title: A histological study of the cardiac conduction system in canine cases of mitral valve endocardiosis with complete atrioventricular block.
abstract: The cardiac conduction system was examined histologically in four canine cases of endocardiosis of the mitral valve (MV) with complete atrioventricular (AV) block. In all cases, moderate to severe reduction of the conduction fibres due to fibrous or fibro-fatty replacement was observed in the penetrating and branching portions of the AV bundle. In addition, degenerative and fibrotic lesions were commonly seen at the upper portions of the left and right bundle branches. These changes in the AV conduction system were associated with marked degeneration and fibrosis of the base of the central fibrous body and the upper part of the ventricular septum. The degenerative and sclerotic changes of the AV junctional region, affecting the AV bundle and bundle branches, were qualitatively similar to those in age-matched control dogs, but were more severe. It is possible that the pathological process occurred as a result of ageing and may have been exaggerated or accelerated by the abnormal mechanical forces created by excessive motion of the prolapsed MV and the long-term haemodynamic stresses of mitral regurgitation, resulting in interruption of the AV conduction system to produce complete AV block. Conduction abnormalities represent a possible complication in some canine cases of MV endocardiosis.
authors.affiliation: Departments of; Veterinary Surgery, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu, Tokyo 183-8509, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Kaneshige
authors.forename: N
authors.initials: N
authors.lastname: Machida
authors.forename: S
authors.initials: S
authors.lastname: Yamamoto
authors.forename: S
authors.initials: S
authors.lastname: Nakao
authors.forename: Y
authors.initials: Y
authors.lastname: Yamane
mesh_terms: D000818:Animals; D002036:Bundle of His / Q000473:pathology; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D004562:Electrocardiography / Q000662:veterinary; D004696:Endocarditis / Q000150:complications / Q000473:pathology / Q000662:veterinary*; D004699:Endocardium / Q000473:pathology*; D005260:Female; D006327:Heart Block / Q000209:etiology / Q000473:pathology / Q000662:veterinary*; D006329:Heart Conduction System / Q000473:pathology*; D008297:Male; D008944:Mitral Valve Insufficiency / Q000150:complications / Q000473:pathology / Q000662:veterinary*