title: Regulatory role of Peyer's patches for the inhibition of OVA-induced allergic diarrhea.
abstract: Intestinal allergic diseases are initiated by aberrant Th2-type immune responses, including elevation of IgE antibodies (Abs) and infiltration of eosinophils. However, little is known about the role of Peyer's patches (PP) in the control of allergic diseases. Using a mouse model for food allergy, we here show that mice lacking PP are more susceptible to disease development and show higher levels of antigen-specific IgE Abs than do PP-intact mice. In our study, we noted that high numbers of eosinophils infiltrated into the small intestine of PP-null mice. In contrast, the PP of intact mice contained regulatory CD4+CD25+ Foxp3+ T cells (Treg) that are known to produce high levels of IL-10, and inhibited the development of allergic diarrhea. PP-intact mice thus developed allergic diarrhea when treated with anti-CD25 or anti-IL-10 monoclonal antibody (mAb) in vivo. These studies demonstrate that PP, as the site where IL-10-producing Treg cells are created, mediate the mucosal regulatory network for the control of undesired allergic responses in the intestine.
authors.affiliation: Division of Mucosal Immunology, The Institute of Medical Science, The University of Tokyo, Tokyo, 108-8639, Japan.
authors.forename: Naoko
authors.initials: N
authors.lastname: Takayama
authors.forename: Osamu
authors.initials: O
authors.lastname: Igarashi
authors.forename: Mi-Na
authors.initials: MN
authors.lastname: Kweon
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kiyono
mesh_terms: D019264:Adoptive Transfer; D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology / Q000494:pharmacology; D000921:Antibody-Producing Cells / Q000737:chemistry / Q000276:immunology; D003967:Diarrhea / Q000276:immunology* / Q000473:pathology; D004804:Eosinophils / Q000276:immunology / Q000473:pathology; D005512:Food Hypersensitivity / Q000276:immunology* / Q000473:pathology; D015870:Gene Expression; D007114:Immunization; D007070:Immunoglobulin A / Q000032:analysis; D007073:Immunoglobulin E / Q000097:blood; D007074:Immunoglobulin G / Q000032:analysis; D016753:Interleukin-10 / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D053645:Interleukin-2 Receptor alpha Subunit / Q000032:analysis / Q000276:immunology; D007421:Intestine, Small / Q000187:drug effects / Q000276:immunology / Q000473:pathology; D007422:Intestines / Q000276:immunology / Q000473:pathology; D007963:Leukocytes, Mononuclear / Q000378:metabolism / Q000637:transplantation; D051379:Mice; D008807:Mice, Inbred BALB C; D009092:Mucous Membrane / Q000166:cytology / Q000276:immunology; D010047:Ovalbumin / Q000276:immunology*; D010581:Peyer's Patches / Q000276:immunology* / Q000378:metabolism; D020395:Receptors, Interleukin-7 / Q000276:immunology; D020133:Reverse Transcriptase Polymerase Chain Reaction; D050378:T-Lymphocytes, Regulatory / Q000737:chemistry / Q000276:immunology / Q000378:metabolism
chemical_list: D000911:Antibodies, Monoclonal; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D053645:Interleukin-2 Receptor alpha Subunit; D020395:Receptors, Interleukin-7; C415350:interleukin-7 receptor, alpha chain; D016753:Interleukin-10; D007073:Immunoglobulin E; D010047:Ovalbumin