title: Varicocele-induced testicular dysfunction may be associated with disruption of blood-testis barrier.
abstract: The objective of this study was to examine E-cadherin and alpha-catenin expression at the junctions between adjacent Sertoli cells in testicular specimens from patients with varicocele in order to determine the presence of a possible link between blood-testis barrier and pathophysiology of varicocele. A total of 51 testicular biopsies were obtained from 28 infertile men with unilateral or bilateral varicocele. Twenty-three patients had bilateral and 5 had unilateral varicocele, Grade I varicocele was detected in 30 (59%), grade II in 15 (29%) and grade III in 6 (12%) patients. Abnormal expression of E-cadherin and alpha-catenin at the junctions between adjacent Sertoli cells was demonstrated in 100% and 90% of the patients with varicocele, respectively. In those with grade I-III varicocele, the mean E-cadherin and alpha-catenin expression were 7.6 +/- 11.4 and 39 +/- 36; 7.6 +/- 0.0 and 49 +/- 30; 8.3 +/- 9.3 and 58 +/- 33, respectively, but the difference was not significant. Reduced E-cadherin and alpha-catenin expression at the junctions between adjacent Sertoli cells may be associated with disruption of blood-testis barrier in varicocele.
authors.affiliation: Department of Urology, Akdeniz University, Antalya, Turkey. tkoksal@akdeniz.edu.tr
authors.forename: I T
authors.initials: IT
authors.lastname: Koksal
authors.forename: Y
authors.initials: Y
authors.lastname: Ishak
authors.forename: M
authors.initials: M
authors.lastname: Usta
authors.forename: A
authors.initials: A
authors.lastname: Danisman
authors.forename: E
authors.initials: E
authors.lastname: Guntekin
authors.forename: I C
authors.initials: IC
authors.lastname: Bassorgun
authors.forename: A
authors.initials: A
authors.lastname: Ciftcioglu
mesh_terms: D000328:Adult; D001706:Biopsy; D001814:Blood-Testis Barrier / Q000502:physiology*; D015820:Cadherins / Q000378:metabolism; D006801:Humans; D007248:Infertility, Male / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012661:Semen / Q000737:chemistry; D012708:Sertoli Cells / Q000473:pathology; D013733:Testicular Diseases / Q000209:etiology / Q000473:pathology*; D014646:Varicocele / Q000473:pathology*; D051178:alpha Catenin / Q000378:metabolism
chemical_list: D015820:Cadherins; D051178:alpha Catenin