[Effect of gamma-interferon on hepatic granuloma formation in mice infected by cysticerci of Taenia saginata asiatica].
Immunohistochemical streptavidin biotin-peroxidase complex method was used to investigate the effect of gamma-interferon (IFN-gamma) on the hepatic granuloma formation and liver fibrosis in mice infected with Taenia saginata in Duyun area of Guizhou Province. The results reveal contrary relation between the level of IFN-gamma in the liver and the degree of liver fibrosis (p<0.01). The injection of IFN-gamma considerably decreased (p<0.01) the area and size of granuloma (p<0.01).
Li
Pu
P
Department of Biochemistry, Qiannan Medical College, Duyun 558003, China.
Bao
Huai-en
HE
Rong
Ju-quan
JQ
Shen
Zhen-hua
ZH
Dang
Rong-min
RM
He
Xiao-fei
XF
Wu
Rong
R
Jiang
Shui
S
D000818:Animals; D003551:Cysticercosis / Q000188:drug therapy* / Q000469:parasitology; D003552:Cysticercus / Q000187:drug effects* / Q000254:growth & development; D005260:Female; D006099:Granuloma / Q000188:drug therapy* / Q000469:parasitology; D007150:Immunohistochemistry; D007371:Interferon-gamma / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000469:parasitology; D008109:Liver Diseases, Parasitic / Q000188:drug therapy*; D008297:Male; D051379:Mice; D041202:Taenia saginata / Q000187:drug effects / Q000254:growth & development
D007371:Interferon-gamma