title: Fiber bundle estimation and parameterization.
abstract: Individual white matter fibers cannot be resolved by current magnetic resonance (MR) technology. Many fibers of a fiber bundle will pass through an individual volume element (voxel). Individual visualized fiber tracts are thus the result of interpolation on a relatively coarse voxel grid, and an infinite number of them may be generated in a given volume by interpolation. This paper aims at creating a level set representation of a fiber bundle to describe this apparent continuum of fibers. It further introduces a coordinate system warped to the fiber bundle geometry, allowing for the definition of geometrically meaningful fiber bundle measures.
authors.affiliation: Psychiatry Neuroimaging Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston MA, USA. marc@bwh.harvard.edu
authors.forename: Marc
authors.initials: M
authors.lastname: Niethammer
authors.forename: Sylvain
authors.initials: S
authors.lastname: Bouix
authors.forename: Carl-Fredrik
authors.initials: CF
authors.lastname: Westin
authors.forename: Martha E
authors.initials: ME
authors.lastname: Shenton
mesh_terms: D000465:Algorithms; D001185:Artificial Intelligence; D001921:Brain / Q000033:anatomy & histology*; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D009413:Nerve Fibers, Myelinated / Q000648:ultrastructure*; D009434:Neural Pathways / Q000033:anatomy & histology*; D010363:Pattern Recognition, Automated / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity