Antihypertensive Treatment of Acute Cerebral Hemorrhage (ATACH): rationale and design.
This trial is a multicenter open-labeled pilot trial to determine the tolerability and safety of three escalating levels of antihypertensive treatment goals for acute hypertension in 60 subjects with supratentorial intracerebral hemorrhage (ICH). The pilot trial is the natural development of numerous case series evaluating the effect of antihypertensive treatment of acute hypertension in subjects with ICH. The proposed trial will have important public health implications by providing necessary information for a definitive phase III study regarding the efficacy of antihypertensive treatment of acute hypertension in subjects with ICH. The specific aims of the present pilot study are to: (1) Determine the tolerability of the treatment as assessed by achieving and maintaining three different systolic blood pressure goals with intravenous nicardipine infusion for 18 to 24 hours postictus in subjects with ICH who present within 6 hours of symptom onset; (2) Define the safety, assessed by the rate of neurological deterioration during treatment and serious adverse events, of three escalating systolic blood pressure treatment goals using intravenous nicardipine infusion; and (3) Obtain preliminary estimates of the treatment effect using the rate of hematoma expansion (within 24 hours) and modified Rankin scale and Barthel index at 3 months following symptom onset.
Qureshi
Adnan I
AI
Clinical Research Division, Zeenat Qureshi Stroke Research Center, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ 07103, USA. aiqureshi@hotmail.com
D000208:Acute Disease; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D002543:Cerebral Hemorrhage / Q000188:drug therapy*; D002908:Chronic Disease; D003937:Diagnosis, Differential; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000209:etiology*; D010865:Pilot Projects; D011446:Prospective Studies; D015203:Reproducibility of Results; D012449:Safety
D000959:Antihypertensive Agents