title: Increased striatal gray matter densities in patients with schizophrenia and substance use disorder: a voxel-based morphometry study.
abstract: We sought to investigate the link between substance abuse and increased striatal gray matter densities (GMD) in schizophrenia, using voxel-based morphometry (VBM). Increased striatal GMD were found in patients with schizophrenia and substance use disorder (n=12), but not schizophrenia only patients (n=11), compared to healthy volunteers (n=15).
authors.affiliation: Department of Psychiatry, Fernand-Seguin Research Center, University of Montreal, Canada.
authors.forename: Stéphane
authors.initials: S
authors.lastname: Potvin
authors.forename: Adham
authors.initials: A
authors.lastname: Mancini-Marïe
authors.forename: Chérine
authors.initials: C
authors.lastname: Fahim
authors.forename: Boualem
authors.initials: B
authors.lastname: Mensour
authors.forename: Johanne
authors.initials: J
authors.lastname: Lévesque
authors.forename: Sherif
authors.initials: S
authors.lastname: Karama
authors.forename: Mario
authors.initials: M
authors.lastname: Beauregard
authors.forename: Pierre-Paul
authors.initials: PP
authors.lastname: Rompré
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Stip
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000494:pharmacology / Q000627:therapeutic use; D002452:Cell Count; D003342:Corpus Striatum / Q000187:drug effects / Q000473:pathology*; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D006220:Haloperidol / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D017448:Receptors, Dopamine D2 / Q000187:drug effects; D012559:Schizophrenia / Q000188:drug therapy / Q000453:epidemiology / Q000473:pathology; D012720:Severity of Illness Index; D019966:Substance-Related Disorders / Q000175:diagnosis / Q000453:epidemiology*
chemical_list: D014150:Antipsychotic Agents; D017448:Receptors, Dopamine D2; D006220:Haloperidol