Prognostic significance of adiponectin levels in non-metastatic colorectal cancer.
BACKGROUND
Circulating adiponectin levels are inversely correlated with the risk of colorectal cancer (CRC). This study was designed to evaluate the association between adiponectin levels and the clinicopathological variables of CRC and to analyze the possible prognostic value of adiponectin in predicting relapse-free survival.


METHODS
Baseline adiponectin and serum tumor markers were analyzed in 60 patients with non-metastatic CRC followed-up from time of surgery for at least three years or until relapse.


RESULTS
The median adiponectin levels were lower in CRC patients (8.3 microg/ml) than controls (13.1 microg/ml, p <0.001). Moreover, median adiponectin concentration gradually decreased with increase in tumor stage. Low pre-surgical adiponectin levels were found in 52% of the relapsing patients compared to 26% (p=0.037) of the non-relapsing patients. Logistic regression analysis demonstrated that stage of disease (OR (odds ratio)=15.9, p<O.O1) and low adiponectin levels (OR=4.66, p<0.05) were independent predictors of recurrent disease.


CONCLUSIONS
Low serum adiponectin might represent an adjunctive tool in risk prediction for CRC recurrence.
Ferroni
Patrizia
P
Department of Laboratory Medicine and Advanced Biotechnologies, IRCCS San Raffaele, Via della Pisana 235, 00163, Rome, Italy. patrizia.ferroni@sanraffaele.it
Palmirotta
Raffaele
R
Spila
Antonella
A
Martini
Francesca
F
Raparelli
Valeria
V
Fossile
Emanuela
E
Mariotti
Sabrina
S
Del Monte
Girolamo
G
Buonomo
Oreste
O
Roselli
Mario
M
Guadagni
Fiorella
F
D052242:Adiponectin / Q000097:blood*; D000368:Aged; D015179:Colorectal Neoplasms / Q000097:blood* / Q000473:pathology; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D016015:Logistic Models; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D016017:Odds Ratio; D011379:Prognosis
D052242:Adiponectin