Effects of acute antipsychotic treatment on brain activation in first episode psychosis: an fMRI study.
This study aimed to assess the neurophysiological effects of acute atypical antipsychotic treatment on cognitive functioning in subjects presenting with a first episode of psychosis. We used functional MRI to examine the modulatory effects of acute psychopharmacological intervention on brain activation during four different cognitive tasks: overt verbal fluency, random movement generation, n-back and a spatial object memory task. Treatment with atypical antipsychotics was associated with alterations in regional activation during each task and also when task demands were manipulated within paradigms. The initial treatment of psychosis with atypical antipsychotics thus appears to be associated with modifications of the neurofunctional correlates of executive and mnemonic functions. These effects need to be considered when interpreting group differences in activation between medicated patients and controls.
Fusar-Poli
P
P
Division of Psychological Medicine Institute of Psychiatry, King's College London, De Crespigny Park, SE58AF, London, UK. p.fusar@libero.it
Broome
M R
MR
Matthiasson
P
P
Williams
S C R
SC
Brammer
M
M
McGuire
P K
PK
D000328:Adult; D014150:Antipsychotic Agents / Q000494:pharmacology*; D001245:Association Learning / Q000187:drug effects / Q000502:physiology*; D001921:Brain / Q000187:drug effects* / Q000473:pathology / Q000503:physiopathology*; D001931:Brain Mapping; D003071:Cognition / Q000187:drug effects; D006801:Humans; D007092:Imagination / Q000187:drug effects / Q000502:physiology; D008279:Magnetic Resonance Imaging; D008568:Memory / Q000187:drug effects / Q000502:physiology; D009043:Motor Activity / Q000187:drug effects; D009068:Movement / Q000187:drug effects / Q000502:physiology; D011618:Psychotic Disorders / Q000188:drug therapy* / Q000503:physiopathology / Q000523:psychology*; D011930:Reaction Time / Q000187:drug effects; D013028:Space Perception / Q000187:drug effects; D013060:Speech / Q000187:drug effects; D014706:Verbal Learning / Q000187:drug effects / Q000502:physiology
D014150:Antipsychotic Agents