Additional support for linkage of schizophrenia and bipolar disorder to chromosome 3q29.
After publishing a genome scan and follow-up fine mapping, suggesting schizophrenia and bipolar disorder linkage to chromosome 3q29, we now genotyped 11 additional SNPs (single nucleotide polymorphisms), in order to narrow down a potential candidate region. Linkage was performed using the GENEHUNTER program version 2.1r3. A NPL score Z(all) of 3.891 (p=0.000156) was observed with SNP rs225. In short, we found significant linkage scores most telomeric on chromosome 3q29, spanning 3.46 Mbp (7 SNPs).
Schosser
Alexandra
A
Department of General Psychiatry, University Hospital for Psychiatry, Medical University Vienna, Austria. alexandra.schosser@meduniwien.ac.at
Fuchs
Karoline
K
Scharl
Theresa
T
Leisch
Friedrich
F
Bailer
Ursula
U
Kasper
Siegfried
S
Sieghart
Werner
W
Hornik
Kurt
K
Aschauer
Harald N
HN
D002874:Chromosome Mapping; D002893:Chromosomes, Human, Pair 3; D017931:DNA Primers; D005819:Genetic Markers; D005838:Genotype; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D015203:Reproducibility of Results; D012559:Schizophrenia / Q000235:genetics*; D016615:Telomere / Q000235:genetics
D017931:DNA Primers; D005819:Genetic Markers