Therapeutic efficiency of early and late administration of surfactant-BL during bleomycin-induced damage to rat lungs.
Surfactant-BL was administered to rats via the inhalation route from day 1 or day 8 after intratracheal injection of bleomycin. Bronchoalveolar lavage and morphological characteristics of the lungs were compared. Administration of surfactant-BL at the early terms efficiently reduced the severity of bleomycin-induced alveolitis and atelectases.
Volchkov
V A
VA
Central Research Radiology Institute, Ministry of Health of the Russian Federation, St. Petersburg. volchkov@mail.rcom.ru
Dubrovskaya
V F
VF
Klestova
O V
OV
Val'kovich
A A
AA
Serzhanina
V A
VA
Seiliev
A A
AA
Rosenberg
O A
OA
D000280:Administration, Inhalation; D000818:Animals; D001761:Bleomycin / Q000633:toxicity*; D018893:Bronchoalveolar Lavage; D007962:Leukocytes / Q000276:immunology; D008168:Lung / Q000648:ultrastructure; D008171:Lung Diseases / Q000139:chemically induced* / Q000188:drug therapy* / Q000473:pathology; D008264:Macrophages / Q000276:immunology; D008297:Male; D001261:Pulmonary Atelectasis / Q000188:drug therapy*; D011663:Pulmonary Surfactants / Q000008:administration & dosage / Q000627:therapeutic use*; D051381:Rats; D013997:Time Factors
D011663:Pulmonary Surfactants; D001761:Bleomycin