Methyl spongoate, a cytotoxic steroid from the Sanya soft coral Spongodes sp.
A new steroid with an uncommon 21-oic acid methyl ester moiety designated methyl spongoate (1) which exhibited potent cytotoxicity against BEL-7402 tumor cells in vitro has been isolated from the Sanya soft coral Spongodes sp. Its structure was determined by detailed interpretation of spectroscopic data and by comparison with related compounds.
Yan
Xiao-Hong
XH
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, PR China.
Lin
Li-Ping
LP
Ding
Jian
J
Guo
Yue-Wei
YW
D000818:Animals; D037421:Anthozoa; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D015195:Drug Design; D004354:Drug Screening Assays, Antitumor; D004952:Esters / Q000737:chemistry; D006801:Humans; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D008956:Models, Chemical; D008968:Molecular Conformation; D013053:Spectrophotometry; D013256:Steroids / Q000737:chemistry* / Q000494:pharmacology*
D000970:Antineoplastic Agents; D004952:Esters; D013256:Steroids; C520999:methyl spongoate