title: Expansion cranioplasty with jackscrew distracters for craniosynostosis and intracranial hypertension in transplanted osteopetrosis.
abstract: BACKGROUND
  An 11-month-old boy with autosomal recessive infantile osteopetrosis presented, 7 months after bone marrow transplantation, with normal ventricular size and life-threatening intracranial hypertension due to pansynostosis.
  
  
  METHODS
  The cranial vault was expanded by using jackscrew distracters to upwardly advance the upper part of the calvarium.
  
  
  RESULTS
  The procedure achieved a 15-mm upward expansion of the cranial vault over a 15-day period, and the volume of the cranial vault was increased by 139 ml. All clinical manifestations of intracranial hypertension resolved.
  
  
  CONCLUSIONS
  Cranial vault expansion with jackscrew distracters was successful in relieving intracranial hypertension in an infant with pancraniosynostosis complicating bone marrow transplanted malignant infantile osteopetrosis.
authors.affiliation: Department of Neurosurgery, The University of Colorado Health Sciences Center and The Children's Hospital, Denver, USA.
authors.forename: Dylaan
authors.initials: D
authors.lastname: Dowlati
authors.forename: Ken R
authors.initials: KR
authors.lastname: Winston
authors.forename: Lawrence L
authors.initials: LL
authors.lastname: Ketch
authors.forename: Ralph
authors.initials: R
authors.lastname: Quinones
authors.forename: Roger
authors.initials: R
authors.lastname: Giller
authors.forename: Annalisa
authors.initials: A
authors.lastname: Frattini
authors.forename: Johan
authors.initials: J
authors.lastname: van Hove
mesh_terms: D002508:Cephalometry; D002869:Chromosome Aberrations; D003398:Craniosynostoses / Q000175:diagnosis / Q000235:genetics / Q000601:surgery*; D004252:DNA Mutational Analysis; D005500:Follow-Up Studies; D005808:Genes, Recessive / Q000235:genetics; D006580:Genetic Carrier Screening; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007231:Infant, Newborn; D019586:Intracranial Hypertension / Q000175:diagnosis / Q000601:surgery*; D008279:Magnetic Resonance Imaging; D008297:Male; D019857:Osteogenesis, Distraction / Q000295:instrumentation*; D010022:Osteopetrosis / Q000175:diagnosis / Q000235:genetics / Q000628:therapy*; D011183:Postoperative Complications / Q000175:diagnosis / Q000601:surgery*; D012086:Reoperation; D014057:Tomography, X-Ray Computed; D025262:Vacuolar Proton-Translocating ATPases / Q000235:genetics
chemical_list: C472421:TCIRG1 protein, human; D025262:Vacuolar Proton-Translocating ATPases