[Notes on cases of carcinoma of the uterine body observed in the S. Anna Hospital, Turin, between 1954-1969 and the Piedmont and Aosta Valley areas in the period 1965-1969].
An increase in the frequency of corpus cancer over the period 1954-1969 and 1965-1969 in records for the S. Anna Hospital, Turin, and the Piedmont and Aosta Valley areas respectively is reported. Attention is drawn to the fact that more than 30% of patients were in the 66-80 age group (i.e. over the usual age of 56 to 60). A higher frequency of infertility and delayed menopause in patients with such tumours has been proved statistically significant. Diabetes, obesity and hypertension are pathogenetically linked to adenocarcinoma of the endometrium and not to casual associations. The findings are in line with the view that this neoplasia is hormone-dependent and a public health programme for its prevention is proposed.
Leone
G
G
Obstetrics and Gynaecology Division, S. Anna Hospital, Turin.
Lanza
A
A
D000230:Adenocarcinoma / Q000453:epidemiology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001284:Atrophy; D002277:Carcinoma / Q000453:epidemiology* / Q000517:prevention & control; D002278:Carcinoma in Situ / Q000453:epidemiology; D015897:Comorbidity; D003920:Diabetes Mellitus / Q000453:epidemiology; D016889:Endometrial Neoplasms / Q000453:epidemiology; D004715:Endometriosis / Q000453:epidemiology; D004717:Endometrium / Q000473:pathology; D004967:Estrogens; D005260:Female; D012739:Gonadal Steroid Hormones / Q000378:metabolism; D006801:Humans; D006965:Hyperplasia; D006973:Hypertension / Q000453:epidemiology; D007247:Infertility, Female / Q000453:epidemiology; D007558:Italy / Q000453:epidemiology; D007889:Leiomyoma / Q000453:epidemiology; D008593:Menopause; D008875:Middle Aged; D009376:Neoplasms, Hormone-Dependent / Q000453:epidemiology; D009378:Neoplasms, Multiple Primary / Q000453:epidemiology; D009765:Obesity / Q000453:epidemiology; D011230:Precancerous Conditions / Q000453:epidemiology; D011446:Prospective Studies; D017584:Reproductive History; D012189:Retrospective Studies; D012307:Risk Factors; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology; D014594:Uterine Neoplasms / Q000453:epidemiology* / Q000517:prevention & control
D004967:Estrogens; D012739:Gonadal Steroid Hormones