title: Expression of CCR5 in graft-versus-host disease (GVHD) of the skin: immunohistochemical staining of 38 cases.
abstract: To ascertain the involvement of CCR5 in prolongation of graft-versus-host disease (GVHD), we performed immunohistochemical staining of CCR5 in 38 GVHD samples (23 acute and 15 chronic). A total of seven out of 15 cases of chronic GVHD were positive for CCR5; however, only two out of 23 in acute GVHD were positive for CCR5. In three cases, expression of CCR5 in infiltrating lymphocytes was negative in the acute phase, but positive in the chronic phase of GVHD. These findings suggest that the immunopathological mechanism that differentiates between acute and chronic GVHD is a CCR5-mediated immunoreaction.
authors.affiliation: Department of Dermatology, Graduate School of Medicine, Kyoto University, Sakyo-ku, Kyoto, Japan. naoino@kuhp.kyoto-u.ac.jp
authors.forename: Naoko I
authors.initials: NI
authors.lastname: Morita
authors.forename: Yumi
authors.initials: Y
authors.lastname: Matsumura
authors.forename: Kazumasa
authors.initials: K
authors.lastname: Morita
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Miyachi
mesh_terms: D000208:Acute Disease; D002908:Chronic Disease; D006086:Graft vs Host Disease / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D019713:Receptors, CCR5 / Q000378:metabolism*; D012867:Skin / Q000378:metabolism*
chemical_list: D019713:Receptors, CCR5