title: 64-Slice CT coronary angiography in patients with non-ST elevation acute coronary syndrome.
abstract: BACKGROUND
  A high diagnostic accuracy of 64-slice CT coronary angiography (CTCA) has been reported in selected patients with stable angina pectoris, but only scant information is available in patients with non-ST elevation acute coronary syndrome (ACS).
  
  
  OBJECTIVE
  To study the diagnostic performance of 64-slice CTCA in patients with non-ST elevation ACS.
  
  
  METHODS
  64-slice CTCA was performed in 104 patients (mean (SD) age 59 (9) years) with non-ST elevation ACS. Two independent, blinded observers assessed all coronary arteries for stenosis, using conventional quantitative angiography as a reference. Coronary lesions with >or=50% luminal narrowing were classified as significant.
  
  
  RESULTS
  Conventional coronary angiography demonstrated the absence of significant disease in 15% (16/104) of patients, and the presence of single-vessel disease in 40% (42/104) and multivessel disease in 44% (46/104) of patients. Sensitivity for detecting significant coronary stenoses on a patient-by-patient analysis was 100% (88/88; 95% CI 95 to 100), specificity 75% (12/16; 95% CI 47 to 92), and positive and negative predictive values were 96% (88/92; 95% CI 89 to 99) and 100% (12/12; 95% CI 70 to 100), respectively.
  
  
  CONCLUSIONS
  64-slice CTCA has a high sensitivity to detect significant coronary stenoses, and is reliable to exclude the presence of significant coronary artery disease in patients who present with a non-ST elevation ACS.
authors.affiliation: Department of Cardiology, Thoraxcenter, and Radiology, Rotterdam, The Netherlands.
authors.forename: Willem B
authors.initials: WB
authors.lastname: Meijboom
authors.forename: Nico R
authors.initials: NR
authors.lastname: Mollet
authors.forename: Carlos A
authors.initials: CA
authors.lastname: Van Mieghem
authors.forename: Annick C
authors.initials: AC
authors.lastname: Weustink
authors.forename: Francesca
authors.initials: F
authors.lastname: Pugliese
authors.forename: Niels
authors.initials: N
authors.lastname: van Pelt
authors.forename: Filippo
authors.initials: F
authors.lastname: Cademartiri
authors.forename: Eleni
authors.initials: E
authors.lastname: Vourvouri
authors.forename: Peter
authors.initials: P
authors.lastname: de Jaegere
authors.forename: Gabriel P
authors.initials: GP
authors.lastname: Krestin
authors.forename: Pim J
authors.initials: PJ
authors.lastname: de Feyter
mesh_terms: D054058:Acute Coronary Syndrome / Q000000981:diagnostic imaging*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017023:Coronary Angiography / Q000379:methods*; D023921:Coronary Stenosis / Q000000981:diagnostic imaging; D004562:Electrocardiography; D004812:Epidemiologic Methods; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008297:Male; D008875:Middle Aged; D014057:Tomography, X-Ray Computed