[Investigation of the effect of doxorubicin on the intracellular signaling system].
The effect of the antitumor antibiotic doxorubicin on the mechanisms of intracellular signal transduction in the region of free water dispersion has been investigated by the EHF-dielectrometry method. It was shown that the drug whose main target is nuclear DNA has a rather strong influence on free cells of the nucleus, the functions of catecholamine receptors, and the complex of adenylate cyclase with the cytoskeleton. The effect of the drug has significant individual and species differences. Variants of tests for individual selection of doses in the therapeutic practice are suggested.
Shchegoleva
T Iu
TIu
Nikitina
N S
NS
Ruzhel'nik
E A
EA
D000262:Adenylyl Cyclases / Q000378:metabolism; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology*; D001792:Blood Platelets / Q000166:cytology / Q000378:metabolism*; D003593:Cytoplasm / Q000378:metabolism; D003599:Cytoskeleton / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004317:Doxorubicin / Q000494:pharmacology*; D004789:Enzyme Activation / Q000187:drug effects; D004912:Erythrocytes / Q000166:cytology / Q000378:metabolism*; D006801:Humans; D051381:Rats; D015398:Signal Transduction / Q000187:drug effects*; D013045:Species Specificity
D000903:Antibiotics, Antineoplastic; D004317:Doxorubicin; D000262:Adenylyl Cyclases