title: [mRNA-transfected dendritic cells: a promising strategy in immunotherapy].
abstract: Dendritic cells play a central role in the initiation of the immune response as they are the only antigen-presenting cells able to prime naive T cells. This makes the dendritic cells the vector of choice to use as a cell-based vaccine in immunotherapy. Although there are several strategies to deliver antigen to dendritic cells, the ones transfected with mRNA coding for tumor or viral antigens are able to induce potent antigen specific T-cell responses directed against multiple epitopes. In this review, we report several advances made in the field of anti-tumoral and anti-HIV immunotherapy using mRNA-transfected dendritic cells-based approaches.
authors.affiliation: Laboratoire d'Immunologie, Centre de Recherche du CHUM Saint-Luc, Montréal, Québec, Canada. k.maisnier-patin@umontreal.ca
authors.forename: Karine
authors.initials: K
authors.lastname: Maisnier-Patin
authors.forename: Sandrine
authors.initials: S
authors.lastname: Crabé
authors.forename: Gaëlle
authors.initials: G
authors.lastname: Breton
authors.forename: Franck P
authors.initials: FP
authors.lastname: Dupuy
authors.forename: Bader
authors.initials: B
authors.lastname: Yassine-Diab
authors.forename: Rafick-Pierre
authors.initials: RP
authors.lastname: Sékaly
mesh_terms: D000818:Animals; D017951:Antigen Presentation; D015703:Antigens, CD / Q000032:analysis; D000951:Antigens, Neoplasm / Q000235:genetics; D000956:Antigens, Viral / Q000235:genetics; D002478:Cells, Cultured / Q000276:immunology / Q000378:metabolism; D017321:Clinical Trials, Phase I as Topic; D003713:Dendritic Cells / Q000145:classification / Q000166:cytology / Q000276:immunology* / Q000378:metabolism; D015658:HIV Infections / Q000628:therapy; D006801:Humans; D016233:Immunotherapy, Active; D008213:Lymphocyte Activation; D051379:Mice; D022423:Myeloid Cells / Q000166:cytology; D009369:Neoplasms / Q000628:therapy; D012333:RNA, Messenger / Q000235:genetics*; D012334:RNA, Neoplasm / Q000235:genetics; D012367:RNA, Viral / Q000235:genetics; D013601:T-Lymphocytes / Q000276:immunology; D014162:Transfection
chemical_list: D015703:Antigens, CD; D000951:Antigens, Neoplasm; D000956:Antigens, Viral; D012333:RNA, Messenger; D012334:RNA, Neoplasm; D012367:RNA, Viral