title: Multidimensional fatigue and its correlates in hospitalised advanced cancer patients.
abstract: Although fatigue is a multidimensional concept, multidimensional fatigue is rarely investigated in hospitalised cancer patients. We determined the levels and correlates of multidimensional fatigue in 100 advanced cancer patients admitted for symptom control. Fatigue dimensions were general fatigue (GF), physical fatigue (PF), reduced activity (RA), reduced motivation (RM) and mental fatigue (MF). Investigated correlates were tumour load, prior anti-tumour treatment, medication use, haemoglobin levels, serum biochemical variables, physical symptoms and mood. Median GF, PF and RA scores were very high; median RM and MF scores were moderate, and differed from the GF, PF and RA scores. Multiple regression analyses showed that symptoms and mood correlated with all fatigue dimensions. Each fatigue dimension had different relationships with other factors. Hospitalised advanced cancer patients differ in fatigue levels depending on the fatigue dimension, and each fatigue dimension has different correlates. The results confirm that fatigue should be regarded as a multidimensional concept.
authors.affiliation: VU University Medical Centre, Institute for Research in Extramural Medicine, Department of Public and Occupational Health, Amsterdam, The Netherlands. michael.echteld@vumc.nl
authors.forename: Michael A
authors.initials: MA
authors.lastname: Echteld
authors.forename: Jan
authors.initials: J
authors.lastname: Passchier
authors.forename: Saskia
authors.initials: S
authors.lastname: Teunissen
authors.forename: Susanne
authors.initials: S
authors.lastname: Claessen
authors.forename: Ronald
authors.initials: R
authors.lastname: de Wit
authors.forename: Carin C D
authors.initials: CC
authors.lastname: van der Rijt
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D005221:Fatigue / Q000209:etiology*; D005260:Female; D006760:Hospitalization; D006801:Humans; D008297:Male; D005222:Mental Fatigue / Q000209:etiology*; D008875:Middle Aged; D009042:Motivation; D009369:Neoplasms / Q000150:complications* / Q000523:psychology; D011446:Prospective Studies; D016019:Survival Analysis