Rheology of sodium hyaluronate saline solutions for ophthalmic use.
The aim of this work was to investigate the rheological properties of different saline solutions of sodium hyaluronate (NaHA) with special interest for medical applications. The experimental results were compared with literature data for commercial ophthalmic viscosurgical devices (OVDs) used in cataract surgery. We offer some tools to tailor the rheological behavior of OVDs for different purposes. We have investigated to which extent surgical requirements can be fulfilled by adjusting either the molecular weight of NaHA or its concentration, parameters that are in some respects equivalent but not in others. Furthermore, we demonstrate that moduli and complex viscosities of NaHA saline solutions are adequately falling on master curves, using either empirical or calculated shift factors, the latest ones being based on a modified Rouse model.
Calciu-Rusu
Daniela
D
Institut für Physikalische Chemie, Johannes Gutenberg-Universität Mainz, Jakob Welder-Weg 13, D-55099 Mainz, Germany. daniela.rusu@mines-paris.org
Rothfuss
Ernst
E
Eckelt
John
J
Haase
Tanja
T
Dick
H Burkhard
HB
Wolf
Bernhard A
BA
D006820:Hyaluronic Acid / Q000737:chemistry*; D009883:Ophthalmic Solutions / Q000737:chemistry*; D012212:Rheology; D012965:Sodium Chloride / Q000737:chemistry*; D012996:Solutions / Q000737:chemistry
D009883:Ophthalmic Solutions; D012996:Solutions; D012965:Sodium Chloride; D006820:Hyaluronic Acid