[Carminerin contributes to chondrocyte calcification during pathological endochondral ossification].
Endochondral ossification is an essential process not only for physiological skeletal development and growth, but also for pathological disorders such as osteophyte formation in osteoarthritic joints and ectopic ossification with ageing. We recently identified a novel cartilage-specific molecule carminerin. Although the carminerin-deficient mice developed and grew normally, pathological endochondral ossification were suppressed. We conclude that carminerin contributes to chondrocyte calcification during pathological endochondral ossification without affecting physiological skeletal conditions, suggesting that this molecule could be a therapeutic target for these disorders.
Yamada
Takashi
T
The University of Tokyo, Faculty of Medicine, Department of Sensory & Motor System Medicine.
Koshizuka
Yu
Y
Kawaguchi
Hiroshi
H
D000818:Animals; D002478:Cells, Cultured; D019902:Chondrocytes / Q000473:pathology*; D003001:Cloning, Molecular; D050659:Core Binding Factor Alpha 1 Subunit / Q000502:physiology; D015891:Cystatins / Q000037:antagonists & inhibitors* / Q000502:physiology*; D006609:High Mobility Group Proteins / Q000502:physiology; D006801:Humans; D051379:Mice; D009999:Ossification, Heterotopic / Q000188:drug therapy* / Q000235:genetics*; D010727:Phosphoric Diester Hydrolases / Q000502:physiology; D011755:Pyrophosphatases / Q000502:physiology; D055758:SOX9 Transcription Factor; D014157:Transcription Factors / Q000502:physiology
D050659:Core Binding Factor Alpha 1 Subunit; C480168:Cst10 protein, mouse; D015891:Cystatins; D006609:High Mobility Group Proteins; C493716:Runx2 protein, mouse; D055758:SOX9 Transcription Factor; C527932:SOX9 protein, human; C527933:Sox9 protein, mouse; D014157:Transcription Factors; D010727:Phosphoric Diester Hydrolases; C065962:ectonucleotide pyrophosphatase phosphodiesterase 1; D011755:Pyrophosphatases