title: Members of a novel gene family, Gsdm, are expressed exclusively in the epithelium of the skin and gastrointestinal tract in a highly tissue-specific manner.
abstract: Gasdermin (Gsdm) was originally identified as a candidate causative gene for several mouse skin mutants. Several Gsdm-related genes sharing a protein domain with DFNA5, the causative gene of human nonsyndromic hearing loss, have been found in the mouse and human genomes, and this group is referred to as the DFNA5-Gasdermin domain family. However, our current comparative genomic analysis identified several novel motifs distinct from the previously reported domain in the Gsdm-related genes. We also identified three new Gsdm genes clustered on mouse chromosome 15. We named these genes collectively the Gsdm family. Extensive expression analysis revealed exclusive expression of Gsdm family genes in the epithelium of the skin and gastrointestinal tract in a highly tissue-specific manner. Further database searching revealed the presence of other related genes with a similar N-terminal motif. These results suggest that the Gsdm family and related genes have evolved divergent epithelial expression profiles.
authors.affiliation: Mammalian Genetics Laboratory, Genetic Strains Research Center, National Institute of Genetics, 1111 Yata, Mishima, Shizuoka 411-0845, Japan.
authors.forename: Masaru
authors.initials: M
authors.lastname: Tamura
authors.forename: Shigekazu
authors.initials: S
authors.lastname: Tanaka
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Fujii
authors.forename: Aya
authors.initials: A
authors.lastname: Aoki
authors.forename: Hiromitu
authors.initials: H
authors.lastname: Komiyama
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Ezawa
authors.forename: Kenta
authors.initials: K
authors.lastname: Sumiyama
authors.forename: Tomoko
authors.initials: T
authors.lastname: Sagai
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Shiroishi
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D004848:Epithelium / Q000378:metabolism*; D041981:Gastrointestinal Tract / Q000166:cytology*; D015870:Gene Expression; D006801:Humans; D051379:Mice; D008810:Mice, Inbred C57BL; D008969:Molecular Sequence Data; D009363:Neoplasm Proteins / Q000737:chemistry* / Q000145:classification / Q000235:genetics / Q000502:physiology; D009419:Nerve Tissue Proteins / Q000737:chemistry; D009928:Organ Specificity; D010802:Phylogeny; D011960:Receptors, Estrogen / Q000737:chemistry; D017386:Sequence Homology, Amino Acid; D012867:Skin / Q000166:cytology*; D000094524:Gasdermins
chemical_list: D009363:Neoplasm Proteins; D009419:Nerve Tissue Proteins; D011960:Receptors, Estrogen; C485887:GSDMA protein, human; D000094524:Gasdermins; C111432:GSDME protein, human; C413482:Gsdma protein, mouse; C519847:PJVK protein, human