title: Biphasic malignant mesothelioma cases with osseous differentiation and long survival: a review of the literature.
abstract: This report describes two cases of diffuse biphasic malignant mesothelioma with osseous differentiation and long survival. Two male patients aged 66 and 54 years presented with chest pain, bloody pleural effusions, and diffuse and nodular pleural thickening. They both had a history of prolonged asbestos exposure. Sarcomatoid and epithelioid areas were identified on histopathological examination. In addition, there were foci of ossification. Epithelioid tumor cells as well as benign osteoclasts within the ossification reacted positively for cytokeratin 5/6, whereas sarcomatoid areas were negative. Both patients survived 39 and 69 months, respectively. To our knowledge, these two cases with biphasic malignant mesothelioma and osseous differentiation with long survival are the first to be described from Central Anatolia.
authors.affiliation: Atatürk Chest Diseases and Chest Surgery Education and Research Hospital, Department of Pathology, Ankara, Turkey.
authors.forename: Funda
authors.initials: F
authors.lastname: Demirag
authors.forename: Ebru
authors.initials: E
authors.lastname: Unsal
authors.forename: Irfan
authors.initials: I
authors.lastname: Tastepe
mesh_terms: D000368:Aged; D001195:Asbestosis / Q000150:complications / Q000473:pathology; D014408:Biomarkers, Tumor / Q000378:metabolism; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D053555:Keratin-5 / Q000378:metabolism; D053553:Keratin-6 / Q000378:metabolism; D008297:Male; D008654:Mesothelioma / Q000737:chemistry / Q000000981:diagnostic imaging / Q000209:etiology / Q000378:metabolism / Q000473:pathology*; D008875:Middle Aged; D009999:Ossification, Heterotopic; D010010:Osteoclasts / Q000378:metabolism; D010997:Pleural Neoplasms / Q000737:chemistry / Q000000981:diagnostic imaging / Q000209:etiology / Q000378:metabolism / Q000473:pathology*; D016019:Survival Analysis; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D000951:Antigens, Neoplasm
chemical_list: D014408:Biomarkers, Tumor; D053555:Keratin-5; D053553:Keratin-6; C432845:HBME-1 antigen; D000951:Antigens, Neoplasm