title: MR colonography without bowel purgation for the assessment of inflammatory bowel diseases: diagnostic accuracy and patient acceptance.
abstract: BACKGROUND
  The purpose of this pilot study was to assess the diagnostic accuracy of MR colonography (MRC) without bowel cleansing regarding its ability to quantify inflammatory bowel disease (IBD). In addition, patient acceptance was compared with conventional colonoscopy (CC).
  
  
  METHODS
  In all, 29 patients with IBD (17 ulcerative colitis; 12 Crohn's disease) were included. While CC was performed after bowel cleansing as the gold standard, MRC was based on a fecal tagging technique and performed 48-72 hours prior to CC. The presence of inflammation in each of 7 ileocolonic segments was rated for every procedure. Patients evaluated both modalities and dedicated aspects of the examination according to a 10-point-scale (1 = good, 10 = poor acceptance). Furthermore, preferences for future examinations were investigated.
  
  
  RESULTS
  Inflammatory segments were found by means of CC in 23 and by MRC in 14 patients. Overall sensitivity and specificity of MRC in a segment-based detection were 32% and 88%, respectively. Concerning severely inflamed segments, sensitivity increased to 53% for MRC. Overall acceptance of CC was significantly higher compared to MRC (mean value (mv) for MRT = 6.0; CC = 4.1; P = 0.003). For MRC, the placement of the rectal tube (mv = 7.3), and for CC bowel purgation (mv = 6.5), were rated as the most unpleasant. A total of 67% of patients voted for CC as the favorable tool for future examinations.
  
  
  CONCLUSIONS
  The presented data indicate that 'fecal tagging MRC' is not suitable for an adequate quantification of inflammatory diseases of the large bowel. Furthermore, overall acceptance of endoscopic colonoscopy was superior to MRC.
authors.affiliation: Department of Internal and Integrative Medicine, Kliniken Essen-Mitte, Germany. jost.langhorst@gmx.de
authors.forename: Jost
authors.initials: J
authors.lastname: Langhorst
authors.forename: Christiane A
authors.initials: CA
authors.lastname: Kühle
authors.forename: Waleed
authors.initials: W
authors.lastname: Ajaj
authors.forename: Michael
authors.initials: M
authors.lastname: Nüfer
authors.forename: Jörg
authors.initials: J
authors.lastname: Barkhausen
authors.forename: Andreas
authors.initials: A
authors.lastname: Michalsen
authors.forename: Gustav J
authors.initials: GJ
authors.lastname: Dobos
authors.forename: Thomas C
authors.initials: TC
authors.lastname: Lauenstein
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D003093:Colitis, Ulcerative / Q000175:diagnosis; D003113:Colonoscopy; D003424:Crohn Disease / Q000175:diagnosis; D005260:Female; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000175:diagnosis*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D010342:Patient Acceptance of Health Care; D010865:Pilot Projects; D012680:Sensitivity and Specificity