Fully automated flow-through synthesis of secondary sulfonamides in a binary reactor system.
A fully automated flow-through process for the production of secondary sulfonamides is presented. Primary sulfonamides were monoalkylated using a two-step "catch and release" protocol to generate library products of high purity. The automated flow synthesis platform incorporates four independent reactor columns and is able to perform automated column regeneration. A 48-member sulfonamide library was prepared as two 24-member sublibraries, affording library compounds in good yields and high purities without the need for further column chromatographic purification.
Griffiths-Jones
Charlotte M
CM
GlaxoSmithKline Cambridge Technology Centre, University Chemical Laboratory, Lensfield Road, Cambridge, CB2 1EW, UK.
Hopkin
Mark D
MD
Jönsson
Daniel
D
Ley
Steven V
SV
Tapolczay
David J
DJ
Vickerstaffe
Emma
E
Ladlow
Mark
M
D020650:Combinatorial Chemistry Techniques / Q000295:instrumentation / Q000379:methods*; D015394:Molecular Structure; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000737:chemistry; D013997:Time Factors
D013449:Sulfonamides