title: Motor development in school-aged children with 22q11 deletion (velocardiofacial/DiGeorge syndrome).
abstract: The aim of this study was to compare the motor development of primary school children (age 5-14y) with a 22q11 deletion (del22q11) group and a control group. The effects of a congenital heart defect (CHD) and IQ on motor development were additionally studied within the del22q11 group. Motor development of 37 children with a del22q11 (20 males, 17 females; mean age 9y 4mo, range 5y 9mo-13y 3mo) and 34 controls (23 males, 11 females; mean age 9y 1mo, range 4y 8mo-13y 6mo) was assessed with the Bruininks-Oseretsky Test of Motor Proficiency. The del22q11 group showed a significant deficit in motor functioning compared with the control group (p < 0.01). Within the del22q11 group there was a significant effect of IQ on motor performance, but no effect of CHD was found. To conclude, primary school children with a del22q11 syndrome showed a significant deficit in motor performance compared with a control group. A significant effect of IQ on motor performance in del22q11 was found.
authors.affiliation: Faculty of Kinesiology and Rehabilitation Sciences, Katholieke Universiteit Leuven, Leuven, Belgium. katrijn.vanaken@faber.kuleuven.be
authors.forename: Katrijn
authors.initials: K
authors.lastname: Van Aken
authors.forename: Bert
authors.initials: B
authors.lastname: De Smedt
authors.forename: Annelies
authors.initials: A
authors.lastname: Van Roie
authors.forename: Marc
authors.initials: M
authors.lastname: Gewillig
authors.forename: Koen
authors.initials: K
authors.lastname: Devriendt
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Fryns
authors.forename: Johan
authors.initials: J
authors.lastname: Simons
authors.forename: Ann
authors.initials: A
authors.lastname: Swillen
mesh_terms: D000293:Adolescent; D000704:Analysis of Variance; D016022:Case-Control Studies; D002648:Child; D002657:Child Development / Q000502:physiology*; D002892:Chromosomes, Human, Pair 22; D003072:Cognition Disorders / Q000175:diagnosis / Q000209:etiology / Q000235:genetics; D004062:DiGeorge Syndrome / Q000150:complications* / Q000235:genetics; D005260:Female; D017353:Gene Deletion; D006330:Heart Defects, Congenital / Q000150:complications / Q000235:genetics; D006801:Humans; D007360:Intelligence / Q000235:genetics; D008297:Male; D009048:Motor Skills / Q000502:physiology*; D019957:Motor Skills Disorders / Q000175:diagnosis / Q000209:etiology* / Q000235:genetics