title: Endothelial function in patients with migraine during the interictal period.
abstract: OBJECTIVE
  The aim of this study is to evaluate endothelial function in migraineurs subjects during the asymptomatic period.
  
  
  BACKGROUND
  Migraine has been proposed as a risk factor for cerebrovascular events. The underlying mechanisms that relate these 2 pathologies are unknown. Nitric oxide (NO) has been proposed as the final causative molecule of migraine. Increased NO metabolites concentrations have been reported in migraineurs subjects during acute migraine attacks, but there is no evidence indicating alterations in endothelial NO release during the symptom free period in theses subjects.
  
  
  METHODS
  Fifty migraineurs subjects and 25 healthy subjects matched by gender and age were included. Every subject underwent a complete examination that included medical history, physical examination, resting electrocardiogram, forearm flow-mediated vasodilation (FMD), blood determinations of fasting nitrates and nitrites (NO(2) (-)+ NO(3) (-)), glucose, lipid profile, creatinine, C-reactive protein, and blood cell count.
  
  
  RESULTS
  No differences in FMD or NO(2) (-)+ NO(3) (-) were detected among groups. The only difference between migraineurs and control subjects was a higher mean blood pressure 92.1 (8.8) mmHg versus 86.7 (8.2) mmHg P= .01.
  
  
  CONCLUSIONS
  The endothelial function is not altered during the interictal period in migraineurs subjects.
authors.affiliation: Instituto de Investigaciones, Grupo de Ciencias Neurovasculares, Grupo de Investigación en Sistema Nervioso Autónomo, Fundación Cardiovascular de Colombia, Floridablanca, Colombia.
authors.forename: Federico A
authors.initials: FA
authors.lastname: Silva
authors.forename: Christian F
authors.initials: CF
authors.lastname: Rueda-Clausen
authors.forename: Sandra Y
authors.initials: SY
authors.lastname: Silva
authors.forename: Juan G
authors.initials: JG
authors.lastname: Zarruk
authors.forename: Juan C
authors.initials: JC
authors.lastname: Guzmán
authors.forename: Carlos A
authors.initials: CA
authors.lastname: Morillo
authors.forename: Boris
authors.initials: B
authors.lastname: Vesga
authors.forename: Gustavo
authors.initials: G
authors.lastname: Pradilla
authors.forename: Mildred
authors.initials: M
authors.lastname: Flórez
authors.forename: Patricio
authors.initials: P
authors.lastname: López-Jaramillo
mesh_terms: D000328:Adult; D001794:Blood Pressure / Q000502:physiology; D016022:Case-Control Studies; D004730:Endothelium, Vascular / Q000502:physiology*; D005260:Female; D005542:Forearm / Q000098:blood supply; D006801:Humans; D008297:Male; D008881:Migraine Disorders / Q000503:physiopathology*; D009566:Nitrates / Q000097:blood; D009573:Nitrites / Q000097:blood; D012039:Regional Blood Flow / Q000502:physiology; D014664:Vasodilation / Q000502:physiology*
chemical_list: D009566:Nitrates; D009573:Nitrites