title: Guttiferones K and L, antiproliferative compounds of Rheedia calcicola from the Madagascar rain forest.
abstract: Bioassay-guided fractionation of the ethanol extract obtained from the fruits of Rheedia calcicola led to the isolation of two new guttiferone analogues, guttiferones K (1) and L (16-hydroxyguttiferone K) (2). The structures of 1 and 2 were established on the basis of extensive interpretation of one- and two-dimensional NMR spectroscopic data. Both compounds were tested for their antiproliferative activity against the A2780 human ovarian cancer cell line.
authors.affiliation: Department of Chemistry, M/C 0212, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA.
authors.forename: Shugeng
authors.initials: S
authors.lastname: Cao
authors.forename: Peggy J
authors.initials: PJ
authors.lastname: Brodie
authors.forename: James S
authors.initials: JS
authors.lastname: Miller
authors.forename: Fidy
authors.initials: F
authors.lastname: Ratovoson
authors.forename: Chris
authors.initials: C
authors.lastname: Birkinshaw
authors.forename: Sennen
authors.initials: S
authors.lastname: Randrianasolo
authors.forename: Etienne
authors.initials: E
authors.lastname: Rakotobe
authors.forename: Vincent E
authors.initials: VE
authors.lastname: Rasamison
authors.forename: David G I
authors.initials: DG
authors.lastname: Kingston
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001577:Benzophenones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D028084:Clusiaceae / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D005260:Female; D005638:Fruit / Q000737:chemistry; D006801:Humans; D008270:Madagascar; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010946:Plants, Medicinal / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D001577:Benzophenones; C519762:guttiferone K; C519763:guttiferone L