title: Optical mammography: a new technique for visualizing breast lesions in women presenting non palpable BIRADS 4-5 imaging findings: preliminary results with radiologic-pathologic correlation.
abstract: The purpose of this prospective study is to determine the diagnostic accuracy of near-infrared breast optical absorption imaging in patients with Breast Imaging Reporting and Data System (BIRADS) 4-5 non-palpable lesions scheduled for biopsy, using pathology after core or excisional biopsy as a reference. The patient's breast was positioned onto a panel of red light-emitting diodes (640 nm). A soft membrane was inflated to exert a uniform pressure on the breast. Transmitted light was detected using a CCD camera. The entire acquisition sequence took 1 minute. Image processing generated dynamic images displayed in colour scale, to reveal time-dependent changes in the transmitted light intensity caused by the pressure change. Dynamic curves were classified in two categories: consistently decreasing intensity suspicious for malignancy, and sinusoidal increasing intensity considered as benign. Seventy-eight women consulting for non-palpable breast lesions were initially included in the study. An imaging-histology correlation was obtained for seventy-two patients, the remaining six patients were excluded for technical optical scan reasons. We experienced an overall sensitivity of 73% and specificity of 38%, the false negative results being mainly small size (<10 mm) infiltrating malignant lesions and ductal carcinoma in situ (DCIS). False positive results were seen in benign proliferative lesions. Dynamic optical breast imaging is a novel, low-cost, non-invasive technique yielding a new type of information about the physiology of breast lesions. Absorption is due to haemoglobin and its products, therefore reflecting the angiogenic status of breast tumours.
authors.affiliation: Institut Gustav Roussy, France.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Athanasiou
authors.forename: Daniel
authors.initials: D
authors.lastname: Vanel
authors.forename: Laure
authors.initials: L
authors.lastname: Fournier
authors.forename: Corinne
authors.initials: C
authors.lastname: Balleyguier
mesh_terms: D000042:Absorption; D000328:Adult; D000368:Aged; D001941:Breast Diseases / Q000000981:diagnostic imaging; D001943:Breast Neoplasms / Q000098:blood supply / Q000175:diagnosis* / Q000473:pathology; D002114:Calcinosis / Q000175:diagnosis / Q000473:pathology; D018270:Carcinoma, Ductal, Breast / Q000098:blood supply / Q000175:diagnosis* / Q000473:pathology; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000098:blood supply / Q000175:diagnosis* / Q000473:pathology; D003937:Diagnosis, Differential; D004867:Equipment Design; D005188:False Negative Reactions; D005260:Female; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D008875:Middle Aged; D009389:Neovascularization, Pathologic / Q000175:diagnosis / Q000473:pathology; D010173:Palpation; D011446:Prospective Studies; D011859:Radiography; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D019265:Spectroscopy, Near-Infrared / Q000295:instrumentation / Q000379:methods*; D014172:Transillumination / Q000295:instrumentation / Q000379:methods*
chemical_list: D006454:Hemoglobins; C100003:deoxyhemoglobin