title: Recent concepts in the management of bowel problems after spinal cord injury.
abstract: Bowel problems after SCI can be debilitating. Colonic inertia as a result of decreased parasympathetic (S2-4) stimulation of the left colon and rectosigmoid seems to be the principal abnormality accounting for DWE. The conventional measures used for decades have poor results in many people. Neostigmine, an anticholinesterase inhibitor, appears to be a more physiological agent for these individuals. The combination of neostigmine + glycopyrrolate infusion has shown encouraging results after intravenous administration and studies are under way to assess the efficacy of neostigmine by other routes.
authors.affiliation: Internal Mediciney Programs Spinal Cord Center of Excellence, USA.
authors.forename: A K
authors.initials: AK
authors.lastname: Singal
authors.forename: A S
authors.initials: AS
authors.lastname: Rosman
authors.forename: W A
authors.initials: WA
authors.lastname: Bauman
authors.forename: M A
authors.initials: MA
authors.lastname: Korsten
mesh_terms: D003106:Colon / Q000187:drug effects / Q000503:physiopathology; D003109:Colonic Diseases, Functional / Q000188:drug therapy* / Q000209:etiology; D003248:Constipation / Q000188:drug therapy* / Q000209:etiology; D004359:Drug Therapy, Combination; D006024:Glycopyrrolate / Q000627:therapeutic use; D006801:Humans; D009388:Neostigmine / Q000627:therapeutic use; D013119:Spinal Cord Injuries / Q000150:complications*
chemical_list: D009388:Neostigmine; D006024:Glycopyrrolate