Adiponectin as an anti-inflammatory factor.
Obesity is characterized by low-grade systemic inflammation. Adiponectin is an adipose tissue-derived hormone, which is downregulated in obesity. Adiponectin displays protective actions on the development of various obesity-linked diseases. Several clinical studies demonstrate the inverse relationship between plasma adiponectin levels and several inflammatory markers including C-reactive protein. Adiponectin attenuates inflammatory responses to multiple stimuli by modulating signaling pathways in a variety of cell types. The anti-inflammatory properties of adiponectin may be a major component of its beneficial effects on cardiovascular and metabolic disorders including atherosclerosis and insulin resistance. In this review, we focus on the role of adiponectin in regulation of inflammatory response and discuss its potential as an anti-inflammatory marker.
Ouchi
Noriyuki
N
Molecular Cardiology/Whitaker Cardiovascular Institute, Boston University School of Medicine, 715 Albany Street, W611, Boston, MA 02118, USA. nouchi@bu.edu
Walsh
Kenneth
K
D052242:Adiponectin / Q000502:physiology*; D000893:Anti-Inflammatory Agents; D015415:Biomarkers; D002316:Cardiotonic Agents; D006801:Humans; D018836:Inflammation Mediators / Q000502:physiology*
D052242:Adiponectin; D000893:Anti-Inflammatory Agents; D015415:Biomarkers; D002316:Cardiotonic Agents; D018836:Inflammation Mediators