Increased striatal gray matter densities in patients with schizophrenia and substance use disorder: a voxel-based morphometry study.
We sought to investigate the link between substance abuse and increased striatal gray matter densities (GMD) in schizophrenia, using voxel-based morphometry (VBM). Increased striatal GMD were found in patients with schizophrenia and substance use disorder (n=12), but not schizophrenia only patients (n=11), compared to healthy volunteers (n=15).
Potvin
Stéphane
S
Department of Psychiatry, Fernand-Seguin Research Center, University of Montreal, Canada.
Mancini-Marïe
Adham
A
Fahim
Chérine
C
Mensour
Boualem
B
Lévesque
Johanne
J
Karama
Sherif
S
Beauregard
Mario
M
Rompré
Pierre-Paul
PP
Stip
Emmanuel
E
D000328:Adult; D014150:Antipsychotic Agents / Q000494:pharmacology / Q000627:therapeutic use; D002452:Cell Count; D003342:Corpus Striatum / Q000187:drug effects / Q000473:pathology*; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D006220:Haloperidol / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D017448:Receptors, Dopamine D2 / Q000187:drug effects; D012559:Schizophrenia / Q000188:drug therapy / Q000453:epidemiology / Q000473:pathology; D012720:Severity of Illness Index; D019966:Substance-Related Disorders / Q000175:diagnosis / Q000453:epidemiology*
D014150:Antipsychotic Agents; D017448:Receptors, Dopamine D2; D006220:Haloperidol