title: Inhibitory control in children with frontal infarcts related to sickle cell disease.
abstract: Evidence from past studies indicates that children with traumatic brain injury experience difficulties with inhibitory control. Less is known about inhibitory control in children with frontal brain injury related to cerebral infarction. We compared the inhibitory performance of children with frontal infarcts related to sickle cell disease with that of a control group of children with sickle cell disease but no history of cerebral infarction. On a stimulus-response reversal task, children with frontal infarcts made significantly more accuracy errors in the inhibitory condition than controls. Findings from this study and from previous research suggest that impairments in inhibitory control are common following frontal injury in a range of pediatric populations.
authors.affiliation: Department of Psychology, Washington University, St. Louis, MO, USA. research@shawnchrist.com
authors.forename: Shawn E
authors.initials: SE
authors.lastname: Christ
authors.forename: Asif
authors.initials: A
authors.lastname: Moinuddin
authors.forename: Robert C
authors.initials: RC
authors.lastname: McKinstry
authors.forename: Michael
authors.initials: M
authors.lastname: DeBaun
authors.forename: Desirée A
authors.initials: DA
authors.lastname: White
mesh_terms: D000293:Adolescent; D000755:Anemia, Sickle Cell / Q000150:complications* / Q000235:genetics / Q000503:physiopathology; D001288:Attention / Q000502:physiology; D002544:Cerebral Infarction / Q000175:diagnosis* / Q000235:genetics / Q000503:physiopathology; D002648:Child; D005260:Female; D005625:Frontal Lobe / Q000503:physiopathology*; D005838:Genotype; D006451:Hemoglobin, Sickle / Q000235:genetics; D006801:Humans; D007266:Inhibition, Psychological; D008297:Male; D009483:Neuropsychological Tests; D009949:Orientation / Q000502:physiology; D010364:Pattern Recognition, Visual / Q000502:physiology; D011597:Psychomotor Performance / Q000502:physiology; D011930:Reaction Time / Q000502:physiology; D012193:Reversal Learning / Q000502:physiology
chemical_list: D006451:Hemoglobin, Sickle