Analysing the favourable effects of physical exercise: relationships between physical fitness, fatigue and functioning in Guillain-Barré syndrome and chronic inflammatory demyelinating polyneuropathy.
OBJECTIVE
To elucidate the effects of physical exercise in severely fatigued patients with Guillain-Barré syndrome and chronic inflammatory demyelinating polyneuropathy, and to clarify the mutual relationships between 5 domains studied in these patients: physical fitness, fatigue, objectively measured actual mobility, perceived physical functioning, and perceived mental functioning.


METHODS
Case series.


METHODS
Twenty patients with Guillain-Barré syndrome and chronic inflammatory demyelinating polyneuropathy.


METHODS
The patients undertook a 12-week physical exercise program. Relationships between domains were studied in the change scores, and additionally in the baseline data of patients. The percentage of significant relationships between each pair of domains was determined.


RESULTS
In the change scores, a small percentage of significant relationships was found between the physical fitness domain and the other 4 domains (2/30, 7%). A higher percentage of significant relationships was found between the domains perceived mental functioning and actual mobility (44%), perceived mental functioning and perceived physical functioning (44%), and between fatigue and perceived physical functioning (33%). Generally, similar patterns were found in the baseline data.


CONCLUSIONS
Changes in fatigue, actual mobility and perceived functioning seem not to be influenced by changes in physical fitness. This study stresses the presence and importance of additional effects of a physical training program, not directly related to increasing fitness.
Bussmann
Johannes B J
JB
Department of Rehabilitation Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands. j.b.j.bussmann@erasmusmc.nl
Garssen
Marcel P
MP
van Doorn
Pieter A
PA
Stam
Henk J
HJ
D000203:Activities of Daily Living; D000328:Adult; D005081:Exercise Therapy; D005221:Fatigue / Q000175:diagnosis; D005260:Female; D020275:Guillain-Barre Syndrome / Q000503:physiopathology / Q000523:psychology / Q000534:rehabilitation*; D006801:Humans; D008297:Male; D008603:Mental Health; D008875:Middle Aged; D010809:Physical Fitness; D020277:Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / Q000503:physiopathology / Q000523:psychology / Q000534:rehabilitation*; D012649:Self Concept; D011795:Surveys and Questionnaires; D016896:Treatment Outcome