Production and biological activity of laidlomycin, anti-MRSA/VRE antibiotic from Streptomyces sp. CS684.
Culture broth of a streptomycete isolate, Streptomyces sp. CS684 showed antibacterial activity on methicillin resistant Staphylococcus aureus (MRSA) and vancomycin resistant enterococci (VRE). Among purified substances from the organism, CSU-1, which is active against MRSA and VRE, is a C37H62O12Na (M+, 721.3875), and identified as laidlomycin. The anti-MRSA and anti-VRE activity of CSU-1 was stronger than oxacillin and vancomycin. Phylogenetic analysis showed that strain CS684 is very similar to Streptomyces ardus NRRL 2817T, whereas the ability of Streptomyces sp. CS684 to produce laidlomycin was shown to be unique.
Yoo
Jin Cheol
JC
Department of Pharmacy, Chosun University, Gwangju 501-759, Republic of Korea.
Kim
Jun Ho
JH
Ha
Jung Wan
JW
Park
Nae Soo
NS
Sohng
Jae Kyung
JK
Lee
June Woo
JW
Park
Seong Chan
SC
Kim
Mi Sun
MS
Seong
Chi Nam
CN
D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000494:pharmacology; D024881:Drug Resistance, Bacterial; D007723:Korea; D016106:Methicillin Resistance; D008985:Monensin / Q000031:analogs & derivatives* / Q000096:biosynthesis / Q000494:pharmacology; D010802:Phylogeny; D012988:Soil Microbiology; D013211:Staphylococcus aureus / Q000187:drug effects*; D013302:Streptomyces / Q000145:classification / Q000378:metabolism*; D020713:Vancomycin Resistance
D000900:Anti-Bacterial Agents; D008985:Monensin; C010208:laidlomycin