Cross-talk between apoptosis and cytokines in the regulation of parasitic infection.
Parasitic diseases have worldwide medical and economical impact. Host T lymphocytes and the cytokines they produce determine the outcome of parasitic infections. Programmed cell death by apoptosis is induced in the course of parasitic infections, and affects cytokine production by removing activated effector T and B cells. In addition, engulfment of apoptotic cells promotes the secretion of cytokines that regulate intracellular replication of protozoan parasites. In this review, we discuss how the cross-talk between apoptosis and cytokines regulates parasitic infection.
DosReis
George A
GA
Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Centro de Ciências da Saúde, Bloco G, Ilha do Fundão, Rio de Janeiro, RJ 21949-900, Brazil. gdosreis@biof.ufrj.br
Ribeiro-Gomes
Flavia L
FL
Guillermo
Landi V C
LV
Lopes
Marcela F
MF
D000818:Animals; D017209:Apoptosis / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology*; D016207:Cytokines / Q000276:immunology*; D006801:Humans; D011528:Protozoan Infections / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
D016207:Cytokines