Novel synthetic approach to N-aryl-4-(3-pyridyl)thiazol-2-amine and analogues using HMCM-41 as catalyst, and their biological evaluation as human platelet aggregation inhibitors.
A novel synthetic approach to N-aryl-4-(3-pyridyl)thiazol-2-amine and analogues using HMCM-41, a mesoporous aluminosilicate catalyst and their in vitro ADP-induced platelet aggregation inhibitory activity on human blood platelets is described. Among the test compounds N-(2'-flourophenyl)-4-(3-pyridyl)thiazol-2-amine (9e) was found to be the most potent, IC(50)=4.84x10(-7)M.
Bhoga
Umadevi
U
Organic Division, Indian Institute of Chemical Technology, Hyderabad-500 007, India. ubhoga@yahoo.co.in
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000588:Amines / Q000138:chemical synthesis* / Q000494:pharmacology; D001792:Blood Platelets / Q000187:drug effects; D002384:Catalysis; D006801:Humans; D020128:Inhibitory Concentration 50; D008297:Male; D010975:Platelet Aggregation Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship
D000588:Amines; D010975:Platelet Aggregation Inhibitors; D000244:Adenosine Diphosphate