Acute sirolimus pulmonary toxicity in an infant heart transplant recipient: case report and literature review.
Sirolimus-associated pulmonary disease should be considered in the differential diagnosis of acute respiratory distress syndrome in transplant recipients receiving this drug. It represents a rare, potentially lethal, and yet reversible adverse effect. We report the case an infant who presented with acute respiratory distress 57 days after heart transplantation 3 days after starting sirolimus. The acute presentation and prompt resolution after discontinuation of this drug suggest a direct toxic effect to the lungs. To our knowledge, this is the first published pediatric description of this syndrome after heart transplantation.
Das
Bibhuti B
BB
Division of Cardiology, Department of Pediatrics, University of Louisville, Louisville, Kentucky 40202, USA. bbdas001@gwise.louisville.edu
Shoemaker
Lawrence
L
Subramanian
Sujata
S
Johnsrude
Christopher
C
Recto
Michael
M
Austin
Erle H
EH
D000208:Acute Disease; D002916:Chylothorax / Q000139:chemically induced / Q000000981:diagnostic imaging; D005260:Female; D016027:Heart Transplantation; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D007223:Infant; D017563:Lung Diseases, Interstitial / Q000139:chemically induced / Q000000981:diagnostic imaging; D013902:Radiography, Thoracic; D012131:Respiratory Insufficiency / Q000139:chemically induced* / Q000000981:diagnostic imaging; D020123:Sirolimus / Q000009:adverse effects* / Q000627:therapeutic use
D007166:Immunosuppressive Agents; D020123:Sirolimus