title: Action of a silk fabric treated with AEGIS in children with atopic dermatitis: a 3-month trial.
abstract: Irritation of the skin of patients with atopic dermatitis by contact with rough fibres of synthetic or woollen clothes is well known. Therefore, it has been recommended that patients should wear cotton clothes. However, cotton also consists of rough fibres able to irritate the skin, whereas silk is characterized by smooth fibres without irritating potential. The aim of our study was to evaluate the clinical effect of Dermasilk- a special silk fabric (sericin-free silk treated with AEGIS AEM5772/5 which has antibacterial properties) - in children with atopic dermatitis. A total of 22 children with mild-to-moderate atopic dermatitis were recruited for a study period of 3 months. All of them received three different tube-fabrics - Dermasilk, sericin-free silk fabric without AEGIS AEM 5772/5 and cotton, covering the cubital region. Patients were advised to wear the Dermasilk fabric all day long during the whole study period on one arm, whereas the sericin-free AEGIS-free silk tube had to be used during the first 2 wk only on the other arm followed by the use of the cotton tube for the rest of the study period. Evaluation of the local SCORAD score was carried out at the beginning of the study, after 2, 4, 8 and 12 wk. A significant reduction of the local SCORAD index of the Dermasilk covered arm was observed after 4, 8 and 12 wk in comparison with the cotton-covered arm score [median (quartile 1-quartile 3)] 6.5 (5-8) vs. 8 (7-9), p < 0.002; 6 (5.25-7.75) vs. 8 (7-9), p < 0.0001; and 6 (5-6) vs. 8 (7.25-10), p < 0.0001. The use of Dermasilk has a significant beneficial effect in atopic dermatitis because of the non-irritating properties of silk as well as the antibacterial capacity of AEGIS AEM 5772/5.
authors.affiliation: Paediatric Ambulatory Care Unit, Department of Paediatrics, Medical University Vienna, Vienna, Austria. dieter.koller@meduniwien.ac.at
authors.forename: D Y
authors.initials: DY
authors.lastname: Koller
authors.forename: G
authors.initials: G
authors.lastname: Halmerbauer
authors.forename: A
authors.initials: A
authors.lastname: Böck
authors.forename: G
authors.initials: G
authors.lastname: Engstler
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D032561:Cotton Fiber; D003876:Dermatitis, Atopic / Q000628:therapy*; D005260:Female; D006801:Humans; D008297:Male; D047011:Silk / Q000627:therapeutic use*
chemical_list: D000900:Anti-Bacterial Agents; D047011:Silk