[Creatinine clearance estimation in the extremely elderly subjects].
BACKGROUND
It has been reported that elderly outpatients take at least 6 different kinds of medication.


OBJECTIVE
To know which formula will best predict creatinine clearance, because 24-hour urine collection is difficult for elderly outpatients.


METHODS
We compared four types of formulae (Cockcroft and Gault, Yasuda, Orita, Walser) to estimate creatinine clearance using serum creatinine of 143 elderly inpatients (73 men, 70 women, mean age 82.9 +/- 8.6 years old) including 67 extremely elderly people with various underlying diseases.


RESULTS
The formula of Cockcroft and Gault showed the best correlation with creatinine clearance in the extremely elderly subjects (r = 0.74) as well as in people under 85 years (r = 0.76). However, the estimated values of the extremely elderly women were lower than actual creatinine clearance.


CONCLUSIONS
The formula of Cockcroft and Gault is the best predictive equation of creatinine clearance, except in the extremely elderly women.
Hirayama
Shunichi
S
Tokyo University of Pharmacy and Life Science.
Kikuchi
Reiko
R
Inoue
Shinichiro
S
Tsukahara
Daisuke
D
Suemitsu
Yumi
Y
Kobayashi
Yoshio
Y
Sugiyama
Yoichi
Y
Hasegawa
Hiroshi
H
Kouzaki
Koichi
K
Inoue
Gosuke
G
Toba
Kenji
K
D000369:Aged, 80 and over; D003404:Creatinine / Q000652:urine*; D005260:Female; D006801:Humans; D007677:Kidney Function Tests / Q000379:methods*; D008297:Male; D008657:Metabolic Clearance Rate; D011237:Predictive Value of Tests; D013997:Time Factors
D003404:Creatinine