Prenylated Phenolics that Cause Contact Dermatitis from Glandular Trichomes of Turricula parryi.
The principal phenolic constituents were isolated from the exudate of the glandular trichomes of TURRICULA PARRYI, a California shrub that causes severe contact dermatitis. The phenolic constituents consist of a complex mixture of methoxylated flavones and derivatives of both farnesylhydroquinone and 3-farnesyl- P-hydroxybenzoic acid in which the C-7 methyl of farnesyl is replaced by hydroxymethyl, formyl and carboxyl groups. Elicitors of allergic contact dermatitis were identified with guinea pigs sensitized to the crude exudate. The principal agents of dermatitis were the farnesyihydroquinone derivatives 3 and 6.
Reynolds
G W
GW
Phytochemistry Laboratory, Departments of Developmental and Cell Biology, and Ecology and Evolutionary Biology, University of California, Irvine, Irvine, California 92717.
Proksch
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Rodriguez
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