Two new depsipeptides from the marine fungus Spicellum roseum.
Investigation of the secondary metabolites of the marine-derived fungus Spicellum roseum yielded two new cyclohexadepsipeptides, spicellamide A (1) and spicellamide B (2). The structures of 1 and 2 were determined based on extensive evaluations of NMR and MS data. The absolute configuration was deduced after hydrolysis using Marfey's method, chiral chromatography, as well as NOESY and modeling data.
Kralj
Ana
A
Institute for Pharmaceutical Biology, University of Bonn, Bonn, Germany.
Kehraus
Stefan
S
Krick
Anja
A
van Echten-Deckert
Gerhild
G
König
Gabriele M
GM
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor / Q000187:drug effects; D047630:Depsipeptides / Q000737:chemistry / Q000494:pharmacology*; D005658:Fungi; D006801:Humans; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D015394:Molecular Structure; D009447:Neuroblastoma / Q000473:pathology; D008517:Phytotherapy; D051381:Rats
D000972:Antineoplastic Agents, Phytogenic; D047630:Depsipeptides