title: SCO-1, a novel plasmid-mediated class A beta-lactamase with carbenicillinase characteristics from Escherichia coli.
abstract: A novel class A beta-lactamase (SCO-1) encoded by an 80-kb self-transferable plasmid from Escherichia coli is described. The interaction of SCO-1 with beta-lactams was similar to that of the CARB-type enzymes. Also, SCO-1 exhibited a 51% amino acid sequence identity with the RTG subgroup of chromosomal carbenicillinases (RTG-1, CARB-5, and CARB-8).
authors.affiliation: Laboratory of Bacteriology, Institut Pasteur Hellenique, Vas. Sofias 127, Athens 11521, Greece.
authors.forename: C C
authors.initials: CC
authors.lastname: Papagiannitsis
authors.forename: A
authors.initials: A
authors.lastname: Loli
authors.forename: L S
authors.initials: LS
authors.lastname: Tzouvelekis
authors.forename: E
authors.initials: E
authors.lastname: Tzelepi
authors.forename: G
authors.initials: G
authors.lastname: Arlet
authors.forename: V
authors.initials: V
authors.lastname: Miriagou
mesh_terms: D000595:Amino Acid Sequence; D000900:Anti-Bacterial Agents / Q000378:metabolism / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects* / Q000201:enzymology* / Q000235:genetics; D006801:Humans; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D010405:Penicillinase / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D010957:Plasmids; D017422:Sequence Analysis, DNA; D018440:beta-Lactam Resistance; D001618:beta-Lactamases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D047090:beta-Lactams / Q000378:metabolism / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D047090:beta-Lactams; D010405:Penicillinase; D001618:beta-Lactamases