title: Effects of surgery on ischaemic mitral regurgitation: a prospective multicentre registry (SIMRAM registry).
abstract: OBJECTIVE
  Functional ischaemic mitral regurgitation (IMR) is common in patients with ischaemic left ventricular dysfunction undergoing coronary artery bypass surgery. Although the presence of IMR negatively affects prognosis, the additional benefit of valve repair is debated, particularly with mild IMR at rest. Exercise echocardiography may help identify a subset of patients at higher risk of cardiovascular events by revealing the dynamic component of IMR.
  
  
  METHODS
  A large prospective, multicentre, non-randomized registry is designed to evaluate the effects of surgery on IMR at rest and on its dynamic component at exercise (z). SIMRAM will enrol approximately 550 patients with IMR in up to 17 centres with clinical and exercise follow-up for 1 year. Three sets of outcomes will be prospectively assessed and several hypotheses will be tested including determinants of adverse outcome and progressive left ventricular remodeling, efficacy of treatment and role of ischaemia on the dynamic consequences of IMR. Enrolment began in November 2006 and is expected to end by early 2008.
authors.affiliation: Department of Cardiology, University Hospital, CHU Sart Tilman, B-4000 Liège, Belgium. plancellotti@chu.ulg.ac.be
authors.forename: Patrizio
authors.initials: P
authors.lastname: Lancellotti
authors.forename: Erwan
authors.initials: E
authors.lastname: Donal
authors.forename: Bernard
authors.initials: B
authors.lastname: Cosyns
authors.forename: Guy
authors.initials: G
authors.lastname: Van Camp
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Monin
authors.forename: Eric
authors.initials: E
authors.lastname: Brochet
authors.forename: Alain
authors.initials: A
authors.lastname: Berrebi
authors.forename: Philippe
authors.initials: P
authors.lastname: Pibarot
authors.forename: Christophe
authors.initials: C
authors.lastname: Chauvel
authors.forename: Christian
authors.initials: C
authors.lastname: Hassager
authors.forename: Gabriele
authors.initials: G
authors.lastname: Tumminello
authors.forename: Christophe
authors.initials: C
authors.lastname: Tribouilloy
authors.forename: Stéphane
authors.initials: S
authors.lastname: Lafitte
authors.forename: Alan G
authors.initials: AG
authors.lastname: Fraser
authors.forename: Genevieve
authors.initials: G
authors.lastname: Derumeaux
authors.forename: George
authors.initials: G
authors.lastname: Athanassopoulos
authors.forename: Jeroen
authors.initials: J
authors.lastname: Bax
authors.forename: Luc A
authors.initials: LA
authors.lastname: Piérard
mesh_terms: D002170:Canada; D001026:Coronary Artery Bypass; D015150:Echocardiography, Doppler; D005060:Europe; D005080:Exercise Test; D005260:Female; D006801:Humans; D008297:Male; D008944:Mitral Valve Insufficiency / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000601:surgery*; D017202:Myocardial Ischemia / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000601:surgery*; D011446:Prospective Studies; D012042:Registries; D016896:Treatment Outcome