Human tumor-derived vs dendritic cell-derived exosomes have distinct biologic roles and molecular profiles.
Microvesicles (MV) or exosomes are produced and secreted by tumor and normal cells. The molecular profile and functions of tumor-derived vs dendritic cell (DC)-derived MV are distinct. The former express death ligands and mediate apoptosis of activated T cells. The latter promote CD4+ T cell proliferation and may play a role in regulating T cell responses. Serving as intercellular communication networks, tumor-derived MV contribute to tumor escape, while DC-derived MV drive and regulate immune response.
Wieckowski
Eva
E
Departments of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
Whiteside
Theresa L
TL
D000818:Animals; D017209:Apoptosis / Q000276:immunology; D022162:Cytoplasmic Vesicles / Q000276:immunology* / Q000378:metabolism; D003713:Dendritic Cells / Q000276:immunology*; D005089:Exocytosis / Q000276:immunology; D006801:Humans; D009369:Neoplasms / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology