[Estimation of clinical reliability and diagnostic usefulness of human fatty acid-binding protein in acute coronary syndromes].
Human fatty acid-binding protein (h-FABP) is an early marker of myocardial ischemia. It has high sensitivity and specificity comparing with conventional biomarkers such as troponin or creatine kinase.


METHODS
The examinated group consisted of 83 patients, 31 (37,3%) women and 52 (62,7%) men. Every patient with chest pain typical for acute coronary syndrome was diagnosed from May until September 2005 in the emergency room of the Clinic of Cardiology. Every blood sample was tested for h-FABP with Cardio Detect med. test.


RESULTS
Sensitivity for h-FABP at STEMI patients was: during first 3h - 95, 83%, 3-6h - 100%, 6-12h - 100%, over 12h - 100%. Sensitivity for h-FABP at NSTEMI patients was: 100%, 100%, 83% and 71,4%.


CONCLUSIONS
H-FABP is an early diagnostic marker. Its sensitivity and specificity during first 6h from the beginning of chest pain comparing to troponin T and CK-MB is very high. Fast results given by measurements of h-FABP allow to make an early decision about further invasive treatment of patients.
Rembek
Magdalena
M
Medical University of Lodz, Clinical Hospital No. 3, Poland. rembek@bg.am.lodz.pl
Goch
Aleksander
A
Chizyński
Krzysztof
K
Goch
Jan Henryk
JH
D000208:Acute Disease; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D003327:Coronary Disease / Q000097:blood / Q000175:diagnosis*; D000074026:Fatty Acid Binding Protein 3; D050556:Fatty Acid-Binding Proteins / Q000097:blood* / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000175:diagnosis*; D009206:Myocardium / Q000378:metabolism; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity; D013577:Syndrome; D020107:Troponin T / Q000097:blood
D015415:Biomarkers; C493408:FABP3 protein, human; D000074026:Fatty Acid Binding Protein 3; D050556:Fatty Acid-Binding Proteins; D020107:Troponin T