Discordance of clinical symptoms and electrophysiologic findings in taxane plus platinum-induced neuropathy.
Paclitaxel combined with carboplatin is currently accepted as the first-line treatment for ovarian carcinoma, frequently associated with neuropathy. Due to its frequent association with neuropathy, combination of docetaxel and carboplatin has been suggested as an alternative. A 47-year-old woman developed paresthesia after the first cycle of paclitaxel/carboplatin for ovarian cancer. Her nerve conduction study (NCS) showed only sural neuropathy after completion of six cycles, which returned to normal in 6 months. She had fewer neuropathy symptoms when treatment was changed to docetaxel/carboplatin for recurrent cancer. NCS revealed generalized sensory neuropathy following docetaxel/carboplatin treatment, which normalized after 12 months. Our observation indicated that there is a disparity between clinical symptoms and electrophysiologic examination in taxane-induced neuropathy. Although docetaxel was tolerated well by the patient, evidence of generalized sensory neuropathy was present in NCS.
Pan
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Y
Department of Neurology, Saint Louis University Hospital, St. Louis, MO 63110, USA. pany@slu.edu
Kao
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MS
D000200:Action Potentials / Q000187:drug effects; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D001952:Bridged-Ring Compounds / Q000008:administration & dosage* / Q000009:adverse effects; D018269:Carcinoma, Endometrioid / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009422:Nervous System Diseases / Q000139:chemically induced* / Q000175:diagnosis*; D009475:Neurons, Afferent / Q000187:drug effects / Q000502:physiology; D010051:Ovarian Neoplasms / Q000188:drug therapy*; D010984:Platinum / Q000008:administration & dosage* / Q000009:adverse effects; D043823:Taxoids / Q000008:administration & dosage* / Q000009:adverse effects
D001952:Bridged-Ring Compounds; D043823:Taxoids; C080625:taxane; D010984:Platinum