title: Vascular risk factors and intensity of cognitive dysfunction in MCI.
abstract: Patients with Mild Cognitive Impairment (MCI) have a greater risk of developing dementia than general population. Lots of evidence suggests that cardiovascular risk factors appear more often in the MCI than in general population The aim of this study was to evaluate association between cardiovascular risk factors and intensity of cognitive impairment in MCI patients. We evaluated 24 MCI patients (9 women and 15 men) fulfilling Mayo Clinic Group Criteria. Taking under consideration presence of cardiovascular diseases patients were divided into two groups: first group (n=16) MCI with cardiovascular diseases and second group (n=8) MCI without cardiovascular disorders. Cognitive functions were assessed by neuropsychological tests battery including MMSE, Clock Drawing Test, Trail Making Test (TMT), Verbal Fluency Test with letters FAS, Auditory Verbal Learning Test (AVLT). In the MCI group with vascular risk factors we have found more distinct dysfunction of learning new information, recall and short-term memory than in MCI patients without vascular pathology. In conclusion we may suggest that more distinct cognitive deficit may indicate higher risk of developing dementia, that is why patients with MCI should be under special supervision, with at least annual neuropsychological evaluation.
authors.affiliation: Department of Neurology, Aging, Vascular and Neurodegenerative Diseases, Silesian Medical University, Central University Hospital, ul. Medyków 14, 40-752 Katowice, Poland. neurowp@slam.katowice.pl
authors.forename: Joanna
authors.initials: J
authors.lastname: Siuda
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Gorzkowska
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Opala
authors.forename: Stanisław
authors.initials: S
authors.lastname: Ochudło
mesh_terms: D000368:Aged; D002561:Cerebrovascular Disorders / Q000453:epidemiology / Q000503:physiopathology / Q000523:psychology; D003072:Cognition Disorders / Q000175:diagnosis / Q000453:epidemiology* / Q000503:physiopathology; D015897:Comorbidity / Q000639:trends; D003324:Coronary Artery Disease / Q000453:epidemiology / Q000503:physiopathology / Q000523:psychology; D003704:Dementia / Q000175:diagnosis / Q000453:epidemiology* / Q000503:physiopathology; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000453:epidemiology / Q000503:physiopathology / Q000523:psychology; D006973:Hypertension / Q000453:epidemiology / Q000503:physiopathology / Q000523:psychology; D008297:Male; D008569:Memory Disorders / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology; D009483:Neuropsychological Tests; D011237:Predictive Value of Tests; D011379:Prognosis; D012307:Risk Factors; D012907:Smoking / Q000453:epidemiology; D014652:Vascular Diseases / Q000453:epidemiology* / Q000503:physiopathology / Q000523:psychology*