The trithorax-group protein Lid is a histone H3 trimethyl-Lys4 demethylase.
Recent studies have demonstrated that histone methylation can be dynamically regulated through active demethylation. However, no demethylase specific to histone H3 trimethyl-Lys4 (H3K4me3) has been identified. Here we report that the Drosophila melanogaster protein 'little imaginal discs' (Lid), a JmjC domain-containing trithorax group protein, can demethylate H3K4me3. Consistent with its genetic classification, Lid positively regulates Hox gene expression in S2 cells.
Lee
Nara
N
Howard Hughes Medical Institute, USA.
Zhang
Junyu
J
Klose
Robert J
RJ
Erdjument-Bromage
Hediye
H
Tempst
Paul
P
Jones
Richard S
RS
Zhang
Yi
Y
D000818:Animals; D004268:DNA-Binding Proteins / Q000378:metabolism*; D029721:Drosophila Proteins / Q000737:chemistry / Q000378:metabolism*; D004331:Drosophila melanogaster / Q000166:cytology / Q000201:enzymology*; D056466:Histone Demethylases; D011495:Histone-Lysine N-Methyltransferase / Q000737:chemistry / Q000378:metabolism*; D006657:Histones / Q000378:metabolism*; D007814:Larva / Q000166:cytology; D008239:Lysine / Q000378:metabolism*; D008745:Methylation; D050505:Mutant Proteins / Q000378:metabolism; D017434:Protein Structure, Tertiary; D021381:Protein Transport; D012319:RNA Polymerase II / Q000378:metabolism; D013379:Substrate Specificity; D014157:Transcription Factors / Q000378:metabolism*
D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; D006657:Histones; D050505:Mutant Proteins; D014157:Transcription Factors; C063460:Trl protein, Drosophila; D056466:Histone Demethylases; C518655:Lid protein, Drosophila; D011495:Histone-Lysine N-Methyltransferase; D012319:RNA Polymerase II; D008239:Lysine