title: In vitro and in vivo assessement of the antimalarial activity of sergeolide.
abstract: The antimalarial activity of sergeolide (a quassinoid from PICROLEMMA PSEUDOCOFFEA) was investigated both, IN VITRO on PLASMODIUM FALCIPARUM cultures and IN VIVO through a classical test of schizontocidal action against PLASMODIUM BERGHEI in mice. Sergeolide showed a very strong antiplasmodial activity IN VITRO as well as IN VIVO. Low concentrations (0.006 microg/ml) were able to fully inhibit the IN VITRO growth of chloroquine-sensitive and resistant strains of P. FALCIPARUM. Small amounts (0.26 mg/kg/day) markedly reduced the virulence of experimentally induced P. BERGHEI infection in mice. However, sergeolide, because of its high toxicity (LD 50: 1.8 mg/kg), does not seem, in its present form to be useful for malaria curative treatment.
authors.affiliation: Laboratoire d'immunologie parasitaire, Institut Pasteur de la Guyane Française, 97306, Cayenne Cedex, Guyane Française.
authors.forename: T
authors.initials: T
authors.lastname: Fandeur
authors.forename: C
authors.initials: C
authors.lastname: Moretti
authors.forename: J
authors.initials: J
authors.lastname: Polonsky