventions to address and reduce the complications of this stress-induced hyperglycemia. Metformin (1,1-dimethylbiguanide), an orally administered hyperglycemic medication, has been used previously to modulate the stress-induced hyperglycemic response in nondiabetic burn patients. The use of this medication in nonburn diabetic patients has been associated with the development of lactic acidosis. We present an acute burn patient who developed lactic acidosis while receiving metformin for management of his diabetes.
authors.affiliation: Department of Surgery, North Carolina Jaycee Burn Center, University of North Carolina Hospitals, Chapel Hill, North Carolina 27514, USA.
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Riesenman
authors.forename: Susan S
authors.initials: SS
authors.lastname: Braithwaite
authors.forename: Bruce A
authors.initials: BA
authors.lastname: Cairns
mesh_terms: D000140:Acidosis, Lactic / Q000139:chemically induced*; D002056:Burns / Q000150:complications*; D003404:Creatinine / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy*; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D019344:Lactic Acid / Q000097:blood; D008297:Male; D008687:Metformin / Q000008:administration & dosage / Q000009:adverse effects*; D008875:Middle Aged
chemical_list: D007004:Hypoglycemic Agents; D019344:Lactic Acid; D008687:Metformin; D003404:Creatinine