title: Expression of chicken interleukin-2 by turkey herpesvirus increases the immune response against Marek's disease virus but fails to increase protection against virulent challenge.
abstract: As Marek's disease virus continues to evolve towards greater virulence, more efficacious vaccines will be required in the future. We expressed chicken interleukin-2 (IL-2) from a turkey herpesvirus (HVT) in an attempt to increase the efficacy of HVT as a vaccine against Marek's disease. The recombinant IL-2/HVT was safe for in ovo vaccination, although it replicated less in the birds compared with the parent HVT strain. Expression of IL-2 increased the neutralizing antibody response against HVT but did not increase the protection against virulent Marek's disease virus challenge.
authors.affiliation: Intervet UK, Walton Manor, Walton, Milton Keynes, Bucks, MK7 7AJ, UK. ian.tarpey@intervet.com
authors.forename: I
authors.initials: I
authors.lastname: Tarpey
authors.forename: P J
authors.initials: PJ
authors.lastname: Davis
authors.forename: P
authors.initials: P
authors.lastname: Sondermeijer
authors.forename: C
authors.initials: C
authors.lastname: van Geffen
authors.forename: I
authors.initials: I
authors.lastname: Verstegen
authors.forename: V E J C
authors.initials: VE
authors.lastname: Schijns
authors.forename: Jill
authors.initials: J
authors.lastname: Kolodsick
authors.forename: R
authors.initials: R
authors.lastname: Sundick
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D002642:Chick Embryo; D002645:Chickens / Q000235:genetics*; D015870:Gene Expression; D026002:Herpesvirus 1, Meleagrid / Q000235:genetics*; D007376:Interleukin-2 / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D025922:Mardivirus / Q000276:immunology / Q000472:pathogenicity*; D008380:Marek Disease / Q000276:immunology* / Q000517:prevention & control / Q000821:virology; D011201:Poultry Diseases / Q000276:immunology / Q000517:prevention & control / Q000821:virology; D014765:Viral Vaccines / Q000009:adverse effects / Q000276:immunology*; D014774:Virulence; D015430:Weight Gain
chemical_list: D000914:Antibodies, Viral; D007376:Interleukin-2; D014765:Viral Vaccines