Incidence of and risk factors for diabetes mellitus in cats that have undergone renal transplantation: 187 cases (1986-2005).
OBJECTIVE
To compare incidence of diabetes mellitus in cats that had undergone renal transplantation with incidence in cats with chronic renal failure, compare mortality rates in cats that underwent renal transplantation and did or did not develop diabetes mellitus, and identify potential risk factors for development of posttransplantation diabetes mellitus (PTDM) in cats.


METHODS
Retrospective case series.


METHODS
187 cats that underwent renal transplantation.


METHODS
Medical records were reviewed.


RESULTS
26 of the 187 (13.9%) cats developed PTDM, with the incidence of PTDM being 66 cases/1,000 cat years at risk. By contrast, the incidence of diabetes mellitus among a comparison population of 178 cats with chronic renal failure that did not undergo renal transplantation was 17.9 cases/1,000 cat years at risk, and cats that underwent renal trans-plantation were 5.45 times as likely to develop diabetes mellitus as were control cats with chronic renal failure. The mortality rate among cats with PTDM was 2.38 times the rate among cats that underwent renal transplantation but did not develop PTDM. Age, sex, body weight, and percentage change in body weight were not found to be significantly associated with development of PTDM.


CONCLUSIONS
Results suggest that cats that undergo renal transplantation have an increased risk of developing diabetes mellitus, compared with cats with chronic renal failure, and that mortality rate is higher for cats that develop PTDM than for cats that do not.
Case
Joseph B
JB
Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California, Davis, CA 95616, USA.
Kyles
Andrew E
AE
Nelson
Richard W
RW
Aronson
Lillian
L
Kass
Philip H
PH
Klose
Tyler C
TC
Bailiff
Nathan L
NL
Gregory
Clare R
CR
D000818:Animals; D002371:Cat Diseases / Q000453:epidemiology* / Q000209:etiology / Q000401:mortality; D002415:Cats; D003920:Diabetes Mellitus / Q000453:epidemiology / Q000209:etiology / Q000401:mortality / Q000662:veterinary*; D005260:Female; D015994:Incidence; D007676:Kidney Failure, Chronic / Q000150:complications / Q000628:therapy / Q000662:veterinary*; D016030:Kidney Transplantation / Q000009:adverse effects / Q000662:veterinary*; D008297:Male; D011183:Postoperative Complications / Q000453:epidemiology / Q000662:veterinary; D012189:Retrospective Studies; D012307:Risk Factors; D013997:Time Factors