Correlation of clinical and histopathological with endoscopic findings of celiac disease in the Turkish population.
Endoscopic findings have been described for the diagnosis of celiac disease but the relationship among the clinical presentation, endoscopic markers, and the degree of histopathological findings is not clear. Thirty patients who were thought to have celiac disease were included in this study. Biopsies taken from the duodenum were examined histopathologically. The relationship among the endoscopic, clinical, and histopathological findings were investigated. Partial villous atrophy was seen in 14 patients (46.6%), and subtotal and total villous atrophy were seen in 6 (20%) patients each. Eighty six percent of patients with a mosaic appearance, 76% of patients with the finding of loss of folds, and 90% of patients with scalloping on endoscopy had either partial villous atrophy, subtotal villous atrophy, or total villous atrophy on biopsy. We conclude that endoscopic findings in celiac disease can reveal valuable information both for diagnosis and for demonstration of the severity of the disease state.
Savas
Nurten
N
Department of Gastroenterology, Baskent University Faculty of Medicine, Fevzi Cakmak Cad. 10, Sok No. 45, Bahcelievler, Ankara, 06490, Turkey. nakyurek2000@yahoo.com
Akbulut
Sabiye
S
Saritas
Ulku
U
Koseoglu
Tankut
T
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001284:Atrophy; D002446:Celiac Disease / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology; D004384:Duodenoscopy; D004386:Duodenum / Q000473:pathology* / Q000503:physiopathology; D005260:Female; D006801:Humans; D007413:Intestinal Mucosa / Q000473:pathology*; D008297:Male; D008871:Microvilli / Q000473:pathology; D008875:Middle Aged; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D014421:Turkey