title: High prevalence of serum autoantibodies against the amino terminal of alpha-enolase in Hashimoto's encephalopathy.
abstract: Recently, we discovered autoantibodies against the amino (NH(2))-terminal of alpha-enolase (NAE) in patients with Hashimoto's encephalopathy (HE) (83.3%; 5/6) [Fujii, A., Yoneda, M., Ito, T., Yamamura, O., Satomi, S., Higa, H., Kimura, M., Suzuki, M., Yamashita, M., Yuasa, T., Suzuki, H., Kuriyama, M., 2005. Autoantibodies against the amino terminal of alpha-enolase are a useful diagnostic marker of Hashimoto's encephalopathy. J. Neuroimmunol. 162, 130-136]. We further investigated the anti-NAE autoantibodies in 25 patients who fit the diagnostic criteria for HE, based on the presence of anti-thyroid antibodies and responsiveness to immunotherapy. In this study, we demonstrated a high prevalence (68%, 17 of 25) and high specificity of anti-NAE autoantibodies in patients with HE, and clarified the clinical features of HE. This result demonstrated that anti-NAE autoantibodies, in addition to anti-thyroid autoantibodies, are emphasized as useful serological diagnostic markers of HE.
authors.affiliation: Second Department of Internal Medicine (Neurology), Faculty of Medical Sciences, University of Fukui, Fukuii 910-1193, Japan. myoneda@fmsrsa.fukui-med.ac.jp
authors.forename: M
authors.initials: M
authors.lastname: Yoneda
authors.forename: A
authors.initials: A
authors.lastname: Fujii
authors.forename: A
authors.initials: A
authors.lastname: Ito
authors.forename: H
authors.initials: H
authors.lastname: Yokoyama
authors.forename: H
authors.initials: H
authors.lastname: Nakagawa
authors.forename: M
authors.initials: M
authors.lastname: Kuriyama
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001323:Autoantibodies / Q000097:blood*; D015153:Blotting, Western; D001927:Brain Diseases / Q000097:blood / Q000209:etiology* / Q000276:immunology*; D004591:Electrophoresis, Polyacrylamide Gel; D005260:Female; D050031:Hashimoto Disease / Q000150:complications*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010751:Phosphopyruvate Hydratase / Q000737:chemistry / Q000276:immunology*; D015995:Prevalence
chemical_list: D001323:Autoantibodies; D010751:Phosphopyruvate Hydratase