Expression of chicken interleukin-2 by turkey herpesvirus increases the immune response against Marek's disease virus but fails to increase protection against virulent challenge.
As Marek's disease virus continues to evolve towards greater virulence, more efficacious vaccines will be required in the future. We expressed chicken interleukin-2 (IL-2) from a turkey herpesvirus (HVT) in an attempt to increase the efficacy of HVT as a vaccine against Marek's disease. The recombinant IL-2/HVT was safe for in ovo vaccination, although it replicated less in the birds compared with the parent HVT strain. Expression of IL-2 increased the neutralizing antibody response against HVT but did not increase the protection against virulent Marek's disease virus challenge.
Tarpey
I
I
Intervet UK, Walton Manor, Walton, Milton Keynes, Bucks, MK7 7AJ, UK. ian.tarpey@intervet.com
Davis
P J
PJ
Sondermeijer
P
P
van Geffen
C
C
Verstegen
I
I
Schijns
V E J C
VE
Kolodsick
Jill
J
Sundick
R
R
D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D002642:Chick Embryo; D002645:Chickens / Q000235:genetics*; D015870:Gene Expression; D026002:Herpesvirus 1, Meleagrid / Q000235:genetics*; D007376:Interleukin-2 / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D025922:Mardivirus / Q000276:immunology / Q000472:pathogenicity*; D008380:Marek Disease / Q000276:immunology* / Q000517:prevention & control / Q000821:virology; D011201:Poultry Diseases / Q000276:immunology / Q000517:prevention & control / Q000821:virology; D014765:Viral Vaccines / Q000009:adverse effects / Q000276:immunology*; D014774:Virulence; D015430:Weight Gain
D000914:Antibodies, Viral; D007376:Interleukin-2; D014765:Viral Vaccines