The role of cytokines in the regulation of ocular autoimmune inflammation.
The eye is a unique place for the development of an immune response. Beyond the usual mechanisms of immune restraint, the eye evolved with its exclusive mechanisms such as anterior chamber associated immune deviation. Therefore, immune-mediated inflammation in the eye does not develop at the same pace as in other sites of the body. Here we will address such peculiarities as they regard to ocular autoimmunity, using the experimental autoimmune uveitis as a model to understand the participation of cytokines in the process of aggression against the eye, as well as their immunoregulatory role.
Vallochi
Adriana L
AL
Fundação Universidade Federal do Rio Grande, Rio Grande, Rio Grande do Sul, Brazil.
Commodaro
Alessandra G
AG
Schwartzman
Jean P
JP
Belfort
Rubens
R
Rizzo
Luiz V
LV
D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology* / Q000473:pathology; D015551:Autoimmunity; D016207:Cytokines / Q000276:immunology*; D006801:Humans; D009928:Organ Specificity / Q000276:immunology; D014605:Uveitis / Q000276:immunology* / Q000473:pathology
D016207:Cytokines