title: [Association between vascular endothelial growth factor gene 936 T/C polymorphism and colorectal cancer together with anastomotic leakage].
abstract: OBJECTIVE
  To investigate the association between VEGF gene 936 T/C polymorphism and colorectal cancer together with anastomotic leakage.
  
  
  METHODS
  Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to detect the VEGF 936 T/C genotypes in colorectal cancer patients and healthy controls.
  
  
  RESULTS
  There was no significant difference in the frequency of VEGF 936 C/C genotype or C allele between colorectal cancer patients and healthy controls (P > 0.05). The C/C genotype or C allele in colorectal cancer patients with anastomotic leakage was less frequently found than in the group without anastomotic leakage (P < 0.05).
  
  
  CONCLUSIONS
  VEGF 936 C/C genotype or C allele is not related to the development of colorectal cancer, but they can reduce the risk of anastomotic leakage after surgery in colorectal cancer patients.
authors.affiliation: Department of General Surgery, Zhongshan Hospital, Xiamen University, Amoy, China.
authors.forename: Guo-Yang
authors.initials: GY
authors.lastname: Wu
authors.forename: Xiao-Min
authors.initials: XM
authors.lastname: Wang
authors.forename: Michael
authors.initials: M
authors.lastname: Keese
authors.forename: Till
authors.initials: T
authors.lastname: Hasenberg
authors.forename: Jörg W
authors.initials: JW
authors.lastname: Sturm
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D015179:Colorectal Neoplasms / Q000235:genetics* / Q000601:surgery; D016154:Digestive System Fistula / Q000209:etiology / Q000235:genetics*; D016228:Endothelial Growth Factors / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D011183:Postoperative Complications / Q000209:etiology; D054047:Surgical Stomas / Q000009:adverse effects
chemical_list: D016228:Endothelial Growth Factors