title: Characterization of the NikA histidine kinase implicated in the phosphorelay signal transduction of Aspergillus nidulans, with special reference to fungicide responses.
abstract: We recently compiled a complete list of phosphorelay signal transduction components in the model filamentous fungus Aspergillus nidulans. In this study, we characterized a histidine protein kinase (designated NikA) that is found in many fungi, with special reference to responses to potent fungicides (iprodione and fludioxonil). We provided evidence that not only NikA, but also two downstream response regulators (SskA and SrrA) are crucially implicated in the mode of action of these fungicides, and also that the further downstream HogA-MAPK cascade is exaggerated abnormally (or ectopically) in hyphae by the fungicides in a manner dependent on the NikA-SskA phosphorelay.
authors.affiliation: Laboratory of Molecular Microbiology, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya, Japan. t2706693@mbox.nagoya-u.ac.jp
authors.forename: Daisuke
authors.initials: D
authors.lastname: Hagiwara
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Matsubayashi
authors.forename: Junichiro
authors.initials: J
authors.lastname: Marui
authors.forename: Kentaro
authors.initials: K
authors.lastname: Furukawa
authors.forename: Takafumi
authors.initials: T
authors.lastname: Yamashino
authors.forename: Kyoko
authors.initials: K
authors.lastname: Kanamaru
authors.forename: Masashi
authors.initials: M
authors.lastname: Kato
authors.forename: Keietsu
authors.initials: K
authors.lastname: Abe
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Kobayashi
authors.forename: Takeshi
authors.initials: T
authors.lastname: Mizuno
mesh_terms: D000620:Aminoimidazole Carboxamide / Q000031:analogs & derivatives* / Q000494:pharmacology; D001233:Aspergillus nidulans / Q000502:physiology*; D004149:Dioxoles / Q000494:pharmacology*; D005656:Fungal Proteins / Q000235:genetics / Q000378:metabolism*; D005659:Fungicides, Industrial / Q000494:pharmacology*; D000071677:Histidine Kinase; D006827:Hydantoins / Q000494:pharmacology*; D009154:Mutation; D010766:Phosphorylation; D011494:Protein Kinases / Q000235:genetics / Q000378:metabolism*; D011758:Pyrroles / Q000494:pharmacology*; D015398:Signal Transduction / Q000502:physiology
chemical_list: D004149:Dioxoles; D005656:Fungal Proteins; D005659:Fungicides, Industrial; D006827:Hydantoins; D011758:Pyrroles; D000620:Aminoimidazole Carboxamide; D011494:Protein Kinases; D000071677:Histidine Kinase; C108339:fludioxonil; C033148:iprodione