title: Reversal of rocuronium-induced (1.2 mg kg-1) profound neuromuscular block by accidental high dose of sugammadex (40 mg kg-1).
abstract: Sugammadex is the first selective relaxant binding agent and reverses rocuronium-induced neuromuscular block. A case is reported in which a patient accidentally received a high dose of sugammadex (40 mg kg-1) to reverse a rocuronium-induced (1.2 mg kg-1) profound neuromuscular block. A fast and efficient recovery from profound neuromuscular block was achieved and no adverse events or other safety concerns were reported.
authors.affiliation: Department of Anaesthesiology, Erasmus University Medical Centre, Rotterdam, and Martini Hospital Groningen, The Netherlands.
authors.forename: A L
authors.initials: AL
authors.lastname: Molina
authors.forename: H D
authors.initials: HD
authors.lastname: de Boer
authors.forename: M
authors.initials: M
authors.lastname: Klimek
authors.forename: M
authors.initials: M
authors.lastname: Heeringa
authors.forename: J
authors.initials: J
authors.lastname: Klein
mesh_terms: D000328:Adult; D000732:Androstanols / Q000037:antagonists & inhibitors*; D006801:Humans; D008297:Male; D008508:Medication Errors; D009469:Neuromuscular Junction / Q000187:drug effects / Q000502:physiology; D003473:Neuromuscular Nondepolarizing Agents / Q000037:antagonists & inhibitors*; D000077123:Rocuronium; D000077122:Sugammadex; D047408:gamma-Cyclodextrins / Q000494:pharmacology* / Q000506:poisoning
chemical_list: D000732:Androstanols; D003473:Neuromuscular Nondepolarizing Agents; D047408:gamma-Cyclodextrins; D000077122:Sugammadex; D000077123:Rocuronium