title: Two new depsipeptides from the marine fungus Spicellum roseum.
abstract: Investigation of the secondary metabolites of the marine-derived fungus Spicellum roseum yielded two new cyclohexadepsipeptides, spicellamide A (1) and spicellamide B (2). The structures of 1 and 2 were determined based on extensive evaluations of NMR and MS data. The absolute configuration was deduced after hydrolysis using Marfey's method, chiral chromatography, as well as NOESY and modeling data.
authors.affiliation: Institute for Pharmaceutical Biology, University of Bonn, Bonn, Germany.
authors.forename: Ana
authors.initials: A
authors.lastname: Kralj
authors.forename: Stefan
authors.initials: S
authors.lastname: Kehraus
authors.forename: Anja
authors.initials: A
authors.lastname: Krick
authors.forename: Gerhild
authors.initials: G
authors.lastname: van Echten-Deckert
authors.forename: Gabriele M
authors.initials: GM
authors.lastname: König
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor / Q000187:drug effects; D047630:Depsipeptides / Q000737:chemistry / Q000494:pharmacology*; D005658:Fungi; D006801:Humans; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D015394:Molecular Structure; D009447:Neuroblastoma / Q000473:pathology; D008517:Phytotherapy; D051381:Rats
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D047630:Depsipeptides