A case of lymphoepithelioma-like carcinoma of the colon with ulcerative colitis.
Follow-up colonoscopy of a 25-year-old Japanese man with ulcerative colitis (UC) who had undergone endoscopic mucosal resection twice for early colon cancers revealed the presence of a new 1.5-cm-diameter tumor in the sigmoid colon. It was diagnosed by preoperative biopsy as a poorly differentiated adenocarcinoma. Sigmoidectomy was performed, and the pathological findings revealed lymphoepithelioma-like carcinoma (LEC). In situ hybridization to detect Epstein-Barr virus (EBV)-encoded small RNAs showed positive signals in stromal lymphocytes, but weak signals in the tumor cells. The association between EBV and LEC was obscure in this case. Unlike typical UC-mediated colon cancers, the lesion was poorly differentiated, and negative for p53 signals immunohistochemically. These findings may hint at a novel mechanism of carcinogenesis in UC-mediated colorectal cancer.
Kojima
Yasuyuki
Y
Department of Surgery, Yokosuka Kyosai Hospital, 1-16 Yonegahama, Yokosuka, Kanagawa, Japan.
Mogaki
Masatoshi
M
Takagawa
Ryo
R
Ota
Ikuko
I
Sugita
Mitsutaka
M
Natori
Shiho
S
Hamaguchi
Yohei
Y
Kurosawa
Haruki
H
Fukushima
Tadao
T
Masui
Hidenobu
H
Fukazawa
Shingo
S
Yamanaka
Shoji
S
Tsuura
Yukio
Y
Nagahori
Kaoru
K
D000328:Adult; D002277:Carcinoma / Q000150:complications* / Q000473:pathology; D003093:Colitis, Ulcerative / Q000150:complications* / Q000473:pathology; D003110:Colonic Neoplasms / Q000150:complications* / Q000473:pathology; D006801:Humans; D008297:Male