[Association between vascular endothelial growth factor gene 936 T/C polymorphism and colorectal cancer together with anastomotic leakage].
OBJECTIVE
To investigate the association between VEGF gene 936 T/C polymorphism and colorectal cancer together with anastomotic leakage.


METHODS
Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to detect the VEGF 936 T/C genotypes in colorectal cancer patients and healthy controls.


RESULTS
There was no significant difference in the frequency of VEGF 936 C/C genotype or C allele between colorectal cancer patients and healthy controls (P > 0.05). The C/C genotype or C allele in colorectal cancer patients with anastomotic leakage was less frequently found than in the group without anastomotic leakage (P < 0.05).


CONCLUSIONS
VEGF 936 C/C genotype or C allele is not related to the development of colorectal cancer, but they can reduce the risk of anastomotic leakage after surgery in colorectal cancer patients.
Wu
Guo-Yang
GY
Department of General Surgery, Zhongshan Hospital, Xiamen University, Amoy, China.
Wang
Xiao-Min
XM
Keese
Michael
M
Hasenberg
Till
T
Sturm
Jörg W
JW
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D015179:Colorectal Neoplasms / Q000235:genetics* / Q000601:surgery; D016154:Digestive System Fistula / Q000209:etiology / Q000235:genetics*; D016228:Endothelial Growth Factors / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D011183:Postoperative Complications / Q000209:etiology; D054047:Surgical Stomas / Q000009:adverse effects
D016228:Endothelial Growth Factors