title: Epidemiology of brain death and donation rate in the state of Rio Grande do Sul, Brazil: analysis between 1988 and 2004.
abstract: OBJECTIVE
  To evaluate changes in the profile of potential dead donors brain as to age, gender, and cause of death between 1988 to 2004, as well as the notification rates of potential donors, the donation itself, and family non-authorization.
  
  
  METHODS
  Records of 2,757 potential donors were reviewed in three periods: I: 1988-1992 (n = 465), II: 1993-1997 (n = 567), and III: 1998-2004 (n = 1,725).
  
  
  RESULTS
  The mean age which was similar in periods I and II (30.8 and 29.8 years), increased in period III (38.3 + 18.5 years); (P < .05). The frequency of male donors decreased from 71% and 69%, to 57% (P < .05). The cranium-encephalic trauma decreased from 63.2% and 54.7% to 34.8% (P < .05), while the brain-vascular accidents (CVA) increased from 28.0% and 34.5% to 49.4% (P < .05). The rate of potential donors notified increased from 10.7 per million population per year (pmp/y) and 11.9 to 24.6 pmp/y, while the donation rate increased from 4.4 pmp/y (42.4%) and 7.7 pmp/y (64.3%) to 9.6 pmp/y (38.8%), in periods I, II and III, respectively. The family's nonauthorization changed from 41.5% and 21.7% to 31.9%.
  
  
  CONCLUSIONS
  We observed a similar trend as that in developed countries, that is, a significant increases in the ages of potential donors, in the proportion of female donors, and in the CVA brain death. There has been a significant increase in the notification rate and the donation itself, without a significant modification in family nonauthorization rate.
authors.affiliation: Central de Transplantes do Estado do Rio Grande do Sul, Brazil.
authors.forename: F B
authors.initials: FB
authors.lastname: Capaverde
authors.forename: G G
authors.initials: GG
authors.lastname: Londero
authors.forename: F M
authors.initials: FM
authors.lastname: Figueiredo
authors.forename: N
authors.initials: N
authors.lastname: Hoelfmann
authors.forename: D M S
authors.initials: DM
authors.lastname: Oliveira
authors.forename: V D
authors.initials: VD
authors.lastname: Garcia
mesh_terms: D000328:Adult; D001926:Brain Death; D001938:Brazil; D002423:Cause of Death; D005190:Family; D005260:Female; D006801:Humans; D008297:Male; D012189:Retrospective Studies; D014019:Tissue Donors / Q000706:statistics & numerical data*