title: What are the characteristics of patients with severe, symptomatic, mitral regurgitation who are denied surgery?
abstract: OBJECTIVE
  To identify the proportion and characteristics of patients with severe symptomatic mitral regurgitation (MR) who are denied surgery.
  
  
  RESULTS
  In the Euro Heart Survey on valvular heart disease, 396 patients had severe symptomatic MR as assessed by Doppler-echocardiography (grade > or =3/4) and New York Heart Association class II or greater. Patient characteristics were analysed according to the decision to operate or not. A decision not to operate was taken in 193 patients (49%). In multivariable analysis, decreased left ventricular ejection fraction (LVEF) [OR = 1.39 per 10% decrease, 95% CI (1.17-1.66), P = 0.0002], non-ischaemic aetiology [OR = 4.44, 95% CI (1.96-10.76), P = 0.0006], older age [OR = 1.40 per 10-year increase, 95% CI (1.15-1.72), P = 0.001], increased Charlson comorbidity index [OR = 1.38 per 1 point increase, 95% CI (1.12-1.72), P = 0.004], and grade 3 MR [OR = 2.23, 95% CI (1.28-3.29), P = 0.005] were associated with the decision not to operate. One-year survival was 96.0 +/- 1.4% in patients with a positive decision for intervention vs. 89.5 +/- 2.3% in those with a negative decision (P = 0.02).
  
  
  CONCLUSIONS
  Surgery was denied in 49% of patients with severe symptomatic MR. Impaired LVEF, older age, and comorbidity were the most striking characteristics of patients who were denied surgery. The weight of age and LVEF in the decision do not seem justified according to current knowledge.
authors.affiliation: Cardiology Department, Bichat Hospital, AP-HP, 46 rue Henri Huchard, 75018 Paris, France.
authors.forename: Mariana
authors.initials: M
authors.lastname: Mirabel
authors.forename: Bernard
authors.initials: B
authors.lastname: Iung
authors.forename: Gabriel
authors.initials: G
authors.lastname: Baron
authors.forename: David
authors.initials: D
authors.lastname: Messika-Zeitoun
authors.forename: Delphine
authors.initials: D
authors.lastname: Détaint
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Vanoverschelde
authors.forename: Eric G
authors.initials: EG
authors.lastname: Butchart
authors.forename: Philippe
authors.initials: P
authors.lastname: Ravaud
authors.forename: Alec
authors.initials: A
authors.lastname: Vahanian
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D015897:Comorbidity; D001026:Coronary Artery Bypass / Q000706:statistics & numerical data; D003657:Decision Making; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D008944:Mitral Valve Insufficiency / Q000209:etiology / Q000401:mortality / Q000601:surgery*; D012017:Referral and Consultation; D016079:Refusal to Treat / Q000706:statistics & numerical data*; D012044:Regression Analysis; D013318:Stroke Volume; D016019:Survival Analysis; D016896:Treatment Outcome