Relationship between diet and anticoagulant response to warfarin: a factor analysis.
BACKGROUND
Diet composition is one of the factors that may contribute to intraindividual variability in the anticoagulant response to warfarin.


OBJECTIVE
To determine the associations between food pattern and anticoagulant response to warfarin in a group of Brazilian patients with vascular disease.


METHODS
Recent and usual food intakes were assessed in 115 patients receiving warfarin; and corresponding plasma phylloquinone (vitamin K(1)), serum triglyceride concentrations, prothrombin time (PT), and International Normalized Ratio (INR) were determined. A factor analysis was used to examine the association of specific foods and biochemical variables with anticoagulant data.


RESULTS
Mean age was 59 +/- 15 years. Inadequate anticoagulation, defined as values of INR 2 or 3, was found in 48% of the patients. Soybean oil and kidney beans were the primary food sources of phylloquinone intake. Factor analysis yielded four separate factors, explaining 56.4% of the total variance in the data set. The factor analysis revealed that intakes of kidney beans and soybean oil, 24-h recall of phylloquinone intake, PT and INR loaded significantly on factor 1. Triglycerides, PT, INR, plasma phylloquinone, and duration of anticoagulation therapy loaded on factor 3.


CONCLUSIONS
Fluctuations in phylloquinone intake, particularly from kidney beans, and plasma phylloquinone concentrations were associated with variation in measures of anticoagulation (PT and INR) in a Brazilian group of patients with vascular disease.
Custódio das Dôres
Silvia Maria
SM
Depto. de Nutrição e Dietética da Faculdade de Nutrição, Universidade Federal Fluminense (UFF), Rua São Paulo, 30/4 andar. Centro, Niterói, RJ 24015-110, Brazil. silviam@vm.uff.br
Booth
Sarah L
SL
Martini
Ligia Araújo
LA
Aújo Martini
Ligia
L
de Carvalho Gouvêa
Victor Hugo
VH
Padovani
Carlos Roberto
CR
de Abreu Maffei
Francisco Humberto
FH
Campana
Alvaro Oscar
AO
Rupp de Paiva
Sérgio Alberto
SA
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000925:Anticoagulants / Q000494:pharmacology*; D000933:Antifibrinolytic Agents / Q000008:administration & dosage / Q000097:blood; D001777:Blood Coagulation / Q000187:drug effects* / Q000502:physiology; D004032:Diet; D005163:Factor Analysis, Statistical; D005260:Female; D006801:Humans; D019934:International Normalized Ratio; D008297:Male; D008875:Middle Aged; D011517:Prothrombin Time; D011795:Surveys and Questionnaires; D014280:Triglycerides / Q000097:blood; D014652:Vascular Diseases / Q000097:blood / Q000188:drug therapy; D010837:Vitamin K 1 / Q000008:administration & dosage / Q000097:blood; D014859:Warfarin / Q000494:pharmacology*
D000925:Anticoagulants; D000933:Antifibrinolytic Agents; D014280:Triglycerides; D014859:Warfarin; D010837:Vitamin K 1