title: Growth of the human eye lens.
abstract: OBJECTIVE
  To analyze human lens growth from the accumulation of wet weight as a function of age.
  
  
  METHODS
  Wet weights were assembled for over 1,100 human lenses, ranging in age from 6 months prenatal to 99 years postnatal, and were examined using various growth models. Initially, prenatal and postnatal data were examined separately, to determine the growth modes and then all data were fitted to a single equation.
  
  
  RESULTS
  Variations in weights due to tissue handling procedures and the unavailability of statistical data for averaged sets precluded the use of >500 values in the present analysis. Regression of age on log lens weight for the remaining 614 lenses indicated that, unlike other species, human lens growth appears to take place in two distinct phases. It was found that asymptotic growth during prenatal life and early childhood generates about 149 mg of tissue in a process, which can be modelled with a Gompertz function. Soon after birth, growth becomes linear, dropping to 1.38 mg/year, and this rate is maintained throughout the rest of life. The relationship of lens wet weight with age over the whole of the lifespan could best be described with the expression, W=1.38A(b) + 149exp;[exp;(1.6-3A(c))], where W is lens weight in mg, A(b) is postnatal age in years and A(c) is the time since conception in years. Comparison of 138 male and 64 female lenses indicated that there was no statistically significant difference between male and female lens weights in the linear (adult) growth mode.
  
  
  CONCLUSIONS
  Human lens growth differs from growth in other species in that it occurs in two distinct modes. The first follows a sigmoidal relationship and provides an initial burst of rapid growth during prenatal development with an apparent termination at or shortly after birth. The second growth mode is linear, adding 1.38 mg/year to lens wet weight, throughout life. Because of the variability in available lens wet weight data, further studies, preferably using lens dry weights or protein contents, will be required to establish precisely when the transition from one growth mode to the other occurs. In contrast to previous reports, it was concluded that, like other species, there are no gender differences in human lens weights.
authors.affiliation: Institute for Eye Research, Sydney, Australia. raugustn@bigpond.net.au
authors.forename: Robert C
authors.initials: RC
authors.lastname: Augusteyn
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D002648:Child; D002675:Child, Preschool; D047108:Embryonic Development; D005260:Female; D005333:Fetus / Q000033:anatomy & histology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007908:Lens, Crystalline / Q000033:anatomy & histology / Q000196:embryology* / Q000254:growth & development*; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D009929:Organ Size