title: Relationship between smoking, white blood cell count and metabolic syndrome in Japanese women.
abstract: We found that cigarette smoking increased white blood cell count, and individuals which increased white blood cell count more likely to have metabolic syndrome in Japanese men. We investigated whether similar relationship can be observed also in women. We analyzed the data from 16,383 Japanese women who underwent general health screening. Age-adjusted logistic regression analysis showed that current smoking was positively associated with a highest white blood cell count quartile with an odds ratio of 2.40 (95% CI: 2.16-2.68, P<0.0001). The white blood cell count showed a graded association with metabolic syndrome. On the other hand, the association between current smoking and metabolic syndrome was no longer significant after subdividing the individuals into groups according to the white blood cell quartile. These data collectively suggested that the association between current smoking and metabolic syndrome is heavily confounded by certain factors that increase the circulating white blood cell count in Japanese women, as in men.
authors.affiliation: Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Hongo 7-3-1, Tokyo, Japan. nobuishizka-tky@umin.ac.jp
authors.forename: Nobukazu
authors.initials: N
authors.lastname: Ishizaka
authors.forename: Yuko
authors.initials: Y
authors.lastname: Ishizaka
authors.forename: Ei-Ichi
authors.initials: E
authors.lastname: Toda
authors.forename: Ryozo
authors.initials: R
authors.lastname: Nagai
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Koike
authors.forename: Hideki
authors.initials: H
authors.lastname: Hashimoto
authors.forename: Minoru
authors.initials: M
authors.lastname: Yamakado
mesh_terms: D000328:Adult; D001794:Blood Pressure; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000378:metabolism; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D007564:Japan; D007958:Leukocyte Count; D008055:Lipids / Q000097:blood; D024821:Metabolic Syndrome / Q000097:blood* / Q000150:complications*; D008875:Middle Aged; D010976:Platelet Count; D012907:Smoking / Q000009:adverse effects / Q000097:blood*
chemical_list: D002097:C-Reactive Protein; D006442:Glycated Hemoglobin; D006454:Hemoglobins; D008055:Lipids