title: Postictal suppression correlates with therapeutic efficacy for depression in bilateral sine and pulse wave electroconvulsive therapy.
abstract: Ictal electroencephalography (EEG) parameters in electroconvulsive therapy (ECT) for depression reportedly correlate with therapeutic response and stimulus dosage, particularly in right unilateral (RUL) ECT. The authors examined ictal EEG parameters as predictors of therapeutic effectiveness in bilateral (BL) sine and pulse wave ECT. A total of 30 consecutive depressed inpatients who had not responded to standard pharmacotherapy were treated using BL ECT given in either sine or pulse wave mode. Ictal EEG parameters (e.g. regularity, postictal suppression) were manually rated by three trained psychiatrists. Polyspike phase duration was significantly longer in sine wave ECT than in pulse wave ECT. Postictal suppression emerged as the only significant predictor of therapeutic outcome when baseline Hamilton Rating Scale for Depression and mode of stimulation were controlled for. Postictal suppression appears to offer a useful predictor of clinical outcome of depression in BL ECT. No EEG parameters were found to be differentially predictive between sine and pulse wave ECT.
authors.affiliation: Department of Psychiatry and Cognitive-Behavioral Medicine, Nagoya City University Graduate School of Medical Sciences, Mizuho-cho, Mizuho-ku, Nagoya, Japan. azma@med.nagoya-cu.ac.jp
authors.forename: Hideki
authors.initials: H
authors.lastname: Azuma
authors.forename: Akiko
authors.initials: A
authors.lastname: Fujita
authors.forename: Kiyoe
authors.initials: K
authors.lastname: Sato
authors.forename: Keiko
authors.initials: K
authors.lastname: Arahata
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Otsuki
authors.forename: Miki
authors.initials: M
authors.lastname: Hori
authors.forename: Yoshihito
authors.initials: Y
authors.lastname: Mochida
authors.forename: Megumi
authors.initials: M
authors.lastname: Uchida
authors.forename: Tomoko
authors.initials: T
authors.lastname: Yamada
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Akechi
authors.forename: Toshi A
authors.initials: TA
authors.lastname: Furukawa
mesh_terms: D003866:Depressive Disorder / Q000503:physiopathology* / Q000523:psychology / Q000628:therapy*; D004565:Electroconvulsive Therapy; D004569:Electroencephalography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011569:Psychiatric Status Rating Scales; D012044:Regression Analysis; D012640:Seizures / Q000503:physiopathology*