title: Construction and validation of mean shape atlas templates for atlas-based brain image segmentation.
abstract: In this paper, we evaluate different schemes for constructing a mean shape anatomical atlas for atlas-based segmentation of MR brain images. Each atlas is constructed and validated using a database of 20 images for which detailed manual delineations of 49 different subcortical structures are available. Atlas construction and atlas based segmentation are performed by non-rigid intensity-based registration using a viscous fluid deformation model with parameters that were optimally tuned for this particular task. The segmentation performance of each atlas scheme is evaluated on the same database using a leave-one-out approach and measured by the volume overlap of corresponding regions in the ground-truth manual segmentation and the warped atlas label image.
authors.affiliation: Katholieke Universiteit Leuven, Faculties of Medicine and Engineering, Medical Image Computing - ESAT/PSI, University Hospital Gasthuisberg, Herestraat 49, B-3000 Leuven, Belgium. Qian.Wang@uz.kuleuven.ac.be
authors.forename: Qian
authors.initials: Q
authors.lastname: Wang
authors.forename: Dieter
authors.initials: D
authors.lastname: Seghers
authors.forename: Emiliano
authors.initials: E
authors.lastname: D'Agostino
authors.forename: Frederik
authors.initials: F
authors.lastname: Maes
authors.forename: Dirk
authors.initials: D
authors.lastname: Vandermeulen
authors.forename: Paul
authors.initials: P
authors.lastname: Suetens
authors.forename: Alexander
authors.initials: A
authors.lastname: Hammers
mesh_terms: D000328:Adult; D000465:Algorithms; D000716:Anatomy, Artistic / Q000379:methods; D001185:Artificial Intelligence; D001921:Brain / Q000033:anatomy & histology*; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D016247:Information Storage and Retrieval / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008488:Medical Illustration; D010363:Pattern Recognition, Automated / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013382:Subtraction Technique