Emerging drugs in neuropathic pain.
Neuropathic pain is a personally devastating and costly condition affecting 3-8% of the population. Existing treatments have limited effectiveness and produce relatively frequent adverse effects. Preclinical research has identified many promising pharmacological targets; however, reliable predictors of success in humans remain elusive. At least 50 new molecular entities have reached clinical development including: glutamate antagonists, cytokine inhibitors, vanilloid-receptor agonists, catecholamine modulators, ion-channel blockers, anticonvulsants, opioids, cannabinoids, COX inhibitors, acteylcholine modulators, adenosine receptor agonists and several miscellaneous drugs. Eight drugs are in Phase III trials at present. Strategies that may show promise over existing treatments include topical therapies, analgesic combinations and, in future, gene-related therapies. Recent years have heralded an explosion of pharmaceutical development in neuropathic pain, reflecting advanced knowledge of neurobiology and a heightened perception of the commercial value of neuropathic pain therapeutics. In the interest of improving patient care, the authors recommend implementing comparative studies throughout the development process in order to demonstrate the increased value of novel agents.
Gilron
Ian
I
Clinical Pain Research, Queen's University, Kingston, Ontario, ON, Canada. gilroni@post.queensu.ca
Coderre
Terence J
TJ
D000241:Adenosine / Q000819:agonists; D000700:Analgesics / Q000627:therapeutic use*; D000701:Analgesics, Opioid / Q000627:therapeutic use; D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use; D002186:Cannabinoids / Q000627:therapeutic use; D002395:Catecholamines / Q000819:agonists / Q000037:antagonists & inhibitors; D002986:Clinical Trials as Topic; D016861:Cyclooxygenase Inhibitors / Q000627:therapeutic use; D018691:Excitatory Amino Acid Antagonists / Q000627:therapeutic use; D006801:Humans; D009437:Neuralgia / Q000188:drug therapy*; D018722:Nicotinic Agonists / Q000627:therapeutic use; D018733:Nicotinic Antagonists / Q000627:therapeutic use; D050916:TRPV Cation Channels / Q000819:agonists
D000700:Analgesics; D000701:Analgesics, Opioid; D000927:Anticonvulsants; D002186:Cannabinoids; D002395:Catecholamines; D016861:Cyclooxygenase Inhibitors; D018691:Excitatory Amino Acid Antagonists; D018722:Nicotinic Agonists; D018733:Nicotinic Antagonists; D050916:TRPV Cation Channels; D000241:Adenosine