Protein C inhibitor, a serpin with functions in- and outside vascular biology.
Human protein C inhibitor (PCI), a serpin-type protease inhibitor originally described as an inhibitor of activated protein C, has broad protease reactivity. In addition to its activities within the blood clotting and fibrinolytic cascades, it seems to participate in several biological processes including reproduction and tumor growth. This review summarizes the current understanding of PCI function, regulation, and potential biological role.
Geiger
Margarethe
M
Department of Vascular Biology and Thrombosis Research, Center for Biomolecular Medicine and Pharmacology, Medical University of Vienna, Vienna, Austria. margarethe.geiger@meduniwien.ac.at
D000818:Animals; D004730:Endothelium, Vascular / Q000378:metabolism*; D006487:Hemostasis; D006801:Humans; D023421:Models, Animal; D009369:Neoplasms / Q000378:metabolism; D018046:Protein C Inhibitor / Q000378:metabolism*; D012098:Reproduction
D018046:Protein C Inhibitor