Introduction to chemical proteomics for drug discovery and development.
A fundamental goal of chemical proteomics is to identify target proteins for bioactive small molecules and then apply them to drug discovery and development as valid and drugable targets. Here, we introduce integrated technologies for the rapid identification of target proteins, methodologies for validating them as drugable targets, and applications of chemical proteomics in drug discovery and development.
Han
Sung-Young
SY
Department of Chemistry, University of Texas at Dallas, Richardson, TX, USA.
Hwan Kim
Seong
S
D001665:Binding Sites; D002853:Chromatography, Liquid; D015195:Drug Design; D013058:Mass Spectrometry; D015335:Molecular Probes; D053758:Nanoparticles; D010455:Peptides / Q000737:chemistry; D019920:Photoaffinity Labels; D011506:Proteins / Q000737:chemistry; D040901:Proteomics; D020349:Surface Plasmon Resonance
D015335:Molecular Probes; D010455:Peptides; D019920:Photoaffinity Labels; D011506:Proteins