Probing nucleoid structure in bacteria using phage lambda integrase-mediated chromosome rearrangements.
Conservative site-specific recombination has been adapted for a multitude of uses, in both prokaryotes and eukaryotes, including genetic engineering, expression technologies, and as probes of chromosome structure and organization. In this article, we give a specific example of the latter application, and a quick summary of some of the myriad other genetic and biotechnology applications of site-specific recombination.
Garcia-Russell
Nathalie
N
Department of Biology, San Diego State University, San Diego, CA, USA.
Orchard
Samantha S
SS
Segall
Anca M
AM
D010582:Bacteriophage lambda / Q000201:enzymology* / Q000235:genetics*; D002876:Chromosomes, Bacterial; D019426:Integrases / Q000378:metabolism*
D019426:Integrases