Pig-to-non-human primate heart transplantation: immunologic progress over 20 years.
The major developments in pig-to-non-human primate heart xenotransplantation during the past 20 years are summarized, largely through the experience of one investigator. Genetic modifications to organ-source pigs have been important steps in increasing heart xenograft survival from a few minutes in 1986 to 2 to 6 months in 2005.
Zhu
Xiaocheng
X
Thomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA.
Dor
Frank J M F
FJ
Cooper
David K C
DK
D000818:Animals; D016027:Heart Transplantation / Q000266:history / Q000276:immunology* / Q000639:trends; D049673:History, 20th Century; D049674:History, 21st Century; D011323:Primates; D013552:Swine; D014181:Transplantation Immunology; D014183:Transplantation, Heterologous / Q000266:history / Q000276:immunology* / Q000639:trends