A study on functional similarity between dengue non structural protein 1 and platelet integrin/adhesin protein, CD61.
BACKGROUND
Dengue infection is a major public health problem. The mechanisms underlying severe bleeding in dengue DHF are not completely understood. It was proposed that the dengue virus nonstructural-1 protein (DNS1) generated antibodies to common epitopes on human blood clotting and integrin/adhesin proteins on the platelet. The proof on the functional correlation between DNS1 and platelet integrin/adhesin proteins is needed.


METHODS
Here, the author used a new gene ontology technology to predict the molecular function and biological process of DNS1 and platelet integrin/adhesin protein, CD61.


RESULTS
According to this study, the author can identify no function and biological process of DNS1. Also, there is no existence of functional similarity between DNS1 and CD61.


CONCLUSIONS
The hypothesis on role of molecular mimicry between DNS1 and CD61 is not supported in this study.
Wiwanitkit
Viroj
V
Department of Laboratory Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand 10330. wviroj@pioneer.netserv.chula.ac.th
D000465:Algorithms; D003716:Dengue Virus; D006801:Humans; D039661:Integrin beta3 / Q000502:physiology*; D018716:Molecular Mimicry; D017361:Viral Nonstructural Proteins / Q000502:physiology*
D039661:Integrin beta3; D017361:Viral Nonstructural Proteins