Toll-like receptor 9-independent suppression of skin inflammation by oligonucleotides.
It has been well established that cytidine-phosphate-guanosine (CpG) oligodeoxynucleotides (ODNs) activate innate and adaptive immune responses in keratinocytes by stimulating Toll-like receptor 9 (TLR9)-dependent signaling pathways. However, as Dorn et al. report, keratinocytes possess another, yet uncharacterized, TLR9-independent mechanism for the recognition of ODNs. Surprisingly, the activation of the pathway leads to suppressed chemokine production in vitro and decreased skin inflammation in vivo.
Pivarcsi
Andor
A
Clinical Allergy Research Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden. andor.pivarcsi@ki.se
D000818:Animals; D018925:Chemokines / Q000037:antagonists & inhibitors; D003872:Dermatitis / Q000378:metabolism* / Q000517:prevention & control*; D006801:Humans; D007113:Immunity, Innate / Q000187:drug effects; D016209:Interleukin-8 / Q000037:antagonists & inhibitors; D015603:Keratinocytes / Q000276:immunology / Q000378:metabolism; D009838:Oligodeoxyribonucleotides / Q000494:pharmacology; D009841:Oligonucleotides / Q000494:pharmacology*; D051217:Toll-Like Receptor 9 / Q000378:metabolism*
C408982:CPG-oligonucleotide; D018925:Chemokines; D016209:Interleukin-8; D009838:Oligodeoxyribonucleotides; D009841:Oligonucleotides; D051217:Toll-Like Receptor 9