Nevirapine-induced fulminant hepatitis.
Nevirapine induced hepatotoxicity is known but fatality is rare. We report a case of a young individual who developed nevirapine (NVP) induced fatal hepatitis without apparent risk factors or preceding rash. Exacerbation of underlying silent chronic liver dysfunction possibly contributed to the fatal outcome. This case stresses the need for careful evaluation, regular monitoring and prompt omission of drug on suspicion of hepatotoxicity.
Maniar
J K
JK
Department of Infectious Diseases, Jaslok Hospital and Research Centre, Mumbai, India.
Shah
S R
SR
Verma
Reena
R
Kamath
R
R
Gupte
P
P
Maniar
A
A
D000328:Adult; D044966:Anti-Retroviral Agents / Q000009:adverse effects*; D017809:Fatal Outcome; D015658:HIV Infections / Q000188:drug therapy; D006801:Humans; D017114:Liver Failure, Acute / Q000139:chemically induced* / Q000401:mortality; D008297:Male; D019829:Nevirapine / Q000009:adverse effects*; D012307:Risk Factors
D044966:Anti-Retroviral Agents; D019829:Nevirapine