Triggered activity and atrial fibrillation.
In 1999, Haissaguerre et al published a landmark article showing that atrial fibrillation can be initiated by electrical activity in the pulmonary veins. Not only does it appear that electrical activity in the veins initiates fibrillation, but it also may be responsible for perpetuating fibrillation. Subsequently, similar evidence has suggested that other thoracic veins (vena cavae, coronary sinus, ligament of Marshall) initiate and perpetuate atrial fibrillation. How does electrical impulse initiation occur in the veins? The results of numerous in vivo and in vitro studies on this subject have not conclusively defined a mechanism. Impulse initiation by automaticity and triggered activity as well as impulse initiation resulting from reentry have been suggested. In this article, we focus only on those data suggesting the possibility that triggered activity initiates and/or perpetuates atrial fibrillation.
Wit
Andrew L
AL
Department of Pharmacology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA.
Boyden
Penelope A
PA
D000200:Action Potentials; D000818:Animals; D001281:Atrial Fibrillation / Q000503:physiopathology*; D006325:Heart Atria / Q000503:physiopathology; D006329:Heart Conduction System / Q000503:physiopathology*; D006801:Humans; D010210:Papillary Muscles / Q000503:physiopathology; D011667:Pulmonary Veins / Q000503:physiopathology; D012850:Sinus of Valsalva / Q000503:physiopathology; D013997:Time Factors; D014684:Venae Cavae / Q000503:physiopathology