[Relationship between transforming growth factor-alpha gene polymorphism and non-syndromic cleft lip with cleft palate].
OBJECTIVE
To study the association of TGF-alpha gene polymorphism and non-syndromic cleft lip with cleft palate in Shandong province.


METHODS
Polymerase chain reaction combined with restrict enzyme digestion was used to detect the target gene variation in 98 patients with non-syndromic cleft lip with cleft palate and 101 healthy controls.


RESULTS
The C2 allele frequency in patients with non-syndromic cleft lip with cleft palate was significantly higher than that in healthy controls. The genotype frequency in patients with positive family history was significantly higher than that without positive family history.


CONCLUSIONS
TGF-alpha gene polymorphism is closely associated with non-syndromic cleft lip with cleft palate in Shandong, especially in patients with positive family history.
Yuan
Kui-Feng
KF
Dept. of Oral and Maxillofacial Surgery, The Second Hospital of Shandong University, Jinan 250033, China.
Lai
Qing-Guo
QG
Li
De-Ren
DR
Yang
Zhong-Jun
ZJ
Zhou
Xiao-Hong
XH
D002971:Cleft Lip; D002972:Cleft Palate; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D016211:Transforming Growth Factor alpha
D016211:Transforming Growth Factor alpha