Urinary F2-isoprostanes are poor prognostic indicators for the development of bronchopulmonary dysplasia.
OBJECTIVE
Oxygen toxicity is thought to contribute to the development of bronchopulmonary dysplasia (BPD). Oxidant injury leads to formation of F(2)-isoprostanes (F(2)-IsoP). We hypothesized that urinary excretion of the stable metabolite of F(2)-IsoP, 8-iso-PGF(2alpha), would be higher in infants who develop BPD than those who did not.


METHODS
Forty infants <30-weeks gestational age (GA) were enrolled, 24 infants with BPD and 16 without BPD. Urine specimens were collected weekly and stored at -80 degrees C until analyzed. Urinary 8-iso-PGF(2alpha) was measured by gas chromatography/mass spectrometry (GC-MS) and normalized to creatinine excretion.


RESULTS
GA and birth weight (BW) were lower in infants who developed BPD than those who did not. Urinary 8-iso-PGF(2alpha) levels in the first or third weeks of age were not significantly different between the two groups.


CONCLUSIONS
Urinary excretion of 8-iso-PGF(2alpha) in early postnatal life in preterm infants is not correlated with the development of BPD.
Reuter
S D
SD
Department of Pediatrics, Section of Neonatology, Baylor College of Medicine, Houston, TX, USA. reuters@siouxvalley.org
O'Donovan
D J
DJ
Hegemier
S E
SE
Smith
E O
EO
Heird
W C
WC
Fernandes
C J
CJ
D015415:Biomarkers / Q000097:blood / Q000652:urine*; D001724:Birth Weight; D001997:Bronchopulmonary Dysplasia / Q000175:diagnosis* / Q000652:urine; D015237:Dinoprost / Q000031:analogs & derivatives / Q000097:blood; D028441:F2-Isoprostanes / Q000652:urine*; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D007231:Infant, Newborn; D019102:Infant, Very Low Birth Weight; D008297:Male; D011237:Predictive Value of Tests; D011379:Prognosis; D012307:Risk Factors
D015415:Biomarkers; D028441:F2-Isoprostanes; C075750:8-epi-prostaglandin F2alpha; D015237:Dinoprost