Association of a new SNP in promoter region of the porcine FABP3 gene with fatness traits in a polish synthetic line.
Associations between FABP3 (alternatively named H-FABP) gene polymorphisms and fatness traits were tested in two pig breeds (Polish Large White and Polish Landrace) and one synthetic line - 990. Three known single nucleotide polymorphisms, detected by HinfI, MspI and HaeIII restriction enzymes, were analyzed. Moreover, three new polymorphisms in the 5' regulatory region were identified: C(-221)T, C(-160)G and T(-158)G, but only the third one was widely distributed and correlated with backfat thickness in line 990. The obtained results suggest that the FABP3 gene is linked with an unknown gene directly affecting backfat thickness, but the analyzed polymorphisms do not influence fatness traits.
Chmurzynska
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Department of Animal Genetics and Breeding, August Cieszkowski Agricultural University of Poznan, Poland.
Szydlowski
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Stachowiak
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Stankiewicz
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Switonski
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M
D000273:Adipose Tissue / Q000502:physiology*; D000818:Animals; D001483:Base Sequence; D004247:DNA / Q000737:chemistry / Q000235:genetics; D050556:Fatty Acid-Binding Proteins / Q000235:genetics*; D005260:Female; D005838:Genotype; D008297:Male; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction / Q000662:veterinary; D020641:Polymorphism, Single Nucleotide; D015183:Restriction Mapping; D013552:Swine / Q000235:genetics*
D050556:Fatty Acid-Binding Proteins; D004247:DNA