title: Profiling of peritoneal fluid of women with endometriosis by chemokine protein array.
abstract: OBJECTIVE
  Chemokines play essential role not only in controlling leukocyte function and trafficking but also in the angiogenesis and modulation of inflammatory responses.
  
  
  METHODS
  A novel array-based enzyme-linked immunosorbent assay was used to quantitate peritoneal fluid chemokines of 25 infertile women with endometriosis and 18 controls. For our preliminary studies we chose mini-array containing nine different chemokines: MDC/CCL22, TARC/CCL17, MCP-1/CCL2, RANTES/CCL5, MIP-1alpha/CCL3, -1beta/CCL4, -1delta/CCL15, -3alpha/CCL20, and -3beta/CCL19.
  
  
  RESULTS
  We found significantly higher MIP-3beta/CCL19 (P = 0.0036) concentrations in peritoneal fluid of women with endometriosis as compared to patients with primary infertility without any signs of disease.
  
  
  CONCLUSIONS
  Our preliminary results suggest that MIP-3beta/ /CCL19 might play a role in the pathogenesis of endometriosis but its precise role remains to be established. Novel types of screening methods based on high-throughput technologies offer great opportunities to study immunobiology of endometriosis. It will hopefully provide new possibilities for discovery of new markers and potential drug targets.
authors.affiliation: Department of Pathophysiology of Pregnancy, Medical University of Białystok, Poland. plauda@cksr.ac.bialystok.pl
authors.forename: P
authors.initials: P
authors.lastname: Laudański
authors.forename: J
authors.initials: J
authors.lastname: Szamatowicz
authors.forename: M
authors.initials: M
authors.lastname: Oniszczuk
mesh_terms: D000328:Adult; D001202:Ascitic Fluid / Q000378:metabolism*; D018925:Chemokines / Q000378:metabolism*; D004715:Endometriosis / Q000378:metabolism* / Q000473:pathology; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000378:metabolism / Q000473:pathology
chemical_list: D018925:Chemokines