Antiproliferative and antioxidant activities of a tricin acylated glycoside from sugarcane (Saccharum officinarum) juice.
From sugarcane juice, a flavone, identified by spectroscopic methods as tricin-7-O-beta-(6''-methoxycinnamic)-glucoside, was isolated, in addition to orientin. The tricin derivative was shown to have antioxidant activity higher than Trolox by means of the DPPH assay and lower by the beta-carotene/linoleic acid system. It showed in vitro antiproliferative activity against several human cancer cell lines, with higher selectivity toward cells of the breast resistant NIC/ADR line.
Duarte-Almeida
Joaquim Mauricio
JM
Laboratório de Química, Bioquímica e Biologia Molecular de Alimentos, Departamento de Alimentos e Nutrição Experimental, FCF, Universidade de São Paulo, CP 66083, CEP 05314-970, São Paulo, SP, Brazil. maudal@usp.br
Negri
Giuseppina
G
Salatino
Antonio
A
de Carvalho
João Ernesto
JE
Lajolo
Franco Maria
FM
D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002839:Chromans / Q000494:pharmacology; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D031786:Saccharum / Q000737:chemistry*
D000970:Antineoplastic Agents; D000975:Antioxidants; D002839:Chromans; D005419:Flavonoids; D005960:Glucosides; C521864:tricin-7-O-beta-(6''-methoxycinnamic)glucoside; C065886:orientin; C010643:6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid