title: Intermittent administration of the circulating form of human parathyroid hormone (hPTH-1-37) prevents bone loss in ovariectomized rats.
abstract: The circulating hormonal form of human parathyroid hormone (hPTH-1-37) has been assessed in vitro as well as in vivo in the ovariectomized rat, a model for postmenopausal osteoporosis. In vitro, hPTH-1-37 induces a dose-dependent cAMP formation and increases vitality as well as alkaline phosphatase activity in UMR106 osteosarcoma cells. Differentiation and proliferation of osteoclasts in rat bone marrow-derived stem cell preparations are decreased. Daily hPTH-1-37 s.c. administration in ovariectomized rats for 60 days results in augmented formation of new bone, in amplified femural bone density, and in thickening of the calvaria.
authors.affiliation: IPF PharmaCeuticals GmbH, Hannover, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Stephan
authors.forename: J
authors.initials: J
authors.lastname: van de Flierdt
authors.forename: S
authors.initials: S
authors.lastname: Loumi
authors.forename: G
authors.initials: G
authors.lastname: Bonaterra
authors.forename: F-J
authors.initials: FJ
authors.lastname: Kramer
authors.forename: M
authors.initials: M
authors.lastname: Fehr
authors.forename: H-C
authors.initials: HC
authors.lastname: Tillmann
authors.forename: W G
authors.initials: WG
authors.lastname: Forssmann
authors.forename: Erik
authors.initials: E
authors.lastname: Maronde
mesh_terms: D000469:Alkaline Phosphatase / Q000378:metabolism; D000704:Analysis of Variance; D000818:Animals; D045744:Cell Line, Tumor; D000242:Cyclic AMP / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005269:Femur / Q000000981:diagnostic imaging / Q000187:drug effects / Q000254:growth & development; D006801:Humans; D015663:Osteoporosis, Postmenopausal / Q000188:drug therapy*; D010052:Ovariectomy; D010281:Parathyroid Hormone / Q000494:pharmacology / Q000627:therapeutic use*; D010446:Peptide Fragments / Q000494:pharmacology / Q000627:therapeutic use*; D011859:Radiography; D051381:Rats; D017208:Rats, Wistar; D012886:Skull / Q000187:drug effects / Q000254:growth & development
chemical_list: D010281:Parathyroid Hormone; D010446:Peptide Fragments; C094316:parathyroid hormone (1-37); D000242:Cyclic AMP; D000469:Alkaline Phosphatase