A fatty-acid synthesis mechanism specialized for parasitism.
Most cells use either a type I or type II synthase to make fatty acids. Trypanosoma brucei, the sleeping sickness parasite, provides the first example of a third mechanism for this process. Trypanosomes use microsomal elongases to synthesize fatty acids de novo, whereas other cells use elongases to make long-chain fatty acids even longer. The modular nature of the pathway allows synthesis of different fatty-acid end products, which have important roles in trypanosome biology. Indeed, this newly discovered mechanism seems ideally suited for the parasitic lifestyle.
Lee
Soo Hee
SH
Department of Biological Chemistry, Johns Hopkins School of Medicine, 725 North Wolfe Street, Baltimore, Maryland 21205, USA.
Stephens
Jennifer L
JL
Englund
Paul T
PT
D000123:Acetyltransferases / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D005075:Biological Evolution; D053898:Biosynthetic Pathways; D056890:Eukaryota / Q000201:enzymology / Q000235:genetics / Q000378:metabolism; D000081031:Fatty Acid Elongases; D064429:Fatty Acid Synthases / Q000235:genetics / Q000378:metabolism; D005227:Fatty Acids / Q000096:biosynthesis*; D005231:Fatty Acids, Unsaturated / Q000096:biosynthesis; D017261:Glycosylphosphatidylinositols / Q000737:chemistry / Q000378:metabolism; D018320:Leishmania major / Q000201:enzymology / Q000235:genetics; D008018:Life Cycle Stages; D008861:Microsomes / Q000201:enzymology*; D008928:Mitochondria / Q000201:enzymology; D014346:Trypanosoma brucei brucei / Q000201:enzymology / Q000235:genetics / Q000254:growth & development / Q000378:metabolism*; D014349:Trypanosoma cruzi / Q000201:enzymology / Q000235:genetics
D005227:Fatty Acids; D005231:Fatty Acids, Unsaturated; D017261:Glycosylphosphatidylinositols; D000123:Acetyltransferases; D000081031:Fatty Acid Elongases; D064429:Fatty Acid Synthases