Are perinatal and maternal outcomes different during expectant management of severe preeclampsia in the presence of intrauterine growth restriction?
OBJECTIVE
The purpose of this study was to compare perinatal and maternal outcomes in women with singleton pregnancies and severe preeclampsia (SPE) expectantly managed at 24-33 weeks' gestation (wk) that resulted at birth in severe intrauterine growth restriction (SIUGR, < 5th percentile) to those without SIUGR.


METHODS
Two hundred thirty-nine women undelivered after antenatal steroids were expectantly managed. Perinatal and maternal outcomes were analyzed according to fetal growth status. Students t-test, chi-square test, logistic regression analysis, and odds ratio were calculated.


RESULTS
Fifty-eight pregnancies resulted in an SIUGR neonate. Median latency periods (5 vs 5 d) and delivery gestational ages (30.6 vs 30.3 wk) were similar in the 2 groups. Controlling for gestational age at delivery, only fetal death remained associated with SIUGR (OR: 6.4; 95% CI 1.05-39.35, P = .04). Maternal outcomes were similar in the 2 groups.


CONCLUSIONS
In severe preeclamptic women at 24-33 weeks, SIUGR is associated with increased risk of fetal death but does not affect maternal complications.
Haddad
Bassam
B
Department of Obstetrics and Gynecology, University of Paris XII, Créteil, Paris, France. bhaddad@chicreteil.fr
Kayem
Gilles
G
Deis
Stephanie
S
Sibai
Baha M
BM
D000328:Adult; D005260:Female; D005313:Fetal Death; D005317:Fetal Growth Retardation; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000453:epidemiology; D008875:Middle Aged; D011225:Pre-Eclampsia / Q000628:therapy*; D011247:Pregnancy; D011256:Pregnancy Outcome; D012720:Severity of Illness Index