[Profiles of multiple causes of death related to HIV/AIDS in the cities of São Paulo and Santos, Brazil, 2001].
Following the introduction of highly active antiretroviral therapy (HAART), the HIV-related morbidity-mortality profile has changed. Opportunistic infections are not as prevalent as before, and "pre-AIDS" diseases have become more common, related mostly to the side effects of HAART. This study focused on HIV/AIDS-related mortality, based on multiple causes of death among individuals who died of HIV-related causes in the cities of São Paulo and Santos, Brazil, in 2001. Grade of Membership (GoM) analysis was used. Three mortality profiles were detected: (1) causes of death normally observed before the introduction of HAART, marked by opportunistic infections; (2) causes of death with mixed characteristics, both pre- and post-HAART; and (3) a residual profile, which did not contemplate HIV disease, but incorporated causes of death associated with the pre and post-HAART periods. It is hoped that the current study will contribute to the understanding of the HIV/AIDS morbidity-mortality scenario and help improve the treatment and care provided by public health services.
Pereira
Claudia Cristina de Aguiar
CC
Department of Population Health Sciences, University of Wisconsin Medical School, Madison, WI, USA.
Machado
Carla Jorge
CJ
Rodrigues
Roberto do Nascimento
Rdo N
D017088:AIDS-Related Opportunistic Infections / Q000401:mortality*; D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy / Q000401:mortality*; D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects*; D001938:Brazil / Q000453:epidemiology; D002423:Cause of Death; D017143:Fuzzy Logic; D006801:Humans; D007256:Information Systems / Q000706:statistics & numerical data; D009017:Morbidity / Q000639:trends; D015999:Multivariate Analysis