title: Cortical biochemistry in MCI and Alzheimer disease: lack of correlation with clinical diagnosis.
abstract: OBJECTIVE
  Mild cognitive impairment, hypothesized to be prodromal Alzheimer disease (AD), shows abundant senile plaques and neurofibrillary tangles, but its biochemical correlates remain undefined.
  
  
  METHODS
  Biochemical profiles of Abeta, tau, alpha-synuclein, and oxidative pathologies were characterized in middle frontal gyrus, inferior parietal cortex, and entorhinal cortex in postmortem frozen brains from subjects diagnosed antemortem with no cognitive impairment, mild cognitive impairment, or AD.
  
  
  RESULTS
  Insoluble Abeta and tau, as well as tissue isoprostanes, from each brain region analyzed did not correlate with the clinical diagnosis proximate to death, but insoluble Abeta and 8,12-iso-iPF(2alpha)-VI levels from gray matter of all brain regions correlated strongly with the burden of AD pathology, whereas insoluble tau did not.
  
  
  CONCLUSIONS
  The biochemical alterations in cortical tau, Abeta, and isoprostane do not reflect the onset of clinical dementia.
authors.affiliation: Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 422 Curie Blvd., 605B Stellar-Chance Building, Philadelphia, PA 19104, USA. formanm@mail.med.upenn.edu
authors.forename: M S
authors.initials: MS
authors.lastname: Forman
authors.forename: E J
authors.initials: EJ
authors.lastname: Mufson
authors.forename: S
authors.initials: S
authors.lastname: Leurgans
authors.forename: D
authors.initials: D
authors.lastname: Pratico
authors.forename: S
authors.initials: S
authors.lastname: Joyce
authors.forename: S
authors.initials: S
authors.lastname: Leight
authors.forename: V M-Y
authors.initials: VM
authors.lastname: Lee
authors.forename: J Q
authors.initials: JQ
authors.lastname: Trojanowski
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000378:metabolism / Q000473:pathology*; D016229:Amyloid beta-Peptides / Q000378:metabolism; D000704:Analysis of Variance; D001923:Brain Chemistry; D002540:Cerebral Cortex / Q000378:metabolism*; D003072:Cognition Disorders / Q000378:metabolism / Q000473:pathology*; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods; D006801:Humans; D007118:Immunoassay / Q000379:methods; D028421:Isoprostanes / Q000378:metabolism; D008297:Male; D016875:tau Proteins / Q000378:metabolism
chemical_list: D016229:Amyloid beta-Peptides; D028421:Isoprostanes; D016875:tau Proteins