title: Worse renal transplant outcomes observed among Afro-Brazilian patients on prospective registry data of 2461 renal transplants at least 1 year follow-up.
abstract: We present prospective registry data of 2461 (live donor = 1753 and deceased donor = 08) renal transplants performed between 1999 and 2003. All subjects were followed for more than 1 year after transplantation and most were treated with a calcineurin inhibitor and azathioprine. Afro-Brazilian, white, and mixed patients constituted 11% (272), 67.1% (1651), and 14.9% (367) of the population respectively. Mean dialysis time was 42.3 +/- 32.9 months and delayed graft function, occurred in more than 60%. Three-year patient survival rates were 96.3%, 92.8%, and 86.7% for living-related, living-unrelated, and deceased donors, respectively. Corresponding 3-year graft survival rates were 87.3%, 82.1%, and 71.3% and functional graft survival rates were 90.2%, 88.8%, and 81.5%. The poorer transplant outcome observed among Afro-Brazilian patients has been mainly attributed to differences in absorption of cyclosporine, tacrolimus, and mycophenolate mofetil.
authors.affiliation: Hospital do Rim e Hipertensao - Nephrology Division, Universidade Federal de Sao Paulo, Sao Paulo, Brazil. medina@hrim.com.br
authors.forename: J O
authors.initials: JO
authors.lastname: Medina-Pestana
authors.forename: E M
authors.initials: EM
authors.lastname: Sampaio
authors.forename: M L S
authors.initials: ML
authors.lastname: Vaz
authors.forename: P G
authors.initials: PG
authors.lastname: Pinheiro-Machado
authors.forename: H
authors.initials: H
authors.lastname: Tedesco-Silva
mesh_terms: D000328:Adult; D000349:Africa / Q000208:ethnology; D001938:Brazil / Q000453:epidemiology; D002102:Cadaver; D005260:Female; D005500:Follow-Up Studies; D006085:Graft Survival / Q000502:physiology*; D006801:Humans; D016030:Kidney Transplantation / Q000401:mortality / Q000473:pathology / Q000502:physiology* / Q000706:statistics & numerical data; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012042:Registries; D016019:Survival Analysis; D013997:Time Factors; D014019:Tissue Donors; D017211:Treatment Failure; D016896:Treatment Outcome