Differentiation of human keratinocytes requires the vitamin d receptor and its coactivators.
1,25-Dihydroxyvitamin D3 exerts its effects by binding to the vitamin D receptor (VDR), which regulates transcription of target genes by recruiting various coactivators. Bikle and colleagues examined the role of several coactivators in human epidermal keratinocytes and found that, although these coactivators differentially associate with the VDR in proliferating versus differentiating keratinocytes, each is required for both early and late differentiation.
Bollag
Wendy B
WB
Institute of Molecular Medicine and Genetics, Department of Medicine (Dermatology), Medical College of Georgia, Augusta, Georgia 30912, USA. wbollag@mcg.edu
D002454:Cell Differentiation / Q000502:physiology*; D006801:Humans; D015603:Keratinocytes / Q000166:cytology*; D018167:Receptors, Calcitriol / Q000502:physiology*
D018167:Receptors, Calcitriol