title: Resting state cortical connectivity reflected in EEG coherence in individuals with autism.
abstract: BACKGROUND
  Theoretical conceptions of autism spectrum disorder (ASD) and experimental studies of cerebral blood flow suggest abnormalities in connections among distributed neural systems in ASD.
  
  
  METHODS
  Functional connectivity was assessed with electroencephalographic coherence between pairs of electrodes in a high-density electrode array in narrow frequency bands among 18 adults with ASD and 18 control adults in an eyes closed resting state.
  
  
  RESULTS
  In the theta (3-6 Hz) frequency range, locally elevated coherence was evident for the ASD group, especially within left hemisphere frontal and temporal regions. In the lower alpha range (8-10 Hz), globally reduced coherence was evident for the ASD group within frontal regions and between frontal and all other scalp regions. The ASD group exhibited significantly greater relative power between 3 and 6 Hz and 13-17 Hz and significantly less relative power between 9 and 10 Hz.
  
  
  CONCLUSIONS
  Robust patterns of over- and under-connectivity are apparent at distinct spatial and temporal scales in ASD subjects in the eyes closed resting state.
authors.affiliation: University of Washington Autism Center, Seattle, Washington 98195, USA. mmurias@u.washington.edu
authors.forename: Michael
authors.initials: M
authors.lastname: Murias
authors.forename: Sara J
authors.initials: SJ
authors.lastname: Webb
authors.forename: Jessica
authors.initials: J
authors.lastname: Greenson
authors.forename: Geraldine
authors.initials: G
authors.lastname: Dawson
mesh_terms: D000293:Adolescent; D000328:Adult; D001143:Arousal / Q000502:physiology*; D001321:Autistic Disorder / Q000503:physiopathology*; D001931:Brain Mapping; D016022:Case-Control Studies; D002540:Cerebral Cortex / Q000502:physiology*; D003344:Cortical Synchronization; D004569:Electroencephalography; D006801:Humans; D008297:Male; D009434:Neural Pathways / Q000502:physiology; D012016:Reference Values