title: Regioselective palladium-catalyzed formate reduction of N-heterocyclic allylic acetates.
abstract: The regioselective palladium-catalyzed formate reduction of allylic acetates in five- to eight-membered heterocycles is reported. Reduction of allylic acetates under mild conditions using allylpalladium chloride dimer, phosphines, and formic acid/triethylamine in DMF gives the exo-cyclic olefins in good regioselectivities and high yields. Synthetic application in preparing N-tosyl-3-oxo-piperidine is also reported.
authors.affiliation: Department of Chemistry, National Central University, Jhongli City, Taoyuan, Taiwan 32001.
authors.forename: Hsiu-Yi
authors.initials: HY
authors.lastname: Cheng
authors.forename: Chong-Si
authors.initials: CS
authors.lastname: Sun
authors.forename: Duen-Ren
authors.initials: DR
authors.lastname: Hou