Antimicrobial prenylated anthracene derivatives from the leaves of Harungana madagascariensis.
Three new prenylated anthranoids, harunmadagascarins C (1) and D (2) and kenganthranol D (3), together with three known compounds (4-6) were isolated from the leaves of Harungana madagascariensis. Their structures were assigned by spectroscopic methods and by comparison with literature data. In the three new natural products 1-3, one or two prenyl groups are incorporated in furan, pyran, or cyclohexane rings in four different modes of annulation. Compounds 2, 4, and 6 were strongly active against the Gram-positive Bacillus megaterium.
Kouam
Simeon F
SF
Department of Chemistry, Higher Teachers' Training College, University of Yaounde 1, BP 47, Yaounde, Cameroon. fkouam@uycdc.uninet.cm
Yapna
Diane B
DB
Krohn
Karsten
K
Ngadjui
Bonaventure T
BT
Ngoupayo
Joseph
J
Choudhary
Mohamed I
MI
Schulz
Barbara
B
D000873:Anthracenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001410:Bacillus megaterium / Q000187:drug effects; D002163:Cameroon; D028084:Clusiaceae / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*
D000873:Anthracenes; D000900:Anti-Bacterial Agents; C519745:harunmadagascarin C; C519746:harunmadagascarin D; C519747:kenganthranol D