title: Stability of succinylcholine solutions stored at room temperature studied by nuclear magnetic resonance spectroscopy.
abstract: The effect of storage temperature on the stability of two succinylcholine chloride solutions (20 and 50 mg/ml) was evaluated. Molecular composition was analysed using nuclear magnetic resonance spectroscopy. At room temperature, the degradation rate constant was 1.2%/month for the 20 mg/ml solution and 2.1%/month for the 50 mg/ml solution. The corresponding monthly degradation rates for the two solutions were 0.18% and 0.30% when stored at 4 degrees C, and 5.4% and 8.1% when stored at 37 degrees C. If a 10% loss of potency is considered acceptable, then the 20 and 50 mg/ml succinylcholine solutions can be stored in emergency resuscitation carts at room temperature for 8.3 and 4.8 months, respectively.
authors.affiliation: SAMU 93-EA 3409, Hôpital Avicenne, 125, Rue de Stalingrad, 93009 Bobigny Cedex, France. frederic.adnet@avc.aphp.fr
authors.forename: Frederic
authors.initials: F
authors.lastname: Adnet
authors.forename: Laurence
authors.initials: L
authors.lastname: Le Moyec
authors.forename: Charles E
authors.initials: CE
authors.lastname: Smith
authors.forename: Michel
authors.initials: M
authors.lastname: Galinski
authors.forename: Patricia
authors.initials: P
authors.lastname: Jabre
authors.forename: Frederic
authors.initials: F
authors.lastname: Lapostolle
mesh_terms: D004355:Drug Stability; D004356:Drug Storage / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy; D009467:Neuromuscular Depolarizing Agents / Q000737:chemistry*; D013390:Succinylcholine / Q000737:chemistry*; D013696:Temperature
chemical_list: D009467:Neuromuscular Depolarizing Agents; D013390:Succinylcholine