Testosterone patch improves ovarian follicular response to gonadotrophins in a patient with Kallmann's syndrome: a case report.
Achieving ovulation in women with Kallmann's syndrome requires both exogenous FSH and LH to successfully stimulate follicular maturation and ovarian steroidogenesis. We present a case of a woman with Kallmann's syndrome, who had poor ovarian response to stimulation by exogenous gonadotrophins. When she was given testosterone by patch before initiation of gonadotrophins, her stimulation dramatically improved. Once we ceased to pretreat her cycle with testosterone, she again had a poor stimulation. This suggests that testosterone administration may be a useful adjunct in improving ovarian response to gonadotrophins in Kallmann's syndrome patients.
Sipe
Christopher S
CS
Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, University of Iowa Hospitals and Clinics, Iowa City, IA 52242-1080, USA.
Van Voorhis
Bradley J
BJ
D000279:Administration, Cutaneous; D000328:Adult; D006063:Chorionic Gonadotropin / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000188:drug therapy* / Q000209:etiology; D017436:Kallmann Syndrome / Q000150:complications*; D006080:Ovarian Follicle / Q000187:drug effects*; D010062:Ovulation Induction / Q000379:methods*; D013739:Testosterone / Q000008:administration & dosage*; D017211:Treatment Failure
D006063:Chorionic Gonadotropin; D013739:Testosterone