Evaluation of insulin-like growth factor-1 in a mouse model of long-term abdominal radiation toxicity.
The purpose of these experiments was to test whether a brief course of insulin-like growth factor-1 (IGF-1) injection (escalating doses) concomitant to irradiation ameliorates radiation-induced kidney dysfunction and lethal bowel toxicity in a mouse model of unilateral high-dose irradiation of the kidney and adjacent bowel. The kidney function was assessed by means of repeated 99mTc-dimercaptosuccinate scans (every six weeks) during a maximum follow-up of 49 weeks. The experiments with single fractions of 12 Gy and 15 Gy revealed only minor differences in the severity of kidney dysfunction and no reduction in lethal bowel toxicity from IGF-1 treatment In the absence of any significant radioprotective effect, other strategies of response modification need to be developed.
Nieder
Carsten
C
Department of Radiation Oncology, Klinikum rechts der Isar der Technischen Universität München, Munich, Germany. cnied@hotmail.com
Cai
Lu
L
Weber
Wolfgang A
WA
Schill
Sabine
S
Andratschke
Nicolaus
N
Schwaiger
Markus
M
Molls
Michael
M
D000818:Animals; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004307:Dose-Response Relationship, Radiation; D005260:Female; D007334:Insulin-Like Growth Factor I / Q000494:pharmacology*; D007410:Intestinal Diseases / Q000209:etiology / Q000517:prevention & control*; D007422:Intestines / Q000528:radiation effects; D007668:Kidney / Q000000981:diagnostic imaging / Q000528:radiation effects; D007674:Kidney Diseases / Q000000981:diagnostic imaging / Q000209:etiology / Q000517:prevention & control*; D051379:Mice; D008809:Mice, Inbred C3H; D011833:Radiation Injuries, Experimental / Q000000981:diagnostic imaging / Q000517:prevention & control*; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D019783:Technetium Tc 99m Dimercaptosuccinic Acid
D011837:Radiation-Protective Agents; D019275:Radiopharmaceuticals; D019783:Technetium Tc 99m Dimercaptosuccinic Acid; D007334:Insulin-Like Growth Factor I