title: Surgical therapies for pulmonary arterial hypertension.
abstract: Surgical therapies for the treatment of pulmonary arterial hypertension typically are reserved for patients who are deemed to be refractory to medical therapy and have evidence of progressive right-sided heart failure. Atrial septostomy, a primarily palliative procedure, may stave off hemodynamic collapse from right-sided heart failure long enough to permit a more definitive surgical treatment such as lung or combined heart-lung transplantation. This article discusses indications for and results of atrial septostomy and lung and heart-lung transplantation in patients who have pulmonary arterial hypertension.
authors.affiliation: Lung Transplantation Program, Pulmonary, Allergy and Critical Care Division, University of Pennsylvania Medical Center, 828 West Gates Building, 3600 Spruce Street, Philadelphia, PA 19104, USA. sagerj@uphs.upenn.edu
authors.forename: Jeffrey S
authors.initials: JS
authors.lastname: Sager
authors.forename: Vivek N
authors.initials: VN
authors.lastname: Ahya
mesh_terms: D015150:Echocardiography, Doppler; D006084:Graft Rejection / Q000503:physiopathology; D006346:Heart Septum / Q000601:surgery; D016041:Heart-Lung Transplantation; D006801:Humans; D006976:Hypertension, Pulmonary / Q000601:surgery*; D016040:Lung Transplantation / Q000276:immunology / Q000502:physiology; D018579:Patient Selection; D011183:Postoperative Complications / Q000453:epidemiology; D011788:Quality of Life