title: Calcium-dependent transcription of cytokine genes in T lymphocytes.
abstract: The increase in intracellular calcium ion concentration is a general signaling mechanism used in many biological systems. In T lymphocytes, calcium is essential for activation, differentiation, and effector functions. In this study, we will summarize recent developments of how intracellular calcium concentrations are modified in T cells to affect the activity of three major calcium-dependent transcriptional effectors, i.e., NFAT, MEF2, and DREAM, involved in cytokine gene expression.
authors.affiliation: Centro Nacional de Biotecnología, Consejo Superior de Investigaciones Cientificas, Madrid, Spain.
authors.forename: Magali
authors.initials: M
authors.lastname: Savignac
authors.forename: Britt
authors.initials: B
authors.lastname: Mellström
authors.forename: Jose R
authors.initials: JR
authors.lastname: Naranjo
mesh_terms: D000818:Animals; D002118:Calcium / Q000502:physiology*; D015220:Calcium Channels / Q000502:physiology; D016207:Cytokines / Q000378:metabolism*; D006801:Humans; D013601:T-Lymphocytes / Q000378:metabolism*; D014157:Transcription Factors / Q000502:physiology; D014158:Transcription, Genetic / Q000502:physiology
chemical_list: D015220:Calcium Channels; D016207:Cytokines; D014157:Transcription Factors; D002118:Calcium