Vascular endothelial growth factor family of ligands and receptors: review.
VEGF signaling often represents a critical rate-limiting step in physiological angiogenesis. The VEGF family comprises seven secreted glycoproteins that are designated VEGF-A, VEGF-B, VEGF-C, VEGF-D, VEGF-E, placental growth factor (PlGF) and VEGF-F. The VEGF family members bind their cognate receptors. The receptors identified so far are designated VEGFR-1, VEGFR-2, VEGFR-3 and the neuropilins (NP-1 and NP-2). We review in this article the biology of the VEGF ligands and the receptors.
Otrock
Zaher K
ZK
Division of Hematology/Oncology, Department of Internal Medicine, American University of Beirut-Medical Center, Beirut 1107 2802, Lebanon.
Makarem
Jawad A
JA
Shamseddine
Ali I
AI
D000818:Animals; D006801:Humans; D008024:Ligands; D009389:Neovascularization, Pathologic; D018919:Neovascularization, Physiologic; D040262:Receptors, Vascular Endothelial Growth Factor; D042442:Vascular Endothelial Growth Factors
D008024:Ligands; D042442:Vascular Endothelial Growth Factors; D040262:Receptors, Vascular Endothelial Growth Factor