Serum amyloid A levels are increased in pre-eclampsia.
OBJECTIVE
The purpose of this study was to examine serum amyloid A (SAA) levels in normal pregnant and pre-eclamptic women.


METHODS
SAA levels were measured in 25 normotensive and 25 pre-eclamptic pregnant women by enzyme linked immuno-sorbent assay.


RESULTS
In pre-eclampsia, SAA level and C-reactive protein (CRP) averaged 28.2 (7.2-135) ng/l and 21 (6.13-91) mg/l, respectively, which were significantly higher than those of normal pregnancy (7.8 [4.65-24.6] ng/l and 6.05 [0.3-19] mg/l, respectively) (p < 0.05). In addition, SAA level was positively correlated to CRP (r = 0.468, p < 0.05).


CONCLUSIONS
Marked increases of both SAA level and CRP in pre-eclampsia, and their inter-relation, may at least in part contribute to the pathogenesis of pre-eclampsia.
Engin-Ustün
Yaprak
Y
Department of Obstetrics and Gynecology, School of Medicine, Inonu University, Malatya, Turkey. ustunyaprak@yahoo.com
Ustün
Yusuf
Y
Karabulut
Aysun Bay
AB
Ozkaplan
Esra
E
Meydanli
M Mutlu
MM
Kafkasli
Ayşe
A
D000328:Adult; D001724:Birth Weight; D002097:C-Reactive Protein / Q000378:metabolism*; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D005260:Female; D005865:Gestational Age; D006801:Humans; D011225:Pre-Eclampsia / Q000097:blood* / Q000473:pathology; D011247:Pregnancy / Q000097:blood*; D000685:Serum Amyloid A Protein / Q000032:analysis*
D000685:Serum Amyloid A Protein; D002097:C-Reactive Protein