Donepezil in the treatment of musical hallucinations.
Musical hallucinations (MH) typically occur among elderly individuals and are associated with hearing impairment. The authors describe a patient with features of typical MH who was successfully treated with donepezil, a cholinesterase inhibitor, as a combination therapy and who has not shown any subsequent cognitive decline for approximately 5 years. The efficacy of donepezil in this patient indicates that age-dependent dysfunction of cholinergic neurons might be related to the development of MH.
Ukai
Satoshi
S
Department of Psychiatry and Behavioral Science, Osaka University Graduate School of Medicine, Osaka, Japan. ukai@wakayama-med.ac.jp
Yamamoto
Masakiyo
M
Tanaka
Michio
M
Shinosaki
Kazuhiro
K
Takeda
Masatoshi
M
D000369:Aged, 80 and over; D000077265:Donepezil; D004359:Drug Therapy, Combination; D005260:Female; D006212:Hallucinations / Q000188:drug therapy* / Q000523:psychology; D006311:Hearing Disorders / Q000150:complications; D006801:Humans; D007189:Indans / Q000627:therapeutic use*; D009146:Music / Q000523:psychology*; D018697:Nootropic Agents / Q000627:therapeutic use*; D010880:Piperidines / Q000627:therapeutic use*
D007189:Indans; D018697:Nootropic Agents; D010880:Piperidines; D000077265:Donepezil