Chemokines and squamous cancer of the head and neck: targets for therapeutic intervention?
The biological properties of squamous carcinoma cells are intimately regulated by a multitude of cytokines and growth factors; the most well studied of these include epidermal growth factor receptor agonists and members of the transforming growth factor-beta family. The recent explosion of research in the field of chemokine function as a mediator of tumor progression has led to the possibility that these small, immunomodulatory proteins also play key roles in squamous carcinogenesis and may, therefore, be potential targets for novel therapeutic approaches.
Yeudall
W Andrew
WA
Virginia Commonwealth University School of Dentistry, Philips Institute for Oral & Craniofacial Molecular Biology, Department of Biochemistry and Massey Cancer Center, Richmond, VA 23298, USA. wayeudall@vcu.edu
Miyazaki
Hiroshi
H
D020816:Amino Acid Motifs; D000595:Amino Acid Sequence; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000098:blood supply / Q000188:drug therapy* / Q000503:physiopathology; D002470:Cell Survival; D002471:Cell Transformation, Neoplastic; D018925:Chemokines / Q000037:antagonists & inhibitors / Q000502:physiology*; D019743:Chemokines, CXC / Q000037:antagonists & inhibitors / Q000502:physiology; D018450:Disease Progression; D015195:Drug Design; D066246:ErbB Receptors / Q000037:antagonists & inhibitors / Q000502:physiology; D006258:Head and Neck Neoplasms / Q000098:blood supply / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D008969:Molecular Sequence Data; D009361:Neoplasm Invasiveness; D009363:Neoplasm Proteins / Q000037:antagonists & inhibitors / Q000502:physiology*; D009389:Neovascularization, Pathologic / Q000188:drug therapy / Q000503:physiopathology; D019707:Receptors, Chemokine / Q000187:drug effects / Q000502:physiology; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D015398:Signal Transduction; D016212:Transforming Growth Factor beta / Q000037:antagonists & inhibitors / Q000502:physiology
D000970:Antineoplastic Agents; D018925:Chemokines; D019743:Chemokines, CXC; D009363:Neoplasm Proteins; D019707:Receptors, Chemokine; D016212:Transforming Growth Factor beta; D066246:ErbB Receptors