title: Aripiprazole augmentation of incomplete treatment response in an adolescent male with obsessive-compulsive disorder.
abstract: We report the case of adolescent male with obsessive-compulsive disorder (OCD) who had an incomplete response to combined cognitive-behavioral therapy (CBT) and sertraline before successful augmentation of CBT with aripiprazole. Standardized assessments indicated significant reductions in OCD symptomatology associated with both initial treatment and aripiprazole augmentation. This case suggests that aripiprazole may have utility as an augmenting agent of CBT in adolescents with OCD and underscores the need for conducting controlled studies to test this hypothesis.
authors.affiliation: Department of Psychiatry, University of Florida, Gainesville, Florida 32610, USA. estorch@psychiatry.ufl.edu
authors.forename: Eric A
authors.initials: EA
authors.lastname: Storch
authors.forename: Heather
authors.initials: H
authors.lastname: Lehmkuhl
authors.forename: Gary R
authors.initials: GR
authors.lastname: Geffken
authors.forename: Alexis
authors.initials: A
authors.lastname: Touchton
authors.forename: Tanya K
authors.initials: TK
authors.lastname: Murphy
mesh_terms: D000293:Adolescent; D000928:Antidepressive Agents / Q000008:administration & dosage / Q000009:adverse effects; D014150:Antipsychotic Agents / Q000008:administration & dosage* / Q000009:adverse effects; D000068180:Aripiprazole; D015928:Cognitive Behavioral Therapy; D003131:Combined Modality Therapy; D003887:Desensitization, Psychologic; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D009771:Obsessive-Compulsive Disorder / Q000175:diagnosis / Q000188:drug therapy* / Q000523:psychology; D010879:Piperazines / Q000008:administration & dosage* / Q000009:adverse effects; D015363:Quinolones / Q000008:administration & dosage* / Q000009:adverse effects; D017367:Selective Serotonin Reuptake Inhibitors / Q000008:administration & dosage / Q000009:adverse effects; D020280:Sertraline / Q000008:administration & dosage / Q000009:adverse effects
chemical_list: D000928:Antidepressive Agents; D014150:Antipsychotic Agents; D000068180:Aripiprazole; D010879:Piperazines; D015363:Quinolones; D017367:Selective Serotonin Reuptake Inhibitors; D020280:Sertraline