[Exploration of the auditory effects of diabetes mellitus using distortion product otoacoustic emissions].
OBJECTIVE
To investigate the effects of diabetes mellitus on amplitude of distortion product otoacoustic emissions ( DPOAE) and whether streptozotocin has ototoxicity or not.


METHODS
Twenty-four SD rats were divided into diabetes mellitus group, insulin therapy group and control group. Diabetes was induced by streptozotocin. The blood glucose of insulin group was controlled by insulin. The amplitude of DPOAE was tested before streptozotocin injection and 3 months, 5 months after injection, respectively.


RESULTS
The amplitude of DPOAE in diabetes rats was decreased in 3 months and there was statistical significance (P <0. 05) in 1038, 4126 and 5200 Hz, while obviously reduced in 5 months in all frequencies and there was also statistical significance (P <0. 01). The amplitude of DPOAE in all frequencies lacked of any significance between insulin therapy group and control group.


CONCLUSIONS
Diabetes mellitus could induce the amplitude of DPOAE decreasing. Streptozotocin had not evident toxicity for inner ear.
Xiao
Da-jiang
DJ
Department of Otorhinolaryngology, Wuxi Second People's Hospital, Wuxi 214002, China.
Zhang
Yong-sheng
YS
Zhang
Yu-hai
YH
D000818:Animals; D001786:Blood Glucose / Q000032:analysis*; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology*; D007758:Ear, Inner / Q000187:drug effects / Q000503:physiopathology; D006320:Hearing Tests; D008297:Male; D017084:Otoacoustic Emissions, Spontaneous; D051381:Rats; D017207:Rats, Sprague-Dawley; D013311:Streptozocin / Q000633:toxicity
D001786:Blood Glucose; D013311:Streptozocin