Kinetics of decomposition of rabeprazole sodium in aqueous solutions determined by high performance liquid chromatography.
The kinetics of decomposition of rabeprazole sodium in aqueous solutions at elevated temperatures has been investigated by high performance liquid chromatography. The reaction is found to follow first-order kinetics and the rate constant for the degradation at 25 degrees C is estimated by extrapolation. The breakdown of rabeprazole sodium is shown to be water and hydrogen ion catalysed and the effects of ionic strength and buffer concentrations to such rate studies are discussed.
Mbah
C J
CJ
DMI Inc., 86 N. Main Street, Wharton, NJ 07885, USA.
D053799:2-Pyridinylmethylsulfinylbenzimidazoles / Q000737:chemistry*; D002021:Buffers; D002138:Calibration; D002851:Chromatography, High Pressure Liquid; D007700:Kinetics; D064750:Rabeprazole; D012015:Reference Standards; D012996:Solutions
D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D002021:Buffers; D012996:Solutions; D064750:Rabeprazole