title: Celiac disease associated antibodies in persons with latent autoimmune diabetes of adult and type 2 diabetes.
abstract: BACKGROUND
  Celiac Disease (CD) is present in 1-16.4% of patients with type 1 diabetes mellitus. The most important serological markers of CD are anti-endomysial (EMA), anti-tissue transglutaminase (tTGA) and antigliadin antibodies (AGA).
  
  
  OBJECTIVE
  The objective of this work is to determine the frequency of tTGA and/or AGA in latent autoimmune diabetes of adult (LADA) and subjects with type 2 diabetes (T2DM), as well as to evaluate their relation with several clinical and biochemical characteristics.
  
  
  METHODS
  Forty three subjects with LADA and 99 with T2DM were studied. The presence of AGA, tTGA was determined in the sera of these patients. The variables: sex, age, duration of diabetes, treatment, body mass index (BMI) and fasting blood glucose concentration were also recorded.
  
  
  RESULTS
  No differences were found in the frequency of celiac disease associated antibodies between LADA and T2DM subjects. The presence of celiac disease related antibodies was more frequent in patients with a normal or low BMI.
  
  
  CONCLUSIONS
  Celiac disease does not seem to be related with pancreatic autoimmunity in type 2 diabetes. Celiac disease causes a decrease of body mass index in type 2 diabetes while pancreatic islet autoimmunity in this entity masks this effect.
authors.affiliation: Department of Diabetes Mellitus Immunity, National Institute of Endocrinology, Zapata and D, Vedado, Havana 10 400, Cuba.
authors.forename: J C
authors.initials: JC
authors.lastname: Sánchez
authors.forename: Julio Cesar Sánchez
authors.initials: JC
authors.lastname: Cruz
authors.forename: E
authors.initials: E
authors.lastname: Cabrera-Rode
authors.forename: Eduardo Cabrera
authors.initials: EC
authors.lastname: Rode
authors.forename: L
authors.initials: L
authors.lastname: Sorell
authors.forename: Luis Sorell
authors.initials: LS
authors.lastname: Gómez
authors.forename: J A
authors.initials: JA
authors.lastname: Galvan
authors.forename: José A Galvan
authors.initials: JA
authors.lastname: Cabrera
authors.forename: A
authors.initials: A
authors.lastname: Hernandez
authors.forename: Ania Hernandez
authors.initials: AH
authors.lastname: Ortega
authors.forename: G
authors.initials: G
authors.lastname: Molina
authors.forename: Gisela Molina
authors.initials: GM
authors.lastname: Mato
authors.forename: P A
authors.initials: PA
authors.lastname: Perich
authors.forename: Pedro A Perich
authors.initials: PA
authors.lastname: Amador
authors.forename: M E
authors.initials: ME
authors.lastname: Licea
authors.forename: Manuel E Licea
authors.initials: ME
authors.lastname: Puig
authors.forename: E
authors.initials: E
authors.lastname: Domínguez
authors.forename: Emma Domínguez
authors.initials: ED
authors.lastname: Alonso
authors.forename: O
authors.initials: O
authors.lastname: Díaz-Horta
authors.forename: Oscar
authors.initials: O
authors.lastname: Díaz-Horta
mesh_terms: D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000276:immunology*; D015992:Body Mass Index; D002446:Celiac Disease / Q000276:immunology*; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology*; D003924:Diabetes Mellitus, Type 2 / Q000276:immunology*; D005260:Female; D005903:Gliadin / Q000276:immunology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011503:Transglutaminases / Q000276:immunology
chemical_list: D001323:Autoantibodies; D005903:Gliadin; D011503:Transglutaminases