Down-regulation of CD72 and increased surface IgG on B cells in patients with lupus nephritis.
The significance of both the acceleratory and inhibitory functions of the CD72 molecule was investigated among patients with systemic lupus erythematosus (SLE) during modification of B cell differentiation. Expression of the CD72 molecule and mRNA on B cells was decreased in SLE with lupus nephritis, while CD100 expression on both CD4+ T cells and CD8+ T cells was not significant in comparison with the controls. When the relationship between CD72 expression and other B cell markers was examined, decreased expression of CD72 was associated with differences in the stage of differentiation. In patients with decreased expression of CD72, switching to IgG was evident, and the disease stage was started to severe. In patients with lupus nephritis, the decreased expression of CD72 was related to class switching on B cells, suggesting that CD72 is a useful marker for determining class switching of B cells in lupus nephritis.
Nakano
Souichiro
S
Department of Rheumatology and Internal Medicine, Juntendo University School of Medicine, Tokyo, Japan.
Morimoto
Shinji
S
Suzuki
Jun
J
Mitsuo
Akiko
A
Nakiri
Yutaka
Y
Katagiri
Akira
A
Nozawa
Kazuhisa
K
Amano
Hirofumi
H
Tokano
Yoshiaki
Y
Hashimoto
Hiroshi
H
Takasaki
Yoshinari
Y
D051997:ADP-ribosyl Cyclase 1 / Q000096:biosynthesis / Q000276:immunology; D000293:Adolescent; D000328:Adult; D000368:Aged; D015703:Antigens, CD / Q000096:biosynthesis* / Q000276:immunology; D000944:Antigens, Differentiation, B-Lymphocyte / Q000096:biosynthesis* / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology*; D051940:B7-2 Antigen / Q000096:biosynthesis / Q000276:immunology; D002454:Cell Differentiation / Q000276:immunology; D015536:Down-Regulation; D005260:Female; D006801:Humans; D017578:Immunoglobulin Class Switching / Q000276:immunology; D007074:Immunoglobulin G / Q000096:biosynthesis / Q000276:immunology*; D008181:Lupus Nephritis / Q000097:blood / Q000276:immunology*; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D008562:Membrane Glycoproteins / Q000096:biosynthesis / Q000276:immunology; D008875:Middle Aged; D011947:Receptors, Antigen, B-Cell / Q000276:immunology; D039961:Semaphorins / Q000096:biosynthesis / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology; D018127:Tumor Necrosis Factor Receptor Superfamily, Member 7 / Q000096:biosynthesis / Q000276:immunology
D015703:Antigens, CD; D000944:Antigens, Differentiation, B-Lymphocyte; D051940:B7-2 Antigen; C093224:CD100 antigen; C064228:CD72 protein, human; C497964:CD86 protein, human; D007074:Immunoglobulin G; D008562:Membrane Glycoproteins; D011947:Receptors, Antigen, B-Cell; D039961:Semaphorins; D018127:Tumor Necrosis Factor Receptor Superfamily, Member 7; C498154:CD38 protein, human; D051997:ADP-ribosyl Cyclase 1