title: Anti-influenza A virus activities of mannan-binding lectins and bovine conglutinin.
abstract: Mannan-binding lectin (MBL) and bovine conglutinin (BKg) belong to the collectin family, which is involved in first-line host defense against various infectious agents. We have previously reported that human MBL inhibited type A influenza viral hemagglutination, infection and spreading to adjacent cells without complement activation. In this study, we investigated the direct antiviral activities of bovine MBL, rabbit MBL and BKg. All collectins used in this study inhibited viral infectivity and hemagglutination at concentrations of 0.02-0.3 microg/ml. They also demonstrated inhibitory activity against viral spreading. Like human MBL, bovine MBL and BKg showed antiviral activities at their physiological concentrations. These results suggest that mammalian MBLs and BKg may inhibit the spread of influenza A virus through the bloodstream.
authors.affiliation: Department of Infectious Diseases, Osaka Prefectural Institute of Public Health, Japan.
authors.forename: Takao
authors.initials: T
authors.lastname: Kawai
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Kase
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Souji
authors.initials: S
authors.lastname: Eda
authors.forename: Takashi
authors.initials: T
authors.lastname: Sakamoto
authors.forename: Katsuki
authors.initials: K
authors.lastname: Ohtani
authors.forename: Nobutaka
authors.initials: N
authors.lastname: Wakamiya
mesh_terms: D000818:Animals; D002417:Cattle; D002460:Cell Line; D037222:Collectins / Q000494:pharmacology*; D004285:Dogs; D006385:Hemagglutination Inhibition Tests; D006801:Humans; D053122:Influenza A Virus, H3N2 Subtype / Q000254:growth & development*; D007251:Influenza, Human / Q000188:drug therapy* / Q000378:metabolism / Q000821:virology; D037601:Mannose-Binding Lectin / Q000494:pharmacology*; D011817:Rabbits; D012712:Serum Globulins / Q000494:pharmacology*
chemical_list: D037222:Collectins; D037601:Mannose-Binding Lectin; D012712:Serum Globulins; C024014:conglutinin