title: [A case of carcinomatous cardiac tamponade due to breast cancer treated with OK-432 and mitomycin C].
abstract: The patient was a 40-year-old woman who was admitted to our hospital because of severe cough and dyspnea due to multiple lung metastases from breast cancer, who had undergone Auchincloss operation for right breast cancer about five years earlier. While systemic chemotherapy (CAF) was started after admission,she presented with cardiac tamponade. A cardiac echogram revealed marked retention of pericardial effusion. Pericardiocentesis was carried out, and the cytology of the effusion showed class V, resulting in the diagnosis of carcinomatous cardiac tamponade due to breast cancer. She was treated with intrapericardial chemotherapy using OK-432 and mitomycin C (MMC), and has not suffered from pericardial effusion after the intrapericardial chemotherapy. Intrapericardial chemotherapy using OK-432 and MMC may be very useful for malignant pericardial effusion.
authors.affiliation: Dept. of General Surgery, Iizuka Hospital.
authors.forename: Shigeki
authors.initials: S
authors.lastname: Wakiyama
authors.forename: Ken
authors.initials: K
authors.lastname: Shirabe
authors.forename: Takashi
authors.initials: T
authors.lastname: Nagaie
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D018270:Carcinoma, Ductal, Breast / Q000188:drug therapy* / Q000556:secondary; D002305:Cardiac Tamponade / Q000188:drug therapy* / Q000209:etiology; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy / Q000556:secondary; D016685:Mitomycin / Q000008:administration & dosage; D010490:Pericardial Effusion / Q000188:drug therapy / Q000209:etiology / Q000628:therapy*; D020519:Pericardiocentesis; D010844:Picibanil / Q000008:administration & dosage; D011788:Quality of Life
chemical_list: D010844:Picibanil; D016685:Mitomycin