Polyamidoamine (PAMAM) dendrimers as biocompatible carriers of quinolone antimicrobials: an in vitro study.
Quinolones, an expanding class of clinically established potent antibiotics, is not freely soluble in water which prevents the design of liquid dosage forms and restricts their use in topical applications. In the present study we investigated the potential of polyamidoamine (PAMAM) dendrimers as drug carriers of quinolones (nadifloxacin and prulifloxacin) by aqueous solubility and antibacterial activity studies. Results showed that the aqueous solubility of nadifloxacin and prulifloxacin was significantly increased by PAMAM dendrimers. Microbiology studies showed that nadifloxacin and prulifloxacin still exhibit their strong antimicrobial activities in the presence of dendrimers. These studies indicated that PAMAM dendrimers might be considered as biocompatible carriers of quinolones under suitable conditions.
Cheng
Yiyun
Y
Laboratory of Functional Membranes, Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, China. yycheng@mail.ustc.edu.cn
Qu
Haiou
H
Ma
Minglu
M
Xu
Zhenhua
Z
Xu
Peng
P
Fang
Yujie
Y
Xu
Tongwen
T
D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D050091:Dendrimers / Q000737:chemistry*; D004148:Dioxolanes / Q000737:chemistry* / Q000494:pharmacology; D004337:Drug Carriers / Q000737:chemistry; D004926:Escherichia coli / Q000187:drug effects; D024841:Fluoroquinolones / Q000737:chemistry* / Q000494:pharmacology; D010879:Piperazines / Q000737:chemistry* / Q000494:pharmacology; D011073:Polyamines / Q000737:chemistry*; D011807:Quinolizines / Q000737:chemistry* / Q000494:pharmacology; D015363:Quinolones / Q000737:chemistry* / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D050091:Dendrimers; D004148:Dioxolanes; D004337:Drug Carriers; D024841:Fluoroquinolones; D010879:Piperazines; D011073:Polyamines; D011807:Quinolizines; D015363:Quinolones; C062127:nadifloxacin; C074191:prulifloxacin