title: In vitro efficiency of new acridyl derivatives against Plasmodium falciparum.
abstract: A series of new 9-substituted acridyl derivatives were synthesized and their in vitro antimalarial activity was evaluated against one chloroquine-sensitive strain (3D7) and three chloroquine-resistant strains [W2 (Indochina), Bre1 (Brazil) and FCR3 (Gambia)] of Plasmodium falciparum. Some compounds inhibit the growth of malarial parasite with IC50 <or= 0.20 microM.
authors.affiliation: Equipe de Chimie Bioorganique et Bioinorganique, Institut de Chimie Moléculaire et des Matériaux d'Orsay, Bât. 420, CNRS UMR 8182, Univ Paris-Sud, 91405 Orsay Cedex, France.
authors.forename: Lucie
authors.initials: L
authors.lastname: Guetzoyan
authors.forename: Florence
authors.initials: F
authors.lastname: Ramiandrasoa
authors.forename: Hélène
authors.initials: H
authors.lastname: Dorizon
authors.forename: Christine
authors.initials: C
authors.lastname: Desprez
authors.forename: Alexandre
authors.initials: A
authors.lastname: Bridoux
authors.forename: Christophe
authors.initials: C
authors.lastname: Rogier
authors.forename: Bruno
authors.initials: B
authors.lastname: Pradines
authors.forename: Martine
authors.initials: M
authors.lastname: Perrée-Fauvet
mesh_terms: D000166:Acridines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D000962:Antimalarials / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D021261:Parasitic Sensitivity Tests; D010963:Plasmodium falciparum / Q000187:drug effects* / Q000254:growth & development; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D000166:Acridines; D000962:Antimalarials