title: Plasmodium vivax: genetic diversity of the apical membrane antigen-1 (AMA-1) in isolates from India.
abstract: Malaria parasites exhibit sequence diversity for a number of stage specific antigens. Several studies have proved that apical membrane antigen-1 (AMA-1) is an effective target for eliciting a protective immune response in humans and other experimental animals. We have investigated the sequence variation in Plasmodium vivax AMA-1 (Pv AMA-1) from different Indian isolates. This is the first study of its kind for the nearly full length Pv AMA-1 from India. Our analysis reveals greater degree of genetic diversity in Pv AMA-1 than reported so far and identifies five novel haplotypes. This is significant to establish the antigenic repertoire of isolates in a malaria endemic country like India.
authors.affiliation: Department of Biological Sciences, Birla Institute of Technology and Science, Pilani, Rajasthan, India.
authors.forename: Vidya
authors.initials: V
authors.lastname: Rajesh
authors.forename: M
authors.initials: M
authors.lastname: Elamaran
authors.forename: S
authors.initials: S
authors.lastname: Vidya
authors.forename: M
authors.initials: M
authors.lastname: Gowrishankar
authors.forename: Dhanpat
authors.initials: D
authors.lastname: Kochar
authors.forename: Ashis
authors.initials: A
authors.lastname: Das
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000953:Antigens, Protozoan / Q000737:chemistry / Q000235:genetics* / Q000276:immunology; D000954:Antigens, Surface / Q000737:chemistry / Q000235:genetics / Q000276:immunology; D001483:Base Sequence; D017124:Conserved Sequence; D003545:Cysteine / Q000737:chemistry; D016054:DNA, Protozoan / Q000737:chemistry*; D014644:Genetic Variation; D006239:Haplotypes; D006801:Humans; D007194:India / Q000453:epidemiology; D017780:Malaria Vaccines / Q000235:genetics; D016780:Malaria, Vivax / Q000453:epidemiology / Q000469:parasitology; D008565:Membrane Proteins / Q000737:chemistry / Q000235:genetics* / Q000276:immunology; D008969:Molecular Sequence Data; D010966:Plasmodium vivax / Q000235:genetics* / Q000276:immunology*; D017354:Point Mutation; D011110:Polymorphism, Genetic; D015800:Protozoan Proteins / Q000737:chemistry / Q000235:genetics* / Q000276:immunology; D016415:Sequence Alignment
chemical_list: D000953:Antigens, Protozoan; D000954:Antigens, Surface; D016054:DNA, Protozoan; D017780:Malaria Vaccines; D008565:Membrane Proteins; D015800:Protozoan Proteins; C090077:apical membrane antigen I, Plasmodium; D003545:Cysteine