Optimization of dual-band continuum light source for ultrahigh-resolution optical coherence tomography.
We demonstrate a dual-band continuum light source centered at 830 and 1300 nm for optical coherence tomography (OCT) generated by pumping a photonic crystal fiber having two closely spaced zero-dispersion wavelengths with a femtosecond laser at 1059 nm. By use of polarization control, sidelobe suppression can be improved up to approximately 7.7 dB. By employing compression of the pump pulses, the generated spectrum is smooth and near-Gaussian, resulting in a point-spread function with negligible sidelobes. We demonstrate ultrahigh-resolution OCT imaging of biological tissue in vivo and in vitro using this light source and compare it with conventional-resolution OCT imaging at 1300 nm.
Wang
Hui
H
Department of Biomedical Engineering, Case Western Reserve University, Ohio 44106, USA. hxw26@case.edu
Rollins
Andrew M
AM
D004867:Equipment Design; D019544:Equipment Failure Analysis; D005336:Fiber Optic Technology / Q000295:instrumentation*; D007089:Image Enhancement / Q000295:instrumentation* / Q000379:methods*; D007834:Lasers; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D041623:Tomography, Optical Coherence / Q000295:instrumentation* / Q000379:methods*