[Effects of insulin-like growth factor-1 on the regulation of hypothalamus-hypophysis-testis axis].
It has been demonstrated that insulin-like growth factor-1 (IGF-1) stimulates the proliferation and division of cells, facilitates the individual growth and development and regulates the material metabolism. Furthermore, it regulates male reproductive development and testicular endocrine functions. IGF-1 can stimulate the expression of GnRH gene in the hypothalamus of prepubertal male mice. However, it has no effect on or even inhibits GnRH gene expression in adult mice. IGF-1 may influence the growth, maturation and differentiation of GnRH neurons. It also accelerates LH and FSH secretion in hypophysis. IGF-1, produced locally in the testis and combined with its specific receptor, can regulate the proliferation and differentiation of adult Leydig cells, cause Sertoli cells to play different functions and control the biosynthesis of testicular hormones.
Liu
Xiao-ping
XP
Department of Physiology, Shantou University Medical College, Shantou, Guangdong 515041, China. xiaoxiaoliu1982@163.com
Wang
Yong
Y
Qin
Da-nian
DN
D000818:Animals; D005786:Gene Expression Regulation; D007987:Gonadotropin-Releasing Hormone / Q000096:biosynthesis; D007030:Hypothalamo-Hypophyseal System / Q000378:metabolism / Q000502:physiology*; D007334:Insulin-Like Growth Factor I / Q000502:physiology*; D007985:Leydig Cells / Q000502:physiology; D008297:Male; D051379:Mice; D012708:Sertoli Cells / Q000502:physiology; D013737:Testis / Q000378:metabolism / Q000502:physiology*
D007987:Gonadotropin-Releasing Hormone; D007334:Insulin-Like Growth Factor I