[The methodological aspects of off-line sampling of exhaled air for nitric oxide measurement in Japanese].
The measurement of exhaled nitric oxide (eNO) is a non-invasive biomarker of bronchial inflammation. Despite the usefulness of eNO measurement, NO analyzers are too expensive for widespread use by general practitioners. In comparison, the off-line (bag collection) method of eNO measurement may be more useful. In Japan, however, there have been few studies about eNO in asthmatics using the off-line method. This study shows methodological aspects of the off-line method. Briefly, with a SIEVERS bag collection kit, we recommend that the flow rate and pressure level of exhaled air should be 70 ml/sec and 10 cm H2O, respectively and that the sampled air should be measured within 12 hours.
Tsuburai
Takahiro
T
Clinical Research Center for Allergy and Rheumatology, National Hospital Organization, Sagamihara National Hospital.
Suzuki
Shunsuke
S
Tsurikisawa
Naomi
N
Higashi
Noritaka
N
Higashi
Ai
A
Oshikata
Chiyako
C
Ono
Emiko
E
Morita
Sonoko
S
Ohtomo
Mamoru
M
Maeda
Yuji
Y
Ikehara
Kunihiko
K
Taniguchi
Masami
M
Akiyama
Kazuo
K
D000328:Adult; D001944:Breath Tests / Q000295:instrumentation; D001991:Bronchitis / Q000175:diagnosis* / Q000473:pathology; D045853:Exhalation / Q000502:physiology*; D005260:Female; D006801:Humans; D007249:Inflammation / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000032:analysis*; D012494:Sampling Studies
D009569:Nitric Oxide