Understanding and minimizing late thrombosis of drug-eluting stents.
Although the safety profiles of drug-eluting stents are similar to those of bare metal stents in the short term, concern has arisen about their potential for late thrombosis (occurring > 30 days after implantation). Stent thrombosis is rare but potentially devastating and can result in ST-segment elevation myocardial infarction or death. The aim of this article is to review the incidence, predictors, pathology, and prevention of late thrombosis of drug-eluting stents.
Rabbat
Mark G
MG
Department of Internal Medicine, Cleveland Clinic, OH 44195, USA.
Bavry
Anthony A
AA
Bhatt
Deepak L
DL
Ellis
Stephen G
SG
D015906:Angioplasty, Balloon, Coronary / Q000295:instrumentation; D000077144:Clopidogrel; D023903:Coronary Restenosis / Q000517:prevention & control; D016503:Drug Delivery Systems; D006801:Humans; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage / Q000009:adverse effects*; D012307:Risk Factors; D015607:Stents; D013923:Thromboembolism / Q000139:chemically induced*; D013988:Ticlopidine / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D013997:Time Factors
D010975:Platelet Aggregation Inhibitors; D000077144:Clopidogrel; D013988:Ticlopidine