title: Cocaine-related peripheral vascular occlusive disease treated with iloprost in addition to anticoagulants and antibiotics.
abstract: We describe a case of acute ischemia of the 2nd, 3rd and 4th fingers of the right hand secondary to peripheral vascular occlusive disease induced by repeated intra-arterial cocaine injections. The complete occlusion of the distal arteries resolved following treatment with iloprost, a synthetic stable analogue of prostacyclin PGI2, in addition to anticoagulants and antibiotics.
authors.affiliation: Azienda Ospedale di Legnano, Presidio di Legnano, UO Medicina II, Legnano, Italy.
authors.forename: Antonino
authors.initials: A
authors.lastname: Mazzone
authors.forename: Leopoldo
authors.initials: L
authors.lastname: Giani
authors.forename: Paola
authors.initials: P
authors.lastname: Faggioli
authors.forename: Simona
authors.initials: S
authors.lastname: Pichini
authors.forename: Roberta
authors.initials: R
authors.lastname: Pacifici
mesh_terms: D000208:Acute Disease; D000328:Adult; D019980:Amoxicillin-Potassium Clavulanate Combination / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000925:Anticoagulants / Q000627:therapeutic use; D001157:Arterial Occlusive Diseases / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D019970:Cocaine-Related Disorders / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D004359:Drug Therapy, Combination; D006225:Hand / Q000098:blood supply* / Q000473:pathology; D006801:Humans; D016285:Iloprost / Q000627:therapeutic use*; D007511:Ischemia / Q000139:chemically induced / Q000188:drug therapy / Q000473:pathology; D008297:Male; D017762:Nadroparin / Q000627:therapeutic use; D016491:Peripheral Vascular Diseases / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D016896:Treatment Outcome; D014665:Vasodilator Agents / Q000627:therapeutic use*
chemical_list: D000900:Anti-Bacterial Agents; D000925:Anticoagulants; D017762:Nadroparin; D014665:Vasodilator Agents; D019980:Amoxicillin-Potassium Clavulanate Combination; D016285:Iloprost