Use of environmentally enriched housing for rats with spinal cord injury: the need for standardization.
A variety of rehabilitation methods that increase social interaction and locomotor activity are reported to yield positive benefits in humans and animals with spinal cord injury (SCI). Environmental enrichment often incorporates group housing, increased cage size, and objects to increase social interaction and stimulate locomotor activity of animals. Others have reported that adult rats housed in enriched environments immediately after moderate contusion thoracic SCI show improvements in locomotion, but not in neurotransmission through or anatomy at the SCI site. In the present study, in contrast to previous reports, environmental enrichment did not improve the locomotion of rats with contusion thoracic SCI. Furthermore, as in previous reports, improvements were not observed for either electrophysiologic measures of neurotransmission through (transcranial magnetic motor-evoked potentials) and caudal to (magnetic-evoked interlimb reflex) the injury site or the amount of spared white matter at the epicenter. Determining the effectiveness of environmental enrichment to improve locomotor recovery in the SCI model requires standardization of housing procedures, outcome measures, and analyses.
Burke
Darlene A
DA
Kentucky Spiral Cord Injury Research Center, Department of Neurological Surgery, Office of Research Services, University of Louisville, KY, USA.
Magnuson
David S K
DS
Nunn
Christine D
CD
Fentress
Kimberly G
KG
Wilson
Mary L
ML
Shum-Siu
Alice H
AH
Moore
Meika C
MC
Turner
Logan E
LE
King
William W
WW
Onifer
Stephen M
SM
D000818:Animals; D001522:Behavior, Animal; D004195:Disease Models, Animal; D004594:Electrophysiology; D005260:Female; D006799:Housing, Animal / Q000592:standards*; D007756:Laboratory Animal Science / Q000592:standards*; D051381:Rats; D017207:Rats, Sprague-Dawley / Q000502:physiology*; D013119:Spinal Cord Injuries / Q000534:rehabilitation*