Galactoxylomannan does not exhibit cross-reactivity in the platelia Aspergillus enzyme immunoassay.
Given the recent report of a false-positive result in the Platelia Aspergillus enzyme immunoassay in a patient with cryptococcosis and in yeast extracts and purified galactoxylomannan of Cryptococcus neoformans, we evaluated culture extracts, purified polysaccharides, clinical specimens, and specimens from animals following experimental infection. Our results revealed no cross-reactions.
De Jesus
Magdia
M
Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Hackett
Emily
E
Durkin
Michelle
M
Connolly
Patricia
P
Casadevall
Arturo
A
Petraitiene
Ruta
R
Walsh
Thomas J
TJ
Wheat
L Joseph
LJ
D000818:Animals; D001232:Aspergillus fumigatus / Q000276:immunology*; D002240:Carbohydrate Sequence; D003429:Cross Reactions; D003455:Cryptococcus neoformans / Q000276:immunology*; D007124:Immunoenzyme Techniques; D051379:Mice; D008807:Mice, Inbred BALB C; D011134:Polysaccharides; D011135:Polysaccharides, Bacterial / Q000737:chemistry* / Q000276:immunology*; D011817:Rabbits
D011134:Polysaccharides; D011135:Polysaccharides, Bacterial; C043689:galactoxylomannan