Cytotoxic alkylpiperidine alkaloids from the Brazilian marine sponge Pachychalina alcaloidifera.
Four bis-piperidine alkaloids, madangamine F (1), haliclonacyclamine F (2). and arenosclerins D (3) and E (4), have been isolated from the marine sponge Pachychalina alcaloidifera and have been identified by analysis of spectroscopic data. The alkaloids displayed cytotoxic activity against different cancer cell lines. These results support the hypothesis of a common biogenetic origin for the Haplosclerida bis-piperidine and bis-pyridine alkaloids.
de Oliveira
Jaine H H L
JH
Instituto de Química de São Carlos, Universidade de São Paulo, CP 780, CEP 13560-970, São Carlos, SP, Brazil.
Nascimento
Andréa M
AM
Kossuga
Miriam H
MH
Cavalcanti
Bruno C
BC
Pessoa
Claudia O
CO
Moraes
Manoel O
MO
Macedo
Mario L
ML
Ferreira
Antonio G
AG
Hajdu
Eduardo
E
Pinheiro
Ulisses S
US
Berlinck
Roberto G S
RG
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001938:Brazil; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006801:Humans; D008386:Marine Biology; D015394:Molecular Structure; D010880:Piperidines / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D011161:Porifera / Q000737:chemistry*
D000470:Alkaloids; D000970:Antineoplastic Agents; D010880:Piperidines