Artemisinins inhibit Trypanosoma cruzi and Trypanosoma brucei rhodesiense in vitro growth.
Artemisinin compounds inhibit in vitro growth of cultured Trypanosoma cruzi and Trypanosoma brucei rhodesiense at concentrations in the low micromolar range. Artemisinin also inhibits calcium-dependent ATPase activity in T. cruzi membranes, suggesting a mode of action via membrane pumps. Artemisinins merit further investigation as chemotherapeutic options for these pathogens.
Mishina
Yuliya V
YV
Department of Microbiology, University of Mississippi Medical Center, Jackson, MI 39216, USA.
Krishna
Sanjeev
S
Haynes
Richard K
RK
Meade
John C
JC
D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology*; D037621:Artemisinins / Q000494:pharmacology*; D000252:Calcium-Transporting ATPases / Q000037:antagonists & inhibitors; D021261:Parasitic Sensitivity Tests; D012717:Sesquiterpenes / Q000494:pharmacology*; D016833:Trypanosoma brucei rhodesiense / Q000187:drug effects* / Q000254:growth & development; D014349:Trypanosoma cruzi / Q000187:drug effects* / Q000254:growth & development
D000890:Anti-Infective Agents; D037621:Artemisinins; D012717:Sesquiterpenes; C031327:artemisinin; D000252:Calcium-Transporting ATPases