title: Spindle cell carcinoma of the external auditory meatus with intracranial extension: histological, immunohistochemical and electron microscopic evaluation.
abstract: We present a case of squamous spindle cell carcinoma of the external auditory meatus in a 38-year-old man. The tumour was extended to the inner ear, the temporal bone, the middle cranial fossa and the meningo-cerebral tissue. The surgical intervention of temporo-occipital craniotomy removed most of the neoplasia. At pathologic examination, the tumour showed an undifferentiated spindle cell pattern. Immunohistochemistry with a large antibody panel found a weak positivity only to EMA. The diagnosis was made when the electron microscopy showed rare junctional structures and tonofilaments.
authors.affiliation: ENT Clinic G. Lugli, Department of Ophthalmology and Otolaryngology, Bari, Italy. otorino1@orl.uniba.it
authors.forename: Antonio
authors.initials: A
authors.lastname: Quaranta
authors.forename: Paolo
authors.initials: P
authors.lastname: Berardi
authors.forename: Domenico
authors.initials: D
authors.lastname: Piscitelli
authors.forename: Maria Grazia
authors.initials: MG
authors.lastname: Fiore
authors.forename: Antonello
authors.initials: A
authors.lastname: Calace
authors.forename: Leonardo
authors.initials: L
authors.lastname: Resta
mesh_terms: D000328:Adult; D000912:Antibodies, Neoplasm / Q000276:immunology; D001301:Audiometry, Pure-Tone; D002277:Carcinoma / Q000276:immunology / Q000601:surgery / Q000648:ultrastructure; D035301:Cranial Fossa, Middle / Q000276:immunology / Q000601:surgery / Q000648:ultrastructure; D003937:Diagnosis, Differential; D004428:Ear Neoplasms / Q000276:immunology / Q000601:surgery / Q000648:ultrastructure; D004431:Ear, External / Q000276:immunology / Q000601:surgery / Q000648:ultrastructure; D007758:Ear, Inner / Q000276:immunology / Q000601:surgery / Q000648:ultrastructure; D005158:Facial Paralysis / Q000175:diagnosis; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008578:Meninges / Q000276:immunology / Q000601:surgery / Q000648:ultrastructure; D008854:Microscopy, Electron; D009361:Neoplasm Invasiveness / Q000648:ultrastructure; D009367:Neoplasm Staging; D013506:Otologic Surgical Procedures / Q000379:methods; D013701:Temporal Bone / Q000276:immunology / Q000601:surgery / Q000648:ultrastructure
chemical_list: D000912:Antibodies, Neoplasm