Improving outcomes for limited stage small cell lung cancer patients in Scotland with concomitant chemoradiation.
OBJECTIVE
To determine whether the introduction of early concomitant chemoradiotherapy for patients with limited stage small cell lung cancer (LS-SCLC) has resulted in acceptable outcomes and toxicity in a UK practice.


METHODS
The case records of all patients with LS-SCLC treated with chemoradiotherapy from July 2001 to 2004 were reviewed, and subjected to descriptive statistics and proportional hazards analysis.


RESULTS
Concomitant chemoradiotherapy was delivered to 30 patients and sequential chemoradiotherapy was delivered to 36 patients. The former patients tended to be younger (mean 58.9 vs 64.1 years, P=0.01); the latter patients tended to have bulkier disease. There was no difference in performance status, but cisplatin was given more often in the former group (90% vs 44%, P<0.0001). Grade 3 acute oesophagitis occurred in less than 10% of either group and there were no cases of grade 3 or greater pneumonitis. Two-year actuarial survival for the concomitant group was 53% (95% confidence interval 36-71%) and 36% (95% confidence interval 20-52%) for the sequential group (P=0.018). Proportional hazards analysis showed an increased hazard of death with increasing performance status and age, sequential therapy and the use of cisplatin with sequential therapy.


CONCLUSIONS
Concomitant chemoradiotherapy can be safely given in a UK population with outcomes comparable with those reported in North American series.
Law
A B
AB
Edinburgh Cancer Centre and University of Edinburgh, Western General Hospital, Edinburgh, UK. alastair.law@luht.scot.nhs.uk
Erridge
S C
SC
MacKean
M J
MJ
Kerr
G R
GR
Ironside
J A D
JA
Little
F A
FA
Price
A
A
D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D018288:Carcinoma, Small Cell / Q000188:drug therapy / Q000532:radiotherapy; D002945:Cisplatin / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008175:Lung Neoplasms / Q000188:drug therapy / Q000532:radiotherapy; D008297:Male; D008875:Middle Aged; D011832:Radiation Injuries; D018714:Radiotherapy, Adjuvant; D012189:Retrospective Studies; D012606:Scotland
D000970:Antineoplastic Agents; D002945:Cisplatin