title: Migraine and coronary heart disease mortality: a prospective cohort study.
abstract: A recent population-based prospective study reported that in women, migraine with aura (MA), but not migraine without aura (MoA), was associated with increased risk of coronary heart disease events (CHD). We sought to confirm this association in an Australian population-based cohort of older men and women (n = 2331, aged 49-97 years). We defined MA and MoA from face-to-face interview using International Headache Society criteria. Over a mean 6-year follow-up, 30 women (2.8%) and 30 men (4.4%) without any prior CHD history died from CHD-related causes. In women, a history of MA was associated with a non-significant twofold higher risk of CHD death (age-adjusted relative risk 2.2, 95% confidence interval 0.8, 5.8, P = 0.11), which remained similar after adjustment for cardiovascular risk factors. There were no CHD deaths in men with a history of migraine. Our findings support reports that in women, MA, but not MoA, may be associated with increased risk of CHD.
authors.affiliation: Centre for Vision Research, Department of Ophthalmology (Westmead Hospital), the Westmead Millennium Institute, University of Sydney, Sydney, Australia.
authors.forename: G
authors.initials: G
authors.lastname: Liew
authors.forename: J J
authors.initials: JJ
authors.lastname: Wang
authors.forename: P
authors.initials: P
authors.lastname: Mitchell
mesh_terms: D017677:Age Distribution; D000368:Aged; D001315:Australia / Q000453:epidemiology; D015331:Cohort Studies; D015897:Comorbidity; D003327:Coronary Disease / Q000401:mortality*; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008881:Migraine Disorders / Q000401:mortality*; D011446:Prospective Studies; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D017678:Sex Distribution; D016019:Survival Analysis; D015996:Survival Rate