Th1/Th2 cross-regulation and the discovery of IL-10.
In the late 1980s, Tim Mosmann and colleagues isolated functionally distinct T helper (Th)-1 and Th2 clones, and provided evidence that these two subsets were mutually inhibitory. Knowledge of the inhibition led to the discovery that Th2 cells make IL-10 to suppress Th1 cells.
Bashyam
Hema
H
hbashyam@rockefeller.edu
D000486:Allergy and Immunology / Q000266:history*; D049673:History, 20th Century; D007111:Immunity, Cellular / Q000276:immunology*; D016753:Interleukin-10 / Q000276:immunology*; D018448:Models, Immunological; D018417:Th1 Cells / Q000276:immunology*; D018418:Th2 Cells / Q000276:immunology*
D016753:Interleukin-10