The effect of squamous and/or glandular differentiation on recurrence, progression and survival in urothelial carcinoma of bladder.
BACKGROUND
The effects of squamous and/or glandular differentiation in urothelial carcinoma of bladder on recurrence, progression and survival rate were evaluated in this study.


METHODS
Between 1998 and 2003, a total of 223 patients who had been treated with transurethral resection for bladder cancers were evaluated. The patients were divided into two groups as; Group I: tumor patients with squamous and/or glandular differentiation, Group II: patients without these findings.


RESULTS
Histologically 189 (84.7%) were conventional urothelial carcinoma and 34 (15.2%) were tumors with squamous and/or glandular differentiation. The mean age of the patients was 64.4 +/- 12.7 (range 36-81) years. Survival rates within a period of 46.23 +/- 14.8 (12-67) months were 76.47% for Group I and 89.94% for Group II (P = 0.027). The stage distribution as pTa, pT1, and >/=pT2 was 2 (5.9%), 18 (52.9%), and 14 (41.2%) in Group I and 101 (53.4%), 51 (27%) and 37 (19.6%) in group II, respectively (P = 0.001). There was a statistically significant tendency towards higher stage at presentation in Group I and the grade distribution was significantly higher in Group I than Group II (P < 0.001).


CONCLUSIONS
High recurrence rates and poor prognosis of these patients should be kept in mind in the follow-up period. In this respect, these patients should be followed up closely.
Erdemir
Fikret
F
Yeşilirmak M. Bosna C. 3. Sok., No:7, Mollaoğullari Apt. K:2, D;3, Merkez, Tokat, 60100, Turkey. fikreterdemir@mynet.com
Tunc
Murat
M
Ozcan
Faruk
F
Parlaktas
Bekir S
BS
Uluocak
Nihat
N
Kilicaslan
Isin
I
Gokce
Ozgur
O
D000368:Aged; D000369:Aged, 80 and over; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology*; D001749:Urinary Bladder Neoplasms / Q000401:mortality / Q000473:pathology*; D019459:Urothelium / Q000473:pathology