title: [Nocardiosis as a differential diagnosis of a PET-positive pulmonary nodule].
abstract: We describe the case of a 76-year-old immunocompetent man suspected to have lung cancer in the right upper lobe on the basis of radiographic and clinical findings. The tumour could not be confirmed histologically by transbronchial biopsy. In the fluorodeoxyglucose positron emission tomography (FDG-PET) we found a significantly elevated standard uptake value (SUV) of 13.4. The patient underwent thoracotomy with excision of the tumour, the histological diagnosis was chronic pneumonia. Tissue culture revealed Nocardia spp. Using 16-rDNA-gene sequence analysis the species was identified as Nocardia abscessus. The patient was treated with trimethoprim-sulfamethoxazol regarding the susceptibility profile and improved remarkably both clinically and radiographically.
authors.affiliation: Thoraxzentrum Ruhrgebiet am Evangelischen Krankenhaus Herne-Betriebsstelle Eickel, Klinik für Pneumologie und Infektiologie, Herne. k.darwiche@evk-herne.de
authors.forename: K
authors.initials: K
authors.lastname: Darwiche
authors.forename: B
authors.initials: B
authors.lastname: Totzeck
authors.forename: S
authors.initials: S
authors.lastname: Gatermann
authors.forename: M
authors.initials: M
authors.lastname: Bollow
authors.forename: S
authors.initials: S
authors.lastname: Ewig
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D003937:Diagnosis, Differential; D004359:Drug Therapy, Combination; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging*; D008297:Male; D009617:Nocardia Infections / Q000000981:diagnostic imaging*; D049268:Positron-Emission Tomography; D011859:Radiography; D011868:Radioisotopes; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D011868:Radioisotopes; D019788:Fluorodeoxyglucose F18