title: A patient with leg weakness.
abstract: The present case was typical in many respects for neuroinvasive WNV infection. The differential diagnosis considered was appropriately comprehensive. The present case also reminds us that little or no abnormalities will be seen on imaging in many cases, and that initial serology may be negative and should be repeated beyond the acute phase ante- or postmortem. Fortunately, specific antibodies are also now available for identification of viral proteins in tissue although sensitivity of the latter may be affected by the stage of infection and sampling of areas bearing a higher viral load. West Nile Virus, along with other emerging infections, serves notice of the health care implications of humanity's globalization of ecosystems.
authors.forename: Julia
authors.initials: J
authors.lastname: Keith
authors.forename: Michael
authors.initials: M
authors.lastname: Nicolle
authors.forename: Elena
authors.initials: E
authors.lastname: Tugaleva
authors.forename: Michael
authors.initials: M
authors.lastname: Shkrum
authors.forename: Juan
authors.initials: J
authors.lastname: Bilbao
authors.forename: Robert
authors.initials: R
authors.lastname: Hammond
mesh_terms: D000368:Aged; D000914:Antibodies, Viral / Q000032:analysis / Q000097:blood / Q000276:immunology; D000956:Antigens, Viral / Q000276:immunology; D001921:Brain / Q000473:pathology / Q000821:virology; D003937:Diagnosis, Differential; D018450:Disease Progression; D017809:Fatal Outcome; D005260:Female; D005334:Fever / Q000209:etiology; D006801:Humans; D016867:Immunocompromised Host / Q000276:immunology; D007866:Leg / Q000503:physiopathology*; D018908:Muscle Weakness / Q000503:physiopathology / Q000821:virology*; D009420:Nervous System / Q000276:immunology / Q000503:physiopathology / Q000821:virology*; D009474:Neurons / Q000473:pathology / Q000821:virology; D020335:Paraparesis / Q000503:physiopathology / Q000821:virology*; D012698:Serologic Tests / Q000592:standards; D014901:West Nile Fever / Q000097:blood / Q000175:diagnosis* / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral; D000956:Antigens, Viral