Offering to share: how to put heads together in autism neuroimaging.
Data sharing in autism neuroimaging presents scientific, technical, and social obstacles. We outline the desiderata for a data-sharing scheme that combines imaging with other measures of phenotype and with genetics, defines requirements for comparability of derived data and recommendations for raw data, outlines a core protocol including multispectral structural and diffusion-tensor imaging and optional extensions, provides for the collection of prospective, confound-free normative data, and extends sharing and collaborative development not only to data but to the analytical tools and methods applied to these data. A theme in these requirements is the need to preserve creative approaches and risk-taking within individual laboratories at the same time as common standards are provided for these laboratories to build on.
Belmonte
Matthew K
MK
Department of Human Development, Cornell University, Martha Van Rensselaer Hall, Ithaca, NY 14853-4401, USA. belmonte@mit.edu
Mazziotta
John C
JC
Minshew
Nancy J
NJ
Evans
Alan C
AC
Courchesne
Eric
E
Dager
Stephen R
SR
Bookheimer
Susan Y
SY
Aylward
Elizabeth H
EH
Amaral
David G
DG
Cantor
Rita M
RM
Chugani
Diane C
DC
Dale
Anders M
AM
Davatzikos
Christos
C
Gerig
Guido
G
Herbert
Martha R
MR
Lainhart
Janet E
JE
Murphy
Declan G
DG
Piven
Joseph
J
Reiss
Allan L
AL
Schultz
Robert T
RT
Zeffiro
Thomas A
TA
Levi-Pearl
Susan
S
Lajonchere
Clara
C
Colamarino
Sophia A
SA
D001321:Autistic Disorder / Q000175:diagnosis* / Q000453:epidemiology; D001921:Brain / Q000002:abnormalities* / Q000000981:diagnostic imaging*; D002648:Child; D003072:Cognition Disorders / Q000175:diagnosis / Q000453:epidemiology; D003299:Cooperative Behavior; D005260:Female; D006801:Humans; D007400:Interprofessional Relations; D008279:Magnetic Resonance Imaging; D008297:Male; D009483:Neuropsychological Tests; D010641:Phenotype; D049268:Positron-Emission Tomography; D012938:Social Perception