title: Anti-inflammatory and analgesic effects of Hedychium coronarium Koen.
abstract: Successive hexane, chloroform and methanol extracts of the rhizome of Hedychium coronarium Koen. (HC) were subjected to evaluate analgesic and anti-inflammatory activities in animal model. In acetic acid-induced writhing test, the chloroform and methanol extract at doses of 400 mg/kg body weight elicited 27.23 and 40.59% inhibition of writhing reflex respectively. Both the chloroform and methanol extracts showed significant elongation of tail flick time (41.15 and 61.32% elongation respectively) at 400 mg/kg body weight. In carrageenan induced rat paw edema test, the chloroform and methanol extracts at a dose of 400 mg/kg body weight showed statistically significant (P<0.01) inhibition of paw edema by 27.46 and 32.48%, respectively at the third hour after carrageenan injection.
authors.affiliation: Department of Molecular and Cell Biology, College of Pharmacy, Seoul National University, Seoul 151-742, Korea.
authors.forename: Sangeeta
authors.initials: S
authors.lastname: Shrotriya
authors.forename: Mohammad S
authors.initials: MS
authors.lastname: Ali
authors.forename: Achinto
authors.initials: A
authors.lastname: Saha
authors.forename: Sitesh C
authors.initials: SC
authors.lastname: Bachar
authors.forename: Md S
authors.initials: MS
authors.lastname: Islam
mesh_terms: D019342:Acetic Acid; D000700:Analgesics / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology* / Q000627:therapeutic use; D002351:Carrageenan; D004195:Disease Models, Animal; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control*; D051379:Mice; D010146:Pain / Q000139:chemically induced / Q000517:prevention & control*; D010147:Pain Measurement; D017288:Pain Threshold / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology; D051381:Rats; D020318:Rats, Long-Evans; D027343:Rhizome; D013997:Time Factors; D030521:Zingiberaceae
chemical_list: D000700:Analgesics; D000893:Anti-Inflammatory Agents; D010936:Plant Extracts; D002351:Carrageenan; D019342:Acetic Acid