Anne of Austria (1601-1666), queen of France: died of breast cancer.
Anne of Austria ("the Spain's infant"), was married to Louis XIII, on October 25th, 1615. She became queen of France and they had two children: Louis (the future Louis XIV) and Philippe, duke of Orleans. Everybody knows that Anne of Austria died of breast cancer. This is a widely known fact, so we are not going to add anything but some details, which are generally ignored.
Androutsos
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Institute of History of Medicine, University Claude Bernard, Lyon, France.