[Expression of core binding factor a1, bone morphogenetic proteins and osteopontin in the developing periodontal tissues of mice].
OBJECTIVE
To study the expression and interaction of core binding factor a1 (Cbfa1), bone morphogenetic proteins (BMPs) and osteopontin (OPN) in the developing periodontal tissues of mice.


METHODS
A mice developing periodontal tissues study model was created histologically by 5-27 day postnatal BALB/c mice, then the immunohistochemical localization of Cbfa1, BMPs and OPN in different developing stages were undertaken.


RESULTS
In early stage of postnatal mice periodontal tissues development, only BMPs expressed in dental follicle cells, though the signal was weak. When root was forming, all of them were expressed in periodontal ligament cells and cementoblasts, while only OPN in acellular cementum, cellular cementum and the surface of alveolar bone, Cbfa1 only in cellular cementum and BMPs was seen in neither acellular cementum nor cellular cementum.


CONCLUSIONS
Cbfa1, BMPs and OPN all involve in the development of periodontal tissues, while OPN is crucial for cementum.
Yang
Pi-Shan
PS
Dept. of Periodontology, School of Stomatology, Shandong University, Jinan 250012, China.
Pan
Ke-Qing
KQ
Li
Shu
S
Jiang
Bo
B
D000818:Animals; D019485:Bone Morphogenetic Proteins; D001842:Bone and Bones; D050660:Core Binding Factors; D003739:Dental Cementum; D051379:Mice; D008807:Mice, Inbred BALB C; D053495:Osteopontin; D010513:Periodontal Ligament; D014092:Tooth Root
D019485:Bone Morphogenetic Proteins; D050660:Core Binding Factors; D053495:Osteopontin