title: Clinical study on safety of adult-to-adult living donor liver transplantation in both donors and recipients.
abstract: OBJECTIVE
  To investigate the safety of adult-to-adult living donor liver transplantation (A-A LDLT) in both donors and recipients.
  
  
  METHODS
  From January 2002 to July 2006, 50 cases of A-A LDLT were performed at West China Hospital, Sichuan University, consisting of 47 cases using right lobe graft without middle hepatic vein (MHV), and 3 cases using dual grafts (one case using two left lobe, 2 using one right lobe and one left lobe). The most common diagnoses were hepatitis B liver cirrosis, 30 (60%) cases; and hepatocellular carcinoma, 15 (30%) cases in adult recipients. Among them, 10 cases had the model of end-stage liver disease (MELD) with a score of more than 25. Donor screening consisted of reconstruction of the hepatic blood vessels and biliary system with 3-dimension computed tomography and volumetry of whole liver and right liver volume. Various improved surgical techniques were adopted in the procedures for both donors and recipients.
  
  
  RESULTS
  Forty-nine right lobes and 3 left lobes (2 left lobe grafts for 1 recipient, 1 left lobe graft for 1 recipient who had received right lobe graft donated by relative living donor) were obtained from 52 living donors. The 49 right lobe grafts, without MHV, weighed 400 g-850 g (media 550 g), and the ratio of graft volume to recipient standard liver volume (GV/SLV) ranged from 31.74% to 71.68% (mean 45.35%). All donors' remnant liver volume was over 35% of the whole liver volume. There was no donor mortality. With a follow-up of 2-52 mo (media 9 mo), among 50 adult recipients, complications occurred in 13 (26%) cases and 4 (8%) died postoperatively within 3 mo. Their 1-year actual survival rate was 92%.
  
  
  CONCLUSIONS
  When preoperative CT volumetry shows volume of remnant liver is more than 35%, the ratio of right lobe graft to recipients standard liver volume exceeding 40%, A-A LDLT using right lobe graft without MHV should be a very safe procedure for both donors and recipients, otherwise dual grafts liver transplantation should be considered.
authors.affiliation: Liver Transplantation Division, Department of Surgery, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Liu
authors.forename: Lu-Nan
authors.initials: LN
authors.lastname: Yan
authors.forename: Wen-Tao
authors.initials: WT
authors.lastname: Wang
authors.forename: Bo
authors.initials: B
authors.lastname: Li
authors.forename: Yong
authors.initials: Y
authors.lastname: Zeng
authors.forename: Tian-Fu
authors.initials: TF
authors.lastname: Wen
authors.forename: Ming-Qing
authors.initials: MQ
authors.lastname: Xu
authors.forename: Jia-Yin
authors.initials: JY
authors.lastname: Yang
authors.forename: Zhe-Yu
authors.initials: ZY
authors.lastname: Chen
authors.forename: Ji-Chun
authors.initials: JC
authors.lastname: Zhao
authors.forename: Yu-Kui
authors.initials: YK
authors.lastname: Ma
authors.forename: Jiang-Wen
authors.initials: JW
authors.lastname: Liu
authors.forename: Hong
authors.initials: H
authors.lastname: Wu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000601:surgery; D002648:Child; D005260:Female; D006085:Graft Survival; D006509:Hepatitis B / Q000601:surgery; D006801:Humans; D008099:Liver / Q000000981:diagnostic imaging / Q000473:pathology; D008103:Liver Cirrhosis / Q000601:surgery; D008107:Liver Diseases / Q000601:surgery; D008113:Liver Neoplasms / Q000601:surgery; D016031:Liver Transplantation / Q000009:adverse effects* / Q000401:mortality; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed; D014180:Transplantation