title: Travoprost 0.004%/timolol 0.5% fixed combination.
abstract: Fixed-combination travoprost/timolol solution consists of travoprost 0.004% and timolol 0.5%. Several studies have demonstrated the efficacy and safety of this medication used once daily for the treatment of open-angle glaucoma and ocular hypertension. This fixed combination has been compared to travoprost and timolol used concomitantly, latanoprost and timolol used concomitantly, latanoprost/timolol fixed combination and travoprost and timolol monotherapy. Fixed-combination medicines such as travoprost/timolol offer the potential of maximizing patient adherence by decreasing the burden of using multiple topical agents that lower intraocular pressure, and by potentially decreasing the overall cost to both the patient and the health-care system. We discuss the benefits of fixed-dose medications, report on previous clinical trials and summarize the existing data on the performance of travoprost/timolol.
authors.affiliation: UPMC Eye Center, Eye and Ear Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA. noeckerrj@upmc.edu
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Noecker
authors.forename: Nida S
authors.initials: NS
authors.lastname: Awadallah
authors.forename: Malik Y
authors.initials: MY
authors.lastname: Kahook
mesh_terms: D000959:Antihypertensive Agents / Q000008:administration & dosage*; D002986:Clinical Trials as Topic; D003008:Cloprostenol / Q000008:administration & dosage / Q000031:analogs & derivatives*; D004338:Drug Combinations; D005902:Glaucoma, Open-Angle / Q000188:drug therapy*; D006801:Humans; D009798:Ocular Hypertension / Q000188:drug therapy*; D013999:Timolol / Q000008:administration & dosage*; D000069557:Travoprost
chemical_list: D000959:Antihypertensive Agents; D004338:Drug Combinations; D003008:Cloprostenol; D013999:Timolol; D000069557:Travoprost