Is PBEF/visfatin/Nampt an authentic adipokine relevant to the metabolic syndrome?
Adipokines are peptides secreted by adipose tissue that affect whole-body energy metabolism. Their dysregulated production in obesity has implicated them as important mediators in the pathogenesis of obesity-related risk factors for diabetes and cardiovascular disease. PBEF/visfatin/Nampt has recently been described as a novel adipokine with insulin mimetic properties. However, whether it is an authentic adipokine relevant to the metabolic syndrome remains a matter of some debate.
Sethi
Jaswinder K
JK
Department of Clinical Biochemistry, University of Cambridge, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 2QR, UK. jks30@cam.ac.uk
D000273:Adipose Tissue / Q000378:metabolism; D016207:Cytokines / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism; D004734:Energy Metabolism; D006801:Humans; D006943:Hyperglycemia / Q000378:metabolism; D006949:Hyperlipidemias / Q000378:metabolism; D006973:Hypertension / Q000378:metabolism; D024821:Metabolic Syndrome / Q000378:metabolism*; D054409:Nicotinamide Phosphoribosyltransferase; D009765:Obesity / Q000378:metabolism
D016207:Cytokines; D054409:Nicotinamide Phosphoribosyltransferase; C085455:nicotinamide phosphoribosyltransferase, human