title: [Osteoporosis as a first manifestation of systemic mastocytosis. Study of 6 cases].
abstract: OBJECTIVE
  We describe 6 cases of secondary osteoporosis due to systemic mastocytosis diagnosed in the last 6 years.
  
  
  RESULTS
  Three females and 3 males, age range: 47-66 years, diagnosed with osteoporosis were subsequently diagnosed with systemic mastocytosis. Diagnosis delay: 0.5-17 years. Cutaneous involvement was present in 3 patients, hematologic involvement in 2 patients and gastrointestinal involvement in 2 patients. Histamine levels in urine were elevated in all cases. Four patients had fractures. Treatment with bisphosphonates was started. After 3 years the values of bone mineral density (BMD) improved in the 5 patients evaluated. Two patients had new vertebral fractures and started teriparatide.
  
  
  CONCLUSIONS
  Osteoporosis is an unfrequent initial manifestation of systemic mastocytosis. These patients have a high risk of fractures. Our results suggest that although bisphosphonates improve the bone mineral density the risk of fractures persists.
authors.affiliation: Servicio de Reumatología, CAP Bages, Centre Hospitalari, Manresa, Barcelona, España. 35814ms@lcomb.es
authors.forename: Meritxell
authors.initials: M
authors.lastname: Sallés
authors.forename: Susana
authors.initials: S
authors.lastname: Holgado
authors.forename: José-Tomás
authors.initials: JT
authors.lastname: Navarro
authors.forename: Josep-Maria
authors.initials: JM
authors.lastname: Ribera
authors.forename: Elena
authors.initials: E
authors.lastname: Riera
authors.forename: Fuensanta
authors.initials: F
authors.lastname: Millà
authors.forename: Xavier
authors.initials: X
authors.lastname: Tena
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D034721:Mastocytosis, Systemic / Q000150:complications*; D008875:Middle Aged; D010024:Osteoporosis / Q000209:etiology*