[Effect of ecopathogenic environmental factors on the system of antioxidant defense in different parts of the rat brain].
Influence ofecopathogenic environmental (radiation-chemical) factors on activities of superoxiddismutase, catalase and total antioxidative activity (TAA) has been investigated in morphologically and functionally different parts of rat brain. It has been found that reaction of cells in brain cortex, subcortical structures and cerebellum to these factors in all cases is revealed through the antioxidant enzyme activities decrease in all studied brain structures but in various degrees. In brain cortex, which is characterized by higher metabolic level, functional complexity and specialization, the higher level of antioxidation defense is marked both in normal state and under the action of negative factors, that allows to maintain the prooxidation-antioxidation balance. Subcortical structures were more sensitive to the heavy metal impact. Compared to the action of single factors at chronic combined influence of radiation and heavy metals on the separate antioxidative enzymes a summation effect can be observed and at aforesaid joint impact on multi-component system of antioxidation defense a partial mutual evening-out of effects of radiation and chemical agents can be marked.
Severynovs'ka
O V
OV
Hryhorova
M O
MO
Zaĭchenko
O Iu
OIu
Rybal'chenko
V K
VK
D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D001921:Brain / Q000187:drug effects / Q000201:enzymology / Q000528:radiation effects; D002374:Catalase / Q000378:metabolism; D011829:Radiation Dosage; D011839:Radiation, Ionizing; D051381:Rats; D013482:Superoxide Dismutase / Q000378:metabolism; D014874:Water Pollutants, Chemical / Q000633:toxicity*
D000975:Antioxidants; D014874:Water Pollutants, Chemical; D002374:Catalase; D013482:Superoxide Dismutase