title: Control of virus infection by tumour suppressors.
abstract: An increasing number of tumour suppressor genes are induced by interferons (IFNs) and may play an important role in the control of cell proliferation induced by this cytokine. In addition, pathways triggered by both tumour suppressors and IFN converge as common targets for non-related tumour viruses. The inhibition of the IFN response by animal viruses is explained by the fundamental role that IFN plays to control virus infection. However, the reasons why many viruses, including those that do not require the replication of the host, target tumour suppressor pathways are varied and are still under investigation. Here we review those findings that support that tumour suppressors may have a role in the control of virus infection.
authors.affiliation: Departamento de Microbiología II, Facultad de Farmacia, Universidad Complutense de Madrid, Plaza Ramón y Cajal s/n, Madrid, Spain.
authors.forename: César
authors.initials: C
authors.lastname: Muñoz-Fontela
authors.forename: María A
authors.initials: MA
authors.lastname: García
authors.forename: Manuel
authors.initials: M
authors.lastname: Collado
authors.forename: Laura
authors.initials: L
authors.lastname: Marcos-Villar
authors.forename: Pedro
authors.initials: P
authors.lastname: Gallego
authors.forename: Mariano
authors.initials: M
authors.lastname: Esteban
authors.forename: Carmen
authors.initials: C
authors.lastname: Rivas
mesh_terms: D000818:Animals; D015967:Gene Expression Regulation, Viral / Q000502:physiology*; D016147:Genes, Tumor Suppressor; D006801:Humans; D007372:Interferons / Q000037:antagonists & inhibitors / Q000502:physiology; D025521:Tumor Suppressor Proteins / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology*; D014777:Virus Diseases / Q000201:enzymology / Q000235:genetics / Q000378:metabolism* / Q000517:prevention & control*
chemical_list: D025521:Tumor Suppressor Proteins; D007372:Interferons