Roles of glial p75NTR in axonal regeneration.
The neurotrophin receptor p75 (p75NTR) is expressed by both neurons and glia. Nerve injury triggers up-regulation of p75NTR in Schwann cells (SC) but not in central glia. In contrast to neuronal p75NTR, which mediates negative signals from myelin-associated proteins resulting in neurite collapse, glial p75NTR may play a positive role in nerve regeneration by forming neurotrophin chemoattractant gradients or by competitively antagonizing the NOGO/NgR/LINGO-1 signal through cell-cell contact or regulated intramembranous proteolysis (RIP) of p75NTR. This piece presents some recent evidence supporting this hypothesis.
Zhou
Xin-Fu
XF
Department of Human Physiology and Centre for Neuroscience, Flinders University, Adelaide, South Australia, Australia. xin-fu.zhou@flinders.edu.au
Li
Hong-Yun
HY
D000818:Animals; D001369:Axons / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D009414:Nerve Growth Factors / Q000502:physiology; D009416:Nerve Regeneration; D009457:Neuroglia / Q000378:metabolism / Q000502:physiology*; D020800:Receptor, Nerve Growth Factor / Q000096:biosynthesis / Q000502:physiology*; D012583:Schwann Cells / Q000378:metabolism
D009414:Nerve Growth Factors; D020800:Receptor, Nerve Growth Factor