[Experimental study of chronic kidney failure delayed by Xinshen capsule].
OBJECTIVE
To evaluate the effect of Xinshen capsule upon the chronic kidney disease progress by the study of 7/8 kidney removal rat model.


METHODS
The urea nitrogen and the blood creatinine level were estimated by automatic biochemistry analyzer. Hemorheological index level was measured by rheometer. Urine protein was measured by Coomassie brilliant blue. PAS and PASM staining was applied to observe kidney histology change, and semi-quantitative analysis was used to observe the kidney histology change.


RESULTS
In model control group, the urine protein excretory rate and the urea nitrogen, the blood creatinine level were up-regulated obviously, erythrocyte aggregation index and whole blood viscosity value were down-regulated significantly, kidney organizations show up pathological change evidently, and leave surgical group compared the difference. After the treatment of Xinshen capsule, the above indicators are improving obviously.


CONCLUSIONS
Xinshen capsule can degrade urine protein, the urea nitrogen and the blood creatinine level, and lower red blood cell accumulation and the whole blood viscosity, alleviate kidney various pathological change, the medicine can effectively delay the progress of chronic kidney disease.
Yu
Lu
L
The Peoples Liberation Army 305 Hospital, Beijing 100017, China.
Wu
Fan
F
D000818:Animals; D001806:Blood Urea Nitrogen; D001809:Blood Viscosity / Q000187:drug effects; D002214:Capsules; D003404:Creatinine / Q000097:blood; D004903:Erythrocyte Aggregation / Q000187:drug effects; D005260:Female; D007668:Kidney / Q000187:drug effects* / Q000473:pathology; D007676:Kidney Failure, Chronic / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D008516:Medicine, Chinese Traditional; D011507:Proteinuria / Q000652:urine; D051381:Rats; D017207:Rats, Sprague-Dawley
D002214:Capsules; D003404:Creatinine