title: Comparison of hydroxyzine and doxepin in treatment of pruritus due to sulfur mustard.
abstract: OBJECTIVE
  To compare the safety and efficacy of doxepin and hydroxyzine in the treatment of chronic pruritus due to exposure to sulfur mustard.
  
  
  METHODS
  In a randomized, double-blind safety and efficacy study, 50 patients with chronic pruritus were given either doxepin 10 mg/d or hydroxyzine 25 mg/d for 4 weeks. Pruritic score was calculated for each patient before treatment and 1 month after.
  
  
  RESULTS
  After treatment, the mean pruritic scores +/- SD of the hydroxyzine and doxepin groups were 16.7+/-2.3 and 17.8+/-2.5, respectively. The severity of pruritus was decreased in 80% of patients in the hydroxyzine group and 75% in the doxepin group (P=.786). Eighteen patients in the hydroxyzine group and 14 patients in the doxepin group reported sedation.
  
  
  CONCLUSIONS
  Both hydroxyzine and doxepin are effective and have equivalent results in controlling the symptoms of patients with chronic pruritus due to exposure to sulfur mustard.
authors.affiliation: Research Center of Chemical Injuries, Baqiyatallah Medical Sciences University, Tehran, Iran.
authors.forename: Majid
authors.initials: M
authors.lastname: Shohrati
authors.forename: Ali
authors.initials: A
authors.lastname: Tajik
authors.forename: Ali Amini
authors.initials: AA
authors.lastname: Harandi
authors.forename: Seyed Masoud
authors.initials: SM
authors.lastname: Davoodi
authors.forename: Mahmood
authors.initials: M
authors.lastname: Akmasi
mesh_terms: D000328:Adult; D000982:Antipruritics / Q000627:therapeutic use*; D002619:Chemical Warfare Agents / Q000506:poisoning; D004311:Double-Blind Method; D004316:Doxepin / Q000627:therapeutic use*; D006801:Humans; D006919:Hydroxyzine / Q000627:therapeutic use*; D009151:Mustard Gas / Q000506:poisoning*; D011537:Pruritus / Q000139:chemically induced* / Q000188:drug therapy*
chemical_list: D000982:Antipruritics; D002619:Chemical Warfare Agents; D004316:Doxepin; D006919:Hydroxyzine; D009151:Mustard Gas