title: Galactoxylomannan does not exhibit cross-reactivity in the platelia Aspergillus enzyme immunoassay.
abstract: Given the recent report of a false-positive result in the Platelia Aspergillus enzyme immunoassay in a patient with cryptococcosis and in yeast extracts and purified galactoxylomannan of Cryptococcus neoformans, we evaluated culture extracts, purified polysaccharides, clinical specimens, and specimens from animals following experimental infection. Our results revealed no cross-reactions.
authors.affiliation: Albert Einstein College of Medicine, Bronx, NY 10461, USA.
authors.forename: Magdia
authors.initials: M
authors.lastname: De Jesus
authors.forename: Emily
authors.initials: E
authors.lastname: Hackett
authors.forename: Michelle
authors.initials: M
authors.lastname: Durkin
authors.forename: Patricia
authors.initials: P
authors.lastname: Connolly
authors.forename: Arturo
authors.initials: A
authors.lastname: Casadevall
authors.forename: Ruta
authors.initials: R
authors.lastname: Petraitiene
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Walsh
authors.forename: L Joseph
authors.initials: LJ
authors.lastname: Wheat
mesh_terms: D000818:Animals; D001232:Aspergillus fumigatus / Q000276:immunology*; D002240:Carbohydrate Sequence; D003429:Cross Reactions; D003455:Cryptococcus neoformans / Q000276:immunology*; D007124:Immunoenzyme Techniques; D051379:Mice; D008807:Mice, Inbred BALB C; D011134:Polysaccharides; D011135:Polysaccharides, Bacterial / Q000737:chemistry* / Q000276:immunology*; D011817:Rabbits
chemical_list: D011134:Polysaccharides; D011135:Polysaccharides, Bacterial; C043689:galactoxylomannan