A mouse model to study tau pathology related with tau phosphorylation and assembly.
The role of tau phosphorylation and tau aggregation in the pathology of a transgenic mouse model that overexpresses GSK-3beta and FTDP-17 tau has been analyzed. In that model we have suggested a possible role for tau phosphorylation, but not for tau aggregation, in the cognitive impairment found in the transgenic mouse.
Engel
Tobias
T
Centro de Biología Molecular "Severo Ochoa", CSIC/UAM, 28049 Madrid, Spain.
Lucas
José J
JJ
Hernández
Félix
F
Avila
Jesús
J
D000375:Aging / Q000378:metabolism / Q000473:pathology; D000818:Animals; D001522:Behavior, Animal / Q000502:physiology; D003072:Cognition Disorders / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology; D003704:Dementia / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology; D018891:Dentate Gyrus / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D004195:Disease Models, Animal; D018450:Disease Progression; D038362:Glycogen Synthase Kinase 3 / Q000235:genetics / Q000378:metabolism*; D000071679:Glycogen Synthase Kinase 3 beta; D006624:Hippocampus / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D016874:Neurofibrillary Tangles / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D009483:Neuropsychological Tests; D010766:Phosphorylation; D017966:Pyramidal Cells / Q000378:metabolism / Q000473:pathology; D024801:Tauopathies / Q000235:genetics / Q000378:metabolism* / Q000503:physiopathology; D016875:tau Proteins / Q000096:biosynthesis / Q000235:genetics / Q000378:metabolism*
C054369:MAPT protein, human; D016875:tau Proteins; C000605506:GSK3B protein, human; D000071679:Glycogen Synthase Kinase 3 beta; C000605507:Gsk3b protein, mouse; D038362:Glycogen Synthase Kinase 3