title: Association of caesarean delivery for first birth with placenta praevia and placental abruption in second pregnancy.
abstract: OBJECTIVE
  To quantify the risk of placenta praevia and placental abruption in singleton, second pregnancies after a caesarean delivery of the first pregnancy.
  
  
  METHODS
  Retrospective cohort study.
  
  
  METHODS
  Linked birth and infant mortality database of the USA between 1995 and 2000.
  
  
  METHODS
  A total of 5,146,742 singleton second pregnancies were available for the final analysis after excluding missing information.
  
  
  METHODS
  Multiple logistic regressions were used to describe the relationship between caesarean section at first birth and placenta praevia and placental abruption in second-birth singletons.
  
  
  METHODS
  Placenta praevia and placental abruption.
  
  
  RESULTS
  Placenta praevia was recorded in 4.4 per 1000 second-birth singletons whose first births delivered by caesarean section and 2.7 per 1000 second-birth singletons whose first births delivered vaginally. About 6.8 per 1000 births were complicated with placental abruption in second-birth singletons whose first births delivered by caesarean section and 4.8 per 1000 birth in second-birth singletons whose first births delivered vaginally. The adjusted odds ratio (95% CIs) of previous caesarean section for placenta praevia in following second pregnancies was 1.47 (1.41, 1.52) after controlling for maternal age, race, education, marital status, maternal drinking and smoking during pregnancy, adequacy of prenatal care, and fetal gender. The corresponding figure for placental abruption was 1.40 (1.36, 1.45).
  
  
  CONCLUSIONS
  Caesarean section for first live birth is associated with a 47% increased risk of placenta praevia and 40% increased risk of placental abruption in second pregnancy with a singleton.
authors.affiliation: OMNI Research Group, Clinical Epidemiology Program, Ottawa Health Research Institute, Ontario, Canada. qyang@ohri.ca
authors.forename: Q
authors.initials: Q
authors.lastname: Yang
authors.forename: S W
authors.initials: SW
authors.lastname: Wen
authors.forename: L
authors.initials: L
authors.lastname: Oppenheimer
authors.forename: X K
authors.initials: XK
authors.lastname: Chen
authors.forename: D
authors.initials: D
authors.lastname: Black
authors.forename: J
authors.initials: J
authors.lastname: Gao
authors.forename: M C
authors.initials: MC
authors.lastname: Walker
mesh_terms: D000037:Abruptio Placentae / Q000209:etiology*; D000328:Adult; D017677:Age Distribution; D002585:Cesarean Section / Q000009:adverse effects*; D015331:Cohort Studies; D004522:Educational Status; D005260:Female; D006801:Humans; D017533:Marital Status; D008423:Maternal Age; D010298:Parity; D010923:Placenta Previa / Q000209:etiology*; D011247:Pregnancy; D012044:Regression Analysis; D012189:Retrospective Studies; D012307:Risk Factors; D014481:United States