title: Effect on partial pressure of oxygen in arterial blood in percutaneous vertebroplasty.
abstract: OBJECTIVE
  The purpose of this study is to estimate the change in partial pressure of oxygen (Pao(2)) during percutaneous vertebroplasty and also to examine the factors related to the change in Pao(2).
  
  
  METHODS
  We retrospectively reviewed preprocedural and postprocedural Pao(2) of 59 consecutive patients who underwent percutaneous vertebroplasty between November 2003 and April 2005 (11 men and 48 women; age range, 50-93; mean age, 75 years). Fifty-four patients were treated for osteoporosis-related fractures and 5 had malignant disease. Percutaneous vertebroplasty was performed in a conventional manner under local anesthetics and conscious sedation. Preprocedural and postprocedural blood drawing was performed 5 days to 30 minutes before percutaneous vertebroplasty and also at 30 minutes after the injection of bone cement. The difference between preprocedural and postprocedural data of Pao(2) was correlated with patients' age, number of treated vertebral bodies, presence of cement leakage, and presence of malignant neoplasm for each patient.
  
  
  RESULTS
  Mean pre-Pao(2) and post-Pao(2) were 80.9 +/- 1.4 and 70.6 +/- 1.3 mm Hg (mean +/- SE) respectively (P = .0001). Using analysis of variance, there was a significant difference according to the number of vertebral bodies. There was a positive trend of decrease in Pao(2) according to the number of vertebral bodies during percutaneous vertebroplasty. Using multiple linear regression and after adjusting by preprocedural Pao(2) and other variables, the number of vertebral bodies was still highly significant.
  
  
  CONCLUSIONS
  Pao(2) decreases during percutaneous vertebroplasty, and there is a correlation between the number of treated vertebral bodies and decrease in Pao(2).
authors.affiliation: Department of Radiology, St. Luke's International Hospital, Tokyo, Japan. akuemura@luke.or.jp
authors.forename: A
authors.initials: A
authors.lastname: Uemura
authors.forename: Y
authors.initials: Y
authors.lastname: Numaguchi
authors.forename: M
authors.initials: M
authors.lastname: Matsusako
authors.forename: N
authors.initials: N
authors.lastname: Kobayashi
authors.forename: Y
authors.initials: Y
authors.lastname: Saida
authors.forename: M
authors.initials: M
authors.lastname: Rahman
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000772:Anesthesia, Local; D001843:Bone Cements / Q000627:therapeutic use; D016292:Procedural Sedation; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D019637:Orthopedic Procedures; D010024:Osteoporosis / Q000150:complications; D010100:Oxygen / Q000097:blood*; D010313:Partial Pressure; D019904:Polymethyl Methacrylate / Q000627:therapeutic use; D012189:Retrospective Studies; D012720:Severity of Illness Index; D016103:Spinal Fractures / Q000097:blood* / Q000209:etiology / Q000628:therapy*; D013997:Time Factors
chemical_list: D001843:Bone Cements; D019904:Polymethyl Methacrylate; D010100:Oxygen