[Effects of heterogenous suberect spatholobus stem on peripheral blood cell counts of 60Co gamma ray irradiated mice].
OBJECTIVE
To investigate the effects of heterogenous suberect spatholobus stem (Spatholobus suberectu, Mucuna birdwoodiana, Millettia oosperma and Millettia dielsiana) on peripheral blood cell counts of mice with bone marrow suppression induced by (60)Co gamma ray irradiation.


METHODS
Bone marrow suppression was induced by sublethal dose of (60)Co gamma ray in mice. White blood cell (WBC), red blood cell (RBC) and platelet (PLT) counts in peripheral blood of the mice were detected one day, 3, 7, 14 and 21 days after intragastric administration of different doses of the four kinds of suberect spatholobus stem, respectively.


RESULTS
A slowdown of the decrease of WBC, RBC and PLT counts in peripheral blood of the mice with bone marrow suppression was observed after intragastric administration. The WBC, RBC and PLT counts in the Mucuna birdwoodiana-treated and Spatholobus suberectu-treated groups were significantly higher than those in the untreated group (P<0.05).


CONCLUSIONS
All the four kinds of heterogenous suberect spatholobus stem can accelerate the recovery of WBC, RBC and PLT counts in peripheral blood of mice with bone marrow suppression, while the effects of Spatholobus suberectu and Mucuna birdwoodiana are relatively good.
Wang
Hong
H
Research Institute for Clinical Pharmacology, General Hospital of People's Liberation Army of China, Beijing 100853, China.
Liu
Ping
P
Dai
Chang
C
Wang
Dong-xiao
DX
D000818:Animals; D001772:Blood Cell Count; D003037:Cobalt Radioisotopes / Q000009:adverse effects; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D007887:Fabaceae / Q000737:chemistry*; D005260:Female; D005720:Gamma Rays / Q000009:adverse effects*; D008297:Male; D051379:Mice; D033641:Millettia / Q000737:chemistry; D031299:Mucuna / Q000737:chemistry; D008517:Phytotherapy; D018547:Plant Stems / Q000737:chemistry*; D011832:Radiation Injuries / Q000097:blood / Q000209:etiology / Q000517:prevention & control*; D011897:Random Allocation; D014916:Whole-Body Irradiation
D003037:Cobalt Radioisotopes; D004365:Drugs, Chinese Herbal