title: Absence of relationship between MTTP haplotypes and longevity.
abstract: BACKGROUND
  Polymorphisms for the microsomal triglyceride transfer protein (MTTP) gene have been associated with longevity and with lower risk for cardiovascular mortality. However, the association of MTTP with longevity has been contested in a large German collection of nonagenarians and centenarians.
  
  
  METHODS
  We made a detailed characterization of MTTP haplotype carrier status in a cohort of 1398 old men and women (mean age 78 years) and a population-based cohort (n = 777) of younger controls (mean age 40 years) in Oxford, England.
  
  
  RESULTS
  There were no significant differences in haplotypes for MTTP gene between the younger and older age groups.
  
  
  CONCLUSIONS
  This study, which adopted a more detailed genetic analysis of the MTTP gene in a large case-control study of older people provides reliable evidence against any significant association of the MTTP gene with longevity.
authors.affiliation: Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, UK.
authors.forename: Matt J
authors.initials: MJ
authors.lastname: Neville
authors.forename: Robert
authors.initials: R
authors.lastname: Clarke
authors.forename: John Grimley
authors.initials: JG
authors.lastname: Evans
authors.forename: David C
authors.initials: DC
authors.lastname: Rubinsztein
authors.forename: Fredrik
authors.initials: F
authors.lastname: Karpe
mesh_terms: D000328:Adult; D000368:Aged; D002318:Cardiovascular Diseases / Q000235:genetics; D002352:Carrier Proteins / Q000235:genetics*; D015331:Cohort Studies; D005260:Female; D005819:Genetic Markers / Q000235:genetics; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium; D008136:Longevity / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D012306:Risk; D018401:Sample Size; D006113:United Kingdom
chemical_list: D002352:Carrier Proteins; D005819:Genetic Markers; C106092:microsomal triglyceride transfer protein