Design and functional activity of phosphopeptides with potential immunomodulating capacity, based on the sequence of Grb2-associated binder 1.
A cell membrane permeable phosphopeptide corresponding to the SHP-2 binding motif of Grb2-associated binder 1 (Gab1) interferes with the Gab1 adaptor-dependent functions and modulates B cell receptor-triggered intracellular signaling in B cell tumors.
Kertesz
Akos
A
Department of Immunology, Eotvos Lorand University, Pazmany Peter setany 1/c, 1117 Budapest, Hungary.
Takacs
Balazs
B
Varadi
Gyorgyi
G
Toth
Gabor K
GK
Sarmay
Gabriella
G
D048868:Adaptor Proteins, Signal Transducing / Q000138:chemical synthesis* / Q000235:genetics / Q000502:physiology*; D020816:Amino Acid Motifs; D002051:Burkitt Lymphoma / Q000737:chemistry / Q000276:immunology / Q000378:metabolism; D045744:Cell Line, Tumor; D015195:Drug Design; D005822:Genetic Vectors; D006801:Humans; D007155:Immunologic Factors / Q000138:chemical synthesis* / Q000235:genetics / Q000502:physiology*; D047908:Intracellular Signaling Peptides and Proteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology; D010748:Phosphopeptides / Q000138:chemical synthesis* / Q000235:genetics / Q000502:physiology*; D011485:Protein Binding; D015202:Protein Engineering; D054592:Protein Tyrosine Phosphatase, Non-Receptor Type 11; D017027:Protein Tyrosine Phosphatases / Q000737:chemistry / Q000235:genetics / Q000502:physiology
D048868:Adaptor Proteins, Signal Transducing; C098587:GAB1 protein, human; D007155:Immunologic Factors; D047908:Intracellular Signaling Peptides and Proteins; D010748:Phosphopeptides; C516724:PTPN11 protein, human; D054592:Protein Tyrosine Phosphatase, Non-Receptor Type 11; D017027:Protein Tyrosine Phosphatases