Carprofen and buprenorphine prevent hyperalgesia in a model of inflammatory pain in cats.
A model of nociceptive threshold determination was developed for evaluation of NSAID analgesia in cats. In a crossover study, eight cats received carprofen (4 mg/kg), buprenorphine (0.01 mg/kg) or saline (0.3 ml) subcutaneously before intradermal kaolin injection on the antebrachium to induce mild inflammation. Pressure thresholds were measured at the injected site using blunt-ended pins advanced by manual inflation of a bladder within a bracelet. Bladder pressure was recorded as threshold (PT) at the behavioural end point. Baseline PT were recorded before kaolin injection (time 0). PT was measured at 2-10 h intervals for 52 h. PT below the lower 95% confidence interval (CI) of baseline values indicated hyperalgesia. After saline, hyperalgesia was detected from 2-6 h, 22-26 h, and at 30 and 36 h. After carprofen, PT remained within the 95% CI. After buprenorphine, PT remained within the 95% CI except at 2h. Carprofen and to some extent buprenorphine, prevented inflammatory hyperalgesia.
Taylor
P M
PM
Taylor Monroe, Gravel Head Farm, Downham Common, Little Downham, Ely, Cambs CB6 2TY, UK. polly@taylormonroe.co.uk
Steagall
P V M
PV
Dixon
M J
MJ
Ferreira
T H
TH
Luna
S P L
SP
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D002047:Buprenorphine / Q000627:therapeutic use*; D002227:Carbazoles / Q000627:therapeutic use*; D002371:Cat Diseases / Q000188:drug therapy*; D002415:Cats; D018592:Cross-Over Studies; D005260:Female; D006930:Hyperalgesia / Q000188:drug therapy / Q000662:veterinary*; D007249:Inflammation / Q000150:complications*; D008297:Male; D010146:Pain / Q000150:complications / Q000188:drug therapy / Q000662:veterinary*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D002227:Carbazoles; D002047:Buprenorphine; C007005:carprofen