Synthesis of 6- and 9-alkylaminomethyl furoflavones as gastroprotective agents.
The synthesis of 9- and 6-alkylaminomethyl furoflavones 5a, b, 9a-c, 13a, b, 15a-g and 18 from the naturally occurring chromones visnagin and khellin. Gastroprotective potency of these compounds in the ethanol damage model was determined. The results indicate that, through appropriate substitution, furoflavones can be obtained that are gastroprotective.
Ragab
Fatma A
FA
Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, El-Kasr El-Aini Street, Cairo 11562, Egypt.
Hassan
Ghaneya S
GS
Yossef
Hanan A
HA
Hashem
Hanna A
HA
D000818:Animals; D000897:Anti-Ulcer Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002867:Chromones / Q000737:chemistry; D000431:Ethanol; D047309:Flavones / Q000138:chemical synthesis* / Q000494:pharmacology; D007666:Khellin / Q000031:analogs & derivatives / Q000737:chemistry; D020011:Protective Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D013276:Stomach Ulcer / Q000139:chemically induced / Q000517:prevention & control*; D013329:Structure-Activity Relationship
D000897:Anti-Ulcer Agents; D002867:Chromones; D047309:Flavones; D020011:Protective Agents; D000431:Ethanol; D007666:Khellin; C044999:visnagin