title: A case of Lhermitte-Duclos disease presenting high FDG uptake on FDG-PET/CT.
abstract: Lhermitte-Duclos Disease (LDD) is a rare cerebellar lesion that has long been controversial as to whether the entity is a hamartoma, a malformation, or a neoplasm. Recent advances in metabolic imaging and molecular biology have unveiled biological features of LDD and a close relationship between LDD and Cowden disease. Adult onset LDD is now considered identical to Cowden disease in a US guideline. We present a case of LDD, in which high fluorodeoxy glucose (FDG) uptake was shown on PET/CT. We performed dual time point scans, in which a delayed scan exhibited more intense FDG uptake by the hamartomatous lesion than an early scan. We must remain aware of the possibility of LDD when intense accumulation is observed in a cerebellar lesion on FDG-PET/CT imaging.
authors.affiliation: Department of Radiology, Saiseikai Matsusaka General Hospital, Matsusaka, Japan.
authors.forename: Toshio
authors.initials: T
authors.lastname: Nakagawa
authors.forename: Masayuki
authors.initials: M
authors.lastname: Maeda
authors.forename: Mikiyoshi
authors.initials: M
authors.lastname: Kato
authors.forename: Naohiro
authors.initials: N
authors.lastname: Terada
authors.forename: Shigetoshi
authors.initials: S
authors.lastname: Shimizu
authors.forename: Yoshito
authors.initials: Y
authors.lastname: Morooka
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nakano
authors.forename: Kan
authors.initials: K
authors.lastname: Takeda
mesh_terms: D000236:Adenoma / Q000150:complications; D000368:Aged; D002531:Cerebellum / Q000000981:diagnostic imaging* / Q000473:pathology; D019788:Fluorodeoxyglucose F18; D006223:Hamartoma Syndrome, Multiple / Q000150:complications / Q000000981:diagnostic imaging* / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D013964:Thyroid Neoplasms / Q000150:complications; D014057:Tomography, X-Ray Computed
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18