title: Four-dimensional single breathhold magnetic resonance imaging using kt-BLAST enables reliable assessment of left- and right-ventricular volumes and mass.
abstract: OBJECTIVE
  To prospectively determine the accuracy of four-dimensional (4D) kt-broad-use linear acquisition speed-up technique (BLAST) accelerated MRI (kt-BLAST) for the assessment of left-ventricular (LV) volumes and mass as well as right-ventricular (RV) volumes in comparison to standard multiple breathhold cine imaging.
  
  
  METHODS
  A total of 40 patients with suspected or known coronary artery disease (CAD) underwent cardiac MRI. In each patient a standard multislice cine steady-state free precession (SSFP) sequence was performed with complete ventricular coverage during multiple breathholds. Additionally, a kt-BLAST-accelerated 4D sequence with complete ventricular coverage was acquired during one single breathhold. For comparison of SSFP and kt-BLAST, the following LV parameters were determined: end-diastolic and end-systolic volumes, ejection fraction, end-diastolic diameter and mass. For comparison of RV dimensions, end-diastolic and end-systolic volumes and ejection fraction were assessed.
  
  
  RESULTS
  LV volumes, ejection fraction, diameter, and mass showed a strong correlation between SSFP and kt-BLAST (r=0.98-0.99; P<0.01). In addition, RV parameters demonstrated a high correlation (r=0.97-0.98; P<0.01). For all parameters, the calculated bias between both methods was found to be minimal (0.4-4%).
  
  
  CONCLUSIONS
  4D kt-BLAST-accelerated MRI enabled the accurate assessment of LV and RV quantitative parameters during one single breathhold when compared to standard multislice, multiple breathhold SSFP imaging.
authors.affiliation: Department of Internal Medicine/Cardiology, German Heart Institute Berlin, Berlin, Germany. jahnke@dhzb.de
authors.forename: Cosima
authors.initials: C
authors.lastname: Jahnke
authors.forename: Eike
authors.initials: E
authors.lastname: Nagel
authors.forename: Rolf
authors.initials: R
authors.lastname: Gebker
authors.forename: Axel
authors.initials: A
authors.lastname: Bornstedt
authors.forename: Bernhard
authors.initials: B
authors.lastname: Schnackenburg
authors.forename: Sebastian
authors.initials: S
authors.lastname: Kozerke
authors.forename: Eckart
authors.initials: E
authors.lastname: Fleck
authors.forename: Ingo
authors.initials: I
authors.lastname: Paetsch
mesh_terms: D003327:Coronary Disease / Q000473:pathology* / Q000503:physiopathology; D006352:Heart Ventricles / Q000033:anatomy & histology*; D006801:Humans; D019028:Magnetic Resonance Imaging, Cine / Q000379:methods*; D015203:Reproducibility of Results; D012119:Respiration; D013318:Stroke Volume; D016276:Ventricular Function; D016277:Ventricular Function, Left