[Studies on using spray drying technique in preparing Ophiopogon japonicus saponin enteric microsphere by orthogonal experimental design].
OBJECTIVE
To explore the best technique parameters on preparing ophiopogon japonicus saponin enteric microsphere by spray drying technique.


METHODS
The best technique parameters were investigated by orthogonal experimental design and by the target, such as surface appearances, encapsulated efficiency, etc.


RESULTS
The best technique parameters included the inlet temperature (90 degrees C ), the feeding speed (10 mL x min(- 1)), and the rotate speed of atomizer (50 r x min(-1)).


CONCLUSIONS
Ophiopogon japonicus saponin enteric microsphere accorded with the expecting demand. The main influencing factor was inlet temperature . It is suitable to industrialize in preparing Traditional Chinese Medicine microsphere.
Shen
Lan
L
Shanghai University of traditional Chinese medicine, Shanghai 201203, China.
Feng
Yi
Y
Xu
De-sheng
DS
Lin
Xiao
X
D004339:Drug Compounding / Q000379:methods*; D008854:Microscopy, Electron; D008863:Microspheres; D031441:Ophiopogon / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification*; D013608:Tablets, Enteric-Coated / Q000737:chemistry; D013696:Temperature
D012503:Saponins; D013608:Tablets, Enteric-Coated