title: Melanoma inhibiting activity protein (MIA), beta-2 microglobulin and lactate dehydrogenase (LDH) in metastatic melanoma.
abstract: BACKGROUND
  Serum levels of melanoma markers may have a role in monitoring disease evolution in metastatic melanoma.
  
  
  METHODS
  Serial measurements of melanoma inhibiting activity protein (MIA), lactate dehydrogenase (LDH), S-100 and beta2-microglubulin were obtained from 42 metastatic melanoma patients during their biochemotherapy treatment.
  
  
  RESULTS
  High pre-treatment serum levels of S-100, LDH, MIA and P2-microglobulin were detected in 50%, 57%, 50% and 24% of the patients, respectively. Only S-100 had prognostic significance for both disease-free (p=0.011) and overall survival (p=0.021). In patients who responded to treatment, S-100 levels decreased significantly from pre-treatment to the time of response (p = 0.050). When patients progressed, levels of MIA and P2-microglobulin increased significantly (p =0.028 and p =0.030, respectively).
  
  
  CONCLUSIONS
  Correlation with disease evolution was found for S-100, MIA and P2-microglobulin levels. Despite the small sample size of the study, S-100 was a significant prognostic marker for overall survival and disease-free survival.
authors.affiliation: Medical Oncology Department, Institut Clinic de Malaties Hematologiques i Oncològiques (ICMHO). mgocao@gmail.com
authors.forename: M González
authors.initials: MG
authors.lastname: Cao
authors.forename: J M
authors.initials: JM
authors.lastname: Auge
authors.forename: R
authors.initials: R
authors.lastname: Molina
authors.forename: R
authors.initials: R
authors.lastname: Martí
authors.forename: C
authors.initials: C
authors.lastname: Carrera
authors.forename: T
authors.initials: T
authors.lastname: Castel
authors.forename: R
authors.initials: R
authors.lastname: Vilella
authors.forename: C
authors.initials: C
authors.lastname: Conill
authors.forename: M
authors.initials: M
authors.lastname: Sánchez
authors.forename: J
authors.initials: J
authors.lastname: Malvehy
authors.forename: S
authors.initials: S
authors.lastname: Puig
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood; D018450:Disease Progression; D016326:Extracellular Matrix Proteins / Q000097:blood*; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D007770:L-Lactate Dehydrogenase / Q000097:blood*; D008297:Male; D008545:Melanoma / Q000097:blood / Q000473:pathology*; D008875:Middle Aged; D015999:Multivariate Analysis; D009362:Neoplasm Metastasis; D009363:Neoplasm Proteins / Q000097:blood*; D011379:Prognosis; D009418:S100 Proteins / Q000097:blood; D001613:beta 2-Microglobulin / Q000097:blood*
chemical_list: D014408:Biomarkers, Tumor; D016326:Extracellular Matrix Proteins; C090059:MIA protein, human; D009363:Neoplasm Proteins; D009418:S100 Proteins; D001613:beta 2-Microglobulin; D007770:L-Lactate Dehydrogenase