Malignant ganglioneuroma arising from mediastinal mixed germ cell tumor.
Mixed germ cell tumors with non-germ cell malignant components rarely occur in the anterior mediastinum. We report a case of a 34-year-old man who presented with an anterior mediastinum mass. Mixed germ cell tumor was initially diagnosed based on the pathologic findings of germinoma on thoracoscopic biopsy and clinical findings of elevated serum alpha-fetoprotein and beta-human chorionic gonadotropin. The patient received preoperative chemotherapy and subsequent complete resection of the residual tumor. Pathologic examination of the excised specimen showed predominantly malignant ganglioneuroma and small residual foci of teratoma. To our knowledge, this is the first reported case of a malignant ganglioneuroma arising from mediastinal mixed germ cell tumor.
Chen
Pi-Yu
PY
Department of Pathology, Chia-Yi Veterans General Hospital, Taiwan, ROC.
Chen
Winby York-Kwan
WY
Ho
Donald M T
DM
Pan
Chin-Chen
CC
D000328:Adult; D005729:Ganglioneuroma / Q000209:etiology* / Q000473:pathology / Q000628:therapy; D006801:Humans; D008297:Male; D008479:Mediastinal Neoplasms / Q000150:complications* / Q000473:pathology; D009373:Neoplasms, Germ Cell and Embryonal / Q000150:complications* / Q000473:pathology