title: Serum paraoxonase-1 in chronic alcoholics: relationship with liver disease.
abstract: OBJECTIVE
  To investigate the relationship between serum paraoxonase-1 and liver damage in chronic alcoholic patients. To assess the diagnostic accuracy of paraoxonase-1 plus standard biochemical tests in the assessment of liver damage in alcoholics.
  
  
  METHODS
  We studied 328 chronic alcoholics and 368 healthy individuals.
  
  
  RESULTS
  Paraoxonase-1 activity was decreased and the concentration was increased in alcoholics (P<0.001). The enzyme activity was correlated with albumin (r=0.45; P<0.001) and prothrombin time (r=0.49; P<0.001). Addition of paraoxonase-1 activity measurement to a battery of biochemical tests increased the sensitivity in differentiating between patients and controls up to 96.6% but did not improve the sensitivity in differentiating between subgroups of alcoholics.
  
  
  CONCLUSIONS
  Paraoxonase-1 was related to the severity of alcoholic liver disease. Its measurement was useful in discriminating between patients and healthy subjects, but did not add any valuable information in subgroups of alcoholics.
authors.affiliation: Centre de Recerca Biomèdica, Hospital Universitari de Sant Joan, Institut de Recerca en Ciències de la Salut, Reus, Spain.
authors.forename: Judit
authors.initials: J
authors.lastname: Marsillach
authors.forename: Natàlia
authors.initials: N
authors.lastname: Ferré
authors.forename: Maria C
authors.initials: MC
authors.lastname: Vila
authors.forename: Anna
authors.initials: A
authors.lastname: Lligoña
authors.forename: Bharti
authors.initials: B
authors.lastname: Mackness
authors.forename: Michael
authors.initials: M
authors.lastname: Mackness
authors.forename: Ramon
authors.initials: R
authors.lastname: Deulofeu
authors.forename: Ricard
authors.initials: R
authors.lastname: Solá
authors.forename: Albert
authors.initials: A
authors.lastname: Parés
authors.forename: Juan
authors.initials: J
authors.lastname: Pedro-Botet
authors.forename: Jorge
authors.initials: J
authors.lastname: Joven
authors.forename: Joan
authors.initials: J
authors.lastname: Caballeria
authors.forename: Jordi
authors.initials: J
authors.lastname: Camps
mesh_terms: D000328:Adult; D000368:Aged; D000437:Alcoholism / Q000150:complications* / Q000201:enzymology*; D043303:Aryldialkylphosphatase / Q000097:blood*; D005260:Female; D006801:Humans; D008108:Liver Diseases, Alcoholic / Q000201:enzymology*; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D011517:Prothrombin Time; D012709:Serum Albumin / Q000032:analysis
chemical_list: D012709:Serum Albumin; D043303:Aryldialkylphosphatase