title: Production and biological activity of laidlomycin, anti-MRSA/VRE antibiotic from Streptomyces sp. CS684.
abstract: Culture broth of a streptomycete isolate, Streptomyces sp. CS684 showed antibacterial activity on methicillin resistant Staphylococcus aureus (MRSA) and vancomycin resistant enterococci (VRE). Among purified substances from the organism, CSU-1, which is active against MRSA and VRE, is a C37H62O12Na (M+, 721.3875), and identified as laidlomycin. The anti-MRSA and anti-VRE activity of CSU-1 was stronger than oxacillin and vancomycin. Phylogenetic analysis showed that strain CS684 is very similar to Streptomyces ardus NRRL 2817T, whereas the ability of Streptomyces sp. CS684 to produce laidlomycin was shown to be unique.
authors.affiliation: Department of Pharmacy, Chosun University, Gwangju 501-759, Republic of Korea.
authors.forename: Jin Cheol
authors.initials: JC
authors.lastname: Yoo
authors.forename: Jun Ho
authors.initials: JH
authors.lastname: Kim
authors.forename: Jung Wan
authors.initials: JW
authors.lastname: Ha
authors.forename: Nae Soo
authors.initials: NS
authors.lastname: Park
authors.forename: Jae Kyung
authors.initials: JK
authors.lastname: Sohng
authors.forename: June Woo
authors.initials: JW
authors.lastname: Lee
authors.forename: Seong Chan
authors.initials: SC
authors.lastname: Park
authors.forename: Mi Sun
authors.initials: MS
authors.lastname: Kim
authors.forename: Chi Nam
authors.initials: CN
authors.lastname: Seong
mesh_terms: D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000494:pharmacology; D024881:Drug Resistance, Bacterial; D007723:Korea; D016106:Methicillin Resistance; D008985:Monensin / Q000031:analogs & derivatives* / Q000096:biosynthesis / Q000494:pharmacology; D010802:Phylogeny; D012988:Soil Microbiology; D013211:Staphylococcus aureus / Q000187:drug effects*; D013302:Streptomyces / Q000145:classification / Q000378:metabolism*; D020713:Vancomycin Resistance
chemical_list: D000900:Anti-Bacterial Agents; D008985:Monensin; C010208:laidlomycin