Signal transduction induced in endothelial cells by growth factor receptors involved in angiogenesis.
New vessel formation during development and in the adult is triggered by concerted signals of largely endothelial-specific receptors for ligands of the VEGF, angiopoietin and ephrin families. The signals and genes induced by these receptors operate in the context of additional signals transduced by non-endothelial specific growth factor receptors, inflammatory cytokine receptors as well as adhesion molecules. We summarize here available data on characteristic signaling of the VEGF receptor-2 and the current state of knowledge regarding the additional different receptor tyrosine kinases of the VEGF, Tie and Ephrin receptor families. Furthermore, the potential cross-talk with signals induced by other growth factors and inflammatory cytokines as well as the modulation by VE-cadherin is discussed.
Hofer
Erhard
E
Department of Vascular Biology and Thrombosis Research, Center for Biomolecular Medicine and Pharmacology, Medical University of Vienna, Vienna, Austria. erhard.hofer@meduniwien.ac.at
Schweighofer
Bernhard
B
D042682:Angiopoietins / Q000378:metabolism; D000818:Animals; D015703:Antigens, CD / Q000378:metabolism; D015820:Cadherins / Q000378:metabolism; D016207:Cytokines / Q000378:metabolism; D042783:Endothelial Cells / Q000378:metabolism*; D036342:Ephrins / Q000378:metabolism; D006801:Humans; D018919:Neovascularization, Physiologic; D020239:Receptor Cross-Talk; D036081:Receptors, Eph Family / Q000378:metabolism; D017978:Receptors, Growth Factor / Q000378:metabolism*; D042764:Receptors, TIE / Q000378:metabolism; D015398:Signal Transduction; D040301:Vascular Endothelial Growth Factor Receptor-2 / Q000378:metabolism; D042442:Vascular Endothelial Growth Factors / Q000378:metabolism; D000099152:Cadherin 5
D042682:Angiopoietins; D015703:Antigens, CD; D015820:Cadherins; D016207:Cytokines; D036342:Ephrins; D036081:Receptors, Eph Family; D017978:Receptors, Growth Factor; D042764:Receptors, TIE; D040301:Vascular Endothelial Growth Factor Receptor-2; D042442:Vascular Endothelial Growth Factors; D000099152:Cadherin 5