title: Preterm labour and birth: a survey of clinical practice regarding use of tocolytics, antenatal corticosteroids, and progesterone.
abstract: OBJECTIVE
  We wished to determine prescribing practices of obstetricians in Canada regarding tocolytics, antenatal corticosteroids, and progesterone for women at increased risk of preterm labour and birth, and to determine whether these practices changed between 1997-98 and 2004.
  
  
  METHODS
  Two cross-sectional surveys of Canadian obstetricians were conducted. The initial survey was in 1997-98 (N = 1313); the follow-up survey was in 2004 (N = 1508).
  
  
  RESULTS
  Response rates were 46.4% in 1997-98 and 43.3% in 2004. Most respondents reported that they prescribed tocolytics to women with signs and symptoms of preterm labour (97.4% in 1997-98; 92.2% in 2004; P < 0.001) but use had decreased. In 1997-98, 20.0% of respondents used tocolytics for > 48 hours during one course of treatment, whereas in 2004, only 9.6% did this (P = 0.06). The tocolytic prescribed most frequently was magnesium sulphate in 1997-98 (40.6% of respondents), whereas in 2004, it was indomethacin (47.5% of respondents). The use of repeat courses of antenatal corticosteroids decreased from 72.9% in 1997-98 to 18.7% in 2004 (P < 0.001). In 2004, only a few respondents (7.0%) prescribed progesterone for women at increased risk of preterm birth.
  
  
  CONCLUSIONS
  Most Canadian obstetricians continue to use tocolytics for women in preterm labour, although use has decreased over time, and the most frequently prescribed tocolytic has changed from magnesium sulphate to indomethacin. The use of repeat courses of antenatal corticosteroids decreased substantially during this time, and in 2004, progesterone was not in frequent use.
authors.affiliation: Department of Obstetrics and Gynaecology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto ON.
authors.forename: Dini
authors.initials: D
authors.lastname: Hui
authors.affiliation: Department of Obstetrics and Gynaecology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto ON.
authors.forename: Grace
authors.initials: G
authors.lastname: Liu
authors.affiliation: Maternal, Infant and Reproductive Health Research Unit, Centre for Research in Women's Health, Women's College Hospital, University of Toronto, Toronto ON.
authors.forename: Edna
authors.initials: E
authors.lastname: Kavuma
authors.affiliation: Maternal, Infant and Reproductive Health Research Unit, Centre for Research in Women's Health, Women's College Hospital, University of Toronto, Toronto ON.
authors.forename: Sheila A
authors.initials: SA
authors.lastname: Hewson
authors.affiliation: Maternal, Infant and Reproductive Health Research Unit, Centre for Research in Women's Health, Women's College Hospital, University of Toronto, Toronto ON.
authors.forename: Darren
authors.initials: D
authors.lastname: McKay
authors.affiliation: Department of Obstetrics and Gynaecology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto ON.
authors.forename: Mary E
authors.initials: ME
authors.lastname: Hannah
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use*; D003430:Cross-Sectional Studies; D005260:Female; D019538:Health Care Surveys; D006801:Humans; D008297:Male; D007752:Obstetric Labor, Premature / Q000517:prevention & control*; D009774:Obstetrics; D010818:Practice Patterns, Physicians'; D011247:Pregnancy; D047928:Premature Birth / Q000517:prevention & control; D011295:Prenatal Care; D011374:Progesterone / Q000627:therapeutic use*; D011795:Surveys and Questionnaires; D015149:Tocolytic Agents / Q000627:therapeutic use*
chemical_list: D000305:Adrenal Cortex Hormones; D015149:Tocolytic Agents; D011374:Progesterone