Synthesis, structure and biological activity of nitroxide malonate methanofullerenes.
Two nitroxide methanofullerenes was synthesized for the first time, and their structures and biological activities studied. It was shown by X-ray single crystal analysis that the methanofullerene with two nitroxide groups forms a 1 : 2 inclusion complex with chloroform and has a nearly tetrahedral (diamond-like) arrangement of fullerene-fullerene interactions in the crystal. For the first time, it has been found that malonate nitroxide methanofullerene in combination with the known anticancer drug cyclophosphamide (CPA) shows high antitumor activity against leukemia P-388.
Gubskaya
Valentina P
VP
A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Research Center of the Russian Academy of Sciences, 8 ul. Acad. Arbuzova, 420088 Kazan, Russian Federation.
Berezhnaya
Lucia Sh
LSh
Gubaidullin
Aidar T
AT
Faingold
Irina I
II
Kotelnikova
Raisa A
RA
Konovalova
Nina P
NP
Morozov
Vladimir I
VI
Litvinov
Igor A
IA
Nuretdinov
Ildus A
IA
D000818:Animals; D002851:Chromatography, High Pressure Liquid; D018360:Crystallography, X-Ray; D003520:Cyclophosphamide / Q000627:therapeutic use; D004578:Electron Spin Resonance Spectroscopy; D037741:Fullerenes / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use; D007938:Leukemia / Q000188:drug therapy; D008297:Male; D051379:Mice; D008958:Models, Molecular; D023041:Xenograft Model Antitumor Assays
D037741:Fullerenes; D003520:Cyclophosphamide