title: LymphTF-DB: a database of transcription factors involved in lymphocyte development.
abstract: B and T cells develop following a similar early stepwise progression to later stages where multiple developmental options are available. These developmental regimes necessitate differential gene expression regulated by a large number of transcription factors (TFs). The resultant burgeoning amount of information has opened a knowledge gap between TF activities during lymphocyte development and a researcher's experiments. We have created the LymphTF database (DB) to fill this gap. This DB holds interactions between individual TFs and their specific targets at a given developmental time. By storing such interactions as a function of developmental progression, we hope to advance the elucidation of regulatory networks that guide lymphocyte development. Besides queries for TF-target gene interactions in developmental stages, the DB provides a graphical representation of downloadable target gene regulatory sequences with locations of the transcriptional start sites and TF-binding sites. The LymphTF-DB can be accessed freely on the web at http://www.iupui.edu/~tfinterx/.
authors.affiliation: School of Informatics, Indiana University-Purdue University Indianapolis, 719 Indiana Avenue, Indianapolis, IN 46202, USA.
authors.forename: P J
authors.initials: PJ
authors.lastname: Childress
authors.forename: R L
authors.initials: RL
authors.lastname: Fletcher
authors.forename: N B
authors.initials: NB
authors.lastname: Perumal
mesh_terms: D000818:Animals; D030541:Databases, Genetic; D006801:Humans; D020407:Internet; D008214:Lymphocytes / Q000276:immunology / Q000502:physiology*; D014157:Transcription Factors / Q000145:classification / Q000235:genetics* / Q000378:metabolism*; D014158:Transcription, Genetic
chemical_list: D014157:Transcription Factors