Pharmacokinetics of florfenicol, thiamphenicol, and chloramphenicol in turkeys.
The pharmacokinetics of florfenicol (FF), thiamphenicol (TP) and chloramphenicol (CP) after single intravenous (i.v.) or oral (p.o.) administration was studied in an independent cross-over study in broiler turkeys. All the fenicol antibiotics were administered at a dose of 30 mg/kg b.w. and their concentrations in plasma samples were assayed using the same validated high-performance liquid chromatography method. Pharmacokinetic parameters were calculated by a noncompartmental method. The kinetic profiles of the compounds were compared with the results of the structure-activity relationship. According to the proposed mathematical description, no differences in plasma clearance values for the studied antibiotics were observed. The mean residence time values of FF, TF, and CP after i.v. injection were 3.37+/-0.63, 2.43+/-0.29, and 2.12+/-0.21 h, respectively. The mean values of Varea for FF (1.39+/-0.31 L/kg) and TP (1.31+/-0.19 L/kg) were similar, but significantly different from that of CP (1.04+/-0.12 L/kg). The bioavailabilities of FF, TP, and CP after oral administration were 82%, 69%, and 45%, respectively. Differences in the bioavailability values of the compared fenicol antibiotics correspond to the ratio of the apolar/polar surface areas of their particles.
Switała
M
M
Department of Biochemistry, Pharmacology and Toxicology, Agricultural University of Wroclaw, Wroclaw, Poland. switala@ozi.ar.wroc.pl
Hrynyk
R
R
Smutkiewicz
A
A
Jaworski
K
K
Pawlowski
P
P
Okoniewski
P
P
Grabowski
T
T
Debowy
J
J
D000284:Administration, Oral; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D019540:Area Under Curve; D002701:Chloramphenicol / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics; D018592:Cross-Over Studies; D005260:Female; D007262:Infusions, Intravenous / Q000662:veterinary; D013839:Thiamphenicol / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000097:blood / Q000493:pharmacokinetics; D014422:Turkeys / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D002701:Chloramphenicol; C035534:florfenicol; D013839:Thiamphenicol