title: Abdominal computed tomography predicts progression in patients with Rai stage 0 chronic lymphocytic leukemia.
abstract: OBJECTIVE
  Whether computed tomography (CT) should be routinely included in the diagnostic work-up in patients with chronic lymphocytic leukemia (CLL) has not yet been determined. The aim of this study was to analyze the prognostic significance of abdominal CT in patients with CLL in Rai clinical stage 0.
  
  
  METHODS
  Abdominal CT was performed at diagnosis in 140 patients consecutively diagnosed with CLL in Rai stage 0 disease.
  
  
  RESULTS
  An abnormal abdominal CT was found in 38 patients (27%). Abnormal CT correlated with increased bone marrow infiltration (P = .024), high lymphocyte count (P = .001), increased ZAP-70 expression (P = .003), and short lymphocyte doubling time (LDT; P = .007). Patients with abnormal CT progressed more frequently and had a shorter time to progression than those with normal CT (median, 3.5 years v not reached, respectively; P < .001) and required earlier treatment intervention. In a multivariate analysis, only high ZAP-70 expression (relative risk = 3.60) and an abnormal abdominal CT (RR = 2.71) correlated with disease progression.
  
  
  CONCLUSIONS
  In this series, an abnormal abdominal CT was a strong predictor of progression in patients with early-stage CLL. The inclusion of CT scans in the initial work-up of patients with early clinical stage on clinical grounds can, therefore, provide relevant clinical information.
authors.affiliation: Department of Hematology, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic, University of Barcelona, Barcelona, Spain.
authors.forename: Ana
authors.initials: A
authors.lastname: Muntañola
authors.forename: Francesc
authors.initials: F
authors.lastname: Bosch
authors.forename: Pedro
authors.initials: P
authors.lastname: Arguis
authors.forename: Eduardo
authors.initials: E
authors.lastname: Arellano-Rodrigo
authors.forename: Carmen
authors.initials: C
authors.lastname: Ayuso
authors.forename: Eva
authors.initials: E
authors.lastname: Giné
authors.forename: Marta
authors.initials: M
authors.lastname: Crespo
authors.forename: Pau
authors.initials: P
authors.lastname: Abrisqueta
authors.forename: Carol
authors.initials: C
authors.lastname: Moreno
authors.forename: Francesc
authors.initials: F
authors.lastname: Cobo
authors.forename: Armando
authors.initials: A
authors.lastname: López-Guillermo
authors.forename: Emili
authors.initials: E
authors.lastname: Montserrat
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D018450:Disease Progression; D005260:Female; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000000981:diagnostic imaging* / Q000401:mortality*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D011336:Probability; D011379:Prognosis; D016016:Proportional Hazards Models; D011860:Radiography, Abdominal / Q000379:methods; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D012737:Sex Factors; D018709:Statistics, Nonparametric; D016019:Survival Analysis; D014057:Tomography, X-Ray Computed / Q000379:methods*