title: Impact of off-pump coronary artery bypass surgery on graft patency: current best available evidence.
abstract: For more than three decades cardiac surgeons have been used to perform delicate coronary anastomoses on cardiopulmonary bypass (CPB). However, the price of a still and bloodless field is ultimately paid by the patients in the form of sequelae of negative effects of CPB including blood trauma, activation of a series of inflammatory responses, nonpulsatile flow, and possible embolization of air or debris. In an attempt to avoid these deleterious effects of CPB, off-pump coronary artery bypass surgery (OPCAB) has been rediscovered and refined. Although abundant evidence is available to suggest that excellent results can be achieved when CPB is avoided, concerns have been raised about quality of anastomosis and graft patency rates after OPCAB surgery. We are currently practicing in an era of evidence-based medicine that mandates the prospective randomized controlled trial (RCT) as the most accurate tool for determining a treatment benefit compared with a control population. This review article attempts to evaluate the current best available evidence from RCTs on the impact of OPCAB surgery on graft patency.
authors.affiliation: Department of Cardiac Surgery, Royal Hospital for Sick Children, Glasgow, UK. drrajashahzad@hotmail.com
authors.forename: Shahzad G
authors.initials: SG
authors.lastname: Raja
authors.forename: Gilles D
authors.initials: GD
authors.lastname: Dreyfus
mesh_terms: D002908:Chronic Disease; D047549:Coronary Artery Bypass, Off-Pump; D023921:Coronary Stenosis / Q000503:physiopathology / Q000601:surgery; D019317:Evidence-Based Medicine; D006801:Humans; D016032:Randomized Controlled Trials as Topic; D015203:Reproducibility of Results; D012501:Saphenous Vein / Q000503:physiopathology / Q000601:surgery; D016896:Treatment Outcome; D014654:Vascular Patency