Association of arsenic exposure during pregnancy with fetal loss and infant death: a cohort study in Bangladesh.
The authors evaluated the effect of arsenic exposure on fetal and infant survival in a cohort of 29,134 pregnancies identified by the health and demographic surveillance system in Matlab, Bangladesh, in 1991-2000. Arsenic exposure, reflected by drinking water history and analysis of arsenic concentrations in tube-well water used by women during pregnancy, was assessed in a separate survey conducted in 2002-2003. Data on vital events, including pregnancy outcome and infant mortality, were collected by monthly surveillance at the household level. The risk of fetal loss and infant death in relation to arsenic exposure was estimated by a Cox proportional hazards model. Drinking tube-well water with more than 50 microg of arsenic per liter during pregnancy significantly increased the risks of fetal loss (relative risk = 1.14, 95% confidence interval: 1.04, 1.25) and infant death (relative risk = 1.17, 95% confidence interval: 1.03, 1.32). There was a significant dose response of arsenic exposure to risk of infant death (p = 0.02). Women of reproductive age should urgently be prioritized for mitigation activities where drinking water is contaminated by arsenic.
Rahman
Anisur
A
International Centre for Diarrhoeal Disease Research, Bangladesh, Mohakhali, Dhaka, Bangladesh.
Vahter
Marie
M
Ekström
Eva-Charlotte
EC
Rahman
Mahfuzar
M
Golam Mustafa
Abu Haider Mohammad
AH
Wahed
Mohammad Abdul
MA
Yunus
Mohammed
M
Persson
Lars-Ake
LA
D000028:Abortion, Induced / Q000706:statistics & numerical data*; D000328:Adult; D020261:Arsenic Poisoning / Q000453:epidemiology*; D001459:Bangladesh / Q000453:epidemiology; D016009:Chi-Square Distribution; D015331:Cohort Studies; D005260:Female; D005313:Fetal Death / Q000453:epidemiology*; D006801:Humans; D007226:Infant Mortality; D007231:Infant, Newborn; D016015:Logistic Models; D011159:Population Surveillance; D011247:Pregnancy; D011256:Pregnancy Outcome / Q000453:epidemiology*; D016016:Proportional Hazards Models; D012307:Risk Factors; D014874:Water Pollutants, Chemical / Q000506:poisoning
D014874:Water Pollutants, Chemical