title: Airborne Alternaria spores: Potential allergic sensitizers in Saudi Arabia.
abstract: BACKGROUND
  In order to investigate the role of airborne Alternaria spp. in the sensitization of individuals having respiratory allergy symptoms, particularly bronchial asthma, an aerobiologic and clinical (diagnostic) study was conducted at several centers in Saudi Arabia.
  
  
  METHODS
  Airborne Alternaria spores were studied at four different centers in Riyadh, Jeddah and Al-Khobar, including three years at one site. Skin prick tests (SPT) were conducted on a total of 616 allergic individuals attending allergy clinics at six different hospitals in Abha, Qassim, Gizan, Jeddah, Hofuf and Makkah regions.
  
  
  RESULTS
  Alternaria spores constituted between 1.9%-9.6% of the total fungal air spora, and the maximum concentration exceeded 5x10 2 spores per m3 of air in Jeddah, followed by 4.9x102 spores per m3 in Al-Khobar. Mean weekly and monthly concentration of Alternaria fluctuated, reaching up to 150 spores per m 3 and 60 spores per m 3, respectively. Quantitative regional variations were also recorded. IgE-mediated SPT reactivities conducted on allergic patients resulted in an overall 21.6% positive reactions, showing mild, moderate and strong wheal and erythema.
  
  
  CONCLUSIONS
  The findings reveal that Alternaria spores are prevalent as a major component in the outdoor environment of the Kingdom, with peaks in April and October. The overall 21.6% positive SPT reactions indicate the sensitization level or cross-reactive sensitivity to Alternaria allergens. The study suggests that airborne Alternaria can be a potential allergic sensitizer in susceptible individuals and can be a risk factor in sensitized individuals with symptoms of bronchial asthma and allergic rhinitis in the Kingdom of Saudi Arabia.
authors.affiliation: Department of Biological and Medical Research, King Faisal Specialist Hospital and Research Centre, and College of Medicine, King Saud University, Riyadh, Saudi Arabia.
authors.forename: S M
authors.initials: SM
authors.lastname: Hasnain
authors.forename: A
authors.initials: A
authors.lastname: Al-Frayh
authors.forename: M O
authors.initials: MO
authors.lastname: Gad-El-Rab
authors.forename: S
authors.initials: S
authors.lastname: Al-Sedairy