title: Papular acantholytic dyskeratosis of the anogenital area with positive direct immunofluorescence results.
abstract: Acantholytic dyskeratosis is a distinct histological pattern characterized by hyperkeratotic and parakeratotic epidermis with intraepidermal clefts harbouring acantholytic and dyskeratotic keratinocytes. This histopathological pattern is uncommon in dermatoses of the anogenital region. We report a 30-year-old woman who had numerous smooth whitish papules on the labia majora, perineum and perianal region, which coalesced into plaques in some areas. Microscopically, the lesions showed prominent suprabasal and intraspinous acantholysis with dyskeratotic keratinocytes. Direct immunofluorescence examination revealed intercellular Ig G and C(3) within the epidermis. We were unable to find a similar case of papular acantholytic dyskeratosis of the anogenital area with positive direct immunofluorescence findings reported in the literature, thus in this report, the clinicopathological features of a unique case are presented.
authors.affiliation: Department of Dermatology, Faculty of Medicine, Dokuz Eylül University, Izmir, Turkey.
authors.forename: A T
authors.initials: AT
authors.lastname: Güneş
authors.forename: T
authors.initials: T
authors.lastname: Ilknur
authors.forename: U
authors.initials: U
authors.lastname: Pabuççuoğlu
authors.forename: B
authors.initials: B
authors.lastname: Lebe
authors.forename: D D
authors.initials: DD
authors.lastname: Altiner
mesh_terms: D000051:Acantholysis / Q000473:pathology*; D000328:Adult; D003937:Diagnosis, Differential; D005260:Female; D019085:Fluorescent Antibody Technique, Direct; D005831:Genital Diseases, Female / Q000473:pathology*; D006801:Humans; D007642:Keratosis / Q000473:pathology*