Encephalopathy, stroke, and myocardial infarction with DMSO use in stem cell transplantation.
Stem cell transplants are established therapy for hematologic and solid tumor malignancies. Known neurological complications of stem cell transplantation include CNS infection, seizures, strokes, metabolic encephalopathy, and hemorrhage. We report two cases of autologous stem cell transplantation complicated by cerebral infarction and myocardial injury. We postulate that the cryopreservative dimethyl sulfoxide may be responsible.
Chen-Plotkin
Alice S
AS
Department of Neurology, Massachusetts General Hospital and Brigham and Women's Hospital, Boston, MA 02115, USA. aschen@partners.org
Vossel
Keith A
KA
Samuels
Martin A
MA
Chen
Ming Hui
MH
D001930:Brain Injuries / Q000139:chemically induced / Q000175:diagnosis / Q000209:etiology*; D004121:Dimethyl Sulfoxide / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000139:chemically induced / Q000175:diagnosis / Q000209:etiology*; D033581:Stem Cell Transplantation / Q000009:adverse effects*; D020521:Stroke / Q000139:chemically induced / Q000175:diagnosis / Q000209:etiology*
D004121:Dimethyl Sulfoxide