Modeling protein-protein complexes involved in the cytochrome C oxidase copper-delivery pathway.
Proper assembly and function of cytochrome c oxidase, which catalyzes the reduction of O2 and generates the proton gradient driving ATP synthesis, depend on correct copper delivery and incorporation. Structural details about the protein-protein complexes involved in this process are still missing. We describe here models of four complexes along this pathway obtained by combining bioinformatics interface predictions with information-driven docking and discuss their relevance with respect to known and pathogenic mutations.
van Dijk
Aalt D J
AD
Bijvoet Center for Biomolecular Research, Science Faculty, Utrecht University, 3584CH, Utrecht, The Netherlands.
Ciofi-Baffoni
Simone
S
Banci
Lucia
L
Bertini
Ivano
I
Boelens
Rolf
R
Bonvin
Alexandre M J J
AM
D019295:Computational Biology; D003300:Copper / Q000737:chemistry / Q000378:metabolism*; D030401:Cytochrome-c Oxidase Deficiency / Q000235:genetics / Q000378:metabolism; D003576:Electron Transport Complex IV / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008958:Models, Molecular; D009154:Mutation; D011487:Protein Conformation
D003300:Copper; D003576:Electron Transport Complex IV