Prenatal cocaine exposure: cardiorespiratory function and resilience.
Cardiac vagal tone (VT) was studied as a resilience factor in children prenatally exposed to cocaine and nonexposed controls (n = 550). A cumulative risk index was derived and used to classify children as high versus low risk. VT was measured during mildly stressful observations at 1 and 36 months of age. Children were classified as having consistently high, consistently low, or fluctuating VT. Risk and VT interacted to predict adaptive behaviors. For high-risk children, low VT was related to higher ratings of adaptive behaviors. This finding suggests that regulatory functioning, as indexed by VT, may be a protective factor in prenatal CE.
Sheinkopf
Stephen J
SJ
Brown Medical School, Providence, Rhode Island, USA. Stephen_Sheinkopf@brown.edu
Lagasse
Linda L
LL
Lester
Barry M
BM
Liu
Jing
J
Seifer
Ronald
R
Bauer
Charles R
CR
Shankaran
Seetha
S
Bada
Henrietta
H
Higgins
Rosemary
R
DAS
Abhik
A
D000223:Adaptation, Psychological; D003042:Cocaine / Q000009:adverse effects*; D019970:Cocaine-Related Disorders; D005260:Female; D006321:Heart / Q000502:physiology*; D006339:Heart Rate / Q000502:physiology*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000523:psychology*; D012119:Respiration; D012307:Risk Factors
D003042:Cocaine