title: Stage, survival and delays in lung, colorectal, prostate and ovarian cancer: comparison between diagnostic routes.
abstract: BACKGROUND
  Very few studies have reported cancer outcomes of patients referred through different routes, despite the prominence of current UK cancer urgent referral guidance.
  
  
  OBJECTIVE
  This study aimed to compare outcomes of cancer patients referred through the urgent referral guidance with those who were not, with respect to stage at diagnosis, survival, and delays in diagnosis.
  
  
  METHODS
  Analysis of hospital records.
  
  
  METHODS
  One hospital trust in England.
  
  
  METHODS
  The records of 889 patients diagnosed in 2000-2001 with one of four types of cancer were analysed: 409 with lung cancer; 239 with colorectal cancer; 146 with prostate cancer; and 95 with ovarian cancer. Outcome measures were diagnostic stage, survival, referral and secondary care delays.
  
  
  RESULTS
  For lung cancer, urgent referrals had more advanced TNM (tumor, node, metastasis) stage than patients diagnosed through other routes (P = 0.035) and poorer survival (P = 0.020). There was no difference in stage or survival for the other cancers. For each cancer, a higher proportion of urgent referrals was seen within 2 weeks. Secondary care delays for lung and colorectal cancer were shorter for inter-specialty referrals.
  
  
  CONCLUSIONS
  For patients with lung cancer, the guidance appears to be prioritising those in the more advanced stages of disease. This was not the case for the other three cancers. Referral delays were shorter for patients urgently referred, as is the intention of the guidance. The avoidance of delays in outpatient diagnostics probably accounts for shorter secondary care delays for inter-specialty referrals.
authors.affiliation: Department of General Practice, Centre for Health Sciences Research, North Wales Clinical School, Cardiff University, Wrexhamm, Leeds, UK. nealrd@cf.ac.uk
authors.forename: Richard D
authors.initials: RD
authors.lastname: Neal
authors.forename: Victoria L
authors.initials: VL
authors.lastname: Allgar
authors.forename: Nasreen
authors.initials: N
authors.lastname: Ali
authors.forename: Brenda
authors.initials: B
authors.lastname: Leese
authors.forename: Phil
authors.initials: P
authors.lastname: Heywood
authors.forename: Gill
authors.initials: G
authors.lastname: Proctor
authors.forename: Joyce
authors.initials: J
authors.lastname: Evans
mesh_terms: D015179:Colorectal Neoplasms / Q000175:diagnosis / Q000401:mortality / Q000473:pathology; D042241:Early Diagnosis; D005194:Family Practice; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis / Q000401:mortality / Q000473:pathology; D008297:Male; D010051:Ovarian Neoplasms / Q000175:diagnosis / Q000401:mortality / Q000473:pathology; D017410:Practice Guidelines as Topic / Q000592:standards*; D011471:Prostatic Neoplasms / Q000175:diagnosis / Q000401:mortality / Q000473:pathology; D012017:Referral and Consultation / Q000592:standards* / Q000706:statistics & numerical data; D016019:Survival Analysis; D014850:Waiting Lists