NGF mRNA is expressed in the dorsal root ganglia after spinal cord injury in the rat.
Nerve growth factor (NGF) mRNA is expressed in a variety of cell types in the injured spinal cord and its protein implicated in both positive and negative neurological outcomes of cord injury. Here we demonstrate that NGF mRNA is also upregulated in dorsal root ganglion (DRG) neurons after spinal cord injury and that the percentage of sensory neurons expressing NGF mRNA correlates with proximity to the lesion epicenter. Our data suggest that, in DRG, NGF gene expression may be upregulated by damage to the central processes of sensory neurons.
Brown
Arthur
A
Spinal Cord Injury Team, BioTherapeutics Research Group, Robarts Research Institute, 100 Perth Drive, PO Box 5015, London, Ontario, Canada. abrown@robarts.ca <abrown@robarts.ca>
Ricci
Mary-Jo
MJ
Weaver
Lynne C
LC
D000818:Animals; D005727:Ganglia, Spinal / Q000378:metabolism* / Q000473:pathology; D017403:In Situ Hybridization; D020932:Nerve Growth Factor / Q000235:genetics*; D009475:Neurons, Afferent / Q000378:metabolism / Q000473:pathology; D012333:RNA, Messenger / Q000378:metabolism*; D051381:Rats; D013119:Spinal Cord Injuries / Q000378:metabolism* / Q000473:pathology; D015854:Up-Regulation
D012333:RNA, Messenger; D020932:Nerve Growth Factor