title: Design, synthesis, and evaluation of the antiproliferative activity of a series of novel fused xanthenone aminoderivatives in human breast cancer cells.
abstract: Derivatives of two novel, structurally related heterocyclic ring systems, xantheno[3,4-d]imidazole and chromeno[4,3,2-c,d]imidazo[4,5-f]indazole, bearing aminoalkyl side chains, have been synthesized, and their antiproliferative activity has been studied against the aggressive human breast MDA-MB-231 cell line. The pyrazole-fused analogue 27a possesses a pronounced antiproliferative effect on the tested cell line, evident at 1 muM, and achieves an IC50 of 6.5 microM.
authors.affiliation: Department of Pharmacy, Division of Pharmaceutical Chemistry, University of Athens, Panepistimiopolis-Zografou, Athens 15771, Greece.
authors.forename: Vasiliki
authors.initials: V
authors.lastname: Giannouli
authors.forename: Ioannis K
authors.initials: IK
authors.lastname: Kostakis
authors.forename: Nicole
authors.initials: N
authors.lastname: Pouli
authors.forename: Panagiotis
authors.initials: P
authors.lastname: Marakos
authors.forename: Olga Ch
authors.initials: OCh
authors.lastname: Kousidou
authors.forename: George N
authors.initials: GN
authors.lastname: Tzanakakis
authors.forename: Nikos K
authors.initials: NK
authors.lastname: Karamanos
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001578:Benzopyrans / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001943:Breast Neoplasms; D015195:Drug Design; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006576:Heterocyclic Compounds, 4 or More Rings / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D007093:Imidazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D014966:Xanthenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D001578:Benzopyrans; D006576:Heterocyclic Compounds, 4 or More Rings; D007093:Imidazoles; D014966:Xanthenes