[Contribution to the clinical study of renal haemodynamic changes due to histamine: considerations on some pathogenetical stages of shock].
This investigation was undertake to study some of the renal haemodynamic changes produced by istamine in the man. Experiments were carried out on ten adult subjects and histamine (20 gamma) was injected intravenously. The diuresis, the glomerular filtration and the plasmatic kidney output decrease during the fifteen minutes succeeding the injection and the recovery was complete thirty minutes after histamine. Because no changes in heart rate and blood pressure were observed after the histamine injection the renal vasocostriction may perhaps act initially to antagonize the hipotensive effects of this drug.
Perini
A
A
Istituto di Clinica Medica Generale dell'Università di Milano.
Capelli
F
F
Bozzi
G
G
D000328:Adult; D000368:Aged; D004231:Diuresis / Q000187:drug effects*; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects*; D006632:Histamine / Q000494:pharmacology*; D018494:Histamine Agents / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012079:Renal Circulation / Q000187:drug effects*; D012769:Shock / Q000188:drug therapy* / Q000503:physiopathology*
D018494:Histamine Agents; D006632:Histamine