Cytokines and chemokines shaping the B-cell compartment.
The whole life of a B-cell from a stem cell to a mature plasma cell is governed, among other factors, by cytokines and growth factors in their microenvironment. Remarkable progress in the understanding of the mechanisms of cytokines action on the B-cell compartment was achieved by analysis of gene-targeted mice. The generation of mice deficient for individual cytokines or their receptors has shed light on the in vivo function of cytokines in B-cell responses. This review focuses on the role of cytokines in the development, maturation and differentiation of different B-cell subsets into antibody-secreting cells or memory B-cells.
Acosta-Rodríguez
Eva V
EV
Department of Clinical Biochemistry, School of Chemical Sciences, National University of Córdoba, Córdoba, Argentina.
Merino
Maria C
MC
Montes
Carolina L
CL
Motrán
C Cristina
CC
Gruppi
Adriana
A
D000818:Animals; D016175:B-Lymphocyte Subsets / Q000276:immunology*; D002454:Cell Differentiation / Q000276:immunology*; D018925:Chemokines / Q000276:immunology*; D016207:Cytokines / Q000276:immunology*; D006412:Hematopoietic Stem Cells / Q000276:immunology*; D006801:Humans; D007156:Immunologic Memory; D010950:Plasma Cells / Q000276:immunology*
D018925:Chemokines; D016207:Cytokines