title: Allergy evaluation after emergency treatment: anaphylaxis to the over-the-counter medication clobutinol.
abstract: Anaphylaxis is traditionally diagnosed and treated as an acute emergency but should be always followed by a search for specific triggers, resulting in avoidance strategies. This case report highlights the relevance of a detailed evaluation after anaphylaxis for diagnosis of a rare but potentially life-threatening allergy. Considering the high frequency of clobutinol application, IgE-mediated allergic hypersensitivity seems extremely rare and has to be distinguished from infection-associated urticaria and angioedema as well as non-specific summation effects. Accidental re-exposure has to be strictly avoided and therefore after identification of clobutinol as the anaphylaxis trigger, the patient received detailed allergy documents including international non-proprietary and trade names of the culprit drug.
authors.affiliation: Department of Dermatology, Venerology and Allergology, University of Würzburg, Josef Schneider Strasse 2, D-97080 Würzburg, Germany.
authors.forename: Cornelia S
authors.initials: CS
authors.lastname: Seitz
authors.forename: Eva-B
authors.initials: EB
authors.lastname: Bröcker
authors.forename: Axel
authors.initials: A
authors.lastname: Trautmann
mesh_terms: D000328:Adult; D000605:Amino Alcohols / Q000009:adverse effects*; D000707:Anaphylaxis / Q000139:chemically induced / Q000175:diagnosis* / Q000517:prevention & control; D000996:Antitussive Agents / Q000009:adverse effects*; D004342:Drug Hypersensitivity / Q000175:diagnosis* / Q000209:etiology / Q000517:prevention & control; D004630:Emergencies; D006801:Humans; D008297:Male; D004366:Nonprescription Drugs / Q000009:adverse effects*
chemical_list: D000605:Amino Alcohols; D000996:Antitussive Agents; D004366:Nonprescription Drugs; C017135:clobutinol