Ovarian cancer activity of cyclic amine and thiaether metal complexes.
A thiaether metal complex 1-aza-4,7-dithiacyclononane-RhCl3, 2, and cyclic amine metal complexes tacn-CuBr2, 3, and Me3tacn-RuCl3, 4, have been evaluated for anticancer activity against the ovarian cancer cell line NuTu-19 and for cell toxicity against the noncancerous ovarian tissue cell line OVepi. Specifically, metal complex 2 is active when compared to cisplatin at micromolar concentrations using the MTT and cell invasion assay. The in vitro results reported warrant further evaluation of metal complex 2 in living systems.
Medvetz
Doug A
DA
The University of Akron, 190 East Buchtel Commons, Akron, Ohio 44325, USA.
Stakleff
Kimberly D
KD
Schreiber
Tara
T
Custer
Paul D
PD
Hindi
Khadijah
K
Panzner
Matthew J
MJ
Blanco
Denise D
DD
Taschner
Michael J
MJ
Tessier
Claire A
CA
Youngs
Wiley J
WJ
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002460:Cell Line; D045744:Cell Line, Tumor; D003300:Copper; D004354:Drug Screening Assays, Antitumor; D005260:Female; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D010051:Ovarian Neoplasms; D051381:Rats; D011916:Rats, Inbred F344; D012238:Rhodium; D012428:Ruthenium; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D009942:Organometallic Compounds; C519522:trichloro(1-aza-4,7-dithiacyclononane)rhodium(III); D003300:Copper; D012428:Ruthenium; D012238:Rhodium