title: Detection and spread of Escherichia coli possessing the plasmid-borne carbapenemase KPC-2 in Brooklyn, New York.
abstract: A carbapenem-resistant isolate of Escherichia coli was identified that possessed a 23-kb plasmid encoding Klebsiella pneumoniae carbapenemase type 2 (KPC-2). A subsequent surveillance study involving hospitals in Brooklyn, New York, revealed that, among 1417 E. coli isolates, 7 isolates (from 3 hospitals) possessed bla(KPC-2). E. coli possessing KPC-2 is emerging in our region, and improved methods for detection are urgently needed.
authors.affiliation: State University of New York Downstate Medical Center, Brooklyn, NY 11203, USA. sbratu@downstate.edu
authors.forename: Simona
authors.initials: S
authors.lastname: Bratu
authors.forename: Steven
authors.initials: S
authors.lastname: Brooks
authors.forename: Sibte
authors.initials: S
authors.lastname: Burney
authors.forename: Sandeep
authors.initials: S
authors.lastname: Kochar
authors.forename: Jyoti
authors.initials: J
authors.lastname: Gupta
authors.forename: David
authors.initials: D
authors.lastname: Landman
authors.forename: John
authors.initials: J
authors.lastname: Quale
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001426:Bacterial Proteins / Q000378:metabolism*; D015780:Carbapenems / Q000494:pharmacology; D003428:Cross Infection / Q000453:epidemiology / Q000382:microbiology; D004196:Disease Outbreaks; D024881:Drug Resistance, Bacterial; D004926:Escherichia coli / Q000145:classification / Q000201:enzymology*; D004927:Escherichia coli Infections / Q000175:diagnosis / Q000453:epidemiology*; D006801:Humans; D015994:Incidence; D008297:Male; D008826:Microbial Sensitivity Tests; D009519:New York City / Q000453:epidemiology; D016133:Polymerase Chain Reaction; D011159:Population Surveillance; D001618:beta-Lactamases / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D015780:Carbapenems; C491478:beta-lactamase KPC-2; D001618:beta-Lactamases; C063912:carbapenemase