Endoluminal suturing may overcome the limitations of clip closure of a gaping wide colon perforation (with videos).
BACKGROUND
It is unclear whether large gaping perforations of the colon can be closed by the endoluminal route.


OBJECTIVE
To evaluate the feasibility and the outcome of closure of large perforations of colon with clips and sutures by using through-the-endoscope novel devices.


METHODS
Prospective animal study.


METHODS
University hospital.


METHODS
Ten pigs.


METHODS
Closure of a 4-cm full-thickness colon perforation freshly created by an insulated-tip knife with the InScope Multi-Clip Applier (n = 6) and with the tissue approximation device (n = 4).


METHODS
(a) Technical feasibility of closure, (b) clinical monitoring for 2 weeks, (c) necropsy (day 14), (d) healing by a dye-leak test and histology.


RESULTS
Endoluminal closure of a 4-cm-long colon perforation was successful in 9 of 10 animals. The clips failed to close a gaping wide colon perforation in 1 animal. The sutures were successful in the closure of both nongaping and gaping perforations. Successful closure resulted in a leakproof sealing at 2 weeks and prevented clinical peritonitis in all the animals in the clip-closure group and in 3 of 4 animals in the suture-closure group. Necropsy at 2 weeks revealed mild peritonitis in 2 of the 5 animals in the clip closure group and in 2 of the 4 animals in the suture-closure group; none developed fecal peritonitis.


CONCLUSIONS
None.


CONCLUSIONS
Endoluminal closure of a 4-cm colon perforation with clips was successful in the majority of cases. Sutures were useful in the closure of gaping colon perforations that could not be closed with clips.
Raju
Gottumukkala S
GS
Center for Endoscopic Research, Training, and Innovation (CERTAIN), University of Texas Medical Branch, Galveston, Texas 77555-0764, USA.
Shibukawa
Goro
G
Ahmed
Ijaz
I
Brining
Douglas
D
Poussard
Allison
A
Xiao
Shu-Yuan
SY
Coe
Jonathan
J
Cropper
Mike
M
Martin
Dave
D
Hull
Joanne
J
D000818:Animals; D003106:Colon / Q000293:injuries* / Q000601:surgery*; D020685:Colonoscopes; D003113:Colonoscopy; D004195:Disease Models, Animal; D004867:Equipment Design; D005240:Feasibility Studies; D007416:Intestinal Perforation / Q000601:surgery*; D011446:Prospective Studies; D013525:Surgical Instruments; D013536:Suture Techniques / Q000295:instrumentation*; D013552:Swine; D016896:Treatment Outcome; D014945:Wound Healing