title: Rituximab in the adjuvant treatment of pemphigus vulgaris: a prospective open-label pilot study in five patients.
abstract: BACKGROUND
  Rituximab is a monoclonal antibody directed against the CD20 antigen expressed on B lymphocytes. There are reports of its efficacy in the treatment of autoimmune diseases, including pemphigus.
  
  
  OBJECTIVE
  Prospectively to evaluate the efficacy of rituximab as adjuvant treatment for pemphigus vulgaris (PV).
  
  
  METHODS
  Patients with PV were treated with intravenous rituximab (375 mg m(-2)) weekly for 4 weeks in this prospective open-label pilot study. Other concurrent immunosuppression was continued.
  
  
  RESULTS
  Of five patients, one achieved complete remission and was able to cease all medication, while two achieved clearance of clinical lesions but continued on systemic therapy. Two patients had progressive disease. Time to response was 2-8 months, with a 13- to 18-month response duration. Response was associated with reduction in serum antiepithelial antibodies. Two patients had significant infectious complications (one developed community-acquired pneumonia associated with delayed-onset neutropenia and the other developed cytomegalovirus infection).
  
  
  CONCLUSIONS
  Rituximab has shown efficacy in the treatment of PV. Patients on multiple immunosuppressives should be closely monitored for infectious complications.
authors.affiliation: Dermatology Service, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
authors.forename: M S Y
authors.initials: MS
authors.lastname: Goh
authors.forename: C
authors.initials: C
authors.lastname: McCormack
authors.forename: H V
authors.initials: HV
authors.lastname: Dinh
authors.forename: B
authors.initials: B
authors.lastname: Welsh
authors.forename: P
authors.initials: P
authors.lastname: Foley
authors.forename: H M
authors.initials: HM
authors.lastname: Prince
mesh_terms: D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D058846:Antibodies, Monoclonal, Murine-Derived; D018941:Antigens, CD19 / Q000097:blood; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D007155:Immunologic Factors / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010392:Pemphigus / Q000188:drug therapy* / Q000276:immunology; D010865:Pilot Projects; D011446:Prospective Studies; D000069283:Rituximab; D016896:Treatment Outcome
chemical_list: D000911:Antibodies, Monoclonal; D058846:Antibodies, Monoclonal, Murine-Derived; D018941:Antigens, CD19; D007155:Immunologic Factors; D000069283:Rituximab