title: Inhibition of mast cell histamine release by flavonoids and biflavonoids.
abstract: The effect of 11 flavonoids and 4 biflavonoids on the release of histamine from peritoneal rat mast cells induced by compound 48/80 and calcium ionophore A23187 was studied. Dihydroflavonoids (flavanones) and (+)-catechin did not modify histamine release induced by both secretagogues. Flavone, apigenin and cromoglycate inhibited the secretion elicited by compound 48/80 but did not modify the A23187-induced secretion. The effect of kaempferol on the compound 48/80-induced histamine release was biphasic. Low doses (10 (-6) to 10 (-5)M) of the compound potentiated secretion whereas higher doses inhibited histamine secretion. Some of the drugs tested revealed a higher potency as referred to quercetin. Luteolin, a tetrahydroxyflavone and amentoflavone, a biapigenin, exhibited the highest inhibitory effects of mast cell histamine secretion.
authors.affiliation: Laboratoire d'Allergopharmacologie, Faculté de Pharmacie, B. P. 10, F-67048 Strasbourg Cedex, France.
authors.forename: M
authors.initials: M
authors.lastname: Amellal
authors.forename: C
authors.initials: C
authors.lastname: Bronner
authors.forename: F
authors.initials: F
authors.lastname: Briancon
authors.forename: M
authors.initials: M
authors.lastname: Haag
authors.forename: R
authors.initials: R
authors.lastname: Anton
authors.forename: Y
authors.initials: Y
authors.lastname: Landry