High-speed, high-resolution optical coherence tomography retinal imaging with a frequency-swept laser at 850 nm.
High-speed, high-resolution optical coherence tomography (OCT) imaging of the human retina is demonstrated using a frequency-swept laser at 850 nm. A compact external cavity semiconductor laser design, optimized for swept-source ophthalmic OCT, is described. The laser enables an effective 16 kHz sweep rate with >10 mm coherence length and a tuning range of approximately 35 nm full width at half-maximum, yielding an axial resolution of <7 micro m in tissue.
Srinivasan
V J
VJ
Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. vjsriniv@mit.edu
Huber
R
R
Gorczynska
I
I
Fujimoto
J G
JG
Jiang
J Y
JY
Reisen
P
P
Cable
A E
AE
D004867:Equipment Design; D019544:Equipment Failure Analysis; D006801:Humans; D007089:Image Enhancement / Q000295:instrumentation* / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000295:instrumentation* / Q000379:methods; D007834:Lasers; D015203:Reproducibility of Results; D012160:Retina / Q000166:cytology*; D042261:Retinoscopes; D012680:Sensitivity and Specificity; D041623:Tomography, Optical Coherence / Q000295:instrumentation* / Q000379:methods