title: Biokinetic modelling of natural thorium in humans by ingestion.
abstract: The retention of naturally occurring thorium (228Th, 230Th, 232Th) in model compartments and its daily urinary and faecal excretion after acute and chronic injections and ingestions were calculated for male and female subjects of six age groups based on the current age-dependent biokinetic model for thorium (Th) recommended by the International Commission on Radiological Protection (ICRP). The results are tabulated in a database. The calculated contents of 228,230,232Th in organs or tissues using their reference concentrations in foodstuffs for the European population are compared with autopsy data. The model prediction of 232Th in whole body for a 50-year-old unexposed person is 22 mBq, 86% of that in skeleton, 9.7% in other soft tissues, 3.4% in liver, 0.7% in kidneys and 0.01% in blood. The modelling predicts lower contents of the natural Th isotopes in whole body, especially in blood compared with measured data for the unexposed public. Modelled 232Th daily urinary excretions are 5 to 10 times less than bio-assay data from the authors' own laboratory.
authors.affiliation: GSF-National Research Center for Environment and Health, Institute of Radiation Protection, Ingolstädter Landstrasse 1, D-85764 Neuherberg, Germany. wli@gsf.de
authors.forename: W B
authors.initials: WB
authors.lastname: Li
authors.forename: W
authors.initials: W
authors.lastname: Wahl
authors.forename: U
authors.initials: U
authors.lastname: Oeh
authors.forename: V
authors.initials: V
authors.lastname: Höllriegl
authors.forename: P
authors.initials: P
authors.lastname: Roth
mesh_terms: D000284:Administration, Oral; D000465:Algorithms; D001681:Biological Assay / Q000379:methods*; D003198:Computer Simulation; D004435:Eating; D004781:Environmental Exposure / Q000032:analysis*; D005858:Germany; D006801:Humans; D038622:Internationality; D007700:Kinetics; D008954:Models, Biological; D011829:Radiation Dosage; D011834:Radiation Monitoring / Q000379:methods*; D011835:Radiation Protection / Q000379:methods; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013910:Thorium / Q000008:administration & dosage* / Q000493:pharmacokinetics*
chemical_list: D013910:Thorium